[Mianserin: pharmacology and clinical aspects of an effective antidepressive agents].
Among the non-tricyclic "newer" antidepressants, mianserin is one of the most thoroughly investigated agents. In the present review its chemical and pharmacological properties, as well as clinically relevant aspects of the use of this antidepressant are discussed. In the first instance, mianserin is indicated for the treatment of depressive illness associated with anxiety and agitation, even including severe forms of depression. Mianserin is characterised by a favourable side effect profile and low toxicity, and thus offers distinct advantages in the treatment of he elderly, as also in patients with a suicidal tendency.
Demling
J
J
Psychiatrische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.
D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008803:Mianserin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009638:Norepinephrine / Q000378:metabolism
D008803:Mianserin; D009638:Norepinephrine
Mianserin: Pharmakologie und Klinik eines bewährten Antidepressivums.