The dorsal cochlear nucleus of the adult lurcher mouse is specifically invaded by embryonic grafted Purkinje cells.
The fate of embryonic Purkinje cells grafted over the brainstem surface of the adult Lurcher mouse was analyzed using anti-calbindin (CaBP) immunocytochemistry. Purkinje cells are able to migrate specifically into the molecular layer of the host dorsal cochlear nucleus (DCoN) and develop dendritic trees that are practically isoplanar, suggesting synaptic interactions with the parallel fibres of the DCoN. These results provide a new argument in favour of the homology between the cerebellum and the DCoN.
Dumesnil-Bousez
N
N
INSERM U-106, Neuromorphologie: développment et évolution, Hôpital de la Salpêtrière, Paris, France.
Sotelo
C
C
D000818:Animals; D064026:Calbindins; D017626:Cochlear Nucleus / Q000502:physiology*; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D007150:Immunohistochemistry; D051379:Mice; D008818:Mice, Neurologic Mutants; D011689:Purkinje Cells / Q000637:transplantation*; D064030:S100 Calcium Binding Protein G / Q000032:analysis
D064026:Calbindins; D064030:S100 Calcium Binding Protein G