New amino sugar analogues are incorporated at different rates into glycoproteins of mouse organs.
Different radiolabelled N-acyl-derivatives of D-glucosamine were synthesized using D-glucosamine and the respective carbonic acid anhydride. Metabolism of these sugar analogues could be shown in vitro as well as in vivo. After the intraperitoneal administration of these radiolabelled N-acyl-D-glucosamines to mice, their rate of incorporation into glycoproteins of different organs was found to increase markedly with the length of the N-acyl side chain. Highest incorporation was measured in the whole intestine using N-pentanoyl-D-glucosamine as label.
Kayser
H
H
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Germany.
Ats
C
C
Lehmann
J
J
Reutter
W
W
D000117:Acetylglucosamine / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002854:Chromatography, Paper; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D051381:Rats
D006023:Glycoproteins; D005944:Glucosamine; D000117:Acetylglucosamine