Effects of thalamic stimulation on tremor, balance, and step initiation: a single subject study.
This study was conducted to evaluate the clinically apparent balance improvements in a patient with Parkinson's disease who had stimulating electrodes surgically implanted to the VIM nucleus of the right thalamus for control of left-upper-extremity tremor. Experiments were conducted to determine if balance improved simply because the large-amplitude upper-extremity tremor was reduced or if the neural control of balance improved. Using EMGs and forceplate recordings, we quantified the effects of the thalamic stimulation on the contralateral upper-extremity tremor and on the lower-extremity postural muscle activations for quiet stance, step initiation, and equilibrium responses to surface displacements. The results demonstrated that, beside reducing the amplitude and destabilizing effects of the upper-extremity tremor, the thalamic stimulation was also effective in reducing tremor activity of the trunk and contralateral lower-extremity muscles. In addition, the contralateral lower-extremity muscle activation patterns, strengths, and durations for the balance tasks were enhanced during stimulation. These results suggest that thalamic stimulation improved this patient's balance by reducing tremor in the contralateral extremities and by increasing burst duration and magnitude of the tibialis anterior, which functions as the postural prime mover for the step initiation and balance tasks.
Burleigh
A L
AL
Department of Physiology, Oregon Health Sciences University, Portland.
Horak
F B
FB
Burchiel
K J
KJ
Nutt
J G
JG
D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D004576:Electromyography; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D004856:Postural Balance; D013786:Thalamic Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D013787:Thalamic Nuclei / Q000503:physiopathology*; D013979:Tibial Nerve / Q000502:physiology*; D014202:Tremor / Q000209:etiology / Q000503:physiopathology*; D014743:Videotape Recording