title: Myositis in Lyme borreliosis: an immunohistochemical study of seven patients.
abstract: Myositis is a rare complication of Lyme disease. In order to get information about the pathogenesis of this disorder, muscle specimens of 7 patients suffering from myositis as a manifestation of Lyme borreliosis were examined by immunohistology. Lyme spirochetes could be found in muscle biopsies of 6 patients. Infiltrates consisted mainly of macrophages and T helper/inducer cells. The T4/T8 ratio was 1.7 in the endomysium and 2.1 in the perimysium. Increased expression of MHC-I molecules by several muscle fibers was observed in 2 subjects only. No MHC-II molecules were expressed by muscle fibers. Lymphocytes expressing the interleukin-2 receptor were detected in 2 patients. Leu-15+ and Leu-11+ cells were found only to a slight extent in 2 patients. In conclusion the immunohistochemical findings in myositis due to Lyme borreliosis are different from other manifestations of this disease, and also from other forms of myositis.
authors.affiliation: Friedrich-Baur-Institut, Department of Neurology and Internal Medicine, University of Munich, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Müller-Felber
authors.forename: C D
authors.initials: CD
authors.lastname: Reimers
authors.forename: J
authors.initials: J
authors.lastname: de Koning
authors.forename: P
authors.initials: P
authors.lastname: Fischer
authors.forename: A
authors.initials: A
authors.lastname: Pilz
authors.forename: D E
authors.initials: DE
authors.lastname: Pongratz
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D015748:Borrelia burgdorferi Group / Q000276:immunology / Q000378:metabolism; D006680:HLA Antigens / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008193:Lyme Disease / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000276:immunology / Q000648:ultrastructure; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009220:Myositis / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D009410:Nerve Degeneration / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology
chemical_list: D015415:Biomarkers; D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I