[Tissue diffusion of amoxicillin-clavulanic acid for antibiotic prophylaxis in colorectal surgery].
Tissue penetration of amoxicillin and clavulanic acid given for antibiotic prophylaxis was studied in 15 patients. On induction of anesthesia patients were given 2 g amoxicillin and 200 mg clavulanic acid. The same dose was given two hours later. At time of surgical incision amoxicillin and clavulanate levels were 15.9 +/- 7.7 micrograms/g and 2.23 +/- 2.69 micrograms/g in abdominal wall fat and 16.6 +/- 10.5 and 1.72 +/- 1.35 micrograms/g in epiploic fat, respectively. Similar levels were measured at time of closure of the abdomen. In colonic wall, amoxicillin et clavulanate levels were 22.7 +/- 13.4 micrograms/g and 2.65 +/- 2.35 micrograms/g. By comparison with blood levels, tissue penetration of both drugs was 20 to 30 p. cent into fatty tissues and 60 to 70 p. cent into colonic wall.
Martin
C
C
Département d'Anesthésie-Réanimation, Hôpital Nord, Marseille, France.
Mallet
N M
NM
Viviand
X
X
Ruperti
A
A
Martin
A
A
de Micco
P
P
Sastre
B
B
Gouin
F
F
D000273:Adipose Tissue / Q000187:drug effects; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D001442:Bacteroides Infections / Q000517:prevention & control*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000601:surgery; D003106:Colon / Q000187:drug effects / Q000382:microbiology; D015179:Colorectal Neoplasms / Q000601:surgery*; D004058:Diffusion; D004238:Diverticulitis / Q000601:surgery; D004927:Escherichia coli Infections / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012007:Rectum / Q000382:microbiology / Q000601:surgery; D012810:Sigmoid Diseases / Q000601:surgery; D013203:Staphylococcal Infections / Q000517:prevention & control*
D002969:Clavulanic Acids; D019818:Clavulanic Acid; D000658:Amoxicillin
Diffusion tissulaire de l'amoxicilline-acide clavulanique pour une antibioprophylaxie en chirurgie colorectale.