Mapping of aldose reductase gene sequences to human chromosomes 1, 3, 7, 9, 11, and 13.
Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somatic cell hybridization. By in situ hybridization analysis, sequences were localized to human chromosomes 1q32-q42, 3p12, 7q31-q35, 9q22, 11p14-p15, and 13q14-q21. As a putative functional AR gene has been mapped to chromosome 7 and a putative pseudogene to chromosome 3, the sequences on the other seven chromosomes may represent other active genes, non-aldose reductase homologous sequences, or pseudogenes.
Bateman
J B
JB
Vision Genetics Center, Jules Stein Eye Institute, Los Angeles, California.
Kojis
T
T
Heinzmann
C
C
Klisak
I
I
Diep
A
A
Carper
D
D
Nishimura
C
C
Mohandas
T
T
Sparkes
R S
RS
D000449:Aldehyde Reductase / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D051379:Mice; D011544:Pseudogenes
D018076:DNA, Complementary; D000449:Aldehyde Reductase