5-hydroxytryptamine 3-receptor antagonist modulates gallbladder emptying and motilin release induced by erythromycin.
In the present study we evaluated the effect of ondansetron (formerly indicated as GR38032F), a potent and selective type-3 5-hydroxytryptamine receptor antagonist, on erythromycin-induced gallbladder emptying and motilin release, as well as gallbladder emptying induced by a regular meal in healthy volunteers. Gallbladder emptying was evaluated by sonography. Ondansetron, at the dose of 0.05 mg/kg, significantly reduced (P < 0.001 by ANOVA) the gallbladder emptying induced by 2 mg/kg/hr erythromycin, but did not increase basal gallbladder volume or inhibit gallbladder emptying induced by a regular meal. Ondansetron also inhibited the motilin release induced by erythromycin (P < 0.001, by ANOVA). These results suggest that serotoninergic mechanisms modulate the effects of erythromycin on the gastrointestinal tract. The exact site of action of ondansetron remains to be identified.
Fiorucci
S
S
Istituto di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Italy.
Santucci
L
L
Morelli
A
A
D000328:Adult; D004917:Erythromycin / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005260:Female; D005502:Food; D016473:Gallbladder Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D009037:Motilin / Q000187:drug effects* / Q000378:metabolism; D017294:Ondansetron / Q000009:adverse effects / Q000494:pharmacology*; D012702:Serotonin Antagonists
D012702:Serotonin Antagonists; D017294:Ondansetron; D009037:Motilin; D004917:Erythromycin