title: Circadian periodicity of urinary inhibitor of calcium oxalate crystallization in healthy Indians and renal stone formers.
abstract: The inhibitory activity (IA) of calcium oxalate crystallization was investigated in healthy Indians and renal stone formers. A marked circadian rhythm was observed in men and women of both groups. The rhythm pattern was similar on the basis of sex; however, it was different in stone formers as compared to normals. The acrophase for crystallization of calcium oxalate was observed, respectively, at 05.43 and 05.52 h in healthy men and women, and at 09.52 and 09.23 h in male and female renal stone formers. Moreover, the acrophase of percent inhibition by IA was observed at 17.44 and 17.52 h in healthy participants and at 21.52 and 21.27 h in male and female stone formers, respectively. Therefore, the acrophase suggests a highest risk of crystallization during the morning hours and a minimum one during the evening hours. The day-night rhythmic pattern of urinary calcium, magnesium and phosphorus is discussed in relation to the rhythm of IA.
authors.affiliation: Department of Biochemistry, G.S.V.M. Medical College, Kanpur, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Bansal
authors.forename: S K
authors.initials: SK
authors.lastname: Bansal
authors.forename: A K
authors.initials: AK
authors.lastname: Singh
authors.forename: A A
authors.initials: AA
authors.lastname: Mahdi
mesh_terms: D000293:Adolescent; D000328:Adult; D002129:Calcium Oxalate / Q000037:antagonists & inhibitors / Q000652:urine*; D002940:Circadian Rhythm; D003460:Crystallization; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000652:urine*; D008297:Male
chemical_list: D002129:Calcium Oxalate