title: Risk factors for development of rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis.
abstract: We studied 259 patients to determine the time-dependent risk and risk factors for the development of retinal detachment in patients with cytomegalovirus retinitis. The six-month and one-year retinal detachment rates (by eye) were 11% and 24%, respectively. Increasing retinal surface involvement outside of the posterior pole and the presence of retinitis activity were found to be the two covariates that best predicted retinal detachment. Eyes with peripheral involvement greater than 25% had a fivefold risk for detachment, compared to eyes with 10% involvement. If there was retinitis activity and more than 25% peripheral (external to major vascular arcades) involvement, the risk increased to 24-fold. The presence of a fellow eye with retinal detachment was not an independent risk factor. These observations should help in the design of a prophylactic trial intended to prevent retinal detachment and should also help ophthalmologists counsel patients with cytomegalovirus retinitis.
authors.affiliation: Department of Ophthalmology, University of California San Diego School of Medicine.
authors.forename: W R
authors.initials: WR
authors.lastname: Freeman
authors.forename: D N
authors.initials: DN
authors.lastname: Friedberg
authors.forename: C
authors.initials: C
authors.lastname: Berry
authors.forename: J I
authors.initials: JI
authors.lastname: Quiceno
authors.forename: M
authors.initials: M
authors.lastname: Behette
authors.forename: S C
authors.initials: SC
authors.lastname: Fullerton
authors.forename: D
authors.initials: D
authors.lastname: Munguia
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000188:drug therapy; D017726:Cytomegalovirus Retinitis / Q000150:complications* / Q000188:drug therapy; D005500:Follow-Up Studies; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications; D006801:Humans; D015994:Incidence; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012163:Retinal Detachment / Q000209:etiology*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D017245:Foscarnet; D015774:Ganciclovir