[Lactate dehydrogenase isoenzymes in HIV-positive children].
Considering that in the HIV infection there is a precocious deterioration of humoral immunity with rapid turn-over of cellular B clones, we have evaluated the conduct of serum lactate-dehydrogenase activity (LD, EC 1.1.1.27) and its isoenzymes in 21 children born from HIV-positive mother respect to a control group (30 subjects). Furthermore we have checked the existence of a probable correlation between those and other clinical and immunologic parameters (total lymphocytes, CD4/CD8, immunoglobulins, classification according to the Atlanta CDC). In seropositive children we saw, respect to those evolved towards P3 stage, a significantly raising of LD4 (also vs. control group) for likely pulmonary parenchyma's damage, LD3 for B immature lymphocytes' increase and a reduction of LD1 (also vs. control group) for mature clones' decrement. Furthermore in seropositive subjects there was the existence of a direct correlation between LD1 and CD4/CD8 values. As such, the evaluation of LD isoenzymes can establish an useful element in the clinical monitoring of seropositive children.
Pifferi
M
M
Istituto di Clinica Pediatrica, Università degli Studi di Pisa.
Baldini
M
M
Cappuccio
A
A
Consolini
R
R
Innocenti
B
B
Baldini
G
G
D016516:CD4-CD8 Ratio; D002675:Child, Preschool; D004796:Clinical Enzyme Tests / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000453:epidemiology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007223:Infant; D007527:Isoenzymes; D007558:Italy / Q000453:epidemiology; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D012044:Regression Analysis
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Gli isoenzimi della lattico-deidrogenasi nei bambini HIV-positivi.