Gentamicin toxicosis in a North American cougar.
This report documents nephrotoxicosis in a North American cougar (Felis concolor) caused by gentamicin overdose and describes a method of calculating drug dosages by metabolic scaling for species in which pharmacokinetic studies have not been performed. Determining drug dosages by metabolic scaling can decrease the likelihood of administering inappropriate drug doses in exotic animals.
Johnson
J H
JH
Department of Large Animal Medicine and Surgery, Texas Veterinary Medical Center, College of Veterinary Medicine, Texas A&M University, College Station 77843-4475.
Wolf
A M
AM
Johnson
T L
TL
Jensen
J M
JM
D000505:Alopecia / Q000139:chemically induced / Q000662:veterinary; D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000662:veterinary; D001733:Bites and Stings / Q000188:drug therapy / Q000662:veterinary; D002335:Carnivora; D062787:Drug Overdose / Q000662:veterinary; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051437:Renal Insufficiency / Q000139:chemically induced / Q000662:veterinary; D014511:Uremia / Q000139:chemically induced / Q000662:veterinary
D005839:Gentamicins