Effect of Clostridium perfringens epsilon toxin on rat isolated aorta.
The effect of Clostridium perfringens epsilon toxin on rat isolated aorta was investigated. The toxin caused contraction of the isolated aorta in a dose-dependent manner. The toxin induced no contraction of the isolated aorta in low-Na medium and of the tissue stored at 4 C for 7 days. However, tetrodotoxin (TTX) had no effect on the toxin-induced contraction. The toxin-induced contraction was significantly inhibited by phentolamine and prazosin, but did not by atropine, mecamylamine, chlorpheniramine and methysergide. These data suggest that the toxin-caused contraction is mediated through nervous system in rat isolated aorta.
Nagahama
M
M
Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Iida
H
H
Sakurai
J
J
D000818:Animals; D001013:Aorta, Thoracic; D001427:Bacterial Toxins / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003016:Clostridium perfringens; D004305:Dose-Response Relationship, Drug; D007082:Ileum / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000294:innervation; D051381:Rats
D001427:Bacterial Toxins; D002121:Calcium Channel Blockers; C039811:Clostridium perfringens epsilon-toxin; D002118:Calcium