title: A comparative study of cyclosporine and its derivative SDZ IMM-125 in canine renal allografts.
abstract: The immunosuppressive efficacy of CsA and its derivative SDZ IMM-125 was compared in highly mismatched mongrel dogs in receipt of renal allografts. At an equal dose of 15 mg/kg/day and in the same drug vehicle, SDZ IMM-125 was not superior to CsA in prolonging allograft survival. Whole blood levels of SDZ IMM-125 were lower than those achieved for CsA. No specific drug-related side effects were noticed in this model.
authors.affiliation: University Department of Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom.
authors.forename: C J
authors.initials: CJ
authors.lastname: Watson
authors.forename: S M
authors.initials: SM
authors.lastname: Metcalfe
authors.forename: D G
authors.initials: DG
authors.lastname: St John Collier
authors.forename: R Y
authors.initials: RY
authors.lastname: Calne
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000097:blood / Q000627:therapeutic use* / Q000633:toxicity; D003524:Cyclosporins / Q000097:blood / Q000627:therapeutic use* / Q000633:toxicity; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine; C075935:SDZ IMM 125