title: New inhibitors of melanogenesis, OH-3984 K1 and K2. II. Physico-chemical properties and structural elucidation.
abstract: New melanin synthesis inhibitors, OH-3984 K1 and K2, were isolated from the fermentation broth of Streptomyces sp. OH-3984, and their structures were elucidated by spectroscopic methods and by chemical transformations. OH-3984 K1 (M.W.: 306; C18H26O4) and K2 (M.W.: 308; C18H28O4) have unique gamma-lactone rings, both of which correspond to oxidative products derived from C1-O14 cleavage of the 14-membered lactone group.
authors.affiliation: Kitasato Institute, Kitasato University, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takamatsu
authors.forename: M
authors.initials: M
authors.lastname: Rho
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Komiyama
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Omura
authors.forename: G
authors.initials: G
authors.lastname: Imokawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D005285:Fermentation; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D018942:Macrolides; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; C084381:OH 3984 K1; C084382:OH 3984 K2