title: Synthesis and biological activity of 2-substituted analogues of 2'-deoxy-2'-fluoroadenosine.
abstract: Reaction of 2-iodo-6-methoxypurine 2'-deoxy-2'-fluororiboside with ammonia in methanol gave 2-iodo-adenosine derivative 2 in 69% yield. Treatment of 2 with nucleophiles gave 2-substituted analogues of 2'-deoxy-2'-fluoroadenosine. A new 2'-deoxy-2,2'-difluoroadenosine was also prepared by way of quaternary salt 4.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: K
authors.initials: K
authors.lastname: Utsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003839:Deoxyadenosines / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure
chemical_list: D000998:Antiviral Agents; D003839:Deoxyadenosines; C030964:2'-fluoro-2'-deoxyadenosine