title: [Evaluation of the hepatitis B prevention program in newborn infants. II. Amsterdam, 1989-1991].
abstract: OBJECTIVE
  To evaluate the efficiency of the hepatitis B surface antigen (HBsAg) screening programme in pregnant women and the hepatitis B prevention programme in neonates of HBsAg-positive mothers from October 1989 to December 1991.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  Amsterdam Public Health Service, the Netherlands.
  
  
  METHODS
  Analysis of the data routinely collected from pregnant women and neonates of these women and calculation of the protective efficiency of this immunisation programme.
  
  
  RESULTS
  In 1990, 79% and in 1991, 91% of all pregnant women were screened for HBsAg. The overall prevalence was 1.2% in 1990 as in 1991. Of the HBsAg-positive women 96% originated from countries where hepatitis B virus (HBV) is known to be endemic. At the age of ten months all infants had received passive and active immunisation. The anti-HBs titre was 10-50 IU/l in 8 (7%) infants, > 50 IU/l in 94 (88%), 3 were HBsAg-negative with no information on the anti-HBs titre and in 2 HBsAg was present. The protective efficiency of the immunisation schedule was 94% in children born of e-antigen-positive and 93% in children born of e-antigen-negative mothers.
  
  
  CONCLUSIONS
  Active surveillance and intense follow-up are essential in achieving high coverage rates in screening of pregnant women and in immunising neonates of HBsAg-positive mothers.
authors.affiliation: Gemeentelijke Geneeskundige en Gezondheidsdienst, sector Volksgezondheid en Milieu, Amsterdam.
authors.forename: A
authors.initials: A
authors.lastname: Leentvaar-Kuijpers
authors.forename: S
authors.initials: S
authors.lastname: Wiersma
authors.forename: G J
authors.initials: GJ
authors.lastname: van Doornum
authors.forename: R A
authors.initials: RA
authors.lastname: Coutinho
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007115:Immunization Schedule; D007116:Immunization, Passive; D007136:Immunoglobulins; D007231:Infant, Newborn; D009426:Netherlands; D011247:Pregnancy / Q000276:immunology*; D015397:Program Evaluation; D012189:Retrospective Studies; D014505:Urban Population
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D007136:Immunoglobulins; C045213:hepatitis B hyperimmune globulin
vernacular_title: Evaluatie van het hepatitis B-preventieprogramma bij pasgeborenen. II. Amsterdam, 1989-1991.