title: Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. Part 1A. Prebreeding phase: clinical health findings.
abstract: A group of 80 menstruating rhesus (Macaca mulatta) monkeys, with an average estimated age of 11.1 +/- 4.1 yr SD, were first randomly allocated to four similar test rooms (20 monkeys/room) and then randomly allocated to one of the five dose groups (four females/dose group/room). Each day, the females self-ingested capsules containing doses of 0, 5, 20, 40 or 80 micrograms Aroclor 1254/kg body weight. After 25 months of daily dosing, approximately 90% of the treated females attained a qualitative pharmacokinetic steady state with respect to the concentration of polychlorinated biphenyl in their adipose tissue. The test monkeys were monitored daily for health and menstrual status, as well as feed and water consumption. On a weekly basis, each female's body weight was determined and a detailed clinical examination was conducted. Minor treatment effects included a slight, but not statistically significant, decrease in feed and water consumption as well as a decreased feed conversion ratio and a slight increase in the duration of menses. Statistically significant, dose-related treatment effects included inflammation and/or prominence of the tarsal (Meibomian) glands, eye exudate, and various finger and toe nail changes. These results were found at doses lower than those previously reported for non-human primates.
authors.affiliation: Toxicology Research Division, Health and Welfare Canada, Ottawa, Ontario.
authors.forename: D L
authors.initials: DL
authors.lastname: Arnold
authors.forename: F
authors.initials: F
authors.lastname: Bryce
authors.forename: R
authors.initials: R
authors.lastname: Stapley
authors.forename: P F
authors.initials: PF
authors.lastname: McGuire
authors.forename: D
authors.initials: D
authors.lastname: Burns
authors.forename: J R
authors.initials: JR
authors.lastname: Tanner
authors.forename: K
authors.initials: K
authors.lastname: Karpinski
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001140:Aroclors / Q000032:analysis / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000032:analysis / Q000633:toxicity*; D020111:Chlorodiphenyl (54% Chlorine); D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005088:Exocrine Glands / Q000187:drug effects* / Q000473:pathology; D005143:Eyelids / Q000187:drug effects*; D005260:Female; D007249:Inflammation; D008253:Macaca mulatta; D008598:Menstruation / Q000187:drug effects; D015999:Multivariate Analysis; D009262:Nails / Q000187:drug effects*; D011786:Quality Control; D011897:Random Allocation
chemical_list: D001140:Aroclors; D002273:Carcinogens; D020111:Chlorodiphenyl (54% Chlorine)