Diurnal blood pressure profile in patients with severe congestive heart failure: dippers and non-dippers.
Patients with severe congestive heart failure (CHF) have increased sympathetic nervous activity and altered baroreceptor function, which may influence the diurnal blood pressure rhythm. The 24-h blood pressure profile was measured in 25 patients with severe CHF (mean ejection fraction: 17%) and 25 control subjects. Systemic blood pressure was measured automatically at the arm by a non-invasive blood pressure monitoring system every 15 min. The mean +/- SD systolic blood pressure in CHF patients and controls was during day-time 105 +/- 10 and 130 +/- 11 mm Hg and night-time 97 +/- 10 and 112 +/- 10 mm Hg, i.e. the nocturnal decrease was 9 +/- 6 and 18 +/- 8 mm Hg, respectively (p < 0.0005 for all). The subjects could be divided into two groups: dippers and non-dippers, with and without a relative decrease in nocturnal systolic blood pressure > 10%. There was significantly more non-dipping CHF patients (16) than controls (5) (p < 0.01). Systolic blood pressure was in CHF dippers vs. non-dippers during day-time: 108 +/- 7 vs. 104 +/- 12 mm Hg (NS) and night-time: 92 +/- 7 vs. 99 +/- 11 mm Hg (p = 0.08). The nocturnal decrease was 16 +/- 3 vs. 5 +/- 4 mm Hg and the relative nocturnal decrease 15 +/- 3 vs. 5 +/- 3% (p < 0.00001 for both). It is concluded that patients with severe congestive heart failure can be divided into two groups: dippers and non-dippers, with and without a normal decrease in nocturnal blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Kastrup
J
J
Department of Medicine B, University Hospital, Righospitalet, Copenhagen, Denmark.
Wroblewski
H
H
Sindrup
J
J
Rolighed Christensen
H
H
Wiinberg
N
N
D000328:Adult; D001794:Blood Pressure; D002940:Circadian Rhythm; D006333:Heart Failure / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged