title: Relationship between alpha-aminolevulinic acid dehydratase activity, free erythrocyte protoporphyrin concentration and blood lead in calves from lead contaminated farm.
abstract: In order to investigate useful indicators of lead contamination, 108 Japanese Black calves from a lead-contaminated farm were used. The lead concentrations in blood (Ph-B), delta-aminolevulinic acid dehydratase (ALA-D) activities, and free erythrocyte protoporphyrin (FEP) concentrations were examined. A significant negative correlation was obtained between Pb-B concentrations and ALA-D activities (r = -0.621, p < 0.01). A significant positive correlation was obtained between Ph-B concentrations and FEP concentrations (r = 0.850, p < 0.01). The calves were divided by Pb-B concentrations (micrograms/100 ml) into 5 groups (A = < or = 30, B = 31 approximately 90, C = 91 approximately 150, D = 151 approximately 210, E = > or = 211) to observe the relation of ALA-D activities, FEP concentrations and ALA-D activities in group B (r = -0.706, p < 0.05). A significant positive correlation was obtained between Pb-B concentrations and FEP concentrations in groups A, B and D (A = r = 0.496, p < 0.01; B = r = 0.686, p < 0.01; D = r = 0.529, p < 0.05). These results indicate that FEP concentrations were good indicators of lead contamination.
authors.affiliation: Department of Veterinary Internal Medicine I, School of Veterinary Medicine, Azabu Univesity, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: A
authors.initials: A
authors.lastname: Katsumi
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000453:epidemiology; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000097:blood / Q000453:epidemiology / Q000662:veterinary*; D000623:Porphobilinogen Synthase / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*; D012044:Regression Analysis
chemical_list: D011524:Protoporphyrins; D007854:Lead; D000623:Porphobilinogen Synthase