Spectral localization of arbitrarily shaped regions of interest (SLASH) using single voxel signals.
A method for obtaining localized spectra from arbitrarily shaped regions of interest is described. When a sample consists of homogeneous compartments or domains, spectra localized in each compartment can be obtained from signals of single voxels with regular shapes by solving a set of simultaneous linear equations. Experimental demonstrations on a phantom and on human brain in vivo for a two compartment, two voxel case are presented. The issue of signal-to-noise ratio is also discussed.
Wang
Z
Z
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
Reddy
R
R
Haselgrove
J C
JC
Chen
C Y
CY
Goelman
G
G
Zimmerman
R A
RA
Leigh
J S
JS
D001921:Brain / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008961:Models, Structural