A possible role for bcl-2 in regulating T-cell memory--a 'balancing act' between cell death and survival.
One of the central questions in T-cell immunity is how the generation of T-cell memory may proceed simultaneously with the maintenance of T-cell homeostasis. In this article, we present a hypothesis that the regulation of bcl-2 gene expression within the activated CD45RO+ T-cell population may be one of the key factors in the balance between death and survival of these activated mature T cells, both in vitro and in vivo.
Akbar
A N
AN
Dept of Clinical Immunology, Royal Free Hospital School of Medicine, London, UK.
Salmon
M
M
Savill
J
J
Janossy
G
G
D000818:Animals; D016923:Cell Death; D002470:Cell Survival; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000276:immunology*; D019253:Proto-Oncogene Proteins c-bcl-2; D013601:T-Lymphocytes / Q000276:immunology*
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017493:Leukocyte Common Antigens