title: Comparison of the bronchodilator efficacy of nebulized pirenzepine and ipratropium bromide in patients with airway obstructive lung disease.
abstract: Ipratropium bromide (IB) is a non-selective muscarinic antagonist, whose bronchodilator efficacy has been shown in reversible and irreversible obstructive airway diseases. Pirenzepine is a M1 receptor antagonist and effective in vagally-induced bronchoconstriction. To investigate the bronchodilator efficacy of nebulized pirenzepine, we compared nebulized pirenzepine with nebulized IB and nebulized isotonic saline (placebo). Eighteen patients with reversible and 18 patients with irreversible obstructive airway disease were studied. Nebulized isotonic saline (placebo), 100 mcg nebulized pirenzepine and 125 mcg nebulized IB were given on three consecutive days. Spirometry was performed prior to nebulization and repeated at 5, 30, 60, 90 and 120 minutes following nebulized medication. A dose of 125 mcg IB resulted in a significant increase in FEV1 in patients with both reversible or irreversible bronchoconstriction (p < 0.00001, p < 0.03). IB at the same dose resulted in an increase in FVC in patients with irreversible bronchoconstriction (p < 0.001) and an increase in FEF25-75 in patients with reversible bronchoconstriction (p < 0.0003). Pirenzepine therapy resulted in no significant change in the same parameters. It is concluded that nebulized pirenzepine at a dose of 100 mcg does not have bronchodilator effect in patients with reversible or irreversible bronchoconstriction.
authors.affiliation: Marmara University, Faculty of Medicine, Department of Pulmonary Medicine, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Ceyhan
authors.forename: T
authors.initials: T
authors.lastname: Celikel
authors.forename: S
authors.initials: S
authors.lastname: Simsir
authors.forename: B
authors.initials: B
authors.lastname: Kandemir
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage / Q000627:therapeutic use*; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D010890:Pirenzepine / Q000008:administration & dosage / Q000627:therapeutic use*; D013147:Spirometry
chemical_list: D010890:Pirenzepine; D009241:Ipratropium