[Oxygen-dependent processes in the liver and immunologic reactivity of rats in chronic liver damage induced by carbon tetrachloride].
The chronic hepatitis in Wistar rats was induced by seven subcutaneous injections of carbon tetrachloride (0.3 ml of 50% oil solution per 1 kg of body mass) made each third day. It was shown that cytochromes P-450 and b5 content, demethylase activity in the liver microsomal fraction as well as the oxygen tension in the liver tissue were decreased, while lipid peroxidation was intensified. The PHA-induced blood lymphocyte blastogenesis was inhibited and concentration of circulating immune complexes in the blood was higher than that in intact animals.
Alekseeva
I N
IN
Bryzgina
T M
TM
Pavlovich
S I
SI
Nosar
V I
VI
Aleksiuk
L I
LI
Makogon
N V
NV
Gotsuliak
Ia N
IaN
Martynova
T V
TV
Sidorenko
O V
OV
Sukhina
V S
VS
D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D002908:Chronic Disease; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism*; D006388:Hemagglutinins; D007279:Injections, Subcutaneous; D015227:Lipid Peroxidation; D008213:Lymphocyte Activation; D008862:Microsomes, Liver / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000276:immunology*
D006388:Hemagglutinins; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D010088:Oxidoreductases
Kislorodzavisimye protsessy v pecheni i immunologicheskaia reaktivnost organizma krys pri khronicheskom porazhenii pecheni chetyrkhkhloristymuglerodom.