title: Developmentally regulated processing and replication of the Tetrahymena rDNA minichromosome.
abstract: The ribosomal DNA locus of Tetrahymena thermophila undergoes a dramatic series of developmentally regulated processing events to generate the amplified rDNA minichromosome during formation of the somatic macronucleus. DNA transformation and classical genetic approaches have identified cis-acting elements that regulate rDNA processing in the developing macronucleus and subsequent vegetative rDNA maintenance.
authors.affiliation: Department of Microbiology and Immunology, University of California, San Francisco 94143.
authors.forename: G M
authors.initials: GM
authors.lastname: Kapler
mesh_terms: D000818:Animals; D002875:Chromosomes; D004261:DNA Replication; D016054:DNA, Protozoan / Q000096:biosynthesis; D004275:DNA, Ribosomal / Q000096:biosynthesis*; D016808:Tetrahymena thermophila / Q000235:genetics* / Q000254:growth & development
chemical_list: D016054:DNA, Protozoan; D004275:DNA, Ribosomal