[Recurrent nodular panniculitis in alpha 1-antitrypsin deficiency. Successful dapsone therapy].
We present a 59-year-old woman with chronically relapsing and necrotizing nodular panniculitis and associated alpha 1-antitrypsin deficiency. All cutaneous symptoms cleared for the first time in 10 years once she started treatment with dapsone. Chronic panniculitis should lead the clinician to determine plasma alpha 1-antitrypsin levels in more cases.
Schadendorf
D
D
Universitätsklinik Rudolf Virchow, Abteilung für Dermatologie, Berlin.
Haas
N
N
Nürnberger
F
F
Czarnetzki
B M
BM
D003176:Complement C3 / Q000032:analysis; D003622:Dapsone / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged; D010201:Panniculitis, Nodular Nonsuppurative / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence; D012867:Skin / Q000473:pathology; D019896:alpha 1-Antitrypsin Deficiency
D003176:Complement C3; D007075:Immunoglobulin M; D003622:Dapsone
Rezidivierende noduläre Pannikulitis bei alpha 1-Antitrypsinmangel. Erfolgreiche Dapson-Therapie.