[Studies on pyridazinone derivatives. XV. Oxidative reactions and antibacterial antifungal activity of sulfur derivatives of pyridazinone].
Oxidative reactions of o-nitrophenylthio substituted 2-phenyl-3(2H)-pyridazinones (3, 4, 13) with hydrogen peroxide were examined and o-nitrophenylsulfinyl compounds (5, 7, 14) and o-nitrophenylsulfonyl compound (6) were obtained. As the results of antibacterial antifungal screening tests in vitro, 3, 5 and 6 revealed strong antitrichophyton activities.
Takaya
M
M
Hamari Chemical Co., Ltd., Osaka, Japan.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D011724:Pyridazines / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011724:Pyridazines; C055256:2-phenyl-3(2H)-pyridazinone