title: Depletion of intramuscularly and subcutaneously injected procaine penicillin G from tissues and plasma of yearling beef steers.
abstract: Withdrawal periods required when doses of 24,000 IU and 66,000 IU of procaine penicillin G/kg body weight were administered to yearling beef steers by intramuscular injection daily for five consecutive days were investigated. These dosages are in excess of product label recommendations, but are in the range of procaine penicillin G dosages that have been administered for the treatment of some feedlot bacterial diseases. The approved dose in Canada is 7,500 IU/kg body weight intramuscularly, once daily, with a withdrawal period of five days. Based on the tissue residue data from this study, the appropriate withdrawal period is ten days for the 24,000 IU/kg body weight dose and 21 days for the 66,000 IU/kg body weight dose when administered intramuscularly to yearling beef steers. In a related study, 18 yearling beef steers received 66,000 IU of procaine penicillin G/kg body weight administered by subcutaneous injection, an extra-label treatment in terms of both dose and route of administration, typical of current practice in some circumstances. Deposits of the drug were visible at subcutaneous injection sites up to ten days after injection, with more inflammation and hemorrhage observed than for intramuscular injections of the same dose. These results suggest that procaine penicillin G should not be administered subcutaneously at high doses; and therefore a withdrawal period was not established for subcutaneous injection.
authors.affiliation: Health of Animals Laboratory, Agriculture Canada, Saskatoon, Saskatchewan.
authors.forename: G O
authors.initials: GO
authors.lastname: Korsrud
authors.forename: J O
authors.initials: JO
authors.lastname: Boison
authors.forename: M G
authors.initials: MG
authors.lastname: Papich
authors.forename: W D
authors.initials: WD
authors.lastname: Yates
authors.forename: J D
authors.initials: JD
authors.lastname: MacNeil
authors.forename: E D
authors.initials: ED
authors.lastname: Janzen
authors.forename: R D
authors.initials: RD
authors.lastname: Cohen
authors.forename: D A
authors.initials: DA
authors.lastname: Landry
authors.forename: G
authors.initials: G
authors.lastname: Lambert
authors.forename: M S
authors.initials: MS
authors.lastname: Yong
mesh_terms: D000818:Animals; D001835:Body Weight; D002417:Cattle / Q000378:metabolism*; D004350:Drug Residues / Q000032:analysis / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000737:chemistry / Q000378:metabolism; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D010402:Penicillin G Procaine