title: Serum lipoprotein (a) in renal transplant recipients receiving cyclosporin monotherapy.
abstract: Coronary heart disease is more common in patients with chronic renal failure and is a major cause of death after renal transplantation. Elevated serum lipoprotein (a) (Lp(a)) is a known risk factor for coronary heart disease in the general population. We measured the serum concentration of Lp(a) in 58 renal transplant recipients (40 male, 18 female) on cyclosporin monotherapy, and in 58 age- and sex-matched controls. Serum Lp(a) was significantly elevated in the transplant patients with a median of 27.5 (range < 0.8-140.3) mg/dl compared to 7.6 (range < 0.8-87.4) mg/dl in controls (P < 0.001). Total serum cholesterol, low-density lipoprotein cholesterol, and total triglyceride concentrations were also significantly raised (P < 0.001) in the transplant recipients. The increased serum Lp(a) may contribute to the increased cardiovascular morbidity associated with renal transplantation.
authors.affiliation: Renal Unit, Manchester Royal Infirmary, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Brown
authors.forename: N
authors.initials: N
authors.lastname: Anwar
authors.forename: C D
authors.initials: CD
authors.lastname: Short
authors.forename: D
authors.initials: D
authors.lastname: Bhatnager
authors.forename: M I
authors.initials: MI
authors.lastname: Mackness
authors.forename: L P
authors.initials: LP
authors.lastname: Hunt
authors.forename: P N
authors.initials: PN
authors.lastname: Durrington
mesh_terms: D000328:Adult; D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D008055:Lipids; D017270:Lipoprotein(a); D016572:Cyclosporine