A new calcitonin-receptor-like sequence in rat pulmonary blood vessels.
1. Two rat clones have been isolated which are similar to known calcitonin-receptor sequences. One of these does not have the distribution expected of a calcitonin receptor. It is widely distributed, with extremely high levels of expression in the lung, where it is associated with the blood vessels. 2. This rat sequence may represent the receptor for calcitonin-gene-related peptide or islet amyloid polypeptide. Both have binding activity in the lung and are potent vasodilators. The gene represented by this sequence may therefore play an important role in the maintenance of vascular tone.
Njuki
F
F
Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Nicholl
C G
CG
Howard
A
A
Mak
J C
JC
Barnes
P J
PJ
Girgis
S I
SI
Legon
S
S
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D017403:In Situ Hybridization; D008168:Lung / Q000098:blood supply*; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015347:RNA Probes; D051381:Rats; D017208:Rats, Wistar; D018003:Receptors, Calcitonin / Q000737:chemistry*
D015347:RNA Probes; D018003:Receptors, Calcitonin