The effects of long-term treatment with the 5-HT1A receptor agonist 8-OH-DPAT and the 5-HT2/1C receptor agonist DOI in the neonatal rat.
The rat pup ultrasonic call was used to study the effects of acute and long-term treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the 5-HT2/1C receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) during the neonatal period. Acute administration of 8-OH-DPAT and DOI reduced the number of ultrasonic calls. The reduction induced by 8-OH-DPAT and DOI was antagonized by the 5-HT1A antagonist (S)-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin ((S)-UH-301) and the 5-HT2 antagonist ketanserin, respectively. The long-term treatments were started on postnatal day 1. On postnatal day 7, the response of the long-term DOI-treated group was clearly attenuated in comparison to that of the acute DOI-treated group. In contrast, no tolerance to the effect of 8-OH-DPAT was achieved after an analogous treatment. The data indicate that there is a diversity in the ontogeny of the ability to develop tolerance to 5-HT1A agonists in comparison to 5-HT2/1C agonists.
Johansson-Wallsten
C E
CE
Uppsala University, Department of Medical Pharmacology, Sweden.
Berg
M
M
Meyerson
B J
BJ
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000662:Amphetamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007650:Ketanserin / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014828:Vocalization, Animal / Q000187:drug effects
D000662:Amphetamines; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C064282:UH 301; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine