Metabolism of beta-muricholic acid in the hamster and prairie dog.
The metabolism of beta-muricholic acid was investigated in the prairie dog and the hamster. Intravenous infusion into bile fistula hamsters showed that beta-muricholic acid was extracted by the liver and secreted into the bile (> 85% in 1 h). Hepatic extraction of this compound and cholic acid in the prairie dog was not as rapid as in the hamster. In the bile of the prairie dog, most (93%) of the administered beta-muricholic acid was present as the taurine conjugate. In the hamster, 28% of infused beta-muricholic acid was secreted in unconjugated form, 43% as the taurine conjugate, and 22% as the glycine conjugate. In both species, the administered compound underwent little biotransformation. After intraduodenal injection of [6 alpha-3H]-labeled beta-muricholic acid into bile fistula hamsters, the bile acid was rapidly secreted into the bile; more than 80% of the administered radioactivity was recovered in 3 h. In the prairie dog, biliary recovery after intraduodenal administration of either beta-muricholic acid (43% in 3 h) or cholic acid (22% in 3 h) was slower than in the hamster. After intragastric administration, more than 80% of beta-muricholic acid was recovered unchanged in feces of both animal species.
Miki
S
S
Department of Surgery, Beth Israel Medical Center, New York, NY 10003.
Mosbach
E H
EH
Cohen
B I
BI
Mikami
T
T
Infante
R
R
Ayyad
N
N
McSherry
C K
CK
D000818:Animals; D001646:Bile / Q000378:metabolism; D001894:Borohydrides; D019826:Cholic Acid; D002793:Cholic Acids / Q000378:metabolism*; D006224:Cricetinae; D005243:Feces; D005998:Glycine / Q000378:metabolism; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism; D008297:Male; D008647:Mesocricetus / Q000378:metabolism*; D012589:Sciuridae / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism; D014316:Tritium
D001894:Borohydrides; D002793:Cholic Acids; D014316:Tritium; D013654:Taurine; C004821:muricholic acid; C025364:sodium borohydride; D019826:Cholic Acid; D005998:Glycine