The analysis of neural recognition molecules: benefits and vicissitudes of functional knock-outs using antibodies and gene ablation.
Altering or removing neural recognition molecules by blocking antibodies or genetic deletion has led to a flurry of predictions concerning their function. Each experimental approach has advantages and disadvantages that have to be considered when interpreting the resulting phenotypes.
Schachner
M
M
Department of Neurobiology, Swiss Federal Institute of Technology, Zürich.
D000818:Animals; D000906:Antibodies; D015816:Cell Adhesion Molecules, Neuronal / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D017353:Gene Deletion; D006801:Humans; D008959:Models, Neurological; D009185:Myelin Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000502:physiology*
D000906:Antibodies; D015816:Cell Adhesion Molecules, Neuronal; D009185:Myelin Proteins