Soluble CD4, CD8 in patients with polymyositis/dermatomyositis.
The concentrations of soluble CD4 (sCD4) and soluble CD8 (sCD8) were determined in 64 patients with polymyositis/dermatomyositis (PM/MD). The patients with PM/DM had significantly higher concentrations of sCD8, though the concentrations of sCD4 did not significantly increase. Patients with high concentrations of sCD8 tended to have too high concentrations of soluble interleukin-2 receptor (sIL-2R). The patients with high levels of myogenic enzymes tended to have high concentrations of sCD8. The results of a serial study indicated that the concentrations of sCD8 decreased simultaneously with the decrease of the myogenic enzymes. These results may suggest that the activation of CD8+ cells are related to muscular involvement.
Tokano
Y
Y
Department of Internal Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
Obara
T
T
Hashimoto
H
H
Okumura
K
K
Hirose
S
S
D000328:Adult; D000368:Aged; D015704:CD4 Antigens / Q000032:analysis*; D016827:CD8 Antigens / Q000032:analysis*; D003882:Dermatomyositis / Q000201:enzymology / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D017285:Polymyositis / Q000201:enzymology / Q000276:immunology* / Q000503:physiopathology; D012995:Solubility
D015704:CD4 Antigens; D016827:CD8 Antigens