Effects on fibrinolytic activity of corn oil and a fish oil preparation enriched with omega-3-polyunsaturated fatty acids in a long-term study.
In addition to their beneficial effects in reducing platelet responsiveness, it has been a matter of controversy whether polyunsaturated fatty acids impair the fibrinolytic system or not. In a double-blind, parallel clinical trial, 40 subjects were randomized to treatment with 6 g/day of corn oil, or to 6 g/day of a fish oil preparation, enriched with omega-3-polyunsaturated fatty acids (2.0 g/day of omega-3-PUFA). Clinical and fibrinolytic variables were measured before and after 5 months of treatment. In the corn oil group, plasminogen activator inhibitor (PAI-1) decreased significantly but in the cod liver oil group, PAI-1 remained unchanged. Activities and mass concentrations of tissue plasminogen activator (t-PA) were unchanged in both groups. It is concluded that, in the doses given here, both these preparations have small or no effects on the fibrinolytic system.
Hellsten
G
G
Primary Health Care Centre, Norsjö, Sweden.
Boman
K
K
Saarem
K
K
Hallmans
G
G
Nilsson
T K
TK
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003060:Cod Liver Oil / Q000494:pharmacology*; D003314:Corn Oil / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications / Q000178:diet therapy* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3; D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides; D003314:Corn Oil; D003060:Cod Liver Oil; D002784:Cholesterol; D010959:Tissue Plasminogen Activator