Monitoring occupational exposure to carcinogens.
32P-Postlabelling has been used for biomonitoring occupational exposure to complex mixtures of polycyclic aromatic hydrocarbons in iron foundries, coke oven and aluminium plants and among roofers and surface-coating workers. Enhanced levels of aromatic DNA adducts have been detected in exposed populations in comparison to controls. Dose-related adduct formation has been found in iron foundry and coke-oven workers and roofers. The importance of longitudinal biomonitoring has been shown in two aluminium plants. Comparison between 32P-postlabelling and immunoassays revealed wide variations. DNA adduct levels obtained by the current methods should thus be regarded as relative values between individuals and control and exposure groups.
Schoket
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Department of Biochemistry, Johan Béla National Institute of Public Health, Budapest, Hungary.
D002273:Carcinogens / Q000008:administration & dosage* / Q000633:toxicity; D004247:DNA / Q000032:analysis; D004249:DNA Damage; D004784:Environmental Monitoring / Q000379:methods* / Q000706:statistics & numerical data; D005069:Evaluation Studies as Topic; D006801:Humans; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D009790:Occupations; D010761:Phosphorus Radioisotopes; D012680:Sensitivity and Specificity; D015719:Single-Strand Specific DNA and RNA Endonucleases
D002273:Carcinogens; D010761:Phosphorus Radioisotopes; D004247:DNA; D015719:Single-Strand Specific DNA and RNA Endonucleases