Effects of non-opioid antitussives on hypoxia-induced electrical changes in rat hippocampal slices: a comparative study with anticonvulsant drugs.
1. The effects of the non-opioid antitussives caramiphen and carbetapentane and of the anticonvulsants 5,5-diphenylhydantoin and MK 801 were tested towards hypoxia-induced electrical changes in rat hippocampal slices. 2. The incidence of appearance of hypoxia-induced epileptiform bursting was significantly decreased (P < 0.05) by carbetapentane (50-100 microM), caramiphen (50-100 microM), 5,5-diphenylhydantoin (25-50 microM), and the glutamate antagonist dizocilpine (MK 801, 25-50 microM). 3. The incidence of reappearance of the CA1 population spike after hypoxia was significantly increased (P < 0.05) by carbentapentane (50-100 microM), caramiphen (50-100 microM), 5,5-diphenylhydantoin (25-50 microM), and MK 801 (25-50 microM). 4. The results suggest a useful role for non-opioid antitussives and some anticonvulsants in the treatment of hypoxia-induced functional disturbances.
Domenici
M R
MR
Pharmacology Department, Istituto Superiore di Sanita, Roma, Italy.
Sagratella
S
S
Frank
C
C
Scotti de Carolis
A
A
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000996:Antitussive Agents / Q000494:pharmacology*; D003517:Cyclopentanes / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004594:Electrophysiology; D004827:Epilepsy / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D000996:Antitussive Agents; D003517:Cyclopentanes; C018861:carbetapentane; D010672:Phenytoin; D016291:Dizocilpine Maleate; C004519:caramiphen