Improved sib-pair linkage test for disease susceptibility loci.
An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful.
Faraway
J J
JJ
Department of Statistics, University of Michigan, Ann Arbor 48109.
D000483:Alleles; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D013223:Statistics as Topic / Q000379:methods
D005819:Genetic Markers