title: Are pill counts valid measures of compliance in clinical obstetric trials?
abstract: We compared pill counts with a biochemical measure of compliance in 283 women who participated in a randomized double-blind trial that evaluated the efficacy of low-dose aspirin in the prevention of preeclampsia. Subjects whose pill counts indicated a usage > 100% were less compliant than women with lower pill counts.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333.
authors.forename: M B
authors.initials: MB
authors.lastname: DuBard
authors.forename: R L
authors.initials: RL
authors.lastname: Goldenberg
authors.forename: R L
authors.initials: RL
authors.lastname: Copper
authors.forename: J C
authors.initials: JC
authors.lastname: Hauth
mesh_terms: D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010349:Patient Compliance; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D013929:Thromboxane B2; D001241:Aspirin