title: Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome.
abstract: The human SOS1 and SOS2 genes encode proteins that control GDP-->GTP exchange on ras proteins and are involved in signal transduction by tyrosine kinase receptors. In situ hybridization shows that SOS1 maps to 2p22-->p16 and SOS2 to 14q21-->q22 in the human genome.
authors.affiliation: Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, Valbonne, France.
authors.forename: P
authors.initials: P
authors.lastname: Chardin
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D011905:Genes, ras; D015894:Genome, Human; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics*; D010957:Plasmids; D020664:Son of Sevenless Proteins
chemical_list: D008565:Membrane Proteins; D020664:Son of Sevenless Proteins