Nature of elevated blood pressure in normoalbuminuric type I diabetic patients. Essential hypertension?
This study was undertaken to characterize type I diabetic patients with essential hypertension with respect to kidney function, renal hormones, and endothelial function. After 4 weeks without antihypertensive treatment, a cross-sectional study was carried out in the following groups: group 1, 14 healthy controls; group 2, 13 nondiabetic patients with essential hypertension (blood pressure > or = 140/90 mm Hg); group 3, 11 type I diabetic patients with hypertension but urinary albumin excretion (UAE) persistently normal (UAE: 10 mg/24 h, range 3 to 18) both before, during, and after discontinuing antihypertensive treatment; group 4, 15 type I diabetic patients with clinical nephropathy (UAE: 611 mg/24 h, range 192 to 3837) and hypertension. Systolic and diastolic blood pressures were similar in the three hypertensive groups: 147/96 +/- 8/6, 150/94 +/- 11/9, and 152/92 +/- 12/6 mm Hg (groups 2, 3, and 4, respectively) but elevated compared with controls (114/74 +/- 9/9 mm Hg, P < .001). The diabetic patients with essential hypertension were hyperfiltering in contrast to patients with nephropathy (glomerular filtration rate 114 +/- 23 v 90 +/- 21 mL/min/173 m2, P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
Nørgaard
K
K
Steno Diabetes Center, Gentofte, Denmark.
Rasmussen
E
E
Jensen
T
T
Giese
J
J
Feldt-Rasmussen
B
B
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000209:etiology; D000450:Aldosterone / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000209:etiology; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000378:metabolism
D001786:Blood Glucose; D008074:Lipoproteins; D000450:Aldosterone; D012964:Sodium