(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.
Gaster
L M
LM
SmithKline Beecham Pharmaceuticals, Harlow, Essex, England.
Jennings
A J
AJ
Joiner
G F
GF
King
F D
FD
Mulholland
K R
KR
Rahman
S K
SK
Starr
S
S
Wyman
P A
PA
Wardle
K A
KA
Ellis
E S
ES
D000818:Animals; D004146:Dioxanes / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D008787:Metoclopramide / Q000031:analogs & derivatives; D009119:Muscle Contraction / Q000187:drug effects; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004146:Dioxanes; D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C084858:SB 204070A; D008787:Metoclopramide