title: [Giant cell arteritis, synonym of Horton disease?].
abstract: Giant cell arteritis: a synonym of Horton's disease? Biopsies from the temporal artery of 50 patients with Horton disease were evaluated retrospectively by light microscopy and immunohistochemical methods. All patients were adults over 60 years: 28 female, 22 male. Histopathologic study of the biopsies disclosed four main variants most likely related to different stages of temporal arteritis. Only in 22 cases the typical granulomatous giant-cell pattern was observed. However similar pathologic findings occur in several other chronic vasculitis, granulomatous giant cell inflammation being a mark of an advanced stage of the disease rather than a mark of a specific type of arteritis. Therefore <<Horton disease>> and <<giant-cell arteritis>> cannot be considered synonymous, contrary to what usually happens in clinical practice.
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze.
authors.forename: F
authors.initials: F
authors.lastname: Gori
authors.forename: A
authors.initials: A
authors.lastname: Caldarella
authors.forename: M
authors.initials: M
authors.lastname: Dini
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D013700:Giant Cell Arteritis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013699:Temporal Arteries / Q000473:pathology*
vernacular_title: Arterite gigantocellulare, sinonimo di malattia di horton?