title: Fast proton spectroscopic imaging of human brain using multiple spin-echoes.
abstract: We introduce a multi-echo multi-slice MR proton spectroscopic imaging method, which allows for a dramatic reduction of the measurement time by acquiring multiple spin-echoes within a single repetition time. In the multi-echo multi-slice experiment discussed in this paper, a threefold reduction in measurement time is obtained by sacrificing some spectral resolution. Signal-to-noise ratio and spatial resolution are preserved. Metabolite images of N-acetyl aspartate, and total choline+total creatine from multiple slices through the human brain are presented and compared with images obtained with a conventional single-echo multi-slice method.
authors.affiliation: Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: J H
authors.initials: JH
authors.lastname: Duyn
authors.forename: C T
authors.initials: CT
authors.lastname: Moonen
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011522:Protons
chemical_list: D011522:Protons