Role of prostaglandins in exercise-induced core temperature elevation in female Sprague-Dawley rats.
Female Sprague-Dawley rats (12:12-h photoperiod; body temperature, BT, measured with biotelemetry) with access to running wheels for 6 wk have an elevated BT (compared with rats with no access to exercise wheels, i.e, sedentary) both during the period of voluntary exercise (nighttime) (0.5 degree C, P = 0.0001) and the nonexercise period (daytime) (0.3 degree C, P = 0.002). To determine whether prostaglandin (PG) E was responsible for any portion of this daytime rise in BT, we injected a dose of sodium salicylate (300 mg/kg), which was shown to produce complete antipyresis in rats injected with lipopolysaccharide (LPS), into exercised and sedentary rats 4 h after the onset of the lights-on period. The injections of sodium salicylate led to a fall in body temperature in both the exercised and sedentary rats of similar amounts (-0.88 degree C vs. -0.61 degree C at 2 h postinjection, P = 0.59). We conclude that the increase in daytime BT of exercised female rats is not mediated by prostaglandins.
Rowsey
P J
PJ
Division of Kinesiology, University of Michigan, Ann Arbor 48109.
Borer
K T
KT
Kluger
M J
MJ
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation; D002940:Circadian Rhythm; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010805:Physical Conditioning, Animal; D005082:Physical Exertion; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012980:Sodium Salicylate / Q000494:pharmacology
D004731:Endotoxins; D008070:Lipopolysaccharides; D012980:Sodium Salicylate