A reappraisal of the carcinogenicity of surface modified asbestos fibres.
A previous study using intrapleural administration of surface-modified amosite asbestos showed a difference in the number of pleural mesotheliomas induced with C18-hydrocarbon derivatised fibres compared to native amosite asbestos. The study has been repeated with larger groups of animals (30) under specific pathogen free conditions, resulting in an increase in the mean animal survival time for both fibre-treated groups. Under these conditions there was no significant difference between the numbers of pleural mesotheliomas induced by C18 hydrocarbon-modified amosite asbestos and native amosite asbestos. The major difference between the two studies was the mean time to death from tumour of rats exposed to fibres. The C18 amosite treated rats in the first study may not have had a mean survival time long enough to allow mesotheliomas to develop.
Carthew
P
P
MRC Toxicology Unit, University of Leicester, UK.
Edwards
R E
RE
Dorman
B M
BM
Brown
R C
RC
Hoskins
J A
JA
Simpson
C F
CF
D000818:Animals; D017639:Asbestos, Amosite / Q000633:toxicity*; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced* / Q000473:pathology; D010997:Pleural Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012821:Silanes / Q000633:toxicity*; D013997:Time Factors
D012821:Silanes; C084489:octadecyldimethylchlorosilane-modified amosite; D017639:Asbestos, Amosite