Hemofiltration modifies complement activation after extracorporeal circulation in infants.
Complement and fibrinolytic factors were measured in 9 infants undergoing hemofiltration immediately after cardiopulmonary bypass in an attempt to reduce activation of these systems. Plasma levels of C3a, C5a, and terminal complement complexes increased during bypass by 460%, 85%, and 745%. Plasma levels were reduced after hemofiltration in 8 of the 9 infants, and C3a and C5a fractions were recovered in the ultrafiltrate. The observed activation of the fibrinolytic system seemed to be unaltered by hemofiltration. Fibrinolytic factors were not filtered. Our study shows that increased concentrations of complement factors in the plasma after bypass in infants may be reduced by hemofiltration.
Andreasson
S
S
Department of Pediatric Anesthesia, East Hospital, Gothenburg, Sweden.
Göthberg
S
S
Berggren
H
H
Bengtsson
A
A
Eriksson
E
E
Risberg
B
B
D003167:Complement Activation / Q000502:physiology*; D015926:Complement C3a / Q000378:metabolism; D015936:Complement C5a / Q000378:metabolism; D005112:Extracorporeal Circulation; D005342:Fibrinolysis / Q000502:physiology; D006330:Heart Defects, Congenital / Q000601:surgery*; D006440:Hemofiltration; D006801:Humans; D007223:Infant
D015926:Complement C3a; D015936:Complement C5a