Cervical HPV infection among HIV-infected prostitutes addicted to hard drugs.
An investigation into the prevalence of human papilloma virus (HPV) infection, abnormal cervical cytology and the relationship between HIV- and HPV infection was done in a group of intravenously (IV) and non-IV drug-using prostitutes. From July 1991 through May 1992, hard drug-addicted prostitutes attending a sexually-transmitted-disease (STD) clinic in Amsterdam were recruited. A questionnaire was administered to obtain demographic characteristics, and medical and STD history. Apart from routine STD examination, cervical scrapes for cytology and samples for HPV DNA detection by polymerase chain reaction (PCR) were collected. Some of the women included in this study also participated in HIV studies among drug users. Their data on HIV- and immunologic status could be combined. A total of 121 women entered the study; 25 women were HIV-seropositive, 44 women were HIV-negative, and the HIV status of 52 women was unknown. All 25 HIV-positive women had normal Pap smears, two of the 44 HIV-negative women had a Pap smear III A, and in the HIV-unknown group, two women with Pap III A and one with Pap III B were found. Eight of the 25 (32%) HIV-positive women were HPV DNA-positive, three of the 44 (7%) HIV-negative women and 10/52 (19%) of the HIV-unknown group. Logistic regression analysis showed that in the total group, presence or cervical HPV DNA was associated with HIV infection (order ratio [OR] for HIV-positives 7.8, 95% confidence interval [CI] 1.8 to 34.6) and with diagnosis of condylomata acuminata at entry to the study (OR 7.5, 95% CI 1.5 to 36.5).(ABSTRACT TRUNCATED AT 250 WORDS)
Van Doornum
G J
GJ
Department of Public Health, Municipal Health Service of Amsterdam, The Netherlands.
Van den Hoek
J A
JA
Van Ameijden
E J
EJ
Van Haastrecht
H J
HJ
Roos
M T
MT
Henquet
C J
CJ
Quint
W G
WG
Coutinho
R A
RA
D000328:Adult; D002584:Cervix Uteri / Q000382:microbiology / Q000473:pathology; D003218:Condylomata Acuminata / Q000150:complications; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D009426:Netherlands; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D011477:Sex Work; D012749:Sexually Transmitted Diseases / Q000276:immunology; D019966:Substance-Related Disorders / Q000150:complications*; D016176:T-Lymphocyte Subsets; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology*; D002577:Uterine Cervical Diseases / Q000150:complications / Q000453:epidemiology*
D004279:DNA, Viral