[The suppressive effect of Tripterygium wilfordii hook F on the IL-2 autocrine loop of human T cells].
We studied the effect of Tripterygium wilfordii Hook F on the IL-2 autocrine loop of human T cells in vitro. The results revealed that GTW significantly inhibited the activation of T cells production of IL-2, expression of IL-2R and proliferation response of activated T cells exogenous IL-2.
Dong
Y
Y
PUMC Hospital, Beijing.
D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D015375:Receptors, Interleukin-2