[The immunological indices in the intranasal method of revaccination with a live measles vaccine].
Immunological parameters of the blood were studied in intranasal revaccination with a live measles vaccine (LMV) from the strain L-16. Alongside with specific immune response, LMV was shown to produce nonspecific changes in the system of immunocompetent cells the amount and duration of which were vaccine dose-dependent. The immunomodulating activity of LMV administered by different routes was different. Especially marked was the difference in the degree of side effect of the vaccine on T-lymphocytes. A dose of 10,000 TCD50 in 0.5 ml of LMV produced sufficient antigenic stimulation by the intranasal route of revaccination being quite satisfactory from the point of view of immunological safety of measles vaccine.
Iuminova
N V
NV
Krasnova
V P
VP
Liashenko
V A
VA
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D007117:Immunization, Secondary / Q000379:methods*; D016131:Lymphocyte Subsets / Q000276:immunology; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D013997:Time Factors
D008458:Measles Vaccine
Immunologicheskie pokazateli pri intranazal'nom sposobe revaktsinatsii zhivoĭ korevoĭ vaktsinoĭ.