Mode of action of a topical steroid on immediate phase reaction after antigen challenge and nonspecific nasal hyperreactivity in nasal allergy.
This study compared the effects of 2-week administration of a topical steroid (fluticasone propionate [FP] 100 micrograms twice daily) with placebo in 28 patients with perennial nasal allergy who were allergic to house dust and mites in a double-blind randomized study. The number of inflammatory cells and decidual epithelial cells and concentrations of tryptase and eosinophil cationic protein in nasal lavages, and reactivity of the nasal mucosa to histamine and to antigen were investigated. The topical steroid, FP, significantly inhibited all of these assessments. The degree of improvement of nasal reactivity to histamine significantly correlated with the degree of decrease in eosinophil cationic protein levels.
Konno
A
A
Department of Otorhinolaryngology, School of Medicine, Chiba University, Japan.
Yamakoshi
T
T
Terada
N
N
Fujita
Y
Y
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000730:Androstadienes / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000941:Antigens / Q000008:administration & dosage*; D001798:Blood Proteins / Q000032:analysis; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D002648:Child; D053818:Chymases; D004311:Double-Blind Method; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000502:physiology; D005260:Female; D000068298:Fluticasone; D005938:Glucocorticoids; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D009297:Nasal Mucosa / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D009666:Nose / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000188:drug therapy* / Q000503:physiopathology; D012260:Ribonucleases; D012697:Serine Endopeptidases / Q000032:analysis; D007507:Therapeutic Irrigation; D013997:Time Factors; D053802:Tryptases
D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000941:Antigens; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D005938:Glucocorticoids; D006632:Histamine; D000068298:Fluticasone; D012260:Ribonucleases; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases