Phenytoin recovery from percutaneous endoscopic gastrostomy Pezzer catheters after long-term in vitro administration.
Four in vitro administration techniques were evaluated to determine which method would produce the least amount of phenytoin lost with long-term (14 days) dosing of Dilantin Kapseals (100 mg) or Dilantin suspension 125 mg/5 mL (92 mg) through 20 French percutaneous endoscopic gastrostomy Pezzer catheters. The four in vitro techniques were (1) no dilution or irrigation, (2) irrigation with 10 mL of deionized water, (3) dilution with 10 mL of deionized water, and (4) dilution with irrigation. Similar doses and volumes (3.68 mL) of suspension and capsules were delivered to three separate catheters for each method every 8 hours for 14 days. Each catheter was encased in a 200-mm glass water jacket and maintained at 37 degrees C for the entire 14 days. Samples were collected 1 hour after administration on days 1, 3, 7, 10, and 14 and analyzed by high-performance liquid chromatography. The total mean percent change in initial phenytoin for each method was as follows (S = suspension, K = Kapseals, subscript number = method number): S1, -4.23 +/- 20.20 (mean +/- SD); S2, -7.63 +/- 14.04; S3, -0.14 +/- 2.31; S4, 3.33 +/- 5.59; K1, -9.72 +/- 4.60, K2, 1.43 +/- 3.90; K3, -3.18 +/- 5.59; and K4, 1.39 +/- 4.57.(ABSTRACT TRUNCATED AT 250 WORDS)
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Section of Pharmacy Practice, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
McGoodwin
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Allen
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D002214:Capsules; D002404:Catheterization / Q000295:instrumentation; D020776:Endoscopes, Gastrointestinal; D005774:Gastrostomy / Q000295:instrumentation*; D006801:Humans; D010672:Phenytoin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013535:Suspensions; D007507:Therapeutic Irrigation
D002214:Capsules; D013535:Suspensions; D010672:Phenytoin