Synthesis and biological properties of 5-hydroxy-methylpyrimidines.
Reduction of 4-arylamine-6-methyl-2-phenyl-5-pyrimidine carboxylic acid and its ethyl esters as well as 5,7-dihydrofuro (3,4-d)-pyrimidines resulted in obtaining some 4-arylamine-6-methyl-2-phenyl-5-hydroxymethylpyrimidines exhibiting strong immunomodulatory and cytostatic properties.
Cieplik
J
J
Organic Chemistry Department, Medical Academy, Wrocław, Poland.
Machoń
Z
Z
Zimecki
M
M
Wieczorek
Z
Z
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D011743:Pyrimidines