Vasodilator action of cromakalim on human mesenteric artery.
Human mesenteric artery rings (1-3 mm diameter obtained from bowel resections), precontracted with KCl 80 mM, were relaxed by cromakalim (IC50 = 0.39 +/- 0.04 microM, maximum inhibition 69 +/- 2%). Cromakalim was more effective at inhibiting KCl 40 mM than KCl 80 mM. Cromakalim also inhibited contraction produced by noradrenaline, and was a more potent inhibitor of the second phase of the noradrenaline contraction than of the first phase.
McDonald
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A
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, UK.
MacDonald
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E
Wadsworth
R M
RM
Scott
P J
PJ
D000368:Aged; D000369:Aged, 80 and over; D001578:Benzopyrans / Q000494:pharmacology*; D019806:Cromakalim; D006801:Humans; D066298:In Vitro Techniques; D008638:Mesenteric Arteries / Q000187:drug effects*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D001578:Benzopyrans; D011758:Pyrroles; D014665:Vasodilator Agents; D019806:Cromakalim; D011189:Potassium Chloride; D009638:Norepinephrine