title: MHC haplotype influences primary Giardia muris infections in H-2 congenic strains of mice.
abstract: The course of primary Giarda muris infections was studied in H-2 congenic strains of mice on the BALB and C57BL/10 (B10) genetic backgrounds. Infection was curtailed more rapidly in B10 strains, compared with BALB strains, and unaffected by H-2 haplotype. On the other hand the duration of infection in BALB strains did vary with H-2 haplotype with BALB/B(H-2b) mice taking significantly longer to clear infection than BALB/c(H-2d) and BALB/K(H-2k) mice. These experiments demonstrate that both MHC and non-MHC genes influence the outcome of primary G.muris infections.
authors.affiliation: Department of Life Science, University of Nottingham, UK.
authors.forename: P
authors.initials: P
authors.lastname: Venkatesan
authors.forename: R G
authors.initials: RG
authors.lastname: Finch
authors.forename: D
authors.initials: D
authors.lastname: Wakelin
mesh_terms: D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D005873:Giardiasis / Q000276:immunology*; D006183:H-2 Antigens / Q000276:immunology*; D006239:Haplotypes / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
chemical_list: D006183:H-2 Antigens