title: Pregnancy complicated by the May-Hegglin anomaly.
abstract: May-Hegglin anomaly is a prepotent autosomal hereditary disease characterized by giant thrombocytes, thrombocytopenia and continuous appearance of inclusion bodies (Döhle like corpuscle) in the cytoplasm of granulocytes. In this report we report our experience of a case whose pregnancy was complicated by this disease. This anomaly is rare and there are only 15 families reported in this country. The only clinical symptom is the tendency to bleed, but since this is not rare, it may be necessary to consider examination of peripheral blood in every case of thrombocytopenia. If this disease complicates pregnancy, it is important to plan the mode of delivery to consider both the maternal and fetal prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Honnma
authors.forename: M
authors.initials: M
authors.lastname: Ishida
authors.forename: F
authors.initials: F
authors.lastname: Sano
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Takayanagi
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000473:pathology*; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006098:Granulocytes / Q000473:pathology*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D013577:Syndrome; D013921:Thrombocytopenia / Q000150:complications*