title: Necator americanus in inbred mice: a re-evaluation of primary infection kinetics.
abstract: The course of a primary Necator americanus infection was studied in the lungs and small intestines of syngeneic mice. Following percutaneous infection no difference in initial larval establishment in the lungs was found between male BALB/c, NIH or B10.G mice. However, significant differences in the subsequent kinetics of infection were demonstrated between the BALB/c and NIH strains. Lung worm burdens declined more slowly in NIH mice than in BALB/c strain. Surprisingly, however, a greater proportion of larvae remaining in the lungs of BALB/c mice, 9 days p.i., were trapped than in NIH mice. Nevertheless, establishment in the small intestines of the BALB/c strain was consistently greater than in NIH mice. Host immunosuppression resulted in increased larval retention in the lungs of both the BALB/c and NIH strains as well as in the small intestines of BALB/c mice. Treatment with hydrocortisone acetate did not increase intestinal worm burdens in NIH mice. The data presented suggest that, in this complex, dynamic model system, designation of 'susceptible' and 'resistant' strains is inappropriate. The factors underlying the observed strain differences in resistance to infection are discussed.
authors.affiliation: Department of Life Science, University of Nottingham, UK.
authors.forename: L M
authors.initials: LM
authors.lastname: Timothy
authors.forename: J M
authors.initials: JM
authors.lastname: Behnke
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007165:Immunosuppression Therapy; D007421:Intestine, Small / Q000469:parasitology; D007700:Kinetics; D007814:Larva / Q000469:parasitology; D008124:Locomotion; D008168:Lung / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology / Q000469:parasitology; D008815:Mice, Inbred Strains / Q000276:immunology / Q000469:parasitology*; D017221:Necator americanus / Q000254:growth & development* / Q000276:immunology; D009332:Necatoriasis / Q000276:immunology / Q000469:parasitology*; D012867:Skin / Q000469:parasitology; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
chemical_list: C021650:hydrocortisone acetate; D006854:Hydrocortisone