title: Novel internal promoter/enhancer of HTLV-I for Tax expression.
abstract: The transcription initiation signals in retroviruses lie within the long terminal repeat (LTR) sequences. We have found a new transcriptional promoter in a central portion of the genome of human T-cell leukaemia virus type I (HTLV-I). The transcription start site is located just upstream to the ATG codon of the transcriptional trans-activator molecule, tax protein (Tax). The internal promoter may provide a new insight into gene expression of HTLV-I. The mechanism of leukaemogenesis by the defective HTLV-I is also discussed. Furthermore, we have identified two repeats of a novel enhancer sequence AGTTCT, which are located around the initiation site. We call the sequence HIRE (HTLV-I Internal Regulatory Element).
authors.affiliation: Institute for Virus Research, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nosaka
authors.forename: Y
authors.initials: Y
authors.lastname: Ariumi
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: R
authors.initials: R
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Hatanaka
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004279:DNA, Viral; D004742:Enhancer Elements, Genetic; D016356:Gene Products, tax / Q000096:biosynthesis / Q000235:genetics*; D006367:HeLa Cells; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D004279:DNA, Viral; D016356:Gene Products, tax