title: Simultaneous gastroesophageal pH monitoring and the diagnosis of alkaline reflux.
abstract: The diagnosis of alkaline gastroesophageal reflux (AGER) by esophageal pH-monitoring is elusive because several other causes may raise esophageal pH above 7. This study approaches the issue by simultaneously recording esophageal and gastric pH with a 2.1 mm assembly of two antimony electrodes in refluxing (n = 69) and nonrefluxing (n = 40) children. On the basis of the information gathered, patients were divided into four groups: acid refluxers (GER, n = 40 or 57%), alkaline refluxers (AGER, n = 8 or 11%), alkalacid refluxers (AAGER, n = 15 or 22%), and silent refluxers or false negatives (SGER, n = 6 or 9%). Children with AGER could not be differentiated from other refluxers nor from controls by esophageal pH information alone. Prolonged gastric buffering or alkalinization could be documented in both AGER and AAGER children, indicating extended duodenogastric reflux (DGR) in them. The incidence of esophagitis was not significantly different between the groups of refluxers: 75% for AGER and AAGER, 73% for GER, and 67% for SGER. AGER, a disorder involving both pyloric and gastroesophageal barriers, is as significant a problem in children as in adults and may lead to severe complications even in the absence of excessive acid exposure. Monitoring esophageal pH alone is insufficient for making the diagnosis of AGER. The diagnosis can be made with little more expense and similar patient discomfort using the two-probe test. We suggest the need for a critical reassessment of the current antacid and prokinetic GER treatments and of antireflux operations which leave DGR intact while correcting GER.
authors.affiliation: Universidad del País Vasco, Hospital Infantil Na Sa de Aranzazu, San Sebastián, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Tovar
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: I
authors.initials: I
authors.lastname: Eizaguirre
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology; D004947:Esophagus / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D007223:Infant; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D013030:Spain / Q000453:epidemiology; D013270:Stomach / Q000503:physiopathology*