Parvalbumin-immunoreactive dystrophic neurites and aberrant sprouts in the cerebral cortex of patients with Alzheimer's disease.
Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lobe was carried out for diagnostic and counselling purposes. These findings suggest that, although parvalbumin-immunoreactive cells are relatively resistant to degeneration in Alzheimer's disease, parvalbumin-immunoreactive neuronal processes can degenerate in some cases of Alzheimer's disease.
Ferrer
I
I
Unidad de Neuropatología, Hospital Príncipes de España, Universidad de Barcelona, Hospitalet de Llobregat.
Zújar
M J
MJ
Rivera
R
R
Soria
M
M
Vidal
A
A
Casas
R
R
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D016501:Neurites / Q000648:ultrastructure*; D010320:Parvalbumins / Q000276:immunology / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D010320:Parvalbumins; D005680:gamma-Aminobutyric Acid