title: Unexpected emergence of manifest preexcitation following transcatheter ablation of concealed accessory pathways.
abstract: BACKGROUND
  The basis for anterograde or retrograde unidirectional block of accessory pathways still remains a controversial issue.
  
  
  RESULTS
  Four of 19 consecutive patients (1 male, 3 female; ages 27 to 34 years) who underwent transcatheter ablation of concealed accessory pathways developed manifest preexcitation after the ablation. The location of the concealed accessory pathways in these four patients were right lateral, left posteroseptal, left posterolateral, and left lateral. Radiofrequency current was used in three of the four patients and high energy direct current in one patient. After ablation, manifest preexcitation was observed in these four patients for the first time. Manifest preexcitation developed immediately after ablation in two of the four patients and after 4 and 14 days in the other two. Detailed endocardial mapping revealed that the manifest preexcitation originated from the same location as the concealed pathways. Subsequently, catheter ablation was successfully performed in three of the four patients using radiofrequency current. One patient underwent successful surgical ablation. No recurrence of preexcitation was observed during a follow-up period of 9 to 38 months. All patients remained free of arrhythmias.
  
  
  CONCLUSIONS
  The basis for this unexpected emergence of preexcitation in these patients with only retrograde conducting accessory pathways deserves further investigation. Although not compared in the present study, this phenomenon has not been reported in patients who underwent surgical interruption of accessory pathways. We postulate that a lesion at the site of insertion of the accessory pathway had modified the anterograde conduction capacity.
authors.affiliation: Department of Cardiology and Angiology, Hospital of the Westfälische Wilhelms-University of Münster, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Willems
authors.forename: M
authors.initials: M
authors.lastname: Shenasa
authors.forename: M
authors.initials: M
authors.lastname: Borggrefe
authors.forename: K
authors.initials: K
authors.lastname: Seidl
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Hindricks
authors.forename: W
authors.initials: W
authors.lastname: Haverkamp
authors.forename: G
authors.initials: G
authors.lastname: Breithardt
mesh_terms: D000328:Adult; D017115:Catheter Ablation; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000209:etiology; D006801:Humans; D008297:Male; D011226:Pre-Excitation Syndromes / Q000209:etiology*; D013617:Tachycardia, Supraventricular / Q000503:physiopathology* / Q000628:therapy