3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?
Pirotte
B
B
Laboratoire de Chimie Pharmaceutique, Université de Liège, Belgium.
de Tullio
P
P
Lebrun
P
P
Antoine
M H
MH
Fontaine
J
J
Masereel
B
B
Schynts
M
M
Dupont
L
L
Herchuelz
A
A
Delarge
J
J
D000818:Animals; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013829:Thiadiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D007328:Insulin; D015221:Potassium Channels; D011725:Pyridines; D013829:Thiadiazines