title: Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures is related to cortical oxygenation.
abstract: Cerebral blood flow and oxygenation increase during the early seizures of a series, but the increase in cerebral blood flow attenuates during late seizures, sometimes resulting in decreased cortical oxygenation. Cortical free fatty acids (FFA) and diacylglycerols also increase during early seizures and the increase attenuates during late seizures. We analyzed the correlation between lipid accumulation and cortical O2 during periodic pentylenetetrazol-induced seizures. During early seizures, both FFA and diacylglycerols increased in the cerebral cortex, particularly arachidonate (20:4) and stearate (18:0). Changes in lipids were different during late seizures, depending on cortical O2 levels. An increase in cortical O2 during late seizures was associated with lower FFA levels compared with early seizures, and FFA levels recovered to basal levels during interictal periods. A decline in cortical O2 was associated with a further increase in FFA, which remained elevated during interictal periods. Our results indicate that periseizure lipid accumulation is related to cortical oxygenation.
authors.affiliation: LSU Eye Center and Neuroscience Center, New Orleans 70112.
authors.forename: F
authors.initials: F
authors.lastname: Visioli
authors.forename: L L
authors.initials: LL
authors.lastname: Rihn
authors.forename: E B
authors.initials: EB
authors.lastname: Rodriguez de Turco
authors.forename: N R
authors.initials: NR
authors.lastname: Kreisman
authors.forename: N G
authors.initials: NG
authors.lastname: Bazan
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D002540:Cerebral Cortex / Q000378:metabolism* / Q000503:physiopathology; D004075:Diglycerides / Q000378:metabolism*; D004569:Electroencephalography; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D010313:Partial Pressure; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D013229:Stearic Acids / Q000378:metabolism; D013997:Time Factors
chemical_list: D004075:Diglycerides; D005230:Fatty Acids, Nonesterified; D010169:Palmitic Acids; D013229:Stearic Acids; D002245:Carbon Dioxide; D016718:Arachidonic Acid; D019308:Palmitic Acid; C031183:stearic acid; D003576:Electron Transport Complex IV; D010100:Oxygen; D010433:Pentylenetetrazole