Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumours.
The effect of nicotinamide and/or carbogen breathing on the response of EMT6 and HRT18 tumours, irradiated in vivo, was evaluated using an in vitro colony assay. In the single dose schedules, the most efficient treatment was carbogen plus nicotinamide compared to air breathing mice. In a fractionated regime carbogen plus nicotinamide increased also response to radiation.
Simon
J M
JM
Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.
Lartigau
E
E
Guichard
M
M
D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology*; D002470:Cell Survival / Q000528:radiation effects; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D009536:Niacinamide / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology*; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; D009536:Niacinamide; C011700:carbogen; D010100:Oxygen