From gene to protein: determination of melanin synthesis.
Melanin production in mammals is regulated at a variety of levels (tissue, cellular, and subcellular), and many gene loci are involved in the determination of color patterns directed by the melanocyte. Many of the genes involved in these complex processes have now been cloned, and even the simplest mutation can lead to dramatic changes in the phenotype of the individual. Many, if not all, of the pigment related genes have pleiotropic effects on the development and differentiation of the organism, and perhaps because of this, the melanocyte is evolving as an important model for the study of gene regulation and action at the functional level. In view of the importance of pigmentation as a photoprotective barrier and as a cosmetic factor affecting appearance and social acceptance, the importance of these studies seems destined to increase significantly in the future.
Urabe
K
K
Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20892.
Aroca
P
P
Hearing
V J
VJ
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D005796:Genes / Q000235:genetics*; D006801:Humans; D008543:Melanins / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology
D008543:Melanins