[Alterations of protein kinase C activity in rat myocardium and aorta smooth muscle during endotoxemia].
A decline of cytosol protein kinase C activity was observed in rat myocardial cells at 4 and 8 h after endotoxin administration, and membrane-associated protein kinase C activity rose at the same time. The activity of membrane protein kinase C in aortic smooth muscle cells at 0.5 and 4 h after endotoxin injection was higher than that in control, while cytosol protein kinase C activity was lower. The results indicate that protein kinase C was activated in myocardial cells and aortic smooth muscle cells during various phases of endotoxemia.
Wei
X
X
Institute of Basic Medical Sciences, Beijing.
D000818:Animals; D001011:Aorta / Q000201:enzymology; D002462:Cell Membrane / Q000201:enzymology; D003593:Cytoplasm / Q000201:enzymology; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000139:chemically induced / Q000201:enzymology*; D014115:Toxemia / Q000201:enzymology
D004731:Endotoxins; D011493:Protein Kinase C