Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models.
Tolmetin sodium's efficacy in preventing primary adhesions was evaluated in two adhesion models each in two species: (1) rabbit uterine horn, (2) rat uterine horn, (3) rabbit peritoneal side wall, and (4) rat peritoneal side wall. In each model a single instillation of tolmetin sodium solution into the peritoneal cavity at the time of surgery effectively reduced adhesion formation. This efficacy extended over a wide range of concentrations, volumes, and total dosages, and was similar in rabbits and rats. An aqueous solution of 1 mg/ml tolmetin sodium in 5-15 ml in rabbits and in 3 ml in rats was consistently efficacious in reducing postoperative adhesion formation.
LeGrand
E K
EK
Pharmaceutical Research and Development, Ethicon, Inc., Somerville, New Jersey 08876-0151.
Rodgers
K E
KE
Girgis
W
W
Struck
K
K
Campeau
J D
JD
diZerega
G S
GS
Kiorpes
T C
TC
D000818:Animals; D005260:Female; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control*; D014046:Tolmetin / Q000008:administration & dosage / Q000627:therapeutic use*; D014591:Uterine Diseases / Q000517:prevention & control*
D014046:Tolmetin