Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
34-Sulfatobastadin 13 [1] was isolated from the sponge Ianthella sp. Its structure was elucidated by nmr techniques and chemical transformation to bastadin 13 [2]. Compound 1 weakly inhibited binding to the endothelin A receptor (ETA), while compound 2 inhibited growth of Bacillus subtilis.
Gulavita
N K
NK
Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946.
Wright
A E
AE
McCarthy
P J
PJ
Pomponi
S A
SA
Kelly-Borges
M
M
Chin
M
M
Sills
M A
MA
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D065128:Endothelin Receptor Antagonists; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013552:Swine
D065128:Endothelin Receptor Antagonists; D010456:Peptides, Cyclic; D010647:Phenyl Ethers; C084704:34-sulfabastadin 13