title: Separate acquisition rest thallium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography: a clinical validation study.
abstract: OBJECTIVE
  This study assessed the validity of a novel approach to myocardial perfusion scintigraphy that provides the opportunity to avoid the drawbacks of standard same-day rest/stress technetium-99m sestamibi myocardial perfusion studies by using separate-acquisition dual-isotope rest thallium-201 and exercise technetium-99m sestamibi single-photon emission computed tomography (SPECT).
  
  
  BACKGROUND
  Standard same-day rest/stress technetium-99m sestamibi myocardial perfusion studies are cumbersome, associated with a potential decrease in perceived stress defect severity compared with thallium-201 due to the presence of rest technetium-99m sestamibi and may be unable to differentiate hibernating from infarcted myocardium.
  
  
  METHODS
  The dual-isotope procedure was performed in 63 patients without previous myocardial infarction undergoing coronary angiography to evaluate sensitivity and specificity for coronary artery disease and in 107 patients with a low (< 5%) likelihood of coronary artery disease to evaluate normalcy rate. To validate defect reversibility, the dual-isotope SPECT study was compared with stress/rest technetium-99m sestamibi SPECT studies in a separate group of 31 patients with previous documented myocardial infarction who underwent a rest technetium-99m sestamibi study in addition to the dual-isotope SPECT study.
  
  
  RESULTS
  In angiographic correlations, dual-isotope SPECT demonstrated high sensitivity for detecting patients with > or = 50% stenosis (91%, 55 patients) and > or = 70% stenosis (96%, 52 patients). In a small group of patients, high specificity was also observed (75% for < 50% stenosis [8 patients] and 82% for < 70% stenosis [11 patients]). A very high normalcy rate of 95% was also found. In the patient group assessed for defect reversibility, in zones with no previous myocardial infarction, segmental agreement for defect type between rest thallium-201 and rest technetium-99m sestamibi studies was 97% (kappa = 0.79, p < 0.001). In myocardial infarct zones, segmental agreement for defect type was 98% (kappa = 0.93, p < 0.001). Image quality was generally good to excellent.
  
  
  CONCLUSIONS
  Our findings demonstrate that separate-acquisition dual-isotope myocardial perfusion SPECT is accurate for coronary artery disease detection, correlates well with rest-stress sestamibi studies for assessment of defect reversibility and results in good to excellent image quality. This approach provides an excellent method for the combined assessment of stress myocardial perfusion and myocardial viability.
authors.affiliation: Department of Imaging (Division of Nuclear Medicine), Cedars-Sinai Medical Center, Los Angeles, California 90048.
authors.forename: D S
authors.initials: DS
authors.lastname: Berman
authors.forename: H
authors.initials: H
authors.lastname: Kiat
authors.forename: J D
authors.initials: JD
authors.lastname: Friedman
authors.forename: F P
authors.initials: FP
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: van Train
authors.forename: L
authors.initials: L
authors.lastname: Matzer
authors.forename: J
authors.initials: J
authors.lastname: Maddahi
authors.forename: G
authors.initials: G
authors.lastname: Germano
mesh_terms: D000368:Aged; D002985:Clinical Protocols; D003327:Coronary Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015203:Reproducibility of Results; D012146:Rest; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017256:Technetium Tc 99m Sestamibi / Q000008:administration & dosage / Q000191:economics; D013794:Thallium Radioisotopes / Q000008:administration & dosage / Q000191:economics; D015899:Tomography, Emission-Computed, Single-Photon / Q000191:economics / Q000379:methods*
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi