title: Possible variation in bone resorption during the normal menstrual cycle.
abstract: In order to determine whether bone turnover varies during the normal menstrual cycle, we measured biochemical markers of bone resorption (serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (sICTP), fasting urinary hydroxyproline/creatinine, fasting urinary pyridinoline/creatinine and fasting urinary deoxypyridinoline/creatinine) and bone formation (plasma osteocalcin, serum carboxy-terminal propeptide of type I procollagen and serum alkaline phosphatase) in ten healthy premenopausal women every two or three days for a complete menstrual cycle. A cyclic pattern was detected in sICTP, with its nadir during the follicular phase and its peak during the luteal phase, and an overall variation of 17% during the menstrual cycle (p = 0.004). No cyclic changes were observed in the urinary parameters of bone resorption or in the biochemical markers of bone formation. We conclude that sICTP, a new biochemical marker of bone resorption, undergoes small variations during a normal menstrual cycle in premenopausal women, whereas the biochemical markers of bone formation remain constant.
authors.affiliation: Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Schlemmer
authors.forename: C
authors.initials: C
authors.lastname: Hassager
authors.forename: J
authors.initials: J
authors.lastname: Risteli
authors.forename: L
authors.initials: L
authors.lastname: Risteli
authors.forename: S B
authors.initials: SB
authors.lastname: Jensen
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D001862:Bone Resorption / Q000503:physiopathology*; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D003401:Creatine / Q000652:urine; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008597:Menstrual Cycle / Q000378:metabolism / Q000502:physiology*; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D017697:Premenopause / Q000502:physiology; D011347:Procollagen / Q000097:blood
chemical_list: D000596:Amino Acids; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; D004958:Estradiol; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen; D000469:Alkaline Phosphatase; D003401:Creatine; D006909:Hydroxyproline