A skin irritant principle from Euphorbia matabelensis Pax.
A diterpene of the ingenane-type parent alcohol with tetradecanoic acid as the acid substituent was isolated by chromatographic methods from the latex of Euphorbia matabelensis. The ingenol ester exhibited irritant activity on the mouse ear.
Gundidza
M
M
Department of Pharmacy, Faculty of Medicine, University of Zimbabwe, Harare.
Sorg
B
B
Hecker
E
E
D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology; D004431:Ear, External / Q000187:drug effects; D007509:Irritants / Q000302:isolation & purification / Q000633:toxicity*; D007840:Latex / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010947:Plants, Toxic / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D004224:Diterpenes; D007509:Irritants; D007840:Latex; C008125:ingenol