Cytokines and peripheral tolerance to alloantigen.
The induction of peripheral tolerance to alloantigen is accompanied in many cases by a decrease in the production of cytokines such as IL-2 and IFN gamma, yet a sustained production of cytokines such as IL-10 and IL-4. Whether or not this altered pattern of cytokine production in tolerant animals is causally related to the induction and/or maintenance of the tolerant state has yet to be fully determined, although experiments blocking selectively the action of IL-2 with CD25 antibodies suggest that manipulation of cytokine production may at least be a route to tolerance. Alternative methods for directly influencing the cytokine balance are sought and recent experiments on the CD28/CTLA-4-B7 interaction suggest a possible approach.
Dallman
M J
MJ
University of Oxford, Nuffield Department of Surgery, John Radcliffe Hospital, Headington, England.
Wood
K J
KJ
Hamano
K
K
Bushell
A R
AR
Morris
P J
PJ
Wood
M J
MJ
Charlton
H M
HM
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007519:Isoantigens / Q000276:immunology*; D014181:Transplantation Immunology
D016207:Cytokines; D007519:Isoantigens