Striatal [18F]dopa uptake in familial idiopathic dystonia.
It is known that most cases of idiopathic torsion dystonia (ITD) are inherited in an autosomal dominant fashion. Despite clarification of the underlying genetic defect, no consistent structural lesion has been identified in ITD, and it is probable that a biochemical disturbance is the basis of the disorder. To determine whether there is impaired function of the nigro-striatal dopaminergic terminals in ITD we studied 11 subjects with generalized ITD and a positive family history using [18F]dopa and PET scanning. Of these 11 patients, eight had putamen [18F]dopa uptake within the lower half of the normal range, while three had uptake reduced by > 2 SDs below the normal mean. The lowest putamen [18F]dopa influx constants were found in the most disabled patients. As these reductions were mild it is unlikely that abnormalities of the nigro-striatal dopaminergic pathway are the primary determinant of either the nature of the severity of dystonic symptoms. In addition, we studied three presumed carriers of the ITD gene. These subjects all had normal striatal [18F]dopa influx constants suggesting that [18F]dopa PET is unsuitable as a screening tool for ITD.
Playford
E D
ED
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Fletcher
N A
NA
Sawle
G V
GV
Marsden
C D
CD
Brooks
D J
DJ
D000328:Adult; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000493:pharmacokinetics*; D004422:Dystonia Musculorum Deformans / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
D005462:Fluorine Radioisotopes; D004295:Dihydroxyphenylalanine