title: Attenuation of the pressor response to tracheal intubation with oral nitrendipine.
abstract: The effect of nitrendipine on the cardiovascular responses to tracheal intubation was studied in a placebo-controlled, randomised, double-blind trial. Thirty patients (ASA physical status 1) undergoing elective surgery received either 5 or 10 mg nitrendipine, or a placebo orally 3 h before induction of anaesthesia (n = 10 for each group). Anaesthesia was induced with sodium thiopentone 5 mg/kg i.v. and tracheal intubation was facilitated with vecuronium 0.2 mg/kg i.v. Patients receiving the placebo showed a significant increase in the mean arterial pressure and the rate-pressure product in response to tracheal intubation. These increases following intubation were reduced in nitrendipine-treated patients compared with the placebo group (P < 0.05). Oral administration of nitrendipine (5 or 10 mg, 3 h before induction of anaesthesia) was able to attenuate the hypertensive response to tracheal intubation in ASA 1 patients under light anaesthesia. We propose this pharmacological technique with supplementary doses of opioids and/or benzodiazepines for the management of patients with hypertension or coronary artery disease.
authors.affiliation: Department of Anaesthesiology, Kobe University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Maekawa
authors.forename: K
authors.initials: K
authors.lastname: Mikawa
authors.forename: K
authors.initials: K
authors.lastname: Nishina
authors.forename: H
authors.initials: H
authors.lastname: Kaetsu
authors.forename: R
authors.initials: R
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Yaku
authors.forename: Y
authors.initials: Y
authors.lastname: Takao
authors.forename: H
authors.initials: H
authors.lastname: Obara
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D009568:Nitrendipine