Levels of soluble receptors for tumor necrosis factor type I and type II in paired synovial fluids of arthritis patients.
The objective of this study was to determine whether levels of soluble receptors for tumor necrosis factor type I and type II (sTNF-RI and sTNF-RII) as measured in paired synovial fluids (SF) of arthritis patients are associated with clinical or laboratory parameters of local inflammation. sTNF-RI and -RII were measured by ELISA. We found that sTNF-RI and -RII did not correlate with activity of local inflammation. sTNF-RI levels correlated with sTNF-RII concentrations. We concluded that sTNF-RI and -II did not represent markers for local disease activity in arthritis patients.
Miltenburg
A M
AM
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
Aderka
D
D
van Laar
J M
JM
Wallach
D
D
Breedveld
F C
FC
D000328:Adult; D000368:Aged; D001168:Arthritis; D001172:Arthritis, Rheumatoid; D006801:Humans; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis*; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000737:chemistry*
D018124:Receptors, Tumor Necrosis Factor