title: [Effects of nicardipine on hemodynamics and skin blood flow--comparison between N2O-sevoflurane and N2O-isoflurane anesthesia].
abstract: Dividing the surgical patients into GOS (N2O-oxygen-sevoflurane anesthesia) group and GOI (N2O-oxygen-isoflurane anesthesia) group, we studied the effects of nicardipine on hemodynamics and skin blood flow under each anesthetic method. Control measurements were taken when the hemodynamic parameters were stable during surgery and the incremental doses of nicardipine (0.5 mg) were administered up to a total of 2.0 mg. The changes in hemodynamic parameters and skin blood flow were measured at the nicardipine dosage of 0.5 mg (S1), 1.0 mg (S2), 1.5 mg (S3), and 2.0 mg (S4). Heart rate tended to increase in both groups. Blood pressure, on the other hand, decreased at S1 and S2, but showed little change at S3 and S4 in both groups. Skin blood flow tended to increase in the GOS group, but in the GOI group little change in skin blood flow was noted at S1-S3. Skin blood flow tended to decrease at S4 in the GOI group.
authors.affiliation: Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
authors.forename: M
authors.initials: M
authors.lastname: Kobori
authors.forename: H
authors.initials: H
authors.lastname: Negishi
authors.forename: A
authors.initials: A
authors.lastname: Hosoyamada
mesh_terms: D000769:Anesthesia, Inhalation; D000777:Anesthetics; D001775:Blood Circulation / Q000187:drug effects; D004987:Ethers; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007530:Isoflurane; D008738:Methyl Ethers; D009529:Nicardipine / Q000494:pharmacology*; D009609:Nitrous Oxide; D000077149:Sevoflurane; D012867:Skin / Q000098:blood supply*
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D009529:Nicardipine; D009609:Nitrous Oxide