Protein C and S deficiency causing childhood stroke.
The annual incidence of cerebrovascular disease in children is 2.5/100,000 and cerebral infarction is being increasingly recognised in neonates. Deficiency of proteins C and S and their roles in thrombosis have only recently been recognised. Immunologic and functional assays of these proteins now make it possible to determine whether deficiency of them is associated in any particular case of childhood cerebrovascular accident (CVA). We describe two patients, both presenting with stroke in childhood, who were found to be deficient, one in protein C and one in protein S.
Brown
D C
DC
Royal Hospital for Sick Children, Edinburgh.
Livingston
J H
JH
Minns
R A
RA
Eden
O B
OB
D002561:Cerebrovascular Disorders / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D020151:Protein C Deficiency; D018455:Protein S Deficiency