title: Attraction of human monocytes by the neuropeptide secretoneurin.
abstract: Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.
authors.affiliation: Department of Internal Medicine, University of Innsbruck, Austria.
authors.forename: N
authors.initials: N
authors.lastname: Reinisch
authors.forename: R
authors.initials: R
authors.lastname: Kirchmair
authors.forename: C M
authors.initials: CM
authors.lastname: Kähler
authors.forename: R
authors.initials: R
authors.lastname: Hogue-Angeletti
authors.forename: R
authors.initials: R
authors.lastname: Fischer-Colbrie
authors.forename: H
authors.initials: H
authors.lastname: Winkler
authors.forename: C J
authors.initials: CJ
authors.lastname: Wiedermann
mesh_terms: D000818:Animals; D002634:Chemotaxis, Leukocyte; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000166:cytology*; D009479:Neuropeptides / Q000502:physiology*; D051381:Rats; D053381:Secretogranin II
chemical_list: D009479:Neuropeptides; D053381:Secretogranin II; C081159:secretoneurin