[The preventive effect of additional albumin in crystalloid cardioplegic solution on myocardial reperfusion injury].
The effect of additional albumin in crystalloid cardioplegic solution (CS) was investigated for infant with open heart surgery. Patients were divided into two groups; CS containing with or without 1% albumin. CS without albumin was administered for Group-I in 13 patients and CS with albumin for Group-II in 14 patients. The blood samples were collected from radial artery and coronary sinus at 5, 15 and 30 minutes after reperfusion and blood gas analysis, hemoglobin, lactate, creatine kinase-MB (CK-MB) and malondialdehyde (MDA) were measured. In percentage of CK-MB secretion, no significant differences were seen between two groups. However, in oxygen consumption, lactate and MDA secretion, significant differences between the groups were noted at five minutes after reperfusion. In conclusion, additional albumin in CS solution, especially in infant cases was effective for myocardial preservation immediately after reperfusion.
Hisatomi
K
K
Second Department of Surgery, Kurume University School of Medicine, Japan.
Kosuga
K
K
Isomura
T
T
Hirano
A
A
Sato
S
S
Aoyagi
S
S
Oishi
K
K
D000418:Albumins / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes; D007773:Lactates / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D017680:Potassium Compounds / Q000008:administration & dosage*
D000418:Albumins; D007527:Isoenzymes; D007773:Lactates; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D008315:Malondialdehyde; D003402:Creatine Kinase