Congenital bilateral juvenile granulosa cell tumor of the ovary in leprechaunism: a case report.
We report on a case of leprechaunism. In addition to the typical clinical and biochemical features, a bilateral juvenile granulosa cell tumor of the ovaries and cytomegalovirus hepatitis were found. The granulosa cell tumor may result from the mitogenic effect of insulin at high concentration, which acts via a mechanism mediated by insulin-like growth factor I receptors.
Brisigotti
M
M
Department of Pathology, Children's Hospital G. Gaslini Institute, Genoa-Quarto, Italy.
Fabbretti
G
G
Pesce
F
F
Gatti
R
R
Cohen
A
A
Parenti
G
G
Callea
F
F
D003586:Cytomegalovirus Infections / Q000150:complications / Q000473:pathology; D005145:Face / Q000002:abnormalities; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000473:pathology; D006130:Growth Disorders / Q000150:complications* / Q000235:genetics; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000473:pathology; D006628:Hirsutism / Q000150:complications / Q000235:genetics; D006801:Humans; D007223:Infant; D007333:Insulin Resistance / Q000235:genetics; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D013577:Syndrome