Non-Hodgkin's malignant lymphoma of the bone with intracavitary cardiac involvement.
An 84-year-old man with non-Hodgkin's malignant lymphoma presented with a pathological fracture of the femur and also an intra-atrial mass on echocardiography. The patient was given palliative low-dose chemotherapy, but died of tumor dissemination, hypercalcemia, and dehydration. Autopsy revealed diffuse large B-cell lymphoma involving multiple bones and lymph nodes (the latter were not detected during staging), and a solitary mass on the posterior wall of the right atrium. This rare lesion appeared to be due to hematogenous spread, since the myocardium and pericardium were free of tumor infiltration. A literature review indicated that the frequency of cardiac involvement differed between contemporary and earlier reports, mainly due to the availability of increasingly sophisticated diagnostic methods and improvements in chemotherapy.
Sato
H
H
Department of Internal Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
Takahashi
M
M
D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell; D017809:Fatal Outcome; D005264:Femoral Fractures / Q000209:etiology; D005266:Femoral Neoplasms / Q000150:complications / Q000556:secondary*; D005598:Fractures, Spontaneous / Q000209:etiology; D006338:Heart Neoplasms / Q000556:secondary*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary; D009382:Neoplasms, Unknown Primary; D001749:Urinary Bladder Neoplasms