In vitro action of new organometallic compounds against Trypanosomatidae protozoa.
The effects of 10 newly synthesized organometallic rhodium complexes (5 of Rh(I), 4 of Rh(III) and one of Rh(IV) complex salt) and 2 antimony (III) complexes against epimastigote forms of Trypanosoma cruzi and promastigote forms of Leishmania donovani have been studied in vitro. Of the 10 rhodium complexes tested three proved 100% efficient in inhibiting the growth of the epimastigote forms of T. cruzi while only one worked against the promastigote forms of L. donovani. The two antimony complexes inhibited the growth of L. donovani totally and were fairly successful against T. cruzi.
Mesa-Valle
C M
CM
Departamento de Parasitologia, Facultad de Ciencias, Universidad de Granada, Spain.
Moraleda-Lindez
V
V
Craciunescu
D
D
Alonso
M P
MP
Osuna
A
A
D000818:Animals; D000965:Antimony / Q000494:pharmacology; D007893:Leishmania donovani / Q000187:drug effects / Q000254:growth & development; D009942:Organometallic Compounds / Q000494:pharmacology*; D012238:Rhodium / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000254:growth & development; D014351:Trypanosomatina / Q000187:drug effects* / Q000254:growth & development
D009942:Organometallic Compounds; D014344:Trypanocidal Agents; D000965:Antimony; D012238:Rhodium