[The adaptive response of B cells to the action of cytotoxic preparations in culture. III. The possible mechanism of the action of adriamycin on immunoglobin synthesis by the cells of murine myeloma].
A dose-dependent stimulation of immunoglobulin synthesis by Spebr-5 cells in the presence of adriamycin is shown. This effect is significantly blocked in the presence of iron-chelating agent 2,2-bipyridine. Moreover, low doses of H2O2 and heat shock also caused enhancement of immunoglobulin synthesis. These data suggest the involvement of free radical processes in the adriamycin induced stimulation of immunoglobulin synthesis.
Meliksetian
M B
MB
Davtian
T K
TK
Ivanova
I V
IV
Aleksanian
Iu T
IuT
Ignatova
T N
TN
D015082:2,2'-Dipyridyl / Q000494:pharmacology; D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D002460:Cell Line; D003545:Cysteine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D004347:Drug Interactions; D004351:Drug Resistance; D004996:Ethidium / Q000037:antagonists & inhibitors; D005978:Glutathione / Q000494:pharmacology; D007136:Immunoglobulins / Q000096:biosynthesis / Q000187:drug effects*; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology / Q000378:metabolism*; D013268:Stimulation, Chemical; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D007136:Immunoglobulins; D015082:2,2'-Dipyridyl; D004317:Doxorubicin; D004996:Ethidium; D005978:Glutathione; D003545:Cysteine
Adaptivnyĭ otvet B-kletok na deĭstvie tsitotoksicheskikh preparatov v kul'ture III. Vozmozhnyĭ mekhanizm vliianiia adriamitsina na sintez immunoglobulinov kletkami myshinoĭ mielomy.