[Some problems of TS measurement after administration of fluoropyrimidines in colorectal cancer. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma].
A joint multicenter comparative study of carmofur (HCFU) alone or HCFU+dipyridamole (DP) concurrent administration was conducted by the Kinki Colorectal Cancer Chemotherapy Society. In this study, the drugs were administered five days prior to surgery, and thymidylate synthetase (TS) inhibition rate at the primary lesion of colorectal cancer was determined. In addition, the effect of time after resection of the primary lesion before specimen cooling on the TS inhibition rate was investigated. The subjects were 87 registered patients who received colorectal cancer surgery during 4 months from October 1991 to January 1992. The time before postsurgical cooling was divided into four group; within 10 min (n = 67), 11-20 min (n = 8), 21-30 min (n = 7), and 31 min or longer (n = 5). The TS inhibition rates (mean +/- SD) were 0.45 +/- 0.22, 0.38 +/- 0.19, 0.30 +/- 0.21, and 0.04 +/- 0.05 respectively. The longer the time after resection of the primary lesion before specimen cooling, the more TS inhibition rate decreased. When the time before specimen cooling exceeds 30 min, the major part of TS combined with FdUMP exists in a free state. Therefore, it was considered not suitable as the material for the measurement.
Kameyama
M
M
Dept. of Surgery, Center of Adult Diseases, Osaka.
Nakamori
S
S
Imaoka
S
S
Utsunomiya
J
J
Oshima
A
A
Kikkawa
N
N
Hioki
K
K
Fukuda
I
I
Mori
T
T
Yasutomi
M
M
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D004176:Dipyridamole / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D004176:Dipyridamole; D013940:Thymidylate Synthase; C017367:carmofur; D005472:Fluorouracil