title: The effect of swelling characteristics of superdisintegrants on the aqueous coating solution penetration into the tablet matrix during the film coating process.
abstract: The mechanism and the extent of sorption of water molecules by tablets containing superdisintegrants and microcrystalline cellulose, following the aqueous film coating of formulated tablets, were investigated. The penetration of water from the coating solution into the tablet matrix resulted in significant changes in physical properties of the coated tablet cores, such as residual moisture content, tensile strength, and pore-size distribution. The swelling and the morphological characteristics of each individual disintegrant compound and microcrystalline cellulose were found to have important implications on the extent of penetration of water from the aqueous film coating solution. A hypothesis concerning the interaction between microcrystalline cellulose and the superdisintegrant particles present in the tablet matrix is proposed.
authors.affiliation: Glaxo Canada Inc., Mississauga, Ontario, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Pourkavoos
authors.forename: G E
authors.initials: GE
authors.lastname: Peck
mesh_terms: D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D013608:Tablets, Enteric-Coated; D013718:Tensile Strength; D014867:Water
chemical_list: D005079:Excipients; D013608:Tablets, Enteric-Coated; D014867:Water; D002482:Cellulose