title: Use of a bovine hemoglobin preparation in the treatment of cyclic ovarian hemorrhage in a miniature horse.
abstract: Anemia that was secondary to ovarian hemorrhage in a 4-year-old miniature horse mare was treated prior to laparotomy with polymerized ultrapurified bovine hemoglobin (PUBH). Two previous whole-blood transfusions had resulted in acute transfusion reaction, and a suitable blood donor could not be found among 9 horses, necessitating use of the blood substitute. Subsequent blood typing revealed the mare to be Aa-negative, with allo-antibodies against Aa in serum. Serious adverse reactions were not observed after infusion of PUBH, and the mare recovered. Although the safety and efficacy of using PUBH in horses has not been established, PUBH may prove to be an excellent alternative to whole-blood transfusions, when indicated.
authors.affiliation: Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
authors.forename: A D
authors.initials: AD
authors.lastname: Maxson
authors.forename: U
authors.initials: U
authors.lastname: Giger
authors.forename: C R
authors.initials: CR
authors.lastname: Sweeney
authors.forename: M
authors.initials: M
authors.lastname: Tomasic
authors.forename: J E
authors.initials: JE
authors.lastname: Saik
authors.forename: W J
authors.initials: WJ
authors.lastname: Donawick
authors.forename: E G
authors.initials: EG
authors.lastname: Cothran
mesh_terms: D000740:Anemia / Q000209:etiology / Q000628:therapy / Q000662:veterinary; D000818:Animals; D001788:Blood Grouping and Crossmatching / Q000662:veterinary; D001794:Blood Pressure; D001802:Blood Substitutes / Q000627:therapeutic use*; D002302:Cardiac Output; D002417:Cattle; D004971:Estrus; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006406:Hematoma / Q000150:complications / Q000628:therapy / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D006465:Hemoperitoneum / Q000209:etiology / Q000662:veterinary; D006470:Hemorrhage / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D010049:Ovarian Diseases / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D010507:Periodicity
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins