Flumazenil prevents the anxiolytic effects of diazepam, alprazolam and adinazolam on the early acquisition of two-way active avoidance.
The effects of diazepam (DZ, 4 mg/kg), alprazolam (ALP, 1.25 mg/kg) and adinazolam (ADIN, 6 mg/kg), as well as their interaction with the benzodiazepine receptor antagonist flumazenil (Ro15-1788), were studied on the early acquisition of two-way active (shuttlebox) avoidance in male Sprague-Dawley rats. The three benzodiazepines increased shuttlebox avoidance acquisition, and their effects were prevented (antagonized) by flumazenil (10 mg/kg). The present results indicate that central benzodiazepine (BZ) receptors are involved in the anxiolytic effects of diazepam and triazolobenzodiazepines on the early acquisition of two-way active avoidance.
Escorihuela
R M
RM
Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, Spain.
Fernández-Teruel
A
A
Zapata
A
A
Núñez
J F
JF
Tobeña
A
A
D000525:Alprazolam / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology; D001921:Brain / Q000187:drug effects; D003975:Diazepam / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005442:Flumazenil / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005442:Flumazenil; C039668:adinazolam; D003975:Diazepam; D000525:Alprazolam