[The antiviral action of medicinal plant extracts in experimental tick-borne encephalitis].
Some mechanisms of inducing resistance to experimental infection with tick-borne encephalitis virus were studied in experimental mice treated with aqueous extracts of berries of Vaccinium vitis-idaea, black currant, Vaccinium myrtillus, and of greater celandine grass. The condition of the immune system organs (spleen and thymus) after treatment with the extracts under study was analysed. A correlation was found between the degree of developing resistance to infection, virus accumulation in the brain, blood, spleen and thymus and changes in some parameters (spleen and thymus indices) of these immunocompetent organs. Possible mechanisms of induction of resistance to virus by herb extracts are discussed.
Fokina
G I
GI
Roĭkhel'
V M
VM
Frolova
M P
MP
Frolova
T V
TV
Pogodina
V V
VV
D000818:Animals; D000998:Antiviral Agents / Q000032:analysis / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000032:analysis / Q000627:therapeutic use*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D013997:Time Factors
D000998:Antiviral Agents; D010936:Plant Extracts
Protivovirusnoe deĭstvie ékstraktov lekarstvennykh rasteniĭ pri éksperimental'nom kleshchevom éntsefalite.