[Changes in the physical characteristics of the lung can account for the improvement observed after ultrafiltration in patients with moderate heart failure].
Ultrafiltration improves the clinical condition of patients with moderate congestive heart failure. Ultrafiltration (1895 +/- 120 ml of plasma water, rate 600 ml/h, veno-venous bypass) was performed in 30 patients with moderate congestive heart failure in stable clinical conditions. The effects of ultrafiltration were assessed through pulmonary function and cardiopulmonary exercise tests performed before and 30 days after the procedure. Vital capacity, forced expiratory volume (1 s) and maximal voluntary ventilation improved as improved exercise performance (increase in oxygen consumption at peak exercise and at anaerobic threshold). Tidal volume at anaerobic threshold and at peak exercise increased by 10% with no changes in respiratory rate. This suggests that ultrafiltration induces changes at the physical characteristics of the lungs probably related to changes in lung water content.
Agostoni
P G
PG
Istituto di Cardiologia, Università degli Studi, IRCCS, Milano.
Marenzi
G C
GC
Pepi
M
M
Doria
E
E
Schianni
M
M
Salvioni
A
A
Perego
G
G
Lauri
G
G
Giraldi
F
F
Grazi
S
S
D000368:Aged; D055592:Biophysical Phenomena; D001703:Biophysics; D005080:Exercise Test; D005541:Forced Expiratory Volume; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006440:Hemofiltration; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008451:Maximal Voluntary Ventilation; D008875:Middle Aged; D014797:Vital Capacity
Modificazioni delle caratteristiche fisiche del polmone possono spiegare il miglioramento osservato dopo ultrafiltrazione nei pazienti con scompenso cardiaco moderato.