[Recent progress in experimental pituitary tumors in various animals].
This article briefly describes the recent progress and opinion on experimental pituitary tumors in various animals. 1) A high incidence of spontaneous pituitary tumor is known in Sprague-Dawley and Wistar rats. 2) Recent studies suggest that the pituitaries of estrogen-treated animals are not tumoral and only hyperplastic. 3) Salmon calcitonin injection for 6 months caused a higher incidence of pituitary hyperplasia or non-functioning adenoma. 4) Mice transgenic by hGRF shows GH-producing hyperplasia or adenoma in the pituitary. 5) Introduction of choleratoxin transgene into mice caused gigantism. 6) Transgenic mice, that develop ACTH-producing pituitary tumor, were generated by PyLT. 7) Mice transgenic for vasopressin-SV 40 hybrid oncogene develop tumors of the endocrine pancreas and the pituitary (as a model of MEN type II).
Ishii
J
J
Fourth Department of Internal Medicine, Saitama Medical School.
Kawakami
Y
Y
D000236:Adenoma / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010902:Pituitary Gland / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured