Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex.
Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected control subjects (11 with other central nervous system (CNS) infections and four without CNS infection). In this study levels of sTNFR-p55, sTNFR-p75 and sCD25 were elevated in the CSF of ADC patients and of the 11 patients with other CNS infections, whereas CSF-levels of the specific T cell marker sCD27 were lower in patients with ADC as compared to the control subjects with and without other CNS infections. This pattern suggests a relative failure of eliciting a T cell-mediated immune response intrathecally in patients with ADC.
Portegies
P
P
Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.
Godfried
M H
MH
Hintzen
R Q
RQ
Stam
J
J
van der Poll
T
T
Bakker
M
M
van Deventer
S J
SJ
van Lier
R A
RA
Goudsmit
J
J
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid*; D015658:HIV Infections / Q000134:cerebrospinal fluid; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology; D016176:T-Lymphocyte Subsets; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000134:cerebrospinal fluid*
D015375:Receptors, Interleukin-2; D018124:Receptors, Tumor Necrosis Factor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7