The role of the immune system in establishment of herpes simplex virus latency--studies using CD4+ T-cell depleted mice.
The immunological mechanisms involved in establishment of herpes simplex virus (HSV) latency were studied in normal and CD4+ T-cell depleted C57BL/6J mice following intravaginal infection. During transition from acute to latent ganglionic infection two consecutive processes were observed: first, clearance of infectious virus from the ganglia, and second, reduction of the number of infected ganglia.
Schmidt
D S
DS
Institute of Medical Microbiology and Immunology, University of Bonn, Federal Republic of Germany.
Eis-Hübinger
A M
AM
Schneweis
K E
KE
D000818:Animals; D005260:Female; D005724:Ganglia / Q000382:microbiology; D006561:Herpes Simplex / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018139:Simplexvirus / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D017735:Virus Latency / Q000276:immunology*