Induction of B cell tumor dormancy by anti-idiotypic antibodies.
Long-term dormancy of murine B-cell lymphomas can be experimentally induced by immunizing the host with the idiotype expressed on the tumor. Interaction of the cells with anti-idiotype antibodies is sufficient to induce and maintain the dormant state. The growth of lymphoma cells interacting with anti-idiotype antibodies is arrested and they undergo dramatic changes in their morphology, cell-cycle status and oncogene expression. Regrowth of a tumor after long-term dormancy results from the emergence of a tumor cell variant that no longer responds to the antibodies with growth inhibition. These data demonstrate the feasibility of reversing a malignant phenotype of cells by specific growth arrest signals and suggest new approaches for therapeutic intervention in cancer.
Yefenof
E
E
Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel.
Picker
L J
LJ
Scheuermann
R H
RH
Vitetta
E S
ES
Street
N E
NE
Tucker
T F
TF
Uhr
J W
JW
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D000912:Antibodies, Neoplasm / Q000627:therapeutic use; D002453:Cell Cycle; D002455:Cell Division; D007114:Immunization; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D012074:Remission Induction
D000888:Antibodies, Anti-Idiotypic; D000912:Antibodies, Neoplasm