title: Immediate and long-term prognostic significance of a first anterior versus first inferior wall Q-wave acute myocardial infarction. Secondary Prevention Reinfarction Israeli Nifedipine Trial (SPRINT) Study Group.
abstract: Of 3,981 patients with a first Q-wave acute myocardial infarction (AMI), 1,929 (48%) had an anterior and 1,724 (43%) an inferior wall AMI. These 2 groups were well-matched with respect to age, gender and relevant history. The in-hospital mortality rate was 18%, and the 1- and 5-year post-discharge mortality rates were 9 and 25%, respectively, in patients with anterior wall AMI compared with the corresponding rates of 11, 6 and 19% in those with inferior wall AMI (p < 0.0001 for each category). The frequency of recurrent nonfatal AMI in the year after the index AMI was 8% in the patients with anterior wall AMI compared with 4% in those with inferior wall AMI (p < 0.0001). By multiple logistic regression analysis of events, anterior wall AMI was an independent predictor of in-hospital mortality only. The findings indicate that the anatomic location of a Q-wave AMI influences immediate and short-term survival of patients with a first Q-wave AMI.
authors.affiliation: Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Behar
authors.forename: B
authors.initials: B
authors.lastname: Rabinowitz
authors.forename: M
authors.initials: M
authors.lastname: Zion
authors.forename: H
authors.initials: H
authors.lastname: Reicher-Reiss
authors.forename: E
authors.initials: E
authors.lastname: Kaplinsky
authors.forename: E
authors.initials: E
authors.lastname: Abinader
authors.forename: J
authors.initials: J
authors.lastname: Agmon
authors.forename: Y
authors.initials: Y
authors.lastname: Friedman
authors.forename: Y
authors.initials: Y
authors.lastname: Kishon
authors.forename: A
authors.initials: A
authors.lastname: Palant
mesh_terms: D000368:Aged; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology / Q000517:prevention & control; D009543:Nifedipine / Q000627:therapeutic use; D011379:Prognosis; D012008:Recurrence; D013997:Time Factors
chemical_list: D009543:Nifedipine