Myeloperoxidase-mediated activation of xenobiotics by human leukocytes.
Peripheral blood leukocytes contain a variety of enzymes that are capable of metabolising xenobiotics. The enzyme myeloperoxidase (MPO) appears to be the most important for drug metabolism. MPO is a peroxidase/oxidase and generates the powerful oxidant hypochlorous acid. MPO- or MPO-generated oxidants are capable of oxidizing a wide variety of compounds and a broad range of functional groups, especially those that contain nitrogen and sulfur. Leukocytes have a role in immune response; therefore, reactive intermediates generated by leukocyte metabolism of xenobiotics may have a role in idiosyncratic drug reactions, particularly those that are immune-mediated such as drug-induced lupus or agranulocytosis.
Hofstra
A H
AH
Faculty of Pharmacy, University of Toronto, Ontario, Canada.
Uetrecht
J P
JP
D001711:Biotransformation; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism / Q000493:pharmacokinetics*
D015262:Xenobiotics; D009195:Peroxidase