Immunological relationships during primary infection with Heligmosomoides polygyrus. Regulation of fast response phenotype by H-2 and non-H-2 genes.
The inheritance of response phenotype to Heligmosomoides polygyrus was investigated in F1 hybrid progeny of fast and slow responder mouse strains. The fast responses of SJL(H-2s) and SWR(H-2q) mice were mediated by dominant genes complementing each other in F1 hybrids which lost worms earlier and produced faster parasite-specific IgG1 antibody responses than either parent. However, the response of F1 hybrids from crosses of C57BL/10 (B10, H-2b) mice with either SJL or SWR differed from that of the parental strains and from each other: (B10 x SWR)F1 lost worms earlier than SWR whilst (B10 x SJL)F1 lost worms later than SJL mice. The F1 progeny of SJL mice with congenic strains B10.G (H-2q) and B10.S (H-2s) lost worms as quickly as SJL. Therefore, the response phenotype mediated by the genome of SJL mice was unaffected by H-2 heterozygosity (with H-2q) or homozygosity (H-2s) despite heterozygosity with B10 background genes, but was slowed significantly by heterozygosity with H-2b. All hybrids involving heterozygosity with B10, irrespective of MHC haplotype or background, failed to clear worms completely, in each case a proportion of mice harbouring residual worm burdens after loss of worms from parental strains.
Wahid
F N
FN
Department of Life Science, University of Nottingham, University Park.
Behnke
J M
JM
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation / Q000276:immunology; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D009351:Nematospiroides dubius / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D017206:Strongylida Infections / Q000276:immunology*; D013997:Time Factors
D000909:Antibodies, Helminth; D006183:H-2 Antigens; D007074:Immunoglobulin G