title: Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient.
abstract: Human sperm chromosomes from a 46,XY/47,XXY male were obtained using the technique of in vitro penetration of zona-free hamster eggs. The analysis of 543 sperm complements shows a significantly increased incidence (0.9%) of hyperhaploid gonosomal 24,XY sets, with a lack of the expected corresponding gonosomal hypohaploidies, and a normal rate of autosomal non-disjunctions. These results support the suggestion that 47,XXY cells are able to go through meiosis and to form spermatozoa. Only 24,XY sperm chromosomal constitutions were observed suggesting a preferential pairing of homologous sex chromosomes in 47,XXY spermatocytes.
authors.affiliation: Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, France.
authors.forename: J
authors.initials: J
authors.lastname: Cozzi
authors.forename: E
authors.initials: E
authors.lastname: Chevret
authors.forename: S
authors.initials: S
authors.lastname: Rousseaux
authors.forename: R
authors.initials: R
authors.lastname: Pelletier
authors.forename: V
authors.initials: V
authors.lastname: Benitz
authors.forename: H
authors.initials: H
authors.lastname: Jalbert
authors.forename: B
authors.initials: B
authors.lastname: Sèle
mesh_terms: D000328:Adult; D000818:Animals; D006224:Cricetinae; D005260:Female; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000235:genetics*; D008297:Male; D009030:Mosaicism; D013084:Sperm-Ovum Interactions; D013091:Spermatogenesis; D013094:Spermatozoa / Q000166:cytology*; D014960:X Chromosome; D014998:Y Chromosome