title: [Oxygen-dependent processes in the liver and immunologic reactivity of rats in chronic liver damage induced by carbon tetrachloride].
abstract: The chronic hepatitis in Wistar rats was induced by seven subcutaneous injections of carbon tetrachloride (0.3 ml of 50% oil solution per 1 kg of body mass) made each third day. It was shown that cytochromes P-450 and b5 content, demethylase activity in the liver microsomal fraction as well as the oxygen tension in the liver tissue were decreased, while lipid peroxidation was intensified. The PHA-induced blood lymphocyte blastogenesis was inhibited and concentration of circulating immune complexes in the blood was higher than that in intact animals.
authors.forename: I N
authors.initials: IN
authors.lastname: Alekseeva
authors.forename: T M
authors.initials: TM
authors.lastname: Bryzgina
authors.forename: S I
authors.initials: SI
authors.lastname: Pavlovich
authors.forename: V I
authors.initials: VI
authors.lastname: Nosar
authors.forename: L I
authors.initials: LI
authors.lastname: Aleksiuk
authors.forename: N V
authors.initials: NV
authors.lastname: Makogon
authors.forename: Ia N
authors.initials: IaN
authors.lastname: Gotsuliak
authors.forename: T V
authors.initials: TV
authors.lastname: Martynova
authors.forename: O V
authors.initials: OV
authors.lastname: Sidorenko
authors.forename: V S
authors.initials: VS
authors.lastname: Sukhina
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D002908:Chronic Disease; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism*; D006388:Hemagglutinins; D007279:Injections, Subcutaneous; D015227:Lipid Peroxidation; D008213:Lymphocyte Activation; D008862:Microsomes, Liver / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006388:Hemagglutinins; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D010088:Oxidoreductases
vernacular_title: Kislorodzavisimye protsessy v pecheni i immunologicheskaia reaktivnost organizma krys pri khronicheskom porazhenii pecheni chetyrkhkhloristymuglerodom.