title: [Clozapine in long-term treatment of schizophrenic patients].
abstract: Clozapine has advantages over standard antipsychotics in refractory schizophrenia. Studies on the efficacy of clozapine in the maintenance treatment are sparse and suffer from methodological limitations. Despite this fact clozapine ranked second in a survey dealing with the preference of this antipsychotic in the long-term treatment of schizophrenia. Doctors report on using a mean of 130 mg/d in this indication which is considerably less than the doses used in most of the published long-term trials. The discrepancy between the popularity of clozapine and the lack of sound empirical data on its long-term efficacy is discussed.
authors.affiliation: Univ.-Klinik für Psychiatrie Innsbruck.
authors.forename: U
authors.initials: U
authors.lastname: Meise
authors.forename: M
authors.initials: M
authors.lastname: Kurz
authors.forename: W W
authors.initials: WW
authors.lastname: Fleischhacker
mesh_terms: D001291:Attitude of Health Personnel; D001317:Austria; D003024:Clozapine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004363:Drug Utilization / Q000639:trends; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D003024:Clozapine
vernacular_title: Clozapin in der Langzeitbehandlung schizophrener Patienten.