Localization of the Na+/glucose cotransporter gene SGLT2 to human chromosome 16 close to the centromere.
The chromosomal location of the gene SGLT2, which is presumed to encode a low-affinity Na+/glucose cotransporter, has been determined using a panel of rodent-human somatic cell hybrids. Southern blot analysis of genomic DNA from 16 different hybrids shows that SGLT2 is located on chromosome 16. Analysis of three additional hybrids that selectively retain all or part of human chromosome 16 demonstrates that SGLT2 is located close to the centromere in band p11.2 of the chromosome.
Wells
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RG
Renal Division, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Mohandas
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TK
Hediger
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MA
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D006224:Cricetinae; D018076:DNA, Complementary; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009004:Monosaccharide Transport Proteins / Q000235:genetics*
D018076:DNA, Complementary; D009004:Monosaccharide Transport Proteins