Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat.
Some men receiving gossypol in China developed elevated urinary N-acetyl-beta-glucosaminidase (NAG) levels and hypokalemia. Since idiopathic hypokalemia occurs in China, hypokalemic nephropathy may have caused the elevated NAG levels. To learn if gossypol is directly nephrotoxic, we treated rats with a normal or low potassium diet with or without gossypol. The low potassium diet produced high NAG levels rather than the gossypol. This indicates the importance of differentiating hypokalemic nephropathy from drug nephrotoxicity in regions where idiopathic hypokalemia occurs.
Wu
D
D
Department of Psychopharmacology, Addiction Research Foundation, Toronto, Ontario, Canada.
Reidenberg
M M
MM
D000118:Acetylglucosaminidase / Q000652:urine*; D000818:Animals; D006072:Gossypol / Q000633:toxicity*; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D011191:Potassium Deficiency / Q000150:complications / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000118:Acetylglucosaminidase; D006072:Gossypol