title: Evaluation of liver function and lipid metabolism following Norplant-2 rods removal.
abstract: The effect of Norplant-2 rods on liver function and lipid metabolism was evaluated in 100 Singaporean women. As with the Norplant six-capsule, the only change noted in liver function was that of a significantly elevated bilirubin, which was within the normal clinical range for the local population. As regards lipid metabolism, the mean values for total triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol seen at the end of five years of Norplant-2 rod use and six months postremoval were similar to the preinsertion mean. As a result, the HDL-cholesterol/total-cholesterol-HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratio remained fairly constant. This indicates that the use of Norplant-2 rods does not directly contribute to cardiovascular risk.
authors.affiliation: Department of Obstetrics and Gynecology, National University Hospital, Singapore.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: D F
authors.initials: DF
authors.lastname: Loke
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D001663:Bilirubin / Q000097:blood; D002318:Cardiovascular Diseases / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004343:Drug Implants; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D012307:Risk Factors; D012846:Singapore; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004343:Drug Implants; D008055:Lipids; D014280:Triglycerides; D016912:Levonorgestrel; D002784:Cholesterol; D001663:Bilirubin