Histomorphological studies on the effect of recombinant human superoxide dismutase in biochemically induced osteoarthritis.
Enzymatic scavenging of .O-2 radicals by injections of superoxide dismutase has been described to inhibit the free radical reactions resulting in tissue damage. Using a biochemically induced model of osteoarthritis (OA) in the knee joints of hens, we investigated the histomorphological alterations under therapy with recombinant human superoxide dismutase (rH-SOD) in various doses by histological-histochemical grading. Treatment of experimental OA with rH-SOD (0.1 mg/0.1 ml intra-articularly) led to a significant reduction in the intensity of cartilage degradation. The pathomorphological alterations in the osteoarthritic cartilage of hens treated with rH-SOD were quantitatively but not qualitatively different from the placebo-treated group. Our results indicate that rH-SOD exerts an inhibitory effect on the deleterious processes on articular cartilage tissue during the course of OA and may counteract cartilage degradations induced or accelerated by oxygen radicals.
Hoedt-Schmidt
S
S
Institute of Pharmacology and Toxicology, University of Bonn, FRG.
Schneider
B
B
Kalbhen
D A
DA
D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology; D002645:Chickens; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007461:Iodoacetates / Q000633:toxicity; D019807:Iodoacetic Acid; D007719:Knee Joint / Q000187:drug effects / Q000473:pathology; D010003:Osteoarthritis / Q000139:chemically induced* / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D007461:Iodoacetates; D013482:Superoxide Dismutase; D019807:Iodoacetic Acid