Vessel-like structures in the callus cartilage.
The recent claim that the callus cartilage contained vessel-like structures has been investigated by new immunocytochemical methods. The fracture callus was exposed to monoclonal antibodies which recognized damaged or regenerating endothelial cells. The proteolytic enzyme urokinase which is expressed by migrating endothelium was also studied. No vascular structures were identified by these methods which suggests that the callus cartilage is truly avascular.
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University Department of Orthopaedic Surgery, Glenfield General Hospital, Leicester, UK.
Pringle
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D000328:Adult; D000911:Antibodies, Monoclonal; D002146:Bony Callus / Q000098:blood supply*; D002356:Cartilage / Q000098:blood supply*; D004730:Endothelium, Vascular / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D013978:Tibial Fractures / Q000473:pathology; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis
D000911:Antibodies, Monoclonal; D014568:Urokinase-Type Plasminogen Activator