title: Plasmodium falciparum proteinases and red blood cell invasion.
abstract: Malarial proteinases of the erythrocytic life-cycle are used to design new inhibitors capable of blocking the parasite's development. The Merozoite Proteinase for Erythrocytic Invasion (MPEI) of Plasmodium falciparum, a neutral proteinase, and the acidic Pf37 proteinase acting on spectrin as substrate, are good candidates for this kind of strategy.
authors.affiliation: Laboratoire de Biologie Parasitaire et Chimiothérapie, URA CNRS 114, Muséum National d'Histoire Naturelle, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Schrével
authors.forename: C
authors.initials: C
authors.lastname: Barrault
authors.forename: A
authors.initials: A
authors.lastname: Deguercy
authors.forename: P
authors.initials: P
authors.lastname: Grellier
authors.forename: P
authors.initials: P
authors.lastname: Lawton
authors.forename: H G
authors.initials: HG
authors.lastname: Heidrich
authors.forename: M
authors.initials: M
authors.lastname: Caballero
authors.forename: M
authors.initials: M
authors.lastname: Monsigny
authors.forename: R
authors.initials: R
authors.lastname: Mayer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000469:parasitology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism; D010963:Plasmodium falciparum / Q000201:enzymology* / Q000502:physiology; D015800:Protozoan Proteins / Q000378:metabolism*; D013049:Spectrin / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D015800:Protozoan Proteins; D013049:Spectrin; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C073894:neutral proteinase Pf105, Plasmodium falciparum; C084242:acidic proteinase Pf37, Plasmodium falciparum