Ampicillin concentrations in radicular cysts following a single oral administration of bacampicillin.
1. Ampicillin concentrations in cyst wall (wall) and cyst fluid (fluid) of radicular cyst and serum following a single oral administration of bacampicillin (equivalent to 500 mg of ampicillin) were measured by a paper disk method. 2. The mean peak concentrations of ampicillin in wall, fluid, and serum occurred at identical times, 1.5 hr, and were 2.39 micrograms/g, 0.77, and 10.24 micrograms/ml, respectively. 3. Mean ampicillin concentration ratios of wall/serum, fluid/serum, and fluid/wall at the peak time were 0.23, 0.07, and 0.40, respectively. 4. Mean ampicillin concentrations in wall and fluid at the peak time exceeded MIC (minimum inhibitory concentration) for 90% (0.5 microgram/ml) for clinically isolated strains of alpha-hemolytic Streptococci.
Akimoto
Y
Y
Department of Oral Surgery 2, Nihon University School of Dentistry, Matsudo, Chiba, Japan.
Mochizuki
Y
Y
Uda
A
A
Shibutani
J
J
Nishimura
H
H
Komiya
M
M
Kaneko
K
K
Fujii
A
A
Yamamoto
H
H
D000284:Administration, Oral; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011842:Radicular Cyst / Q000378:metabolism*; D013297:Streptococcus pyogenes / Q000187:drug effects
D000667:Ampicillin; C011674:bacampicillin