title: Circadian rhythm of neuropeptide Y-like immunoreactivity in the iris-ciliary body of the rat.
abstract: Neuropeptide Y (NPY)-like immunoreactivity (LI) in the iris-ciliary body of rats kept under constant darkness (DD) and in 12 h light-12 h dark cycle (LD) was determined by enzyme immunoassay. NPY-LI contents in the iris-ciliary body were found to oscillate in circadian fashion under DD and LD conditions, with a peak at about circadian time 12 (CT 12) and a trough at around CT 0. Unilateral superior cervical ganglionectomy caused a significant decrease in NPY-LI levels in the sympathectomized eye compare to the contralateral intact eye, independent of lighting phase. These results suggest the presence of an endogenous circadian rhythm in NPY-LI content in the rat iris-ciliary body, and the possible involvement of a sympathetic input from the superior cervical ganglion.
authors.affiliation: Laboratory of Integrative Brain Function, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Otori
authors.forename: F A
authors.initials: FA
authors.lastname: Cagampang
authors.forename: S
authors.initials: S
authors.lastname: Yamazaki
authors.forename: S T
authors.initials: ST
authors.lastname: Inouye
authors.forename: T
authors.initials: T
authors.lastname: Mano
authors.forename: Y
authors.initials: Y
authors.lastname: Tano
mesh_terms: D000818:Animals; D002924:Ciliary Body / Q000294:innervation / Q000378:metabolism*; D002940:Circadian Rhythm; D003623:Dark Adaptation; D005728:Ganglia, Sympathetic / Q000601:surgery; D015171:Ganglionectomy; D007124:Immunoenzyme Techniques; D007498:Iris / Q000294:innervation / Q000378:metabolism*; D008027:Light; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009478:Neuropeptide Y