Measles virus glycoproteins: studies on the structure and interaction of the haemagglutinin and fusion proteins.
We have investigated the structure and interaction of the measles virus (MV) glycoproteins expressed at the cell membrane. Cross-linking studies with a variety of chemicals stabilized dimeric forms of the haemagglutinin (HA) or fusion (F) proteins, although by sucrose density gradient analysis, oligomers corresponding to tetramers and larger were observed for both proteins. In cells in which both HA and F were expressed at the surface, their close association was shown by cross-linking and co-immunoprecipitation.
Malvoisin
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Institut Pasteur de Lyon, Unité d'Immunologie et Stratégie Vaccinale, France.
Wild
T F
TF
D002499:Centrifugation, Density Gradient; D011232:Chemical Precipitation; D003432:Cross-Linking Reagents; D006023:Glycoproteins / Q000737:chemistry*; D006367:HeLa Cells; D006389:Hemagglutinins, Viral / Q000737:chemistry*; D006801:Humans; D008459:Measles virus / Q000737:chemistry*; D011233:Precipitin Tests; D011994:Recombinant Proteins / Q000737:chemistry; D014760:Viral Fusion Proteins / Q000737:chemistry*; D014764:Viral Proteins / Q000737:chemistry*
D003432:Cross-Linking Reagents; D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D011994:Recombinant Proteins; D014760:Viral Fusion Proteins; D014764:Viral Proteins