title: Omission of temporary diversion in restorative proctocolectomy--is it safe?
abstract: OBJECTIVE
  The aim of our study was to evaluate the safety and functional outcome of restorative proctocolectomy (RP) without diversion.
  
  
  METHODS
  Fifty patients underwent RP without diversion for ulcerative colitis (82 percent), familial adenomatous polyposis (12 percent), and indeterminate colitis (6 percent). The perioperative course and functional outcome of these patients were compared with another group of 50 patients undergoing RP with diverting ileostomy during the same time period (1989-1991) and closely matched for age, gender, surgeon, diagnosis, extent and duration (median, 10 years) of colitis, prior colectomy (approximately 22 percent), steroid use (40 percent), type of pouch, distance of ileal pouch-anal anastomosis from the dentate line (median, 1.5 cm), and the duration of follow-up (median, 12 months). All patients had a stapled ileal pouch-anal anastomosis without mucosectomy and a smooth conduct of the operation.
  
  
  RESULTS
  There was no operative mortality. Anastomotic leaks and pelvic abscess were more common in patients without ileostomy (7/50 or 14 percent vs. 2/50 or 4 percent); 8 of these 9 patients were taking > or = 20 mg of prednisone/day. Septic complications requiring relaparotomy (6 percent vs. 0 percent), prolonged ileus, and fever of unknown origin (10 percent vs. 4 percent) were also more common in patients without ileostomy. Despite similar functional results at 6 weeks and at 12 months after initial pouch function, patients without ileostomy had a poorer quality of life index (5 vs. 8; 10 being best) in the early period (0-6 weeks) of pouch function.
  
  
  CONCLUSIONS
  In equally favorable cases, RP without diversion is not as safe as RP with diversion, especially in patients taking > or = 20 mg of prednisone/day.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195.
authors.forename: J J
authors.initials: JJ
authors.lastname: Tjandra
authors.forename: V W
authors.initials: VW
authors.lastname: Fazio
authors.forename: J W
authors.initials: JW
authors.lastname: Milsom
authors.forename: I C
authors.initials: IC
authors.lastname: Lavery
authors.forename: J R
authors.initials: JR
authors.lastname: Oakley
authors.forename: J M
authors.initials: JM
authors.lastname: Fabre
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003092:Colitis / Q000601:surgery; D003093:Colitis, Ulcerative / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000601:surgery*; D011241:Prednisone / Q000627:therapeutic use; D011292:Premedication; D016737:Proctocolectomy, Restorative; D012086:Reoperation; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011241:Prednisone