title: Hippocampal mossy fiber changes in mice transgenic for the human copper-zinc superoxide dismutase gene.
abstract: The copper-zinc superoxide dismutase (SOD-1) gene, located on chromosome 21 and triplicated in Down's syndrome (DS), is suspected to be involved in the neuropathology observed in Alzheimer's disease (AD), DS and physiological aging. In order to explore the effect of an overproduction of SOD-1 in the mouse hippocampus, we investigated the Timm-stained mossy fiber (MF) innervation in the hippocampus of transgenic mice for the human SOD-1 gene (hSOD-1 mice). The results showed a decrease of the MF projection area in the hSOD-1 mice overexpressing the SOD-1 protein. These findings suggest that free radicals could play a role in this particular synaptic loss.
authors.affiliation: URA 1294 CNRS, UFR Biomédicale des Saints Pères, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Barkats
authors.forename: J Y
authors.initials: JY
authors.lastname: Bertholet
authors.forename: P
authors.initials: P
authors.lastname: Venault
authors.forename: I
authors.initials: I
authors.lastname: Ceballos-Picot
authors.forename: A
authors.initials: A
authors.lastname: Nicole
authors.forename: J
authors.initials: J
authors.lastname: Phillips
authors.forename: R
authors.initials: R
authors.lastname: Moutier
authors.forename: P
authors.initials: P
authors.lastname: Roubertoux
authors.forename: P M
authors.initials: PM
authors.lastname: Sinet
authors.forename: C
authors.initials: C
authors.lastname: Cohen-Salmon
mesh_terms: D000818:Animals; D001369:Axons / Q000201:enzymology; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006624:Hippocampus / Q000033:anatomy & histology / Q000166:cytology / Q000201:enzymology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic; D009412:Nerve Fibers / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D005609:Free Radicals; D013482:Superoxide Dismutase