title: [Is regression of coronary sclerosis possible?].
abstract: Randomized studies with sequential coronary arteriographies have clearly documented that aggressive lipid-lowering therapy and change in life style can reduce progression and produce a modest regression of coronary artery lesions. The changes in the extent of a stenosis are determined by the level of cholesterol and LDL cholesterol achieved during treatment. Three of the randomized studies have shown that the lipid-lowering intervention has not only a beneficial influence on the coronary arteriographic lesions, but the number of clinical events is reduced as well. The calcium blockers nifedipine and nicardipine do not influence progression and regression but reduce the de novo appearance of coronary stenoses, either expressed as number of lesions per patient or as percentage of patients with new stenoses.
authors.affiliation: Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: H P
authors.initials: HP
authors.lastname: Krayenbühl
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000178:diet therapy / Q000517:prevention & control*; D004041:Dietary Fats; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
chemical_list: D000924:Anticholesteremic Agents; D002121:Calcium Channel Blockers; D004041:Dietary Fats; D002784:Cholesterol
vernacular_title: Ist eine Regression der Koronarsklerose möglich?