title: Primary nasal melanoma with exclusive liver metastasis: a case report.
abstract: A 50-year-old male presented with a nasal mass causing obstruction and bleeding. The initial biopsy indicated a malignant lymphoma but the subsequent biopsy diagnosed an undifferentiated carcinoma. However, histopathological study and immunohistochemical study, made a final diagnosis of nasal melanoma. Six months after the diagnosis, the patient developed exclusive liver metastasis. He responded to 1 course of intensive chemotherapy with 200 mg/m2 cisplatin and 5000 mg/m2 dacarbazine for 6 months. For patients with nasal cavity malignancy, the possibility of primary melanoma should be considered. Combination chemotherapy with intensive dose of cisplatin and dacarbazine may be a viable treatment regimen for nasal melanoma with liver metastasis.
authors.affiliation: Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: T J
authors.initials: TJ
authors.lastname: Chiou
authors.forename: L S
authors.initials: LS
authors.lastname: Chen
authors.forename: S L
authors.initials: SL
authors.lastname: Lin
authors.forename: P M
authors.initials: PM
authors.lastname: Chen
mesh_terms: D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology* / Q000628:therapy