title: Hormone production by the postmenopausal ovary in cases of benign ovarian neoplasia.
abstract: OBJECTIVE
  The objective of this study was to determine whether hormone production by postmenopausal ovaries containing benign ovarian tumors differed from that of normal postmenopausal ovaries.
  
  
  METHODS
  The sera of 32 postmenopausal patients were assayed before and after bilateral oophorectomy for estrone, 17 beta-estradiol, androstenedione, testosterone, and dehydroepiandrosterone sulfate. The data from all patients as a group were analyzed, followed by analysis of the data from 15 patients with normal ovaries separately from the remaining 17 patients who had nonfunctioning, benign ovarian tumors.
  
  
  RESULTS
  For patients with benign ovarian tumors there was a statistically significant drop in estrone (from a presurgical level of 55.8 +/- 46.3 pg/ml to a postoperative level of 29.9 +/- 10.2 pg/ml, p < 0.03) and 17 beta-estradiol (from 18.6 +/- 14.1 pg/ml preoperatively to 9.8 +/- 3.8 pg/ml postoperatively, p < 0.02). For postmenopausal woman with normal ovaries there was no significant drop in estrone or 17 beta-estradiol after bilateral oophorectomy. There was a statistically significant drop in testosterone and androstenedione after bilateral oophorectomy both for women with normal ovaries and for those with benign tumors. No significant differences in dehydroepiandrosterone sulfate were noted in either group.
  
  
  CONCLUSIONS
  These data suggest that, although normal postmenopausal ovaries have not been demonstrated to secrete clinically significant amounts of estrogen, those that contain benign ovarian tumors do secrete small but significant amounts of estrone and 17 beta-estradiol. Both tumor-containing and normal ovaries secrete the androgens androstenedione and testosterone, this secretion not being significantly influenced by the presence of a tumor.
authors.affiliation: Department of Obstetrics and Gynecology, Queens, Hospital Center, Jamaica, New York.
authors.forename: V L
authors.initials: VL
authors.lastname: Seltzer
authors.forename: S
authors.initials: S
authors.lastname: Deutsch
authors.forename: F
authors.initials: F
authors.lastname: Benjamin
mesh_terms: D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood* / Q000503:physiopathology; D010053:Ovary / Q000378:metabolism*; D017698:Postmenopause / Q000097:blood* / Q000502:physiology
chemical_list: D012739:Gonadal Steroid Hormones