title: [Linkage analysis in pedigrees with Alzheimer's dementia].
abstract: Linkage analysis with three specific DNA markers was carried out on the Alzheimer's dementia pedigrees. The DNA markers used in our study, D21S1/D21S11, D21S13 and D21S16 in the 21q11.2-21q21 regions are localized. The results from different brain DNA samples and from peripheral blood samples of AD families were evaluated by two-point linkage analysis. The linkage between DNA markers and one AD pedigree was observed (D21S1/S11 and D21S13).
authors.affiliation: Psychiatrické centrum Praha.
authors.forename: I
authors.initials: I
authors.lastname: Mazura
authors.forename: R
authors.initials: R
authors.lastname: Jirák
authors.forename: F
authors.initials: F
authors.lastname: Koukolík
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010375:Pedigree
chemical_list: D005819:Genetic Markers
vernacular_title: Vyuzití vazebné analýzy v rodokmenech s Alzheimerovou demencí.