Suppressing effect of Lactobacillus casei administration on the urinary mutagenicity arising from ingestion of fried ground beef in the human.
It is known that the ingestion of cooked meat which contains carcinogenic heterocyclic amines causes increase in urinary mutagenicity in humans. Using 6 healthy non-smokers, we examined the effect of 3-week oral administration of Lactobacillus casei (bacilli commonly present in yoghurt), on the urinary mutagenicity derived from ingestion of fried ground beef. Comparison of the urinary mutagenicity found before and after the L. casei treatment showed that the treatment resulted in a decrease (6-67%, average 47.5%) of the mutagenicity. This suppressing effect is possibly related to the changes in the intestinal microflora population.
Hayatsu
H
H
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Hayatsu
T
T
D000328:Adult; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens / Q000633:toxicity*; D003296:Cooking; D005260:Female; D006801:Humans; D007780:Lacticaseibacillus casei; D008297:Male; D008460:Meat; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000032:analysis*; D011208:Powders / Q000008:administration & dosage; D014556:Urine / Q000737:chemistry*
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D009153:Mutagens; D011208:Powders