MHC haplotype influences primary Giardia muris infections in H-2 congenic strains of mice.
The course of primary Giarda muris infections was studied in H-2 congenic strains of mice on the BALB and C57BL/10 (B10) genetic backgrounds. Infection was curtailed more rapidly in B10 strains, compared with BALB strains, and unaffected by H-2 haplotype. On the other hand the duration of infection in BALB strains did vary with H-2 haplotype with BALB/B(H-2b) mice taking significantly longer to clear infection than BALB/c(H-2d) and BALB/K(H-2k) mice. These experiments demonstrate that both MHC and non-MHC genes influence the outcome of primary G.muris infections.
Venkatesan
P
P
Department of Life Science, University of Nottingham, UK.
Finch
R G
RG
Wakelin
D
D
D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D005873:Giardiasis / Q000276:immunology*; D006183:H-2 Antigens / Q000276:immunology*; D006239:Haplotypes / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
D006183:H-2 Antigens