title: [Gonadotropes].
abstract: A pulsatile pattern of GnRH release by GnRH pulse generator in the hypothalamus is required for the maintenance of gonadotrope responses, Gn-subunit mRNA production and release of Gn. GnRH causes up-and down-regulation of GnRH receptors and desensitization of Gn-release. Gn-synthesis and release are modulated by gonadal steroid and peptide hormone through the hypothalamus and/or pituitary.
authors.forename: T
authors.initials: T
authors.lastname: Yaginuma
mesh_terms: D000818:Animals; D015536:Down-Regulation; D004967:Estrogens / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000378:metabolism*; D011374:Progesterone / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011966:Receptors, LHRH / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D004967:Estrogens; D006062:Gonadotropins; D012333:RNA, Messenger; D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone