title: Fate of right ventricular hypertrophy in tetralogy of Fallot after corrective surgery.
abstract: To elucidate the reversibility of right ventricular (RV) myocardial hypertrophy in tetralogy of Fallot (TF), 30 patients underwent RV endomyocardial biopsies 1 to 25 years (mean 9.7 +/- 6.6) after corrective surgery. Myocardial cell diameter was evaluated by comparing histopathologic data with preoperative patients with TF and normal subjects. As a whole, postoperative cell diameter was smaller than that of age-matched preoperative patients with TF, and larger than that of age-matched normal subjects. In 7 patients without significant residual pulmonary stenosis whose preoperative data were also available, cell diameter significantly decreased after surgery (17.1 +/- 2.1 to 14.0 +/- 2.1 microns, p < 0.01). There was a positive correlation between postoperative cell diameter and age at study (p < 0.01). To negate the influence of age, cell diameter was expressed in terms of a percentage of age-matched normal values (percent cell diameter). There was no significant correlation between percent cell diameter and age at surgery, age at study or the follow-up periods. There were positive correlations between percent cell diameter and the following parameters: RV systolic pressure (p < 0.05), percent normal RV end-diastolic (p < 0.05) and end-systolic (p < 0.01) volumes. These results demonstrate that RV myocardial hypertrophy in TF can regress to some extent after corrective surgery if significant residual pulmonary stenosis is avoided.
authors.affiliation: First Department of Surgery, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mitsuno
authors.forename: S
authors.initials: S
authors.lastname: Nakano
authors.forename: Y
authors.initials: Y
authors.lastname: Shimazaki
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Kawamoto
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Kawashima
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001706:Biopsy; D002306:Cardiac Volume / Q000502:physiology; D048429:Cell Size; D002648:Child; D002675:Child, Preschool; D004699:Endocardium / Q000473:pathology; D005500:Follow-Up Studies; D006346:Heart Septum / Q000473:pathology; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000473:pathology* / Q000503:physiopathology; D007223:Infant; D009206:Myocardium / Q000473:pathology; D013771:Tetralogy of Fallot / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016278:Ventricular Function, Right / Q000502:physiology; D017725:Ventricular Pressure / Q000502:physiology