Cytomegalovirus, human herpesvirus 6 and human T cell leukemia virus infection in renal transplanted patients in the northeast of Brazil.
The seroprevalence of antibodies against cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human T cell leukemia virus type 1 (HTLV-1), determined by ELISA and by fluorescence in 54 renal transplanted patients, was 96.2%, 88.8% and 11.1%, respectively. These values are relatively high when compared with the results obtained for healthy individuals of the same age groups from Recife, Northeastern Brazil. Active CMV infection was detected by the presence of IgM antibodies and/or virus isolation in 13 (24%) patients. Kidney rejection and renal dysfunction were observed in 11 of these 13 patients, whereas 3 of 6 HTLV-1 antibody-positive individuals presented these complications. All HTLV-1 positive patients were also positive to IgG CMV and HHV-6 antibodies. The importance of the three viruses in this clinical condition is suggested by the high seropositivity rates compared with the healthy population. The group may also represent a potential source of HTLV-1 infection in this non-endemic area.
Linhares
M I
MI
Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brasil.
Eizuru
Y
Y
Stamford
W P
WP
Andrade
G P
GP
Carvalho Júnior
L B
LB
Minamishima
Y
Y
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D015490:HTLV-I Infections / Q000453:epidemiology*; D006566:Herpesviridae Infections / Q000453:epidemiology*; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D015995:Prevalence
D000914:Antibodies, Viral