title: Liposarcoma in patients younger than or equal to 22 years of age.
abstract: BACKGROUND
  There have been few reported series of liposarcomas in patients younger than or equal to 22 years of age.
  
  
  METHODS
  A retrospective analysis of all patients presenting with liposarcoma between 1949-1990 at Memorial Sloan-Kettering Cancer Center with age at diagnosis younger than or equal to 22 years was performed. Variables evaluated for their predictive effect on survival included anatomic location of the primary, size, and completeness of surgical resection.
  
  
  RESULTS
  Eighteen patients were identified. Only 1 patient (6%) presented with a high-grade lesion, and in 13 patients (72%), the myxoid subtype was observed. All but one patient undergoing complete resection remain disease-free 1.3-29.1 years after treatment, while all patients with gross residual tumor have died from disease. Two of three patients with microscopic residual at resection are disease-free 2 and 11.8 years after diagnosis with the addition of external beam radiation therapy.
  
  
  CONCLUSIONS
  The authors conclude that complete surgical resection is crucial for survival in young patients with liposarcoma and the external beam radiation therapy may be effective against microscopic residual.
authors.affiliation: Department of Surgery (Pediatric Surgery), Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: M P
authors.initials: MP
authors.lastname: La Quaglia
authors.forename: S A
authors.initials: SA
authors.lastname: Spiro
authors.forename: F
authors.initials: F
authors.lastname: Ghavimi
authors.forename: S I
authors.initials: SI
authors.lastname: Hajdu
authors.forename: P
authors.initials: P
authors.lastname: Meyers
authors.forename: P R
authors.initials: PR
authors.lastname: Exelby
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D008080:Liposarcoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D013848:Thigh