Influence of dietary taurine on vitamin D absorption.
To evaluate the influence of dietary taurine supplementation on vitamin D absorption, we studied three groups of infants: 21 (11 preterm) were fed a taurine-free formula, 21 (10 preterm) were fed a taurine-supplemented formula (50 mg/100 g of powder) and 20 (9 preterm) were fed human, not heat-treated milk. Taurine, total bile acids, glyco-(GBA) and tauro-(TBA) conjugated bile acids, 25-hydroxyvitamin D3 (25OHD3) and 1,25-dihydroxyvitamin D3 (1,25OH2D3) were determined in all infants at birth in blood cord and at one and three months of life. In preterm infants fed a taurine-free formula, we found lower plasma taurine levels than in infants of other groups at one and three months of life. In these infants, GBA predominated, with a G/T ratio of 1.1 and 1.4 at one and three months of life, whereas in all other infants TBA predominated with a G/T ratio always < 1. Also, 25OHD3 and 1,25OH2D3 levels were significantly lower in preterm infants fed a taurine-free formula than in infants fed a taurine-enriched formula or human milk. Term infants fed a taurine-free formula did not show differences in the parameters studied in comparison to infants of other groups. Low taurine dietary intake appears to compromise vitamin D absorption in preterm infants, and therefore taurine supplementation of preterm infant formulas should be encouraged.
Zamboni
G
G
Pediatric Endocrine Unit, University of Verona, Italy.
Piemonte
G
G
Bolner
A
A
Antoniazzi
F
F
Dall'Agnola
A
A
Messner
H
H
Gambaro
G
G
Tatò
L
L
D001647:Bile Acids and Salts / Q000378:metabolism*; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D006000:Glycocholic Acid / Q000097:blood; D006801:Humans; D007225:Infant Food; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D009753:Nutritive Value; D013654:Taurine / Q000097:blood / Q000494:pharmacology*; D013656:Taurocholic Acid / Q000097:blood; D014807:Vitamin D / Q000378:metabolism*
D001647:Bile Acids and Salts; D014807:Vitamin D; D013654:Taurine; D013656:Taurocholic Acid; D002117:Calcitriol; D006000:Glycocholic Acid; D002112:Calcifediol