Management of acute radiodermatitis. Pharmacological or nonpharmacological remedies?
The medical and nursing literature suggests a wide variety of pharmacological and nonpharmacological approaches to treatment of acute radiation skin damages (erythema, dry and moist desquamation, ulceration), but no specific and standardized therapy. The incidence of radiodermatitis has decreased with mega-voltage instruments, but it can nevertheless influence the therapeutic program and impair quality of life of patients. A study has been conducted to evaluate the tolerability and effectiveness of a nonpharmacological remedy, a mixture of hydrophobic (stearic acid) and hydrophilic (propylene glycol, glycerol, and polyunsaturated alcohols) components in a foam emulsion for the treatment of acute skin injuries following radiotherapy. Thirty-eight of 42 initial patients were evaluable: we observed a complete response in 22 (57.9%), improvement in 14 (36.8%), and failure in only two (5.3%).
Dini
D
D
Cancer Rehabilitation Department, National Cancer Institute, Genoa, Italy.
Macchia
R
R
Gozza
A
A
Bertelli
G
G
Forno
G G
GG
Guenzi
M
M
Bacigalupo
A
A
Scolaro
T
T
Vitale
V
V
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004338:Drug Combinations; D004655:Emulsions; D005260:Female; D005990:Glycerol / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D011855:Radiodermatitis / Q000188:drug therapy* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D012074:Remission Induction; D013228:Stearates / Q000008:administration & dosage
C084869:Bioshield; D004338:Drug Combinations; D004655:Emulsions; D011837:Radiation-Protective Agents; D013228:Stearates; D005990:Glycerol