Protein tyrosine kinase activity as a prognostic parameter in breast cancer, a pilot study.
Protein tyrosine kinase (PTK) activity was assayed in cytosolic extracts from normal breast tissue, benign tumors, and 84 T1-T2, N0-N1 M0, breast carcinomas. Normal breast tissue extracts yielded an average value of 1.9 +/- 1.1 pmol 32P incorporated/min/mg protein, whereas a mean of 12.5 +/- 6.1 was obtained for cancer samples. With a median follow-up of 34 months, in the series of 40 patients classified N-, PTK positive patients presented a significantly smaller 3-year disease free survival than the PTK negative ones. Multivariate analysis shows that PTK activity emerges as a potential prognostic factor in breast cancer (p = 0.02). These preliminary results will be updated on a bigger cohort of patients.
Bolla
M
M
Biochemistry Department, CHU A. Michallon, Grenoble, France.
Rostaing-Puissant
B R
BR
Chedin
M
M
Souvignet
C
C
Marron-Charriere
J
J
Colonna
M
M
Berland
E
E
Chambaz
E M
EM
D000328:Adult; D000368:Aged; D001940:Breast / Q000201:enzymology; D001943:Breast Neoplasms / Q000201:enzymology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008875:Middle Aged; D010761:Phosphorus Radioisotopes; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011379:Prognosis; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013223:Statistics as Topic
D010761:Phosphorus Radioisotopes; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011505:Protein-Tyrosine Kinases