title: Evaluation of hemostatic function following Norplant-2 rods removal.
abstract: Women using the Norplant-2 rod system in Singapore have been shown to have a change in their hemostatic function. There is a decrease in vitamin K dependent factors II, VII and a tendency toward lowered fibrinolytic activity after use of Norplant-2 rods. There was also an increase in platelet number and accelerated-platelet aggregation. These changes are similar to those seen with the Norplant six-capsule system and it would appear that both systems do not activate the coagulation system or enhance a state of hypercoagulation. On removal of the Norplant-2 rods at the end of 5 years, the significant changes seen in hemoglobin function observed with Norplant-2 rod use remained.
authors.affiliation: Department of Obstetrics and Gynecology, National University Hospital, Singapore.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D004343:Drug Implants; D005167:Factor VII / Q000378:metabolism; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D011516:Prothrombin / Q000378:metabolism; D011517:Prothrombin Time; D012846:Singapore
chemical_list: D004343:Drug Implants; D016912:Levonorgestrel; D000244:Adenosine Diphosphate; D005167:Factor VII; D011516:Prothrombin; D003094:Collagen