The prognostic value of nuclear roundness and neopterin in ovarian cancer.
The prognostic value of clinical factors, morphometric features and neopterin, a marker for macrophage activation, was investigated retrospectively in 68 ovarian carcinoma patients. Nuclear roundness was a good predictor of patient survival. About 50% of our patients showed neopterin concentrations above the cut-off level of 275 mumol/mol creatinine. Interestingly, those patients with elevated urinary neopterin concentration, and thus displaying a sign of activation of cell-mediated immunity, had a shorter survival than those with normal concentration. Applying a multivariate Cox regression analysis, the only independent parameters predicting patient survival were FIGO stage, residual disease, nuclear roundness and neopterin.
Marth
C
C
Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria.
Weger
A
A
Müller-Holzner
E
E
Zeimet
A G
AG
Moncayo-Naveda
H
H
Daxenbichler
G
G
Reibnegger
G
G
Fuchs
D
D
Wachter
H
H
Dapunt
O
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D002467:Cell Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008262:Macrophage Activation; D008875:Middle Aged; D019798:Neopterin; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000652:urine; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis
D001708:Biopterins; D019798:Neopterin