Antibody response to rat erythrocytes and some behaviors in two strains of mice after social isolation.
The purpose of this research was twofold: (a) To find out if the antibody response and some behaviors are differential traits for mice (murine strains C57BL/6 and BALB/c); and (b) to study the influence of strain and isolation on both behavior and the antibody response. We used 21 C57BL/6 male mice and 28 BALB/c male mice; of these, 11 C57BL/6 and 16 BALB/c were kept isolated. The rest were housed 2 mice to a cage. We used three open-field tests (of varying light and sound stimulation), a holeboard test, and a light-darkness test. All the mice were immunized with rat erythrocytes. In addition, the mice were weighed. The traits that best differentiated both strains were weight, IgM primary response, and emotional behavior (behaviors in stimulating open fields). Social isolation (of adult mice) influenced emotional behavior, but not the antibody response.
Fusté
A
A
School of Psychology, University of Barcelona, Spain.
Vidal
J
J
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D001143:Arousal / Q000502:physiology*; D004912:Erythrocytes / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D051381:Rats; D017207:Rats, Sprague-Dawley; D012934:Social Isolation