title: Carcinoma of the cervix: predictive value of clinical and magnetic resonance (MR) imaging assessment of prognostic factors.
abstract: OBJECTIVE
  This retrospective study assesses the predictive value of magnetic resonance imaging (MRI) to identify high risk cervical cancer patients.
  
  
  METHODS
  The MRI evaluation of morphologic risk factors in patients with invasive cervical carcinoma treated with definitive radiation therapy were correlated with clinical factors and with complete tumor regression (CTR) at 6 months, tumor local control (TLC), and patient outcome at 12 months after irradiation. Sixty-six patients, median age 44.5 years, with bulky Stage I or greater disease were included in the study.
  
  
  RESULTS
  In univariate analysis, clinical International Federation of Gynecology and Obstetrics (FIGO) stage had significant correlation with patient outcome, but it correlated poorly with complete tumor regression and tumor local control. In contrast, MRI stage showed significant correlation with complete tumor regression, tumor local control, and disease-free survival at 12 months. When each stage was analyzed separately, the greatest difference was demonstrated between clinical and MRI assignment of stage Ib disease. MRI Stage Ib disease significantly correlated with all three categories analyzed, while clinical Stage Ib did not. Superiority of MRI assessment of low stage disease was also evident in the detection of lymph node metastasis. Significant risk for nodal metastasis was related to tumor size greater than 4 cm, invasion of the parametria and urinary bladder, and stage of the disease.
  
  
  CONCLUSIONS
  The multivariate analysis demonstrated that the most related variables in order of significance were the presence of juxta-regional and paraaortic lymph nodes, patient age, tumor size, and MRI tumor stage. This study demonstrates the value of MR imaging as an adjunct to clinical assessment of bulky invasive cervical cancer, rendering more complete assessment of morphologic risk factors important in patient prognosis.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143-0628.
authors.forename: H
authors.initials: H
authors.lastname: Hricak
authors.forename: J M
authors.initials: JM
authors.lastname: Quivey
authors.forename: Z
authors.initials: Z
authors.lastname: Campos
authors.forename: V
authors.initials: V
authors.lastname: Gildengorin
authors.forename: T
authors.initials: T
authors.lastname: Hindmarsh
authors.forename: K G
authors.initials: KG
authors.lastname: Bis
authors.forename: J L
authors.initials: JL
authors.lastname: Stern
authors.forename: T L
authors.initials: TL
authors.lastname: Phillips
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000532:radiotherapy*