Brain angiotensin AT-2 receptor antagonism and water intake.
Intracerebroventricular administration of the angiotensin AT-2 receptor antagonist, PD 123319, inhibited drinking induced in rats by hypertonic NaCl, carbachol, isoproterenol, hypovolemia, and water deprivation, but had no effect on food intake. In contrast, the AT-1 antagonist, losartan potassium, had no effect on these intakes. A model of thirst is presented that incorporates an AT-2 receptor in a final common pathway for drinking.
Rowland
N E
NE
Department of Psychology, University of Florida, Gainesville 32611-2065.
Fregly
M J
MJ
D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004327:Drinking Behavior / Q000187:drug effects*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology; D019808:Losartan; D008297:Male; D008959:Models, Neurological; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013777:Tetrazoles / Q000008:administration & dosage / Q000494:pharmacology*
D057911:Angiotensin Receptor Antagonists; D001713:Biphenyl Compounds; D007093:Imidazoles; D011725:Pyridines; D013777:Tetrazoles; C073402:PD 123319; D002217:Carbachol; D019808:Losartan; D007545:Isoproterenol