Chronobiology and chronotherapy of malaria: investigations with murine malaria models.
The schizogonic rhythm of rodent malarias in the blood of mice varies from one species or subspecies to the other. Synchronous strains enable a precise study of the sensitive stage of the parasite to antimalarial drugs. Asynchronous strains are less sensitive than synchronous strains because of the delayed penetration of merozoites into red blood cells.
Landau
I
I
Laboratoire de Biologie Parasitaire et Chimiothérapie associé au CNRS (URA 114), Muséum National d'Histoire Naturelle, Paris, France.
Caillard
V
V
Beaute-Lafitte
A
A
Chabaud
A
A
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000494:pharmacology; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D004351:Drug Resistance; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D051379:Mice / Q000469:parasitology*; D010961:Plasmodium / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D013045:Species Specificity
D000962:Antimalarials