[Effect of quinolones on mice experimental infection by Plasmodium berghei and their possible therapeutic usefulness].
The search for new antimalarial drugs is important for many reasons, specially because of the resistance of plasmodia. Some clinical and laboratory studies have recently indicated that quinolones, currently in use for treatment of bacterial infections, have antimalarial activity. So, we evaluated the possible action of ciprofloxacin, norfloxacin, ofloxacin and pefloxacin in mice experimentally infected by Plasmodium berghei, by the oral route. Taking into account parasitemia and mortality, we came to conclusion that these drugs are not effective, as judged by the methods used.
Amato Neto
V
V
Laboratório de Investigação Médica (Parasitologia), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo.
Braz
L M
LM
Campos
R
R
Matsubara
L
L
Silva
M de F
Mde F
Pinto
P L
PL
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D005260:Female; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D008807:Mice, Inbred BALB C; D009643:Norfloxacin / Q000627:therapeutic use; D015242:Ofloxacin / Q000627:therapeutic use; D015366:Pefloxacin / Q000627:therapeutic use; D010962:Plasmodium berghei
D000890:Anti-Infective Agents; D015366:Pefloxacin; D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin
Observações sobre o efeito de quinolonas na infecção experimental de camundongos pelo Plasmodium berghei e sobre sua eventual utilidade terapêutica.