Renal transplantation in young boys with posterior urethral valves: preliminary report.
Seven boys (mean age 38 months) with posterior urethral valves underwent renal transplantation between June 1988 and August 1991. Urodynamic studies were performed before transplantation in 6/7 patients. In 4 the investigation indicated bladders of capacity and compliance which were deemed suitable for transplantation. Two patients had poorly compliant bladders; one of these underwent bladder augmentation before engraftment and the other proceeded to transplantation without bladder surgery. Six patients have functioning renal allografts with a mean follow-up of 1.3 years and a mean plasma creatinine of 51.6 mumol/l. Mean glomerular filtration rate (ml/min/1.73 m2 SA) 6 months after transplantation was 76.8 and at 1 year it was 84.5. In one patient early rejection was followed by transplant nephrectomy. Careful pre-operative evaluation is mandatory for a successful outcome of renal transplantation in young boys with posterior urethral valves.
Dinneen
M D
MD
Department of Paediatric Urology, Hospital for Sick Children, London.
Fitzpatrick
M M
MM
Godley
M L
ML
Dicks-Mireaux
C M
CM
Ransley
P G
PG
Fernando
O N
ON
Trompeter
R S
RS
Duffy
P G
PG
D001827:Body Height / Q000502:physiology; D002675:Child, Preschool; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D011184:Postoperative Period; D011300:Preoperative Care; D012189:Retrospective Studies; D014521:Urethra / Q000002:abnormalities*; D001743:Urinary Bladder / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology