Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant.
We recently encountered a previously healthy 3-year-old girl who had severe bleeding resulting from a severe deficiency of prothrombin. A lupus anticoagulant was identified by several different methods. The patient was successfully treated with glucocorticoids. This rare complication of a lupus anticoagulant should be considered in the differential diagnosis of a previously well child who suddenly has hemorrhage.
Bernini
J C
JC
University of Texas Southwestern Medical Center at Dallas.
Buchanan
G R
GR
Ashcraft
J
J
D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006470:Hemorrhage / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D016682:Lupus Coagulation Inhibitor / Q000097:blood*
D005938:Glucocorticoids; D016682:Lupus Coagulation Inhibitor