title: Further evidence for the interaction of the antimalarial drug amodiaquine with ferriprotoporphyrin IX.
abstract: Evidence for complex formation of the antimalarial drug amodiaquine (AD) with ferriprotoporphyrin IX (FP) in aqueous medium is presented, in addition to previous preliminary data. A mole ratio of one between the complex components is determined for the insoluble complex at pH 6.7-6.8. Mössbauer data obtained at pH 7-8 and at higher concentrations in the millimolar range confirm the interactions existing between the complex components. These data are considered to aid in removing previous objections to a mechanism of antimalarial action involving complexes of FP with AD and related drugs.
authors.affiliation: Department of Biological Chemistry, Hebrew University of Jerusalem, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Blauer
authors.forename: M
authors.initials: M
authors.lastname: Akkawi
authors.forename: E R
authors.initials: ER
authors.lastname: Bauminger
mesh_terms: D000655:Amodiaquine / Q000737:chemistry*; D004347:Drug Interactions; D006427:Hemin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015204:Spectroscopy, Mossbauer; D013696:Temperature
chemical_list: D000655:Amodiaquine; D006427:Hemin