Immunohistochemical detection of lactoferrin in different human glandular tissues with special reference to the exocrine pancreas.
The immunohistochemical detection of lactoferrin was carried out with the PAP technique on pancreatic tissue samples of 23 patients, operated for acute (13) or chronic (4) pancreatitis as well as for adenocarcinomas (6). In order to control our immunohistochemical technique and the antisera produced by us we studied some tissue samples of human mammary gland and parotis. We detected lactoferrin in the glands of parotis and mammae as well as of their secretions. In the pancreatic tissue we found a positive reaction only in granulocytes of inflammatory areas with the exception of a luminal reaction on the surface of acinar cells in one case of pancreatic adenocarcinoma. We would like to interpret our results with the hypothesis of granulocytic origin of immunochemically detectable lactoferrin in the pancreatic juice of patients, especially in cases of chronic pancreatitis.
Jonas
L
L
Department of Medical Biology, University of Rostock, Germany.
Krüger
B
B
Tessenow
W
W
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007781:Lactoferrin / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008895:Milk, Human / Q000737:chemistry; D010179:Pancreas / Q000033:anatomy & histology / Q000276:immunology / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000378:metabolism / Q000473:pathology; D010306:Parotid Gland / Q000378:metabolism / Q000473:pathology
D007781:Lactoferrin