title: Synthesis and biological properties of 5-hydroxy-methylpyrimidines.
abstract: Reduction of 4-arylamine-6-methyl-2-phenyl-5-pyrimidine carboxylic acid and its ethyl esters as well as 5,7-dihydrofuro (3,4-d)-pyrimidines resulted in obtaining some 4-arylamine-6-methyl-2-phenyl-5-hydroxymethylpyrimidines exhibiting strong immunomodulatory and cytostatic properties.
authors.affiliation: Organic Chemistry Department, Medical Academy, Wrocław, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Cieplik
authors.forename: Z
authors.initials: Z
authors.lastname: Machoń
authors.forename: M
authors.initials: M
authors.lastname: Zimecki
authors.forename: Z
authors.initials: Z
authors.lastname: Wieczorek
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D011743:Pyrimidines