Antioestrogen inhibits myelination in brains of juvenile Zebra finches.
The effects of the antioestrogen Keoxifene on the ontogenetic process of myelination, on the differentiation of neurones of telencephalic song motor centres, on cerebellar structures and on behaviour were studied in male Zebra finches. Brain differentiation was studied by using computer aided analysis of silver impregnated brain sections and by measuring soma sizes of neurones after Nissl staining. An antioestrogen induced inhibition of myelination could be detected in the song motor centre robust nucleus of the archistriatum (RA) and in the cerebellum, whereas the region magnocellular nucleus of the anterior neostriatum (MAN) showed no difference between treated birds and controls.
Güttinger
H R
HR
Abteilung für Allgemeine Zoologie, Universität Kaiserslautern, Homburg/Saar, Germany.
Herth
G
G
Stocker
S
S
Kafitz
K W
KW
Kallenbach
M
M
D000818:Animals; D001717:Birds / Q000254:growth & development*; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D008297:Male; D009186:Myelin Sheath / Q000187:drug effects* / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology; D020849:Raloxifene Hydrochloride
D004965:Estrogen Antagonists; D010880:Piperidines; D020849:Raloxifene Hydrochloride