title: A case of anti-nuclear antibody negative systemic lupus erythematosus associated with penile ulcer.
abstract: We report here an old male patient with anti-nuclear antibody (ANA) negative systemic lupus erythematosus (SLE) with active renal disease and penile ulcer. He revealed nephrotic syndrome, malar rash and oral ulcer. SLE was discussed, however both ANA and anti-DNA antibody were persistently negative. A penile ulcer was also observed. He died of acute respiratory distress. Autopsy findings including onion skin lesion in the spleen and haematoxylin body in the kidney resulted in the final diagnosis of SLE. To our knowledge, association of penile ulcer with SLE has not yet been reported. Therefore, the present case is thought to be extremely unusual.
authors.affiliation: Second Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Osawa
authors.forename: H
authors.initials: H
authors.lastname: Yamabe
authors.forename: K
authors.initials: K
authors.lastname: Ozawa
authors.forename: K
authors.initials: K
authors.lastname: Fukushi
authors.forename: H
authors.initials: H
authors.lastname: Inuma
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: S
authors.initials: S
authors.lastname: Seino
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: M
authors.initials: M
authors.lastname: Kaizuka
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D008181:Lupus Nephritis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000209:etiology* / Q000473:pathology; D013154:Spleen / Q000473:pathology; D014456:Ulcer / Q000209:etiology / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear