title: Alterations in large gut associated lymphatic tissues (LGALT) during experimental colorectal carcinogenesis.
abstract: Alterations in large gut associated lymphatic tissues (LGALT) were studied histologically during 20-methylcholanthrene (MCA) induced colorectal carcinogenesis. Precancerous changes in LGALT included hyperplasia, hyperchromasia of lymphocytes and enlargement of lymphoid follicles. In addition, follicular invasion in muscular layer and cellular disorganization of diffuse lymphatic tissues were observed in neoplasia. Since, LGALT showed remarkable changes during carcinogenesis, this aspect may be considered during assessment of preneoplastic lesions, along with other histologic features of early neoplasia.
authors.affiliation: Department of Cell Biology, Chittaranjan National Cancer Institute, Calcutta, India.
authors.forename: R
authors.initials: R
authors.lastname: Baral
authors.forename: A
authors.initials: A
authors.lastname: Chakraborty
authors.forename: P
authors.initials: P
authors.lastname: Maity
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D007420:Intestine, Large / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D008748:Methylcholanthrene / Q000633:toxicity; D011230:Precancerous Conditions / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008748:Methylcholanthrene