Critical appraisal of immunization strategies for prevention of infection in the compromised host.
Chemotherapy and/or bone marrow transplantation clearly places individuals at increased risk for many vaccine-preventable diseases. Both active and passive immunization strategies have been considered for protecting immunocompromised patients. Many compromised hosts are capable of mounting protective responses to some protein toxoids, polysaccharide-conjugate, and viral vaccines. Effective, safe, and practical dosage schedules are evolving for individual vaccines and specific patient populations.
Ambrosino
D M
DM
Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts.
Molrine
D C
DC
D000917:Antibody Formation; D016026:Bone Marrow Transplantation / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D007116:Immunization, Passive; D016867:Immunocompromised Host; D007239:Infections / Q000276:immunology*; D009369:Neoplasms / Q000188:drug therapy