title: Nucleolar organizer regions in lymphomas: a quantitative study.
abstract: Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NORs) have been studied in paraffin sections of 76 non-Hodgkin's lymphomas, five normal lymph nodes, and five <<reactive>> lymph nodes. The mean number of nucleolar organizer regions per nucleus was 1.19 (SD:0.09) for normal lymphocytes, 3.04 (SD:0.14) for reactive lymph nodes, 2.79 (SD:0.44) for low-grade lymphomas, 6.33 (SD:1.58) for intermediate-grade lymphomas, and 10.53 (SD:1.97) for high-grade lymphomas. There were highly significant differences in Ag-NOR counts among the groups (p < 0.001). The Ag-NOR regions were often observed in nuclei in areas where nucleoli themselves were invisible. It is suggested that this method is useful in diagnostic histopathology and in differentiation of the grade of lymphomas.
authors.affiliation: Pathology Department, Firat University Medicine Faculty-Elaziğ/Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Yekeler
authors.forename: M R
authors.initials: MR
authors.lastname: Ozercan
authors.forename: A Z
authors.initials: AZ
authors.lastname: Yumbul
authors.forename: M
authors.initials: M
authors.lastname: Ağan
authors.forename: I H
authors.initials: IH
authors.lastname: Ozercan
mesh_terms: D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology*; D016622:Silver Staining