title: Cellular versus vascular rejection in transplant kidneys. Correlation of radionuclide and Doppler studies with histology.
abstract: The presence of two distinct subtypes of renal allograft rejection are well documented by histological studies. The differentiation between vascular rejection (VR) and cellular rejection (CR) is essential for proper management by avoiding the need for unnecessary and potentially harmful immunosuppressive treatment of VR. A histological pattern with features that are similar and confusable with some cases of rejection may be seen in cyclosporin A toxicity (CyT). To evaluate the efficiency of Guy's perfusion index (GPI) and the Doppler pulsatility index (DPI) in differentiating these two histological subtypes, a prospective study was designed in which a total of 140 radionuclide tests and 133 ultrasounds scans performed on the same day on 58 patients during the first 3 months post-transplant were analysed, and the results correlated with the histological findings of 84 renal biopsies. Results show that the GPI had a sensitivity of 86.5% and a specificity of 94% in differentiating VR and CyT from CR, while the DPI had values of 83% and 69%, respectively. Chi-squared analysis showed a higher significant association between the GPI and histology (P < 0.0001) compared to that of the DPI and histology (P < 0.005), while Youden's index (J) showed a significant difference (P < 0.05) between GPI and DPI. It is concluded that GPI is more sensitive and specific than DPI in differentiating transplants that are well perfused from those with poor perfusion (VR and CyT).
authors.affiliation: Department of Nuclear Medicine, Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: al-Nahhas
authors.forename: R
authors.initials: R
authors.lastname: Kedar
authors.forename: S H
authors.initials: SH
authors.lastname: Morgan
authors.forename: W N
authors.initials: WN
authors.lastname: Landells
authors.forename: B
authors.initials: B
authors.lastname: al-Murrani
authors.forename: T
authors.initials: T
authors.lastname: Heary
authors.forename: A
authors.initials: A
authors.lastname: Wright
authors.forename: D O
authors.initials: DO
authors.lastname: Cosgrove
authors.forename: M R
authors.initials: MR
authors.lastname: Bending
authors.forename: V R
authors.initials: VR
authors.lastname: McCready
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006084:Graft Rejection / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate; D014465:Ultrasonics; D014463:Ultrasonography
chemical_list: D016284:Technetium Tc 99m Pentetate