title: Rate-dependent functional properties of retrograde atrioventricular nodal conduction in experimental animals.
abstract: While rate-dependent atrioventricular (AV) nodal functional properties play a major role in determining antegrade AV nodal conduction, their existence and characteristics have not been assessed during retrograde AV nodal impulse propagation. Pacing protocols were used to study selectively AV nodal recovery, facilitation, and fatigue in 6 isolated, superfused rabbit AV nodal preparations and in 11 morphine-chloralose anesthetized dogs. All three properties were identifiable during retrograde AV nodal activation in rabbits. Retrograde recovery and fatigue were clearly demonstrated in dogs, but facilitation could not be evaluated because of echo beats during retrograde premature stimulation. Functional properties were qualitatively similar during retrograde and antegrade propagation; however, important quantitative differences were noted. The time constant for recovery from activation was significantly greater in the retrograde [rabbits, 69 +/- 8 (SE) ms; dogs, 93 +/- 11 ms] compared with the antegrade direction (rabbits, 50 +/- 5 ms; dogs, 58 +/- 4 ms; P < 0.05 vs. retrograde for each species). The magnitude of fatigue resulting from sustained increases in rate was also substantially greater in the retrograde direction in both rabbits (17 +/- 2 vs. 10 +/- 1 ms antegrade, P = 0.01) and dogs (20 +/- 4 vs. 6 +/- 1 ms antegrade, P < 0.01). Conduction time and refractory period were both greater in the retrograde compared with antegrade direction, and directional differences in conduction properties were magnified as activation rate increased.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Montreal Heart Institute, Canada.
authors.forename: G
authors.initials: G
authors.lastname: O'Hara
authors.forename: R
authors.initials: R
authors.lastname: Gendreau
authors.forename: J
authors.initials: J
authors.lastname: Billette
authors.forename: F
authors.initials: F
authors.lastname: Amellal
authors.forename: M
authors.initials: M
authors.lastname: Nayebpour
authors.forename: M
authors.initials: M
authors.lastname: Talajic
authors.forename: S
authors.initials: S
authors.lastname: Nattel
mesh_terms: D000818:Animals; D001283:Atrioventricular Node / Q000502:physiology*; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D011817:Rabbits