Lipid peroxidation. Biopathological significance.
Peroxidation of unsaturated lipids, initially studied in the chemistry of oil and fat rancidity, has become a problem of increasing interest in the biological field, because of its proposed role in a variety of pathological conditions. The general mechanism of the process, the formation of toxic aldehydes capable to react with protein and non protein thiols, and the overall effects in cellular membranes are reviewed. The possible implications of lipid peroxidation as one of the main mechanisms of cellular damage in both toxic injury and other pathological conditions are discussed.
Comporti
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Instituto di Pathologia Generale, Università di Siena, Italy.
D000447:Aldehydes; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D002477:Cells / Q000473:pathology; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D011506:Proteins / Q000378:metabolism
D000447:Aldehydes; D005231:Fatty Acids, Unsaturated; D011506:Proteins