The density of transcriptional elements in promoter and non-promoter sequences.
Using data currently available from transcriptional element (TE) databases, we have analyzed the density of these elements in both promoter and non-promoter sequences obtained from the GenBank sequence database. The density of putative TEs in non-promoter sequences was about 16% higher than that seen in pseudo-random DNA sequences. Promoter TE density from the transcription startsite to 100 basepairs upstream was found to be about 42% higher than in non-promoter sequences. However, the extensive overlap of putative TE densities between promoters and non-promoters confounds an attempt to use TE density as a simple discriminator.
Prestridge
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Theoretical Biology and Biophysics Group, Los Alamos National Labatory, NM 87545.
Burks
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D000465:Algorithms; D004247:DNA / Q000235:genetics; D016208:Databases, Factual; D005809:Genes, Regulator; D006801:Humans; D011401:Promoter Regions, Genetic; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D014157:Transcription Factors; D004247:DNA