Positron emission tomography with fluorine-18-fluorodeoxyglucose for the evaluation of therapeutic isolated regional limb perfusion in a patient with soft-tissue sarcoma.
METHODS
The treatment of a patient with soft-tissue sarcoma was evaluated with FDG-PET. A limb-saving complete remission of a locally advanced liposarcoma of the left thigh was achieved with isolated regional perfusion of the limb with tumor necrosis factor alpha, interferon gamma and melphalan.


RESULTS
PET with 18F-FDG before perfusion showed high glucose consumption in the tumor. After perfusion, glucose metabolism in the tumor was absent. Subsequent excision confirmed complete necrosis of the tumor.


CONCLUSIONS
FDG-PET may be useful in evaluating the results of isolateral regional limb perfusion for soft-tissue sarcomas.
Nieweg
O E
OE
Department of Surgery, University Hospital Groningen, The Netherlands.
Pruim
J
J
Hoekstra
H J
HJ
Paans
A M
AM
Vaalburg
W
W
Oldhoff
J
J
Schraffordt Koops
H
H
D010478:Chemotherapy, Cancer, Regional Perfusion; D003287:Contrast Media; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage; D007866:Leg; D008080:Liposarcoma / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D014055:Tomography, Emission-Computed; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage
D003287:Contrast Media; D014409:Tumor Necrosis Factor-alpha; D019788:Fluorodeoxyglucose F18; D007371:Interferon-gamma; D003847:Deoxyglucose; D008558:Melphalan