title: Loco-regional management of early cancer of the breast.
abstract: Early detection of breast cancer and its treatment with breast conservation therapy (BCT) are major components of a strategy aimed at improving therapeutic outcome by treating disease earlier in its course. In this paper, we review the indications and contraindications for BCT, discuss principles of integrating the required diagnostic and therapeutic modalities, and present several areas of current controversy that pose the opportunity for appropriate clinical trials.
authors.affiliation: H. Lee Moffitt Cancer Center, University of South Florida, Tampa 33682-1079.
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: T
authors.initials: T
authors.lastname: Smith
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery*; D016896:Treatment Outcome