Photodistributed nifedipine-induced facial telangiectasia.
Five months after starting nifedipine (Adalat), two patients developed photodistributed facial telangiectasia, which became more noticeable with time. Neither patient complained of photosensitivity or flushing. Both patients reported a significant cosmetic improvement after discontinuing the drug. One commenced the closely related drug amlodipine 3 years later, with recurrence of telangiectasia. The photodistribution of the telangiectasia suggests a significant drug/light interaction.
Collins
P
P
Department of Dermatology, Ninewells Hospital and Medical School, Dundee, U.K.
Ferguson
J
J
D000328:Adult; D017311:Amlodipine / Q000009:adverse effects; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology; D013684:Telangiectasis / Q000139:chemically induced* / Q000473:pathology
D017311:Amlodipine; D009543:Nifedipine