Chromosomal translocation t(13;16) in a patient with idiopathic hypogonadotropic hypogonadism.
A patient with idiopathic hypogonadotropic hypogonadism (IHH) had an apparently balanced reciprocal translocation involving chromosomes 13 and 16 [t(13;16)(q14.11;q24)]. The patient's father has the same chromosomal translocation with no apparent physical abnormalities. The role of the chromosomal translocation in this patient is discussed.
Kikuchi
I
I
Department of Internal Medicine, Miyazaki Prefectural Hospital, Japan.
Nagamine
M
M
Ueda
A
A
Mihara
K
K
Seita
M
M
Minoda
M
M
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13 / Q000648:ultrastructure*; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D004542:Ejaculation; D007172:Erectile Dysfunction / Q000235:genetics*; D005640:Follicle Stimulating Hormone / Q000172:deficiency; D007987:Gonadotropin-Releasing Hormone / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000235:genetics*; D017436:Kallmann Syndrome / Q000235:genetics; D007986:Luteinizing Hormone / Q000172:deficiency; D008297:Male; D010375:Pedigree; D010906:Pituitary Hormone-Releasing Hormones; D013739:Testosterone / Q000172:deficiency; D014178:Translocation, Genetic
D010906:Pituitary Hormone-Releasing Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone