Effects of estradiol on the development of sexual dimorphism in the bed nucleus of the accessory olfactory tract in the rat.
Orchidectomized males injected with a single dose of estradiol benzoate (EB) on the day of birth (D1) showed a volume and neuron number in the nucleus of the accessory olfactory tract (BAOT) similar to that of control males. However, orchidectomized males and those orchidectomized and given a single dose of DHT on D1 showed a decrease in BAOT volume and neuron number with respect to control males. These results support the notion that estradiol induces the morphological masculinization of this structure. The inability of DHT in counteracting the effect of orchidectomy is addressed taking into account the inhibitory action of androgens.
Collado
P
P
Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Ciudad Universitaria, Madrid, Spain.
Valencia
A
A
Del Abril
A
A
Rodríguez-Zafra
M
M
Pérez-Laso
C
C
Segovia
S
S
Guillamón
A
A
D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D009833:Olfactory Pathways / Q000033:anatomy & histology / Q000187:drug effects / Q000254:growth & development*; D009919:Orchiectomy; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics
D013196:Dihydrotestosterone; D004958:Estradiol