title: Effects of alprazolam on cellular immune response to surgical stress in mice.
abstract: Mice exposed to surgical stress induced by laparotomy and treated with chronic alprazolam (0.5-2 mg/kg) showed a dose-dependent reduction in stress-induced suppression of the natural killer (NK) cell activity. These immunoenhancing effects of alprazolam were more intense when it administered before the surgery was performed.
authors.affiliation: Neuroimmunology University of Santiago (NIMUS), Hospital de Conxo, Santiago de Compostela, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Freire-Garabal
authors.forename: M J
authors.initials: MJ
authors.lastname: Núñez
authors.forename: J L
authors.initials: JL
authors.lastname: Balboa
authors.forename: J C
authors.initials: JC
authors.lastname: Fernández-Rial
authors.forename: L G
authors.initials: LG
authors.lastname: Vallejo
authors.forename: J
authors.initials: J
authors.lastname: González-Bahillo
authors.forename: M
authors.initials: M
authors.lastname: Rey-Méndez
mesh_terms: D000525:Alprazolam / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013312:Stress, Physiological / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D013514:Surgical Procedures, Operative / Q000009:adverse effects
chemical_list: D000525:Alprazolam