Viscoelasticity of BLM from choline plasmalogen, alkylacyl- and diacyl-glycerophosphocholines.
Mechanical characteristics of bilayer lipid membranes (BLM) composed of alkenylacyl-, alkylacyl-, and diacyl-glycerophosphocholines were studied by measuring modulus of elasticity in the direction normal to BLM plane, E perpendicular, and coefficient of dynamic viscosity eta. Alkenylacyl-glycerophosphocholine (choline plasmalogen) BLM typically show larger values of E perpendicular and eta as compared to their analogs, suggesting a tighter packing of their hydrophobic regions. Increasing cholesterol concentrations are associated with monotonically increasing values of parameters E perpendicular and eta of plasmalogen BLM, whereas a nonmonotonic dependence of these parameters with a maximum around c = 66 mol% cholesterol is typical for the diacyl analog POPC. This may be due to the formation of cholesterol clusters at c > 66 mol%.
Hianik
T
T
Department of Biophysics, Faculty of Mathematics and Physics, Comenius University, Bratislava, Slovakia.
Dlugopolský
J
J
Masaryková
D
D
Paltauf
F
F
Hermetter
A
A
D002784:Cholesterol; D004548:Elasticity; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D010713:Phosphatidylcholines; D010955:Plasmalogens; D013329:Structure-Activity Relationship; D014783:Viscosity
D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010955:Plasmalogens; C032459:choline plasmalogens; D002784:Cholesterol