title: Recent developments in alcoholism:biobehavioral correlates.
abstract: A literature review was conducted from 1940 through 1992 on the general topic of alcohol-induced hangover. We focused on the physiological, behavioral, and performance decrements demonstrated hours after a physiologically relevant dose of alcohol was administered in both humans and animals. The purpose of this report was threefold: (1) to review and report both previously published and new data from our laboratory concerning the "after effects" of acute high-dose alcohol administration; (2) to highlight the similarities between and usefulness of data generated from both human and animal studies; and (3) to propose that the hangover phenomenon may be the result of one of the three following hypotheses: (a) an opponent-process physiological rebound from alcohol's immediate, intoxicating effects, (b) some toxic reaction to alcohol or its metabolic by-products, or (c) to the circadian dysrhythmia induced by the immediate intoxicating effects of alcohol.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
authors.forename: D V
authors.initials: DV
authors.lastname: Gauvin
authors.forename: E Y
authors.initials: EY
authors.lastname: Cheng
authors.forename: F A
authors.initials: FA
authors.lastname: Holloway
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects* / Q000503:physiopathology; D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
chemical_list: D000431:Ethanol