Serodiagnosis of subacute sclerosing panencephalitis by enzyme linked immunosorbent assay.
Thirty three young patients (23 males and 10 females), between 3-20 years of age, with a clinical suspicion of subacute sclerosing panencephalitis (SSPE) were evaluated over a period of 4 years. A past history of measles was obtained in 42.4% of the cases. One child was immunised against measles. Measles specific antibodies (IgG) were demonstrated in the cerebrospinal fluid (CSF) from 30 (90.9%) of the 33 patients by ELISA. In the remaining three cases the antibodies were detected only in the serum. Serodiagnosis of SSPE by ELISA had a sensitivity of 100%, a specificity of 93.3% and a positive predictive value of 100%.
Lakshmi
V
V
Department of Microbiology, Nizam's Institute of Medical Sciences, Hyderabad.
Malathy
Y
Y
Rao
R R
RR
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008459:Measles virus / Q000276:immunology; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis*
D000914:Antibodies, Viral