Selective parathyroidectomy of the dog.
Selective parathyroidectomy (PTX) is preferred to thyroparathyroidectomy (TPTX) when specific effects of parathyroid hormone depletion are being studied. However, because of the anatomic proximity of thyroid and parathyroid glands, TPTX often is performed, leaving animals depleted of thyroxine (T4) and calcitonin as well as parathyroid hormone (PTH). In the present study, six normal dogs had parathyroid tissue and about seven-eighths of thyroid tissue removed. This quantity of thyroid tissue was inadequate to maintain normal serum T4 concentrations, despite allowance of 168 days for thyroid recovery. Five of six dogs with reduced renal mass had successful selective PTX and normal serum T4 concentrations at 28 days, when one-half or more of thyroid tissue was spared. We conclude that with attention to the surgical technique, selective PTX can be achieved in a high percentage of dogs and sufficient thyroid tissue spared to maintain euthyroidism.
Finco
D R
DR
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Brown
S A
SA
Ferguson
D C
DC
Crowell
W A
WA
D000818:Animals; D002118:Calcium / Q000097:blood; D004283:Dog Diseases / Q000209:etiology / Q000503:physiopathology; D004285:Dogs / Q000601:surgery*; D005260:Female; D006996:Hypocalcemia / Q000209:etiology / Q000662:veterinary; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000662:veterinary; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000662:veterinary*; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy / Q000662:veterinary; D013974:Thyroxine / Q000097:blood
D010281:Parathyroid Hormone; D013974:Thyroxine; D002118:Calcium