title: Squamous-cell carcinoma arising in a non-irradiated child with recurrent respiratory papillomatosis.
abstract: We describe a patient with recurrent respiratory papillomatosis (RRP) associated with human papilloma virus (HPV), who developed a fatal squamous cell carcinoma of the lung. At the age of 1 year he presented with hoarseness, dyspnoea and inspiratory stridor but the diagnosis of RRP was made only 1 year later. At the age of 4 years he was tracheostomized because of upper airway obstruction. In spite of multiple surgical excisions and topic treatment with 5-fluorouracil the papillomata extended to the lung parenchyma. At the age of 16 years he developed a squamous-cell carcinoma of the lung and died 4 months later. Transformation to pulmonary carcinoma is a rare complication in non-irradiated patients with lung papillomatosis. We found only 11 similar cases in the literature.
authors.affiliation: Intensive Care Unit, University Children's Hospital, Zurich, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Simma
authors.forename: R
authors.initials: R
authors.lastname: Burger
authors.forename: J
authors.initials: J
authors.lastname: Uehlinger
authors.forename: D
authors.initials: D
authors.lastname: Ghelfi
authors.forename: E
authors.initials: E
authors.lastname: Hof
authors.forename: P
authors.initials: P
authors.lastname: Dangel
authors.forename: J
authors.initials: J
authors.lastname: Briner
authors.forename: S
authors.initials: S
authors.lastname: Fanconi
mesh_terms: D000293:Adolescent; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000382:microbiology / Q000473:pathology*; D010212:Papilloma / Q000382:microbiology / Q000473:pathology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology; D012142:Respiratory Tract Neoplasms / Q000382:microbiology / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology