[The mutagenic effect of plasmid DNA pUC19 and its derivatives].
For a better understanding of the mechanism of foreign DNA mutagenesis, it is essential to study the validity of the changing DNA structure for manifestation of its mutagenic action on Drosophila melanogaster (method Basc). The testing of three different kinds of plasmid DNA has been carried out. The injections of only plasmid DNA pUC18 lead to a significant increase in the X-linked recessive lethal frequency. It is important to check mutagenicity of every new recombinant DNA.
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D000818:Animals; D003433:Crosses, Genetic; D004269:DNA, Bacterial / Q000235:genetics*; D004270:DNA, Circular / Q000235:genetics; D004331:Drosophila melanogaster; D005260:Female; D005804:Genes, Lethal / Q000235:genetics; D015750:Genes, gag / Q000235:genetics; D015751:Genes, pol / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D008297:Male; D016296:Mutagenesis / Q000235:genetics*; D010957:Plasmids / Q000235:genetics*; D014960:X Chromosome
D004269:DNA, Bacterial; D004270:DNA, Circular
Mutagennyĭ éffekt plazmidnykh DNK pUC19 i ee proizvodnykh.