[Indoles. 9. 4-Arylated tetrahydro-beta-carbolines--synthesis and first pharmacologic data].
Two different routes lead to the 4-arylated tetrahydro-beta-carbolines 5, 11, 12. One includes Pictet-Spengler cyclization of tryptamines 9, the other follows our "lactone-route", starting with 1 via 2-4. In a first pharmacological screening some target compounds show significant affinity at the 5-HT2-receptor but no or only low affinity to other binding sites.
Lehmann
J
J
Pharmazeutisches Institut, Universität Bonn.
Jiang
N
N
Behncke
A
A
D000818:Animals; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D002243:Carbolines; D011985:Receptors, Serotonin
Indole, 9. Mitt.: 4-Arylierte Tetrahydro-beta-carboline--Synthesewege und erste pharmakologische Daten.