[Erythroderma disclosing transformation of refractory anemia with excess of blasts into lymphoblastic leukemia].
We report a case of erythroderma revealing lymphoblastic leukaemia occurring immediately after myelodysplasia. The patient was an 87-year old man admitted for poor general condition, lymph node enlargement and pruriginous oedematous erythroderma. Laboratory examinations showed tricytopenia, bone marrow invasion by lymphoblasts in a myelodysplastic environment of the refractory anaemia type with excess of blasts, and a cutaneous lymphocytic infiltrate with non-blastic lymph node reaction. Owing to its morphological and immunohistological features, the lymphocytic infiltrate was regarded as non-specific. We could not help comparing this case to the other non-specific cutaneous lesions of refractory anaemia which usually reflect transformation into leukaemia.
Bodokh
I
I
Service de Dermatologie, Hôpital Pasteur, Nice.
Lacour
J P
JP
Perrin
C
C
Rosenthal
E
E
Garnier
G
G
Pesce
A
A
Ortonne
J P
JP
D000368:Aged; D000369:Aged, 80 and over; D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications*; D002471:Cell Transformation, Neoplastic; D003873:Dermatitis, Exfoliative / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
Erythrodermie révélatrice de la transformation d'une anémie réfractaire avec excès de blastes en leucémie lymphoblastique.