Massive precorneal extension of squamous cell carcinoma of the conjunctiva.
A 73-year-old man had only light perception vision from a slowly enlarging fleshy papillomatous mass covering the entire cornea. The lesion was excised completely, leaving a clear corneal bed and 20/25 vision. Histopathologically, the lesion was found to be squamous cell carcinoma in situ with early microinvasion of the basement membrane. Viral studies for human papilloma virus were negative. This case represents a massive superficial involvement of the cornea by squamous cell carcinoma and shows the resistance of Bowman's membrane to tumor penetration.
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Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Shields
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Shields
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Eagel
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De Potter
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Talansky
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D000368:Aged; D001485:Basement Membrane / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000601:surgery; D003316:Corneal Diseases / Q000473:pathology* / Q000601:surgery; D003452:Cryosurgery; D005134:Eye Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D014792:Visual Acuity