Confirmatory analysis of clenbuterol using two different derivatives simultaneously.
To meet the requirements of the European Community for confirmatory analysis of clenbuterol using low-resolution mass spectrometry, usually two different techniques (i.e. electron impact and chemical ionization) have to be applied to confirm unambiguously its presence in extracts of urine. This paper describes the application of two different derivatives and the simultaneous analysis of these two different derivatives in one gas chromatographic-mass spectrometric analysis. With the proposed combination of techniques, Community requirements can more easily be met in only one analytical run. Examples of the analysis of some urine samples are presented, as well as data on linearity, repeatability and equivalence of the combined technique to separate determinations.
van Rhijn
J A
JA
State Institute for Quality Control of Agricultural Products, Wageningen, Netherlands.
Traag
W A
WA
Heskamp
H H
HH
D002976:Clenbuterol / Q000031:analogs & derivatives / Q000032:analysis* / Q000652:urine; D004563:Electrochemistry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013058:Mass Spectrometry
D002976:Clenbuterol