Critique of the toxicology and carcinogenesis studies of iodinated glycerol in F344/N rats and B6C3F1 mice.
Carter-Wallace conducted a detailed audit and evaluation of the data available from the carcinogenicity studies with iodinated glycerol conducted in the B6C3F1 mouse and the F344/N rat by the National Toxicology Program (NTP). We conclude that there is no evidence of carcinogenicity of the compound in either the B6C3F1 mouse or the F344/N rat.
McGee
J H
JH
Wallace Laboratories, Division of Carter-Wallace Inc., Cranbury, New Jersey 08512.
Butler
W H
WH
Willigan
D A
DA
Brown
W R
WR
Sofia
R D
RD
D000236:Adenoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005100:Expectorants / Q000633:toxicity*; D005260:Female; D005990:Glycerol / Q000031:analogs & derivatives* / Q000633:toxicity; D007948:Leukemia, Monocytic, Acute / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus; D010222:Parainfluenza Virus 1, Human; D010911:Pituitary Neoplasms / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D015203:Reproducibility of Results
D002273:Carcinogens; D005100:Expectorants; C015372:iodinated glycerol; D005990:Glycerol