Somatic currents contribute to frequency-dependent spike-broadening in supraoptic neuroendocrine cells.
Voltage-gated K and Ca currents were recorded in acutely dissociated neuroendocrine cells of the supraoptic nucleus. The effect of repeated activation of the currents by trains of (10) voltage pulses over a range of pulse-repetition frequencies were examined. There was a significant reduction of K-current amplitude and a significant increase of Ca-current amplitude during trains with high repetition frequencies. Frequency-dependent changes in K and Ca conductances may contribute to frequency-dependent spike-broadening which is exhibited during bursts of action potentials generated by these neurons.
O'Regan
M H
MH
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317.
Cobbett
P
P
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004594:Electrophysiology; D015640:Ion Channel Gating / Q000502:physiology; D008297:Male; D009490:Neurosecretory Systems / Q000166:cytology / Q000502:physiology*; D015221:Potassium Channels / Q000378:metabolism*; D051381:Rats; D013495:Supraoptic Nucleus / Q000166:cytology / Q000502:physiology*
D015220:Calcium Channels; D015221:Potassium Channels