Molecular approaches for the treatment of hemorrhagic fever virus infections.
Viruses causing hemorrhagic fevers in man belong to the following virus groups: togavirus (Chikungunya), flavivirus (dengue, yellow fever, Kyasanur Forest disease, Omsk hemorrhagic fever), arenavirus (Argentinian hemorrhagic fever, Bolivian hemorrhagic fever, Lassa fever), filovirus (Ebola, Marburg), phlebovirus (Rift Valley fever), nairovirus (Crimian-Congo hemorrhagic fever) and hantavirus (hemorrhagic fever with renal syndrome, nephropathic epidemia). Hemorrhagic fever virus infections can be approached by different therapeutic strategies: (i) vaccination; (ii) administration of high-titered antibodies; and (iii) treatment with antiviral drugs. Depending on the molecular target of their interaction, antiviral agents could be classified as follows: IMP dehydrogenase inhibitors (i.e., ribavirin and its derivatives); OMP decarboxylase inhibitors (i.e., pyrazofurin); CTP synthetase inhibitors (i.e., cyclopentylcytosine and cyclopentenylcytosine); SAH hydrolase inhibitors (i.e., neplanocin A); polyanionic substances (i.e., sulfated polymers); interferon and immunomodulators.
Andrei
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Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
De Clercq
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D000998:Antiviral Agents / Q000627:therapeutic use*; D018050:Arenavirus; D002240:Carbohydrate Sequence; D016563:Filoviridae; D005416:Flavivirus; D006476:Orthohantavirus; D006482:Hemorrhagic Fevers, Viral / Q000188:drug therapy* / Q000382:microbiology* / Q000635:transmission; D006801:Humans; D008969:Molecular Sequence Data; D016855:Nairovirus; D014035:Togaviridae
D000998:Antiviral Agents