Fundus pigmentation and the electroretinographic luminance-response function.
Dark-adapted and light-adapted electroretinographic luminance-response functions were recorded from subjects with light or dark fundus pigmentation based on digitized fundus photographs. For dark- and light-adapted electroretinograms, subjects with dark fundi had smaller b-wave amplitudes at all luminance levels. There was no significant difference in b-wave implicit time for the dark-adapted electroretinogram, but there was a significant difference for the light-adapted ERG between the two groups. The results suggest that fundus pigmentation should be considered in the interpretation of electroretinogram results. A possible mechanism for the influence of fundus pigmentation on b-wave amplitude is based on increased resistance associated with melanin.
Wali
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Department of Ophthalmology, Columbus Children's Hospital.
Leguire
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LE
D000328:Adult; D003623:Dark Adaptation; D004596:Electroretinography; D005654:Fundus Oculi; D006801:Humans; D008027:Light; D008543:Melanins / Q000502:physiology; D012160:Retina / Q000502:physiology*; D012168:Retinal Pigments / Q000502:physiology*; D012684:Sensory Thresholds
D008543:Melanins; D012168:Retinal Pigments