[DNA replication in intact and X-ray-irradiated cells in the Cockayne syndrome].
Using DNA fiber autoradiography, an estimation was made of DNA replication in normal fibroblasts and in those derived from a patient with Cockayne syndrome. The rate of replication fork movement as well as the rate of DNA chain growth, dependent on the frequency of initiation sites in the adjacent clusters of replicons, did not differ in Cockayne syndrome cells, compared to cells of normal donors, either before or after exposure to ionizing radiation.
Nergadze
S G
SG
Pleskach
N M
NM
Mikhel'son
V M
VM
Prokof'eva
V V
VV
Barenfel'd
L S
LS
D001345:Autoradiography; D002478:Cells, Cultured / Q000378:metabolism / Q000528:radiation effects; D003057:Cockayne Syndrome / Q000378:metabolism*; D004261:DNA Replication / Q000528:radiation effects*; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D008297:Male; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D013936:Thymidine
Replikatsiia DNK v intaktnykh i obluchennykh X-luchami kletkakh pri sindrome Kokeĭna.