[Effects of ulinastatin on rat renal energy metabolism around ischemia studied by 31P MRS].
The effects of ulinastatin (UTI) on rat renal energy metabolism during ischemia and reperfusion were studied by 31P nuclear magnetic resonance spectroscopy (31P MRS) in vivo. Rat kidney was exposed to ischemia for 30 min by clamping the abdominal aorta above the renal arteries. Pre-ischemic administration of UTI inhibited the decline of intracellular pH (pHi) during ischemia and improved the recovery of renal energy metabolism and pHi after reperfusion. This result suggests that UTI might inhibit anaerobic metabolism during renal ischemia and an improve energy metabolism during reperfusion. 31P MRS provided a unique tool to study intact cellular function continuously in noninvasive fashion, allowing assessment of metabolic function during ischemia and after reperfusion.
Ueki
M
M
Department of Anesthesiology and Emergency Medicine, Kagawa Medical School, Kagawa.
Yokono
S
S
Taie
S
S
Ogli
K
K
D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D006023:Glycoproteins / Q000494:pharmacology*; D007511:Ischemia / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010758:Phosphorus; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion
D006023:Glycoproteins; D010758:Phosphorus; C028665:urinastatin