title: Detection of antibodies to serum IgA and IgG in peptic ulcer cases by indirect haemagglutination test.
abstract: Autoantibodies to serum IgA and IgG were detected in 206 peptic ulcer patients (196 duodenal ulcer and 10 gastric ulcer) and 52 healthy age and sex-matched controls by indirect haemagglutination test. A significantly increased mean titre of autoantibodies to serum IgA was observed in the peptic ulcer patients. Forty-eight (24.61%) duodenal ulcer cases had autoantibody titre values above mean +/- 2 SD of controls. Titres of autoantibodies to serum IgG were significantly increased only in the gastric ulcer cases. The results suggest an immunologic abnormality in a sizeable fraction of these cases.
authors.affiliation: Department of Genetics, Osmania University, Hyderabad, India.
authors.forename: S
authors.initials: S
authors.lastname: Begum
authors.forename: M
authors.initials: M
authors.lastname: Ishaq
authors.forename: C M
authors.initials: CM
authors.lastname: Habibullah
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D004381:Duodenal Ulcer / Q000276:immunology; D006386:Hemagglutination Tests; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D010437:Peptic Ulcer / Q000276:immunology*; D013276:Stomach Ulcer / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G