title: Changes of IgE production, splenic helper and suppressor T lymphocytes in mice infected with Paragonimus westermani.
abstract: Effects of Paragonims westermani infection were observed in mice on the change of serum IgE level, the number of peripheral eosinophils and the distribution of Thy 1.2+ (CD3), L3T4+ (CD4), and Lyt-2+ (CD8) splenic T lymphocytes without mitogen stimulation. BALB/c mice were infected with 20 metacercariae of P. westermani each. Total serum IgE increased at 3 weeks after the infection and reached a peak on week 4 and maintained high levels of IgE until the 23rd week. Peripheral eosinophil numbers increased at the second week and attained peak level on week 9. The frequency of L3T4+ (CD4) and Lyt-2+ (CD8) T lymphocytes decreased slightly until 4 weeks after the infection, but not significantly. Absolute number of L3T4+ and Lyt-2+ T lymphocytes, and the ratio of L3T4/Lyt-2 were not markedly changed over the period of observation. The frequency of Thy 1.2+ (CD3) T lymphocytes in the infected group slightly decreased until 4 weeks after the infection and showed significant reductions at the 2nd and 4th week of the infection (p < 0.05).
authors.affiliation: Department of Parasitology, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: D Y
authors.initials: DY
authors.lastname: Min
authors.forename: J S
authors.initials: JS
authors.lastname: Ryu
authors.forename: M H
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D003400:Astacoidea / Q000469:parasitology; D016516:CD4-CD8 Ratio; D004804:Eosinophils; D007073:Immunoglobulin E / Q000097:blood*; D007958:Leukocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C; D010237:Paragonimiasis / Q000276:immunology*; D010238:Paragonimus / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D016176:T-Lymphocyte Subsets; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
chemical_list: D000909:Antibodies, Helminth; D007073:Immunoglobulin E