Clinical, biological and histological considerations on primary intracranial germinomas in the prevalent sites.
Twenty-four germinomas from which tumor sites were 11 pineal, 7 suprasellar, and 6 basal ganglial and thalamic (BG-T) were subjected. Humoral tumor markers of HCG, CEA and AFP were measured and compared with immunohistochemistries for these tumor markers along with PLAP, HPL and PKK1. Humoral tumor markers and immunohistochemistries did not always comprehend to each other. Difference of the survival rates among tumor sites was thought to be attributed to the variabilities in their histological, immunochemical and flow cytometric results.
Numoto
R T
RT
Division of Neuropathology, Jikei University School of Medicine.
Tanaka
J
J
Yasue
M
M
Kamio
M
M
Watabe
K
K
Nakamura
N
N
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D018237:Germinoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm