title: Correlation between susceptibility to demyelination and interferon-gamma induction of major histocompatibility complex class II antigens on murine cerebrovascular endothelial cells.
abstract: The induction of major histocompatibility complex (MHC) Class II expression was studied on cerebrovascular endothelial cells (CVE) obtained from strains of mice that are resistant (BALB/c) and susceptible (SJL and CBA) to Theiler's virus-induced demyelination (TVID). Following 24 h treatment with interferon (IFN)-gamma, MHC Class II was induced on CVE derived from susceptible but not resistant strains of mice. However, IFN-gamma induced the expression of MHC Class II on late passages of BALB/c CVE. These results demonstrate a correlation between susceptibility to demyelination and the ability of IFN-gamma to induce the expression of MHC Class II on CVE. In susceptible strains of mice, the presence of activated, IFN-gamma-secreting T cells, in the vicinity of CVE would increase the antigen-presenting capabilities of CVE and result in increased T cell traffic into the central nervous system.
authors.affiliation: Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A & M University, College Station 77843-4458.
authors.forename: J
authors.initials: J
authors.lastname: Welsh
authors.forename: B
authors.initials: B
authors.lastname: Sapatino
authors.forename: B
authors.initials: B
authors.lastname: Rosenbaum
authors.forename: R
authors.initials: R
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Linthicum
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D001921:Brain / Q000098:blood supply*; D002478:Cells, Cultured; D003711:Demyelinating Diseases / Q000209:etiology*; D004730:Endothelium, Vascular / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000502:physiology; D017945:Theilovirus / Q000472:pathogenicity
chemical_list: D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma