[Correction of disorders in the monooxygenase system function with diethylnicotinamide (cordiamine) in tetrachloromethane- induced and viral hepatitis].
Content of cytochromes P-450 and b5 and the rate of oxidative dealkylation in liver microsomes as well as the antipyrine pharmacokinetics were normalized in rats with acute CCl4-induced hepatitis after treatment with cordiamine (diethyl nicotinamide) at a dose of 40 mg, subcutaneously, 2 times daily within 4 days. Cordiamine (30 drops 3 times daily within 8 days) contributed to normalization of the hydroxylating reaction in liver tissue of patients with viral hepatitis A, estimated by the "antipyrine" test. The drug exhibited stabilizing effect on hydrophobic interactions in microsomal membranes; diethyl nicotinamide possessed antiradical and vitamin properties.
Zavodnik
L B
LB
Lukienko
P I
PI
Bushma
M I
MI
Shoka
A Iu
AIu
Tsyrkunov
V M
VM
D000293:Adolescent; D000328:Adult; D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D065607:Cytochrome P-450 Enzyme Inhibitors; D015786:Cytochromes b5 / Q000037:antagonists & inhibitors*; D005260:Female; D006506:Hepatitis A / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009552:Nikethamide / Q000627:therapeutic use*; D051381:Rats
D065607:Cytochrome P-450 Enzyme Inhibitors; D009552:Nikethamide; D015786:Cytochromes b5; D002251:Carbon Tetrachloride
Korrektsiia diétilnikotinamidom (kordiaminom) narusheniia funktsii monooksigenaznoĭ sistemy pri tetrakhlormetanovom i virusnom gepatitakh.