Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats.
Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.
Yoshiyama
Y
Y
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Nishikawa
S
S
Sugiyama
T
T
Kobayashi
T
T
Shimada
H
H
Tomonaga
F
F
Ohdo
S
S
Ogawa
N
N
Nakano
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D002940:Circadian Rhythm; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D007279:Injections, Subcutaneous; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D005839:Gentamicins; C016927:isepamicin