Are pill counts valid measures of compliance in clinical obstetric trials?
We compared pill counts with a biochemical measure of compliance in 283 women who participated in a randomized double-blind trial that evaluated the efficacy of low-dose aspirin in the prevention of preeclampsia. Subjects whose pill counts indicated a usage > 100% were less compliant than women with lower pill counts.
DuBard
M B
MB
Department of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333.
Goldenberg
R L
RL
Copper
R L
RL
Hauth
J C
JC
D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010349:Patient Compliance; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D013929:Thromboxane B2 / Q000097:blood
D013929:Thromboxane B2; D001241:Aspirin