In vitro interaction between clindamycin and trimethoprim in combination on staphylococci.
The in-vitro interaction between clindamycin and trimethoprim was tested on 10 staphylococcal clinical isolates by the checkerboard technique and by the time-kill curve. Indifference was demonstrated against seven of these strains and antagonism against three. The clindamycin/trimethoprim combination is of no value if the purpose of the combination is to obtain synergy against staphylococci. However, the combination is useful against mild polymicrobial infections due to Gram-positive aerobes, anaerobes and Enterobacteriaceae.
el-Baz
W
W
Department of Medicine, Ain-Shams University, Cairo, Egypt.
Abd-el Hamid
T
T
Tantawi
A
A
Sabbour
M S
MS
D002981:Clindamycin / Q000494:pharmacology; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D014295:Trimethoprim / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism
D002981:Clindamycin; D014295:Trimethoprim; D001618:beta-Lactamases