title: The interaction of 2,4-dichlorophenoxyacetic acid, ribosomes and polyamines in Azospirillum brasilense.
abstract: 2,4-Dichlorophenoxyacetic acid (2,4-D) is an herbicide used extensively in agriculture. We had previously determined that 1 mM 2,4-D could inhibit cell growth, DNA and protein synthesis of Azospirillum brasilense. The present work was designed to determine if these alterations are a consequence of 2,4-D action on polyamine biosynthesis and if the protein synthesis inhibition is a result of ribosomal impairment. In this paper we demonstrate that 2,4-D alters the metabolism of polyamines and, thus, affects protein synthesis at the ribosomal level.
authors.affiliation: Facultad de Ciencias Exactas, Universidad Nacional de Rio Cuarto, Córdoba, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Fabra
authors.forename: W
authors.initials: W
authors.lastname: Giordano
authors.forename: V
authors.initials: V
authors.lastname: Rivarola
authors.forename: G
authors.initials: G
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Castro
authors.forename: H
authors.initials: H
authors.lastname: Balegno
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D015806:Azospirillum brasilense / Q000187:drug effects* / Q000378:metabolism; D015317:Biogenic Polyamines / Q000096:biosynthesis* / Q000494:pharmacology; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism
chemical_list: D015317:Biogenic Polyamines; D015084:2,4-Dichlorophenoxyacetic Acid