title: Glioblastoma multiforme of donor origin after renal transplantation: report of a case.
abstract: A case of transmission of a glioblastoma multiforme from the donor to a kidney transplant recipient in the absence of previous ventriculosystemic shunt is described. The recipient was a 48-year-old woman who developed a fever with no other associated symptoms 17 months posttransplant. Physical examination revealed a large nonpulsatile mass on the upper graft pole. Histopathologic examination showed a highly cellular neoplasm with fusiform and globoid cells, a high grade of nuclear pleomorphism and mitosis, necrosis with pseudopalisading, and vascular proliferation. Immunohistochemistry of the cells showed them to contain glial fibrillary acidic and S-100 proteins, consistent with a glioblastoma multiforme. We conclude that the risk of tumor transmission from donors with primary central nervous system tumors to kidney transplant recipients, is real and should be considered when evaluating a graft mass in such patients.
authors.affiliation: Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Faculty of Medicine, University of Cantabria, Santander, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Val-Bernal
authors.forename: J C
authors.initials: JC
authors.lastname: Ruiz
authors.forename: J G
authors.initials: JG
authors.lastname: Cotorruelo
authors.forename: M
authors.initials: M
authors.lastname: Arias
mesh_terms: D000328:Adult; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005909:Glioblastoma / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D014019:Tissue Donors
chemical_list: D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins