Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2.
Two distinct Id2 cDNA clones, Id2A and Id2B (inhibitor of differentiation), have been isolated from a human heart cDNA library and sequenced. The deduced amino acid sequences show nearly complete identity, except for the nonsense mutation at codon 37 in Id2B. Characterization of the genomic clones revealed that Id2B is encoded by an intronless gene which probably arose after the evolutionary divergence of rats and humans.
Kurabayashi
M
M
Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Jeyaseelan
R
R
Kedes
L
L
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D015139:Blotting, Southern; D003062:Codon; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics*; D018257:Helix-Loop-Helix Motifs / Q000235:genetics*; D006801:Humans; D051797:Inhibitor of Differentiation Protein 2; D007438:Introns; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D012097:Repressor Proteins; D014157:Transcription Factors
D003062:Codon; D004268:DNA-Binding Proteins; C497450:ID2 protein, human; C497451:Id2 protein, rat; D051797:Inhibitor of Differentiation Protein 2; D012097:Repressor Proteins; D014157:Transcription Factors; D004247:DNA