[The effect of indapamide on phosphate metabolism in hypertensive patients].
Twenty-four patients were studied to assess the efficacy and principle of indapamide in hypertensive patients previously treated and unsatisfactorily controlled with either angiotensin-converting enzyme (ACE) inhibitor or atenolol therapy. The result showed a satisfactory anti-hypertensive effect of indapamide. Plasma phosphate concentrations were markedly reduced and no significant variance in plasma K+, Na+ and Ca+ concentration after two weeks of indapamide therapy (2.5 mg, one day). Thus indapamideinduced reduction of blood pressure could be mediated by an effect of this drug on phosphate balance.
Fang
P
P
Changzheng Hospital, Second Military Medical University, PLA, Shanghai.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates; D007190:Indapamide