[Transient insulin-dependent diabetes mellitus with alpha-interferon therapy in chronic active hepatitis].
Since alpha-interferon has been introduced an efficient therapy of chronic active hepatitis has become available for the first time. Among some of the treated patients, however, alpha-interferon therapy causes typical side effects. Fever, chills, loss of weight, fatigue as well as arthralgia, myalgia, loss of concentration and hematologic side effects have to be mentioned in particular. We report the occurrence of a diabetes mellitus under alpha-interferon therapy. The metabolic disorder gradually normalized after 3 weeks of antidiabetic treatment, although the interferon medication had been continued. We consider this disorder to be an effect caused by the alpha-interferon. The underlying mechanism might be an insulin resistance or an autoimmunologic defect. For that reason, when administering alpha-interferon, we recommend regular analyses of the blood sugar level during the regular patient monitoring.
Gross
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I. Medizinische Klinik, Städtisches Krankenhaus Kemperhof, Koblenz.
Seifert
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D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced* / Q000188:drug therapy / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006442:Glycated Hemoglobin / Q000378:metabolism; D006509:Hepatitis B / Q000201:enzymology / Q000628:therapy*; D006513:Hepatitis B e Antigens / Q000097:blood; D006521:Hepatitis, Chronic / Q000201:enzymology / Q000628:therapy*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006513:Hepatitis B e Antigens; D007328:Insulin; D016898:Interferon-alpha
Passagerer insulinpflichtiger Diabetes mellitus unter Alpha-Interferontherapie bei chronisch aktiver Hepatitis.