title: Ventricular distension and diastolic coronary blood flow in the anaesthetized dog.
abstract: There appears to be no agreement as to whether or not an increase in diastolic left ventricular pressure and/or volume can cause a decrease in diastolic coronary blood flow. We investigated the problem in the anaesthetized dog using a flaccid freely distensible latex balloon inserted into the left ventricle with the animal on extracorporeal circulation and the coronary perfusion pressure constant at about 45 mm Hg. Maximal vasodilatation and suppression of autoregulation in coronary vasculature was obtained by the intracoronary infusion of dipyridamole (10-40 mg/h). Ventricular volume was changed in steps of 10 ml from 10 to 70 ml and back to 10 ml, whilst recording coronary blood flow and left ventricular pressure in the left circumflex coronary artery. Over a range of ventricular volumes from 20 to 50 ml and a concomitant rise in diastolic ventricular pressure to about 20 mm Hg there was no change in the diastolic coronary flow. Only when the ventricular volume was more than two times the control value (i.e. exceeded 50 ml) and left ventricular pressure was more than 20 mm Hg, was there a decrease in coronary flow. During the return of the volume to the control level there was a fall in diastolic flow and ventricular contractility with respect to the values obtained when the volume was increased; these two effects were transient lasting less than 10 min. It was not considered that any of the three models of the coronary circulation, waterfall, intramyocardial pump or varying elastance model could explain our results.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Dipartimento di Anatomia e Fisiologia Umana, Università di Torino, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Gattullo
authors.forename: R J
authors.initials: RJ
authors.lastname: Linden
authors.forename: G
authors.initials: G
authors.lastname: Losano
authors.forename: P
authors.initials: P
authors.lastname: Pagliaro
authors.forename: N
authors.initials: N
authors.lastname: Westerhof
mesh_terms: D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002404:Catheterization; D003326:Coronary Circulation; D003971:Diastole; D004285:Dogs; D016276:Ventricular Function