title: Spatiotemporal observation of guinea pig auditory cortex with optical recording.
abstract: The spatiotemporal characteristics of neural activity in the guinea pig auditory cortex were studied in order to clarify neural processing and coding mechanisms of complex sounds. We used a multi-channel optical recording system for a voltage-sensitive dye: RH795. The experimental results showed that a boomerang-shaped moving pattern of optical response appeared on the cortical surface in response to complex sounds (clicks) stimulation, but a rather fixed pattern appeared in response to tone burst stimulation. The tonotopical organization observed using microelectrode was not directly visible, but a similar topographic pattern was evidenced by selecting regions of a strong response evoked by tone-bursts. The correlative functions of regionwide responses may indicate a parallel and serial neural processing structure.
authors.affiliation: Advanced Research Laboratory, Hitachi Ltd., Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fukunishi
authors.forename: N
authors.initials: N
authors.lastname: Murai
authors.forename: H
authors.initials: H
authors.lastname: Uno
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001931:Brain Mapping; D004396:Coloring Agents; D004594:Electrophysiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006168:Guinea Pigs; D008297:Male; D013028:Space Perception / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*
chemical_list: D004396:Coloring Agents