title: Induction of heat-shock proteins enhances myocardial and endothelial functional recovery after prolonged cardioplegic arrest.
abstract: The aim of this study was to investigate the role of heat-shock proteins after heat-shock stress on the post-ischemic recovery of cardiac mechanical and endothelial function following a prolonged cardiac arrest. Isolated working rat hearts were subjected to a cardioplegic arrest for 4 hours at 4 degrees C. Three groups (n = 8 in each) were studied: (1) control, (2) sham-treated, and (3) heat-shocked rats. Postischemic recovery of cardiac output and endothelial function (as percent of preischemic control values) was 57.8% +/- 2.8% and 20.8% +/- 3.9% in group 1, 50.9% +/- 4.0% and 26.3% +/- 5.9% in group 2, and 74.0% +/- 2.4% and 51.2% +/- 8.0% in group 3, respectively. Both postischemic myocardial and endothelial function were improved by heat stress.
authors.affiliation: Cardiothoracic Surgery Department, National Heart and Lung Institute, London, England.
authors.forename: M
authors.initials: M
authors.lastname: Amrani
authors.forename: J
authors.initials: J
authors.lastname: Corbett
authors.forename: N J
authors.initials: NJ
authors.lastname: Allen
authors.forename: J
authors.initials: J
authors.lastname: O'Shea
authors.forename: S Y
authors.initials: SY
authors.lastname: Boateng
authors.forename: A J
authors.initials: AJ
authors.lastname: May
authors.forename: M J
authors.initials: MJ
authors.lastname: Dunn
authors.forename: M H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D000818:Animals; D002302:Cardiac Output; D006324:Heart Arrest, Induced; D006359:Heat Exhaustion / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats
chemical_list: D006360:Heat-Shock Proteins; D009569:Nitric Oxide