title: Proactive interference and the neuropsychology of schizophrenia.
abstract: Gray, Felden, Rawlins, Hemsley & Smith (1991) have proposed a theoretical model of the neuropsychology of schizophrenia. A major feature of this model is that it is a weakening of the influences of memories of previous input on current perception/learning which is basic to the phenomenon of acute schizophrenia. In the present study, proactive interference (PI) was used as a paradigm to test this hypothesis. PI occurs when new learning is diminished as a consequence of previously learned material. According to our reading of the Gray et al. (1991) model, acutely ill unmedicated patients with schizophrenia should demonstrate reduced PI relative to controls. Ten acutely ill unmedicated patients with schizophrenia, 20 patients suffering from major depressive disorder, and 20 healthy controls were assessed using a PI paradigm. No significant differences in PI emerged between the groups. The results do not support this specific feature of the neuropsychological model of acute schizophrenia proposed by Gray et al. (1991).
authors.affiliation: MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Scotland.
authors.forename: R E
authors.initials: RE
authors.lastname: O'Carroll
authors.forename: C
authors.initials: C
authors.lastname: Murray
authors.forename: M P
authors.initials: MP
authors.lastname: Austin
authors.forename: K P
authors.initials: KP
authors.lastname: Ebmeier
authors.forename: G M
authors.initials: GM
authors.lastname: Goodwin
authors.forename: J
authors.initials: J
authors.lastname: Dunan
mesh_terms: D000161:Acoustic Stimulation; D000208:Acute Disease; D000328:Adult; D001307:Auditory Perception; D003866:Depressive Disorder / Q000175:diagnosis; D005260:Female; D006801:Humans; D007807:Language Tests; D007858:Learning; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis*