The insulin receptor on activated immunocompetent cells.
This article reviews the corpus of work on the activated T lymphocyte insulin receptor begun in the laboratory of Dr. Reubin Andres. It reviews the pharmacokinetic properties of the lymphocyte insulin receptor and the mechanisms by which the receptor is regulated on the cell. An immunobiologic role for insulin and its receptors is described. Lastly, a novel monokine responsible for fine regulation of the T lymphocyte insulin receptor is described which might be an important immunosuppressant molecule for future studies.
Helderman
J H
JH
Vanderbilt University Medical Center, Division of Nephrology, Nashville, Tennessee 37232-2372.
D006801:Humans; D007328:Insulin / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D011972:Receptor, Insulin / Q000276:immunology / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D007328:Insulin; D011972:Receptor, Insulin