title: Evaluation of the right atrial venous oxygen saturation as a physiologic monitor in a neonatal model.
abstract: Pulmonary artery (PA) mixed venous saturation (SvO2) has become a crucial monitor in the adult intensive care unit, but is not used in neonates because of the difficulty in PA catheterization. We evaluated the possibility of utilizing the right atrial venous oxygen saturation (RAvO2), which is easily accessed in the neonate, as a monitor of the effects of mechanical ventilation and intravascular volume in an animal model selected to be the size of the human neonate. A continuous RAvO2 monitoring catheter was placed into the right atrium of 16 normal rabbits (2.2 to 4.1 kg). Oxygen delivery was manipulated by alterations in peak inspiratory pressure (PIP) (n = 6), positive end-expiratory pressure (PEEP) (n = 6), or by progressive hypovolemia (n = 4). RAvO2 decreased with onset of mechanical ventilation alone from 69% +/- 6% to 61% +/- 5% (P < .01). As the PIP was increased from 12 to 21 cm H2O, the RAvO2 progressively decreased from 59% +/- 4% to 49% +/- 6% (P < .05). As the PEEP was increased from 3 to 9 cm H2O, the RAvO2 progressively decreased from 64% +/- 5% to 33% +/- 16% (P < .01). RAvO2 approached baseline after return to continuous positive airway pressure (CPAP) of 3 cm H2O. Progressive phlebotomy to a total of 10 mL/kg resulted in a decrease in RAvO2 from 70% +/- 6% to 27% +/- 5% (P < .001). Volume resuscitation resulted in an increase in RAvO2 to near baseline. Peripheral arterial oxygen saturation remained at a constant 100% throughout each protocol.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor.
authors.forename: R B
authors.initials: RB
authors.lastname: Hirschl
authors.forename: P
authors.initials: P
authors.lastname: Palmer
authors.forename: K F
authors.initials: KF
authors.lastname: Heiss
authors.forename: K
authors.initials: K
authors.lastname: Hultquist
authors.forename: F
authors.initials: F
authors.lastname: Fazzalari
authors.forename: R H
authors.initials: RH
authors.lastname: Bartlett
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001158:Arteries; D016280:Atrial Function, Right / Q000502:physiology*; D007384:Intermittent Positive-Pressure Breathing; D008954:Models, Biological; D008991:Monitoring, Physiologic; D010092:Oximetry; D010101:Oxygen Consumption; D011175:Positive-Pressure Respiration; D011817:Rabbits; D014680:Veins; D016278:Ventricular Function, Right / Q000502:physiology*