Polylactide inhibition of carcinoma cell growth in vitro.
Normal fibroblasts and epithelial tumor cells were challenged by exposure for 24 hours to extracts of a pure metal, a metal alloy, and a polymer used in facial reconstruction to assess cellular growth effects. While none of these materials significantly altered fibroblast growth rates, poly-L-lactide inhibited carcinoma cell growth at 5.0% extract concentration. No carcinoma cell growth effects were seen from exposure to stainless steel or commercially pure titanium extracts.
Campbell
J H
JH
Orofacial Medicine Division, Head and Neck Center, Sisters of Charity Hospital, Buffalo, NY.
Edsberg
L
L
Meyer
A E
AE
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008648:Mesoderm / Q000187:drug effects; D011091:Polyesters / Q000494:pharmacology* / Q000627:therapeutic use; D019736:Prostheses and Implants; D013193:Stainless Steel / Q000633:toxicity; D014025:Titanium / Q000633:toxicity; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D011091:Polyesters; D013193:Stainless Steel; C033616:poly(lactide); D014025:Titanium