title: Nedocromil sodium vs. sodium cromoglycate pressurized aerosol in the prevention of bronchoconstriction induced by ultrasonic nebulized distilled water in asthmatic children.
abstract: To compare the effectiveness of nedocromil sodium (NS) and sodium cromoglycate (SCG), administered by metered dose inhaler (MDI) with a 700 mL holding chamber (Fisonair Fisons UK) in preventing bronchoconstriction induced by inhalation of ultrasonically nebulized distilled water (UNDW), 12 asthmatic children were studied in a randomized, double-blind, placebo-controlled, intrapatient study. Following a baseline challenge with UNDW, the protective effect of NS, SCG, or placebo was evaluated in each subject. Cumulative doses of delivered nebulized water producing a 20% fall in forced expiratory volume in 1 sec (PD20 UNDW) was measured. Mean (+/- SD) PD20 UNDW was 4.83 (+/- 4.84), 10.16 (+/- 7.05), 1.58 (+/- 0.5), and 15.93 (+/- 0.23) respectively, for baseline, and placebo, SCG, and NS-treated groups. A significant (P < 0.05) protection from UNDW induced bronchoconstriction by NS was observed in comparison with placebo, while no such effect was evident when the children were treated with SCG.
authors.affiliation: Instituto Pio XII Misurina (BL), University of Verona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Spezia
authors.forename: G
authors.initials: G
authors.lastname: Del Col
authors.forename: C
authors.initials: C
authors.lastname: Richelli
authors.forename: L
authors.initials: L
authors.lastname: Sette
authors.forename: A L
authors.initials: AL
authors.lastname: Boner
mesh_terms: D000293:Adolescent; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001985:Bronchial Provocation Tests / Q000379:methods; D016084:Bronchoconstriction / Q000187:drug effects*; D002648:Child; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D017835:Nedocromil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000336:Aerosols; D017835:Nedocromil; D004205:Cromolyn Sodium