title: [Experience with the combined diagnosis and therapy of locally advanced carcinoma of the uterine cervix (stage FIGO IIB-III). Transrectal ultrasonography and CT in the staging and in follow-up after therapy. Preliminary results].
abstract: The diagnosis, staging, therapy and follow-up of advanced epidermoid cervical carcinoma (FIGO stages IIB-III) have been studied in our university since January 1990. By December 1992, a team of specialists including radiologists, radiotherapists, gynecologists and pathologists divided 54 patients into two random treatment groups: group A patients, after systemic chemotherapy (CDP, 2 cycles) and diagnostic reevaluation, underwent radical surgery; group B patients received conventional radiotherapy alone (ERT 45 Gy+IRT or END-RT 20-25 Gy). All patients were examined by means of transrectal US (TRUS) and CT, after clinical examination under sedation, at staging and during the follow-up. The exams were performed periodically for group B patients and after systemic chemotherapy for group A patients. Imaging findings were compared with pathology only in group A. All imaging results were filed. The results confirm some literature data--e.g., 62% diagnostic accuracy for CT and 69% for TRUS, with higher diagnostic accuracy of the latter to evaluate cervical volume and to diagnose local relapses. As for parametrial involvement, both imaging methods tend to understage the early involvement, but only CT tends to overstage the lesions, especially in irradiated patients, due to fibrosclerosis phenomena. TRUS exhibited 69% accuracy, 70% sensitivity and 69% specificity, versus 61%, 62% and 60%, respectively, for CT; clinical examination under sedation had 58%, 60% and 60%, respectively. Both TRUS and CT are faster than endoscopic methods in evaluating vesical and/or rectal involvement. Lymph node metastases at staging, especially those in lumboaortic locations, proved to be unfavorable prognostic signs, as demonstrated by lumboaortic lymph node relapses in 5 group B patients (only 2 of them presented with lymph node metastases at staging; 3 patients had micronodules near the renal vessels), in spite of good local response after radiotherapy. In conclusion, we would like to point out that our team has had an MR unit at its disposal only recently: since the method is considered as the gold standard of imaging, especially in this kind of lesions, the study is still in progress.
authors.affiliation: Istituto di Radiologia Settore di Radiodiagnostica, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma.
authors.forename: P
authors.initials: P
authors.lastname: Marano
authors.forename: V
authors.initials: V
authors.lastname: Summaria
authors.forename: D
authors.initials: D
authors.lastname: Smaniotto
authors.forename: F M
authors.initials: FM
authors.lastname: Danza
authors.forename: S
authors.initials: S
authors.lastname: Speca
authors.forename: A L
authors.initials: AL
authors.lastname: Valentini
authors.forename: S
authors.initials: S
authors.lastname: Greggi
authors.forename: M
authors.initials: M
authors.lastname: Lancia
authors.forename: N
authors.initials: N
authors.lastname: Cellini
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012007:Rectum; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*
vernacular_title: Esperienza dell'integrazione diagnostica e terapeutica nel carcinoma della cervice uterina localmente avanzato (stadi FIGO IIB-III). Ecografia transrettale e TC nella stadiazione e nel controllo dopo terapia. Risultati preliminari.