title: Reversal of multidrug resistance to cancer chemotherapy.
abstract: In the past few years, the role of membrane-bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This article reviews the different classes of the current major modulators of multidrug resistance.
authors.affiliation: Department of Oncology, McGill University, Montreal, Quebec, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Leyland-Jones
authors.forename: W
authors.initials: W
authors.lastname: Dalton
authors.forename: G A
authors.initials: GA
authors.lastname: Fisher
authors.forename: B I
authors.initials: BI
authors.lastname: Sikic
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D004351:Drug Resistance / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents