Expression of disodium cromoglygate 'protective' effects observed during V79 cell proliferation.
Disodium cromoglycate (DSCG) in equimolar concentration of 0.56 mumol/l preincubated with an asynchronous cell population decreases the inhibition of proliferation and results in a 100% elimination of inhibition of colony formation induced by benfluron (BF). DSCG protects the cells from unbalanced growth and unbalanced metabolism (e.g., prevention of increase or decrease in protein cell content, glycolytic activity and in amino acid metabolism) which are both the integrating parts of BF cytotoxic reaction. The protective effect of DSCG is manifested also on synchronous cell populations, particularly in G2 phase (26%). DSCG also stabilizes cell membrane by preventing the alterations of its permeability caused by the cytolytic concentrations of benfluron (at a concentration of 1.05 mumol/l and more).
Horáková
K
K
Faculty of Chemical Technology, Slovak Technical University, Bratislava.
Vlcková
A
A
Lukácová
D
D
D000596:Amino Acids / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002999:Clone Cells; D004205:Cromolyn Sodium / Q000494:pharmacology*; D005449:Fluorenes / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D007651:Keto Acids / Q000378:metabolism
D000596:Amino Acids; D000970:Antineoplastic Agents; D005449:Fluorenes; D007651:Keto Acids; D000641:Ammonia; C034234:VUFB 13468; D005947:Glucose; D004205:Cromolyn Sodium