title: Validation of global and segmental left ventricular contractile function using gated planar technetium-99m sestamibi myocardial perfusion imaging.
abstract: OBJECTIVE
  The purpose of this study was to test the hypothesis that segmental wall motion analysis determined from gated planar technetium-99m sestamibi myocardial imaging is reproducible and agrees well with echocardiographic data.
  
  
  BACKGROUND
  Technetium-99m sestamibi is a new radiopharmaceutical recently approved for myocardial perfusion imaging. Its advantages include a dosimetry that allows use of a dose 10 to 15 times higher than that of thallium-201. As a result, myocardial counts are markedly improved and images can be collected in a gated mode to potentially allow assessment of global and segmental ventricular function. However, the reproducibility and accuracy of technetium-99m sestamibi imaging for measurement of global and segmental left ventricular function have not been evaluated or compared with those of a standard ventricular function technique, such as echocardiography.
  
  
  METHODS
  We studied 136 patients referred for clinical technetium-99m sestamibi imaging. One-day rest-stress planar technetium-99m sestamibi protocols were used, gating the stress images. After technetium-99m sestamibi imaging, all patients had standard rest two-dimensional echocardiography. Global and segmental technetium-99m sestamibi and echocardiographic left ventricular contraction was graded qualitatively as normal or abnormal using a four-point grading system.
  
  
  RESULTS
  Interobserver and intraobserver agreement was extremely high for global and segmental technetium-99m sestamibi wall motion analysis, with absolute agreements ranging from 0.92 to 1.00 and corresponding kappa values of 0.74 to 1.00 (p < 0.00001). Agreement with global and segmental echocardiographic wall motion was similarly very high, with absolute agreements ranging from 0.93 to 1.00 and corresponding kappa values of 0.75 to 1.00 (p < 0.00001).
  
  
  CONCLUSIONS
  Gated technetium-99m sestamibi cardiac imaging provides information with regard to rest global and segmental left ventricular systolic function that is highly reproducible and agrees very well with results of two-dimensional echocardiography.
authors.affiliation: Department of Medicine, University of Vermont, College of Medicine, Burlington 05401.
authors.forename: M D
authors.initials: MD
authors.lastname: Tischler
authors.forename: J B
authors.initials: JB
authors.lastname: Niggel
authors.forename: R W
authors.initials: RW
authors.lastname: Battle
authors.forename: J T
authors.initials: JT
authors.lastname: Fairbank
authors.forename: K A
authors.initials: KA
authors.lastname: Brown
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015588:Observer Variation; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi; D016277:Ventricular Function, Left
chemical_list: D017256:Technetium Tc 99m Sestamibi