A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.
de Laszlo
S E
SE
Merck Research Laboratories, Rahway, New Jersey 07065.
Quagliato
C S
CS
Greenlee
W J
WJ
Patchett
A A
AA
Chang
R S
RS
Lotti
V J
VJ
Chen
T B
TB
Scheck
S A
SA
Faust
K A
KA
Kivlighn
S S
SS
D000284:Administration, Oral; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001665:Binding Sites; D011799:Quinazolines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011945:Receptors, Angiotensin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects
D057911:Angiotensin Receptor Antagonists; D011799:Quinazolines; D011945:Receptors, Angiotensin; D000804:Angiotensin II