Partial amelioration of AZT-induced macrocytic anemia in the mouse by folic acid.
CBA/Ca mice being maintained on azidothymidine (AZT) in drinking water were given vitamin B12 and folate in an effort to ameliorate the macrocytic anemia associated with AZT administration. The B12/folate regimen was ineffectual, but higher doses of folate given daily resulted in an increase in RBC and a decrease in mean corpuscular hemoglobin (MCH) and polychromatophilic erythrocytes (PCE) while mean corpuscular volume (MCV) remained relatively constant. The implications of these findings on RBC production and hemoglobin synthesis are discussed.
Cronkite
E
E
Medical Department, Brookhaven National Laboratory, Upton, NY 11973.
Bullis
J
J
Honikel
L
L
D000748:Anemia, Macrocytic / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D005492:Folic Acid / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015215:Zidovudine
D015215:Zidovudine; D005492:Folic Acid