Life-threatening thrombotic and haemorrhagic problems associated with silent myeloproliferative disorders.
Myeloproliferative disorders are well recognized as being associated with haemorrhage and thrombosis. We describe two cases, one of life-threatening haemorrhage and the other of thrombosis, in patients with normal peripheral blood counts and films, both of whom went on to develop overt manifestations of myeloproliferative disorders (CGL and essential thrombocythaemia) more than a year after their first presentation.
Vadher
B D
BD
Department of Haematology, University College Hospital, London.
Machin
S J
SJ
Patterson
K G
KG
Sukhu
C
C
Walker
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006474:Hemorrhagic Disorders / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000235:genetics; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications*; D010974:Platelet Aggregation / Q000502:physiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000235:genetics; D013927:Thrombosis / Q000209:etiology* / Q000235:genetics