Is there any relationship between aluminum and Alzheimer's disease?
The controversial role of aluminum in Alzheimer's disease (AD) is reviewed. While current data would suggest the lack of a causative role, alterations in the brain and other organ systems caused by AD might increase the penetration of aluminum as well as other metals into the brain and lead to their contribution to such pathological features as neurofibrillar tangles (NFTs).
Eichhorn
G L
GL
National Institutes of Health, National Institute on Aging, Laboratory of Cellular and Molecular Biology, Baltimore, Maryland 21224.
D000368:Aged; D000535:Aluminum / Q000009:adverse effects* / Q000493:pharmacokinetics; D000544:Alzheimer Disease / Q000139:chemically induced* / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D016874:Neurofibrillary Tangles / Q000187:drug effects; D012825:Silicon / Q000633:toxicity
D000535:Aluminum; D012825:Silicon