title: Kanamycin concentrations in synovial fluid after intramuscular administration in the horse.
abstract: Six adult ponies were injected in the same intramuscular site with kanamycin sulphate (10 mg/kg). Two hours later, arthrocenteses of the right metacarpophalangeal, radio-carpal, intercarpal, tibio-tarsal and metatarsophalangeal joints were performed within 3 minutes. Arthrocenteses of the same joints on the left side were conducted 5 hours later. When expressed as a percentage of plasma drug concentration, differences in synovial fluid drug concentration between the joints sampled at 2 and 5 hours after injection were not detected.
authors.affiliation: Dept. of General and Large Animal Surgery, State University, Utrecht, The Netherlands.
authors.forename: E C
authors.initials: EC
authors.lastname: Firth
authors.forename: T
authors.initials: T
authors.lastname: Whittem
authors.forename: J F
authors.initials: JF
authors.lastname: Nouws
mesh_terms: D000818:Animals; D006736:Horses / Q000378:metabolism*; D007273:Injections, Intramuscular / Q000662:veterinary; D007612:Kanamycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D007612:Kanamycin