title: [Effectiveness and safety of 150 mg vs 300 mg ranitidine twice a day in duodenal ulcer].
abstract: 394 patients with endoscopically diagnosed duodenal ulcer were randomly allocated to treatment with ranitidine 150 bid o ranitidine 300 mg bid in a prospective double-blind multicenter trial conducted in seven LatinoAmerican countries. Endoscopy at 4 weeks showed complete ulcer healing en 171 of 196 patients (87.2%) treated with ranitidine 150 mg bid and 178 of 198 (89.9%) treated with ranitidine 300 mg bid. Both treatment regimens were equally effective at rapidly reducing the incidence of ulcer-related symptoms. It is possible that higher dosage regimen of ranitidine would be useful in patients with more severe duodenal ulcer disease.
authors.forename: M
authors.initials: M
authors.lastname: Schraier
authors.forename: A
authors.initials: A
authors.lastname: Jorge
authors.forename: J C
authors.initials: JC
authors.lastname: Pereyra
authors.forename: J
authors.initials: J
authors.lastname: Carri
authors.forename: M
authors.initials: M
authors.lastname: Padua-Videla
authors.forename: P
authors.initials: P
authors.lastname: Hoffenberg
authors.forename: J
authors.initials: J
authors.lastname: Villalobos
authors.forename: J
authors.initials: J
authors.lastname: Orillac
authors.forename: M
authors.initials: M
authors.lastname: Waserstein
authors.forename: S
authors.initials: S
authors.lastname: Mendoza
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010176:Panama; D011899:Ranitidine / Q000008:administration & dosage*; D013020:South America
chemical_list: D011899:Ranitidine
vernacular_title: Eficacia y seguridad de Ranitidina 150 mg vs 300 mg dos veces por día en ulcera duodenal.