title: [Ischemic encephalopathy in primary antiphospholipid syndrome].
abstract: A 39-year-old man with livedo reticularis, optic neuropathy and acute ischemic encephalopathy (Sneddon's syndrome) had antiphospholipid antibodies. This primary antiphospholipid antibody syndrome was unsuccessfully treated by anticoagulation, corticosteroids and plasma exchanges. Despite a frank reduction of the circulating antibody titers after plasma exchanges, no improvement of the neurological symptoms was observed. Death was related to a systemic complication when the antibody titer was at its lowest level. This case provides further evidence that effective treatment for stroke associated with antiphospholipid antibodies is still wanting.
authors.affiliation: Service de Neurologie, Hôpital Pasteur, Nice.
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: C
authors.initials: C
authors.lastname: Lebrun
authors.forename: M H
authors.initials: MH
authors.lastname: Mahagne
authors.forename: C
authors.initials: C
authors.lastname: Desnuelles
authors.forename: M
authors.initials: M
authors.lastname: Chatel
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001284:Atrophy; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002540:Cerebral Cortex / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009902:Optic Neuritis / Q000209:etiology; D010951:Plasma Exchange; D017445:Skin Diseases, Vascular / Q000209:etiology; D013577:Syndrome; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D017152:Antibodies, Antiphospholipid
vernacular_title: Encéphalopathie ischémique au cours d'un syndrome primaire des anticorps antiphospholipides.