title: [Pharmacological support during orthodontic therapy with a topical anti-inflammatory].
abstract: On the occasion of many orthodontic procedures is often necessary to use NSAIDs in order to provide relief from the inflammatory and painful symptoms originating by removable and permanent devices. In this single blind controlled study, efficacy and tolerability of a topical antiinflammatory drug, formulated as mouth wash containing flurbiprofen 0.25%, have been evaluated in 60 patients (range 12-16 years) suffering from tissular injuries caused by permanent devices. Following a randomisation list, the patients were allocated to 3 different balanced groups, the first received flurbiprofen mouth wash 10 ml, 3 times daily for 7 days, the second received placebo mouth wash in the same way and the third group was a control one. The aim of the trial was to evaluate the pain symptom related to the injuries. The result of the study shows statistical improvement in favour of flurbiprofen in comparison to the placebo as well as to the control group. No local or systemic ADRs were reported.
authors.affiliation: Clinica Odontoiatrica, Università degli Studi di Brescia.
authors.forename: C
authors.initials: C
authors.lastname: Paganelli
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D002648:Child; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009067:Mouthwashes; D009971:Orthodontics, Corrective; D010147:Pain Measurement; D016037:Single-Blind Method
chemical_list: D009067:Mouthwashes; D005480:Flurbiprofen
vernacular_title: Sussidi farmacologici in corso di terapia ortodontica con un antinfiammatorio per uso topico.