title: Multicenter phase II study of brequinar sodium in patients with advanced breast cancer.
abstract: In this study, 34 patients with advanced breast cancer were treated with brequinar sodium: 75% of the patients were postmenopausal, and 94% had received chemotherapy previously; 50% had previously received an anthracycline-containing regimen. Brequinar was administered intravenously at a median weekly dose of 1,200 mg/m2. The toxicity was moderate, with 17 patients (50%) experiencing grade 3 or 4 toxicity. There were 33 patients evaluable for response: 4 patients (12%; 95% confidence interval, 3.4-28.2%) achieved partial responses, 10 patients (30%) were stable, and 19 patients (58%) had progressive disease. We conclude that, at this dose and schedule, brequinar has only modest activity in patients with advanced breast cancer.
authors.affiliation: University of Michigan, Ann Arbor.
authors.forename: R
authors.initials: R
authors.lastname: Cody
authors.forename: D
authors.initials: D
authors.lastname: Stewart
authors.forename: M
authors.initials: M
authors.lastname: DeForni
authors.forename: M
authors.initials: M
authors.lastname: Moore
authors.forename: B
authors.initials: B
authors.lastname: Dallaire
authors.forename: N
authors.initials: N
authors.lastname: Azarnia
authors.forename: J
authors.initials: J
authors.lastname: Gyves
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011798:Quinaldines
chemical_list: D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; C046943:brequinar; D011798:Quinaldines