title: Synthesis and evaluation of gastroprotective activity of omeprazole related benzimidazole, imidazo[4,5-b]pyridine and quinoxaline 2-substituted derivatives.
abstract: Twenty compounds possessing benzimidazole, imidazo[4,5-b]pyridine and quinoxaline structure bearing either a substituted arylmethylmercapto- or an arylmethylsulfinyl group in position 2 were prepared in order to evaluate an antiulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole at the dose of 50 mg/kg after i.m. administration. One third of these compounds showed a moderate activity, being about half potent as omeprazole.
authors.affiliation: Istituto di Chimica Farmaceutica e'Tossicologica dell'Università di Sassari.
authors.forename: S
authors.initials: S
authors.lastname: Piras
authors.forename: M
authors.initials: M
authors.lastname: Loriga
authors.forename: G
authors.initials: G
authors.lastname: Paglietti
authors.forename: F
authors.initials: F
authors.lastname: Sparatore
authors.forename: M P
authors.initials: MP
authors.lastname: Demontis
authors.forename: M V
authors.initials: MV
authors.lastname: Varoni
authors.forename: M C
authors.initials: MC
authors.lastname: Fattaccio
authors.forename: V
authors.initials: V
authors.lastname: Anania
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D011687:Purines / Q000737:chemistry / Q000494:pharmacology*; D011708:Pylorus / Q000187:drug effects; D011810:Quinoxalines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D011687:Purines; D011810:Quinoxalines; C064191:1H-imidazo(4,5-b)pyridine; C031000:benzimidazole; D009853:Omeprazole