[The effect of interleukin-2 on rosette formation and its dependence on the serotonin level].
The analogy of the immunomodulating effects of the mediators of functionally coupled immune and serotoninergic systems was demonstrated in CBA mice immunized with sheep erythrocytes. Both agents in low doses stimulated and in high doses suppressed the response of the host to the antigen. Combined use of IL-2 and serotonin in optimal doses of similar action was shown to revert the effect into the opposite one. These data attest to the relationship of serotonin and IL-2 in the process of immunomodulation and to the importance of the balance of the substances in the environment at the moment of exposure to the antigenic information.
Eliseeva
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D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003404:Creatinine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007114:Immunization; D007376:Interleukin-2 / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins / Q000494:pharmacology; D012397:Rosette Formation; D012701:Serotonin / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D007376:Interleukin-2; D011994:Recombinant Proteins; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D003404:Creatinine
Vliianie interleĭkina-2 na rozetkoobrazovanie i ego zavisimost' ot urovnia serotonina.