title: Histamine-containing nerve fibers innervate human cerebellum.
abstract: Histamine is found in nerve cell bodies of the tuberomammillary nucleus in mammalian brain. This nucleus is prominent in human brain. Samples of human cerebelli obtained from neurosurgical operations were examined for the presence of histamine-containing nerve fibers. In all samples, a moderately dense network of histamine-immunoreactive fibers was seen in the molecular layer. These fibers ran parallel to the Purkinje cell layer after traversing it perpendicularly. Numerous fibers were also seen in the granular cell layer. The results suggest that the human cerebellar cortex receives a direct input from histamine-synthesizing hypothalamic neurons, as no other histamine-containing neurons have been found in human brain.
authors.affiliation: Department of Biology, Abo Akademi University, Biocity, Turku, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Panula
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: N
authors.initials: N
authors.lastname: Inagaki
authors.forename: A
authors.initials: A
authors.lastname: Yamatodani
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: E
authors.initials: E
authors.lastname: Kotilainen
mesh_terms: D000368:Aged; D002525:Cerebellar Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002531:Cerebellum / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D005456:Fluorescent Dyes; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000378:metabolism*; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D011969:Receptors, Histamine H1 / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D012701:Serotonin; D006632:Histamine