title: The prognostic value of nuclear roundness and neopterin in ovarian cancer.
abstract: The prognostic value of clinical factors, morphometric features and neopterin, a marker for macrophage activation, was investigated retrospectively in 68 ovarian carcinoma patients. Nuclear roundness was a good predictor of patient survival. About 50% of our patients showed neopterin concentrations above the cut-off level of 275 mumol/mol creatinine. Interestingly, those patients with elevated urinary neopterin concentration, and thus displaying a sign of activation of cell-mediated immunity, had a shorter survival than those with normal concentration. Applying a multivariate Cox regression analysis, the only independent parameters predicting patient survival were FIGO stage, residual disease, nuclear roundness and neopterin.
authors.affiliation: Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Marth
authors.forename: A
authors.initials: A
authors.lastname: Weger
authors.forename: E
authors.initials: E
authors.lastname: Müller-Holzner
authors.forename: A G
authors.initials: AG
authors.lastname: Zeimet
authors.forename: H
authors.initials: H
authors.lastname: Moncayo-Naveda
authors.forename: G
authors.initials: G
authors.lastname: Daxenbichler
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: H
authors.initials: H
authors.lastname: Wachter
authors.forename: O
authors.initials: O
authors.lastname: Dapunt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D002467:Cell Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008262:Macrophage Activation; D008875:Middle Aged; D019798:Neopterin; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000652:urine; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D001708:Biopterins; D019798:Neopterin