The toxicity of seed extracts and their fractions from Lupinus angustifolius L. and Lupinus albus L.
Seed extracts obtained from Lupinus albus and Lupinus angustifolius by treatment with 48% ethanol contained ca. 10% alkaloids (on a dry weight basis) and were non-toxic. Their acute toxicity (LD50) in the mouse is > 4000 mg kg-1 body wt. After fractionation, the extract from L. angustifolius seeds afforded several fractions with differing toxicities (LD50 750-4000 mg kg-1 body wt.). None of the fractions tested in vitro were toxic. The results obtained showed that, in spite of the alkaloids, other low-molecular-weight constituents present significantly modified the toxicity of the lupin extracts.
Stobiecki
M
M
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań.
Blaszczyk
B
B
Kowalczyk-Bronisz
S H
SH
Gulewicz
K
K
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000633:toxicity*; D012639:Seeds / Q000737:chemistry*
D000470:Alkaloids; D010936:Plant Extracts