[Neurotransplantation Part II. Autografts of adrenal medulla in Parkinson's disease].
The paper reports the results of adrenal medulla autotransplantations into the brain of parkinsonian patients performed up to now in many neurosurgical centers in the world. Different surgical techniques and methods of tissue preparation for transplantation are also reviewed. Core Assessment Program for Intracerebral Transplantation (CAPIT) is presented. This program was developed as an unified system for patients' diagnosis and evaluation of clinical signs and symptoms before and after transplantation. It enables direct comparison of the results obtained in different centers. Surgical risk depending on the method of operation is discussed. The mechanisms involved in functioning of adrenal medulla grafts are considered as well as the trials to improve graft survival and its activity in the host brain. The results of neuropathological studies from autopsy cases are also reported. The analysis of about 400 published cases shows moderate or marked clinical improvement due to adrenal medulla autotransplantation which was observed until 20 months postoperatively. The results indicate that the progress of Parkinson's disease becomes slower and the clinical symptoms are less severe. L-dopa doses might be decreased which is followed by the reduction of its side effects. The opinions from different neurosurgical centers evaluating adrenal medulla autografts vary depending on the results noticed after those neurotransplantations.
Dymecki
J
J
Zakładu Neuropatologii Instytutu Psychiatrii i Neurologii, Warszawie.
D000313:Adrenal Medulla / Q000637:transplantation*; D002421:Caudate Nucleus / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008866:Microsurgery; D010300:Parkinson Disease / Q000601:surgery*; D011699:Putamen / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
Neurotransplantacje Cz. II. Autoprzeszczepy istoty rdzennej nadnerczy w chorobie Parkinsona.