title: Rescue from pediatric ECMO with prolonged hybrid intratracheal pulmonary ventilation. A technique for reducing dead space ventilation and preventing ventilator induced lung injury.
abstract: Hybrid intratracheal pulmonary ventilation (h-ITPV) is a continuous flow ventilatory technique that uses a "reverse thruster" catheter to redirect the flow of gas away from the carina. We report here the use of h-ITPV in a pediatric patient with acute sickle cell chest syndrome who required venoarterial ECMO support because of refractory hypoxemic respiratory failure. Her ECMO course was complicated by air leaks, coagulopathy, cardiac tamponade, and necrotizing tracheobronchitis. She could be weaned from ECMO only by maintaining high pressure conventional ventilatory support. To prevent ventilator induced barotrauma, we initiated h-ITPV and weaned her from ECMO bypass. After 12 days of h-ITPV, with tidal volumes of 2-3 ml/kg at carinal peak inspiratory pressures of 25-30 cm H2O, the air leaks ceased and h-ITPV was discontinued. Dead space ventilation fraction (VD/VT) as low as 0.29 was achieved with this technique. Post-h-ITPV bronchoscopy displayed a dramatic resolution of the necrotizing tracheobronchitis. The patient survived and was discharged from the hospital. We conclude that the use of hybrid ITPV may facilitate weaning from ECMO to low pressure conventional ventilation and prevent the development of pulmonary barotrauma.
authors.affiliation: Division of Critical Care Medicine, Miami Children's Hospital, Florida 33155.
authors.forename: A
authors.initials: A
authors.lastname: Raszynski
authors.forename: K A
authors.initials: KA
authors.lastname: Hultquist
authors.forename: H
authors.initials: H
authors.lastname: Latif
authors.forename: J
authors.initials: J
authors.lastname: Sussmane
authors.forename: M
authors.initials: M
authors.lastname: Soler
authors.forename: A
authors.initials: A
authors.lastname: Alam
authors.forename: J
authors.initials: J
authors.lastname: Brao
authors.forename: J
authors.initials: J
authors.lastname: Amor
authors.forename: D
authors.initials: D
authors.lastname: Kilheeney
authors.forename: T
authors.initials: T
authors.lastname: Kolobow
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000503:physiopathology / Q000628:therapy*; D002248:Carbon Monoxide / Q000097:blood; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D005260:Female; D006801:Humans; D006813:Humidity; D000860:Hypoxia / Q000503:physiopathology / Q000628:therapy*; D007442:Intubation, Intratracheal / Q000295:instrumentation*; D008170:Lung Compliance / Q000502:physiology; D008176:Lung Volume Measurements; D010107:Oxygenators, Membrane; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy*; D015300:Ventilator Weaning; D012122:Ventilators, Mechanical
chemical_list: D002248:Carbon Monoxide