The topical application of verapamil and nifedipine lowers intraocular pressure in conscious rabbits.
1. The time-course of the ocular effects of topical verapamil and nifedipine as well as the dose-response relationship, were studied in conscious, normotensive rabbits. 2. Both drugs caused a dose-dependent fall of intraocular pressure, which lasted 4 hr or more. 3. Log dose-response curves of both drugs show a similar peak response, but the potency of verapamil was greater that of nifedipine. 4. A fall in the intraocular pressure in the untreated eye was also observed. 5. Verapamil and nifedipine induced a reduction of the tonographic outflow facility in the treated eye.
Segarra
J
J
Departmento de Farmacología, Facultad de Farmacia, Universidad del País Vasco, Vitoria, Spain.
Santafé
J
J
Garrido
M
M
Martínez de Ibarreta
M J
MJ
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007429:Intraocular Pressure / Q000187:drug effects*; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D014700:Verapamil; D009543:Nifedipine