Different mode of action of endothelin-1 in parietal and visceral veins.
The mode of contractile effect of endothelin-1 in venous smooth muscles was evaluated using three isolated veins, the jugular vein, the portal vein and the inferior caval vein of dogs. The contractile responses to endothelin-1 were attenuated by atropine and augmented by neostigmine in the inferior caval and portal veins, but were not affected by either agent in the jugular vein. We conclude that the contractile responses of visceral veins to endothelin-1 are partly mediated via endogenously released acetylcholine.
Hayakawa
A
A
Department of Anesthesiology, Nagoya University School of Medicine, Japan.
Kawanishi
M
M
Ishikawa
N
N
Shimada
Y
Y
Goto
K
K
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007601:Jugular Veins / Q000187:drug effects* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D009388:Neostigmine / Q000494:pharmacology; D011169:Portal Vein / Q000187:drug effects* / Q000502:physiology; D014682:Vena Cava, Inferior / Q000187:drug effects* / Q000502:physiology
D016232:Endothelins; D009388:Neostigmine; D001285:Atropine