[Effect of intracerebroventricular injection of caerulein on stress-induced gastric mucosal lesion in rats].
The effect of caerulein injected into cerebroventricle on the stress-induced gastric mucosal lesion of rats with tied four limbs immersed in water was investigated. Caerulein (1.0 ng/rat) reduced significantly gastric mucosal lesion, decreased gastric acid content, but increased the gastric content of the mucus and PGE2. Under electromicroscope, morphological sign of hyposecretion in the parietal cells and hypersecretion in the mucus cells could be seen. The effect of caerulein could be prevented by intraventricular injection of naloxone or subcutaneous injection of indomethacin, but not by atropine, phentolamine and propranolol. The results indicate that the protective effect of caerulein on the gastric mucosa is mediated partly by central morphine receptors and partly by enhancement of endogenous PGE2.
Chen
G
G
Department of Physiology, Yanbian Medical College, Yanji.
Jin
Z Z
ZZ
D000818:Animals; D002108:Ceruletide / Q000494:pharmacology* / Q000627:therapeutic use; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology; D013312:Stress, Physiological / Q000150:complications
D011957:Receptors, Opioid; D002108:Ceruletide; D015232:Dinoprostone