Delaminomycins, novel extracellular matrix receptor antagonists. V. Biosynthesis.
The biosynthesis of delaminomycin A, produced by Streptomyces albulus MJ202-72F3, was investigated by feeding 13C-labeled compounds followed by 13C NMR analyses. The results indicate that delaminomycin A is derived from six acetate units, five propionate units and one glycine unit.
Ueno
M
M
Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
Yoshinaga
I
I
Amemiya
M
M
Someno
T
T
Iinuma
H
H
Ishizuaka
M
M
Takeuchi
T
T
D002247:Carbon Isotopes; D002855:Chromatography, Thin Layer; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D013302:Streptomyces / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
D002247:Carbon Isotopes; D011760:Pyrrolidinones; D011956:Receptors, Cell Surface; D013764:Tetrahydronaphthalenes; C052131:extracellular matrix receptor; C082438:delaminomycin A