Effects of growth hormone on the metabolism of lipids and water and their potential in causing adverse events during growth hormone treatment.
GH effects certain changes in the metabolism of lipids and body water in humans. The effects of GH, such as high blood pressure, an increase in cholesterol and triglycerides, and lipoatrophy, among others, must, however, be seen in the context of the diverse disorders being treated. The risks faced in acromegaly, for instance, are not necessarily shared by Turner's syndrome patients treated with GH. The various metabolic effects of GH could thus be said to lead to adverse events in certain risk groups, which makes the monitoring of relevant parameters essential during treatment with GH.
Ranke
M B
MB
University Children's Hospital, Tübingen, FRG.
D013006:Growth Hormone / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000097:blood*; D012307:Risk Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects
D008055:Lipids; D013006:Growth Hormone