[Portal high flow state in dogs].
To make an animal model of portal high blood flow, a retrograde portacaval shunt (PCS) was designed. A regular side-to-side PCS with large stoma was performed first, followed by the ligation of the vena cava just proximal to the anastomosis. Thus the whole amount of blood of the lower half body turned its flow into the portal system. Portal hypervolemic model was made in 11 dogs, The portal hemodynamics was studied by duplex before operation and 10 days, 20 days and 4 months after operation. In the 10th day the 20th day and the 4th month after operation, laparotomy was done again for observing FPP, portal collateral circulation, and liver biopsy. The portal high flow state was maintained constantly and FPP elevated in different degrees. The portal collateral circulation and the pathological change of the liver was not remarkable. The function of the liver was not damaged. The portal high flow state was proved not to cause real clinical portal hypertension, while the elevation of portal resistance was the important initiating factor for formation of portal hypertension.
Huang
Y T
YT
First Teaching Hospital, Beijing Medical University.
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000209:etiology / Q000503:physiopathology*; D011167:Portacaval Shunt, Surgical; D011169:Portal Vein / Q000503:physiopathology*; D012039:Regional Blood Flow; D014655:Vascular Resistance; D014684:Venae Cavae / Q000601:surgery