Phosphocitrate prevents disease progression in murine progressive ankylosis.
OBJECTIVE
Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression.


METHODS
Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle.


RESULTS
Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice.


CONCLUSIONS
PC appears to inhibit disease progression in murine progressive ankylosis.
Krug
H E
HE
Department of Medicine, Minneapolis Veterans Affairs Medical Center.
Mahowald
M L
ML
Halverson
P B
PB
Sallis
J D
JD
Cheung
H S
HS
D000818:Animals; D000844:Ankylosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D002951:Citrates / Q000627:therapeutic use*; D007592:Joint Diseases / Q000517:prevention & control; D007596:Joints / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains
D002951:Citrates; C014148:phosphocitrate