title: [A case of complete remission of metastatic skin carcinoma (erythema type) from advanced gastric cancer by CDDP administration].
abstract: A 75-year-old female with skin metastasis from advanced gastric cancer (portion A, tub2, ss beta, n2, P0H0, Borrmann 3-type) was successfully treated with CDDP at a dosage of 25 mg/body every week or two. She had undergone R2 curative subtotal gastrectomy in October 1986, and had orally taken tegafur 300 mg/day as postoperative adjuvant chemotherapy. Three years after the operation, she had skin erythema at chest and neck. A pathological examination revealed that the skin erythema was a metastasis of gastric cancer. After administration of 5-FU and MMC, the skin lesion diminished in size, but in November of 1990, it expanded again. Administration of 5-FU, MMC and epirubicin was not effective. The skin lesion expanded extensively and changed to nodular type. CDDP was intermittently administered from August 1991 to December 1991, 25 mg/body div. every week or two; the total volume of CDDP reached 225 mg. The metastatic skin carcinoma disappeared and a complete response was obtained. CEA, which had been high (190 ng/ml), regained the normal level. Thrombocytopenia and liver dysfunction developed as side effects, but reduced after cessation of CDDP administration. The patient has been well for 3 years and 6 months since the onset of the skin metastasis.
authors.affiliation: Dept. of Surgery, Kyoto Prefectural Yosanoumi Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.forename: K
authors.initials: K
authors.lastname: Naito
authors.forename: A
authors.initials: A
authors.lastname: Tsuruta
authors.forename: K
authors.initials: K
authors.lastname: Kan
authors.forename: S
authors.initials: S
authors.lastname: Toda
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmori
authors.forename: T
authors.initials: T
authors.lastname: Oka
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D000368:Aged; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D002945:Cisplatin