[Influence of sodium alginate on the intestinal transit in low birth weight newborn infants].
Sodium alginate (Gaviscon) is used in the management of gastro-oesophageal reflux in infants. No digestive disadvantages have as yet been reported with the use of the Gaviscon formula available in France, which contains neither aluminium hydroxide nor thickener. Twenty-two healthy neonates were prospectively studied before and after Gaviscon treatment in order to characterize their whole gut transit time with the use of a carmine index. The head of the marker appeared within the same time in both experiments but the appearance of the tail was earlier in the treated infants (P < 0.05), without any subsequent clinical consequences. The slight increase shown in the rate of the clearance of the marker from the gut, is likely to be related to a less proximal to distal dispersion of the marker, subsequently to physical changes occurring in the viscous alginate. Frequency and consistency of the stools were unmodified by treatment and accordingly Gaviscon can be regarded as having no deleterious effect on transit time in neonates.
Chouraqui
J P
JP
Département de médecine et réanimation pédiatriques, CHU, Grenoble.
Morer
I
I
Renard
P
P
Bielsky
M C
MC
Richard-Berthe
C
C
Rambaud
P
P
D000464:Alginates / Q000494:pharmacology* / Q000627:therapeutic use*; D000536:Aluminum Hydroxide / Q000494:pharmacology / Q000627:therapeutic use*; D000863:Antacids / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011446:Prospective Studies; D012824:Silicic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D017693:Sodium Bicarbonate / Q000494:pharmacology / Q000627:therapeutic use*
D000464:Alginates; D000863:Antacids; D004338:Drug Combinations; D006603:Hexuronic Acids; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D020723:Glucuronic Acid; D017693:Sodium Bicarbonate
Influence de l'alginate de sodium sur le transit intestinal du nouveau-né de petit poids de naissance.