title: Pyridostigmine toxicity. Electrophysiological study.
abstract: A 54-year-old neurotic patient developed pyridostigmine-induced proximal weakness with daily 3600 mg of pyridostigmine. Detailed analysis of the RNS test showed three different types of responses which were reproduced in the in vitro nerve-muscle preparation, confirming that three different responses represent the different degree of pyridostigmine toxicity. One of responses was a pattern, thought to be typical of anticholinesterase toxicity: repetitive discharge and the maximal decrement in the second response followed by an increment (dip phenomenon). With reduction of pyridostigmine, clinical and electrophysiological improvement followed.
authors.affiliation: Department of Neurology, University of Alabama at Birmingham.
authors.forename: K H
authors.initials: KH
authors.lastname: Park
authors.forename: D E
authors.initials: DE
authors.lastname: Kim
authors.forename: T W
authors.initials: TW
authors.lastname: Arnold
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
authors.forename: R
authors.initials: R
authors.lastname: Bradley
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D004576:Electromyography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D011729:Pyridostigmine Bromide / Q000009:adverse effects*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D011729:Pyridostigmine Bromide