title: Juxtaglomerular cell tumor of the kidney: report of two cases with a papillary pattern.
abstract: We report the clinicopathologic, immunohistochemical, and electron microscopic study of two cases of juxtaglomerular cell tumor of the kidney with a hitherto unreported dominant papillary pattern. Both tumors were associated with high blood pressure that did not respond to medical therapy, but that returned to normal after removal of the kidney. They were well delineated, tan, and had no necrosis. The cores of the papillary structures consisted of polygonal cells found to express renin by immunohistochemistry and to contain renin protogranules by electron microscopy. The papillary fronds were covered by one layer of cuboidal epithelial cells that did not stain for renin and had ultrastructural features reminiscent of the collecting duct epithelium. These tumors must be differentiated from malignant papillary tumors of the kidney, such as papillary clear cell carcinoma, transitional cell carcinoma, and collecting duct carcinoma.
authors.affiliation: Department of Pathology, L'Hôtel-Dieu de Québec, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Têtu
authors.forename: L
authors.initials: L
authors.lastname: Vaillancourt
authors.forename: J P
authors.initials: JP
authors.lastname: Camilleri
authors.forename: P
authors.initials: P
authors.lastname: Bruneval
authors.forename: L
authors.initials: L
authors.lastname: Bernier
authors.forename: R
authors.initials: R
authors.lastname: Tourigny
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology*; D000328:Adult; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D004848:Epithelium / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D012083:Renin / Q000032:analysis
chemical_list: D012083:Renin