Regulation of Na+,K(+)-ATPase gene expression: a model to study terminal differentiation.
This review focuses on the ontogeny of factors involved in the transcriptional regulation of Na+,K(+)-ATPase expression. The Na+,K(+)-ATPase enzyme is of vital importance for cell function. It is likely that the limited availability of Na+,K(+)-ATPase in infant tissue is the major limiting factor for adaptation to extra-uterine life in several organs. The factors regulating Na+,K(+)-ATPase gene transcription in infancy are discussed. Special emphasis is given to the role of circulating hormones such as glucocorticoids and thyroxine.
Celsi
G
G
Department of Paediatrics, St. Göran's Children's Hospitals, Karolinska Institutet, Stockholm, Sweden.
Wang
Z M
ZM
D000818:Animals; D002454:Cell Differentiation; D015971:Gene Expression Regulation, Enzymologic; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*; D013974:Thyroxine / Q000502:physiology; D014158:Transcription, Genetic
D005938:Glucocorticoids; D000254:Sodium-Potassium-Exchanging ATPase; D013974:Thyroxine