Influence of Abana on experimental atherogenesis in hypercholesterolemic rabbits.
An experimental, placebo-controlled study with rabbits was conducted to determine the role of Abana, an Ayurvedic preparation, on atherosclerosis. The results showed that Abana arrested the rise in TC, LDLc and VLDLc when administered along with an atherogenic diet for 60 days. In another phase of the study, when Abana was given from days 60-120 to rabbits who were made hyperlipidemic by feeding them an atherogenic diet for 60 days, Abana brought the TC, LDLc and VLDLc levels back to normal. On the other hand, the levels of the cardioprotective HDLc were elevated by Abana administration in both phases of the study. Histological pictures showed pronounced reduction in the atherosclerotic involvement of the coronary artery following treatment with Abana. The architecture of the coronary artery returned almost to normal. These findings substantiate the possible role of Abana in the reduction, prevention and reversal of atherosclerosis.
Tiwari
A K
AK
Centre for Experimental Medicine and Surgery, Banaras Hindu University, Varanasi, India.
Gode
J D
JD
Dubey
G P
GP
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003324:Coronary Artery Disease / Q000473:pathology / Q000517:prevention & control; D003331:Coronary Vessels / Q000473:pathology; D004036:Diet, Atherogenic; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications*; D008297:Male; D008903:Minerals / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008903:Minerals; D010936:Plant Extracts; D014280:Triglycerides; C064613:abana