Convulsions induced by methyl beta-carboline-3-carboxylate in mice: effects of preceding saline injections.
The convulsant effects of a high (5 mg/kg intraperitoneally, i.p.) dose of benzodiazepine (BZD) receptor ligand methyl beta-carboline-3-carboxylate (beta-CCM), whether or not preceded by administration of two lower doses of beta-CCM (0.5 and 1 mg/kg i.p.) or of saline were studied in nine inbred mouse strains. In five of the strains (A/J, BALB/cBy, C3H/HeJ, CBA/H, and DBA/2J), neither saline nor preceding injections of beta-CCM had any effect on subsequent reactivity to the subsequent convulsant dose. In the other 4 strains, such injections induced either tolerance (CPB-K, NZB), or sensitization (C57BL/6J, XLII), whatever the compound subsequently administered (beta-CCM or saline). In these strains, the data rule out any tolerance or sensitization effect due to beta-CCM, but suggest that such effects could be due to injection itself.
Martin
B
B
Génétique, Neurogénétique et Comportement, URA CNRS 1294, Paris, France.
Venault
P
P
Chapouthier
G
G
D000818:Animals; D002243:Carbolines / Q000008:administration & dosage / Q000494:pharmacology; D003292:Convulsants / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D007274:Injections, Intraperitoneal; D007696:Kindling, Neurologic / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*; D012965:Sodium Chloride / Q000494:pharmacology; D013045:Species Specificity
D002243:Carbolines; D003292:Convulsants; D011963:Receptors, GABA-A; D012965:Sodium Chloride; C036150:beta-carboline-3-carboxylic acid methyl ester