[The role of the endothelium-derived relaxing factor in regulating the distensibility of the vessels of the arterial bed].
The inhibiting agent N-nitro-L-arginine was shown to constrict the hindlimb arterial vessels and to decrease their distensibility in the cats with the synthesis of the endothelial relaxing factor. Acetylcholine exerted an opposite effect. The EDRF system seems to have a tonic activity whereas some unrelated factors are involved in the acetylcholine effect.
Syrenskiĭ
A V
AV
Eremeev
V S
VS
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D019335:Nitroarginine; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D000109:Acetylcholine
Izuchenie roli éndotelial'nogo relaksiruiushchego faktora v reguliatsii rastiazhimosti sosudov arterial'nogo rusla.