title: Degradation products of streptozotocin do not induce hyperglycemia in rats.
abstract: The present study was conducted to determine whether degradation products of streptozotocin formed under various conditions induce hyperglycemia in rats. Streptozotocin is completely degraded in pH 7.4 buffer in 4 hr and even more rapidly in plasma. Streptozotocin degradation products resulting from incubation in pH 7.4 phosphate buffer or in plasma were not diabetogenic in rats.
authors.affiliation: College of Pharmacy, Seoul National University, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
authors.forename: M J
authors.initials: MJ
authors.lastname: Kim
authors.forename: C K
authors.initials: CK
authors.lastname: Moon
authors.forename: J H
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006863:Hydrogen-Ion Concentration; D006943:Hyperglycemia / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D013311:Streptozocin