title: Normal fetal outcome in a pregnancy with central nervous system toxoplasmosis and human immunodeficiency virus infection. A case report.
abstract: A pregnant woman was diagnosed with central nervous system toxoplasmosis and human immunodeficiency virus infection. Diagnosis was made by evaluating computed tomography scan results and toxoplasma antibody titers. The patient was treated with pyrimethamine and sulfadiazine, with an excellent fetal outcome. She responded well to this regimen but developed a delayed exanthematous hypersensitivity reaction. Treatment with a substitute regimen resulted in a recurrence of symptoms, leaving undesirable neurologic deficits.
authors.affiliation: Department of Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University, Harlem Hospital Center, New York, New York.
authors.forename: H L
authors.initials: HL
authors.lastname: Hedriana
authors.forename: J L
authors.initials: JL
authors.lastname: Mitchell
authors.forename: G M
authors.initials: GM
authors.lastname: Brown
authors.forename: S B
authors.initials: SB
authors.lastname: Williams
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000188:drug therapy; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D004342:Drug Hypersensitivity / Q000209:etiology; D004359:Drug Therapy, Combination; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D006801:Humans; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000188:drug therapy; D011256:Pregnancy Outcome; D011379:Prognosis; D011739:Pyrimethamine / Q000009:adverse effects / Q000627:therapeutic use; D012008:Recurrence; D013411:Sulfadiazine / Q000009:adverse effects / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014122:Toxoplasma / Q000276:immunology*; D016781:Toxoplasmosis, Cerebral / Q000097:blood / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000188:drug therapy; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D000913:Antibodies, Protozoan; D013411:Sulfadiazine; D015215:Zidovudine; D011739:Pyrimethamine