title: Significance of epidermal growth factor receptor expression in primary human endometrial cancer.
abstract: Radioreceptorial assessment of EGFR expression was prospectively performed on 60 primary human endometrial tumors. Of these, 26 were EGFR-positive while 13 expressed high EGFR levels. High EGFR levels correlated well with poor histopathological grading. No correlation with histopathological type, stage, myometrial invasion, lymph-node involvement or steroid hormone receptor status was observed. Disease-free survival rate was significantly shorter in the cases with high than in the cases with low EGFR levels. These results suggest a potential role of EGFR expression assessment in prognostic characterization of endometrial cancer patients.
authors.affiliation: Department of Gynecology/Obstetrics, Catholic University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Scambia
authors.forename: P
authors.initials: P
authors.lastname: Benedetti Panici
authors.forename: G
authors.initials: G
authors.lastname: Ferrandina
authors.forename: F
authors.initials: F
authors.lastname: Battaglia
authors.forename: M
authors.initials: M
authors.lastname: Distefano
authors.forename: G
authors.initials: G
authors.lastname: D'Andrea
authors.forename: R
authors.initials: R
authors.lastname: De Vincenzo
authors.forename: F
authors.initials: F
authors.lastname: Maneschi
authors.forename: F O
authors.initials: FO
authors.lastname: Ranelletti
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015993:Life Tables; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011869:Radioligand Assay; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D016019:Survival Analysis
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D066246:ErbB Receptors