title: Normal activation of frontotemporal language cortex in dyslexia, as measured with oxygen 15 positron emission tomography.
abstract: OBJECTIVE
  To assess the ability of dyslexic men to activate left middle to anterior language cortex normally.
  
  
  METHODS
  Positron emission tomography using oxygen 15-labeled water as a tracer during rest and during a syntax task involving sentence comprehension.
  
  
  METHODS
  Research hospital.
  
  
  METHODS
  Fifteen right-handed, severely dyslexic men (mean [+/- SD] age, 27 +/- 5 years) and 20 matched controls.
  
  
  METHODS
  None.
  
  
  METHODS
  Cerebral blood flow.
  
  
  RESULTS
  During rest, dyslexics showed reduced blood flow (relative to controls) in one left parietal region near the angular/supramarginal gyri, but otherwise normal flow. During syntactic processing, dyslexics and controls showed similar, significant activation of left middle to anterior temporal and inferior frontal cortex.
  
  
  CONCLUSIONS
  These results, together with the previously reported failure of dyslexics to activate left temporoparietal cortex during phonologic processing, argue for dysfunction of left cortical language areas restricted to posterior language regions in dyslexia.
authors.affiliation: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Md.
authors.forename: J M
authors.initials: JM
authors.lastname: Rumsey
authors.forename: A J
authors.initials: AJ
authors.lastname: Zametkin
authors.forename: P
authors.initials: P
authors.lastname: Andreason
authors.forename: A P
authors.initials: AP
authors.lastname: Hanahan
authors.forename: S D
authors.initials: SD
authors.lastname: Hamburger
authors.forename: T
authors.initials: T
authors.lastname: Aquino
authors.forename: A C
authors.initials: AC
authors.lastname: King
authors.forename: A
authors.initials: A
authors.lastname: Pikus
authors.forename: R M
authors.initials: RM
authors.lastname: Cohen
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D004410:Dyslexia / Q000503:physiopathology*; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D010104:Oxygen Radioisotopes; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014055:Tomography, Emission-Computed; D014888:Wechsler Scales
chemical_list: D010104:Oxygen Radioisotopes