title: Intracranial aneurysm formation following radiotherapy.
abstract: Two patients sustained a subarachnoid haemorrhage secondary to radiation-induced vasculopathy and associated aneurysm. A 65-year-old woman was treated by radiotherapy for a stereotactically biopsied left parieto-temporal astrocytoma. Three-and-a-half years later, she suffered a subarachnoid haemorrhage secondary to a giant aneurysm arising from the middle cerebral artery bifurcation. A 44-year-old man sustained a subarachnoid haemorrhage 21 years after receiving whole brain irradiation for a large left parietal angioma. Angiography following his subarachnoid haemorrhage revealed a distal right middle cerebral artery aneurysm that was not visible on earlier angiograms. Both patients underwent craniotomy for their aneurysms with good postoperative recoveries.
authors.affiliation: Department of Neurosurgery, Atkinson Morley's Hospital, Wimbledon, London, UK.
authors.forename: A T
authors.initials: AT
authors.lastname: Casey
authors.forename: H T
authors.initials: HT
authors.lastname: Marsh
authors.forename: D
authors.initials: D
authors.lastname: Uttley
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000532:radiotherapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D006391:Hemangioma / Q000532:radiotherapy; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology* / Q000601:surgery; D008297:Male; D011832:Radiation Injuries / Q000209:etiology* / Q000601:surgery; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000601:surgery