title: Serological evaluation of a simplified immunization schedule using quadruple DPT-polio vaccine in Burkina Faso.
abstract: The immunogenicity of quadruple DPT-polio vaccine used in a two-dose regimen was investigated in a cross-sectional serological survey involving 355 children under 5 years of age. This schedule is currently applied in the EPI programme in three provinces in Burkina Faso, West Africa. It was found that two doses of quadruple DPT-polio vaccine induced antibodies at protective levels to diphtheria and tetanus toxin, and to the three types of polioviruses in over 90% of 179 children. The persistence of antibodies to tetanus and polioviruses is good, since over 90% of the children studied still had antibodies more than 2 years after their last vaccination. The antibodies to diphtheria toxin tend to decline in the first 6 months after vaccination, which is not uncommon. However, our data indicate clearly that a very high percentage (98%) of children have been primed to diphtheria toxin. Of 176 non-vaccinated children, up to 25% of the older ones had antibodies to polioviruses, most of them only to one type. This appears to be a sensitive parameter for the circulation of wild polioviruses in the environment. As the vaccination coverage in the study area was low (< 60%), it was to be expected that the circulation of polioviruses in the community could not be interrupted. The present study demonstrates the applicability of a two-dose strategy for primary immunization with a quadruple DPT-polio vaccine especially for poliovirus components and the toxoids. To induce pertussis immunity, however, a third vaccination is recommended.
authors.affiliation: RIVM: National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: Rümke
authors.forename: M
authors.initials: M
authors.lastname: Schlumberger
authors.forename: B
authors.initials: B
authors.lastname: Floury
authors.forename: J
authors.initials: J
authors.lastname: Nagel
authors.forename: B
authors.initials: B
authors.lastname: van Steenis
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D002050:Burkina Faso / Q000453:epidemiology; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004167:Diphtheria Toxin / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008457:Measles / Q000453:epidemiology; D011051:Poliomyelitis / Q000453:epidemiology; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000276:immunology; D013742:Tetanus / Q000453:epidemiology / Q000276:immunology; D014611:Vaccination; D014917:Whooping Cough / Q000453:epidemiology
chemical_list: D000907:Antibodies, Bacterial; D004167:Diphtheria Toxin; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated