title: Intravenous nicardipine in hypertensive children.
abstract: Fourteen hypertensive patients hospitalized in a paediatric intensive care unit were studied to evaluate safety and hypotensive efficacy of intravenous nicardipine. Systolic and diastolic blood pressure significantly decreased 1 h after the beginning of the treatment (1 microgram/kg per minute). Mean decrease in systolic blood pressure during the first 24 h was between 9.9% and 13.4% of the initial value. Mean lowering of diastolic blood pressure was between 16.7% and 25.6%. Nicardipine did not significantly affect heart rate with dose of 1 microgram/kg per minute. No clinical side-effects were observed. Nicardipine could be a first line drug for the treatment of hypertension in paediatric intensive care units.
authors.affiliation: Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Treluyer
authors.forename: P
authors.initials: P
authors.lastname: Hubert
authors.forename: P
authors.initials: P
authors.lastname: Jouvet
authors.forename: S
authors.initials: S
authors.lastname: Couderc
authors.forename: M
authors.initials: M
authors.lastname: Cloup
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007362:Intensive Care Units; D008297:Male; D009529:Nicardipine / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D009529:Nicardipine