Cerebral oxygen metabolism during hypothermic circulatory arrest in humans.
Profound hypothermia with circulatory arrest is an important surgical adjuvant that allows protected cessation of cerebral blood flow for a brief period. In seven patients undergoing this procedure, continuous spectroscopic measurement of cerebral hemoglobin oxygen saturation was performed. Circulatory arrest at 18 degrees C was associated with a significant progressive desaturation (p < 0.01) of residual cerebral hemoglobin. Arrest time varied based on operative complexity (range 10 to 65 minutes), and a negative linear correlation between arrest time (y) and oxygen saturation (x) was noted (y = -0.87 x + 64). Five patients whose saturation remained above 35% had no neurological injury attributable to hypoxia. One patient (Hunt and Hess Grade 0) whose saturation fell below 35% had evidence of a global hypoxic injury at postmortem examination. Spectroscopically measured cerebral hemoglobin saturation (cerebral oximetry) may be used to monitor metabolic activity during circulatory arrest. Although the clinical utility of such monitoring cannot be established at this time, the potential may exist to prolong the safe duration of induced circulatory arrest for cerebral protection.
Ausman
J I
JI
Department of Neurosurgery, University of Illinois, Chicago.
McCormick
P W
PW
Stewart
M
M
Lewis
G
G
Dujovny
M
M
Balakrishnan
G
G
Malik
G M
GM
Ghaly
R F
RF
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism*; D004569:Electroencephalography; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D002532:Intracranial Aneurysm / Q000601:surgery*; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D016896:Treatment Outcome
D010100:Oxygen