title: Adaptation of Escherichia coli to the uncoupler of oxidative phosphorylation 2,4-dinitrophenol.
abstract: Escherichia coli was found to adapt to the uncoupler of oxidative phosphorylation 2,4-dinitrophenol. The rates of synthesis of 53 proteins were increased following exposure to 2,4-dinitrophenol. Adaptation was accelerated when the cofactor pyrroloquinoline quinone was provided in the growth medium.
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620.
authors.forename: D J
authors.initials: DJ
authors.lastname: Gage
authors.forename: F C
authors.initials: FC
authors.lastname: Neidhardt
mesh_terms: D019297:2,4-Dinitrophenol; D000064:Acclimatization; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D003067:Coenzymes / Q000494:pharmacology; D004140:Dinitrophenols / Q000633:toxicity*; D004798:Enzymes / Q000096:biosynthesis; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005798:Genes, Bacterial; D007700:Kinetics; D008715:Methionine / Q000378:metabolism; D045542:PQQ Cofactor; D015363:Quinolones / Q000494:pharmacology*; D013462:Sulfur Radioisotopes; D014475:Uncoupling Agents / Q000633:toxicity*
chemical_list: D001426:Bacterial Proteins; D003067:Coenzymes; D004140:Dinitrophenols; D004798:Enzymes; D015363:Quinolones; D013462:Sulfur Radioisotopes; D014475:Uncoupling Agents; D045542:PQQ Cofactor; D008715:Methionine; D019297:2,4-Dinitrophenol