title: A novel surface photo-graft polymerization method for fabricated devices.
abstract: This paper presents a new photo-graft polymerization method that permits surface modification of complex shaped devices. The principle is based on photochemistry of the dithiocarbamate group, as a polymerization initiator-transfer agent-terminator (iniferter), which is capable of photochemical dissociation into a radical pair. The procedure is as follows: first, coating of a photosensitive polymer on a substrate, and subsequent ultraviolet (UV) light irradiation in the presence of a monomer. The photosensitive polymer prepared was a radical copolymer of styrene and vinylbenzyl N,N-diethyldithiocarbamate. Surface graft polymerization of a water soluble monomer (N,N-dimethylacrylamide) on poly(ethylene terephthalate) pre-coated with the photosensitive polymer was achieved. Because the photopolymerization proceeded via a living radical polymerization, the control of molecular weight of the grafted polymer was feasible. This was quantitatively observed by graft polymerization on a quartz crystal microbalance (QCM) that can detect the weight increase with the sensitivity of ng-order. Two-dimensional patterning of cultured cells was demonstrated to show how surface grafted polymerization is limited on UV light irradiation portions with dimensionally micron order precision.
authors.affiliation: Department of Bioengineering, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Irie
mesh_terms: D000818:Animals; D002417:Cattle; D002448:Cell Adhesion / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D008422:Materials Testing; D008858:Microscopy, Phase-Contrast; D011093:Polyethylene Terephthalates; D011108:Polymers; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013859:Thiocarbamates; D014466:Ultraviolet Rays
chemical_list: D011093:Polyethylene Terephthalates; D011108:Polymers; D013859:Thiocarbamates