In vitro evaluation of the activities of azithromycin alone and combined with pyrimethamine against Toxoplasma gondii.
By using an in vitro microassay to assess drug interaction, azithromycin combined to pyrimethamine was found more active than pyrimethamine alone against Toxoplasma gondii, and additivity between those drugs was demonstrated. Our results show that the combination of azithromycin and pyrimethamine may lead to a more rapid control of T. gondii.
Cantin
L
L
Laboratoire et Service d'Infectiologie, Centre de Recherche du Centre Hospitalier, Université Laval, Québec, Canada.
Chamberland
S
S
D000818:Animals; D017963:Azithromycin / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011739:Pyrimethamine / Q000494:pharmacology; D013416:Sulfamerazine / Q000494:pharmacology; D014122:Toxoplasma / Q000187:drug effects*; D014498:Uracil / Q000378:metabolism
D014498:Uracil; D017963:Azithromycin; D013416:Sulfamerazine; D011739:Pyrimethamine