Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus.
Long-term depression of synaptic transmission was induced following the prior induction of long-term potentiation in the CA1 region of rat hippocampal slices. We show that the induction of this form of synaptic depression can be prevented by (+)-alpha-methyl-4-carboxyphenylglycine, a selective antagonist of metabotropic glutamate receptors.
Bashir
Z I
ZI
Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK.
Jane
D E
DE
Sunter
D C
DC
Watkins
J C
JC
Collingridge
G L
GL
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D004558:Electric Stimulation; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D001565:Benzoates; D018094:Receptors, Metabotropic Glutamate; C079694:alpha-methyl-4-carboxyphenylglycine; D005998:Glycine