Animal models of BCR/ABL-induced leukemias.
Chronic myelogenous leukemia (CML) serves as a valuable paradigm for understanding the molecular genetic origins of cancer. The cytogenetic standard of diagnosis, the Philadelphia chromosome, has been superseded by a molecular definition for the disease, that of BCR/ABL gene rearrangement. The use of BCR/ABL to recreate CML in mice fulfills Koch's postulates for molecular pathogenesis. The present murine systems facilitate research into the biology of BCR/ABL-induced leukemias, but fall short in their promise to provide models for testing new therapies for CML. A transgenic strain of mice with an inheritable predisposition to CML would be an invaluable tool.
Daley
G Q
GQ
Department of Medicine, Massachusetts General Hospital, Boston 02114.
D000818:Animals; D001752:Blast Crisis / Q000235:genetics; D004195:Disease Models, Animal; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000502:physiology*; D015973:Gene Expression Regulation, Leukemic; D016313:Genes, abl; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D051379:Mice; D008822:Mice, Transgenic; D013045:Species Specificity
D016044:Fusion Proteins, bcr-abl