Modelling of serial carcinoembryonic antigen changes in colorectal cancer.
Carcinoembryonic antigen (CEA) is a tumour marker mainly used for detection of recurrent colorectal cancer. CEA series in 295 patients, who had a macroscopic radical resection of a primary colorectal cancer were studied. A kinetic model was fitted to CEA series of individual patients. Applying the kinetic model recurrences were identified with a sensitivity of 70-80% and specificity of 80-90%. Simulations were performed in order to find the optimal sampling strategy for CEA during follow-up. Simulations showed that CEA determinations at a few weeks interval between would be optimal for early detection of recurrences.
Carl
J
J
Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus.
Bentzen
S M
SM
Nørgaard-Pedersen
B
B
Kronborg
O
O
D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009364:Neoplasm Recurrence, Local / Q000097:blood
D002272:Carcinoembryonic Antigen