Amniotic fluid acetylcholinesterase is found in gastroschisis but not omphalocele.
Amniotic fluid acetylcholinesterase (ACHE) has been used to evaluate neutral tube defects. It has also been detected in ventral wall defects. However, the role of ACHE to differentiate between omphalocele and gastroschisis has not been established. We examined amniotic fluid ACHE in 16 pregnancies complicated by gastroschisis and 8 by omphalocele. One ruptured omphalocele was excluded. ACHE was negative in all 7 omphaloceles and either positive or suspicious in all gastroschises (chi 2 = 17.3, p < 0.0001). Amniotic fluid ACHE may be useful to differentiate between omphalocele and gastroschisis.
Saleh
A A
AA
Department of Obstetrics and Gynecology, Molecular Biology and Genetics, Hutzel Hospital, Wayne State University, Detroit, Mich.
Isada
N B
NB
Johnson
M P
MP
Sokol
R J
RJ
Dombrowski
M P
MP
Evans
M I
MI
D000009:Abdominal Muscles / Q000002:abnormalities*; D000110:Acetylcholinesterase / Q000032:analysis*; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000201:enzymology*; D016009:Chi-Square Distribution; D003937:Diagnosis, Differential; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000201:enzymology; D006554:Hernia, Umbilical / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D011247:Pregnancy
D000110:Acetylcholinesterase