Pseudotumor cerebri induced by vitamin A combined with minocycline.
A 16-year-old girl complained about a headache of one-month's duration, accompanied by vertical diplopia that had appeared ten days earlier. The girl reported receiving vitamin A and minocycline to treat acne vulgaris for the previous six weeks. An examination revealed bilateral optic disc edema. Normal computed tomographic and magnetic resonance imaging examinations enabled a diagnosis of pseudotumor cerebri to be made. Soon after discontinuation of those medications, the headaches and diplopia diminished. We suggest a periodic ophthalmologic examination during systemic therapy with vitamin A combined with minocycline to detect the early occurrence of pseudotumor cerebri.
Moskowitz
Y
Y
Department of Ophthalmology, Barzilai Medical Center, Ashkelon, Israel.
Leibowitz
E
E
Ronen
M
M
Aviel
E
E
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D004172:Diplopia / Q000139:chemically induced; D004359:Drug Therapy, Combination; D005260:Female; D005654:Fundus Oculi; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008279:Magnetic Resonance Imaging; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D010211:Papilledema / Q000139:chemically induced; D011559:Pseudotumor Cerebri / Q000139:chemically induced* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D014801:Vitamin A / Q000009:adverse effects* / Q000627:therapeutic use
D014801:Vitamin A; D008911:Minocycline