title: [Hypothalamic syndromes. Review of clinical and endocrinal semiology].
abstract: A case of hypothalamic dysfunction in a girl with a twelve-year follow-up is reported. Onset occurred at the age of three with severe obesity, hypothermia, hypersomnia, and lethargy. Somatotropic, gonadotropic, and thyrotropic hormones were low, whereas prolactin was increased. Imaging techniques failed to disclose any lesion of the hypothalamus or pituitary. Clomipramine improved the vegetative disorders. The literature on clinical and hormonal disorders of hypothalamic dysfunction is reviewed.
authors.affiliation: Service de Pédiatrie B, Centre Robert Debré, CHU, Angers.
authors.forename: M G
authors.initials: MG
authors.lastname: Joseph
authors.forename: A C
authors.initials: AC
authors.lastname: Jouanny
authors.forename: F
authors.initials: F
authors.lastname: Chomienne
authors.forename: G
authors.initials: G
authors.lastname: Champion
authors.forename: J L
authors.initials: JL
authors.lastname: Giniès
authors.forename: J M
authors.initials: JM
authors.lastname: Limal
mesh_terms: D002675:Child, Preschool; D002997:Clomipramine / Q000627:therapeutic use; D006970:Disorders of Excessive Somnolence / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006062:Gonadotropins / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007027:Hypothalamic Diseases / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D007035:Hypothermia / Q000209:etiology*; D009765:Obesity / Q000209:etiology*; D011388:Prolactin / Q000097:blood; D012894:Sleep Stages / Q000502:physiology*; D013577:Syndrome; D013972:Thyrotropin / Q000097:blood
chemical_list: D006062:Gonadotropins; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D002997:Clomipramine
vernacular_title: Syndromes hypothalamiques. Revue de la sémiologie clinique et endocrinienne.