title: Usefulness of a multiple biomarker assay in bronchoalveolar lavage (BAL) and serum for the diagnosis of small cell lung cancer.
abstract: To evaluate the diagnostic usefulness of simultaneous determinations of carcinoembryonic antigen (CEA), neuron specific enolase (NSE), chorionic gonadotrophin (HCG) and carbohydrate antigenic determinant 19-9 (CA 19-9), we studied 48 patients with small cell lung carcinoma (SCLC) and 15 with nonmalignant lung disease. The combination of CEA-BAL, NSE-BAL, and NSE-serum taken together with results of bronchoscopy (histologic and cytologic) showed the highest discriminating power between malignant (SCLC) and nonmalignant lung disease. The sensitivity of bronchoscopy alone was 35%. However, when bronchoscopy results were combined with 3 positive markers, the sensitivity increased to 71%, with at least 2 positive markers to 94%, and with at least 1 positive marker to 100%. When both bronchoscopy and all 3 markers were negative, the results showed a negative predictive value of 100%.
authors.affiliation: Department of Thoracic Surgery, Medical School, Białystok, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Nikliński
authors.forename: E
authors.initials: E
authors.lastname: Chyczewska
authors.forename: M
authors.initials: M
authors.lastname: Furman
authors.forename: E
authors.initials: E
authors.lastname: Kowal
authors.forename: J
authors.initials: J
authors.lastname: Laudanski
authors.forename: L
authors.initials: L
authors.lastname: Chyczewski
mesh_terms: D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D001999:Bronchoscopy; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000097:blood; D018288:Carcinoma, Small Cell / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000097:blood; D003937:Diagnosis, Differential; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000097:blood
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D010751:Phosphopyruvate Hydratase