title: Low-dose and high-dose mitomycin trabeculectomy as an initial surgery in primary open-angle glaucoma.
abstract: OBJECTIVE
  The purpose of the study is to determine the optimum regimen of intraoperative administration of mitomycin as an adjunct to trabeculectomy.
  
  
  METHODS
  Of 11 patients with primary open-angle glaucoma, 22 eyes that had not undergone any surgical intervention were included. In each patient, one eye was randomly allocated to a mitomycin 0.2-mg group and the fellow eye to a mitomycin 0.02-mg group. Mitomycin was applied for 5 minutes only once during trabeculectomy. The follow-up period was 6 to 17 months.
  
  
  RESULTS
  Eleven (100%) eyes in the 0.2-mg group and 7 (63.6%) in the 0.02-mg group achieved successful control of intraocular pressure with or without topical antiglaucoma medication. Transient hypotony maculopathy (18%) and cataract progression (18%) were noted in the 0.2-mg group exclusively. The incidence of other complications was similar between the two groups.
  
  
  CONCLUSIONS
  These data suggest that the most appropriate dose of mitomycin for primary surgery seems to be in between the two doses tested in the current study.
authors.affiliation: Department of Ophthalmology, Gifu University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitazawa
authors.forename: H
authors.initials: H
authors.lastname: Suemori-Matsushita
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Kawase
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D014130:Trabeculectomy
chemical_list: D016685:Mitomycin