Protective role of propionyl carnitine in vascular disorders experimentally induced by endothelin (ET-1) serotonin and K-carrageenin.
Propionyl carnitine, a derivative of carnitine, has metabolic and cardiovascular effects similar to carnitine but with more pronounced peripheral haemodynamic activity. In these experiments we propose to prove that the administration of propionyl carnitine could prevent the experimental tail thrombosis in the rat induced by endothelin (ET-1), serotonin and K-carrageenin. In this new test of experimental thrombosis, propionyl carnitine was able to reduce the extent of tail thrombosis in a more significant manner than that of carnitine. A possible explanation of this antithrombotic effect of propionyl carnitine is its capacity to counteract the vasoconstrictor activity of endothelin modulating the release of prostanoids induced by endothelin itself.
Bertelli
A
A
Department of Medical Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Giovannini
L
L
Galmozzi
G
G
Bertelli
A A
AA
D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan; D016232:Endothelins; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin; D013623:Tail / Q000098:blood supply; D013927:Thrombosis / Q000517:prevention & control; D014652:Vascular Diseases / Q000139:chemically induced / Q000517:prevention & control*
D002317:Cardiovascular Agents; D016232:Endothelins; C003223:propionylcarnitine; D012701:Serotonin; D002351:Carrageenan; D002331:Carnitine