Involvement of catecholamines in the effect of U-50,488H on isolated left atria of the rat.
1. The present study examined the effect of U-50,488H on auricular contraction of isolated left atria of the rat. 2. The negative inotropic action induced by the kappa-agonist was antagonized in the presence of propranolol (10(-8) or 5 x 10(-8) M), yohimbine (5 x 10(-7) or 10(-6) M) or in reserpinized rats (5 mg/kg i.p. 24 hr before the experiments). 3. These results suggest that catecholaminergic mechanisms are involved in the cardiac depressant effect induced by U-50,488H.
Micol
J A
JA
Department of Anesthesiology, CSV Arrixaca Hospital, Murcia, Spain.
Laorden
M L
ML
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002395:Catecholamines / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D011759:Pyrrolidines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000187:drug effects / Q000502:physiology; D012110:Reserpine / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D002395:Catecholamines; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; D015016:Yohimbine; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D012110:Reserpine; D011433:Propranolol