[Anti-implantation action of nylestriol and its effect on uterine cytosol estrogen and progesterone receptor in rabbits].
The anti-implantation action of nylestriol in rabbit was studied. The changes of uterine cytosol estrogen and progesterone receptor (ER and PR) were analysed with the dextran-coated charcoal method. Plasma progesterone level of early pregnant rabbits was measured by radioimmunoassay. The results showed that oral nylestriol could obviously prevent the early pregnancy of rabbit by anti-implantation of blastocyst. The content of ER decreased in the nylestriol group (P < 0.01). The content of PR in nylestriol group was lower than that of the control group (P < 0.05). No significant difference of plasma progesterone level was noted between the control and treatment groups. These results suggest that there is close relationship between the anti-implantation effect of nylestriol and the decreased content of cytosol ER and PR during the pre-implantation period.
Xie
W
W
Ziheng
Q
Q
Lei
G
G
Qiu
D
D
Han
S
S
Han
Z
Z
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D011247:Pregnancy; D011800:Quinestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits; D011959:Receptors, Estradiol / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; C010722:nylestriol; D011800:Quinestrol