The beta A4 amyloid protein precursor in human circulation.
beta A4, the principal constituent of the brain amyloid collections in Alzheimer's disease, is derived from a much larger precursor, the amyloid protein precursor (APP). APP exists in the blood as full-length, potentially amyloidogenic forms in platelets, and as an attenuated species in plasma and T-lymphocytes. Studies of circulating APP facilitate the elaboration of the function of this protein, as well as the elucidation of its processing in health and disease.
Bush
A I
AI
Department of Pathology, University of Melbourne, Victoria Australia.
Beyreuther
K
K
Masters
C L
CL
D000544:Alzheimer Disease / Q000097:blood / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000096:biosynthesis / Q000097:blood*; D016564:Amyloid beta-Protein Precursor / Q000097:blood* / Q000378:metabolism; D000686:Amyloidosis / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D004314:Down Syndrome / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor