title: Alstonia species: are they effective in malaria treatment?
abstract: A review of the literature on Alstonia species indicates that evidence in support of their effectiveness in the treatment of malaria is controversial. The antiprotozoal activity of the major alkaloid present in Alstonia species, echitamine, was assessed in vitro against Plasmodium falciparum and Giardia intestinalis. Echitamine displayed little antiplasmodial activity, but two quinoline alkaloids from A. coriacea (corialstonine and corialstonidine) were found to have some activity against P. falciparum although this was approximately 10 times less than that of quinine. None of the three Alstonia alkaloids was active against G. intestinalis. These results are discussed in the context of previously published data.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, London, UK.
authors.forename: C W
authors.initials: CW
authors.lastname: Wright
authors.forename: D
authors.initials: D
authors.lastname: Allen
authors.forename: J D
authors.initials: JD
authors.lastname: Phillipson
authors.forename: G C
authors.initials: GC
authors.lastname: Kirby
authors.forename: D C
authors.initials: DC
authors.lastname: Warhurst
authors.forename: G
authors.initials: G
authors.lastname: Massiot
authors.forename: L
authors.initials: L
authors.lastname: Le Men-Olivier
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D016829:Giardia lamblia / Q000187:drug effects*; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D010936:Plant Extracts; C001133:echitamine