Metabolism of triacetin-derived acetate in dogs.
Triacetin is a water-soluble triglyceride that may have a role as a parenteral nutrient. In the present study triacetin was administered intravenously to mongrel dogs (n = 10) 2 wk after surgical placement of blood-sampling catheters in the aorta and in the portal, hepatic, renal, and femoral veins. [1-14C]Acetate was infused to allow quantification of organ uptake of acetate as well as systemic turnover and oxidation. Systemic acetate turnover accounted for approximately 70% of triacetin-derived acetate, assuming complete hydrolysis of the triglyceride. Approximately 80% of systemic acetate uptake was rapidly oxidized. Significant acetate uptake was demonstrated in all tissues (liver, 559 +/- 68; intestine, 342 +/- 23; hindlimb, 89 +/- 7; and kidney, 330 +/- 37 mumol/min). In conclusion, during intravenous administration in dogs, the majority of infused triacetin undergoes intravascular hydrolysis, and the majority of the resulting acetate is oxidized. Thus, energy in the form of short-chain fatty acids can be delivered to a resting gut via intravenous infusion of a short-chain triglyceride.
Bleiberg
B
B
Endocrine Research Unit, Mayo Medical School, Rochester, MN.
Beers
T R
TR
Persson
M
M
Miles
J M
JM
D000085:Acetates / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D014018:Tissue Distribution; D014215:Triacetin / Q000737:chemistry*
D000085:Acetates; D014215:Triacetin