[Biosensors comprising DNA as receptive component].
Most of biosensors rely on proteins, including enzymes and antibodies. In addition to such proteins, DNA is also an important host molecule in biological recognition. Sensors comprising DNA, single and/or double strands, as a receptive component would be useful in detecting complimentary DNA as well as DNA-binding molecules and ions. In this article, coupling methods for DNA with solid substrates are discussed. New strategies for detecting the interaction of analytes with the immobilized DNA are reviewed. The DNA duplex modified electrode is proposed to have a potential for determining binding constants of a series of DNA-binding drugs.
Maeda
M
M
Department of Chemical Science and Technology, Kyushu University.
D000818:Animals; D015374:Biosensing Techniques; D004247:DNA; D018076:DNA, Complementary / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis; D004566:Electrodes; D005796:Genes
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D004247:DNA