A prospective study of chloramphenicol induced aplastic anaemia in Nigerians.
A five-year prospective study of chloramphenicol induced aplastic anaemia in Nigerians was undertaken. Five proven cases were seen, representing 45.5% of all cases of aplastic anaemia diagnosed during the period of study and 1.0 cases per year. Chloramphenicol induced aplastic anaemia is rare (only 0.002% of all new non-obstetric patients seen in the hospital during the period of study) but preventable. Restriction of the drug or its total withdrawal is recommended.
Durosinmi
M A
MA
Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Ajayi
A A
AA
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000453:epidemiology* / Q000517:prevention & control; D002701:Chloramphenicol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D012651:Self Medication
D002701:Chloramphenicol