[The characteristics of the chromosomal apparatus and functional state of the thyroid in amenorrhea in women].
Girls-teenagers and women with menstrual disturbances were examined cytogenetically and clinically with special respect to the thyroid function. The rate of chromosomal pathology in the studied group was 29.5%. The rate of aberrant cells proved to be elevated in cases of primary and secondary amenorrhea as compared with the control. Chromatid aberrations were typical of the Turner syndrome (8.1% as against 2.1% in controls). In cases of menstrual disturbances the C-segment macrovariants were detected in chromosomes 9 and 16, so as inverted C-segments. The thyroid hyperplasia of the 1st, 2nd stages was detected at the rate of 81.2% among the teenaged girls with menstrual disturbances and TSH-hypophysis-hyperfunction was typical of women with primary or secondary amenorrhea, providing evidence for the secondary origin of thyroid hormonal disturbances.
Shloma
D V
DV
Sozans'kyĭ
O O
OO
Huleiuk
N L
NL
Akopian
H R
HR
Nevzhoda
N V
NV
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000453:epidemiology / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D002869:Chromosome Aberrations / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D010641:Phenotype; D013961:Thyroid Gland / Q000503:physiopathology*
Osoblyvosti khromosomnoho aparatu ta funktsional'noho stanu shchitovydnoï zalozy pry amenoreiakh u zhinok.