title: Treatment of advanced primary lung cancer associated with malignant pleural effusion by the combination of immunotherapy and chemotherapy.
abstract: Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were marginal, and the protocol was well-tolerated and feasible. Furthermore, 4 cases were treated with the combination of systemic chemotherapy and adoptive immunotherapy. Of these, 3 cases responded well to the therapy and have shown a complete response for more than 20 months, indicating that adoptive immunotherapy together with chemotherapy might be a beneficial treatment for advanced lung cancer patients.
authors.affiliation: Department of Medicine (II), Niigata University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyao
authors.forename: T
authors.initials: T
authors.lastname: Chou
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Moriyama
authors.forename: S
authors.initials: S
authors.lastname: Mitsuma
authors.forename: M
authors.initials: M
authors.lastname: Wakabayashi
authors.forename: H
authors.initials: H
authors.lastname: Yoshizawa
authors.forename: M
authors.initials: M
authors.lastname: Arakawa
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D017252:CD3 Complex / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000473:pathology / Q000628:therapy*; D002478:Cells, Cultured; D003131:Combined Modality Therapy; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000627:therapeutic use*; D007937:Leukapheresis; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000276:immunology / Q000473:pathology; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D007376:Interleukin-2; D011994:Recombinant Proteins