205Bi/206Bi cyclotron production from Pb-isotopes for absorption studies in humans.
Pb(p, xn) thick target excitation functions were measured in the energy range 10-38 MeV in order to optimize the production of isotopically pure radiobismuth from natPb, 206Pb, and 207Pb. Additionally, the decay of Po-isotopes from deuteron irradiation of natural bismuth (209Bi) was exploited for radiobismuth production. 205Bi was produced from 206Pb at 20 MeV with only 2% of 206Bi at 4 weeks post irradiation. Bismuth compounds as used in the treatment of peptic ulcer were labeled with 205Bi for absorption studies in animals and subjects.
Fischer
R
R
Abteilung Medizinische Biochemie, Universitätskrankenhaus Eppendorf, Hamburg, Germany.
Wendel
J
J
Dresow
B
B
Bechtold
V
V
Heinrich
H C
HC
D001729:Bismuth / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D017357:Cyclotrons; D005243:Feces / Q000737:chemistry*; D006801:Humans; D010865:Pilot Projects; D011868:Radioisotopes / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D011868:Radioisotopes; D001729:Bismuth