Histone H1t: a tissue-specific model used to study transcriptional control and nuclear function during cellular differentiation.
One of the most prominent and best studied family of genes is the histone gene family. In recent years, histone gene regulation during the cell cycle of somatic cells has been studied extensively. This paper is intended to highlight and emphasize recent data concerning the tissue-specific expression of histone H1t using spermatogenesis as a model system. In this article we describe a unique DNA element within the proximal promoter of the histone H1t gene. This element has been shown to bind exclusively to nuclear proteins from pachytene spermatocytes and early spermatids. Thus, there is a strong temporal correlation between the appearance of the testis-specific DNA-binding protein and the onset of transcription of the testis-specific histone H1t gene.
Wolfe
S A
SA
Research Service, VA Medical Center, Shreveport, Louisiana.
Grimes
S R
SR
D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000502:physiology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006657:Histones / Q000235:genetics* / Q000502:physiology; D008297:Male; D009687:Nuclear Proteins; D011401:Promoter Regions, Genetic; D013091:Spermatogenesis; D013737:Testis / Q000378:metabolism; D014158:Transcription, Genetic
D006657:Histones; D009687:Nuclear Proteins; D004247:DNA