Oligomycin F, a new immunosuppressive homologue of oligomycin A.
Oligomycin F, a new homologue of oligomycin A (1), was isolated from a Streptomyces species and structure 2 was deduced by NMR methods. Compound 2 is highly active against plant pathogenic fungi and is an extremely potent suppressive agent for various immunological systems.
Laatsch
H
H
Department of Organic Chemistry, University of Göttingen, Germany.
Kellner
M
M
Wolf
G
G
Lee
Y S
YS
Hansske
F
F
Konetschny-Rapp
S
S
Pessara
U
U
Scheuer
W
W
Stockinger
H
H
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005285:Fermentation; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009840:Oligomycins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D009840:Oligomycins; C031004:oligomycin A; C084036:oligomycin F