Effect of iron-limiting conditions on growth of clinical isolates of Acinetobacter baumannii.
Different clinical isolates of Acinetobacter baumannii, typed by plasmid profile, were able to grow in iron-chelated medium by secreting iron-regulated siderophores. This iron-scavenging phenotype was associated with the production of iron-repressible catechol. Siderophore utilization bioassays showed the presence of 2,3-dihydroxybenzoic acid in the growth medium, and neither enterobactin nor aerobactin was detected in culture supernatants obtained under iron-deficient conditions.
Actis
L A
LA
Department of Microbiology and Immunology, School of Medicine, Oregon Health Sciences University, Portland 97201-3098.
Tolmasky
M E
ME
Crosa
L M
LM
Crosa
J H
JH
D000150:Acinetobacter / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D010957:Plasmids; D017262:Siderophores / Q000378:metabolism; D014774:Virulence
D017262:Siderophores; D007501:Iron