[The effect on changes in serum lipids and factors that may affect those changes after administration of icosapentaenoic acid ethyl ester].
The effects of high-purity IPA-E administration on changes in serum lipids and factors that may affect those changes were investigated in 55 patients with arteriosclerotic disease (34 males and 21 females, aged 43-85) under a regular daily diet. Daily administration of 1800 mg or 900 mg IPA-E resulted in a significant decrease or tendency to decrease in serum TG, TC and LDL-C 4 weeks after the initial administration, which continued throughout the administration period. Apo-protein analysis revealed a significant increase in A-I and a significant decrease in B and E after the administration of IPA-E. Lipoprotein analysis disclosed decreasing tendency of VLDL, IDL, LDL and TG, where the changes in VLDL-C, VLDL-TG and TG were significant. The amount and rate of change in TG, TC and LDL-C after IPA-E administration had a significant negative correlation with their respective pre-administration values. The decrease from pre-administration values was significant for patients with abnormal values in both dosage groups. The average rate of decrease in TC and LDL-C were greater in the group receiving administration of 1800 mg/day than that receiving 900 mg/day, but the difference in the change was not significant between the 2 groups. Correlations between the amount or rate of decrease in TC or LDL-C and the baseline value, achieved value, or amount or rate of increase in plasma IPA concentration and IPA/AA ratio were not significant. However, the negative correlation between the rate of change in TG and achieved IPA concentration was significant.(ABSTRACT TRUNCATED AT 250 WORDS)
Saga
T
T
Department of Internal Medicine, Fukui Prefectural Hospital.
Aoyama
T
T
Takekoshi
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001059:Apoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001059:Apoproteins; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; C035276:eicosapentaenoic acid ethyl ester; D002784:Cholesterol; D015118:Eicosapentaenoic Acid