Antigenic switching of TSA 417, a trophozoite variable surface protein, following completion of the life cycle of Giardia lamblia.
Expression of TSA 417, the predominant cysteine-rich variable surface protein of Giardia lamblia WB clone C6 trophozoites, did not change during encystation in vitro. However, in vitro excystation of cysts derived in vitro or in vivo consistently produced TSA 417 nonexpressing trophozoite populations, suggesting that completion of the life cycle leads to antigenic switching.
Meng
T C
TC
Department of Medicine, University of California, San Diego Medical Center 92103-8416.
Hetsko
M L
ML
Gillin
F D
FD
D000818:Animals; D000940:Antigenic Variation; D000953:Antigens, Protozoan / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics*; D016829:Giardia lamblia / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D066298:In Vitro Techniques; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; C081832:tsa417 protein, Giardia lamblia