title: 205Bi/206Bi cyclotron production from Pb-isotopes for absorption studies in humans.
abstract: Pb(p, xn) thick target excitation functions were measured in the energy range 10-38 MeV in order to optimize the production of isotopically pure radiobismuth from natPb, 206Pb, and 207Pb. Additionally, the decay of Po-isotopes from deuteron irradiation of natural bismuth (209Bi) was exploited for radiobismuth production. 205Bi was produced from 206Pb at 20 MeV with only 2% of 206Bi at 4 weeks post irradiation. Bismuth compounds as used in the treatment of peptic ulcer were labeled with 205Bi for absorption studies in animals and subjects.
authors.affiliation: Abteilung Medizinische Biochemie, Universitätskrankenhaus Eppendorf, Hamburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Fischer
authors.forename: J
authors.initials: J
authors.lastname: Wendel
authors.forename: B
authors.initials: B
authors.lastname: Dresow
authors.forename: V
authors.initials: V
authors.lastname: Bechtold
authors.forename: H C
authors.initials: HC
authors.lastname: Heinrich
mesh_terms: D001729:Bismuth / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D017357:Cyclotrons; D005243:Feces / Q000737:chemistry*; D006801:Humans; D010865:Pilot Projects; D011868:Radioisotopes / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D011868:Radioisotopes; D001729:Bismuth