title: [Postoperative respiratory function and cholecystectomy by laparoscopic approach].
abstract: Open cholecystectomy is associated with characteristic changes in pulmonary function showing a restrictive pattern. Laparoscopic cholecystectomy without opening of the peritoneal cavity could be an alternative in reducing postoperative respiratory dysfunction. Having given their informed consent, 13 healthy ASA1 patients (age: 41 +/- 18 yrs) undergoing laparoscopic cholecystectomy were enrolled in this study, in order to assess their postoperative pulmonary function tests (forced vital capacity [FRC], forced expiratory volume [FEV1], functional residual capacity [FRC]) before operation (T0) and 4 h (T4), 24 h (T24), 48 h (T48) after surgery. Anaesthesia technique was the same associating propofol-atracurium-fentanyl, 50% N2O/O2. Ventilation was adapted to maintain end-tidal carbon dioxide pressure up to 30-35 mmHg. Postoperative analgesic regimen consisted of paracetamol-ketoprofen. Mean length of surgery was 84 +/- 15 min; mean duration of anaesthesia was 110 +/- 24 min. An immediate and harmonious restrictive breathing pattern developed postoperatively. Postoperative FVC measured 65% (T4), 63% (T24), 72% (T48) of preoperative function (p < 0.025); postoperative FEV1 measured respectively 60, 66 and 75% of preoperative function (p > 0.001), without change in FEV1/CV and FRC; a significant hypoxia occurred (T0: 86 mmHg, T4: 80 mmHg, T24: 75 mmHg, T48: 81 mmHg [p < 0.05]). Laparoscopic cholecystectomy resulted in less postoperative respiratory dysfunction than conventional cholecystectomy, as previously reported; this restrictive pattern observed without changes in FRC was similar to that following lower abdominal surgery.
authors.affiliation: Département d'Anesthésie-Réanimation, Hôpital Nord, Saint-Priest-en-Jarez.
authors.forename: P
authors.initials: P
authors.lastname: Mahul
authors.forename: G
authors.initials: G
authors.lastname: Burgard
authors.forename: F
authors.initials: F
authors.lastname: Costes
authors.forename: B
authors.initials: B
authors.lastname: Guillot
authors.forename: N
authors.initials: N
authors.lastname: Massardier
authors.forename: Z
authors.initials: Z
authors.lastname: el Khouri
authors.forename: J
authors.initials: J
authors.lastname: Cuilleret
authors.forename: A
authors.initials: A
authors.lastname: Geyssant
authors.forename: C
authors.initials: C
authors.lastname: Auboyer
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000379:methods; D001784:Blood Gas Analysis; D002763:Cholecystectomy / Q000009:adverse effects; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012119:Respiration; D012129:Respiratory Function Tests
vernacular_title: Fonction respiratoire postopératoire et cholécystectomie par voie coelioscopique.