Spinal cord transection produces a long-term increase in GABAB binding in the rat substantia gelatinosa.
Quantitative autoradiography was used to determine changes in GABAB receptor binding in the substantia gelatinosa of the lumbar spinal cord at 4 days and at 6 weeks after a midthoracic spinal transection in rats. In the 4 day lesion animals, there was no significant change in either the density or the affinity of the GABAB binding. At 6 weeks, however, there was a 35% increase in binding density, with no significant change in affinity. The results suggest that alterations in spinal synaptic mechanisms can slowly evolve following loss of descending input to the spinal cord.
Kroin
J S
JS
Department of Neurosurgery, Rush Medical College, Chicago, Illinois 60612.
Bianchi
G D
GD
Penn
R D
RD
D000818:Animals; D001345:Autoradiography; D003655:Decerebrate State / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018080:Receptors, GABA-B / Q000378:metabolism* / Q000502:physiology; D013376:Substantia Gelatinosa / Q000033:anatomy & histology / Q000378:metabolism*
D018080:Receptors, GABA-B