Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist".
Simoni
D
D
Mayo Foundation for Medical Education and Research, Jacksonville, Florida 32224.
Stoelwinder
J
J
Kozikowski
A P
AP
Johnson
K M
KM
Bergmann
J S
JS
Ball
R G
RG
D003042:Cocaine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D008454:Mazindol / Q000378:metabolism; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C084740:methyl 3-benzoyloxy-7-methoxy-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylate; D008454:Mazindol; D003042:Cocaine; D004298:Dopamine