Two new cytotoxic chalcones from Calythropsis aurea.
The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new chalcones, calythropsin [1] and dihydrocalythropsin [2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.
Beutler
J A
JA
Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, Maryland 21702-1201.
Cardellina
J H
JH
Gray
G N
GN
Prather
T R
TR
Shoemaker
R H
RH
Boyd
M R
MR
Lin
C M
CM
Hamel
E
E
Cragg
G M
GM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D008938:Mitosis / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D011427:Propiophenones / Q000302:isolation & purification* / Q000494:pharmacology; D014404:Tubulin / Q000378:metabolism; D014904:Western Australia
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D011427:Propiophenones; D014404:Tubulin; C085138:dihydrocalythropsin; C085139:calythropsin; D002599:Chalcone