The coordinated regulation of heparan sulfate, syndecans and cell behavior.
Recent advances in our understanding of heparan sulfate proteoglycans at the cell periphery implicate them as important participants in cell surface signaling. Regulation of the expression of discrete core proteins and of the specificity inherent in their heparan sulfate chains is thus emerging as a critical means of controlling cell behavior.
Rapraeger
A C
AC
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53706.
D000818:Animals; D002240:Carbohydrate Sequence; D002462:Cell Membrane / Q000502:physiology; D002468:Cell Physiological Phenomena; D005786:Gene Expression Regulation; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D011509:Proteoglycans / Q000096:biosynthesis / Q000502:physiology*; D015398:Signal Transduction; D053667:Syndecans
D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053667:Syndecans