A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family.
A 1.4-kb full-length cDNA was isolated from a library constructed from activated human T-cell leukemia virus type 1-transformed human T-lymphocytes. Sequence analysis identified this cDNA as a new member of the human nerve-growth-factor receptor/tumor-necrosis-factor receptor family and as the potential human homologue of the murine sequence, 4-1BB. The gene encodes three cysteine-rich motifs in the extracellular domain which are characteristic of this receptor family, a transmembrane region and a short N-terminal cytoplasmic portion which contains potential phosphorylation sites.
Schwarz
H
H
Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093-0663.
Tuckwell
J
J
Lotz
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D008969:Molecular Sequence Data; D018121:Receptors, Cytokine / Q000032:analysis / Q000235:genetics*; D017475:Receptors, Nerve Growth Factor / Q000235:genetics; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*
C084945:ILA receptor; D018121:Receptors, Cytokine; D017475:Receptors, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor; D004247:DNA