Molecular modelling of tumour-promoting and non-promoting diterpene esters and molecular co-ordinates of the potent irritant resiniferatoxin.
The lowest energy conformer of seventeen diterpenes, representing five different phorbol and daphnane diterpene nuclei, has been generated. TPA possessed the highest minimum free energy of these compounds; all other compounds possessed a lower minimum free energy. Compounds based on the resiniferonol nucleus possessed the lowest minimum free energy (9.4-16.6% of that of TPA). The molecular co-ordinates of the non-promoting but potent irritant resiniferatoxin (Rx) are also reported. These studies may be important in elucidation of the biochemical mechanisms of action of diterpene esters, including an understanding of the interactions of diterpene esters with the phorbol ester binding domain of the protein kinase C isoform family.
Gordge
P C
PC
Department of Pharmacognosy, School of Pharmacy, University of London, UK.
Evans
A T
AT
Ryves
W J
WJ
Sharma
P
P
Hassan
N M
NM
Aitken
A
A
Evans
F J
FJ
D002273:Carcinogens / Q000737:chemistry* / Q000633:toxicity*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003198:Computer Simulation; D004224:Diterpenes / Q000737:chemistry* / Q000633:toxicity*; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D010703:Phorbol Esters / Q000737:chemistry / Q000633:toxicity; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D002273:Carcinogens; D004224:Diterpenes; D010703:Phorbol Esters; C024353:resiniferatoxin