Sound stimulation increases the cerebral glucose:oxygen quotient in the fetal sheep.
We sought to determine the cerebral metabolic fate of glucose during sound stimulation in near-term fetal sheep. Blood oxygen content was significantly decreased by 6-7% during sound stimulation. The cerebral glucose:oxygen quotient increased from 0.88 +/- 0.08 to 1.13 +/- 0.12 (mean +/- S.E.M., P < 0.01). This is consistent with the phenomenon of stimulated glycolysis which has been shown to increase brain lactate concentration in other models.
Chao
C R
CR
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Glenford
P G
PG
Karibo
E J
EJ
Salha
S D
SD
D000161:Acoustic Stimulation; D000818:Animals; D001784:Blood Gas Analysis; D002540:Cerebral Cortex / Q000737:chemistry* / Q000196:embryology / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000737:chemistry* / Q000378:metabolism; D005947:Glucose / Q000032:analysis* / Q000378:metabolism; D006019:Glycolysis / Q000502:physiology; D010100:Oxygen / Q000032:analysis* / Q000378:metabolism; D011247:Pregnancy; D012756:Sheep / Q000378:metabolism / Q000502:physiology*
D005947:Glucose; D010100:Oxygen