title: Genomic sequence of mouse COL1A1 encoding the collagen propeptides.
abstract: The nucleotide sequences of the mouse pro alpha 1(I) gene regions coding for the N- and C-propeptides is reported. The exon-intron structure was highly homologous to human COL1A1 and the deduced amino acid sequences of the N- and C-propeptides showed 67% and 91% identity with the human sequence. This gene sequence information will allow the production of specific gene mutations by site-directed mutagenesis to study the structure and function of these important propeptide domains.
authors.affiliation: Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Australia.
authors.forename: S P
authors.initials: SP
authors.lastname: Fenton
authors.forename: S R
authors.initials: SR
authors.lastname: Lamande
authors.forename: M
authors.initials: M
authors.lastname: Hannagan
authors.forename: A
authors.initials: A
authors.lastname: Stacey
authors.forename: R
authors.initials: R
authors.lastname: Jaenisch
authors.forename: J F
authors.initials: JF
authors.lastname: Bateman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D005091:Exons; D015186:Hominidae / Q000235:genetics; D006801:Humans; D007438:Introns; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D011347:Procollagen / Q000235:genetics*; D012326:RNA Splicing; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011347:Procollagen