[Female non-surgical sterilization: use of endo-uterine quinacrine and betamethasone pellets. Review of the subject: experimental bases--pharmacology--toxicology--efficacy].
Quinacrine produces obstruction of the region of the uterine tube by its fibroblastic granulomatous action. Factors such as the Zn++ and Cu++ content of tubal tissue, as well as the use of anti-prostaglandins, potentialise this action. Two groups of patients were evaluated in this study: Group A--95 women. 180 mg of quinacrine +0.6 mg of betamethasone were inserted into the uterine cavity, on the basis of two insertions separated by a one month interval. Two pregnancies were found by the end of the 2nd year, the percentage failure rate being 2.2 and the Pearl index 0.58. Group B--129 women. 216 mg of quinacrine +1.2 mg of betamethasone were inserted into the uterine cavity, on the basis of two insertions separated by a one month interval. Two pregnancies were found by the end of the 1st year, the percentage failure rate being 0.59 and the Pearl index 0.54. Iatrogenic adverse reactions associated with quinacrine only were not seen in either of these two study groups. None of the pregnancies was ectopic.
Zipper
J
J
Universidad de Chile, Facultad de Medicina Norte, Departamento de Fisiologia y Biofisica, Hôpital Sótero del Rio, Santiago.
Rivera
M
M
Dabancens
A
A
D000328:Adult; D000818:Animals; D001623:Betamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D003300:Copper / Q000032:analysis / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D051379:Mice; D011247:Pregnancy; D011796:Quinacrine / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D013245:Sterilization, Reproductive / Q000379:methods*; D017211:Treatment Failure; D014599:Uterus / Q000737:chemistry / Q000187:drug effects; D015032:Zinc / Q000032:analysis / Q000502:physiology
D003300:Copper; D001623:Betamethasone; D011796:Quinacrine; D015032:Zinc
Stérilisation féminine non chirurgicale: utilisation de pellets endo-utérins de quinacrine et bétaméthasone. Révision du sujet: bases expérimentales--pharmacologie--toxicologie--efficacité.