title: [Activation mechanisms of lipid peroxidation in rat's tissue in various types of hypoxia].
abstract: The mechanisms of lipid peroxidation (LP) intensification in the rat myocardium, brain and liver were studied under hypoxic hypoxia and hemic hypoxia. The level of intensification depends on the type of hypoxia and is characterized by tissue specificity. It is shown that LP is activated by hypoxia. This activation is more pronounced under hemic hypoxia associated with more marked catecholamine accumulation, deficiency of the antioxidant glutathione system, decrease of the cytochrome c-oxidase activity. The level of lipid peroxides was higher in the rat liver under both types of hypoxia.
authors.forename: I M
authors.initials: IM
authors.lastname: Mankovska
authors.forename: M M
authors.initials: MM
authors.lastname: Seredenko
authors.forename: N M
authors.initials: NM
authors.lastname: Nagnybida
authors.forename: A I
authors.initials: AI
authors.lastname: Nazarenko
authors.forename: L V
authors.initials: LV
authors.lastname: Bratus
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002395:Catecholamines; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D003576:Electron Transport Complex IV
vernacular_title: Osoblyvosti mekhanizmiv intensyfikatsiĭ perekysnogo okyslennia lipidiv u tkanynakh shchuriv pry gipoksiĭ riznogo typu.