title: Phenazoviridin, a novel free radical scavenger from Streptomyces sp. Taxonomy, fermentation, isolation, structure elucidation and biological properties.
abstract: Phenazoviridin is a newly discovered free radical scavenger from microorganisms. It was isolated from the culture of Streptomyces sp. HR04. The structure of phenazoviridin was determined as 6-(3-methyl-2-butenyl)phenazine-1-carboxylic acid 6-deoxy-alpha-L-talopyranose ester on the basis of its spectroscopic and physico-chemical properties. The novel substance showed strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibited antihypoxic activity in mice.
authors.affiliation: Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Shindo
authors.forename: Y
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: M
authors.initials: M
authors.lastname: Matsuoka
authors.forename: H
authors.initials: H
authors.lastname: Kawai
authors.forename: J
authors.initials: J
authors.lastname: Mochizuki
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005285:Fermentation; D016166:Free Radical Scavengers; D006601:Hexoses / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011190:Potassium Cyanide / Q000037:antagonists & inhibitors / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D006601:Hexoses; D010619:Phenazines; C084384:phenazoviridin; D011190:Potassium Cyanide