Effectiveness of the elcatonin transdermal system for the treatment of osteoporosis and the effect of the combination of elcatonin and active vitamin D3 in rat.
The efficacy of percutaneous elcatonin (EC), a hypocalcemic peptide, in the treatment of experimental osteoporosis in rats was evaluated in vivo. Additionally, the effect of the combined use of EC and active vitamin D3 (1,25(OH)2D3) for the treatment was compared with those of three other groups: 1,25(OH)2D3 alone, estradiol plus 1,25(OH)2D3, and a placebo, and low calcium diet (low Ca). The EC transdermal system and the EC plus 1,25(OH)2D3 system, applied to the rat abdominal skin 6 times for 48 h, significantly increased the ash weight and calcium content of the tibia in the rats, compared with those of placebo group (p < 0.05). The EC systems also slightly lowered the alkaline phosphatase activity in plasma of the morbid rats, without a difference in the plasma calcium content. These EC systems were superior to the 1,25(OH)2D3 system and the estradiol plus 1,25(OH)2D3 system in improving osteoporotic parameters. Thus, the EC systems were concluded to be an efficient drug delivery system for Paget's disease and osteoporosis.
Ogiso
T
T
Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Japan.
Iwaki
M
M
Tanino
T
T
Paku
T
T
D000279:Administration, Cutaneous; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002116:Calcitonin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002117:Calcitriol / Q000008:administration & dosage / Q000627:therapeutic use*; D002136:Calcium, Dietary / Q000008:administration & dosage; D004195:Disease Models, Animal; D004338:Drug Combinations; D004357:Drug Synergism; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D009824:Ointments; D010024:Osteoporosis / Q000188:drug therapy*; D010758:Phosphorus / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000737:chemistry / Q000187:drug effects
D002136:Calcium, Dietary; D004338:Drug Combinations; D009824:Ointments; D010758:Phosphorus; D004958:Estradiol; D002116:Calcitonin; D002117:Calcitriol; C012755:elcatonin