title: [Pharmacological studies on human urinary kallidinogenase (SK-827): effects on cerebral metabolism].
abstract: We investigated the effects of human urinary kallidinogenase (SK-827) on cerebral metabolism in normal and infarcted rabbits. SK-827 did not influence cerebral glucose and oxygen uptake in normal rabbits. In infarcted rabbits, cerebral glucose and oxygen uptake significantly decreased. SK-827 tended to inhibit the decrease of cerebral blood flow, and significantly inhibited the decrease of cerebral glucose and oxygen uptake in infarcted rabbits. Thus, SK-827 improved cerebral glucose metabolism in infarcted rabbits.
authors.affiliation: Mie Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nagano
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tomoguri
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Tsurumi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007610:Kallikreins / Q000494:pharmacology* / Q000652:urine; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits
chemical_list: D007610:Kallikreins; D005947:Glucose