Expression of bcl-2 in small cell lung carcinoma cells.
We have investigated the expression of bcl-2 protein in a panel of small cell lung carcinoma (SCLC) cells lines. Five of six cell lines examined expressed relatively high levels of bcl-2 protein and transcripts. The bcl-2 expression in SCLC cells, however, was not always associated with myc expression. Since dysregulation of bcl-2 may be involved in the course of tumorigenesis and/or in the acquisition of drug resistance of tumor cells, the expression of bcl-2 in SCLC cells may become an important indicator in the prognosis or treatment of SCLC.
Ikegaki
N
N
Department of Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia 19104.
Katsumata
M
M
Minna
J
J
Tsujimoto
Y
Y
D018288:Carcinoma, Small Cell / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry*; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis*; D014407:Tumor Cells, Cultured
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc