Behavioral activation by stimulation of a GABAergic mechanism in the preoptic area of rat.
The locomotor activity and grooming of conscious freely moving rats were recorded during a 60-min unilateral perfusion of the preoptic area with neuroactive compounds using the microdialysis technique. The GABA agonist, muscimol (10, 20 and 100 microM) induced a dose-dependent increase in locomotor activity and grooming which was attenuated by co-perfusion with the GABA antagonist, bicuculline (10 microM), and was blocked by systemic injection of haloperidol, a preferential dopamine D2 receptor antagonist (0.25 mg/kg). Muscimol-induced hyperactivity was associated with a simultaneous increase of striatal extracellular dopamine. These data suggest that the preoptic area is functionally linked with the extrapyramidal dopaminergic system possibly via GABAergic system.
Osborne
P G
PG
Department of Neuroscience, Osaka Bioscience Institute, Japan.
Mataga
N
N
Onoe
H
H
Watanabe
Y
Y
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001640:Bicuculline / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology; D003956:Dialysis; D004298:Dopamine / Q000502:physiology; D006120:Grooming / Q000187:drug effects; D006185:Habituation, Psychophysiologic; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009118:Muscimol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D009118:Muscimol; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D006220:Haloperidol; D004298:Dopamine; D001640:Bicuculline