title: A 3-D radiosurgical methodology for complex arteriovenous malformations.
abstract: A 3-D methodology, the associated targets methodology, for planning radiosurgical irradiations of complex arteriovenous malformations (AVMs) is presented. It uses the ARTEMIS-3D treatment planning system and has been devised and adopted by our group since January 1990. Its main features are: (a) prescription and delivery of a minimal target dose on the surface of the lesion, corresponding to a 60-70% isodose range. The dose to adjacent functional neurological structures is taken into account as well as the maximum dose to the lesion; (b) An optimisation approach consisting of obtaining the optimal superimposition of the isodose surface and the 3-D contour of the lesion and sharp fall-offs by interactive manipulation of the treatment parameters. The clinical choice of the treatment plan is based on a compromise between the optimal reference isodose surface encompassing the lesion and the minimisation of the volumetric dose fall-off. In complex AVMs the angiographic results have been significantly improved in comparison with our previous experience because of the better achieved lesion encompassing.
authors.affiliation: Department of Radiation Oncology, Tenon Hospital, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Lefkopoulos
authors.forename: M
authors.initials: M
authors.lastname: Schlienger
authors.forename: E
authors.initials: E
authors.lastname: Touboul
mesh_terms: D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D010315:Particle Accelerators; D016634:Radiosurgery / Q000379:methods; D013238:Stereotaxic Techniques; D013813:Therapy, Computer-Assisted