Genetic predisposition and IDDM in Greece.
Serological typing of HLA-DR antigens was performed on 116 patients with IDDM and 380 healthy controls. As expected a high incidence of HLA-DR3 and DR4 antigens was observed in patients with IDDM. However, the HLA-DR2 antigen, which rarely occurs in IDDM and is considered to confer protection against IDDM, was found in equal distribution (35%) in both patients and controls. HLA-DQ genotype analysis in 10 children with IDDM and 13 controls, all with the HLA-DR2 haplotype, showed that the great majority of affected children and normal controls carry the DR2 (16) or AZH-DQA1 *0102, DQB *0502 subtype. The high incidence of this subtype in normal individuals possibly explains why the DR2 antigen does not offer protection against IDDM in Greeks.
Karayanni
C
C
Department of Pediatrics, P. and A. Kyriakou, Children's Hospital, Athens, Greece.
Anastasiadou
V
V
Spyropoulou
M
M
Delis
D
D
Khalil
I
I
Lepage
V
V
Papanicolaoy
M
M
Varla
M
M
Stavropoulou
A
A
Bartsocas
C S
CS
D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D005838:Genotype; D006115:Greece; D006683:HLA-DQ Antigens / Q000097:blood / Q000235:genetics*; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens