title: Effects of thyroxine and thyroparathyroidectomy on circadian wheel running in rats.
abstract: Thyroparathyroidectomized (TPX) and thyroidectomized male rats display shorter free-running activity periods and enhanced activity levels. These experiments were designed to determine whether this effect is due to the loss of thyroid hormones. The running wheel activity of 36 male rats, 19 TPX and 17 sham operated, was studied. The animals were kept in constant conditions for 7 weeks to obtain baseline data. Half the rats were then injected SC with capsules containing T4, while the other half were injected with blanks. All animals were then allowed to free-run undisturbed for another 8-9 weeks. TPX rats displayed significantly shorter baseline periods (average difference: 0.26 h) and heightened activity. Thyroxine treatment significantly lengthened TPX animals' cycles (average increase: 0.28 h) but did not affect intact rats' circadian rhythms. Thyroxine did, however, significantly decreased the activity levels of both TPX and sham-operated rats. These findings indicate that changes in TPX rats' activity cycles are caused by a reduction in thyroid hormones and that thyroxine acts on activity rhythms and levels by different mechanisms.
authors.affiliation: Department of Psychology, University of Pennsylvania, Philadelphia 19104.
authors.forename: D L
authors.initials: DL
authors.lastname: McEachron
authors.forename: C L
authors.initials: CL
authors.lastname: Lauchlan
authors.forename: D E
authors.initials: DE
authors.lastname: Midgley
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D016105:Parathyroidectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine