title: Mineralizing pulmonary elastosis in chronic cardiac failure. "Endogenous pneumoconiosis" revisited.
abstract: The histopathology, ultrastructure, and clinicopathologic correlations in six patients with cardiac failure and iron encrustation of lung elastic tissue were examined at autopsy. Transmission electron microscopy (TEM) and energy dispersive x-ray analysis were applied to two cases. Of the group, five patients had cardiac failure due to systemic hypertension (4 patients), valvular disease (4 patients), or coronary atherosclerosis (4 patients). Biventricular failure in one patient was associated with sleep apnea. Both iron and calcium, identified by histochemical stains, impregnated degenerated alveolar and vascular elastic fibers and were associated with a foreign body reaction and focal interstitial fibrosis. Energy dispersive x-ray analysis and TEM demonstrated iron and calcium on the microfibrillar portion of elastin. Morphometry indicated vascular changes of pulmonary venous hypertension. The authors concluded that mineral deposition probably represents nonspecific precipitation of metallic ions on altered elastic fibers in patients with cardiac failure. "Mineralizing elastosis" potentially contributes to lung restriction and, occasionally, can be a source of diagnostic confusion.
authors.affiliation: Department of Pathology, Metrohealth Medical Center, Cleveland, OH 44109-1988.
authors.forename: U
authors.initials: U
authors.lastname: Pai
authors.forename: J
authors.initials: J
authors.lastname: McMahon
authors.forename: J F
authors.initials: JF
authors.lastname: Tomashefski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002130:Calcium Phosphates / Q000032:analysis; D004547:Elastic Tissue / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007501:Iron / Q000032:analysis*; D008168:Lung / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009929:Organ Size
chemical_list: D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D007501:Iron; C485829:calcium phosphate, dibasic, anhydrous