Peripheral antinociceptive effects of morphine after burn injury.
In a double-blind study, 2 mg of morphine in saline, or saline only, was given subcutaneously into a second-degree bilateral leg-burn injury in 12 volunteers. Heat-pain thresholds and pressure-pain thresholds were significantly increased by local morphine administration. These results confirm experimental data demonstrating a peripheral antinociceptive effects of opioids in inflamed tissue.
Møiniche
S
S
Department of Anaesthesiology, Hvidovre University Hospital, Copenhagen, Denmark.
Dahl
J B
JB
Kehlet
H
H
D000328:Adult; D002056:Burns / Q000150:complications*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D017288:Pain Threshold / Q000187:drug effects*
D009020:Morphine