title: Hypomelanosis of Ito and precocious puberty.
abstract: We describe two girls with hypomelanosis of Ito, one of whom was demonstrated to have diploid-triploid mixoploidy in skin fibroblasts. Both had precocious puberty which was probably gonadotrophin-independent. The association of precocious puberty and hypomelanosis of Ito has not been previously reported. We have speculated on the possible mechanism of gonadotrophin-independent precocious puberty.
authors.affiliation: Hospitals for Sick Children, London, United Kingdom.
authors.forename: P E
authors.initials: PE
authors.lastname: Daubeney
authors.forename: K
authors.initials: K
authors.lastname: Pal
authors.forename: R
authors.initials: R
authors.lastname: Stanhope
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006801:Humans; D010859:Pigmentation Disorders / Q000150:complications* / Q000378:metabolism; D011003:Ploidies; D011629:Puberty, Precocious / Q000150:complications* / Q000235:genetics
chemical_list: D006065:Gonadotropins, Pituitary