title: Immune regulation: learning from leprosy.
abstract: The specific anergy seen in severe, disseminated leprosy appears to represent multifaceted actions of macrophages and suppressor T lymphocytes. Identification of cytokine mediation in these events helps to account for the immune system's "choice" of cellular versus humoral defenses--and points toward manipulation of cytokine switches for immunotherapy against infectious and autoimmune disease.
authors.affiliation: Division of Dermatology, University of California, Los Angeles, School of Medicine.
authors.forename: R L
authors.initials: RL
authors.lastname: Modlin
authors.forename: B R
authors.initials: BR
authors.lastname: Bloom
mesh_terms: D016207:Cytokines / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D015440:Leprosy, Lepromatous / Q000276:immunology*; D015441:Leprosy, Tuberculoid / Q000276:immunology* / Q000473:pathology; D009166:Mycobacterium leprae / Q000276:immunology; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016207:Cytokines