Sex-dependent urolithiasis in the portacaval shunt rat. 2. Hormones and stone formation.
Sex-dependent stone formation following portacaval shunt (PCS) was investigated in 82 male and 71 female Sprague-Dawley rats. 72.6% of male PCS rats and none of the female PCS rats developed urolithiasis, in 90.2%, potassium-hydrogen-urate stones formed. Hormonal analysis revealed significant alterations in steroid hormones and glucagon postoperatively. Male PCS rats showed a significant decrease in total and free testosterone and an increase in estradiol and glucagon levels. Female PCS rats showed a marked rise in testosterone and glucagon levels as well as a decrease in estradiol plasma levels. Male PCS rats had higher urinary and plasma uric acid concentrations compared to female PCS and sham-operated rats. Loss of testosterone and rise of glucagon in males was correlated with urolithiasis in so far as stone-forming rats had higher concentrations than non-stone-forming PCS rats. Our findings suggest that hormonal alterations might contribute to sex-dependent stone formation in PCS rats.
Heidenreich
A
A
Department of Urology, Ruhr-University Bochum, Herne, FRG.
Engelmann
U
U
D000818:Animals; D004958:Estradiol / Q000097:blood; D005260:Female; D005934:Glucagon / Q000097:blood; D006728:Hormones / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011167:Portacaval Shunt, Surgical; D011453:Prostaglandins / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013739:Testosterone / Q000097:blood; D014545:Urinary Calculi / Q000097:blood / Q000503:physiopathology*
D006728:Hormones; D011453:Prostaglandins; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005934:Glucagon