t(8;21) prior to acute leukemia.
A t(8;21)(q22;q22) without blood and bone marrow invasion by immature myeloid precursor cells occurred in a patient previously treated for polycythemia vera. The presence of a molecular rearrangement confirmed that the chromosomal abnormality was identical to that observed in acute leukemia with t(8;21). This case shows that the translocation, t(8;21), may occur in myelodysplasia and suggests that it can precede the appearance of overt leukemia.
Berger
R
R
INSERM U 301, Paris, France.
Hillion
J
J
Janvier
D
D
Chen
Z
Z
Bussel
A
A
D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D007964:Leukocytosis / Q000209:etiology / Q000235:genetics; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D011289:Preleukemia / Q000209:etiology / Q000235:genetics; D014178:Translocation, Genetic
D006918:Hydroxyurea