title: Further studies on the adjuvanticity of stearyl tyrosine and ester analogues.
abstract: A new family of immunoadjuvants, long-chain stearyl esters of amino acids and peptides, are described and examined with bacterial and viral vaccines. The parent compound, stearyl tyrosine, displayed significant adjuvant activity with these vaccines. Stearyl glycyl glycine displayed superior activity with viral vaccines. A number of analogues of stearyl tyrosine were adjuvant-active. Further, these adjuvants were able to elicit a neutralizing antibody response. Stearyl tyrosine and stearyl ester analogues represent promising adjuvants for human vaccines.
authors.affiliation: Immunomodulator Research, BioChem Pharma Inc., Laval, Quebec, Canada.
authors.forename: C L
authors.initials: CL
authors.lastname: Penney
authors.forename: D
authors.initials: D
authors.lastname: Ethier
authors.forename: G
authors.initials: G
authors.lastname: Dionne
authors.forename: A
authors.initials: A
authors.lastname: Nixon-George
authors.forename: H
authors.initials: H
authors.lastname: Zaghouani
authors.forename: F
authors.initials: F
authors.lastname: Michon
authors.forename: H
authors.initials: H
authors.lastname: Jennings
authors.forename: C A
authors.initials: CA
authors.lastname: Bona
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity; D004952:Esters / Q000276:immunology / Q000494:pharmacology; D005260:Female; D006678:HIV / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009345:Neisseria meningitidis / Q000276:immunology; D009842:Oligopeptides / Q000494:pharmacology; D017955:Poliovirus / Q000276:immunology; D014121:Toxoids / Q000276:immunology / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000276:immunology / Q000494:pharmacology; D014764:Viral Proteins / Q000276:immunology / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D000596:Amino Acids; D004952:Esters; D006514:Hepatitis B Surface Antigens; D009842:Oligopeptides; D014121:Toxoids; D014764:Viral Proteins; D014443:Tyrosine; C045245:stearyl tyrosine