[The relation between the volume of gastric mucosal blood flow and acid secretion in patients with gastric and duodenal ulcer].
The relationship between gastric mucosal blood flow and acid secretion was studied in 39 patients. In the active stage of gastric ulcer, the volume of gastric mucosal blood flow (GMBF) was decreased, and that of GMBF at the ulcer margin was decreased significantly and increased markedly at the healing stage. The volume of gastric acid output showed no significant difference between the patients with gastric ulcer and controls. The volume of GMBF was slightly increased at all stages of duodenal ulcer. The volume of gastric acid output was increased in the patients with duodenal ulcer. A positive relationship was noted between the volume of maximal acid output and GMBF in the patients with duodenal ulcer. The results indicated that there is a great difference between gastric ulcer and duodenal ulcer in the functions of mucosal microcirculation and acid secretion cells. The reduction of mucosal protective function may be attributable to the pathogenesis of gastric ulcer. The strengthening of the injury factors plays an important role in causing duodenal ulcer. Increased mucosal blood supply may promote the healing of the ulcer.
Sun
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Department of Surgery, Second Teaching Hospital, Tianjin Medical College.
D000328:Adult; D000368:Aged; D001810:Blood Volume; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D013276:Stomach Ulcer / Q000503:physiopathology*