Severe flare-up in a prostate cancer patient treated with luteinizing hormone-releasing hormone analogue depot.
A 65-year-old man with advanced prostate cancer was treated with a luteinizing hormone-releasing hormone (LH-RH) analogue. Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up. Chest drainage was required to save his life. Therefore, we emphasize the importance of treatment to prevent tumor flare during LH-RH analogue therapy.
Shimizu
T
T
Department of Urology, Gunma Cancer Center.
Shibata
Y
Y
Uchida
T
T
Satoh
J
J
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D004322:Drainage; D017273:Goserelin / Q000009:adverse effects*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D016066:Pleural Effusion, Malignant / Q000139:chemically induced* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology
D017273:Goserelin