A morphological biosensor for mammalian cells.
An electrical biosensor is described that can continuously track morphological changes of adherent cells providing quantitative data from both sparse and confluent cultures. The method is capable of detecting vertical motion of cells of the order of 1 nm, much below the resolution of an optical microscope.
Giaever
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School of Science, Rensselaer Polytechnic Institute, Troy, New York 12180-3590.
Keese
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CR
D000230:Adenocarcinoma; D000818:Animals; D015374:Biosensing Techniques; D002417:Cattle; D002448:Cell Adhesion; D002465:Cell Movement; D002478:Cells, Cultured / Q000166:cytology* / Q000502:physiology*; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D008264:Macrophages / Q000166:cytology / Q000502:physiology; D008297:Male; D008322:Mammals; D051379:Mice; D011471:Prostatic Neoplasms; D051381:Rats; D014407:Tumor Cells, Cultured