Endothelin-1 and okadaic acid induced contractions in tracheal smooth muscle of lamb.
Stimulation of lamb tracheal smooth muscle fibre strips with endothelin-1 and okadaic acid results in the development of isometric tensions which are long lasting. However, endothelin-1 is more potent constrictor than okadaic acid. An analysis of 20,000 Da regulatory myosin light chain by two-dimensional gel electrophoresis shows an identical phosphorylation pattern.
Katoch
S S
SS
II Physiology Institute, University of Heidelberg, Germany.
D000818:Animals; D016232:Endothelins / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D019319:Okadaic Acid; D012756:Sheep; D014132:Trachea
D016232:Endothelins; D004988:Ethers, Cyclic; D019319:Okadaic Acid