title: Carcinoma of the papilla of Vater in a brother and sister with familial adenomatous polyposis.
abstract: Familial adenomatous polyposis (FAP) is characterized by the development of adenomas throughout the entire gastrointestinal tract. We describe a brother and sister with FAP who developed adenocarcinoma around the papilla of Vater. Incidence, premalignancy, treatment and the need for prophylactic endoscopy are discussed.
authors.affiliation: Department of Internal Medicine, Medical Centre, Leeuwarden, Netherlands.
authors.forename: R T
authors.initials: RT
authors.lastname: Gerritsen
authors.forename: P
authors.initials: P
authors.lastname: Spoelstra
authors.forename: N G
authors.initials: NG
authors.lastname: Breeuwsma
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000235:genetics; D014670:Ampulla of Vater; D001706:Biopsy; D003138:Common Bile Duct Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010375:Pedigree