title: [Emergency cardiopulmonary bypass (ECPB) for cardiopulmonary-cerebral resuscitation; (2). Physiologic changes].
abstract: After normothermic ventricular fibrillation (Vf) cardiac arrest of 15 min, 15 female mongrel dogs received conventional cardiopulmonary resuscitation (CPR) for 3 min and then cardiopulmonary bypass through the femoral artery and veins (F-F bypass). Cardiac beat did not return in any dogs during the initial 3-min CPR. Spontaneous circulation was restored by defibrillation 5.2 +/- 3.8 (mean +/- SD) min after the initiation of the F-F bypass in all dogs except in one with bypass trouble. Life-threatening ventricular dysrhythmias appeared in 8 of the 14 dogs (57%). Eleven of the 14 dogs (79%) were successfully weaned from the F-F bypass. Spontaneous respiration and circulation remained stable for the subsequent 1-h observation period in 8 dog (57%). The values of cardiac output measured just before weaning from the bypass and 30 to 60 min after weaning were significantly lower than those before inducing Vf (n = 5). On the electroencephalogram, intermittent burst waves reappeared 90.0 +/- 24.7 min after the initiation of resuscitation and EEG showed continuous waves 130.7 +/- 28.1 min (n = 7) after the initiation of resuscitation. The values of blood glucose, lactate and potassium 5 to 15 min after the initiation of F-F bypass were significantly higher than those before induction of Vf, while the values of hemoglobin, hematocrit, platelet and serum protein decreased significantly (n = 14).
authors.affiliation: Department of Anesthesia, National Medical Center, Tokyo.
authors.forename: A
authors.initials: A
authors.lastname: Hashiguchi
authors.forename: T
authors.initials: T
authors.lastname: Kano
authors.forename: M
authors.initials: M
authors.lastname: Sadanaga
authors.forename: K
authors.initials: K
authors.lastname: Ashimura
authors.forename: T
authors.initials: T
authors.lastname: Morioka
mesh_terms: D000818:Animals; D001831:Body Temperature; D002302:Cardiac Output; D002315:Cardiopulmonary Bypass / Q000379:methods*; D016887:Cardiopulmonary Resuscitation; D004285:Dogs; D004569:Electroencephalography; D004630:Emergencies; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism
chemical_list: D006454:Hemoglobins