Opsonization of Anaplasma marginale mediated by bovine antibody against surface protein MSP-1.
Antibody from cattle immunized with purified major surface protein-1 (MSP-1) was demonstrated to significantly enhance phagocytosis of Florida strain Anaplasma marginale by bovine macrophages in vitro. Serum immunoglobulin from individual MSP-1 immunized, protected cattle varied in ability to promote phagocytosis, however all sera were significantly opsonic as compared with sera from sham immunized control cattle.
Cantor
G H
GH
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 991674-7040.
Pontzer
C H
CH
Palmer
G H
GH
D000709:Anaplasma / Q000276:immunology*; D000712:Anaplasmosis / Q000276:immunology; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D002417:Cattle; D002478:Cells, Cultured; D008264:Macrophages / Q000276:immunology; D020066:Merozoite Surface Protein 1; D009895:Opsonin Proteins / Q000276:immunology*; D010587:Phagocytosis; D011498:Protein Precursors / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*
D000907:Antibodies, Bacterial; D000954:Antigens, Surface; D020066:Merozoite Surface Protein 1; D009895:Opsonin Proteins; D011498:Protein Precursors; D015800:Protozoan Proteins