Human and baboon integrin beta 5 subunit-encoding mRNAs have alternative polyadenylation sites.
A cDNA probe, encoding part of the human integrin polypeptide, GPIIIa (beta 3), was used to screen a cDNA library derived from baboon smooth muscle polyadenylated mRNA. One cross-hybridizing clone, lacking the baboon equivalent of 478 bp of the human sequence, was found to be 98% similar to a human cDNA encoding the beta 5-chain of the receptor for vitronectin, a cell adhesion molecule. The baboon mRNA terminates at 3' position 212 nucleotides upstream from the polyadenylation site of the aligned human mRNA.
Shoji
M
M
Division of Hematology-Oncology, Emory University School of Medicine, Atlanta, GA 30322.
Hayzer
D J
DJ
Kim
T M
TM
Runge
M S
MS
Hanson
S R
SR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D039641:Integrin beta Chains; D016023:Integrins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D010215:Papio / Q000235:genetics*; D011061:Poly A / Q000378:metabolism; D016415:Sequence Alignment
D039641:Integrin beta Chains; D016023:Integrins; C084344:integrin beta5; D011061:Poly A; D004247:DNA