Response of the human neurogenic bladder to KCl, carbachol, ATP and CaCl2.
The in vitro pharmacological responses of the human neurogenic bladder to KCl, carbachol, ATP and CaCl2 have been analysed. The contractility (contractile strength and ED50) of neurogenic bladders was significantly increased when treated with carbachol, ATP and CaCl2. In contrast, there was no apparent difference in the responsiveness of neurogenic bladders when treated with KCl. There was no apparent correlation between pharmacological responsiveness and clinical parameters, such as gender, age or cystometric data, in the neurogenic bladders.
Saito
M
M
Department of Urology, Nagoya University School of Medicine, Japan.
Kondo
A
A
Kato
T
T
Hasegawa
S
S
Miyake
K
K
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D002122:Calcium Chloride / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects*; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology*
D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D002217:Carbachol; D002122:Calcium Chloride