Intrapulmonary delivery of renin inhibitory peptides results in sustained release because of saturable transport.
Sheehy
A M
AM
Department of Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218.
Hoover
J L
JL
Rush
B D
BD
Wilkinson
K F
KF
Vidmar
T J
TJ
Ruwart
M J
MJ
D000042:Absorption; D000818:Animals; D001692:Biological Transport; D016503:Drug Delivery Systems; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014132:Trachea / Q000378:metabolism*; D000092502:Renin Inhibitors
D009842:Oligopeptides; D000092502:Renin Inhibitors; C085086:U 77436; C050898:ditekiren