title: Enhancement of the antitrichomonal activity of 5-nitroimidazole derivatives by hydrogen peroxide.
abstract: The in vitro sensitivity of nine Trichomonas vaginalis isolates to commonly employed 5-nitroimidazoles (metronidazole, nimorazole, ornidazole and tinidazole) was evaluated in absence and in presence of sub-inhibitory concentrations of hydrogen peroxide (H2O2). Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the strains exhibiting cross-resistance to these drugs. It was suggested that H2O2 produced in the inflammatory process during trichomonal infection could enhance the therapeutic effect of 5-nitroimidazole drugs.
authors.affiliation: Istituto di Chimica Biologica, Facoltà di Farmacia, Università di Sassari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mattana
authors.forename: C
authors.initials: C
authors.lastname: Juliano
authors.forename: V
authors.initials: V
authors.lastname: Picci
authors.forename: F
authors.initials: F
authors.lastname: Franconi
authors.forename: P
authors.initials: P
authors.lastname: Cappuccinelli
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000994:Antitrichomonal Agents; D009593:Nitroimidazoles; D006861:Hydrogen Peroxide