Human leucocyte antigen DNA typing in Singaporean Chinese patients with Graves' disease.
Human Leucocyte Antigen (HLA) A, B, C, DR, DQ and DP locus alleles in 35 Chinese patients with Graves' disease and 80 controls were typed for using serological and DNA polymerase chain reaction/sequence specific oligonucleotide (PCR/SSO) methods. B46 was found to be strongly associated with male patients (p = 0.0002; RR = 8.2, 95% confidence interval 2.1-32.2). In HLA class 1 alleles, besides B46, the frequencies of A2 and Cw1 were increased and A24 and B63 decreased in patients compared to controls. In HLA class 2 alleles, the frequencies of DRB1*1602, *0301, *1405, DRB5*02, DQB1*0502 were increased and DRB1*1501, DQB1*0301 decreased in patients.
Chan
S H
SH
Department of Microbiology & WHO Immunology Centre, Faculty of Medicine, National University of Singapore.
Lin
Y N
YN
Wee
G B
GB
Ren
E C
EC
Lui
K F
KF
Cheah
J S
JS
D000328:Adult; D000483:Alleles; D002681:China / Q000208:ethnology; D003431:Cross-Cultural Comparison; D004247:DNA / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006111:Graves Disease / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012846:Singapore
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D004247:DNA