[Comparison of topical therapeutic effect between silver norfloxacin (Ag-NFL) and silver sulfadiazine (Ag-SD) in treatment of pyocyaneous sepsis in burn rats].
The purpose of the study was to carry out a further investigation of the efficacy of topical antimicrobial treatment of Ag-NFL in comparison with that of the most commonly used topical agent Ag-SD. An experimental model of rats with 20% TBSA full thickness burns seeded with 109 CFU of Pseudomonas aeruginosa ATCC-27853 was used. At 24, 48 and 72h after the seeding bacteriologic examination showed that the subeschar bacterial counts exceeded 10(6) CFU per gram of tissue. Subeschar bacterial counts were zero in the group in which Ag-NFL was used, while those in the group using Ag-SD were almost the same as the control. The amount of silver accumulated in the eschar of Ag-NFL, treated rats was significantly higher than that of Ag-SD treated rats. In conclusion, Ag-NFL was proved valuable in the treatment of burn wound infection caused by invading organisms, particularly by the Ag-SD resistant strain of Pseudomonas.
Huo
Z L
ZL
Burn Institute, Changhai Hospital.
D000287:Administration, Topical; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy*; D005260:Female; D024841:Fluoroquinolones; D008297:Male; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D014946:Wound Infection / Q000188:drug therapy*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C045339:silver norfloxacin; D009643:Norfloxacin; D012837:Silver Sulfadiazine