title: [Epstein-Barr virus infection and syndrome of inappropriate macrophage activation].
abstract: An 11-year-old girl presented with a typical serologically proven infectious mononucleosis with persistent fever, jaundice and hepatosplenomegaly in spite of steroid therapy. Laboratory tests showed pancytopenia, fibrinopenia and hypertriglyceridemia. The liver biopsy revealed an infiltration with hyperbasophilic cells. One month later, a slight improvement was noted and fever disappeared after 4 days on acyclovir therapy. The authors recall the spectrum of the macrophagic activation syndrome.
authors.affiliation: Services de pédiatrie et néonatalogie, CHRU, Nîmes, France.
authors.forename: R
authors.initials: R
authors.lastname: Guillaud
authors.forename: J F
authors.initials: JF
authors.lastname: Schved
authors.forename: J C
authors.initials: JC
authors.lastname: Gris
authors.forename: H
authors.initials: H
authors.lastname: Chapuis
authors.forename: C
authors.initials: C
authors.lastname: Marty-Double
authors.forename: J
authors.initials: J
authors.lastname: Astruc
authors.forename: D
authors.initials: D
authors.lastname: Lesbros
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D002648:Child; D005260:Female; D005334:Fever / Q000209:etiology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications / Q000276:immunology*; D008262:Macrophage Activation; D010198:Pancytopenia / Q000209:etiology; D010587:Phagocytosis; D013577:Syndrome
chemical_list: D000212:Acyclovir
vernacular_title: Infection à virus Epstein-Barr et syndrome d'activation macrophagique inappropriée.