title: Neurobehavioral functions among workers exposed to manganese ore.
abstract: The Neurobehavioral Core Test Battery of the World Health Organization was performed on 17 baggers (mean age 36.6 years) in a manganese ore milling plant and 17 referents (mean age 35.7 years). The baggers had a mean exposure period of 7.4 (range 1-14) years with a mean blood manganese concentration of 25.3 (range 15-92.5) micrograms.l-1 [0.46 (0.27-1.68) mumol.l-1]. Of the 37 symptoms related to the nervous system, 20 were more frequently reported by the exposed workers. No significant differences were noted between the nerve conduction of the median and ulnar nerves of the dominant forearm of the two groups. The exposed workers had significantly poorer motor speed, visual scanning, visuomotor coordination, visuomotor and response speed, and visuomotor coordination and steadiness. A clinical examination did not reveal any abnormality among the two groups. Hence a neurobehavioral test battery may be a more sensitive method than a clinical examination in detecting early changes in motor function among manganese-exposed workers.
authors.affiliation: Department of Community, Occupational & Family Medicine, National University of Singapore.
authors.forename: S E
authors.initials: SE
authors.lastname: Chia
authors.forename: S C
authors.initials: SC
authors.lastname: Foo
authors.forename: S L
authors.initials: SL
authors.lastname: Gan
authors.forename: J
authors.initials: J
authors.lastname: Jeyaratnam
authors.forename: C S
authors.initials: CS
authors.lastname: Tian
mesh_terms: D000328:Adult; D004784:Environmental Monitoring; D006801:Humans; D008297:Male; D008345:Manganese / Q000009:adverse effects* / Q000493:pharmacokinetics; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D009460:Neurologic Examination / Q000187:drug effects; D009483:Neuropsychological Tests; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D016273:Occupational Exposure / Q000009:adverse effects; D019966:Substance-Related Disorders / Q000175:diagnosis*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D008345:Manganese