Effect of systemic anaphylaxis on the hepatic drug-metabolizing system in rats.
Rats were immunized by intraperitoneal injection of ovalbumin emulsified with Freund incomplete adjuvant, and then the effect of an intravenous challenge with ovalbumin on hepatic drug-metabolizing enzyme activities was examined. The cytochrome P-450 content and ethylmorphine N-demethylase, benzphetamine N-demethylase, arylhydrocarbon hydroxylase and 7-ethoxycoumarin O-deethylase activities significantly decreased in rats treated with ovalbumin compared with control groups treated with saline, whereas there was no significant reduction in cytochrome b5, NADPH-cytochrome c reductase and NADH-cytochrome c reductase.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Ozaki
M
M
Takayanagi
Y
Y
Sasaki
K
K
D000707:Anaphylaxis / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D006899:Mixed Function Oxygenases / Q000276:immunology / Q000378:metabolism; D010047:Ovalbumin / Q000276:immunology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D004364:Pharmaceutical Preparations; D010047:Ovalbumin; D006899:Mixed Function Oxygenases