The role of lipoproteins in the delivery of tumour-targeting photosensitizers.
1. Serum lipoproteins play an important role in the in vivo transport of several porphyrinoid derivatives having a moderate or high degree of hydrophobicity. 2. There appears to exist a correlation between the extent of photosensitizer association with low-density lipoproteins (LDL) and the efficiency of tumour targeting by some classes of photosensitizers, such as differently sulphonated porphyrins and phthalocyanines, haematoporphyrin dialkylethers and unsubstituted phthalocyanines and naphthalocyanines. 3. In all cases, LDL-carried photosensitizers are preferentially released to malignant cells; hence, direct cell damage appears to be the major determinant of tumour damage consequent to photodynamic therapy. 4. Present evidence suggests that the LDL-associated photosensitizer is accumulated by tumour cells largely via a receptor-mediated endocytotic process. 5. Thus, the use of delivery systems for orientating a systemically injected photosensitizer towards lipoproteins has been explored; promising results have been obtained by incorporation of the dye into liposomal vesicles, oil emulsions or inclusion complexes, as well as by precomplexation of the dye with LDL. 6. Moreover, a suitable choice of the chemical constituents of the delivery system and the experimental conditions allows one to modulate the photosensitizer distribution among the different lipoproteins. 7. The occurrence of tumour-targeting strategies other than the LDL pathway is briefly discussed.
Jori
G
G
Department of Biology, University of Padova, Italy.
Reddi
E
E
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D016503:Drug Delivery Systems; D008074:Lipoproteins / Q000502:physiology*; D008077:Lipoproteins, LDL / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism*; D017319:Photosensitizing Agents / Q000493:pharmacokinetics*
D008074:Lipoproteins; D008077:Lipoproteins, LDL; D017319:Photosensitizing Agents