title: [Screening test of crude drug extract on anti-HIV activity].
abstract: The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 micrograms/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.
authors.affiliation: Osaka Prefectural Institute of Public Health, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamasaki
authors.forename: T
authors.initials: T
authors.lastname: Otake
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
authors.forename: N
authors.initials: N
authors.lastname: Ueba
authors.forename: Y
authors.initials: Y
authors.lastname: Kurokawa
authors.forename: K
authors.initials: K
authors.lastname: Shiota
authors.forename: T
authors.initials: T
authors.lastname: Yuge
mesh_terms: D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D013601:T-Lymphocytes; D014779:Virus Replication / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal