Reproductive insufficiency in the male rat with adenine-induced chronic renal failure.
The effect of adenine-induced chronic renal failure on the male reproductive system was studied using male Wistar rats. On the 30th experimental day, serum creatinine and urea nitrogen were elevated in adenine-treated rats. Body weight ratio of the testes and serum levels of gonadotropins (luteinizing hormone and follicle-stimulating hormone) in adenine-treated rats were similar to those in the controls. Serum testosterone level was reduced in adenine-induced uremic rats, but serum concentrations of 17 alpha-hydroxyprogesterone and androstenedione were increased in the uremic group. These results suggest that adenine-induced chronic renal failure reduces testicular function by suppressing 17 beta-hydroxysteroid oxidoreductase which converts androstenedione to testosterone.
Adachi
Y
Y
Department of Urology, Yamagata University School of Medicine, Japan.
Sasagawa
I
I
Nakada
T
T
D019326:17-alpha-Hydroxyprogesterone; D000225:Adenine / Q000502:physiology; D000735:Androstenedione / Q000097:blood; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006908:Hydroxyprogesterones / Q000097:blood; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000096:biosynthesis* / Q000097:blood
D006908:Hydroxyprogesterones; D013739:Testosterone; D000735:Androstenedione; D019326:17-alpha-Hydroxyprogesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003404:Creatinine; D000225:Adenine