Isometric exercise increases strength and does not produce sustained creatinine phosphokinase increases in a patient with polymyositis.
A patient with active stable idiopathic polymyositis received a 4-week supervised right quadriceps and biceps isometric strengthening program. He demonstrated a significant increase in isometric peak torque without a sustained rise in creatinine phosphokinase (CPK). A significant decrease in postexercise CPK occurred at the end of the exercise program. We conclude a randomized clinical trial using a nonexercised patient group vs an exercised patient group may be useful.
Hicks
J E
JE
Department of Rehabilitation Medicine, National Institutes of Health, Bethesda, MD 20892.
Miller
F
F
Plotz
P
P
Chen
T H
TH
Gerber
L
L
D003402:Creatine Kinase / Q000097:blood*; D005081:Exercise Therapy; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology*; D017285:Polymyositis / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*
D003402:Creatine Kinase