An association of pulmonary hypoplasia with unilateral agenesis of the diaphragm.
During a period of 5 years, 33 newborns with congenital diaphragmatic hernia were treated. Three groups presenting with respiratory distress in the delivery room were identified. These included 8 newborns with agenesis (group 1) and 4 newborns with nonagenesis (group 2), all of whom died. There were 19 nonagenesis survivors (group 3), giving an overall survival rate of 61%. Two newborns who presented beyond 6 hours of life were excluded. No one specific arterial blood gas value or ventilation parameter obtained preoperatively could predict survival. Postmortem right and left lung weights, lung/body weight ratio, and radial alveolar counts demonstrate that agenesis is a unique subgroup with profound pulmonary hypoplasia and a dismal prognosis.
Muraskas
J K
JK
Division of Neonatology, Loyola University Medical Center, Maywood, IL 60153.
Husain
A
A
Myers
T F
TF
Anderson
C L
CL
Black
P R
PR
D003964:Diaphragm / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery; D005260:Female; D005865:Gestational Age; D006548:Hernia, Diaphragmatic / Q000473:pathology / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities* / Q000473:pathology; D008297:Male; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000473:pathology; D011296:Prenatal Diagnosis; D019736:Prostheses and Implants; D011650:Pulmonary Alveoli / Q000473:pathology
D011138:Polytetrafluoroethylene