title: Effect of intermittent delivery of fluoride to solution on root hard-tissue de- and remineralization measured by 125I absorptiometry.
abstract: The effect of intermittent fluoride levels on root hard-tissue de- and remineralization was studied once daily for 21 days in a pH-cycling caries model with simulated fluoride clearance curves. Four root hard-tissue blocks, from each of 12 human teeth, were cut out parallel to the cementum surface. During a daily 15-hour period, the blocks were subjected 12 times to pH changes similar to those which occur in plaque after a carbohydrate intake. The fluoride was delivered immediately before a daily nine-hour remineralization period. Four experiments were independently carried out: One block from each tooth was subjected to pH-cycling without and with fluoride delivery, simulating a rinse with 0.025, 0.2, and 1.0% sodium fluoride (NaF), respectively. The mineral change in the blocks was monitored by 125I absorptiometry and expressed as the change in transmission (delta T). The surface between the data points (delta T values) and the x axis (time points) was used as a summary measure, i.e., the area under the curve (AUC). When no fluoride was delivered, the delta T increased over 21 days, indicating loss of mineral. The AUC was, on average, 5.85 +/- 0.68 (mean +/- S.E.) %.day. In the 0.025% NaF-rinse experiment, there was a marked reduction in mineral loss, indicated by an average AUC of 1.66 +/- 0.59%.day. In both the 0.2 and 1.0% NaF-rinse experiments, a decrease in delta T, indicating gain of mineral, was observed from day 2. Negative delta T values occurred after 7 and 3 days, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cariology, Karolinska Institutet, School of Dentistry, Huddinge, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Almqvist
authors.forename: F
authors.initials: F
authors.lastname: Lagerlöf
mesh_terms: D000704:Analysis of Variance; D003739:Dental Cementum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D003804:Dentin / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D016014:Linear Models; D009067:Mouthwashes / Q000008:administration & dosage; D011877:Radionuclide Imaging; D017213:Root Caries / Q000517:prevention & control*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D017001:Tooth Demineralization / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D014089:Tooth Remineralization; D014092:Tooth Root / Q000187:drug effects / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D007457:Iodine Radioisotopes; D009067:Mouthwashes; D012969:Sodium Fluoride