title: Correlation of circulating antibody and cellular immunity with resistance against Cryptosporidium baileyi in broiler chickens.
abstract: The correlation of circulating antibody and cell-mediated immunity (CMI) with resistance to Cryptosporidium baileyi was studied using hormonal and chemical bursectomy in the one experiment and cyclosporin A in a second experiment. In Expt. 1, there was no correlation between antibody (confirmed by enzyme-linked immunosorbent assay) and resistance to infection as measured by body weight, gross lesions, morbidity, and mortality. Bursectomy altered antibody production, but not CMI, as measured by the delayed-type hypersensitivity skin reaction. In Expt. 2, cyclosporin A reduced CMI, but not antibody production. Chicks treated with cyclosporin A were more susceptible to C. baileyi (more severe respiratory disease) than untreated controls. Results suggested that CMI is more important in resistance to C. baileyi than circulating antibody.
authors.affiliation: Department of Poultry Science, Auburn University, Alabama 36849-5416.
authors.forename: J
authors.initials: J
authors.lastname: Hatkin
authors.forename: J J
authors.initials: JJ
authors.lastname: Giambrone
authors.forename: B L
authors.initials: BL
authors.lastname: Blagburn
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan / Q000008:administration & dosage; D002060:Bursa of Fabricius / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D003457:Cryptosporidiosis / Q000209:etiology / Q000276:immunology; D003458:Cryptosporidium / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D011201:Poultry Diseases / Q000209:etiology / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan