title: Raccoon poxvirus rabies virus glycoprotein recombinant vaccine in sheep.
abstract: Twenty sheep were divided into groups and inoculated by various routes with recombinant raccoon poxvirus expressing the CVS rabies virus glycoprotein (rRCNV-G) or with raccoon poxvirus (RCNV). The apparent innocuous pathologic responses to each virus coupled with development of high levels of rabies virus neutralizing antibodies in animals vaccinated with rRCNV-G intradermally or intramuscularly suggested that the recombinant is effective and that RCNV would be a suitable substrate for further development of sheep vaccines. Poor antibody response to rRCNV-G given orally implied that it would be relatively harmless if inadvertently ingested by sheep. Virus transmission between vaccinated and sentinel sheep was not observed or detected serologically.
authors.affiliation: Department of Pathology, Colorado State University, Fort Collins, Colorado.
authors.forename: J C
authors.initials: JC
authors.lastname: DeMartini
authors.forename: H M
authors.initials: HM
authors.lastname: Bickle
authors.forename: S J
authors.initials: SJ
authors.lastname: Brodie
authors.forename: B X
authors.initials: BX
authors.lastname: He
authors.forename: J J
authors.initials: JJ
authors.lastname: Esposito
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology; D000956:Antigens, Viral; D002460:Cell Line; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology*; D009500:Neutralization Tests; D011212:Poxviridae / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D011819:Rabies Vaccines / Q000009:adverse effects / Q000235:genetics / Q000276:immunology*; D011820:Rabies virus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D011821:Raccoons; D012756:Sheep; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D011819:Rabies Vaccines; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; C064951:glycoprotein G, Rabies virus