Delayed parkinsonism associated with hypotension in a child undergoing open-heart surgery.
An eight-year-old boy developed acute parkinsonism four days after open-heart surgery for repair of a ventriculo-septal defect. During the procedure he experienced a hypotensive episode which required administration of positive-inotropic agents. Complementing the clinical signs of parkinsonism, CT scan showed symmetrical hypodensities in the basal ganglia, and decreased regional cerebral blood flow was demonstrated using 99mTc HMPAO SPECT. These findings were suggestive of a hypoxic-ischaemic insult to the basal ganglia. The child was treated with levodopa/carbidopa and subsequently completely recovered within a follow-up period of eight months. CT scan appearances and cerebral blood flow findings returned to normal. Parkinsonism secondary to a hypoxic-ischaemic insult to basal ganglia in children is a rare but reversible disorder, in contrast to its progressive course which results in severe disability in adults.
Straussberg
R
R
Child Neurology Unit, Chaim Sheba Medical Centre, Tel Hashomer, Israel.
Shahar
E
E
Gat
R
R
Brand
N
N
D000208:Acute Disease; D001479:Basal Ganglia / Q000098:blood supply; D002545:Brain Ischemia / Q000150:complications*; D002648:Child; D006801:Humans; D007022:Hypotension / Q000150:complications*; D002534:Hypoxia, Brain / Q000150:complications*; D007431:Intraoperative Complications; D008297:Male; D010302:Parkinson Disease, Secondary / Q000209:etiology*; D011183:Postoperative Complications; D013771:Tetralogy of Fallot / Q000601:surgery*