[Interaction of cefotaxime and normal human serum in the bacteriocidal process against strains of Escherichia coli producing surface K1 antigen].
A comparison was made regarding susceptibility of strains of E. coli to bactericidal activity of normal human serum. It was found that when among strains with K1 antigen over 40% were resistant to normal human serum, strains without this antigen were resistant in only 15%. Sub-doses of cefotaxime (1/2 and 1/3 MIC) together with normal human serum strong bactericidal action against strains of K1-possessing E. coli resistant to serum. Sub-doses of cefotaxime cause occurrence of elongated form of bacteria, starting one hour after addition of the antibiotic. Elongated forms of bacteria are not loosing antigen K1 and this suggest that it probably does not exert a role in protection of bacteria against synergistic action of both studied factors.
Franiczek
R
R
Katedra i Zakład Mikrobiologii Akademii Medycznej, Wrocławiu.
Jankowski
S
S
D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D001769:Blood / Q000276:immunology*; D002439:Cefotaxime / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D012016:Reference Values; D013045:Species Specificity
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D002439:Cefotaxime
Współdziałanie cefotaksymu i normalnej surowicy ludzkiej w procesie bakteriobójczym wobec pałeczek Escherichia coli wytwarzajacych powierzchniowy antygen K1.