Respiratory depression following combination of epidural buprenorphine and intramuscular ketorolac.
A 48-year-old man who had undergone thoracotomy for carcinoma of the middle third of his oesophagus developed severe postoperative respiratory depression following intramuscular ketorolac 30 mg 2 h after 150 micrograms epidural buprenorphine. Summation of analgesia by drugs used in combination can have deleterious respiratory effects.
Jain
P N
PN
Department of Anaesthesia, Tata Memorial Hospital, Parel, Bombay, India.
Shah
S C
SC
D015360:Analgesia, Epidural / Q000009:adverse effects; D000700:Analgesics / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002047:Buprenorphine / Q000009:adverse effects*; D003864:Depression, Chemical; D004347:Drug Interactions; D004938:Esophageal Neoplasms / Q000601:surgery; D016629:Esophagectomy; D006801:Humans; D007273:Injections, Intramuscular; D020910:Ketorolac; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D014046:Tolmetin / Q000009:adverse effects / Q000031:analogs & derivatives*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002047:Buprenorphine; D014046:Tolmetin; D020910:Ketorolac