Spinal cord motoneurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis.
In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.
Seeburger
J L
JL
Department of Neurology, Hahnemann University, Philadelphia, PA 19102-1192.
Tarras
S
S
Natter
H
H
Springer
J E
JE
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009046:Motor Neurons / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D020917:Receptor, trkA; D017475:Receptors, Nerve Growth Factor / Q000235:genetics*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D020917:Receptor, trkA