[Effect of ciprofloxacin therapy in duration of bacterial excretion in acute salmonella gastroenteritis].
In view of the increasing incidence of non-typhoid salmonellosis, the effect of early treatment with ciprofloxacin on the permanent elimination of salmonella was evaluated. In a prospective study, 14 patients with non-typhoid salmonellosis were treated with 2 x 500 mg/d ciprofloxacin for 10 days within 5 days of onset of symptoms. Relapse occurred in 4/14 (29%) patients 2-3 weeks after termination of therapy. Using sero- and ribotyping, relapse was confirmed and reinfection ruled out in 4/4 patients. Furthermore, ribotyping suggested double infection in one patient. Development of resistance to ciprofloxacin was not observed. We conclude that the use of antimicrobial chemotherapy to treat non-institutional salmonellosis in immunocompetent patients cannot generally be recommended but must be considered carefully in each case. Indications for ciprofloxacin therapy in the treatment of non-typhoid salmonellosis are discussed.
Funke
G
G
Institut für Medizinische Mikrobiologie, Universität Zürich.
Nemes
P
P
Lüthy-Hottenstein
J
J
Altwegg
M
M
D000328:Adult; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D005243:Feces / Q000382:microbiology*; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012475:Salmonella / Q000187:drug effects; D012480:Salmonella Infections / Q000188:drug therapy* / Q000382:microbiology
D002939:Ciprofloxacin
Einfluss einer Ciprofloxacin-Therapie auf die Ausscheidedauer bei akuter Salmonellen-Gastroenteritis.