[Effect of penicillamine treatment on the occurrence of heart rhythm disturbances in patients with rheumatoid arthritis].
An ECG examination, prolonged over several hours was carried out in 30 patients aged from 29 to 66 years (mean age 51.3) with the diagnosis of rheumatoid arthritis made on the basis of the WHO criteria, before, and in the second and third month of treatment with penicillamine. The values were evaluated of the mean, minimal, and maximal heart rate per minute, and supraventricular and ventricular heart rhythm disturbances, and also conduction disturbances were assessed. In the study no statistically significant changes were recorded in the individual periods of the examination of the values of mean, minimal and maximal heart rate/min. In the initial examination, supraventricular arrhythmia occurred in 80% of patients, and ventricular arrhythmia in 33% of cases. As a result of the applied treatment a decrease was observed of incidence of arrhythmia both supraventricular and ventricular.
Banasiak
W
W
Kliniki Chorób Wewnetrznych Wojskowego Szpitala Klinicznego, Wrocławiu.
Pater
J
J
Telichowski
C
C
Metner
E
E
Petruk-Kowalczyk
J
J
Telichowski
A
A
D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use*
D010396:Penicillamine
Wpływ leczenia penicylamina na wystepowanie zaburzeń rytmu u chorych z reumatoidalnym zapaleniem stawów.