title: Reversal of diastolic dysfunction by intravenous magnesium chloride.
abstract: OBJECTIVE
  To treat diastolic dysfunction in patients with coronary artery disease (CAD).
  
  
  METHODS
  Open study of the intravenous injection of 5 mL of a solution containing 17% magnesium chloride (equal to 100 mg of elemental magnesium) during routine coronary angiography in patients with a raised left ventricular end-diastolic pressure (LVEDP).
  
  
  METHODS
  A hospital department of cardiac hemodynamics.
  
  
  METHODS
  Ten patients with angiographically documented CAD.
  
  
  RESULTS
  After magnesium chloride injection, the LVEDP was significantly reduced in all patients, from a mean of 24 +/- 3 to 16 +/- 3 mmHg (P < 0.001).
  
  
  CONCLUSIONS
  Under the short term conditions of the study, the injection of magnesium chloride effectively improved left ventricular diastolic function. Further study of the long term effect is required.
authors.forename: F
authors.initials: F
authors.lastname: Kraus
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects*; D005260:Female; D006801:Humans; D015636:Magnesium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D015636:Magnesium Chloride