title: New inhibitors of melanogenesis, OH-3984 K1 and K2. I. Taxonomy, fermentation, isolation and biological characteristics.
abstract: Melanogenesis inhibitors, OH-3984 K1 and K2 were isolated from fermentation broth of Streptomyces sp. OH-3984. OH-3984 K1 and K2 inhibited the melanogenesis of B16 melanoma cells at concentrations of 7.5 and 3.8 micrograms/ml, respectively, whereas inhibition of tyrosinase activity has not been observed. The microbial metabolites showed no antimicrobiological activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.
authors.affiliation: Kitasato Institute, Kitasato University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Komiyama
authors.forename: S
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Shinose
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Iwai
authors.forename: S
authors.initials: S
authors.lastname: Omura
authors.forename: G
authors.initials: G
authors.lastname: Imokawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D014442:Monophenol Monooxygenase / Q000378:metabolism; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; D008543:Melanins; C084381:OH 3984 K1; C084382:OH 3984 K2; D014442:Monophenol Monooxygenase