title: Localization of 15 cosmids on human chromosome 22 by fluorescence in situ hybridization.
abstract: Fluorescence in situ hybridization has been used in a cytogenetic analysis to map 15 cosmids on human chromosome 22. Thirteen cosmids were localized on the long arm of chromosome 22 (22q) while two other probes displayed a hybridization signal on 22p and the short arm of the acrocentric chromosomes of groups D and G. The regional assignment of these new chromosome markers will improve the mapping of chromosome 22; they can be used to detect numerical and structural aberrations of this chromosome involved in numerous pathologies.
authors.affiliation: CNRS URA 1158, Laboratoire de Cytogénétique et Génétique Oncologiques, Institut Gustave-Roussy, Villejuif, France.
authors.forename: N
authors.initials: N
authors.lastname: Lévy
authors.forename: V
authors.initials: V
authors.lastname: Lamour
authors.forename: G
authors.initials: G
authors.lastname: Danglot
authors.forename: R
authors.initials: R
authors.lastname: Slim
authors.forename: M
authors.initials: M
authors.lastname: Lipinski
authors.forename: A
authors.initials: A
authors.lastname: Bernheim
mesh_terms: D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D003360:Cosmids / Q000235:genetics*; D015342:DNA Probes / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence
chemical_list: D015342:DNA Probes; D005819:Genetic Markers