Human papilloma virus infection and Ki-ras oncogene in paraffin-embedded squamous carcinomas of the cervix.
42 paraffin-embedded squamous cervical carcinomas were screened for the presence of human papilloma virus (HPV; 6b, 11, 16, 18) and for activation of the Ki-ras oncogene family by polymerase chain reaction. In 72% of cases we found one or more HPV types, but no mutations of the Ki-ras gene (codon 12-1 and 61-1, 61-2 and 61-3) were found. We conclude that mutations of the Ki-ras oncogene, at the positions analyzed, are not likely to be involved in the events leading to cervical carcinogenesis.
Falcinelli
C
C
II Institute of Obstetrics and Gynecology, University La Sapienza, Rome, Italy.
Luzi
P
P
Alberti
P
P
Cosmi
E V
EV
Anceschi
M M
MM
D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000235:genetics / Q000382:microbiology*; D004273:DNA, Neoplasm / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D009154:Mutation; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000382:microbiology*; D016612:Paraffin Embedding; D014412:Tumor Virus Infections / Q000150:complications / Q000382:microbiology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000235:genetics / Q000382:microbiology*
D004273:DNA, Neoplasm; D004279:DNA, Viral