title: Low-grade lymphoma following intensive treatment of large-cell lymphoma.
abstract: Progression of a low-grade non-Hodgkin's lymphoma into a more aggressive histologic pattern is a well-described phenomenon. The converse phenomenon, often called downgrading, is much less frequent. We report 2 patients in whom relapse with an indolent lymphoma was noted after chemotherapy for higher-grade disease. Other previously reported cases are reviewed. The implications for appropriate management and pathogenesis are discussed.
authors.affiliation: Hematology Service, University Hospital, Federal University of Rio de Janeiro, Brazil.
authors.forename: N
authors.initials: N
authors.lastname: Spector
authors.forename: W
authors.initials: W
authors.lastname: Pulcheri
authors.forename: M
authors.initials: M
authors.lastname: Nucci
authors.forename: J C
authors.initials: JC
authors.lastname: de Morais
authors.forename: H P
authors.initials: HP
authors.lastname: de Oliveira
mesh_terms: D000328:Adult; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000628:therapy; D008297:Male; D012074:Remission Induction