title: [Short-term and long-term effects on glycosylated hemoglobin after transition from conventional insulin treatment to multiple insulin injection regime in a diabetic outpatient clinic].
abstract: In order to examine the short- and long term effects of basal/bolus insulin therapy on the metabolic regulation assessed by glycosylated haemoglobin (HbA1c) the first 201 patients in the diabetes out-patient clinic of the Section of Endocrinology, Department of Medicine, Aalborg Hospital, assigned for this treatment were prospectively studied. In all 201 patients a significant decrease in mean HbA1c value was observed after 21 months on multiple injection therapy (8.5% vs 8.1%; p < 0.001). The higher the HbA1c value on conventional therapy, the greater was the observed decrease in HbA1c following six months on basal/bolus therapy (r = 0.57, p < 0.001). According to an anonymous questionnaire completed by the first 140 patients six months after the start of multiple injection therapy, 97% of the patients preferred to continue with basal/bolus therapy with NovoPen, and 87% felt that they had achieved a better general condition and that the basal/bolus regime made their daily life easier. It is concluded that basal/bolus therapy with NovoPen may combine the attainment of improved metabolic control assessed by a decrease in mean HbA1c in many poorly regulated patients and the subjective experience of an improved quality of life.
authors.affiliation: Aalborg Sygehus, medicinsk-endokrinologisk afdeling.
authors.forename: M K
authors.initials: MK
authors.lastname: Jensen
authors.forename: J
authors.initials: J
authors.lastname: Ditzel
authors.forename: H H
authors.initials: HH
authors.lastname: Lervang
authors.forename: S
authors.initials: S
authors.lastname: Jensen
authors.forename: J O
authors.initials: JO
authors.lastname: Pedersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D003718:Denmark; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007277:Injections, Jet; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin
vernacular_title: Kort- og langtidseffekten på glykosyleret haemoglobin ved overgang fra konventionel insulinbehandling til multipel insulininjektionsregi i et diabetesambulatorium.