[Status of the antioxidant system and sorbitol pathway of glucose metabolism in diabetes mellitus].
It is found that antioxidative activity (AOA) and activity of glutathione-transferase in postmitochondrial placenta fraction of pregnant women with diabetes mellitus is lowered. Depression of AOA in placenta associated with a decrease of UDA and ceruloplasmin amount in blood of the newborns shows the exhaustion of the antioxidative protection system. A decrease of enzyme activity at the sorbitol way of glucose exchange (sorbitol-dehydrogenase and aldose reductase) in placenta reflects accumulation of sorbitol in tissue, which intensifies the damage of membrane structures in placenta.
Zakrevskiĭ
A A
AA
Osinskaia
L F
LF
Znamenskaia
T K
TK
Kurilina
T V
TV
Martynenko
L G
LG
D000449:Aldehyde Reductase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D010084:Oxidation-Reduction; D010920:Placenta / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D011379:Prognosis; D013012:Sorbitol / Q000378:metabolism*
D013012:Sorbitol; D007064:L-Iditol 2-Dehydrogenase; D000449:Aldehyde Reductase; D002570:Ceruloplasmin; D005982:Glutathione Transferase; D005947:Glucose
Sostoianie antiokislitel'noĭ sistemy i sorbitolovogo puti metabolizma gliukozy pri sakharnom diabete.