title: Pharmacologic enhancement of random skin flap survival by prostaglandin E2.
abstract: This study evaluated the effect of prostaglandin E2 on skin flap survival in the porcine model. Dorsal random skin flaps on hypopigmented 15- to 25-kg pigs were used. Prostaglandin E2 (10 ng/kg per minute) was infused for 2 days prior to surgery and continued during the 7-day postoperative period. Mean flap survival was 52.58% +/- 3.62% for the control group and 68.51% +/- 3.34% for the experimental group (P < .05). A moderate correlation existed between prostaglandin E2 serum levels and flap viability. A strong correlation was noted between red blood cell flexibility and the amount of flap survival (r = .86). As red blood cell flexibility increased, the survival percentage also increased. Although prostaglandin E2 reduced adenosine diphosphate-induced platelet aggregation from a baseline of 86.08% +/- 8.33% to 54.61% +/- 17.21%, no correlation was noted between the amount of platelet aggregation and percent flap survival (r = .52).
authors.affiliation: Department of Pharmacology, Eastern Virginia Medical School, Norfolk.
authors.forename: C T
authors.initials: CT
authors.lastname: Layton
authors.forename: P B
authors.initials: PB
authors.lastname: Williams
authors.forename: D B
authors.initials: DB
authors.lastname: Hankins
authors.forename: T
authors.initials: T
authors.lastname: Phan
authors.forename: J H
authors.initials: JH
authors.lastname: Key
authors.forename: M F
authors.initials: MF
authors.lastname: Pratt
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D004907:Erythrocyte Deformability / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D016038:Skin Transplantation; D013524:Surgical Flaps; D013552:Swine
chemical_list: D010975:Platelet Aggregation Inhibitors; D015232:Dinoprostone