An investigation of the effect of amtizol on the plastic properties of the membrane of the Retzius neuron of the leech.
The effect of amtizol, a blocker of the inactivation of calcium-dependent potassium channels of the outward current, on the spontaneous and evoked impulse activity of these cells was investigated in experiments on Retzius neurons of the leech. It was demonstrated that the extracellular application of amtizol induces a decrease in the amplitude and an increase in the duration of evoked AP, while not exerting a perceptible influence on the form of the spontaneous AP. In addition, disruption of the development of the process of habituation that develops in the norm during high-frequency synaptic activation of the neuron is observed in a solution containing amtizol.
Sergeeva
S S
SS
I. P. Pavlov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects; D004558:Electric Stimulation; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D066298:In Vitro Techniques; D007865:Leeches / Q000502:physiology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009473:Neuronal Plasticity / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D015221:Potassium Channels / Q000187:drug effects; D013830:Thiadiazoles / Q000494:pharmacology*
D009292:Narcotic Antagonists; D015221:Potassium Channels; D013830:Thiadiazoles; C044365:amtizol; D002118:Calcium