Behaviour of white blood cells and the complement system.
Seven different types of dialysers were investigated in five dialysis centres in four countries with respect to behaviour of white blood cells and the complement system. The results of this controlled crossover study demonstrated significant differences in the dialysers. Those containing cuprammonium cellulose (G10-3N and G120 M) showed the greatest changes in white blood cell count, including monocytes and neutrophils, as well as the greatest complement activation. With regard to lymphocytes the subpopulation of low-mobility cells, which were predominantly the B-cells, showed the greatest mobility with dialysers containing cuprammonium cellulose. The PAN copolymer- and PMMA-containing dialysers Filtral and T 150 clearly caused the least changes in white blood cells and complement factors. Dialysers containing cellulose acetate and polysulphone membranes (Duo-Flux Artificial Kidney, CD 4000, and F 60) produced only a moderate decrease of WBC, monocyte, neutrophil, and lymphocyte counts, and this result corresponded to a relatively small change in complement factors.
Falkenhagen
D
D
Department of Internal Medicine, University of Rostock, Germany.
Brown
G S
GS
Thomaneck
U
U
Levin
N W
NW
Ivanovich
P
P
Bergstrom
J
J
Kishimoto
T
T
Klinkmann
H
H
D000180:Acrylic Resins / Q000627:therapeutic use; D000181:Acrylonitrile / Q000031:analogs & derivatives / Q000627:therapeutic use; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D003167:Complement Activation; D015926:Complement C3a / Q000031:analogs & derivatives / Q000032:analysis; D003165:Complement System Proteins / Q000502:physiology*; D004586:Electrophoresis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008768:Methylmethacrylates / Q000627:therapeutic use; D009504:Neutrophils / Q000473:pathology; D006435:Renal Dialysis / Q000295:instrumentation; D014680:Veins
D000180:Acrylic Resins; D001672:Biocompatible Materials; D008768:Methylmethacrylates; C044541:complement C3a, des-Arg-(77)-; C016892:AN-69; D015926:Complement C3a; D002482:Cellulose; D003165:Complement System Proteins; C009865:cuprammonium cellulose; D000181:Acrylonitrile