title: Crowding-induced organization of cytoskeletal elements: I. Spontaneous demixing of cytosolic proteins and model filaments to form filament bundles.
abstract: The theory for the effects of crowding on the behavior of reversibly self-assembling solutes is extended to mixtures containing nonassembling solutes. The theory predicts that excluded volume will cause dramatic demixing into domains of long, tightly packed, highly aligned fibers coexisting with an isotropic solution of unaggregated species. It suggests that the bundling of fibers in cells is entropically driven and that accessory binding proteins in the cytoplasm serve to modulate the process rather than create it.
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, Massachusetts 02254-9110.
authors.forename: T L
authors.initials: TL
authors.lastname: Madden
authors.forename: J
authors.initials: J
authors.lastname: Herzfeld
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D003599:Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D003600:Cytosol / Q000378:metabolism; D046911:Macromolecular Substances; D008954:Models, Biological; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D012996:Solutions; D013816:Thermodynamics
chemical_list: D046911:Macromolecular Substances; D011506:Proteins; D012996:Solutions