A cytotoxic beta-carboline from the bryozoan Catenicella cribraria.
1-Vinyl-8-hydroxy-beta-carboline was identified as the cytotoxic constituent of the bryozoans Catenicella cribraria and Cribricellina cribraria. Literature nmr data for this previously known compound, now reported from a new source, were corrected.
Beutler
J A
JA
Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, Maryland 21702-1201.
Cardellina
J H
JH
Prather
T
T
Shoemaker
R H
RH
Boyd
M R
MR
Snader
K M
KM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002013:Bryozoa / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014753:Vinyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002243:Carbolines; D014753:Vinyl Compounds; C085149:1-vinyl-8-hydroxy-beta-carboline