title: An approach to the determination of endotoxin in anesthetics and antibiotics: use of an ultrafiltration system and enzymatic LAL reaction.
abstract: An ultrafiltration system is used to obtain an endotoxin-free buffer for the LAL test. The procedure is combined with a kinetic LAL reaction of high sensitivity. This approach allows for the easy determination of endotoxin levels in parenterals with LAL-interfering substances, reducing the maximum valid dilution necessary for use in product development.
authors.forename: H
authors.initials: H
authors.lastname: Justicia
authors.forename: M
authors.initials: M
authors.lastname: Ibañez
mesh_terms: D000777:Anesthetics / Q000032:analysis*; D000900:Anti-Bacterial Agents / Q000032:analysis*; D004731:Endotoxins / Q000032:analysis*; D008033:Limulus Test; D010288:Parenteral Nutrition; D014462:Ultrafiltration
chemical_list: D000777:Anesthetics; D000900:Anti-Bacterial Agents; D004731:Endotoxins