Segmentation of the Drosophila embryo.
Segmentation in Drosophila is a sequential process directed by at least 30 genes that encode various types of proteins, including: many transcription factors; a putative RNA-binding protein; a membrane-associated receptor kinase; several intracellular protein kinases; a number of secreted signaling molecules; and others of unknown function. Although the detailed molecular reactions used to generate the metameric subdivisions of the embryo are not yet understood, a general outline of the processes involved has been described. The manner in which spatial relations in the developing embryo are established can now be described.
Kornberg
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Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
Tabata
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D000818:Animals; D016764:Cell Polarity; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000378:metabolism