Hydroxyurea and lower leg ulcers.
We report four cases of cutaneous lower leg ulcers associated with hydroxyurea treatment for myeloproliferative disorders. This association has been reported in one other series of patients who had chronic myelogenous leukemia and were treated with hydroxyurea. A review of the literature and survey of possible pathogenetic mechanisms is presented.
Nguyen
T V
TV
Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia 19104-4283.
Margolis
D J
DJ
D000368:Aged; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D007871:Leg Ulcer / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000188:drug therapy; D055728:Primary Myelofibrosis / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D013922:Thrombocytosis / Q000188:drug therapy
D006918:Hydroxyurea