title: Negative correlation with liver cell division of a 38 kilodalton protein whose phosphorylation is enhanced by ras and G-proteins.
abstract: We showed earlier that the phosphorylation of a 38 kDa protein (p38) from rat liver plasma membrane is stimulated by ras or endogenous G-proteins. We have now estimated the level of expression of p38 in liver tissues from embryos at different stages of development, regenerating liver and also in tumor cell lines of hepatic origin. Our results indicate that the expression of p38 is negatively correlated with cell division. It is suggested that the phosphorylation of p38, an event which is regulated by ras proteins and G-proteins, could be involved in signal transduction processes associated with the inhibitory regulation of cell division.
authors.affiliation: Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: A N
authors.initials: AN
authors.lastname: Hegde
authors.forename: C V
authors.initials: CV
authors.lastname: Swamy
authors.forename: B M
authors.initials: BM
authors.lastname: Krishna
authors.forename: M R
authors.initials: MR
authors.lastname: Das
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002455:Cell Division / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D010766:Phosphorylation; D016283:Proto-Oncogene Proteins p21(ras) / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology
chemical_list: D008565:Membrane Proteins; C052912:liver plasma membrane protein p38; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)