title: Valve area and cardiac output in aortic stenosis: quantification by magnetic resonance velocity mapping.
abstract: Valve area and cardiac output were determined with magnetic resonance (MR) velocity mapping in 12 patients with aortic stenosis. Heart catheterization, Doppler echocardiography, and indicator dilution were performed for comparison. Left ventricle could be catheterized in only nine patients; in these cases, MR measured a mean valve area of 1.2 cm2 compared with 0.9 cm2 derived from catheterization data, with a mean difference of 0.2 cm2 between the 2 methods. The limits of agreement were [0.0, +0.5] cm2, less in patients with an important degree of concomitant regurgitation. In the whole material, MR measured a mean area of 1.1 cm2 compared with 1.2 cm2 derived from Doppler echocardiography data, with a mean difference of 0.1 cm2 and [-0.5, +0.6] cm2 as limits of agreement. In 11 patients the cardiac output was quantified by MR to a mean of 4.9 L/min and by indicator dilution to 5.0 L/min, with a mean difference of 0.2 L/min, and [-0.6, +0.8] L/min as limits of agreement. In addition, MR offers the major advance of simultaneous quantification of regurgitant volume in cases of concomitant regurgitation. In conclusion, because the two important prognostic determinants in aortic stenosis--the valvular area and the cardiac output--may be quantified, MR has potential to become a clinical tool in assessment of severity in aortic stenosis.
authors.affiliation: Danish Research Centre of Magnetic Resonance, Hvidovre Hospital, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Søndergaard
authors.forename: P
authors.initials: P
authors.lastname: Hildebrandt
authors.forename: K
authors.initials: K
authors.lastname: Lindvig
authors.forename: C
authors.initials: C
authors.lastname: Thomsen
authors.forename: F
authors.initials: F
authors.lastname: Ståhlberg
authors.forename: E
authors.initials: E
authors.lastname: Kassis
authors.forename: O
authors.initials: O
authors.lastname: Henriksen
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007201:Indicator Dilution Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged