Tumour induction by transplacental infection with polyoma virus of the F1 generation of Wistar rats.
Intravenous polyoma virus inoculation into pregnant Wistar rats resulted in transplacental infection of the foetus, causing tumours and hydronephroses. Cyclosporin A reduced these effects significantly.
Verhagen
W
W
Institute of Virology, Medical School of Hannover, Federal Republic of Germany.
Hubert
C M
CM
Mohtaschem
E
E
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D001739:BK Virus / Q000276:immunology / Q000472:pathogenicity*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006391:Hemangioma / Q000209:etiology; D006869:Hydronephrosis / Q000209:etiology; D007165:Immunosuppression Therapy; D007680:Kidney Neoplasms / Q000209:etiology; D009423:Nervous System Neoplasms / Q000209:etiology; D030361:Papillomavirus Infections / Q000276:immunology / Q000635:transmission*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012513:Sarcoma, Experimental / Q000209:etiology; D014412:Tumor Virus Infections / Q000276:immunology / Q000635:transmission*
D000914:Antibodies, Viral; D016572:Cyclosporine