The role of the host during the development of Plasmodium berghei hepatic schizonts.
Immature exoerythrocytic stages of Plasmodium berghei are immunogenic and produce antigens with protective capacities. Immunization experiments show a strong dependency of the responses on the host species and strain. To study this dependency a potential natural host of Plasmodium berghei, Thamnomys gazellae, was introduced, a species which is very susceptible for infection. Young liver stages were produced in different hosts after inoculation with irradiated sporozoites or after treatment with difluoromethylornithine.
François
G
G
Laboratory of Protozoology, Institute for Tropical Medicine, Antwerpen, Belgium.
Wéry
M
M
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D000518:Eflornithine / Q000494:pharmacology; D006790:Host-Parasite Interactions; D007114:Immunization; D008099:Liver / Q000469:parasitology*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology / Q000469:parasitology; D008815:Mice, Inbred Strains / Q000276:immunology / Q000469:parasitology; D009115:Muridae / Q000276:immunology / Q000469:parasitology*; D010962:Plasmodium berghei / Q000187:drug effects / Q000254:growth & development* / Q000276:immunology / Q000528:radiation effects
D000518:Eflornithine