Periodic bursting of cultured cortical neurons in low magnesium: cellular and network mechanisms.
The origin of the 0.1 Hz bursting of cultured rat cortical neurons in zero Mg2+ was studied by whole-cell recording, fluo-3 Ca2+ imaging, and multi-unit electrode array recording. A model is proposed in which spontaneous synaptic currents act as a random pacemaker.
Robinson
H P
HP
Material Science Laboratory, NTT Basic Research Laboratories, Tokyo, Japan.
Torimitsu
K
K
Jimbo
Y
Y
Kuroda
Y
Y
Kawana
A
A
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D004566:Electrodes; D004594:Electrophysiology; D008274:Magnesium / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013569:Synapses / Q000502:physiology
D015220:Calcium Channels; D016194:Receptors, N-Methyl-D-Aspartate; D008274:Magnesium