title: Bacterial NADH-quinone oxidoreductases: iron-sulfur clusters and related problems.
abstract: Many bacteria contain proton-translocating membrane-bound NADH-quinone oxidoreductases (NDH-1), which demonstrate significant genetic, spectral, and kinetic similarity with their mitochondrial counterparts. This review is devoted to the comparative aspects of the iron-sulfur cluster composition of NDH-1 from the most well-studied bacterial systems to date.: Paracoccus denitrificans, Rhodobacter sphaeroides, Escherichia coli, and Thermus thermophilus. These bacterial systems provide useful models for the study of coupling Site I and contain all the essential parts of the electron-transfer and proton-translocating machinery of their eukaryotic counterparts.
authors.affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104.
authors.forename: V D
authors.initials: VD
authors.lastname: Sled
authors.forename: T
authors.initials: T
authors.lastname: Friedrich
authors.forename: H
authors.initials: H
authors.lastname: Leif
authors.forename: H
authors.initials: H
authors.lastname: Weiss
authors.forename: S W
authors.initials: SW
authors.lastname: Meinhardt
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumori
authors.forename: M W
authors.initials: MW
authors.lastname: Calhoun
authors.forename: R B
authors.initials: RB
authors.lastname: Gennis
authors.forename: T
authors.initials: T
authors.lastname: Ohnishi
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D004579:Electron Transport; D004926:Escherichia coli / Q000201:enzymology; D007506:Iron-Sulfur Proteins / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000037:antagonists & inhibitors / Q000737:chemistry*; D010231:Paracoccus denitrificans / Q000201:enzymology; D011522:Protons; D012242:Rhodobacter sphaeroides / Q000201:enzymology; D013045:Species Specificity; D016963:Thermus thermophilus / Q000201:enzymology
chemical_list: D001426:Bacterial Proteins; D007506:Iron-Sulfur Proteins; D008565:Membrane Proteins; D011522:Protons; D016660:NAD(P)H Dehydrogenase (Quinone)