[Fatal fulminant hepatitis induced by nilutamide (Anandron)].
The first case of fatal fulminant hepatitis probably caused by nilutamide, a non steroidal antiandrogen derivative, is reported. Nilutamide administration had been continued for 6 days after the occurrence of jaundice, 52 days after beginning of treatment. The rapidly fatal outcome might have been promoted by coadministration of phenobarbital.
Pescatore
P
P
Service d'Hépatologie, Hôpital Beaujon, Clichy.
Hammel
P
P
Durand
F
F
Bertheau
P
P
Bernuau
J
J
Huc
D
D
Gerbal
J L
JL
Degott
C
C
Benhamou
J P
JP
D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D004347:Drug Interactions; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D048289:Imidazolidines; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000188:drug therapy
D000726:Androgen Antagonists; D007093:Imidazoles; D048289:Imidazolidines; C021277:nilutamide; D010634:Phenobarbital
Hépatite fulminante mortelle imputable au nilutamide (Anandron).