Concentric membranous bodies and giant mitochondria in hepatocytes from a patient with AIDS.
The cytoplasm of hepatocytes in a liver biopsy from a patient with acquired immunodeficiency syndrome (AIDS) treated with sulfamethazole-trimethoprim contained concentric membranous bodies (CMB) and giant mitochondria. By light microscopy the general architecture of the liver was unaltered. By electron microscopy one to three CMB were present in random distribution within several cells in equal periportal and centrilobular localization. CMB were irregularly rounded or ovoid, loosely ribosome-studded lamellar whorls. Some were agranular or in parallel arrangement. Giant mitochondria often with paracrystalline inclusions were frequently in close association with CMB. Tubuloreticular inclusions were noted in Kupffer cell cytoplasm. Since CMB have been infrequently observed in human hepatocytes, are rare in nonneoplastic human liver, and have not been previously reported in association with AIDS, their appearance may relate to regenerative changes and/or sulfamethazole-trimethoprim therapy.
Shapiro
S H
SH
Queens Hospital Center, Department of Laboratories, Jamaica, New York 11432.
Klavins
J V
JV
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D000328:Adult; D002462:Cell Membrane / Q000648:ultrastructure; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology*; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure*; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects / Q000627:therapeutic use
D015662:Trimethoprim, Sulfamethoxazole Drug Combination