Biology of monoclonal antibodies in tumor therapy.
This paper gives an overview of the biology of monoclonal antibodies in tumor therapy. The complexity of the monoclonal antibody concept is discussed with functional aspects on tumor antigen, antigen binding, Ig isotypes and effector mechanisms involved.
Janson
C H
CH
Clinical Research Infection and Immunology, Astra Arcus AB, Södertälje, Sweden.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000628:therapy*
D000911:Antibodies, Monoclonal