title: Characterization of the products of dinucleoside monophosphates d(GpN) irradiated in aqueous solutions.
abstract: The dinucleoside monophosphates d(GpT), d(GpC), and d(GpA) were X-irradiated in oxygenated aqueous solution. The principal products were identified in the intact modified dinucleoside monophosphates using NMR spectroscopy and FAB mass spectrometry. The 8-hydroxyguanine modification is a major product in each of the d(GpN). The d(GpN), where N is a pyrimidine nucleoside, also yield products in which the pyrimidine base is degraded to a formamido remnant. The most interesting product is one bearing two base damages, 8-hydroxylation of the guanine base and degradation of the pyrimidine base to a formamido remnant. This double lesion was observed in both d(GpN) where N is a pyrimidine base.
authors.affiliation: Department of Experimental Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263.
authors.forename: E E
authors.initials: EE
authors.lastname: Budzinski
authors.forename: A E
authors.initials: AE
authors.lastname: Maccubbin
authors.forename: H G
authors.initials: HG
authors.lastname: Freund
authors.forename: J C
authors.initials: JC
authors.lastname: Wallace
authors.forename: H C
authors.initials: HC
authors.lastname: Box
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004249:DNA Damage; D015226:Dinucleoside Phosphates / Q000528:radiation effects*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D015226:Dinucleoside Phosphates