title: [Treatment of mild hypertension with captopril and captopril with hydrochlorothiazide. Impact on blood pressure values and quality of life].
abstract: The effects of captopril alone or associated to hydrochlorothiazide on blood pressure and quality of life was studied in 244 hypertensive subjects. After a medication wash out period of 30 days (and 7 additional days when diuretics were used) patients were treated initially with captopril 25 mg b.i.d. (scheme A); if blood pressure was not normalized, hydrochlorothiazide 25 mg o.d. was added (scheme B) and the dose of captopril was increased to 50 mg bid (scheme C) in a stepwise fashion. Sixteen patients (6.6%) were lost from follow up; in the rest a significant reduction of blood pressure was obtained at the end of the treatment period (from 163/98.9 +/- 19.7/3.1 to 143/85 +/- 12.7/6.7 p < 0.05), without changes in cardiac frequency. Using captopril alone, blood pressure was normalized at 15 and 75 days in 62.9 and 70.6% of patients respectively. With captopril plus hydrochlorothiazide blood pressure was normalized in 80.9% of patients. Quality of life improved significantly from of 42.8 +/- 1.7 to 50.7 +/- 15 score points (p < 0.05) secondary effects were observed in 7.4% of patients. It is concluded that captopril alone or associated to hydrochlorothiazide is effective in the treatment of mild hypertension, produces few secondary effects and improves the quality of life.
authors.affiliation: Departamento de Medicina, Hospital del Salvador, Facultad de Medicina Universidad de Chile, Santiago de Chile.
authors.forename: E
authors.initials: E
authors.lastname: Escobar
authors.forename: E
authors.initials: E
authors.lastname: Roessler
authors.forename: H
authors.initials: H
authors.lastname: Zarate
authors.forename: O
authors.initials: O
authors.lastname: Román
authors.forename: G
authors.initials: G
authors.lastname: Valdés
authors.forename: E
authors.initials: E
authors.lastname: Medina
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D002985:Clinical Protocols; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011788:Quality of Life
chemical_list: D006852:Hydrochlorothiazide; D002216:Captopril
vernacular_title: Tratamiento de la hipertensión leve con captopril y captopril e hidroclorotiazida. Impacto en cifras tensionales y calidad de vida.