title: Can ECT-induced cognitive effects be altered pharmacologically?
abstract: 1. A systematic review of the literature revealed twelve clinical trials that evaluated nine different drugs, and used three different conceptual models to prevent, restore or treat ECT-induced cognitive deficits. 2. This review indicated inconclusive results regarding clinical utility of any of the drugs. 3. Major factors discussed include the complexities involved in the evaluation of ECT-induced cognitive deficits, and the techniques of evaluating changes in cognitive functions. 4. Our conclusion is that future research should emphasize understanding the neural mechanisms related to ECT-induced cognitive deficits. We suggest several areas for future exploration.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle.
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: M H
authors.initials: MH
authors.lastname: Mirolo
authors.forename: H A
authors.initials: HA
authors.lastname: Mirolo
authors.forename: S
authors.initials: S
authors.lastname: Miller
mesh_terms: D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D006801:Humans