title: Coronary artery size in mitral regurgitation and its regression after mitral valve surgery.
abstract: The relationship between coronary artery size and left ventricular (LV) muscle mass was studied in 10 control subjects and in 10 patients with chronic mitral regurgitation before and 28 +/- 15 months after mitral valve surgery. Left and right coronary artery size was determined by quantitative coronary arteriography. Left coronary artery size was significantly increased before surgery (26 mm2) and decreased after operation (23 mm2), but was still larger than in control subjects (14 mm2). The right coronary artery was also enlarged preoperatively (13 mm2; controls = 9 mm2), but was normalized after surgery (11 mm2). A linear correlation was found between LV muscle mass and left (r = 0.88, p < 0.001) and right coronary artery size (r = 0.84, p < 0.001) as well as between right coronary artery size and mean pulmonary artery pressure (r = 0.56, p < 0.01). Thus in chronic mitral regurgitation the enlargement of the left and right coronary artery is proportional to the degree of LV hypertrophy. The increase in right coronary artery size is probably the result of right ventricular pressure overload. Postoperatively there is only partial regression of left coronary artery size but normalization of right coronary artery size.
authors.affiliation: Department of Internal Medicine, Cardiology, BPol 11, University Hospital, Zurich.
authors.forename: G
authors.initials: G
authors.lastname: Vassalli
authors.forename: O M
authors.initials: OM
authors.lastname: Hess
authors.forename: O N
authors.initials: ON
authors.lastname: Krogmann
authors.forename: B
authors.initials: B
authors.lastname: Villari
authors.forename: W J
authors.initials: WJ
authors.lastname: Corin
authors.forename: M
authors.initials: M
authors.lastname: Turina
authors.forename: H P
authors.initials: HP
authors.lastname: Krayenbuehl
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology* / Q000503:physiopathology; D006350:Heart Valve Prosthesis; D006801:Humans; D006984:Hypertrophy / Q000209:etiology / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000473:pathology* / Q000601:surgery