Investigation of cell envelope damage to Pseudomonas aeruginosa and Enterobacter cloacae by dibromopropamidine isethionate.
Electron micrographs of log-phase Pseudomonas aeruginosa and Enterobacter cloacae cultured for 4 h in the presence of subinhibitory concentrations of dibromopropamidine isethionate indicate that this antibacterial agent can cause marked damage to the cell envelope structures of both species. This result provides an explanation of how dibromopropamidine can enhance the uptake and thus the activity of a second antibacterial agent used in combination with it.
Richards
R M
RM
School of Pharmacy, Robert Gordon University, Schoolhill, Aberdeen, Scotland.
Xing
J Z
JZ
Gregory
D W
DW
Marshall
D
D
D000900:Anti-Bacterial Agents / Q000378:metabolism; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001550:Benzamidines / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001550:Benzamidines; C053597:dibrompropamidine