Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state.
The interactions of dicarboxylic porphyrins with membrane systems are discussed with particular emphasis on the effect of the charge of the porphyrin and the nature of the side-chains. The incorporation of hematoporphyrin or related dicarboxylic porphyrins within small unilamellar vesicles as membrane models is favored by a decrease of the pH in the range of physiological pH values. This effect might play an important role in the retention of porphyrins by tumors, which are more acidic than normal tissues. Kinetics studies also show that the partition of the porphyrin between the lipidic bilayer and the aqueous phase is governed by its release rate rather than by its incorporation rate.
Brault
D
D
Laboratoire de Biophysique, INSERM U.201, CNRS UA 481, Muséum National d'Histoire Naturelle, Paris, France.
Vever-Bizet
C
C
Kuzelova
K
K
D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry*; D006415:Hematoporphyrins / Q000737:chemistry; D007477:Ions; D008566:Membranes / Q000737:chemistry*; D008567:Membranes, Artificial; D011166:Porphyrins / Q000737:chemistry*
D002264:Carboxylic Acids; D006415:Hematoporphyrins; D007477:Ions; D008567:Membranes, Artificial; D011166:Porphyrins