Strategies for rescue of retinal photoreceptor cells.
A variety of genetic and environmental factors cause degeneration of retinal photoreceptors. This review focuses on current strategies to rescue defective, but still viable, rods and cones, including transplantation of normal retinal pigment epithelium cells, corrective gene therapy, administration of survival/growth factors, protection from the damaging effects of light, and dietary supplementation of vitamin A.
Milam
A H
AH
Department of Ophthalmology RJ-10, University of Washington, Seattle 98195.
D000818:Animals; D017690:Cell Transplantation; D015316:Genetic Therapy; D006801:Humans; D008027:Light / Q000009:adverse effects; D010786:Photoreceptor Cells / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D010857:Pigment Epithelium of Eye / Q000166:cytology; D012162:Retinal Degeneration / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D014801:Vitamin A / Q000627:therapeutic use
D014801:Vitamin A