Syrinx extending from conus medullaris to basal ganglia: a clinical, radiological, and pathological correlation.
A 41-year-old woman with a history of birth injury to the brachial plexus suffered several delayed episodes of neurological deterioration. Magnetic resonance imaging studies revealed a syrinx extending from the conus medullaris into the brainstem and rostrally into both internal capsules. She died of an acute exacerbation of chronic respiratory failure. Autopsy demonstrated syringomyelia and syringobulbia with cavity extension bilaterally along the corticospinal tracts into the internal capsules. Islands of glial tissue in the subarachnoid space around the medulla caused obstruction of the subarachnoid space at the foramen magnum. These were probably the result of birth injury to the cerebellum. A detailed clinico-pathological correlation is provided to explain her neurological deficits. The pathogenesis of syrinx formation is discussed in terms of a late manifestation of birth trauma.
Del Bigio
M R
MR
Department of Pathology, University of Toronto, Ontario, Canada.
Deck
J H
JH
MacDonald
J K
JK
D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D001720:Birth Injuries / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005402:Fistula / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008526:Medulla Oblongata / Q000000981:diagnostic imaging / Q000473:pathology*; D009483:Neuropsychological Tests; D011859:Radiography; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000473:pathology; D013595:Syringomyelia / Q000000981:diagnostic imaging / Q000473:pathology