title: Modelling of serial carcinoembryonic antigen changes in colorectal cancer.
abstract: Carcinoembryonic antigen (CEA) is a tumour marker mainly used for detection of recurrent colorectal cancer. CEA series in 295 patients, who had a macroscopic radical resection of a primary colorectal cancer were studied. A kinetic model was fitted to CEA series of individual patients. Applying the kinetic model recurrences were identified with a sensitivity of 70-80% and specificity of 80-90%. Simulations were performed in order to find the optimal sampling strategy for CEA during follow-up. Simulations showed that CEA determinations at a few weeks interval between would be optimal for early detection of recurrences.
authors.affiliation: Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus.
authors.forename: J
authors.initials: J
authors.lastname: Carl
authors.forename: S M
authors.initials: SM
authors.lastname: Bentzen
authors.forename: B
authors.initials: B
authors.lastname: Nørgaard-Pedersen
authors.forename: O
authors.initials: O
authors.lastname: Kronborg
mesh_terms: D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009364:Neoplasm Recurrence, Local / Q000097:blood
chemical_list: D002272:Carcinoembryonic Antigen