title: Effects of fenvalerate and esfenvalerate on hepatic gap junctional intercellular communication in rats.
abstract: Effects of in vivo exposure with fenvalerate, esfenvalerate and DDT on hepatic gap junctional intercellular communication (GJIC) in Sprague-Dawley (SD) rats were examined by in vivo/in vitro dye-transfer assay and by immunohistochemical staining of connexin 32 (Cx32, major liver gap junction protein). Fenvalerate (75 mg/kg/day), esfenvalerate (25 mg/kg/day), DDT (50 mg/kg/day) and corn oil (vehicle control, 5 ml/kg/day) were administered orally once a day. Animals were killed at weeks 1, 2, 4 and 6 after starting the experiment. In the fenvalerate- and esfenvalerate-groups, no compound-related changes in GJIC and Cx32 expression were observed. On the contrary, in the DDT-group, average sizes of the dye spread after injection of Lucifer Yellow decreased at weeks 1, 2 and 4, and the area per GJ spot shown by Cx32-immunohistochemical staining decreased at weeks 4 and 6. It is concluded that neither fenvalerate nor esfenvalerate inhibits hepatic GJIC with in vivo exposure.
authors.affiliation: Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: C
authors.initials: C
authors.lastname: Tateno
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Yoshitake
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D003634:DDT / Q000494:pharmacology; D005456:Fluorescent Dyes; D017629:Gap Junctions / Q000187:drug effects*; D007150:Immunohistochemistry; D007546:Isoquinolines; D008099:Liver / Q000187:drug effects*; D008297:Male; D009570:Nitriles; D011722:Pyrethrins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005456:Fluorescent Dyes; D007546:Isoquinolines; D009570:Nitriles; D011722:Pyrethrins; C017475:lucifer yellow; D003634:DDT; C017690:fenvalerate