Morphine as a cue in associative tolerance to morphine's analgesic effects.
This study examined the extent to which low doses of morphine paired explicitly with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test. The results indicated that tolerance development was not influenced by the pairing of low doses with high doses.
Cepeda-Benito
A
A
Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907-1364.
Tiffany
S T
ST
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003463:Cues; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006185:Habituation, Psychophysiologic; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D012044:Regression Analysis
D000700:Analgesics; D009020:Morphine