Relationship between the level of c-myc mRNA and histologic aggressiveness in thyroid tumors.
We investigated the relationship between the level of c-myc mRNA and histologic aggressiveness in thyroid tumors obtained at surgery. In thyroid carcinomas, there was a positive correlation between these two parameters, while in benign tumors there was no correlation between cellularity and the expression of the proto-oncogene c-myc. These results might be useful in the prognosis of thyroid tumors and consequently helpful in the management of the patient.
Romano
M I
MI
Department of Endocrinology, Fundación CIMAE, Hospital Israelita Ezrah, Buenos Aires, Argentina.
Grattone
M
M
Karner
M P
MP
Moiguer
S
S
Tetelbaum
F
F
Romano
L A
LA
Illescas
E
E
Padin
R
R
Cueva
F
F
Burdman
J A
JA
D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology; D018265:Carcinoma, Papillary, Follicular / Q000235:genetics / Q000473:pathology; D016259:Genes, myc; D006801:Humans; D009361:Neoplasm Invasiveness; D009693:Nucleic Acid Hybridization; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger