Studies on the synthesis and antidepressant activity of some 1-thiocarbamoyl-3,5-diphenyl-2-pyrazolines.
Several 1-thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives have been synthesized by reacting 1,3-diphenyl-2-propen-1-one (chalcones) with thiosemicarbazide, or hydrazine hydrate and then with various isothiocyanates. Their chemical structures have been proven by UV, IR, 1H-NMR and elemental analysis. Antidepressant activities were investigated by "Porsolt's Behavioural Despair Test". 1-Thiocarbamoyl-3-(phenyl and 4-chlorophenyl-5-(4-methyl and 4-methoxyphenyl-2-pyrazoline (compounds III, IV, VII, VIII) and 3-(4-methylphenyl)-5-(4-methoxyphenyl)-2-pyrazoline (compound XII) showed equivalent or higher activity than pargyline hydrochloride and tranylcypromine sulfate.
Bilgin
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AA
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Palaska
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E
Sunal
R
R
D000818:Animals; D000928:Antidepressive Agents / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010293:Pargyline / Q000494:pharmacology; D011720:Pyrazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013550:Swimming; D014191:Tranylcypromine / Q000494:pharmacology
D000928:Antidepressive Agents; D011720:Pyrazoles; D014191:Tranylcypromine; D010293:Pargyline