title: Platelet aggregation inhibitors in a Bhutanese medicinal plant, shug chher.
abstract: The 90% methanol-soluble fraction of a Bhutanese medicinal plant, Shug Chher, exhibited inhibition of platelet aggregation induced by platelet activating factor. Bioassay-directed fractionation led to the isolation of four new labdane diterpenoids, 3 alpha, 15-dihydroxy-labda-8(17), 13E-diene (5), 3 alpha-hydroxy-labda-8(17), 13E-dien-15-oic acid (6), 3 alpha-hydroxy-labda-8(17), 12E, 14-trien-19-oic acid (7), and 3 alpha-acetoxyisocupressic acid (8) and four known diterpenoids, manool (1), 3 alpha-hydroxymanool (2), 3 alpha-hydroxy-12, 13E-biformene (3), and isocupressic acid (4). The structures of the new compounds were determined spectroscopically. Compounds 2, 3, and 5 inhibited platelet aggregation.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kagawa
authors.forename: K
authors.initials: K
authors.lastname: Tokura
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: H
authors.initials: H
authors.lastname: Kakushi
authors.forename: T
authors.initials: T
authors.lastname: Shike
authors.forename: J
authors.initials: J
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: P
authors.initials: P
authors.lastname: Dorji
authors.forename: L
authors.initials: L
authors.lastname: Subedi
mesh_terms: D001631:Bhutan; D006801:Humans; D066298:In Vitro Techniques; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors