[The effects of cimetidine on splanchnic hemodynamics in cirrhotic patients with portal hypertension].
The effects of histamine H2-receptor antagonist cimetidine on the splanchnic hemodynamics were investigated in 24 cirrhotic patients with portal hypertension and on cardiac output (CO) in 12 of the 24 patients. Cimetidine given intravenously at a dose of 0.4g significantly decreased wedged hepatic venous pressure (-19%, P < 0.01) and hepatic venous pressure gradient (-29%, P < 0.01). The drug also slightly increased left ventricular ejection fraction (+4.1%, P < 0.01). These results show that cimetidine effectively reduce portal venous pressure and not hinder the pump function of the heart.
Li
S
S
People's Hospital, Beijing Medical University.
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy* / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013152:Splanchnic Circulation / Q000187:drug effects*
D002927:Cimetidine