Hippocalcin: a calcium-binding protein of the EF-hand superfamily dominantly expressed in the hippocampus.
Hippocalcin is a recently identified Ca(2+)-binding protein with three EF-hand structures, dominantly expressed in the hippocampal pyramidal layer. The complete amino acid sequence of hippocalcin deduced from the cDNA is composed of 195 residues, has a calculated molecular mass of 22,574 daltons, and has a striking sequence homology to those of visinin, recoverin, S-modulin, neurocalcins and neural visinin-like proteins. Hippocalcin binds 3 mol of Ca2+ per mol of protein at submicromolar Ca2+ levels, and associates the plasma membrane in a Ca(2+)-dependent manner. Hippocalcin is myristoylated at its NH2-terminal glycine residue, and this modification is a key event in terms of its membrane-association property.
Takamatsu
K
K
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
Noguchi
T
T
D000595:Amino Acid Sequence; D000818:Animals; D002135:Calcium-Binding Proteins / Q000096:biosynthesis / Q000378:metabolism*; D051597:Hippocalcin; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins
D002135:Calcium-Binding Proteins; C496691:HPCA protein, human; D009419:Nerve Tissue Proteins; D051597:Hippocalcin