Effect of hydroxypropyl-beta-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis.
The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl beta-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be effective. However, itraconazole at doses > or = 30 mg/kg/day solubilized in hydroxypropyl-beta-cyclodextrin markedly prolonged survival and a relationship between dose and survival was seen.
Hostetler
J S
JS
Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128.
Hanson
L H
LH
Stevens
D A
DA
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology; D003505:Cyclodextrins / Q000494:pharmacology*; D005079:Excipients; D005260:Female; D017964:Itraconazole / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D011092:Polyethylene Glycols; D012996:Solutions; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D005079:Excipients; D012996:Solutions; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D017964:Itraconazole; D011092:Polyethylene Glycols