Effects of cardiopulmonary bypass surgery on intravenous ciprofloxacin disposition.
The pharmacokinetic parameters of intravenous ciprofloxacin were examined in five adult male patients on three separate occasions of open heart surgery: the 24 h before cardiopulmonary bypass (CPB) surgery, (PRE), during surgery (SURG), and 48 to 72 h after surgery (POST). Serial blood (n = 16), urine, and SURG tissue samples were collected after intravenous administration of a single 300-mg dose of ciprofloxacin during each study period. All samples were assayed for ciprofloxacin by a specific high-performance liquid chromatographic method. Serum ciprofloxacin concentrations remained constant or continued to decline during the course of CPB surgery. A significant (P < 0.05) decrease in total body clearance was observed during the SURG and POST phases (298 and 306 ml/min/1.73 m2, respectively) compared with that during the PRE phase (364 ml/min/1.73 m2). Renal clearances and elimination half-lives were similar during all three study phases. A nonsignificant decline occurred in the apparent volume of distribution, from mean values of 2.1 and 2.0 liters/kg during the PRE and POST phases, respectively, to 1.7 liters/kg during the SURG phase. The mediastinal fat tissue ciprofloxacin concentrations ranged from 0.45 to 2.89 micrograms/g. Overall, little significant difference was noted in the disposition of intravenous ciprofloxacin during CPB surgery compared with that before and after surgery.
Pryka
R D
RD
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago 60612.
Rodvold
K A
KA
Ting
W
W
Levitsky
S
S
Frost
R W
RW
Lettieri
J T
JT
D000273:Adipose Tissue / Q000378:metabolism; D000368:Aged; D002315:Cardiopulmonary Bypass; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D014018:Tissue Distribution
D002939:Ciprofloxacin