Characteristics and possible function of endoglin, a TGF-beta binding protein.
Endoglin was recently described as a major TGF-beta binding protein on endothelial cells. In this review we summarize the experimental data on this molecule, discuss some of our own findings, and speculate on its function.
Westphal
J R
JR
University Hospital Nijmegen, Dept. Pathology, The Netherlands.
Willems
H W
HW
Schalkwijk
C J
CJ
Ruiter
D J
DJ
De Waal
R M
RM
D000818:Animals; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000071063:Endoglin; D004727:Endothelium / Q000378:metabolism / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis / Q000096:biosynthesis / Q000502:physiology*; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta; D019010:Vascular Cell Adhesion Molecule-1