New platinum(II) complexes of beta-cyclodextrin diamine derivatives and their antitumor activity.
The new platinum(II) complexes of beta-cyclodextrin functionalized at the primary position with ethylenediamine or with propylenediamine were synthesized and characterized by mass spectrometry, electronic spectrophotometry, and multinuclear NMR spectroscopy. Platinum(II) complexation makes the cavity more asymmetric. These complexes were tested in vitro for their cytotoxic activity. The relevance of the low activity observed regarding the interaction between the cell and the cyclodextrin cavity is discussed.
Cucinotta
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Dipartimento di Scienze Chimiche, Università di Catania, Italy.
Mangano
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A
Nobile
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Santoro
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AM
Vecchio
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G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004247:DNA / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013053:Spectrophotometry; D014407:Tumor Cells, Cultured; D047392:beta-Cyclodextrins
D000970:Antineoplastic Agents; D003505:Cyclodextrins; D009944:Organoplatinum Compounds; D047392:beta-Cyclodextrins; C084713:dichloro(6-(ethylenediamine)-beta-cyclodextrin)platinum(II); C084714:dichloro(6-(propylenediamine)-beta-cyclodextrin)platinum(II); D004247:DNA