title: The study of relationships between the damage of visual function and hemorrheology, ocular rheography, as well as other related factors in patients with primary open angle glaucoma (POAG).
abstract: Researches of glaucoma visual function damage, hemorheology, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regression analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic perfusion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platelet adhesion rate. The characteristic of ocular rheographic changes in POAG patients of controlled IOP suggest that the abnormal changes of hemorheology be responsible for the damage of visual function. The abnormal changes of plasma viscosity, blood apparent viscosity, blood viscoelasticity, hematocrit, mean red cell volume etc could be found in addition to the reduction of PO2, SO2% and trace elements (Cr, Zn, Mg, Fe) in patients with POAG. Computed multiply stepwise regression analysis and Bayes discrimination were made among the deteriorate rate of quantitative visual field and 28 factors from the combined investigation. Only the hemorrheological index could be introduced into the multiply regression equations. The more the damage of visual function in POAG patients, the more accurate the discriminatory effect. Based upon the results, and the reports of articles published as well as the search of 1982-1989 Compact Combridge MEDLINE Medical data base, the new clinical concept could be presented that POAG might belong to the scope of blood hyperviscosity syndromes. When IOP elevation and the decrease of ocular artery pressure existed, the damage of visual function in POAG patients should be deteriorated.
authors.affiliation: National Ophthalmological Laboratories, Ministry of Public Health, China.
authors.forename: J
authors.initials: J
authors.lastname: Ge
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: A
authors.initials: A
authors.lastname: Cheng
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
authors.forename: H
authors.initials: H
authors.lastname: Tong
authors.forename: L
authors.initials: L
authors.lastname: Lian
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000328:Adult; D001809:Blood Viscosity; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology; D010992:Plethysmography, Impedance; D014131:Trace Elements / Q000097:blood; D014785:Vision, Ocular / Q000502:physiology*
chemical_list: D014131:Trace Elements