Bioconversion of arteannuin B to artemisinin.
Arteannuin B, which co-occurs with artemisinin, the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae), has been converted to the latter using crude and semi-purified cell-free extracts of the leaf homogenates of the plant. Detection procedures to quantitate this bioconversion, including one that is novel which uses gcms, are detailed.
Nair
M S
MS
Department of Biological Sciences, H.H. Lehman College of CUNY, The Bronx, New York 10468.
Basile
D V
DV
D037621:Artemisinins; D002474:Cell-Free System; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D008516:Medicine, Chinese Traditional; D010944:Plants / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D014462:Ultrafiltration
D037621:Artemisinins; D012717:Sesquiterpenes; C006634:arteannuin B; C031327:artemisinin