title: Preservation of cranial nerve function after radiosurgery for nonacoustic schwannomas.
abstract: Microsurgical resection is the primary management approach for patients with intracranial schwannomas. Recent studies have demonstrated that stereotactic radiosurgery is an effective therapeutic modality for patients with acoustic schwannomas. To define the role of radiosurgery in the management of patients with nonacoustic schwannomas, we reviewed the results of gamma unit stereotactic radiosurgery in six patients with trigeminal and five patients with jugular foramen region schwannomas. No patient with a trigeminal schwannoma demonstrated tumor growth during a mean follow-up of 21 months (range, 7-35 mo), whereas one patient with a jugular foramen region schwannoma had an increase in tumor size 7 months after radiosurgery. No new cranial nerve or brain stem deficits were noted in either patient group after radiosurgery. In this early experience, radiosurgery proved an effective primary or adjuvant technique for selected patients with schwannomas of the trigeminal, glossopharyngeal, or vagus nerves. Using our described method, the safety of radiosurgery was demonstrated on the brain stem, regional cranial nerves, and especially those cranial nerves intimately associated with the tumor.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: B E
authors.initials: BE
authors.lastname: Pollock
authors.forename: D
authors.initials: D
authors.lastname: Kondziolka
authors.forename: J C
authors.initials: JC
authors.lastname: Flickinger
authors.forename: A
authors.initials: A
authors.lastname: Maitz
authors.forename: L D
authors.initials: LD
authors.lastname: Lunsford
mesh_terms: D003390:Cranial Nerve Neoplasms / Q000175:diagnosis / Q000601:surgery*; D005500:Follow-Up Studies; D005930:Glossopharyngeal Nerve / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007601:Jugular Veins / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009442:Neurilemmoma / Q000175:diagnosis / Q000601:surgery*; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000209:etiology; D016634:Radiosurgery; D014057:Tomography, X-Ray Computed; D014276:Trigeminal Nerve / Q000473:pathology / Q000601:surgery*; D014630:Vagus Nerve / Q000473:pathology / Q000601:surgery*