Bacterial lysates and ribosomes as inducers of specific immune responses: a comparative study.
A bacterial lysate (OM-85 BV), a preparation of purified bacterial ribosomes (D53) and a placebo were tested for ability to induce the local appearance of specific antibody-containing cells. The three compounds were given orally to 90 children who required tonsillectomy. Surgery was carried out after 1 month of therapy. Frozen-cut sections of each tonsil were tested in indirect immunofluorescence. Cells containing antibodies directed to Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae or Klebsiella pneumoniae were enumerated. Lowest values were noted in the placebo group. Slightly higher numbers were observed after treatment with OM-85 BV, but significant increases were noted only for the elevated numbers of specific antibody-containing cells observed after D53 therapy. Bacterial ribosomal preparations thus contribute efficient induction of specific local immune responses in man.
Béné
M C
MC
Laboratoire d'Immunologie, Faculté de Médecine de Nancy, Vandoeuvre lès Nancy, France.
Kahl
L
L
Perruchet
A M
AM
Hermes
H
H
Mösges
M
M
Normier
G
G
Binz
H
H
Faure
G C
GC
D000276:Adjuvants, Immunologic; D000293:Adolescent; D000907:Antibodies, Bacterial / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology*; D001419:Bacteria; D001428:Bacterial Vaccines / Q000276:immunology*; D002457:Cell Extracts; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005455:Fluorescent Antibody Technique; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae / Q000276:immunology; D006801:Humans; D007109:Immunity; D007711:Klebsiella pneumoniae / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology; D022242:Pneumococcal Vaccines; D012270:Ribosomes / Q000276:immunology*; D022541:Streptococcal Vaccines; D013296:Streptococcus pneumoniae / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology; D014068:Tonsillectomy; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D002457:Cell Extracts; D018073:Haemophilus Vaccines; D022242:Pneumococcal Vaccines; D022541:Streptococcal Vaccines; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates; C024220:D 53