Demineralized bone matrix. Enhancement of spinal fusion.
A study was conducted to determine the ability of demineralized bone matrix gel to act as an osteoconductive/osteoinductive material to enhance canine spinal fusion. Seven dogs underwent posterior spinal fusion. Four-level fusions were performed with one of four procedures at each level: decortication alone, with gel added, with autograft, or with both gel and autograft. Dogs were killed at 6 weeks and early histologic response was studied. At untreated control sites, little bone formation was evident. Gel-filled sites showed abundant osteoid, with 60% of demineralized particles fused to or surrounded by new bone. Sites filled with autograft had more new bone, but there was more osteoid at gel-treated sites. Autograft augmented with gel showed the most vigorous response, with extensive bridging between demineralized particles, host bone, autograft, and new bone. Significantly less autograft was needed to induce a similar amount of new bone formation when gel was added. Use of the gel as an autograft extender may improve the chance for successful spinal fusion.
Frenkel
S R
SR
Hospital for Joint Diseases Orthopaedic Institute, New York, New York.
Moskovich
R
R
Spivak
J
J
Zhang
Z H
ZH
Prewett
A B
AB
D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D001862:Bone Resorption; D016025:Bone Transplantation; D002113:Calcification, Physiologic; D004285:Dogs; D005782:Gels; D008297:Male; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D011184:Postoperative Period; D011859:Radiography; D013123:Spinal Fusion / Q000379:methods*; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology; D014182:Transplantation, Autologous
D005782:Gels