title: Anorectal stenosis in patients with prolonged use of suppositories containing paracetamol and acetylsalicylic acid.
abstract: We report five cases in which anorectal stenosis was associated with chronic administration of suppositories containing paracetamol and acetylsalicylic acid. All patients were females taking suppositories for chronic migraine. Patients experienced anal pain, tenesmus, fecal incontinence, and, in two cases, intestinal obstruction. Lesions were characterized by a severe circular narrowing of the distal rectum with superficial ulcerations. Radiographs demonstrated the presence of sinus-tract-like formations in the diseased segment and thickening of the rectal wall. Histologic examination showed signs of chronic inflammation with deep ulcerations associated with obliteration of the lamina propria by a fibromuscular proliferation, as was described in the solitary ulcer syndrome of the rectum. Rectal administration of suppositories was discontinued in all the patients. Two patients were improved by anorectal dilatation, but the remaining three required a left proctocolectomy with subsequent coloanal anastomosis. The use of such suppositories must be restricted.
authors.affiliation: Medico-surgical Department of Gastroenterology, Hôpital Erasme, Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Van Gossum
authors.forename: M
authors.initials: M
authors.lastname: Zalcman
authors.forename: M
authors.initials: M
authors.lastname: Adler
authors.forename: M O
authors.initials: MO
authors.lastname: Peny
authors.forename: J J
authors.initials: JJ
authors.lastname: Houben
authors.forename: M
authors.initials: M
authors.lastname: Cremer
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000285:Administration, Rectal; D000328:Adult; D001004:Anus Diseases / Q000139:chemically induced* / Q000175:diagnosis; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000175:diagnosis; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy; D012002:Rectal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D013488:Suppositories; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D013488:Suppositories; D000082:Acetaminophen; D001241:Aspirin