Sodium diclofenac inhibits hyperthermia induced by paradoxical sleep deprivation: the possible participation of prostaglandins.
Sodium diclofenac inhibits hyperthermia induced by paradoxical sleep deprivation (PSD), which suggests the participation of prostaglandins. The temperature of paradoxical sleep-deprived rats increased from the first to the fourth day of deprivation. This hyperthermia was blocked on the second, third, and fourth days by daily administration, twice a day, of 10 mg/kg of sodium diclofenac, a potent prostaglandin synthesis inhibitor. In the dose of 10 mg/kg, a decrease of temperature was observed only on the second and third days of PSD. These data suggest the participation of prostaglandins in modulating the increase in temperature during PSD.
Seabra
M de L
Mde L
Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brasil.
Tufik
S
S
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D004008:Diclofenac / Q000494:pharmacology*; D007375:Interleukin-1 / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology
D007375:Interleukin-1; D011453:Prostaglandins; D004008:Diclofenac