Hematological effects of the new immunosuppressive drug 15-deoxyspergualin.
Since systematic hematological studies on blood and bone marrow changes after treatment with 15-Deoxyspergualin (DOS) are lacking, a quantitative assessment was performed fourteen or twenty eight days after intraperitoneal application of DOS to rats. Further observations done 7 and 14 days after discontinuation of DOS administration allowed analysis of bone marrow regeneration. DOS induced lymphocytopenia, granulocytopenia and anemia with a decrease of bone marrow cellularity due to suppression of cell maturation. The effect was dose-dependent and bone marrow as well as blood changes were observed in animals treated with doses from 0.5 to 10.0 mg/kg DOS. Within 14 days after termination of the treatment, rapid recovery with normalization of all hematological parameters was observed. In the light of our data, these hematological side effects may not be a major disadvantage, if DOS is used in doses below 2.5 mg/kg, and for a course of therapy which is limited to 7 to 14 days.
Waaga
A M
AM
Department of Immunology, University of Kiel, Germany.
Krzymański
M
M
Ulrichs
K
K
Wierusz-Wysocka
B
B
Müller-Ruchholtz
W
W
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001773:Blood Cells / Q000187:drug effects*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006146:Guanidines / Q000097:blood / Q000494:pharmacology*; D006400:Hematocrit; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000097:blood / Q000494:pharmacology*; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew
D006146:Guanidines; D006454:Hemoglobins; D007166:Immunosuppressive Agents; C037258:gusperimus