title: Antipyretic effectiveness of acetaminophen in febrile seizures: ongoing prophylaxis versus sporadic usage.
abstract: A controlled clinical study compared the antipyretic effectiveness of acetaminophen administered at regular 4h intervals (group 1, n = 53) versus sporadic usage contingent upon a body temperature above 37.9 degrees C (group 2, n = 51) in 104 children presenting with simple febrile convulsions. The incidence of febrile episodes or temperature values were similar in spite of significantly larger amounts of acetaminophen administered to patients in group 1. Four and 4 children in groups 1 and 2, respectively, had a second episode of febrile seizures, in all of them within the first 24h of admission. We conclude that the prophylactic administration of acetaminophen in children with febrile seizures is not effective in the prevention of fever, the reduction of its degree, or in preventing the early recurrence of febrile seizures.
authors.affiliation: Paediatric Division, Assaf Harofeh Medical Centre, Sackler School of Medicine, Tel Aviv University, Zerifin, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Schnaiderman
authors.forename: E
authors.initials: E
authors.lastname: Lahat
authors.forename: T
authors.initials: T
authors.lastname: Sheefer
authors.forename: M
authors.initials: M
authors.lastname: Aladjem
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D003294:Seizures, Febrile / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D000082:Acetaminophen