Effects of acute buprenorphine on responses to intranasal cocaine: a pilot study.
Five inpatients dependent on both intravenous cocaine and heroin were detoxified from opiates. They were then given 5 days of double-blind treatment with active or placebo buprenorphine 2 mg/d sublingually, followed by a crossover to the converse for 5 days (buprenorphine or placebo). Intranasal cocaine challenges (2 mg/kg) were performed on Days 3 and 5 of each treatment. Buprenorphine significantly enhanced patients' ratings of cocaine-induced pleasurable effects, and augmented cocaine-induced pulse increases. The buprenorphine enhancement of subjective cocaine effects appeared to be more prominent on Day 3 than on Day 5. This reduction from Day 3 to Day 5 suggests that cocaine may interact differently with buprenorphine as treatment is more prolonged.
Rosen
M I
MI
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Pearsall
H R
HR
McDougle
C J
CJ
Price
L H
LH
Woods
S W
SW
Kosten
T R
TR
D000328:Adult; D000339:Affect / Q000187:drug effects; D001143:Arousal / Q000187:drug effects*; D002047:Buprenorphine / Q000627:therapeutic use*; D003042:Cocaine / Q000009:adverse effects; D015897:Comorbidity; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005059:Euphoria / Q000187:drug effects; D005260:Female; D006556:Heroin Dependence / Q000523:psychology / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D013375:Substance Withdrawal Syndrome / Q000523:psychology; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
D002047:Buprenorphine; D003042:Cocaine