title: Silicone breast implant ruptures in an animal model: comparison of mammography, MR imaging, US, and CT.
abstract: OBJECTIVE
  To determine the most accurate imaging modality for detection of silicone implant ruptures.
  
  
  METHODS
  Forty single-lumen silicone implants were surgically placed in 20 rabbits. Each rabbit received one intact and one ruptured implant and was examined with mammography, magnetic resonance (MR) imaging, ultrasound (US), and computed tomography (CT). Five radiologists reviewed all images in a random fashion and graded each for rupture. The radiologist who performed US also graded her impression during examination with US. Receiver operating characteristic (ROC) analysis was performed.
  
  
  RESULTS
  MR imaging and CT were the most accurate modalities in detection of implant ruptures, with areas under the ROC curves (Az) of .95 and .91. Mammography and US were statistically significantly inferior, with Az of .77 for each (P < .05).
  
  
  CONCLUSIONS
  MR imaging and CT are statistically more accurate than US and mammography for detection of intracapsular silicone implant ruptures when only the images are reviewed.
authors.affiliation: Iris Cantor Center for Breast Imaging, Department of Radiological Sciences, School of Medicine, University of California, Los Angeles.
authors.forename: D P
authors.initials: DP
authors.lastname: Gorczyca
authors.forename: N D
authors.initials: ND
authors.lastname: DeBruhl
authors.forename: C Y
authors.initials: CY
authors.lastname: Ahn
authors.forename: A
authors.initials: A
authors.lastname: Hoyt
authors.forename: J W
authors.initials: JW
authors.lastname: Sayre
authors.forename: P
authors.initials: P
authors.lastname: Nudell
authors.forename: M
authors.initials: M
authors.lastname: McCombs
authors.forename: W W
authors.initials: WW
authors.lastname: Shaw
authors.forename: L W
authors.initials: LW
authors.lastname: Bassett
mesh_terms: D000818:Animals; D001940:Breast; D003952:Diagnostic Imaging; D008279:Magnetic Resonance Imaging; D008327:Mammography; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D012372:ROC Curve; D011817:Rabbits; D012828:Silicones; D014057:Tomography, X-Ray Computed; D016217:Ultrasonography, Mammary
chemical_list: D012828:Silicones