[The effect of moderate doses of ethanol on the nature of the background neuronal impulse activity of the sensorimotor cortex in rats].
The influence of acute administration of moderate doses of ethanol (170-1200 mcg/kg, intraperitoneally) on the spontaneous impulse activity of motor cortex neurons was studied in outbred rats never earlier exposed to alcohol. Initial reactions of the cortical neurons were shown to be characterized by the changes in the frequency of spontaneous activity which could be increased or decreased during the first 20-25 min after the injection. The changes in the mean frequency of spontaneous discharges were accompanied by the changes in their patterns. Both increase and decrease of the mean frequency at the initial stage of ethanol action was accompanied by significant variability of interspike intervals. It is emphasized that examination of the initial reactions of the cortical neurons to ethanol administration demands studying their temporal duration.
Stashkevich
I S
IS
Maksimova
L N
LN
Sokolov
S S
SS
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D008838:Microcomputers; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013997:Time Factors
D000431:Ethanol
Vliianie umerennykh doz étanola na kharakter fonovoĭ impul'snoĭ aktivnosti neĭronov sensomotornoĭ kory krys.