title: t(8;21) prior to acute leukemia.
abstract: A t(8;21)(q22;q22) without blood and bone marrow invasion by immature myeloid precursor cells occurred in a patient previously treated for polycythemia vera. The presence of a molecular rearrangement confirmed that the chromosomal abnormality was identical to that observed in acute leukemia with t(8;21). This case shows that the translocation, t(8;21), may occur in myelodysplasia and suggests that it can precede the appearance of overt leukemia.
authors.affiliation: INSERM U 301, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: J
authors.initials: J
authors.lastname: Hillion
authors.forename: D
authors.initials: D
authors.lastname: Janvier
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Bussel
mesh_terms: D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D007964:Leukocytosis / Q000209:etiology / Q000235:genetics; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D011289:Preleukemia / Q000209:etiology / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D006918:Hydroxyurea