The effect of aspirin, paracetamol and analgin on pharmacokinetics of chloroquine.
The effect of Aspirin, paracetamol and analgin on the kinetic profile of a single oral dose of chloroquine was studied in 8 healthy subjects. Aspirin did not alter the kinetic parameters of chloroquine whereas paracetamol and analgin significantly enhanced the Cmax and AUC0-alpha of chloroquine (P < 0.01, < 0.05 respectively).
Raina
R K
RK
Department of Pharmacology and Therapeutics, Government Medical College, Jammu, Tawi.
Bano
G
G
Amla
V
V
Kapoor
V
V
Gupta
K L
KL
D000082:Acetaminophen / Q000494:pharmacology*; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D002738:Chloroquine / Q000097:blood / Q000493:pharmacokinetics*; D004177:Dipyrone / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008954:Models, Biological
D000082:Acetaminophen; D004177:Dipyrone; D002738:Chloroquine; D001241:Aspirin