title: Delayed brain hemorrhage associated with prophylactic whole brain irradiation for pediatric malignant brain tumor: a case report.
abstract: Intraparenchymal hemorrhage in the left frontal lobe suddenly occurred in a 7-year-old girl who had undergone partial removal of an undifferentiated brain stem glioma and received craniospinal (30 Gy) and posterior fossa booster (20 Gy) irradiation at the age of 20 months. The brain hemorrhage was thought to be delayed irradiation effect. Follow-up neuro-imaging at age 9 years showed two more small occult chronic and subacute hemorrhages in the brain. The possibility of repeated hemorrhage as a delayed reaction to brain irradiation is emphasized.
authors.affiliation: Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.forename: N
authors.initials: N
authors.lastname: Ono
authors.forename: A
authors.initials: A
authors.lastname: Zama
authors.forename: H
authors.initials: H
authors.lastname: Fujimaki
authors.forename: C
authors.initials: C
authors.lastname: Ohye
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D001933:Brain Stem / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery; D002536:Cerebral Arteries / Q000473:pathology / Q000528:radiation effects; D002543:Cerebral Hemorrhage / Q000473:pathology* / Q000601:surgery; D002675:Child, Preschool; D016371:Cranial Irradiation; D005260:Female; D005910:Glioma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006406:Hematoma / Q000473:pathology / Q000601:surgery; D006801:Humans; D011183:Postoperative Complications / Q000473:pathology / Q000601:surgery; D011832:Radiation Injuries / Q000473:pathology* / Q000601:surgery; D012086:Reoperation; D014057:Tomography, X-Ray Computed