The alpha study: multiple regression of the inositol 1,4,5-triphosphate signal transduction mechanism in burn trauma.
The novelty of applying 3-dimensional graphic capabilities, involving area and vector changes was used to understand variations in inositol derivatives due to the systemic effects of large body surface area (BSA) burns. This report is an attempt to broaden current perspectives on how such changes in inositol forms impact on the disposition of IP3 within skeletal muscle cells. Because it is the first of its type to evaluate systemic effects in this way, it is called the alpha study. Consideration of multiple factors (viz., 5 orders of magnitude) involved in burn trauma in this manner provides new insight into the pharmacologic changes which utilize the IP3 signal transducing system that underlie burn trauma. Such insight would prove beneficial in improving the quality of rehabilitative burn care with respect to skeletal muscle physiology.
Tomera
J F
JF
Clinical Pharmacology Laboratory, Shriners Burns Institute, Boston, MA.
Lilford
K
K
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D007293:Inosine Triphosphate / Q000502:physiology*; D007295:Inositol Phosphates / Q000378:metabolism; D008297:Male; D051379:Mice; D008954:Models, Biological; D015999:Multivariate Analysis; D012044:Regression Analysis; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D007295:Inositol Phosphates; D007293:Inosine Triphosphate