[Effect of 6-hydroxydopamine administration to newborn female rats and sex differentiation of the brain].
Remote effects of neonatal 6-hydroxydopamine (6-OHDA) combined with testosterone propionate (TP) and alone were compared to ultrastructure of catecholaminergic terminals of the median eminence and hypothalamic catecholamine (CA) content in the critical period of sexual differentiation of the brain. It is suggested that inability of 6-OHDA to prevent TP-induced anovulatory sterility is connected with the preserved hypothalamic CA levels and a lack of significant degenerative changes in CA-ergic terminals in the median eminence.
Nosenko
N D
ND
Burchinskaia
L F
LF
Reznikov
A G
AG
D000818:Animals; D000831:Animals, Newborn; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012733:Sex Differentiation / Q000187:drug effects*; D012741:Sexual Maturation / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*
D002395:Catecholamines; D013739:Testosterone; D016627:Oxidopamine
Effecty vvedeniia 6-gidroksidofamina novorozhdennym krysiatam-samkam i polovaia differentsiatsiia mozga.