title: Protective effect of SV-IV on platelet-activating factor-induced hypotension, bronchoconstriction and gastric mucosal injury.
abstract: The inhibitory effect of one of the major proteins secreted by the rat seminal vesicles (SV-IV) on platelet-activating factor (PAF)-induced biological activities was investigated in vivo. SV-IV was found to prevent dose dependently both hypotension and acute bronchospasm caused by PAF administration in guinea-pigs. In addition, SV-IV inhibited both PAF- and ethanol-induced gastric mucosal injury in a dose-dependent manner.
authors.affiliation: Department of Experimental Pharmacology, University of Naples Federico II, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Persico
authors.forename: S
authors.initials: S
authors.lastname: Metafora
authors.forename: F
authors.initials: F
authors.lastname: Mancuso
authors.forename: A
authors.initials: A
authors.lastname: Calignano
authors.forename: A
authors.initials: A
authors.lastname: Venturelli
authors.forename: L
authors.initials: L
authors.lastname: Mariniello
authors.forename: R
authors.initials: R
authors.lastname: Porta
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D016084:Bronchoconstriction / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D006168:Guinea Pigs; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D029589:Seminal Plasma Proteins; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000897:Anti-Ulcer Agents; D010972:Platelet Activating Factor; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; D000431:Ethanol