Murine chromosomal location of four class III POU transcription factors.
A family of mouse genes encoding class III POU transcription factors consists of four members: Oct-6, Brn-2, Brn-1, and Brn-4. In accordance with mouse nomenclature, these loci have been designated Otf-6, Otf-7, Otf-8, and Otf-9, respectively. While the four genes share a highly conserved class III POU domain, the remaining regions are considerably diverged from each other. The POU domains of these transcription factors recognize the octamer-motif sequence and possess a similar DNA-binding specificity. Chromosomal mapping has demonstrated that the four genes are unlinked: Otf-6 is located on the distal region of chromosome 4, Otf-7 on the proximal region of chromosome 4, Otf-8 on chromosome 1, and Otf-9 on the X chromosome.
Avraham
K B
KB
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research and Development Center, Maryland 21702.
Cho
B C
BC
Gilbert
D
D
Fujii
H
H
Okamoto
K
K
Shimazaki
T
T
Ito
T
T
Shoji
H
H
Wakamatsu
Y
Y
Kondoh
H
H
D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D050809:POU Domain Factors; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D050809:POU Domain Factors; D014157:Transcription Factors