Catastrophic vasoconstriction after protamine reversal of heparin anticoagulation in the goat.
Catastrophic pulmonary vasoconstriction after protamine reversal of heparin anticoagulation was observed frequently in goats that underwent centrifugal biventricular bypass pump implant. Care should be taken when protamine is used to reverse heparin anticoagulation in goats.
Tominaga
R
R
Department of Biomedical Engineering and Applied Therapeutics, Cleveland Clinic Foundation, Ohio.
Smith
W A
WA
Harasaki
H
H
Golding
L A
LA
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006041:Goats; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D008168:Lung / Q000098:blood supply; D011479:Protamines / Q000633:toxicity*; D014661:Vasoconstriction / Q000187:drug effects*
D011479:Protamines; D006493:Heparin