Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion.
To determine whether cocaine-induced deficits in serotonergic function are long-lasting, the neuroendocrine responses to the serotonin (5-hydroxytryptamine, 5-HT) releaser, p-chloroamphetamine were evaluated 1-8 weeks subsequent to 7 days of cocaine exposure (15 mg/kg b.i.d.). In cocaine-pretreated rats, the p-chloroamphetamine-induced elevations of prolactin and renin secretion were significantly reduced for 8 and 4 weeks, respectively. In contrast, the p-chloroamphetamine-induced elevation of adrenocorticotropic hormone (ACTH) secretion was at control values 1 week after cocaine exposure. The data suggest that some cocaine-induced deficits in serotonergic function are long-lasting.
Levy
A D
AD
Department of Pharmacology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153.
Rittenhouse
P A
PA
Bonadonna
A M
AM
Alvarez Sanz
M C
MC
Bethea
C L
CL
Van de Kar
L D
LD
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology*; D013997:Time Factors; D010133:p-Chloroamphetamine / Q000494:pharmacology
D012701:Serotonin; D010133:p-Chloroamphetamine; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D012083:Renin; D003042:Cocaine