Cytomegalovirus antigenemia: clinical correlations in transplant recipients and in persons with AIDS.
We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.
Mazzulli
T
T
Infectious Disease Unit, Massachusetts General Hospital, Boston.
Rubin
R H
RH
Ferraro
M J
MJ
D'Aquila
R T
RT
Doveikis
S A
SA
Smith
B R
BR
The
T H
TH
Hirsch
M S
MS
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000956:Antigens, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000382:microbiology*; D006801:Humans; D009504:Neutrophils / Q000382:microbiology; D016377:Organ Transplantation / Q000009:adverse effects*
D000956:Antigens, Viral