title: Increase of serum growth hormone-binding protein in patients with ossification of the posterior longitudinal ligament of the spine.
abstract: Serum growth hormone-binding protein (GHBP) was measured in 26 patients with ossification of the posterior longitudinal ligament of the spine (OPLL) and 19 age-matched controls. Serum GHBP level was significantly higher in the OPLL group than in the controls, whereas there was no statistical difference between the two groups in serum level of growth hormone, insulin-like growth factor (IGF)-1, and IGF-2. These results, taken together with the hypothesis that serum GHBP reflects the number of GH receptors in tissue, suggest that GH receptors are increased in patients with OPLL.
authors.affiliation: Department of Orthopedics, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ikegawa
authors.forename: T
authors.initials: T
authors.lastname: Kurokawa
authors.forename: N
authors.initials: N
authors.lastname: Hizuka
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: I
authors.initials: I
authors.lastname: Ohnishi
authors.forename: K
authors.initials: K
authors.lastname: Shizume
mesh_terms: D002352:Carrier Proteins / Q000097:blood*; D002574:Cervical Vertebrae; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007335:Insulin-Like Growth Factor II / Q000032:analysis; D007405:Intervertebral Disc Displacement / Q000097:blood; D008297:Male; D008875:Middle Aged; D017887:Ossification of Posterior Longitudinal Ligament / Q000097:blood* / Q000209:etiology; D011986:Receptors, Somatotropin / Q000378:metabolism; D013128:Spinal Osteophytosis / Q000097:blood
chemical_list: D002352:Carrier Proteins; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D013006:Growth Hormone; C051815:somatotropin-binding protein