Binding of a specific subclass of immunoglobulins by a human seminal plasma component.
Human seminal plasma contains a component that binds immunoglobulins (Ig). The Ig binding factor was purified by ammonium sulphate precipitation, preparative isoelectrofocusing and gel filtration chromatography and found to bind strongly human IgGl and mouse IgM. This seminal plasma component may possess immunosuppressive activity and may modulate the activities of the immunosurveillance system of the reproductive tract.
Liang
Z G
ZG
Center for Biomedical Research, Population Council, New York, NY 10021.
Kamada
M
M
Koide
S S
SS
D000818:Animals; D002850:Chromatography, Gel; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism*; D066298:In Vitro Techniques; D007525:Isoelectric Focusing; D008222:Lymphokines / Q000302:isolation & purification / Q000378:metabolism*; D008297:Male; D051379:Mice; D008970:Molecular Weight; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000302:isolation & purification / Q000378:metabolism*; D012661:Semen / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000302:isolation & purification / Q000378:metabolism
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D013491:Suppressor Factors, Immunologic; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors