Pharmacokinetics and clinical effects in dogs of a sustained-release formulation of theophylline.
Theophylline was administered orally in a sustained-release preparation at a dose rate of 20 mg/kg bodyweight to six beagle dogs. A mean (+/- se) maximum plasma concentration of 12.2 +/- 0.65 micrograms/ml was obtained 5.17 +/- 0.70 hours after administration and it was calculated to have a mean residence time of 9.09 hours. When given at 40 mg/kg bodyweight twice daily for five days the theophylline preparation was well tolerated, but, the dogs developed a marked tachycardia and hyperpnoea which were attributed to the high plasma concentrations (> 30 micrograms/ml) reached during this dosage regimen.
McKellar
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QA
Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden.
D000284:Administration, Oral; D000818:Animals; D003692:Delayed-Action Preparations; D004285:Dogs / Q000097:blood* / Q000502:physiology; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D006439:Hemodynamics / Q000187:drug effects; D013806:Theophylline / Q000493:pharmacokinetics* / Q000494:pharmacology
D003692:Delayed-Action Preparations; D013806:Theophylline