[Percutaneous coronary angioplasty and levels of endothelin-1 in blood].
The aim of this study was to assess plasma endothelin-1 (ET) concentrations during percutaneous transluminal coronary angioplasty (PTCA) of the left anterio descending coronary artery (LAD). We also examined relations between plasma concentrations of ET and diameter of the PTCA-balloon. Plasma levels of ET determined by radioimmunoassay were measured in 24 patients (pts) without previous myocardial infarction undergoing PTCA of LAD. The pts were divided into two groups. In group 1 (12 pts) plasma ET levels were measured in the right atrium and in the forearm vein 24 hours before PTCA, and 5 minutes after the last balloon deflation. In group 2 (12 pts) concentrations of ET were measured only in venous blood: 24 hours before PTCA, just before PTCA, 5 minutes after last balloon deflation and 24 hours later. We compared the diameter of the inflated balloon with the diameter of the dilated artery [balloon/artery ratio /b/a ratio/] and correlated it with plasma ET concentration rise in every case. [table: see text] The mean b/a ratio correlated with plasma ET concentrations after PTCA (r = 0.677 p < 0.001).


CONCLUSIONS
Plasma ET concentrations do not rise after non complicated PTCA procedure. Because plasma ET levels depend on b/t ratio it is very important that the diameter of the dilating balloon should correspond with the diameter of the coronary artery to avoid overdilation.
Chmielk
Z
Z
II Samodzielnej Pracowni Hemodynamiki, Zakładu Biochemii, Warszawie.
Pszona
B
B
Dabrowski
M
M
Witkowski
A
A
Ruzyłło
W
W
D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000097:blood* / Q000628:therapy; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011863:Radioimmunoassay
D016232:Endothelins
Zabieg przezskornej angioplastyki tetnicy wieńcowej a stezenie endoteliny-1 we krwi.