Lipoprotein(a) and treatment of chronic renal disease.
OBJECTIVE
To compare lipoprotein(a) [Lp(a)] and albumin concentrations in patients with chronic renal disease receiving different forms of treatment and to determine, if any, the relationship between these variables.


METHODS
A prospective cross-sectional, case-controlled study.


METHODS
A tertiary referral nephrology and dialysis unit.


METHODS
Forty-four consecutive non-diabetic patients with chronic renal failure treated by renal transplantation (n = 18), haemodialysis (n = 18), continuous ambulatory peritoneal dialysis (CAPD; n = 8), and 30 healthy controls from subjects drawn from University personnel were studied.


METHODS
Fasting morning venous blood was analysed for Lp(a), albumin, total cholesterol and glucose concentrations.


METHODS
Comparison of plasma levels of these variables between the sub-groups.


RESULTS
Concentrations (median; 95% CI) of Lp(a) were significantly (P < 0.05) higher (38.4 mg dl-1; range 15.4-72.0) and of albumin lower (31.6 g l-1; range 28-35.2) in the CAPD group compared with both control subjects and other groups of chronic renal disease patients.


CONCLUSIONS
The elevated Lp(a) concentrations seen only in association with reduced albumin concentrations in CAPD patients suggest a regulatory role for albumin with albumin losses stimulating production of Lp(a).
Buggy
D
D
Department of Nephrology, Meath Hospital, Dublin, Ireland.
Breathnach
A
A
Keogh
B
B
Cooke
T
T
Feely
J
J
D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D016030:Kidney Transplantation; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011446:Prospective Studies; D006435:Renal Dialysis
D017270:Lipoprotein(a)