Amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis.
Fisher and Lewis rats were amygdala kindled in the morning and in the evening. Fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the Lewis rats. Lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. These observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (HPA) axis, particularly the glucocorticoids, play a role in epileptogenesis.
Weiss
G K
GK
University of New Mexico School of Medicine, Department of Physiology, Albuquerque 87131.
Castillo
N
N
Fernandez
M
M
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D003348:Cortisone / Q000008:administration & dosage / Q000494:pharmacology; D004343:Drug Implants; D004567:Electrodes, Implanted; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007696:Kindling, Neurologic / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew
D004343:Drug Implants; D003346:Corticotropin-Releasing Hormone; D003348:Cortisone