title: Conserved synteny between pig chromosome 8 and human chromosome 4 but rearranged and distorted linkage maps.
abstract: The porcine genes encoding interleukin 2, alcohol dehydrogenase (class I) gamma polypeptide, and osteopontin were mapped to chromosome 8 by linkage analysis. Together with previous assignments to this chromosome (the albumin, platelet-derived growth factor receptor A, and fibrinogen genes), an extensive syntenic homology with human chromosome 4 was discovered. Loci from about three-quarters of the q arm of human chromosome 4 are on pig chromosome 8. However, the linear order of the markers is not identical in the two species, and there are several examples of interspecific differences in the recombination fractions between adjacent markers. The conserved synteny between man and the pig gives strong support to a previous suggestion that a synteny group present in the ancestor of mammalian species has been retained on human chromosome 4q. Since loci from this synteny group are found on two cattle chromosomes, the bovine rearrangement must have occurred after the split of Suidae and Bovidae within Artiodactyla.
authors.affiliation: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.
authors.forename: H
authors.initials: H
authors.lastname: Ellegren
authors.forename: M
authors.initials: M
authors.lastname: Fredholm
authors.forename: I
authors.initials: I
authors.lastname: Edfors-Lilja
authors.forename: A K
authors.initials: AK
authors.lastname: Winterø
authors.forename: L
authors.initials: L
authors.lastname: Andersson
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D017124:Conserved Sequence; D004247:DNA / Q000235:genetics; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D053495:Osteopontin; D010375:Pedigree; D012091:Repetitive Sequences, Nucleic Acid; D012795:Sialoglycoproteins / Q000235:genetics; D013552:Swine / Q000235:genetics*
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers; D007376:Interleukin-2; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin; D004247:DNA; D000426:Alcohol Dehydrogenase