title: [Lipid adjustment of alpha-tocopherol concentrations in plasma].
abstract: Measurement of alpha-tocopherol concentrations circulating either in plasma or serum is the most common method of measuring the vitamin E status in men. The analytical determination with a suitable HPLC method produces precise and reliable results. The interpretation of the measured alpha-tocopherol values is complicated by the strong positive correlation with different blood lipids. A considerable misinterpretation of the data will occur if these confounding factors are not taken into account by a suitable adjustment. Different methods have been described in the literature which tried to control the confounding effect of blood lipids. These methods were not completely satisfying. Therefore, a mathematical regression model, based on residuals, is introduced and applied to the data of the VERA-study (Verbundstudie Ernährungserhebung und Risikofaktoren Analytik) and the consequences of the lipid-adjustment of the tocopherol values are studied in further statistical procedures. Thereafter, lipid-adjusted tocopherol concentrations can be subjected to more extensive statistical evaluations without the requirement of special stratification.
authors.affiliation: Institut für Ernährungswissenschaft, Justus-Liebig-Universität, Giessen.
authors.forename: H
authors.initials: H
authors.lastname: Heseker
authors.forename: M
authors.initials: M
authors.lastname: Kohlmeier
authors.forename: R
authors.initials: R
authors.lastname: Schneider
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012727:Sex Characteristics; D014810:Vitamin E / Q000097:blood*
chemical_list: D008055:Lipids; D014810:Vitamin E
vernacular_title: Lipid-Adjustierung von alpha-Tocopherolkonzentrationen im Plasma.