Transmission from one child to another of human immunodeficiency virus type 1 with a zidovudine-resistance mutation.
BACKGROUND AND METHODS. We describe a child who apparently acquired human immunodeficiency virus type 1 (HIV-1) infection in the home setting. The suspected source of infection was a child with the acquired immunodeficiency syndrome who had received zidovudine and whose virus contained a mutation associated with in vitro zidovudine resistance. The children were born to different HIV-1-infected mothers, but they lived in the same home between the ages of two and five years. Child 1 was infected perinatally; Child 2 was not and was repeatedly found to be seronegative. Child 2 was examined because of acute lymphadenopathy and had seroconverted to HIV-1 positivity. HIV-1 proviral DNA was amplified from peripheral-blood mononuclear cells and subjected to sequence analysis. Sequences from Child 2 were compared with those from Child 2's mother, Child 1, and local HIV-1-infected control children.
Fitzgibbon
J E
JE
Department of Molecular Genetics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854.
Gaur
S
S
Frenkel
L D
LD
Laraque
F
F
Edlin
B R
BR
Dubin
D T
DT
D001483:Base Sequence; D002675:Child, Preschool; D004279:DNA, Viral; D004351:Drug Resistance / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D015215:Zidovudine / Q000494:pharmacology* / Q000627:therapeutic use
D004279:DNA, Viral; D015215:Zidovudine