title: Monoclonal antibodies for the induction of transplantation tolerance.
abstract: Non-lytic antibodies to CD4 and certain other T cell adhesion receptors can guide the immune system to become tolerant to foreign antigens, and to regain tolerance in autoimmunity. Tolerance is maintained lifelong through the action of regulatory T cells that in turn can influence naive T cells to acquire the same regulatory properties. A fuller understanding of the molecular basis of infectious tolerance could lead to the design of better immunosuppressive protocols.
authors.affiliation: Department of Pathology, University of Cambridge, UK.
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
authors.forename: S
authors.initials: S
authors.lastname: Cobbold
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D000911:Antibodies, Monoclonal