title: Recurrent rectal cancer: diagnosis with dynamic MR imaging.
abstract: OBJECTIVE
  To evaluate whether dynamic magnetic resonance (MR) imaging can increase the diagnostic accuracy in suspected local recurrence of rectal carcinoma.
  
  
  METHODS
  Eighteen patients (seven men, 11 women, aged 26-78 years) with 19 suspect lesions were examined. T1-weighted (pre- and postcontrast) and T2-weighted spin-echo images were read by three observers. Computed tissue-specific enhancement parameters were obtained and displayed on gray-scale images (pharmacokinetic mapping).
  
  
  RESULTS
  Reading of the spin-echo images yielded a sensitivity of 91%-100% (confidence interval, 67%, 100%), a specificity of 29%-43% (12%, 67%), and an accuracy of 71%-75% (48%, 91%). Analysis of the MR data showed greater (P = .0038) and faster (P = .0018) enhancement of malignant lesions (n = 12) compared with benign lesions (n = 7).
  
  
  CONCLUSIONS
  Pharmacokinetic mapping of dynamic MR imaging data allows in vivo insight into tissue physiopathology, helping differentiate benign from malignant pelvic lesions in rectal cancer.
authors.affiliation: Research Program Radiological Diagnostics and Therapy, German Cancer Research Center, Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Müller-Schimpfle
authors.forename: G
authors.initials: G
authors.lastname: Brix
authors.forename: G
authors.initials: G
authors.lastname: Layer
authors.forename: P
authors.initials: P
authors.lastname: Schlag
authors.forename: R
authors.initials: R
authors.lastname: Engenhart
authors.forename: S
authors.initials: S
authors.lastname: Frohmuller
authors.forename: T
authors.initials: T
authors.lastname: Hess
authors.forename: I
authors.initials: I
authors.lastname: Zuna
authors.forename: W
authors.initials: W
authors.lastname: Semmler
authors.forename: G
authors.initials: G
authors.lastname: van Kaick
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D003937:Diagnosis, Differential; D004338:Drug Combinations; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000453:epidemiology; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011237:Predictive Value of Tests; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA