title: Synthesis of 7- and 12-hydroxy- and 7,12-dihydroxy-3-keto-5 beta-cholan-24-oic acids by reduction of 3,7-, 3,12- and 3,7,12-oxo derivatives.
abstract: 7 alpha-, 12 alpha-, 12 beta-Hydroxy and 7 alpha,12 alpha- and 7 alpha,12 beta-dihydroxy-3-ketocholanoic acids were prepared in satisfactory yields protecting the 3-keto group as dimethyl ketal and subsequent reduction with sodium borohydride of the corresponding 7- and 12-oxo functionalities. The same procedure gave also 3,12-diketo-7 alpha-hydroxy-cholanoic acid.
authors.affiliation: Dipartimento di Chimica, Università di Ferrara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fantin
authors.forename: M
authors.initials: M
authors.lastname: Fogagnolo
authors.forename: A
authors.initials: A
authors.lastname: Medici
authors.forename: P
authors.initials: P
authors.lastname: Pedrini
authors.forename: U
authors.initials: U
authors.lastname: Cova
mesh_terms: D001894:Borohydrides; D002793:Cholic Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D001894:Borohydrides; D002793:Cholic Acids; C025364:sodium borohydride; C007036:cholanic acid