The brainstem cardioarrhythmogenic triggers and their possible role in sudden epileptic death.
The cardiovascular effects of simultaneous activation of hypothalamic and mesencephalic cardioarrhythmogenic triggers were studied in hemispherectomized rats. Paroxysmal activity of hypothalamic neurons (HEF), elicited by topical application of penicillin G on the thalamus, triggered short-lasting bradyarrhythmic episodes, up to a maximum of 6 s, and alterations in repolarization. In the hypothalamic neurons, an additional penicillin G epileptic focus at mesencephalic level (MEF) induced the enhancement of paroxysmal activity by a recruitment of new units and potentiation of their background activity. HEF+MEF triggered second-degree 2:1-8:1 atrioventricular (A-V) blocks, impairment of the A-V conduction, alterations in the recovery phase and bundle branch blocks. After HEF, the arterial blood pressure decreased by 4-6%. HEF+MEF induced a further reduction of 17% in systolic pressure only. It is possible that the enhancement of the HEF following MEF could depend on MEF spreading upward. The HEF, in turn, by spreading downward could influence the MEF and so activate, between HEF and MEF, a circuitry with reciprocal co-excitation that could explain the more serious cardiovascular alterations observed during HEF+MEF compared with those observed during HEF only or during MEF only. However, this cardiovascular impairment, which must be neurogenic in origin as it was observed in animals with normal acid-base and blood parameter values, did not induce heart death. Thus, additional concomitances must be considered, such as metabolic derangement which can occur during seizures, to explain sudden death in epileptic patients. Some aspects of metabolic complications in cardiac activity during epilepsy are also discussed.
Mameli
O
O
Institute of Human Physiology, University of Sassari, Italy.
Melis
F
F
Giraudi
D
D
Cualbu
M
M
Mameli
S
S
De Riu
P L
PL
Mameli
P
P
D000136:Acid-Base Equilibrium / Q000502:physiology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D001933:Brain Stem / Q000473:pathology / Q000503:physiopathology*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography; D004594:Electrophysiology; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D007031:Hypothalamus / Q000473:pathology / Q000503:physiopathology; D008636:Mesencephalon / Q000473:pathology / Q000503:physiopathology; D010400:Penicillin G; D051381:Rats; D017208:Rats, Wistar; D012121:Respiration, Artificial
D010400:Penicillin G