Tyramine conjugation deficit in patients with chronic idiopathic temporomandibular joint and orofacial pain.
This study was carried out to explore the value of the tyramine conjugation test, an established trait marker for 'endogenous unipolar depression', in patients with chronic idiopathic temporomandibular joint and orofacial pain. Our results show that the pain patients excrete significantly lower amounts of tyramine sulphate than controls (P < 0.0004). Psychiatric assessment by the structured clinical interview for the diagnosis of mental disorders according to DSM-III-R revealed that 48% of the patients had a history of depression and 10% were currently depressed. However, the never-depressed group of patients had the lowest tyramine sulphate excretion values. These findings suggest that a common biological abnormality underlies the pathogenesis of both chronic idiopathic facial pain and depression.
Aghabeigi
Benham
B
Joint Department of Maxillofacial Surgery and Oral Medicine, Eastman Dental and University College Hospitals, London WC1X 8LD UK Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London W6 OXG UK.
Feinmann
Charlotte
C
Glover
Vivette
V
Goodwin
Brian
B
Hannah
Pat
P
Harris
Malcolm
M
Sandler
Merton
M
Wasil
Mohammad
M
D000328:Adult; D000367:Age Factors; D002908:Chronic Disease; D003866:Depressive Disorder / Q000150:complications; D005157:Facial Pain / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000150:complications / Q000378:metabolism*; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000150:complications / Q000378:metabolism*; D014439:Tyramine / Q000378:metabolism* / Q000652:urine
D014439:Tyramine