Postradiation volume changes in gamma unit-treated cerebral arteriovenous malformations.
Postradiation changes in angiographically determined nidus volume were quantitatively studied in 22 arteriovenous malformation (AVM) cases treated by gamma unit radiosurgery. The postradiosurgical decrease was statistically significant by post-treatment year 2 (p < .05). In children, AVMs tended to be obliterated more quickly than in adults. Volume reduction was more rapid in nidi receiving 25 Gy or more than in those receiving less than 25 Gy (p < .01). However, there were no significant differences in nidus volume decrease between these two dose groups at the second or third postradiosurgical year. Dose response curves were obtained 1, 2, and 3 years following treatment.
Yamamoto
M
M
Department of Neurosurgery, Tokyo Women's Medical College Dai-ni Hospital, Japan.
Jimbo
M
M
Ide
M
M
Lindquist
C
C
Steiner
L
L
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D002648:Child; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000295:instrumentation; D012737:Sex Factors; D016896:Treatment Outcome