[Neurotransplantations: experimental studies].
Before the intracerebral transplantations of adrenal medulla and fetal substantia nigra in parkinsonian patients were introduced to restore the dopamine deficit, many intensive experimental studies were performed during the last decades. The history of these experiments was presented including the animal models of Parkinson's disease, different implantation techniques and the effects of neurotransplantations of adrenal medulla and fetal substantia nigra obtained in experimental animals. Different mechanisms underlying the transplant-induced functional effects as well as the methods of its stimulation to extend the graft survival and function were described. The ability of intracerebral transplantations to ameliorate the symptoms in animal models of disorders other than Parkinson's disease is also discussed.
Dymecki
J
J
Zakładu Neuropatologii Instytutu Psychiatrii i Neurologii, Warszawie.
D000313:Adrenal Medulla / Q000601:surgery* / Q000637:transplantation*; D000818:Animals; D001921:Brain / Q000503:physiopathology; D016380:Brain Tissue Transplantation; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D011954:Receptors, Dopamine; D013378:Substantia Nigra / Q000637:transplantation
D011954:Receptors, Dopamine
Neurotransplantacje. I. Podstawy doświadczalne.