[Effectiveness and safety of 150 mg vs 300 mg ranitidine twice a day in duodenal ulcer].
394 patients with endoscopically diagnosed duodenal ulcer were randomly allocated to treatment with ranitidine 150 bid o ranitidine 300 mg bid in a prospective double-blind multicenter trial conducted in seven LatinoAmerican countries. Endoscopy at 4 weeks showed complete ulcer healing en 171 of 196 patients (87.2%) treated with ranitidine 150 mg bid and 178 of 198 (89.9%) treated with ranitidine 300 mg bid. Both treatment regimens were equally effective at rapidly reducing the incidence of ulcer-related symptoms. It is possible that higher dosage regimen of ranitidine would be useful in patients with more severe duodenal ulcer disease.
Schraier
M
M
Jorge
A
A
Pereyra
J C
JC
Carri
J
J
Padua-Videla
M
M
Hoffenberg
P
P
Villalobos
J
J
Orillac
J
J
Waserstein
M
M
Mendoza
S
S
D000328:Adult; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010176:Panama; D011899:Ranitidine / Q000008:administration & dosage*; D013020:South America
D011899:Ranitidine
Eficacia y seguridad de Ranitidina 150 mg vs 300 mg dos veces por día en ulcera duodenal.