Oral cancer: new insights into pathogenesis.
Understanding the pathogenesis of cancer may well lead to improved diagnostic tests, preventive treatment and management. This paper reviews the gene changes, the evidence implicating viruses in the aetiology of oral cancer, and the mechanisms whereby viruses may affect gene function and thereby contribute to carcinogenesis.
Scully
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Department of Oral Medicine, Pathology and Microbiology, University of Bristol Dental Hospital and School, UK.
D002471:Cell Transformation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics* / Q000382:microbiology*; D009857:Oncogenes; D027383:Papillomaviridae / Q000472:pathogenicity; D018139:Simplexvirus / Q000472:pathogenicity