title: Tissue reactions to endodontic materials implanted in the mandibles of guinea pigs.
abstract: Teflon, Intermediate Restorative Material, and Prisma VLC Dycal were implanted in the mandibles of 16 guinea pigs. After experimental periods of 4 and 12 weeks, the animals were killed and tissue sections were prepared. No severe inflammatory response was noted in any of the groups except for a persistence of moderate inflammation in the poorly condensed Teflon group. Bone apposition occurred in the Prisma VLC Dycal group; none-to-mild inflammation and a thin fibrous capsule characterized the IRM group; and the Teflon group had a thick fibrous encapsulation except for samples where the Teflon material appeared to be poorly condensed and dispersed into the bony tissue. In areas where the teflon was loosely condensed, chronic inflammation and active phagocytosis were seen along the surface of the material.
authors.affiliation: Department of Endodontics, State University of New York at Buffalo, School of Dental Medicine.
authors.forename: S M
authors.initials: SM
authors.lastname: Bhambhani
authors.forename: O R
authors.initials: OR
authors.lastname: Bolanos
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000633:toxicity; D003188:Composite Resins / Q000633:toxicity; D003238:Connective Tissue / Q000187:drug effects; D005549:Foreign-Body Reaction / Q000209:etiology*; D006168:Guinea Pigs; D007249:Inflammation; D008297:Male; D008334:Mandible / Q000187:drug effects; D008768:Methylmethacrylates / Q000633:toxicity; D009336:Necrosis; D010000:Osteitis / Q000139:chemically induced; D010485:Periapical Periodontitis / Q000139:chemically induced*; D010587:Phagocytosis; D011138:Polytetrafluoroethylene / Q000633:toxicity*; D019736:Prostheses and Implants / Q000009:adverse effects*; D012184:Retrograde Obturation / Q000379:methods; D012387:Root Canal Filling Materials / Q000633:toxicity*; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D003188:Composite Resins; D008768:Methylmethacrylates; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C067791:Prisma VLC Dycal; C031667:IRM cement; D011138:Polytetrafluoroethylene; D002126:Calcium Hydroxide