Effect of arginine-enriched total parenteral nutrition on the host-tumor interaction in cancer-bearing rats.
By using a transplantable Yoshida sarcoma in a rat total parenteral nutrition model, we measured the effectiveness of an arginine-enriched amino acid solution (AI-82) in terms of leucine kinetics and nitrogen balance as indicators of host-tumor nutrition interaction compared with that of a conventional amino acid solution (Proteamin12). When tumor-bearing rats received isocaloric total parenteral nutrition solutions for 7 days, AI-82 significantly improved host nitrogen balance and significantly decreased the tumor-nitrogen trap throughout the experimental period. Leucine kinetics of whole body and tissues were also determined by a 4-hour continuous infusion of each total parenteral nutrition solution containing 14C-leucine. Significantly increased whole-body leucine oxidation (p < .01) without an increase in leucine release from normal tissues was observed in the AI-82 group. Total incorporation of 14C-leucine into whole muscle was significantly elevated (p < .05) without changes in muscle protein degradation in the AI-82 group. In the whole tumor, AI-82 tended to decrease total incorporation of 14C-leucine, but there was no difference in leucine release caused by protein breakdown between the two groups. These findings suggest that AI-82 can improve the nutritional status of the host over that of the tumor.
Oka
T
T
Section of Biochemistry, Taiho Pharmaceutical Co, Ltd, Tokushima, Japan.
Ohwada
K
K
Nagao
M
M
Kitazato
K
K
D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D007930:Leucine / Q000097:blood / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism; D009752:Nutritional Status; D010289:Parenteral Nutrition, Total; D051381:Rats; D012517:Sarcoma, Yoshida / Q000378:metabolism*
D001120:Arginine; D007930:Leucine; D009584:Nitrogen