[Angiotensin converting enzyme (ACE) in scalded rats and protective effect of chloroquine (CQ) in lung injury].
Wistar rats were scalded and then divided at random into control group and scalded+CQ group. They were sacrificed in lots at 6, 24 and 48 hours after the scald and blood was drawn for the determination of ACE, PLAa, Pa02. Pathological examination was also done. The results revealed that, 1. after scald, the rat's serum ACE was reduced below normal value, and it occurred before changes in blood gas, suggesting that ACE might be used as a valuable supplementary diagnostic criterion for pulmonary failure; 2. CQ provided certain amount of protection in pulmonary failure of scalded rat.
Xue
L B
LB
Trauma Center, Postgraduate Medicai College of PLA, 304th Hospital of PLA, Beijing.
D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000201:enzymology*; D002738:Chloroquine / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011654:Pulmonary Edema / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D002738:Chloroquine; D007703:Peptidyl-Dipeptidase A