Hepatitis B virus C-gene variants.
The heterogeneity of hepatitis B virus (HBV) is increasingly believed to play a role in viral persistence, pathogenesis, and the type of response to antiviral therapy. One of the best studied parts of the HBV genome is the C-gene which codes for the nucleocapsid protein (HBc) and the e-antigen (HBeAg). Here we attempt to review the recent data on the sequence heterogeneity of this region and its possible implications.
Miska
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Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Federal Republic of Germany.
Will
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H
D001483:Base Sequence; D005814:Genes, Viral; D006509:Hepatitis B / Q000382:microbiology; D006512:Hepatitis B Core Antigens / Q000235:genetics*; D006513:Hepatitis B e Antigens / Q000235:genetics*; D006515:Hepatitis B virus / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D012367:RNA, Viral; D014158:Transcription, Genetic; D014779:Virus Replication
D006512:Hepatitis B Core Antigens; D006513:Hepatitis B e Antigens; D012367:RNA, Viral