A dose-response study of dextrorphan in permanent focal ischemia.
The dose-response curve and time window of efficacy for dextrorphan in permanent focal brain ischemia leading to infarction was studied in the rat. With pretreatment, the maximum effective dose of 20 mg/kg reduced the eventual infarct volume by greater than 50%. Delayed drug administration, up to 45 min following permanent middle cerebral artery occlusion, significantly reduced infarct size.
Graham
S H
SH
Department of Neurology, Veterans' Administration Medical Center, San Francisco, CA.
Chen
J
J
Simon
R P
RP
D000704:Analysis of Variance; D000818:Animals; D001479:Basal Ganglia / Q000276:immunology / Q000378:metabolism; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D002536:Cerebral Arteries / Q000502:physiology; D002544:Cerebral Infarction / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D003917:Dextrorphan / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D016202:N-Methylaspartate / Q000378:metabolism; D051381:Rats
D003917:Dextrorphan; D016202:N-Methylaspartate