Effects of food, ceruletide and ranitidine on the pharmacokinetics of the oral cephalosporin S-1108 in humans.
The pharmacokinetics of S-1108, an ester-type oral cephalosporin antibiotic, were studied in healthy male volunteers in a crossover study. This study focused especially on the effects on S-1108 absorption of (1) a meal, (2) concomitant administration of ceruletide diethylamine (a drug which promotes the secretion of bile) in the fasting state, and (3) concomitant administration of ranitidine hydrochloride (a drug which adjusts the acidity of the gastric juice) in the fasting state. The results show that the absorption of S-1108 after oral administration may be affected by factors such as food and ranitidine hydrochloride.
Saito
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College of Medical Technology, Hokkaido University, Sapporo, Japan.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002108:Ceruletide / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005215:Fasting / Q000378:metabolism; D005502:Food; D006801:Humans; D008297:Male; D011355:Prodrugs / Q000493:pharmacokinetics*; D011899:Ranitidine / Q000494:pharmacology*
D002511:Cephalosporins; D011355:Prodrugs; C076133:S 1108; D011899:Ranitidine; D002108:Ceruletide