Silicone oil as a delivery vehicle for BCNU in rabbit proliferative vitreoretinopathy.
The antiproliferative properties of a single intravitreous injection of BCNU [carmustine; 1,3-bis(2 chloroethyl)-1-nitrosourea] dissolved in 1 ml of medical grade, 1,000-centistoke silicone oil were evaluated in a rabbit model of proliferative vitreoretinopathy (PVR). 10 micrograms and 15 micrograms of BCNU in 1 ml silicone oil resulted in a 46% and 27% reduction in the incidence of retinal detachments, respectively. Chi-square tests showed a significant statistical difference (P < 0.05) between the control and treated groups. However, histopathologic examination of the eyes injected with BCNU and silicone oil indicated some retinal disorganization even at the lower therapeutic levels. With a therapeutic index of < 1.0, BCNU in silicone oil has a low margin of safety for treatment of PVR. Nevertheless, this study demonstrates that silicone oil when used for retinal tamponade in PVR may be the vehicle for delivery of a lipophilic antiproliferative agent.
Arroyo
M H
MH
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114.
Refojo
M F
MF
Araiz
J J
JJ
Tolentino
F I
FI
Cajita
V N
VN
Elner
V M
VM
D000818:Animals; D002330:Carmustine / Q000008:administration & dosage / Q000627:therapeutic use*; D002478:Cells, Cultured; D003228:Conjunctiva / Q000187:drug effects; D004195:Disease Models, Animal; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005069:Evaluation Studies as Topic; D005128:Eye Diseases / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D007267:Injections; D008297:Male; D011817:Rabbits; D012163:Retinal Detachment / Q000517:prevention & control; D012164:Retinal Diseases / Q000188:drug therapy* / Q000473:pathology; D012827:Silicone Oils; D014822:Vitreous Body / Q000473:pathology
D004337:Drug Carriers; D012827:Silicone Oils; D002330:Carmustine