[The participation of the neuraminidase of Yersinia pestis in the transmission of the transmembrane signal].
Neuraminidase isolated from Yersinia pestis [correction of the plaque microbe] and purified has been studied for its effect on the peritoneal leukocytes of the white mice with results presented. Neuraminidase exerted the insulin-like effect on the peritoneal leukocytes of the white mice and this effect depended on the used dose. The priming of leukocytes by neuraminidase preparation was accompanied by the sharp increase of hydrogen peroxide production under effect of the capsule antigen of the plaque microbe and, apparently, by the appearance of additional binding sites for the adhesion piles of the plaque agent.
Aseeva
L E
LE
Mishan'kin
B N
BN
Shimaniuk
N Ia
NIa
Rublev
B D
BD
Vodop'ianov
S O
SO
D000818:Animals; D002250:Carbon Radioisotopes; D004926:Escherichia coli; D007328:Insulin / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008163:Luminescent Measurements; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009439:Neuraminidase / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D010529:Peritoneal Cavity / Q000166:cytology; D015398:Signal Transduction / Q000187:drug effects; D015010:Yersinia pestis / Q000201:enzymology*
D002250:Carbon Radioisotopes; D007328:Insulin; D009439:Neuraminidase
Uchastie neĭraminidazy chumnogo mikroba v peredache transmembrannogo signala.