title: Equine pituitary adenoma: a functional and morphological study.
abstract: Clinico-pathological correlations in horses with pituitary adenomas are poorly understood. This paper describes the functional and morphological features of five cases of equine pituitary adenoma and of a case of multinodular pituitary hyperplasia. New findings reported include immunoreactivity for beta-lipotropin (beta-LPH), beta-melanocyte-stimulating hormone (beta-MSH), gamma 3-MSH, prolactin (PRL), and follicle-stimulating hormone (FSH) in neoplastic cells of the pituitary adenoma; and, in the multinodular hyperplasia, beta-LPH, beta-endorphin (beta-END), alpha-MSH, beta-MSH, gamma 3-MSH and FSH immunoreactivity. It is suggested that the equine pituitary syndrome does not correspond to human Cushing's disease, as generally accepted, but is related to the overproduction of several pro-opiomelanocortin (POMC)-derived peptides by the cells of the tumour or hyperplastic nodules.
authors.affiliation: Institute of Animal Pathology, University of Berne, Switzerland.
authors.forename: C E
authors.initials: CE
authors.lastname: Boujon
authors.forename: G E
authors.initials: GE
authors.lastname: Bestetti
authors.forename: H P
authors.initials: HP
authors.lastname: Meier
authors.forename: R
authors.initials: R
authors.lastname: Straub
authors.forename: U
authors.initials: U
authors.lastname: Junker
authors.forename: G L
authors.initials: GL
authors.lastname: Rossi
mesh_terms: D000236:Adenoma / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000302:Adrenal Cortex / Q000473:pathology; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002940:Circadian Rhythm / Q000502:physiology; D003480:Cushing Syndrome; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D006736:Horses; D006801:Humans; D006965:Hyperplasia; D007333:Insulin Resistance; D008297:Male; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000473:pathology*; D010908:Pituitary Hormones, Anterior / Q000032:analysis; D010911:Pituitary Neoplasms / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D011333:Pro-Opiomelanocortin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D010908:Pituitary Hormones, Anterior; D011333:Pro-Opiomelanocortin