title: Differential action of phenytoin and carbamazepine on cortical interhemispheric responses in young but not in adult rats.
abstract: Single as well as paired responses to stimulation of the contralateral sensorimotor cortex were recorded in adult and 12-day-old rats under urethane anesthesia. Carbamazepine (50 mg/kg i.p.) prolonged the peak latencies of single responses in both adult and young rats, while phenytoin (60 mg/kg i.p.) prolonged the latencies in adult animals but shortened them in the young ones. Excitability cycles of the amplitude of the initial positive-negative complex remained uninfluenced by either drug in both age groups. Since solvent alone did not induce any effects in either test, our results demonstrate a qualitative change in the action of phenytoin during development.
authors.affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
authors.forename: P
authors.initials: P
authors.lastname: Mares
authors.forename: J
authors.initials: J
authors.lastname: Seidl
authors.forename: J
authors.initials: J
authors.lastname: Nováková
mesh_terms: D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology*; D004558:Electric Stimulation; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D010433:Pentylenetetrazole; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*
chemical_list: D002220:Carbamazepine; D010672:Phenytoin; D010433:Pentylenetetrazole