title: SOS mutagenesis.
abstract: In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires some form of DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. An analysis of SOS mutagenesis offers insights into the molecular basis of induced mutagenesis and into mechanisms of DNA damage tolerance.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: S
authors.initials: S
authors.lastname: Murli
authors.forename: G C
authors.initials: GC
authors.lastname: Walker
mesh_terms: D004249:DNA Damage; D004926:Escherichia coli / Q000235:genetics*; D016296:Mutagenesis; D013014:SOS Response, Genetics / Q000235:genetics*