title: Percutaneous ultrasonic angioplasty: initial results of an in-vitro study on normal and atherosclerotic human vessel segments.
abstract: The aim of the present study was to assess the efficacy and safety of a new ultrasound catheter system in vitro before employing it in humans. Ultrasound energy was applied to 141 normal and atherosclerotic human vessel segments, obtained at autopsy. Macroscopical and histological examination of the treated vessel segments revealed that ultrasound energy is atraumatic to the normal vessel wall. In atherosclerotic vessel segments, there was macroscopically significant reduction in the size of plaques. In 7/10 completely occluded femoral arterial segments, recanalization could be achieved. The resulting lumen approximated the diameter of the wire probe. Therefore, ultrasound energy is an appealing form of energy for recanalization of completely obstructed atherosclerotic vessels and for disintegration of atherosclerotic plaques. Clinically, ultrasonic angioplasty may become an adjunctive modality to balloon angioplasty.
authors.affiliation: Department of Radiology, University of Mainz, Medical School, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Strunk
authors.forename: H
authors.initials: H
authors.lastname: Schild
authors.forename: W
authors.initials: W
authors.lastname: Steffen
authors.forename: P
authors.initials: P
authors.lastname: Stahr
authors.forename: R
authors.initials: R
authors.lastname: Erbel
mesh_terms: D000800:Angioplasty, Balloon / Q000295:instrumentation / Q000379:methods*; D001161:Arteriosclerosis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D066298:In Vitro Techniques; D014464:Ultrasonic Therapy