Modulation of cartilage destruction in murine arthritis with anti-IL-1 antibodies.
One of the early events in murine antigen-induced arthritis is the generation of IL-1 in the inflamed joint. We investigated the role of IL-1 in the acute phase of the arthritic process by selective blockage of IL-1 bioactivity by treatment with neutralizing antibodies. Pretreatment with anti-IL-1 antibodies moderately suppressed joint swelling. The decrease in chondrocyte proteoglycan synthesis seen in the acute phase of arthritis was prevented by treatment with anti-IL-1 antibodies. IL-1 does not appear to be a major contributor to the accelerated breakdown of articular cartilage in this model. The major impact of anti-IL-1 antibodies was the prevention of proteoglycan synthesis inhibition which clearly reduced articular cartilage depletion by maintaining normal proteoglycan synthesis.
van de Loo
F A
FA
Department of Rheumatology, University Hospital St. Radboud, Nijmegen, The Netherlands.
Arntz
O J
OJ
Otterness
I G
IG
van den Berg
W B
WB
D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology*; D007116:Immunization, Passive; D007375:Interleukin-1 / Q000276:immunology* / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007719:Knee Joint / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009500:Neutralization Tests; D009504:Neutrophils; D011509:Proteoglycans / Q000378:metabolism
D007375:Interleukin-1; D015850:Interleukin-6; D011509:Proteoglycans