[Effects of obstructive jaundice on immunocompetence in jaundiced patients].
Using CD series monoclonal antibody indirect immune fluorescent assay and LDH enzyme-release assay, we investigated lymphocyte subsets and natural killer cells (NKC) activity in the peripheral blood of 30 patients with obstructive jaundice. The results showed that the percentage of CD3+, CD4+, B cells and that of CD8+ was high. The ratio of CD4/CD8 was low at the first 10 days of jaundice when the serum bilirubin level was less than 171 mumol/L. Our studies suggested that obstructive jaundice might cause depression and impairment of host cellular and humoral immunity. Further studies showed that impaired immune function of jaundiced patients returned to normal 30 days after the disappearance of the jaundice by external or internal biliary drainage. Immune function recovered 30 days after relief of biliary obstruction and external or internal biliary drainage. External or internal biliary drainage was useful in improving host immunity.
Wang
Q H
QH
Ruijin Hospital, Shanghai Second Medical University.
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D002779:Cholestasis / Q000276:immunology* / Q000601:surgery; D004322:Drainage / Q000379:methods; D005260:Female; D006801:Humans; D007121:Immunocompetence; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*