Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. II. Physico-chemical properties and structure elucidations.
Novel cytocidal compounds designated oxopropalines A, B, D, E and G were isolated from the fermentation of an actinomycete named Streptomyces sp. G324, a strain that also produced an antitumor antibiotic, lavendamycin. All these compounds possessed a beta-carboline chromophore. The structures of the oxopropalines were elucidated by several NMR spectral analyses and other spectroscopic experiments.
Abe
N
N
Pharmaceutical Research Laboratories, Sapporo Breweries, Ltd., Shizuoka, Japan.
Enoki
N
N
Nakakita
Y
Y
Uchida
H
H
Nakamura
T
T
Munekata
M
M
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013053:Spectrophotometry; D013302:Streptomyces / Q000737:chemistry*; D013308:Streptonigrin / Q000031:analogs & derivatives / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D002243:Carbolines; C085034:oxopropaline A; C085035:oxopropaline B; C085036:oxopropaline D; C085037:oxopropaline E; C085038:oxopropaline G; D013308:Streptonigrin; C034566:lavendamycin