[Ras oncogene expression of left ventricle in hypertrophic rat heart and during induction by vasopressin and neosynephrine].
Using molecular hybridization, left ventricular ras oncogene expression was examined in the hypertrophic heart of rat or during injection of vasopressin or alpha-receptor agonist neosynephrine. Results showed that ras oncogene expression of left ventricle could be potentiated by neosynephrine but not by vasopressin. Furthermore, expression of both nucleic oncogene myc and membrane oncogene ras were increased during chronic cardiac pressure overload, with the former occurring in early loading stage and the latter staying the whole loading stage.
Xu
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Laboratory of Cardiovascular Molecular Biology and Cardiopulmonary Endocrinology, Beijing Medical University.
D000818:Animals; D015870:Gene Expression / Q000187:drug effects*; D016259:Genes, myc; D011905:Genes, ras; D017379:Hypertrophy, Left Ventricular / Q000235:genetics*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014667:Vasopressins / Q000494:pharmacology*
D012333:RNA, Messenger; D014667:Vasopressins; D010656:Phenylephrine