title: Advances in the therapy for mastitis.
abstract: Methods to enhance mammary resistance to bacterial infection and to reduce the effects of existing infections without the use of antimicrobial agents are becoming more attractive, primarily because of increasing pressure from consumers and regulatory agencies to decrease the risk of drug residues in milk. Because of the difficulty in obtaining satisfactory results with existing drug formulations, new approaches in the treatment of mastitis should emphasize better understanding of mammary gland pharmacokinetics, ameliorating the pathologic effects of infection, and enhancing natural defenses. Efficacy studies should emphasize milk production and long-term survival of cows to allow economic evaluations.
authors.affiliation: Department of Large Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing.
authors.forename: R J
authors.initials: RJ
authors.lastname: Erskine
authors.forename: J H
authors.initials: JH
authors.lastname: Kirk
authors.forename: J W
authors.initials: JW
authors.lastname: Tyler
authors.forename: F J
authors.initials: FJ
authors.lastname: DeGraves
mesh_terms: D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002417:Cattle; D004573:Electrolytes / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy / Q000662:veterinary*; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000628:therapy; D013256:Steroids
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004573:Electrolytes; D013256:Steroids