title: Evaluation of the liver function of cirrhotic patients based on the formation of monoethylglycine xylidide (MEGX) from lidocaine.
abstract: Determination of the functional hepatic reserve is still controversial. Many tests have been proposed, but the assay based on formation of the lidocaine metabolite, monoethylglycine xylidide, seems to offer a promising approach to this problem. In this study we evaluated the effectiveness of the monoethylglycine xylidide test in the clinical evaluation of 31 cirrhotic patients submitted to three different therapeutic options (sclerotherapy, transjugular intrahepatic protosystemic shunt and surgical procedures) and in 1 patient submitted to right hepatectomy for giant hepatic angioma. We found a statistically significant difference between Child A and C patients and between Child B and C patients. The test did not differentiate Child A from Child B patients. We found no correlation between the Child-Pugh score, serum bilirubin, albumin and prothrombin time. There were no differences among the three groups of patients that could be statistically related to their therapy. The monoethylglycine xylidide test seems to be an attractive alternative to previous methods for the evaluation of the functional hepatic reserve, but further studies are necessary to assess the prognostic value of the test in cirrhotics, to separate the independent contribution of portosystemic shunting and hepatocyte dysfunction to monoethylglycine xylidide formation, and to evaluate the test as a prognostic index in cirrhotic patients submitted to general surgery.
authors.affiliation: Laboratorio di Chimica Clinica ed Ematologia, Università degli Studi di Verona, Ospedale Civile Maggiore, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Schinella
authors.forename: A
authors.initials: A
authors.lastname: Guglielmi
authors.forename: G F
authors.initials: GF
authors.lastname: Veraldi
authors.forename: M
authors.initials: M
authors.lastname: Boni
authors.forename: M
authors.initials: M
authors.lastname: Frameglia
authors.forename: M
authors.initials: M
authors.lastname: Caputo
mesh_terms: D000328:Adult; D000368:Aged; D005069:Evaluation Studies as Topic; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000502:physiology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D011170:Portasystemic Shunt, Surgical; D015911:Sclerotherapy
chemical_list: D008012:Lidocaine; C001173:monoethylglycinexylidide