title: [Non-Hodgkin's T cell lymphoma associated with marked eosinophilia].
abstract: A case of non-Hodgkin's T cell lymphoma (diffuse lymphoma, large cell type) associated with marked eosinophilia and pleurisy in a 57-year-old male is reported. The leukocyte count was 12.5 x 10(3)/microliters and eosinophil count was 53% and the absolute count of 6.6 x 10(3)/microliters. The patient's serum and pleural effusion fluid, containing abundant lymphoma cells, showed eosinophil colony stimulating factor (Eo-CSF) activity. Conditioned medium (CM) prepared from patient's T cells (T-CM) produced Eo-CSF and this was enhanced by interleukin-2 (IL-2) stimulation. We demonstrated that the patient's serum contained a significant amount of interleukin-5 (IL-5) and the patient's T-CM, particularly after IL-2 stimulation contained a significant amount of granulocyte-macrophage colony-stimulating factor (GM-CSF). These findings suggest that Eo-CSF produced by neoplastic T cells or normal T cells activated by tumor antigen stimulated the production of eosinophils in this patient and that both IL-5 and GM-CSF might play a role in Eo-CSF activity.
authors.affiliation: Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital.
authors.forename: J
authors.initials: J
authors.lastname: Tomiyama
authors.forename: H
authors.initials: H
authors.lastname: Kudoh
authors.forename: F
authors.initials: F
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Adachi
authors.forename: H
authors.initials: H
authors.lastname: Enokihara
mesh_terms: D004802:Eosinophilia / Q000150:complications / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006801:Humans; D015848:Interleukin-5 / Q000502:physiology; D016399:Lymphoma, T-Cell / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010998:Pleurisy / Q000150:complications / Q000276:immunology*
chemical_list: D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor