[Prognostic value of Ia-antigen, fibronectin, laminin and type IV collagen in pulmonary squamous cell carcinoma].
Presence of absence of four immunohistological markers were investigated in fifty-four cases of pulmonary squamous cell carcinoma. Ia-antigen (HLA-DR), fibronectin (Fn), laminin (La), and type IV collagen were present in 9 cases (16.7%), 13 (24.0), 24 (44.4) and 12 (22.2) respectively. Three markers were present in 6 cases, two 13, one in 14 and none in 21. Higher positive rate of Fn among N (-) group in TNM classification was statistically significant when compared with that of N (+) group. In 13 of 14 cancer death cases, less than one markers were present, while all the cases in which more than two markers were present were alive during the follow up periods. The author concludes that Fn by itself is a useful prognostic indicator and when combined with other three markers, it can predict accurate prognosis.
Hisayoshi
T
T
Department of Surgery, Second Hospital, Nippon Medical School, Kawasaki, Japan.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D003094:Collagen / Q000032:analysis*; D005260:Female; D005353:Fibronectins / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007797:Laminin / Q000032:analysis*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
D014408:Biomarkers, Tumor; D005353:Fibronectins; D006684:HLA-DR Antigens; D007797:Laminin; D003094:Collagen