title: Genetic and environmental effects on preimplantation development of mouse embryo in vitro.
abstract: To examine the degree of the relative contribution of genetic and environmental effects to preimplantation development of mouse embryo in vitro, two-cell stage embryos collected from oviducts of five strains of inbred mice (DDD/Qdj, C3H/Qdj, C57BL/6J Sea, DBA/1J Sea, and BALB/C Sea) were cultivated up to the stage of expanded blastocyst for 72 hr. Both fertility and survival rates were calculated in each recipient and also in each strain. A Student-Newman-Keuls test for both rates showed a significant inter-strain difference and an analysis of variance done to estimate the relative importance of genetic and environmental effects on the preimplantation development of embryo showed a low degree of genetic determination for both rates. It was thus possible to conclude that the environmental effect played a more important role on preimplantation development of mouse embryo in vitro.
authors.affiliation: Department of Pediatric Dentistry, Kyushu University Faculty of Dentistry, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nonaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Yanagita
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: E
authors.initials: E
authors.lastname: Nagata
authors.forename: M
authors.initials: M
authors.lastname: Nakata
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D046508:Culture Techniques; D005314:Embryonic and Fetal Development / Q000235:genetics*; D004777:Environment; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013045:Species Specificity