Efferent synapse mechanisms in chick hair cells.
Electrical stimulation of the efferent fiber to the hair cell is known to suppress peripheral auditory function. In isolated hair cells from the chick, acetylcholine (ACh) generated membrane hyperpolarization when a puff was applied at concentrations from 1 microM to 5 mM. Ionophoretic application of ACh generated a membrane hyperpolarization with a rapid time course. This is due to the increase of K conductance and is accompanied by the rise of the [Ca]i.
Ohmori
H
H
Department of Physiology, Faculty of Medicine, University of Kyoto, Japan.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000502:physiology; D002645:Chickens; D004525:Efferent Pathways / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
D000109:Acetylcholine; D002118:Calcium