The effect of 2,4-dinitrophenol on the metabolic rate of bobwhite quail.
Bobwhite quail were exposed to 2,4-dinitrophenol (DNP) in a respirometer designed to continuously monitor exchange of O2 and CO2, from which metabolic rates (MR) were estimated. After 14-16 days of acclimation to the system (temperature 22 degrees C, light cycle 8L:14D), hens received feed amended with 0, 625, or 1250 ppm DNP ad libitum for 8 days, followed by 2-5 days of feed containing no DNP. The 625 ppm treatment produced dark-period MR 31-41% higher than corresponding control values, and light-period MR 23-32% higher than controls. The 1250 ppm treatment produced dark-period MR 48-77% higher than control values, and light-period MR 41-67% higher than controls. Over the 8 days of testing, the 625 ppm treatment hens expended 32% more energy than the control hens. Hens consuming 1250 ppm feed expended 60% more energy than control hens and lost most of their body fat. In general, the risk of being unable to meet energy demands for survival or reproduction would probably be substantially increased by the observed elevation in MR.
Dominguez
S E
SE
U.S. EPA Environmental Research Laboratory, Corvallis, Oregon 97333.
Menkel
J L
JL
Fairbrother
A
A
Williams
B A
BA
Tanner
R W
RW
D019297:2,4-Dinitrophenol; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004140:Dinitrophenols / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D011784:Quail / Q000378:metabolism*; D014475:Uncoupling Agents / Q000633:toxicity*
D004140:Dinitrophenols; D014475:Uncoupling Agents; D019297:2,4-Dinitrophenol