Concentrations of nucleotides, nucleosides, purine bases and urate in cerebrospinal fluid of children with meningitis.
The release of agents mediating inflammation in meningitis may bring about neuronal hypoxia, under which circumstances ATP concentrations decrease and its degradation products increase and are released into the cerebrospinal fluid. In this study of alterations in neuronal energy metabolism in meningitis, AMP, IMP, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine and urate were determined by high performance liquid chromatography in the cerebrospinal fluid of 54 children aged between 1 month and 13 years suffering from meningitis (25 viral, 24 bacterial and 5 tuberculous cases) and 63 controls. Compared to the controls, patients with viral meningitis exhibited high concentrations of IMP, adenosine, guanosine, adenine, guanine and xanthine; patients with bacterial meningitis exhibited high concentrations of IMP, inosine, guanosine, adenosine, hypoxanthine, xanthine and urate; and patients with tuberculous meningitis exhibited high concentrations of AMP, guanosine, xanthine and urate. Viral and bacterial cases did not differ significantly for any of the metabolites studied. AMP and urate concentrations were significantly higher in patients with tuberculous cases compared with viral or bacterial meningitis cases.
Rodríguez-Núñez
A
A
Department of Paediatrics, Hospital General de Galicia, Clínico Universitario, Santiago de Compostela, Spain.
Camiña
F
F
Lojo
S
S
Rodríguez-Segade
S
S
Castro-Gago
M
M
D000249:Adenosine Monophosphate / Q000134:cerebrospinal fluid; D000255:Adenosine Triphosphate / Q000134:cerebrospinal fluid; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000134:cerebrospinal fluid; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid; D009705:Nucleosides / Q000134:cerebrospinal fluid*; D009711:Nucleotides / Q000134:cerebrospinal fluid*; D014390:Tuberculosis, Meningeal / Q000134:cerebrospinal fluid; D014527:Uric Acid / Q000134:cerebrospinal fluid*; D019820:Xanthine; D014970:Xanthines / Q000134:cerebrospinal fluid
D007042:Hypoxanthines; D009705:Nucleosides; D009711:Nucleotides; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate