title: Silver sulphadiazine: a comprehensive in vitro reassessment.
abstract: The antimicrobial activity of silver sulphadiazine has been determined agonist 409 strains from 12 different genera. MICs were usually in the range 16-64 micrograms/ml. Multi-resistant species, such as methicillin-resistant Staphylococcus aureus and Acinetobacter spp., were uniformly sensitive. MICs always exceeded the reported aqueous solubility of silver sulphadiazine. No resistant strains were found, and there was no correlation between MIC of silver sulphadiazine and resistance to sulphonamides. Time-kill experiments showed that sulphonamide-resistant S. aureus (but not Staphylococcus epidermidis) were killed significantly more slowly than were sulphonamide-sensitive strains.
authors.affiliation: Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Hamilton-Miller
authors.forename: S
authors.initials: S
authors.lastname: Shah
authors.forename: C
authors.initials: C
authors.lastname: Smith
mesh_terms: D000150:Acinetobacter / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012837:Silver Sulfadiazine / Q000494:pharmacology*; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*
chemical_list: D012837:Silver Sulfadiazine