title: An evaluation of lesion detectability with cone-beam, fanbeam and parallel-beam collimation in SPECT by continuous ROC study.
abstract: To evaluate lesion detectability for clinical evaluation of cone-beam (CB), fanbeam (FB) and parallel-beam (PB) collimator sensitivity, experimentally acquired phantom data were used to assess the advantage of CB collimation over conventional collimation.
  
  
  METHODS
  Lesion detectability with CB, FB and PB collimation in SPECT was compared using a three-dimensional brain phantom and continuous receiver operating characteristic (CROC) analysis. A simulated cold lesion was located near the posterior portion of the thalamus. High count density scans of this phantom were acquired with CB, FB and PB collimators with similar resolution. These projections were scaled to count levels which reflected the measured sensitivities of the three collimators. Computer-generated Poisson noise was added to the projections to produce uncorrelated data sets. Images were reconstructed using a filtered backprojection algorithm. All reconstructions used a Hann filter with multiplicative attenuation correction. Each of seven trained observers viewed 288 sets of images and indicated the certainty of perceiving a cold lesion at a specified location by a rating of 0-100. Each image set contained four adjacent slices centered on the lesion to minimize partial volume effects. The program LABROC4 was used to fit CROC curves to individual observers' ratings. A t-test for paired data was performed on the individual areas.
  
  
  RESULTS
  The average areas (standard deviations) under CROC curves for CB, FB and PB were 0.89 (0.03), 0.83 (0.05) and 0.76 (0.04), respectively. The differences of the areas were statistically significant with all two-tailed p values < 0.02.
  
  
  CONCLUSIONS
  These results demonstrate that cold lesions in the posterior portion of the thalamus are best detected by images obtained using CB followed by FB and PB collimation.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: R J
authors.initials: RJ
authors.lastname: Jaszczak
authors.forename: T G
authors.initials: TG
authors.lastname: Turkington
authors.forename: C E
authors.initials: CE
authors.lastname: Metz
authors.forename: D R
authors.initials: DR
authors.lastname: Gilland
authors.forename: K L
authors.initials: KL
authors.lastname: Greer
authors.forename: R E
authors.initials: RE
authors.lastname: Coleman
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008961:Models, Structural; D012372:ROC Curve; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods*