title: Epidermal growth factor in the topical treatment of traumatic corneal ulcers.
abstract: The tolerability and efficacy of epidermal growth factor (EGF) in the topical treatment of traumatic corneal ulcers have been evaluated in a double-blind, placebo-controlled, randomized study in two groups of patients. The time required for complete reepithelialization of the cornea was recorded, and the data obtained were analyzed statistically. In the EGF group the reepithelialization was significantly faster than in the control group. Tolerability of EGF was always excellent. These results indicate that EGF is safe and effective in reducing the healing time in the management of superficial corneal lesions.
authors.affiliation: Divisione Oculistica, Ospedale Generale, Imola, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Scardovi
authors.forename: G P
authors.initials: GP
authors.lastname: De Felice
authors.forename: A
authors.initials: A
authors.lastname: Gazzaniga
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D003315:Cornea / Q000187:drug effects; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000209:etiology; D004311:Double-Blind Method; D004815:Epidermal Growth Factor / Q000008:administration & dosage* / Q000627:therapeutic use; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D014945:Wound Healing / Q000187:drug effects
chemical_list: D009883:Ophthalmic Solutions; D004815:Epidermal Growth Factor