[Use of mathematical models for quantitative environmental health risk assessment].
Two groups of mathematical models used in the quantitative assessment of cancer risk resulting from exposure to chemical substances for identifying a dose-response relationship are presented. They are as follows: statistical and stochastic models or those biologically motivated. Among statistical models, the logit, probit and Weibull models were considered. Among those biologically motivated, a one-hit model was analysed with special reference to they way from assumptions of the carcinogenesis theory to obtaining a dose-response curve. The two remaining models--multi-hit and multi-stage are discussed very briefly. An example of the fitting dose-response curves to experimental data is presented.
Szymczak
W
W
Zakładu Epidemiologii, Instytutu Medycyny Pracy, Lodzi.
Barański
B
B
D000818:Animals; D004781:Environmental Exposure; D004784:Environmental Monitoring; D015386:Hazardous Substances / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D015233:Models, Statistical; D009369:Neoplasms / Q000139:chemically induced*; D012306:Risk; D013269:Stochastic Processes
D015386:Hazardous Substances
Zastosowanie modeli matematycznych w ilościowej ocenie środowiskowego ryzyka zdrowotnego.