title: Dynamic imaging with T2* contrast using U-FLARE.
abstract: Dynamic changes in T2* in the rat brain induced by the injection of Gd-DTPA are monitored using the U-FLARE sequence. Sensitivity to T2* is easily introduced into this sequence and may be freely varied. The images obtained display an adequate spatial resolution and contrast, for a temporal resolution of 1 s. Intensity-time curves and parametric images of regional cerebral blood flow (rCBV) are presented for three different blood pCO2 values. The results presented clearly demonstrate that U-FLARE is a viable method for dynamically measuring changes in T2*, and thus has application in imaging of both perfusion and functional activation.
authors.affiliation: Fachbereich Chemie, Universität Bremen, Germany.
authors.forename: D G
authors.initials: DG
authors.lastname: Norris
authors.forename: M
authors.initials: M
authors.lastname: Hoehn-Berlage
authors.forename: F
authors.initials: F
authors.lastname: Wittlich
authors.forename: T
authors.initials: T
authors.lastname: Back
authors.forename: D
authors.initials: D
authors.lastname: Leibfritz
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D019786:Gadolinium DTPA; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D051381:Rats
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA