title: Effect of hypoxemia on the cardiovascular response to intracranial hypertension in postnatal lambs.
abstract: Large increases in intracranial pressure in fetal sheep result in more potent peripheral vasoconstriction and better maintenance of cerebral O2 consumption (CMRO2) than in postnatal sheep. The fetus is exposed to a lower PO2. We tested the hypothesis that low PO2 in postnatal lambs potentiates peripheral vasoconstriction and better maintains cerebral perfusion pressure and CMRO2. Pentobarbital-anesthetized lambs, 2-7 days old, were ventilated with either room air (n = 7) or a low O2 mixture to reduce arterial O2 saturation to 50% (n = 7). Elevation of intracranial pressure to within 3-5 mmHg of baseline mean arterial pressure for 30 min by ventricular fluid infusion initially caused a similar increase in arterial pressure in the normoxic [11 +/- 3 (SE) mmHg] and hypoxic (14 +/- 2 mmHg) groups. Plasma catecholamines increased more rapidly in the hypoxic group. However, plasma vasopressin levels were substantially elevated by hypoxia alone and failed to increase further with elevated intracranial pressure. Moreover, there was no significant difference between groups in the steady-state increase in arterial pressure, and microsphere-determined blood flow to intestines, kidney, skin, and muscle did not decrease in either group. Consequently, cerebral perfusion pressure, regional cerebral blood flow, and CMRO2 were reduced similarly in both groups. Therefore, hypoxemia failed to potentiate the postnatal pressor response. Low PO2 is unlikely to be the major mechanism for the potent Cushing response in the fetus.
authors.affiliation: Department of Anesthesiology/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore 21287.
authors.forename: M L
authors.initials: ML
authors.lastname: Kearney
authors.forename: J E
authors.initials: JE
authors.lastname: Backofen
authors.forename: R C
authors.initials: RC
authors.lastname: Koehler
authors.forename: M D
authors.initials: MD
authors.lastname: Jones
authors.forename: R J
authors.initials: RJ
authors.lastname: Traystman
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure; D002302:Cardiac Output; D002560:Cerebrovascular Circulation; D004837:Epinephrine / Q000097:blood; D006439:Hemodynamics; D006454:Hemoglobins / Q000032:analysis; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D009638:Norepinephrine / Q000097:blood; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011559:Pseudotumor Cerebri / Q000097:blood / Q000503:physiopathology*; D012039:Regional Blood Flow; D012756:Sheep
chemical_list: D006454:Hemoglobins; D001127:Arginine Vasopressin; D010100:Oxygen; D009638:Norepinephrine; D004837:Epinephrine