[Occupational exposure to isocyanates and individual susceptibility].
Patients with organic diisocyanate-induced pulmonary disease may be specially susceptible to the toxic effects of agent. Among 11 cases diagnosed in one year, the majority (10/11) were slow acetylators. The same patients were different from the control population in terms of alpha-1-antitrypsin phenotypes. Heterozygous combinations were more frequent than among controls. It seems that the combination of low N-acetylation capacity and a heterozygous alpha-1-antitrypsin predisposes to the disease.
Berode
M
M
Institut universitaire de médecine et d'hygiène du travail (IUMHT), Lausanne.
Savolainen
H
H
D000107:Acetylation; D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D001711:Biotransformation; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D017953:Isocyanates / Q000378:metabolism / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000209:etiology*; D000515:alpha 1-Antitrypsin / Q000235:genetics
D017953:Isocyanates; D000515:alpha 1-Antitrypsin
Exposition professionnelle aux isocyanates et susceptibilité individuelle.