Massive necrotizing pancreatitis in an immunosuppressed renal transplant recipient (successful therapy).
Severe pancreatitis may be associated with massive necrosis of the pancreas and/or retroperitoneal adipose tissue. Toxicity results from the dead tissue and secondary infection. A 45 year old patient, while fully immunosuppressed, developed this complication following cadaveric renal transplantation. He survived continued immunosuppression, 16 operative debridements of the retroperitoneum, and maintained a functioning renal transplant. In view of the previously reported high mortality rates from mild pancreatitis after transplantation, the current experience warrants further evaluation of the open method of treatment.
Slaton
J W
JW
Department of Urology, Medical College of Ohio, Toledo.
Howard
J M
JM
Selman
S H
SH
D000208:Acute Disease; D005921:Glomerulonephritis / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010195:Pancreatitis / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D011182:Postoperative Care; D016896:Treatment Outcome