title: Anorchia associated with gonadotropin deficiency.
abstract: We report an anorchic patient with normal male phenotype and 46,XY karyotype. Plasma levels of gonadotropins and testosterone were abnormally low. Administration of human chorionic gonadotropin caused no increase in plasma testosterone, and injection of luteinizing hormone-releasing hormone resulted in a lack of plasma gonadotropin response. Sex-determining region Y was detected by DNA studies of peripheral white blood cells. Laparoscopy revealed absence of testis, Wolffian and Müllerian derivatives. We discuss the embryology and hormone condition in an anorchic patient.
authors.affiliation: Department of Urology, Yamagata University School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: T
authors.initials: T
authors.lastname: Nakada
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Sawamura
mesh_terms: D000368:Aged; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006062:Gonadotropins / Q000172:deficiency*; D006801:Humans; D007621:Karyotyping; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013737:Testis / Q000002:abnormalities*; D013739:Testosterone / Q000172:deficiency
chemical_list: D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone