title: Carbamazepine toxicity resulting from generic substitution.
abstract: Generic substitution is practiced widely in both hospital and community settings. There have been several reports of reduced serum concentrations and seizure exacerbation following generic substitution of Tegretol. We describe the first 2 cases of carbamazepine toxicity resulting from the substitution of Tegretol with Epitol. Two 6-year-old children experienced increases in the maximum serum carbamazepine concentration, one of 22% and one of 41%. Both became asymptomatic when their serum concentrations were lowered and had no residual effects.
authors.affiliation: Department of Neuroscience, Miami Children's Hospital, FL 33155.
authors.forename: J T
authors.initials: JT
authors.lastname: Gilman
authors.forename: L A
authors.initials: LA
authors.lastname: Alvarez
authors.forename: M
authors.initials: M
authors.lastname: Duchowny
mesh_terms: D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002648:Child; D016568:Drugs, Generic / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D012640:Seizures / Q000097:blood / Q000188:drug therapy
chemical_list: D016568:Drugs, Generic; D002220:Carbamazepine