Serum corticosteroid-binding globulin levels in children undergoing heart surgery.
Serum corticosteroid-binding globulin (CBG) levels were measured in children (mean age 4 years) during heart surgery. Considerable decrease in CBG level occurred between baseline examination (416 +/- 39 nM) and the day of surgery (314 +/- 30 nM). Relatively simple closed heart surgery did not influence CBG level with maximal cortisol level being 20 +/- 4 micrograms/dl. Open heart surgery under conditions of profound hypothermia (26 C, without extracorporeal circulation) caused dramatic lowering of CBG level, particularly striking after resuscitation (180 +/- 20 nM). At the same time cortisol level reached extremely high values (78 +/- 8 micrograms/dl). These data suggest that CBG is likely to play an important role in pituitary-adrenal response to surgery under severe conditions of hypothermia and cardiac arrest.
Tinnikov
A A
AA
Institute of Cytology and Genetics of the Russian Academy of Sciences, Novosibirsk.
Legan
M V
MV
Pavlova
I P
IP
Litasova
E E
EE
Ivanova
L N
LN
D006348:Cardiac Surgical Procedures; D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000097:blood / Q000601:surgery; D006324:Heart Arrest, Induced; D006345:Heart Septal Defects, Ventricular / Q000097:blood / Q000601:surgery; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007036:Hypothermia, Induced; D014156:Transcortin / Q000378:metabolism*
D014156:Transcortin; D006854:Hydrocortisone