title: An assessment of the success of meperidine and promethazine sedation in medically compromised children.
abstract: A retrospective study evaluated the success of orally administered meperidine (1.0 mg/lb) and promethazine (0.5 mg/lb) combined with N20:02, and determined predictors of success in a medically, physically and/or mentally compromised population. Behavior of 143 uncooperative patients (mean age 6.4 years) was evaluated during 282 sedations. A simplified Success Index rated outcome: 1-failure, 2-moderately successful; 3-highly successful. Variables were examined for effect on outcome of sedation: physical and/or neurologic component of medical diagnosis; previous hospital experience; medication category. Children taking medications with CNS actions were significantly less likely to have either moderately successful (p = .008) or highly successful appointments (p = .002). Children with a neurologic component to their medical diagnosis were significantly less likely to have a highly successful appointment (p = .001). Oral sedation was effective for this population (77 percent were successful) and certain characteristics of the patient's condition can predict success.
authors.affiliation: Department of Pediatric Dentistry, Baylor College of Dentistry.
authors.forename: K L
authors.initials: KL
authors.lastname: Haney
authors.forename: A G
authors.initials: AG
authors.lastname: McWhorter
authors.forename: N S
authors.initials: NS
authors.lastname: Seale
mesh_terms: D000293:Adolescent; D000766:Anesthesia, Dental / Q000379:methods*; D002491:Central Nervous System Agents / Q000494:pharmacology; D016009:Chi-Square Distribution; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D003730:Dental Care for Persons with Disabilities; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000008:administration & dosage; D009609:Nitrous Oxide / Q000008:administration & dosage; D017063:Outcome Assessment, Health Care; D010349:Patient Compliance; D011398:Promethazine / Q000008:administration & dosage; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D002491:Central Nervous System Agents; D004338:Drug Combinations; D008614:Meperidine; D011398:Promethazine; D009609:Nitrous Oxide