Mean platelet volume in diabetes mellitus.
We measured mean platelet volume (MPV) in patients with diabetes mellitus, compared with MPV in non-diabetic control subjects. Mean MPV was significantly increased in the diabetic subjects (8.9 +/- 0.07 fL, mean +/- SEM) compared with non-diabetic subjects (8.0 +/- 0.05) (p < 0.001). Since platelet size is a determinant of platelet function, with larger platelets being more reactive per unit volume, we believe platelets may play a part in the micro- and macro-vascular complications of diabetes mellitus.
Sharpe
P C
PC
Department of Clinical Chemistry, Ulster Hospital, Dundonald, Belfast, UK.
Trinick
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D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001792:Blood Platelets / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013997:Time Factors
D001786:Blood Glucose; D006442:Glycated Hemoglobin