title: Cytokines and peripheral tolerance to alloantigen.
abstract: The induction of peripheral tolerance to alloantigen is accompanied in many cases by a decrease in the production of cytokines such as IL-2 and IFN gamma, yet a sustained production of cytokines such as IL-10 and IL-4. Whether or not this altered pattern of cytokine production in tolerant animals is causally related to the induction and/or maintenance of the tolerant state has yet to be fully determined, although experiments blocking selectively the action of IL-2 with CD25 antibodies suggest that manipulation of cytokine production may at least be a route to tolerance. Alternative methods for directly influencing the cytokine balance are sought and recent experiments on the CD28/CTLA-4-B7 interaction suggest a possible approach.
authors.affiliation: University of Oxford, Nuffield Department of Surgery, John Radcliffe Hospital, Headington, England.
authors.forename: M J
authors.initials: MJ
authors.lastname: Dallman
authors.forename: K J
authors.initials: KJ
authors.lastname: Wood
authors.forename: K
authors.initials: K
authors.lastname: Hamano
authors.forename: A R
authors.initials: AR
authors.lastname: Bushell
authors.forename: P J
authors.initials: PJ
authors.lastname: Morris
authors.forename: M J
authors.initials: MJ
authors.lastname: Wood
authors.forename: H M
authors.initials: HM
authors.lastname: Charlton
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007519:Isoantigens / Q000276:immunology*; D014181:Transplantation Immunology
chemical_list: D016207:Cytokines; D007519:Isoantigens