Levo-praziquantel versus praziquantel in experimental and clinical treatment of schistosomiasis japonica.
Levo-praziquantel is the left isomer of racemic praziquantel. Animal experiments showed that it is an active component of schistosomicidal activity, while dextro-praziquantel is almost ineffective. Clinical trials in three endemic areas of Schistosomiasis japonica indicated that the therapeutic efficacy of levo-praziquantel is superior to racemic praziquantel. Pharmacokinetic and pharmacodynamic activities of the stereoselectivity of praziquantel isomers (enantiomers) are discussed.
Liu
Y H
YH
Institute of Infections and Parasitic Diseases, Chong-qing University of Medical Sciences.
Qian
M X
MX
Wang
X G
XG
Quan
Y Z
YZ
Yan
S H
SH
Chen
B Y
BY
Li
J S
JS
Qiu
Z Y
ZY
D000818:Animals; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use* / Q000633:toxicity; D011817:Rabbits; D012554:Schistosomiasis japonica / Q000188:drug therapy*; D013237:Stereoisomerism
D011223:Praziquantel