[Concentrations of propofol in maternal and fetal blood during anesthesia for cesarean section].
The authors studied, until the delivery, the pharmacokinetics of propofol during cesarean section. Ten patients were studied. Anaesthesia was induced and maintained with propofol (2 mg/kg in 15 seconds; 3 mg/kg/h until the end of the operation). All the patients have been intubated after the administration of atracurium 0.4 mg/kg and artificially ventilated with O2/N2O (FiO2 0.4). A series of maternal blood samples was obtained. Umbilical artery and venous blood samples have been obtained at delivery. Propofol levels in whole blood samples have been measured by a HPLC method (High pressure liquid chromatography). The results were: at delivery the mean ratio of the drug concentration in the umbilical vein to that in maternal vein was 0.53 +/- 0.16 micrograms/ml; the mean concentration in the umbilical vein was 0.96 +/- 0.31 micrograms/ml. The anaesthesiological protocol was clinically satisfactory and had no adverse effects on mother and foetus.
Audibert
G B
GB
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Catania.
Bulla
G
G
Di Bono
G
G
Palazzo
G
G
Romano
G
G
Vaccaro
G
G
Zagami
A
A
D000293:Adolescent; D000328:Adult; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D015742:Propofol / Q000097:blood*
D015742:Propofol
Concentrazioni di propofol nel sangue materno e fetale in corso di anestesia per taglio cesareo.