[The stimulatory effect of dorsal vagal complex injection of pentagastrin on gastric motility in rats].
Changes in antral motility induced by pentagastrin (G5) microinjected into the dorsal vagal complex (DVC) were investigated in fasting conscious rats. Antral motility was monitored by using chronically implanted force transducer sutured to the antrum. DVC injection of G5 markedly stimulated the amplitude of gastric contraction in a dose-dependent manner. The effect, being rapid in onset and long lasting, could not be mimicked by intravenous administration of G5 but could be markedly inhibited by microinjection of antigastrin serum into DVC. Atropine (100 micrograms.kg-1.h-1) and vagotomy could also abolish the G5 induced antral motility. No significant changes in plasma motilin were observed in portal venous blood after administration of G5 in DVC. These results suggested that DVC is an important site of action for G5 induced stimulation of gastric contraction as mediated by vagal cholinergic pathway.
Zhang
R
R
Department of Physiology, Chinese Academy of Medical Sciences, Beijing.
Zhou
L
L
Zhang
B Z
BZ
D000818:Animals; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D009037:Motilin / Q000097:blood; D010418:Pentagastrin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology
D009037:Motilin; D010418:Pentagastrin