In vivo binding of radiocesium by two forms of Prussian blue and by ammonium iron hexacyanoferrate (II).
The effect of two forms of Prussian blue, soluble K3 Fe[Fe(CN)6] and insoluble Fe4[Fe(CN)6]3, and of ammonium iron hexacyanoferrate (II) (NH4Fe[Fe(CN)6] on intestinal radiocesium absorption was investigated in rats, pigs, and humans. In rats 5 mg of antidote administered 2 min before 134Cs tracer reduced radiocesium absorption to 2.4-6.3% of the oral dose. In pigs fed with Chernobyl-contaminated whey under normal feeding conditions for a 27 day period, radiocesium activity concentration was reduced from 360 Bq/kg in control animals to 10-30 Bq/kg by 5 g antidote/d. In man 1 g of oral Prussian blue diminished the cesium absorption from a 134Cs-labelled test meal to 5.6-6.4% of the controls. The inhibitory effects of colloidally soluble K3 Fe[Fe(CN)6] and of (NH4Fe[Fe(CN)6] were similar with slightly less inhibition by the insoluble Fe4[Fe(CN)6]3.
Dresow
B
B
Abteilung Medizinische Biochemic, Universitätskrankenhaus Eppendorf, Hamburg, Germany.
Nielsen
P
P
Fischer
R
R
Pfau
A A
AA
Heinrich
H H
HH
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D000931:Antidotes / Q000378:metabolism* / Q000627:therapeutic use; D002586:Cesium / Q000378:metabolism / Q000493:pharmacokinetics* / Q000506:poisoning; D002588:Cesium Radioisotopes; D005260:Female; D005295:Ferrocyanides / Q000737:chemistry* / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013552:Swine
D000931:Antidotes; D002588:Cesium Radioisotopes; D005295:Ferrocyanides; D002586:Cesium; C056252:ammonium iron (III) hexacyanoferrate; C000170:ferric ferrocyanide