title: Inhaled furosemide prevents ultrasonically nebulized water bronchoconstriction in children with both atopic and nonatopic asthma.
abstract: To determine whether inhaled furosemide can modify the bronchoconstriction induced by ultrasonically nebulized distilled water (UNDW) in children with both atopic and nonatopic asthma, a single-blind, randomized, placebo-controlled study was undertaken. The UNDW inhalation challenge was performed in 21 asthmatic children (atopic, 14; nonatopic, 7; mean +/- SEM age, 11.5 +/- 0.5 years), who had a fall in FEV1 of at least 20 percent after distilled water inhalation. On separate days, these subjects underwent UNDW challenge test after inhalation of furosemide (10 mg/body square meters) or placebo (saline solution). Inhaled furosemide exerted a protective effect against bronchoconstriction induced by UNDW in children with both atopic and nonatopic asthma (p < 0.01, p < 0.05, respectively). These results indicate that the protective action of furosemide against UNDW-induced bronchoconstriction may be independent of its direct inhibitory effect on airway mast cell activation.
authors.affiliation: Department of Pediatrics, Gunma University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Morikawa
authors.forename: T
authors.initials: T
authors.lastname: Kuroume
mesh_terms: D000280:Administration, Inhalation; D001249:Asthma / Q000150:complications / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects; D002648:Child; D005260:Female; D005665:Furosemide / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications*; D008297:Male; D009330:Nebulizers and Vaporizers; D016037:Single-Blind Method; D014465:Ultrasonics; D014867:Water / Q000008:administration & dosage*
chemical_list: D014867:Water; D005665:Furosemide