title: Validation of a metabolic prototype to assist in the treatment of insulin-dependent diabetes mellitus.
abstract: This paper describes the principles and prototyping of a computer system to assist in the treatment of patients with insulin-dependent (type 1) diabetes mellitus. The system adopts a mixed approach involving rule-based qualitative algebra and a dynamic mathematical model to define the relationships between insulin dosage, diet and glycaemic response. The rule-based system (KBS), implemented in PROLOG, can be used to generate qualitative therapeutic advice. These suggestions are quantified and rank-ordered by the use of a mathematical model of glucose-insulin interaction in type 1 diabetes mellitus, with parameters adjusted for individual patients. In this paper an overview of the integrated prototype, linking the KBS and model, is provided and a case study used to demonstrate the principles of the system in operation. The results of verification and validation work performed on the KBS are described.
authors.affiliation: Department of Endocrinology and Chemical Pathology, United Medical School of Guy's Hospital, University of London, UK.
authors.forename: E D
authors.initials: ED
authors.lastname: Lehmann
authors.forename: T
authors.initials: T
authors.lastname: Deutsch
authors.forename: A V
authors.initials: AV
authors.lastname: Roudsari
authors.forename: E R
authors.initials: ER
authors.lastname: Carson
authors.forename: P H
authors.initials: PH
authors.lastname: Sonksen
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D005069:Evaluation Studies as Topic; D005103:Expert Systems; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008838:Microcomputers; D008962:Models, Theoretical; D012680:Sensitivity and Specificity; D012984:Software; D012986:Software Validation; D013813:Therapy, Computer-Assisted
chemical_list: D001786:Blood Glucose; D007328:Insulin