title: [Allergy and bronchial reactivity in children and adolescents from Copenhagen].
abstract: The relationship between bronchial responsiveness and the results of a skin prick test was studied in 527 children and adolescents from Copenhagen. All participants completed a questionnaire concerning birth weight, breastfeeding, month of birth, month of examination, allergic symptoms in themselves or their parents. Furthermore, skin prick test reactivity to nine common aero-allergens, lung function, serum IgE, and bronchial responsiveness to histamine and exercise were measured. A total of 158 (30%) subjects showed signs of allergy (defined as a positive reaction to the skin prick test), of whom 53 (10%) subjects had positive skin reactivity and 105 subjects had moderate skin reactivity; 366 (70%) subjects had no signs of allergic disease as measured by the pride test. The most important marker for the degree of bronchial responsiveness was asthma (p < 0.001), month of examination (p < 0.01) and allergy (skin reactivity to one or more allergens) (p < 0.05). Furthermore, the degree of bronchial responsiveness to inhaled histamine was significantly related to a history of asthma in two first degree relatives (p < 0.01) and the skin reactivity to house-dust mites (p < 0.01), whereas the degree of bronchial responsiveness to exercise was significantly associated with the level of serum IgE (p < 0.05), month of birth (p < 0.001) and birth weight (p < 0.05). In conclusion, allergy is an important risk factor for the presence of increased degree of bronchial responsiveness to inhaled histamine and to exercise.
authors.affiliation: Respirationsfysiologisk laboratorium, medicinsk afdeling B, Rigshospitalet, København.
authors.forename: V
authors.initials: V
authors.lastname: Backer
authors.forename: C S
authors.initials: CS
authors.lastname: Ulrik
authors.forename: K K
authors.initials: KK
authors.lastname: Hansen
authors.forename: E M
authors.initials: EM
authors.lastname: Laursen
authors.forename: A
authors.initials: A
authors.lastname: Dirksen
authors.forename: N
authors.initials: N
authors.lastname: Bach-Mortensen
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016535:Bronchial Hyperreactivity / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D001985:Bronchial Provocation Tests; D002648:Child; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D012307:Risk Factors; D012882:Skin Tests; D011795:Surveys and Questionnaires
vernacular_title: Allergi og bronkial reaktivitet hos børn og unge fra København.