Support for the shape concept of lipid structure based on a headgroup volume approach.
Headgroup volumes of seven dioleoyl lipid species, calculated from covalent radii, are shown to correlate linearly (r = 0.95) with the ability of those lipids to alter the midpoint temperature of the lamellar to inverted hexagonal phase transition (L alpha-->HII) of a 95 mole fraction percent phosphatidylethanolamine matrix. The results illustrate the utility of the shape concept and basic considerations of headgroup volume as a predictive tool for the determination of lipid structure.
Lee
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YC
Department of Pathology and Cell Biology, Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Taraschi
T F
TF
Janes
N
N
D055592:Biophysical Phenomena; D001703:Biophysics; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D010712:Phosphatidic Acids / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D013816:Thermodynamics
D010712:Phosphatidic Acids; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C057561:1-palmitoyl-2-oleoylphosphatidylethanolamine