[Conjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide].
A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.
Larionova
N I
NI
Gladysheva
I P
IP
Topchieva
I N
IN
Kazanskaia
N F
NF
D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D004852:Epoxy Compounds / Q000378:metabolism*; D005027:Ethylene Oxide / Q000378:metabolism*; D019272:Leukocyte Elastase; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011108:Polymers; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000378:metabolism*
D004852:Epoxy Compounds; D011108:Polymers; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; D005027:Ethylene Oxide; C009068:propylene oxide
Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.