title: Nude mouse interim host model for human parathyroid grafts. Part III. Mechanism of modification of allograft antigenicity.
abstract: The alterations of number and DR antigen expression of antigen presenting cells (APCs) in human PTG grafts during the interim hosting period were analyzed. The results were as follows: 1) In C-PTG grafts, the APC number was reduced obviously within 100 days in the interim host. In F-PTG and A-PTG grafts, the APC number was increased at 30 d of interim hosting, and then decreased gradually. 2) No obvious change in D-related (DR) antigen expression of individual APCs was seen in C-PTG and F-PTG grafts. In A-PTG grafts, DR antigen expression was increased at 30 d of interim hosting, but then dropped gradually and asynchronously.
authors.affiliation: PUMC Hospital, CAMS, Beijing.
authors.forename: Z
authors.initials: Z
authors.lastname: Gao
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.forename: W
authors.initials: W
authors.lastname: Tang
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology*; D002452:Cell Count; D006085:Graft Survival / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010280:Parathyroid Glands / Q000276:immunology* / Q000637:transplantation*; D013370:Subrenal Capsule Assay
chemical_list: D006684:HLA-DR Antigens