Transvaginal ultrasonographic measurements of the fetal adrenal glands at 12 to 17 weeks of gestation.
OBJECTIVE
Our purpose was to compile normative data of fetal adrenal gland measurements between 12 and 17 weeks' gestation with transvaginal ultrasonography.


METHODS
Transvaginal ultrasonographic measurements of the fetal adrenal length and adrenal-to-kidney length ratio calculations were performed on 100 normal fetuses at 12 to 17 weeks' gestation. The diameters of the fetal adrenals and kidneys on each side were measured, and nomograms were generated. These parameters were also measured in two fetuses whose mothers were treated for congenital adrenal hyperplasia.


RESULTS
The measurements of the maximal longitudinal axis of the right and left fetal adrenal glands showed a linear increase with fetal age between 12 and 17 weeks of gestation. The adrenal-to-kidney length ratio decreased linearly between these gestational ages. In maternal congenital adrenal hyperplasia treated with glucocorticosteroids the fetal adrenals were small.


CONCLUSIONS
Fetal adrenal gland measurements in the early second trimester show a linear progressive growth between 12 and 17 weeks' gestation.
Bronshtein
M
M
Department of Obstetrics and Gynecology A, Rambam Medical Center, Haifa, Israel.
Tzidony
D
D
Dimant
M
M
Hajos
J
J
Jaeger
M
M
Blumenfeld
Z
Z
D000311:Adrenal Glands / Q000196:embryology* / Q000473:pathology; D000328:Adult; D005260:Female; D005865:Gestational Age; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006965:Hyperplasia; D007668:Kidney / Q000196:embryology; D011247:Pregnancy; D011248:Pregnancy Complications; D012016:Reference Values; D012044:Regression Analysis; D016216:Ultrasonography, Prenatal / Q000379:methods*; D014621:Vagina
D005938:Glucocorticoids