[Role of the endothelium in the control of vascular motility: physiologic aspects and physiopathologic implications in cardiovascular diseases].
It was recently demonstrated that vascular endothelium produces many substances which modulate the vascular tone by acting locally (endothelium derived relaxing factor, angiotensin II, endothelin, prostacyclin). The authors review the physiological regulatory role of these substances and their involvement in cardiovascular diseases. They also consider the interaction between the endothelium derived factors and some cardiovascular drugs (such as calcium antagonists and ACE-inhibitors) and also the mechanisms of the possible protective action of these drugs on the vascular wall.
Limone
P
P
Istituto di Medicina Interna, Università degli Studi di Torino.
Boeri
E
E
Molinatti
G M
GM
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D016232:Endothelins / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D011464:Epoprostenol / Q000502:physiology; D006133:Growth Substances; D006331:Heart Diseases / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D009569:Nitric Oxide / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D016232:Endothelins; D006133:Growth Substances; D009569:Nitric Oxide; D011464:Epoprostenol
Ruolo dell'endotelio nel controllo della motilità vascolare: aspetti fisiologici ed implicazioni fisiopatologiche nelle malattie cardiovascolari.