title: Cyclosporine A induced colitis and acquired selective IgA deficiency in a patient with juvenile chronic arthritis.
abstract: A 12-year-old girl with juvenile chronic arthritis was treated with cyclosporine A for recurrent uveitis. Two years later she presented with weight loss and diarrhea. Investigations suggested drug induced colitis. She improved after withdrawal of cyclosporine and her nonsteroidal antiinflammatory drug. Symptoms recurred on rechallenge with cyclosporine. She has developed a progressive selective IgA deficiency which persists despite cessation of cyclosporine.
authors.affiliation: Department of Gastroenterology, Glasgow Royal Infirmary, Scotland.
authors.forename: E A
authors.initials: EA
authors.lastname: Murphy
authors.forename: A J
authors.initials: AJ
authors.lastname: Morris
authors.forename: E
authors.initials: E
authors.lastname: Walker
authors.forename: F D
authors.initials: FD
authors.lastname: Lee
authors.forename: R D
authors.initials: RD
authors.lastname: Sturrock
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications*; D002648:Child; D003092:Colitis / Q000139:chemically induced* / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000139:chemically induced*; D009288:Naproxen / Q000627:therapeutic use; D014605:Uveitis / Q000150:complications / Q000188:drug therapy*
chemical_list: D009288:Naproxen; D016572:Cyclosporine