[Pharmacological studies on human urinary kallidinogenase (SK-827): effects on cerebral metabolism].
We investigated the effects of human urinary kallidinogenase (SK-827) on cerebral metabolism in normal and infarcted rabbits. SK-827 did not influence cerebral glucose and oxygen uptake in normal rabbits. In infarcted rabbits, cerebral glucose and oxygen uptake significantly decreased. SK-827 tended to inhibit the decrease of cerebral blood flow, and significantly inhibited the decrease of cerebral glucose and oxygen uptake in infarcted rabbits. Thus, SK-827 improved cerebral glucose metabolism in infarcted rabbits.
Nagano
H
H
Mie Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Japan.
Suzuki
T
T
Tomoguri
T
T
Hayashi
M
M
Tsurumi
K
K
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007610:Kallikreins / Q000494:pharmacology* / Q000652:urine; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits
D007610:Kallikreins; D005947:Glucose