title: Two computer programs using logit transformation for the analysis of S-shaped curves.
abstract: Two BASIC computer programs using logit transformation for the analysis of S-shaped curves are presented. The first program estimates the median effective dose (ED50) of drugs. A maximum likelihood method similar to Finney's algorithm of probit analysis is applied. The second fits S-shaped curves to empirical data which cannot be transformed easily to proportions. Logit transformation proves to be a simple and accurate alternative to probit transformation when computing memory is limited or calculation speed is critical.
authors.affiliation: Department of Dermatology, University of Graz, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Rieger
authors.forename: J J
authors.initials: JJ
authors.lastname: Bijl
authors.forename: M
authors.initials: M
authors.lastname: Rieger
mesh_terms: D000465:Algorithms; D003199:Computer Systems; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D016015:Logistic Models; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D012984:Software; D012985:Software Design
chemical_list: D004364:Pharmaceutical Preparations