title: Estimation of infarct size using serum troponin T concentration in patients with acute myocardial infarction.
abstract: To estimate the size of myocardial infarction, serum troponin T concentration was measured in 34 patients with acute myocardial infarction. Left ventriculography, 2-dimensional echocardiography and resting 201thallium myocardial single photon emission computed tomography (SPECT) were performed about 4 weeks after the onset of myocardial infarction and used for correlation with the late serum troponin T peak concentration which occurred on the 3rd to 5th day after onset. Both left ventricular ejection fraction (LVEF) obtained from left ventriculography and wall motion index (WMI) obtained from 2-dimensional echocardiography were inversely related to late troponin T peak value (LVEF: r = 0.68, p < 0.001, WMI: r = 0.70, p < 0.001). Extent score (ES) and severity score (SS), which were estimated from the initial resting 201thallium SPECT image, showed excellent linear correlations with late troponin T peak concentrations (ES: r = 0.77, p < 0.001, SS: r = 0.66, p < 0.001). This correlation was present both in patients with an early troponin T peak on day 1 (group A-16 patients) and in those without an early peak (group B-10 patients). Thus, late troponin T peak concentration can be used to predict infarct size regardless of the kinetics of its appearance in serum.
authors.affiliation: Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Omura
authors.forename: M
authors.initials: M
authors.lastname: Teragaki
authors.forename: T
authors.initials: T
authors.lastname: Tani
authors.forename: H
authors.initials: H
authors.lastname: Yamagishi
authors.forename: S
authors.initials: S
authors.lastname: Yanagi
authors.forename: T
authors.initials: T
authors.lastname: Nishikimi
authors.forename: M
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: I
authors.initials: I
authors.lastname: Toda
authors.forename: K
authors.initials: K
authors.lastname: Akioka
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D011859:Radiography; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D014336:Troponin / Q000097:blood*; D020107:Troponin T
chemical_list: D013794:Thallium Radioisotopes; D014336:Troponin; D020107:Troponin T