Morphologic effects of artemether on Plasmodium falciparum in Aotus trivirgatus.
The effects of artemether on the morphology of Plasmodium falciparum were studied in an owl monkey (Aotus trivirgatus) when parasitemia reached 33% and the animal became severely ill. The earliest and the most distinctive ultrastructural changes following the administration of artemether were marked swelling of the mitochondria in the parasites, followed by the appearance of electron-dense chromatin materials in the nuclei and clumping of ribosomes. The initial change was observed within 2 hr of administration of the drug. These findings correlate well with the rapid and effective action of artemether, which has been demonstrated in human clinical trials.
Kawai
S
S
Department of Parasitology, Gunma University School of Medicine, Maebashi, Japan.
Kano
S
S
Suzuki
M
M
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D001029:Aotus trivirgatus; D000077549:Artemether; D037621:Artemisinins; D002467:Cell Nucleus / Q000187:drug effects; D002843:Chromatin / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000648:ultrastructure; D012717:Sesquiterpenes / Q000494:pharmacology* / Q000627:therapeutic use
D000962:Antimalarials; D037621:Artemisinins; D002843:Chromatin; D012717:Sesquiterpenes; D000077549:Artemether