Stereostructure and NMR characterization of the antibiotic candidin.
The stereostructure of the heptaene macrolide antibiotic candidin was established on the basis of NMR studies: 13C, DQF-COSY, ROESY and C,H-COSY experiments. The absolute configuration of the candidin chiral centers were assigned as 3R, 5S, 10R, 11R, 13R, 15S, 16R, 17S, 19S, 34S, 35R, 36R and 37S.
Pawlak
J
J
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.
Sowiński
P
P
Borowski
E
E
Gariboldi
P
P
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C010428:candidin