title: Ten years' experience of renal transplantation in children in the cyclosporine era.
abstract: Sixty renal transplantations were performed in 53 children, 0.4-16.0 years of age during the last 10 years. Fifty-five percent of the children were < or = 7 years at transplantation and 23% were < or = 2 years. Congenital nephropathies were the primary disease in 79%. Preemptive transplantation was performed in 24 first transplantations. Forty-two grafts came from living related donors and 18 came from cadaveric donors. The 1- and 5-year patient survival rates in the 0- to 7.0-year age group were 83% and 83%, respectively, and in the 7.1- to 16.0-year age group, 100% and 93%. The 1- and 5-year graft survival rates were 77% and 77% and 90% and 74% in the two groups, respectively. In children < or = 2 years old at transplantation, the 1- and 5-year patient and graft survival rates were the same, 86% and 86% in living related donors recipients, whereas they were 40% and 40% in cadaveric donors recipients. Six patients died, 3 with functioning grafts. An additional 7 grafts were lost in 6 patients, all of whom were subsequently retransplanted. The median height SD scores at transplantation was -2.98 SD in children with congenital diseases and -0.48 SD in children with acquired diseases. The median height SD scores of the 22 children followed for 3 years after transplantation was -1.06 SD. It is concluded that the survival rates obtained are satisfactory, despite the fact that the majority of the children were transplanted at a comparatively young age because of a high frequency of congenital renal disorders.
authors.affiliation: Department of Pediatrics, Huddinge Hospital, Karolinska Institute, Sweden.
authors.forename: M S
authors.initials: MS
authors.lastname: Englund
authors.forename: U B
authors.initials: UB
authors.lastname: Berg
authors.forename: A B
authors.initials: AB
authors.lastname: Bohlin
authors.forename: A
authors.initials: A
authors.lastname: Tibell
authors.forename: G
authors.initials: G
authors.lastname: Tydén
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006128:Growth; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007223:Infant; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D011183:Postoperative Complications / Q000628:therapy
chemical_list: D016572:Cyclosporine