title: Epstein-Barr virus and primary lung lymphoma: a study utilizing the polymerase chain reaction.
abstract: Seven cases of primary lung lymphoma were analyzed for the presence of Epstein-Barr virus DNA sequences by the polymerase chain reaction. The series included: four cases of diffuse, small lymphocytic lymphoma; one case of diffuse, intermediate lymphocytic lymphoma; one case of diffuse, small cleaved cell lymphoma; and one case of large cell, immunoblastic lymphoma. The latter occurred in a patient with acquired immunodeficiency syndrome. A 200-bp sequence of the Epstein-Barr nuclear antigen 1 gene was used as a template for PCR amplification. The only tumor that contained Epstein-Barr virus sequences was the immunoblastic lymphoma. These findings support previous observations that small lymphocytic lymphomas of the lung are not related to Epstein-Barr virus infection. In contrast, some large cell lymphomas may represent Epstein-Barr-virus--associated lymphoproliferative disorders.
authors.affiliation: Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029.
authors.forename: P
authors.initials: P
authors.lastname: Hytiroglou
authors.forename: J A
authors.initials: JA
authors.lastname: Strauchen
authors.forename: E
authors.initials: E
authors.lastname: Vrettou
authors.forename: C S
authors.initials: CS
authors.lastname: Papadimitriou
authors.forename: T M
authors.initials: TM
authors.lastname: Fasy
authors.forename: S
authors.initials: S
authors.lastname: Morgello
mesh_terms: D000328:Adult; D000368:Aged; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D016130:Immunophenotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D008223:Lymphoma / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral; D015335:Molecular Probes