New norcucurbitacin and heptanorcucurbitacin glucosides from Fevillea trilobata.
From the MeOH extract of the seeds of Fevillea trilobata (Cucurbitaceae) were isolated fevicordin A glucoside [1], cayaponoside B [2], cayaponoside D [3], a new norcucurbitacin glucoside, and a new heptanorcucurbitacin glucoside. The structure of the new norcucurbitacin glucoside, andirobicin A glucoside, was established as 29-nor-1,2,3,4,5,10-dehydro-25-methoxy-2-O-beta-D-glucopyranosyl- 3,16 alpha,20R,22 xi-tetrahydroxy-11-oxocucurbit-23-ene [4], and that of the novel heptanorcucurbitacin glucoside, andirobicin B glucoside, as 22,23,24,25,26,27,29-heptanor-1,2,3,4,5,10-dehydro-2-O-beta-D-g luc opyranosyl-3,16 alpha-dihydroxycucurbita-11,20-dione [5].
Valente
L M
LM
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
Gunatilaka
A A
AA
Glass
T E
TE
Kingston
D G
DG
Pinto
A C
AC
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C085145:andirobicin A glucoside; C085146:andirobicin B glucoside