title: Osmotically induced tissue expansion with hydrogels: a new dimension in tissue expansion? A preliminary report.
abstract: The possibility of using an osmotically-driven system for effective tissue expansion has been verified. As a biocompatible and efficient system, a copolymer of methylmethacrylate and vinylpyrrolidone is used in animal research (rats). This hydrogel was able to generate, in vitro, a physical swelling pressure of approximately 235 mm Hg. The range of possible volume expansion in solutions of differing concentrations was 3 to 30 times its water-free gel form. In animal experiments a high biocompatibility and efficiency in tissue expansion can be observed.
authors.affiliation: Department of Maxillofacial Surgery, Georg-August-Universität Göttingen, Germany.
authors.forename: K G
authors.initials: KG
authors.lastname: Wiese
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005782:Gels; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000737:chemistry*; D009997:Osmotic Pressure; D011108:Polymers; D011205:Povidone / Q000737:chemistry*; D011760:Pyrrolidinones; D051381:Rats; D017208:Rats, Wistar; D012867:Skin; D015626:Tissue Expansion / Q000379:methods*; D015625:Tissue Expansion Devices
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D008768:Methylmethacrylates; D011108:Polymers; D011760:Pyrrolidinones; D020366:Methylmethacrylate; C037334:poly(methylmethacrylate-N-vinylpyrrolidone); C042670:N-vinyl-2-pyrrolidinone; D011205:Povidone