Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard reaction, in diabetic serum.
3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic complications such as diabetic nephropathy by promoting the formation of advanced glycation end products.
Niwa
T
T
Department of Clinical Laboratory, Nagoya University Branch Hospital, Japan.
Takeda
N
N
Yoshizumi
H
H
Tatematsu
A
A
Ohara
M
M
Tomiyama
S
S
Niimura
K
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003432:Cross-Linking Reagents; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D015416:Maillard Reaction; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D015415:Biomarkers; D003432:Cross-Linking Reagents; C060458:3-deoxyglucose; D003847:Deoxyglucose