title: [Early effects of neutron-gamma or gamma irradiation on the group toxicity induced by (+) amphetamine in mice].
abstract: To better understand the mechanism of action of gamma and neutron radiation on the dopaminergic system, the influence of the two irradiation modalities on the group toxicity of (+) amphetamine was studied in mice. Neutron-gamma irradiation (3.6-4.95 Gy) leads to an early toxicity reduction, while gamma-exposure (7-12 Gy) induces an increase in toxicity. This suggests that these two types of radiation induce different early effects on central dopaminergic system. Possible mechanisms are discussed.
authors.affiliation: Unités de Radioprotection et de Biomathématiques et Informatique, Centre de Recherches du Service de Santé des Armées, Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: D
authors.initials: D
authors.lastname: Janodet
authors.forename: A
authors.initials: A
authors.lastname: Job
authors.forename: M
authors.initials: M
authors.lastname: Eschenbrenner
authors.forename: M
authors.initials: M
authors.lastname: Fatôme
mesh_terms: D000206:Actuarial Analysis; D000661:Amphetamine / Q000528:radiation effects / Q000633:toxicity*; D000818:Animals; D004298:Dopamine / Q000502:physiology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D051379:Mice; D009502:Neutrons
chemical_list: D000661:Amphetamine; D004298:Dopamine
vernacular_title: Effets précoces de l'irradiation neutron-gamma ou gamma sur la toxicité de groupe induite par la (+) amphétamine chez la souris.