title: First-phase insulin release in normal children.
abstract: Normal values for the first-phase insulin release during an intravenous glucose tolerance test are not yet well defined for children and adolescents. In this study, 69 normal subjects (aged 7 to 22 years) who had no family history of type I diabetes, a normal glycohemoglobin value, and a negative islet cell antibody test result underwent a standard intravenous glucose tolerance test. The mean (+/- SEM) first-phase insulin release increased with age and pubertal status: 7 to 10 years, 93 +/- 10.1 mIU/L; 11 to 15 years, 172.7 +/- 22.3 mIU/L; and 16 to 22 years, 163 +/- 28.5 mIU/L. The mean intraindividual variability in 11 subjects who underwent a second test was 23.6%. Acute stress, as estimated by observer assessment or by blood catecholamine levels, did not significantly correlate with first-phase insulin release. We conclude that first-phase insulin release is markedly lower in prepubertal children than in adolescents and young adults.
authors.affiliation: Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262.
authors.forename: H F
authors.initials: HF
authors.lastname: Allen
authors.forename: B W
authors.initials: BW
authors.lastname: Jeffers
authors.forename: G J
authors.initials: GJ
authors.lastname: Klingensmith
authors.forename: H P
authors.initials: HP
authors.lastname: Chase
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D007328:Insulin