[Protective effects of 3, 6-dimethamidodibenzopyriodinium citrate on myocardial injury induced by ischemia and reperfusion in rats].
3, 6-Dimethamidodibenzopyriodonium citrate (I-65) 0.5 and 1 mg.kg-1 pretreatment reduced the size of myocardial infarct after ischemia for 40 min and reperfusion for 120 min. I-65 0.5 mg.kg-1 decreased myocardial creatine kinase, lactate dehydrogenase release, and Ca2+ accumulation after ischemia for 40 min and reperfusion for 120 min. The results show that I-65 prevents cardiac ischemia and reperfusion injury and the effect is considered to be related to inhibition of myocardial Ca2+ accumulation.
Deng
X L
XL
Department of Pharmacology, Xi-an Medical University, China.
Qiu
P L
PL
Liu
J T
JT
Chen
S Y
SY
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009861:Onium Compounds / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002121:Calcium Channel Blockers; D009861:Onium Compounds; C056078:3,6-dimethylaminodibenzopyriodonium citrate; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D002118:Calcium