Serum thyrotropin responses to thyrotropin-releasing hormone in Korsakoff's syndrome.
Eleven patients with DSM-III-R Korsakoff's syndrome were studied as were 11 patients with alcohol dependence syndrome (without Korsakoff's syndrome and abstinent for at least 3 years) and 11 healthy controls. All subjects underwent a thyroid-releasing hormone and thyroid-stimulating hormone stimulation test. Forty-five percent of the Korsakoff's syndrome patients had a blunted response and 18% of the chronic abstinent alcoholic group were similarly blunted. None of the controls had an attenuated response. The possible reasons for the high level of blunting are discussed.
Thakore
J H
JH
Department of Psychological Medicine, St. Bartholomew's Hospital, London, United Kingdom.
Dinan
T G
TG
D000425:Alcohol Amnestic Disorder / Q000097:blood / Q000175:diagnosis* / Q000534:rehabilitation; D000437:Alcoholism / Q000097:blood / Q000175:diagnosis* / Q000534:rehabilitation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013695:Temperance; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin