title: Multiple-dose pharmacokinetics of moxisylyte after oral administration to healthy volunteers.
abstract: The pharmacokinetics of moxisylyte in plasma and urine was investigated after oral administration. Twelve subjects were treated orally, twice daily with 240 mg of the drug for 6 days; on day 7, the subjects received a last dose of 240 mg of moxisylyte. Moxisylyte was assayed in plasma and urine by a specific HPLC method with fluorimetric detection. Moxisylyte was absorbed rapidly and changed to its metabolites immediately after drug administration; unchanged moxisylyte was not found in plasma. Two metabolites were found in plasma and urine: conjugated desacetylmoxisylyte (DAM) and the conjugate of desmethylated DAM (MDAM). The pharmacokinetic parameters determined after the first oral administration were not modified on multiple dosing. The apparent elimination half-lives of conjugated DAM and MDAM were 2.3 and 3.5 h, respectively. Elimination of these two metabolites in urine averaged 50 and 10%, respectively.
authors.affiliation: Service d'Urologie-Andrologie, CHU G. Doumergue, Nîmes, France.
authors.forename: P
authors.initials: P
authors.lastname: Costa
authors.forename: F
authors.initials: F
authors.lastname: Bressolle
authors.forename: E
authors.initials: E
authors.lastname: Jarroux
authors.forename: B
authors.initials: B
authors.lastname: Sarrazin
authors.forename: J
authors.initials: J
authors.lastname: Mosser
authors.forename: H
authors.initials: H
authors.lastname: Navratil
authors.forename: M
authors.initials: M
authors.lastname: Galtier
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001711:Biotransformation; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D013948:Moxisylyte / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D013948:Moxisylyte