title: Striatonigral degeneration with neurofibrillary tangles.
abstract: An autopsy was performed on a 48-year-old woman with clinical features of parkinsonism-plus syndrome with dominating akinesia. Neuropathological examination revealed striato-nigral degeneration (SND) and neurofibrillary tangles (NFT) characterizing progressive supranuclear palsy. Such an unusual combination of pathological findings may constitute a distinct clinico-pathological entity, with akinesia as the main clinical symptom, and with a pathological substrate of SND and NFT. We suggest that such cases may establish a separate variant within multisystem atrophies syndromes.
authors.affiliation: Institute of Neurology, University Hospital of Nijmegen, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Renkawek
authors.forename: M W
authors.initials: MW
authors.lastname: Horstink
mesh_terms: D000328:Adult; D003342:Corpus Striatum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009069:Movement Disorders / Q000150:complications; D016874:Neurofibrillary Tangles / Q000473:pathology*; D009929:Organ Size / Q000502:physiology; D010300:Parkinson Disease / Q000473:pathology; D013378:Substantia Nigra / Q000473:pathology*; D013494:Supranuclear Palsy, Progressive / Q000150:complications / Q000473:pathology