title: Chronic effects of SQ29,852, a new angiotensin converting enzyme (ACE) inhibitor with a phosphonic acid group, in experimental hypertensive rats.
abstract: 1. Chronic effects on blood pressure of SQ29,852 administered daily for 21 consecutive days were compared to those of captopril and enalapril in spontaneously hypertensive (SHR) and two-kidney-one-clip renal hypertensive (CLIP) rats. 2. SQ29,852 showed significant chronic anti-hypertensive effects at 30 mg/kg in SHR and at 10 mg/kg in CLIP rats. Chronic anti-hypertensive effects of SQ29,852 were in-between those of enalapril and captopril. 3. Significant anti-hypertensive effects lasted in enalapril-treated SHR for 7 days after discontinuation of treatment, while only a tendency toward persistence of anti-hypertensive effects was noted in all animals treated with SQ29,852 and captopril.
authors.affiliation: Department of Pharmacology, Jichi Medical School, Tochigi-ken, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D004656:Enalapril / Q000494:pharmacology; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D009943:Organophosphorus Compounds; D004656:Enalapril; D011392:Proline; D002216:Captopril; C054518:ceronapril