title: Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats.
abstract: Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshiyama
authors.forename: S
authors.initials: S
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: F
authors.initials: F
authors.lastname: Tomonaga
authors.forename: S
authors.initials: S
authors.lastname: Ohdo
authors.forename: N
authors.initials: N
authors.lastname: Ogawa
authors.forename: S
authors.initials: S
authors.lastname: Nakano
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D002940:Circadian Rhythm; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D007279:Injections, Subcutaneous; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; C016927:isepamicin