title: Validation of an automated method of three-dimensional finite element modelling of bone.
abstract: This study validated an automated method of finite element modelling of bone from CT scan data. After a fresh-frozen cadaveric femur was modelled, strain gauges were attached to the bone at 11 locations and the femur was mechanically tested by applying a load to the femoral head. Linear regression analysis was used to correlate the strains predicted by the model with the experimentally measured strains. The regression results were significant (P < 0.001), indicating that the strain calculated by the FE model is a valid predictor of the measured strain. Verification of the surface strains also supports the validity of the strains and stresses predicted inside the bone. The present study provides a strong rationale for use of this modelling method as a research tool and in possible clinical applications.
authors.affiliation: Rehabilitation Research & Development Service, Department of Veterans Affairs Medical Center, San Francisco, CA.
authors.forename: J H
authors.initials: JH
authors.lastname: Keyak
authors.forename: M G
authors.initials: MG
authors.lastname: Fourkas
authors.forename: J M
authors.initials: JM
authors.lastname: Meagher
authors.forename: H B
authors.initials: HB
authors.lastname: Skinner
mesh_terms: D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003198:Computer Simulation; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D008961:Models, Structural; D012044:Regression Analysis; D013312:Stress, Physiological / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed