title: Adrenergic regulation of renin secretion and renal hemodynamics during deliberate hypotension in humans.
abstract: To assess the relative contributions of neural and nonneural stimuli of renin secretion, the effects of an alpha 1-agonist, phenylephrine (Phe), or a beta-agonist, epinephrine (Epi), on plasma renin activity (PRA), renal blood flow (RBF), and glomerular filtration rate (GFR) were compared during sympathetic blockade with epidural hypotensive anesthesia [mean arterial blood pressure (MAP) = 60 and 50 mmHg]. Controls (NaCl) received saline alone to maintain MAP at 50 mmHg. Epi increased PRA (ng.ml-1.h-1) from 0.9 +/- 0.6 to 3.0 +/- 1.5 at 60 mmHg MAP and 4.7 +/- 1.8 at 50 mmHg MAP, with associated decreases in RBF (-33 and -60%, respectively) and GFR (-27 and -53%, respectively). During hypotension with Phe and NaCl, PRA and RBF were unchanged from baseline but GFR decreased. Urinary Na secretion decreased comparably in all three groups. In conclusion, during sympathetic blockade with epidural anesthesia, marked reductions in both renal perfusion pressure and distal nephron Na delivery were insufficient to increase renin secretion. beta-Adrenergic stimulation (e.g., Epi) was required to increase PRA. Epi decreased RBF suggesting an angiotensin II-mediated effect.
authors.affiliation: Department of Anesthesiology, Hospital for Special Surgery, New York, New York.
authors.forename: V M
authors.initials: VM
authors.lastname: Zayas
authors.forename: J D
authors.initials: JD
authors.lastname: Blumenfeld
authors.forename: B
authors.initials: B
authors.lastname: Bading
authors.forename: M
authors.initials: M
authors.lastname: McDonald
authors.forename: G D
authors.initials: GD
authors.lastname: James
authors.forename: Y F
authors.initials: YF
authors.lastname: Lin
authors.forename: N E
authors.initials: NE
authors.lastname: Sharrock
authors.forename: J E
authors.initials: JE
authors.lastname: Sealey
authors.forename: J H
authors.initials: JH
authors.lastname: Laragh
mesh_terms: D000767:Anesthesia, Epidural; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006622:Hip Prosthesis; D006801:Humans; D007022:Hypotension / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000502:physiology*; D010656:Phenylephrine / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects* / Q000502:physiology; D012083:Renin / Q000097:blood / Q000378:metabolism*; D012964:Sodium / Q000652:urine; D013599:Systole / Q000187:drug effects
chemical_list: D011941:Receptors, Adrenergic; D010656:Phenylephrine; D012964:Sodium; D012083:Renin; D004837:Epinephrine