title: Demineralized bone matrix. Enhancement of spinal fusion.
abstract: A study was conducted to determine the ability of demineralized bone matrix gel to act as an osteoconductive/osteoinductive material to enhance canine spinal fusion. Seven dogs underwent posterior spinal fusion. Four-level fusions were performed with one of four procedures at each level: decortication alone, with gel added, with autograft, or with both gel and autograft. Dogs were killed at 6 weeks and early histologic response was studied. At untreated control sites, little bone formation was evident. Gel-filled sites showed abundant osteoid, with 60% of demineralized particles fused to or surrounded by new bone. Sites filled with autograft had more new bone, but there was more osteoid at gel-treated sites. Autograft augmented with gel showed the most vigorous response, with extensive bridging between demineralized particles, host bone, autograft, and new bone. Significantly less autograft was needed to induce a similar amount of new bone formation when gel was added. Use of the gel as an autograft extender may improve the chance for successful spinal fusion.
authors.affiliation: Hospital for Joint Diseases Orthopaedic Institute, New York, New York.
authors.forename: S R
authors.initials: SR
authors.lastname: Frenkel
authors.forename: R
authors.initials: R
authors.lastname: Moskovich
authors.forename: J
authors.initials: J
authors.lastname: Spivak
authors.forename: Z H
authors.initials: ZH
authors.lastname: Zhang
authors.forename: A B
authors.initials: AB
authors.lastname: Prewett
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D001862:Bone Resorption; D016025:Bone Transplantation; D002113:Calcification, Physiologic; D004285:Dogs; D005782:Gels; D008297:Male; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D011184:Postoperative Period; D011859:Radiography; D013123:Spinal Fusion / Q000379:methods*; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology; D014182:Transplantation, Autologous
chemical_list: D005782:Gels