title: Bis-naphthalimides: a new class of antitumor agents.
abstract: A series of bis-intercalators bearing the 1,8-naphthalimide chromophore has been synthesized and in vitro activities determined. Most compounds have higher activities in HT-29 than the leader compounds Mitonafide and Amonafide. One of them (22) was selected for in vivo studies and presents an interesting activity in MX-1 and OVCAR models. (22) also acts as antitopoisomerase II.
authors.affiliation: Laboratorios Knoll S. A, Madrid, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Braña
authors.forename: J M
authors.initials: JM
authors.lastname: Castellano
authors.forename: M
authors.initials: M
authors.lastname: Morán
authors.forename: M J
authors.initials: MJ
authors.lastname: Pérez de Vega
authors.forename: C R
authors.initials: CR
authors.lastname: Romerdahl
authors.forename: X D
authors.initials: XD
authors.lastname: Qian
authors.forename: P
authors.initials: P
authors.lastname: Bousquet
authors.forename: F
authors.initials: F
authors.lastname: Emling
authors.forename: E
authors.initials: E
authors.lastname: Schlick
authors.forename: G
authors.initials: G
authors.lastname: Keilhauer
mesh_terms: D000225:Adenine; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053644:Naphthalimides; D009374:Neoplasms, Experimental / Q000188:drug therapy; D063065:Organophosphonates; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D007094:Imides; D007364:Intercalating Agents; D007546:Isoquinolines; D009281:Naphthalenes; D053644:Naphthalimides; D063065:Organophosphonates; C019215:mitonafide; C037020:amonafide; D000225:Adenine