title: [Status of the antioxidant system and sorbitol pathway of glucose metabolism in diabetes mellitus].
abstract: It is found that antioxidative activity (AOA) and activity of glutathione-transferase in postmitochondrial placenta fraction of pregnant women with diabetes mellitus is lowered. Depression of AOA in placenta associated with a decrease of UDA and ceruloplasmin amount in blood of the newborns shows the exhaustion of the antioxidative protection system. A decrease of enzyme activity at the sorbitol way of glucose exchange (sorbitol-dehydrogenase and aldose reductase) in placenta reflects accumulation of sorbitol in tissue, which intensifies the damage of membrane structures in placenta.
authors.forename: A A
authors.initials: AA
authors.lastname: Zakrevskiĭ
authors.forename: L F
authors.initials: LF
authors.lastname: Osinskaia
authors.forename: T K
authors.initials: TK
authors.lastname: Znamenskaia
authors.forename: T V
authors.initials: TV
authors.lastname: Kurilina
authors.forename: L G
authors.initials: LG
authors.lastname: Martynenko
mesh_terms: D000449:Aldehyde Reductase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D010084:Oxidation-Reduction; D010920:Placenta / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D011379:Prognosis; D013012:Sorbitol / Q000378:metabolism*
chemical_list: D013012:Sorbitol; D007064:L-Iditol 2-Dehydrogenase; D000449:Aldehyde Reductase; D002570:Ceruloplasmin; D005982:Glutathione Transferase; D005947:Glucose
vernacular_title: Sostoianie antiokislitel'noĭ sistemy i sorbitolovogo puti metabolizma gliukozy pri sakharnom diabete.