[An experimental observation of effect of tetrandrine on pulmonary dysfunction in rabbit model of smoke inhalation injury].
A rabbit model with severe smoke inhalation injury was adopted to observe the effect of tetrandrine, a calcium antagonist, on pulmonary dysfunction after smoke inhalation during 24 hours post injury. It was found that tetrandrine could decrease the permeability of pulmonary and tracheal vascular permeability (p < 0.01), reduce lung edema and improve the function of respiration. These results imply that tetrandrine might be used in the treatment of inhalation injury.
Zhang
M
M
Burn Research Institute, Southwest Hospital, Third Military Medical College, Chongqing.
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D044182:Benzylisoquinolines; D002059:Burns, Inhalation / Q000150:complications / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects; D008297:Male; D011654:Pulmonary Edema / Q000188:drug therapy* / Q000209:etiology; D011817:Rabbits; D012131:Respiratory Insufficiency / Q000517:prevention & control*
D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; C009438:tetrandrine