Blood and hepatic glutathione in linamarin fed rats.
Female Sprague Dawley rats were fed 5 mg linamarin daily for 10 days. Reduced glutathione (GSH) levels in blood and liver of experimental rats were analysed. The results showed an increase of 45% and 33% glutathione levels in blood and liver respectively in experimental rats. This alteration in glutathione levels could be most likely either due to increased hepatic biosynthesis or as a consequence of decreased peripheral utilization which might be appreciated due to hypothyroidal status induced by linamarin feeding.
Uniyal
B P
BP
Institute of Nuclear Medicine & Allied Sciences, Delhi, India.
Singh
L R
LR
Mukherjee
S K
SK
D000818:Animals; D005260:Female; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D007037:Hypothyroidism / Q000209:etiology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D002365:Manihot / Q000633:toxicity; D009570:Nitriles / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009570:Nitriles; D005978:Glutathione; C005091:linamarin