[A new application of immunoconjugate to reduce the local recurrence of colorectal cancer].
To examine whether or not immunoconjugate-A7-NCS can contribute for the reduction of local recurrence of colorectal cancer, the present study was undertaken. The study included examination of local retension, lymphatic delivery and inhibitory effect on tumor development after local administration of A7-NCS. The result showed that locally injected A7-NCS showed a high local retension, a high regional lymph node accumulation and a high inhibitory effect on tumor development. This finding indicates that A7-NCS can be a new promising tool for reducing the local recurrence of colorectal cancer.
Kitamura
K
K
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Yamaguchi
T
T
Taniguchi
K
K
Katoh
M
M
Kotani
T
T
Yamaoka
N
N
Otsuji
E
E
Noguchi
A
A
Takahashi
T
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000922:Immunotoxins / Q000378:metabolism / Q000627:therapeutic use*; D008198:Lymph Nodes / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000517:prevention & control*; D009368:Neoplasm Transplantation; D009353:Zinostatin / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D009353:Zinostatin