[Evaluation of humoral immune response in patients with asymptomatic and symptomatic HIV infection. Analysis of titers of anti-Hbs, antibodies against cytomegalovirus, herpes simplex virus type I, rubella virus and toxoplasma gondii].
40 asymptomatic HIV carriers and 45 AIDS patients were tested for anti-HBs (Hepatitis B Virus surface antigen), anti-RV (Rubella virus), anti-Toxo (Toxoplasma gondii), anti-CMV (Cytomegalovirus) and anti-HSV-1 (Herpes simplex virus type 1) antibody titers and compared with 83 persons characterized by risk behaviours but seronegative for HIV. The prevalence of these antibodies was very high and similar in all three groups studied, however, patients with AIDS had generally lower antibody titers when compared with asymptomatic carriers. The only exception being anti-HSV-1 which was present in high titre even in gravely ill patients. It seems that subjects with clinically overt HIV infection develop a serious disturbance in the humoral immune response with depressed specific antibody synthesis.
Radkowski
M
M
Zákład Immunopatologii, Instytut Chorób Zakaźnych i Pasozytniczych Akademii Medycznej, Warszawie.
Laskus
T
T
Kopicz-Kamińska
E W
EW
Mian
M
M
Szymańska
B
B
Babiuch
L
L
Slusarczyk
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D000914:Antibodies, Viral / Q000032:analysis*; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D018023:HIV Seronegativity / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D012412:Rubella virus / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D014122:Toxoplasma / Q000276:immunology
D000913:Antibodies, Protozoan; D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens
Ocena humoralnej odpowiedzi immunologicznej u pacjentów z bezobjawowym i objawowymi zakazeniem HIV. Analiza mian przeciwciał anty-HBs, przeciwko wirusowi cytomegalii, herpes simplex typ I, rózyczki oraz Toxoplasma gondii.