title: Cerebrospinal fluid ferritin in patients with meningitis and cerebral infarction or bleeding.
abstract: The diagnostic value of cerebrospinal fluid (CSF) ferritin was assessed in 30 patients with meningeal reaction (viral meningitis 10; bacterial meningitis 6; meningism 14) and in 37 patients with cerebrovascular disease (cerebral infarction 29; transient ischaemic attacks 4; cerebral haemorrhage 4). The control group comprised 13 subjects with minor neurological disorders. CSF-ferritin levels were not significantly different in the various subgroups, most patients having values within the normal reference interval (2-7 micrograms/l). A clearly elevated CSF-ferritin was seen in one patient with bacterial meningitis and in one patient with intraventricular bleeding. In patients with meningeal reaction, CSF-ferritin was significantly correlated to CSF-protein. Patients with cerebrovascular disease displayed significant correlations between CSF-albumin and CSF-IgG and between CSF-ferritin, CSF-albumin and CSF-IgG. The present study indicates that measurement of CSF-ferritin is of no practical clinical relevance in the evaluation of patients with meningeal reaction and cerebrovascular disease.
authors.affiliation: Department of Medicine Y, Gentofte Hospital, Copenhagen.
authors.forename: N
authors.initials: N
authors.lastname: Milman
authors.forename: N A
authors.initials: NA
authors.lastname: Graudal
authors.forename: T S
authors.initials: TS
authors.lastname: Olsen
authors.forename: J H
authors.initials: JH
authors.lastname: Wandall
authors.forename: N S
authors.initials: NS
authors.lastname: Pedersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D002544:Cerebral Infarction / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005293:Ferritins / Q000134:cerebrospinal fluid*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007223:Infant; D007231:Infant, Newborn; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid / Q000175:diagnosis; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D008875:Middle Aged
chemical_list: D000418:Albumins; D007074:Immunoglobulin G; D005293:Ferritins