title: Cytogenetic studies of primary cultures of esophageal squamous cell carcinoma.
abstract: Cytogenetic analysis was performed on primary cultures of 21 squamous cell carcinomas of the esophagus (SCCE). Seven cases exhibited mosaic clonal chromosome abnormalities distributed as follows: two contained tetraploid cell populations, one with t(3;7)(p21;q11); two showed loss of the Y chromosome, one with double minutes; single cases demonstrated der(11)t(4;11)(q?27;q23); add(1)(p35) and del(4)(p12); and del(7)(p13), del(7)(q22q34), and der(11)t(7;11)(p?15;p?13). The remaining 14 cases had apparently normal karyotypes, possibly derived from stromal elements. These results demonstrate numerical abnormalities and the multiple occurrence of rearrangements involving chromosomes 7 and 11 in SCCE.
authors.affiliation: Department of Obstetrics/Gynecology, University of Maryland School of Medicine, Baltimore 21201.
authors.forename: L S
authors.initials: LS
authors.lastname: Rosenblum-Vos
authors.forename: S J
authors.initials: SJ
authors.lastname: Meltzer
authors.forename: J
authors.initials: J
authors.lastname: Leana-Cox
authors.forename: S
authors.initials: S
authors.lastname: Schwartz
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D011123:Polyploidy; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured