title: Novel antitumor antibiotics, saptomycins. I. Taxonomy of the producing organism, fermentation, HPLC analysis and biological activities.
abstract: Streptomyces sp. HP530 was found to produce novel antitumor antibiotics, saptomycins, closely related to the pluramycin-group and was further found to mutate frequently. The natural mutant produced several new saptomycins as determined by HPLC analyses. We isolated saptomycins A, B, C1, C2 and F from the parent strain and saptomycins D, E, G and H from the mutant. The saptomycins showed antimicrobial activities and potent antitumor activities against human or murine tumor cell lines in vitro and against Meth A fibrosarcoma in vivo. In particular, saptomycin D was most effective component in vivo of all saptomycins.
authors.affiliation: Pharmaceutical Research Laboratories, Sapporo Breweries, Ltd., Shizuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Nakakita
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Enoki
authors.forename: H
authors.initials: H
authors.lastname: Uchida
authors.forename: M
authors.initials: M
authors.lastname: Munekata
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005285:Fermentation; D005354:Fibrosarcoma / Q000188:drug therapy*; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C071018:saptomycin D; C071019:saptomycin E