Biological monitoring of occupational exposure to toluene diisocyanate.
The study validated the use of urinary toluene diamine (TDA) in postshift samples as an indicator of preceding 8-h exposure to toluene diisocyanate (TDI). Nine workers exposed in TDI-based polyurethane foam production were studied. Their exposure levels varied in 8-h time-averaged samples from 9.5 to 94 micrograms/m3. The urinary TDA concentrations varied from 6.5 to 31.7 micrograms/g creatinine and they were linearly related to the atmospheric TDI levels. Approximately 20% of TDI is metabolized to diamines but their specificity is remarkable to the extent that by analysis for the 2,4- and 2,6-diamino isomers an idea of the percutaneous absorption may be had.
Maître
A
A
University Institute of Occupational Medicine and Ergonomics, Medical Faculty, La Tronche, France.
Berode
M
M
Perdrix
A
A
Romazini
S
S
Savolainen
H
H
D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008452:Maximum Allowable Concentration; D016273:Occupational Exposure / Q000009:adverse effects*; D010655:Phenylenediamines / Q000652:urine*; D012869:Skin Absorption; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000652:urine*
D000395:Air Pollutants, Occupational; D010655:Phenylenediamines; D014051:Toluene 2,4-Diisocyanate; C026942:2,6-diisocyanatotoluene; C010914:2,4-diaminotoluene