Fertile females of the mole Talpa occidentalis are phenotypic intersexes with ovotestes.
We investigated the origin of XX sex reversal in the insectivorous mole Talpa occidentalis. Cytogenetic, histological and hormonal studies indicate that all XX individuals analyzed from two different populations are true hermaphrodites, with ovotestes. This suggests that XX sex reversal may be the norm in this species. The intersexes are functional fertile females and the trait is transmitted and maintained in the population. Intersexes lack the Y chromosome gene SRY (sex determining region Y gene), shown to be the testis determining gene. These results suggest that XX intersex moles may have arisen from a mutation of a gene located downstream from SRY/TDY in the testis determining pathway.
Jiménez
R
R
Departamento de Genética, Facultad de Ciencias, Universidad de Granada, Spain.
Burgos
M
M
Sánchez
A
A
Sinclair
A H
AH
Alarcón
F J
FJ
Marín
J J
JJ
Ortega
E
E
Díaz de la Guardia
R
R
D000818:Animals; D015139:Blotting, Southern; D004268:DNA-Binding Proteins / Q000235:genetics; D012734:Disorders of Sex Development; D005260:Female; D007621:Karyotyping; D008297:Male; D008854:Microscopy, Electron; D008971:Moles / Q000033:anatomy & histology / Q000097:blood / Q000235:genetics*; D009687:Nuclear Proteins; D010053:Ovary / Q000033:anatomy & histology*; D012732:Sex Determination Analysis; D051876:Sex-Determining Region Y Protein; D013737:Testis / Q000033:anatomy & histology* / Q000196:embryology / Q000648:ultrastructure; D013739:Testosterone / Q000097:blood; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors; D013739:Testosterone