Consumption coagulopathy associated with shock in acute African swine fever.
We studied the evolution of shock using a comprehensive array of haematological tests in pigs infected with the highly virulent strain Malawi '83 (Lilongwe 20/1). A sudden onset of illness was observed between day 5 and 7 after inoculation with development of flush, episodes of epistaxis and melaena. Prior to these clinical signs, initiation of a consumption coagulopathy was demonstrated with loss of antithrombin III and plasminogen activity. Our findings indicate that during infection with this highly virulent strain the development of a consumption coagulopathy precedes and possibly contributes to shock, which results in haemorrhage and death.
Villeda
C J
CJ
Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
Williams
S M
SM
Wilkinson
P J
PJ
Viñuela
E
E
D000208:Acute Disease; D000357:African Swine Fever / Q000097:blood / Q000150:complications*; D000818:Animals; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D010976:Platelet Count; D012769:Shock / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology*
D001779:Blood Coagulation Factors