title: Mechanically induced calcium signal in mammary epithelial cells.
abstract: In mouse mammary epithelial cells, mechanical stimulation of a cell induced an increase of intracellular Ca2+ concentration (Ca2+i), which spread from the stimulated cell to the surrounding cells with a conduction velocity of about 10 microns/s. The Ca2+i signal was transmitted between isolated cells or separated colonies, where there was no physical contact between them. The flow of medium changed the spreading pattern of Ca2+ wave. The Ca2+ wave was induced even in Ca(2+)-free solution. These findings suggested that a certain factor was released from stimulated cell to extracellular medium and it induced the Ca2+i increase from intracellular store in the surrounding cells.
authors.affiliation: Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Furuya
authors.forename: K
authors.initials: K
authors.lastname: Enomoto
authors.forename: T
authors.initials: T
authors.lastname: Maeno
authors.forename: S
authors.initials: S
authors.lastname: Yamagishi
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D004847:Epithelial Cells; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology / Q000502:physiology*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010812:Physical Stimulation; D015398:Signal Transduction / Q000502:physiology*; D014407:Tumor Cells, Cultured
chemical_list: D002118:Calcium