Re-epithelialization. Human keratinocyte locomotion.
Keratinocyte migration and proliferation both play a role in covering skin wounds by the process of re-epithelialization. Connective tissue components are a powerful influence on keratinocyte locomotion. The mechanisms of keratinocyte locomotion and cellular division are independent. Both connective tissue components and soluble factors may serve to enhance keratinocyte migration. In addition to the field of growth factors, we would like to suggest that there should be the recognition of an entire new class of agents called migration factors.
Woodley
D T
DT
Department of Dermatology, Northwestern University School of Medicine, Chicago, Illinois.
Chen
J D
JD
Kim
J P
JP
Sarret
Y
Y
Iwasaki
T
T
Kim
Y H
YH
O'Keefe
E J
EJ
D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology*; D012867:Skin / Q000166:cytology / Q000293:injuries; D012879:Skin Physiological Phenomena; D014945:Wound Healing / Q000502:physiology*