title: Comprehensive delineation of antigenic and immunogenic properties of peptides derived from the nef HIV-1 regulatory protein.
abstract: The Human Immunodeficiency Virus (HIV-1) nef regulatory protein, a protein involved in AIDS pathology, was used as a model to investigate and analyze B- and T-cell epitopes. In this paper, we describe the potential structural basis of antigenic and immunogenic reactivity of synthetic peptides derived from the macromolecular antigen. The relationship between B- and T-cell determinants in the context of regulatory mechanisms involved in immune recognition, while integrating recent data concerning MHC presentation. As a result of the recent progress in the field of peptide recognition and presentation, the potential of the peptide approach for constructing successful synthetic vaccines needs to be continuously re-evaluated.
authors.affiliation: Centre d'Immunologie des Maladies Transmissibles et Allergiques, Unité mixte Inserm U 167-CNRS 624, Institut Pasteur, Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Estaquier
authors.forename: C
authors.initials: C
authors.lastname: Boutillon
authors.forename: H
authors.initials: H
authors.lastname: Gras-Masse
authors.forename: J C
authors.initials: JC
authors.lastname: Ameisen
authors.forename: A
authors.initials: A
authors.lastname: Capron
authors.forename: A
authors.initials: A
authors.lastname: Tartar
authors.forename: C
authors.initials: C
authors.lastname: Auriault
mesh_terms: D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000276:immunology*; D015693:Gene Products, nef / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology*; D054311:nef Gene Products, Human Immunodeficiency Virus
chemical_list: D000956:Antigens, Viral; D015693:Gene Products, nef; D010446:Peptide Fragments; D054311:nef Gene Products, Human Immunodeficiency Virus