Constituents of rosaceous plants. I. Structure of new triterpenoids from Cowania mexicana.
In our search for possible anti-tumor-promoters, we carried out an investigation of the leaves and branches of Cowania mexicana D. DON (Rosaceae). Two new cucurbitane type triterpenes, 15-oxo-cucurbitacin F (3) and 15-oxo-23,24-dihydrocucurbitacin F (4), were isolated together with cucurbitacin F (1) and 23,24-dihydrocucurbitacin F (2). These triterpenes were inhibitorss of Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate, a well-known tumor-promoter. The structures of 3 and 4 were determined from 2D-NMR spectral data and difference NOE experiments.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan.
Takasaki
M
M
Kozuka
M
M
Haruna
M
M
Ito
K
K
Estes
J R
JR
Lee
K H
KH
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000276:immunology; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D014315:Triterpenes