HLA-A and -B antigens in chronic bronchitis.
The A- and B- types of Human Leucocyte Antigens (HLA) were examined in a group of Greek patients with a diagnosis of chronic bronchitis. The results were compared to those of 400 healthy unrelated controls (smokers and non-smokers) from the same population. A statistically significant increase of HLA-A1 and HLA-B17 was noted; a similar increase was also noted when only healthy smokers were utilized as a control group. These results support the hypothesis that genetic factors are also involved in the pathogenesis of this common disease.
Anagnostopoulou
U
U
Athens Chest Diseases Hospital, Greece.
Toumbis
M
M
Konstantopoulos
K
K
Kotsovoulou-Fouskaki
V
V
Zervas
J
J
D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000235:genetics / Q000276:immunology*; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000276:immunology
D015234:HLA-A Antigens; D015235:HLA-B Antigens