title: Vacuolated meningioma with secretory features: a case report.
abstract: We report a case of meningioma with secretory features in a 47-year-old woman. The left frontal tumor mass had already eroded the overlying bone at the time of presentation. When respected, the mass showed a gelatinous appearance. Histologically, marked vacuolar change was seen in the stroma. Whorls, psammoma bodies, and pavement arrangement of nuclei were also noted. Periodic acid-Schiff stain revealed cytoplasmic granules, which were digested with diastase. Alcian blue diffusely stained the cytoplasm of the tumor cells. Electron microscopy showed numerous small vacuoles and cored vesicles in the cytoplasm. Glycogen granules were poorly observed. These features indicate the mild secretory nature of this vacuolated meningioma.
authors.affiliation: Department of Laboratory Technology, College of Medical Technology, Hokkaido University.
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Nojima
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Terasaka
authors.forename: T
authors.initials: T
authors.lastname: Aida
authors.forename: H
authors.initials: H
authors.lastname: Abe
mesh_terms: D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008579:Meningioma / Q000378:metabolism / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D014617:Vacuoles / Q000648:ultrastructure*