title: Photochemical cleavage of DNA by phosphorus(V) porphyrin derivatives.
abstract: Photocleavages of double-stranded circular DNA and oligonucleotide were investigated by the use of phosphorus(V)tetraphenylporphyrin (P(V)TPP) derivatives. The P(V)TPP derivatives cleaved the DNA and the oligonucleotide under the visible light irradiation, in air and in argon, respectively. It is suggested that the photocleavage reactions include an electron transfer mechanism as well as a singlet oxygen (1O2) one.
authors.affiliation: Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Kitamura
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
authors.forename: H
authors.initials: H
authors.lastname: Segawa
authors.forename: T
authors.initials: T
authors.lastname: Shimidzu
mesh_terms: D010584:Bacteriophage phi X 174 / Q000235:genetics; D001483:Base Sequence; D004279:DNA, Viral / Q000737:chemistry*; D005026:Ethylene Glycols / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D009843:Oligoribonucleotides / Q000737:chemistry*; D010777:Photochemistry; D011166:Porphyrins / Q000737:chemistry*; D017382:Reactive Oxygen Species
chemical_list: D004279:DNA, Viral; D005026:Ethylene Glycols; D009843:Oligoribonucleotides; D011166:Porphyrins; D017382:Reactive Oxygen Species; C084410:bis(hydroxyethyloxy)phosphorus(V)tetraphenylporphyrin; C084411:bis(3'-5'-decathymidylyl)phosphorus(V)tetraphenylporphyrin