title: A transforming growth factor beta type I receptor that signals to activate gene expression.
abstract: Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.
authors.affiliation: Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
authors.forename: C H
authors.initials: CH
authors.lastname: Bassing
authors.forename: J M
authors.initials: JM
authors.lastname: Yingling
authors.forename: D J
authors.initials: DJ
authors.lastname: Howe
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: W W
authors.initials: WW
authors.lastname: He
authors.forename: M L
authors.initials: ML
authors.lastname: Gustafson
authors.forename: P
authors.initials: P
authors.lastname: Shah
authors.forename: P K
authors.initials: PK
authors.lastname: Donahoe
authors.forename: X F
authors.initials: XF
authors.lastname: Wang
mesh_terms: D000818:Animals; D002460:Cell Line; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D016297:Mutagenesis, Site-Directed; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D015398:Signal Transduction; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II