title: Effects of alprazolam on influenza virus infection in stressed mice.
abstract: The review of the literature shows that stress can adversely affect influenza A virus infection. In this report, we study the effects of chronic alprazolam (1 mg/kg/day), a central benzodiazepine agonist anxiolytic, on the influenza A (PR-8/34) virus specific immune injury in mice exposed to a chronic auditory stressor. Treatment with alprazolam resulted in a significant reduction of stress-induced increase of virus titters and pulmonary vascular permeability. A correlation with the lethality of mice was also observed.
authors.affiliation: Neuroimmunology-University of Santiago (NIMUS), Hospital de Conxo, Santiago de Compostela, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Freire-Garabal
authors.forename: J L
authors.initials: JL
authors.lastname: Balboa
authors.forename: J C
authors.initials: JC
authors.lastname: Fernandez-Rial
authors.forename: M J
authors.initials: MJ
authors.lastname: Núñez
authors.forename: A
authors.initials: A
authors.lastname: Belmonte
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000525:Alprazolam / Q000494:pharmacology*; D000818:Animals; D002199:Capillary Permeability / Q000502:physiology; D009980:Influenza A virus / Q000472:pathogenicity; D008168:Lung / Q000382:microbiology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000401:mortality / Q000523:psychology*; D011650:Pulmonary Alveoli / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications / Q000401:mortality / Q000523:psychology*; D015996:Survival Rate
chemical_list: D000525:Alprazolam