Mechanisms of illegitimate recombination.
Illegitimate recombination, which is one of the major causes of genome rearrangements, can occur in a number of ways. These might involve enzymes which cut and join DNA or enzymes which replicate DNA, as illustrated by two examples: (i) formation of deletions at the replication origin (ori) of an Escherichia coli bacteriophage, M13; and (ii) excision of E. coli transposon Tn10. It is proposed that a common theme to various ways by which illegitimate recombination can occur might be the capacity to create ends in the DNA molecule and to make the ends meet.
Ehrlich
S D
SD
Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas, France.
Bierne
H
H
d'Alençon
E
E
Vilette
D
D
Petranovic
M
M
Noirot
P
P
Michel
B
B
D017104:Bacteriophage M13 / Q000235:genetics; D004251:DNA Transposable Elements; D004926:Escherichia coli / Q000235:genetics; D011995:Recombination, Genetic
D004251:DNA Transposable Elements