Suppression of growth by dietary fish oil of human breast carcinomas maintained in three different strains of immune-deficient mice.
It has been reported that high levels of dietary fish (menhaden) oil, compared with corn oil, suppress the growth of MDA-MB231 and MCF-7 human breast carcinomas maintained in female athymic nude (T lymphocyte-deficient) mice. The purpose of this study was to determine whether dietary fish (menhaden) oil, compared with corn oil, can also suppress the growth of these carcinomas when maintained in female beige-XID-athymic nude (T lymphocyte- and NK/LAK cell-deficient) mice and in female severe combined immune-deficient (SCID) mice (total lack of functional T and B lymphocytes). Results clearly show that dietary fish (menhaden) oil can significantly (p < 0.05) suppress the growth of these carcinomas in the beige-XID-athymic nude mouse and the SCID mouse. Such results provide evidence that the growth suppression of MDA-MB231 and MCF-7 human breast carcinomas, induced by dietary fish oil, is not mediated by immune system mechanisms involving T lymphocytes, B lymphocytes, and/or NK/LAK cells.
Welsch
C W
CW
Department of Pharmacology/Toxicology, Michigan State University, East Lansing 48824.
Oakley
C S
CS
Chang
C C
CC
Welsch
M A
MA
D000818:Animals; D001943:Breast Neoplasms / Q000178:diet therapy* / Q000276:immunology; D003314:Corn Oil / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D009376:Neoplasms, Hormone-Dependent / Q000178:diet therapy* / Q000276:immunology; D015430:Weight Gain
D005395:Fish Oils; D003314:Corn Oil