Acute anuric renal failure: a complication of combined thrombolytic and antithrombotic therapy.
Thrombolytic agents are routinely given to patients with acute myocardial infarction, often in combination with heparin. Genitourinary hemorrhage is an uncommon adverse effect of systemic thrombolysis, and acute azotemic complications are distinctly rare. We describe a case of genitourinary hemorrhage after combined thrombolytic and antithrombotic therapy leading to acute bilateral ureteral obstruction and then briefly review renal complications of systemic thrombolysis.
Toupin
L R
LR
Department of Internal Medicine, University of California, San Diego School of Medicine.
Blanchard
D G
DG
D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D015906:Angioplasty, Balloon, Coronary; D001002:Anuria / Q000097:blood / Q000139:chemically induced*; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006417:Hematuria / Q000097:blood / Q000139:chemically induced; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D010314:Partial Thromboplastin Time; D013300:Streptokinase / Q000009:adverse effects* / Q000627:therapeutic use; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D014517:Ureteral Obstruction / Q000097:blood / Q000139:chemically induced; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects
D006493:Heparin; D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator; D001241:Aspirin