Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid.
Superoxide anion reacts with hypochlorous acid to yield free hydroxyl radicals, as shown by the hydroxylation of benzoate. This reaction is analogous to the Haber-Weiss reaction but in the absence of metal ions is at least six orders of magnitude faster.
Candeias
L P
LP
Cancer Research Campaign Gray Laboratory, Northwood, Middlesex, UK.
Patel
K B
KB
Stratford
M R
MR
Wardman
P
P
D002851:Chromatography, High Pressure Liquid; D005720:Gamma Rays; D017665:Hydroxyl Radical / Q000378:metabolism*; D006997:Hypochlorous Acid / Q000378:metabolism*; D008956:Models, Chemical; D009504:Neutrophils / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid