[A case of pulmonary aspergilloma successfully treated with combination therapy of intracavitary injection of amphotericin B and intravenous administration of urinastatin].
A 57-year-old man with pulmonary tuberculosis underwent left upper lobectomy in 1984. In 1987, chest X-ray showed a fungus ball, and Aspergillus species was isolated from sputum. He was treated by intracavitary injection of amphotericin B (AMPH) in June, 1992. However, no change was observed in the chest CT scan after a total dose of 1,000 mg of AMPH. Combination therapy of intravenous administration of 100,000 units of urinastatin and intracavitary injection of AMPH resulted in complete disappearance of the fungus ball on chest CT scan. This report describes case of pulmonary aspergilloma successfully treated with the combination of AMPH and urinastatin.
Maesaki
S
S
Second Department of Internal Medicine, Nagasaki University School of Medicine.
Kohno
S
S
Tanaka
K
K
Miyazaki
H
H
Mitsutake
K
K
Miyazaki
T
T
Tomono
K
K
Kaku
M
M
Koga
H
H
Hara
K
K
D000666:Amphotericin B / Q000008:administration & dosage; D001228:Aspergillosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D006023:Glycoproteins / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D015552:Injections, Intralesional; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D006023:Glycoproteins; D000666:Amphotericin B; C028665:urinastatin