Vaginal immunization of monkeys against urinary tract infection with a multi-strain vaccine.
Cynomolgus monkeys were treated with a vaccine containing 10 heat-killed uropathogenic bacteria including 6 Escherichia coli strains. The multi-strain vaccine was administered either as a vaginal surface immunogen or intramuscularly. Following an induced E. coli cystitis, bladder infections were significantly reduced compared with controls at 1 and 2 weeks (intramuscular route) or 1 week (vaginal route) after UTI. This vaccine has been shown to be efficacious against cystitis in humans when given parenterally and has now proved efficacious in nonhuman primates by the vaginal mucosal route.
Uehling
D T
DT
Department of Surgery (Urology), University of Wisconsin Medical School, Madison.
Hopkins
W J
WJ
James
L J
LJ
Balish
E
E
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D003556:Cystitis / Q000382:microbiology / Q000517:prevention & control*; D004927:Escherichia coli Infections / Q000517:prevention & control*; D005260:Female; D007114:Immunization / Q000379:methods*; D007136:Immunoglobulins / Q000096:biosynthesis; D008252:Macaca fascicularis; D014552:Urinary Tract Infections / Q000517:prevention & control*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014621:Vagina
D001428:Bacterial Vaccines; D007136:Immunoglobulins; D015164:Vaccines, Inactivated