title: Protective action of L-carnitine and coenzyme Q10 against hepatic triglyceride infiltration induced by hyperbaric oxygen and ethanol.
abstract: This investigation was conducted to ascertain whether administration of L-carnitine and coenzyme Q10 could protect from the experimentally-induced hepatic lipid infiltration and glutathione content decrease in rats exposed to hyperbaric oxygen and prolonged alcohol administration. The results indicate that administration of L-carnitine and coenzyme Q10 in association reduces damage induced by chronic alcohol poisoning and hyperbaric oxygen. This protective action is more marked when L-carnitine and coenzyme Q10 are administered together. The combined complementary biochemical activity of these two compounds is discussed.
authors.affiliation: Department of Medical Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertelli
authors.forename: A
authors.initials: A
authors.lastname: Cerrati
authors.forename: L
authors.initials: L
authors.lastname: Giovannini
authors.forename: M
authors.initials: M
authors.lastname: Mian
authors.forename: P
authors.initials: P
authors.lastname: Spaggiari
authors.forename: A A
authors.initials: AA
authors.lastname: Bertelli
mesh_terms: D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism*; D014451:Ubiquinone / Q000494:pharmacology*
chemical_list: D008054:Lipid Peroxides; D014280:Triglycerides; D014451:Ubiquinone; D000431:Ethanol; D005978:Glutathione; C025204:Ubiquinone Q2; D002331:Carnitine