title: Neuroendocrine and behavioral effects of vasopressin in resting and mild stress conditions.
abstract: Neuroendocrine and behavioral effects of subcutaneously administered AVP (6 micrograms/kg b.wt.) were determined in resting conditions and after the mild stress of transportation to and placement in a novel environment. In resting conditions, systemic administration of AVP caused a rapid increase in blood glucose level and a long-lasting increase in CORT secretion. A decrease in circulating plasma NE level was observed. AVP did not affect adrenal medullary E secretion. The stress-induced sympathetic activation, as reflected in plasma NE level, was inhibited 60 min after AVP administration. Stress-induced increases in blood glucose, CORT, and E secretion were not influenced by AVP. In resting condition, AVP caused a 60-min lasting increase in grooming behavior with a concomitant decrease in time spent resting. Sixty minutes after administration, the behavioral activation after the stress of transportation and placement in a novel environment was more rapidly terminated in AVP-treated rats than in vehicle-treated control rats. The state- and time-dependent modulation of spontaneous behavior suggests that AVP has arousing properties shortly after administration when marked pressor and endocrine effects are apparent. In a later phase, AVP may facilitate dearousal mechanisms following stress-induced behavioral activation.
authors.affiliation: Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Buwalda
authors.forename: C
authors.initials: C
authors.lastname: Nyakas
authors.forename: J M
authors.initials: JM
authors.lastname: Koolhaas
authors.forename: B
authors.initials: B
authors.lastname: Bohus
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood*; D004837:Epinephrine / Q000097:blood*; D006120:Grooming / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D001127:Arginine Vasopressin; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine