[Effect of dihydroepiandrosterone sulfate on the tension of uterine cervix and its mechanisms].
After i.v. injection of dihydroepiandrosterone sulfate (DHA-S) at 20 or 40 mg/kg to female rats on day 19 of gestation, the tension and hydroxyproline level of uterine cervix were decreased obviously. However, DHA-S at 10 mg/kg showed no effect on the tension of uterine cervix. DHA-S in vitro, at 0.1 mg/kg significantly increased estradiol secretion in the ovaries and placenta of late pregnant rats.
Zuo
X C
XC
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Qiao
F X
FX
Wang
N G
NG
Zhou
L F
LF
Guan
M Z
MZ
D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects* / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D066298:In Vitro Techniques; D010053:Ovary / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D003687:Dehydroepiandrosterone; D004958:Estradiol; D006909:Hydroxyproline