[Effect of treatment with indobufen on blood viscosity indices and exercise tolerance in patients with coronary disease].
The study included 20 patients aged from 50 to 65 years with stable coronary disease. In all patients exercise ECG test in Quinton moving track was performed before the treatment, and after one, three, and eight weeks of therapy. Besides that, before the treatment, and after each exercise, platelet aggregation, viscosity of whole blood and plasma, and filtration time of 1 ml of whole blood were evaluated. It was found that already after one week of treatment indobufen caused a decrease of platelet aggregation, reduction of viscosity of whole blood and plasma, and improvement of erythrocyte compliance which favourable effects increased with the continuation of the therapy up to eight weeks. At the same time as a result of eight weeks of treatment a significant improvement was achieved of exercise tolerance in the treated patients.
Rdzanek
H
H
Oddziału Kardiologii Centralnego Szpitala Klinicznego MSW, Warszawie.
Kochmański
M
M
Zochowski
R J
RJ
D000328:Adult; D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D010654:Phenylbutyrates / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; C020371:indobufen
Wpływ leczenia indobufenem na wskaźniki lepkości krwi i tolerancje wysiłku fizycznego u chorych z choroba wieńcowa.