Mechanistic and structural complexity in the site-specific recombination pathways of Int and FLP.
This review focuses on two of the approximately 30 members of the diverse Int family of site-specific recombinases. The lambda recombination system represents those reactions involving accessory proteins and a complex higher-order structure. The FLP system represents the most streamlined reactions and has been the subject of detailed and informative studies on the mechanisms of DNA cleavage and ligation.
Landy
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Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912.
D004254:DNA Nucleotidyltransferases / Q000737:chemistry / Q000235:genetics*; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics*; D019426:Integrases; D011995:Recombination, Genetic; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics*
D005656:Fungal Proteins; D014764:Viral Proteins; D004254:DNA Nucleotidyltransferases; C045119:FLP recombinase; D019426:Integrases