Pharmacokinetics and relative bioavailability of nimodipine capsules and tablets in 8 Chinese healthy men.
A single oral dose of tablets or capsules of 239 mumol nimodipine was given to 8 healthy volunteers of Han nationality in a randomized crossover study. Plasma levels were determined with HPLC method. The plasma concentration-time curve fitted to a first order absorption, 1-compartment open model, and the T1/2K was around 2 h. Although the capsules could reach peak level faster, the bioavailability was not significantly different from that of the tablets.
Guo
L Q
LQ
Department of Clinical Pharmacology, Jinling Hospital, Nanjing, China.
Tan
H S
HS
Chen
G
G
D000328:Adult; D001682:Biological Availability; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D009553:Nimodipine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets
D002214:Capsules; D013607:Tablets; D009553:Nimodipine