Cardiac synovial sarcoma with translocation (X;18) associated with asbestos exposure.
A primary cardiac spindle cell tumor with immunoreactivity for keratin proteins is reported. Cytogenetic analysis of the tumor demonstrated a translocation (X;18), an aberration almost exclusively reported in synovial sarcomas. Postmortem examination revealed amphibole asbestos within the lungs and diaphragmatic pleural plaques indicative of asbestos exposure. These findings raise questions about the possible causation of this tumor.
Karn
C M
CM
Department of Pathology, University of Vermont, Burlington 05405.
Socinski
M A
MA
Fletcher
J A
JA
Corson
J M
JM
Craighead
J E
JE
D000328:Adult; D017639:Asbestos, Amosite; D017636:Asbestos, Amphibole; D002869:Chromosome Aberrations / Q000235:genetics; D002887:Chromosomes, Human, Pair 18; D003964:Diaphragm / Q000473:pathology; D006338:Heart Neoplasms / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D016273:Occupational Exposure; D010994:Pleura / Q000473:pathology; D013584:Sarcoma, Synovial / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic / Q000235:genetics*; D014960:X Chromosome
D017636:Asbestos, Amphibole; D017639:Asbestos, Amosite; C005846:tremolite