title: Functional osseointegration of hydroxyapatite-coated implants in a weight-bearing canine model.
abstract: That hydroxyapatite (HA) can form a strong chemical bond with bone has been confirmed by several precedent workers using unloaded implants. The relationship between the histomorphometric measurements of the interface of the cementless femoral stems with and without HA coating and their mechanical properties in a weight-bearing canine model was evaluated in this study. Seven HA-coated and seven uncoated titanium (Ti6Al4V) hemiarthroplasties were implanted in the right hip of 14 dogs for a 5-month period. The specimens were taken to conduct mechanical testing and morphometric measuring. The average interface shear strength of 2.13 MPa for the HA-coated specimens was significantly higher than 0.93 MPa for the uncoated specimens (P < .05). There was greater bone apposition with the HA coating (72.39%) than without the coating (15.96%). Bone interfaces were divided into two types histomorphometrically: type A, simple bony shell without supporting trabeculae and type B, buttressed bony shell with supporting trabeculae. A positive correlation between the type B HA-bone interface and interface shear strength was found (r = .81).
authors.affiliation: Department of Orthopaedic Surgery, University of Toronto, Toronto East General Hospital, Ontario, Canada.
authors.forename: G L
authors.initials: GL
authors.lastname: Maistrelli
authors.forename: N
authors.initials: N
authors.lastname: Mahomed
authors.forename: V
authors.initials: V
authors.lastname: Fornasier
authors.forename: L
authors.initials: L
authors.lastname: Antonelli
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Binnington
mesh_terms: D000497:Alloys; D000818:Animals; D001843:Bone Cements; D004285:Dogs; D017886:Durapatite; D006622:Hip Prosthesis; D016348:Osseointegration / Q000502:physiology*; D013314:Stress, Mechanical; D014025:Titanium; D016474:Weight-Bearing
chemical_list: D000497:Alloys; D001843:Bone Cements; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; D014025:Titanium