title: [Brain metastasis of rhabdomyosarcoma with intratumorous hemorrhage: a case report and literature review].
abstract: A 56-year-old male suffered from primary rhabdomyosarcoma on the left internal thoracic wall, which was treated by chemotherapy, and local irradiation following biopsy. Four months after the diagnosis, he suddenly complained of headache and left paresthesia occurred followed by generalized convulsion and left hemiplegia. CT scan revealed a high density mass in the right parietal lobe. The patient was referred to our department and underwent emergency evacuation of the hematoma together with tumor removal. The pathological specimen showed spindle or oval-like cells with hypercellularity and some mitotic figures. Immunohistochemical study demonstrated that many cells were positive for desmin and myoglobin, which is specific to myogenic tumor. These characteristics were compatible with those of the primary thoracic lesion, and a diagnosis of metastatic rhabdomyosarcoma was made. Five weeks after the craniotomy, the metastatic brain tumor recurred in the same site and also in the bilateral occipital lobes. Although radiotherapy to the brain decreased the tumor size, the patient died of respiratory failure eleven and a half months after the initial diagnosis. Sarcomas metastasizing to the brain are rare and only 16 cases of rhabdomyosarcoma metastasizing to the brain have been reported so far. Recent advances in chemotherapy, however, have been able to show the increased incidence of sarcoma metastasis to the brain. Therefore, the necessity of follow-up CT scan for sarcoma patients of long survival is to be stressed, even if the patient shows no neurological symptoms.
authors.affiliation: Department of Neurosurgery, Sendai City Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Uyeno
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Onuma
authors.forename: A
authors.initials: A
authors.lastname: Kikuchi
authors.forename: R
authors.initials: R
authors.lastname: Ichinohasama
mesh_terms: D001932:Brain Neoplasms / Q000098:blood supply / Q000150:complications / Q000556:secondary*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012208:Rhabdomyosarcoma / Q000098:blood supply / Q000150:complications / Q000556:secondary*; D013899:Thoracic Neoplasms / Q000473:pathology*