Plasma angiotensin I concentration and serum placental leucine aminopeptidase (P-LAP) activities in puerperal hypertension.
To elucidate the involvement of angiotensin in puerperal hypertension with and without preeclampsia in the course of prior pregnancy, we measured plasma angiotensin I levels and serum placental leucine aminopeptidase (P-LAP) activities in several puerperal hypertensive patients. Placental leucine aminopeptidase (P-LAP) activities of puerperal hypertensive patients with severe preeclampsia during prior pregnancy were equal to or somewhat lower levels than those in normal puerperal women after a normal pregnancy. However, their angiotensin I levels were higher than those in normal puerperal women after a normal pregnancy. In puerperal hypertensive patients with and without preeclampsia during prior pregnancy, P-LAP activities tended to show much lower levels that those in normal puerperal women, while angiotensin I levels tended to show much higher levels than those in normal puerperal women, respectively. Since serum placental leucine aminopeptidase acts as an angiotensinase via degradation of angiotensin III (A-III), our present data suggest the involvement of angiotensin in puerperal hypertension.
Mizutani
S
S
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Tomoda
Y
Y
D000328:Adult; D000803:Angiotensin I / Q000097:blood*; D002216:Captopril / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D007931:Leucyl Aminopeptidase / Q000097:blood* / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood / Q000188:drug therapy; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood; D011644:Puerperal Disorders / Q000097:blood*; D012083:Renin / Q000097:blood
D000803:Angiotensin I; D002216:Captopril; D007931:Leucyl Aminopeptidase; D012083:Renin