Behavioral effects of the intraventricular administration of 5-HT and dopamine in the common marmoset (Callithrix jacchus).
The effects of IVT serotonin [5-hydroxytryptamine (5-HT)] and dopamine (DA) administration have been studied in rats and marmosets (Callithrix jacchus). In rats, 5-HT (114 and 170 micrograms/10 microliters) produced the same behavioral effects observed after IP administration of its precursors and agonists. The same doses of 5-HT used for rats produced only part of the behavioral effects in marmosets after IP administration of 5-HT precursors and agonists. Ataxia, vomiting, and decreased motor activity were observed, but not drowsiness or teeth-chattering. However, IVT administration of DA (400 micrograms/10 microliters dose) produced head movements or checking, ataxia, tongue out, and decreased motor activity. These findings differ from those observed after IP administration of l-DOPA and DA agonists, which increase motor activity.
Oliveira
M da P
Mda P
Departamento de Fisiologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.
Campos
M de F
Mde F
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002144:Callithrix; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D013045:Species Specificity; D014191:Tranylcypromine / Q000494:pharmacology
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D014191:Tranylcypromine; D004298:Dopamine