title: Effect of prepartum propylene glycol administration on periparturient fatty liver in dairy cows.
abstract: Plasma glucose concentration during late gestation was thought to be important for the development of fatty liver near parturition. Thirteen multiparous cows were given a 1-L oral drench of propylene glycol once daily beginning 10 +/- 3.6 d prepartum until parturition. Eleven control cows received a 1-L water drench. Plasma glucose increased following propylene glycol administration. Plasma NEFA concentration was 403 and 234 microM, and plasma insulin concentrations were .354 and .679 ng/ml, for control cows and cows treated with propylene glycol measured from 1 to 7 d prepartum. Plasma NEFA tended to be lower in cows treated with propylene glycol from 1 to 21 d postpartum. Prepartum propylene glycol administration reduced hepatic triglyceride accumulation by 32 and 42% at 1 and 21 d postpartum, respectively. Prepartum plasma BHBA was reduced during propylene glycol administration. Prepartum plasma glucose, NEFA, BHBA, and insulin were strongly correlated with liver triglyceride at 1 d postpartum (r = -.49, .45, .36, and -.49, respectively). Pre- and postpartum DMI were not affected by treatment. Milk production and composition measured through 21 d postpartum were not different between groups.
authors.affiliation: Department of Dairy Science, University of Wisconsin, Madison 53706.
authors.forename: V A
authors.initials: VA
authors.lastname: Studer
authors.forename: R R
authors.initials: RR
authors.lastname: Grummer
authors.forename: S J
authors.initials: SJ
authors.lastname: Bertics
authors.forename: C K
authors.initials: CK
authors.lastname: Reynolds
mesh_terms: D020155:3-Hydroxybutyric Acid; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D005934:Glucagon / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood; D007774:Lactation; D008099:Liver / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000662:veterinary*; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000627:therapeutic use*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007328:Insulin; D011409:Propylene Glycols; D014280:Triglycerides; D019946:Propylene Glycol; D005934:Glucagon; D020155:3-Hydroxybutyric Acid