A comment on the absence of calcium regulation of human thioredoxin reductase.
It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.
Oblong
J E
JE
Arizona Cancer Center, Tucson 85715.
Powis
G
G
D002118:Calcium / Q000378:metabolism*; D006801:Humans; D010920:Placenta / Q000201:enzymology; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism*
D013880:Thioredoxin-Disulfide Reductase; D002118:Calcium