Normotensive blacks have heightened sympathetic response to cold pressor test.
The purpose of this study was to compare sympathetic nerve activity responses to the cold pressor test in black and white normotensive subjects. We recorded muscle sympathetic nerve activity (microneurography of the peroneal nerve), arterial blood pressure, and heart rate in 9 normotensive American blacks (24 +/- 2 years, mean +/- SEM) and 10 normotensive American whites (28 +/- 2 years) at rest and during hand immersion in ice water (cold pressor test). Body weight was not different in the two groups (72.4 +/- 3.7 versus 74.1 +/- 3.8 kg, black versus white subjects). During supine rest, mean arterial pressure (92 +/- 2 versus 93 +/- 3 mm Hg, black versus white), heart rate (66 +/- 4 versus 62 +/- 3 beats per minute, black versus white), and muscle sympathetic nerve burst frequency (12 +/- 2 versus 17 +/- 3 bursts per minute, black versus white) were not different in the two groups. During the cold pressor test, mean arterial pressure, heart rate, and muscle sympathetic nerve activity increased from supine rest in both groups. The magnitudes of increases in mean arterial pressure and total minute muscle sympathetic nerve activity were significantly greater in blacks than whites (33.5 +/- 3 versus 22.4 +/- 3 mm Hg and 416 +/- 24% versus 243 +/- 31% of control, respectively, black versus white, P < .05). The increases in heart rate were most significantly different for the two groups. These data suggest that the enhanced pressor response to cold stress observed in normotensive blacks is attributable to greater increases in peripheral sympathetic nerve activity.(ABSTRACT TRUNCATED AT 250 WORDS)
Calhoun
D A
DA
Department of Medicine, University of Alabama at Birmingham 35294.
Mutinga
M L
ML
Collins
A S
AS
Wyss
J M
JM
Oparil
S
S
D000328:Adult; D000704:Analysis of Variance; D044383:Black People; D001794:Blood Pressure; D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D009132:Muscles / Q000294:innervation; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013312:Stress, Physiological / Q000503:physiopathology*; D016683:Supine Position; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D044465:White People
D012964:Sodium; D011188:Potassium