[In vitro studies of possible transmission of human immunodeficiency virus (HIV) by allogeneic cartilage transplants].
With the increasing prevalence of the human immunodeficiency virus (HIV), the possibility of a transmission of HIV via allogenic transplants has increased. To assess the risk of transferring HIV with allogenic cartilage grafts we investigated the susceptibility of chondrocytes to the virus. Our results indicate the absence of the HIV receptor (CD-4-molecule) on chondrocytes by immunohistochemistry and FACS analyses. Furthermore cultures from chondrocytes and high doses of HIV-1 did not show an active replication. Hence, we conclude that normal cartilage cells cannot be infected by HIV. This means that the risk of HIV transmission by cartilage allografts is very low if no contaminating tissues like blood, perichondrium and calcifications etc. are present.
Bujía
J
J
HNO-Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Meyer
H
H
Kim
C
C
Hammer
C
C
Wilmes
E
E
Gürtler
L
L
D015704:CD4 Antigens / Q000032:analysis; D002356:Cartilage / Q000382:microbiology / Q000637:transplantation*; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D015658:HIV Infections / Q000382:microbiology / Q000635:transmission*; D006801:Humans; D007124:Immunoenzyme Techniques; D010038:Otorhinolaryngologic Diseases / Q000601:surgery*; D012225:Rhinoplasty; D014184:Transplantation, Homologous
D015704:CD4 Antigens
In-vitro-Untersuchungen zur möglichen Ubertragung des humanen Immundefizienz Virus (HIV) durch allogene Knorpeltransplantate.