[Polydatin prevents endotoxin-induced acute lung injury in rats].
The effects of polydatin on endotoxin-induced acute lung injury were studied in rats. The lung injury was induced by infusion of inactivated E. coli 30 min after MPS blockade with red cell membrane. It was found that pretreatment with polydatin resulted in marked reduction of lung wet-to-dry weight ratio, lung permeability index (LPI), neutrophil count in BALF and hemoconcentration. The elevation of lung tissue MDA and the decrease in plasma GSH-Px activity were greatly improved with polydatin. There was significant correlation between LPI and lung MDA level (r = 0.741, P < 0.01). Postmortem examination revealed that polydatin attenuated the histopathological changes. We conclude that polydatin protectsral against endotoxin-induced acute lung injury.
Mo
G Y
GY
Guangzhou Air Force Hospital.
Jin
L J
LJ
Jin
C H
CH
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D005960:Glucosides / Q000302:isolation & purification / Q000627:therapeutic use*; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D013267:Stilbenes / Q000302:isolation & purification / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D005960:Glucosides; D013267:Stilbenes; C058229:polydatin