[Study on sodium norcantharidate albumin microspheres].
In this paper sodium norcantharidate (Na2NC) was chosen as model drug and sodium norcantharidate albumin microspheres (Na2NC AM) was prepared by an optimal procedure. The embedding nature, appearance, morphology, size and size distribution, release characteristics in vitro, freeze-drying, 60Co radiosterilization and stability of Na2NC AM were tested. The results showed that the mean size was 0.43 +/- 0.12 micron, embedding concentration was 20.34-26.75 micrograms/mg, embedding ratio was 21.9-26.4%, release characteristics in vitro was in accord with Higuchi equation. Freeze-drying and 60Co radiosterilization showed no influence on Na2NC AM. The stability of Na2NC AM was good after 3 months storage.
Cheng
Y H
YH
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Liao
G T
GT
Hou
S X
SX
Li
L
L
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D008863:Microspheres; D012710:Serum Albumin, Bovine
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004337:Drug Carriers; D012710:Serum Albumin, Bovine; C069741:norcantharidin