title: Expression of bcl-2 in small cell lung carcinoma cells.
abstract: We have investigated the expression of bcl-2 protein in a panel of small cell lung carcinoma (SCLC) cells lines. Five of six cell lines examined expressed relatively high levels of bcl-2 protein and transcripts. The bcl-2 expression in SCLC cells, however, was not always associated with myc expression. Since dysregulation of bcl-2 may be involved in the course of tumorigenesis and/or in the acquisition of drug resistance of tumor cells, the expression of bcl-2 in SCLC cells may become an important indicator in the prognosis or treatment of SCLC.
authors.affiliation: Department of Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia 19104.
authors.forename: N
authors.initials: N
authors.lastname: Ikegaki
authors.forename: M
authors.initials: M
authors.lastname: Katsumata
authors.forename: J
authors.initials: J
authors.lastname: Minna
authors.forename: Y
authors.initials: Y
authors.lastname: Tsujimoto
mesh_terms: D018288:Carcinoma, Small Cell / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry*; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis*; D014407:Tumor Cells, Cultured
chemical_list: D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc