title: [Elastase-alpha 1-antiprotease in neonatal sepsis].
abstract: Elastase-alpha 1-proteinase inhibitor complex (E-alpha 1-PI) was evaluated in 682 blood samples from 516 newborn infants. They were divided into three groups: control (group 1; n = 99), non-infectious (group 2; n = 338) and infectious (group 3; n = 82). The plasma values of E-alpha 1-PI complex (median; minimum-maximum, in microgram/L) were 180; 46-296 in group 1, 337; 40-2524 in group 2 and 954.5; 183-8160 in group 3. Significant differences were found between the groups (p < 0.001). E-alpha 1-PI complex in blood showed a sensitivity of 75%, specificity of 81.9%, positive predictive value of 30.6% and negative predictive value of 96.8% for the diagnosis of neonatal infection.
authors.affiliation: Sección de Neonatología, Hospital San Joant de Déu, Barcelona.
authors.forename: M
authors.initials: M
authors.lastname: Iriondo Sanz
authors.forename: L
authors.initials: L
authors.lastname: Alvarez Domínguez
authors.forename: A
authors.initials: A
authors.lastname: Riverola de Veciana
authors.forename: I
authors.initials: I
authors.lastname: Lizarraga Vidarrueta
authors.forename: J
authors.initials: J
authors.lastname: Krauel Vidal
mesh_terms: D000704:Analysis of Variance; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D004796:Clinical Enzyme Tests / Q000706:statistics & numerical data; D005069:Evaluation Studies as Topic; D006801:Humans; D007231:Infant, Newborn; D019272:Leukocyte Elastase; D007962:Leukocytes / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000032:analysis*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013030:Spain / Q000453:epidemiology; D000515:alpha 1-Antitrypsin / Q000032:analysis*
chemical_list: D000515:alpha 1-Antitrypsin; C037741:alpha 1-antitrypsin-leukocyte elastase complex; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase
vernacular_title: Elastasa-alpha 1-antiproteasa en la sepsis neonatal.