The amygdaloid complex, corticotropin releasing factor and stress-induced gastric ulcerogenesis in rats.
The amygdaloid complex and corticotropin releasing factor (CRF) are both important in stress reactions and we thus evaluated the effects of intra-amygdalar CRF on stress ulceration in rats. Bilateral micro-applications of CRF (0.05, 0.5 or 5.0 micrograms) into the central amygdala (CEA) attenuated cold restraint-induced gastric mucosal lesions in a dose-related manner. Similar gastric cytoprotective effects were seen with intra-CEA noradrenaline (NA; 3.0 micrograms), whereas the NA neurotoxin, DSP-4 (25 micrograms), or the beta-adrenoceptor antagonist, propranolol (1 microgram), aggravated stress ulcer pathology. Intra-CEA pretreatment with DSP-4 or propranolol clearly reversed the ulceroprotective effects of CRF during stress. These results indicate that the CEA is a neural substrate for CRF effects, and CRF-NA interactions in this limbic area are crucial for the regulation of stress ulcerogenesis.
Ray
A
A
Department of Pharmacology, University College of Medical Sciences, Delhi, India.
Henke
P G
PG
Gulati
K
K
Sen
P
P
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008845:Microinjections; D009498:Neurotoxins / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000209:etiology* / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D001596:Benzylamines; D009498:Neurotoxins; D003346:Corticotropin-Releasing Hormone; D011433:Propranolol; C012102:DSP 4; D009638:Norepinephrine