Detection and characterization of mupirocin resistance in Staphylococcus aureus.
Fourteen mupirocin-resistant Staphylococcus aureus strains were isolated over 18 months; 12 exhibited low-level resistance, while two showed high-level resistance. Highly mupirocin-resistant strains contained a large plasmid which transferred mupirocin resistance to other S. aureus strains and to Staphylococcus epidermidis. This plasmid and pAM899-1, a self-transferable gentamicin resistance plasmid, have molecular and biologic similarities.
Janssen
D A
DA
Division of Infectious Diseases, Department of Veterans Affairs Medical Center, University of Michigan Medical School, Ann Arbor 48105.
Zarins
L T
LT
Schaberg
D R
DR
Bradley
S F
SF
Terpenning
M S
MS
Kauffman
C A
CA
D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000302:isolation & purification; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology*; D010641:Phenotype; D010957:Plasmids; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000235:genetics
D004269:DNA, Bacterial; D016712:Mupirocin