The effects of d- and l-fenfluramine (and their interactions with d-amphetamine) on cortisol secretion.
Twelve normal weight healthy male volunteers participated in a double-blind, placebo-controlled trial of the effects of d- and l-fenfluramine, d-amphetamine, and the interactions between the two isomers of fenfluramine with amphetamine, on cortisol secretion. d-Fenfluramine and d-amphetamine in combination produced the greatest cortisolaemic effect, suggesting that they act by differing neurochemical pathways. d-Fenfluramine produced a significant effect, but l-fenfluramine produced little effect, suggesting that the cortisol-releasing properties of racemic fenfluramine reside in the d-isomer.
Feeney
S
S
Academic Unit of Human Psychopharmacology, Medical College of St. Bartholomew's Hospital, London, UK.
Goodall
E
E
Silverstone
T
T
D000328:Adult; D003913:Dextroamphetamine / Q000494:pharmacology*; D004311:Double-Blind Method; D004357:Drug Synergism; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D008297:Male; D012016:Reference Values; D013237:Stereoisomerism
D005277:Fenfluramine; D003913:Dextroamphetamine; D006854:Hydrocortisone