title: Enhancement of bone formation in rabbits by recombinant human growth hormone.
abstract: We studied the effect of human recombinant growth hormone on diaphyseal bone in 40 adult rabbits. The diaphyseal periosteum of one femur in each animal was mechanically stimulated by a nylon cerclage band. The bands induced an increase in bone formation, bone mineral content, and maximum torque capacity of the diaphyseal bone at 1 and 2 months. Growth hormone enhanced the anabolic effect of the cerclage bands on bone metabolism, evidenced by a further increase in torsional strength of the femurs.
authors.affiliation: Department of Orthopedics, Karolinska Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Ehrnberg
authors.forename: O
authors.initials: O
authors.lastname: Brosjö
authors.forename: P
authors.initials: P
authors.lastname: Låftman
authors.forename: O
authors.initials: O
authors.lastname: Nilsson
authors.forename: L
authors.initials: L
authors.lastname: Strömberg
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone