Multiple pathogens may induce growth factor cascade resulting in KS.
While lipopolysaccharide endotoxin is the most prominent inducer of the kinecascade (TNF alpha, IL-1, 4, 6, 8) that leads to shock and multiple organ failure, bacterial exotoxins and products of certain gram positive bacteria can induce the same end results. We theorize that more than one pathogen can induce the sequence of protooncogene activation and growth factor release that results in the formation of KS. If KS has its own unique viral etiology, this virus has not as yet been isolated or identified but we continue to search for it. However, it is entirely possible that these lesions do not have a single well-defined etiologic agent but are the result of multiple agents cooperating in a set sequence. An endogenous, or apathogenic exogenous, retrovirus may replace HIV for initiator growth factor induction in CD4 cells in the classical (Mediterranean) or iatrogenic disease; and other pathogens co-exist or sequentially replace each other in the African endemic disease; whereas an array of viral pathogens (prominent among them CMV) take over growth factor induction in endothelial cells proliferating in response to the initiator growth factor (oncostatin M) released from HIV-infected CD4 lymphocytes in AIDS-KS.
Sinkovics
J G
JG
Cancer Inst., St. Joseph's Hospital, Tampa, FL.
Szakacs
J E
JE
Gyorkey
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018407:Bacterial Physiological Phenomena; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D012514:Sarcoma, Kaposi / Q000382:microbiology* / Q000473:pathology*; D018406:Virus Physiological Phenomena
D006133:Growth Substances