title: Cerebrovascular and metabolic uncoupling in the caudate-putamen following unilateral lesion of the mesencephalic dopaminergic neurons in the rat.
abstract: Changes in local cerebral blood flow (lCBF) and local cerebral glucose utilization (lCGU) were assessed in dopaminergic primary target areas in the rat 6 weeks after unilateral lesion of dopaminergic neurons within the substantia nigra pars compacta (SNc) and adjacent ventrotegmental area (VTA) using 6-hydroxydopamine (6-OHDA). lCBF and lCGU were determined using the autoradiographic [14C]iodoantipyrine and [14C]2-deoxyglucose method. Dopaminergic deafferentation provoked a marked unilateral lCBF decrease in the dorso-lateral portion of the rostral caudate-putamen. The decrease in lCBF was not associated with significant changes in glucose metabolism. Thus, lesions of dopaminergic afferents to the caudate-putamen appear to provoke a sustained decrease in basal blood flow with unchanged local metabolic activity.
authors.affiliation: Laboratoire de Recherches Cérébrovasculaires (CNRS UA 641), Faculté de Médecine, Université Paris VII, France.
authors.forename: S
authors.initials: S
authors.lastname: Mraovitch
authors.forename: Y
authors.initials: Y
authors.lastname: Calando
authors.forename: B
authors.initials: B
authors.lastname: Onteniente
authors.forename: M
authors.initials: M
authors.lastname: Peschanski
authors.forename: J
authors.initials: J
authors.lastname: Seylaz
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D016923:Cell Death; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose / Q000378:metabolism; D004298:Dopamine / Q000032:analysis*; D004734:Energy Metabolism; D005260:Female; D008636:Mesencephalon / Q000098:blood supply / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D016627:Oxidopamine / Q000633:toxicity; D011699:Putamen / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016627:Oxidopamine; D003847:Deoxyglucose; D004298:Dopamine