title: Clomipramine versus placebo in the treatment of premature ejaculation: a pilot study.
abstract: This study evaluated clomipramine as a possible treatment for premature ejaculation. Twenty patients with premature ejaculation were randomly allocated to treatment with clomipramine or placebo in a double-blind study. Average estimated time to ejaculation after vaginal penetration increased to 6.1 minutes on 25 mg. of clomipramine and to 8.4 minutes on 50 mg. of clomipramine. These estimated times were significantly different from estimated time to ejaculation while on placebo. These findings suggest that low dose clomipramine may be useful in the treatment of premature ejaculation.
authors.affiliation: Department of Psychiatry, MetroHealth Medical Center, Cleveland, Ohio.
authors.forename: R T
authors.initials: RT
authors.lastname: Segraves
authors.forename: A
authors.initials: A
authors.lastname: Saran
authors.forename: K
authors.initials: K
authors.lastname: Segraves
authors.forename: E
authors.initials: E
authors.lastname: Maguire
mesh_terms: D000328:Adult; D002997:Clomipramine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010919:Placebos; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D002997:Clomipramine