title: Functional brain imaging: dipole localization and Laplacian methods.
abstract: The performance of two methods, used to localize brain activity from evoked potential fields measured on the scalp, was assessed in a tank model of the human head. This physical model contained a human skull encased in a polymer simulating the resistivity and geometry of brain and scalp. The dipole localization method mislocalized the positions of known dipole sources by several centimeters. The mislocalization was systematic. The dipoles were localized too deeply in the head. The Laplacian method yielded a field resembling the brain surface field (epicortical potential field) provided that the iso-potential contours of the scalp field closed within the measurement range. Clipping resulted in a serious mislocalization of the position of the peak of the epicortical potential field.
authors.affiliation: Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas 75235-8592.
authors.forename: R
authors.initials: R
authors.lastname: Srebro
authors.forename: R M
authors.initials: RM
authors.lastname: Oguz
authors.forename: K
authors.initials: K
authors.lastname: Hughlett
authors.forename: P D
authors.initials: PD
authors.lastname: Purdy
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D004558:Electric Stimulation; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D008953:Models, Anatomic; D012535:Scalp / Q000502:physiology