Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles.
The formation of constitutive secretory vesicles and secretory granules from the trans-Golgi network is inhibited by brefeldin A, suggesting a role for ADP ribosylation factor and other coat proteins in the budding process, and is regulated by multiple heterotrimeric G proteins. Membrane proteins are sorted to secretory granules through signals in their cytoplasmic domains and, like secretory proteins, by aggregation of their lumenal domains. Synaptic vesicle membrane proteins undergo exocytotic-endocytotic recycling before synapse formation, consistent with the proposed biogenesis of synaptic vesicles from early endosomes.
Bauerfeind
R
R
University of Heidelberg, Germany.
Huttner
W B
WB
D001704:Biopolymers; D020126:Brefeldin A; D003517:Cyclopentanes / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology; D008565:Membrane Proteins / Q000032:analysis; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011506:Proteins / Q000502:physiology; D013572:Synaptic Vesicles / Q000187:drug effects / Q000502:physiology*
D001704:Biopolymers; D003517:Cyclopentanes; D008565:Membrane Proteins; D011500:Protein Synthesis Inhibitors; D011506:Proteins; D020126:Brefeldin A; D019204:GTP-Binding Proteins