Sequence of an exon of the feline p53 gene--mutation in a lymphosarcoma.
Exon 8 of tumour suppressor gene p53 was sequenced in domestic cats and showed remarkable similarity to the human sequence. Only four of the 13 nucleotide differences gave rise to interspecific amino acid differences. In an investigated lymphosarcoma we detected a mutation cgg --> tgg (arginine --> tryptophan) in codon no. 282.
Mayr
B
B
Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.
Heczko
U
U
Schellander
K
K
Schleger
W
W
Reifinger
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002371:Cat Diseases / Q000235:genetics* / Q000473:pathology; D002415:Cats; D003062:Codon; D005091:Exons; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D017386:Sequence Homology, Amino Acid
D003062:Codon