title: Hyperprolactinaemia and infertility following cranial irradiation for brain tumours: successful treatment with bromocriptine.
abstract: Two young women developed oligomenorrhoea and galactorrhoea 4 and 7 years after whole brain irradiation for brain tumours. Both had mild hyperprolactinaemia due to irradiation-induced hypothalamic damage. In both patients, oral bromocriptine normalized prolactin levels and menstruation resumed. One patient then had a successful pregnancy.
authors.affiliation: Mersey Regional Department of Neurological Sciences, Walton Hospital, Liverpool, UK.
authors.forename: T
authors.initials: T
authors.lastname: Petterson
authors.forename: I A
authors.initials: IA
authors.lastname: MacFarlane
authors.forename: P M
authors.initials: PM
authors.lastname: Foy
authors.forename: H J
authors.initials: HJ
authors.lastname: Hughes
authors.forename: B
authors.initials: B
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Shaw
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000532:radiotherapy*; D001971:Bromocriptine / Q000627:therapeutic use*; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D005909:Glioblastoma / Q000532:radiotherapy; D005910:Glioma / Q000532:radiotherapy; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000209:etiology*; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology*; D009839:Oligomenorrhea / Q000209:etiology; D011832:Radiation Injuries / Q000188:drug therapy / Q000209:etiology*
chemical_list: D001971:Bromocriptine