Effects of iodate on intraretinal b and c waves of the cat electroretinogram.
In 12 cats, the intravenous and intravitreal administrations of sodium iodate (SI) were performed to examine the effects on b and c waves of electroretinogram in the dark-adapted retina. The intravitreal SI (0.5-3.5 mM) produced the complete suppression of intraretinal b waves without remarkable changes of slow PIII and light-evoked [K+]o decrease in the subretinal space. Intravenous SI (30 mg/kg) also showed the suppression of intraretinal b waves. SI not only acted as a poison to the retinal pigment epithelium but also might block the post-synaptic response.
Yamamoto
F
F
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Kiryu
J
J
Hiroi
K
K
D000818:Animals; D002415:Cats; D003623:Dark Adaptation; D004596:Electroretinography / Q000187:drug effects*; D007275:Injections, Intravenous; D007452:Iodates / Q000494:pharmacology*; D012160:Retina / Q000503:physiopathology*; D014822:Vitreous Body
D007452:Iodates; C032285:sodium iodate