title: Soluble Fc gamma receptors.
abstract: Soluble Fc gamma receptors have been identified in biological fluids of mice and humans. They are produced either by alternative splicing of the exon encoding the transmembrane region of the receptor (Fc gamma RII) or by proteolytic cleavage at the cell membrane (Fc gamma RII and Fc gamma RIII). They inhibit B cell proliferation and immunoglobulin production. Their concentrations in plasma seem to be modified during the development of certain diseases, as for instance in multiple myeloma, where plasma concentrations of soluble Fc gamma RIII are correlated with the stage of the disease.
authors.affiliation: INSERM Unité 255, Institut Curie, France.
authors.forename: W H
authors.initials: WH
authors.lastname: Fridman
authors.forename: J L
authors.initials: JL
authors.lastname: Teillaud
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
authors.forename: C
authors.initials: C
authors.lastname: Teillaud
authors.forename: A
authors.initials: A
authors.lastname: Astier
authors.forename: E
authors.initials: E
authors.lastname: Tartour
authors.forename: J
authors.initials: J
authors.lastname: Galon
authors.forename: C
authors.initials: C
authors.lastname: Mathiot
authors.forename: C
authors.initials: C
authors.lastname: Sautès
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D017452:Receptors, IgG / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D012995:Solubility
chemical_list: D017452:Receptors, IgG