(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists.
Dhanoa
D S
DS
Department of Exploratory Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065.
Bagley
S W
SW
Chang
R S
RS
Lotti
V J
VJ
Chen
T B
TB
Kivlighn
S D
SD
Zingaro
G J
GJ
Siegl
P K
PK
Chakravarty
P K
PK
Patchett
A A
AA
D000804:Angiotensin II / Q000494:pharmacology; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001713:Biphenyl Compounds / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D007093:Imidazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D019808:Losartan; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011945:Receptors, Angiotensin / Q000378:metabolism; D013777:Tetrazoles / Q000494:pharmacology
D057911:Angiotensin Receptor Antagonists; D001713:Biphenyl Compounds; D007093:Imidazoles; D010648:Phenylacetates; D011945:Receptors, Angiotensin; D013777:Tetrazoles; D000804:Angiotensin II; C084481:alpha-((1-((2-ethyl-5,7-dimethylimidazo(4,5-b)pyridin-3-yl)methyl)-3,5-dipropylphenyl-4-yl)oxy)phenylacetic acid; C070967:L 158809; D019808:Losartan