Therapy-related myelodysplastic syndrome. Two cytogenetically unrelated abnormal clones in a patient with multiple myeloma.
A multiple myeloma patient presented for cytogenetic analysis at diagnosis of secondary MDS, which followed cytotoxic treatment including melphalan. Two abnormal unrelated clones were detected, one of them had 5q-, 7q- with clonal evolution of an additional aberration, t(12;13); in the second clone there was a translocation between the two homologues of chromosome 1 as the only aberration. We suggest that the clone with 5q- and 7q- represented the secondary MDS cells, whereas the abnormal clone with t(1;1) represented the plasmablasts of the multiple myeloma.
Abeliovich
D
D
Department of Human Genetics, Mount Scopus, Hadassah University Hospital, Jerusalem, Israel.
Yehuda
O
O
Ben-Neriah
S
S
Matzner
Y
Y
D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002882:Chromosomes, Human, Pair 13; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D008297:Male; D008558:Melphalan / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics*; D014178:Translocation, Genetic
D008558:Melphalan