Propofol improves patient comfort during cisplatin chemotherapy. A pilot study.
20 consecutive patients with nausea and vomiting secondary to cisplatin chemotherapy uncontrolled by serotonin-antagonist and corticosteroid prophylaxis during their first cycle received adjuvant propofol. This new anesthetic agent was added at subhypnotic doses, i.e. 1 mg/kg/h, as a continuous intravenous infusion during the two subsequent chemotherapy cycles. In 85 and 90% of patients, nausea and vomiting were prevented in the first 24 h following the first and second propofol-supplemented chemotherapy cycles respectively. 24-72 h postchemotherapy, this side effect remained suppressed in 75 and 70% of patients, respectively. Patients' comfort and appetite were improved. All 20 subjects preferred the propofol-containing regimen.
Borgeat
A
A
Department of Anaesthesiology, Geneva University Hospital, Switzerland.
Wilder-Smith
O H
OH
Wilder-Smith
C H
CH
Forni
M
M
Suter
P M
PM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001066:Appetite; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D017829:Granisetron / Q000627:therapeutic use; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D017294:Ondansetron / Q000627:therapeutic use; D010865:Pilot Projects; D015742:Propofol / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D002945:Cisplatin; D003907:Dexamethasone; D017829:Granisetron; D017294:Ondansetron; D015742:Propofol