Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice.
Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T1/2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A/J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 micrograms/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 micrograms/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.
Nesnow
S
S
Carcinogenesis and Metabolism Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
Gold
A
A
Sangaiah
R
R
Slaga
T J
TJ
D000818:Animals; D001564:Benzo(a)pyrene; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D005260:Female; D008748:Methylcholanthrene / Q000031:analogs & derivatives*; D051379:Mice; D009153:Mutagens; D010212:Papilloma / Q000139:chemically induced*; D011721:Pyrenes; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D009153:Mutagens; D011721:Pyrenes; C016328:cyclopenta(c,d)pyrene; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; C037411:benz(j)aceanthrylene