The impact of vitamins A,C,E, and selenium compound on prevention of liver cancer in rats.
A study was initiated to determine the impact of vitamins A, C, E, and selenium compound (Se) on the prevention of liver cancer. Sixty animals were fed a diet with or without these vitamins followed by aflatoxin B treatment for a period of 24 months. Most of the animals fed a diet devoid of vitamins developed liver cancer, while none or only a few of the animals given vitamins suffered during this period. We suggest that vitamins can inhibit liver cancer by inducing hepatic microsomal enzymes that metabolise aflatoxins to noncarcinogenic products.
Nyandieka
H S
HS
Department of Biochemistry, College of Health Sciences, University of Nairobi.
Wakhisi
J
J
D016604:Aflatoxin B1; D000633:Aminopyrine N-Demethylase / Q000187:drug effects; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D004121:Dimethyl Sulfoxide; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology / Q000627:therapeutic use*; D014801:Vitamin A / Q000494:pharmacology / Q000627:therapeutic use*; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D014801:Vitamin A; D014810:Vitamin E; D003577:Cytochrome P-450 Enzyme System; D016604:Aflatoxin B1; D000633:Aminopyrine N-Demethylase; D012643:Selenium; D001205:Ascorbic Acid; D004121:Dimethyl Sulfoxide