A ureteral small cell carcinoma mixed with malignant mesodermal and ectodermal elements: a clinicopathological, morphological and immunohistochemical study.
A 60-year-old male with a small cell carcinoma of the right lower ureter is presented. The tumor mainly comprised a small cell carcinoma but also included a full variety of histological types such as transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, leiomyosarcoma and chondrosarcoma. Immunohistochemical staining was positive for neuron specific enolase and cluster 1 small cell lung cancer antigen/N-CAM in the small cell carcinoma and S-100 in the chondrosarcoma component. The patient underwent a right nephroureterectomy, and received prophylactic radiation of the pelvic and para-aortic lymph node regions and cisplatin and etoposide combination chemotherapy. Eight months after the chemotherapy, a transitional cell carcinoma was found in the bladder neck, and a cystectomy with urethrectomy performed. To our knowledge, this is the second report of a small cell carcinoma originating from the ureter.
Tsutsumi
M
M
Urology Division, National Cancer Center Hospital, Tokyo.
Kamiya
M
M
Sakamoto
M
M
Tobisu
K
K
Kakizoe
T
T
D015415:Biomarkers / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002296:Carcinosarcoma / Q000737:chemistry / Q000473:pathology*; D004475:Ectoderm; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008648:Mesoderm; D008875:Middle Aged; D014516:Ureteral Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
D015415:Biomarkers