title: A study on withdrawal related haemodynamic response in chronic propranolol treated conscious rats.
abstract: Single dose of propranolol hydrochloride (5 mg/kg, i.p.) caused significant fall in heart rate (HR) but not in systolic blood pressure (SBP) in normotensive conscious rats. Multiple doses of propranolol (5 mg/kg, i.p., twice-a-day for 5 wk) caused significant fall in both HR and SBP at 2 wk and 4 wk in normotensive conscious rats. Sudden withdrawal of propranolol at 5 wk caused a significant blood pressure upswing and tachycardia between 12-24 h followed by normalization of both blood pressure and heart rate. The study documents a possible model of rebound hypertension in normotensive conscious rats.
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
authors.forename: A
authors.initials: A
authors.lastname: Chakrabarti
authors.forename: P L
authors.initials: PL
authors.lastname: Sharma
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D011433:Propranolol / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013610:Tachycardia / Q000139:chemically induced*
chemical_list: D011433:Propranolol