title: Interleukin-10 inhibits endotoxin-induced tissue factor mRNA production by human monocytes.
abstract: In Gram-negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin-10 (IL-10) on endotoxin-induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in septic shock, a condition still associated with a high mortality rate.
authors.affiliation: INSERM U294, CHU Xavier Bichat, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Ramani
authors.forename: V
authors.initials: V
authors.lastname: Ollivier
authors.forename: F
authors.initials: F
authors.lastname: Khechai
authors.forename: T
authors.initials: T
authors.lastname: Vu
authors.forename: C
authors.initials: C
authors.lastname: Ternisien
authors.forename: F
authors.initials: F
authors.lastname: Bridey
authors.forename: D
authors.initials: D
authors.lastname: de Prost
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000502:physiology*; D007700:Kinetics; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D013925:Thromboplastin / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D008070:Lipopolysaccharides; D012333:RNA, Messenger; D016753:Interleukin-10; D013925:Thromboplastin