title: Tamoxifen and hypercalcaemia.
abstract: The present case demonstrates the importance of close observation, also of serum calcium, when initiating tamoxifen therapy, especially in patients with known osseous metastases. Hypercalcaemia should also be considered as a possible cause of CNS symptoms in patients newly started on endocrine treatment. Hydration with saline is the first step in the management of hypercalcaemia. In patients with a serum calcium level > 3.50 mmol/l (serum ionised calcium approximately 2.00 mmol/l) hydration should be combined with bisphosphonates.
authors.affiliation: Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Daugaard
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy; D002118:Calcium / Q000097:blood; D018270:Carcinoma, Ductal, Breast / Q000097:blood / Q000188:drug therapy; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D013629:Tamoxifen / Q000009:adverse effects*
chemical_list: D013629:Tamoxifen; D002118:Calcium