title: Impact of omeprazole on the plasma clearance of methotrexate.
abstract: Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.
authors.affiliation: Department of Medicine, Stanford University Medical Center, CA 94305.
authors.forename: T
authors.initials: T
authors.lastname: Reid
authors.forename: A
authors.initials: A
authors.lastname: Yuen
authors.forename: M
authors.initials: M
authors.lastname: Catolico
authors.forename: R W
authors.initials: RW
authors.lastname: Carlson
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy; D000075202:Contraindications; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008727:Methotrexate / Q000097:blood / Q000493:pharmacokinetics*; D009853:Omeprazole; D012516:Osteosarcoma / Q000097:blood / Q000188:drug therapy
chemical_list: D009853:Omeprazole; D008727:Methotrexate