[A case of complete remission of metastatic skin carcinoma (erythema type) from advanced gastric cancer by CDDP administration].
A 75-year-old female with skin metastasis from advanced gastric cancer (portion A, tub2, ss beta, n2, P0H0, Borrmann 3-type) was successfully treated with CDDP at a dosage of 25 mg/body every week or two. She had undergone R2 curative subtotal gastrectomy in October 1986, and had orally taken tegafur 300 mg/day as postoperative adjuvant chemotherapy. Three years after the operation, she had skin erythema at chest and neck. A pathological examination revealed that the skin erythema was a metastasis of gastric cancer. After administration of 5-FU and MMC, the skin lesion diminished in size, but in November of 1990, it expanded again. Administration of 5-FU, MMC and epirubicin was not effective. The skin lesion expanded extensively and changed to nodular type. CDDP was intermittently administered from August 1991 to December 1991, 25 mg/body div. every week or two; the total volume of CDDP reached 225 mg. The metastatic skin carcinoma disappeared and a complete response was obtained. CEA, which had been high (190 ng/ml), regained the normal level. Thrombocytopenia and liver dysfunction developed as side effects, but reduced after cessation of CDDP administration. The patient has been well for 3 years and 6 months since the onset of the skin metastasis.
Makino
H
H
Dept. of Surgery, Kyoto Prefectural Yosanoumi Hospital.
Naito
K
K
Tsuruta
A
A
Kan
K
K
Toda
S
S
Yoshimura
N
N
Ohmori
Y
Y
Oka
T
T
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D000368:Aged; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
D002945:Cisplatin