Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP).
The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.
Miller
K E
KE
Department of Anatomical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Douglas
V D
VD
Kaneko
T
T
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000166:cytology* / Q000201:enzymology / Q000378:metabolism*; D005972:Glutaminase / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000201:enzymology / Q000378:metabolism*; D009475:Neurons, Afferent / Q000201:enzymology / Q000378:metabolism; D017729:Presynaptic Terminals / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D005972:Glutaminase; D015740:Calcitonin Gene-Related Peptide