title: Liposome-encapsulated gentamicin treatment of Mycobacterium avium-Mycobacterium intracellulare complex bacteremia in AIDS patients.
abstract: TLC G-65, a liposome-encapsulated gentamicin, was given intravenously twice weekly for 4 weeks to AIDS patients with Mycobacterium avium-M. intracellulare complex (MAC) bacteremia at 1.7 mg of gentamicin per kg of body weight per infusion (4 patients), 3.4 mg/kg (10 patients), and 5.1 mg/kg (7 patients). MAC colony counts in blood fell by 75% or more in all three groups (P < 0.005). Drug resistance did not emerge during the study period. Transient renal insufficiency developed in one patient; no other adverse effects were detected. Liposome-encapsulated gentamicin is a potential therapy for MAC infections in AIDS patients.
authors.affiliation: Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103.
authors.forename: S D
authors.initials: SD
authors.lastname: Nightingale
authors.forename: S L
authors.initials: SL
authors.lastname: Saletan
authors.forename: C E
authors.initials: CE
authors.lastname: Swenson
authors.forename: A J
authors.initials: AJ
authors.lastname: Lawrence
authors.forename: D A
authors.initials: DA
authors.lastname: Watson
authors.forename: F G
authors.initials: FG
authors.lastname: Pilkiewicz
authors.forename: E G
authors.initials: EG
authors.lastname: Silverman
authors.forename: S X
authors.initials: SX
authors.lastname: Cal
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial; D004337:Drug Carriers; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008081:Liposomes; D008297:Male; D015269:Mycobacterium avium Complex / Q000187:drug effects / Q000254:growth & development; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D004337:Drug Carriers; D005839:Gentamicins; D008081:Liposomes