title: Intracranial plasma cell granuloma presenting as an optic neuropathy.
abstract: A 40-year-old man presented with a left optic neuropathy. Magnetic resonance imaging demonstrated a contrast-enhancing mass along the course of the left trigeminal nerve and in the region of the left cavernous sinus with suprasellar extension. Preoperatively, he had a serum polyclonal gammopathy. Pathologic diagnosis was an intracranial plasma cell granuloma. The patient responded to high-dose steroids with resolution of his optic neuropathy, marked decrease in the size of the mass, and resolution of the serum polyclonal gammopathy. Intracranial plasma cell granuloma is a rare lesion; only 11 cases have been described in the literature. Almost half of the patients presented with vision loss as their chief complaint.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
authors.forename: S R
authors.initials: SR
authors.lastname: Kodsi
authors.forename: B R
authors.initials: BR
authors.lastname: Younge
authors.forename: J A
authors.initials: JA
authors.lastname: Leavitt
authors.forename: R J
authors.initials: RJ
authors.lastname: Campbell
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D003937:Diagnosis, Differential; D006104:Granuloma, Plasma Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014276:Trigeminal Nerve / Q000473:pathology
chemical_list: D011241:Prednisone