title: Massive allografts sterilised by irradiation. Clinical results.
abstract: From 1984 to 1988 we implanted 127 massive allografts irradiated with a dose of 25,000 grays. These were reviewed at a minimum follow-up of three years to determine the effect of irradiation on infection, the complications and the functional result. No bacteriological infection was seen in the 44 patients who had allografts for revision of joint arthroplasty or for a tumour with no adjuvant therapy. For the 83 patients who also had chemotherapy or radiotherapy or both for a bone tumour, the rate of infection was 13%. The major mechanical complications were nonunion in seven grafts (5.5%) and fracture in eight (6%). These rates do not differ greatly from those reported for non-irradiated grafts. Our results suggest that irradiation, which remains the most convenient and acceptable method of sterilisation, does not jeopardize the clinical results.
authors.affiliation: Henri Mondor Hospital, Créteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Hernigou
authors.forename: G
authors.initials: G
authors.lastname: Delepine
authors.forename: D
authors.initials: D
authors.lastname: Goutallier
authors.forename: A
authors.initials: A
authors.lastname: Julieron
mesh_terms: D000293:Adolescent; D000328:Adult; D001174:Arthrodesis; D001178:Arthroplasty; D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D001859:Bone Neoplasms / Q000401:mortality / Q000601:surgery*; D016025:Bone Transplantation; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D017102:Fracture Healing; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000453:epidemiology; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D011827:Radiation; D011829:Radiation Dosage; D011859:Radiography; D012086:Reoperation; D013242:Sterilization / Q000379:methods*; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000382:microbiology; D015996:Survival Rate; D014184:Transplantation, Homologous; D016896:Treatment Outcome