title: The effects of World Health Organization chemotherapy on imported leprosy in Auckland, New Zealand, 1983-90.
abstract: Between January 1983 and December 1990 in Auckland, New Zealand, 87 patients (28 paucibacillary disease (PBD) and 59 multibacillary disease (MBD)) commenced WHO multidrug therapy (MDT). All were immigrants from the Pacific Islands (65) or Asia (22). A total of 57 patients had already received non-WHO regimens, some continuously, but often intermittently, for many years; 30 patients received WHO MDT only. By December 1990, 50 had completed treatment, with 1 relapse and 1 late reaction, both in patients with PBD treated with WHO MDT only. There have been no relapses in those treated with WHO MDT after prior leprosy treatment. In those with MBD, type II leprosy reactions were less common (16%) in those treated only with WHO MDT than in those treated continuously before 1983 with older regimens (64%). Type I leprosy reactions occurred in about 20% of both these groups. The bacterial index fell faster in those who had had a prolonged prior treatment beginning WHO MDT than in those starting WHO MDT as their initial leprosy chemotherapy. Overall we found WHO MDT was well accepted and the compliance good, but 13 patients (15%) left Auckland before treatment was completed and 6 (7%) during follow up.
authors.affiliation: Infectious Disease Unit, Auckland Hospital, New Zealand.
authors.forename: J
authors.initials: J
authors.lastname: Cornwall
authors.forename: G
authors.initials: G
authors.lastname: Cameron
authors.forename: R B
authors.initials: RB
authors.lastname: Ellis-Pegler
mesh_terms: D001208:Asia / Q000208:ethnology; D004359:Drug Therapy, Combination; D004641:Emigration and Immigration; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D009520:New Zealand; D010139:Pacific Islands / Q000208:ethnology; D014944:World Health Organization
chemical_list: D007917:Leprostatic Agents