Comparison of flunixin, prednisolone, dimethyl sulfoxide, and a lazaroid (U74389F) for treating endotoxemic neonatal calves.
Saline (0.9% NaCl) solution, flunixin meglumine (1.1 mg/kg), prednisolone sodium succinate (1.1 mg/kg), U74389F (1.5 mg/kg), and dimethyl sulfoxide (0.5 g/kg) were each administered i.v. to 5 neonatal calves 15 minutes after the start of a 3-hour infusion of Escherichia coli lipopolysaccharide (LPS; 2 micrograms/kg/hr). Four additional calves were given a 3-hour i.v. infusion of saline solution alone. Only flunixin significantly suppressed eicosanoid production and mitigated clinical signs associated with endotoxemia. Prednisolone provided partial protection against LPS-induced hypotension and lacticemia. Pronounced hypoglycemia and lacticemia were observed in U74389F-treated calves; LPS-induced hypotension and hypoglycemia were marked in dimethyl sulfoxide-treated calves.
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Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
D000818:Animals; D000831:Animals, Newborn / Q000097:blood; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D003002:Clonixin / Q000031:analogs & derivatives / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D015777:Eicosanoids / Q000097:blood; D004731:Endotoxins; D005260:Female; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008070:Lipopolysaccharides; D008297:Male; D011239:Prednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D011281:Pregnatrienes / Q000627:therapeutic use*; D014115:Toxemia / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*
D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D015777:Eicosanoids; D004731:Endotoxins; D007773:Lactates; D008070:Lipopolysaccharides; D011281:Pregnatrienes; C074965:U 74389F; D019344:Lactic Acid; C014558:flunixin meglumine; D011239:Prednisolone; C021322:prednisolone hemisuccinate; D003002:Clonixin; D004121:Dimethyl Sulfoxide