Anxiety sensitivity and response to cholecystokinin tetrapeptide in healthy volunteers.
The authors determined whether fear of anxiety symptoms mediates panicogenic responses to cholecystokinin tetrapeptide (CCK-4) in healthy subjects. Individuals with a preexisting high level of anxiety sensitivity (N = 10) experienced significantly more catastrophic cognitions and fear of somatic symptoms than did subjects with low (N = 9) or medium (N = 17) anxiety sensitivity, but they were not more susceptible to experiencing a panic attack. Thus, cognitive factors do not appear to be critical determinants of CCK-4-induced panic attacks.
Koszycki
D
D
Department of Psychiatry, St. Mary's Hospital Center, Montreal, Que., Canada.
Cox
B J
BJ
Bradwejn
J
J
D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000139:chemically induced*; D001794:Blood Pressure / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D005239:Fear / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000139:chemically induced*; D010555:Personality Inventory; D013758:Tetragastrin / Q000494:pharmacology*
D013758:Tetragastrin