[Dynamic studies of NK activity, IL-2 production and sIL-2R expression in primary hepatic carcinoma patients before and after operation].
The results of a dynamic study of NK activity, IL-2 production and sIL-2R expression before and after operation in 30 primary hepatic carcinoma patients are reported. The NK activity and IL-2 production of patients were significantly lower, sIL-2R expression was remarkably enhanced than those of controls. There was a period of immune suppression after operation. NK activity and IL-2 production of patients with recurrence were significantly lower and sIL-2R expression was significantly enhanced than than those of patients without recurrence. The period of immune suppression in patients with recurrence was longer than that of patients without recurrence. The results suggest that the changes of NK activity, IL-2 production and sIL-2R expression are closely related to the prognosis of patients with primary hepatic carcinoma.
Cao
Y Y
YY
China Medical University, Shenyang.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011184:Postoperative Period; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2