Congenital cytomegalovirus infection presenting as cerebral ventriculomegaly on antenatal sonography.
Antenatal sonography in two cases demonstrated cerebral ventriculomegaly and decreased head circumference, subsequently found to be secondary to cytomegalovirus (CMV) infection. In both cases, the lateral ventricles were enlarged and lissencephaly was diagnosed in the neonatal period. The findings of ventriculomegaly and decreased head circumference on antenatal sonography warrant further investigation for CMV via amniotic fluid cultures or fetal blood, given the poor prognosis in infants with symptomatic infection.
Twickler
D M
DM
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032.
Perlman
J
J
Maberry
M C
MC
D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000151:congenital* / Q000000981:diagnostic imaging / Q000473:pathology; D002552:Cerebral Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal; D014556:Urine / Q000382:microbiology