title: Features of thrombi and diagnostic accuracy of impedance plethysmography in symptomatic and asymptomatic deep vein thrombosis.
abstract: Impedance plethysmography (IPG) has high sensitivity and specificity in patients with symptomatic deep vein thrombosis (DVT) while it fails to detect asymptomatic DVT. The aim of this study was to determine whether the features of thrombi such as location, size and occlusiveness could explain the different accuracy of IPG in symptomatic and asymptomatic DVT patients. One-hundred and seventeen consecutive outpatients with a clinical suspicion of DVT and 246 consecutive patients undergoing hip surgery were admitted to the study. In symptomatic patients IPG was performed on the day of referral, followed by venography, while in asymptomatic patients IPG was performed as a surveillance programme, followed by bilateral venography. A venography proved DVT was observed in 37% of the symptomatic patients and 34% of the asymptomatic limbs. A significantly higher proportion of proximal DVTs was found in symptomatic patients than in asymptomatic patients (78% vs 46%; p = 0.001). The mean Marder score, taken as an index of thrombus size, was significantly higher in symptomatic patients than in asymptomatic patients (19.0 vs 9.6; p = 0.0001). A significantly higher proportion of occlusive DVTs was observed in symptomatic than in asymptomatic patients (69% vs 36%; p = 0.001). We conclude that the unsatisfactory diagnostic accuracy of IPG in asymptomatic DVT is due to the high prevalence of distal, small and non occlusive thrombi. Such thrombi are unlikely to cause a critical obstruction of the venous outflow and therefore to produce a positive IPG.
authors.affiliation: Istituto di Medicina Interna e di Medicina Vascolare, Università di Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Agnelli
authors.forename: B
authors.initials: B
authors.lastname: Cosmi
authors.forename: S
authors.initials: S
authors.lastname: Radicchia
authors.forename: F
authors.initials: F
authors.lastname: Veschi
authors.forename: E
authors.initials: E
authors.lastname: Boschetti
authors.forename: L
authors.initials: L
authors.lastname: Lupattelli
authors.forename: E
authors.initials: E
authors.lastname: Rinonapoli
authors.forename: G G
authors.initials: GG
authors.lastname: Nenci
mesh_terms: D003871:Dermatan Sulfate / Q000627:therapeutic use; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005188:False Negative Reactions; D005260:Female; D006620:Hip Fractures / Q000097:blood / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D010992:Plethysmography, Impedance; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000517:prevention & control
chemical_list: D003871:Dermatan Sulfate