Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol.
A study of 18 different commercially available continuous-flow, jet nebulizers was performed with a standard liposomal formulation of beclomethasone dipropionate (Bec-DP) prepared with dilauroyl phosphatidylcholine (Bec-DLPC). The analysis compared the total Bec-DP output from aqueous suspensions of Bec-DLPC containing an initial starting reservoir concentration of 0.5 mg/ml. Aerosols from each nebulizer tested were characterized by the mass median aerodynamic diameter, geometric standard deviation, drug output, and the predicted percentage regional deposition of inhaled Bec-DLPC liposomes within the human respiratory tract. These data can provide a basis for the selection of commercially available jet nebulizers for use with glucocorticoid liposome aerosols for treatment of asthma and other inflammatory lung diseases.
Waldrep
J C
JC
Center for Biotechnology, Baylor College of Medicine, The Woodlands, Tex. 77381.
Keyhani
K
K
Black
M
M
Knight
V
V
D000336:Aerosols; D001507:Beclomethasone / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers; D004867:Equipment Design; D006801:Humans; D008081:Liposomes; D008168:Lung / Q000378:metabolism; D008954:Models, Biological; D009058:Mouth Breathing; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D012123:Pulmonary Ventilation; D012115:Residual Volume; D013499:Surface Properties; D013990:Tidal Volume
D000336:Aerosols; D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; C015153:1,2-dilauroylphosphatidylcholine; D001507:Beclomethasone