Sequence of the PAS8 gene, the product of which is essential for biogenesis of peroxisomes in Saccharomyces cerevisiae.
In a genetic screen for mutants disturbed in peroxisomal functions we found that the laboratory 'wild type' strain YP102 behaved like a typical peroxisome assembly mutant. Here, we report the sequence of the complementing gene (PAS8), coding for a protein of 1030 amino acids that appears to be a novel member of the AAA-protein family which also includes NSFp and PAS1p.
Voorn-Brouwer
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Department of Biochemistry, E.C. Slater Institute, University of Amsterdam, The Netherlands.
van der Leij
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Hemrika
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Distel
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Tabak
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D000595:Amino Acid Sequence; D001483:Base Sequence; D004271:DNA, Fungal / Q000737:chemistry; D005656:Fungal Proteins / Q000235:genetics* / Q000502:physiology; D005800:Genes, Fungal; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D008830:Microbodies / Q000502:physiology; D008969:Molecular Sequence Data; D000074435:Peroxisome-Targeting Signal 1 Receptor; D010641:Phenotype; D018160:Receptors, Cytoplasmic and Nuclear; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000648:ultrastructure
D004271:DNA, Fungal; D005656:Fungal Proteins; D008565:Membrane Proteins; D000074435:Peroxisome-Targeting Signal 1 Receptor; D018160:Receptors, Cytoplasmic and Nuclear