[The tyrosine kinases of the Src family: properties and roles in cells].
The protein tyrosine kinases (PTK) are implicated in cell proliferation processes. Furthermore, a number of viral oncogenes encode constitutively active variants of tyrosine kinases and several growth factor receptors possess intrinsic tyrosine kinase activity. The regulation and biological function of the kinase activity of Src family PTK are not yet well established. However, three of these kinases (src, yes and fgr) have been initially identified as products of viral oncogenes and a fourth (lck) is activated and overexpressed in certain lymphomas. In fact, several biological systems implicate and early and transient activation of Scr family PTK.
Danielian
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INSERM U29, Hôpital de Port-Royal, Paris, France.
D016391:Genes, src / Q000235:genetics; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D009857:Oncogenes / Q000235:genetics; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000737:chemistry / Q000502:physiology
D006133:Growth Substances; D017978:Receptors, Growth Factor; D011505:Protein-Tyrosine Kinases
Les tyrosine kinases de la famille Src: propriétés et rôles dans la cellule.