title: Spatio-temporal progression of the AEP P300 component using the cortical imaging technique.
abstract: The cortical imaging technique (CIT), a mathematical method for simulating the potential fields on the surface of the brain, was used to analyze the spatio-temporal progression of the AEP P300 component (as well as the preceding and subsequent N2a and N3 components) from thirty normal adult subjects recorded in a standard "oddball" paradigm. Comparisons were made between the progressions of the endogenous event-related cognitive potentials and the exogenous stimulus-dependent potentials (N1 component). Cortical imaging results suggest that different and multiple generator sites are involved in the production of exogenous and endogenous evoked responses. We particularly note the asymmetric development of the P300 component and the apparent anterior generator sites for the N2a component. This last result is interesting because the N2a precedes the P300 component and supports an earlier frontal contribution.
authors.affiliation: Department of Electrophysiology, Institute of Living, Hartford, CT.
authors.forename: M R
authors.initials: MR
authors.lastname: Ford
authors.forename: R D
authors.initials: RD
authors.lastname: Sidman
authors.forename: G
authors.initials: G
authors.lastname: Ramsey
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006801:Humans; D013997:Time Factors