[In vivo studies on PGE2 production by human hepatocellular carcinoma xenografts in nude mice].
The PGE2 concentration of sera and tumor tissues in human hepatocellular carcinoma (hHCC) xenografts in nude mice was examined by radio-immuno-assay (RIA) and the effect of intraperitoneal administration of exogenous of PGE2 as well as indomethacin on tumor growth was studied. The results showed that: (1) Plasma and tumor tissue PGE2 levels of hHCC-bearing nude mice were significantly increased for 1 or 2 weeks after tumor inoculation. (2) Exogenous administration of indomethacin markedly suppressed the elevation of plasma and tissue PGE2 levels and prolonged the latent period of tumor growth. (3) Exogenous PGE2 shortened the latent period of tumor growth. This study indicates that there is intimate relation between PGE2 and hHCC growth.
Shi
L H
LH
Institute of Hepatobiliary Surgery, Chang Hai Hospital, Second Military University.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000378:metabolism*; D015232:Dinoprostone / Q000096:biosynthesis* / Q000627:therapeutic use; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011863:Radioimmunoassay
D015232:Dinoprostone; D007213:Indomethacin