[Effect of xiao chaihu decoction on experimental alkaline reflux gastritis in rats].
The effects of Xiao Chaihu Decoction (XCHD) on alkaline reflux gastritis and gastric secretion in rats was observed.


RESULTS
(1) 5g/kg, 20 g/kg of XCHD might markedly inhibit the gastric lesion induced by gastric feeding of sodium taurocholate; (2) 5g/kg, 20g/kg of XCHD might significantly prevent the gastric lesion induced by gastric feeding of intestinal juice; (3) On chronic reflux gastritis model induced by spring-expanded pylorus after 4 or 8 weeks, 4g/kg-20g/kg of XCHD might lower the incidence of gastritis, and reduce the intragastric bile acid; (4) 5g/kg and 20g/kg of XCHD might significantly inhibit the secretion of gastric juice and acid as well as the activity of pepsin. The results suggested that XCHD had anti-reflux gastritis effect.
Gu
H O
HO
Dept. of Pharmacology, Beijing College of TCM.
Hou
J Y
JY
D000818:Animals; D001655:Bile Reflux / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005756:Gastritis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D010434:Pepsin A / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013656:Taurocholic Acid
D004365:Drugs, Chinese Herbal; D013656:Taurocholic Acid; D010434:Pepsin A