Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia.
zeta and eta chains of the T cell antigen receptor (TCR) complex and the gamma chain of Fc receptors (FcR gamma) constitute a family of proteins important for the expression of, and signal transduction through, these receptors in hematopoietic cells. In zeta-deficient mice, TCR expression was reduced in most T cells. By contrast, CD8 alpha alpha + TCR-gamma/delta + intestinal intraepithelial lymphocytes in these mice expressed a normal level of TCR. Biochemical analysis of the TCR complex in these cells from zeta-deficient as well as normal mice revealed the predominant usage of FcR gamma. Furthermore, gamma/delta + T cells in epithelia of the skin and female reproductive organs from zeta-deficient mice also showed relatively high TCR expression, indicating the usage of FcR gamma. These observations demonstrate the preferential usage of FcR gamma by gamma/delta + T cells localized in epithelia of normal mice.
Ohno
H
H
Division of Molecular Genetics, Chiba University School of Medicine, Japan.
Ono
S
S
Hirayama
N
N
Shimada
S
S
Saito
T
T
D000818:Animals; D002478:Cells, Cultured; D004848:Epithelium / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006825:Hybridomas; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011233:Precipitin Tests; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D011961:Receptors, Fc / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D016692:Receptors, Antigen, T-Cell, gamma-delta; D011961:Receptors, Fc