Treatment of experimental acute corneal inflammation with inhibitors of the oxidative metabolism.
The authors studied the effect of topical 2% 6-aminonicotinamide and 0.1% adenosine on an experimental model of acute corneal inflammation. Luminol-enhanced chemiluminescence (LAC), as an indirect measurement of free-radical release, and computer-assisted planimetry of the corneal ulcer and its infiltrate were performed both ex vivo and in vivo on the fifth day following the induction of experimental alkali burn keratitis. The authors proved that both drugs significantly inhibited LAC both ex vivo and in vivo and that such treatments had also a significant beneficial effect on the evolution of the corneal ulcer and its infiltrate. To the best of the authors' knowledge, this finding had not been previously reported in experimental corneal inflammation and may indicate that treatment with inhibitors of the oxidative metabolism could offer a new approach in the pharmacological modulation of acute corneal inflammation.
Alio
J L
JL
Division of Ophthalmology, University of Alicante Medical School, San Vicente del Raspeig, Spain.
Ayala
M J
MJ
Mulet
E
E
Artola
A
A
Bellot
J L
JL
Ruiz-Moreno
J M
JM
D015120:6-Aminonicotinamide / Q000627:therapeutic use*; D000241:Adenosine / Q000627:therapeutic use*; D000287:Administration, Topical; D000818:Animals; D003320:Corneal Ulcer / Q000139:chemically induced / Q000188:drug therapy; D004195:Disease Models, Animal; D005609:Free Radicals / Q000037:antagonists & inhibitors; D007634:Keratitis / Q000139:chemically induced / Q000188:drug therapy*; D008163:Luminescent Measurements; D009883:Ophthalmic Solutions; D010084:Oxidation-Reduction; D011817:Rabbits; D012972:Sodium Hydroxide
D005609:Free Radicals; D009883:Ophthalmic Solutions; D015120:6-Aminonicotinamide; D012972:Sodium Hydroxide; D000241:Adenosine