title: Prevention of sudden death in patients with coronary artery disease: the Multicenter Unsustained Tachycardia Trial (MUSTT).
abstract: This trial will significantly advance our understanding of the prognostic and therapeutic usefulness of electrophysiologic studies in patients with coronary artery disease. Several features of this trial are worth emphasizing. First, the protocol for performing programmed stimulation and serial drug testing is designed to mirror those currently in use by many practicing electrophysiologists. While practice patterns vary, the procedures used in the trial reflect what is considered "usual and standard" practice. Second, because half of the patients with inducible sustained ventricular tachycardia will be given no antiarrhythmic therapy, we will be able to ascertain the true risk of sudden death in this patient population without the influence of these agents. Third, this trial will assess the usefulness of a method of guiding antiarrhythmic therapy (electrophysiologic testing) to reduce mortality in this high-risk population. It will not evaluate the efficacy of a specific type of antiarrhythmic therapy.
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140.
authors.forename: A E
authors.initials: AE
authors.lastname: Buxton
authors.forename: J D
authors.initials: JD
authors.lastname: Fisher
authors.forename: M E
authors.initials: ME
authors.lastname: Josephson
authors.forename: K L
authors.initials: KL
authors.lastname: Lee
authors.forename: D B
authors.initials: DB
authors.lastname: Pryor
authors.forename: E N
authors.initials: EN
authors.lastname: Prystowsky
authors.forename: M B
authors.initials: MB
authors.lastname: Simson
authors.forename: L
authors.initials: L
authors.lastname: DiCarlo
authors.forename: D S
authors.initials: DS
authors.lastname: Echt
authors.forename: D
authors.initials: D
authors.lastname: Packer
mesh_terms: D000638:Amiodarone / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D002304:Cardiac Pacing, Artificial; D002985:Clinical Protocols; D003327:Coronary Disease / Q000150:complications* / Q000401:mortality; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D004562:Electrocardiography / Q000379:methods; D006801:Humans; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000150:complications; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000638:Amiodarone