[Adverse effects of tamoxifen on the female genital tract].
Tamoxifen is an established adjuvant therapy for breast cancer. It exerts both estrogenic agonist and antagonist effects on target tissues. Since the use of tamoxifen is expanding, it is expected that more women will suffer from its side-effects. 3 women aged 48, 48, and 65, respectively, who were treated with tamoxifen, were referred for evaluation of possible side-effects. They had, respectively, endometrial hyperplasia, a unique sonographic appearance of the endometrium resembling neoplasia, and an ovarian cyst.
Anteby
E
E
Dept. of Obstetrics and Gynecology, Hadassah-University Hospital, Mt. Scopus, Jerusalem.
Yagel
S
S
Zacut
D
D
Palti
Z
Z
Hochner-Celnikier
D
D
D000368:Aged; D004714:Endometrial Hyperplasia / Q000139:chemically induced*; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010048:Ovarian Cysts / Q000139:chemically induced*; D013629:Tamoxifen / Q000009:adverse effects*; D014463:Ultrasonography
D013629:Tamoxifen