Vitamin E and alpha-lipoate: role in antioxidant recycling and activation of the NF-kappa B transcription factor.
Nuclear factor kappa B (NF-kappa B) is believed to play an important role in the activation of human immunodeficiency virus (HIV) which causes acquired immunodeficiency syndrome (AIDS). Recent findings suggesting an involvement of reactive oxygen species in signal transduction pathways leading to NF-kappa B activation have encouraged the possible clinical use of antioxidants in blocking HIV activation. We have examined the effects of vitamin E and alpha-lipoate derivatives on NF-kappa B activation, and have observed that each of these antioxidants behave differently. Here we propose mechanisms of antioxidant actions in influencing cell signalling for NF-kappa B activation.
Packer
L
L
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Suzuki
Y J
YJ
D000975:Antioxidants / Q000494:pharmacology*; D001483:Base Sequence; D001665:Binding Sites; D002460:Cell Line; D004247:DNA / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D006678:HIV / Q000187:drug effects / Q000502:physiology; D016325:HIV Long Terminal Repeat; D006801:Humans; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction; D008063:Thioctic Acid / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology*
D000975:Antioxidants; D016328:NF-kappa B; D014810:Vitamin E; D008063:Thioctic Acid; D004247:DNA