title: A comment on the absence of calcium regulation of human thioredoxin reductase.
abstract: It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.
authors.affiliation: Arizona Cancer Center, Tucson 85715.
authors.forename: J E
authors.initials: JE
authors.lastname: Oblong
authors.forename: G
authors.initials: G
authors.lastname: Powis
mesh_terms: D002118:Calcium / Q000378:metabolism*; D006801:Humans; D010920:Placenta / Q000201:enzymology; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism*
chemical_list: D013880:Thioredoxin-Disulfide Reductase; D002118:Calcium