title: Malaria transmission-blocking activity in the plasma of Plasmodium falciparum gametocyte carriers in Cameroon.
abstract: Experimental infections of Anopheles gambiae were carried out with Plasmodium falciparum gametocytes from 65 naturally infected patients in Cameroon. A comparison was made between infections with blood containing autologous plasma and blood in which the plasma was replaced by plasma from donors without previous malaria exposure. A lower mosquito-infection rate was observed in 50 out of 65 autologous plasma samples. The transmission was completely blocked in 8 infections, whilst belonging exposures to heterologous plasma led to infected mosquitoes. Evidence is shown that blood plasma factors of gametocyte carriers from a population living in a malaria-endemic area are able to reduce transmission capacity.
authors.affiliation: University of Nijmegen, Department of Medical Parasitology, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Mulder
authors.forename: T
authors.initials: T
authors.lastname: Tchuinkam
authors.forename: J P
authors.initials: JP
authors.lastname: Verhave
authors.forename: V
authors.initials: V
authors.lastname: Robert
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D002163:Cameroon; D002353:Carrier State / Q000097:blood* / Q000469:parasitology; D002648:Child; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000097:blood* / Q000469:parasitology / Q000635:transmission; D010963:Plasmodium falciparum / Q000254:growth & development / Q000302:isolation & purification*; D012098:Reproduction