title: Iodine-123-Tyr-3-octreotide uptake in pancreatic endocrine tumors and in carcinoids in relation to hormonal inhibition by octreotide.
abstract: Uptake of 123I-Tyr-3-octreotide (TOCT) by hormone-secreting abdominal tumors was studied to compare scintigraphic observations with the reduction in hormone levels brought about by a brief therapeutic test.
  
  
  METHODS
  A prospective study was conducted on 17 patients, totalizing 46 proven lesions, with endocrine tumors of the pancreas (10 patients, 20 lesions) and/or carcinoid metastases (8 patients, 26 lesions). Tumor hormonal hypersecretion was inhibited by octreotide.
  
  
  RESULTS
  There was good agreement between the results of these examinations.
  
  
  CONCLUSIONS
  The detection of abdominal tumors using this radiotracer is strongly related to its functional characteristics. Variations in the scintigraphic and test results according to different tumor types were in agreement with published data on the density of somatostatin receptors measured by in vitro studies or scintigraphy and by the therapeutic effects of octreotide.
authors.affiliation: Department of Nuclear Medicine, Hôpital Huriez, CHU de Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Nocaudie-Calzada
authors.forename: D
authors.initials: D
authors.lastname: Huglo
authors.forename: M
authors.initials: M
authors.lastname: Deveaux
authors.forename: B
authors.initials: B
authors.lastname: Carnaille
authors.forename: C
authors.initials: C
authors.lastname: Proye
authors.forename: X
authors.initials: X
authors.lastname: Marchandise
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary; D003951:Diagnostic Errors; D005260:Female; D015408:Gastrinoma / Q000000981:diagnostic imaging / Q000188:drug therapy; D005935:Glucagonoma / Q000000981:diagnostic imaging / Q000188:drug therapy; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D007340:Insulinoma / Q000000981:diagnostic imaging / Q000188:drug therapy; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D011446:Prospective Studies; D011877:Radionuclide Imaging
chemical_list: D006729:Hormones, Ectopic; D007457:Iodine Radioisotopes; C045210:3-Tyr-octreotide; D015282:Octreotide