title: Effect of magnetic susceptibility contrast medium on myocardial signal intensity with fast gradient-recalled echo and spin-echo MR imaging: initial experience in humans.
abstract: OBJECTIVE
  To show the effect of dysprosium diethylenetriaminepentaacetic acid bis-methylamine injection on the images of normal human myocardium.
  
  
  METHODS
  T2-sensitive fast gradient-recalled echo (GRE) (repetition time [TR], 10.8 msec; echo time [TE], 4.2 msec) and spin-echo (SE) (TR, three RR intervals; TE, 60 msec) magnetic resonance (MR) imaging with driven equilibrium-preparation pulse was used to produce T2 contrast material enhancement. The contrast agent was injected into 12 healthy subjects at doses of 0.05, 0.1, 0.2, 0.4, and 0.6 mmol/kg.
  
  
  RESULTS
  Driven equilibrium-prepared GRE images showed a transient decrease of myocardial signal intensity at doses of 0.2-0.6 mmol/kg. Postcontrast T2-weighted SE images showed a myocardial signal attenuation (30%-45% decrease) at a dose of 0.4 mmol/kg or higher.
  
  
  CONCLUSIONS
  Dynamic MR imaging with a magnetic susceptibility contrast medium can be used to monitor the first pass of contrast media through human myocardium with a conventional MR imager and a fast GRE sequence.
authors.affiliation: Department of Radiology, University of California, San Francisco 94343-0628.
authors.forename: H
authors.initials: H
authors.lastname: Sakuma
authors.forename: M
authors.initials: M
authors.lastname: O'Sullivan
authors.forename: J
authors.initials: J
authors.lastname: Lucas
authors.forename: M F
authors.initials: MF
authors.lastname: Wendland
authors.forename: M
authors.initials: M
authors.lastname: Saeed
authors.forename: M C
authors.initials: MC
authors.lastname: Dulce
authors.forename: A
authors.initials: A
authors.lastname: Watson
authors.forename: K L
authors.initials: KL
authors.lastname: Bleyl
authors.forename: N D
authors.initials: ND
authors.lastname: LaFrance
authors.forename: C B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D000328:Adult; D003287:Contrast Media; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid