title: RNA editing in Newcastle disease virus.
abstract: The co-transcriptional editing of the Newcastle disease virus (NDV) P gene has been studied by sequence analysis of cloned viral genomic RNA and mRNA. Evidence has been obtained for the specific insertion of non-templated G nucleotides, the consequence of which is the generation of three populations of P gene-derived mRNAs. The three populations encode proteins (P, V and W) which have a common N-terminal region, but which utilize three different reading frames at their C termini. Paradoxically, NDV edits its P gene mRNA by the insertion of non-templated G residues in a manner similar to Sendai and measles viruses (P-->V editing) despite its apparent closer evolutionary relationship to the simian virus type 5, mumps and related group of viruses which edit a V genomic sequence to generate an mRNA to encode a functional P protein (V-->P editing).
authors.affiliation: Department of Biochemistry and Genetics, Medical School, University of Newcastle upon Tyne, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Steward
authors.forename: I B
authors.initials: IB
authors.lastname: Vipond
authors.forename: N S
authors.initials: NS
authors.lastname: Millar
authors.forename: P T
authors.initials: PT
authors.lastname: Emmerson
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005814:Genes, Viral / Q000235:genetics*; D008969:Molecular Sequence Data; D009522:Newcastle disease virus / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D017393:RNA Editing; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D016364:Reading Frames / Q000235:genetics; D018108:Respirovirus / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic / Q000235:genetics*; D017361:Viral Nonstructural Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics*; D015678:Viral Structural Proteins / Q000145:classification / Q000235:genetics*
chemical_list: C070065:36 kDa V protein, Newcastle disease virus; C055691:P phosphoprotein, Newcastle disease virus; D010750:Phosphoproteins; D012333:RNA, Messenger; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; D015678:Viral Structural Proteins; C085210:W protein, Newcastle disease virus