title: Equilibrium and kinetic studies of the interaction of the benzimidazole dye Hoechst 8208 with nucleic acids.
abstract: The interaction of the benzimidazole dye Hoechst 8208 (H8208) with nucleic acids has been studied by temperature-jump relaxation method. The dependence of relaxation times on the nucleic acid concentration indicates that H8208 binds to RNA by a single biomolecular reaction and to DNA by a bimolecular reaction, followed by a slow isomerization.
authors.affiliation: Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry*; D002417:Cattle; D004396:Coloring Agents / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry; D007700:Kinetics; D009696:Nucleic Acids / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D001562:Benzimidazoles; D004396:Coloring Agents; D007364:Intercalating Agents; D009696:Nucleic Acids; C023989:H8208