Perfragilins A and B, cytotoxic isoquinolinequinones from the bryozoan Membranipora perfragilis.
Detailed spectroscopic and cytotoxicity data are reported for two new isoquinolinequinones, perfragilins A [1] and B [2], which were isolated from the bryozoan Membranipora perfragilis collected in South Australia. Both compounds, which are speculated to be of microbial origin, contain a relatively uncommon thiomethyl ether functionality.
Choi
Y H
YH
Department of Chemistry, University of Oklahoma, Norman 73019.
Park
A
A
Schmitz
F J
FJ
van Altena
I
I
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D002013:Bryozoa / Q000737:chemistry*; D007546:Isoquinolines / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013021:South Australia; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D016227:Benzoquinones; D007546:Isoquinolines; C080170:perfragilin A