Cardiac preconditioning. Induction of endogenous tolerance to ischemia-reperfusion injury.
Cardiac preconditioning is a phenomenon by which a brief exposure to ischemia renders the heart more tolerant of a subsequent sustained ischemic insult. Understanding the mechanism involved may allow pharmacologic access to this protective state before cardiopulmonary bypass surgery and transplantation. We discuss herein the preconditioning phenomenon, the potential mechanisms involved, and the therapeutic implications of cardiac preconditioning.
Meldrum
D R
DR
Department of Surgery, University of Colorado Health Sciences Center, Denver.
Mitchell
M B
MB
Banerjee
A
A
Harken
A H
AH
D000241:Adenosine / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D017202:Myocardial Ischemia / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism* / Q000517:prevention & control; D017682:Myocardial Stunning / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D010656:Phenylephrine / Q000494:pharmacology / Q000627:therapeutic use; D011493:Protein Kinase C / Q000502:physiology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D018047:Receptors, Purinergic P1 / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
D011942:Receptors, Adrenergic, alpha; D018047:Receptors, Purinergic P1; D010656:Phenylephrine; D011493:Protein Kinase C; D000241:Adenosine