Portal vein infusion of cancer chemotherapeutic agent emulsified with Lipiodol in regenerating liver after partial hepatectomy in rats.
Portal vein infusion of aclarubicin (ACR) emulsified with Lipiodol (LP) in regenerating liver after 70% partial hepatectomy in rats was evaluated for its safety and usefulness. DNA synthesis in regenerating liver was transiently suppressed by LP, ACR or LP+ACR, but no obvious inhibition was seen in aminopyrine N-demethylase activity and liver weights. LP significantly enhanced hepatic tissue levels of ACR and its active metabolites by long-term retention in the sinusoidal space. This study demonstrates that in rats LP has a powerful effect on the long-term retention of anticancer agents in the sinusoidal space after infusion into the portal vein, without aggravating hepatic damage by anticancer agents.
Miyazaki
M
M
First Department of Surgery, School of Medicine, Chiba University, Japan.
Suzuki
H
H
Itoh
H
H
Kaiho
T
T
Nakajima
T
T
Andoh
K
K
Anbiru
S
S
Ohtawa
S
S
Ogata
A
A
Yasuda
N
N
D015250:Aclarubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects; D016503:Drug Delivery Systems; D004359:Drug Therapy, Combination; D006498:Hepatectomy; D007262:Infusions, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar
D015250:Aclarubicin; D007459:Iodized Oil; D004247:DNA; D000633:Aminopyrine N-Demethylase