[Characterization of two antigens OC41 D and OC41 E associated with ovarian carcinoma].
Two antigens, OC41D and OC41E, were characterized by two monoclonal antibodies (COC41D and COC41E) generated with the antigens (OC41) as immunogen, which were dissociated from immune complex in a patient with ovarian carcinoma. The expressing rates of the antigen OC41D and OC41E were 70.2% and 52.5% in epithelial ovarian cancer. They were mainly detected on the membrane of the cancer cells, also a little in the plasma. Two antigens were found no cross reactivities with HIA, CEA, alpha-FP, and beta-MG. Their express were not related to cell circle. Antigen OC41D might be a protein with molecular weight of 62,000 and could not be denatured by heating. Antigen OC41E might be a glycoprotein with molecular weight of 15,000. These two antigens may be new antigens highly associated with ovarian carcinoma.
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People's Hospital, Beijing Medical University.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000276:immunology*; D002277:Carcinoma / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D010051:Ovarian Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006023:Glycoproteins; C017589:ovarian tumor associated antigen