An antifungal bibenzyl from the New Zealand liverwort, Plagiochila stephensoniana. Bioactivity-directed isolation, synthesis, and analysis.
The bioactivity-directed isolation of 4-hydroxy-3'-methoxybibenzyl [1] from a New Zealand liverwort, Plagiochila stephensoniana, is described. Compound 1 exhibited antifungal and antibacterial activity. Compound 1 is not considered to be a useful taxonomic marker. Syntheses of 1, stilbenes 2 and 3, and some derivatives were made and the biological activities were compared.
Lorimer
S D
SD
Department of Chemistry, University of Otago, Dunedin, New Zealand.
Perry
N B
NB
Tangney
R S
RS
D000840:Anisoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001632:Bibenzyls; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009520:New Zealand; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D000840:Anisoles; D000935:Antifungal Agents; D000998:Antiviral Agents; D001632:Bibenzyls; D010636:Phenols; C084694:4-hydroxy-3'-methoxybibenzyl