Effect of mianserin on blood glucose level in rabbits.
Blood glucose level was estimated in 18 h fasted albino rabbits following acute feeding of graded doses of mianserin. Mianserin (6.0 mg/kg) produced a gradually increasing hyperglycemic effect which became significant (P < 0.01) at 10 h and onwards. This appears to be due to increased turnover and release of noradrenaline by the drug. The same dose of mianserin also produced glucose intolerance during early hours probably by interfering with gastrin functions.
Gupta
B
B
Department of Pharmacology, L.L.R.M. Medical College, Meerut.
Shakarwal
M K
MK
Kumar
A
A
Jaju
B P
BP
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000187:drug effects; D006943:Hyperglycemia / Q000139:chemically induced; D008297:Male; D008803:Mianserin / Q000633:toxicity*; D009638:Norepinephrine / Q000378:metabolism; D011817:Rabbits
D001786:Blood Glucose; D008803:Mianserin; D009638:Norepinephrine