New sesquiterpene alpha-methylene lactones from the Egyptian plant Jasonia candicans.
Extracts of the plant Jasonia candicans possess antimicrobial activity. ET2O/MeOH extracts were subjected to liquid chromatography, and several sesquiterpenes were isolated and identified including the known compounds confertin [1], 4,11(13)-eudesmadien-12-oic acid [2], and 11-eudesmen-4-ol [3]. Two new diol alpha-methylene lactone antimicrobial agents were identified from nmr and mass spectral data and X-ray crystallography as (4 alpha, 5 alpha, 8 beta, 10 beta)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide [4] and (4 alpha, 5 alpha, 8 beta, 10 alpha)-4,10-dihydroxyl-1,11 (13)-guaidien-12,8-olide[5], which differ in stereochemistry at the C-10 tertiary alcohol center.
Ahmed
A A
AA
Department of Chemistry, Faculty of Science, El-Minia University, Egypt.
Mahmoud
A A
AA
Williams
H J
HJ
Scott
A I
AI
Reibenspies
J H
JH
Mabry
T J
TJ
D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes