The platelet angiotensin II receptor in type I diabetes: studies in patients with and without nephropathy.
Experimental studies demonstrate impaired regulation of the mesangial angiotensin II (AII) receptor in diabetes. This could contribute to the disturbance of glomerular blood flow and the development of diabetic nephropathy. The aim of this study was to determine whether a similar receptor abnormality occurs in patients with type I insulin-dependent diabetes mellitus (IDDM) and if so whether this is more prevalent in patients with micro- or macro-albuminuria. The platelet AII receptor was chosen because of its availability from the circulation and its comparable regulatory properties to tissue-based receptors. The interaction between plasma AII and its platelet receptor was examined in 45 patients with IDDM and 36 age- and sex-matched control subjects. Seven patients had clinical nephropathy and two had persistent micro-albuminuria. The duration of diabetes varied from 1 month to 42 years. There was a significant inverse correlation between plasma AII and the logarithm of receptor number in the control group (r = -0.555, P < 0.001). This relationship was not observed in the diabetic patients irrespective of the duration of disease or the presence of nephropathy. Receptor expression in patients without nephropathy showed no correlation with either duration of disease or the degree of glycaemic control. However, a significant relationship between AII receptor number and duration of diabetes was noted in the group with nephropathy (r = 0.723, P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Makarious
M
M
Department of Medicine, Prince Henry Hospital, Sydney, Australia.
Pawlak
M
M
Campbell
L V
LV
Timmermans
V
V
Duggan
K
K
Charlesworth
J A
JA
Macdonald
G J
GJ
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D011945:Receptors, Angiotensin / Q000032:analysis*; D013997:Time Factors
D011945:Receptors, Angiotensin