[The place of insulin-like growth factor I in the diagnosis of acromegaly].
Insulin-like growth factor-I (IGF-I) and basal growth hormone (GH) (average of GH values measured at -20 an 0 minutes) levels were measured in 32 (29 treated, 3 untreated) patients with acromegaly. In 15 patients IGF-I and basal GH values were normal. In 12 patients both GH and IGF-I were elevated. In 5 cases normal basal GH and elevated IGF-I levels were found. We assume that elevated serum level of IGF-I is a reliable sign of acromegalic activity. Compared to this, the basal GH level proved to be a much less reliable indicator to predict or exclude active acromegaly (sensitivity: 0.7, specificity: 1, positive predictive value: 1, negative predictive value: 0.75).
Dohán
O
O
I. Belgyógyászati Klinika, Orvostovábbképzö Egyetem.
Góth
M
M
Szabolcs
I
I
Kovács
L
L
Kovács
Z
Z
Szilágyi
G
G
D000172:Acromegaly / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
Az inzulinszerü növekedési faktor-I helye az akromegalia aktivitásának megítélésében.