[Early coverage of deep partial-thickness burn wound with porcine dermal collagen membrane. An experimental study].
Collagen was extracted by pepsin digestion from porcine skin and collagen membrane was prepared by salt precipitation. Collagen membrane as a wound dressing was evaluated in a deep partial-thickness burn wounds in a rat model. Burn wound, 4 x 4 cm, were inflicted by exposing skin to 75 degrees C for 15 seconds followed by de-epithelization. Wound healing was assessed by plenimetry of epithelization on day 10 postwounding. Open wounds exhibited a re-epithelialization of 24% of wound area. Collagen membrane dressing significantly improved the healing rate to approximately 70% of wound area.
Gao
Z R
ZR
Department of Burn Surgery, Affiliated Hospital of Qinghai Medical College.
D000818:Animals; D001684:Biological Dressings; D002056:Burns / Q000628:therapy*; D003094:Collagen; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing
D003094:Collagen