title: The functional role of an increase in cell excitability and synaptic efficiency in the new cortex during learning.
abstract: Data were obtained in experiments on nonimmobilized and nonanesthetized rabbits, during the development of an analog of a CR, with recording of the response of the pyramidal tract, suggesting temporal specificity in the manifestations of membrane and synaptic plasticity, the participation of these mechanisms in both representations of the combined stimuli, and primarily unidirectional changes in the degree of their participation in these points of the cortex. It is concluded that temporary membrane plasticity creates conditions through the mechanisms of synchronization and summation for the passage of excitation from the sensory link to the motor output of the new connection. The gradual reorganization of excitatory and inhibitory connections to the output elements of the conditioned reflex act, determined by the mechanisms of synaptic plasticity, determine and strengthen the specialized character of the developed reaction.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: R G
authors.initials: RG
authors.lastname: Kozhedub
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D004558:Electric Stimulation; D005795:Generalization, Stimulus; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology; D011817:Rabbits; D013569:Synapses / Q000502:physiology*; D013570:Synaptic Membranes / Q000502:physiology; D013997:Time Factors