title: Wide variation in patient response to midazolam sedation for outpatient oral surgery.
abstract: Intravenous midazolam in doses of between 0.07 mg/kg and 0.1 mg/kg has been recommended for sedation in dentistry and some medical procedures and investigations. This study examined the variable sensitivity of patients to midazolam. One hundred and thirty-four fit but anxious patients between the ages of 16 and 63 years received midazolam intravenously for sedation for minor oral surgery. Doses required ranged from 0.04 to 0.40 mg/kg. Nineteen patients required doses less than 0.07 mg/kg; 59 patients required doses greater than 0.1 mg/kg. The mean dose per kilogram required for males was significantly less than for females. The wide variation in sensitivity to midazolam is confirmed.
authors.affiliation: Centre for the Study of Oral Disease, University of Bristol Dental School and Hospital, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Richards
authors.forename: M
authors.initials: M
authors.lastname: Griffiths
authors.forename: C
authors.initials: C
authors.lastname: Scully
mesh_terms: D000293:Adolescent; D000328:Adult; D000556:Ambulatory Surgical Procedures / Q000379:methods; D000766:Anesthesia, Dental / Q000379:methods*; D001047:Apicoectomy; D001835:Body Weight; D016292:Procedural Sedation / Q000379:methods*; D016854:Dental Anxiety / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D008875:Middle Aged; D014081:Tooth Extraction
chemical_list: D008874:Midazolam