title: Contribution of calcium ions to the generation of epileptic activity and antiepileptic calcium antagonism.
abstract: With epileptic activity, neurons show paroxysmal depolarization shifts (PDSs) corresponding to epileptic field potentials (EFPs) generated by the neuronal population. Experimental results indicate that calcium and calcium-dependent currents participate in the generation of these events. Consequently neuronal PDS/EFP were depressed by organic calcium channel blockers. This justifies the hope that calcium channel blockers might be useful in the treatment of human epilepsies.
authors.affiliation: Institut für Physiologie, Münster, FRG.
authors.forename: E J
authors.initials: EJ
authors.lastname: Speckmann
authors.forename: H
authors.initials: H
authors.lastname: Straub
authors.forename: R
authors.initials: R
authors.lastname: Köhling
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans
chemical_list: D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D002118:Calcium