title: Tissue polypeptide antigen in bronchogenic carcinoma.
abstract: Serum concentrations of tissue polypeptide antigen (TPA) were examined by an immunoradiometric technique in 114 patients with bronchogenic carcinoma and in 55 patients with noncancerous lung diseases. The sensitivity of TPA examination in bronchogenic carcinoma was 67.5% and was increased in advanced stages of the disease. No statistically significant differences were observed between histologic types of bronchogenic carcinoma. In nonmalignant lung diseases, elevated levels of TPA were observed in 21.8% of patients. TPA is of little value in the diagnosis of bronchogenic carcinoma; however, it may be useful as an auxiliary criterion for staging.
authors.affiliation: 1st Chest Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Zatloukal
authors.forename: A
authors.initials: A
authors.lastname: Glagolicová
authors.forename: M
authors.initials: M
authors.lastname: Linhart
authors.forename: A
authors.initials: A
authors.lastname: Sebes
authors.forename: P
authors.initials: P
authors.lastname: Hencl
authors.forename: O
authors.initials: O
authors.lastname: Mĕricka
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000473:pathology; D002283:Carcinoma, Bronchogenic / Q000097:blood* / Q000473:pathology; D018287:Carcinoma, Large Cell / Q000097:blood / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay / Q000379:methods; D008171:Lung Diseases / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010455:Peptides / Q000097:blood*; D012016:Reference Values; D019396:Tissue Polypeptide Antigen
chemical_list: D014408:Biomarkers, Tumor; D010455:Peptides; D019396:Tissue Polypeptide Antigen