Selective effects of some 5-lipoxygenase inhibitors on synovial interleukin-1 (IL-1) production compared with IL-1 synthesis inhibitors.
To determine the role of 5-LO regulation of IL-1 in synovial tissues, we examined the effects of 5-LO inhibitors compared with standard IL-1 synthesis inhibitors on IL-1 production by human synovial tissue explants from patients with inflammatory arthropathies. MK886, L-656,224, PF-5901, and tepoxalin all inhibited IL-1 production in concentrations up to 10 microM, whereas other 5-LO inhibitors (ICI-211,965, zileuton), as well as IL-1 synthesis inhibitors (IX-207,887, tenidap), were inactive. LT products, thus regulate IL-1 production and inhibition thereof is one strategy for inhibiting this cytokine.
Rainsford
K D
KD
Department of Biomedical Sciences, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.
Ying
C
C
Smith
F
F
D001168:Arthritis / Q000378:metabolism*; D001572:Benzofurans / Q000494:pharmacology; D003470:Culture Media; D046508:Culture Techniques; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D020024:Leukotriene Antagonists; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism*; D002722:Chlorobenzenes
D001572:Benzofurans; D003470:Culture Media; D006854:Hydrocortisone; D007211:Indoles; D007375:Interleukin-1; D020024:Leukotriene Antagonists; D016859:Lipoxygenase Inhibitors; D011804:Quinolines; C060893:MK-886; D002722:Chlorobenzenes; C049740:alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol; C055868:L 656224