title: Selligueain A, a novel highly sweet proanthocyanidin from the rhizomes of Selliguea feei.
abstract: Selligueain A, a novel sweet trimeric proanthocyanidin with a doubly linked A unit, has been isolated from the rhizomes of Selliguea feei collected in Indonesia. The structure of this substance was established as epiafzelechin-(4 beta-->8, 2 beta-->O-->7)-epiafzelechin-(4 beta-->8)-afzelechin [1], on the basis of a combination of spectral and chemical methods. The compound was not acutely toxic for mice and not mutagenic in a forward mutation assay utilizing Salmonella typhimurium strain TM677. Selligueain A [1] was rated by a taste panel as exhibiting about 35 times the sweetness intensity of a 2% w/v aqueous sucrose solution, and at a concentration of 0.5% w/v in H2O was perceived as pleasant-tasting rather than astringent.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612.
authors.forename: N I
authors.initials: NI
authors.lastname: Baek
authors.forename: M S
authors.initials: MS
authors.lastname: Chung
authors.forename: L
authors.initials: L
authors.lastname: Shamon
authors.forename: L B
authors.initials: LB
authors.lastname: Kardono
authors.forename: S
authors.initials: S
authors.lastname: Tsauri
authors.forename: K
authors.initials: K
authors.lastname: Padmawinata
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000009:adverse effects / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D044945:Proanthocyanidins; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013549:Sweetening Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D013649:Taste / Q000187:drug effects
chemical_list: D000872:Anthocyanins; D044945:Proanthocyanidins; D013549:Sweetening Agents; C084699:selligueain A; C013221:proanthocyanidin