title: Progressive encephalopathy associated with cytomegalovirus infection without immune deficiency.
abstract: Slowly progressive encephalopathy caused by cytomegalovirus is an unusual disorder, and its pathogenesis remains unknown except for cases associated with the acquired immune deficiency syndrome and organ transplantation. We report a case who showed clinical features of progressive encephalopathy. Cytomegalovirus was repeatedly isolated from urine, and cytomegalovirus-infected cells were detected in bone marrow. Serial computed tomographic head scan revealed periventricular calcification and its progression to the thalamus, cerebellum, and brain stem. On autopsy, there were multiple calcifications and diffuse glial proliferation in the gray and white matter. Perivascular inflammation was only minimal. There was no evidence of immune deficiency. This case suggests that progressive encephalopathy can be caused by cytomegalovirus infection without immune deficiency. This type of cytomegalovirus infection may be unusual, but its serious outcome should remind us to detect it accurately.
authors.affiliation: Division of Child Neurology, Tottori University School of Medicine, Yonago, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Koeda
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: H
authors.initials: H
authors.lastname: Kawahara
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: Y
authors.initials: Y
authors.lastname: Eizuru
authors.forename: T
authors.initials: T
authors.lastname: Minematsu
authors.forename: Y
authors.initials: Y
authors.lastname: Minamishima
mesh_terms: D001921:Brain / Q000503:physiopathology*; D002114:Calcinosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology*; D007075:Immunoglobulin M / Q000502:physiology*; D016272:Occupational Health; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M