[Types of anticellular structure antisera in scleroderma patients].
The sera of 338 scleroderma patients were cytologically examined with indirect immunofluorescence method. The sera were classified according to the cellular structure, to which they were against respectively. Among these sera, six main types of cellular structure antiserum were found: antikinetochore, antinucleolus, antichromatin, antiheterochromatin, antichromosome and anticentrosome. Some of these main types can further be subtyped with respect to the substructure or the chemical components (antigens) of a particular cellular structure. These types of antiserum may possibly be correlated with the clinical signs of scleroderma patients. For exploring the possibility to use for diagnosis.
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Shanghai Institute of Cellbiology, Chinese Academy of Sciences.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D007106:Immune Sera