[Action of teicoplanin on coagulase negative staphylococci in hospital units of the hospital Hôtel-Dieu in Paris].
Teicoplanin, a glycopeptide antibiotic, is active against Staphylococci, with the exception of some strains of coagulase negative Staphylococci (SCN). Determination of the in vitro activity of teicoplanin by standard disk methodology is not sufficient, and has to be confirmed by the determination of the minimal inhibitory concentration (MIC) for all strains presenting an inhibition zone diameter below 17 mm. We have studied during four months, the susceptibility of SCN to teicoplanin isolated from different units of the hospital, and in particular from the haematology unit (HU). 186 strains were isolated, 35 p. cent from HU and 65 p. cent from the other units of the hospital. All strains belonged to 11 species: 136 S. epidermidis, 14 S. haemolyticus, 8 S. lugdunensis, 5 S. warneri, 4 S. saprophyticus, 3 S. sciuri, 3 hominis, 2 S. chromogens, 2 xylosus, 2 S. cohnii and 1 S. schleiferi. Twenty five strains out of 186 (13.4%) presented a MIC of 8 or 16 mg/l (MIC verified by the agar dilution method): 7 S. haemolyticus, 16 S. epidermidis, 1 S. warneri et 1 S. capitis. During this study SCN resistant to teicoplanin were never isolated. Twelve out of 25 came from the HU, which correspond to 18 p. cent of the isolated strains in this unit. This result was not significantly different, compared to that of the other units.
Desroys Du Roure
F
F
Laboratoire de Microbiolobie, Hôpital Hôtel-Dieu, Paris, France.
Herrmann
J L
JL
Lagrange
P H
PH
Bouvet
A
A
D004305:Dose-Response Relationship, Drug; D005602:France; D006757:Hospital Units; D006801:Humans; D066298:In Vitro Techniques; D013210:Staphylococcus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D017334:Teicoplanin / Q000494:pharmacology*
D017334:Teicoplanin
Activité de la teicoplanine vis-à-vis des staphylocoques à coagulase négative (SCN) au sein des services hospitaliers de l'Hôtel-Dieu de Paris.