[Mitotic index of intraepithelial lymphocytes in children with celiac disease. Retrospective study].
The mitotic activity of epithelial lymphocytes was determined in 69 jejunal biopsies performed in 23 children with celiac disease. The mitotic index (MI) exceeded 0.2% in 46 biopsies obtained in untreated celiac and during acute gluten challenge. In the 23 biopsies made during the period of gluten restriction the mitotic index fell down under 0.2%. This retrospective study confirm the reproducibility of the method proposed by Marsh. The high mitotic index in the first biopsy may be useful to reduce in the future the multiple biopsies currently necessary for the diagnosing celiac disease.
García de Dávila
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MT
Servicio de Patología, Hospital Nacional de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
De Rosa
S
S
D002446:Celiac Disease / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007422:Intestines / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008940:Mitotic Index; D011897:Random Allocation; D015203:Reproducibility of Results; D012189:Retrospective Studies
Indice mitótico de linfocitos intraepiteliales en niños con enfermedad celíaca. Estudio retrospectivo.