title: Comparative effect of synthetic aminoestrogens with estradiol on platelet aggregation.
abstract: The in vitro effect upon platelet aggregation of estradiol and synthetic estrogens (prolame, buame, and proacame) is described. Prolame and buame produced a dose-dependent inhibition on platelet aggregation. Estradiol and proacame did not show anti-aggregating effects. The results suggest that the use of prolame and buame in estrogen therapy could reduce the risk of thrombo-embolic accidents.
authors.affiliation: Instituto Nacional de Cardiología Ignacio Chávez, Departmento de Hemantología, México, D.F.
authors.forename: A
authors.initials: A
authors.lastname: De la Peña
authors.forename: G
authors.initials: G
authors.lastname: Baños
authors.forename: R
authors.initials: R
authors.lastname: Izaguirre
authors.forename: J J
authors.initials: JJ
authors.lastname: Mandoki
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández
mesh_terms: D000328:Adult; D004958:Estradiol / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000494:pharmacology*; D004962:Estranes / Q000494:pharmacology; D004963:Estrenes / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
chemical_list: D045166:Estradiol Congeners; D004962:Estranes; D004963:Estrenes; D010975:Platelet Aggregation Inhibitors; C083898:proacame; C083897:buame; D004958:Estradiol; C047867:prolame