title: Efficacy of meclofenamate sodium (Meclomen) in the treatment of rapidly progressive periodontitis.
abstract: This 6-month, double-blind, controlled clinical trial determined the efficacy of the non-steroidal anti-inflammatory drug, meclofenamate sodium (Meclomen), as an adjunct to scaling and root planing in the treatment of rapidly progressive periodontitis (RPP). 22 subjects (7 male, 15 female) aged 36.5 +/- 7.88 years with RPP and disease-active sites as determined by pretreatment bone scan had standardized radiographs at baseline and 6 months, and clinical measurements at baseline, 3 and 6 months. Following full-mouth scaling and root planing, subjects were randomly assigned to either a placebo, 50 or 100 mg meclofenamate sodium bid group. Bone change over the 6-month period as assessed by subtraction radiography was the primary efficacy determinant. Specialized software was used to isolate the lesion from the subtraction image and to measure bone change along the root surface. ANOVA using the subject as the unit of analysis revealed a significant dose response (p < 0.001) with the placebo group having a mean bone loss of 0.42 +/- 0.06 mm and the low and high dose groups having mean bone gains of 0.07 +/- 0.05 and 0.20 +/- 0.07 mm, respectively. These findings indicate that meclofenamate sodium may be a useful adjunct in the treatment of rapidly progressive periodontitis.
authors.affiliation: University of Alabama School of Dentistry, Birmingham.
authors.forename: M S
authors.initials: MS
authors.lastname: Reddy
authors.forename: K G
authors.initials: KG
authors.lastname: Palcanis
authors.forename: M L
authors.initials: ML
authors.lastname: Barnett
authors.forename: S
authors.initials: S
authors.lastname: Haigh
authors.forename: C H
authors.initials: CH
authors.lastname: Charles
authors.forename: M K
authors.initials: MK
authors.lastname: Jeffcoat
mesh_terms: D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008469:Meclofenamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy / Q000473:pathology; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010919:Placebos; D011859:Radiography; D011877:Radionuclide Imaging; D013382:Subtraction Technique; D013669:Technetium Tc 99m Medronate
chemical_list: D010919:Placebos; D008469:Meclofenamic Acid; D013669:Technetium Tc 99m Medronate