title: The structure and regulation of tight junctions.
abstract: Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades.
authors.affiliation: Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510.
authors.forename: J M
authors.initials: JM
authors.lastname: Anderson
authors.forename: M S
authors.initials: MS
authors.lastname: Balda
authors.forename: A S
authors.initials: AS
authors.lastname: Fanning
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D007365:Intercellular Junctions / Q000502:physiology* / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000502:physiology; D008954:Models, Biological; D010750:Phosphoproteins / Q000096:biosynthesis / Q000502:physiology; D015398:Signal Transduction; D062826:Zonula Occludens-1 Protein
chemical_list: D008565:Membrane Proteins; D010750:Phosphoproteins; D062826:Zonula Occludens-1 Protein