Immunobiology of the human placental trophoblast.
Trophoblastic cells use several biological strategies to protect the embryo from potential immunological attack by the mother. The most important are the absence of major histocompatibility antigens, the presence of unique non-polymorphic HLA molecules (HLA-G), and the expression of complement regulatory proteins. The role of these factors is analysed in the light of recent studies.
Johnson
P M
PM
Department of Immunology, University of Liverpool, UK.
D000026:Abortion, Habitual / Q000276:immunology; D015703:Antigens, CD / Q000096:biosynthesis / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D005260:Female; D005786:Gene Expression Regulation; D006680:HLA Antigens / Q000096:biosynthesis / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D014327:Trophoblasts / Q000276:immunology*
D015703:Antigens, CD; C497857:CD46 protein, human; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D003165:Complement System Proteins