Phenazoviridin, a novel free radical scavenger from Streptomyces sp. Taxonomy, fermentation, isolation, structure elucidation and biological properties.
Phenazoviridin is a newly discovered free radical scavenger from microorganisms. It was isolated from the culture of Streptomyces sp. HR04. The structure of phenazoviridin was determined as 6-(3-methyl-2-butenyl)phenazine-1-carboxylic acid 6-deoxy-alpha-L-talopyranose ester on the basis of its spectroscopic and physico-chemical properties. The novel substance showed strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibited antihypoxic activity in mice.
Kato
S
S
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Shindo
K
K
Yamagishi
Y
Y
Matsuoka
M
M
Kawai
H
H
Mochizuki
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005285:Fermentation; D016166:Free Radical Scavengers; D006601:Hexoses / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011190:Potassium Cyanide / Q000037:antagonists & inhibitors / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013302:Streptomyces / Q000737:chemistry*
D016166:Free Radical Scavengers; D006601:Hexoses; D010619:Phenazines; C084384:phenazoviridin; D011190:Potassium Cyanide