title: Efficacy of recombinant bovine somatotrophin in the treatment of fat cow syndrome.
abstract: Recombinant bovine somatotrophin was used in addition to conventional therapy to treat a sample of post-calving cows in a herd suffering a high incidence of fat cow syndrome. Somatotrophin was also given to cows before they calved. There were no significant differences between the treated and untreated groups in the plasma concentrations of glucose, beta-hydroxybutyrate, albumin, total protein or calcium. Significant decreases in mean plasma urea concentration were observed in the pre-calving cows seven and 10 days after treatment with somatotrophin, and a significant decrease in mean plasma urea concentration was also recorded in post-calving cows with the fat cow syndrome. There was no evidence that somatotrophin, with its many potent actions in cows with acetonemia, exacerbated clinical ketosis. The authors' subjective clinical impression was that somatotrophin was helpful in the treatment of cows with the fat cow syndrome.
authors.affiliation: Department of Large Animal Medicine and Surgery, Royal Veterinary College, Hatfield, Hertfordshire.
authors.forename: I
authors.initials: I
authors.lastname: Maisey
authors.forename: A H
authors.initials: AH
authors.lastname: Andrews
authors.forename: R A
authors.initials: RA
authors.lastname: Laven
mesh_terms: D020155:3-Hydroxybutyric Acid; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005234:Fatty Liver / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use*; D006885:Hydroxybutyrates / Q000097:blood; D011994:Recombinant Proteins / Q000627:therapeutic use; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D006885:Hydroxybutyrates; D011994:Recombinant Proteins; D014508:Urea; D013006:Growth Hormone; D020155:3-Hydroxybutyric Acid