Possible involvement of nitric oxide in arginine-induced analgesia.
Intracerebroventricular injection (icv) of 1-arginine (Arg, 0.5, 5.0, 50 micrograms) produced a dose-dependent prolongation in the hot-plate latency in mice. A similar result was obtained when nitroprusside (0.1, 1.0, 10 micrograms, icv) was given. Naloxone (2 mg.kg-1, ip) failed to antagonize the effects of Arg or nitroprusside. But Arg-induced antinociception was attenuated by NG-monomethyl-arginine (NMMA, 10 micrograms). 8-Bromoguanosine 3': 5' cyclic monophosphate (bromo-cGMP, 50 micrograms) also produced an antinociceptive effect. The results suggest that Arg induces an analgesia possibly via activation of nitric oxide-cGMP pathway.
Ji
X Q
XQ
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Zhu
X Z
XZ
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology*; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects*; D019323:omega-N-Methylarginine
D000700:Analgesics; D009599:Nitroprusside; D019323:omega-N-Methylarginine; C016276:8-bromocyclic GMP; D009569:Nitric Oxide; D001120:Arginine; D006152:Cyclic GMP