Virus-like particles in synovial fluids from patients with rheumatoid arthritis.
Based on the elevated expression of oncogenes in proliferating transformed-appearing synoviocytes we searched for the possible involvement of a viral agent in the pathogenesis of RA. We report the detection of virus-like particles with retroviral C type morphology in SF, which lack the typical morphologic as well as immunohistochemical features of the human T-lymphotropic and immunodeficiency viruses.
Stransky
G
G
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham.
Vernon
J
J
Aicher
W K
WK
Moreland
L W
LW
Gay
R E
RE
Gay
S
S
D001172:Arthritis, Rheumatoid / Q000382:microbiology* / Q000473:pathology; D002460:Cell Line; D002478:Cells, Cultured; D005347:Fibroblasts / Q000382:microbiology; D006801:Humans; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D013582:Synovial Fluid / Q000382:microbiology*; D013583:Synovial Membrane / Q000382:microbiology / Q000473:pathology; D014771:Virion / Q000302:isolation & purification*