title: An adult case of acute biphenotypic leukemia with characteristic mixed morphology.
abstract: A case of acute biphenotypic leukemia with mixed blast morphology and combined myeloid and T-lymphoid features is reported. The leukemic cells consisted of small lymphoid hand-mirror blasts and large blasts with cytoplasmic granules and rare Auer rods. The cells expressed myeloid and immature T-lymphoid features by cytochemistry and immunophenotyping, however T cell receptor genes were in germline configuration. Cases of biphenotypic leukemia with similar morphological and immunophenotypic findings have been described previously in children. This case represents a morphologically and phenotypically distinct subtype of acute biphenotypic leukemia.
authors.affiliation: Saint Luke's Hospital, Kansas City, Missouri 64111.
authors.forename: M L
authors.initials: ML
authors.lastname: Zucker
authors.forename: F V
authors.initials: FV
authors.lastname: Plapp
authors.forename: J M
authors.initials: JM
authors.lastname: Rachel
authors.forename: C A
authors.initials: CA
authors.lastname: Murphy
authors.forename: B A
authors.initials: BA
authors.lastname: Bohn
authors.forename: J L
authors.initials: JL
authors.lastname: Boeschen
authors.forename: L M
authors.initials: LM
authors.lastname: McCann
authors.forename: J T
authors.initials: JT
authors.lastname: Peterson
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D016130:Immunophenotyping; D015456:Leukemia, Biphenotypic, Acute / Q000188:drug therapy / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male