title: Comparison of intubation following propofol and alfentanil with intubation following thiopentone and suxamethonium.
abstract: We have compared a rapid sequence induction of anaesthesia using propofol 2 mg.kg-1 and alfentanil 50 micrograms.kg-1, with a standard technique using thiopentone 5 mg.kg-1 and suxamethonium 1 mg.kg-1. The incidence of complications, and the quality of conditions for intubation, were similar in both groups. The patients receiving propofol and alfentanil showed a significant decrease in blood pressure and heart rate following induction (p < 0.01), whereas the group receiving thiopentone and suxamethonium showed a significant increase in blood pressure and heart rate following induction (p < 0.01). The use of propofol and alfentanil provided a satisfactory alternative to thiopentone and suxamethonium for a rapid sequence induction of anaesthesia.
authors.affiliation: Department of Anaesthesia, Royal Preston Hospital.
authors.forename: G N
authors.initials: GN
authors.lastname: Beck
authors.forename: G R
authors.initials: GR
authors.lastname: Masterson
authors.forename: J
authors.initials: J
authors.lastname: Richards
authors.forename: P
authors.initials: P
authors.lastname: Bunting
mesh_terms: D000293:Adolescent; D000328:Adult; D015760:Alfentanil / Q000009:adverse effects; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects; D013390:Succinylcholine / Q000009:adverse effects; D013874:Thiopental / Q000009:adverse effects
chemical_list: D015760:Alfentanil; D013390:Succinylcholine; D013874:Thiopental; D015742:Propofol