title: Differential expression of c-fos and c-jun in two regions of the rat spinal cord following noxious colorectal distention.
abstract: Thoracolumbar and lumbosacral spinal segments that receive afferent input from the descending colon and rectum were stained immunocytochemically for c-Fos- and c-Jun-like proteins following repetitive, noxious colorectal distention (CRD). Noxious CRD (80 mmHg) resulted in significantly more c-Fos- and c-Jun-like immunoreactivity in the sacral dorsal horn than in the thoracic dorsal horn. In both regions of the spinal cord the increase in c-Fos-like immunoreactivity was at least twice that of c-Jun-like immunoreactivity. Basal levels of c-Jun but not c-Fos were observed in the thoracic intermediolateral nucleus (IML) and the sacral parasympathetic nucleus (SPN). Noxious CRD induced both c-Fos and c-Jun in the SPN, but not the IML.
authors.affiliation: Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242.
authors.forename: R J
authors.initials: RJ
authors.lastname: Traub
authors.forename: T
authors.initials: T
authors.lastname: Herdegen
authors.forename: G F
authors.initials: GF
authors.lastname: Gebhart
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D003106:Colon / Q000294:innervation / Q000502:physiology*; D005786:Gene Expression Regulation; D016762:Genes, fos; D016758:Genes, jun; D007150:Immunohistochemistry; D008297:Male; D009130:Muscle, Smooth / Q000294:innervation / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D016755:Proto-Oncogene Proteins c-jun / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012007:Rectum / Q000294:innervation / Q000502:physiology*; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun