Antioxidant protection of bio-normalizer in cerebral ischaemia-reperfusion injury in the gerbil.
In this study we used cerebral ischaemia-reperfusion injury (IRI) as an experimental model to analyse the effects of Bio-normalizer (BN, a naturally fermented health food product) on reactive oxygen species related changes in different brain regions of gerbils. Pre-administration of BN solutions (0.1% and 1%) for 45 days produced a significant reduction in IRI-mediated increase in membrane lipid peroxidation, as shown by the decreased carbon-centred radicals and thiobarbituric acid-reactive substances in several brain regions including the cerebral cortex, the hippocampus and the striatum. BN however has no effect on the mitochondrial superoxide dismutase activity.
Santiago
L A
LA
Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan.
Osato
J A
JA
Ogawa
N
N
Mori
A
A
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D005470:Fluorometry; D016166:Free Radical Scavengers; D005849:Gerbillinae; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D016166:Free Radical Scavengers; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase