[Monocyte aggregation as a criterion in the evaluation of mononuclear phagocytes function in patients with bronchial asthma].
The study was made of arachidonate-induced aggregation of peripheral blood monocytes in 18 patients with bronchial asthma versus 12 controls. Monocytic aggregation and dependence of the patients on glucocorticosteroids appeared related: in hormones untreated patients the aggregation was more active than in controls. The aggregation of hormone-dependent patients and controls showed no significant differences. Allergic reaction correlated in severity to aggregation intensity. The method of graphic registration of arachidonate-induced aggregation of peripheral blood monocytes is promising in evaluation of immunity macrophagal-monocytic component in asthmatic patients.
Gembitskiĭ
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EV
Fesenko
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OV
Kubatiev
A A
AA
D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D016718:Arachidonic Acid / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D002449:Cell Aggregation / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*
D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D016718:Arachidonic Acid
Agregatsiia monotsitov kak kriteriĭ otsenki funktsionalńogo sostoianiia sistemy mononuklearnykh fagotsitov u bolńykh bronkhialńoĭ astmoĭ.