Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women.
OBJECTIVE
To determine the effects of metformin on blood pressure, left ventricular mass, and some metabolic and endocrine parameters in nondiabetic, obese, hypertensive women.


METHODS
Twelve obese, nondiabetic, hypertensive women received 850 mg metformin 2 times/day for 12 wk and placebo for another 12 wk, according to a double-blind, cross-over, randomized design. All patients were hospitalized 4 times, i.e., before randomization and after each treatment (metformin or placebo), to conduct metabolic and cardiovascular investigations (oral glucose tolerance test, euglycemic clamp associated with indirect calorimetry, and echocardiography).


RESULTS
Fasting glucose, HbA1c, fasting and glucose-stimulated insulin, blood pressure and left ventricular mass, cholesterol, triglycerides, and fibrinogen decreased significantly after metformin treatment, whereas high-density lipoprotein cholesterol increased. The improvement in glucose metabolism resulted from increased sensitivity to insulin.


CONCLUSIONS
These findings suggest that metformin treatment in obese, nondiabetic, hypertensive women produces a more favorable cardiovascular risk profile.
Giugliano
D
D
Department of Gerontology and Metabolic Diseases, Second University of Naples, Italy.
De Rosa
N
N
Di Maro
G
G
Marfella
R
R
Acampora
R
R
Buoninconti
R
R
D'Onofrio
F
F
D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D002151:Calorimetry; D002784:Cholesterol / Q000097:blood*; D004311:Double-Blind Method; D004452:Echocardiography / Q000187:drug effects; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D002784:Cholesterol; D005340:Fibrinogen; D006442:Glycated Hemoglobin; D007328:Insulin; D008687:Metformin; D014280:Triglycerides