title: Portal vein infusion of cancer chemotherapeutic agent emulsified with Lipiodol in regenerating liver after partial hepatectomy in rats.
abstract: Portal vein infusion of aclarubicin (ACR) emulsified with Lipiodol (LP) in regenerating liver after 70% partial hepatectomy in rats was evaluated for its safety and usefulness. DNA synthesis in regenerating liver was transiently suppressed by LP, ACR or LP+ACR, but no obvious inhibition was seen in aminopyrine N-demethylase activity and liver weights. LP significantly enhanced hepatic tissue levels of ACR and its active metabolites by long-term retention in the sinusoidal space. This study demonstrates that in rats LP has a powerful effect on the long-term retention of anticancer agents in the sinusoidal space after infusion into the portal vein, without aggravating hepatic damage by anticancer agents.
authors.affiliation: First Department of Surgery, School of Medicine, Chiba University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Kaiho
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Andoh
authors.forename: S
authors.initials: S
authors.lastname: Anbiru
authors.forename: S
authors.initials: S
authors.lastname: Ohtawa
authors.forename: A
authors.initials: A
authors.lastname: Ogata
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects; D016503:Drug Delivery Systems; D004359:Drug Therapy, Combination; D006498:Hepatectomy; D007262:Infusions, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015250:Aclarubicin; D007459:Iodized Oil; D004247:DNA; D000633:Aminopyrine N-Demethylase