title: Fetal biophysical profile score. VI. Correlation with antepartum umbilical venous fetal pH.
abstract: OBJECTIVE
  Our objective was to determine the relationship, if any, between the fetal biophysical profile score and antepartum umbilical venous pH.
  
  
  METHODS
  This was a prospective observational study conducted concurrently in two centers and involving two discrete high-risk groups of fetuses. Fetal biophysical profile scores were compared with umbilical venous pH values measured in blood obtained by immediate cordocentesis. A total of 493 paired observations of biophysical profile score and pH were made; 104 observations were of fetuses with intrauterine growth retardation and 389 observations were of fetuses with alloimmune anemia.
  
  
  RESULTS
  In both data sets there was a highly significant linear correlation between biophysical profile score and umbilical venous pH. Poor biophysical profile score performance (a score of 0 of 10) was always associated with a pH < 7.20, whereas the pH was always > 7.20 when the biophysical profile score was 10 of 10. Sequenced sensitivity of short-term biophysical variables in the detection of acidemia was observed.
  
  
  CONCLUSIONS
  The fetal biophysical profile score accurately predicts antepartum umbilical venous pH.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Winnipeg, Canada.
authors.forename: F A
authors.initials: FA
authors.lastname: Manning
authors.forename: R
authors.initials: R
authors.lastname: Snijders
authors.forename: C R
authors.initials: CR
authors.lastname: Harman
authors.forename: K
authors.initials: K
authors.lastname: Nicolaides
authors.forename: S
authors.initials: S
authors.lastname: Menticoglou
authors.forename: I
authors.initials: I
authors.lastname: Morrison
mesh_terms: D000704:Analysis of Variance; D000743:Anemia, Hemolytic / Q000097:blood*; D055592:Biophysical Phenomena; D001703:Biophysics; D016009:Chi-Square Distribution; D017218:Cordocentesis; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005317:Fetal Growth Retardation / Q000097:blood*; D005324:Fetal Movement; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011237:Predictive Value of Tests; D011247:Pregnancy; D011295:Prenatal Care; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors