Distribution of radiolabeled cis-diamminedichloroplatinum (II) on scintigraphic images in the tumor-bearing rabbit.
To evaluate the feasibility of using scintigraphic images to assess the distribution of cis-diamminedichloroplatinum (II) (CDDP), we obtained serial scintigraphic images using radiolabeled CDDP (Pt-195m CDDP), which had high specific activity (7.4 x 10(6) Bq [200 microCi]/mg-CDDP) in the rabbit VX-2 tumor system. Radioactivity at the heart decreased in a biexponential manner, with an initial half-time of 15.3 min and secondary phase of 4.5 days. Time-activity curves revealed that the tumor/heart ratio was greater than 1.0 (1.0-1.1) between 30 min and 4 hr after intravenous injection. The scintigraphic study clearly depicted the tumor. Pt-195m CDDP uptake by the rabbit tumor at 2 hr was 7.8% of the total injected dose. These data suggest that scintigraphic imaging using Pt-195m CDDP is a promising method for imaging tumors and evaluating their CDDP uptake.
Kataoka
M
M
Department of Radiology, Ehime University School of Medicine, Japan.
Kawamura
M
M
Nishiyama
Y
Y
Fujii
T
T
Mogami
H
H
Itoh
H
H
Akuta
K
K
Akaboshi
M
M
Kawai
K
K
Hamamoto
K
K
D000818:Animals; D002945:Cisplatin / Q000493:pharmacokinetics*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D010984:Platinum; D011817:Rabbits; D011868:Radioisotopes; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D011868:Radioisotopes; D010984:Platinum; D002945:Cisplatin