title: Chemoradiation therapy: effect on dental development.
abstract: Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care. Defects noted include tooth and root agenesis, root thinning and shortening, and localized enamel defects. Histologically, these defects appear as osteoid-like niches in the developing dentin which alter the overlying enamel. Odontogenic cell sensitivity is dependent upon the position on the cell cycle and the mitotic activity at the time of chemoradiation therapy. Knowledge of the stage of dental development at the time of oncology treatment and the type of therapy allows the clinician to predict dental effects of the chemoradiation. Representative cases illustrate the clinical manifestations of chemoradiation on the developing dentition.
authors.affiliation: Pediatric Dentistry, U.S. Army Dental Activity, Würzburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Goho
mesh_terms: D000565:Ameloblasts / Q000187:drug effects / Q000528:radiation effects; D000566:Amelogenesis / Q000187:drug effects / Q000528:radiation effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000009:adverse effects; D016371:Cranial Irradiation / Q000009:adverse effects*; D003810:Dentinogenesis / Q000187:drug effects / Q000528:radiation effects; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000188:drug therapy / Q000532:radiotherapy; D009804:Odontoblasts / Q000187:drug effects / Q000528:radiation effects; D009805:Odontogenesis / Q000187:drug effects* / Q000528:radiation effects*; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents