title: Host-specific hemagglutination of influenza A (H1N1) virus.
abstract: H1N1 strains of influenza A virus isolated during the influenza season of 1991-92 were divided into two groups according to the property of host-specific hemagglutination. Group 1 viruses agglutinated human and chicken red blood cells. Group 2 viruses agglutinated human but not chicken red blood cells. The viruses of both groups, however, showed the same antigenic structure determined with ferret antisera. The virus clones which were plaque-purified twice from a group 2 virus retained the characteristic of host-specific hemagglutination after five successive passages in MDCK cells, indicating that this phenomenon is genetically determined. However, the amino acid sequences of the hemagglutinin (HA) polypeptides deduced from the nucleotide sequences of the HA gene of the two groups did not show any differences between them. This suggests a difference in amino acids in some other polypeptide(s), which affects the host-specific hemagglutination.
authors.affiliation: Department of Virology, Aichi Prefectural Institute of Public Health, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Morishita
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Miyake
authors.forename: Y
authors.initials: Y
authors.lastname: Ishihara
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D002645:Chickens / Q000097:blood; D002648:Child; D004285:Dogs; D004912:Erythrocytes; D006384:Hemagglutination; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000302:isolation & purification / Q000502:physiology*; D007251:Influenza, Human / Q000382:microbiology; D007668:Kidney; D019158:N-Acetylneuraminic Acid; D009439:Neuraminidase / Q000032:analysis; D011991:Receptors, Virus / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012794:Sialic Acids / Q000378:metabolism; D013045:Species Specificity; D015678:Viral Structural Proteins / Q000032:analysis; D014771:Virion / Q000737:chemistry; D014776:Virus Cultivation
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D011991:Receptors, Virus; D012794:Sialic Acids; D015678:Viral Structural Proteins; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid