Antitussive effect of captopril, an angiotensin converting enzyme inhibitor, in the rat.
The effects of acute treatment with captopril, an angiotensin converting enzyme inhibitor, on the capsaicin-induced cough reflex were examined in rats. Intraperitoneal injection of captopril in doses of 3 and 10 mg/kg decreased the number of coughs dose-dependently. Although the peak effect was similar to that of morphine (0.5 mg/kg), the duration of captopril's effect (10 mg/kg) was longer than that of morphine. Furthermore, while pretreatment with naloxone significantly decreased the duration of the antitussive effect of captopril, it had no significant effect on the early-phase (within 60 min) effect of captopril. These results suggest that the mechanism which underlies the antitussive effect of captopril involves mediation by both nonopioid and opioid systems.
Kamei
J
J
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Igarashi
H
H
Iwamoto
Y
Y
Tanihara
H
H
Misawa
M
M
Kasuya
Y
Y
D000818:Animals; D000996:Antitussive Agents / Q000627:therapeutic use*; D002211:Capsaicin / Q000037:antagonists & inhibitors / Q000633:toxicity; D002216:Captopril / Q000627:therapeutic use*; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000627:therapeutic use; D009270:Naloxone / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
D000996:Antitussive Agents; D009270:Naloxone; D009020:Morphine; D002216:Captopril; D002211:Capsaicin