[Changes in regulatory peptides at different stages of essential hypertension and their clinical significance].
The changes of regulatory peptides in 100 patients with essential hypertension at different stages were studied. Four kinds of peptides in serum were measured by RIA method. The results showed that: (1) neurotensin, P-substances, beta-endorphin and leucine-enkephalin decreased significantly in the group (P < 0.01). (2) the levels of those parameters at different stages of hypertension were decreased in parallel with its severity and the difference between different stages is significant (P < 0.01). (3) norepinephrine showed negative correlation with four kinds of neuropeptides. (4) neurotensin, Beta-endorphin and leucine-enkephalin increased significantly after capton (P < 0.01). The possible mechanism and its clinical significance of the changes of those regulatory peptides in hypertension patients were discussed.
Jiang
S S
SS
Nanjing General Hospital, PLA.
D002216:Captopril / Q000627:therapeutic use; D004743:Enkephalin, Leucine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D009479:Neuropeptides / Q000097:blood*; D009496:Neurotensin / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D001615:beta-Endorphin / Q000097:blood
D009479:Neuropeptides; D009496:Neurotensin; D004743:Enkephalin, Leucine; D001615:beta-Endorphin; D002216:Captopril; D009638:Norepinephrine