title: Short-term versus long-term addition of cyproterone acetate to buserelin therapy in comparison with orchidectomy in the treatment of metastatic prostate cancer. European Organization for Research and Treatment of Cancer--Genitourinary Group.
abstract: In an open, multicenter, three-armed, randomized study, we compared the effects of short-term (2 weeks) and continuous addition of the antiandrogen cyproterone acetate to the luteinizing hormone-releasing hormone agonist buserelin to those of orchidectomy in patients with advanced prostate cancer. No significant differences among the three treatment arms with respect to response rate, subjective response, time-to-progression, overall survival, and cancer deaths were observed. It was concluded that the short-term or continuous addition of cyproterone acetate to buserelin administered intranasally did not improve treatment results compared to orchidectomy only.
authors.affiliation: Department of Medical Oncology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Klijn
authors.forename: H J
authors.initials: HJ
authors.lastname: de Voogt
authors.forename: U E
authors.initials: UE
authors.lastname: Studer
authors.forename: F H
authors.initials: FH
authors.lastname: Schröder
authors.forename: R
authors.initials: R
authors.lastname: Sylvester
authors.forename: M
authors.initials: M
authors.lastname: De Pauw
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002064:Buserelin / Q000008:administration & dosage; D017373:Cyproterone Acetate / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D017373:Cyproterone Acetate; D002064:Buserelin