[Regulation of glycogenolysis against hormones in isolated rat hepatocytes].
cAMP and Ca(2+)-dependent glycogenolytic pathways are regulated by different hormones involved in the activation of glycogen phosphorylase in isolated rat hepatocytes. Dose-dependent glucagon activation of glycogen phosphorylase and lowering of cAMP levels were obtained by vasopressin and angiotensin treatment. Similar time courses of Ca2+ fluxes and phosphorylase activation were induced by vasopressin, angiotensin and phenylephrine. Heterologous down-regulation of hormones was induced in glycogenolysis in hepatocytes. These results could be of significance in physiology studies in vivo.
Chen
W
W
Institute of Oncology, Beijing.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D005934:Glucagon / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D006005:Phosphorylases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D000804:Angiotensin II; D010656:Phenylephrine; D006003:Glycogen; D005934:Glucagon; D000242:Cyclic AMP; D006005:Phosphorylases; D002118:Calcium