[Hypotensive effect of neuropeptide Y in substantia nigra].
The central hypotensive effect of neuropeptide Y (NPY) has been investigated by microinjection of the peptide into substantia nigra (SN) of anesthetized normotensive rats. NPY microinjection into SN produced dose-dependent falls in arterial blood pressure but no change in heart rate statistically. Microinjection of cholecystokinin octapeptide or 0.9% saline into SN did not elicit prominent change in arterial blood pressure and heart rate. The results suggest that NPY in SN exerts a distinctive hypotensive effect in certain degree.
Yang
S N
SN
Norman Bethune University of Medical Sciences, Changchun.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D008297:Male; D008845:Microinjections; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology
D009478:Neuropeptide Y