title: A case-control study on the environmental risk factors of Parkinson's disease in Tianjin, China.
abstract: Using a case-control method, we studied the role of environmental risk factors and viral infection in the development of Parkinson's disease (PD) in China. Ninety-three PD patients and 186 controls were investigated with a questionnaire and from most of them, blood was taken to test the antibody levels of four virus (measles, rubella, HSV-1, CMV) IgG. The study result showed that positive family history, living near rubber plants, drinking river-water were associated with an increased risk of developing PD. In contrast, living in small cities, drinking well-water, drinking hard-liquor frequently, were associated with a decreased risk for PD. PD cases and controls did not differ with respect to other factors investigated including smoking and viral infection. These findings suggest that some environmental factors may be related to the development of PD, but further standardized studies will be required to confirm our results.
authors.affiliation: Department of Neuroepidemiology, Beijing Neurosurgical Institute, P.R. China.
authors.forename: W Z
authors.initials: WZ
authors.lastname: Wang
authors.forename: X H
authors.initials: XH
authors.lastname: Fang
authors.forename: X M
authors.initials: XM
authors.lastname: Cheng
authors.forename: D H
authors.initials: DH
authors.lastname: Jiang
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D004777:Environment; D005260:Female; D006801:Humans; D007221:Industry; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014777:Virus Diseases / Q000150:complications; D014881:Water Supply