title: Enantioselectivity of esterases in human brain.
abstract: Subcellular fractions of three human brain specimens were found to contain esterase activities which hydrolyzed racemic oxazepam 3-acetate (rac-OXA). All three human brain preparations were highly selective toward the S-enantiomer of rac-OXA.
authors.affiliation: Department of Pharmacology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors.forename: S K
authors.initials: SK
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Huang
authors.forename: J D
authors.initials: JD
authors.lastname: Huang
mesh_terms: D000328:Adult; D001921:Brain / Q000201:enzymology*; D002648:Child; D004950:Esterases / Q000378:metabolism*; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D008297:Male; D010076:Oxazepam / Q000031:analogs & derivatives* / Q000378:metabolism; D013237:Stereoisomerism; D013347:Subcellular Fractions; D013379:Substrate Specificity
chemical_list: C028246:oxazepam acetate; D010076:Oxazepam; D004950:Esterases