Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine.
The influence of acute and chronic cocaine treatment on the expression of dopamine D2 receptor (D2R) mRNA was examined in the rat basal ganglia by in situ hybridization histochemistry. No significant alterations in D2R mRNA levels were observed in the striatum or the nucleus accumbens following acute or chronic cocaine. In the olfactory tubercle, acute cocaine (20 and 40 mg/kg, i.p.) was found to decrease D2R mRNA expression. Chronic cocaine (20 mg/kg, i.p. x 15 days), however, produced an increase in D2R mRNA levels in this region which was detected 24 h, but not 7 days after withdrawal. Acute and chronic cocaine have different effects on the regulation of D2R gene expression in the olfactory tubercle.
Spyraki
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Fishberg Research Center in Neurobiology, Mount Sinai School of Medicine, New York, NY 10029.
Sealfon
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SC
D000818:Animals; D001345:Autoradiography; D003042:Cocaine / Q000494:pharmacology*; D015342:DNA Probes; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005786:Gene Expression Regulation / Q000187:drug effects*; D008297:Male; D009833:Olfactory Pathways / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis*; D013462:Sulfur Radioisotopes; D013997:Time Factors
D015342:DNA Probes; D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D013462:Sulfur Radioisotopes; D003042:Cocaine