title: Pneumonitis complicating low-dose methotrexate therapy for rheumatoid arthritis. Discrepancies between lung biopsy and bronchoalveolar lavage findings.
abstract: Two very similar cases of drug-induced pneumonitis complicating treatment of rheumatoid arthritis with low-dose methotrexate are presented. Diagnosis was suggested by clinical history and findings, but the bronchoalveolar lavage showed a high percentage of neutrophils, an unusual feature in methotrexate-induced pneumonitis. Transbronchial lung biopsies (TBB) confirmed the diagnosis by showing interstitial lymphocytic infiltrate with microgranulomas. Although histologic findings are not strictly pathognomonic, when a differential diagnosis has to be made with infectious and rheumatoid lung disease, TBB appears to be of great promise.
authors.affiliation: Erasme University Hospital, Chest Department, Brussels, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Leduc
authors.forename: P
authors.initials: P
authors.lastname: De Vuyst
authors.forename: P
authors.initials: P
authors.lastname: Lheureux
authors.forename: P A
authors.initials: PA
authors.lastname: Gevenois
authors.forename: D
authors.initials: D
authors.lastname: Jacobovitz
authors.forename: J C
authors.initials: JC
authors.lastname: Yernault
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D011859:Radiography
chemical_list: D008727:Methotrexate