title: Ten years of experience with patients with chronic active liver disease variceal bleeding: ablative versus selective decompressive therapy.
abstract: BACKGROUND
  Variceal hemorrhage is an added major threat to survival in patients with chronic active liver disease (CALD). The hemodynamic consequences of surgical therapy and the continued activity of the underlying liver disease both contribute to the hepatic dysfunction and determine patient survival.
  
  
  METHODS
  Two hundred and seventy two consecutive cases of (Child A or B) variceal bleeding with chronic hepatitis were surgically treated during a 10-year period. Histologic chronic active hepatitis (CAH) was documented in 160 (59%) patients, whereas chronic persistent hepatitis (CPH) was evident in 112 (41%). The applied surgical procedure was distal splenorenal shunt (DSRS) in 99 (36%) patients, splenectomy and gastroesophageal devascularization (SGD) in 108 (40%), and splenectomy with left gastric ligation (SLGL) in 65 (24%) patients. The preoperative data base obtained on these patients was matched comparing the three surgical modalities within each pathologic group (p > 0.05).
  
  
  RESULTS
  The operative mortality was low among the patients with CAH (DSRS, 5.1%; SGD, 4.2%) with no deaths occurring in the CPH group. Among the individuals with CAH, recurrent variceal hemorrhage occurred significantly (p < 0.05) more often after SLGL (26%) and SGD (17%) than after DSRS (5%). Sclerotherapy rescued 93% (SGD) and 70% (SLGL) of the patients with rebleeding. DSRS significantly (p < 0.05) increased the risk of encephalopathy (28%) compared with SGD (4.2%) and SLGL (8%). The morbidity rates were quite low among the patients with CPH with no significant (p > 0.05) differences noted when the three surgical modalities were compared. Both groups experienced a significant (p < 0.05) increase in aspartate aminotransferase levels after the three procedures with a significant (p < 0.05) increase in bilirubin level occurring only after DSRS. The 5-year survival rate for the patients with variceal bleeding with CAH was 76% (DSRS), 73% (SGD), and 88% (SLGL). The leading causes of death were liver failure after DSRS (70%), variceal hemorrhage after SLGL (60%), and equally divided between septicemia (43%) and liver failure (43%) after SGD. The patients with CPH had a better 5-year survival of 89% (DSRS) and 100% (nonshunt operation).
  
  
  CONCLUSIONS
  These data showed that (1) CALD is common among cases of variceal bleeding; (2) elective surgical treatment of variceal hemorrhage in patients with Child A or B CALD has a low operative mortality; (3) SLGL backed up by sclerotherapy is a better surgical alternative to either selective shunt or SGD in patients with active hepatitis, and (4) both DSRS and nonshunt operation are equally good surgical options for patients with CPH.
authors.affiliation: Department of Surgery, Mansoura University School of Medicine, Egypt.
authors.forename: K M
authors.initials: KM
authors.lastname: Abu-Elmagd
authors.forename: M A
authors.initials: MA
authors.lastname: Aly
authors.forename: O M
authors.initials: OM
authors.lastname: Fathy
authors.forename: N A
authors.initials: NA
authors.lastname: E-Ghawlby
authors.forename: A M
authors.initials: AM
authors.lastname: el-Fiky
authors.forename: M H
authors.initials: MH
authors.lastname: el-Barbary
authors.forename: N G
authors.initials: NG
authors.lastname: el-Hak
authors.forename: G E
authors.initials: GE
authors.lastname: el-Ebady
authors.forename: A
authors.initials: A
authors.lastname: Sultan
authors.forename: O O
authors.initials: OO
authors.lastname: Bahgat
mesh_terms: D000328:Adult; D002908:Chronic Disease; D017558:Elective Surgical Procedures; D004932:Esophageal and Gastric Varices / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D004947:Esophagus / Q000098:blood supply; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D006521:Hepatitis, Chronic / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D011183:Postoperative Complications; D012008:Recurrence; D013156:Splenectomy; D013164:Splenorenal Shunt, Surgical; D013270:Stomach / Q000098:blood supply / Q000601:surgery; D015996:Survival Rate