title: Free radicals and muscle damage.
abstract: Muscle tissue is unique in its requirement and ability to undertake very rapid and co-ordinated changes in energy supply and oxygen flux during contraction. Several studies have suggested that this renders the tissue particularly prone to oxygen radical-mediated damage. Free radicals have been postulated to play a role in muscle damage induced by different forms of exercise and in various pathological disorders, such as the muscular dystrophies, malignant hyperthermia and alcoholic myopathy. However, conclusive evidence for a fundamental role for free radicals and protective effect of antioxidants remains elusive in all these situations and much further work on the relevant pathogenetic mechanisms is still required.
authors.affiliation: Department of Medicine, University of Liverpool, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: O'Farrell
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D015444:Exercise / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D009132:Muscles / Q000378:metabolism*; D009135:Muscular Diseases / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats
chemical_list: D000975:Antioxidants; D005609:Free Radicals