Contribution of calcium ions to the generation of epileptic activity and antiepileptic calcium antagonism.
With epileptic activity, neurons show paroxysmal depolarization shifts (PDSs) corresponding to epileptic field potentials (EFPs) generated by the neuronal population. Experimental results indicate that calcium and calcium-dependent currents participate in the generation of these events. Consequently neuronal PDS/EFP were depressed by organic calcium channel blockers. This justifies the hope that calcium channel blockers might be useful in the treatment of human epilepsies.
Speckmann
E J
EJ
Institut für Physiologie, Münster, FRG.
Straub
H
H
Köhling
R
R
D000927:Anticonvulsants / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans
D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D002118:Calcium