[Smooth muscle cell migration induced by macrophage-derived chemotactic factor].
The chemotactic activity of rabbit peritoneal macrophage condition-medium (M phi-CM) was examined through micropore filter assay. The effects of M phi-CM on smooth muscle cell (SMCS) migration were considered to be chemotactic rather than chemokinetic in nature. This chemotactic activity was heat stable at 80 degrees C for 30 min, but was abolished at 100 degrees C for 15 min. The chemotactic activity was still maintained after dialysis, but was abolished after incubation with trypsin. It is suggested that the chemotactic factor in M phi-CM may be a protein.
Deng
Z D
ZD
Department of Pathology, Tongji Medical University, Wuhan.
D000818:Animals; D001011:Aorta / Q000166:cytology; D001161:Arteriosclerosis / Q000209:etiology; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D016209:Interleukin-8 / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D011817:Rabbits
D017077:Culture Media, Conditioned; D016209:Interleukin-8