[A new natural model of elevated anxiety in rats].
The levels of anxiety were determined in male Wistar rats using a complex multiparameter method for evaluating anxiety-phobic states in rats based on ranged scale. The effects of psychotropic drugs differed in rats with innate high and low levels of anxiety. Anxiolytics sodium valproate (200 mg/kg), phenazepam (0.05 mg/kg) and diazepam (0.1 and 0.6 mg/kg) reduced anxiety in rats with innate high level of anxiety and prevented increase of anxiety induced by saline in rats with innate low level of anxiety. Pentylenetetrazol (10 mg/kg) and haloperidol at a large dose (0.5 mg/kg) increased anxiety in rats with either high or low innate levels of anxiety. However sodium lactate (600 mg/kg) increased anxiety only in rats with innate high level of anxiety. Haloperidol at a small dose (0.01 mg/kg) and melipramin (10 mg/kg) were uneffective in rats with innate high level of anxiety. Results believed the rats with innate high level of anxiety to be used as a new natural animal model of anxiety.
Rodina
V I
VI
Krupina
N A
NA
Kryzhanovskiĭ
G N
GN
D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D010698:Phobic Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D011619:Psychotropic Drugs / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar / Q000523:psychology*; D013045:Species Specificity
D011619:Psychotropic Drugs
Novaia estestvennaia model' povyshennoĭ trevozhnosti u krys.