Hyperphagia and obesity in female rats with temporal lobe lesions.
Damage to the temporal lobes in cats, dogs, and primates has long been known to result in hyperphagia and obesity, but research into the role of this area of the brain in feeding behavior has largely been neglected because of an inability to produce similar results in rats. The present study reports hyperphagia and obesity in female rats with small electrolytic lesions centered in the posterodorsal amygdala. Daily food intake more than doubled in the first few days after surgery and mean weight gain was more than four times that observed in animals with sham lesions during the first 26 days. The rats with lesions were not hyperresponsive to a switch in diets (lab chow to high-fat, and back). In all animals that gained abnormal amounts of weight, the posterior extent of the lesions extended through the amygdalohippocampal area into the ventral hippocampal formation. The results suggest that the temporal lobe is an important extrahypothalamic site for the regulation of food intake in rodents.
King
B M
BM
Department of Psychology, University of New Orleans, LA 70148.
Kass
J M
JM
Cadieux
N L
NL
Sam
H
H
Neville
K L
KL
Arceneaux
E R
ER
D000818:Animals; D001835:Body Weight / Q000502:physiology; D004435:Eating / Q000502:physiology; D005260:Female; D006963:Hyperphagia / Q000503:physiopathology*; D007031:Hypothalamus / Q000502:physiology; D009765:Obesity / Q000503:physiopathology*; D051381:Rats; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology