title: Optimal delivery of dose in cancer chemotherapy with the support of haematopoietic growth factors.
abstract: The delivery of cancer chemotherapy is often non-optimal because of dose reductions and delays related to various toxic effects. These result in a decrease of the dose intensity as well as of the relative dose intensity of a given regimen compared to a reference protocol. In retrospective studies, such modifications have been shown to negatively influence the therapeutic results in many clinical situations. The ability of haematopoietic growth factors to reduce chemotherapy-related neutropenia and its associated infectious complications allows better dose-on-time delivery of the chemotherapeutic drugs. The potential therapeutic impact of this effect remains to be determined in prospective studies.
authors.affiliation: Hôpital Cardio-Vasculaire, Lyon, France.
authors.forename: V
authors.initials: V
authors.lastname: Trillet-Lenoir
authors.forename: D
authors.initials: D
authors.lastname: Arpin
authors.forename: J
authors.initials: J
authors.lastname: Brune
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D016298:Hematopoietic Cell Growth Factors