Antifungal metabolites from Trichoderma harzianum.
A detailed examination of the metabolites produced in liquid cultures by a strain of Trichoderma harzianum, isolated from wheat roots, has resulted in the identification of a further five metabolites. Two of these, cyclonerodiol [5] and the octaketide keto diol 6, have previously been isolated from a strain of Trichoderma koningii. The structures of the three new octaketide-derived compounds 7, 8, and 10 have been deduced from spectroscopic and chemical studies. All newly isolated compounds show antibiotic activity towards the take-all fungus, Gaeumannomyces graminis var. tritici.
Ghisalberti
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Department of Chemistry, University of Western Australia, Nedlands.
Rowland
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D000107:Acetylation; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D002853:Chromatography, Liquid; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D014242:Trichoderma / Q000737:chemistry / Q000378:metabolism*
D000935:Antifungal Agents