The inhibitory effect of SA3443, a novel cyclic disulfide compound, on alpha-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats.
1. We investigated the effect of SA3443, a novel cyclic disulfide compound, on alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis in rats. 2. SA3443 given orally at doses of 100 or 300 mg/kg, three times at 4h intervals, dose-dependently suppressed the elevation of serum total bilirubin, alkaline phosphatase activity and transaminase activities induced by administration of ANIT (80 mg/kg) 3h before the second dosages of SA3443. 3. SA3443 also significantly inhibited the reduction of bile flow in the ANIT-treated rats. 4. These findings indicated that SA3443 had a markedly inhibitory effect on ANIT-induced intrahepatic cholestasis in rats.
Tanaka
M
M
Central Research Laboratories, Santen Pharmaceutical Co. Ltd, Osaka, Japan.
Nakata
K
K
Mita
S
S
D015058:1-Naphthylisothiocyanate / Q000037:antagonists & inhibitors*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001392:Azocines / Q000008:administration & dosage / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced / Q000517:prevention & control*; D004220:Disulfides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000276:Adjuvants, Immunologic; D001392:Azocines; D004220:Disulfides; C069788:SA 3443; D015058:1-Naphthylisothiocyanate; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin