Immune regulation: learning from leprosy.
The specific anergy seen in severe, disseminated leprosy appears to represent multifaceted actions of macrophages and suppressor T lymphocytes. Identification of cytokine mediation in these events helps to account for the immune system's "choice" of cellular versus humoral defenses--and points toward manipulation of cytokine switches for immunotherapy against infectious and autoimmune disease.
Modlin
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Division of Dermatology, University of California, Los Angeles, School of Medicine.
Bloom
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D016207:Cytokines / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D015440:Leprosy, Lepromatous / Q000276:immunology*; D015441:Leprosy, Tuberculoid / Q000276:immunology* / Q000473:pathology; D009166:Mycobacterium leprae / Q000276:immunology; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines