The presence of an endogenous murine leukemia virus sequence correlates with the peripheral expansion of gamma delta T cells bearing the BALB invariant delta (BID) T cell receptor delta.
gamma delta T cells participate in immune responses during viral, bacterial, and parasitic infections. However, it is not clear whether they recognize antigens produced by pathogens, or are actually reactive to self-ligands generated during the course of infection. In this paper, we report that the presence of the self-ligand that selectively expands a subset of gamma delta T cells correlates with the presence of an endogenous murine leukemia virus (MuLV) in inbred strains of mice. The implications of this observation for gamma delta T cell specificity and function is discussed.
Sim
G K
GK
Basel Institute for Immunology, Switzerland.
Augustin
A
A
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification; D017931:DNA Primers; D015870:Gene Expression; D009052:Leukemia Virus, Murine / Q000302:isolation & purification*; D051379:Mice; D008812:Mice, Hairless; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008815:Mice, Inbred Strains / Q000276:immunology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D017931:DNA Primers; D016692:Receptors, Antigen, T-Cell, gamma-delta; D004247:DNA