title: Application of magnetic resonance imaging and three-dimensional treatment planning in the treatment of orbital lymphoma.
abstract: Radiotherapy for lymphoma of the orbit must be individualized for each patient and clinical setting. Most techniques focus on optimizing the dose to the tumor while sparing the lens. This study describes a technique utilizing magnetic resonance imaging (MRI) and three dimensional (3D) planning in the treatment of orbital lymphoma. A patient presented with an intermediate grade lymphoma of the right orbit. The prescribed tumor dose was 4050 cGy in 18 fractions. Three D planning was carried out and tumor volumes, retina, and lens were subsequently outlined. Dose calculations including dose volume histograms of the target, retina, and lens were then performed. Part of the retina was outside of the treatment volume while 50% of the retina received 90% or more of the prescribed dose. The patient was clinically NED when last seen 2 years following therapy with no treatment-related morbidity. Patients with lymphomas of the orbit can be optimally treated using MRI based 3D treatment planning.
authors.affiliation: Department of Radiation Oncology and Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
authors.forename: M S
authors.initials: MS
authors.lastname: Rudoltz
authors.forename: K
authors.initials: K
authors.lastname: Ayyangar
authors.forename: M
authors.initials: M
authors.lastname: Mohiuddin
mesh_terms: D000368:Aged; D000465:Algorithms; D003196:Computer Graphics / Q000295:instrumentation; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000473:pathology / Q000528:radiation effects; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009915:Orbit / Q000473:pathology / Q000528:radiation effects; D009918:Orbital Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation*; D012160:Retina / Q000473:pathology / Q000528:radiation effects