title: Corneoscleral ulceration and corneal perforation after pterygium excision and topical mitomycin C therapy.
abstract: A 78-year-old woman complained of ocular pain in the right eye. Thirty-three months before, the patient had a pterygium excised and mitomycin C, 0.04%, was instilled 3 times a day postoperatively for 10 days in the right eye. The same surgery was performed and the same drug was used for a course of 5 days in the left eye. Corneoscleral ulceration and corneal performation occurred in the right eye. The lesions were successfully treated with a lamellar patch graft with reserved corneosclera. We believe that it may not be safe to instill 0.04% mitomycin C 3 times a day postoperatively for 10 days.
authors.affiliation: Department of Ophthalmology, Shimane Medical University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fujitani
authors.forename: S
authors.initials: S
authors.lastname: Hayasaka
authors.forename: Y
authors.initials: Y
authors.lastname: Shibuya
authors.forename: S
authors.initials: S
authors.lastname: Noda
mesh_terms: D000287:Administration, Topical; D000368:Aged; D003320:Corneal Ulcer / Q000139:chemically induced* / Q000601:surgery; D005260:Female; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects*; D009883:Ophthalmic Solutions; D011183:Postoperative Complications; D011625:Pterygium / Q000188:drug therapy / Q000601:surgery*; D015422:Scleral Diseases / Q000139:chemically induced* / Q000601:surgery; D014456:Ulcer / Q000139:chemically induced / Q000601:surgery
chemical_list: D009883:Ophthalmic Solutions; D016685:Mitomycin