title: On the causes of multiple sclerosis.
abstract: Evidence on aetiology in multiple sclerosis suggests that the prevalence depends on the interaction of two factors, diet and exposure to visible sunlight. The dietary features which may be beneficial include supplementation with fish oils, avoidance of saturated fats, and the associated intake of antioxidants with unsaturated fatty acids. Inhibition, by antioxidants, of the enzyme lipoxygenase inhibits leukotriene synthesis, and the presence of fish oils leads to the production of leukotrienes with less inflammatory properties. This is of particular importance in the retina where leukotrienes might be the underlying cause of retrobulbar neuritis. The antioxidant properties of vitamin A may also lead to inhibition of leukotriene synthesis. Visible solar radiation could be of benefit therefore by releasing vitamin A from visual pigment rhodopsin. The interaction of these two factors may explain the epidemiological observations on the prevalence of multiple sclerosis.
authors.affiliation: City Hospital, Nottingham, UK.
authors.forename: C
authors.initials: C
authors.lastname: Hutter
mesh_terms: D004032:Diet; D004041:Dietary Fats; D005395:Fish Oils; D006801:Humans; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000209:etiology*; D015995:Prevalence; D013472:Sunlight; D014801:Vitamin A
chemical_list: D004041:Dietary Fats; D005395:Fish Oils; D014801:Vitamin A