title: [Comparative aspects of the use of dalargin in comprehensive anesthesiologic protection during the surgical correction of congenital heart disease].
abstract: The use of graded infusion of dalargin (a home-made synthetic analogue of leu-enkephalin) in a complex of anesthesiological protection has been analysed in patients with radical correction of tetralogy of Fallot and atrial septal defect. It has been shown that delargin has a pulmonoprotective effect, moreover, it is supposed to possess a certain analgetic activity. Dalargin reduces total pulmonary resistance, the normalizing effect of the drug on the vascular tone and the degree of pulmonoprotecive action being higher in cases when the preceding pathological shifts were more pronounced. The author believes it is indicated to apply the drug in a complex of anesthesiological protection during radical correction of tetralogy of Fallot and atrial septal defect primarily to ensure intraoperative pulmonoprotection and optimization of the vascular tone in the pulmonary artery.
authors.forename: V V
authors.initials: VV
authors.lastname: Likhvantsev
authors.forename: V I
authors.initials: VI
authors.lastname: Smirnova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Kuznetsov
authors.forename: A I
authors.initials: AI
authors.lastname: Peretrukhin
authors.forename: F F
authors.initials: FF
authors.lastname: Kakurin
authors.forename: A N
authors.initials: AN
authors.lastname: Grin'ko
mesh_terms: D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D002648:Child; D003975:Diazepam; D004329:Droperidol; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005260:Female; D005283:Fentanyl; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016308:Enkephalin, Leucine-2-Alanine; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
vernacular_title: Sravnitelńye aspekty primeneniia dalargina v komplekse anesteziologicheskoĭ zashchity pri khirurgicheskoĭ korrektsii vrozhdennykh porokov serdtsa.