Diffuse cerebral hypoperfusion in epileptic patients observed from quantitative assessment with single photon emission computed tomography using N-isopropyl-(iodine-123)-p-iodoamphetamine.
Quantitative assessment of regional cerebral blood flow (rCBF) in the bilateral cerebral and cerebellar cortices was performed in 15 epileptic adult patients receiving chronic high-dose antiepileptic drug therapy and 22 normal volunteers matched for sex and age, using single photon emission computed tomography with N-isopropyl-(iodine-123)-p-iodoamphetamine. The entire averaged rCBF value in the epileptic patients, i.e. 52.8 +/- 13.7 ml/10 g/min (range: 25-78 ml/100 g/min), was significantly lower as compared with that in the normal subjects, i.e. 69.1 +/- 14.2 ml/100 g/min (range: 46-102 ml/100 g/min). Six of the 15 patients showed absolute rCBF values less than the minimum of the normal range, i.e. 46 ml/100 g/min, in all or most of the measured brain tissues. There was a significant correlation between the diffuse cerebral hypoperfusion and simultaneous ingestion of phenytoin and phenobarbital. The possible effects of antiepileptic drugs on rCBF are discussed.
Jibiki
I
I
Department of Neuropsychiatry, Kanazawa Universtiy School of Medicine, Japan.
Kido
H
H
Matsuda
H
H
Furuta
H
H
Yamaguchi
N
N
Hisada
K
K
D000328:Adult; D000662:Amphetamines; D000927:Anticonvulsants / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon
D000662:Amphetamines; D000927:Anticonvulsants; D020367:Iofetamine