d-alpha-tocopherol control of cell proliferation.
Uncontrolled cell growth is at the basis of neoplastic proliferation and arteriosclerotic lesions. In vitro proliferation of vascular smooth muscle cells, Balb c/3T3 fibroblasts, retinal neuroepithelial cells and neuroblastoma cells is inhibited by d-alpha-tocopherol. On the contrary Chinese hamster ovary cells, osteosarcoma cells and macrophages are not sensitive. PDGF-BB activated proliferation is highly d-alpha-tocopherol sensitive while lysophosphatidic acid induced growth is poorly inhibited. d-beta-Tocopherol, an analogue of d-alpha-tocopherol, with similar antioxidant properties, does not inhibit proliferation. Protein kinase C activity is inhibited by d-alpha-tocopherol but not by d-beta-tocopherol, suggesting a central role of this enzyme in the control of cell proliferation by d-alpha-tocopherol. Activation of the transcription activation complex AP-1 (but not NFKB) is prevented by d-alpha-tocopherol and not by d-beta-tocopherol.
Azzi
A
A
Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
Boscoboinik
D
D
Chatelain
E
E
Ozer
N K
NK
Stäuble
B
B
D016475:3T3 Cells; D000818:Animals; D016466:CHO Cells; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D006224:Cricetinae; D006801:Humans; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D009130:Muscle, Smooth / Q000201:enzymology; D016328:NF-kappa B / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology*
D008934:Mitogens; D016328:NF-kappa B; D016755:Proto-Oncogene Proteins c-jun; D014810:Vitamin E; D011493:Protein Kinase C