title: 99Tcm-labelled polyclonal human immunoglobulin G scintigraphy before and after intra-articular knee injection of triamcinolone hexacetonide in patients with rheumatoid arthritis.
abstract: The ability of 99Tcm-labelled polyclonal human immunoglobulin G (99Tcm-IgG) scintigraphy to monitor intra-individual variation in arthritis activity was studied in seven patients with rheumatoid arthritis (RA). These patients were treated with an intra-articular injection of 20 mg triamcinolone hexacetonide. The results of semiquantitative 99Tcm-IgG scintigraphy were compared with the degree of joint swelling and the histological changes observed in synovial biopsies before and 14 days after the injection. In all seven patients the local treatment resulted in a decreased arthritis activity of the treated knee as measured clinically or histologically. This decrease was parallelled, in all patients except one, by a lower uptake of 99Tcm-IgG after the injection when compared to uptake prior to treatment. This study shows that 99Tcm-IgG scintigraphy is able to reflect intra-individual variations in arthritis activity in patients with RA.
authors.affiliation: Department of Rheumatology, University Hospital, Leiden, The Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: de Bois
authors.forename: J W
authors.initials: JW
authors.lastname: Arndt
authors.forename: P P
authors.initials: PP
authors.lastname: Tak
authors.forename: P M
authors.initials: PM
authors.lastname: Kluin
authors.forename: E A
authors.initials: EA
authors.lastname: van der Velde
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007136:Immunoglobulins; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013667:Technetium; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D007136:Immunoglobulins; C065376:technetium Tc 99m immunoglobulin; D013667:Technetium; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide