Reversal of diastolic dysfunction by intravenous magnesium chloride.
OBJECTIVE
To treat diastolic dysfunction in patients with coronary artery disease (CAD).


METHODS
Open study of the intravenous injection of 5 mL of a solution containing 17% magnesium chloride (equal to 100 mg of elemental magnesium) during routine coronary angiography in patients with a raised left ventricular end-diastolic pressure (LVEDP).


METHODS
A hospital department of cardiac hemodynamics.


METHODS
Ten patients with angiographically documented CAD.


RESULTS
After magnesium chloride injection, the LVEDP was significantly reduced in all patients, from a mean of 24 +/- 3 to 16 +/- 3 mmHg (P < 0.001).


CONCLUSIONS
Under the short term conditions of the study, the injection of magnesium chloride effectively improved left ventricular diastolic function. Further study of the long term effect is required.
Kraus
F
F
D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects*; D005260:Female; D006801:Humans; D015636:Magnesium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*
D015636:Magnesium Chloride