title: Aberrant CD8 antigen expression in a patient with B chronic lymphocytic leukaemia showing unusual disease progression.
abstract: Co-expression of T cell antigens in B-CLL has been well recognized. The commonest T cell antigen known to be expressed in B-CLL is CD5, and recent reports suggest that CD5 expression is associated with good prognosis. Expression of CD8 antigen, however, is much less common with uncertain prognostic significance. We report a case of B-CLL with aberrant CD8 expression, who had unusual disease progression with a fatal outcome.
authors.affiliation: Department of Hameatology, Leicester Royal Infirmary.
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
authors.forename: M
authors.initials: M
authors.lastname: Sivakumaran
authors.forename: J K
authors.initials: JK
authors.lastname: Wood
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D016827:CD8 Antigens / Q000097:blood*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008297:Male; D011379:Prognosis
chemical_list: D000951:Antigens, Neoplasm; D016827:CD8 Antigens