title: Myocardial and circulatory performance during the ischemic phase of superior mesenteric artery occlusion.
abstract: OBJECTIVE
  To investigate myocardial and circulatory parameters during the acute ischemic phase of mesenteric artery occlusion.
  
  
  METHODS
  A prospective, randomized, control trial.
  
  
  METHODS
  Twelve, adult, mongrel dogs.
  
  
  METHODS
  In seven dogs the superior mesenteric artery was occluded with two silk ligatures (experimental group). In five dogs the ligatures were not tied (control group). Measurements were made during 7 hours of occlusion.
  
  
  METHODS
  Myocardial performance and circulatory performance.
  
  
  RESULTS
  There were significant (p < 0.05) reductions in arterial blood pressure, mean pulmonary artery pressure, diastolic pulmonary artery pressure and cardiac index in dogs exposed to intestinal ischemia compared with the control dogs. No differences were identified in ventricular performance, stroke volume index or peripheral vascular resistance index.
  
  
  CONCLUSIONS
  Early cardiac and central circulatory changes in massive intestinal ischemia are due to intravascular hypovolemia. Sepsis and myocardial depressant factors were not found to be a cause of death.
authors.affiliation: Division of Vascular Surgery, Victoria Hospital and the University of Western Ontario, London.
authors.forename: W G
authors.initials: WG
authors.lastname: Jamieson
authors.forename: G
authors.initials: G
authors.lastname: DeRose
authors.forename: K A
authors.initials: KA
authors.lastname: Harris
authors.forename: G
authors.initials: G
authors.lastname: Pliagus
authors.forename: L
authors.initials: L
authors.lastname: Stafford
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000503:physiopathology; D017538:Mesenteric Artery, Superior; D008641:Mesenteric Vascular Occlusion / Q000503:physiopathology*; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000503:physiopathology; D011897:Random Allocation; D013318:Stroke Volume; D014655:Vascular Resistance; D016276:Ventricular Function