Dantrolene protects against ischemic, delayed neuronal death in gerbil brain.
The effect was examined of dantrolene, a drug for malignant hyperthermia acting through preventing release of Ca from the ryanodine-type intracellular stores in muscle cells, on ischemic delayed neuronal death in field CA1 of gerbil hippocampus. Dantrolene (1.6 mM in concentration, 3 microliters each in volume), when administered bilaterally in the lateral ventricles 30 min after reperfusion after transient forebrain ischemia for 3 min at 37 degrees C, significantly protected against the neuronal death. It is proposed that the dantrolene-sensitive (most likely, the ryanodine-type) intracellular Ca stores in CA1 pyramidal cells play a pivotal role in the development of ischemic neuronal damage.
Zhang
L
L
Department of Physiology, Ehime University School of Medicine, Japan.
Andou
Y
Y
Masuda
S
S
Mitani
A
A
Kataoka
K
K
D000818:Animals; D001921:Brain / Q000473:pathology*; D002339:Carotid Arteries / Q000502:physiology; D016923:Cell Death / Q000187:drug effects; D003620:Dantrolene / Q000008:administration & dosage / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D007276:Injections, Intraventricular; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D017966:Pyramidal Cells / Q000187:drug effects; D012433:Ryanodine / Q000494:pharmacology
D012433:Ryanodine; D003620:Dantrolene