Thienyl-GABA derivatives as specific baclofen agonists in the rat and cat spinal cord in vivo.
The depression of the amplitude of extracellularly recorded monosynaptic excitatory field potentials in the lumbar spinal cord of pentobarbitone anaesthetised rats and cats by three thienyl derivatives of GABA: 4-amino-3-(2-thienyl)-butanoic acid; 4-amino-3-(2-thienyl-5-methyl)-butanoic acid and 4-amino-3-(2-thienyl-5-chloro)-butanoic acid was reversibly blocked by the (-)-baclofen antagonist 3-aminopropyl-diethoxymethyl-phosphinic acid (CGP 35348). These compounds, of which the most potent, the 5-chloro derivative, was weaker than (-)-baclofen, thus activate baclofen receptors in the cat and rat spinal cord.
Lacey
G
G
Division of Neuroscience, John Curtin School of Medical Research, Canberra, ACT Australia.
Berthelot
P
P
Vaccher
C
C
Flouquet
N
N
Vaccher
M P
MP
Debaert
M
M
Curtis
D R
DR
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002415:Cats; D004586:Electrophoresis; D005071:Evoked Potentials / Q000187:drug effects; D058787:GABA-A Receptor Antagonists; D009943:Organophosphorus Compounds / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000187:drug effects; D018080:Receptors, GABA-B / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D058787:GABA-A Receptor Antagonists; D009943:Organophosphorus Compounds; D018079:Receptors, GABA; D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid; C066430:CGP 35348; D001418:Baclofen