title: Molecular regulation of the IL-2 gene: rheostatic control of the immune system.
abstract: The delivery of costimulation and the effects of the anergic state impinge on IL-2 production via different molecular mechanisms. The strongest experimental support at this stage suggests that CD28 signaling effects mRNA stability of several lymphokine genes including IL-2. While there may also be transcriptional effects of CD28 signals in human cells, controversy surrounding relevant TCR mimics must be addressed. In the case of clonal anergy, however, transcriptional non-responsiveness is evident when anergic cells are restimulated with TCR and costimulatory signals. This repression affects predominantly AP-1 activity. So far, the nature of the repression has not been identified.
authors.affiliation: Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892.
authors.forename: S W
authors.initials: SW
authors.lastname: Umlauf
authors.forename: B
authors.initials: B
authors.lastname: Beverly
authors.forename: S M
authors.initials: SM
authors.lastname: Kang
authors.forename: K
authors.initials: K
authors.lastname: Brorson
authors.forename: A C
authors.initials: AC
authors.lastname: Tran
authors.forename: R H
authors.initials: RH
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D018106:CD28 Antigens / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007107:Immune System; D007376:Interleukin-2 / Q000235:genetics* / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
chemical_list: D018106:CD28 Antigens; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell