Effects of anti-hyperlipidaemic agent or dietary protein restriction on progressive renal deterioration in adriamycin-induced nephropathy in rats.
Hyperlipidaemia is strongly suggested to contribute to the pathogenesis of glomerular sclerosis. This study intends to clarify the effects of either a lipid lowering agent, lovastatin (LO) or protein restriction (PR) on adriamycin (ADR)-induced progressive glomerular sclerosis in rats. During the study period both serum cholesterol and triglyceride were significantly reduced in ADR-injected rats with either lovastatin administration (ADR-LO) or protein restriction (ADR-PR) compared to those without such treatment (ADR-NP). At week 22, urinary protein excretion, serum creatinine, blood urea nitrogen, glomerular sclerosis and tubulointestinal alterations, which were marked in ADR-NP, were ameliorated in both ADR-LO and ADR-PR rats. ADR-LO resulted in a body weight similar to that in ADR-NP while ADR-PR induced a marked weight loss. An antihyperlipidaemic agent, such as lovastatin, seems to be a useful tool for the prevention of renal deterioration.
Washio
M
M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nanishi
F
F
Onoyama
K
K
Okuda
S
S
Fujishima
M
M
D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004044:Dietary Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D004317:Doxorubicin / Q000009:adverse effects; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D008148:Lovastatin / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008954:Models, Biological; D011507:Proteinuria / Q000139:chemically induced / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D014280:Triglycerides / Q000097:blood
D004044:Dietary Proteins; D014280:Triglycerides; D004317:Doxorubicin; D002784:Cholesterol; D008148:Lovastatin; D003404:Creatinine