SCH 23390 decreases self-stimulation of the medial prefrontal cortex in the rat.
We studied the effects of peripheral and central administration of SCH 23390, a selective antagonist of dopamine D1 receptors, on intracranial self-stimulation of the medial prefrontal cortex of the rat. Intraperitoneal injections of SCH 23390 produced a dose-related decrease in self-stimulation. Unilateral microinjections of SCH 23390 into the medial prefrontal cortex also produced a dose-related decrease in self-stimulation in the ipsilateral medial prefrontal cortex. However, self-stimulation of the contralateral, noninjected prefrontal cortex, used as control, was not affected. Together with previous data, the present results suggest that the dopamine neurotransmission involved in self-stimulation of the prefrontal cortex of the rat is mediated by dopamine D1 receptors.
Sabater
R
R
Department of Physiology, School of Medicine, University of Granada, Spain.
Saez
J A
JA
Ferrer
J M
JM
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D012653:Self Stimulation / Q000187:drug effects*
D001552:Benzazepines; D017447:Receptors, Dopamine D1