Hemarthrosis and synovitis associated with hemophilia: clinical use of P-32 chromic phosphate synoviorthesis for treatment.
OBJECTIVE
To evaluate the clinical usefulness of phosphorus-32 chromic phosphate synoviorthesis in patients with hemophilia, recurrent hemarthrosis, and synovitis.


METHODS
Forty-four P-32 colloid synoviorthesis procedures were performed in 38 patients with these abnormalities. P-32 colloid was injected intramuscularly in a dose of 1.0 mCi (37.0 MBq) in adult knees and 0.5 mCi (18.5 MBq) in adult elbows. A thin-window Geiger-Müller counter was used to survey treated joints, lymph nodes, and liver in order to detect leakage from the joint. Follow-up extended to a maximum of 4 years after treatment.


RESULTS
No evidence of clinically significant leakage was seen. Twenty-two of 28 treatments (78%) with longer than 6 months follow-up were associated with improvement in range of motion and frequency of hemorrhage. Of 15 treatments with longer than 2 years follow-up, 10 (67%) were associated with improvement in range of motion; 12 (80%), with improvement in frequency of hemorrhage; and 12 (80%) with improvement in quality-of-life activities.


CONCLUSIONS
P-32 colloid synoviorthesis is a clinically useful out-patient procedure in patients with hemophilia, recurrent hemarthrosis, and synovitis in whom hemostatic therapy has failed.
Siegel
H J
HJ
New York University School of Medicine, NY.
Luck
J V
JV
Siegel
M E
ME
Quines
C
C
Anderson
E
E
D000293:Adolescent; D000328:Adult; D002648:Child; D017608:Chromium Compounds / Q000008:administration & dosage*; D003102:Colloids; D005500:Follow-Up Studies; D006395:Hemarthrosis / Q000209:etiology / Q000532:radiotherapy*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007270:Injections, Intra-Articular; D008875:Middle Aged; D010710:Phosphates / Q000008:administration & dosage*; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage*; D012008:Recurrence; D013583:Synovial Membrane / Q000528:radiation effects; D013585:Synovitis / Q000209:etiology / Q000532:radiotherapy*
D017608:Chromium Compounds; D003102:Colloids; D010710:Phosphates; D010761:Phosphorus Radioisotopes; C509369:chromic phosphate