title: [Increased incidence of Crohn disease in the county of Copenhagen].
abstract: The incidence of Crohn's disease was assessed in a population based study in Copenhagen County from 1962-1987. The incidence increased six fold during the study period from 0.62/10(5) in 1962 to a mean of 4.1/10(5) from 1979-1987, equally in both sexes. The highest incidence was found in the age group 15-24 years: 12.8/10(5) for women and 6.0/10(5) for men (as mean of the period 1979-1987). The prevalence at the end of the study was 54/10(5). The clinical symptoms and extent of disease at diagnosis did not change over the time, but a significantly higher disease activity was found in the 1980's, 74% (1962-1979) vs 84% (1980-1987), p = 0.04. The increase in incidence of Crohn's disease is well established in most parts of the industrialized world. The analysis shows that it is not due to a new disease entity, since the extent of disease, the age and sex distribution, and the symptoms remained unchanged during the 26 year study period.
authors.affiliation: Medicinsk gastroenterologisk afdeling C, Københavns Amts Sygehus i Herlev.
authors.forename: P
authors.initials: P
authors.lastname: Munkholm
authors.forename: E
authors.initials: E
authors.lastname: Langholz
authors.forename: O H
authors.initials: OH
authors.lastname: Nielsen
authors.forename: S
authors.initials: S
authors.lastname: Kreiner
authors.forename: V
authors.initials: V
authors.lastname: Binder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012042:Registries
vernacular_title: Stigende incidens af morbus Crohn i Københavns Amt.