Increase of central 5-HT1B binding sites following 5,7-dihydroxytryptamine axotomy in the adult rat.
The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surgery, an upregulation of 5-HT1B receptors in the entorhinal cortex and the dorsomedial and suprachiasmatic nuclei of the hypothalamus. The cellular localization of those 5-HT1B receptors exhibiting post-lesion plastic properties is discussed.
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Unité de Neuroendocrinologie Expérimentale INSERM, U 297, Marseille, France.
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Héry
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Héry
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Faudon
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François-Bellan
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D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001369:Axons / Q000187:drug effects*; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D003714:Denervation; D007031:Hypothalamus / Q000378:metabolism; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D008032:Limbic System / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D015854:Up-Regulation
D011985:Receptors, Serotonin; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin