title: Evaluation of vanillic acid analogues as a new class of antifilarial agents.
abstract: A number of vanillic acid analogues (1-14) have been synthesised and evaluated against experimental filarial infections using cotton rats (Sigmodon hispidus) infected with Litomosoides carinii, a primary screening model, at a dose of 30 mg/kg, ip for 5 days. Of the 8 compounds tested, 4 (5,7, 11 and 12) exhibited high micro- and macro-filaricidal activity with sterilization of surviving female worms. Compounds 5, 7, 12 showed remarkable adulticidal action (> 80%). Sterilization of the female worms by compounds 11 and 12 was highly significant (80-100%).
authors.affiliation: Department of Chemistry, Lucknow University, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Varma
authors.forename: A
authors.initials: A
authors.lastname: Shukla
authors.forename: R K
authors.initials: RK
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D005369:Filaricides / Q000737:chemistry / Q000494:pharmacology*; D005370:Filarioidea / Q000187:drug effects*; D008297:Male; D016205:Sigmodontinae; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005369:Filaricides; D014641:Vanillic Acid