Classifying cytostatics on the basis of their angiocidal and angiostatic effects.
This study describes the effects of ten clinically used cytostatics [bleomycin (BLM), cytarabine (Ara-C), cyclophosphamide (CTX), doxorubicin (DOX), etoposide (VP-16), 5-fluorouracil (5-FU), methotrexate (MTX), mitoxantrone (MXN), vincristine (VCR), and vinblastine (VLB)] on the chorioallantoic membrane vessels--especially on vessel counts--and on the weight of the chicken embryo. A significant reduction of vessel counts (VC) due both to angiocidal and an angiostatic action, was induced by DOX, MXN, VP-16, VCR, and VLB. 5-FU and BLM induced only a (weak) angiostatic effect. MTX, Ara-C, and CTX were neither angiocidal nor angiostatic. The classification of cytostatics presented here might have implications for their use in the clinical treatment of malignant tumors.
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Endorphin Research Laboratories, University of Zurich, Switzerland.
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Messiha
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D000482:Allantois / Q000098:blood supply; D000818:Animals; D000970:Antineoplastic Agents / Q000145:classification* / Q000494:pharmacology*; D001808:Blood Vessels / Q000187:drug effects* / Q000196:embryology; D001835:Body Weight / Q000187:drug effects; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply; D004622:Embryo, Mammalian / Q000033:anatomy & histology / Q000187:drug effects; D004625:Embryo, Nonmammalian
D000970:Antineoplastic Agents