[Effect of liposomes on tissue respiration in animals with acute hypoxic hypoxia].
Introduction of liposomas has been studied in experiments on Wistar rats for its effect on oxygen demand by tissues of the brain great hemispheres, lungs, liver and femoral muscle under acute hypoxic hypoxia due to inhalation by an animal of gas mixtures containing of 6.7-7.1% of O2. It is shown that after introduction of phospholipid liposomes as a lipin preparation against a background of acute and grave forms of hypoxic hypoxia the oxygen demand of tissues remains practically at the level of control values. This proves absence of the tissue oxygen debt that usually develops at hypoxic states. It is concluded that the organism tissues in the presence of liposomas do not practically suffer from the oxygen deficiency and introduction of lipin may be effective to prevent from development of the secondary tissue hypoxia.
Seredenko
M M
MM
Nazarenko
A I
AI
Kukoba
T V
TV
D000208:Acute Disease; D000818:Animals; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism*; D008081:Liposomes / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D010743:Phospholipids / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D008081:Liposomes; D010743:Phospholipids
Vplyv liposom na stan tkanynnoho dykhannia u tvaryn pry hostriĭ hipoksychniĭ hipoksiĭ.