[Mitotic cyclins--new possibilities for examining mechanisms of neoplasm growth].
Mitotic cyclins constitute a regulatory subunit of the histone H1 kinase complex. On the ground of their primary structure they are divided into two classes A and B, both necessary for the mitosis. Cyclin A activates histone H1 kinase and becomes destroyed by proteolysis earlier than cyclines B and plays an important role in the DNA replication. Cyclins A and B may be involved in the development of neoplastic disorders either directly (inappropriate expression of the cyclin A gene caused by hepatitis B virus in hepatocellular carcinoma, or interactions of this cyclin with factors participating in the regulation of cell proliferation) or indirectly by phosphorylation of some oncogene or antioncogene proteins by a cdk (cyclin dependent kinase).
Wołowiec
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Katedra i Klinika Hematologii i Chorób Rozrostowych Akademii Medycznej, Wrocławiu.
Ffrench
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D000818:Animals; D002455:Cell Division / Q000502:physiology; D016213:Cyclins / Q000502:physiology*; D006801:Humans; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000503:physiopathology*
D016213:Cyclins
Cykliny mitotyczne: nowe mozliwości w badaniach mechanizmów rozrostów nowotworowych.