title: Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
abstract: Three novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A1 inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B1 was similarly cytotoxic, while quinolidomicin A2 was inactive against these tumor cells.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: M
authors.initials: M
authors.lastname: Matsuoka
authors.forename: K
authors.initials: K
authors.lastname: Shin-ya
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D005285:Fermentation; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008847:Micromonospora / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides; C084379:quinolidomicin A2; C084380:quinolidomicin B1; C084378:quinolidomicin A1