title: Bronchodilator reversal of bronchospasm and symptoms incurred during methacholine bronchoprovocation challenge. Documentation of safety and time course.
abstract: We undertook a prospective study of bronchoprovocation challenge (BPC) to look at issues of safety and reversibility of bronchospasm and symptoms induced by BPC. Over a 14-month interval, we documented 62 consecutive cases of bronchial hyperresponsiveness. During BPC, there was a statistically significant but clinically modest increase in both cough and dyspnea. Both bronchospasm and symptoms were readily reversed with a simple protocol of inhaled albuterol using a metered-dose inhaler with a spacer. Routine protocol was effective in every case; there was never a need for individualized physician intervention. Our prospective data document the safety of BPC; we could find no reason why BPC would need to be confined to the hospital. We conclude that BPC is a valuable clinical test which merits wider dissemination and use.
authors.affiliation: Department of Medicine, Robert Wood Johnson School of Medicine, Cooper Hospital/University Medical Center, Camden, NJ.
authors.forename: M R
authors.initials: MR
authors.lastname: Pratter
authors.forename: T C
authors.initials: TC
authors.lastname: Bartter
authors.forename: J
authors.initials: J
authors.lastname: Dubois
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001985:Bronchial Provocation Tests / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy* / Q000453:epidemiology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002648:Child; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology; D004417:Dyspnea / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology; D005069:Evaluation Studies as Topic; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000009:adverse effects*; D008875:Middle Aged; D011446:Prospective Studies; D012449:Safety; D013147:Spirometry; D013997:Time Factors
chemical_list: D001993:Bronchodilator Agents; D016210:Methacholine Chloride