title: Salivary fluoride clearance after a single intake of fluoride tablets and chewing gums in children, adults, and dry mouth patients.
abstract: The aim of the present investigation was to compare the clearance pattern in saliva and the salivary stimulating effect of a new fluoride (F) chewing gum (Fluorette) with three other F products used in Scandinavia for many years for caries prevention. Concentration of F was determined in whole saliva in three groups of subjects: 1) children, 10-12 yr of age (n = 20), 2) adults (n = 20), and 3) dry mouth patients (n = 15), after a single intake of the two tablets, Dentan and Fludent, and the two chewing gums, Fluomin and Fluorette, all containing 0.25 mg F as NaF. Sucking was allowed until the tablets had been completely dissolved in the mouth. The chewing gums were used for 15 min. Saliva samples were collected from subjects expectorating 0.3-0.5 ml at nine different time intervals up to 45 min after the intake. There were some significant differences in the maximum F concentration, the area under the salivary fluoride concentration curve (AUC) when plotted against time, and the salivary stimulating effect among the four products, but as a whole they were small and probably of minor clinical importance. Among the various groups, the dry mouth patients showed the highest salivary F concentration. Thus, the main conclusion from this study is that the F tablets and chewing gums studied, including the new product Fluorette, had approximately the same clearance pattern in saliva and the same salivary stimulating effect. However, there were great variations among the different subjects.
authors.affiliation: Department of Cariology and Department of Pedodontics, Faculty of Odontology, University of Göteborg, Gothenburg, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Sjögren
authors.forename: D
authors.initials: D
authors.lastname: Birkhed
authors.forename: L G
authors.initials: LG
authors.lastname: Persson
authors.forename: J G
authors.initials: JG
authors.lastname: Norén
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002638:Chewing Gum; D002648:Child; D005459:Fluorides / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012636:Secretory Rate; D012969:Sodium Fluoride / Q000008:administration & dosage; D013607:Tablets; D013997:Time Factors; D014987:Xerostomia / Q000378:metabolism*
chemical_list: D002638:Chewing Gum; D013607:Tablets; D012969:Sodium Fluoride; D005459:Fluorides