Tardive dyskinesia, lipid peroxidation, and sustained amelioration with vitamin E treatment.
Plasma levels of thiobarbituric acid reactive substances (TBARS) were measured as an indicator of lipid peroxidation, in 14 patients suffering from tardive dyskinesia (TD). There was a highly significant positive correlation between plasma TBARS (both basal and iron stimulated) and severity of TD. Patients were then treated for 1 month with the free radical scavenger vitamin E (1200 i.u. daily). Following vitamin E treatment, there was a clinically and statistically significant amelioration of TD, and this improvement was maintained at follow-up 7-13 months later. There was no consistent or significant change in plasma TBARS levels related to treatment with vitamin E.
Peet
M
M
Academic Department of Psychiatry, Northern General Hospital, Sheffield, UK.
Laugharne
J
J
Rangarajan
N
N
Reynolds
G P
GP
D000328:Adult; D000368:Aged; D004409:Dyskinesia, Drug-Induced / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E