title: 99mTc-HMPAO single photon emission tomography in late life depression: a pilot study of regional cerebral blood flow at rest and during a verbal fluency task.
abstract: Relative regional cerebral blood flow (rCBF) was measured at rest and during a verbal fluency task in ten elderly patients with major depressive disorder and nine controls. At rest, depressed patients showed significant reductions in the cortico-cerebellar ratios of tracer uptake in the right and left parietal, left temporal and left occipital regions. During the task relative rCBF increased in patients such that these differences disappeared. Relative rCBF did not correlate with severity of depressed mood or endogenous features but did correlate positively with severity of psychotic symptoms. Frontal relative rCBF correlated negatively with somatic symptoms and anxiety.
authors.affiliation: Department of Psychiatry, Guy's and Lewisham NHS Trust, London, UK.
authors.forename: M P
authors.initials: MP
authors.lastname: Philpot
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.forename: H
authors.initials: H
authors.lastname: Needham-Bennett
authors.forename: D C
authors.initials: DC
authors.lastname: Costa
authors.forename: P J
authors.initials: PJ
authors.lastname: Ell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D003866:Depressive Disorder / Q000000981:diagnostic imaging* / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging* / Q000523:psychology; D015609:Organotechnetium Compounds; D010091:Oximes; D011569:Psychiatric Status Rating Scales; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014705:Verbal Behavior / Q000502:physiology*
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime