title: Contrast sensitivity dysfunction in Alzheimer's disease.
abstract: We compared the spatial contrast sensitivity of six patients with mild to moderate Alzheimer's disease (AD) and six age-matched control subjects in a parametric design. Results demonstrate reduced contrast sensitivity in patients with AD at all but the lowest frequency tested. The results suggest that the effect of AD on spatial contrast sensitivity is stronger at higher frequencies and provide a rationale for complaints of poor vision in AD patients.
authors.affiliation: Neurology Research Center, St. Mary of the Plains Hospital, Lubbock, TX 79410.
authors.forename: J T
authors.initials: JT
authors.lastname: Hutton
authors.forename: J L
authors.initials: JL
authors.lastname: Morris
authors.forename: J W
authors.initials: JW
authors.lastname: Elias
authors.forename: J N
authors.initials: JN
authors.lastname: Poston
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D000704:Analysis of Variance; D015350:Contrast Sensitivity / Q000502:physiology*; D006801:Humans