Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
Three novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A1 inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B1 was similarly cytotoxic, while quinolidomicin A2 was inactive against these tumor cells.
Hayakawa
Y
Y
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Matsuoka
M
M
Shin-ya
K
K
Seto
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D005285:Fermentation; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008847:Micromonospora / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides; C084379:quinolidomicin A2; C084380:quinolidomicin B1; C084378:quinolidomicin A1