title: Blood loss during repair of craniosynostosis.
abstract: Surgical repair of craniosynostosis carries a high risk with large blood losses. Over a 2-yr period, we have managed 115 patients undergoing craniosynostosis repair with peroperative haemodilution to achieve a final PCV of 0.28-0.35. Measurements of PCV allowed calculation of estimated blood losses and transfused volumes in terms of red blood cell mass. Total estimated red cell volume lost was 91 +/- 66% of patient's estimated red blood cell volume during the peroperative period. The type of skull deformation and surgical procedure determined the extent of peroperative bleeding. Peroperative transfusion was satisfactory in 48% of patients and slight overtransfusion was noted in 32%. During the postoperative period, liberal administration of blood led to overtransfusion and possibly unnecessary transfusion in 74% of patients. Because of the well known risks of transmission of infectious disease, strict volume compensation with development of haemodilution and autotransfusion procedures should be used to limit these risks.
authors.affiliation: Department of Paediatric Anaesthesiology, Hôpital des Enfants-Malades, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.forename: D
authors.initials: D
authors.lastname: Renier
authors.forename: E
authors.initials: E
authors.lastname: Arnaud
authors.forename: M M
authors.initials: MM
authors.lastname: Jarreau
authors.forename: B
authors.initials: B
authors.lastname: Charron
authors.forename: E
authors.initials: E
authors.lastname: Buy
authors.forename: C
authors.initials: C
authors.lastname: Buisson
authors.forename: G
authors.initials: G
authors.lastname: Barrier
mesh_terms: D000367:Age Factors; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D003398:Craniosynostoses / Q000097:blood / Q000601:surgery*; D004911:Erythrocyte Volume; D005147:Facial Bones / Q000601:surgery; D006400:Hematocrit; D006801:Humans; D007223:Infant; D012886:Skull / Q000601:surgery*