title: Intratesticular serous cystadenoma of borderline malignancy. A pathological, histochemical and DNA content study of a case with long-term follow-up.
abstract: A 61-year-old man presented with a painless right testicular swelling of 6 months duration. A right orchiectomy was performed and pathological examination showed an intratesticular serous borderline tumour (SBT). Immunohistochemical staining was positive for carcinoembryonic antigen, LeuM1, B72.3, S100-protein, Ca125, cytokeratins AE1/AE3 and vimentin, suggesting a Müllerian origin or differentiation. DNA image analysis revealed an aneuploid histogram. The favorable outcome of the patient confirms that testicular SBTs behave as non-aggressive tumours, even when characterized by aneuploid DNA content.
authors.affiliation: Department of Pathology, University of Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Nictolis
authors.forename: S
authors.initials: S
authors.lastname: Tommasoni
authors.forename: G
authors.initials: G
authors.lastname: Fabris
authors.forename: J
authors.initials: J
authors.lastname: Prat
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D018293:Cystadenoma, Serous / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm