title: Pharmacokinetic profile of two different pharmaceutical forms of theophylline (a slow release tablet and a syrup) after multiple dose administration to healthy human volunteers.
abstract: Due to the narrow therapeutic range of theophylline, plasma concentrations of this drug are monitored in patients undergoing chronic therapy. Slow-release preparations avoid the fluctuations in plasma levels and improve patient compliance. In this study, we have compared the pharmacokinetic profiles of a theophylline slow-release tablet and a syrup form, when administered in multiple doses to healthy adult volunteers. The classification based upon releasing patterns is confirmed.
authors.affiliation: Departamento de Farmacologia, Faculdade de Ciências Médicas, UNICAMP, Campinas, SP Brasil.
authors.forename: M N
authors.initials: MN
authors.lastname: Muscará
authors.forename: E A
authors.initials: EA
authors.lastname: Hofstätter
authors.forename: G
authors.initials: G
authors.lastname: de Nucci
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline