[Effects of methylflavonolamine on TXA2 and PGI2 plasma levels in rabbits with myocardial infarction].
Effects of methylflavonolamine (MFA) on TXA2 and PGI2 plasma levels in rabbits of myocardial infarction were investigated. It was found that TXB2 levels were inhibited by MFA 2.5 or 5.0 mg.kg-1 i.v. while 6-keto-PGF1 alpha levels were only slightly inhibited after repeated doses of 5.0 mg.kg-1 i.v. within 6 h. This result indicates that MFA exhibit stronger inhibition on cyclo-oxygenase in platelets than in endothelial cells. In addition, the myocardial injury and the size of myocardial infarction were much less in the MFA treated groups than in the control.
Zhang
P
P
Department of Pharmacology, Shanxi Medical College, Taiyuan, China.
Tang
Y Z
YZ
Hao
Y B
YB
Tao
R
R
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood*
D005419:Flavonoids; D044948:Flavonols; D010975:Platelet Aggregation Inhibitors; C052073:SIPI 549; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha