title: Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard reaction, in diabetic serum.
abstract: 3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic complications such as diabetic nephropathy by promoting the formation of advanced glycation end products.
authors.affiliation: Department of Clinical Laboratory, Nagoya University Branch Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Niwa
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Yoshizumi
authors.forename: A
authors.initials: A
authors.lastname: Tatematsu
authors.forename: M
authors.initials: M
authors.lastname: Ohara
authors.forename: S
authors.initials: S
authors.lastname: Tomiyama
authors.forename: K
authors.initials: K
authors.lastname: Niimura
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003432:Cross-Linking Reagents; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D015416:Maillard Reaction; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D015415:Biomarkers; D003432:Cross-Linking Reagents; C060458:3-deoxyglucose; D003847:Deoxyglucose