title: Diabetic ketoacidosis in a hospital based population in Pakistan.
abstract: Sixty-two consecutive episodes of diabetic ketoacidosis (DKA) were studied at Aga Khan University Hospital, Karachi. Forty-four (71%) were type I and 18 (29%) type II diabetics. Mean age was 28.1 years and mean duration of diabetes 4.1 years. Infections were the most common precipitating factor accounting for 28 episodes (45.2%). Twenty-two patients (35.5%) had hyperosmolality (serum osmolality > 320 mosmol/L). Mean serum Na+ was 131.7 mmol/L and K+ 4.6 mmol/L. Twenty-three (37.1%) were hyperkalemic at presentation with seven patients (11.3%) being comatosed and 35 (56.5%) alert. Mean random blood glucose (RBG) was 624 mg/dl, mean pN 7.09, osmolality 316 mosmol/L and the neurological status correlated statistically significantly with mean RBG, pH and osmolality. A leukemoid response was seen in 83.9% episodes. Mortality rate was 8.0% in patients with DKA managed in this hospital.
authors.affiliation: Department of Medicine, Aga Khan University Hospital, Karachi.
authors.forename: J
authors.initials: J
authors.lastname: Akhter
authors.forename: A
authors.initials: A
authors.lastname: Jabbar
authors.forename: N
authors.initials: N
authors.lastname: Islam
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D016883:Diabetic Ketoacidosis / Q000209:etiology / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D012189:Retrospective Studies