title: A high-resolution linkage map of human 9q34.1.
abstract: A map comprising 16 distinct markers with heterozygosities of 0.61-0.92 for a 10-cM region of human 9q34.1 is presented. The map incorporates four genes and has a maximum intermarker interval of 2.1 cM. Markers were analyzed in the Venezuelan reference pedigrees and all were placed uniquely in the map with a minimum likelihood of 676:1. The map should prove useful in analysis of families segregating dystonia and tuberous sclerosis, as the DYT1 and TSC1 loci map within this region.
authors.affiliation: Division of Experimental Medicine and Hematology-Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: E P
authors.initials: EP
authors.lastname: Henske
authors.forename: L
authors.initials: L
authors.lastname: Ozelius
authors.forename: J F
authors.initials: JF
authors.lastname: Gusella
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: D J
authors.initials: DJ
authors.lastname: Kwiatkowski
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D004247:DNA / Q000235:genetics; D004421:Dystonia / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D010375:Pedigree; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014402:Tuberous Sclerosis / Q000235:genetics
chemical_list: D000017:ABO Blood-Group System; D005819:Genetic Markers; D004247:DNA