title: The effect of clindamycin gel insert in periodontal pockets, as observed on smears and cultures.
abstract: This study is aimed at the evaluation of a 1% clindamycin hydrochloride containing gel on the microbial flora of periodontal pockets deeper than 5 mm. In order to achieve that purpose, 20 patients with pocketing in the premolar-molar regions were selected. Active and placebo gel were inserted once during the first 2 weeks of this experimental study. Microbial samplings were performed 1, 2, 4 and 12 weeks after the experiment started. The samples were submitted to microscopic examination and also to culture. Changes in the microbial content of the periodontal pockets treated by subgingival scaling and clindamycin 1% gel were significant, compared with those obtained with subgingival scaling and placebo gel, particularly with respect to anaerobic black-pigmented bacteria and the motile gram-negative flora. However, after 3 months, most of the treated cases were recolonized by the same initial species, though never at pre-clindamycin levels. In the light of this study, it will be concluded that the use of a small amount of clindamycin hydrochloride inserted into a periodontal pocket, once a week for 2 weeks as a complement to periodontal subgingival scaling, is beneficial in the treatment of adult periodontitis, by eliminating more effectively the microbial pocket colonization.
authors.affiliation: Dept. of Clinical Microbiology, Brugmann University Hospital, Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Sauvêtre
authors.forename: Y
authors.initials: Y
authors.lastname: Glupczynsky
authors.forename: M
authors.initials: M
authors.lastname: Labbé
authors.forename: E
authors.initials: E
authors.lastname: Yourassowsky
authors.forename: M
authors.initials: M
authors.lastname: Pourtois
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002908:Chronic Disease; D002981:Clindamycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology; D005260:Female; D005782:Gels; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000382:microbiology*; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D005782:Gels; D002981:Clindamycin