Differentiation of chronic lesions after stroke in stroke-prone spontaneously hypertensive rats using diffusion weighted MRI.
Apparent diffusion coefficients (ADCs) of tissue water were determined in chronic brain lesions of a rat stroke model, stroke-prone spontaneously hypertensive rats and compared with histology. ADCs increased in the order control < edema < gliosis < cyst. The differences between individual groups were statistically significant. The increase in ADC is thought to mainly reflect a relative increase in the extracellular space in brain tissue. ADC values may be a clinically useful parameter for tissue characterization.
Takahashi
M
M
Research Department, Nihon Schering, Osaka, Japan.
Fritz-Zieroth
B
B
Chikugo
T
T
Ogawa
H
H
D000818:Animals; D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000473:pathology*; D002908:Chronic Disease; D004058:Diffusion; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR