[Early effects of neutron-gamma or gamma irradiation on the group toxicity induced by (+) amphetamine in mice].
To better understand the mechanism of action of gamma and neutron radiation on the dopaminergic system, the influence of the two irradiation modalities on the group toxicity of (+) amphetamine was studied in mice. Neutron-gamma irradiation (3.6-4.95 Gy) leads to an early toxicity reduction, while gamma-exposure (7-12 Gy) induces an increase in toxicity. This suggests that these two types of radiation induce different early effects on central dopaminergic system. Possible mechanisms are discussed.
Martin
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C
Unités de Radioprotection et de Biomathématiques et Informatique, Centre de Recherches du Service de Santé des Armées, Grenoble, France.
Janodet
D
D
Job
A
A
Eschenbrenner
M
M
Fatôme
M
M
D000206:Actuarial Analysis; D000661:Amphetamine / Q000528:radiation effects / Q000633:toxicity*; D000818:Animals; D004298:Dopamine / Q000502:physiology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D051379:Mice; D009502:Neutrons
D000661:Amphetamine; D004298:Dopamine
Effets précoces de l'irradiation neutron-gamma ou gamma sur la toxicité de groupe induite par la (+) amphétamine chez la souris.