Anti-lipopolysaccharide activity of histatins, peptides from human saliva.
Histatins are histidine-rich polypeptides secreted in human saliva. They were found to inhibit lipopolysaccharide (LPS)-mediated gelation of Limulus amoebocyte lysate, and to reverse the anti-complement action of LPS or lipid A. Histatins also gave precipitate bands in agarose gels with various LPS. The results indicate that histatins neutralized the activity of LPS by binding to the lipid A moiety of LPS.
Sugiyama
K
K
Department of Pharmacology, Okayama University Dental School, Japan.
D004926:Escherichia coli; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008033:Limulus Test; D008050:Lipid A / Q000032:analysis / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000032:analysis / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa; D012463:Saliva / Q000737:chemistry / Q000502:physiology*; D012471:Salivary Proteins and Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D012475:Salmonella; D000099053:Histidine-Rich Glycoprotein
D008050:Lipid A; D008070:Lipopolysaccharides; D011506:Proteins; D012471:Salivary Proteins and Peptides; D000099053:Histidine-Rich Glycoprotein