title: Time course of the changes in prednisolone pharmacokinetics after co-administration or discontinuation of rifampin.
abstract: We have investigated changes in the pharmacokinetics of prednisolone caused by co-administration or discontinuation of rifampin. Serial IV pharmacokinetic studies of prednisolone (1 mg/kg) in groups of 3 patients over a 1 month period of rifampin co-treatment or after its withdrawal, revealed significant changes in the area under the curve, the total clearance, the non-renal clearance and the half-life. The changes in the pharmacokinetic parameters reached a 1.5 to 2-fold plateau after 2 weeks and the half maximal effect was attained within 5 days. Neither the volume of distribution nor the protein binding of prednisolone were significantly altered.
authors.affiliation: Department of Pharmacology, Clinical Pharmacology, Seoul National University College of Medicine, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: J G
authors.initials: JG
authors.lastname: Shin
authors.forename: W S
authors.initials: WS
authors.lastname: Chong
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: I J
authors.initials: IJ
authors.lastname: Jang
authors.forename: S G
authors.initials: SG
authors.lastname: Shin
mesh_terms: D000328:Adult; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000378:metabolism; D011239:Prednisolone / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D011485:Protein Binding; D012293:Rifampin / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D011239:Prednisolone; D012293:Rifampin