[Effect of interleukin-1 beta on liver/bone/kidney alkaline phosphatase mRNA level of fibroblastic cells derived from human periodontal ligament].
The present study showed the effect of interleukin-1 beta (IL-1 beta) on liver/bone/kidney (L/B/K) alkaline phosphatase (ALP) mRNA level of the fibroblastic cells derived from human periodontal ligament (HPLF). The 5th to 10th passage of cultured HPLF were used. It was found that IL-1 beta significantly inhibited the gene expression of L/B/K ALP mRNA in the cells, and that the effect was dose-and incubation time-dependent. These results suggest that IL-1 beta may play a negative role in reparation of periodontium and periapical diseases.
Niu
Z Y
ZY
College of Stomatology, Fourth Military Medical University, Xi'an.
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000096:biosynthesis / Q000235:genetics*; D002478:Cells, Cultured; D002648:Child; D005347:Fibroblasts / Q000166:cytology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D010513:Periodontal Ligament / Q000166:cytology*; D012333:RNA, Messenger / Q000032:analysis*
D007375:Interleukin-1; D012333:RNA, Messenger; D000469:Alkaline Phosphatase