title: Topical tromantadine in the treatment of genital herpes. A double-blind placebo controlled study.
abstract: A randomised double-blind placebo controlled trial was performed to assess the efficacy and safety of tromantadine ointment 1% in male patients with genital herpes. 45 patients with penile genital herpes of less than three days duration were randomised to local treatment with tromantadine ointment 1% or placebo (ointment base alone) five times daily up to 12 days. No difference in time of healing could be detected between the two groups (p = 1.0). Both the objective signs (vesicles, pustules, ulceration, and glandular swelling) and the subjective symptoms (itching, burning, pain and dysuria) all diminished simultaneously in the two groups.
authors.affiliation: Department of Dermato-Venerology, Bispebjerg Hospital, Copenhagen.
authors.forename: C S
authors.initials: CS
authors.lastname: Petersen
authors.forename: K
authors.initials: K
authors.lastname: Weismann
authors.forename: C
authors.initials: C
authors.lastname: Avnstorp
authors.forename: L P
authors.initials: LP
authors.lastname: Rasmussen
authors.forename: H
authors.initials: H
authors.lastname: Fogh
authors.forename: G
authors.initials: G
authors.lastname: Tikjøb
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000547:Amantadine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D006558:Herpes Genitalis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010409:Penile Diseases / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000998:Antiviral Agents; D000547:Amantadine; C004279:tromantadine