[A study on the transcriptional expression of oncogenes in human primary brain tumors].
The c-myc, L-myc, N-myc, Ha-ras, c-fos, and v-erbB oncogenes were used as probes to detect the total RNA of 5 cases of normal human brain tissues and 29 cases of brain tumor tissues by RNA dot hybridization analysis. The results showed that the increasing expressions of cerbB and c-fos were the highest, being 88.2% and 82.4%, respectively, the next was c-myc with an increased expression of 46.1%; the increasing expressions of L-myc (29.3%) and N-myc (31.6%) were observed in a few samples only. There was no significant difference of Ha-ras gene expression between normal brain and brain tumor. In addition, we observed the increasing expression of more than one oncogene in one sample. These results suggest that c-erbB and c-fos oncogenes may play an important role in the pathogenesis of human primary brain tumors, and that multiple genetic changes are implicated in genesis of human brain tumors.
Sun
N
N
Wen
Y
Y
Yan
S
S
Sun
Z
Z
Zhou
R
R
Liao
W
W
D001932:Brain Neoplasms / Q000235:genetics*; D015870:Gene Expression; D016762:Genes, fos; D016259:Genes, myc; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics; D008579:Meningioma / Q000235:genetics; D009455:Neurofibroma / Q000235:genetics; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012334:RNA, Neoplasm / Q000032:analysis; D014158:Transcription, Genetic
D012334:RNA, Neoplasm