Androgenic granulosa cell tumor of the ovary: in vivo hormonal studies.
Androgenic granulosa cell tumors of the ovary are rare and have not been well studied hormonally. A 20-year-old woman complaining of secondary amenorrhea with high plasma testosterone (295 ng/dl) and a right ovarian tumor was studied. Plasma testosterone levels decreased after two days of dexamethasone (36 ng/dl), increased after hCG administration (538 ng/dl) and a unilateral right ovarian gradient of testosterone was noted at the selective catheterization of ovarian veins. After removal of the granulosa cell tumor, testosterone concentration returned to normal (68 ng/dl) and the patient had resumption of normal menses.
Caron
P
P
Service d'Endocrinologie, CHU Rangueil, Toulouse, France.
Cogne
M
M
Rumeau
J L
JL
Hoff
J
J
D000328:Adult; D000568:Amenorrhea / Q000097:blood* / Q000209:etiology; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood* / Q000150:complications; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood* / Q000150:complications; D013739:Testosterone / Q000097:blood*
D013739:Testosterone