title: Postoperative cauda syndrome caused by Staphylococcus aureus.
abstract: Toxic shock syndrome (TSS) is a well-defined clinical syndrome attributed to certain exotoxins produced by Staphylococcus aureus. The acute episode is often characterized by a toxic encephalopathy, possibly caused by direct neurotoxicity of these exotoxins, although this mechanism has never been proven. We describe a patient who developed TSS, meningitis and cauda equina syndrome simultaneously several days after lumbar laminectomy. A space-occupying lesion was excluded. Enterotoxin C-producing S. aureus was cultured from the surgical wound and the cerebrospinal fluid (CSF). The patient recovered from TSS but remained partially paralyzed. Presumably the cauda equina syndrome was caused by neurotoxic effects of the intrathecally produced S. aureus exotoxins. This case provides evidence for the neurotoxic effects of TSS-associated S. aureus exotoxins.
authors.affiliation: Bronovo Hospital, The Hague, The Netherlands.
authors.forename: S M
authors.initials: SM
authors.lastname: Arend
authors.forename: A V
authors.initials: AV
authors.lastname: Steenmeyer
authors.forename: P C
authors.initials: PC
authors.lastname: Mosmans
authors.forename: H A
authors.initials: HA
authors.lastname: Bijlmer
authors.forename: J W
authors.initials: JW
authors.lastname: van't Wout
mesh_terms: D000328:Adult; D002420:Cauda Equina; D004576:Electromyography; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use; D006801:Humans; D007796:Laminectomy / Q000009:adverse effects*; D008159:Lumbar Vertebrae; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D009408:Nerve Compression Syndromes / Q000175:diagnosis / Q000209:etiology*; D012772:Shock, Septic / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D013168:Spondylolisthesis / Q000601:surgery*; D013169:Spondylolysis / Q000601:surgery*; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D013211:Staphylococcus aureus; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D005436:Floxacillin; D014640:Vancomycin