title: [Effect of postoperative chemotherapy on the reproductive function and offspring health in patients with ovarian neoplasms].
abstract: The reproductive function and their offspring health in 30 patients with ovarian neoplasms following preservation of tubo-ovarian and uterine functions operation, and adjuvant or preventive chemotherapy were studied. All the patients were followed up for 2-18.5 years, 65.5% of the patients showed normal cycle of menstruation. The patients under 25 years old, they were demonstrated a significant higher frequency of abnormal menstruation than that over 25. In this series 15 patients wish to have child, 12 of them were pregnant (a gestational rate of 80%), totally there are 20 gestations, including 13 fullterm deliveries, 1 premature delivery, and 7 artificial abortions, however, no spontaneous abortion occurred. Fourteen healthy offsprings were followed up to date, 11 of them are normal in health, the Gesell tests of intelligence were also normal, as well as the G-band karyotype analysis. Only the SCE frequencies of 3 objects in one family comprised the mother and her two daughters were significant higher than that of the control. We recommend that women who preserving reproductive function desired to be pregnant at least 2 years later following chemotherapy, SCE determination must be studied before any attempt to become pregnancy.
authors.affiliation: Tongji Medical University, Wuhan.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gu
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004407:Dysgerminoma / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D011247:Pregnancy; D011256:Pregnancy Outcome; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013724:Teratoma / Q000188:drug therapy / Q000601:surgery