[The behavioral effects of beta-casomorphin-7 and its des-Tyr analogs].
The effects of intraperitoneal administration of the heptapeptide beta-casomorphin-7 (beta-K-7) and its des-Tyr analogues (beta-K-6 and beta-K-4) on spontaneous locomotor activity were investigated in rats using "Opto-Varimax", "RODEO-2" and "open field" tests. At 20 mg/kg 5 minutes prior to the beginning of measurements beta-K-7 produced a significant decrease in linear locomotion and rearing. As for beta-K-6 and beta-K-4, their influence on locomotion of the experimental animals was less evident. In contrast to beta-K-7, its des-Tyr analogues (20 mg/kg) produced a marked decrease in nose-poking behavior. Beta-K-7 in doses that had no effect on spontaneous behaviour (1 and 5 mg/kg) attenuated extreme behavioural displays under stress conditions. The experimental results suggest the advisability of further investigations of neurotropic properties of beta-K-7 and related peptides.
Maklakova
A S
AS
Dubynin
V A
VA
Levitskaia
N H
NH
Nezavibat'ko
V N
VN
Alfeeva
L A
LA
Kamenskiĭ
A A
AA
Ashmarin
I P
IP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002364:Caseins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology
D002364:Caseins; D004723:Endorphins; D010446:Peptide Fragments; C041128:beta-casomorphin 7; C059556:beta-casomorphin, des-Tyr-
Povedencheskie éffekty beta-kazomorfina-7 i ego dez-Tyr-analogov.