title: Metallothionein I reduction of cytochrome c.
abstract: Using absorption spectroscopy we have found that metallothionein I at concentrations as low as 1 microM reduces ferricytochrome c. This reduction is more potent than that of another abundant intracellular thiol, glutathione. Also, oxidation of ferricytochrome c which had been reduced by metallothionein I occurs more slowly than when the reductant was glutathione. Over a pH range of 6 through 9 there is no variation in the initial rate of metallothionein I reduction of ferricytochrome c. These data demonstrate a potent interaction between metallothionein I and ferricytochrome c.
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore.
authors.forename: C
authors.initials: C
authors.lastname: Simpkins
authors.forename: P
authors.initials: P
authors.lastname: Eudaric
authors.forename: C
authors.initials: C
authors.lastname: Torrence
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D003574:Cytochrome c Group / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000737:chemistry; D008668:Metallothionein / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011817:Rabbits; D013053:Spectrophotometry / Q000379:methods
chemical_list: D003574:Cytochrome c Group; D008668:Metallothionein; D003576:Electron Transport Complex IV