title: The effects of radiographic contrast media on leucocyte orientation.
abstract: The effects of radiographic contrast media (RCM) on leucocyte orientation in vitro were studied using a Zigmond chamber. Leucocyte orientation was assessed following exposure of the leucocytes to iotrolan, iohexol, ioxaglate and diatrizoate. The RCM used were diluted to a concentration similar to that obtained in vivo during routine angiography. At this concentration there was a significant reduction in leucocyte orientation for all RCM investigated but the effect was more pronounced in the monomeric than the dimeric RCM. The results may have significance when deciding which radiographic contrast medium to use in selected patients, particularly those who are immunosuppressed or septicaemic.
authors.affiliation: Department of Medical Imaging, Derriford Hospital, Plymouth.
authors.forename: C A
authors.initials: CA
authors.lastname: Roobottom
authors.forename: R
authors.initials: R
authors.lastname: Farrow
authors.forename: I P
authors.initials: IP
authors.lastname: Wells
authors.forename: N
authors.initials: N
authors.lastname: Hurlock
mesh_terms: D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology*; D006801:Humans; D007471:Ioglycamic Acid / Q000494:pharmacology*; D007472:Iohexol / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects*; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; C033300:iotrolan; D007472:Iohexol; D007471:Ioglycamic Acid