[Aluminum in renal osteodystrophy].
To evaluate the relationship between aluminum and renal osteodystrophy, iliac bone biopsies and bone aluminum staining were studied in 51 patients with end-stage renal failure. In 27 of 51 cases were measured PTH, 1.25 (OH)2D3 levels and bone aluminum contents. We found that the incidence of renal osteodystrophy was 100%. The positive rate of bone aluminum staining was 12%. The rate was highest in low-turnover osteomalacia. Serum aluminum and bone aluminum contents were significantly higher than controls in three types of renal osteodystrophy on hemodialysis. Bone aluminum correlated with the duration of hemodialysis (r = 0.704), also with the serum calcium (r = 0.341). The duration of hemodialysis and bone aluminum contents were markedly longer and higher in positive group of bone aluminum staining than that of negative group (P < 0.001, respectively). Our data suggested that: (1) aluminum accumulation in bone was related to duration of hemodialysis, (2) aluminum may play important roles in the intervention of bone mineralization.
Zhu
P
P
Department of Nephrology, Rui Jin Hospital, Shanghai 2nd Medical University.
Wang
G Y
GY
Yu
Y F
YF
Zhu
P
P
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000378:metabolism*; D002113:Calcification, Physiologic; D002118:Calcium / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007085:Ilium / Q000378:metabolism / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D000535:Aluminum; D002118:Calcium