Phagocytic activity in stressed mice: effects of alprazolam.
Mice exposed to a chronic auditory stressor and daily injected with alprazolam (1 mg/kg/day, s.c.) showed a reduction in stress-induced suppression of the in vitro and in vivo activity of phagocytosis, measured using the zymosan particle uptake method and the carbon clearance test, respectively. Pretreatment with Ro-15-1788 (10 mg/kg, s.c.), a central nervous system benzodiazepine antagonist, resulted in suppression of the effects of alprazolam in stressed mice.
Freire-Garabal
M
M
Neuroimmunology University of Santiago (NIMUS), Hospital Médico-Quirúrgico de Conxo, Santiago de Compostela, Spain.
Núñez
M J
MJ
Fernández-Rial
J C
JC
Couceiro
J
J
García-Vallejo
L
L
Rey-Méndez
M
M
D000525:Alprazolam / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002244:Carbon; D005260:Female; D005442:Flumazenil / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009622:Noise / Q000009:adverse effects*; D010587:Phagocytosis / Q000187:drug effects; D013312:Stress, Physiological / Q000188:drug therapy / Q000276:immunology*; D015054:Zymosan
D005442:Flumazenil; D002244:Carbon; D015054:Zymosan; D000525:Alprazolam