Effect of S-carboxymethylcysteine on ciliary activity in chronic sinusitis.
This study was designed to investigate the possible pharmacological effect of S-carboxy-methylcysteine (S-CMC) on the ciliary activity, using an in vitro experimental system after removing mucus. Ciliary activity from healthy rabbit maxillary sinus and from healthy human nasal mucosa demonstrated no significant change in RPMI 1640 containing S-CMC. On the other hand, the effect of S-CMC on the reduced ciliary activity from patients with chronic sinusitis was quite varied among the cases examined. S-CMC demonstrated no stimulatory effect on the beating activity of cilia that have a baseline activity of less than 400 beats/min. However, S-CMC was able to enhance the beating activity of cilia that demonstrated a baseline activity of more than 400 beats/min. S-CMC at 0.5% induced a larger ciliostimulatory effect than 0.05% S-CMC. In conclusion, our study has clearly demonstrated that S-CMC could directly enhance ciliary activity of chronic sinusitis in the absence of significant organic change of ciliated cells.
Ohashi
Y
Y
Department of Otolaryngology, Osaka City University Medical School, Japan.
Nakai
Y
Y
Sugiura
Y
Y
Ohno
Y
Y
Okamoto
H
H
Hayashi
M
M
D000818:Animals; D002233:Carbocysteine / Q000494:pharmacology*; D002908:Chronic Disease; D002923:Cilia / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008443:Maxillary Sinus / Q000187:drug effects / Q000503:physiopathology*; D015523:Maxillary Sinusitis / Q000503:physiopathology*; D009297:Nasal Mucosa / Q000502:physiology; D011817:Rabbits
D002233:Carbocysteine