title: A comparative burn wound model in the New Yorkshire pig for the histopathological evaluation of local therapeutic regimens: silver sulfadiazine cream as a standard.
abstract: A standard burn wound model was developed in the pig to enable evaluation of histopathological parameters of wound healing under different circumstances. Wounds on one flank were treated with silver sulfadiazine 1% cream (SSD, Flammazine-Duphar), which is a standard treatment. On identical places of the contralateral side different topical agents were applied. From the SSD treated burns a typical histopathologic picture of wound healing under SSD could be derived: SSD has the potential to preserve viable dermal tissue, epidermal regeneration is rather slow and irritated, while the formation of granulation tissue is pronounced, with an abundance of myofibroblasts.
authors.affiliation: Burns Unit, Red Cross Hospital, Beverwijk, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hoekstra
authors.forename: P
authors.initials: P
authors.lastname: Hupkens
authors.forename: R P
authors.initials: RP
authors.lastname: Dutrieux
authors.forename: M M
authors.initials: MM
authors.lastname: Bosch
authors.forename: T A
authors.initials: TA
authors.lastname: Brans
authors.forename: R W
authors.initials: RW
authors.lastname: Kreis
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D006097:Granulation Tissue / Q000473:pathology; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D013552:Swine; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
chemical_list: D012837:Silver Sulfadiazine