title: Eltanolone for induction of anaesthesia and to supplement nitrous oxide for minor gynaecological surgery.
abstract: We have used eltanolone to induce anaesthesia and by intermittent injection to supplement nitrous oxide during maintenance in 50 patients undergoing minor gynaecological surgery; opioids were not used. Induction of anaesthesia was remarkably trouble free and achieved with a single dose of 0.5 mg.kg-1 in 90% of patients. Pain on injection was not a feature. Satisfactory anaesthesia was achieved in 84% of patients; eight required addition of isoflurane. There were minimal cardiovascular changes and apnoea on induction occurred in only one patient. Recovery times were acceptable.
authors.affiliation: Department of Anaesthesia, Royal Postgraduate Medical School, Hammersmith Hospital, London.
authors.forename: A
authors.initials: A
authors.lastname: Rajah
authors.forename: H
authors.initials: H
authors.lastname: Powell
authors.forename: M
authors.initials: M
authors.lastname: Morgan
mesh_terms: D000032:Abortion, Therapeutic; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D004107:Dilatation and Curettage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D013511:Minor Surgical Procedures; D009609:Nitrous Oxide; D011247:Pregnancy; D011280:Pregnanolone; D013997:Time Factors
chemical_list: D011280:Pregnanolone; D009609:Nitrous Oxide