[HIV infection among type A and B hemophiliacs].
Evolution of HIV infection was studied in 480 hemophiliacs A and 78 hemophiliacs B treated in the "Centre-West" Region. 23.3% hemophiliacs A and 46.1% hemophiliacs B were contaminated by HIV. In this region, HIV seroprevalence in hemophiliacs A was lower than the prevalence noted at the national level (51.2%); this is certainly due to the use of frozen cryoprecipitates in the treatment of a high number of hemophiliacs A. A higher number of hemophiliacs B developed the disease: 12.5% hemophiliacs A versus 22% hemophiliacs B. Moreover hemophilic B patients had a more rapid evolution towards the disease since 6 out of 14 hemophiliacs A and 7 out of 8 hemophiliacs B with AIDS died. The fact that hemophiliacs B were significantly older than hemophiliacs A might be one of the reasons, but it must be noted that the contamination often occurred earlier in hemophiliacs B and was perhaps more important. The more severe evolution in the hemophiliac B group noted in our region is not found in American studies, which may be due to the different ways of preparing Factor IX concentrates in France and the United States.
Vicariot
M
M
Centre de Traitement de l'hémophilie, CHR de Brest.
Fressinaud
E
E
Fiks
M
M
Fonlupt
J
J
Berthier
A M
AM
Guerois
C
C
Fimbel
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004340:Drug Contamination; D005164:Factor IX / Q000627:therapeutic use*; D005169:Factor VIII / Q000627:therapeutic use*; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000635:transmission; D015528:HIV Seroprevalence; D006467:Hemophilia A / Q000453:epidemiology* / Q000628:therapy; D002836:Hemophilia B / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D007223:Infant; D015993:Life Tables; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D065227:Transfusion Reaction
D005169:Factor VIII; D005164:Factor IX
Infection VIH chez les hémophiles A et B.