Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women.
To study whether balance between antiaggregatory, vasodilatory prostacyclin (PGI2) and proaggregatory, vasoconstrictory thromboxane A2 (TXA2) could be affected by dietary manipulation, 18 pre-eclamptic women were treated in randomized order between 31 and 36 weeks of gestation either with primrose oil (n = 7), with fish oil (n = 5), or with placebo (n = 6). Urinary excretions of the degradation products of PGI2 (6-keto-PGF1 alpha, 2,3-dinor-6-keto-PGF1 alpha) and TXA2 (TXB2, 2,3-dinor-TXB2) were measured in 24 h urines before and serially during the supplementation. Fatty acid supplementation did not affect urinary prostanoid excretions or clinical signs of pre-eclampsia.
Laivuori
H
H
Department of Obstetrics and Gynecology, University of Helsinki, Finland.
Hovatta
O
O
Viinikka
L
L
Ylikorkala
O
O
D011464:Epoprostenol / Q000652:urine*; D005228:Fatty Acids, Essential / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D008041:Linoleic Acids; D031665:Oenothera biennis; D010938:Plant Oils; D011225:Pre-Eclampsia / Q000178:diet therapy* / Q000652:urine; D011247:Pregnancy; D011256:Pregnancy Outcome; D013928:Thromboxane A2 / Q000652:urine*; D017965:gamma-Linolenic Acid
D005228:Fatty Acids, Essential; D005395:Fish Oils; D008041:Linoleic Acids; D010938:Plant Oils; C028498:evening primrose oil; D013928:Thromboxane A2; D017965:gamma-Linolenic Acid; D011464:Epoprostenol