title: Development of the adult endocrine pancreas during metamorphosis in the sea lamprey, Petromyzon marinus L. I. Light microscopy and autoradiography.
abstract: The results of this study were found to support the hypothesis put forth by Boenig (Z. Mikrosk-Anat. Forsch., 17:125-184, 1929) that the caudal pancreas of adult lamprey develops from the epithelium of the extrahepatic common bile duct in that the bile duct cells were found to undergo a great proliferation during the early stages of metamorphosis, with a large number of the cells incorporating 3H-thymidine. If the bile duct degenerated as suggested by Barrington (The Biology of Lampreys. Academic Press, London, pp. 135-169, 1972), this uptake would not be expected. The cranial pancreas was determined to develop in a similar manner to the larval islets, with formation of the islets taking place within the intestinal/diverticular epithelium. The newly formed islets would migrate into the surrounding connective tissue. During the later stages of metamorphosis a small number of cells was found to incorporate the tritiated thymidine within mature islets.
authors.affiliation: Department of Zoology, University of Toronto, West Hill, Ontario, Canada.
authors.forename: W M
authors.initials: WM
authors.lastname: Elliott
authors.forename: J H
authors.initials: JH
authors.lastname: Youson
mesh_terms: D000818:Animals; D001345:Autoradiography; D001652:Bile Ducts / Q000254:growth & development; D006651:Histocytochemistry; D007515:Islets of Langerhans / Q000166:cytology / Q000254:growth & development*; D007798:Lampreys / Q000254:growth & development* / Q000378:metabolism; D007814:Larva; D008675:Metamorphosis, Biological; D013936:Thymidine / Q000378:metabolism
chemical_list: D013936:Thymidine