title: Leigh disease (subacute necrotizing encephalomyelopathy): MR documentation of the evolution of an acute attack.
abstract: The radiologic evolution of Leigh disease is documented with sequential brain MR in the acute phase of the illness, at 3 weeks, and at 3 months. High-signal-intensity lesions seen on T2-weighted images in the first week resolved by 3 months, whereas new lesions appear during the chronic stage. Putamenal involvement is not a pathognomonic radiologic finding. Brain stem tegmentum, particularly the mesencephalon, is characteristically involved on MR in the early and late phases of the illness.
authors.affiliation: Neurology Unit, Groote Schuur Hospital, Cape, South Africa.
authors.forename: J M
authors.initials: JM
authors.lastname: Heckmann
authors.forename: R
authors.initials: R
authors.lastname: Eastman
authors.forename: L
authors.initials: L
authors.lastname: Handler
authors.forename: M
authors.initials: M
authors.lastname: Wright
authors.forename: P
authors.initials: P
authors.lastname: Owen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007888:Leigh Disease / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging