Biological activities of terthiophenes and polyynes from the Asteraceae.
We evaluated a number of terthiophenes and polyynes, from the Asteraceae, for biological activities against microorganisms, viruses, and tumor cells, with and without the aid of UVA (long wavelength ultraviolet) radiation. The terthiophenes, which represented the basic alpha-terthienyl nucleus with simple side chains, showed impressive UVA-dependent activities, some of which were superior to alpha-terthienyl itself. In contrast, the polyynes had no significant biological activity, with or without UVA. We believe that these terthiophenes would be worthwhile evaluating in animal models of infectious diseases.
Hudson
J B
JB
Division of Medical Microbiology, University of British Columbia, Vancouver, Canada.
Graham
E A
EA
Rossi
R
R
Carpita
A
A
Neri
D
D
Towers
G H
GH
D000480:Alkynes / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D013876:Thiophenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014780:Viruses / Q000187:drug effects
D000480:Alkynes; D013876:Thiophenes; C019101:alpha-terthienyl