Retinoids in chemoprevention of head and neck carcinogenesis.
There is currently considerable excitement about the prospects of developing effective chemoprevention strategies for head and neck cancer. The field cancerization model provides the basic assumptions which guide current head and neck chemoprevention trials. The retinoid 13-cis-retinoic acid, as well as other agents, is currently being studied in clinical trials and will hopefully establish the role of chemoprevention in head and neck cancer.
Lippman
S M
SM
Department of Thoracic/Head and Neck Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Benner
S E
SE
Hong
W K
WK
D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006258:Head and Neck Neoplasms / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007972:Leukoplakia, Oral / Q000209:etiology / Q000517:prevention & control; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000517:prevention & control; D011230:Precancerous Conditions / Q000209:etiology / Q000517:prevention & control; D012176:Retinoids / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D012176:Retinoids