title: Impact of regional and total body composition and hormones on resting energy expenditure in overweight postmenopausal women.
abstract: The independent impact of regional and total body composition and sex and thyroid hormone levels on resting energy expenditure (REE) was assessed in 121 healthy, overweight (body mass index [BMI], 25 to 42 kg/m2), postmenopausal women (aged 49 to 58 years). REE was measured by indirect calorimetry with a ventilated hood, and the total, trunk, and peripheral body composition by dual-energy x-ray absorptiometry (DXA). Sex and thyroid hormone levels were also measured. REE correlated significantly (P < .05) better with trunk lean tissue mass ([LTM] r = .61) than with total-body (r = .53) or peripheral LTM (r = .30). Trunk LTM (R2 = .37), total-body fat tissue mass ([FTM] R2 = .04), androstenedione (R2 = .03), and total triiodothyronine ([T3] R2 = .02) were all significantly independently associated with REE. Together they explained 46% (model R2) of the interindividual variation in REE, with a standard error of estimate (SEE) of 549 kJ/d. We conclude that the interindividual variation in REE is explained mainly by differences in the visceral component of LTM, with additional minor information from the total-body FTM, androstenedione, and T3.
authors.affiliation: Center for Clinical and Basic Research, Ballerup, Denmark.
authors.forename: O L
authors.initials: OL
authors.lastname: Svendsen
authors.forename: C
authors.initials: C
authors.lastname: Hassager
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
mesh_terms: D015502:Absorptiometry, Photon; D000735:Androstenedione / Q000097:blood; D001481:Basal Metabolism; D001823:Body Composition; D015992:Body Mass Index; D002151:Calorimetry; D004734:Energy Metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D017698:Postmenopause / Q000502:physiology*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D006728:Hormones; D012738:Sex Hormone-Binding Globulin; D014284:Triiodothyronine; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D013974:Thyroxine