title: Distribution of wild type 1 poliovirus genotypes in China.
abstract: Poliomyelitis remains an important public health problem in China. Most cases and outbreaks are associated with wild type 1 polioviruses. To obtain an overview of type 1 poliovirus transmission in China, partial genomic sequences were compared for 24 case isolates from 12 provinces. Because polioviruses evolve rapidly during infection of humans, the genetic relationships among isolates provide a measure of the extent of epidemiologic linkage among cases. The observed genetic relationships were complex: six different genotypes, apparently derived from five separate endemic origins, were found. One genotype was recombinant, having noncapsid sequences derived from the Sabin type 1 vaccine strain and capsid sequences derived from a genotype indigenous to several northern and eastern provinces. Some isolates from geographically separate provinces were closely related; other isolates were related to wild polioviruses found in neighboring countries. The combination of epidemiologic and virologic analyses may facilitate the development of more effective strategies for poliomyelitis eradication.
authors.affiliation: Jiangxi Provincial Anti-Epidemic Station, Nanchang, China.
authors.forename: D P
authors.initials: DP
authors.lastname: Zheng
authors.forename: L B
authors.initials: LB
authors.lastname: Zhang
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Fang
authors.forename: C F
authors.initials: CF
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Mulders
authors.forename: M A
authors.initials: MA
authors.lastname: Pallansch
authors.forename: O M
authors.initials: OM
authors.lastname: Kew
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D002681:China / Q000453:epidemiology; D004279:DNA, Viral; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D011051:Poliomyelitis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D017955:Poliovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral