title: The role of the immune system in establishment of herpes simplex virus latency--studies using CD4+ T-cell depleted mice.
abstract: The immunological mechanisms involved in establishment of herpes simplex virus (HSV) latency were studied in normal and CD4+ T-cell depleted C57BL/6J mice following intravaginal infection. During transition from acute to latent ganglionic infection two consecutive processes were observed: first, clearance of infectious virus from the ganglia, and second, reduction of the number of infected ganglia.
authors.affiliation: Institute of Medical Microbiology and Immunology, University of Bonn, Federal Republic of Germany.
authors.forename: D S
authors.initials: DS
authors.lastname: Schmidt
authors.forename: A M
authors.initials: AM
authors.lastname: Eis-Hübinger
authors.forename: K E
authors.initials: KE
authors.lastname: Schneweis
mesh_terms: D000818:Animals; D005260:Female; D005724:Ganglia / Q000382:microbiology; D006561:Herpes Simplex / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018139:Simplexvirus / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D017735:Virus Latency / Q000276:immunology*