A comparative study of cyclosporine and its derivative SDZ IMM-125 in canine renal allografts.
The immunosuppressive efficacy of CsA and its derivative SDZ IMM-125 was compared in highly mismatched mongrel dogs in receipt of renal allografts. At an equal dose of 15 mg/kg/day and in the same drug vehicle, SDZ IMM-125 was not superior to CsA in prolonging allograft survival. Whole blood levels of SDZ IMM-125 were lower than those achieved for CsA. No specific drug-related side effects were noticed in this model.
Watson
C J
CJ
University Department of Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom.
Metcalfe
S M
SM
St John Collier
D G
DG
Calne
R Y
RY
D000818:Animals; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000097:blood / Q000627:therapeutic use* / Q000633:toxicity; D003524:Cyclosporins / Q000097:blood / Q000627:therapeutic use* / Q000633:toxicity; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008297:Male; D014184:Transplantation, Homologous
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine; C075935:SDZ IMM 125