title: Mucosal immunization with a subunit respiratory syncytial virus vaccine in mice.
abstract: The protective efficacy of mucosal immunization with purified respiratory syncytial virus (RSV) fusion protein (F) using cholera toxin (CT) as an adjuvant was assessed in mice. Intranasal vaccination with F+CT induced F-specific serum IgG and nasal IgA and resulted in 75% protection from nasal virus replication compared with control mice. Intranasal CT+F with simultaneous parenteral F provided complete protection equivalent to intranasal live virus immunization.
authors.affiliation: Department of Medicine, Rochester General Hospital, NY.
authors.forename: E E
authors.initials: EE
authors.lastname: Walsh
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000287:Administration, Topical; D000818:Animals; D002772:Cholera Toxin / Q000276:immunology; D005260:Female; D015707:HN Protein; D007114:Immunization; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008954:Models, Biological; D009297:Nasal Mucosa / Q000276:immunology / Q000382:microbiology; D012136:Respiratory Syncytial Viruses / Q000276:immunology* / Q000502:physiology; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D015707:HN Protein; D046911:Macromolecular Substances; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins; D014764:Viral Proteins; D014765:Viral Vaccines; C116204:attachment protein G; D002772:Cholera Toxin