[Functional properties of tachykinin receptors in the central nervous system].
Three types of tachykinin receptors (NK1, NK2 and NK3) have been identified, their endogenous ligands being substance P, neurokinin A and neurokinin B respectively. Peptide agonists and non peptide antagonists are now available allowing to study the functional properties of these receptors which are coupled to G proteins. Depending on the tissue, stimulations of phospholipase C occur with NK1, NK2 or NK3 agonists. Peptide, a C-terminal substance P analog and substance P(1-7) seem to act on tachykinin receptors distinct from those of the NK1, NK2 or NK3 type. NK2 binding sites have not been visualized in the brain. Nevertheless, biological responses of the NK2 type have been shown both in the substantia nigra and the striatum in studies on dopamine release.
Glowinski
J
J
Laboratoire de Neuropharmacologie, INSERM U114, Collège de France, Paris.
Beaujouan
J C
JC
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D004285:Dogs; D011817:Rabbits; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013045:Species Specificity; D013378:Substantia Nigra / Q000502:physiology; D015320:Tachykinins / Q000037:antagonists & inhibitors / Q000502:physiology*
D017981:Receptors, Neurotransmitter; D015320:Tachykinins
Propriétés fonctionnelles des récepteurs des tachykinines dans le système nerveux central.