title: An open study of oral flesinoxan, a 5-HT1A receptor agonist, in treatment-resistant depression.
abstract: Flesinoxan, a full 5-HT1A receptor agonist, was administered (4-8 mg) to treatment-resistant depressed patients in an open study. Safety and tolerance of the substance appeared satisfactory. Headache, dizziness and nausea were the most frequently reported side effects. The observations suggested that flesinoxan is an antidepressant agent and that it may be of particular value in some difficult, treatment-resistant depressions. Based on these observations, a double-blind, placebo-controlled evaluation of flesinoxan's efficacy appears warranted.
authors.affiliation: Department of Psychiatry, University of Ottawa, Royal Ottawa Hospital, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Grof
authors.forename: R
authors.initials: R
authors.lastname: Joffe
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
authors.forename: E
authors.initials: E
authors.lastname: Persad
authors.forename: J
authors.initials: J
authors.lastname: Syrotiuk
authors.forename: D
authors.initials: D
authors.lastname: Bradford
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011985:Receptors, Serotonin / Q000187:drug effects*
chemical_list: D000928:Antidepressive Agents; D010879:Piperazines; D011985:Receptors, Serotonin; C056895:flesinoxan