Anticholinergic agents. 4. Stereocontrolled synthesis of fluorinated acetylcholine antagonists; syntheses of the two 1-cyclohexyl-1-(4-fluorophenyl)-3-piperidyl-1-propanols and their methiodides.
Four new putative muscarinic antagonists, (R)-(-)- and (S)-(+)-1-cyclohexyl-1-(4-fluorophenyl)-3-piperidyl-1-propanol and their methiodides, have been synthesised. Absolute configurations have been assigned on the basis of the anticipated chirality of the products of the Sharpless asymmetric epoxidation reaction.
Sjö
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Department of Pharmacy, University of Oslo, Norway.
Aasen
A J
AJ
D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D007454:Iodides / Q000737:chemistry*; D010276:Parasympatholytics / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014282:Trihexyphenidyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D007454:Iodides; D010276:Parasympatholytics; D014282:Trihexyphenidyl; D000109:Acetylcholine