Model building program HLX4: application to non-classical helical structures.
The model building program HLX4 for multiple stranded helices was developed as a useful tool for understanding of the biological roles of these helices and application of nobel base pairing scheme by chemical modification. In stead of torsion angle, the helical parameter is elected as the input information to generate the starting global structure. The model building performance is threefold, first, coarse connectivity check and second, fine connectivity check and energy minimization. This program system can be successfully applied to the DNA duplex with the nobel G:A base pairing and triplex with the modified sugar moiety.
Fujii
S
S
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Yamashita
T
T
D001483:Base Sequence; D002241:Carbohydrates / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012984:Software
D002241:Carbohydrates; D004247:DNA