Distribution of wild type 1 poliovirus genotypes in China.
Poliomyelitis remains an important public health problem in China. Most cases and outbreaks are associated with wild type 1 polioviruses. To obtain an overview of type 1 poliovirus transmission in China, partial genomic sequences were compared for 24 case isolates from 12 provinces. Because polioviruses evolve rapidly during infection of humans, the genetic relationships among isolates provide a measure of the extent of epidemiologic linkage among cases. The observed genetic relationships were complex: six different genotypes, apparently derived from five separate endemic origins, were found. One genotype was recombinant, having noncapsid sequences derived from the Sabin type 1 vaccine strain and capsid sequences derived from a genotype indigenous to several northern and eastern provinces. Some isolates from geographically separate provinces were closely related; other isolates were related to wild polioviruses found in neighboring countries. The combination of epidemiologic and virologic analyses may facilitate the development of more effective strategies for poliomyelitis eradication.
Zheng
D P
DP
Jiangxi Provincial Anti-Epidemic Station, Nanchang, China.
Zhang
L B
LB
Fang
Z Y
ZY
Yang
C F
CF
Mulders
M
M
Pallansch
M A
MA
Kew
O M
OM
D001483:Base Sequence; D002460:Cell Line; D002681:China / Q000453:epidemiology; D004279:DNA, Viral; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D011051:Poliomyelitis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D017955:Poliovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction
D004279:DNA, Viral