The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia?
By analogy with epidermal growth factor and EGF-like repeats, the P-domain, or trefoil motif, is a characteristic shuffled module containing six invariant cysteine residues that forms the basic unit for a family of mucin-associated peptides. These P-domain peptides are potential modulators of cell growth and they are also expressed under certain pathological conditions. Furthermore, P-domains have been found as components of extracellular mosaic proteins including certain mucins, where they are thought to play a role either in protein-protein or in lectin-like interactions.
Hoffmann
W
W
Max-Planck-Institut für Psychiatrie, Abteilung Neurochemie, Martinsried, FRG.
Hauser
F
F
D000595:Amino Acid Sequence; D000818:Animals; D003424:Crohn Disease / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006133:Growth Substances / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009077:Mucins; D009092:Mucous Membrane / Q000378:metabolism; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3
D006133:Growth Substances; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; C099037:TFF3 protein, rat; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3