Effects of alprazolam on cellular immune response to surgical stress in mice.
Mice exposed to surgical stress induced by laparotomy and treated with chronic alprazolam (0.5-2 mg/kg) showed a dose-dependent reduction in stress-induced suppression of the natural killer (NK) cell activity. These immunoenhancing effects of alprazolam were more intense when it administered before the surgery was performed.
Freire-Garabal
M
M
Neuroimmunology University of Santiago (NIMUS), Hospital de Conxo, Santiago de Compostela, Spain.
Núñez
M J
MJ
Balboa
J L
JL
Fernández-Rial
J C
JC
Vallejo
L G
LG
González-Bahillo
J
J
Rey-Méndez
M
M
D000525:Alprazolam / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013312:Stress, Physiological / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D013514:Surgical Procedures, Operative / Q000009:adverse effects
D000525:Alprazolam