title: Clinical significance of inpatient family intervention: conclusions from a clinical trial.
abstract: OBJECTIVE
  To test whether the statistically significant results of a randomized clinical trial of an inpatient family intervention were clinically significant for hospital practice, the authors reanalyzed outcome data using a measure of clinical significance based on the extent to which patients had recovered during the course of the intervention.
  
  
  METHODS
  A total of 169 hospitalized subjects and their families were randomly assigned to a psychoeducational inpatient family intervention or to a comparison group. Patient and family outcome measures were assessed at admission, discharge, and six and 18 months after admission. Analyses of statistically significant differences in outcome suggested that inpatient family intervention was effective for certain patient subgroups identified by gender and diagnosis. Global Assessment Scale scores two or more standard deviations above the pretreatment (admission) mean were used as indicators for clinically significant improvement.
  
  
  RESULTS
  The reanalysis confirmed that inpatient family intervention was associated with clinically significant improvement at discharge, especially for female patients and patients with chronic schizophrenia and bipolar disorder. These effects were maintained six months after admission before attenuating at 18 months.
  
  
  CONCLUSIONS
  Inpatient family intervention results in clinically meaningful outcomes for certain subgroups of patients and their families.
authors.affiliation: Payne Whitney Clinic, Cornell University Medical College, New York, New York 10021.
authors.forename: I D
authors.initials: ID
authors.lastname: Glick
authors.forename: J F
authors.initials: JF
authors.lastname: Clarkin
authors.forename: G L
authors.initials: GL
authors.lastname: Haas
authors.forename: J H
authors.initials: JH
authors.lastname: Spencer
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000523:psychology / Q000534:rehabilitation*; D003131:Combined Modality Therapy; D017281:Cost of Illness; D005196:Family Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008297:Male; D010043:Outcome and Process Assessment, Health Care; D010353:Patient Education as Topic; D011618:Psychotic Disorders / Q000523:psychology / Q000534:rehabilitation*; D012559:Schizophrenia / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D012944:Social Support