Family study of women showing development of antibody to human T-cell leukemia virus I and assessment of the risk of vertical transmission of the virus to their children.
When pregnant women were tested for antibody to human T-cell leukemia virus-I, some were found to be positive although they had been negative during the previous pregnancy. In these women, HTLV-I infection was found from pedigree studies to have been acquired from their mothers rather than from their husbands. Furthermore, some of them had apparently remained HTLV-I antibody-negative for long periods after infection. When the breast-fed children of these women, in whom HTLV-I was acquired from their mothers but who were in an HTLV-I antibody-negative state, were also examined for evidence of HTLV-I infection, none was found.
Ando
Y
Y
Department of Obstetrics and Gynecology, Nara Medical University, Japan.
Tanigawa
T
T
Ekuni
Y
Y
Ichijo
M
M
Tohyama
T
T
D002353:Carrier State / Q000635:transmission*; D005192:Family Health; D005260:Female; D015481:HTLV-I Antibodies / Q000276:immunology*; D015490:HTLV-I Infections / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D010375:Pedigree; D011247:Pregnancy; D012306:Risk
D015481:HTLV-I Antibodies