[The effect of IL-2 on IL-2 production and on the IL-2R expression of spleen cell from mice infected with M. tuberculosis H37Rv].
36 mice infected with M. tuberculosis H37 Rv were divided into treated group and untreated group at random. 18 infected mice were in treated group with appropriate dose of human recombinant interleukin-2. Normal group consists of 10 normal mice. At 10, 20, 30 day after treatment, IL-2 production and IL-2R expression of mice spleen cells from all three groups were detected. The results showed that: 1) IL-2 and IL-2R level in untreated group was lower than that in treated group and in normal group; 2) In vivo administration of rIL-2 could enhance IL-2 production and IL-2R expression.
Shan
W S
WS
Department of Immunology, Hubei Medical College, Wuhan.
D000818:Animals; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000627:therapeutic use*; D051379:Mice; D009169:Mycobacterium tuberculosis; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013154:Spleen / Q000378:metabolism; D014376:Tuberculosis / Q000276:immunology / Q000628:therapy*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins