title: The effect of cimetidine on verruca plana juvenilis: clinical trials in six patients.
abstract: Cimetidine is an H2-receptor antagonist which is mainly used to treat gastrointestinal diseases. Recently, many authors have suggested that cimetidine has the ability to reverse acquired tolerance to dinitrochlorobenzene (DNCB). We have used cimetidine in six patients with verruca plana who showed no therapeutic response to DNCB. Four of them responded and showed complete disappearance of the verruca plana. The mean duration of oral cimetidine administration (1.2 g/day) was 4 weeks until the disappearance. Therefore, we suggest that oral cimetidine can be used as an effective and safe adjunctive modality for the treatment of verruca plana.
authors.affiliation: Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Choi
authors.forename: S K
authors.initials: SK
authors.lastname: Hann
authors.forename: Y K
authors.initials: YK
authors.lastname: Park
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004137:Dinitrochlorobenzene; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D017193:Skin Diseases, Viral / Q000188:drug therapy*; D014860:Warts / Q000188:drug therapy*
chemical_list: D004137:Dinitrochlorobenzene; D002927:Cimetidine