Hypomelanosis of Ito and precocious puberty.
We describe two girls with hypomelanosis of Ito, one of whom was demonstrated to have diploid-triploid mixoploidy in skin fibroblasts. Both had precocious puberty which was probably gonadotrophin-independent. The association of precocious puberty and hypomelanosis of Ito has not been previously reported. We have speculated on the possible mechanism of gonadotrophin-independent precocious puberty.
Daubeney
P E
PE
Hospitals for Sick Children, London, United Kingdom.
Pal
K
K
Stanhope
R
R
D002648:Child; D002675:Child, Preschool; D005260:Female; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006801:Humans; D010859:Pigmentation Disorders / Q000150:complications* / Q000378:metabolism; D011003:Ploidies; D011629:Puberty, Precocious / Q000150:complications* / Q000235:genetics
D006065:Gonadotropins, Pituitary