title: Magnetic resonance imaging of thrombosed dural sinuses.
abstract: OBJECTIVE
  Magnetic resonance imaging should have the potential to replace angiography in the diagnosis of dural sinus thrombosis. Concerning time-dependent signal changes of the thrombus, we intended to develop a standardized examination protocol for routine use in suspected dural sinus thrombosis.
  
  
  METHODS
  The time-dependent signal changes of thrombosed dural sinuses were studied in 23 consecutive patients by multiplanar spin-echo and flow-sensitive sequences. Signal intensities and thrombus homogeneity were graded and related to the time after clinical onset and the results of the magnetic resonance angiography.
  
  
  RESULTS
  Four stages of the thrombus evolution could be observed. The acute thrombosis (days 1 to 5) appeared strongly hypointense in T2-weighted images and isointense in spin density- and T1-weighted images. In the subacute stage (up to day 15) the thrombus signal was strongly hyperintense in T1- and T2-weighted images. The third stage began in the third week after clinical onset. The thrombus signal was decreased in all sequences and showed an increasing inhomogeneity. The fourth (late) stage was characterized by either the restitution of blood flow or the persistence of a residual thrombus.
  
  
  CONCLUSIONS
  Each stage requires a different diagnostic approach. With the combined use of spin-echo and gradient-echo sequences, it is possible to make the diagnosis of acute thrombosis; in the second stage, multiplanar spin-echo sequences are sufficient. Diagnosis of dural sinus thrombosis can be established accurately with magnetic resonance imaging in the first two stages. However, the diagnosis of the later stages is difficult because of inhomogeneous signs of recanalization and flow phenomena. Therefore, a suspected older dural sinus thrombus still requires intra-arterial angiography as the primary diagnostic tool.
authors.affiliation: Department of Neurology, Klinikum RWTH Aachen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Isensee
authors.forename: J
authors.initials: J
authors.lastname: Reul
authors.forename: A
authors.initials: A
authors.lastname: Thron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002550:Cerebral Veins / Q000473:pathology*; D002648:Child; D004388:Dura Mater / Q000098:blood supply*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013997:Time Factors