title: Trabeculectomy with 5-fluorouracil vs single-plate Molteno implantation.
abstract: We compared the results achieved in 22 consecutive patients who underwent single-plate Molteno implantation, with those achieved in a matched group who had trabeculectomy with postoperative 5-fluorouracil. Six months following surgery, the average intraocular pressure (IOP) in the Molteno group was 15.4 +/- 8.0 mm Hg, and in the trabeculectomy group, 16.1 +/- 5.6 mm Hg (P = .920). A mean of 1.4 antiglaucoma medications were being used in each group (P = .776). Complications following Molteno implantation included six tube revisions and three flat anterior chambers; following trabeculectomy, eight serous choroidal detachments and nine positive Seidel tests. This study suggests that Molteno implantation and trabeculectomy with adjunctive 5-fluorouracil provide similar IOP control, but that the two procedures are associated with different types of complications.
authors.affiliation: Department of Ophthalmology, Medical University of South Carolina, Charleston 29425-2236.
authors.forename: E C
authors.initials: EC
authors.lastname: Bluestein
authors.forename: W C
authors.initials: WC
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D019736:Prostheses and Implants; D012826:Silicone Elastomers; D014130:Trabeculectomy; D014792:Visual Acuity
chemical_list: D012826:Silicone Elastomers; D005472:Fluorouracil