Multiple hamartoma syndrome with osteosarcoma.
Multiple hamartoma syndrome, also known as Cowden's disease, is a rare genodermatosis with characteristic mucocutaneous lesions associated with multiple internal abnormalities. We describe a patient having classic dermatologic manifestations of Cowden's disease and multiple neoplasia including follicular adenocarcinoma of the thyroid gland with lung metastasis, intraductal breast carcinoma within a fibroadenoma, and an osteosarcoma. To our knowledge, this is the first reported case of an osteosarcoma in Cowden's disease.
Yen
B C
BC
Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029-6574.
Kahn
H
H
Schiller
A L
AL
Klein
M J
MJ
Phelps
R G
RG
Lebwohl
M G
MG
D000328:Adult; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology*; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000473:pathology*; D006801:Humans; D012516:Osteosarcoma / Q000209:etiology / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000209:etiology / Q000473:pathology*