Ultrastructural changes in rat mammotropes following incubation with dopamine.
Cultured mammotropes incubated with dopamine for one hour exhibited changes in ultrastructure indicative of actively depressed biosynthetic and secretory activity. Peripheral relocation of rough endoplasmic reticulum appeared to create a barrier to secretory granule release by exocytosis. A decrease in the numbers of secretory granules indicated a decrease in prolactin production and enhanced lysosomal activity.
Joneja
M
M
Department of Anatomy, Queen's University, Kingston, Ontario, Canada.
Reifel
C W
CW
Murphy
M L
ML
Shin
S H
SH
D000818:Animals; D002478:Cells, Cultured; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D004298:Dopamine / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000648:ultrastructure*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011388:Prolactin; D004298:Dopamine