A study of the association between schizophrenia and the dopamine D3 receptor gene.
A study of the genetic association between schizophrenia and a BalI polymorphism in exon 1 of the dopamine D3 (DRD3) gene, a candidate gene for schizophrenia, was conducted. The polymorphism was examined in 91 patients whose symptoms satisfied DSM-III-R for schizophrenia and 90 controls. There were no significant differences between the groups in allele frequencies or genotype counts. Contrary to a previous report, the patients were no more likely to be homozygous than controls. Moreover, no association with the presence of illness could be demonstrated when the patients were grouped according to sex, age of onset, history of admission to psychiatric institutions or positive family history.
Nanko
S
S
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Sasaki
T
T
Fukuda
R
R
Hattori
M
M
Dai
X Y
XY
Kazamatsuri
H
H
Kuwata
S
S
Juji
T
T
Gill
M
M
D000328:Adult; D000483:Alleles; D004247:DNA / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D005091:Exons; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011954:Receptors, Dopamine / Q000235:genetics*; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics*
C493593:DRD3 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D004247:DNA