Cutaneous hypersensitivity to co-trimoxazole after autologus bone marrow transplantation and immunotherapy with interferon alpha-2A and interleukin-2.
Typical cutaneous hypersensitivity reaction to co-trimoxazole was seen in a woman after autologous bone marrow transplantation and immunotherapy. She had developed no such reaction during chemotherapy prior to the transplant or immediately after the transplant. The immunoperturbed state that exists for a period of time after bone marrow transplantation, especially in the presence of immunomodulation caused by combined therapy with recombinant human interferon alpha and interleukin-2, with exposure to potentially reaginic agents may have contributed to the development of the hypersensitivity reaction in this patient.
Mehta
J
J
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Nagler
A
A
Ackerstein
A
A
Kapelushnik
J
J
Or
R
R
D000328:Adult; D016026:Bone Marrow Transplantation; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000276:immunology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D016898:Interferon-alpha; D007376:Interleukin-2; D015662:Trimethoprim, Sulfamethoxazole Drug Combination