Investigation of the usefulness of the photodynamic reaction for the purging of bone marrow from metastatic neuroblastoma cells.
The neuroblastoma cell lines SK-N-LO, SK-PN-DW and IMR 5 were stained with Merocyanine 540 and exposed to white light. 99% of clonogenic tumour cells were destroyed while 60% of bone marrow progenitor cells survived this treatment.
Köhler
A
A
Children's Hospital Jussuf Ibrahim, University of Jena, Germany.
Müller
A
A
Zintl
F
F
D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D016465:Bone Marrow Purging; D002470:Cell Survival; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008027:Light; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011744:Pyrimidinones / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D017319:Photosensitizing Agents; D011744:Pyrimidinones; C003954:merocyanine dye