A note on the complex metabolism of danthron infused into the rat.
Danthron infused intravenously in rats shows a complex dose-dependent pattern of metabolism and excretion. The metabolites, particularly the more polar ones, are in general excreted predominantly in bile, to a lesser extent in urine. They can be separated as metabolite groups according to polarity and molecular size on a Sephadex LH 20 column. The present paper describes a further study within a bile-derived metabolite group, which proved to be particularly heterogeneous. It contained more than a dozen metabolites, which were conjugates of four different aglycons including the parent danthron. 1H NMR spectral data for danthron monosulfate and monoglucuronide are also presented.
Sund
R B
RB
Department of Pharmacology, University of Oslo, Norway.
Junker
T
T
Malterud
K E
KE
D000818:Animals; D000880:Anthraquinones / Q000378:metabolism* / Q000493:pharmacokinetics; D001646:Bile / Q000378:metabolism; D002400:Cathartics / Q000378:metabolism* / Q000493:pharmacokinetics; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D006016:Glycolates / Q000032:analysis; D007262:Infusions, Intravenous; D009682:Magnetic Resonance Spectroscopy; D051381:Rats
D000880:Anthraquinones; D002400:Cathartics; D006016:Glycolates; C004315:danthron