Thrombosis induced by endothelin (ET-1) and carrageenin in rats treated with indomethacin and propionyl carnitine.
Propionyl carnitine can prevent endothelin and carrageenin-induced thrombosis in the rat's tail. This protective action of propionyl carnitine is probably related to its capacity to increase the synthesis of PGI2 prostaglandins and, subsequently, the amount of prostaglandins released by endothelin. Indomethacin, a well known prostanoid synthesis blocker, is unable to inhibit the protective activity of propionyl carnitine on endothelin-induced thrombosis after prolonged propionyl carnitine administration, but only a part of this protective activity after propionyl carnitine acute administration. Subsequently, other factors in addition to prostanoids seem to be involved in protective mechanisms of propionyl carnitine on endothelin-induced thrombosis.
Bertelli
A
A
Department of Medical Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Bertelli
A A
AA
Galmozzi
G
G
Giovannini
L
L
Mian
M
M
D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002331:Carnitine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002351:Carrageenan; D015777:Eicosanoids / Q000096:biosynthesis; D016232:Endothelins; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000139:chemically induced* / Q000517:prevention & control*
D002316:Cardiotonic Agents; D015777:Eicosanoids; D016232:Endothelins; C003223:propionylcarnitine; D002351:Carrageenan; D002331:Carnitine; D007213:Indomethacin