Haemorrhagic bullae induced by oral anticoagulants.
A 77-year-old patient developed haemorrhagic bullae on her fingers 30 months after initiation of anti-coagulation treatment with warfarin sodium for chronic atrial fibrillation and mitral insufficiency. The bullae resolved 10 days after discontinuation of the medication. Two weeks after initiation of sintrom, (3-alpha-(4-nitrophenyl)-beta-acetylethyl-4-hydroxy coumarin), the lesions recurred and resolved again upon cessation of the drug. This adverse skin reaction has not been hitherto reported.
Elis
A
A
Department of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Lishner
M
M
Lang
R
R
Savin
H
H
Ravid
M
M
D000074:Acenocoumarol / Q000009:adverse effects; D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D014859:Warfarin / Q000009:adverse effects
D000925:Anticoagulants; D014859:Warfarin; D000074:Acenocoumarol