Estrogen and androgen receptors in aorta of the rabbit and regulation by estrogen and androgen.
This study was designed to investigate the sexual and/or regional dimorphism of the effects of estrogens and androgens on the aorta. Estrogen, estradiol-17 beta (E2) and estriol (E3), or androgen, dihydrotestosterone (DHT) and testosterone (T), binding levels, and of effects of E2 and T on their levels were determined in aortas of the male and female rabbits. Priming with E2 affected estrogen binding levels of the male aorta, but the physiological condition with E2 plus T induced the levels of E2 and E3 receptors in the female aorta. DHT receptor level in the male was increased with E2 alone or with T, while a rise in T binding level was seen in the male and female primed with E2 and T. These findings suggest that there is a sexual and/or regional dimorphism in the actions of estrogen and androgen on their receptor synthesis in the aorta.
Tamaya
T
T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Misao
R
R
Nakagawa
M
M
Itoh
T
T
Wada
K
K
Fujimoto
J
J
Imai
A
A
D000728:Androgens / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D008297:Male; D011817:Rabbits; D011944:Receptors, Androgen / Q000187:drug effects / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism*; D012727:Sex Characteristics
D000728:Androgens; D004967:Estrogens; D011944:Receptors, Androgen; D011960:Receptors, Estrogen