[Level of beta endorphins and insulin in blood of obese subjects. Effect of surgical treatment for obesity on higher exchange parameters].
The basal and hyperglycaemia-stimulated secretion of glucose, IRI and beta-endorphin (BE) were studied in subjects who had gone surgical treatment for obesity few years ago and the results were compared with those of obese subjects and lean controls. 58 persons were divided into the following groups: A-obese subjects BMI > 30, B--obese subjects 25 < BMI < 30, C--subjects treated by truncal vagotomy and gastric banding, D--subjects treated by jejunoileostomy, E--control group BMI < 25. Oral glucose (75 g) tolerance test was performed in all subjects. Blood concentration of glucose, and serum concentration of IRI and BE were studied before and 30, 60, 90 and 120 minutes after ingestion of glucose. The basal levels and areas over basal values (AOBV) of investigated parameters were evaluated. Both the basal and glucose stimulated levels of IRI and BE were higher in the obese subjects than in the control group. Truncal vagotomy and gastric banding or jejunoileostomy resulted in reduction of IRI secretion without any decrease in BE levels. The alteration of the opioid system may play some role in the pathogenesis of obesity.
Twardowska-Saucha
K
K
Klinika Chorób Wewnetrznych i Zawodowych Slaskiej Akademii Medycznej, Zabrzu.
Pardela
M
M
Grzeszczak
W
W
Lacka
B
B
D000328:Adult; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007581:Jejunoileal Bypass; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D012016:Reference Values; D015167:Vagotomy, Truncal; D001615:beta-Endorphin / Q000097:blood*
D007328:Insulin; D001615:beta-Endorphin
Stezenie beta-endorfiny i insuliny we krwi u otyłych. Wpływ leczenia operacyjnego otyłości na wyzej wymienione parametry.