The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13.
The leukemia inhibitory factor receptor (LIFR) gene was localized to human chromosome 5p12-p13 by somatic cell hybrid analysis. Interspecific backcross analysis revealed that the murine locus was on chromosome 15 in a region of homology with human chromosome 5p. In both human and mouse genomes, the LIFR locus was linked to the genes encoding the receptors for interleukin-7, prolactin, and growth hormone.
Gearing
D P
DP
Immunex Research and Development Corporation, Seattle, Washington 98101.
Druck
T
T
Huebner
K
K
Overhauser
J
J
Gilbert
D J
DJ
Copeland
N G
NG
Jenkins
N A
NA
D000818:Animals; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D013006:Growth Hormone / Q000235:genetics; D006131:Growth Inhibitors; D006801:Humans; D006822:Hybrid Cells; D015850:Interleukin-6; D015851:Interleukin-7 / Q000235:genetics; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008222:Lymphokines / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D005810:Multigene Family; D011388:Prolactin / Q000235:genetics; D018121:Receptors, Cytokine / Q000235:genetics*; D053606:Receptors, OSM-LIF
D006131:Growth Inhibitors; D015850:Interleukin-6; D015851:Interleukin-7; C507837:LIF protein, human; C507840:LIFR protein, human; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; C507838:Lif protein, mouse; C507841:Lifr protein, mouse; D008222:Lymphokines; D018121:Receptors, Cytokine; D053606:Receptors, OSM-LIF; D011388:Prolactin; D013006:Growth Hormone