Vitamin K-dependent clotting factors are elevated in young adults who have close relatives with ischemic heart disease.
An increase in factor VII was found to be a risk factor for ischemic heart disease. The present study was designed to test the hypothesis that this increase in factor VII is part of a general increase in vitamin K-dependent clotting factors. Initially, a prospective analysis of factor VII antigen and prothrombin activity was performed in two groups of young subjects without symptoms who differed in their risk of ischemic heart disease based on a history (or lack thereof) of premature heart disease in a first-degree relative. A statistically significant increase in prothrombin activity and factor VII antigen was found in the high-risk group of subjects when compared with the low-risk group. In a second series of subjects, factor IX and X activity assays were also performed, and all four of the vitamin K-dependent clotting factors were found to be significantly higher in high-risk subjects when compared with low-risk subjects. A second goal of the study was to explore whether correlations between factor VII and cholesterol and triglycerides might be due to binding of factor VII with apolipoprotein B. Although a significant correlation of factor VII antigen with apolipoprotein B (rho = 0.523, p < 0.025) was found in our high-risk group of subjects, the correlation between factor VII and triglycerides (rho = 0.641, p < 0.005) was even stronger statistically, suggesting a probable interaction of factor VII with very-low-density lipoproteins in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)
Burns
P
P
Department of Medicine, State University of New York, at Stony Brook 11794-8151.
Hoffman
C J
CJ
Katz
J P
JP
Miller
R H
RH
Lawson
W E
WE
Hultin
M B
MB
D000328:Adult; D001055:Apolipoproteins B / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D005164:Factor IX / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000235:genetics*; D011446:Prospective Studies; D011516:Prothrombin / Q000378:metabolism; D012044:Regression Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014812:Vitamin K / Q000494:pharmacology*
D001055:Apolipoproteins B; D001779:Blood Coagulation Factors; D014280:Triglycerides; D014812:Vitamin K; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; D002784:Cholesterol