[The effect of peridural analgesia on uterine contractions].
OBJECTIVE
To study the impact of 0.25% bupivacaine on the frequency and intensity of uterine contractions.


METHODS
52 patients in labour. Continuous internal tokographic measurement of uterine activity at 10 minutes before instilling the bupivacaine and at 30 minutes after doing so. The true frequency and intensity of the uterine contractions were the two parameters that were studied.


RESULTS
There was a significant variation (matched Student's test) between the two parameters that were studied: there was transitory hypokinesia (p = 0.003) and intense prolonged hyperkinesia (p < 0.001).


CONCLUSIONS
0.25% bupivacaine produces hyperkinetic increases in intensity of the contractions of which the mechanism has not been elucidated; therefore it is inadvisable to add oxytocics in the minutes after instilling bupivacaine.
Marpeau
L
L
Service de Gynécologie Obstétrique, Hôpital Saint-Antoine, Paris.
Jault
T
T
Gauchet
F
F
Barrat
J
J
Milliez
J
J
D015360:Analgesia, Epidural / Q000009:adverse effects*; D016362:Analgesia, Obstetrical / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects*; D015148:Cardiotocography; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007744:Obstetric Labor Complications / Q000188:drug therapy* / Q000503:physiopathology; D010120:Oxytocics / Q000008:administration & dosage; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*
D010120:Oxytocics; D002045:Bupivacaine
Effet de l'analgésie péridurale sur la contraction utérine.