[The roles of monocytes and the interaction between monocyte and T cell in human immune suppression induced by trichosanthin].
This paper deals with the roles of monocytes and the interaction between T cell and monocyte in Trichosanthin-induced human immune suppression. The data strongly argue that (a) monocytes could mediate the immune suppression of Trichosanthin, but T cells alone could not; (b) T cells acquire the ability to mediate the suppression effect if they were pulsed with Trichosanthin together with monocytes; (c) Antipain, a blocking agent against antigen processing and presentation, could diminish the suppressive activity of the Trichosanthin-pulsed monocytes. The results suggested the dependence of Trichosanthin on monocyte in immune down-regulation. One of the mechanisms might be that Trichosanthin induces an inhibitory network through antigen processing and presentation by monocytes.
Tao
J X
JX
Shanghai Institute of Immunology, Shanghai Second Medical University.
Chou
K Y
KY
D000976:Antipain / Q000494:pharmacology; D002450:Cell Communication / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D007165:Immunosuppression Therapy; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D015978:Trichosanthin / Q000494:pharmacology*
D000976:Antipain; D015978:Trichosanthin