[Ornithine decarboxylase (ODC) activity in the mucosa of human remnant stomach, and the clinical significance on tumor promotion].
Ornithine Decarboxylase (ODC) is the most important and rate-determining enzyme in the biosynthetic pathway of polyamines which have received attention as potential indicators for neoplastic diseases. Here I report my results of the ODC activity in biopsy specimens of the mucosa from the remnant stomach in 45 cases followed closely within twenty years after the initial gastrectomy. I found that the mucosa at the anastomotic region showed higher ODC activity than that from any other region (p < 0.01). In all 20 cases which had undergone reconstruction Billroth II, the mucosa at the anastomotic region showed higher ODC activities than from the 20 cases which had undergone Billroth I (p < 0.05). Furthermore, the mucosa after Billroth II showed a gradually increasing mean ODC activity with time. Histologically, I found atrophy of the glands with foveolar hyperplasia more in the anastomotic region than in any other part of the remnant stomach (p < 0.001) and more so in those cases of Billroth II. These results suggest mucosal ODC activity may be a useful and effective biological indicator of the risk of carcinogenesis in the human remnant stomach.
Yasumoto
K
K
First Department of Surgery, Kurume University School of Medicine, Japan.
D000368:Aged; D001284:Atrophy; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D012306:Risk; D013274:Stomach Neoplasms / Q000209:etiology
D009955:Ornithine Decarboxylase