title: NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide.
abstract: Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, L-arginine did not augment and L-Nv-nitroarginine did not diminish NMDA-evoked adenosine release. It appears, therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.
authors.affiliation: Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
authors.forename: C G
authors.initials: CG
authors.lastname: Craig
authors.forename: T D
authors.initials: TD
authors.lastname: White
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology*; D009569:Nitric Oxide / Q000096:biosynthesis*; D019335:Nitroarginine; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009599:Nitroprusside; D019335:Nitroarginine; D009569:Nitric Oxide; D016202:N-Methylaspartate; D001120:Arginine; D000241:Adenosine