title: [The adaptive response of B cells to the action of cytotoxic preparations in culture. III. The possible mechanism of the action of adriamycin on immunoglobin synthesis by the cells of murine myeloma].
abstract: A dose-dependent stimulation of immunoglobulin synthesis by Spebr-5 cells in the presence of adriamycin is shown. This effect is significantly blocked in the presence of iron-chelating agent 2,2-bipyridine. Moreover, low doses of H2O2 and heat shock also caused enhancement of immunoglobulin synthesis. These data suggest the involvement of free radical processes in the adriamycin induced stimulation of immunoglobulin synthesis.
authors.forename: M B
authors.initials: MB
authors.lastname: Meliksetian
authors.forename: T K
authors.initials: TK
authors.lastname: Davtian
authors.forename: I V
authors.initials: IV
authors.lastname: Ivanova
authors.forename: Iu T
authors.initials: IuT
authors.lastname: Aleksanian
authors.forename: T N
authors.initials: TN
authors.lastname: Ignatova
mesh_terms: D015082:2,2'-Dipyridyl / Q000494:pharmacology; D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D002460:Cell Line; D003545:Cysteine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D004347:Drug Interactions; D004351:Drug Resistance; D004996:Ethidium / Q000037:antagonists & inhibitors; D005978:Glutathione / Q000494:pharmacology; D007136:Immunoglobulins / Q000096:biosynthesis / Q000187:drug effects*; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology / Q000378:metabolism*; D013268:Stimulation, Chemical; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D007136:Immunoglobulins; D015082:2,2'-Dipyridyl; D004317:Doxorubicin; D004996:Ethidium; D005978:Glutathione; D003545:Cysteine
vernacular_title: Adaptivnyĭ otvet B-kletok na deĭstvie tsitotoksicheskikh preparatov v kul'ture III. Vozmozhnyĭ mekhanizm vliianiia adriamitsina na sintez immunoglobulinov kletkami myshinoĭ mielomy.