Successful allogeneic bone marrow transplantation in an adult with aplastic anemia following orthotopic liver transplantation for non-A, non-B, non-C hepatitis.
A 29-year-old male patient presented with acute liver failure from non-A, non-B and non-C hepatitis, necessitating orthotopic liver transplantation. After operation he developed progressive pancytopenia on the basis of aplastic anemia, which was probably hepatitis associated. After therapy with GM-CSF had failed, he underwent allogeneic BMT from his HLA genotypically identical brother following a conditioning regimen of CY 50 mg/kg x 4 and 500 cGy total lymphoid irradiation. He engrafted promptly but transfusion dependency did not resolve until CMV viremia was treated with ganciclovir. The patient is alive and well 2 years after BMT.
Dugan
M J
MJ
Department of Medical Education, Methodist Hospital, Indianapolis, IN 46206-1367.
Rouch
D A
DA
Akard
L P
LP
Sperl
B G
BG
Black
J R
JR
Markham
R E
RE
Jansen
J
J
D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D016465:Bone Marrow Purging; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy; D004351:Drug Resistance; D015774:Ganciclovir / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications* / Q000601:surgery; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D016031:Liver Transplantation; D015182:Lymphatic Irradiation; D008297:Male; D011183:Postoperative Complications; D014766:Viremia / Q000188:drug therapy / Q000382:microbiology
D007155:Immunologic Factors; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003520:Cyclophosphamide; D015774:Ganciclovir