title: The morphofunctional characteristics of neurons of the sensorimotor cortex of aged rabbits during the trace assimilation of rhythm.
abstract: The formation of trace rhythm assimilation (an analog of the conditioned reflex to time) by neurons of the sensorimotor cortex in response to prolonged (10-20 min) electrodermal stimulation of an extremity at a frequency of 0.5-1 or 2 Hz was investigated in awake adult (5-7 months), old (54-65 months), and very old (66-85 months) rabbits. The data of the spectral analysis of the impulse activity of 460 neurons showed aged-related differences in the formation of trace rhythm assimilation by neurons: it takes place after one to two series (1st to 2nd days of the experiment) in young animals; after two to four series of periodic stimulation (2nd to 3rd days of the experiment) in the old animals; in very old animals rhythmic stimulation essentially did not result in rhythm assimilation by cortical neurons. Quantitative and qualitative morphological changes in nerve and glial cells in the sensorimotor cortex of old rabbits as compared with young rabbits were identified. It is hypothesized that deviations in the course of mnestic processes observed in animals during aging may be associated with destructive phenomena in the neocortex during normal aging.
authors.affiliation: Institute of the Brain, Russian Academy of Medical Sciences, Moscow.
authors.forename: F V
authors.initials: FV
authors.lastname: Kopytova
authors.forename: G N
authors.initials: GN
authors.lastname: Krivitskaya
authors.lastname: Mednikova YuS
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D004558:Electric Stimulation; D009044:Motor Cortex / Q000166:cytology* / Q000502:physiology; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011817:Rabbits; D012879:Skin Physiological Phenomena; D013003:Somatosensory Cortex / Q000166:cytology* / Q000502:physiology