Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9.
Ciliary neurotrophic factor (CNTF) has recently been found to be important for the survival of motor neurons and has shown activity in animal models of amyotrophic lateral sclerosis (ALS). CNTF therefore holds promise as a treatment for ALS, and it and its receptor (CNTFR) are candidates for a gene involved in familial ALS. The CNTFR gene was mapped to chromosome 9 by PCR on a panel of human/CHO somatic cell hybrids and localized to 9p13 by PCR on a panel of radiation hybrids.
Donaldson
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Eleanor Roosevelt Institute, Denver, Colorado 80206.
Britt
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Jones
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Jackson
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Patterson
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D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D016466:CHO Cells; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D020801:Receptor, Ciliary Neurotrophic Factor; D017978:Receptors, Growth Factor / Q000235:genetics*
D020801:Receptor, Ciliary Neurotrophic Factor; D017978:Receptors, Growth Factor; D004247:DNA