title: Factor VII deficiency with intracranial hemorrhage: a case report.
abstract: Factor VII deficiency is an autosomal recessive hereditary disorder characterized by a normal partial thromboplastin time and a prolonged prothrombin time. Definite diagnosis of this condition requires a specific Factor VII assay. Its quite uncommon occurrence in the newborn was first described by Alexander and associates in 1951. A one-day-old male, full-term newborn was presented here with skin pallor, respiratory distress and bitemporal bulging masses noted immediately after birth. Computed tomography scan of the brain revealed a subgaleal hematoma and subarachnoid hemorrhage. Laboratory studies revealed prolonged prothrombin time and a Factor VII level less than 1%. Literature on the clinical manifestation and management of Factor VII deficiency is reviewed briefly.
authors.affiliation: Department of Pediatric, Veterans General Hospital-Taichung, Taiwan, R.O.C.
authors.forename: S C
authors.initials: SC
authors.lastname: Chen
authors.forename: T K
authors.initials: TK
authors.lastname: Chang
authors.forename: C S
authors.initials: CS
authors.lastname: Chi
authors.forename: S G
authors.initials: SG
authors.lastname: Shu
mesh_terms: D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D005167:Factor VII / Q000032:analysis; D005168:Factor VII Deficiency / Q000150:complications*; D005817:Genetic Counseling; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011517:Prothrombin Time; D011859:Radiography
chemical_list: D005167:Factor VII