[The circadian rhythm of ciliary beat frequency of human nasal cilia in probands with healthy lungs and in patients with chronic obstructive lung disease. Includes adrenergic stimulation by terbutaline].
Brush biopsies taken from the human nose eight times during 24 hours were examined under a phase contrast microscope and the ciliary beat frequency was measured directly by a photosensitive cell. Ten healthy volunteers showed in two series of measurements, at 600, 1200, 1800, 2400 initially and 300, 900, 1500, 2100 six weeks later, a marked decrease in ciliary beat frequency towards the middle of the day and a statistically higher beat frequency in the early morning. The influence of the adrenergic drug terbutaline led to a cilioexcitation ranging from 0.1-1.4 Hz (mean: 0.9 Hz). In contrast to, neither a circadian variation of the ciliary beat frequency nor a stimulation by terbutaline could be observed in a group of fifteen patients with chronic bronchitis or bronchiectasis at 600, 1200, 1800 and 2400.
Thomas
A
A
Ruhrlandklinik, Zentrum für Pneumologie und Thoraxchirurgie, Essen-Heidhausen.
Petro
W
W
Konietzko
N
N
D000328:Adult; D002923:Cilia / Q000187:drug effects / Q000502:physiology*; D002925:Ciliary Motility Disorders / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects / Q000503:physiopathology; D012016:Reference Values; D013726:Terbutaline
D013726:Terbutaline
Untersuchungen zur zirkadianen Rhythmik der Schlagfrequenz menschlicher Nasenzilien bei Lungengesunden und Patienten mit chronisch obstruktiver Lungenerkrankung. Einschliesslich der adrenergen Stimulation durch Terbutalin.