Synthesis of oligonucleotides carrying linker groups at 1'-position of sugar residues.
A novel 2'-deoxyuridine analogue carrying an aminobutyl linker at 1'-position of the sugar residue was synthesized and incorporated into oligonucleotides, then an anthraquinone derivative was attached to the amino group. The oligonucleotides carrying the linker groups were more resistant to nuclease P1 and venom phosphodiesterase than an unmodified oligonucleotide.
Ono
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Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Dan
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Matsuda
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D002241:Carbohydrates / Q000737:chemistry*; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D006868:Hydrolysis; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000737:chemistry; D012910:Snake Venoms / Q000201:enzymology
D002241:Carbohydrates; D009841:Oligonucleotides; D012910:Snake Venoms; D015719:Single-Strand Specific DNA and RNA Endonucleases; D010727:Phosphoric Diester Hydrolases; D003857:Deoxyuridine