Prognostic value of a novel circulating serum 90K antigen in HIV-infected haemophilia patients.
We evaluated the prognostic role of a novel tumour-associated antigen, termed 90K, in a cohort of HIV+ asymptomatic haemophilia patients with known duration of seropositivity and median follow-up of about 7 years. The circulating levels of 90K are higher in HIV+ asymptomatic patients than HIV- controls. The antigen levels remain quite stable over time in non-progressing patients, while they steadily rise in patients evolving to ARC/AIDS. Baseline high 90K levels are predictive of faster progression to ARC/AIDS and shorter survival. We conclude that an elevated 90K serum level is a predictor of poor prognosis in HIV+ asymptomatic haemophiliacs.
Longo
G
G
Chair of Medical Oncology, University 'G. D'Annunzio', Chieti, Italy.
Natoli
C
C
Rafanelli
D
D
Tinari
N
N
Morfini
M
M
Rossi-Ferrini
P
P
D'Ostilio
N
N
Iacobelli
S
S
D000386:AIDS-Related Complex / Q000097:blood; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006023:Glycoproteins; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008074:Lipoproteins; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D011379:Prognosis; D016326:Extracellular Matrix Proteins
D000951:Antigens, Neoplasm; D015415:Biomarkers; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D006023:Glycoproteins; D008074:Lipoproteins; D009363:Neoplasm Proteins; C081856:LGALS3BP protein, human; D016326:Extracellular Matrix Proteins