Specific antibody levels in free-ranging rhesus monkeys: relationships to plasma hormones, cardiac parameters, and early behavior.
Levels of tetanus-specific antibodies were assessed in free-ranging, yearling rhesus monkeys following prophylactic immunization with tetanus toxoid. Each subject's behavior had been observed between 11 and 25 weeks of age and approximately 2 months later during its mother's first concentrated mating period as a part of another study. Prior to immunization, at approximately 1 year of age, cardiovascular parameters, and several plasma parameters [cortisol, adrenocorticotrophic hormone (ACTH), growth hormone (GH), interleukin-2 (IL-2), and total plasma immunoglobulin G (IgG)] were measured during a brief period of captivity. Antibody titers noted approximately 2 weeks after immunization were related to cardiovascular parameters. Thus, yearlings with high heart rates and low heart rate variability during captivity had the highest tetanus-specific serum IgG. Levels of plasma cortisol, ACTH, total IgG, and IL-2 noted at the time of capture were unrelated to subsequent antibody levels. Antibody titers were, however, positively correlated with GH noted immediately following capture on the day prior to immunization. Antibody titers were also related to the infants' behavior observed during their mother's first concentrated mating period. Infants who were most distressed (high levels of distress vocalization) when their mother resumed mating (a time particularly stressful for free-ranging rhesus infants) showed lower antibody titers to tetanus immunization as a yearling. The present observations add support to the existence of a relationship between behavior during exposure to an early stressor and later immune regulation and that certain cardiovascular parameters may be related to certain indicators of immunoregulation.
Laudenslager
M L
ML
University of Colorado Health Sciences Center, Department of Psychiatry, Denver 80220.
Rasmussen
K L
KL
Berman
C M
CM
Suomi
S J
SJ
Berger
C B
CB
D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000276:immunology; D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000276:immunology*; D001522:Behavior, Animal; D004562:Electrocardiography; D006854:Hydrocortisone / Q000097:blood* / Q000276:immunology; D007114:Immunization; D007376:Interleukin-2 / Q000097:blood* / Q000276:immunology; D008253:Macaca mulatta; D009206:Myocardium / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology
D000906:Antibodies; D007376:Interleukin-2; D013745:Tetanus Toxoid; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone