[Expression of P53 protein in cutaneous melanoma].
P53 protein in cutaneous melanoma. We report the results of an immunohistochemical analysis about the nuclear phosphoprotein P53 expression performed on 48 primary and 10 metastatic cutaneous melanoma in order to assess the prevalence of the expression of mutant P53 protein (m-P53) in this skin tumour. In our study m-P53 was found in about 46% of primary tumours without any significant relationship with the corresponding metastatic lesions. Therefore the P53 count in cutaneous melanoma is not a prognostic marker of tumour spread and aggressiveness.
Casazza
S
S
Servizio di Istologia e Anatomia Patologica, Ospedali Galliera di Genova.
Gambini
C
C
Tunesi
G
G
Rovida
S
S
Caruso
F
F
Pastorino
A
A
Canepa
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000556:secondary*; D008875:Middle Aged; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53
Espressione della proteina P53 nel melanoma cutaneo.