title: Interstitial alveolitis as early manifestation of anti-Jo-1 positive polymyositis.
abstract: Polymyositis (PM), dermatomyositis (DM) and inclusion-body myositis belong to a heterogenous group of inflammatory myopathies. Pulmonary manifestations occur in a minority of PM patients due to infiltration of diaphragmatic and thoracic muscles or more rarely due to interstitial lung disease. Here, we report on the case of a 67-year-old patient who developed an interstitial idiopathic alveolitis as an early and rare manifestation of anti-Jo-1-positive polymyositis. Clinical and pathogenetical features of the PM associated interstitial alveolitis are discussed.
authors.affiliation: I Department of Internal Medicine, Johannes-Gutenberg-University, Mainz, FRG.
authors.forename: H F
authors.initials: HF
authors.lastname: Löhr
authors.forename: W O
authors.initials: WO
authors.lastname: Böcher
authors.forename: E
authors.initials: E
authors.lastname: Hermann
authors.forename: J
authors.initials: J
authors.lastname: Müller-Quernheim
authors.forename: H
authors.initials: H
authors.lastname: Schwickert
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer zum Büschenfelde
authors.forename: G
authors.initials: G
authors.lastname: Gerken
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001999:Bronchoscopy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D017285:Polymyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D007166:Immunosuppressive Agents; C046750:Jo-1 antibody