Urinary fibronectin in diagnosis and follow-up of patients with urinary bladder cancer.
The levels of fibronectin in urine from 106 patients with urinary bladder cancer, from 13 patients with benign urological disease and from 24 healthy control individuals were determined by an enzyme-linked immunosorbent assay (ELISA). The fibronectin levels in urine from patients with bladder cancer were higher than in patients with benign urothelial disease and in healthy controls. In 9 patients with bladder cancer, sampling was done both pre- and post-operatively. In these cases the fibronectin levels after operation were significantly lower than they had been before. Among 14 patients treated with BCG intravesically for superficial bladder tumours, those with complete remission of disease had less urinary fibronectin than those who did not respond to treatment. The data suggest that urinary fibronectin may be a useful marker for detecting urinary bladder cancer and for selecting patients for BCG treatment.
Malmström
P U
PU
Department of Urology, University of Uppsala, Sweden.
Larsson
A
A
Johansson
S
S
D000419:Albuminuria / Q000652:urine; D001500:BCG Vaccine / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000652:urine*; D005353:Fibronectins / Q000652:urine*; D005500:Follow-Up Studies; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000628:therapy / Q000652:urine; D014570:Urologic Diseases / Q000652:urine
D001500:BCG Vaccine; D014408:Biomarkers, Tumor; D005353:Fibronectins