title: Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X.
abstract: We report here the isolation and characterization of a novel human elongation factor-1 beta (EF-1 beta) gene by cDNA selection from YAC mapping on chromosome 5q12-q14. This gene is specifically transcribed in fetal brain and in skeletal muscle and is characterized by a complete sequence homology with previously described EF-1 beta cDNAs. We also assigned the loci for three other EF-1 beta isoforms, to human chromosomes 2, 15 and X. The multiple chromosomal assignments of EF-1 beta loci demonstrates the genetic heterogeneity of human EF-1 beta peptides.
authors.affiliation: Institute for Molecular Genetics and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: A
authors.initials: A
authors.lastname: Pizzuti
authors.forename: M
authors.initials: M
authors.lastname: Gennarelli
authors.forename: G
authors.initials: G
authors.lastname: Novelli
authors.forename: A
authors.initials: A
authors.lastname: Colosimo
authors.forename: S
authors.initials: S
authors.lastname: Lo Cicero
authors.forename: C T
authors.initials: CT
authors.lastname: Caskey
authors.forename: B
authors.initials: B
authors.lastname: Dallapiccola
mesh_terms: D001483:Base Sequence; D001921:Brain / Q000196:embryology; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002877:Chromosomes, Human; D002884:Chromosomes, Human, Pair 15; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009132:Muscles / Q000196:embryology; D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D014018:Tissue Distribution; D014158:Transcription, Genetic; D014960:X Chromosome
chemical_list: D018076:DNA, Complementary; D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors