title: Localization of the cellular expression pattern of cdc25NEF and ras in the juvenile rat brain.
abstract: In this report, we demonstrate that the brain-specific ras nucleotide-exchange factor, cdc25NEF-B, is expressed in specific neuronal populations in the juvenile rat brain. Because cdc25NEF-B likely regulates one or more of the vertebrate ras proteins, H-, K- and N-ras, we also examined their levels of expression and pattern of expression in the juvenile rat brain. We find cdc25NEF-B to be highly expressed in the hippocampus, some deep nuclei, neocortex, and the granule cell layer of the anterior lobules of the cerebellum. Our observations suggest a functional link between cdc25NEF-B and H-ras in a neuronal signal transduction pathway.
authors.affiliation: Department of Biochemistry and Molecular Biology, Kenneth Norris Jr. Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: W
authors.initials: W
authors.lastname: Wei
authors.forename: S S
authors.initials: SS
authors.lastname: Schreiber
authors.forename: M
authors.initials: M
authors.lastname: Baudry
authors.forename: G
authors.initials: G
authors.lastname: Tocco
authors.forename: D
authors.initials: D
authors.lastname: Broek
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D015870:Gene Expression; D011905:Genes, ras; D006624:Hippocampus / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009857:Oncogenes; D009928:Organ Specificity; D011712:Pyramidal Tracts / Q000378:metabolism; D015347:RNA Probes; D051381:Rats; D017207:Rats, Sprague-Dawley; D013462:Sulfur Radioisotopes
chemical_list: D009419:Nerve Tissue Proteins; D015347:RNA Probes; D013462:Sulfur Radioisotopes