Food intake, sympathetic activity, and adrenal steroids.
Food Intake is reciprocally related to the activity of sympathetic nerves to brown adipose tissue. This reciprocal or feedback relation is shown for hypothalamic lesions, drugs, and many peptides. These peptides also modulate intake of specific nutrients. Galanin and opioids increase fat intake, whereas enterostatin decreases fat intake. NPY increases carbohydrate intake and growth hormone releasing hormone decreases protein intake. The activity of the sympathetic nervous system is low in obesity and adrenalectomy reverses this decrease in sympathetic activity and reverses or stops the progression of obesity. One mechanism for this effect of adrenal steroids is through a transacting substance which is involved in steroid actions and the production of obesity.
Bray
G A
GA
Department of Medicine, Louisiana State University, School of Medicine, Baton Rouge 70808-4124.
D000311:Adrenal Glands / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D004435:Eating / Q000502:physiology*; D008969:Molecular Sequence Data; D009638:Norepinephrine / Q000378:metabolism; D009752:Nutritional Status / Q000502:physiology; D010455:Peptides / Q000502:physiology; D013256:Steroids / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D010455:Peptides; D013256:Steroids; D009638:Norepinephrine