title: Decreased fibrinolytic potential in patients with idiopathic avascular necrosis and transient osteoporosis of the hip.
abstract: A thrombotic etiology has been suggested as the cause of idiopathic avascular necrosis of the hip, although the underlying pathophysiological mechanisms are unknown. Transient osteoporosis of the hip has also been suggested to represent bone marrow edema that may be related to ischemia. We evaluated four patients with idiopathic avascular necrosis and one patient with transient osteoporosis of the hip for thrombotic potential placing a special emphasis on the fibrinolytic system. All five patients had identifiable abnormalities of fibrinolysis. Four patients had elevated levels of plasminogen activator inhibitor (PAI-1) and one patient had an inadequate increase in tissue plasminogen activator (tPA) post venous occlusion. Serum triglycerides were increased in three of the patients. These findings suggest an association between decreased fibrinolytic potential and the subsequent development of avascular necrosis and transient osteoporosis of the hip. These patients should have an evaluation of the fibrinolytic system with tPA and PAI-1 levels as well as a lipid profile.
authors.affiliation: Department of Medicine, University of Kansas Medical Center, Kansas City.
authors.forename: P J
authors.initials: PJ
authors.lastname: Van Veldhuizen
authors.forename: J
authors.initials: J
authors.lastname: Neff
authors.forename: M D
authors.initials: MD
authors.lastname: Murphey
authors.forename: D
authors.initials: D
authors.lastname: Bodensteiner
authors.forename: B S
authors.initials: BS
authors.lastname: Skikne
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005342:Fibrinolysis; D006621:Hip Joint / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D010020:Osteonecrosis / Q000097:blood* / Q000000981:diagnostic imaging; D010024:Osteoporosis / Q000097:blood* / Q000000981:diagnostic imaging; D010314:Partial Thromboplastin Time; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010976:Platelet Count; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D011859:Radiography; D010959:Tissue Plasminogen Activator / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; D017293:Protein S; D014280:Triglycerides; D000990:Antithrombin III; D002784:Cholesterol; D010959:Tissue Plasminogen Activator