title: Differentiation of breast tumors by ultrasonic tissue characterization.
abstract: The ability of ultrasonic tissue characterization to differentiate and classify benign and malignant breast tissues in vivo in patients with palpable breast masses and in vitro in excised breast tissue was evaluated. One-hundred and twenty-four in vivo and 89 in vitro studies were performed using a technique of UTC based on parameters from the power spectrum of backscattered echoes. Sensitivities and specificities for diagnosing carcinoma were 86 and 84% for in vivo studies and 94 and 92% for in vitro studies. These UTC parameters provided threshold values for color-coding breast lesion images. The results of this preliminary investigation suggest that UTC provides a basis for assessing more accurately lesions suspected of being malignant prior to biopsy and possibly for evaluating breast lesions noninvasively.
authors.affiliation: Department of Surgery, Medical College of Pennsylvania, Philadelphia 19129.
authors.forename: R M
authors.initials: RM
authors.lastname: Golub
authors.forename: R E
authors.initials: RE
authors.lastname: Parsons
authors.forename: B
authors.initials: B
authors.lastname: Sigel
authors.forename: E J
authors.initials: EJ
authors.lastname: Feleppa
authors.forename: J
authors.initials: J
authors.lastname: Justin
authors.forename: H A
authors.initials: HA
authors.lastname: Zaren
authors.forename: M
authors.initials: M
authors.lastname: Rorke
authors.forename: J
authors.initials: J
authors.lastname: Sokil-Melgar
authors.forename: H
authors.initials: H
authors.lastname: Kimitsuki
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D005348:Fibrocystic Breast Disease / Q000000981:diagnostic imaging; D006801:Humans; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary