X-linked agammaglobulinemia--gene cloning and future prospects.
The btk gene has recently been identified as the causative gene in X-linked agammaglobulinemia (XLA). This has opened up many new possibilities for the treatment of this B-cell immunodeficiency. Christine Kinnon and colleagues review the high degree of sequence of homology of btk to the non-receptor tyrosine kinases and speculate on putative roles for this gene in B-cell development.
Kinnon
C
C
Molecular Immunology Unit, University of London, UK.
Hinshelwood
S
S
Levinsky
R J
RJ
Lovering
R C
RC
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000361:Agammaglobulinemia / Q000235:genetics*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D005544:Forecasting; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology; D014960:X Chromosome
D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human