Effect of calcium channel blockers and salbutamol on oxytocin and PGF2 alpha induced uterine contractions in rats.
Calcium channel blockers verapamil (2, 10nM), diltiazem (11, 22nM), nifedipine (2.9, 14nM) and salbutamol (21, 42nM) produced concentration dependent inhibition of oxytocin induced contractions in non-pregnant rats. With verapamil and nifedipine the effect was more marked at both low and high doses. Verapamil (1,2nM), diltiazem (2.2, 11nM), nifedipine (1.4, 2.9nM) and salbutamol (2.1, 4.2nM) produced significant inhibitory effect on PGF2 alpha (0.3 microgram) induced phasic tension. However, basal tension was significantly reduced by salbutamol and nifedipine only.
Sharma
S
S
Department of Pharmacology, Maulana Azad Medical College, New Delhi, India.
Gupta
U
U
D000420:Albuterol / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015237:Dinoprost / Q000037:antagonists & inhibitors*; D005260:Female; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D014590:Uterine Contraction / Q000187:drug effects*
D002121:Calcium Channel Blockers; D010121:Oxytocin; D015237:Dinoprost; D000420:Albuterol