Long-term exposure to SMS 201-995 inhibits proliferation and calcitonin release in neoplastic C-cells.
The effect of the long-acting somatostatin analogue SMS 201-995 on cellular proliferation and calcitonin production was examined in rMTC 6-23 cells. A dose-dependent inhibition of calcitonin release and cellular calcitonin content was obtained in cells exposed to SMS 201-995 for 72 hrs. The dose-dependent antiproliferative effect of SMS 201-995 (10(-8)-10(-6) M) was significant after 72 hrs of exposure. SMS 201-995 has an inhibitory effect on calcitonin secretion and synthesis as well as on the growth of C-cells.
Mekonnen
Y
Y
Department of Biology, Faculty of Science, Addis Abeba University, Ethiopia.
Raue
F
F
Zink
A
A
Ziegler
R
R
D000818:Animals; D002116:Calcitonin / Q000378:metabolism*; D018276:Carcinoma, Medullary / Q000473:pathology / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015282:Octreotide / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013964:Thyroid Neoplasms / Q000473:pathology / Q000503:physiopathology*; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D002116:Calcitonin; D015282:Octreotide