Autoradiographic localisation of NMDA binding sites in brainstem cardiorespiratory areas of adult and newborn cats.
Quantitative autoradiography was used to determine the distribution of [3H]1-[1-(2-thienyl)cyclohexyl] piperidine ([3H]TCP) binding sites in the brainstem in order to localize the possible targets activated by excitatory amino acids in adult and newborn cats during autonomic rhythmic functions. Medium to high densities of binding sites were found in the nucleus tractus solitarius complex and the laterodorsal part of the pontine tegmentum. In the kitten, there was an apparent higher density in cranial motor nuclei proximal to these structures. It is concluded that there is an overlapping between the high density of NMDA receptors and the localization of cardiorespiratory neurons in cat as well as in kitten.
Salès
N
N
INSERM U334, SHFJ, DRIPP, CEA, Hôpital d'Orsay, France.
Ghilini
G
G
Denavit-Saubié
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography / Q000379:methods; D001665:Binding Sites; D001931:Brain Mapping; D001933:Brain Stem / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D002415:Cats; D013287:Illicit Drugs; D008564:Membrane Potentials; D016202:N-Methylaspartate / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000378:metabolism; D011149:Pons / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis / Q000378:metabolism*; D014316:Tritium
D013287:Illicit Drugs; D016194:Receptors, N-Methyl-D-Aspartate; D014316:Tritium; D016202:N-Methylaspartate; C012058:tenocyclidine; D010622:Phencyclidine