[Immunohistochemical studies of islet lesions in Keshan disease patients and rats fed with grains from endemic area of the disease].
Pancreas tissue collected from 77 patients died of Keshan disease as well as pancreas specimens of experimental rats having been fed with grains collected from Keshan disease endemic area were studied with immunohistochemical stainings. There were lesions found morphologically in the pancreatic islets of the patients, including atrophy, reduction of number, abnormal arrangement and degeneration of the islet cells. The serum insulin and connective peptide levels as well as the connective peptide secretory reserve in the islets of rats fed with endemic area grains were all markedly decreased. These findings suggest that the islet lesions in Keshan disease may be an important factor in aggravating the development of necrosis in the myocardium.
Zhang
G Z
GZ
Institute of Endemic Disease, Norman Bethune University of Medical Sciences.
D000293:Adolescent; D000818:Animals; D001284:Atrophy; D002096:C-Peptide / Q000378:metabolism; D009202:Cardiomyopathies / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D010179:Pancreas / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000172:deficiency*; D018038:Sodium Selenite / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D002096:C-Peptide; D007328:Insulin; D014810:Vitamin E; D012643:Selenium; D018038:Sodium Selenite