title: Does post-withdrawal cue exposure improve outcome in opiate addiction? A controlled trial.
abstract: A controlled trial studied whether cue exposure prevented relapse in opiate addiction. Subjects were randomly allocated to one of two inpatient treatment settings: a drug dependence unit with a special 10 week program and 4 weeks in a behavioural/general treatment unit without such a program. In each setting, following drug-withdrawal, subjects had either cue exposure for at least six sessions over 3 weeks, or a control condition. Subjects were followed up twice, at about 6 weeks and 6 months post-treatment. 186 subjects were randomly allocated; 69 were assessed post-detoxification, and of these 43 completed cue exposure or control treatments. Cue exposure and control subjects did not differ in cue reactivity. This was evaluated post-treatment for cue exposure subjects and at a comparable time point for controls. All groups showed a significant decrement in cue-elicited craving, withdrawal responses and negative mood. Cue exposure and control subjects did not differ at either of the two follow up interviews.
authors.affiliation: Psychology Department, Institute of Psychiatry, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Dawe
authors.forename: J
authors.initials: J
authors.lastname: Powell
authors.forename: D
authors.initials: D
authors.lastname: Richards
authors.forename: M
authors.initials: M
authors.lastname: Gossop
authors.forename: I
authors.initials: I
authors.lastname: Marks
authors.forename: J
authors.initials: J
authors.lastname: Strang
authors.forename: J A
authors.initials: JA
authors.lastname: Gray
mesh_terms: D000328:Adult; D001521:Behavior Therapy; D003000:Clonidine / Q000627:therapeutic use; D003463:Cues; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000523:psychology / Q000534:rehabilitation / Q000628:therapy*; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D003000:Clonidine