Neurogranin, a B-50/GAP-43-immunoreactive C-kinase substrate (BICKS), is ADP-ribosylated.
Neurogranin is a neurone-specific, B-50-immunoreactive C-kinase substrate that has limited homology to, but considerable biochemical similarity to B-50/GAP43. The most significant differences between these two proteins are their cellular localisation and molecular mass (Neurogranin, 7.5 kDA cytosolic; and B-50, 25 kDa membranal). An understanding of the similarities and differences between Neurogranin and B-50 may facilitate the elucidation of their hitherto elusive functions in the nervous system. The results of the present study demonstrate that, in common with B-50, Neurogranin is a substrate for ADP-ribosyltransferase. This finding is discussed with regard to the concept of molecular flexibility of B-50-like proteins as the basis of their putatively diverse roles in the nervous system.
Coggins
P J
PJ
Department of Medical Physiology, University of Calgary, Alba, Canada.
McLean
K
K
Zwiers
H
H
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002148:Calmodulin-Binding Proteins; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D019922:GAP-43 Protein; D007526:Isoelectric Point; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051579:Neurogranin; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D013379:Substrate Specificity
D002148:Calmodulin-Binding Proteins; D019922:GAP-43 Protein; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C496651:Nrgn protein, rat; D051579:Neurogranin; D000246:Adenosine Diphosphate Ribose; D011493:Protein Kinase C