title: CD30 (Ki-1) positive anaplastic large cell lymphomas in individuals infected with the human immunodeficiency virus.
abstract: BACKGROUND
  CD30 (Ki-1) positive anaplastic large cell lymphoma (ALCL) has been only rarely described in HIV-positive patients.
  
  
  METHODS
  The clinicopathologic features of eight ALCLs occurring in four AIDS and four HIV-positive patients were investigated. The phenotype of each neoplasm was determined by immunohistochemical methods. In three cases fresh tissue was available for molecular analysis.
  
  
  RESULTS
  The ALCLs are a clinically heterogeneous group of T (4), B (1) and indeterminate (3) cell malignant lymphomas which presented in the skin (4), liver (1), lung (1), nasal cavity (1; also with bone marrow involvement) and peritoneal fluid (1). While most of the patients had aggressive disease, dying in a median of three months, two patients had either localized or regressing skin lesions. Molecular studies showed that two ALCLs, one of B cell and one of indeterminate cell lineage, contained clonal Epstein-Barr virus sequences. None of the ALCLs examined contained evidence of HTLV-1 or HIV integration nor did they exhibit c-myc or bcl-2 proto-oncogene rearrangements. No mutations or deletions of the p53 tumor suppressor gene were identified in the three cases studied.
  
  
  CONCLUSIONS
  HIV-related ALCL represents a clinically heterogeneous group of T cell, B cell and null cell malignant lymphomas, distinct from the previously described categories of AIDS-associated NHL, that may expand the spectrum of lymphoid neoplasms associated with HIV-infection. Identification and investigation of other cases of HIV-associated ALCL is important to determine the nature of the relationship between HIV infection and the development of ALCL.
authors.affiliation: Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
authors.forename: A
authors.initials: A
authors.lastname: Chadburn
authors.forename: E
authors.initials: E
authors.lastname: Cesarman
authors.forename: J
authors.initials: J
authors.lastname: Jagirdar
authors.forename: M
authors.initials: M
authors.lastname: Subar
authors.forename: R N
authors.initials: RN
authors.lastname: Mir
authors.forename: D M
authors.initials: DM
authors.lastname: Knowles
mesh_terms: D000328:Adult; D016147:Genes, Tumor Suppressor; D016259:Genes, myc; D006679:HIV Seropositivity / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D016483:Lymphoma, AIDS-Related / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes