Immunologic parameters 2 years after high-titer measles immunization in Peruvian children.
Immunization with high-titer measles vaccines has been associated with excess mortality in children 2-4 years after vaccination. In this study, immunologic parameters in 64 Peruvian children who had been immunized an average of 27 months earlier with high-titer vaccines were compared with parameters in 76 recipients of low-titer vaccines. Delayed-type hypersensitivity, lymphocyte phenotype distributions by flow cytometry, and lymphoproliferation after phytohemagglutinin (PHA) stimulation were assessed. High-titer recipients had smaller indurations to tetanus, diphtheria, and Proteus (P < .05) antigens, decreased PHA stimulation (P = .04), and a lower percentage of CD4+ lymphocytes (P = .04) than low-titer recipients. After adjustment for sex, concurrent illnesses, and other variables in regression analyses, high-titer recipients had a lower percentage of CD4+ lymphocytes (P = .025) and decreased lymphocyte proliferation to PHA (P = .058). These results may provide a clue to the pathogenesis of delayed excess mortality after high-titer measles vaccination in some developing countries.
León
M E
ME
Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.
Ward
B
B
Kanashiro
R
R
Hernández
H
H
Berry
S
S
Vaisberg
A
A
Escamilla
J
J
Campos
M
M
Bellomo
S
S
Azabache
V
V
D002455:Cell Division; D002675:Child, Preschool; D003906:Developing Countries; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007223:Infant; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008457:Measles / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D010568:Peru / Q000453:epidemiology; D012727:Sex Characteristics; D016176:T-Lymphocyte Subsets; D014611:Vaccination / Q000401:mortality
D008458:Measles Vaccine