Chemical characteristics of complexes of O6,9-dimethylguanine with cis-platin and debenzylation rates of O6-benzylguanines.
Complexes of O6,9-dimethylguanine with cisplatin were synthesized and their chemical characteristics were studied in relation to the function of the repair enzyme, O6-alkylguanine-DNA alkyltransferase (AGAT). In addition, dealkylation rates of O6-benzylguanine derivatives, that are though to be better substrates for AGAT, were determined by the thiophenol-Et3N system.
Terashima
I
I
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Koyama
K
K
Kohda
K
K
D000478:Alkylation; D002851:Chromatography, High Pressure Liquid; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D008780:Methyltransferases / Q000378:metabolism; D019853:O(6)-Methylguanine-DNA Methyltransferase; D009944:Organoplatinum Compounds / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013379:Substrate Specificity
D009944:Organoplatinum Compounds; C064976:O(6)-benzylguanine; C074484:cis-diamminebis(O(6),9-dimethylguanine-7)platinum(II); D006147:Guanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase