title: [Intrahepatic cholangiocarcinoma: proposal of new macroscopic classification].
abstract: From the analysis of 19 resected intrahepatic cholangiocarcinoma (ICC) from 1980 to 1991 in the National Cancer Center Hospital, we classified them into three subcategories, mass-forming ICC, infiltrating ICC and papillary ICC, according to the morphologic pattern. Mass-forming ICC, which made an apparent mass lesion in the liver, showed a spread based on the intrahepatic metastasis with a frequent remnant hepatic recurrence. Infiltrating ICC caused a stricture or an obstruction of intrahepatic bile duct with a spread along the Glisson's capsule without forming a mass in the liver and yielded no remnant liver recurrence except for a local recurrence in the patient with positive surgical margin. Intraductal papillary ICC, which appeared a special type of ICC, developed a papillary projection into the ductal lumen. Three patients of mass-forming ICC and one of papillary ICC survived more than 5 years. The different biologic behaviour should be considered when formulating an operative procedure for each type of ICC.
authors.affiliation: Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Kosuge
authors.forename: K
authors.initials: K
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Takayama
authors.forename: S
authors.initials: S
authors.lastname: Yamasaki
authors.forename: H
authors.initials: H
authors.lastname: Ozaki
authors.forename: M
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000145:classification* / Q000473:pathology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000145:classification* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis