title: Immunoassay reagents for psychoactive drugs. Part 3. Removal of phenothiazine interferences in the quantification of tricyclic antidepressants.
abstract: Phenothiazines and their metabolites are known to interfere in the quantification of tricyclic antidepressants (TCAs). A method for selective chemical modification of phenothiazines by chloramine-T in the presence of TCAs is described. This method allows for accurate quantification of the TCA analyte in a serum sample without interference from the modified phenothiazine.
authors.affiliation: Abbott Laboratories D-9NM, Abbott Park, IL 60064.
authors.forename: M
authors.initials: M
authors.lastname: Adamczyk
authors.forename: J R
authors.initials: JR
authors.lastname: Fishpaugh
authors.forename: C A
authors.initials: CA
authors.lastname: Harrington
authors.forename: D E
authors.initials: DE
authors.lastname: Hartter
authors.forename: R E
authors.initials: RE
authors.lastname: Hruska
authors.forename: A S
authors.initials: AS
authors.lastname: Vanderbilt
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000032:analysis / Q000097:blood*; D002700:Chloramines; D002746:Chlorpromazine / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions; D006801:Humans; D007118:Immunoassay; D008954:Models, Biological; D010084:Oxidation-Reduction; D010640:Phenothiazines / Q000032:analysis / Q000097:blood*; D011619:Psychotropic Drugs / Q000032:analysis / Q000097:blood*; D014105:Tosyl Compounds
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002700:Chloramines; D010640:Phenothiazines; D011619:Psychotropic Drugs; D014105:Tosyl Compounds; C016300:chloramine-T; C031637:phenothiazine; D002746:Chlorpromazine