title: Na+,K(+)-ATPase of gastric cells. A target of Helicobacter pylori cytotoxic activity.
abstract: The present study shows a direct impairing action of a cytotoxin-producing Helicobacter pylori strain on the Na+,K(+)-ATPase (evaluated as K(+)-dependent phosphatase activity) of human gastric epithelial cells in culture. The toxin itself is likely involved in this action which may also account for the cell edema found in vivo in Helicobacter pylori-colonized stomach.
authors.affiliation: Institute of Human Physiology, University of Pavia, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Ricci
authors.forename: P
authors.initials: P
authors.lastname: Sommi
authors.forename: E
authors.initials: E
authors.lastname: Cova
authors.forename: R
authors.initials: R
authors.lastname: Fiocca
authors.forename: M
authors.initials: M
authors.lastname: Romano
authors.forename: K J
authors.initials: KJ
authors.lastname: Ivey
authors.forename: E
authors.initials: E
authors.lastname: Solcia
authors.forename: U
authors.initials: U
authors.lastname: Ventura
mesh_terms: D000230:Adenocarcinoma; D001427:Bacterial Toxins / Q000633:toxicity*; D002460:Cell Line; D004848:Epithelium / Q000201:enzymology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013270:Stomach / Q000382:microbiology*; D013274:Stomach Neoplasms; D014407:Tumor Cells, Cultured
chemical_list: D001427:Bacterial Toxins; D000254:Sodium-Potassium-Exchanging ATPase