title: [Tissue necrosis: a side effect of sodium diclofenac: report of cases and discussion of the physiopathology].
abstract: Diclofenac sodium is a non-steroidal anti-inflammatory widely used drug both in the treatment of the rheumatic diseases and as analgesic. The fact that is a potent analgesic spread its use to almost all fields in medicine, increasing the reports of adverse effects associated with it. The main complications reported are gastrointestinal, dermatological and of the central nervous system. The authors present seven cases that developed tissue necrosis as a result of the intramuscular injection of diclofenac sodium. Because of the low incidence or this adverse effect, a review is carried out and the physiopathologic mechanisms likely to be involved are discussed. Our aim is to warn against the indiscriminate intramuscular use of this drug.
authors.affiliation: Disciplina de Cirurgia do Trauma, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo.
authors.forename: M
authors.initials: M
authors.lastname: Giovannetti
authors.forename: M A
authors.initials: MA
authors.lastname: Machado
authors.forename: M
authors.initials: M
authors.lastname: Borrelli Júnior
authors.forename: C I
authors.initials: CI
authors.lastname: Ikejiri
authors.forename: N
authors.initials: N
authors.lastname: Alonso
authors.forename: P D
authors.initials: PD
authors.lastname: Branco
mesh_terms: D000328:Adult; D000368:Aged; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D004008:Diclofenac
vernacular_title: Necrose tecidual: efeito colateral do diclofenaco de sódio, relato de casos e discussão da fisiopatologia.