title: Detection and characterization of mupirocin resistance in Staphylococcus aureus.
abstract: Fourteen mupirocin-resistant Staphylococcus aureus strains were isolated over 18 months; 12 exhibited low-level resistance, while two showed high-level resistance. Highly mupirocin-resistant strains contained a large plasmid which transferred mupirocin resistance to other S. aureus strains and to Staphylococcus epidermidis. This plasmid and pAM899-1, a self-transferable gentamicin resistance plasmid, have molecular and biologic similarities.
authors.affiliation: Division of Infectious Diseases, Department of Veterans Affairs Medical Center, University of Michigan Medical School, Ann Arbor 48105.
authors.forename: D A
authors.initials: DA
authors.lastname: Janssen
authors.forename: L T
authors.initials: LT
authors.lastname: Zarins
authors.forename: D R
authors.initials: DR
authors.lastname: Schaberg
authors.forename: S F
authors.initials: SF
authors.lastname: Bradley
authors.forename: M S
authors.initials: MS
authors.lastname: Terpenning
authors.forename: C A
authors.initials: CA
authors.lastname: Kauffman
mesh_terms: D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000302:isolation & purification; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology*; D010641:Phenotype; D010957:Plasmids; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D016712:Mupirocin