title: High serum soluble interleukin-2 receptor concentrations in elderly individuals and smokers.
abstract: The effects of sex, age, and smoking on the serum concentrations of soluble interleukin-2 receptor (sIL-2R) were investigated in 83 healthy subjects. No sex-related difference was found. The correlation between age and the serum sIL-2R concentration was weak, but significant, in the nonsmokers (r = 0.30, n = 50, p < 0.05). The serum sIL-2R concentration was significantly higher in smokers than in nonsmokers (41.0 +/- 2.8 pM (mean +/- SEM), n = 33, vs. 31.9 +/- 1.0, n = 50, p < 0.005). These results suggest that age and smoking habits should be taken into consideration when interpreting the serum sIL-2R concentration, although the mechanism by which sIL-2R concentrations are altered remains unknown at present.
authors.affiliation: Department of Medicine and Clinical Immunology, Dokkyo University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Motojima
authors.forename: A
authors.initials: A
authors.lastname: Hirata
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: S
authors.initials: S
authors.lastname: Makino
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012737:Sex Factors; D012907:Smoking / Q000097:blood*; D012995:Solubility
chemical_list: D015375:Receptors, Interleukin-2