Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension.
OBJECTIVE
It has been hypothesized that risk factors for coronary heart disease in men are linked and that the underlying factor linking them may be an alteration in the sex hormone milieu. As a test of this hypothesis, sex hormones and fibrinogen, factor VII and plasminogen activator inhibitor (PAI-1), hemostatic factors recently shown to be risk factors for myocardial infarction, were measured in men with hypertension and in healthy control subjects.


RESULTS
The fasting serum testosterone and free testosterone levels were decreased and the plasma factor VII and PAI-1 levels increased in the men with hypertension.


CONCLUSIONS
These findings are consistent with the stated hypothesis.
Phillips
G B
GB
Department of Medicine, Columbia University College of Physicians and Surgeons, St Luke's-Roosevelt Hospital Center, New York, New York.
Jing
T Y
TY
Resnick
L M
LM
Barbagallo
M
M
Laragh
J H
JH
Sealey
J E
JE
D001779:Blood Coagulation Factors / Q000032:analysis*; D003327:Coronary Disease / Q000209:etiology*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood
D001779:Blood Coagulation Factors; D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone