Modulation of feeding and drinking by dopamine in caudate and accumbens nuclei in rats.
Injection of dopamine (DA) into accumbens and caudate nuclei facilitates a dose-dependent increase in food and water intake, whereas administration of spiperone (SP), a central D2-receptor antagonist suppresses DA-facilitated food and water intake. Bilateral lesions of nucleus accumbens and caudatus result in a sustained and significant decrease in food and water intake. The results suggest that DA is a neurotransmitter involved in feeding and drinking behavior in accumbens and caudate nuclei and this effect is mediated by central D2 receptors.
Pal
G K
GK
Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry, India.
Thombre
D P
DP
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology* / Q000502:physiology; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013134:Spiperone / Q000494:pharmacology
D013134:Spiperone; D004298:Dopamine