title: Thenoyltrifluoracetone induces lipid peroxidation in rat liver mitochondria.
abstract: Addition of thenoyltrifluoracetone to mitochondria oxidizing NAD-dependent substrates induced lipid peroxidation and uncoupling of oxidative phosphorylation. Butylated hydroxytoluene, an antioxidant, prevented accumulation of lipid peroxidation products but failed to prevent deenergization of the mitochondria.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
authors.forename: V
authors.initials: V
authors.lastname: Gogvadze
authors.forename: A
authors.initials: A
authors.lastname: Zhukova
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone / Q000494:pharmacology; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013804:Thenoyltrifluoroacetone / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D002084:Butylated Hydroxytoluene; D013804:Thenoyltrifluoroacetone; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone; D000244:Adenosine Diphosphate