title: Tuberculosis and HIV infection: epidemiology, pathogenesis, and clinical aspects.
abstract: Human immunodeficiency virus infection has profoundly affected the epidemiology, natural history, and clinical presentation of TB. It has also contributed in part to the recent epidemic of MDR-TB in the US and significantly reduced the sensitivity (but not the specificity) of the tuberculin skin test. Further research is needed to determine the optimal strategy for chemoprophylaxis in HIV-infected individuals, new methods of diagnosing TB infection and disease, and new drugs to control MDR-TB. Most importantly, however, further funding is necessary to improve compliance with therapy and chemoprophylaxis in order to regain control of this ancient scourge.
authors.affiliation: Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health.
authors.forename: N M
authors.initials: NM
authors.lastname: Graham
authors.forename: R E
authors.initials: RE
authors.lastname: Chaisson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D000328:Adult; D006801:Humans; D015994:Incidence; D014376:Tuberculosis / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology