The development of behavioral sensitization to apomorphine is blocked by MK-801.
The effects of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), on the development of sensitization to the mixed dopamine receptor agonist, apomorphine were examined. Rats pretreated with MK-801 (0.25 mg/kg) prior to 2.0 mg/kg apomorphine failed to show a progressive sensitization to the activating effect of apomorphine across six preexposure sessions, nor did they show enhanced activity relative to control rats in response to 0.5 mg/kg apomorphine, given alone, during a subsequent test for sensitization. These results support the view that MK-801 interferes with long-term neural changes underlying sensitization to stimulant drugs.
Druhan
J P
JP
Department of Psychology, Concordia University, Montréal, Québec, Canada.
Jakob
A
A
Stewart
J
J
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003213:Conditioning, Psychological; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D016291:Dizocilpine Maleate; D001058:Apomorphine