Familial subarachnoid hemorrhage in east Finland, 1977-1990.
The familial occurrence of cerebral aneurysms in a defined clinical group of 1150 patients from a defined catchment area was studied. Two or more proven aneurysmal subarachnoid hemorrhage (SAH) patients within the same family were included. Of these 1150 patients, 113 (10%) had a proven familial occurrence of aneurysmal SAH. These 113 patients form 91 SAH families with a total of 203 aneurysm patients. Fifty-four percent of the patients were female, and the mean age in female patients was 49 years and in male patients was 44 years. In 23% of the families, three or more members were identified as having cerebral aneurysms. Middle cerebral artery aneurysms were the most common type (47%). Based on the high incidence (10%) of familial intracranial aneurysms among SAH patients, a prospective study of healthy family members for incidental intracranial aneurysms was performed, with positive findings of 12%.
Ronkainen
A
A
Department of Neurosurgery, University Hospital of Kuopio, Finland.
Hernesniemi
J
J
Ryynänen
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004292:Dominance, Cerebral / Q000235:genetics / Q000502:physiology; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D015996:Survival Rate