Important role of C-terminal peptide bonds for endothelin receptor binding and activity.
Olsen
U B
UB
Department of Pharmacology, Novo Nordisk CNS-R&D, Måløv, Denmark.
Weis
J U
JU
Suzdak
P
P
Lundt
B F
BF
Madsen
K
K
Thøgersen
H
H
Johansen
N L
NL
D000818:Animals; D001013:Aorta, Thoracic; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000494:pharmacology / Q000502:physiology*; D005748:Gastric Fundus / Q000187:drug effects; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000502:physiology; D010455:Peptides; D011817:Rabbits; D051381:Rats; D017466:Receptors, Endothelin / Q000378:metabolism*; D013329:Structure-Activity Relationship
D016232:Endothelins; D010455:Peptides; D017466:Receptors, Endothelin