Cocaine induces rapid loss of intracellular free Mg2+ in cerebral vascular smooth muscle cells.
Acute exposure of cultured canine cerebral vascular smooth muscle cells to low concentrations of cocaine HCl (10(-9) to (10(-7) M) resulted in significant, rapid (1 min) loss of intracellular free Mg ions ([Mg2+]i); these reductions (12-25%) in [Mg2+]i were reversible upon exposure to normal, Mg(2+)-containing physiological salt solution. These findings help to provide a rational basis for why cocaine can result in cerebrovasospasm and stroke.
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Department of Physiology, State University of New York Health Science Center at Brooklyn 11203.
Zhang
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Cheng
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D000818:Animals; D001921:Brain / Q000098:blood supply*; D002478:Cells, Cultured; D002561:Cerebrovascular Disorders / Q000139:chemically induced / Q000378:metabolism; D003042:Cocaine / Q000494:pharmacology*; D004285:Dogs; D002534:Hypoxia, Brain / Q000139:chemically induced; D002546:Ischemic Attack, Transient / Q000139:chemically induced; D008274:Magnesium / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010758:Phosphorus
D010758:Phosphorus; D008274:Magnesium; D003042:Cocaine