title: Fundus pigmentation and the electroretinographic luminance-response function.
abstract: Dark-adapted and light-adapted electroretinographic luminance-response functions were recorded from subjects with light or dark fundus pigmentation based on digitized fundus photographs. For dark- and light-adapted electroretinograms, subjects with dark fundi had smaller b-wave amplitudes at all luminance levels. There was no significant difference in b-wave implicit time for the dark-adapted electroretinogram, but there was a significant difference for the light-adapted ERG between the two groups. The results suggest that fundus pigmentation should be considered in the interpretation of electroretinogram results. A possible mechanism for the influence of fundus pigmentation on b-wave amplitude is based on increased resistance associated with melanin.
authors.affiliation: Department of Ophthalmology, Columbus Children's Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Wali
authors.forename: L E
authors.initials: LE
authors.lastname: Leguire
mesh_terms: D000328:Adult; D003623:Dark Adaptation; D004596:Electroretinography; D005654:Fundus Oculi; D006801:Humans; D008027:Light; D008543:Melanins / Q000502:physiology; D012160:Retina / Q000502:physiology*; D012168:Retinal Pigments / Q000502:physiology*; D012684:Sensory Thresholds
chemical_list: D008543:Melanins; D012168:Retinal Pigments