Immunohistochemical expression of carbohydrate antigen 19-9 in colorectal carcinoma.
OBJECTIVE
Carbohydrate antigen 19-9 (CA19-9) is one of the most representative tumor markers in colorectal carcinomas. We studied the immunohistochemical expression of CA19-9 in primary colorectal carcinoma to identify its significance as a prognostic factor.


METHODS
The avidin-biotin-peroxidase complex method was used for CA19-9 staining in sections from 149 patients with primary colorectal carcinoma. The data were studied by univariate and multivariate analyses.


RESULTS
86 tumors (56%) stained positively. The staining pattern was classified into three groups: group I (a stromal type, 22 tumors), group II (an apical and/or cytoplasmic type, 64 tumors), and group III (no staining, 63 tumors). Eight clinicopathologic variables showed a significant relationship with the staining pattern of CA19-9. The 5-yr survival rate of the group I subjects was significantly lower than that of the other two groups. With the multivariate analysis, the staining pattern of CA19-9 proved to be one of the independent prognostic variables.


CONCLUSIONS
In addition to conventional prognostic factors, the staining pattern of CA19-9 is considered to be of value in predicting the prognosis of patients with colorectal carcinomas.
Shimono
R
R
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Mori
M
M
Akazawa
K
K
Adachi
Y
Y
Sgimachi
K
K
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000276:immunology; D009367:Neoplasm Staging; D011379:Prognosis
D015295:Antigens, Tumor-Associated, Carbohydrate