Susceptibility of Mycobacterium kansasii to ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid.
The MICs of ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid for clinical isolates of Mycobacterium kansasii were determined by the radiometric (BACTEC) method. All drugs except azithromycin elicited MICs for 90% of the strains tested that were lower than previously reported achievable maximum concentrations in serum. Ofloxacin, sparfloxacin, and clarithromycin had the largest maximum concentration in serum/MIC for 90% of strains ratio of the drugs tested.
Witzig
R S
RS
Department of Infectious Disease, Tulane Medical School, New Orleans, Louisiana 70112.
Franzblau
S G
SG
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005672:Fusidic Acid / Q000494:pharmacology; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D018942:Macrolides; D005672:Fusidic Acid