title: Cytogenetic study in idiopathic infertile males.
abstract: Sex chromatin investigations, including X-chromatin and Y-chromatin, was carried out on one hundred idiopathic infertile males with marked oligospermia or azoospermia. Seven cases (7%) were X-chromatin positive, 18% of the cases had aberrant Y-body (10% big Y, 7% small Y and 1% double Y). Such Y-chromosome abnormalities were frequent among azoospermic than oligospermic males. Chromosomal analysis of patients with positive X-chromatin and/or abnormalities of the Y-chromosome showed chromosomal abnormalities in the seven azoospermic cases (7%) which were X-chromatin positive. These chromosomal abnormalities are varieties of mosaic Klinefelter. Six patients (6%) were 46,XY/47,XXY mosaic and one patient (1%) was 46, XY/47,XXY/48,XXYY mosaic. In conclusion, chromosome analysis as well as sex-chromatin analysis is thus necessary in the investigation of male infertility.
authors.affiliation: Department of Human Genetics, Alexandria University.
authors.forename: S R
authors.initials: SR
authors.lastname: Ismail
authors.forename: A H
authors.initials: AH
authors.lastname: el-Beheiry
authors.forename: M M
authors.initials: MM
authors.lastname: Hashishe
authors.forename: M E
authors.initials: ME
authors.lastname: el-Bahaei
mesh_terms: D000328:Adult; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D012728:Sex Chromatin; D012729:Sex Chromosome Aberrations; D014998:Y Chromosome