Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. II. Structure elucidation.
The structures of novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were elucidated as shown in Fig. 1 by NMR spectral analysis including a variety of two-dimensional techniques. The quinolidomicins possess a novel 60-membered macrolide ring, which is to our knowledge the largest among natural products.
Hayakawa
Y
Y
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Shin-ya
K
K
Furihata
K
K
Seto
H
H
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008847:Micromonospora / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides; C084379:quinolidomicin A2; C084380:quinolidomicin B1; C084378:quinolidomicin A1