title: Idarubicin is active on MDR cells: evaluation of DNA synthesis inhibition on P388 cell lines.
abstract: Multidrug resistance is frequently found in patients affected by hematological malignancies and has been related to a poor prognosis of acute leukemia. In the present paper we report results concerning the activity of idarubicin, an anthracycline derivative, on the leukemic P388 and P388 doxorubicin-resistant cell lines. The results clearly show that idarubicin inhibits DNA synthesis in the resistant cell line more actively than doxorubicin.
authors.affiliation: Hematology Department, University of Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Petrini
authors.forename: L
authors.initials: L
authors.lastname: Mattii
authors.forename: P
authors.initials: P
authors.lastname: Valentini
authors.forename: A R
authors.initials: AR
authors.lastname: Sabbatini
authors.forename: B
authors.initials: B
authors.lastname: Grassi
authors.forename: M
authors.initials: M
authors.lastname: Grandi
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004317:Doxorubicin / Q000494:pharmacology; D004351:Drug Resistance; D015255:Idarubicin / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000378:metabolism; D051379:Mice; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014407:Tumor Cells, Cultured
chemical_list: D014316:Tritium; D004317:Doxorubicin; D004247:DNA; D013936:Thymidine; D015255:Idarubicin