Localization of dipole by boundary element method in three dimensional reconstructed monkey brain.
The boundary element method was applied to 3-dimensionally reconstructed monkey brain to localize a current source generator (dipole) of somatosensory evoked potentials (SEPs) recorded from epidural electrodes under assumption that a brain is electrically homogeneous and is bounded by a high resistant substance (skull). Absolute mean deviation of estimated dipoles from actual dipoles artificially generated by electrical stimulation at known coordinates in the brain were within 1-3 mm. The estimated dipole computed from SEPs by right median nerve stimulation at latency of P10-N10 waves was located in area 3b of the somatosensory hand area in monkey. Our data suggest that this technique of locating dipoles by the boundary element method applied to a reconstructed brain allows accurate determination of the 3-dimensional coordinates of a dipole.
Nishijo
H
H
Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Hayashi
N
N
Fukuda
M
M
Endo
S
S
Musha
T
T
Ono
T
T
D000465:Algorithms; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D008251:Macaca; D008954:Models, Biological; D014057:Tomography, X-Ray Computed