title: The cellular basis of Fanconi syndrome.
abstract: In this syndrome, all solutes are prevented from crossing the apical membrane of the proximal renal tubule cell; hence, investigations have focused on generalized transport dysfunction, namely intracellular ATP activity. Experiments suggest that intracellular adenine nucleotide degradation secondary to phosphate depletion causes a decline in ATP.
authors.affiliation: Division of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas.
authors.forename: M
authors.initials: M
authors.lastname: Baum
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D005198:Fanconi Syndrome / Q000209:etiology / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000503:physiopathology*; D010710:Phosphates / Q000172:deficiency / Q000502:physiology
chemical_list: D010710:Phosphates; D000255:Adenosine Triphosphate