Liposome-encapsulated gentamicin treatment of Mycobacterium avium-Mycobacterium intracellulare complex bacteremia in AIDS patients.
TLC G-65, a liposome-encapsulated gentamicin, was given intravenously twice weekly for 4 weeks to AIDS patients with Mycobacterium avium-M. intracellulare complex (MAC) bacteremia at 1.7 mg of gentamicin per kg of body weight per infusion (4 patients), 3.4 mg/kg (10 patients), and 5.1 mg/kg (7 patients). MAC colony counts in blood fell by 75% or more in all three groups (P < 0.005). Drug resistance did not emerge during the study period. Transient renal insufficiency developed in one patient; no other adverse effects were detected. Liposome-encapsulated gentamicin is a potential therapy for MAC infections in AIDS patients.
Nightingale
S D
SD
Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103.
Saletan
S L
SL
Swenson
C E
CE
Lawrence
A J
AJ
Watson
D A
DA
Pilkiewicz
F G
FG
Silverman
E G
EG
Cal
S X
SX
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial; D004337:Drug Carriers; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008081:Liposomes; D008297:Male; D015269:Mycobacterium avium Complex / Q000187:drug effects / Q000254:growth & development; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
D004337:Drug Carriers; D005839:Gentamicins; D008081:Liposomes