title: Ultrastructural changes in rat mammotropes following incubation with dopamine.
abstract: Cultured mammotropes incubated with dopamine for one hour exhibited changes in ultrastructure indicative of actively depressed biosynthetic and secretory activity. Peripheral relocation of rough endoplasmic reticulum appeared to create a barrier to secretory granule release by exocytosis. A decrease in the numbers of secretory granules indicated a decrease in prolactin production and enhanced lysosomal activity.
authors.affiliation: Department of Anatomy, Queen's University, Kingston, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Joneja
authors.forename: C W
authors.initials: CW
authors.lastname: Reifel
authors.forename: M L
authors.initials: ML
authors.lastname: Murphy
authors.forename: S H
authors.initials: SH
authors.lastname: Shin
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D004298:Dopamine / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000648:ultrastructure*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011388:Prolactin; D004298:Dopamine