title: New approaches in the treatment of hypertensive intracerebral hemorrhage.
abstract: A comparison of the long-term outcome after surgical and nonsurgical treatment of hypertensive putaminal hemorrhage was performed in Japan over the last 15 years to determine the appropriate role of surgery. The overall results show a poor response to surgical treatment, but neurosurgeons also know that hematoma evacuation may bring about a dramatic result in some cases. In addition, experimental studies have shown that hematoma evacuation improves neuronal function at the penumbra. The discrepancy between the results of this study and the neurosurgeon's clinical impression is probably a reflection of the following. In the past, the decision to operate was determined mainly by the location of the hemorrhage as determined by computed tomography and/or magnetic resonance imaging. However, this method of deciding surgical indications is probably not correct. We are trying to change the method of determining the surgical indications from morphological to physiological criteria as follows: All patients are initially treated with hyperbaric oxygen, and those who show improvement of their symptoms are clearly indicated for surgery. If the somatosensory evoked potential or auditory brain stem response shows an improvement after administration of mannitol or glycerol, this is also an indication that surgery should be performed.
authors.affiliation: Department of Neurosurgery, School of Medicine, Fujita Health University, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kanno
authors.forename: J
authors.initials: J
authors.lastname: Nagata
authors.forename: K
authors.initials: K
authors.lastname: Nonomura
authors.forename: T
authors.initials: T
authors.lastname: Asai
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: F
authors.initials: F
authors.lastname: Mitsuyama
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D002794:Choline / Q000378:metabolism; D004285:Dogs; D005071:Evoked Potentials; D006406:Hematoma / Q000378:metabolism; D006454:Hemoglobins / Q000502:physiology; D006801:Humans; D006931:Hyperbaric Oxygenation; D006973:Hypertension / Q000150:complications*; D007432:Intraoperative Period; D008991:Monitoring, Physiologic; D009462:Neurology / Q000639:trends; D009474:Neurons / Q000502:physiology; D011581:Psychological Tests; D011699:Putamen / Q000098:blood supply; D013238:Stereotaxic Techniques
chemical_list: D006454:Hemoglobins; D002794:Choline