The value of luteal support with progesterone in gonadotropin-induced cycles.
OBJECTIVE
To evaluate the effect of luteal support with vaginal P suppositories in hMG- and hCG-induced cycles.


METHODS
Between March 1988 and February 1989 patients did not receive luteal support, while between March 1989 and January 1990 P was given routinely in the luteal phase. Induction protocol and patient selection remained otherwise unchanged.


METHODS
Infertility clinic of a tertiary care hospital.


METHODS
Twenty-seven patients with hypogonadotropic amenorrhea (World Health Organization [WHO] group I) (11 women with luteal support, 16 women without) and 102 patients with euprolactinemic clomiphene citrate (CC)-resistant anovulation (WHO group II) (52 women with luteal support, 50 women without).


METHODS
Vaginal P suppositories 200 mg/d in the luteal support group.


METHODS
Pregnancy rate (PR), pregnancy outcome.


RESULTS
The overall PR in 118 cycles with luteal support was 26.3% whereas 10.4% pregnancies were achieved in 115 cycles of the control group. The influence of luteal support was more pronounced in patients with CC-resistant anovulation (25.2% versus 6.9%) than in patients with hypogonadotropic amenorrhea (33.3% versus 21.4%, not significant). The abortion rate was not significantly changed.


CONCLUSIONS
Luteal support with P increases the PR after hMG and hCG induction. The need for supplementary P seems to be related to the underlying cause of ovarian disturbance.
Hamilton
C J
CJ
Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Jaroudi
K A
KA
Sieck
U V
UV
D000022:Abortion, Spontaneous; D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D003338:Corpus Luteum / Q000187:drug effects; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use*; D010062:Ovulation Induction; D010570:Pessaries; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D012189:Retrospective Studies
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins