title: Erythrocyte ALA-d activity in experimentally lead-poisoned ducks and its change during treatment with disodium calcium EDTA.
abstract: To determine useful procedures for the diagnosis and prognosis of lead poisoning in waterfowl caused by ingestion of lead pellets, erythrocyte delta-aminolevulinic acid dehydratase (ALA-d) was investigated in experimentally lead-poisoned ducks. A highly positive correlation was observed between the concentration of blood lead and the ALA-d activity ratio (the ratio of activated:non-activated enzyme activity) in those birds given seven lead pellets (3 mm diameter). The ALA-d activity ratio rapidly increased after the administration of lead pellets, but began to fall immediately after the initiation of disodium calcium ethylenediamine tetra-acetate (CaEDTA) therapy which resulted in a rapid decrease in the concentration of lead in the blood of these birds. In contrast, the ALA-d activity remained inhibited even after blood lead levels began to decrease following treatment. These results demonstrated that the ALA-d activity ratio is a very useful and sensitive indicator for the diagnosis and evaluation of therapeutic effects after lead poisoning in waterfowl.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Murase
authors.forename: N
authors.initials: N
authors.lastname: Horiba
authors.forename: I
authors.initials: I
authors.lastname: Goto
authors.forename: O
authors.initials: O
authors.lastname: Yamato
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Jin
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: Y
authors.initials: Y
authors.lastname: Maede
mesh_terms: D000818:Animals; D004372:Ducks; D004492:Edetic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D004911:Erythrocyte Volume; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D000623:Porphobilinogen Synthase / Q000097:blood*; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D007854:Lead; D004492:Edetic Acid; D000623:Porphobilinogen Synthase