title: Antenatal detection of congenital diaphragmatic hernias: the northern region experience.
abstract: This study analyses 7 years of data relating to congenital diaphragmatic herniation in the Northern Region. Ninety-nine confirmed cases were notified to the Northern Region Fetal Abnormality Survey between 1985 and 1991, which is an incidence of 0.35 per 1000 births. A specific diagnosis of CDH was made by antenatal ultrasound in 21 fetuses. The rate of detection improved from 6% to 41% but this had no impact on survival; severe pulmonary hypoplasia was found in the majority dying in the first 48 h. Another structural abnormality occurred in 29% and was the primary antenatal scan diagnosis in 11 fetuses. No other reliable indicator of outcome was identified, including the gestation when detected. The incidence of chromosomal abnormality was 5% and Fryns' syndrome 4%.
authors.affiliation: Northern Region Fetal Abnormality Survey Steering Group, Newcastle upon Tyne.
authors.forename: E
authors.initials: E
authors.lastname: Dillon
authors.forename: M
authors.initials: M
authors.lastname: Renwick
mesh_terms: D005260:Female; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000000981:diagnostic imaging*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging; D008168:Lung / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D016216:Ultrasonography, Prenatal