title: Two bioactive pterocarpans from Erythrina burana.
abstract: Bioactivity-directed fractionation of the CHCl3 extract of the bark of Erythrina burana afforded phaseollidin [1] and cristacarpin [2]. Both 1 and 2 exhibited moderate but selective activity towards DNA repair-deficient yeast mutants, whereas only 1 was found to be cytotoxic. 13C-nmr spectra of both compounds were assigned.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
authors.forename: E
authors.initials: E
authors.lastname: Dagne
authors.forename: A A
authors.initials: AA
authors.lastname: Gunatilaka
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
authors.forename: M
authors.initials: M
authors.lastname: Alemu
authors.forename: G
authors.initials: G
authors.lastname: Hofmann
authors.forename: R K
authors.initials: RK
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005002:Ethiopia; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D036343:Pterocarpans; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D001578:Benzopyrans; D036343:Pterocarpans; C085158:phaseollidin; C085157:cristacarpin