The thyroadrenal axis, food deprivation and retention of a behavioural response.
The effects of adrenalectomy on retention of the immobile response in the Porsolt swimming rat test are equally reversed by dexamethasone, ketocyclazocine and thyroxine; the effects of hypothyroidism are similarly equally well reversed by all three agents, or by adrenalectomy. Animals food deprived for 24 h lose the response, but retain it after 48 h food deprivation; the latter effect is blocked by adrenalectomy. These counterintuitive findings suggest hitherto unrecognized commonalities and/or interactions in the metabolic effects of the thyroid and adrenal glands.
Jefferys
D E
DE
Baker Medical Research Institute, Melbourne, Australia.
Funder
J W
JW
D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D016314:Ethylketocyclazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*; D013974:Thyroxine / Q000494:pharmacology
D016314:Ethylketocyclazocine; C012395:ketazocine; D003907:Dexamethasone; D013974:Thyroxine