Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats.
Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens. The T3 antagonized oxotremorine-induced hypothermia and failed to antagonize eserine hypothermic effect, but potentiated oxotremorine- and eserine-induced tremors. Acetylcholinesterase activity was not altered in T3 rats. The hypothetical mechanisms to explain changes of central cholinergic responses caused by T3 are discussed.
Almeida
O M
OM
Departamento de Farmacologia e Psicobiologia, Universidade de Estado do Rio de Janeiro, Brasil.
Santos
R
R
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D006980:Hyperthyroidism / Q000139:chemically induced / Q000503:physiopathology; D007035:Hypothermia / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010095:Oxotremorine; D010277:Parasympathomimetics / Q000494:pharmacology*; D010830:Physostigmine; D051381:Rats; D017208:Rats, Wistar; D014202:Tremor / Q000139:chemically induced / Q000517:prevention & control*; D014284:Triiodothyronine / Q000494:pharmacology*
D010277:Parasympathomimetics; D014284:Triiodothyronine; D010095:Oxotremorine; D010830:Physostigmine; D000110:Acetylcholinesterase