The control of apoptosis in mammalian cells.
This article summarizes what is now known, more than 100 years after this prescient observation, of the mechanisms by which death of mammalian cells is regulated. Particular attention is paid to the elimination of self-reactive thymocytes, the induction of cell death during cancer therapy and the mechanism(s) by which cells die following growth factor removal.
Collins
M K
MK
Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
Lopez Rivas
A
A
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D006801:Humans; D013601:T-Lymphocytes / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology*