The relationship between cytosolic free [Ca2+]i concentration and intracellular cAMP of platelet at various stages of experimental atherosclerosis in rabbits.
The relationship between cytosolic free [Ca2+]i and intracellular cAMP of platelet at various stages of experimental atherosclerosis in rabbits was studied. The results showed that the increase of [Ca2+]i was negatively correlated with the level of cAMP in cholesterol-fed rabbits (r = -0.667, P < 0.001) for 2, 4, 8 and 12 weeks. The viscosity of the whole blood at shear rates of 230.4/s and 5.76/s increased only in rabbits fed with cholesterol for 2 weeks, but the plasma viscosity increased in those fed for 2 and 4 weeks.
He
Z Y
ZY
Department of Hemorheology, Xinqiao Hospital, Third Military Medical College of PLA, Chongqing.
Li
X K
XK
Yu
X J
XJ
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology; D001792:Blood Platelets / Q000378:metabolism*; D001809:Blood Viscosity; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D007424:Intracellular Fluid / Q000378:metabolism; D008297:Male; D011817:Rabbits
D002791:Cholesterol, Dietary; D000242:Cyclic AMP; D000252:Calcium-Transporting ATPases; D002118:Calcium