Is ANP responsible for the hemoconcentration in preeclampsia?
A hypothesis is presented that high plasma concentration of alpha-human Atrial Natriuretic Peptide (ANP) might be responsible for hemoconcentration of preeclampsia (PE), mediated by increased diuresis and shift of fluid to the interstitium. ANP is known as a peptide regulating blood volume by diuresis and natriuresis, and perhaps through increased permeability in vessels. Moreover ANP is an antagonist to the renin-angiotensin-aldosterone (RAA) system, especially when this system is activated quantitatively as in pregnancy or qualitatively as in PE.
Poulsen
H
H
Department of Obstetrics and Gynecology, University of Lund, General Hospital, Malmö, Sweden.
Sthjernquist
M
M
Sjöberg
N O
NO
D009320:Atrial Natriuretic Factor / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology; D004231:Diuresis / Q000502:physiology; D005260:Female; D006801:Humans; D008955:Models, Cardiovascular; D009318:Natriuresis / Q000502:physiology; D010953:Plasma Volume / Q000502:physiology*; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D012084:Renin-Angiotensin System / Q000502:physiology
D009320:Atrial Natriuretic Factor