Dual immunologic property of S-100 protein in normal eyes and eyes with retinoblastoma: a histopathological and immunohistochemical study of 88 cases.
To ascertain the cell types expressing S-100 protein in eyes with retinoblastoma, a follow-up study was made on 88 formalin-fixed and paraffin-embedded retinoblastoma specimens histopathologically and immunohistochemically, using antibodies against S-100 protein. In normal retinas and morphologically normal retinas with retinoblastoma, both astrocytes and ganglion cells were stained positively for S-100 protein. In the retinoblastomas, not only the reactive astrocytes in most cases, but also large tumor cells with large cell bodies, prominent nucleoli and well-differentiated figures were positive for S-100 proteins in 2 cases. These large tumor cells were thought to be neuronal and were called ganglion-like cells because they were morphologically and immunohistochemically compatible with the large ganglion cells in normal retina. The results indicate that in eyes with retinoblastoma, S-100 protein has both neuronal and glial immunologic properties and could have a limited value as a glial marker for the histogenesis study of retinoblastoma.
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Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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D001253:Astrocytes / Q000276:immunology; D014408:Biomarkers, Tumor; D005134:Eye Neoplasms / Q000276:immunology* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D009457:Neuroglia / Q000276:immunology; D012160:Retina / Q000276:immunology*; D012165:Retinal Ganglion Cells / Q000276:immunology; D012175:Retinoblastoma / Q000276:immunology* / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis*
D014408:Biomarkers, Tumor; D009418:S100 Proteins