Successful treatment of AIDS-related cryptosporidial sclerosing cholangitis.
OBJECTIVE
Cryptosporidium is a well recognized cause of AIDS-related sclerosing cholangitis for which no efficacious therapy exists at present. We evaluated the efficiency of the combination of paromomycin and letrazuril in the treatment of this condition.


METHODS
We report a case of cryptosporidial cholangitis in a patient with AIDS who responded to treatment with intravenous paromomycin followed by oral letrazuril as maintenance therapy.


CONCLUSIONS
The combination of paromomycin and letrazuril should be considered in the treatment of AIDS-related sclerosing cholangitis.
Hamour
A A
AA
Department of Infectious Diseases and Tropical Medicine, University of Manchester, UK.
Bonnington
A
A
Hawthorne
B
B
Wilkins
E G
EG
D000097:Acetonitriles / Q000627:therapeutic use*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000818:Animals; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D003049:Coccidiostats / Q000627:therapeutic use*; D003458:Cryptosporidium / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010303:Paromomycin / Q000627:therapeutic use*; D014227:Triazines / Q000627:therapeutic use*
D000097:Acetonitriles; D003049:Coccidiostats; D014227:Triazines; D010303:Paromomycin; C080736:letrazuril