Differential action of phenytoin and carbamazepine on cortical interhemispheric responses in young but not in adult rats.
Single as well as paired responses to stimulation of the contralateral sensorimotor cortex were recorded in adult and 12-day-old rats under urethane anesthesia. Carbamazepine (50 mg/kg i.p.) prolonged the peak latencies of single responses in both adult and young rats, while phenytoin (60 mg/kg i.p.) prolonged the latencies in adult animals but shortened them in the young ones. Excitability cycles of the amplitude of the initial positive-negative complex remained uninfluenced by either drug in both age groups. Since solvent alone did not induce any effects in either test, our results demonstrate a qualitative change in the action of phenytoin during development.
Mares
P
P
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Seidl
J
J
Nováková
J
J
D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology*; D004558:Electric Stimulation; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D010433:Pentylenetetrazole; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*
D002220:Carbamazepine; D010672:Phenytoin; D010433:Pentylenetetrazole