title: Identification of a 16-kDa thymocyte membrane glycoprotein involved in the thymocyte/thymic medullary epithelial cell interaction.
abstract: We have previously described a type of lymphoepithelial interaction involving CD4+ CD8+ thymocytes and a medullary epithelial cell line (E-5). This interaction is mediated by the recently described gp23/45 epithelial adhesion molecule and an as yet unknown thymocyte receptor. The present work describes a thymocyte surface glycoprotein of 16 kDa which binds both to E-5 cells and to the purified gp23/45 adhesion molecule. In addition, a thymic lymphoma cell line (Ti-6), which interacts with the E-5 cells via the gp23/45 receptor, also present a 16-kDa glycoprotein on its surface. Taken together, the data suggest that the 16-kDa thymocyte surface glycoprotein participates in the binding between these cells and the thymic epithelium.
authors.affiliation: Institut Armand-Frappier, Laval, Québec, Canada.
authors.forename: J G
authors.initials: JG
authors.lastname: Amarante-Mendes
authors.forename: C
authors.initials: C
authors.lastname: Couture
authors.forename: E F
authors.initials: EF
authors.lastname: Potworowski
mesh_terms: D000818:Animals; D001345:Autoradiography; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002450:Cell Communication; D004591:Electrophoresis, Polyacrylamide Gel; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000302:isolation & purification / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins