Pharmacological actions of "kyushin," a drug containing toad venom (3): Effects on experimentally induced arrhythmia.
The pharmacological effects of the toad venom-containing drug "kyushin" on aconitine- and thyroxine-induced arrhythmia in guinea pigs, on the conduction system in Langendorff preparations of rabbit hearts and on the autonomic nervous system in cats were studied. "kyushin" significantly inhibited the aconitine-induced arrhythmia after intraduodenal administration (i.d.) with 80 mg/kg, and the thyroxine-induced arrhythmia with 40 mg/kg i.d. Although "kyushin" itself did not affect the conduction system with 30 mg/ml of the maximal concentration being able to be prepared, bufalin and cinobufagin as constituents of toad venom produced inhibition with 0.3 mg/ml and 1 mg/ml, respectively. The decrease in heart rate induced by electrical stimulation to the parasympathetic nerve (vagus nerve) was potentiated by "kyushin" at 30 mg/kg i.d. The anti-arrhythmic effects of "kyushin" may be attributable to both possible inhibitory effect on the conduction system and potentiating effect on the parasympathetic nervous system.
Morishita
S
S
Research Laboratories, Kyushin Pharmaceutical Co., Ltd., Tokyo, Japan.
Sugimoto
C
C
Shoji
M
M
Hirai
Y
Y
Oguni
Y
Y
Ito
C
C
Higuchi
M
M
Sakanashi
M
M
D000157:Aconitine / Q000633:toxicity; D000664:Amphibian Venoms / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001341:Autonomic Nervous System / Q000187:drug effects; D002415:Cats; D004077:Digoxin / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D013974:Thyroxine / Q000633:toxicity
D000664:Amphibian Venoms; D008419:Materia Medica; D004077:Digoxin; D011433:Propranolol; D013974:Thyroxine; D000157:Aconitine