[Formulation of diazepam suppositories, results of rheological and biopharmaceutical studies. 2. In vitro membrane diffusion and in vivo absorption results].
In the first part of the publication the rheological properties of the vehicles used for the production of suppositories were studied in order to determine the ideal parameters for formulation. In this part a detailed methodology and the results of the in vitro membrane diffusion and in vivo bioavailability studies, are presented. The results confirm a general correlation between the in vitro and the in vivo findings. It seems that hydrophilic macrogol-mixture with great molecular mass can be recommended as the optimal vehicle for formulation of diazepam suppositories.
Bácskay
I
I
SZOTE Gyógyszertechnológiai Intézet, Szeged.
Regdon
G
G
Kata
M
M
Selmeczi
B
B
Szikszay
M
M
Sánta
A
A
Bálint
G S
GS
D000818:Animals; D001682:Biological Availability; D003975:Diazepam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004058:Diffusion; D007408:Intestinal Absorption; D008567:Membranes, Artificial; D051381:Rats; D017208:Rats, Wistar; D013488:Suppositories
D008567:Membranes, Artificial; D013488:Suppositories; D003975:Diazepam
Diazepám-tartalmú végbélkúpok formulálása, reológiai és biofarmáciai vizsgálatának tapasztalatai. 2. In vitro membrándiffúziós és in vivo felszívódási eredmények.