title: Prepubescent pituitary null cell macroadenoma with silent macroscopic apoplexy: case report.
abstract: Secreting pituitary adenomas have marked prevalence in pediatric adenomas. We described a case of an 11-year-old boy with pituitary null cell macroadenoma with silent macroscopic pituitary apoplexy. The patient was admitted with bitemporal hemianopsia and a gradual deterioration of visual acuity. An endocrinological study revealed a low concentration of testosterone and in the plasma a decreased response of luteinizing hormone and follicle-stimulating hormone to luteinizing hormone-releasing hormone. This patient may be the first case of prepubescent null cell macroadenoma confirmed with immunohistochemical study in addition to the findings of classical histopathology.
authors.affiliation: Department of Neurosurgery, Showa General Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mizutani
authors.forename: A
authors.initials: A
authors.lastname: Teramoto
authors.forename: T
authors.initials: T
authors.lastname: Aruga
authors.forename: K
authors.initials: K
authors.lastname: Takakura
authors.forename: N
authors.initials: N
authors.lastname: Sanno
mesh_terms: D000238:Adenoma, Chromophobe / Q000473:pathology* / Q000601:surgery; D002455:Cell Division / Q000502:physiology; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007016:Hypophysectomy; D008297:Male; D010899:Pituitary Apoplexy / Q000473:pathology* / Q000601:surgery; D010901:Pituitary Function Tests; D010902:Pituitary Gland / Q000473:pathology; D010908:Pituitary Hormones, Anterior / Q000032:analysis; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D010908:Pituitary Hormones, Anterior