Effect of lead on anorexia and body weight in albino rats.
Rats exposed to lead (lead acetate) in doses of 0.2 and 0.5 mg/ml in drinking water for a period of 90 days showed mild to moderate changes in food consumption compared to control group. Drug interactions in lead exposed rats with metoclopramide, atropine sulphate, propranolol, cyproheptadine and mepyramine maleate when administered intraperitoneally caused -30 to +30 percentage variation in food intake indicating the influence of adrenergic, serotonergic and cholinergic neurotransmitters with no change in mean body weight of lead treated rats.
Amin
R J
RJ
Department of Agricultural Health, National Institute of Occupational Health, Meghani Nagar, Ahmedabad.
Venkatakrishna-Bhatt
H
H
Panchal
G M
GM
D000284:Administration, Oral; D000818:Animals; D000855:Anorexia / Q000139:chemically induced* / Q000503:physiopathology; D001337:Autonomic Agents / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D001337:Autonomic Agents; D009942:Organometallic Compounds; C008261:lead acetate