[Eosinophilic fasciitis (Shulman syndrome) as a rare differential diagnosis of sclerodermiform skin changes].
For 3 months, a 70-year-old woman had been affected by painless, symmetrical swellings in the limbs, spreading proximally, causing hardening of the skin and impaired joint movements, but no fever. Her general condition and findings on physical examination were according to age. ESR was 22/42 mm and there was a thrombocytosis (533,000/microliters) and eosinophilia (16%, absolute 2,140/microliters). Radiological and ultrasound examinations were normal. Skin biopsy revealed marked oedema of the connective tissue septa and perivascular lymphohistiocytic infiltrations, which--together with the other findings--suggested eosinophilic fasciitis. She was treated with prednisone, 100 mg daily, reduced gradually to 8 mg daily, as well as cimetidine, 800 mg daily, as immunomodulator, and intensive physiotherapy. The swellings and eosinophilia regressed within 8 weeks, but the hardening and impaired mobility persisted. Maintenance glucocorticoids are being continued.
Hamm
M
M
Medizinische Klinik II des Krankenhauses Düren.
Rubart
M
M
Behrenbeck
H P
HP
Röttger
P
P
Leonhardt
H
H
D000368:Aged; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications*; D005208:Fasciitis / Q000150:complications*; D005260:Female; D006801:Humans; D012594:Scleroderma, Localized / Q000209:etiology*; D013577:Syndrome
Eosinophile Fasziitis (Shulman-Syndrom) als seltene Differentialdiagnose sklerodermiformer Hautveränderungen.