title: Levo-praziquantel versus praziquantel in experimental and clinical treatment of schistosomiasis japonica.
abstract: Levo-praziquantel is the left isomer of racemic praziquantel. Animal experiments showed that it is an active component of schistosomicidal activity, while dextro-praziquantel is almost ineffective. Clinical trials in three endemic areas of Schistosomiasis japonica indicated that the therapeutic efficacy of levo-praziquantel is superior to racemic praziquantel. Pharmacokinetic and pharmacodynamic activities of the stereoselectivity of praziquantel isomers (enantiomers) are discussed.
authors.affiliation: Institute of Infections and Parasitic Diseases, Chong-qing University of Medical Sciences.
authors.forename: Y H
authors.initials: YH
authors.lastname: Liu
authors.forename: M X
authors.initials: MX
authors.lastname: Qian
authors.forename: X G
authors.initials: XG
authors.lastname: Wang
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Quan
authors.forename: S H
authors.initials: SH
authors.lastname: Yan
authors.forename: B Y
authors.initials: BY
authors.lastname: Chen
authors.forename: J S
authors.initials: JS
authors.lastname: Li
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Qiu
mesh_terms: D000818:Animals; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use* / Q000633:toxicity; D011817:Rabbits; D012554:Schistosomiasis japonica / Q000188:drug therapy*; D013237:Stereoisomerism
chemical_list: D011223:Praziquantel