Reinduction of remission of chronic myeloid leukemia by donor leukocyte transfusion following relapse after bone marrow transplantation: recovery complicated by initial pancytopenia and late dermatomyositis.
A significant proportion of patients relapse after allogeneic BMT for CML. These relapses have been treated by induction of a graft-versus-leukemia effect by transfusing donor leukocytes. We have treated a 27-year-old woman with interferon and donor leukocyte transfusion and a complete haematological and cytogenetic remission was obtained coincident with the onset of GVHD. Her course was complicated by prolonged and profound pancytopenia which was fully reversed by the administration of rGM-CSF. She remains in CR with mild dermatomyositis due to chronic GVHD 17 months after the procedure.
Leber
B
B
Department of Medicine, McMaster University, Hamilton, Canada.
Walker
I R
IR
Rodriguez
A
A
McBride
J A
JA
Carter
R
R
Brain
M C
MC
D000328:Adult; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003882:Dermatomyositis / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D017708:Leukocyte Transfusion; D010198:Pancytopenia / Q000209:etiology* / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction; D016879:Salvage Therapy
D007155:Immunologic Factors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006918:Hydroxyurea