Comparative study of the interactions of cisplatin and carboplatin with nucleotides using UV resonance Raman spectroscopy.
We have obtained the UV excited resonance Raman spectra of five mononucleotides bound to cisplatin and to carboplatin using excitation in resonance with the first electronic absorption bands of the nucleotide bases. Substantial changes in the spectra are observed following interaction with both platinum drugs, indicating modifications to nucleotide structure. Pt (II) binds to base portions of the nucleotide molecules, altering their normal modes of vibration significantly. We present comparative data of cisplatin and carboplatin, and discuss the implications of these results. The kinetics of the drug/nucleotide reactions differ, but final products are found to be similar.
Benson
R L
RL
Department of Chemistry, Ohio State University, Columbua 43210-1173.
Gustafson
T L
TL
D016190:Carboplatin / Q000737:chemistry* / Q000494:pharmacology*; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology*; D004347:Drug Interactions; D009711:Nucleotides / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman
D009711:Nucleotides; D016190:Carboplatin; D002945:Cisplatin