title: [Depression and climacteric. Clinical and neuroendocrinological aspects].
abstract: The clinical and neuroendocrine evidences that link depression with menopause are reviewed. Climacteric is associated with depressive symptoms, but these do not form a definite depressive entity. Depression would be due to the disregulation of brain noradrenergic and serotoninergic systems. Gonadal steroids modify the neurotransmission of these systems and may influence the mood regulations. Depression appearing in the climacteric period must be treated with antidepressants. The depressive symptoms associated to estrogen deficit may improve with hormonal substitution.
authors.affiliation: Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Universidad de Chile, Santiago de Chile.
authors.forename: H
authors.initials: H
authors.lastname: Silva
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology; D002979:Climacteric / Q000523:psychology*; D003863:Depression / Q000503:physiopathology / Q000523:psychology*; D004967:Estrogens / Q000008:administration & dosage; D005260:Female; D006801:Humans; D013256:Steroids / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D004967:Estrogens; D013256:Steroids
vernacular_title: Depresión y climaterio. Aspectos clínicos y neuroendócrinos.