Comparative effects of the anticholinesterase drug galanthamine on the mechanical activity of isolated rat jejunum and ileum.
1. The effects of cumulatively applied galanthamine hydrobromide (0.1-300 microM) on the mechanical activity of isolated proximal jejunum and distal ileum were studied. 2. Galanthamine was found to increase the spontaneous mechanical activity and exert by itself an enhancement of the smooth muscle tone in the two segments, both effects being more pronounced in ileum than in jejunum. 3. The galanthamine-induced augmentation of the spontaneous mechanical activity was tetrodotoxin (TTX)-sensitive, whereas the contractile effect of the drug on the tone was TTX-insensitive in both segments. 4. The present results showed not only quantitative differences in the tonic effects of galanthamine in both intestinal segments but they suggest some qualitative differences in cholinergic neuronal control along the gastro-intestinal tract.
Mutafova-Yambolieva
V N
VN
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Yamboliev
I A
IA
Mihailova
D N
DN
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005702:Galantamine / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013779:Tetrodotoxin / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D005702:Galantamine; D013779:Tetrodotoxin