The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis.
Feeding of fluorinated benzoic acids to fermentations of a Phoma sp. resulted in the biosynthesis of a series of novel fluorinated squalestatins. The feeding studies, isolation, structural elucidation and biological activities of these compounds are reported.
Cannell
R J
RJ
Department of Natural Products Discovery, Research Limited, Middlesex, U.K.
Dawson
M J
MJ
Hale
R S
RS
Hall
R M
RM
Noble
D
D
Lynn
S
S
Taylor
N L
NL
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D002176:Candida albicans / Q000201:enzymology; D002851:Chromatography, High Pressure Liquid; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D005285:Fermentation; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism*; D015394:Molecular Structure; D051381:Rats; D014233:Tricarboxylic Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
D001643:Bridged Bicyclo Compounds; D014233:Tricarboxylic Acids; D013186:Farnesyl-Diphosphate Farnesyltransferase