Cyclosporin-A-induced gingival overgrowth in renal transplant children.
Gingival overgrowth was assessed in renal transplant children, 19 boys and 13 girls, aged 2.5-18 yr, who had been on a cyclosporin-A (CsA)-based immunosuppressive regimen for at least 12 months. Data collected included number of posttransplant months, total CsA dose administered during the first 6 posttransplant months, oral dose and blood trough level of CsA on the day of examination, plaque accumulation (VPI%), gingival inflammation (GBI%), loss of attachment, and gingival overgrowth. Thirteen percent of the children exhibited gingival overgrowth characterized by one or more units with increased sulcus probing depth (> or = 4 mm), i.e. pseudopockets. The total amount of CsA administered during the first 6 posttransplant months was significantly higher in the children with gingival overgrowth than in those without. The study indicates that the development of CsA-induced gingival overgrowth is positively related to the total dose of the drug administered to the children during the first 6 posttransplant months.
Wondimu
B
B
Department of Pedodontics, Faculty of Odontology, Huddinge University Hospital, Karolinska Institutet, Sweden.
Dahllöf
G
G
Berg
U
U
Modéer
T
T
D000284:Administration, Oral; D000293:Adolescent; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D003773:Dental Plaque / Q000150:complications; D003774:Dental Plaque Index; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005886:Gingival Hypertrophy / Q000139:chemically induced*; D005891:Gingivitis / Q000150:complications; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009910:Oral Hygiene; D010512:Periodontal Index; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
D004338:Drug Combinations; D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine