title: Effects of carbamazepine on action potentials and calcium currents in rat spinal ganglion cells in vitro.
abstract: The effects of carbamazepine (CBZ) on action potentials and calcium currents in cultured rat sensory spinal ganglion cells were investigated. CBZ was found to reversibly suppress the calcium-dependent components of action potentials and to reduce the amplitude of the after-hyperpolarizations, while the rising phase and the peak amplitude were hardly changed. Furthermore, CBZ caused a marked reduction in the calcium currents, which in some cells was reversible. The present findings confirm that CBZ has calcium-antagonistic properties.
authors.affiliation: Institut für Physiologie, Universitäts-GHS-Essen, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Schirrmacher
authors.forename: A
authors.initials: A
authors.lastname: Mayer
authors.forename: J
authors.initials: J
authors.lastname: Walden
authors.forename: R
authors.initials: R
authors.lastname: Düsing
authors.forename: D
authors.initials: D
authors.lastname: Bingmann
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D002220:Carbamazepine / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D051381:Rats
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002220:Carbamazepine