[Morphometric evaluation on the pathologic changes in ovariectomized endometria influenced by estrogen use].
Thirty SD female rats were divided into the following groups: (1) sham operation; (2) bilateral ovariectomized (OVX); (3) OVX and estrogen-treated (E). Computerized Image Analyser was used to evaluate the pathologic changes of endometria in these animals. The results showed the endometria of OVX group was in the state of atrophia, while the endometria of E group was in the state of early proliferative stage. The heights of endometria, endometrial epithelia cells and gland epithelia cells, the volume fraction and numerical density of endometrial glands, and the cavity diameter of the glands could effectively express the proliferative changes of the endometria. It is suggested that this method be used to study the pathology of the different endometric diseases.
Tan
J
J
Li
H
H
Liu
H
H
Yang
S
S
D000818:Animals; D001284:Atrophy; D001699:Biometry; D004717:Endometrium / Q000473:pathology*; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D007091:Image Processing, Computer-Assisted; D009929:Organ Size; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000473:pathology
D004958:Estradiol