Platelet aggregation inhibitors in a Bhutanese medicinal plant, shug chher.
The 90% methanol-soluble fraction of a Bhutanese medicinal plant, Shug Chher, exhibited inhibition of platelet aggregation induced by platelet activating factor. Bioassay-directed fractionation led to the isolation of four new labdane diterpenoids, 3 alpha, 15-dihydroxy-labda-8(17), 13E-diene (5), 3 alpha-hydroxy-labda-8(17), 13E-dien-15-oic acid (6), 3 alpha-hydroxy-labda-8(17), 12E, 14-trien-19-oic acid (7), and 3 alpha-acetoxyisocupressic acid (8) and four known diterpenoids, manool (1), 3 alpha-hydroxymanool (2), 3 alpha-hydroxy-12, 13E-biformene (3), and isocupressic acid (4). The structures of the new compounds were determined spectroscopically. Compounds 2, 3, and 5 inhibited platelet aggregation.
Kagawa
K
K
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Tokura
K
K
Uchida
K
K
Kakushi
H
H
Shike
T
T
Kikuchi
J
J
Nakai
H
H
Dorji
P
P
Subedi
L
L
D001631:Bhutan; D006801:Humans; D066298:In Vitro Techniques; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors