title: Intracranial calcification in siblings with nephrogenic diabetes insipidus: CT and MRI.
abstract: Computed tomography and magnetic resonance imaging (MRI) were used to examine three male siblings with nephrogenic diabetes insipidus (NDI). The two elder brothers had varying degrees of unusual intracranial calcification; the eldest also showed involvement of the cerebral white matter on MRI. The severity of intracranial calcification was related to the time before initiation of treatment and inversely to mental ability. Brain damage and mental retardation in NDI may be caused by a delay in initiating treatment; early detection and treatment are important to prevent brain damage.
authors.affiliation: Division of Child Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Tohyama
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: T
authors.initials: T
authors.lastname: Koeda
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Takeshita
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis / Q000235:genetics*; D002114:Calcinosis / Q000175:diagnosis / Q000235:genetics*; D002675:Child, Preschool; D003919:Diabetes Insipidus / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010375:Pedigree; D014057:Tomography, X-Ray Computed; D014883:Water-Electrolyte Imbalance / Q000175:diagnosis / Q000235:genetics