[The pharmacological options for an immediate intervention in threatened premature labor].
The following preparations, with different mechanism of action, have been comparatively tested for induction of immediate tocolysis in case of threatened preterm labour: Hyoscine butylbromide, ritodrine, ketoprofen and the association of ritodrine with ketoprofen. Hyoscine butylbromide was found to be very easy to handle, but its myolytic effect is modest. Ritodrine and ketoprofen have shown a high and quantitatively similar tocolytic power. But even better results have been achieved with the association of ritodrine with ketoprofen which has shown a total myolytic effect. The authors suggest some hypotheses concerning the mechanism of action of these drugs, and some precautions for their correct clinical use.
Scarpellini
L
L
Insegnamento di Puericultura Prenatale, II Istituto di Clinica Ostetrica e Ginecologica, Università degli Studi di Roma La Sapienza.
Scarpellini
F
F
Spina
V
V
D000293:Adolescent; D000328:Adult; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D010298:Parity; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012312:Ritodrine / Q000008:administration & dosage
D002086:Butylscopolammonium Bromide; D007660:Ketoprofen; D012312:Ritodrine
Opzioni farmacologiche per un intervento immediato nella minaccia di parto pretermine.