Comparative effect of synthetic aminoestrogens with estradiol on platelet aggregation.
The in vitro effect upon platelet aggregation of estradiol and synthetic estrogens (prolame, buame, and proacame) is described. Prolame and buame produced a dose-dependent inhibition on platelet aggregation. Estradiol and proacame did not show anti-aggregating effects. The results suggest that the use of prolame and buame in estrogen therapy could reduce the risk of thrombo-embolic accidents.
De la Peña
A
A
Instituto Nacional de Cardiología Ignacio Chávez, Departmento de Hemantología, México, D.F.
Baños
G
G
Izaguirre
R
R
Mandoki
J J
JJ
Fernández
J M
JM
D000328:Adult; D004958:Estradiol / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000494:pharmacology*; D004962:Estranes / Q000494:pharmacology; D004963:Estrenes / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D045166:Estradiol Congeners; D004962:Estranes; D004963:Estrenes; D010975:Platelet Aggregation Inhibitors; C083898:proacame; C083897:buame; D004958:Estradiol; C047867:prolame