Virulence of two Streptococcus pyogenes strains (types M1 and M3) associated with toxic-shock-like syndrome depends on an intact mry-like gene.
The major virulence factor of Streptococcus pyogenes, the M protein, is positively regulated at the transcriptional level by mry in the M type 6 strain studied. We show here that in two S. pyogenes strains isolated from cases of toxic-shock-like syndrome, a type M1 strain and a type M3 strain, an mry-like gene is also required for resistance to phagocytosis.
Perez-Casal
J F
JF
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322.
Dillon
H F
HF
Husmann
L K
LK
Graham
B
B
Scott
J R
JR
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002352:Carrier Proteins; D005340:Fibrinogen / Q000378:metabolism; D005798:Genes, Bacterial; D006801:Humans; D016254:Mutagenesis, Insertional; D010587:Phagocytosis; D011485:Protein Binding; D012772:Shock, Septic / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein; D005340:Fibrinogen