title: [Diffuse sclerosing papillary carcinoma of the thyroid. Report of a case].
abstract: The authors report the case of a 12-year-old girl presenting with a diffuse sclerosing papillary carcinoma of the thyroid. The diagnosis was made on a total thyroidectomy specimen three months after thyroid enlargement was detected. This child had previously been treated medically for thyroiditis because of an enlarged thyroid gland with serum antithyroid autoantibodies. A few cases have been described in the literature. Six morphologic findings define this variant of papillary carcinoma: a diffuse growth pattern involving one or both lobes of the thyroid, prominent fibrosis, heavy lymphocytic infiltration with germinal centers, large numbers of psammoma bodies, squamous metaplasia and papillae within cleft-like tissue spaces. Some authors stated that this variant has a poorer prognosis than the usual papillary carcinoma of the thyroid. However, in some series a few patients survive without local recurrence or distant metastasis at a mean follow-up period of more than 10 years. Immunohistochemical studies have shown high accumulation of S-100 protein positive dendritic cells. Such an infiltration has been correlated with a better prognosis.
authors.affiliation: Service d'Anatomie Pathologique B, Hôpital G. & R. Laënnec, Nantes.
authors.forename: C
authors.initials: C
authors.lastname: Sagan
authors.forename: M
authors.initials: M
authors.lastname: Fiche
authors.forename: P
authors.initials: P
authors.lastname: Cuilliere
authors.forename: J
authors.initials: J
authors.lastname: Leborgne
authors.forename: B
authors.initials: B
authors.lastname: Charbonnel
authors.forename: M F
authors.initials: MF
authors.lastname: Le Bodic
mesh_terms: D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D012598:Sclerosis; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy
vernacular_title: Carcinome papillaire sclérosant diffus de la thyroide. Présentation d'un cas.