title: Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy.
abstract: Tachyarrhythmias which originate above the bifurcation of the bundle of His or incorporate tissue proximal to it are classified as supraventricular tachyarrhythmias (SVT). Primary treatment of SVT attempts to influence the underlying disease. Therapy is subdivided into drug therapy, electrotherapeutic tools (e.g. antitachycardia pacemakers, catheter ablation) and antiarrhythmic surgery. Antiarrhythmic agents which slow conduction and suppress premature beats are efficient for emergency and long-term treatment of supraventricular tachycardias. We evaluated some of the most relevant antiarrhythmic drugs for SVT including propafenone, diprafenone, cibenzoline, lorcainide and sotalol; in addition, usage and efficacy of quinidine/verapamil, disopyramide, amiodarone, ajmaline, adenosine and flecainide are summarized. The principles for acute management of tachycardia episodes with narrow and broad complexes are outlined. The reason for the selection as well as the efficacy in the termination of the tachycardias is described for different antiarrhythmic agents including verapamil, adenosine, ajmaline, propafenone and flecainide.
authors.affiliation: Department of Internal Medicine-Cardiology, University of Bonn, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Manz
authors.forename: B
authors.initials: B
authors.lastname: Lüderitz
mesh_terms: D000404:Ajmaline / Q000627:therapeutic use; D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy; D001282:Atrial Flutter / Q000188:drug therapy; D004206:Disopyramide / Q000627:therapeutic use; D005424:Flecainide / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D011226:Pre-Excitation Syndromes / Q000188:drug therapy*; D011405:Propafenone / Q000031:analogs & derivatives / Q000627:therapeutic use; D011802:Quinidine / Q000627:therapeutic use; D013015:Sotalol / Q000627:therapeutic use; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; C047546:diprafenone; D000404:Ajmaline; D011405:Propafenone; D013015:Sotalol; D014700:Verapamil; D004206:Disopyramide; D011802:Quinidine; D005424:Flecainide; D000638:Amiodarone; C032151:cifenline