The effect of peripheral inositol injection on rat motor activity models of depression.
Myo-inositol is an important precursor in cellular second-messenger synthesis. It has been reported to be reduced in the cerebrospinal fluid of depressed patients and to reverse a specific effect of Li on rat behavior when given intracerebroventricularly (i.c.v.). However, myo-inositol enters the brain poorly when given peripherally, and its effects on normal rat brain have not been well studied. A series of experiments examined the effect of intraperitoneal inositol in high doses on locomotor activity, on amphetamine-induced hyperactivity, on apomorphine-induced stereotyped behavior, and on pilocarpine-induced behaviors in rats. In addition, the behavioral effect of i.c.v. inositol was compared to that of a control stereoisomer in untreated and lithium-treated rats. Few effects of peripheral myo-inositol were found in these models. However, peripheral inositol in high doses given to rats exhibiting Li-pilocarpine seizures showed that i.p. inositol could prevent these behaviors, confirming that peripheral inositol may have antidepressant potential in appropriate models.
Kofman
O
O
Department of Behavioral Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Bersudsky
Y
Y
Vinnitsky
I
I
Alpert
C
C
Belmaker
R H
RH
D000661:Amphetamine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003863:Depression / Q000523:psychology*; D004195:Disease Models, Animal; D004357:Drug Synergism; D005947:Glucose / Q000494:pharmacology; D007294:Inositol / Q000494:pharmacology*; D008094:Lithium / Q000037:antagonists & inhibitors; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D013239:Stereotyped Behavior / Q000187:drug effects
D010862:Pilocarpine; D007294:Inositol; D008094:Lithium; D000661:Amphetamine; D005947:Glucose; D001058:Apomorphine