A reappraisal of steroid-induced osteoporosis.
The anti-inflammatory and immunosuppressive effects of corticosteroids were first recognized by Hench and colleagues in 1949. It soon became apparent that supraphysiological doses were associated with numerous side effects, particularly osteoporosis and skeletal failure. In spite of this, the pathogenesis of steroid osteoporosis remains unclear and its prevention and treatment controversial.
Jenkinson
T
T
Royal National Hospital for Rheumatic Diseases, Bath.
Bhalla
A K
AK
D000293:Adolescent; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control
D005938:Glucocorticoids