Soft-tissue tumors: diagnosis with Tc-99m (V) dimercaptosuccinic acid scintigraphy.
OBJECTIVE
To assess the potential of technetium-99m (V) dimercaptosuccinic acid (DMSA) scintigraphy for diagnosis of soft-tissue tumors.


METHODS
Tc-99m (V) DMSA scintigraphy was performed in 76 patients with histologic proof of soft-tissue tumors. In 57 of these patients, gallium-67 citrate scintigraphy was performed within 2 weeks after Tc-99m (V) DMSA scintigraphy.


RESULTS
Uptake of Tc-99m (V) DMSA was clearly detected in almost all sarcomas, metastatic carcinomas, highly recurrent benign tumors (ie, extra-abdominal desmoids and tenosynovial giant cell tumors), superficial and deep hemangiomas, and granulomatous soft-tissue lesions but was not found in other benign solid tumors of soft tissue. Uptake of Ga-67 citrate was clearly detected in all inflammatory lesions and metastatic carcinomas, eight of 14 sarcomas (57%), and two of 10 highly recurrent benign tumors (20%) but was not found in hemangiomas or benign soft-tissue tumors.


CONCLUSIONS
Low-grade malignant and highly recurrent benign lesions, which often recur after surgery, were detected more accurately with Tc-99m (V) DMSA scintigraphy than with Ga-67 citrate scintigraphy.
Kobayashi
H
H
Department of Radiology and Nuclear Medicine, Kyoto University, Faculty of Medicine, Japan.
Sakahara
H
H
Hosono
M
M
Shirato
M
M
Endo
K
K
Kotoura
Y
Y
Yamamuro
T
T
Konishi
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D002951:Citrates; D005710:Gallium Radioisotopes; D015609:Organotechnetium Compounds; D019343:Citric Acid; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer