The effect of carbamazepine on endocrine and sleep EEG variables in a patient with 48-hour rapid cycling, and healthy controls.
Carbamazepine treatment of a patient with 48-hour rapid cycling led to a dampening of mood cycling, and prolonged rapid eye movement (REM) sleep latency. No effect on central alpha-receptors as measured by growth hormone (GH) secretion after clonidine stimulation or on spontaneous 48-hour GH secretion was observed. In 12 healthy subjects given 400 mg carbamazepine daily for a period of 5 days, improved sleep continuity and increased slow-wave sleep occurred with treatment. REM sleep percentage and REM latency remained uninfluenced, whereas REM density decreased. GH secretion after clonidine stimulation was not altered. Data from the single-case longitudinal study emphasize that carbamazepine is effective in treating rapid-cycling affective psychosis. Furthermore, neuroendocrine and sleep EEG data from the study in healthy subjects indicate a different profile of action for carbamazepine compared to most other antidepressants or antimanic drugs.
Riemann
D
D
Central Institute of Mental Health, Mannheim, FRG.
Gann
H
H
Hohagen
F
F
Bahro
M
M
Müller
W E
WE
Berger
M
M
D000328:Adult; D000339:Affect / Q000187:drug effects; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D002220:Carbamazepine / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D003000:Clonidine; D004569:Electroencephalography / Q000187:drug effects*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D006728:Hormones; D002220:Carbamazepine; D003000:Clonidine