[Iatrogenic axonal neuropathy and erythroderma induced by piroxicam. Manifestations of hypersensitivity?].
A case of peripheral neuropathy following treatment with piroxicam is reported. The patient developed muscle pain and asymmetrical sensory distal neuropathy of the lower limbs a few months after the onset of the treatment. Piroxicam was withdrawn and full recovery was achieved within one year. The simultaneous appearance in the same patient of erythroderma with microvasculitis on nerve and skin biopsies suggests a common type III hypersensitivity mechanism in the pathogenesis of these two side-effects of piroxicam.
Sangla
I
I
Clinique des maladies du système nerveux et de l'appareil locomoteur, CHU Timone.
Blin
O
O
Jouglard
J
J
Cottin
C
C
Berbis
P
P
Pellissier
J F
JF
Serratrice
G
G
D000368:Aged; D001369:Axons; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D010894:Piroxicam / Q000009:adverse effects*
D010894:Piroxicam
Neuropathie axonale et toxidermie iatrogène par le piroxicam. Manifestations d'hypersensibilité?