Structure of fischerin, a new toxic metabolite from an ascomycete, Neosartorya fischeri var. fischeri.
A new toxic metabolite named fischerin [1] from an Ascomycete. Neosartorya fischeri var. fischeri, which caused lethal peritonitis in mice, was deduced to have a structure including a 1,4-dihydroxy-3,5-disubstituted-2(1H)-pyridone moiety by chemical and spectral data.
Fujimoto
H
H
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Ikeda
M
M
Yamamoto
K
K
Yamazaki
M
M
D000107:Acetylation; D000818:Animals; D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism*; D006865:Hydrogenation; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D051379:Mice; D009183:Mycotoxins / Q000737:chemistry* / Q000633:toxicity; D009281:Naphthalenes / Q000737:chemistry* / Q000633:toxicity; D011728:Pyridones / Q000737:chemistry* / Q000633:toxicity
D009183:Mycotoxins; D009281:Naphthalenes; D011728:Pyridones; C083903:fischerin