Metal complexes of anti-inflammatory drugs. Part VIII: Suprofen complex of copper(II).
The preparation and properties of the copper(II) complex Cu(SUP)2.H2O are reported for the anti-inflammatory drug Suprofen (SUP). The diffuse reflectance spectra and magnetic moment are consistent with a dinuclear structure as found for [Cu(aspirinate)2(H2O)]2. The copper(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.
Underhill
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AE
Department of Chemistry, University College of North Wales, Bangor, Gwynedd, United Kingdom.
Bougourd
S A
SA
Flugge
M L
ML
Gale
S E
SE
Gomm
P S
PS
D003300:Copper / Q000737:chemistry*; D016166:Free Radical Scavengers; D008961:Models, Structural; D009942:Organometallic Compounds / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides; D013496:Suprofen / Q000031:analogs & derivatives* / Q000737:chemistry*
D016166:Free Radical Scavengers; D009942:Organometallic Compounds; C084744:suprofen-copper(II) complex; D013481:Superoxides; D003300:Copper; D013496:Suprofen; D013482:Superoxide Dismutase