title: Acute haemodynamic effects of isradipine in hypertensive heart transplant recipients.
abstract: The acute haemodynamic effects of the new calcium antagonist isradipine have been studied in ten hypertensive cardiac transplant recipients. Isradipine 0.01 mg.kg-1 was given IV during right heart catheterization and noninvasively automatic blood pressure measurements. From a baseline blood pressure of 164/114 mmHg the maximum blood pressure reduction was 35 mmHg systolic, 30 mmHg diastolic, and mean 34 mmHg, due to a reduction in systemic vascular resistance, maximum 43%. Cardiac index increased 32%, mainly due to an increase in the stroke volume, as the heart rate rose only by 10%. Left ventricular filling pressure was slightly reduced. We conclude that the main effect of isradipine was a major reduction in left ventricular afterload, comparable to that previously found in other patient groups.
authors.affiliation: Medical Department B, Rikshospitalet, Oslo, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Aass
authors.forename: S
authors.initials: S
authors.lastname: Simonsen
mesh_terms: D016027:Heart Transplantation; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007262:Infusions, Intravenous; D017275:Isradipine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged
chemical_list: D017275:Isradipine