title: Nonlinear identification of the PCO2 control system in man.
abstract: Two approaches to identification of the PCO2 system in man are described. The first uses a nonlinear 'black box' NARMAX identification package, while the second method uses a structured two-compartment Belville model. The data were obtained from volunteers breathing either room air or a controlled gas mixture, controlled via a pseudorandom M-sequence. Measurements were made of respiratory gas flow and PCO2 content of inspired and expired gases. The identification results indicate that a low-order dynamic model with nonlinear polynomial expansion gave the best fit to the data. In contrast, the Belville model gave best results with a two-compartment linear model, mainly because of difficulties in the optimisation routines when the Belville model was not linear. Thus, modern systemic methods of excitation and identification appear to be appropriate for modelling this respiratory subsystem of humans.
authors.affiliation: Division of Electronic Engineering, Tokyo Medical and Dental University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Noshiro
authors.forename: M
authors.initials: M
authors.lastname: Furuya
authors.forename: D
authors.initials: D
authors.lastname: Linkens
authors.forename: K
authors.initials: K
authors.lastname: Goode
mesh_terms: D000328:Adult; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D003198:Computer Simulation; D005069:Evaluation Studies as Topic; D005246:Feedback; D006706:Homeostasis; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008954:Models, Biological; D011659:Pulmonary Gas Exchange; D012119:Respiration; D012984:Software
chemical_list: D002245:Carbon Dioxide