The interaction between central cholinergic and peripheral beta-adrenergic systems on radial maze performance in rats.
The interaction between cholinergic and beta-adrenergic systems on radial arm maze performance was investigated. Scopolamine significantly disrupted radial maze performance. Although neither propranolol (a centrally and peripherally acting beta-antagonist), nor atenolol (a peripherally acting beta 1-antagonist) affected the maze performance, both antagonists significantly augmented the scopolamine disruption. These results suggest the importance of the interaction between central cholinergic and peripheral beta-adrenergic systems on radial maze performance.
Ohta
H
H
Section of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.
Matsumoto
K
K
Watanabe
H
H
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D001262:Atenolol; D011433:Propranolol; D012601:Scopolamine; D000109:Acetylcholine