Needle aspiration cytology, immunocytochemistry, and electron microscopic study in a case of carcinoid of the male breast.
The diagnosis of a primary carcinoid of breast in a 68-yr-old male was initially made from a sample of needle aspirate. The cytodiagnosis was supported by histochemical and immunocytochemical studies which showed positivity for argyrophilic granules by Grimelius stain and positive staining for chromogranin. A subsequent cell block of the aspirate and biopsy of the tumour confirmed the cytodiagnosis. Electron microscopic study of the material further demonstrated the presence of neurosecretory granules in the malignant cells. Mastectomy with axillary node dissection was performed and showed no residual or metastatic tumour. No primary tumour was found elsewhere. This case illustrates the importance of needle aspiration cytology in the diagnosis of carcinoid tumour which is very rare in the male breast.
Gupta
R K
RK
Department of Pathology, Wellington Hospital and School of Medicine, New Zealand.
Holloway
L J
LJ
Wakefield
S J
SJ
D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D002276:Carcinoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron