[Protective effect of panaxatriols on function of reproductive endocrine axis in radiation-injured rats].
After whole body irradiation with X-ray 5 Gy (radiation condition: 0.31 Gy.min-1, 200 kV, 10 mA, 0.5 mm Cu and 1.0 mm Al), the male rats were given ip panaxatriols 5 mg.d-1 24 h before and after irradiation for 14 d. The results showed that hypothalamic leu-enkephalin (165 +/- 12 vs 131 +/- 14 pg.mg-1), pituitary beta-endorphin (2.3 +/- 0.5 vs 1.6 +/- 0.3 ng.mg-1) contents, and serum testosterone (1.66 +/- 0.15 vs 0.82 +/- 0.23 ng.ml-1) level were decreased, while serum FSH (1.34 +/- 0.10 vs 1.99 +/- 0.10 ng.ml-1) level increased in irradiation group vs normal control. These indices approached to control levels in irradiation + panaxatriols group. These suggest that panaxatriols have protective effects on reproductive endocrine axis and promote their recovering course from the radiation injuries.
Gong
S L
SL
Department of Radiation Biology, Norman Bethune University of Medical Sciences, Changchun, China.
Li
X M
XM
Lü
Z
Z
Liu
S Z
SZ
D000818:Animals; D004743:Enkephalin, Leucine / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000097:blood; D036145:Ginsenosides; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000627:therapeutic use; D013739:Testosterone / Q000097:blood; D014315:Triterpenes / Q000627:therapeutic use*; D014916:Whole-Body Irradiation; D001615:beta-Endorphin / Q000378:metabolism*
D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes; D013739:Testosterone; D004743:Enkephalin, Leucine; D001615:beta-Endorphin; D005640:Follicle Stimulating Hormone; C004563:panaxatriol