title: Multiple primary carcinoma of the oesophagus.
abstract: A retrospective evaluation of 239 patients with primary oesophageal carcinoma who underwent oesophagectomy without preoperative treatment revealed 45 cases (18.8%) of multiple primary oesophageal carcinoma (MPEC). The average age of the patients with MPEC was significantly lower than that of patients with single primary oesophageal carcinoma (SPEC) (P = 0.005). The incidence of association with pharyngeal malignancy was higher in patients with MPEC than in those with SPEC (P = 0.080). The number of patients in the category representing a combination of heaviest alcohol and cigarette use was significantly higher in the MPEC patients (P = 0.035). The high incidence of MPEC points to a need for careful checking of the oesophagus at the time of surgical treatment for oesophageal carcinoma. Low age at onset, a combination of heavy smoking and drinking, and association with pharyngeal malignancy are considered to be high-risk factors for MPEC.
authors.affiliation: Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mizobuchi
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Tachimori
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Itabashi
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D004938:Esophageal Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects