Salivary neoplasms of the palate: a flow cytometric and clinicopathological analysis.
In order to test the clinical and prognostic significance of flow cytometrically assessed DNA content in minor salivary gland tumours we evaluated 75 neoplasms of the palate, 55 of which were carcinomas. Benign neoplasms were exclusively DNA diploid with low S-phase fractions while 22 per cent of malignant tumours manifested a DNA aneuploidy and 23.5 per cent high S-phase fractions (> 5 per cent). Significant statistical correlations between DNA content and tumour size, histological grade, lymph node metastasis and lethality were observed. Our findings suggest a potentially important role for flow-cytometry in the evaluation of these neoplasms.
Carrillo
R
R
Department of Anatomic Pathology, Hospital Ramon y Cajal, Madrid, Spain.
Batsakis
J G
JG
Weber
R
R
Luna
M A
MA
el-Naggar
A K
AK
D000230:Adenocarcinoma / Q000235:genetics; D008949:Adenoma, Pleomorphic / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm