Elevated basal AP-1 DNA binding activity in developing rat brain.
Nuclear extracts from hippocampi, striata and hypothalami of postnatal day (P) 7 rats contained elevated basal levels of AP-1 DNA binding activity and c-jun protein, which decreased to the low basal levels observed in the adult by P21. In contrast to the AP-1 DNA binding complex in the adult brain, the fos-related antigens were not a major component of the P7 AP-1 DNA binding activity.
Pennypacker
K R
KR
Neuropharmacology Section Laboratory of Integrative Biology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709.
Dreyer
D
D
Hong
J S
JS
McMillian
M K
MK
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D003342:Corpus Striatum / Q000254:growth & development / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*; D016758:Genes, jun; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism; D007031:Hypothalamus / Q000254:growth & development / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D004268:DNA-Binding Proteins; D015345:Oligonucleotide Probes; D016755:Proto-Oncogene Proteins c-jun