title: Platelet-rich plasma serotonin levels in tension-type headache and depression.
abstract: We measured platelet-rich plasma (PRP) serotonin in patients suffering from tension-type headache, before and after treatment with amitriptyline, comparing them with a healthy control group and patients with untreated depression. We evaluated the severity of headache and depression in each group. PRP serotonin levels were higher in patients with headache than in controls and depressed patients. We observed a fall of PRP serotonin in patients with tension-type headache to similar levels after treatment as the depressed group. This fall was correlated with the improvement of headache but not with depression scales. Our data suggest that the rise of platelet serotonin levels in tension-type headache is related to pain and not depression.
authors.affiliation: Department of Neurology, Hospital General de Galicia, Clínico Universitario, Santiago de Compostela, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Leira
authors.forename: J
authors.initials: J
authors.lastname: Castillo
authors.forename: F
authors.initials: F
authors.lastname: Martinez
authors.forename: J M
authors.initials: JM
authors.lastname: Prieto
authors.forename: M
authors.initials: M
authors.lastname: Noya
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000494:pharmacology / Q000627:therapeutic use; D001792:Blood Platelets / Q000737:chemistry* / Q000187:drug effects; D003863:Depression / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006261:Headache / Q000097:blood* / Q000145:classification / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*
chemical_list: D000639:Amitriptyline; D012701:Serotonin