Preventing asthma epidemics due to soybeans by dust-control measures.
BACKGROUND
The inhalation of soybean dust released during the unloading of soybeans into a silo caused outbreaks of asthma in Barcelona, Spain. This study was designed to determine morbidity due to asthma and serum IgE reactivity before and after the installation of filters in the silo.


METHODS
We measured soybean-allergen concentrations in 136 samples of air collected for 9 months before and 24 months after the installation of filters. We compared the number of days on which there was an unexpected increase in emergency room visits for asthma, the number of days on which the number of emergency room visits for asthma in one four-hour period was so high that it was unlikely to be due to chance, and the mean daily number of emergency room and intensive care unit admissions for asthma for a total of 60 months before and after filter installation. Serum IgE antibodies against soybean allergens were measured in 38 patients before and after filter installation.


RESULTS
The concentration of airborne soybean allergens on days when soybeans were unloaded decreased from 324 to 25 U per cubic meter after the installation of filters (P < 0.001). The number of days on which there was an unusually large number of visits to the hospital for asthma and the number of days on which asthma was epidemic both decreased significantly (both P < 0.001), from 29 to 6 and from 18 to 0, respectively. The mean daily number of emergency room and intensive care unit admissions for asthma on days when soybeans were unloaded decreased from 8.3 to 5.4 and from 0.26 to 0.01, respectively (both P < 0.001). The mean serum IgE antibody concentrations in the 38 patients studied decreased from 2 Pharmacia reference units per milliliter to 1 (P < 0.001).


CONCLUSIONS
Installing filters on silos to prevent airborne dissemination of allergenic soybean dust eliminates outbreaks of asthma caused by inhalation of the dust, thus supporting the idea that the avoidance of allergens helps prevent asthma.
Antó
J M
JM
Department d'Epidemiologia i Salut Pública, Institut Municipal d'Investigació Mèdica, Barcelona, Spain.
Sunyer
J
J
Reed
C E
CE
Sabrià
J
J
Martínez
F
F
Morell
F
F
Codina
R
R
Rodríguez-Roisín
R
R
Rodrigo
M J
MJ
Roca
J
J
D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D001249:Asthma / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D004196:Disease Outbreaks / Q000517:prevention & control*; D004391:Dust / Q000009:adverse effects* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D013025:Glycine max / Q000276:immunology; D013030:Spain / Q000453:epidemiology
D000393:Air Pollutants; D004391:Dust; D007073:Immunoglobulin E