[Changes in interleukin-1 released by pulmonary alveolar macrophage in patients with interstitial lung disease].
To evaluate the activity of PAM, levels of IL-1 released by PAM in patients with ILD (non smokers) were measured using lipopolysaccharide (LPS) stimulation and thymocyte proliferation method, healthy non-smokers as control group. The results showed that IL-1 released by PAM in patient groups both with and without LPS stimulation were significantly higher than that in control group, and also IL-1 released by PAM in healthy smokers was significantly higher than that in health non-smokers. It was indicated that IL-1 might play an important role in the process of ILD and chronic pulmonary inflammation.
Li
Z H
ZH
Respiratory Disease Institute, China Medical University.
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000276:immunology*; D017565:Sarcoidosis, Pulmonary / Q000276:immunology
D007375:Interleukin-1