Comprehensive delineation of antigenic and immunogenic properties of peptides derived from the nef HIV-1 regulatory protein.
The Human Immunodeficiency Virus (HIV-1) nef regulatory protein, a protein involved in AIDS pathology, was used as a model to investigate and analyze B- and T-cell epitopes. In this paper, we describe the potential structural basis of antigenic and immunogenic reactivity of synthetic peptides derived from the macromolecular antigen. The relationship between B- and T-cell determinants in the context of regulatory mechanisms involved in immune recognition, while integrating recent data concerning MHC presentation. As a result of the recent progress in the field of peptide recognition and presentation, the potential of the peptide approach for constructing successful synthetic vaccines needs to be continuously re-evaluated.
Estaquier
J
J
Centre d'Immunologie des Maladies Transmissibles et Allergiques, Unité mixte Inserm U 167-CNRS 624, Institut Pasteur, Lille, France.
Boutillon
C
C
Gras-Masse
H
H
Ameisen
J C
JC
Capron
A
A
Tartar
A
A
Auriault
C
C
D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000276:immunology*; D015693:Gene Products, nef / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology*; D054311:nef Gene Products, Human Immunodeficiency Virus
D000956:Antigens, Viral; D015693:Gene Products, nef; D010446:Peptide Fragments; D054311:nef Gene Products, Human Immunodeficiency Virus