title: Neurolytic superior hypogastric plexus block for chronic pelvic pain associated with cancer.
abstract: Twenty-six patients with extensive gynecologic, colorectal or genitourinary cancer who suffered uncontrolled, incapacitating pelvic pain were enrolled in this study during a 1-year period. All the patients receiving oral opioids who developed poor pain response due to the progression of disease or untoward side effects necessitating other modes of therapy were eligible to participate. Bilateral percutaneous neurolytic superior hypogastric plexus blocks with 10% phenol were performed in every patient, 1 day after receiving successful diagnostic blocks using 0.25% bupivacaine (BUP). All patients reported a visual analog pain score (VAPS) of 10 of 10 before the block. Eighteen patients (69%) had satisfactory pain relief (VAPS < 4 of 10): 15 (57%) after 1 block and 3 (12%) after a second block. The remaining 8 patients (31%) had moderate pain control (VAPS 4-7 of 10) after 2 blocks and received epidural bupivacaine-morphine (BUP-MS) therapy with good results. Both groups experienced significant reductions in oral opioid therapy after the neurolytic blocks. No additional blocks were required by patients who had a good response during a follow-up period of 6 months. No complications related to the block were experienced by any patient. In conclusion, neurolytic superior hypogastric plexus block was both effective in relieving pain in 69% of the patients studied (95% confidence interval of 48-85%). Additional neurolytic blocks using higher volumes of the neurolytic agent may be needed in patients with extensive retroperitoneal disease, a group in whom moderate or poor results should be expected.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, NY 14263 USA.
authors.forename: Oscar A
authors.initials: OA
authors.lastname: de Leon-Casasola
authors.forename: Edward
authors.initials: E
authors.lastname: Kent
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Lema
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007001:Hypogastric Plexus; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D009369:Neoplasms / Q000150:complications*; D009407:Nerve Block / Q000009:adverse effects; D010147:Pain Measurement; D017699:Pelvic Pain / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*
chemical_list: D009020:Morphine