title: Determination of Ki67 growth fraction and oestrogen receptors in screen-detected breast cancer using cytological preparations.
abstract: Oestrogen receptor (ER) status of 77 cases of screen-detected breast cancer has been determined using cytological preparations. In 48% ER status was positive, which was the same proportion as that formed in a control group of age-matched patients with symptomatic breast carcinoma. Since the screen-detected group contained more low grade tumours, the percentage of ER-positive cases would be expected to be higher. The reasons for the discrepancy are discussed. Ki67 score has been determined for 41 cases of screen-detected cancer. Ki67 score showed a positive correlation with histological tumour grade and a negative correlation with ER status. However, there was no correlation with tumour size or lymph node status. The Ki67 scores in the screen-detected cancers were essentially similar to those found in an age-matched symptomatic group, but the very low scores were only found in the screened group.
authors.affiliation: Southampton and Salisbury Breast Screening Unit, Royal South Hants Hospital, UK.
authors.forename: R
authors.initials: R
authors.lastname: Coddington
authors.forename: A
authors.initials: A
authors.lastname: Cuthbert
authors.forename: I D
authors.initials: ID
authors.lastname: Campbell
authors.forename: A
authors.initials: A
authors.lastname: Herbert
authors.forename: J M
authors.initials: JM
authors.lastname: Theaker
authors.forename: G T
authors.initials: GT
authors.lastname: Royle
authors.forename: I
authors.initials: I
authors.lastname: Taylor
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D008403:Mass Screening; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*
chemical_list: D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011960:Receptors, Estrogen