title: Anxiety sensitivity and response to cholecystokinin tetrapeptide in healthy volunteers.
abstract: The authors determined whether fear of anxiety symptoms mediates panicogenic responses to cholecystokinin tetrapeptide (CCK-4) in healthy subjects. Individuals with a preexisting high level of anxiety sensitivity (N = 10) experienced significantly more catastrophic cognitions and fear of somatic symptoms than did subjects with low (N = 9) or medium (N = 17) anxiety sensitivity, but they were not more susceptible to experiencing a panic attack. Thus, cognitive factors do not appear to be critical determinants of CCK-4-induced panic attacks.
authors.affiliation: Department of Psychiatry, St. Mary's Hospital Center, Montreal, Que., Canada.
authors.forename: D
authors.initials: D
authors.lastname: Koszycki
authors.forename: B J
authors.initials: BJ
authors.lastname: Cox
authors.forename: J
authors.initials: J
authors.lastname: Bradwejn
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000139:chemically induced*; D001794:Blood Pressure / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D005239:Fear / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000139:chemically induced*; D010555:Personality Inventory; D013758:Tetragastrin / Q000494:pharmacology*
chemical_list: D013758:Tetragastrin