Preliminary study on the anti-radiation effect of jen-sheng-yang-yung-tang.
Six to seven week old male mice of ICR strain were exposed to different doses of x-rays to determine if jen-sheng-yang-yung-tang could be a modifier in the elimination of radiation damage. Colony forming units of bone marrow cells in the spleen (CFUs) were measured before and after x-ray irradiation with intraperitoneal injection of 10 mg/20 g or 20 mg/20 g body weight of jen-sheng-yang-yung-tang, once a day for seven consecutive days. The recovery of CFUs and hemocytes counts by 4 Gy irradiation with jen-sheng-yang-yung-tang administration was faster for a concentration of 20 mg/20 g than 10 mg/20 g. The measurement of 10-day CFUs showed an increase of radiotolerance in the treatment of 20 mg/20 g administration before x-ray irradiation. The injection of jen-sheng-yang-yung-tang accelerated the recovery of hemocyte counts in mice irradiated with 4 Gy x-ray; the effect was especially profound for leukocytes with 20 mg/20 g jen-sheng-yang-yung-tang administration after irradiation.
Hsu
H Y
HY
School of Technology for Medical Science, Department of Radiotherapy, Kaohsiung Medical College, Taiwan.
Ho
Y H
YH
Lian
S L
SL
Lin
C C
CC
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004906:Erythrocyte Count / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D013234:Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D014916:Whole-Body Irradiation; D014965:X-Rays
D004365:Drugs, Chinese Herbal; D011837:Radiation-Protective Agents