title: [Histoplasmosis of the central nervous system. Clinical aspects in 8 patients].
abstract: Clinical approach has been made in eight patients with histoplasmosis of the central nervous system. All patients had no evidence of immunodepression. Time disease at diagnosis ranged from 6 to 108 months (median 36 months). Main signs and symptoms were: intracranial hypertension in 6 patients; impairment of memory in 4; confusion in 4; seizures in 2; urinary incontinence in 2; sexual impotency in 1. Meningo-encephalitic form was present in 6 patients, while the granulomatous form was found in 2. Diagnostic confirmation was based on: biopsy, in 1 case; necropsy, in 2 cases; cerebrospinal fluid (CSF) sediment culture, in 1; detection of antibodies against Histoplasma capsulatum in the CSF, in 5 cases. There was, in all patients, an expressive difference between CSF alterations (intense, merging acute and chronic phase elements) and clinical symptomatology (patients in general oligosymptomatic).
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Brasil.
authors.forename: L R
authors.initials: LR
authors.lastname: Machado
authors.forename: J P
authors.initials: JP
authors.lastname: Nóbrega
authors.forename: J A
authors.initials: JA
authors.lastname: Livramento
authors.forename: L S
authors.initials: LS
authors.lastname: Vianna
authors.forename: A
authors.initials: A
authors.lastname: Spina-França
mesh_terms: D000293:Adolescent; D000328:Adult; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D002648:Child; D005260:Female; D006660:Histoplasmosis / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged
vernacular_title: Histoplasmose do sistema nervoso central. Aspectos clínicos em oito pacientes.