[Effects of the stimulation of the subthalamic nucleus in Parkinson disease].
In Parkinson's disease, experimental studies favour a neuronal hyperactivity of the subthalamic nucleus. We carried out a subthalamic nucleus electrical stimulation in a patient aged 51, suffering for 8 years from a severe akineto-rigid form of Parkinson's disease, complicated with an on-off effect. Stereotaxic surgery was done under local anaesthesia on one side. Within the theoretical target, a 130 Hz stimulation induced akinesia alleviation mainly on the contralateral limbs. No abnormal movement was noticed. Then a long-term quadripolar DBS Medtronic electrode was inserted in that area. The study of the effects of chronic stimulation is in progress to determine the best temporal and electrical stimulation variables.
Pollak
P
P
Département des Neurosciences Cliniques et Biologiques, Centre Hospitalier Universitaire de Grenoble, France.
Benabid
A L
AL
Gross
C
C
Gao
D M
DM
Laurent
A
A
Benazzouz
A
A
Hoffmann
D
D
Gentil
M
M
Perret
J
J
D004599:Electric Stimulation Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000628:therapy; D010300:Parkinson Disease / Q000628:therapy*; D013787:Thalamic Nuclei
Effets de la stimulation du noyau sous-thalamique dans la maladie de Parkinson.