Amiprilose in the prevention of restenosis after coronary intervention in a swine model.
BACKGROUND
Amiprilose hydrochloride is a synthetic carbohydrate with anti-inflammatory and antiproliferative properties. This study tested the potential benefit of amiprilose in preventing coronary artery restenosis in a swine model.


METHODS
The swine restenosis model was prepared using Hanford miniature swine made atherosclerotic with coronary abrasion, high-fat and high-cholesterol feeding, and intracoronary stenting. Eighteen animals were randomized to receive amiprilose, 100 mg/kg body weight orally twice per day (n = 9), or no amiprilose (n = 9) beginning 5 days before stenting and continuing through 4 weeks until sacrifice. Presacrifice quantitative coronary angiography and postsacrifice histologic examination revealed the degree of intimal proliferation.


RESULTS
Coronary angiography revealed no difference in percentage-diameter stenosis between the amiprilose and control groups (left anterior descending artery [LAD], 46% +/- 10% vs 44% +/- 17%; circumflex artery [CFX], 43% +/- 21% vs 42% +/- 15%; right coronary artery [RCA], 37% +/- 11% vs 34% +/- 9%; P = not significant [NS]), respectively, or in change in lumen diameter from poststenting to presacrifice (LAD, -1.0 +/- 0.4 mm vs -1.1 +/- 0.7 mm; CFX, -1.2 +/- 0.8 mm vs -1.0 +/- 0.7 mm; RCA, -1.1 +/- 0.4 mm vs -1.0 +/- 0.4 mm; P = NS). Morphometric histologic analysis likewise showed no difference in percentage-area stenosis (LAD, 55% +/- 14% vs 55% +/- 15%; CFX, 53% +/- 15% vs 54% +/- 12%; RCA, 39% +/- 17% vs 39% +/- 20%; P = NS) or in maximal intimal thickness.


CONCLUSIONS
Amiprilose hydrochloride did not prevent coronary intimal proliferation in this swine model of restenosis.
Grinstead
W C
WC
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
Rodgers
G P
GP
Mazur
W
W
Cromeens
D M
DM
French
B A
BA
West
M S
MS
Raizner
A E
AE
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017023:Coronary Angiography / Q000187:drug effects*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000473:pathology; D004036:Diet, Atherogenic; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012008:Recurrence; D012266:Ribose / Q000031:analogs & derivatives; D015607:Stents; D013552:Swine; D013556:Swine, Miniature
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012266:Ribose; D005944:Glucosamine; C018424:amiprilose