Dentin formation in miniature pigs with special reference to indomethacin and orthodontic treatment.
The rate of dentin mineralization and the influence of indomethacin on the dentin mineralization rate during orthodontic treatment was determined in miniature pigs by intravital labeling with tetracycline. The results demonstrated that the dentin mineralization rate in the control animals was 3.8 microns/day, a rate corresponding to that of human teeth. Both indomethacin and orthodontics had an effect on the dentin mineralization rate, indomethacin reducing and orthodontic forces increasing it. In combination, the two factors neutralized each other.
Giunta
D
D
Orthodontic Department, II Dentistry School, University of Naples, Italy.
Keller
J
J
Nielsen
F F
FF
Melsen
B
B
D000818:Animals; D003804:Dentin / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D003810:Dentinogenesis / Q000187:drug effects* / Q000502:physiology*; D005453:Fluorescence; D007180:Incisor; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D009967:Orthodontic Appliances; D013314:Stress, Mechanical; D013552:Swine; D013556:Swine, Miniature; D013752:Tetracycline; D014074:Tooth Calcification / Q000187:drug effects / Q000502:physiology
D013752:Tetracycline; D007213:Indomethacin