[The effect of nonsteroidal anti-inflammatory agents on erythrocyte osmotic resistance].
Effects of voltaren, surgam and isamben on erythrocyte membrane were studied. Voltaren and suggam, in dmM concentrations were to decrease, but in mM concentrations to increased hypotonic erythrocyte lysis. The role of erythrocyte membrane fluid is discussed with regard to this effect of the drugs, since voltaren or surgam, erythrocyte lysis even in isotonic medium at mM concentrations. In contrast to voltaren and surgam samben as had no effect on erythrocyte lysis in hypotonic or isotonic medium. In this connection, the relationship between membrane lytic effect and ulcerogenic potency of non-steroidal anti-inflammatory drugs is discussed.
Iakovenko
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D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006461:Hemolysis / Q000187:drug effects; D051379:Mice; D009930:Organic Chemicals; D009996:Osmotic Fragility / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009930:Organic Chemicals; D011422:Propionates; C085128:izamben; D004008:Diclofenac; C021270:tiaprofenic acid
Vliianie nesteroidnykh protivovospalitel'nykh sredstv na osmoticheskuiu rezistentnost' éritrotsitov.