[New views on pathogenesis and treatment of pain caused by nerve injury].
The article focuses on the pathophysiology of pain as a result of injury to the peripheral or central nervous system. The nervous system is dynamic, and nerve injury leads to long-lasting changes in the nociceptive neurons. Plasticity in the neuronal systems regulating nociception is important in explaining clinical features associated with nerve injury pain. To treat nerve injury pain more effectively, measures should be taken to both prevent and reverse the functional neuronal changes and plasticity caused by nerve injury.
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Kirurgisk avdeling, Seksjon Lillestrøm sykehus, Sentralsykehuset i Akershus, Nordbyhagen.
D002490:Central Nervous System / Q000293:injuries* / Q000503:physiopathology; D002908:Chronic Disease; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000209:etiology / Q000503:physiopathology; D059408:Pain Management; D059348:Peripheral Nerve Injuries
Nye synspunkter på patogenesen og behandlingen av smerter ved nerveskade.