title: Selenium status of infants is influenced by supplementation of formula or maternal diets.
abstract: Plasma selenium of infants fed proprietary formula was significantly less than that in infants fed human milk. Addition of selenite to the formula (0.253 mumol Se/L) increased plasma selenium and activities of glutathione peroxidase (GPx) and total peroxidase (Px). However, erythrocyte selenium decreased significantly during the 12-wk study in infants receiving human milk or formula with or without supplemental selenite. Infants fed human milk from women receiving 0 or 200 micrograms supplemental selenium as selenomethionine or selenium-enriched yeast had plasma selenium that paralleled changes in their selenium intake. Plasma GPx and Px activities were unrelated to human milk selenium intake. Milk from women given either selenium supplement prevented the decline in infant erythrocyte selenium. Results of these studies suggest that the method of feeding modifies the infant's apparent selenium status and that the molecular form of selenium provided and/or its interaction with other milk constituents are determinants of infant selenium status.
authors.affiliation: Division of Nutritional Sciences, University of Illinois at Urbana-Champaign.
authors.forename: M K
authors.initials: MK
authors.lastname: McGuire
authors.forename: S L
authors.initials: SL
authors.lastname: Burgert
authors.forename: J A
authors.initials: JA
authors.lastname: Milner
authors.forename: L
authors.initials: L
authors.lastname: Glass
authors.forename: R
authors.initials: R
authors.lastname: Kummer
authors.forename: R
authors.initials: R
authors.lastname: Deering
authors.forename: R
authors.initials: R
authors.lastname: Boucek
authors.forename: M F
authors.initials: MF
authors.lastname: Picciano
mesh_terms: D000886:Anthropometry; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007223:Infant; D007225:Infant Food; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D008895:Milk, Human; D012643:Selenium / Q000097:blood*; D012645:Selenomethionine / Q000494:pharmacology; D018038:Sodium Selenite / Q000494:pharmacology; D015003:Yeasts
chemical_list: D012645:Selenomethionine; D005979:Glutathione Peroxidase; D012643:Selenium; D018038:Sodium Selenite