[Flumazenil, a benzodiazepine antagonist, in endoscopic premedication].
Midazolam is the benzodiazepine recommended for anaesthesia induction when an early recovering is desirable. Flumazenil, which is also a hydrosoluble imidazobenzodiazepine, improves the safety of the forhere one because it immediately reduces the degree of sedation. With this purpose, this last drug has been studied in 25 patients who had been previously treated with Midazolam in order to carry out different endoscopic studies. The Flumazenil average dose used was 0.276 mg and the conscience recovering after its intravenous injection, evaluated by a simple oral numeric regression test, oscillated between 60 and 300 seconds with an X of 96 seconds. Once the study was finished, all patients were discharged from hospital after two-hour observation, except for one patient (4%) who suffered a complication and so was discharged after a twenty-four-hour control. No doubt the advent of a drug opposed to benzodiazepine receptors used in anaesthetic induction shows the possibility of a quick recovering and moreover. Quicker discharge from hospital.
Segal
E
E
Unidad de Gastroenterología, Hospital Durand, Buenos Aires, Argentina.
Etchepare
S
S
Balbachan
O
O
Broderson
C
C
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005442:Flumazenil / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008297:Male; D008874:Midazolam / Q000037:antagonists & inhibitors / Q000737:chemistry; D008875:Middle Aged; D011292:Premedication
D005442:Flumazenil; D008874:Midazolam
Experiencia con flumazenil, antagonista de las benzodiapezinas, en premedicación endoscópica.