[Neurologic complications induced by the treatment of the acute renal allograft rejection with the monoclonal antibody OKT3].
The treatment of the acute renal allograft rejection with the monoclonal antibody orthoclone OKT3 produces both systemic and neurologic alterations. In a series of 21 patients with an acute renal allograft rejection treated with this monoclonal antibody, 20 with a renal allograft transplantation and one with a renal and pancreatic allograft transplantation, 29% referred headache associated with fever and vomiting, and 14.2% presented severe neurological alterations induced by the treatment. We stress the need to know these secondary effects to differentiate them from other central nervous system disorders, particularly those of infectious origin.
Fernández
O
O
Servicio de Neurología, Hospital Regional de Málaga.
Romero
F
F
Bravo
M
M
Burgos
D
D
Cabello
M
M
González-Molina
M
M
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016853:Muromonab-CD3 / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D016853:Muromonab-CD3
Complicaciones neurológicas del tratamiento del rechazo agudo del alotrasplante renal con el anticuerpo monoclonal Orthoclone OKT3.