title: Postoperative multiple organ dysfunction syndrome associated with gut mucosal hypoperfusion, increased neutrophil degranulation and C1-esterase inhibitor depletion.
abstract: We have examined the relationship between gut mucosal perfusion, as determined by gastric intramucosal pH (pHi), changes in plasma neutrophil elastase concentrations and components of the contact system during elective major surgery and related these findings to patient outcome. Of the 26 patients studied, 16 developed gut mucosal hypoperfusion (pHi < 7.32) by the end of surgery; four of these developed multiple organ dysfunction syndrome; three of these died. In this group there was a significant increase in neutrophil elastase (P < 0.005) and significant reductions in plasma components of the contact system from immediately before surgery to 24 h later. Ten patients maintained gut mucosal perfusion (pHi > or = 7.32); none of these developed life threatening complications. In this group there was no significant increase in neutrophil elastase and, although there were significant reductions in some plasma components of the contact system, concentrations of C1-esterase inhibitor (the main inhibitor of the contact system) were not significantly reduced. We conclude that gut mucosal hypoperfusion, neutrophil degranulation and activation of the contact system to the extent that C1-esterase inhibitor becomes depleted are associated with a poor outcome after major surgery.
authors.affiliation: Bloomsbury Institute of Intensive Care Medicine, Middlesex Hospital, London.
authors.forename: M G
authors.initials: MG
authors.lastname: Mythen
authors.forename: G
authors.initials: G
authors.lastname: Purdy
authors.forename: I J
authors.initials: IJ
authors.lastname: Mackie
authors.forename: T
authors.initials: T
authors.lastname: McNally
authors.forename: A R
authors.initials: AR
authors.lastname: Webb
authors.forename: S J
authors.initials: SJ
authors.lastname: Machin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000098:blood supply*; D007511:Ischemia / Q000150:complications*; D019272:Leukocyte Elastase; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology*; D009504:Neutrophils / Q000502:physiology; D010196:Pancreatic Elastase / Q000097:blood; D011183:Postoperative Complications / Q000097:blood; D011379:Prognosis
chemical_list: D003174:Complement C1 Inactivator Proteins; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase