Effect of bovine serum albumin on passive transfer of immunoglobulin G1 to newborn calves.
The molecular mechanism in the intestine of newborn calves that results in transfer of intact colostral immunoglobulin from the lumen to the circulation also is capable of transferring a variety of non-immunoglobulin macromolecules. If the capacity of this mechanism is limited, transfer of a large amount of non-immunoglobulin protein may interfere with transfer of immunoglobulin. In this experiment, efficiency of IgG1 transfer in newborn calves was reduced from 59 to 36% by the addition of bovine serum albumin (37 mg ml-1) to colostral whey, while the addition of a similar mass of amino acids in the form of acid hydrolyzed casein (37 mg ml-1) did not detectably alter IgG1 transfer. Reduced IgG1 absorption efficiency in calves fed colostrum with added bovine serum albumin is consistent with a limited capacity for the macromolecular transport mechanism in the intestine of newborn calves.
Besser
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TE
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
Osborn
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D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001693:Biological Transport, Active; D002364:Caseins / Q000276:immunology; D002417:Cattle; D003126:Colostrum / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology*; D007408:Intestinal Absorption / Q000276:immunology; D008297:Male; D011247:Pregnancy; D012710:Serum Albumin, Bovine / Q000276:immunology*
D002364:Caseins; D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine