title: [Recent information about the etiopathogenesis of paretic-paralytic forms of herpesvirus infection in horses].
abstract: From spring 1990 to summer 1991 we investigated 21 horses with clinical symptoms of EHV-infection by means of serological and virological methods including DNA-hybridization to identify the causative agents. The results indicated that, as already reported by us, EHV4 may also cause the paralytic form of the infection. The possibility of double infection with EHV4 and EHV1 cannot be excluded. In 3 out of 21 affected horses we could investigate brain tissue and/or spinal fluid by Dotblot hybridization with EHV1 and EHV4-DNA. The investigated samples of all three horses showed hybridization with EHV4-DNA, without or with less pronounced reaction with EHV1-DNA. The results were confirmed by serological investigation. Brain tissue and cerebrospinal fluid from two horses with paretic or paralytic disorders (1979 and 1980) was also investigated by DNA hybridization. In the liquor of one horse--a 5-month-old foal with neonatal ataxia--we detected EHV1-DNA. The other horse showed a strong reaction with EHV1 and a weaker reaction with EHV4 in its brain material and no hybridisation in the cerebrospinal fluid. The results are discussed.
authors.affiliation: Lehrstuhl für Mikrobiologie und Seuchenlehre, Tierärztlichen Fakultät München.
authors.forename: P
authors.initials: P
authors.lastname: Thein
authors.forename: G
authors.initials: G
authors.lastname: Darai
authors.forename: W
authors.initials: W
authors.lastname: Janssen
authors.forename: R D
authors.initials: RD
authors.lastname: Bergle
authors.forename: W
authors.initials: W
authors.lastname: Strube
authors.forename: G
authors.initials: G
authors.lastname: Floss
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000382:microbiology; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D006564:Herpesviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000150:complications / Q000382:microbiology / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006734:Horse Diseases / Q000209:etiology* / Q000382:microbiology; D006736:Horses; D008297:Male; D009693:Nucleic Acid Hybridization; D010243:Paralysis / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral
vernacular_title: Neuere Erkenntnisse zur Atiopathogenese der paretisch-paralytischen Verlaufsform der Herpesvirusinfektion des Pferdes.