Effect of some potassium selective crown ethers on the permeability and structure of a phospholipid membrane.
The effect of some new crown ethers on the cation efflux and phase transition parameters of dipalmitoyl phosphatidylcholine liposomes was studied. The effects were correlated with the lipophilicity of the crown ethers. The results indicate that the presence of two crown ring structures in one crown either molecule is a prerequisite for the increase of ion permeability of liposomes. The effective crown ethers decrease the temperature, enthalpy and cooperativity of the gel-to-liquid crystalline phase transition. The crown ethers increase membrane permeability for potassium and, to a lesser extent, for rubidium and sodium. The ratio of permeability increase for potassium/rubidium significantly correlates with the lipophilicity of the crown ethers.
Szögyi
M
M
Institute of Biophysics, Semmelweis Medical University, Budapest, Hungary.
Cserháti
T
T
Tölgyesi
F
F
D004988:Ethers, Cyclic / Q000737:chemistry / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008081:Liposomes / Q000737:chemistry*; D008962:Models, Theoretical; D010539:Permeability; D010743:Phospholipids / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
D004988:Ethers, Cyclic; D008081:Liposomes; D010743:Phospholipids; D011188:Potassium