Husbandry factors and the prevalence of age-related amyloidosis in mice.
A retrospective study of the prevalence of amyloidosis in mice from several facilities was done. Amyloid deposition is an age-related lesion. The influence of common laboratory factors on the occurrence of this lesion was analyzed. This study documented genotypic difference in susceptibility to amyloidosis and showed that caging and pathogen status both impact on the number of cases of amyloidosis seen in a population. The lowest percentage of affected mice was seen when the animals were individually caged in a specific pathogen-free facility where conditions of stress were minimized.
Lipman
R D
RD
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Gaillard
E T
ET
Harrison
D E
DE
Bronson
R T
RT
D000367:Age Factors; D000686:Amyloidosis / Q000453:epidemiology / Q000662:veterinary*; D000822:Animal Husbandry; D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D013047:Specific Pathogen-Free Organisms