title: Thymectomy in over 50 years-old patients with myasthenia gravis: long and short-term results in 21 patients.
abstract: Thymectomy is considered to be an important method for the treatment of myasthenia gravis in older patients when the improvement cannot be achieved with the use certain drugs such as anticholinesterasic, corticosteroids and immunosuppressive agents. In our series of 281 thymectomized patients, 13 were male and 8 female, varying their age between 50 and 73 years. The duration of the disease prior to the thymectomy varied between 30 days and 15 years; in 12 of them (57%) it lasted already 2 years. Eleven patients had the severe and eight the moderate clinical form of the disease. Nine patients were treated with corticosteroids before submitted to thymectomy. In 11 patients the histopathological changes in the thymus were evaluated: eight had thymomas, one atrophic changes, one lipomatosis and one a normal thymus. The short-term follow-up revealed important improvement in 12 patients, slight improvement in four and worsening in two; two patients died. It is concluded that thymectomy may be indicated in older patients when their condition worsens in spite of the use of corticosteroids and immunosuppressive agents, in the presence of serological markers or computerized tomography image indicating thymoma, and intolerance for corticosteroids.
authors.affiliation: Department of Neurology, University of São Paulo Medical School.
authors.forename: J L
authors.initials: JL
authors.lastname: de Assis
authors.forename: P E
authors.initials: PE
authors.lastname: Marchiori
authors.forename: A A
authors.initials: AA
authors.lastname: Zambon
authors.forename: M
authors.initials: M
authors.lastname: Scaff
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000601:surgery*; D012189:Retrospective Studies; D013934:Thymectomy; D013950:Thymus Gland / Q000473:pathology; D013997:Time Factors