title: Lung compliance, lung volume and transfer factor for carbon monoxide in anaesthetised sheep: normal values and reproducibility of measurements.
abstract: Measurements of quasistatic compliance (Cqst), effective alveolar volume (VA,eff) and single-breath transfer factor for carbon monoxide (TL,CO, 'sb') were completed in 16 normal, anaesthetised, adult Texel ewes. Regression equations were computed for these variables as a function of bodyweight and the optimal equations selected. The 95 per cent prediction intervals for the equations were calculated such that normal lung function in similar sheep could be accurately predicted. The long term reproducibility of these measurements was assessed in nine sheep, measured at monthly intervals over a period of five months. Although measurements made in individual sheep were often highly variable, the variation between repeated measurements on the separate days for the group was insignificant.
authors.affiliation: Department of Veterinary Pathology, Royal (Dick) School of Veterinary Studies, Easter Bush, Roslin, Midlothian.
authors.forename: D D
authors.initials: DD
authors.lastname: Collie
authors.forename: N J
authors.initials: NJ
authors.lastname: Watt
authors.forename: P M
authors.initials: PM
authors.lastname: Warren
authors.forename: I
authors.initials: I
authors.lastname: Begara
authors.forename: L
authors.initials: L
authors.lastname: Luján
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism; D005260:Female; D008170:Lung Compliance; D008176:Lung Volume Measurements / Q000662:veterinary*; D011650:Pulmonary Alveoli / Q000502:physiology; D012756:Sheep / Q000502:physiology*
chemical_list: D002248:Carbon Monoxide