Photodynamic activity of liposome-delivered Cd-texaphyrin using tumor-bearing nude mice.
Photodynamic effects in bladder-tumor bearing nude mice induced by a krypton ion laser (752.5 nm) after i.v. application of liposome-delivered cadmium texaphyrin were investigated. Cd-texaphyrin possesses strong absorption transitions in the far red spectral region (around 760 nm) and a high quantum efficiency of singlet oxygen production. No therapeutic effects were obtained using irradiation 24 hours after administration of the sensitizer, whereas phototreatment 2 hours after application led to significant tumor reduction. This corresponds well with studies on fluorophore-labeled liposomes indicating highest tumor accumulation 1-2 hours after administration. However, the induced cytotoxic effects were lower than those of HpD.
König
K
K
Institut für Lasertechnologien, Universität Ulm, Germany.
Genze
F
F
Miller
K
K
Rück
A
A
Reich
E
E
Repassy
D
D
D000818:Animals; D005260:Female; D006415:Hematoporphyrins / Q000008:administration & dosage; D053685:Laser Therapy; D008081:Liposomes; D008665:Metalloporphyrins / Q000008:administration & dosage*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
D006415:Hematoporphyrins; D008081:Liposomes; D008665:Metalloporphyrins; C084914:cadmium texaphyrin