Autoradiographic analysis of serotonin receptors and transporter in kindled rat brain.
While serotonin (5-HT) has been shown to be anticonvulsant in several types of experimentally induced seizures, 5-HT receptor binding has not been investigated in the kindling model of epilepsy. The present study examined the effects of amygdala kindling on two 5-HT receptor subtypes and on the 5-HT transporter in rat brain. Kindling induced a persistent bilateral increase in 5-HT1A binding in the dentate gyrus, while 5-HT1B receptors increased only in a delayed fashion. Binding to the 5-HT transporter was transiently decreased in dentate gyrus. In cerebral cortex, binding of the three ligands was unchanged. Alterations in 5-HT receptors and the 5-HT transporter may endogenously modulate kindled seizures. Additionally, autoradiography of adenosine A1 receptors revealed no change for these receptors in any brain region.
Clark
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M
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
Weiss
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SR
Post
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D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism; D000679:Amygdala / Q000502:physiology; D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D007457:Iodine Radioisotopes; D020120:Iodocyanopindolol; D007696:Kindling, Neurologic; D008297:Male; D017374:Paroxetine / Q000378:metabolism; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D011985:Receptors, Serotonin / Q000032:analysis / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism*; D014316:Tritium
D007457:Iodine Radioisotopes; D018047:Receptors, Purinergic P1; D011985:Receptors, Serotonin; D014316:Tritium; D017374:Paroxetine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D020120:Iodocyanopindolol; D010869:Pindolol