[Analgesic effect and gastro-intestinal motility inhibitory action of 3-hydroxy-4-methoxy-acetophenone from Cynanchum paniculatum (Bunge) Kitagawa].
3-Hydroxy-4-methoxy-acetophenone (HMA) isolated from Cynanchum paniculatum was found to have analgesic effect and inhibitory action on the gastro-intestinal motility. The effect and action were equivalent to that of paeonol, HMA displayed a very low degree of antibacterial activity against Escherichia coli and Shigella flexneri.
Sun
F Z
FZ
Nanjing Institute of Materia Medica.
Cai
M
M
Lou
F C
FC
D000098:Acetophenones / Q000302:isolation & purification / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects*; D012763:Shigella flexneri / Q000187:drug effects
D000098:Acetophenones; D000700:Analgesics; D004365:Drugs, Chinese Herbal; C085119:3-hydroxy-4-methoxyacetophenone; C013638:paeonol