Armadillos (Dasypus novemcinctus) as a model to test antileprosy vaccines; a preliminary report.
The efficacy of two candidate leprosy vaccines, BCG and a mixture of BCG and killed Mycobacterium leprae, was tested in 62 armadillos caught in the wild. The abilities of the vaccines to convert lepromin-negative armadillos to a positive reaction were compared with a group of control animals. Both vaccines upgraded subsequent lepromin skin-test histopathology. The conversion results parallel the protection values obtained in some BCG vaccine trials against leprosy in humans. Before conducting expensive human trials with new antileprosy vaccines, it would be worthwhile first to evaluate them in the armadillo model.
Job
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CK
Laboratory Research Branch, GWL Hansen's Disease Center, Louisiana State University, Baton Rouge 70894.
Sanchez
R M
RM
Hunt
R
R
Truman
R W
RW
Hastings
R C
RC
D000818:Animals; D001135:Armadillos; D001500:BCG Vaccine / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D005431:Florida; D007916:Lepromin; D007918:Leprosy / Q000517:prevention & control*; D008145:Louisiana; D008297:Male; D009166:Mycobacterium leprae / Q000276:immunology*
D001500:BCG Vaccine; D001428:Bacterial Vaccines; C060596:anti-leprosy vaccine; D007916:Lepromin