title: Treatment of endometrial carcinoma with radiation therapy alone.
abstract: OBJECTIVE
  To review the results of treatment with radiotherapy alone in 152 patients with adenocarcinoma of the endometrium who had medical or surgical contraindications to hysterectomy.
  
  
  METHODS
  We reviewed the records of all patients who were treated with radiotherapy alone for uterine carcinoma at The University of Texas M. D. Anderson Cancer Center between 1960 and 1986. One hundred fifty-two cases were analyzed. Most patients had multiple medical problems. One hundred sixteen patients were treated with intracavitary radiotherapy alone. A combination of external beam and intracavitary radiotherapy was used for 10 patients with Stage I disease who had unusually large cavities, 10 patients with Stage II disease, and 13 of 15 patients with Stage III or IV disease. Histologic material was reviewed in 91 cases.
  
  
  RESULTS
  Ten years after treatment, these patients were twice as likely to have died of intercurrent illness as of uterine cancer. The 5-year disease-specific survival rate of patients with Stage I disease was 87%. The disease-specific survival of patients with Stage II disease was 88%, which was not significantly different from that of Stage I patients. Stage III and IV patients had a significantly poorer disease-specific survival rate of 49% at 5 years. Intrauterine recurrence occurred in 14% of the patients with Stage I or II disease. Salvage treatment was attempted in 5 of the 10 patients who had isolated intrauterine recurrences of Stage I disease and was successful in all cases. Extrauterine pelvic recurrence developed in only 3% of Stage I and II patients. Of 82 Stage I and II carcinomas that were available for pathologic review, 17 (21%) were clear-cell or papillary serous variants. The disease-specific survival rate of patients with Stage I or II papillary serous carcinomas was 43%, significantly poorer than that of patients with endometrioid carcinomas. Seven patients experienced acute anesthesia-related complications; none were fatal. Five patients had serious late complications of radiation therapy.
  
  
  CONCLUSIONS
  Radical radiotherapy achieved acceptable DSS and local control rates in patients with medically or surgically inoperable uterine carcinoma. However for patients with localized disease, such treatment is justified only when the operative risk exceeds the 10-15% uterine recurrence rate expected with radiation alone.
authors.affiliation: Division of Radiotherapy, University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: P A
authors.initials: PA
authors.lastname: Kupelian
authors.forename: P J
authors.initials: PJ
authors.lastname: Eifel
authors.forename: C
authors.initials: C
authors.lastname: Tornos
authors.forename: T W
authors.initials: TW
authors.lastname: Burke
authors.forename: L
authors.initials: L
authors.lastname: Delclos
authors.forename: M J
authors.initials: MJ
authors.lastname: Oswald
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000532:radiotherapy*; D001918:Brachytherapy / Q000009:adverse effects; D000075202:Contraindications; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate