title: [Fatal fulminant hepatitis induced by nilutamide (Anandron)].
abstract: The first case of fatal fulminant hepatitis probably caused by nilutamide, a non steroidal antiandrogen derivative, is reported. Nilutamide administration had been continued for 6 days after the occurrence of jaundice, 52 days after beginning of treatment. The rapidly fatal outcome might have been promoted by coadministration of phenobarbital.
authors.affiliation: Service d'Hépatologie, Hôpital Beaujon, Clichy.
authors.forename: P
authors.initials: P
authors.lastname: Pescatore
authors.forename: P
authors.initials: P
authors.lastname: Hammel
authors.forename: F
authors.initials: F
authors.lastname: Durand
authors.forename: P
authors.initials: P
authors.lastname: Bertheau
authors.forename: J
authors.initials: J
authors.lastname: Bernuau
authors.forename: D
authors.initials: D
authors.lastname: Huc
authors.forename: J L
authors.initials: JL
authors.lastname: Gerbal
authors.forename: C
authors.initials: C
authors.lastname: Degott
authors.forename: J P
authors.initials: JP
authors.lastname: Benhamou
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D004347:Drug Interactions; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D048289:Imidazolidines; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000188:drug therapy
chemical_list: D000726:Androgen Antagonists; D007093:Imidazoles; D048289:Imidazolidines; C021277:nilutamide; D010634:Phenobarbital
vernacular_title: Hépatite fulminante mortelle imputable au nilutamide (Anandron).