title: Overexpression of PRAD1 in a mantle zone lymphoma patient with a t(11;22)(q13;q11) translocation.
abstract: The PRAD1 gene identified from the chromosome band 11q13 region was previously demonstrated to be overexpressed in cell lines with t(11;14)(q13;q32) translocation and was suggested to be a candidate BCL-1 gene. We report here one case of mantle zone lymphoma with a t(11;22)(q13;q11), a variant translocation at the BCL-1 locus, having the PRAD1 overexpression. By analogy with the c-myc gene in Burkitt's lymphoma and the BCL-2 gene in follicular lymphoma, this case supports strongly the idea that the PRAD1 is the candidate BCL-1 gene.
authors.affiliation: Laboratory of Chemotherapy, Aichi Cancer Centre Research Institute, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Seto
authors.forename: S
authors.initials: S
authors.lastname: Iida
authors.forename: T
authors.initials: T
authors.lastname: Aikawa
authors.forename: R
authors.initials: R
authors.lastname: Ueda
authors.forename: C
authors.initials: C
authors.lastname: Mikuni
mesh_terms: D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D019938:Cyclin D1; D016213:Cyclins / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D016213:Cyclins; D015513:Oncogene Proteins; D019938:Cyclin D1