The suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump: an HPLC-dynamic FAB study.
The stability of aqueous carboplatin solutions over 14 days has been studied at 37 and 60 degrees C. High-performance liquid chromatography and dynamic FAB mass spectrometry studies have shown that carboplatin solutions were stable at 37 degrees C but degraded at 60 degrees C. Fluid loss through evaporation was significant at the higher temperature.
Hadfield
J A
JA
CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
McGown
A T
AT
Dawson
M J
MJ
Thatcher
N
N
Fox
B W
BW
D016190:Carboplatin / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013696:Temperature
D016190:Carboplatin