title: Interactive multivariate analysis of bisindolylmaleimides as potent protein kinase C antagonists.
abstract: The isoenzyme protein kinase C (PKC) inhibitory activity of substituted bisindolylmaleimides depends on the molecular weight, the total charge, and dipole moments. The validity of the resulting QSAR equation was investigated by interactive diagnostic statistics and multivariate simultaneous statistical inference. Molecular mechanics and dynamics can be used to study possible reasons of flagged observations (high-leverage points, influential data, outliers) of QSAR systems.
authors.affiliation: Institute of Pharmacology and Toxicology, University of Leipzig, Germany.
authors.forename: P P
authors.initials: PP
authors.lastname: Mager
mesh_terms: D008301:Maleimides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D015999:Multivariate Analysis; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D008301:Maleimides; D011493:Protein Kinase C