Methylphenidate increases thought disorder in recent onset schizophrenics, but not in normal controls.
The effects of apomorphine and methylphenidate on thought disorder, as measured by the Thought Disorder Index, in schizophrenic patients and in normal controls were evaluated. Methylphenidate, but not apomorphine, increased thought disorder in patients. Neither drug significantly increased thought disorder in controls.
Levy
D L
DL
McLean Hospital, Belmont, MA 02178.
Smith
M
M
Robinson
D
D
Jody
D
D
Lerner
G
G
Alvir
J
J
Geisler
S H
SH
Szymanski
S R
SR
Gonzalez
A
A
Mayerhoff
D I
DI
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D013850:Thinking / Q000187:drug effects* / Q000502:physiology
D008774:Methylphenidate; D001058:Apomorphine; D004298:Dopamine