Genetic-based differences in neurotensin levels and receptors in brains of LS x SS mice.
Levels of endogenous neurotensin (NT-IR) in the LS x SS RI strains differed by 3.0-, 4.7-, 5.4-, and 6.9-fold in the ventral midbrain (VMB), hypothalamus (HY), nucleus accumbens (NA), and caudate putamen (CP), respectively. Frequency distributions and estimates of the number of genes indicate that differences in NT-IR are polygenically influenced. The NT-IR levels in NA and CP were significantly correlated, but levels in the VMB did not correlate with those in the NA or CP. Specific binding to either low (NTL)- or high (NTH)-affinity receptors as measured in the absence or presence of levocabastine differed significantly in brain regions from among LS X SS mouse strains. Results indicate a polygenic influence mediating the differences in receptor densities and suggest differences in genetic regulation of NTL and NTH receptors.
Erwin
V G
VG
Alcohol Research Center, School of Pharmacy, University of Colorado, Health Sciences Center, Denver 80262.
Radcliffe
R
R
Hinkle
B
B
Jones
B C
BC
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D005838:Genotype; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009496:Neurotensin / Q000235:genetics / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism; D011699:Putamen / Q000378:metabolism; D011863:Radioimmunoassay; D018028:Receptors, Neurotensin / Q000235:genetics / Q000378:metabolism*
D018028:Receptors, Neurotensin; D009496:Neurotensin