title: Virulence of two Streptococcus pyogenes strains (types M1 and M3) associated with toxic-shock-like syndrome depends on an intact mry-like gene.
abstract: The major virulence factor of Streptococcus pyogenes, the M protein, is positively regulated at the transcriptional level by mry in the M type 6 strain studied. We show here that in two S. pyogenes strains isolated from cases of toxic-shock-like syndrome, a type M1 strain and a type M3 strain, an mry-like gene is also required for resistance to phagocytosis.
authors.affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322.
authors.forename: J F
authors.initials: JF
authors.lastname: Perez-Casal
authors.forename: H F
authors.initials: HF
authors.lastname: Dillon
authors.forename: L K
authors.initials: LK
authors.lastname: Husmann
authors.forename: B
authors.initials: B
authors.lastname: Graham
authors.forename: J R
authors.initials: JR
authors.lastname: Scott
mesh_terms: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002352:Carrier Proteins; D005340:Fibrinogen / Q000378:metabolism; D005798:Genes, Bacterial; D006801:Humans; D016254:Mutagenesis, Insertional; D010587:Phagocytosis; D011485:Protein Binding; D012772:Shock, Septic / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein; D005340:Fibrinogen