[Lipid peroxide and free radical scavengers in congenital heart disease with pulmonary hypertension].
There is a strong possibility that lipid peroxide (LPO) exerts a great influence on the persistence of pulmonary vascular obstruction (PVO) after radical operation of congenital heart disease with pulmonary hypertension (PH). We investigated the relationship between LOP and PVO, and discussed the effects of scavengers. Fourteen cases of infantile open heart surgery were investigated. LPO, superoxide dismutase SOD and reduced glutathione (GSH) were measured in blood and lung tissue. In the cases of PH group, the levels of lung tissue and plasma LPO showed significantly higher than those of PS group (p < 0.05) before and after radical operation. The levels of Pp/Ps and pulmonary vascular resistance (PVR) of PH cases showed still higher than those of PS group (p < 0.05) even after radical operation. In addition, the levels of plasma and lung tissue SOD, lung tissue GSH of PH cases were lower than those of PG group. These suggest that LPO plays an important role as the cause of PVO before operation and which remains unchanged even after operation. It is to be expected that increase of the free radical scavengers will be effective to suppress the generation of LPO and at last to reduce the level of PVR after operation.
Asano
M
M
Kariya General Hospital, Japan.
Mishima
A
A
Takeuchi
Y
Y
Usami
S
S
Kotani
H
H
Suzuki
Y
Y
Yura
J
J
D016166:Free Radical Scavengers; D006330:Heart Defects, Congenital / Q000150:complications / Q000378:metabolism*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications*; D008054:Lipid Peroxides / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D013482:Superoxide Dismutase