title: Effect of altering pump flow rate on cerebral blood flow and metabolism in infants and children.
abstract: The effects of reduced pump flow rate (PFR) on cerebral blood flow, cerebral oxygen consumption (CMRO2), oxygen extraction, cerebral vascular resistance, and total body vascular resistance were examined in 27 pediatric patients during hypothermic cardiopulmonary bypass (hCPB). During steady state hCPB the extracorporeal flows were randomly adjusted to a conventional PFR and a reduced PFR for each patient. The reduced pump flow rates were dictated by surgical needs. Cerebral blood flow measured using Xenon 133 clearance, and CMRO2 and oxygen extraction were calculated. Our results demonstrated that cerebral blood flow and CMRO2 are unchanged if pump flow rates are reduced by 35% to 45% of conventional PFRs at moderate and deep hypothermic temperatures. Reductions in PFR of 45%-70% from conventional PFRs affect the brain differently during either moderate or deep hCPB. At moderate hCPB (26 degrees to 29 degrees C), reductions in PFRs of 45% to 70% resulted in a significant decrease in cerebral blood flow and CMRO2, whereas oxygen extraction increased in a compensatory manner. During deep hCPB (18 degrees to 22 degrees C), PFR reductions of 45% to 70% of conventional PFR significantly reduced cerebral blood flow and CMRO2 but did not increase oxygen extraction, suggesting that at deep hypothermic temperatures, cerebral blood flow and CMRO2 exceed cerebral metabolic needs. Cerebral vascular resistance increased significantly with decreasing temperature but was not affected by pump flow reductions. We have derived indices for minimal acceptable low-flow cardiopulmonary bypass based on the known effects of temperature on cerebral metabolism and have speculated on its utility based on our limited data and a literature review.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: F H
authors.initials: FH
authors.lastname: Kern
authors.forename: R M
authors.initials: RM
authors.lastname: Ungerleider
authors.forename: J G
authors.initials: JG
authors.lastname: Reves
authors.forename: T
authors.initials: T
authors.lastname: Quill
authors.forename: L R
authors.initials: LR
authors.lastname: Smith
authors.forename: B
authors.initials: B
authors.lastname: Baldwin
authors.forename: N D
authors.initials: ND
authors.lastname: Croughwell
authors.forename: W J
authors.initials: WJ
authors.lastname: Greeley
mesh_terms: D000293:Adolescent; D001921:Brain / Q000378:metabolism*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005112:Extracorporeal Circulation / Q000379:methods*; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D007231:Infant, Newborn; D010101:Oxygen Consumption / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology