title: The effect of carbamazepine on endocrine and sleep EEG variables in a patient with 48-hour rapid cycling, and healthy controls.
abstract: Carbamazepine treatment of a patient with 48-hour rapid cycling led to a dampening of mood cycling, and prolonged rapid eye movement (REM) sleep latency. No effect on central alpha-receptors as measured by growth hormone (GH) secretion after clonidine stimulation or on spontaneous 48-hour GH secretion was observed. In 12 healthy subjects given 400 mg carbamazepine daily for a period of 5 days, improved sleep continuity and increased slow-wave sleep occurred with treatment. REM sleep percentage and REM latency remained uninfluenced, whereas REM density decreased. GH secretion after clonidine stimulation was not altered. Data from the single-case longitudinal study emphasize that carbamazepine is effective in treating rapid-cycling affective psychosis. Furthermore, neuroendocrine and sleep EEG data from the study in healthy subjects indicate a different profile of action for carbamazepine compared to most other antidepressants or antimanic drugs.
authors.affiliation: Central Institute of Mental Health, Mannheim, FRG.
authors.forename: D
authors.initials: D
authors.lastname: Riemann
authors.forename: H
authors.initials: H
authors.lastname: Gann
authors.forename: F
authors.initials: F
authors.lastname: Hohagen
authors.forename: M
authors.initials: M
authors.lastname: Bahro
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Berger
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D002220:Carbamazepine / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D003000:Clonidine; D004569:Electroencephalography / Q000187:drug effects*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D006728:Hormones; D002220:Carbamazepine; D003000:Clonidine