title: [Neuromeningeal listeriosis in adults. Clinical aspects and contribution of cotrimoxazole in monotherapy].
abstract: A series of 28 patients suffering from neuromeningeal listeriosis is reported. This disease is consecutive to infection by Listeria monocytogenes--an ubiquitous and opportunistic Gram-positive bacillus--and has become a public health problem: its incidence is increasing and its prognosis is very severe despite the development of new bacteriological identification methods. Human beings are contaminated by food, which explains the frequent outbreaks of epidemics which are widely publicized, the infection being one of the consequences of the unprecedented development of the food industry and the cold food chain. The predominant clinical picture is one of non-specific meningoencephalitis. In about 50 percent of the cases the subjects infected are "immunodepressed" and/or more than 60 years' old. The diagnosis is difficult since the bacteriological identification is delayed (direct examination of the cerebrospinal fluid is rarely positive) and this fluid may be sterile (hence the value of blood cultures). A probability treatment therefore must be initiated before the diagnosis is confirmed if an unfavourable outcome is to be avoided. In Listeria monocytogenes infection cotrimoxazole administered alone seems to be a better antibacterial therapy than the reference ampicillin-aminoside combination.
authors.affiliation: Service de Médecine interne et Maladies infectieuses, CHRU de Grenoble.
authors.forename: L
authors.initials: L
authors.lastname: Pinède
authors.forename: G
authors.initials: G
authors.lastname: Manquat
authors.forename: D
authors.initials: D
authors.lastname: Barnoud
authors.forename: J
authors.initials: J
authors.lastname: Croize
authors.forename: M
authors.initials: M
authors.lastname: Guignier
authors.forename: J P
authors.initials: JP
authors.lastname: Stahl
authors.forename: M
authors.initials: M
authors.lastname: Micoud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002511:Cephalosporins / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008584:Meningitis, Listeria / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D008875:Middle Aged; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D002511:Cephalosporins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
vernacular_title: Listériose neuroméningée de l'adulte. Aspects cliniques et apport du cotrimoxazole en monothérapie.