[Hypothalamic syndromes. Review of clinical and endocrinal semiology].
A case of hypothalamic dysfunction in a girl with a twelve-year follow-up is reported. Onset occurred at the age of three with severe obesity, hypothermia, hypersomnia, and lethargy. Somatotropic, gonadotropic, and thyrotropic hormones were low, whereas prolactin was increased. Imaging techniques failed to disclose any lesion of the hypothalamus or pituitary. Clomipramine improved the vegetative disorders. The literature on clinical and hormonal disorders of hypothalamic dysfunction is reviewed.
Joseph
M G
MG
Service de Pédiatrie B, Centre Robert Debré, CHU, Angers.
Jouanny
A C
AC
Chomienne
F
F
Champion
G
G
Giniès
J L
JL
Limal
J M
JM
D002675:Child, Preschool; D002997:Clomipramine / Q000627:therapeutic use; D006970:Disorders of Excessive Somnolence / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006062:Gonadotropins / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007027:Hypothalamic Diseases / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D007035:Hypothermia / Q000209:etiology*; D009765:Obesity / Q000209:etiology*; D011388:Prolactin / Q000097:blood; D012894:Sleep Stages / Q000502:physiology*; D013577:Syndrome; D013972:Thyrotropin / Q000097:blood
D006062:Gonadotropins; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D002997:Clomipramine
Syndromes hypothalamiques. Revue de la sémiologie clinique et endocrinienne.