Lipids and lipoproteins of malnourished children during early renutrition: apolipoprotein A-IV as a potential index of recovery.
Twenty-six children with marasmus and 27 with kwashiorkor were compared with 23 control children of matching ages. Kwashiorkor was characterized by increased phospholipids (NS), low (P < 0.01) apolipoprotein (apo) B-rich LDL, and near normal apo A-I and HDL-C. In children with marasmus apo B (P < 0.02) LDL-C (NS), apo A-I (P < 0.01), and HDL-C (P < 0.001) decreased. Fifteen children in each group were followed for 2 wk. Control values were progressively reached after 2 wk. In the younger children final apo B was higher than in control subjects (P < 0.03) but apo A-I was identical. Apo A-IV, assayed because it correlates with the functional state of intestine, was near normal in children with kwashiorkor and decreased with treatment. In children with marasmus apo A-IV decreased by 50%, increased with treatment in older children, but further diminished in younger children. After 2 wk apo A-IV was significantly lower in all patients than in control subjects. Apo A-IV, by remaining depressed after other variables normalized, seems a good index of nutritional status.
el Harim
I
I
Faculté de Médecine et de Pharmacie, Université Mohamed V Laboratoire de Biochimie, Rabat, Morocco.
Befort
J J
JJ
Balafrej
A
A
Lahrichi
M
M
Girard-Globa
A
A
D000293:Adolescent; D000328:Adult; D001054:Apolipoproteins A / Q000032:analysis*; D006801:Humans; D007732:Kwashiorkor / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D009748:Nutrition Disorders / Q000097:blood* / Q000178:diet therapy*; D009747:Nutritional Physiological Phenomena; D011502:Protein-Energy Malnutrition / Q000097:blood
D001054:Apolipoproteins A; D008055:Lipids; D008074:Lipoproteins; C022205:apolipoprotein A-IV