title: A randomized comparison of 15- and 40-minute dosing protocols for labor augmentation and induction.
abstract: OBJECTIVE
  To compare two low-dose oxytocin protocols in terms of fetal distress, uterine hyperstimulation, cesarean delivery rate, maximum dose of oxytocin, and length of labor.
  
  
  METHODS
  We randomized 865 patients into 15-minute (incremental dose 1 mU/minute until 5 mU/minute, then 1 or 2 mU/minute) or 40-minute (incremental dose 1.5 mU/minute until 7 mU/minute, then 1.5 or 3.0 mU/minute) low-dose protocols. Before oxytocin use, all subjects were stratified according to parity and purpose of oxytocin, ie, for induction or augmentation of labor.
  
  
  RESULTS
  The 40-minute dosing protocol had a significantly lower maximum dose of oxytocin (augmentation, 6.5 versus 8.2 mU/minute, P < .001; induction, 11.5 versus 14.5 mU/minute, P < .001), a lower incidence of uterine hyperstimulation (augmentation, 18.8 versus 31.8%, P < .001; induction, 19.1 versus 33.0%, P < .002), and less fetal distress (augmentation, 15.5 versus 26.1%, P < .005). No significant differences were found in the cesarean rate or length of labor.
  
  
  CONCLUSIONS
  A dosing interval of 40 minutes led to lower incidences of uterine hyperstimulation and fetal distress, and decreased the maximum dose of oxytocin, without affecting the length of labor or the cesarean rate.
authors.affiliation: Department of Obstetrics and Gynecology, University of Connecticut, Hartford Hospital.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Lazor
authors.forename: E H
authors.initials: EH
authors.lastname: Philipson
authors.forename: C J
authors.initials: CJ
authors.lastname: Ingardia
authors.forename: E S
authors.initials: ES
authors.lastname: Kobetitsch
authors.forename: S L
authors.initials: SL
authors.lastname: Curry
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007751:Labor, Induced; D010121:Oxytocin / Q000008:administration & dosage*; D011247:Pregnancy; D013997:Time Factors
chemical_list: D010121:Oxytocin