Chronic effects of SQ29,852, a new angiotensin converting enzyme (ACE) inhibitor with a phosphonic acid group, in experimental hypertensive rats.
1. Chronic effects on blood pressure of SQ29,852 administered daily for 21 consecutive days were compared to those of captopril and enalapril in spontaneously hypertensive (SHR) and two-kidney-one-clip renal hypertensive (CLIP) rats. 2. SQ29,852 showed significant chronic anti-hypertensive effects at 30 mg/kg in SHR and at 10 mg/kg in CLIP rats. Chronic anti-hypertensive effects of SQ29,852 were in-between those of enalapril and captopril. 3. Significant anti-hypertensive effects lasted in enalapril-treated SHR for 7 days after discontinuation of treatment, while only a tendency toward persistence of anti-hypertensive effects was noted in all animals treated with SQ29,852 and captopril.
Kishi
K
K
Department of Pharmacology, Jichi Medical School, Tochigi-ken, Japan.
Ikeda
M
M
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D004656:Enalapril / Q000494:pharmacology; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D009943:Organophosphorus Compounds; D004656:Enalapril; D011392:Proline; D002216:Captopril; C054518:ceronapril