Hepatic cirrhosis showing false-positive serum C-reactive protein reaction.
A 58-year-old male who had been diagnosed as hepatic cirrhosis four years previously was admitted to our hospital because his serum C-reactive protein (CRP) level had gradually risen, reaching 139 mg/dl. No inflammation findings were observed subjectively or objectively. Close examination revealed his CRP reaction to be false positive. His serum CRP showed positive only in a latex agglutination method using goat anti-CRP IgG. This false-positive reaction was thought to be owing to the abnormally glycosylated IgM, which has an affinity for the goat serum IgG.
Sato
M
M
Second Department of Internal Medicine, Omori Hospital, Tokyo, Japan.
Sugimoto
M
M
Nanba
S
S
Kasatori
N
N
Urayama
T
T
D015153:Blotting, Western; D002097:C-Reactive Protein / Q000032:analysis*; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D005189:False Positive Reactions; D006801:Humans; D005779:Immunodiffusion; D007841:Latex Fixation Tests; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
D002097:C-Reactive Protein