Postmortem serum selenium concentrations and their possible etiological role in sudden infant death (SID).
The importance of selenium (Se) deficiency in the pathogenesis of human diseases such as Keshan Disease has been extensively studied. It is possible that low Se-levels could cause immunosuppression and be an etiological factor in Sudden Infant Death (SID). We investigated 50 serum samples (40 SID and 10 non-SID victims) by atomic absorption spectrometry. The results show that there is no evidence of a serum selenium deficiency in SID-victims in the region of Aachen. A relationship between selenium concentration and the infant immune system still remains speculative and 21 samples even showed increased serum levels. It could be necessary to define a 'local' normal range by examining a greater number of healthy infants.
Lemke
R
R
Institute of Forensic Medicine, Rhein.-Westfalian Technical University (RWTH), Aachen, Germany.
Schäfer
A
A
Makropoulos
W
W
D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D008297:Male; D012016:Reference Values; D012643:Selenium / Q000097:blood*; D013398:Sudden Infant Death / Q000276:immunology / Q000473:pathology*
D012643:Selenium