title: Pulsatile low-flow perfusion for enhanced cerebral protection.
abstract: We examined the oxygen tension, carbon dioxide tension, and pH in canine brains under profound hypothermia to evaluate the effects of perfusion (circulatory arrest for 1 hour; 25 and 50 mL.kg-1 x min-1 for 2 hours) with and without pulsatile assistance. The effects of pulsatile flow on cerebral blood flow and metabolism were also evaluated in dogs supported by low-flow perfusion (25 mL.kg-1 x min-1) for 2 hours. Profound hypoxia occurred in the brain after 20 to 60 minutes of circulatory arrest. Brain tissue acidosis with hypercapnia was moderated by perfusion at a rate of flow of 50 mL.kg-1 x min-1. Pulsatile low-flow perfusion (25 mL.kg-1 x min-1) moderated cerebral hypercapnia and made the cerebral metabolism aerobic without affecting the total cerebral blood flow and consumption of oxygen.
authors.affiliation: Second Department of Surgery, Yamagata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Washio
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004285:Dogs; D006324:Heart Arrest, Induced; D007036:Hypothermia, Induced; D002534:Hypoxia, Brain / Q000503:physiopathology / Q000517:prevention & control*; D010100:Oxygen / Q000097:blood; D011673:Pulsatile Flow / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen