Activity of a nitrofurazone matrix urinary catheter against catheter-associated uropathogens.
Nitrofurazone-coated urinary catheter segments inhibited 51 (75%) of 70 urinary bacterial isolates from patients with indwelling catheters. Inhibition zones correlated significantly with the nitrofurazone MIC (r2 = 0.79, P = 0.0001). All strains except the Pseudomonas spp. were inhibited by < or = 64 micrograms of nitrofurazone per ml. MICs of nitrofurazone and nitrofurantoin correlated significantly (r2 = 0.93, P = 0.0001).
Johnson
J R
JR
Department of Medicine, University of Minnesota, Minneapolis 55455.
Berggren
T
T
Conway
A J
AJ
D001419:Bacteria / Q000187:drug effects*; D002408:Catheters, Indwelling / Q000009:adverse effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D009583:Nitrofurazone / Q000008:administration & dosage / Q000494:pharmacology*; D013242:Sterilization; D014546:Urinary Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D014552:Urinary Tract Infections / Q000382:microbiology*
D009582:Nitrofurantoin; D009583:Nitrofurazone