title: Clinical features, pathogenesis, and computed tomographic characteristics of internal watershed infarction.
abstract: OBJECTIVE
  Infarction in the internal border-zone region has been described radiologically and pathologically. The aim of this study was to define the clinical and pathophysiological correlates of internal watershed infarction.
  
  
  METHODS
  Eighteen consecutive stroke patients with evidence of internal watershed infarction on computed tomography (CT) were studied.
  
  
  RESULTS
  Two CT patterns were identified: 6 patients had confluent internal watershed infarction (CIWI), and 12 patients had partial internal watershed infarction (PIWI). Syncopal symptoms and/or documented hypotension were prominent in both groups. Patients with CIWI usually presented with stepwise onset of contralateral hemiplegia and recovered poorly; patients with PIWI usually had discrete episodes of brachiofacial sensorimotor deficit and good recovery. Both groups had evidence of cortical involvement as part of their clinical deficit. Severe carotid occlusive disease was seen in 10 patients, and 12 patients had evidence of transiently impaired cardiac output. Carotid disease (P < .001), cardiac disease (P < .01), and diabetes mellitus (P < .01) were more prevalent in patients with internal watershed infarction compared with our stroke population as a whole.
  
  
  CONCLUSIONS
  Distinguishing internal watershed infarction from lacunar and other subcortical infarctions is important because the different pathological mechanisms demand different therapeutic strategies.
authors.affiliation: Department of Neurology, University of Melbourne, Heidelberg Repatriation Hospital, Australia.
authors.forename: C F
authors.initials: CF
authors.lastname: Bladin
authors.forename: B R
authors.initials: BR
authors.lastname: Chambers
mesh_terms: D000208:Acute Disease; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications; D002340:Carotid Artery Diseases / Q000150:complications; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking; D014057:Tomography, X-Ray Computed