Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia.
Deletions of DNA on chromosome 9p21-22 are frequently observed in cells derived from melanomas, gliomas, non-small cell lung cancers, and acute lymphoblastic leukemia. The minimal deletion shared by the latter three cancers extends from the interferon-alpha locus towards the centromere; its centromeric end is flanked by the gene encoding methylthioadenosine phosphorylase. We have determined that the telomeric end of the minimal homozygous deletion shared by two melanoma cell lines does not include the methylthioadenosine phosphorylase locus. Thus, a distinct region of DNA is lost in melanoma. The physical size of this region remains to be defined precisely, but it may extend over several million base pairs.
Coleman
A
A
Division of Biomedical Sciences, University of California, Riverside 92521.
Fountain
J W
JW
Nobori
T
T
Olopade
O I
OI
Robertson
G
G
Housman
D E
DE
Lugo
T G
TG
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D005910:Glioma / Q000235:genetics; D006801:Humans; D016898:Interferon-alpha / Q000235:genetics; D016899:Interferon-beta / Q000235:genetics; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics; D008545:Melanoma / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics; D014407:Tumor Cells, Cultured
D005819:Genetic Markers; D016898:Interferon-alpha; D016899:Interferon-beta