Chloracne--study of an outbreak with new clinical observations.
A recent outbreak of chloracne in 17 workers is reported at a plant manufacturing dichloroaniline derivatives. Comedones developed 6-12 weeks after accidental exposure to the chloracnegenic contaminants and were present in every case. Cutaneous xerosis and a folliculitis, previously only rarely described as manifestations of chloracne, were noted in half the patients. The pathogenesis of these lesions is uncertain but may involve a disorder of keratinization.
McDonagh
A J
AJ
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK.
Gawkrodger
D J
DJ
Walker
A E
AE
D000152:Acne Vulgaris / Q000139:chemically induced*; D000814:Aniline Compounds / Q000009:adverse effects*; D002617:Chemical Industry; D009783:Dermatitis, Occupational / Q000209:etiology*; D004196:Disease Outbreaks; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects*; D008297:Male; D016273:Occupational Exposure
D000814:Aniline Compounds; D006843:Hydrocarbons, Chlorinated