Fluctuations in elastase of cervical mucus and clinical efficacy of cefodizime in obstetric and gynecologic infections.
Clinical efficacy of cefodizime (CDZM) in obstetric and gynecologic infections and in their prevention, and fluctuations in cervical mucus elastase in gynecologic infections and during pregnancy were studied, and the following results were obtained: 1. Cervical mucus elastase showed high values of > or = 5,001 micrograms/L in 68.2% of non-pregnant patients and in 25.9% of pregnant patients (gestational age of 24-42 weeks). Patients with concomitant chorioamnionitis showed a significantly higher rate of elastase elevation than those without this complication (63.2% vs. 25.9%, P < 0.005). 2. Cervical mucus elastase in uterine and pelvic infections showed high values before administration of CDZM but tended to decline with the progress of cure (15/19 cases, 78.9%). 3. The efficacy rate of 2-4 g/day of CDZM drip infusion against infections was 53/56 (94.6%) while the bacterial eradication rate was 36/38 (94.7%). The efficacy rate of 2 g/day of CDZM drip infusion for the prevention of postoperative infections was 429/431 (99.8%). Diarrhea occurred in 3/489 (0.6%) as subjective and objective side effects. Slight rises in GOT and GPT were noted in 13/486 (2.7%) as abnormal laboratory values. These results suggested the usefulness of CDZM in the obstetric and gynecologic fields.
Chimura
T
T
Department of Obstetrics and Gynecology, School of Medicine, Yamagata University.
Hirayama
T
T
D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002582:Cervix Mucus / Q000201:enzymology*; D004341:Drug Evaluation; D004716:Endometritis / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006801:Humans; D010196:Pancreatic Elastase / Q000032:analysis*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011292:Premedication; D002575:Uterine Cervicitis / Q000188:drug therapy* / Q000517:prevention & control
D010196:Pancreatic Elastase; D002439:Cefotaxime; C033356:cefodizime