[The bronchodilator agent, Ventodisk, in the powdered inhalation form without freon is better].
The authors compared the effectiveness and advantages of the powdered inhalation variety of the preparation Ventodisc (Glaxo) with the "classical" dosed inhalation form of Salbutamol (Polfa) in 21 patients with bronchial asthma. During administration of 0.2 mg of the two drugs various conditions (mastering of the inhalation technique, elimination of the action of other drugs and the same time of day when the drug was administered) was respected. Values of ventilation parameters of the central and peripheral respiratory pathways before administration of the drugs did not differ significantly. The powdered form of salbutamol--Ventodisc (Glaxo) had a greater dilatating action than the classical dosed aerosol form--Salbutamol (Polfa) because: 1. in FEV1 values between rest and Ventodisc (1.47 l and 1.73 l) differed significantly, however, after subsequent inhalation of Salbutamol no further significant improvement occurred (1.79 l); 2. when the sequence of stimuli was reversed a significant increase of the FEV1; value occurred after Salbutamol (from 1.50 l to 1.67 l, p < 0.004) but Ventodisc caused a further significant increase (p < 0.0006). The tolerance of both drugs was equal. The powdered inhalation form of Salbutamol (Ventodisc--Glaxo) was better than the "classical" dosed aerosol form of salbutamol (Salbutamol--Polfa) as it had a greater dilatating effect in the central airways and moreover did not contaminate the environment.
Vondra
V
V
Oddĕlení tuberkulózy a respiracních nemocí FN, Praha.
Reisová
M
M
Malý
M
M
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate / Q000187:drug effects; D008875:Middle Aged; D011208:Powders
D000336:Aerosols; D011208:Powders; D000420:Albuterol
Bezfreonová prásková inhalacní forma bronchodilatancia Ventodisku je výhodnĕjsí.