Kidney function in male and female rats chronically exposed to potassium dichromate.
Male and female Wistar rats were given 25 mg l-1 chromium (as potassium dichromate) in drinking water for 6 months. Lactate dehydrogenase, lysozyme, total proteins, N-acetyl-beta-D-glucosaminidase, albumin and beta 2-microglobulin (beta 2-m) were measured in 24-h urine after 3 and 6 months of exposure. Body and kidney weight and chromium excretion were also examined. Except for the chromium excretion, no statistically significant changes were observed in the exposed male rats. In female rats there were significant increases in the urinary excretion of albumin after 3 and 6 months of exposure and the urinary excretion of beta 2-m after 3 months of exposure.
Vyskocil
A
A
Département de Médecine du Travail et Hygiène du Milieu, Université de Montréal, Quebec, Canada.
Viau
C
C
Cízková
M
M
Truchon
G
G
D000818:Animals; D002857:Chromium / Q000652:urine; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D002857:Chromium; D011192:Potassium Dichromate