[Amplification of int-2 gene in primary esophageal carcinoma and fetal esophageal carcinoma induced by N-methyl-N-benzylnitrosamine (NMBzA)].
Amplification of int-2 gene in primary esophageal carcinomas and adjacent tissues, fetal esophageal carcinoma induced by NMBzA and in fetal esophageal epithelium treated with NMBzA was detected. Amplification of int-2 gene was observed in 23 of 52 esophageal carcinoma (44.2%), 7 of 18 adjacent tissues (38.9%). We also found that the amplification of int-2 in fetal esophageal carcinoma induced by NMBzA and in fetal esophageal epithelium treated with NMBzA for 1 month. These results demonstrate that NMBzA activates possibly the int-2 in human esophageal epithelium to induced the esophageal carcinoma, indicating that the NMBzA may play an important role in the development of esophageal cancer.
Guo
Y J
YJ
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000235:genetics; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000235:genetics*; D005333:Fetus; D005784:Gene Amplification; D006801:Humans; D011519:Proto-Oncogenes / Q000235:genetics*
C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine