title: Aneurysmal dilatation of ductus arteriosus during lipo-prostaglandin E1 therapy for diaphragmatic hernia.
abstract: We report a case of congenital diaphragmatic hernia in which aneurysmal dilatation of ductus arteriosus developed after lipo-prostaglandin E1 (PGE1) therapy for persistent fetal circulation. After surgery Lipo-PGE1 was used at a dosage of 5 ng/kg per minute from days 2-9 during which aneurysmal dilatation (7 mm in diameter) developed and remained thereafter. Ductus arteriosus ligation was then performed. Lipo-PGE1 may promote ductus arteriosus dilatation in cases of persistent fetal circulation.
authors.affiliation: Department of Paediatrics, Shinshu University, Matsumoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tohyama
authors.forename: A
authors.initials: A
authors.lastname: Baba
authors.forename: T
authors.initials: T
authors.lastname: Tsuno
authors.forename: K
authors.initials: K
authors.lastname: Aonuma
authors.forename: A
authors.initials: A
authors.lastname: Komiyama
mesh_terms: D000527:Alprostadil / Q000627:therapeutic use*; D000783:Aneurysm / Q000209:etiology* / Q000601:surgery; D003965:Diaphragmatic Eventration / Q000150:complications* / Q000601:surgery; D004373:Ductus Arteriosus; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications* / Q000188:drug therapy*; D013537:Sutures
chemical_list: D000527:Alprostadil