Plasma concentrations of lignocaine after thoracic paravertebral blockade in infants and children.
Plasma concentrations of lignocaine were determined in six ASA 1 children treated with thoracic paravertebral blockade. Peak concentrations ranged between 1.7 and 3.0 micrograms.ml-1 after a bolus injection of lignocaine 0.5 ml.kg-1 (lignocaine 10 mg.ml-1 with adrenaline 5 micrograms.ml-1) and peak plasma concentrations were reached 15-30 min after injection. Two hours after the initial bolus a continuous infusion of the same lignocaine solution was started (0.25 ml.kg-1.h-1). Steady state levels of lignocaine were reached 8-10 h after the start of the infusion and ranged from 2.1-3.2 micrograms.ml-1. This regimen for paravertebral block in children resulted in moderate plasma concentrations of lignocaine, well below those which might result in side effects or systemic toxicity.
Lönnqvist
P A
PA
Department of Paediatric Anaesthesia and Intensive Care, St Görans Paediatric Hospital, Karolinska Institute, Stockholm, Sweden.
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008012:Lidocaine / Q000097:blood*; D008297:Male; D009407:Nerve Block / Q000379:methods; D010149:Postoperative Pain / Q000517:prevention & control; D013900:Thoracic Nerves; D013997:Time Factors
D008012:Lidocaine