title: Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trichostrongylus colubriformis.
abstract: The kinetic disposition of [14C]-oxfendazole (OFZ) and its metabolites, fenbendazole (FBZ) and fenbendazole sulphone (FBZ.SO2), in plasma and abomasal fluid were determined in Merino sheep and Angora goats before and during infection with Trichostrongylus colubriformis and Haemonchus contortus. The systemic availability (area under the plasma curve, AUC) of OFZ was significantly lower in goats (13.5 micrograms.h/ml) than in sheep (22.2 micrograms.h/ml) and was reduced with infection in goats (5.6 micrograms.h/ml) and sheep (15.1 micrograms.h/ml). The elimination of plasma [14C] was faster in goats than in sheep. The responses observed for [14C] were a reflection of the behaviour of OFZ. The concentration of OFZ and metabolites in abomasal fluid were similar in both species in the absence or presence of infection. However, as the mean flow rate of abomasal fluid was slower in goats (240 ml/h) than in sheep (488 ml/h), only 7% of the dose passed the pylorus in abomasal fluid of goats compared with 14% in sheep. The presence of gastrointestinal nematodes generally increased abomasal fluid flow rate but neither species nor infection had any effect on the rate or extent of [14C] excretion in urine or faeces. It is suggested that goats possess a faster hepatic metabolism than sheep resulting in more rapid elimination of OFZ.
authors.affiliation: CSIRO Division of Animal Health, McMaster Laboratory, Glebe, NSW, Australia.
authors.forename: D R
authors.initials: DR
authors.lastname: Hennessy
authors.forename: N C
authors.initials: NC
authors.lastname: Sangster
authors.forename: J W
authors.initials: JW
authors.lastname: Steel
authors.forename: G H
authors.initials: GH
authors.lastname: Collins
mesh_terms: D000018:Abomasum / Q000378:metabolism; D000818:Animals; D000969:Antinematodal Agents / Q000493:pharmacokinetics*; D001562:Benzimidazoles / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D015511:Goat Diseases / Q000378:metabolism* / Q000469:parasitology; D006041:Goats; D006188:Haemonchiasis / Q000378:metabolism / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects / Q000254:growth & development; D008099:Liver / Q000378:metabolism; D012756:Sheep; D012757:Sheep Diseases / Q000378:metabolism* / Q000469:parasitology; D014253:Trichostrongylosis / Q000378:metabolism / Q000662:veterinary*; D014254:Trichostrongylus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000969:Antinematodal Agents; D001562:Benzimidazoles; C011030:oxfendazole