Flurbiprofen in the prevention and treatment of experimental gingivitis.
A clinical trial was undertaken to examine the effects of a potent cyclooxygenase inhibitor, flurbiprofen, on both developing and established gingivitis in humans. 21 subjects with healthy gingiva abstained from all oral hygiene procedures for 21 days. 7 subjects were prescribed flurbiprofen, 50 mg b.d. beginning from baseline and a control group (Cl, n = 14) were given placebo. Gingival redness and bleeding on probing were assessed at baseline, 7, 14 and 21 days. Crevicular fluid (GCF) samples were also taken to determine concentrations of PGE2, TxB2 and LTB4 at baseline and at 21 days. Results show that flurbiprofen significantly inhibited the development of redness and bleeding (p < 0.001) effects which were associated with a significant inhibition of TxB2 (p < 0.05). There were no apparent flurbiprofen effects on GCF-PGE2 or GCF-LTB4 during this 21-day gingivitis, model To assess the effects of flurbiprofen on established experimental gingivitis, the model was extended to 28 days. On day 21, the Cl group was subdivided into 2 groups of 7 subjects. One group was prescribed flurbiprofen (50 mg b.d.) for 7 days and controls (C2) continued to take placebo. All subjects continued to abstain from tooth cleaning. Pretreatment (day 21) and post-treatment (day 28) comparisons showed that flurbiprofen again significantly inhibited bleeding (p < 0.001), but did not affect redness. Control subjects demonstrated a significant elevation in gingival bleeding on day 28, and this was associated with significant rises in GCF-PGE2 (p < 0.001), GCF-TxB2 (p < 0.01) and GCF-LTB4 (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Heasman
P A
PA
Department of Operative Dentistry, Dental School University of Newcastle upon Tyne, England.
Offenbacher
S
S
Collins
J G
JG
Edwards
G
G
Seymour
R A
RA
D000328:Adult; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D005883:Gingival Crevicular Fluid / Q000276:immunology; D005891:Gingivitis / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis
D007975:Leukotriene B4; D013929:Thromboxane B2; D005480:Flurbiprofen; D015232:Dinoprostone