title: The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis.
abstract: Feeding of fluorinated benzoic acids to fermentations of a Phoma sp. resulted in the biosynthesis of a series of novel fluorinated squalestatins. The feeding studies, isolation, structural elucidation and biological activities of these compounds are reported.
authors.affiliation: Department of Natural Products Discovery, Research Limited, Middlesex, U.K.
authors.forename: R J
authors.initials: RJ
authors.lastname: Cannell
authors.forename: M J
authors.initials: MJ
authors.lastname: Dawson
authors.forename: R S
authors.initials: RS
authors.lastname: Hale
authors.forename: R M
authors.initials: RM
authors.lastname: Hall
authors.forename: D
authors.initials: D
authors.lastname: Noble
authors.forename: S
authors.initials: S
authors.lastname: Lynn
authors.forename: N L
authors.initials: NL
authors.lastname: Taylor
mesh_terms: D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D002176:Candida albicans / Q000201:enzymology; D002851:Chromatography, High Pressure Liquid; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D005285:Fermentation; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism*; D015394:Molecular Structure; D051381:Rats; D014233:Tricarboxylic Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D001643:Bridged Bicyclo Compounds; D014233:Tricarboxylic Acids; D013186:Farnesyl-Diphosphate Farnesyltransferase