title: Relative blood damage in the three phases of a prosthetic heart valve flow cycle.
abstract: Blood flow through a prosthetic heart valve operating in a ventricular assist device can be subdivided into three phases: a) forward flow through an open valve, b) rapid valve closure, and c) regurgitant back flow through a closed valve. Recent studies of fluid stresses in the Penn State Electric Left Ventricular Assist Device (PS LVAD) operating under physiologic conditions indicate that Reynolds stresses of possibly hemolytic magnitude may exist in the valve area. Although several studies have been made of the fluid stresses seen in forward flow through an open valve, few have looked at valve closure or backflow, and none have related these stresses directly to blood damage. In this study, novel in vitro blood flow loops were developed to allow for the separate analysis of the three flow phases of a Bjork-Shiley monostrut Delrin disk valve operating in a PS LVAD. Forward flow through fully open aortic and mitral valves and backflow through closed valves are studied separately in flow loops driven by a roller pump with the LVAD acting as a valve housing and compliance vessel. Valve closure is investigated with a PS LVAD operating in a low volume mock circulatory loop characterized by cavitation potential through stroboscopic videography of this mock loop, using saline as the working fluid. Rate of hemolysis, characterized by the index of hemolysis, IH, is determined for each of the three flow loops charged with fresh porcine blood.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Applied Research Library, Pennsylvania State University, University Park 16802.
authors.forename: T C
authors.initials: TC
authors.lastname: Lamson
authors.forename: G
authors.initials: G
authors.lastname: Rosenberg
authors.forename: D B
authors.initials: DB
authors.lastname: Geselowitz
authors.forename: S
authors.initials: S
authors.lastname: Deutsch
authors.forename: D R
authors.initials: DR
authors.lastname: Stinebring
authors.forename: J A
authors.initials: JA
authors.lastname: Frangos
authors.forename: J M
authors.initials: JM
authors.lastname: Tarbell
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D006350:Heart Valve Prosthesis; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006452:Hemoglobinometry; D006461:Hemolysis; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012212:Rheology; D013552:Swine