title: Probes for the study of mupirocin resistance in staphylococci.
abstract: Probes constructed from a 4.05-kb EcoRI digest fragment of a mupirocin resistance plasmid and a 751-bp internal part of this fragment hybridised with DNA from all of 36 independent high-level mupirocin-resistant staphylococci tested from seven centres; most were Staphylococcus aureus. In most instances the probes detected an EcoRI digest fragment of approximately 4 kb. Probes did not hybridise to DNA from low-level resistant strains, nor from strains sensitive to mupirocin.
authors.affiliation: Department of Microbial Diseases, St John's Institute of Dermatology, St Thomas' Hospital, London.
authors.forename: M
authors.initials: M
authors.lastname: Rahman
authors.forename: W C
authors.initials: WC
authors.lastname: Noble
authors.forename: K G
authors.initials: KG
authors.lastname: Dyke
mesh_terms: D015342:DNA Probes; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D016712:Mupirocin / Q000494:pharmacology*; D009693:Nucleic Acid Hybridization; D011815:R Factors; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000235:genetics
chemical_list: D015342:DNA Probes; D016712:Mupirocin