Tissue-specific modulation of insulin receptor mRNA levels in a patient with a phaeochromocytoma.
We have observed that the expression of the insulin-receptor gene is regulated in a tissue-specific manner in a patient with a phaeochromocytoma. Our results indicate that insulin receptor mRNA levels are decreased in adipose tissue and increased in both liver and skeletal muscle as compared with the corresponding values in the same tissues of a control patient. These findings provide the first evidence that insulin receptor mRNA levels may be modulated in vivo by high levels of catecholamines.
Leal
M A
MA
Departamento de Bioquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Aller
P
P
Torres
A
A
Picardo
A
A
Calle
C
C
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D001345:Autoradiography; D015152:Blotting, Northern; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010673:Pheochromocytoma / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D011972:Receptor, Insulin / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D011972:Receptor, Insulin