[The intensification of nitric oxide synthesis in the aortic wall in experimental myocardial infarct].
The effect of experimental myocardial infarction on endothelium-dependent relaxation of isolated rat aorta and generation of nitric oxide in the aortic wall was studied. Three hours following myocardial infarction, the endothelium-dependent relaxation induced with acetylcholine was increased to 61 +/- 2% as compared with 41 +/- 4% in control (r < 0.05). The nitric oxide generation (EPR-assay) was 2.5 times increased in the aortic wall of animals subjected to myocardial infarction as compared with the control. The activated generation of nitric oxide may be provoked by the reduced minute volume of the heart and concomitant transient hypovolemia.
Vanin
A F
AF
Manukhina
E B
EB
Lapshin
A V
AV
Meerson
F Z
FZ
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D004050:Ditiocarb / Q000031:analogs & derivatives / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005296:Ferrous Compounds / Q000494:pharmacology; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000503:physiopathology; D009569:Nitric Oxide / Q000032:analysis / Q000096:biosynthesis*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology
D005296:Ferrous Compounds; C085124:diethyldithiocarbamate iron(II); D009569:Nitric Oxide; D004050:Ditiocarb; D000109:Acetylcholine; D009638:Norepinephrine
Usilie sinteza oksida azote v stenke aorty pri éksperimental'nom infarkte miokarda.