title: Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant.
abstract: We recently encountered a previously healthy 3-year-old girl who had severe bleeding resulting from a severe deficiency of prothrombin. A lupus anticoagulant was identified by several different methods. The patient was successfully treated with glucocorticoids. This rare complication of a lupus anticoagulant should be considered in the differential diagnosis of a previously well child who suddenly has hemorrhage.
authors.affiliation: University of Texas Southwestern Medical Center at Dallas.
authors.forename: J C
authors.initials: JC
authors.lastname: Bernini
authors.forename: G R
authors.initials: GR
authors.lastname: Buchanan
authors.forename: J
authors.initials: J
authors.lastname: Ashcraft
mesh_terms: D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006470:Hemorrhage / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D016682:Lupus Coagulation Inhibitor / Q000097:blood*
chemical_list: D005938:Glucocorticoids; D016682:Lupus Coagulation Inhibitor