[The costimulating effect of chorionic gonadotropin on lymphokine-activated splenocytes. A new aspect of the immunomodulating action of the pregnancy hormone].
An immunodepressive effect of chorionic gonadotropin (CG) low (40IU) and high (200IU) doses on the processes of lymphocyte antigen-independent differentiation, realizing the primary immune response has been established in the short-term culture of mice splenic intact cells. Splenocyte activation by Con-A or human recombinant IL-2 does not show an expressive immunostimulating effect on the processes of plaque forming cells (PFC) formation. While the immunomodulating effect of CG on the background of these activators changes. In the presence of Con-A or IL-2, hormone in the dose of 40 IU can't effectively suppress the PFC formation processes. On the background of IL-2, CG-200IU shows an expressed opposite effect, increasing the splenocyte ability to form PFC twice as much. It is suggested, that CG appears to be a cofactor, intensifying the processes of immunocompetent cell proliferation and differentiation, connected with this lymphokine. A new aspect of the CG immunomodulating effect during pregnancy is being discussed now.
Shirshev
S V
SV
Kevorkov
N N
NN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000494:pharmacology; D008222:Lymphokines / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D013268:Stimulation, Chemical
D000276:Adjuvants, Immunologic; D006063:Chorionic Gonadotropin; D007376:Interleukin-2; D008222:Lymphokines; D003208:Concanavalin A
Kostimuliruiushchiĭ éffekt khorionicheskogo gonadotropina na limfokinaktivirovannye splenotsity. Novyĭ aspekt immunomoduliruiushchego deĭstviia gormona beremennosti.