[The production and significance of interleukin-4 in patients with idiopathic nephrotic syndrome].
Samples of serum and PBMC were collected at the same time from 42 pediatric patients with idiopathic nephrotic syndrome (INS) and 28 age-matched healthy individuals. The level of IgE in serum was detected and IL4 in supernatant of PHA-activated PBMC assayed by sandwich ELISA. The level of IL4 and IgE in healthy individuals was 400-500 pg/ml and 50-100 U/ml respectively, and that of IL4 and IgE in the INS patients was on the average 1,080-4,000 pg/ml and 380-1,000 U/ml. Positive correlations were noted between the levels of IL4 and IgE, IL4, and quantity of proteinuria in 24 hours in the INS patients. It is suggested that the elevated IgE in the INS patients was induced by the elevated IL4, and that the imbalanced function of T cells and IL4 was contributable to INS.
Yao
Z
Z
Department of Immunology, Beijing Medical University.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D015847:Interleukin-4 / Q000097:blood*; D009404:Nephrotic Syndrome / Q000276:immunology*; D012008:Recurrence
D015847:Interleukin-4; D007073:Immunoglobulin E