[Tumor necrosis factor alpha in IgA nephropathy].
Tumor necrosis factor alpha (TNF alpha) in serum and supernate of peripheral blood lymphocyte stimulated by PHA in 100 cases of IgA nephropathy (IgAN) was evaluated by means of ELISA with TNF alpha monoclone antibody (T5 & E6). The results show that TNF alpha content in serum and supernatant was significantly higher in IgAN than in control (P < 0.01), and was increased markedly in IgAN with sclerosis (P < 0.01). It suggests that TNF alpha play an important role in cellular immunity of IgA nephropathy.
Yu
L F
LF
Department of Nephrology, General Hospital of Chinese PLA, Beijing.
Chen
X M
XM
Bo
L Q
LQ
D000328:Adult; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha