Photochemical cleavage of DNA by phosphorus(V) porphyrin derivatives.
Photocleavages of double-stranded circular DNA and oligonucleotide were investigated by the use of phosphorus(V)tetraphenylporphyrin (P(V)TPP) derivatives. The P(V)TPP derivatives cleaved the DNA and the oligonucleotide under the visible light irradiation, in air and in argon, respectively. It is suggested that the photocleavage reactions include an electron transfer mechanism as well as a singlet oxygen (1O2) one.
Saito
T
T
Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Japan.
Kitamura
M
M
Tanaka
M
M
Morimoto
M
M
Segawa
H
H
Shimidzu
T
T
D010584:Bacteriophage phi X 174 / Q000235:genetics; D001483:Base Sequence; D004279:DNA, Viral / Q000737:chemistry*; D005026:Ethylene Glycols / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D009843:Oligoribonucleotides / Q000737:chemistry*; D010777:Photochemistry; D011166:Porphyrins / Q000737:chemistry*; D017382:Reactive Oxygen Species
D004279:DNA, Viral; D005026:Ethylene Glycols; D009843:Oligoribonucleotides; D011166:Porphyrins; D017382:Reactive Oxygen Species; C084410:bis(hydroxyethyloxy)phosphorus(V)tetraphenylporphyrin; C084411:bis(3'-5'-decathymidylyl)phosphorus(V)tetraphenylporphyrin