Assignment of the human aggrecan gene AGC1 to 15q25-->q26.2 by in situ hybridization.
The human aggrecan gene (AGC1) has been localized to 15q25-->q26.2 by in situ hybridization. Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan. This raises the possibility that AGC1 and mel-CSPG may be the same gene.
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Abteilung Klinische Genetik, Universität Ulm, Germany.
Klett
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Vetter
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Vogel
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D053674:Aggrecans; D000951:Antigens, Neoplasm / Q000235:genetics*; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics*; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D016326:Extracellular Matrix Proteins; D006801:Humans; D017403:In Situ Hybridization; D037181:Lectins, C-Type; D008545:Melanoma / Q000276:immunology*; D011509:Proteoglycans / Q000235:genetics*
C508319:ACAN protein, human; D053674:Aggrecans; D000951:Antigens, Neoplasm; D011508:Chondroitin Sulfate Proteoglycans; D016326:Extracellular Matrix Proteins; D037181:Lectins, C-Type; D011509:Proteoglycans; C069150:melanoma-associated proteoglycan antigen, human