title: Drainage of the gallbladder in patients with acute acalculous cholecystitis by transpapillary endoscopic cholecystotomy.
abstract: The mortality associated with acute acalculous cholecystitis approaches 50%. Removal or decompression of the gallbladder in these patients may prevent gallbladder rupture and may be lifesaving. This is usually accomplished by cholecystectomy, cholecystotomy, or percutaneous gallbladder drainage. We describe a novel transpapillary endoscopic approach to gallbladder drainage in patients at high surgical risk. A total of seven high surgical risk patients were treated with transpapillary endoscopic cholecystotomy. Cannulation of the cystic duct was accomplished by using standard hourglass-tipped catheters in two patients. A new "selector" catheter was developed for selective cannulation of the cystic duct and used in the other five patients. Five of the seven patients showed evidence of clinical, radiographic, and laboratory improvement after treatment. We conclude that transpapillary endoscopic cholecystotomy may be an effective treatment alternative for high surgical risk patients with acalculous cholecystitis.
authors.affiliation: Clifton Center for Digestive Diseases, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City 52242.
authors.forename: F C
authors.initials: FC
authors.lastname: Johlin
authors.forename: G A
authors.initials: GA
authors.lastname: Neil
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage; D000208:Acute Disease; D000328:Adult; D000368:Aged; D002404:Catheterization / Q000295:instrumentation; D002764:Cholecystitis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D004322:Drainage / Q000379:methods*; D004867:Equipment Design; D005260:Female; D005704:Gallbladder; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016717:Sphincterotomy, Endoscopic; D007507:Therapeutic Irrigation / Q000379:methods
chemical_list: D000111:Acetylcysteine