Activity of meropenem and other antimicrobial agents against uncommon gram-negative organisms.
The in-vitro activity of meropenem and other antimicrobial agents was tested by agar dilution against 113 uncommon Gram-negative pathogens. Both meropenem and ceftriaxone showed the most activity against the test isolates. The potency of meropenem was greater than imipenem against Pasteurella multocida, Eikenella corrodens, Haemophilus parainfluenzae, Moraxella spp., Kingella spp., and Actinobacillus actinomycetemcomitans. Further work is necessary to assess the in-vivo activity of meropenem against these Gram-negative isolates.
Clark
R B
RB
Department of Pathology, Crozer-Chester Medical Center, Upland, PA 19013.
Joyce
S E
SE
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D013845:Thienamycins; D015378:Imipenem; D002443:Ceftriaxone; D000077731:Meropenem