Transfusion and second malignancy.
BACKGROUND
Perioperative blood transfusion has been reported to cause a variety of immunosuppressive effects, including increased rates of malignancy recurrence. The effect of perioperative transfusion on second malignancy risk has not previously been investigated.


METHODS
Second malignancy risk was evaluated in 1053 patients previously operated upon for colon cancer, and these findings are related to perioperative transfusion history.


RESULTS
Transfusion history did not relate to the probability of a patient's remaining free of second malignancy.


CONCLUSIONS
An increased risk of total or second malignancies (with the possible exception of lung cancer) was not associated with transfusion.
Ford
C D
CD
Tumor Registry, LDS Hospital, Salt Lake City, Utah.
Gillette
J W
JW
Handrahan
D L
DL
Koehler
C S
CS
D000368:Aged; D003106:Colon / Q000601:surgery; D015179:Colorectal Neoplasms / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D065227:Transfusion Reaction