title: Peripheral antinociceptive effects of morphine after burn injury.
abstract: In a double-blind study, 2 mg of morphine in saline, or saline only, was given subcutaneously into a second-degree bilateral leg-burn injury in 12 volunteers. Heat-pain thresholds and pressure-pain thresholds were significantly increased by local morphine administration. These results confirm experimental data demonstrating a peripheral antinociceptive effects of opioids in inflamed tissue.
authors.affiliation: Department of Anaesthesiology, Hvidovre University Hospital, Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Møiniche
authors.forename: J B
authors.initials: JB
authors.lastname: Dahl
authors.forename: H
authors.initials: H
authors.lastname: Kehlet
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D017288:Pain Threshold / Q000187:drug effects*
chemical_list: D009020:Morphine