title: Tardive dyskinesia, lipid peroxidation, and sustained amelioration with vitamin E treatment.
abstract: Plasma levels of thiobarbituric acid reactive substances (TBARS) were measured as an indicator of lipid peroxidation, in 14 patients suffering from tardive dyskinesia (TD). There was a highly significant positive correlation between plasma TBARS (both basal and iron stimulated) and severity of TD. Patients were then treated for 1 month with the free radical scavenger vitamin E (1200 i.u. daily). Following vitamin E treatment, there was a clinically and statistically significant amelioration of TD, and this improvement was maintained at follow-up 7-13 months later. There was no consistent or significant change in plasma TBARS levels related to treatment with vitamin E.
authors.affiliation: Academic Department of Psychiatry, Northern General Hospital, Sheffield, UK.
authors.forename: M
authors.initials: M
authors.lastname: Peet
authors.forename: J
authors.initials: J
authors.lastname: Laugharne
authors.forename: N
authors.initials: N
authors.lastname: Rangarajan
authors.forename: G P
authors.initials: GP
authors.lastname: Reynolds
mesh_terms: D000328:Adult; D000368:Aged; D004409:Dyskinesia, Drug-Induced / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E