title: Effect of iron and estrogen on melatonin secretion by the chicken pineal gland.
abstract: Estrogen effects on pineal secretion of melatonin are controversial. Some feel that estrogen inhibits melatonin output in vitro but not in vivo. Melatonin levels vary with the age in chickens where circulating estrogen levels also vary. Laying hens have minimal melatonin levels and maximal serum iron concentrations. Thus, we reasoned that iron released by estrogen may inhibit melatonin secretion from the chick pineal gland. The present study shows that perifusion of estrogen-treated chick pineal glands with several concentrations of iron greatly inhibited melatonin secretion.
authors.affiliation: Departamento Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias, Valladolid, Spain.
authors.forename: M I
authors.initials: MI
authors.lastname: Pablos
authors.forename: M T
authors.initials: MT
authors.lastname: Agapito
authors.forename: J M
authors.initials: JM
authors.lastname: Recio
authors.forename: L
authors.initials: L
authors.lastname: Pérez-Gallardo
authors.forename: M D
authors.initials: MD
authors.lastname: Córdova
authors.forename: J O
authors.initials: JO
authors.lastname: Mori
mesh_terms: D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D004967:Estrogens / Q000494:pharmacology*; D066298:In Vitro Techniques; D007501:Iron / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D010870:Pineal Gland / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011863:Radioimmunoassay; D013054:Spectrophotometry, Atomic
chemical_list: D004967:Estrogens; D007501:Iron; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin