title: Effect of ionic contrast medium on plasma atrial natriuretic peptide.
abstract: To evaluate the effect of ionic contrast medium on plasma atrial natriuretic peptide (ANP) and its contributing factors, we measured plasma ANP, serum osmolality, pulmonary capillary wedge pressure (PCWP), femoral artery systolic pressure (FASP), and heart rate before and after left ventriculography with Rayvist in 13 patients suspected of coronary artery disease. The control values of plasma ANP, serum osmolality, and PCWP were 20.3 +/- 5.1 pg/ml, 293.5 +/- 1.5 mosm/kg, 6.6 +/- 0.8 mm Hg, respectively. Rayvist produced a significant increase in plasma ANP, serum osmolality, and PCWP at 1 minute (26.0 +/- 6.3 pg/ml, p < 0.05; 300.7 +/- 1.9 mosm/Kg, p < 0.001; 10.7 +/- 1.3 mm Hg, p < 0.001) and 5 minutes (27.3 +/- 6.3 pg/ml, p < 0.01; 296.8 +/- 1.9 mosm/Kg, p < 0.001; 10.4 +/- 1.7 mm Hg, p < 0.01) post left ventriculography. The FASP decreased significantly at 1 minute, followed by an insignificant increase at 5 minutes. The heart rate increased significantly at 1 minute but no significant change was noted at 5 minutes. We conclude that plasma ANP increases significantly after left ventriculography with Rayvist and its response may be related to left ventricular filling pressure and serum osmolality, but not to FASP or heart rate.
authors.affiliation: Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: W C
authors.initials: WC
authors.lastname: Voon
authors.forename: S H
authors.initials: SH
authors.lastname: Sheu
authors.forename: H W
authors.initials: HW
authors.lastname: Yen
authors.forename: J S
authors.initials: JS
authors.lastname: Chang
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: W T
authors.initials: WT
authors.lastname: Lai
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D015635:Radionuclide Ventriculography
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid; D009320:Atrial Natriuretic Factor; C019462:meglumine ioglicinate