Plasmodium falciparum proteinases and red blood cell invasion.
Malarial proteinases of the erythrocytic life-cycle are used to design new inhibitors capable of blocking the parasite's development. The Merozoite Proteinase for Erythrocytic Invasion (MPEI) of Plasmodium falciparum, a neutral proteinase, and the acidic Pf37 proteinase acting on spectrin as substrate, are good candidates for this kind of strategy.
Schrével
J
J
Laboratoire de Biologie Parasitaire et Chimiothérapie, URA CNRS 114, Muséum National d'Histoire Naturelle, Paris, France.
Barrault
C
C
Deguercy
A
A
Grellier
P
P
Lawton
P
P
Heidrich
H G
HG
Caballero
M
M
Monsigny
M
M
Mayer
R
R
D000595:Amino Acid Sequence; D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000469:parasitology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism; D010963:Plasmodium falciparum / Q000201:enzymology* / Q000502:physiology; D015800:Protozoan Proteins / Q000378:metabolism*; D013049:Spectrin / Q000378:metabolism
D010446:Peptide Fragments; D015800:Protozoan Proteins; D013049:Spectrin; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C073894:neutral proteinase Pf105, Plasmodium falciparum; C084242:acidic proteinase Pf37, Plasmodium falciparum