[Changes in the population composition and the rates of proliferation and specialization of erythroid cells in rats with experimental anemia].
Cytomorphologic, morphometric and population analyses have revealed that during acute anemia, induced by phenylhydrazin, the proliferative activity of erythroblasts increases, an abrupt change in the structures of erythroid populations of both bone marrow and peripheral blood is observed, together with the increase in the rates of their specialization. Also, the ratio of the stem cells which differentiate by the erythroid pathway is increased, and the macro- and microcytosis mechanisms, which are essentially salient in normal conditions, are switched on. The roles of macro- and microcytes in the restoration of the normal amount of erythroid cells and haemoglobin contents in the blood are discussed.
Magakian
Iu A
IuA
Karalova
E M
EM
Abroian
L O
LO
D000208:Acute Disease; D000740:Anemia / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002454:Cell Differentiation; D002455:Cell Division; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000473:pathology*; D005260:Female; D008297:Male; D010659:Phenylhydrazines; D051381:Rats; D013997:Time Factors
D010659:Phenylhydrazines; C030299:phenylhydrazine
Izmeneniia sostava populiatsii, tempov proliferatsii i spetsializatsii kletok éritroidnogo riada krys pri éksperimental'noĭ anemii.