[The effect of liposome phospholipids in collagen-induced platelet aggregation].
Influence of the charge-bearing phospholipids containing in liposome membrane on collagen-induced platelet aggregation was studied. The aggregation was inhibited after preincubation of blood platelets with liposomes containing egg lecithin/cholesterol/phosphatidylserine (stearyl amine); the effect was dose-dependent. Phosphatidylinositol incorporated into liposomes did not affect distinctly thrombocytes activation but decreased the rate of cell disaggregation; this effect was also dose-dependent. Use of phosphatidylinositol containing liposomes did not affect the content of thromboxane and prostacyclin in the system. The effect of the charge-bearing phospholipids on platelet aggregation observed should be considered in production of medicinal drugs.
Zakrevskiĭ
V I
VI
Kubatiev
A A
AA
Galaev
Iu V
IuV
D000818:Animals; D003094:Collagen / Q000494:pharmacology*; D066298:In Vitro Techniques; D008081:Liposomes; D008297:Male; D010743:Phospholipids / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D008081:Liposomes; D010743:Phospholipids; D003094:Collagen
Effekt fosfolipidov liposom pri kollagenindutsirovannoĭ agregatsii trombotsitov.