HLA supratypes in an Italian population.
A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasoid populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.
D'Alfonso
S
S
Department of Genetics, Biology, and Medical Chemistry, Torino University, Italy.
Cappello
N
N
Borelli
I
I
Mazzola
G
G
Peruccio
D
D
Giordano
M
M
Cascino
I
I
Tosi
R
R
Richiardi
P M
PM
D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006682:HLA-DP Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007558:Italy; D011110:Polymorphism, Genetic
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens