Cutaneous and ocular changes associated with the use of chlorpromazine.
A 57-year-old schizoaffective disorder patient was placed on chlorpromazine because of its sedative properties and low profile for extrapyramidal side effects. After two years of treatment, the patient developed photosensitivity and blue-gray pigmentation of the skin of the face, neck and dorsum of hands. Significant pigment deposits were also observed in eye lens and cornea. An oval translucent lesion lateral to the left angle of the mouth was removed and the biopsy showed a basal cell carcinoma. The cutaneous and eye pigmentation were only partially reversible after the discontinuation of chlorpromazine. There has been no recurrence of basal cell carcinoma.
Wolf
M E
ME
Department of Psychiatry, VA Medical Center, North Chicago, IL.
Richer
S
S
Berk
M A
MA
Mosnaim
A D
AD
D002280:Basal Cell Carcinoma / Q000139:chemically induced / Q000473:pathology; D002746:Chlorpromazine / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology*; D005128:Eye Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000473:pathology; D011618:Psychotic Disorders / Q000188:drug therapy
D002746:Chlorpromazine