Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.
In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrotoxicity were observed.
Siegers
C P
CP
Institutes of Toxicology, Medical University of Lübeck, FRG.
Siemers
J
J
Baretton
G
G
D019813:1,2-Dimethylhydrazine; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology*; D000504:Aloe; D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology*; D002400:Cathartics / Q000633:toxicity*; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D004127:Dimethylhydrazines; D004642:Emodin / Q000031:analogs & derivatives* / Q000633:toxicity; D015994:Incidence; D008297:Male; D051379:Mice; D010946:Plants, Medicinal; D011897:Random Allocation; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D002273:Carcinogens; D002400:Cathartics; D004127:Dimethylhydrazines; D000081226:Sennosides; D012676:Senna Extract; D019813:1,2-Dimethylhydrazine; D004642:Emodin; C006457:alloin