1-Oleoyl-2-docosahexaenoyl phosphatidylcholine increased paradoxical sleep in F344 rats.
The effects of administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (O-DH-PC), a kind of lecithin, and of glycerophosphorylcholine (GPC) on sleep were investigated in male F344 rats. Intracerebroventricular administration of O-DH-PC at a dose of 10 micrograms/rat induced significant increase in paradoxical sleep time and total sleep time in the following 24 h, while administration of GPC did not. Results suggest that O-DH-PC affects on neuronal mechanism relating to paradoxical sleep, and that the effect of O-DH-PC might be caused by fatty acid residues, rather than choline residue.
Hashimoto
M
M
Department of Physiology, Yamanashi Medical University, Japan.
Gong
X W
XW
Izaki
Y
Y
Iriki
M
M
Hibino
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005997:Glycerylphosphorylcholine / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012895:Sleep, REM / Q000187:drug effects*
D010713:Phosphatidylcholines; D005997:Glycerylphosphorylcholine; C084316:1-oleoyl-2-docosahexaenoyl phosphatidylcholine