Linkage of the gene for uncoupling protein to esterase-1,2 and haptoglobin in the rat.
Genetic analysis of a (BN x ACI)ACI backcross for the biochemical markers Es-1 and Es-2 (linkage group V) and a microsatellite marker of Ucp (chromosome 19) revealed linkage between these three loci. This linkage relationship confirms that in the rat linkage group V genes are located on chromosome 19. Genetic analysis of a (BN x LEW)LEW backcross showed that Hp is linked to Ucp, thus indicating that the Hp locus is also located on chromosome 19. These results substantiate the linkage homology of RNO 19, MMU 8, and HSA 16.
Otsen
M
M
Department of Laboratory Animal Science, University of Utrecht, The Netherlands.
Den Bieman
M
M
van Zutphen
L F
LF
D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D003433:Crosses, Genetic; D017931:DNA Primers; D004950:Esterases / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006242:Haptoglobins / Q000235:genetics*; D007473:Ion Channels; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D051381:Rats; D011919:Rats, Inbred Strains; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D017931:DNA Primers; D006242:Haptoglobins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1; D004950:Esterases