Localization of a gene for Fukuyama type congenital muscular dystrophy to chromosome 9q31-33.
Fukuyama type congenital muscular dystrophy (FCMD) is an autosomal recessive severe muscular dystrophy associated with an anomaly of the brain. Twenty-one FCMD families, 13 of them with consanguineous marriages, were analysed by genetic linkage analyses with polymorphic microsatellite markers to map the FCMD gene. Significant lod scores were obtained with the markers D9S58 (Zmax = 5.81 at theta = 0.06), D9S59 (Zmax = 4.33 at theta = 0.02), and HXB (Zmax = 3.28 at theta = 0.09) on chromosome 9q31-33. Multipoint analysis placed FCMD between D9S58 and D9S59, with a maximum lod score of 16.93. These markers will be useful for presymptomatic, prenatal and carrier diagnosis of family members carrying FCMD, and they represent important resources for the identification of a gene responsible for FCMD.
Toda
T
T
Dept. Biochemistry, Cancer Institute, Tokyo, Japan.
Segawa
M
M
Nomura
Y
Y
Nonaka
I
I
Masuda
K
K
Ishihara
T
T
Sakai
M
M
Tomita
I
I
Origuchi
Y
Y
Suzuki M [corrected to Sakai
M ]
M]
D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D004276:DNA, Satellite; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007564:Japan; D008297:Male; D009136:Muscular Dystrophies / Q000151:congenital / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic
D004276:DNA, Satellite