title: Amides and formamidines with antinociceptive activity (note II).
abstract: Forty amides, formamidines and trifluoromethylsulfonylamides bearing on the nitrogen a cyclohexyl residue, eventually 2-substituted, were prepared and tested for analgesic activity against a chemical stimulus. Good activity was exhibited by amides 9, 11 and 28, by formamidine 34, as well as by triflyamide 40. Eleven additional compounds exhibited a moderate activity.
authors.affiliation: Istituto di Analitica Farmaceutica, Università di Sassari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pau
authors.forename: G
authors.initials: G
authors.lastname: Boatto
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.forename: M
authors.initials: M
authors.lastname: Palomba
authors.forename: M
authors.initials: M
authors.lastname: Nicolai
authors.forename: F
authors.initials: F
authors.lastname: Sparatore
authors.forename: M V
authors.initials: MV
authors.lastname: Varoni
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice
chemical_list: D000577:Amides; D000578:Amidines; D000700:Analgesics; C077922:formamidine