Prophylactic effects of pirenzepine (M1-blocker) on intraoperative stress ulcer: comparison with an H2-blocker.
Patients under general anesthesia were treated with either an H2-blocker, ranitidine 50 mg, or an M1-blocker, pirenzepine 10 mg, and the effects of the two drugs on the gastric mucosa were compared by the measurement of the gastric juice pH and viscosity. The results showed that pirenzepine increased the gastric juice pH sufficiently while maintaining the gastric juice viscosity, and that ranitidine maintained the gastric juice pH higher than pirenzepine while decreasing the gastric juice viscosity. These results suggest that treatment with pirenzepine may have advantages in the prevention of stress ulcers.
Takakura
K
K
Department of Anesthesiology and Reanimatology, Fukui Medical School, Japan.
Harada
J
J
Mizogami
M
M
Goto
Y
Y
D000328:Adult; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007430:Intraoperative Care; D007431:Intraoperative Complications / Q000517:prevention & control*; D008875:Middle Aged; D018727:Muscarinic Antagonists; D010890:Pirenzepine / Q000627:therapeutic use*; D011899:Ranitidine / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications* / Q000209:etiology; D014783:Viscosity
D018727:Muscarinic Antagonists; D010890:Pirenzepine; D011899:Ranitidine