Cytotoxicity of Hymenocallis expansa alkaloids.
From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.
Antoun
M D
MD
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
Mendoza
N T
NT
Ríos
Y R
YR
Proctor
G R
GR
Wickramaratne
D B
DB
Pezzuto
J M
JM
Kinghorn
A D
AD
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D047151:Amaryllidaceae Alkaloids; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D051379:Mice; D010617:Phenanthridines; D010946:Plants, Medicinal / Q000737:chemistry*; D011647:Puerto Rico; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010617:Phenanthridines; C083906:hemanthidine; C060577:hippeastrine; C011361:tazettine