Prenatal toxicity of xylene inhalation in the rat: a teratogenicity and postnatal study.
Technical xylene (cas. nr. 1330-20-7) was investigated for development toxicity in a teratology and in a postnatal study. Rats (Mol: WIST) were exposed to 500 p.p.m. 6 hr per day on days 4 to 20 of gestation. There were no signs of maternal toxicity. In the teratology study, no exposure-related differences were found except for delayed ossification of os maxillare. In the postnatal study, the xylene-exposed pups had a higher body weight and an impaired performance on a motor ability test (Rotarod). Due to the possibility of direct toxic effects of xylene on the developing central nervous system, further studies are needed to investigate dose-effect relationship for this type of effects.
Hass
U
U
Department of Toxicology and Biology, National Institute of Occupational Health, Copenhagen O, Denmark.
Jakobsen
B M
BM
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000280:Administration, Inhalation; D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013723:Teratogens / Q000633:toxicity*; D014992:Xylenes / Q000633:toxicity*
D013723:Teratogens; D014992:Xylenes