title: Regulation of calcitonin secretion in vitro.
abstract: The concentration of extracellular calcium rightly regulates calcitonin secretion by calcium influx through dihydropyridine-sensitive voltage-dependent calcium channels; the result is an increase in intracellular calcium. There also exists a cAMP-dependent pathway of calcitonin release activated by glucagon or growth hormone releasing hormone. In thyroid C-cells, as in all cells, there is dual regulation of adenylate cyclase, mediated by inhibitory or stimulatory G proteins; glucagon stimulated cAMP production can be inhibited by somatostatin via pertussis toxin sensitive inhibitory G proteins. Somatostatin inhibits not only cAMP dependent but also calcium-dependent calcitonin secretion. Furthermore, somatostatin inhibits voltage dependent calcium channel currents thereby lowering cytosolic calcium. These actions also involve a pertussis toxin-sensitive inhibitory G protein but they occur independently of changes in the cytosolic cAMP concentration. Thus multiple interactions between second messenger systems at different cellular levels modulate calcitonin secretion.
authors.affiliation: Abt. Innere Medizin I, Endokrinologie und Stoffwechsel, Universität Heidelberg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Raue
authors.forename: A
authors.initials: A
authors.lastname: Zink
authors.forename: H
authors.initials: H
authors.lastname: Scherübl
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D006801:Humans
chemical_list: D002116:Calcitonin; D002118:Calcium