title: Trinucleotide repeat elongation in the Huntingtin gene in Huntington disease patients from 71 Danish families.
abstract: IT15 is a novel gene, localized to chromosome 4, and encoding a protein named Huntingtin. A polymorphic CAG repeat in the proposed open reading frame of IT15 has been characterized, and an elongation of this repeat has been correlated to Huntington's Disease. We have investigated the CAG repeat in the Huntingtin gene in 71 unrelated Danish patients with Huntington's Disease, and found repeat lengths of 39 to 70 repeat units in contrast to 9 to 30 CAG's on normal chromosomes. Comparison of repeat length and age at onset of disease symptoms in 52 individuals indicates an inverse correlation between the age at onset and the number of CAG repeat units.
authors.affiliation: Institute of Medical Biochemistry and Genetics, University of Copenhagen, Panum Institute, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Nørremølle
authors.forename: O
authors.initials: O
authors.lastname: Riess
authors.forename: J T
authors.initials: JT
authors.lastname: Epplen
authors.forename: K
authors.initials: K
authors.lastname: Fenger
authors.forename: L
authors.initials: L
authors.lastname: Hasholt
authors.forename: S A
authors.initials: SA
authors.lastname: Sørensen
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001483:Base Sequence; D002894:Chromosomes, Human, Pair 4; D017931:DNA Primers / Q000235:genetics; D003718:Denmark; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D009838:Oligodeoxyribonucleotides / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D017931:DNA Primers; C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D009838:Oligodeoxyribonucleotides; D011506:Proteins