title: Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling.
abstract: The integrin cytoplasmic domains are generally short amino acid sequences that are highly divergent among alpha-subunits and partially conserved among beta-subunits. Interest in them has increased over the past few years as they have been shown to mediate several kinds of transmembrane signaling events as well as structural connections between the extracellular matrix and the cytoskeleton.
authors.affiliation: Department of Biochemistry, University of Illinois, Urbana 61801.
authors.forename: S K
authors.initials: SK
authors.lastname: Sastry
authors.forename: A F
authors.initials: AF
authors.lastname: Horwitz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion; D002462:Cell Membrane / Q000502:physiology; D003593:Cytoplasm / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000502:physiology*; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D016023:Integrins; D046911:Macromolecular Substances