Changes of 31P-MR spectroscopy in experimental tumors following radiotherapy combined with 5-fluorouracil compound (UFT).
The energy metabolism of FM3A tumors in C3H mice following radiotherapy (20 Gy or 40 Gy), 5-fluorouracil compound (UFT) chemotherapy or radiotherapy (20 Gy) combined with UFT was investigated by in vivo 31P-MR spectroscopy on day 2 after treatment. The effects were compared with the growth curves of the tumors and with the cytokinetic and histological changes in the tumors on day 5 after treatment. The combined group (20 Gy+UFT) showed growth curves similar to the 40 Gy group. Cytokinetic and histological changes of the combined group were also similar to those of the 40 Gy group, suggesting supra-additive effect of UFT. 31P-MR spectra of the combined group were similar to those of the 40 Gy group which were characterized by increase of intracellular pH(pHi), decrease of Pi/beta-NTP and of PME/total phosphorus-signal ratios. Spectra of the UFT group and the 20 Gy group, on the contrary, showed decrease of pHi, increase of Pi/beta-NTP and of PME/total phosphorus-signal ratios. Changes detected by 31P-MR spectroscopy on day 2 were considered to reflect early metabolic events which were correlated to the growth curve, cytokinetic and histological alterations observed on day 5 after treatment.
Ohkubo
M
M
Department of Radiological Technology, College of Biomedical Technology, Niigata University.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D000818:Animals; D002455:Cell Division; D003131:Combined Modality Therapy; D005434:Flow Cytometry; D005472:Fluorouracil / Q000627:therapeutic use*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation
D005472:Fluorouracil