title: Sevoflurane does not increase intracranial pressure in hyperventilated dogs.
abstract: We have measured the effects of 0.5, 1.0 and 1.5 MAC (minimum alveolar concentration) end-tidal concentrations of sevoflurane on intracranial pressure (ICP), cerebral perfusion pressure (CPP), mean arterial pressure (MAP), central venous pressure and heart rate in hypocapnic dogs (PaCO2 3.2-3.7 kPa) and compared the data with those produced by equi-MAC concentrations of enflurane and halothane. Enflurane and halothane caused small but significant increases in ICP at 0.5, 1.0 and 1.5 MAC, but there were no changes with sevoflurane. However, sevoflurane caused a considerable decrease in MAP with consequent decrease in CPP. We conclude that sevoflurane should be a suitable agent for neuroanaesthesia and is preferable to either enflurane or halothane.
authors.affiliation: Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Murata
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000768:Anesthesia, General; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002496:Central Venous Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007427:Intracranial Pressure / Q000187:drug effects*; D008738:Methyl Ethers; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; D004737:Enflurane; D006221:Halothane