D-penicillamine and polymyositis: the significance of the anti-Jo-1 antibody.
A 57-yr-old lady developed polymyositis whilst taking D-penicillamine for RA. D-Penicillamine-induced polymyositis occurs in RA with a greater frequency than idiopathic polymyositis. Anti-acetyl choline receptor antibodies and ANA were positive, consistent with drug-induced disease. Anti-Jo-1 antibodies are considered specific for idiopathic myositis, and their presence was unexpected. Following withdrawal of the drug, the disappearance of the anti-Jo-1 and other antibodies coincident with clinical improvement, suggested that D-penicillamine was responsible for inducing antibody production.
Jenkins
E A
EA
Department of Rheumatology, Queen Alexandra Hospital, Cosham, Portsmouth.
Hull
R G
RG
Thomas
A L
AL
D000906:Antibodies / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D017285:Polymyositis / Q000139:chemically induced* / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody; D011950:Receptors, Cholinergic; D010396:Penicillamine