Bone remodelling in the presence of chondrosarcoma: histomorphometry.
Accurate knowledge of tissue changes near bone tumors can contribute to a better understanding of tumor behavior. We have used tumor ultrastructure and quantitative bone histomorphometry to evaluate local bone/tumor features associated with a low grade chondrosarcoma in a 39-year-old male. Three noninvolved sites and two sites near the tumor in the proximal femur were studied with bone morphometry. Bone near the tumor showed increased percent osteoid surface, percent osteoid volume and fraction of osteoid surface lined by osteoblasts compared to distant noninvolved sites. Both the number of osteoblasts and mean individual osteoblast size were significantly increased compared to noninvolved sites. Osteoclast number and percent osteoclast surface were also increased near the tumor. Ultrastructural studies of tumor tissue revealed two types of tissue: synthetic mesenchymal cells and cartilage tissue. Results indicate increased bone formation and resorption near the tumor. These local bone changes may possibly reflect responses to local tumor factors and depend on the extent of the tumor.
Gruber
H E
HE
Medical Genetics-Birth Defects Center, Cedars-Sinai Medical Center, Los Angeles, Calif.
Marshall
G J
GJ
Kirchen
M E
ME
Menendez
L R
LR
Schwinn
C P
CP
D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology* / Q000503:physiopathology* / Q000648:ultrastructure; D016723:Bone Remodeling; D002813:Chondrosarcoma / Q000473:pathology* / Q000503:physiopathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron