Osteoporosis and bone metabolic parameters in dependence upon calcium intake through milk and milk products.
The bone mineral content of young adults as well as of osteoporotic patients and age-matched controls without bone disease was measured by single-photon absorptiometry. A retrospective nutrition survey was additionally made to study the relationship between bone mineral content and calcium intake in different periods of life. The bone mineral content and bone mineral density of young adults is directly related to the calcium intake through milk and dairy products. The osteoporotics had a significantly lower bone mineral content than the controls. Calcium intake through milk and milk products in childhood and adolescence had been significantly lower in the patients than in the controls, whereas in the later periods of life (20-30 years prior to the study and at the time of the study) there were no significant differences between the calcium intakes of the two groups. It was also found that an adequate intake of calcium protected against increased bone resorption, as evidenced in particular by the reduced levels of serum osteocalcin, a parameter of bone turnover. In conclusion it can be stated that the data support the hypothesis that adequate calcium intake through milk and milk products in childhood and adolescence is a decisive marker for obtaining a maximum bone mass (peak adult bone mass) and for the prevention of osteoporosis. Furthermore, it can be stated that increased calcium intake in the later years may not reduce the accelerated risk of osteoporosis resulting from inadequate calcium intake during childhood and adolescence.
Stracke
H
H
III. Medical Department, University of Giessen, Germany.
Renner
E
E
Knie
G
G
Leidig
G
G
Minne
H
H
Federlin
K
K
D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D015519:Bone Density; D001862:Bone Resorption; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002648:Child; D003611:Dairy Products; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D008892:Milk; D009749:Nutrition Surveys; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000378:metabolism*; D011379:Prognosis; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012307:Risk Factors
D002136:Calcium, Dietary; D015675:Osteocalcin