Significance of epidermal growth factor receptor expression in primary human endometrial cancer.
Radioreceptorial assessment of EGFR expression was prospectively performed on 60 primary human endometrial tumors. Of these, 26 were EGFR-positive while 13 expressed high EGFR levels. High EGFR levels correlated well with poor histopathological grading. No correlation with histopathological type, stage, myometrial invasion, lymph-node involvement or steroid hormone receptor status was observed. Disease-free survival rate was significantly shorter in the cases with high than in the cases with low EGFR levels. These results suggest a potential role of EGFR expression assessment in prognostic characterization of endometrial cancer patients.
Scambia
G
G
Department of Gynecology/Obstetrics, Catholic University, Rome, Italy.
Benedetti Panici
P
P
Ferrandina
G
G
Battaglia
F
F
Distefano
M
M
D'Andrea
G
G
De Vincenzo
R
R
Maneschi
F
F
Ranelletti
F O
FO
Mancuso
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015993:Life Tables; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011869:Radioligand Assay; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D016019:Survival Analysis
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D066246:ErbB Receptors