Synthesis and biological activity of 2-substituted analogues of 2'-deoxy-2'-fluoroadenosine.
Reaction of 2-iodo-6-methoxypurine 2'-deoxy-2'-fluororiboside with ammonia in methanol gave 2-iodo-adenosine derivative 2 in 69% yield. Treatment of 2 with nucleophiles gave 2-substituted analogues of 2'-deoxy-2'-fluoroadenosine. A new 2'-deoxy-2,2'-difluoroadenosine was also prepared by way of quaternary salt 4.
Maruyama
T
T
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Utsumi
K
K
Sato
Y
Y
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003839:Deoxyadenosines / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure
D000998:Antiviral Agents; D003839:Deoxyadenosines; C030964:2'-fluoro-2'-deoxyadenosine