title: Antimicrobial treatment for chronic prostatitis as a means of defining the role of Ureaplasma urealyticum.
abstract: A study was conducted to assess the clinical and microbiological effects of antimicrobial treatment for chronic prostatitis as a means of defining the role of Ureaplasma urealyticum. Significant U. urealyticum cells were considered to be isolated from the prostates of 18 of 143 prostatitis patients. These patients with ureaplasma-associated prostatitis were randomly treated with either ofloxacin or minocycline for 2 weeks; 4 patients were excluded due to voluntary withdrawal. U. urealyticum was eradicated in all the patients. Symptoms were resolved in 10 patients, and leukocytes in expressed prostatic secretion were cleared in 4 patients; both drug treatments revealed similar results. Even if we exclude 3 patients with significant coexistent Staphylococcus epidermidis cells before treatment, 3 of 11 patients evaluated showed complete resolution of symptoms and clearance of leukocytes in expressed prostatic fluid. These results suggest that U. urealyticum is a causative organism in some patients with chronic prostatitis.
authors.affiliation: Department of Urology, School of Medicine, Kanazawa University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohkawa
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Tokunaga
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
authors.forename: R
authors.initials: R
authors.lastname: Shoda
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D015242:Ofloxacin / Q000627:therapeutic use*; D011472:Prostatitis / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D016869:Ureaplasma Infections / Q000097:blood / Q000188:drug therapy*; D016990:Ureaplasma urealyticum / Q000302:isolation & purification
chemical_list: D015242:Ofloxacin; D008911:Minocycline