Rhein and aloe-emodin kinetics from senna laxatives in man.
Therapeutic doses of two laxatives (Agiolax and Sennatin) were repeatedly administered to 10 healthy volunteers in a two-way change-over design. Blood samples were collected up to 96 h after the first dose, and plasma levels of total aloe-emodin and rhein were determined simultaneously with a sensitive (lower limit of quantification: 0.5 ng aloe-emodin and 2.5 ng rhein per millilitre plasma) and specific fluorometric HPLC method. Aloe-emodin was not detectable in any plasma sample of any subject. Rhein concentration time courses showed highest levels of 150-160 ng/ml and peak maxima at 3-5 h and 10-11 h after dosing probably according to absorption of free rhein and rhein released from prodrugs (e.g. sennosides) by bacterial metabolism, respectively.
Krumbiegel
G
G
Department of Pharmacokinetics, Madaus AG, Köln, FRG.
Schulz
H U
HU
D000293:Adolescent; D000328:Adult; D000880:Anthraquinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002366:Cassia; D002400:Cathartics / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage; D010943:Plantago; D010946:Plants, Medicinal; D012676:Senna Extract / Q000008:administration & dosage; D000081226:Sennosides
D000880:Anthraquinones; D002400:Cathartics; D004338:Drug Combinations; D010936:Plant Extracts; D000081226:Sennosides; C024255:ispaghula, senna drug combination; D012676:Senna Extract; C020491:rhein; C004315:danthron