A comparative study of labelled neutrophil behaviour in patients with rheumatoid arthritis and normal volunteers.
A comparative study of neutrophil pharmacokinetics and distribution between normal volunteers and patients with rheumatoid arthritis (RA) is presented. White cell viability was confirmed by prominent localization of activity in the spleen with minimal liver uptake and lack of retention in the lungs in both normal volunteers and RA patients. There were no significant differences between both groups in granulocyte clearance from the lungs and their subsequent distribution in the spleen, bone marrow and liver. The results of this study demonstrate that the behaviour of granulocytes in RA patients is essentially unchanged from that of normal volunteers.
al-Janabi
M A
MA
Department of Nuclear Medicine, Royal Liverpool University Hospital, UK.
Jones
A K
AK
Solanki
K
K
Critchley
M
M
Britton
K E
KE
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000473:pathology*; D002470:Cell Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000000981:diagnostic imaging / Q000502:physiology*; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012016:Reference Values; D019690:Technetium Tc 99m Exametazime
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime