Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model.
CDF1 mice were allowed to breathe either oxygen, carbogen or different concentrations of carbon monoxide gas. These treatments significantly altered the percentage of clonogenic hypoxic cells in a C3H mouse mammary carcinoma and these changes were found to correlate with direct measurements of tumour oxygenation obtained using an Eppendorf pO2 electrode.
Horsman
M R
MR
Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus.
Khalil
A A
AA
Nordsmark
M
M
Grau
C
C
Overgaard
J
J
D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage; D015687:Cell Hypoxia; D005260:Female; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism* / Q000532:radiotherapy*; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000378:metabolism*; D012119:Respiration
D002245:Carbon Dioxide; D010100:Oxygen