Accumulation of 2-deoxy-2[18F]fluoro-D-glucose in human cancers heterotransplanted in nude mice: comparison between histology and glycolytic status.
The success of tumor imaging with PET and 2-deoxy-2-fluoro[18F]-D-glucose (18FDG) is based on preferential accumulation of 18FDG in tumors.


METHODS
Fluorine-18-FDG uptake was measured in nine human cancers heterotransplanted in nude mice and compared with histologic subclassification.


RESULTS
Mean 18FDG uptake by the human cancers was considerably less than that by the host's heart, but values at 60 min after injection were about 2.5 times as high as the liver and kidney, about two times as that for the muscle and about six times that for the blood. Comparison of 18FDG uptake and histological grade in four gastric, two pancreatic and three colonic cancers showed that 18FDG uptake increased with loss of differentiation.


CONCLUSIONS
This nude mice model system is useful for studying correlations between physiological and morphological parameters of heterotransplanted human cancers.
Yoshioka
T
T
Department of Clinical Oncology, Tohoku University, Sendai, Japan.
Takahashi
H
H
Oikawa
H
H
Maeda
S
S
Wakui
A
A
Watanabe
T
T
Tezuka
F
F
Takahashi
T
T
Ido
T
T
Kanamaru
R
R
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004067:Digestive System Neoplasms / Q000378:metabolism* / Q000473:pathology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology
D003287:Contrast Media; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose