title: [Pediatric liver transplantation and related live donor. Technical and ethical considerations].
abstract: With improved results of liver transplantation, the number of candidates is increasing. However the scarcity of suitable grafts from cadaveric donors remains a limitation. In spite of the use of full size or reduced size grafts or partial grafts from split livers, some children still die while waiting for liver transplantation. We describe a successful orthotopic liver transplantation in a 10 months old female using the left lateral lobe (segments II and III) from her 27 years old father. The child suffered from biliary atresia, her condition was deteriorating with intractable ascites and increasing jaundice. The father asked us to give a part of his own liver to his daughter. The concept of this innovative therapy had already been submitted to a research-ethics consultation which gave us favorable conclusions. After careful donor evaluation, the left lateral lobe was harvested on July 22, 1992, including the left hepatic artery, left portal vein and left hepatic vein; hepatic artery for segment IV, which arose from the right structures, was preserved, The graft was immediately transplanted orthotopically after recipient total hepatectomy with inferior vena cava preservation. Cold ischemia time was 1 hour and 45 minutes, revascularization of the graft was homogeneous from the very beginning and its early function was excellent. Thirteen days after the operation, the donor was discharged in good condition. The child was reoperated at day 9 for a small biliary leak originating from the cut surface of the liver. After resolution of an episode of rejection and an intra-abdominal abscess, the child was discharged in good health with normal liver function 1 month post-transplant.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Unité de Transplantation Hépatique, Hôpital Edouard Herriot, Lyon.
authors.forename: O
authors.initials: O
authors.lastname: Boillot
authors.forename: M
authors.initials: M
authors.lastname: Dawahra
authors.forename: J
authors.initials: J
authors.lastname: Porcheron
authors.forename: D
authors.initials: D
authors.lastname: Houssin
authors.forename: C
authors.initials: C
authors.lastname: Boucaud
authors.forename: D
authors.initials: D
authors.lastname: Gille
authors.forename: C
authors.initials: C
authors.lastname: Kopp
authors.forename: D
authors.initials: D
authors.lastname: Bodnar
authors.forename: L
authors.initials: L
authors.lastname: Sann
authors.forename: P
authors.initials: P
authors.lastname: Paliard
mesh_terms: D000328:Adult; D000792:Angiography; D001656:Biliary Atresia / Q000000981:diagnostic imaging / Q000601:surgery*; D004992:Ethics, Medical; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007223:Infant; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D010290:Parents; D011182:Postoperative Care; D011300:Preoperative Care; D014019:Tissue Donors; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
vernacular_title: Transplantation hépatique pédiatrique et donneur vivant apparenté. Considérations techniques et éthiques.