title: Cytotoxicity of Hymenocallis expansa alkaloids.
abstract: From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
authors.forename: M D
authors.initials: MD
authors.lastname: Antoun
authors.forename: N T
authors.initials: NT
authors.lastname: Mendoza
authors.forename: Y R
authors.initials: YR
authors.lastname: Ríos
authors.forename: G R
authors.initials: GR
authors.lastname: Proctor
authors.forename: D B
authors.initials: DB
authors.lastname: Wickramaratne
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D047151:Amaryllidaceae Alkaloids; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D051379:Mice; D010617:Phenanthridines; D010946:Plants, Medicinal / Q000737:chemistry*; D011647:Puerto Rico; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010617:Phenanthridines; C083906:hemanthidine; C060577:hippeastrine; C011361:tazettine