title: Comparative pathogenicity and serogrouping of three Washington isolates of infectious bursal disease virus.
abstract: The pathology of three infectious bursal disease virus (IBDV) isolates of Washington poultry origin (WA-678, WA-770, and WA-994) and seven other known IBDV strains (SAL, D-78, MO, OH, Var-A, 2512, and IM) was studied in 3-week-old specific-pathogen-free chickens. Inoculation with IM and 2512 strains resulted in illness and death. No clinical signs or mortality were present with WA-678, WA-770, and WA-994. Macroscopically, bursae were swollen and gelatinous with occasional hemorrhages. Isolate WA-994 caused marked bursal atrophy. Isolate WA-678 elicited moderate bursal pathology. Isolate WA-770 resulted in minimal atrophy. Strains IM and 2512 caused severe bursal atrophy, and strains Var-A and D-78 caused moderate atrophy. Strains SAL, MO, and OH caused no demonstrable bursal atrophy. Results of the cross-neutralization study showed that the three isolates were more closely related to serotype 1 than to serotype 2 IBDV.
authors.affiliation: Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164.
authors.forename: E
authors.initials: E
authors.lastname: Alamsyah
authors.forename: A S
authors.initials: AS
authors.lastname: Dhillon
authors.forename: J F
authors.initials: JF
authors.lastname: Evermann
mesh_terms: D000818:Animals; D018175:Birnaviridae Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D007243:Infectious bursal disease virus / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D009500:Neutralization Tests; D011201:Poultry Diseases / Q000382:microbiology* / Q000473:pathology; D012703:Serotyping; D014774:Virulence; D014861:Washington