A second glucagon in the pancreatic islets of the daddy sculpin Cottus scorpius.
The peptide hormone glucagon has been isolated from the islet tissue (Brockmann bodies) of the teleost Cottus scorpius (daddy sculpin) and sequenced. The sequence is HSEGTSNDYSKYLEDRKAQDFVQWLMNN differing at four positions from the glucagon found earlier in the same species by Conlon and coworkers (1987b, Eur. J. Biochem, 164, 117-122). Thus sculpin, in common with anglerfish, possesses two distinct glucagons. Comparative sequence data are presented as a phylogenetic tree.
Cutfield
S M
SM
Biochemistry Department, University of Otago, Dunedin, New Zealand.
Cutfield
J F
JF
D000595:Amino Acid Sequence; D000818:Animals; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005399:Fishes / Q000502:physiology*; D005934:Glucagon / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism*; D008969:Molecular Sequence Data; D010802:Phylogeny; D013045:Species Specificity
D005934:Glucagon