title: The community effect, dorsalization and mesoderm induction.
abstract: The community effect is an interaction among muscle progenitor cells of amphibian gastrula, and is necessary for the initiation of muscle-specific gene expression. Dorsalization provides a signal that can convert ventral mesoderm cells to a muscle fate. Neither process involves mesoderm-inducing molecules. We suggest that the developmental significance of the community effect is to generate homogeneous but clearly demarcated groups of cells from progenitor cells arranged in a continuous gradient of developmental potential.
authors.affiliation: Wellcome CRC Institute, University of Cambridge, UK.
authors.forename: J B
authors.initials: JB
authors.lastname: Gurdon
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: P
authors.initials: P
authors.lastname: Lemaire
mesh_terms: D000818:Animals; D004627:Embryonic Induction; D005775:Gastrula; D008648:Mesoderm; D009132:Muscles / Q000166:cytology / Q000196:embryology*