title: Podoconiosis in the Ethiopian Rift Valley. Role of beryllium and zirconium.
abstract: A geogenic origin has been proposed in the aetiology of non-filarial elephantiasis of the feet and legs, recently renamed podoconiosis. Soil collected in an area of the Ethiopian Rift Valley, the borough of Ocholo, known for its high prevalence of podoconiosis (5.06%), has been submitted to mineral analysis. High values of sulphur (S), cerium (Ce), lanthanum (La) and neodymium (Nd), typical for basaltic bedrocks, were found. Of special interest were the values for zirconium (Zr) and beryllium (Be), 618 +/- 87 ppm and 4.6 +/- 0.5 ppm respectively, twice as high as those recorded for soils sampled in neighbouring areas where the prevalence of podoconiosis is low. To be noted also, a high content in vanadium, above 250 ppm, in half of the soil samples collected in this region. Year-long exposure of unprotected feet to Zr and Be, known for their ability to induce granuloma formation in the lymphoid tissue of man, and present in a clay rich in colloidal silica particle, highly abrasive to skin, is doubtlessly a factor involved in the development of lymph node sclerosis leading to elephantiasis.
authors.affiliation: Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.
authors.forename: D
authors.initials: D
authors.lastname: Frommel
authors.forename: B
authors.initials: B
authors.lastname: Ayranci
authors.forename: H R
authors.initials: HR
authors.lastname: Pfeifer
authors.forename: A
authors.initials: A
authors.lastname: Sanchez
authors.forename: A
authors.initials: A
authors.lastname: Frommel
authors.forename: G
authors.initials: G
authors.lastname: Mengistu
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001608:Beryllium / Q000009:adverse effects* / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004604:Elephantiasis / Q000139:chemically induced* / Q000453:epidemiology*; D004781:Environmental Exposure; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D006306:Health Surveys; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012111:Residence Characteristics; D017678:Sex Distribution; D012987:Soil / Q000032:analysis*; D015040:Zirconium / Q000009:adverse effects* / Q000032:analysis*
chemical_list: D012987:Soil; D015040:Zirconium; D001608:Beryllium