title: Carcinoma in female urethral diverticulum: case reports and review of management.
abstract: We report on 4 women ages 31 to 65 years with adenocarcinoma of urethral diverticulum. One patient presented with metastatic disease and died after refusing post-radiation surgery. The other 3 women were without evidence of disease 9 to 44 months after diverticulectomy with radiation (1) or radical surgery (2). Review of our 4 cases and 64 cases documented in the literature showed that irritative voiding symptoms and hematuria were the most common findings. A palpable urethral mass was described in only 56% of reported cases but was observed in all of our patients, with the smallest mass measuring 2 x 2 cm. Urethroscopy with biopsy is the most important diagnostic test. Aggressive treatment is appropriate in most patients, since local recurrence has been documented in 44% of those treated by diverticulectomy and/or radiation.
authors.affiliation: Department of Urology, New York Medical College/Westchester County Medical Center, Valhalla.
authors.forename: N
authors.initials: N
authors.lastname: Rajan
authors.forename: P
authors.initials: P
authors.lastname: Tucci
authors.forename: C
authors.initials: C
authors.lastname: Mallouh
authors.forename: M
authors.initials: M
authors.lastname: Choudhury
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D000328:Adult; D000368:Aged; D004240:Diverticulum / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D014522:Urethral Diseases / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D014523:Urethral Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000628:therapy