title: Influence of anesthetic regimens on the perioperative catecholamine response associated with onychectomy in cats.
abstract: Plasma catecholamine concentrations in response to onychectomy were examined in 27 cats receiving different anesthetic regimens. Each cat was anesthetized with a dissociative-tranquilizer combination, and onychectomy was performed on 1 forefoot. One week later, each cat was anesthetized with the same dissociative-tranquilizer combination plus either butorphanol or oxymorphone, and onychectomy was performed on the other forefoot. Four treatment groups were studied: tiletamine-zolazepam and tiletamine-zolazepam-butorphanol combinations were administered to group-1 cats, ketamine-acepromazine and ketamine-acepromazine-butorphanol combinations were administered to group-2 cats, tiletamine-zolazepam and tiletamine-zolazepam-oxymorphone combinations were administered to group-3 cats, and ketamine-acepromazine and ketamine-acepromazine-oxymorphone combinations were administered to group-4 cats. All drug combinations were administered IM. Central venous blood samples were drawn for catecholamine analysis after injection of drug(s), after onychectomy, and 1, 2, and 4 hours after injection. Tiletamine-zolazepam alone or tiletamine-zolazepam-butorphanol prevented epinephrine release for 2 hours after injection of drug(s). Norepinephrine concentration increased significantly (P < 0.05) from baseline after onychectomy for tiletamine-zolazepam-butorphanol and at 4 hours for tiletamine-zolazepam and tiletamine-zolazepam-butorphanol. After onychectomy, there was no difference in epinephrine values between tiletamine-zolazepam and tiletamine-zolazepam-oxymorphone. Ketamine-acepromazine prevented increases in norepinephrine and epinephrine concentrations for up to 2 hours after surgery. Addition of butorphanol to ketamine-acepromazine decreased norepinephrine values immediately after onychectomy. Addition of oxymorphone to ketamine-acepromazine resulted in lower epinephrine values 4 hours after surgery.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: G J
authors.initials: GJ
authors.lastname: Benson
authors.forename: J C
authors.initials: JC
authors.lastname: Thurmon
authors.forename: W J
authors.initials: WJ
authors.lastname: Tranquilli
authors.forename: W A
authors.initials: WA
authors.lastname: Olson
authors.forename: R F
authors.initials: RF
authors.lastname: Bevill
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D002077:Butorphanol / Q000494:pharmacology*; D002395:Catecholamines / Q000097:blood*; D002415:Cats / Q000097:blood* / Q000601:surgery*; D005260:Female; D006724:Hoof and Claw / Q000601:surgery*; D008297:Male; D010111:Oxymorphone / Q000494:pharmacology*
chemical_list: D002395:Catecholamines; D010111:Oxymorphone; D002077:Butorphanol