Myocardial atrial natriuretic factor gene expression after coronary ligation in rats.
The atrial natriuretic factor (ANF) messenger RNA (mRNA) content was determined in a rat model of acute myocardial infarction. Non-infarcted tissue of left and right ventricles were examined soon after ligation of the left descending anterior coronary artery. In the left ventricles, ANF mRNA/alpha-actin mRNA ratio increased to reach a maximum on day 7 and was sustained while in the right ventricle, the maximum was reached on day 1. The plasma ANF was significantly (p < 0.01) elevated from days 1 to 28 after coronary ligation. The primary compensatory response of ANF within the first 7 days may be attributed not only its synthesis in the left ventricle but also to its generation in the right ventricle in acute heart failure.
Kanda
T
T
2nd Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Nakano
M
M
Arai
M
M
Yamamoto
A
A
Suzuki
T
T
Murata
K
K
D000199:Actins / Q000096:biosynthesis; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D015152:Blotting, Northern; D003331:Coronary Vessels / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology*; D005802:Genes, MHC Class II; D006333:Heart Failure / Q000378:metabolism; D006352:Heart Ventricles / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
D000199:Actins; D012333:RNA, Messenger; D009320:Atrial Natriuretic Factor