title: Effect of prednisone on renal function in man.
abstract: To clarify the rise in plasma creatinine concentration previously observed during prednisone treatment, we studied changes in renal function in Graves' ophthalmopathy patients before and after 2 weeks of either prednisone 60 mg/day or retrobulbar radiotherapy (controls). Compared to retrobulbar radiotherapy, prednisone treatment was associated with an increase in: (a) plasma creatinine concentration (from 68 +/- 4 to 76 +/- 4 mumol/l), (b) glomerular filtration rate (GFR, from 93 +/- 4 to 102 +/- 5 ml/min/1.73 m2), and (c) urinary creatinine excretion rate (from 510 +/- 40 to 570 +/- 40 mumol/h). We conclude that GFR rises during 2 weeks of high-dose prednisone administration, a rise that is not reflected by a decrease in plasma creatine concentration. On the contrary, both plasma creatinine concentration and urinary creatinine excretion increase, probably as a result of the catabolic effect of prednisone. As established by the present study, prednisone 60 mg/day is associated with protein wasting, also after 14 days of treatment.
authors.affiliation: Department of Nephrology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: van Acker
authors.forename: M F
authors.initials: MF
authors.lastname: Prummel
authors.forename: J A
authors.initials: JA
authors.lastname: Weber
authors.forename: W M
authors.initials: WM
authors.lastname: Wiersinga
authors.forename: L
authors.initials: L
authors.lastname: Arisz
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000503:physiopathology / Q000532:radiotherapy; D006801:Humans; D007444:Inulin / Q000097:blood / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects
chemical_list: D007444:Inulin; D003404:Creatinine; D011241:Prednisone