Bromocriptine-induced dystonia in patients with aphasia and hemiparesis.
Five of seven patients with chronic nonfluent aphasia and hemiparesis due to a focal ischemic infarction developed painful hemidystonia during treatment with a high dose of bromocriptine. All seven patients had cortical damage, but four also had basal ganglia and one thalamic involvement. While lesion location did not differ between dystonic and nondystonic patients, the dystonic patients had more weakness than those without dystonia.
Leiguarda
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Raúl Carrea Institute of Neurological Research, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina.
Merello
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M
Sabe
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Starkstein
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S
D000328:Adult; D000368:Aged; D001037:Aphasia / Q000150:complications* / Q000188:drug therapy; D001921:Brain / Q000000981:diagnostic imaging; D001971:Bromocriptine / Q000009:adverse effects*; D004421:Dystonia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006429:Hemiplegia / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D001971:Bromocriptine