title: Multiple myeloma and chronic myelogenous leukemia--a case report with literature review.
abstract: This is the case of a 71 year old male who developed multiple myeloma (MM) and chronic myelogenous leukemia (CML) within a two year period. The patient initially presented with osteolytic lesions of the lumbar spine, and following the initial work-up a diagnosis of multiple myeloma with an IgG kappa paraproteinemia was made and appropriate treatment was given. Two years later the patient developed a progressively worsening leukocytosis which was found to be due to Philadelphia Chromosome (Ph1) positive CML. The occurrence in the same patient of two distinct hematologic malignancies suggests a neoplastic transformation of a pluripotent stem cell. A review of the literature appears to support the existence of a relationship between MM and CML as well as a relationship between MM and the myeloproliferative disorders.
authors.affiliation: Department of Pathology and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
authors.forename: P J
authors.initials: PJ
authors.lastname: Klenn
authors.forename: B H
authors.initials: BH
authors.lastname: Hyun
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: W Y
authors.initials: WY
authors.lastname: Zheng
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male; D009101:Multiple Myeloma / Q000473:pathology*