title: Single-lung retransplantation for late graft failure.
abstract: In lung or heart-lung recipients, an irreversible graft-failure may develop in connection with chronic rejection, infection or bronchial complications. A limited number of transplant-recipients have undergone a retransplantation procedure in several centres. First results are discouraging, especially in the case of early retransplantation. We decided, 3 yrs ago, to evaluate the feasibility and benefits of single-lung retransplantation in lung-transplant recipients with late graft-failure. Eight consecutive single-lung retransplantations were performed in patients with previous single-lung (n = 7), or double-lung (n = 1) transplant. Primary graft and native lung were removed in 5 and 3 patients, respectively. The delay between the two surgical procedures was 16 +/- 10 months (range 6-37 months). Three patients died within 3 months. Long-term survivors experienced stable and satisfactory functional results (forced expiratory volume in one second (FEV1 63 +/- 21% predicted; range 40-103% predicted), with survival values ranging 8-20 months. One patient died of septic shock 16.5 months after retransplantation. The remaining four patients are alive. These data suggest that the retransplantation option could be considered in selected patients with late graft-failure. The final decision for retransplantation, however, is largely influenced by the current shortage of donor lungs.
authors.affiliation: Service de Pneumologie et Réanimation, INSERM U226, Hôpital Beaujon, Clichy, France.
authors.forename: M
authors.initials: M
authors.lastname: Fournier
authors.forename: C
authors.initials: C
authors.lastname: Sleiman
authors.forename: H
authors.initials: H
authors.lastname: Mal
authors.forename: O
authors.initials: O
authors.lastname: Groussard
authors.forename: J L
authors.initials: JL
authors.lastname: Mollo
authors.forename: J P
authors.initials: JP
authors.lastname: Duchatelle
authors.forename: B
authors.initials: B
authors.lastname: Andreassian
authors.forename: R
authors.initials: R
authors.lastname: Pariente
mesh_terms: D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000601:surgery*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007165:Immunosuppression Therapy; D008173:Lung Diseases, Obstructive / Q000601:surgery; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012129:Respiratory Function Tests; D016019:Survival Analysis; D013997:Time Factors; D017211:Treatment Failure