Major histocompatibility complex regulation of interleukin-5 production in the mouse.
Lymph node cells of CBA (H-2k), but not of BALB/c (H-2d) mice immunized epicutaneously with picryl chloride secrete interleukin (IL)-5 when stimulated with the specific antigen in vitro. The low IL-5 production in BALB/c mice persists when either picryl chloride or the unrelated antigen oxazolone are used, when the amount of antigen in vitro is varied and when a secondary response is studied. The difference in IL-5 production maps to the major histocompatibility complex (MHC) in the congenic BALB/b, BALB/c and BALB/k mice. Furthermore, lymph node cells from (k x d) F1 mice produce IL-5 when stimulated by antigen presented on H-2k but not on H-2d antigen-presenting cells. Finally, the low IL-5 production in vitro in BALB/c mice is correlated with low picryl-specific IgA levels in vivo, which otherwise are ten times greater in CBA and BALB/k mice. The influence of MHC on IL-5 production and IgA secretion in the mouse might be a possible basis for the association of MHC with IgA deficiency in humans.
Dieli
F
F
Institute of General Pathology, University of Palermo, Italy.
Sireci
G
G
Lio
D
D
Bonanno
C T
CT
Salerno
A
A
D000818:Animals; D005786:Gene Expression Regulation; D006183:H-2 Antigens / Q000235:genetics; D007070:Immunoglobulin A / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis* / Q000235:genetics*; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013045:Species Specificity
D006183:H-2 Antigens; D007070:Immunoglobulin A; D015848:Interleukin-5