Possible reversal of ageing and other mitochondrial deficiencies through retroviral transfection of mitochondrially encoded proteins to the nucleus.
This paper puts forward the hypothesis that ageing processes and a number of mitochondrially related diseases can be reversed or cured respectively. It briefly discusses the role of the mitochondrial genome in ageing and a number of inherited and age-related diseases. A rationale is then suggested which involves the utilization of retroviruses in translocating mitochondrial encoded proteins to the nucleus. Finally a number of problems which may arise from this translocation are discussed.
Hoeben
P
P
School of Life Science, Queensland University of Technology, Brisbane, Australia.
D000375:Aging / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D017353:Gene Deletion; D006801:Humans; D008322:Mammals; D008928:Mitochondria / Q000378:metabolism*; D017237:Mitochondrial Encephalomyopathies / Q000235:genetics*; D008954:Models, Biological; D010641:Phenotype; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics; D012190:Retroviridae / Q000235:genetics / Q000378:metabolism*; D014162:Transfection
D011506:Proteins