title: [Interleukin-6 and glucocorticosteroid responses to cardiopulmonary bypass].
abstract: The responses of interleukin-6 (IL-6), ACTH, cortisol, WBC, CRP to cardiopulmonary bypass (CPB) were studied in 5 patients who underwent elective CABG (N = 4) and AVR (N = 1). IL-6 started to increase from 3 h after the beginning of the operation at which aortic clamp was removed and reached a peak after 4 h at which CPB was withdrawn. ACTH also reached a peak after 4 h. The increase of cortisol started from 2 h when aorta was clamped, which was earlier than that of IL-6. IL-6 and ACTH fell sharply to pre-CPB levels before first postoperative day (1 POD) while cortisol remained high postoperatively. CRP level and WBC counts were maximum at 2 POD. The results suggest that the cortisol response to CPB is not only caused by IL-6, but also by other factors, such as IL-1 and TNF.
authors.affiliation: Department of Anesthesiology, Oita Medical University.
authors.forename: T
authors.initials: T
authors.lastname: Kitano
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Hoashi
authors.forename: S
authors.initials: S
authors.lastname: Yoshitake
authors.forename: K
authors.initials: K
authors.lastname: Setoguchi
authors.forename: H
authors.initials: H
authors.lastname: Iwasaka
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: N
authors.initials: N
authors.lastname: Honda
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000368:Aged; D001021:Aortic Valve / Q000601:surgery; D002097:C-Reactive Protein / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D001026:Coronary Artery Bypass; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative
chemical_list: D015850:Interleukin-6; D000324:Adrenocorticotropic Hormone; D002097:C-Reactive Protein; D006854:Hydrocortisone