title: Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin.
abstract: Invasive adenovirus infection is recognized as an unusual cause of serious end-organ sequelae following BMT. Because symptomatic therapy may be inadequate for more serious infections, the use of investigational agents is justified. We describe a case of severe, progressive nephritis secondary to adenovirus serotype 11 following BMT. Treatment with i.v. ribavirin led to prompt clinical improvement and resolution of adenovirus excretion.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA.
authors.forename: W C
authors.initials: WC
authors.lastname: Liles
authors.forename: H
authors.initials: H
authors.lastname: Cushing
authors.forename: S
authors.initials: S
authors.lastname: Holt
authors.forename: C
authors.initials: C
authors.lastname: Bryan
authors.forename: R C
authors.initials: RC
authors.lastname: Hackman
mesh_terms: D000257:Adenoviridae Infections / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D016026:Bone Marrow Transplantation; D003556:Cystitis / Q000188:drug therapy / Q000382:microbiology; D006086:Graft vs Host Disease / Q000150:complications; D006470:Hemorrhage / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000628:therapy; D008297:Male; D009393:Nephritis / Q000188:drug therapy / Q000382:microbiology*; D012254:Ribavirin / Q000627:therapeutic use*; D016879:Salvage Therapy
chemical_list: D012254:Ribavirin