A case of severe IgA nephropathy associated with psoriatic arthritis and idiopathic interstitial pneumonia.
A patient is described with severe IgA nephropathy associated with psoriatic arthritis, idiopathic interstitial pneumonia and brain hemorrhage that developed serially over one and a half years. The histological findings of the renal biopsy showed severe endo- and extracapillary proliferative glomerulonephritis. Massive IgA deposits were observed by immunofluorescence not only in the mesangium but also along the capillary walls. Electron microscopy revealed abundant electron-dense deposits in the mesangial and subendothelial areas. The overlapping or coexistence of these conditions has rarely been reported.
Hiki
Y
Y
Department of Medicine, School of Nursing and Medicine, Kitasato University, Sagamihara, Japan.
Kokubo
T
T
Horii
A
A
Yokouchi
S
S
Satoh
M
M
Kuwao
S
S
Shigematsu
H
H
Kobayashi
Y
Y
D000328:Adult; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D002543:Cerebral Hemorrhage / Q000150:complications; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology
D007070:Immunoglobulin A