Microiontophoresis of baclofen on membrane potential and input resistance in bulbar respiratory neurons in the cat.
Iontophoresis of baclofen produced hyperpolarization and a decrease in input resistance in 32 neurons and no effect in 24 neurons of the ventral respiratory group in cats. Iontophoresed phaclofen antagonized the effect of baclofen, but had negligible effects on periodic fluctuations in membrane potential and spike activity in these neurons. The hyperpolarizing effect of baclofen persisted after iontophoresis of tetrodotoxin, suggesting that baclofen acted directly at the postsynaptic gamma-aminobutyric acid (GABA)B receptors.
Haji
A
A
Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Takeda
R
R
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002415:Cats; D007478:Iontophoresis; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D012137:Respiratory System / Q000294:innervation*; D013779:Tetrodotoxin / Q000494:pharmacology
C052329:phaclofen; D013779:Tetrodotoxin; D001418:Baclofen