The human phenolsulphotransferase polymorphism is determined by the level of expression of the enzyme protein.
We have examined the expression of platelet phenolsulphotransferase (PST) in 60 individuals. Using an antibody which recognizes both forms of PST present in man (P-PST and M-PST), we determined that the polymorphism of platelet P-PST activity is determined by the level of expression of the enzyme protein. The implications for susceptibility to adverse drug reactions and chemical carcinogenesis are discussed.
Jones
A L
AL
Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, U.K.
Roberts
R C
RC
Coughtrie
M W
MW
D015239:Arylsulfotransferase / Q000097:blood* / Q000235:genetics* / Q000302:isolation & purification; D001792:Blood Platelets / Q000201:enzymology*; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003600:Cytosol / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D015151:Immunoblotting; D007527:Isoenzymes / Q000097:blood / Q000235:genetics* / Q000302:isolation & purification; D011110:Polymorphism, Genetic
D007527:Isoenzymes; D015239:Arylsulfotransferase