title: [The clinical evaluation of UF-021, a new prostaglandin related compound, in low tension glaucoma patients].
abstract: We administered UF-021 isopropyl unoprostone (Rescula) ophthalmic solution, a new prostaglandin-related compound developed as an anti-glaucoma agent, to 13 low tension glaucoma patients for 24 weeks, and clinically evaluated the effect of the intraocular pressure (IOP) reduction, visual field change, and side effects of the agent. Intraocular pressure was reduced in 11 out of 12 patients who were studied for statistical analysis. In these 12 patients, significant IOP reduction was recognized in the mean IOP for 24 weeks after the administration of UF-021. No side effects were detected in any of the 13 patients. From these results, UF-021 could be used as a new anti-glaucoma agent for low tension glaucoma, and also safer than many other anti-glaucoma agents.
authors.affiliation: Department of Ophthalmology, Yamanashi Medical College, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Fujimori
authors.forename: S
authors.initials: S
authors.lastname: Yamabayashi
authors.forename: M
authors.initials: M
authors.lastname: Hosoda
authors.forename: O
authors.initials: O
authors.lastname: Hosaka
authors.forename: F
authors.initials: F
authors.lastname: Makino
authors.forename: T
authors.initials: T
authors.lastname: Henmi
authors.forename: S
authors.initials: S
authors.lastname: Tsukahara
authors.forename: R
authors.initials: R
authors.lastname: Ueno
mesh_terms: D000328:Adult; D000368:Aged; D015237:Dinoprost / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions
chemical_list: D009883:Ophthalmic Solutions; C072630:isopropyl unoprostone; D015237:Dinoprost