Molecular weight identification of polyethylene glycols in pharmaceutical preparations by gel permeation chromatography.
The suitability of different Fractogel media [Fractogel TSK HW40(S), Fractogel TSK HW55(F), and Fractogel TSK HW65(F)] for the molecular weight identification of polyethylene glycols was examined. The results were compared with those obtained on two recently introduced gel filtration media (Superdex 75 prep grade and Superdex 200 prep grade); nonspecific adsorptions were observed for the latter. An aqueous gel filtration procedure was developed for the molecular weight identification of polyethylene glycols in drug formulations as an alternative method to that prescribed by the American Pharmacopeia. This procedure was optimized by a logit-log calibration method.
Van Dam
J
J
Catholic University of Louvain (KUL), Department of Toxicology, Leuven, Belgium.
Daenens
P
P
D002850:Chromatography, Gel; D005782:Gels; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000032:analysis* / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared
D005782:Gels; D011092:Polyethylene Glycols