title: [Atrial natriuretic factor as a marker of clinical severity in cardiac failure].
abstract: The authors examined plasma levels of the atrial natriuretic factor (ANF) in 26 patients with manifestations of cardiac failure. The ANF levels were high as compared with reference values (21 +/- 16.7 fmol/ml vs. 4.9 +/- 2.1 fmol/ml) and different in relation to individual functional NYHA classes, i.e. the lowest ones were in the second and the highest ones in the fourth class. Concurrently the authors revealed a statistically significant negative exponential correlation between plasma ANF levels and the left ventricular ejection fraction (r = 0.550, p < 0.01) and a bordeline correlation between ANF and the stroke volume (r = -0.45, p = 0.05). The results indicate that the plasma ANF level is a good indicator of severity of cardiac weakness and can be used in clinical work as a prognostic indicator in patients with heart failure.
authors.affiliation: II. interná klinika FN Kosice.
authors.forename: I
authors.initials: I
authors.lastname: Suchmanová-Lazúrová
authors.forename: R
authors.initials: R
authors.lastname: Rybár
authors.forename: I
authors.initials: I
authors.lastname: Majercák
authors.forename: G
authors.initials: G
authors.lastname: Valocík
authors.forename: E
authors.initials: E
authors.lastname: Fedorová
authors.forename: Y
authors.initials: Y
authors.lastname: Machánová
authors.forename: R
authors.initials: R
authors.lastname: Tkácová
authors.forename: D
authors.initials: D
authors.lastname: Trejbal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor
vernacular_title: Predsienový nátriuretický faktor ako marker klinickej závaznosti srdcového zlyhania.