title: Safety and immunogenicity of live attenuated hepatitis A virus vaccine (H2 strain) in humans.
abstract: A study was made in Neijiang City, Sichuan Province to observe the safety and immunogenicity of a live attenuated hepatitis A virus (HAV) vaccine (H2 strain). 3,031 children, aged 6 to 9 years, were injected subcutaneously with 10(6.0) TCID50, 10(5.5) TCID50, and 10(5.0) TCID50 of HAV vaccine; the seroconversion rate and antibody GMT were 97.52%-90.68%, GMT = 1:5.19 +/- 1.90-1:3.36 +/- 1.94; 84.75%-76.27%, GMT = 1:4.29 +/- 1.96-1:2.0 +/- 2.67; 53.23%-51.61%, GMT = 1:2.57 +/- 1.89-1:1.68 +/- 1.41 respectively after 4 weeks to 12 months of inoculation. Forty-eight children in the control group were anti-HAV negative at 4, 8, and 12 weeks; 21 children in the oral group were not antibody positive 4 and 8 weeks after oral administration of the vaccine. The stool specimens of 3 of the 14 vaccinated children were HAA positive. The results suggest that the live attenuated HAV vaccine (H2 strain) is of good immunogenicity and safety.
authors.affiliation: Health and Anti-Epidemic Station of Sichuan Province, Chengdu.
authors.forename: L A
authors.initials: LA
authors.lastname: Ran
authors.forename: D Z
authors.initials: DZ
authors.lastname: Wang
authors.forename: Q Y
authors.initials: QY
authors.lastname: Duan
authors.forename: T Y
authors.initials: TY
authors.lastname: Yan
authors.forename: Q L
authors.initials: QL
authors.lastname: Liu
authors.forename: Y G
authors.initials: YG
authors.lastname: Luo
authors.forename: D Z
authors.initials: DZ
authors.lastname: Yang
authors.forename: D F
authors.initials: DF
authors.lastname: Yang
authors.forename: Z
authors.initials: Z
authors.lastname: Xiao
authors.forename: Q J
authors.initials: QJ
authors.lastname: Xie
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D002648:Child; D006506:Hepatitis A / Q000517:prevention & control*; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies / Q000097:blood; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D014613:Vaccines, Attenuated / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D014613:Vaccines, Attenuated; D014761:Viral Hepatitis Vaccines; D000410:Alanine Transaminase