Renal elimination of some 99mTc-labelled cysteamine derivatives.
It is generally believed that -CO-NH-(CH2)n-COOH moiety promotes tubular excretion of organic anions. Recently it was reported that newly developed renal agents, containing the oxotechnetium(V) glycine group, may mimic the carbonyl amide sequence of [131]I-o-iodohippuric acid. In this study the renal excretion of certain carboxy-cysteamine derivatives is investigated in mice, in the presence of renal tubular transport inhibitor. A similar pattern of renal depression was observed for complexes containing the oxotechnetium glycine sequence, suggesting that this group may satisfy structural parameters for tubular secretion of anionic technetium complexes.
Mansur
S
S
PINSTECH, Islamabad, Pakistan.
Jehangir
M
M
Stathaki
S
S
Papadopoulos
M
M
Mastrostamatis
S
S
Chiotellis
E
E
D000818:Animals; D003543:Cysteamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D013667:Technetium
D003543:Cysteamine; D013667:Technetium