An atypical carcinoid tumor of the lung with mutations in the p53 gene and the retinoblastoma gene.
Molecular analysis of a metastatic lesion of an atypical carcinoid tumor of the lung obtained from a 77-year-old man at autopsy revealed a point mutation in the p53 gene and a deletion in the retinoblastoma (Rb) mRNA. This case suggests that both these antioncogenes may be involved in the progression of atypical carcinoid tumor.
Hiyama
K
K
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Hasegawa
K
K
Ishioka
S
S
Takahashi
N
N
Yamakido
M
M
D000368:Aged; D001483:Base Sequence; D002276:Carcinoid Tumor / Q000235:genetics*; D016161:Genes, Retinoblastoma; D016158:Genes, p53; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction