title: [An analysis of the prevalence of isolated dental anomalies and of those associated with hereditary syndromes: a model for evaluating the genetic control of the dentition characteristics].
abstract: Tooth ontogenesis, morphogenesis, and eruption are under a multifactorial (genetic, epigenetic, environmental) control. The aim of this study has been a genetic appraisal of tooth developmental characteristics by means of the prevalence and patterns of association of tooth anomalies in a large sample of hereditary syndromes. MATERIALS AND METHODS. A sample of 169 hereditary syndromes exhibiting tooth abnormalities was collected from the literature: original articles were controlled in order to achieve uniformity of judgement about the definition of the dental defects. Tooth anomalies were classified according to anatomoclinical criteria: number (hypodontia/hyperdontia), shape, position, structure (enamel/dentin/cementum), size (micro-/macrodontism), eruption (precocious/delayed including unerupted teeth). Prevalence data were calculated for: 1) modes of syndrome inheritance; 2) syndromes exhibiting a single dental anomaly vs. syndromes exhibiting associated tooth abnormalities; 3) different types of tooth abnormalities; 4) isolated and associated tooth abnormalities.
authors.affiliation: Istituto di Odonto-Gnato-Stomatologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Firenze.
authors.forename: T
authors.initials: T
authors.lastname: Baccetti
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000235:genetics; D002869:Chromosome Aberrations / Q000453:epidemiology / Q000235:genetics; D025063:Chromosome Disorders; D003817:Dentition; D006801:Humans; D008957:Models, Genetic; D015995:Prevalence; D013577:Syndrome; D014071:Tooth Abnormalities / Q000453:epidemiology* / Q000235:genetics*
vernacular_title: Analisi della prevalenza di anomalie dentali isolate ed associate nelle sindromi ereditarie: modello per la valutazione del controllo genetico sulle caratteristiche della dentatura.