title: Ofloxacin susceptibilities of 5,667 Neisseria gonorrhoeae strains isolated in Hong Kong.
abstract: Of 5,667 strains of Neisseria gonorrhoeae isolated from the Government Social Hygiene (sexually transmitted disease) Clinics in Hong Kong from 1990 to 1992, there was a trend toward an increase in the percentage of strains resistant in vitro to 0.01 and 0.1 microgram of ofloxacin per ml, with 54.3 and 5.5% resistant strains, respectively, in January 1990, rising to 95.3 and 41.5%, respectively, in December 1992. The percentage of strains for which the MIC is > 1 microgram/ml remains stable, and no clinical failure has yet been seen. This trend of decreasing susceptibility warrants close monitoring when ofloxacin is used as first-line treatment for gonorrhea.
authors.affiliation: Institute of Pathology, Sai Ying Pun Polyclinic, Hong Kong.
authors.forename: K M
authors.initials: KM
authors.lastname: Kam
authors.forename: K K
authors.initials: KK
authors.lastname: Lo
authors.forename: C F
authors.initials: CF
authors.lastname: Lai
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: C B
authors.initials: CB
authors.lastname: Chan
mesh_terms: D006069:Gonorrhea / Q000382:microbiology; D006723:Hong Kong; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology*
chemical_list: D015242:Ofloxacin