Self-association of violamycin (VBI).
Violamycin (VBI) self-associates in aqueous solution at concentration greater than 7 x 10(-5) M. We report in this paper visible spectrophotometric and kinetic experiments that characterize this self-association. We started from a simple dimerization model supported by our experimental data, and we used different methods described in literature for the computation of the dimeric extinction coefficient epsilon d at various wavelengths and the dimerization constant Kd = 9300 M-1.
Oncescu
T
T
Department of Physical Chemistry, Faculty of Chemistry, University of Bucharest, Romania.
Iliescu
I
I
De Mayer
L
L
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D007700:Kinetics; D013057:Spectrum Analysis; D013696:Temperature
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C010806:violamycins