Protective action of L-carnitine and coenzyme Q10 against hepatic triglyceride infiltration induced by hyperbaric oxygen and ethanol.
This investigation was conducted to ascertain whether administration of L-carnitine and coenzyme Q10 could protect from the experimentally-induced hepatic lipid infiltration and glutathione content decrease in rats exposed to hyperbaric oxygen and prolonged alcohol administration. The results indicate that administration of L-carnitine and coenzyme Q10 in association reduces damage induced by chronic alcohol poisoning and hyperbaric oxygen. This protective action is more marked when L-carnitine and coenzyme Q10 are administered together. The combined complementary biochemical activity of these two compounds is discussed.
Bertelli
A
A
Department of Medical Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Cerrati
A
A
Giovannini
L
L
Mian
M
M
Spaggiari
P
P
Bertelli
A A
AA
D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism*; D014451:Ubiquinone / Q000494:pharmacology*
D008054:Lipid Peroxides; D014280:Triglycerides; D014451:Ubiquinone; D000431:Ethanol; D005978:Glutathione; C025204:Ubiquinone Q2; D002331:Carnitine