title: Efficacy of doramectin against warble fly larvae (Hypoderma bovis).
abstract: The efficacy of doramectin in the treatment of cattle harbouring naturally acquired infestations of first, second and third instar larvae of Hypoderma bovis was determined in two studies carried out in the Burgundy region of France. In the first study, cattle on six farms with a history of H. bovis infestations were treated during October 1989 with either doramectin at a dose of 200 micrograms kg-1 liveweight (186 animals) or with an equivalent volume of saline (157 animals). During the following March and April, all animals were examined for the presence of warbles. In the second study, cattle on four farms with warbles present in their backs were treated during March 1990, with either doramectin or saline (as before). The viability of larvae within each warble on all the animals was then assessed every 2 days for 14 days. In Study 1, no warbles were present in any of the doramectin-treated cattle at any time, whereas warbles were found in 135 saline-treated animals. In Study 2, all larvae in warbles on the backs of the doramectin-treated cattle were dead by Day 14 after treatment, whereas viable larvae were still present in warbles in the backs of all saline-treated cattle. No adverse reaction to doramectin treatment was observed in any animal at any time. It was concluded that doramectin is both safe and 100% efficacious in the treatment of first, second and third instar H. bovis infections of cattle.
authors.affiliation: Pfizer Central Research, Sandwich, UK.
authors.forename: M O
authors.initials: MO
authors.lastname: Hendrickx
authors.forename: L
authors.initials: L
authors.lastname: Anderson
authors.forename: C
authors.initials: C
authors.lastname: Boulard
authors.forename: D G
authors.initials: DG
authors.lastname: Smith
authors.forename: A J
authors.initials: AJ
authors.lastname: Weatherley
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000276:immunology; D004175:Diptera / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005602:France; D007000:Hypodermyiasis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007814:Larva / Q000276:immunology; D008297:Male
chemical_list: D000909:Antibodies, Helminth; D007306:Insecticides; D007559:Ivermectin; C084101:doramectin