title: [Dynamic magnetic resonance tomography in aortic valve insufficiency: methodologic comparison with aortography and color Doppler echocardiography].
abstract: To evaluate the usefulness of cine-MRI for the quantitative assessment of aortic valve regurgitation, 31 patients (54 +/- 15 years of age; 22 M, 9 F) and 10 normal volunteers underwent a multi-modality imaging protocol comparing cine-MRI with color Doppler echocardiography and contrast aortography. Twenty-one patients had aortic regurgitation with an associated transvalvular gradient, 10 patients had pure valve incompetence. Aortic insufficiency as assessed by the signal void from regurgitant flow on cine-MRI was best analyzed on transversal tomograms. Both the volume of the signal void caused by turbulence above a threshold velocity, and the ratio of the diameters of the regurgitant jet and the outflow tract (dAL-Jet/DLVOT) were found to correlate closely with the (Seller's) angiographic regurgitant score by r = 0.86 each (p < 0.001), and the color Doppler echocardiographic index by r = 0.74 and 0.89, respectively (p < 0.001). Cine-MRI failed to differentiate the angiographic grades I and II, however, clearly separated grades II, III, and IV in contrast to other non-invasive imaging modalities. Moreover, a semiquantitative index derived from cine-MRI allowed a rapid assessment of the severity of regurgitation, similar to color Doppler echocardiography and the semiquantitative angiographic Seller's score. Thus, cine-MRI volumetric evaluation of transvalvular flow turbulences provides a useful and reproducible means to quantify aortic regurgitation. It also allows serial atraumatic investigations as a diagnostic alternative to color Doppler examination in patients less suitable for echocardiographic evaluation and may prove helpful in monitoring the natural course of aortic valve disease.
authors.affiliation: Abteilung für Kardiologie, Universitäts-Krankenhauses Hamburg-Eppendorf.
authors.forename: G
authors.initials: G
authors.lastname: Feilcke
authors.forename: F
authors.initials: F
authors.lastname: Münster
authors.forename: V
authors.initials: V
authors.lastname: Siglow
authors.forename: D H
authors.initials: DH
authors.lastname: Koschyk
authors.forename: R P
authors.initials: RP
authors.lastname: Spielmann
authors.forename: C A
authors.initials: CA
authors.lastname: Nienaber
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000187:drug effects / Q000503:physiopathology; D001022:Aortic Valve Insufficiency / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001027:Aortography; D004071:Digitalis Glycosides / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D015150:Echocardiography, Doppler / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D004071:Digitalis Glycosides; D004232:Diuretics; D014665:Vasodilator Agents
vernacular_title: Dynamische Magnetresonanztomographie bei Insuffizienz der Aortenklappe: Methodischer Vergleich mit der Aortographie und der Farbdoppler-Echokardiographie.