title: Comparison of the acid-base status of blood obtained from intraosseous and central venous sites during steady- and low-flow states.
abstract: OBJECTIVE
  To compare the acid-base status of blood obtained from the tibial intraosseous site with that status obtained from a central venous site during stead- and low-flow states in a piglet model.
  
  
  METHODS
  A prospective, observational study.
  
  
  METHODS
  Animal laboratory at a university medical center.
  
  
  METHODS
  Nine 2-day-old piglets.
  
  
  METHODS
  Animals were anesthetized, intubated, and mechanically ventilated. A thermodilution pulmonary artery catheter was inserted via the right internal jugular vein and directed into the pulmonary artery. An arterial catheter was inserted into the right carotid artery and an intraosseous needle was inserted into the proximal tibial marrow cavity. Cardiorespiratory arrest was induced by discontinuation of ventilation. The animals were subsequently resuscitated by precordial compressions and ventilation. Blood samples were obtained from central venous and intraosseous sites during steady state and during resuscitation (low-flow state).
  
  
  RESULTS
  No significant differences (p < .05) were found for pH, PCO2, and bicarbonate concentration when values that were obtained from the central venous and intraosseous sites were compared during steady- and low-flow states.
  
  
  CONCLUSIONS
  The acid-base status of intraosseous blood is similar to that status of central venous blood. Intraosseous blood gas values may be an acceptable alternative to central venous blood gas values in judging central acid-base status during cardiopulmonary resuscitation.
authors.affiliation: Department of Pediatrics, University of Florida, Jacksonville.
authors.forename: N
authors.initials: N
authors.lastname: Kissoon
authors.forename: H
authors.initials: H
authors.lastname: Rosenberg
authors.forename: J
authors.initials: J
authors.lastname: Gloor
authors.forename: R
authors.initials: R
authors.lastname: Vidal
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D001784:Blood Gas Analysis; D016887:Cardiopulmonary Resuscitation; D002405:Catheterization, Central Venous; D002406:Catheterization, Peripheral; D006323:Heart Arrest / Q000097:blood* / Q000628:therapy; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000097:blood* / Q000628:therapy; D012131:Respiratory Insufficiency / Q000097:blood* / Q000628:therapy; D013552:Swine; D013815:Thermodilution; D013977:Tibia; D014680:Veins