title: Structure of toxic shock syndrome toxin 1.
abstract: The three-dimensional structure of toxic shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus has been determined and refined to an R value of 0.226 for data between 8- and 2.5-A resolution. Overall, the structure of TSST-1 is similar to that of another superantigen, staphylococcal enterotoxin B (SEB). The key differences between these molecules are in the amino termini and in the degree to which a long central helix is covered by surface loops. The region around the carboxyl end of this central helix is proposed to govern the superantigenic properties of TSST-1. An adjacent region along this helix is proposed to be critical in the ability of TSST-1 to induce toxic shock syndrome.
authors.affiliation: Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455.
authors.forename: G S
authors.initials: GS
authors.lastname: Prasad
authors.forename: C A
authors.initials: CA
authors.lastname: Earhart
authors.forename: D L
authors.initials: DL
authors.lastname: Murray
authors.forename: R P
authors.initials: RP
authors.lastname: Novick
authors.forename: P M
authors.initials: PM
authors.lastname: Schlievert
authors.forename: D H
authors.initials: DH
authors.lastname: Ohlendorf
mesh_terms: D000595:Amino Acid Sequence; D000941:Antigens / Q000276:immunology; D001427:Bacterial Toxins; D004768:Enterotoxins / Q000737:chemistry* / Q000276:immunology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D013211:Staphylococcus aureus / Q000737:chemistry*; D018089:Superantigens
chemical_list: D000941:Antigens; D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal