Attraction of human monocytes by the neuropeptide secretoneurin.
Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.
Reinisch
N
N
Department of Internal Medicine, University of Innsbruck, Austria.
Kirchmair
R
R
Kähler
C M
CM
Hogue-Angeletti
R
R
Fischer-Colbrie
R
R
Winkler
H
H
Wiedermann
C J
CJ
D000818:Animals; D002634:Chemotaxis, Leukocyte; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000166:cytology*; D009479:Neuropeptides / Q000502:physiology*; D051381:Rats; D053381:Secretogranin II
D009479:Neuropeptides; D053381:Secretogranin II; C081159:secretoneurin