title: [Chronic mucocutaneous herpes simplex infection. Occurrence within the scope of liver-induced immunodeficiency].
abstract: Herpes simplex virus (HSV) infections causing severe disease are reported frequently in patients suffering from human immunodeficiency virus (HIV) infection. This disease pattern may also be seen in an immunocompromised disease state with other causes, however, as in the case presented in this paper. An 84-year-old woman had hepatic cirrhosis resulting from chronic hepatitis C virus infection. The woman developed ulcerative lesions in and around her mouth and in the genito-anal region, and these persisted for some months. Diagnosis of HSV infection was not obtained until after extensive laboratory investigations. Aciclovir infusion therapy started immediately afterwards led to dramatic improvement of the skin and mucous membrane changes. Complete clearing of lesions was not obtained, however, because the patient died as a result of the immunosuppression.
authors.affiliation: Hautklinik, Universitäts-Krankenhaus Eppendorf, Hamburg.
authors.forename: D
authors.initials: D
authors.lastname: Abeck
authors.forename: O
authors.initials: O
authors.lastname: Brandt
authors.forename: M
authors.initials: M
authors.lastname: Weichenthal
authors.forename: L
authors.initials: L
authors.lastname: Kowalzick
authors.forename: H
authors.initials: H
authors.lastname: Mensing
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005455:Fluorescent Antibody Technique; D006526:Hepatitis C / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006558:Herpes Genitalis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006561:Herpes Simplex / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D009894:Opportunistic Infections / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000473:pathology; D013283:Stomatitis, Herpetic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
chemical_list: D000212:Acyclovir
vernacular_title: Chronische mukokutane Herpes-simplex-Infektion. Auftreten im Rahmen einer hepatisch bedingten Immundefizienz.