title: Effect of bovine serum albumin on passive transfer of immunoglobulin G1 to newborn calves.
abstract: The molecular mechanism in the intestine of newborn calves that results in transfer of intact colostral immunoglobulin from the lumen to the circulation also is capable of transferring a variety of non-immunoglobulin macromolecules. If the capacity of this mechanism is limited, transfer of a large amount of non-immunoglobulin protein may interfere with transfer of immunoglobulin. In this experiment, efficiency of IgG1 transfer in newborn calves was reduced from 59 to 36% by the addition of bovine serum albumin (37 mg ml-1) to colostral whey, while the addition of a similar mass of amino acids in the form of acid hydrolyzed casein (37 mg ml-1) did not detectably alter IgG1 transfer. Reduced IgG1 absorption efficiency in calves fed colostrum with added bovine serum albumin is consistent with a limited capacity for the macromolecular transport mechanism in the intestine of newborn calves.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
authors.forename: T E
authors.initials: TE
authors.lastname: Besser
authors.forename: D
authors.initials: D
authors.lastname: Osborn
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001693:Biological Transport, Active; D002364:Caseins / Q000276:immunology; D002417:Cattle; D003126:Colostrum / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology*; D007408:Intestinal Absorption / Q000276:immunology; D008297:Male; D011247:Pregnancy; D012710:Serum Albumin, Bovine / Q000276:immunology*
chemical_list: D002364:Caseins; D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine