[Influence of ethanol and ethanol-induced lipid peroxidation on the steroidogenic activity of testicles].
Chronic alcohol intoxication results in the diminished testosterone level and activation of lipid peroxidation in rat testes. A significant decrease in 3 beta-hydroxysteroid-hydrogenase and 17-dehydrogenase activity has been observed in microsomes. Analogous shifts have been evoked in vitro by the induction of lipid peroxidation in microsomes. That permitted one to suppose that alcohol-induced alterations in tests are partially mediated by induction of lipid peroxidation.
Kashko
M F
MF
Khokha
A M
AM
Antsulevich
S N
SN
Doroshkevich
N A
NA
Voronov
P P
PP
D000437:Alcoholism / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D013256:Steroids / Q000096:biosynthesis*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
D013256:Steroids; D000431:Ethanol
Vliianie étanola i indutsiruemogo im perekisnogo okisleniia lipidov na steroidogennuiu aktivnost' semennikov.