title: Cardiovascular effects of isoflurane and halothane in young and elderly adult patients.
abstract: We have studied the cardiovascular effects of 1 MAC end-tidal concentrations of halothane and isoflurane in young (n = 40) and elderly (n = 40) adult patients using non-invasive techniques. Cardiac output was measured by Doppler ultrasonography. Halothane reduced heart rate, systolic, mean and diastolic arterial pressures and cardiac index in both age groups (P < 0.05). Isoflurane reduced systolic, mean and diastolic arterial pressures also, but reduced cardiac index and heart rate only in the older patients (P < 0.05). Halothane depressed cardiovascular state significantly more than isoflurane in the younger adults (P < 0.05), but cardiovascular depression was similar for the two agents in the older age group. The decreases in systolic and diastolic pressures in the older patients were significantly greater with isoflurane compared with halothane (P < 0.05).
authors.affiliation: Department of Anaesthetics, Queen's University of Belfast.
authors.forename: M S
authors.initials: MS
authors.lastname: McKinney
authors.forename: J P
authors.initials: JP
authors.lastname: Fee
authors.forename: R S
authors.initials: RS
authors.lastname: Clarke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003864:Depression, Chemical; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged
chemical_list: D007530:Isoflurane; D006221:Halothane