Standard heparin and low molecular weight heparin effect on spontaneous platelet aggregation measured in whole blood and in platelet-rich plasma.
The evaluation of both standard heparin (SH) and low molecular weight heparin (LMWH) (Fraxiparine) impact on spontaneous platelet aggregation assessed in the whole blood and in platelet-rich plasma (PRP). The results obtained reveal that SH enhance spontaneous aggregation in a similar degree both in the whole blood (34.5 +/- 3.0, control 21.3 +/- 4.1) and in PRP (33.5 +/- 2.7, control 13.8 +/- 3.2). LMWH significantly intensifies spontaneous aggregation in the whole blood (46.9 +/- 3.2, control 21.3 +/- 4.1) but not in PRP (19.4 +/- 4.3, control 13.8 +/- 3.2).
Komarnicki
M
M
Department of Hematology Academy of Medicine, Poznań.
Kaźmierczak
M
M
Haertle
D
D
D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D017762:Nadroparin / Q000494:pharmacology; D010949:Plasma / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D012016:Reference Values
D017762:Nadroparin; D006493:Heparin