[Clinical and pharmacokinetic observations on fluconazole in the management of cryptococcal meningitis].
The above study was intended to evaluate certain pharmacokinetic properties as well as the pharmacological activity of fluconazole in patients with cryptococcal meningitis. The results obtained show satisfactory bioavailability of the drug in the cerebrospinal fluid and marked reduction of the number of fungi found in the liquor.
Bertucci
R
R
Divisione C Malattie Infettive, USSL TO IV, Ospedale Amedeo di Savoia, Torino.
Leggieri
A
A
Preziosi
C
C
Milano
R
R
Arduino
C
C
Veglio
V
V
D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000382:microbiology*; D000328:Adult; D001682:Biological Availability; D015725:Fluconazole / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000209:etiology
D015725:Fluconazole
Osservazioni cliniche e farmacocinetiche sul fluconazolo nel trattamento della meningite da criptococco.