Further substantiation of a significant role for the sympathetic nervous system in inflammation.
This study provides significant new evidence substantiating a role of the postganglionic sympathetic neuron in plasma extravasation in the knee-joint of the rat. Increased plasma extravasation produced by the potent inflammatory mediator bradykinin was mimicked by 6-hydroxydopamine, a selective stimulator of sympathetic fibers. Various treatments (chemical sympathectomy, co-perfusion with the local anesthetic lidocaine, or co-perfusion with depolarizing concentrations of potassium) similarly modulated plasma extravasation induced by both bradykinin and 6-hydroxydopamine, but not that produced by platelet activating factor. We also showed that bradykinin is able to release norepinephrine in the knee-joint, indicating action on the sympathetic postganglionic neuron. In summary, these experiments provide substantial additional evidence supporting a significant contribution of the sympathetic post-ganglionic neuron terminal to inflammatory plasma extravasation.
Green
P G
PG
Department of Medicine, University of California, San Francisco 94143.
Luo
J
J
Heller
P H
PH
Levine
J D
JD
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D001920:Bradykinin / Q000633:toxicity; D005122:Exudates and Transudates; D007249:Inflammation / Q000503:physiopathology*; D007719:Knee Joint; D008012:Lidocaine / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine / Q000633:toxicity; D010972:Platelet Activating Factor / Q000633:toxicity; D011188:Potassium / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013563:Sympathectomy, Chemical; D017779:Sympathetic Fibers, Postganglionic / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D010972:Platelet Activating Factor; D016627:Oxidopamine; D008012:Lidocaine; D011188:Potassium; D001920:Bradykinin; D009638:Norepinephrine