A new visual method for evaluating multiple data (Diagnostic Radar Chart) in general toxicological study.
A Diagnostic Radar Chart method was devised for use in the general assessment of the toxicity of drugs on the basis of visual patterns in toxicity studies. Its usefulness was evaluated on the findings of 32 laboratory items in 3 groups of animal models with experimental pathological conditions. The chart was found to facilitate intuitive discrimination among three types of pathological animal models, evaluation of sexual differences and evaluation of individual differences among the animals for each item. Therefore, if patterns are constructed on the Diagnostic Radar Chart for each of the drugs usable for preparing animal models with typical experimental pathological conditions, the chart is thought to be useful for evaluation or identification of the toxicity of an unknown drug.
Agematsu
Y
Y
Imamichi Institute for Animal Reproduction, Ibaraki, Japan.
Ikarashi
I
I
Furuyama
Y
Y
Kobayashi
N
N
Barada
K
K
Tauchi
K
K
D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D003627:Data Interpretation, Statistical; D005260:Female; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced; D008107:Liver Diseases / Q000097:blood; D008297:Male; D008954:Models, Biological; D051381:Rats; D017208:Rats, Wistar; D014116:Toxicology / Q000379:methods*