title: Multiple hamartoma syndrome with osteosarcoma.
abstract: Multiple hamartoma syndrome, also known as Cowden's disease, is a rare genodermatosis with characteristic mucocutaneous lesions associated with multiple internal abnormalities. We describe a patient having classic dermatologic manifestations of Cowden's disease and multiple neoplasia including follicular adenocarcinoma of the thyroid gland with lung metastasis, intraductal breast carcinoma within a fibroadenoma, and an osteosarcoma. To our knowledge, this is the first reported case of an osteosarcoma in Cowden's disease.
authors.affiliation: Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029-6574.
authors.forename: B C
authors.initials: BC
authors.lastname: Yen
authors.forename: H
authors.initials: H
authors.lastname: Kahn
authors.forename: A L
authors.initials: AL
authors.lastname: Schiller
authors.forename: M J
authors.initials: MJ
authors.lastname: Klein
authors.forename: R G
authors.initials: RG
authors.lastname: Phelps
authors.forename: M G
authors.initials: MG
authors.lastname: Lebwohl
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology*; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000473:pathology*; D006801:Humans; D012516:Osteosarcoma / Q000209:etiology / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000209:etiology / Q000473:pathology*