title: Indicators of hypoxia in cerebrospinal fluid of hydrocephalic children with suspected shunt malfunction.
abstract: We used high performance liquid chromatography to determine the concentration of purine metabolites in the cerebrospinal fluid of three hydrocephalic children with a history of shunt malfunction. Hypoxanthine and xanthine levels were high in comparison with controls. We consider these purines to be valuable indicators of disturbance of neuronal metabolism following the sustained rise in intracranial pressure caused by shunt valve malfunction.
authors.affiliation: Department of Pediatrics, Hospital General de Galicia, Clínico Universitario, Santiago de Compostela, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Castro-Gago
authors.forename: S
authors.initials: S
authors.lastname: Rodríguez-Segade
authors.forename: F
authors.initials: F
authors.lastname: Camiña
authors.forename: A
authors.initials: A
authors.lastname: Bollar
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Núñez
mesh_terms: D000293:Adolescent; D000328:Adult; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D002675:Child, Preschool; D004868:Equipment Failure; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000601:surgery*; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000134:cerebrospinal fluid; D000860:Hypoxia / Q000134:cerebrospinal fluid*; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000134:cerebrospinal fluid*; D011687:Purines / Q000134:cerebrospinal fluid*; D019820:Xanthine; D014970:Xanthines / Q000134:cerebrospinal fluid
chemical_list: D007042:Hypoxanthines; D011687:Purines; D014970:Xanthines; D019820:Xanthine; D019271:Hypoxanthine