title: Brain-derived neurotrophic factor expression after long-term potentiation.
abstract: Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.
authors.affiliation: Department of Pharmacology, University of Auckland Medical School, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Dragunow
authors.forename: E
authors.initials: E
authors.lastname: Beilharz
authors.forename: B
authors.initials: B
authors.lastname: Mason
authors.forename: P
authors.initials: P
authors.lastname: Lawlor
authors.forename: W
authors.initials: W
authors.lastname: Abraham
authors.forename: P
authors.initials: P
authors.lastname: Gluckman
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D017403:In Situ Hybridization; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016291:Dizocilpine Maleate