[Immunohistochemical study of lung tissues from patients with idiopathic pulmonary fibrosis].
Immunohistochemical analysis using 24 different monoclonal and polyclonal antibodies was applied to lung biopsy and autopsy material from 9 patients with idiopathic pulmonary fibrosis (IPF) and 6 patients without lung disorders as control. Lymphoid, non-lymphoid cells and their subsets as well as extracellular matrix (fibronectin, laminin and collagens type I, III and IV) were observed in lung interstitium. Our results suggest that local B and T lymphoid immune responses are occurring in IPF. Extracellular matrix alterations are closely linked with the local immune responses.
Hou
J
J
Nanjing Gu Drum Towerlou Hospital.
Dai
L J
LJ
Zhu
H W
HW
D016516:CD4-CD8 Ratio; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000378:metabolism; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology
D005353:Fibronectins; D007797:Laminin; D003094:Collagen