Effect of cyclosporin A on renal cortical resistances measured by color Doppler flowmetry on renal grafts.
Doppler spectra were recorded at different cyclosporin A (CSA) levels (trough and peak) in 30 stable renal-transplanted outpatients: 15 with unimpaired renal function (plasma creatinine < 150 mumol/l) and 15 with renal impairment (plasma creatinine 150-350 mumol/l). Pulsatility (PI) and resistive indexes (RI) have been measured in the renal artery at the hilum and in the renal cortex. RI and PI were markedly increased (p < 0.0001) in the cortex at peak time while in the renal artery no significant changes were observed. These variations were statistically related with CSA blood levels (PI = p < 0.02; r = 0.54, RI = p < 0.05; r = 0.45). These effects were also found in the presence of renal damage. CSA dose-dependently reduces cortical blood flow, causing a persistent arteriolar vasoconstriction and a reduction in diastolic flow. This effect can be measured in man in a noninvasive and repeatable way using color Doppler sonograms.
Di Palo
F Q
FQ
Clinica Medica Ia, Università di Milano, Italia.
Rivolta
R
R
Elli
A
A
Castagnone
D
D
Palazzi
P
P
Abelli
P
P
Zafiropulu
S
S
Zanussi
C
C
D000328:Adult; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology; D007672:Kidney Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D016030:Kidney Transplantation; D008297:Male; D014463:Ultrasonography; D014655:Vascular Resistance / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects
D016572:Cyclosporine; D003404:Creatinine