Regeneration of adult budgerigar's hair cells following acoustic trauma.
The functional and structural changes of hair cells of the adult budgerigar following acoustic trauma were examined using auditory brainstem response (ABR), and both scanning and transmission electron microscopy. Just after exposure to a 1,500-Hz pure tone at 120 dBSPL for 98 h, severe damages and disappearance of short hair cells were observed in the middle region of the basilar papilla. Fourteen days after the exposure, the threshold of ABR recovered to the level before the exposure, and normal short hair cells, which have synapses with nerve endings, were rearranged all over the damaged region of the basilar papilla. These results indicate that the hair cells of the adult budgerigar have capability to regenerate, and to restore the auditory perceptive function following acoustic trauma.
Umemoto
M
M
Department of Otolaryngology, Osaka University Medical School, Japan.
Sakagami
M
M
Ashida
K
K
Fukazawa
K
K
Matsunaga
T
T
Senda
T
T
D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem; D006198:Hair Cells, Auditory / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D006317:Hearing Loss, Noise-Induced / Q000473:pathology*; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D009416:Nerve Regeneration; D011563:Psittaciformes