title: Longevity is moderately heritable in a sample of Danish twins born 1870-1880.
abstract: The heritability of human longevity was investigated in a sample of 218 pairs of monozygotic (MZ) and 382 pairs of like-sex dizygotic (DZ) Danish twin pairs born 1870-1880. Twin similarity for age at death was significant for MZ twins but nonsignificant for DZ twins. The heritability (h2) of life span estimated from the best-fitting biometrical model was statistically significant but moderate in magnitude (h2 = .333 +/- .058). Heritability of longevity did not vary by gender, and the pattern of twin resemblance was more consistent with nonadditive as compared to additive genetic effects. In addition, evidence for a genetic association between premature and senescent deaths was observed. Although environmental factors accounted for a majority of the variance in life span, the relevant environmental factors appeared to be those that create differences rather than similarities among reared-together relatives. Findings are discussed in terms of their relevance for understanding the inheritance and evolution of human life span.
authors.affiliation: Department of Psychology, University of Minnesota, Minneapolis 55455.
authors.forename: M
authors.initials: M
authors.lastname: McGue
authors.forename: J W
authors.initials: JW
authors.lastname: Vaupel
authors.forename: N
authors.initials: N
authors.lastname: Holm
authors.forename: B
authors.initials: B
authors.lastname: Harvald
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000235:genetics*; D008297:Male; D012959:Socioeconomic Factors; D014427:Twins / Q000235:genetics*