Effects of hypertonic saline solution (20%) on cardiodynamics during hemorrhagic shock.
The cardiodynamic effects of using hypertonic saline solution were analyzed in dogs after inducing hemorrhagic shock. Administration of 1.5 mL/kg 20% sodium chloride resulted in circulatory improvement: 200% increase in blood pressure, 260% increase in cardiac output, 60-70% increase in pulmonary arterial pressure, 66% increase in pulmonary wedge pressure, 200% increase in central venous pressure, 33% decrease in total peripheral resistance, and 40% decrease in pulmonary vascular resistance. The effects of sodium chloride on cardiodynamics probably resulted in elevation of preload and reduction of afterload.
Ogata
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First Department of Anesthesiology, School of Medicine, Dokkyo University, Tochigi Prefecture, Japan.
Luo
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D004285:Dogs; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D011652:Pulmonary Circulation / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000494:pharmacology*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D014655:Vascular Resistance / Q000187:drug effects
D012462:Saline Solution, Hypertonic