title: Resistance of Plasmodium falciparum to amodiaquine in Papua New Guinea.
abstract: The sensitivity of Plasmodium falciparum to amodiaquine was assessed in children in the Madang region of Papua New Guinea. Fifty-four tests in vivo were carried out and 19 (35%) of these showed resistance at the RII or RIII level. Twenty-two of the 43 isolates tested showed some degree of resistance to amodiaquine in vitro. A negative correlation between the age of the patient and apparent resistance of the parasite in vivo was observed. There was no correlation between resistance in vivo and in vitro.
authors.affiliation: Papua New Guinea Institute of Medical Research, Madang.
authors.forename: K R
authors.initials: KR
authors.lastname: Trenholme
authors.forename: D E
authors.initials: DE
authors.lastname: Kum
authors.forename: A K
authors.initials: AK
authors.lastname: Raiko
authors.forename: N
authors.initials: N
authors.lastname: Gibson
authors.forename: A
authors.initials: A
authors.lastname: Narara
authors.forename: M P
authors.initials: MP
authors.lastname: Alpers
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000655:Amodiaquine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000655:Amodiaquine