Colchicine in diabetes mellitus.
As anti-inflammatory drugs such as acetylsalicylic acid are known to partially restore insulin response to glucose, the possible beneficial effect of colchicine, an anti-gout and anti-inflammatory drug, in non-insulin dependent diabetes mellitus (NIDDM) was studied. Colchicine could significantly reduce blood glucose levels, both fasting and post-prandial when given at a dose of 0.5 mg thrice a day in NIDDM patients. There were no side-effects due to the therapy. This study suggests that colchicine has anti-diabetic properties.
Das
U N
UN
Department of Medicine, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad.
D001786:Blood Glucose / Q000187:drug effects*; D003078:Colchicine / Q000008:administration & dosage*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D005215:Fasting; D006801:Humans
D001786:Blood Glucose; D003078:Colchicine