Nude mouse interim host model for human parathyroid grafts. Part IV. Human PTG xenograft rejection in a mouse B lymphocyte system.
An interim host model for human parathyroid gland (PTG) grafts has been established. In this experiment, the proliferation of mouse blood vessels and infiltration of mouse B lymphocytes into human PTG grafts were successively observed. The results showed that within 10 d of interim hosting, when PTG grafts were still nourished by permeable factors, scattered mouse B lymphocyte infiltration was already apparent. As time went by, B lymphocyte infiltration and IgG secretion became more obvious. At 60-90 d interim hosting, an intact human-mouse tissue "chimera" was formed. Thereafter, human PTG grafts were gradually fragmented and absorbed. The theoretical significance and clinical value of this rejection phenomenon are discussed.
Gao
Z
Z
PUMC Hospital, CAMS, Beijing.
Zhu
Y
Y
Tang
W
W
Li
D
D
Ye
S
S
D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology*; D001402:B-Lymphocytes / Q000166:cytology*; D002452:Cell Count; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010280:Parathyroid Glands / Q000276:immunology* / Q000637:transplantation*; D013370:Subrenal Capsule Assay; D014183:Transplantation, Heterologous