title: Genetic polymorphism of orosomucoid (ORM) in populations of the United Kingdom, Indian subcontinent, and Cambodia.
abstract: The genetic variation of the human serum orosomucoid (ORM) was investigated by isoelectric focusing (IEF) followed by immunofixation in 15 different populations from East Midlands (United Kingdom), India, Sri Lanka, and Cambodia. Statistically significant differences were observed between various Asiatic and British populations, however differences within Asiatic and European populations were minor. The distribution of ORM1 alleles in populations investigated to date suggests an interesting east-west geographical cline. There is a suggestion that present day wide polymorphism at the ORM1 locus may be influenced by selection.
authors.affiliation: Department of Human Sciences, Loughborough University, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Mastana
authors.forename: R
authors.initials: R
authors.lastname: Jayasekara
authors.forename: P
authors.initials: P
authors.lastname: Fisher
authors.forename: R J
authors.initials: RJ
authors.lastname: Sokol
authors.forename: S S
authors.initials: SS
authors.lastname: Papiha
mesh_terms: D000483:Alleles; D002160:Cambodia; D006801:Humans; D007194:India; D007525:Isoelectric Focusing; D009961:Orosomucoid / Q000235:genetics*; D011110:Polymorphism, Genetic; D013188:Sri Lanka; D006113:United Kingdom
chemical_list: D009961:Orosomucoid