[Acute adrenal failure due to adrenal hemorrhagic necrosis secondary to heparin-induced thrombocytopenia].
The authors describe a clinical case with a peculiar sequence of unhealthy events. An operated by osteotomy woman presented a deep venous thrombosis of lever lower extremity with following pulmonary embolism. The patient was treated with heparin. After 5 days, the patient showed a thrombocytopenia, that was not determined by an immune mechanism. The heparin was stopped and the thrombocythemia returned to normal values. But the patient still presented somnolence, asthenia and hypotension. The tests of adrenocortical function showed below normal values. The abdominal CAT showed haemorrhagic necrosis of the suprarenal glands.
Santonastaso
M
M
Divisione di Lungodegenza Riabilitativa, Ospedale, ULSS 12, Conegliano, Treviso.
Bovo
P
P
Colaceci
R
R
Corbanese
U
U
Ruga
P
P
D000208:Acute Disease; D000311:Adrenal Glands / Q000473:pathology*; D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000209:etiology*; D000368:Aged; D005260:Female; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D009336:Necrosis; D010027:Osteotomy; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology*; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy / Q000209:etiology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications*; D013924:Thrombophlebitis / Q000150:complications / Q000188:drug therapy
D006493:Heparin
Insufficienza surrenalica acuta da necrosi emorragica surrenalica secondaria a trombocitopenia indotta da eparina.