title: Hematotoxicity of 5-fluorouracil and alpha-interferon on the human normal hemopoietic progenitors.
abstract: The toxic effects of a combination of 5 fluorouracil (5-FU) and interferon alpha on normal human hemopoietic progenitors were assessed in vitro. CFU-GM growth was evaluated following 1 h incubation of bone marrow cell suspension with 5-FU 100 micrograms/ml or IFN-alpha 2a 1000 U/ml, or with both drugs, either simultaneously or sequentially added. IFN-alpha did not show toxic effects on normal human hemopoietic progenitors and the severe toxicity of 5-FU on the latter was not modified by IFN-alpha. These results suggest that the changes observed in vivo of 5-FU toxicity induced by IFN-alpha should be attributed to indirect effects of the latter.
authors.affiliation: Department of Internal Medicine, University of Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Castello
authors.forename: M
authors.initials: M
authors.lastname: Mencoboni
authors.forename: R
authors.initials: R
authors.lastname: Lerza
authors.forename: G
authors.initials: G
authors.lastname: Bogliolo
authors.forename: I
authors.initials: I
authors.lastname: Pannacciulli
mesh_terms: D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000633:toxicity*; D006098:Granulocytes / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000633:toxicity*; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D005472:Fluorouracil