Malaria transmission-blocking activity in the plasma of Plasmodium falciparum gametocyte carriers in Cameroon.
Experimental infections of Anopheles gambiae were carried out with Plasmodium falciparum gametocytes from 65 naturally infected patients in Cameroon. A comparison was made between infections with blood containing autologous plasma and blood in which the plasma was replaced by plasma from donors without previous malaria exposure. A lower mosquito-infection rate was observed in 50 out of 65 autologous plasma samples. The transmission was completely blocked in 8 infections, whilst belonging exposures to heterologous plasma led to infected mosquitoes. Evidence is shown that blood plasma factors of gametocyte carriers from a population living in a malaria-endemic area are able to reduce transmission capacity.
Mulder
B
B
University of Nijmegen, Department of Medical Parasitology, The Netherlands.
Tchuinkam
T
T
Verhave
J P
JP
Robert
V
V
D000293:Adolescent; D000328:Adult; D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D002163:Cameroon; D002353:Carrier State / Q000097:blood* / Q000469:parasitology; D002648:Child; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000097:blood* / Q000469:parasitology / Q000635:transmission; D010963:Plasmodium falciparum / Q000254:growth & development / Q000302:isolation & purification*; D012098:Reproduction