[Serum soluble CD23 and soluble CD25 in bronchial asthmatic patients].
Serum sCD23 and sCD25 levels in asthmatic patients and healthy subjects were assayed. Serum sCD23 levels in asthmatic patients were significantly higher than those in healthy subjects (p < 0.05). Serum sCD25 levels in asthmatic patients were also significantly higher than those in healthy subjects (p < 0.02). There was a significant correlation between serum sCD23 and sCD25 levels in asthmatic patients (r = 0.52, p < 0.001). It is well known that sCD23 and sCD25 levels are regulated by different cytokines, and this study suggests that T cells play important roles in the pathogenesis of asthma.
Shiota
Y
Y
Department of Clinical Research, Kure Kyousai Hospital, Japan.
Sato
T
T
Ono
T
T
Kaji
M
M
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000032:analysis*; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012995:Solubility
D017455:Receptors, IgE; D015375:Receptors, Interleukin-2