title: [Hereditary thrombophilia as a cause of recurrent transplant thromboses].
abstract: We report a case of hereditary protein S and protein C deficiency which are a rare defects of the anti-coagulation-system. Protein S is a vitamin K dependent glycoprotein that functions as a cofactor to activated Protein C in the inactivation of coagulation factors V and VIIIa. A deficiency of these proteins caused by a genetic defect increase the risk of recurrent thrombosis at a younger age. Acquired decreases in protein S and C concentration have been reported in connection with age, sex, pregnancy and with oral anticonception. The higher risk for thrombotic diseases of patients with thrombophilia requires a sufficient treatment and prophylaxis, e.g. with fresh frozen plasma or a protein C concentrate.
authors.affiliation: Allgemeinchirurgische Klinik und Poliklinik, Universität Tübingen.
authors.forename: B H
authors.initials: BH
authors.lastname: Koester
authors.forename: G B
authors.initials: GB
authors.lastname: Köveker
authors.forename: B
authors.initials: B
authors.lastname: Pötsch
authors.forename: H D
authors.initials: HD
authors.lastname: Becker
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000235:genetics; D007676:Kidney Failure, Chronic / Q000097:blood / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology; D020151:Protein C Deficiency; D018455:Protein S Deficiency; D012078:Renal Artery Obstruction / Q000097:blood / Q000235:genetics*; D013927:Thrombosis / Q000097:blood / Q000235:genetics*
vernacular_title: Hereditäre Thrombophilie als Ursache rezidivierender Transplantatthrombosen.