title: A biochemical marker for differentiation is present in an in vitro aging cell system.
abstract: In this study it is shown that in an in vitro aging cell system of human diploid fibroblasts the ratio of the histone variants H2A.1/H2A.2 decreases in a linear manner as a function of cumulative population doublings This ratio is known to decrease during differentiation. This finding reinforces the theory that cellular aging is a result of differentiation and programmed cell death rather than degeneration.
authors.affiliation: Institute of Biology, N.R.C. Demokritos, Aghia Paraskevi, Attiki, Greece.
authors.forename: E P
authors.initials: EP
authors.lastname: Rogakou
authors.forename: K E
authors.initials: KE
authors.lastname: Sekeri-Pataryas
mesh_terms: D015415:Biomarkers / Q000032:analysis; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D016922:Cellular Senescence; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D014644:Genetic Variation; D006657:Histones / Q000032:analysis* / Q000235:genetics; D006801:Humans
chemical_list: D015415:Biomarkers; D006657:Histones