New inhibitors of melanogenesis, OH-3984 K1 and K2. II. Physico-chemical properties and structural elucidation.
New melanin synthesis inhibitors, OH-3984 K1 and K2, were isolated from the fermentation broth of Streptomyces sp. OH-3984, and their structures were elucidated by spectroscopic methods and by chemical transformations. OH-3984 K1 (M.W.: 306; C18H26O4) and K2 (M.W.: 308; C18H28O4) have unique gamma-lactone rings, both of which correspond to oxidative products derived from C1-O14 cleavage of the 14-membered lactone group.
Takamatsu
S
S
Kitasato Institute, Kitasato University, Tokyo, Japan.
Rho
M
M
Hayashi
M
M
Komiyama
K
K
Tanaka
H
H
Omura
S
S
Imokawa
G
G
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D005285:Fermentation; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D018942:Macrolides; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; C084381:OH 3984 K1; C084382:OH 3984 K2