title: Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models.
abstract: Tolmetin sodium's efficacy in preventing primary adhesions was evaluated in two adhesion models each in two species: (1) rabbit uterine horn, (2) rat uterine horn, (3) rabbit peritoneal side wall, and (4) rat peritoneal side wall. In each model a single instillation of tolmetin sodium solution into the peritoneal cavity at the time of surgery effectively reduced adhesion formation. This efficacy extended over a wide range of concentrations, volumes, and total dosages, and was similar in rabbits and rats. An aqueous solution of 1 mg/ml tolmetin sodium in 5-15 ml in rabbits and in 3 ml in rats was consistently efficacious in reducing postoperative adhesion formation.
authors.affiliation: Pharmaceutical Research and Development, Ethicon, Inc., Somerville, New Jersey 08876-0151.
authors.forename: E K
authors.initials: EK
authors.lastname: LeGrand
authors.forename: K E
authors.initials: KE
authors.lastname: Rodgers
authors.forename: W
authors.initials: W
authors.lastname: Girgis
authors.forename: K
authors.initials: K
authors.lastname: Struck
authors.forename: J D
authors.initials: JD
authors.lastname: Campeau
authors.forename: G S
authors.initials: GS
authors.lastname: diZerega
authors.forename: T C
authors.initials: TC
authors.lastname: Kiorpes
mesh_terms: D000818:Animals; D005260:Female; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control*; D014046:Tolmetin / Q000008:administration & dosage / Q000627:therapeutic use*; D014591:Uterine Diseases / Q000517:prevention & control*
chemical_list: D014046:Tolmetin