title: Respiratory responses to electrical and chemical stimulation of the area postrema in the rabbit.
abstract: 1. The respiratory role of the area postrema (AP) has been investigated in pentobarbitone- or alpha-chloralose-anaesthetized, vagotomized, paralysed and artificially ventilated rabbits, by means of electrical stimulation and microinjections of DL-homocysteic acid (DLH). Phrenic nerve activity was used as an index of central respiratory drive. 2. Bipolar electrical or chemical stimulation (microinjections of DLH, 5-30 nl; 160 mM) of the caudal compact portion of the AP provoked excitatory effects on the inspiratory motor output, without apparent changes in the arterial blood pressure. 3. Depressant effects on inspiratory activity, accompanied on some occasions by changes in arterial blood pressure (as a rule, increases > or = 30 mmHg) were induced by DLH microinjections in close neighbouring areas (including the medial part of the nucleus tractus solitarii) or in the IV ventricle. 4. These results support a role for the AP in the neural control of respiration. The findings are discussed in connection with other autonomic functions to which the AP has been reported to contribute, in different animal species.
authors.affiliation: Dipartimento di Scienze Fisiologiche, Università di Firenze, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Srinivasan
authors.forename: F
authors.initials: F
authors.lastname: Bongianni
authors.forename: G A
authors.initials: GA
authors.lastname: Fontana
authors.forename: T
authors.initials: T
authors.lastname: Pantaleo
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D006710:Homocysteine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008839:Microelectrodes; D008845:Microinjections; D009476:Neurons, Efferent / Q000187:drug effects / Q000502:physiology; D010791:Phrenic Nerve / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects / Q000502:physiology*; D013268:Stimulation, Chemical
chemical_list: D006710:Homocysteine; C007956:homocysteic acid