Speculations on the roles of ADP-ribosyl transferase based on analogies between RecA and poly(ADP-ribose) polymerase.
A model for eukaryotic DNA damage repair is proposed in which poly(ADP-ribose) polymerase(NAD+ ADP-ribosyl transferase, EC 2,4,2,30) plays an important role. In this model, poly(ADP-ribose) polymerase regulates transcription of genes that are induced by DNA-damaging agents. This transcriptional regulation results from poly(ADP-ribosyl)ation and inactivation of DNA sequence-specific regulatory proteins such as silencer element-binding proteins, thereby inducing transcription of DNA polymerase beta, which is a DNA repair enzyme in higher eukaryotes. Poly(ADP-ribose) polymerase has a number of similarities to RecA in Escherichia coli. Therefore, the genes related to DNA damage repair in higher eukaryotes are proposed to form a "poly(ADP-ribose) polymerase regulatory network" similar to the "SOS regulatory network" in E. coli.
Matsumoto
J
J
Department of Chemistry, University of Massachusetts, Amherst 01003.
D000818:Animals; D004256:DNA Polymerase I / Q000502:physiology; D004260:DNA Repair / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics; D008957:Models, Genetic; D011065:Poly(ADP-ribose) Polymerases / Q000502:physiology*; D011938:Rec A Recombinases; D013014:SOS Response, Genetics / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D011065:Poly(ADP-ribose) Polymerases; D011938:Rec A Recombinases; D004256:DNA Polymerase I