title: Propofol in rabbits. 1. Determination of an induction dose.
abstract: Propofol was evaluated as an intravenous agent for induction of anesthesia in 94 non-premedicated New Zealand White rabbits (mean body weight 3.25 kg). Lack of chewing oral introduction of an endotracheal tube was chosen as the end-point in signaling loss of consciousness. A rapid and excitement-free loss of consciousness was observed. Using probit analysis, a 50% effective dose of 6.44 mg/kg was calculated. No statistically significant difference between genders was shown. Independent of the dose administered, recovery was rapid and smooth.
authors.affiliation: College of Veterinary Medicine, University of Florida, Gainesville 32610-0144.
authors.forename: G
authors.initials: G
authors.lastname: Aeschbacher
authors.forename: A I
authors.initials: AI
authors.lastname: Webb
mesh_terms: D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D007442:Intubation, Intratracheal / Q000379:methods / Q000662:veterinary; D008297:Male; D015742:Propofol / Q000008:administration & dosage*; D011817:Rabbits / Q000601:surgery; D013997:Time Factors
chemical_list: D015742:Propofol