A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers.
From chromosomal region 17q21.3, where a tumour suppressor gene(s) for breast and ovarian cancers is thought to be present, we have isolated a novel gene from a cosmid clone that revealed somatic rearrangements in two breast cancers. The gene (MDC) encodes a 524-amino acid metalloprotease-like, disintegrin-like and cysteine-rich protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions. Rearrangements in both tumours involve multiple exons and disrupt the coding region of the new MDC.
Emi
M
M
Department of Biochemistry, Cancer Institute, Tokyo, Japan.
Katagiri
T
T
Harada
Y
Y
Saito
H
H
Inazawa
J
J
Ito
I
I
Kasumi
F
F
Nakamura
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D002460:Cell Line; D002886:Chromosomes, Human, Pair 17; D018076:DNA, Complementary; D019483:Disintegrins; D015321:Gene Rearrangement; D006801:Humans; D008666:Metalloendopeptidases / Q000235:genetics*; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured; D014688:Venoms / Q000235:genetics*
D018076:DNA, Complementary; D019483:Disintegrins; D010455:Peptides; D014688:Venoms; D008666:Metalloendopeptidases