title: Changes in left ventricular performance after global ischemia: assessing LV pressure-volume relationship.
abstract: To determine the effect of ischemia and reperfusion on left ventricular systolic function, we studied the ischemia-induced rightward shift of the ventricular pressure-volume relationship. Eight mongrel dogs were intubated, and their hearts were exposed through a thoracotomy. A conductance catheter and micromanometer were used to obtain instantaneous left ventricular pressure-volume data. The dogs were subjected to 20 minutes of normothermic global myocardial ischemia, followed by 80 minutes of reperfusion under total cardiopulmonary bypass. Data were acquired during transient (10- to 12-second) periods of acute volume loading before ischemia and at 20-minute intervals during reperfusion as bypass was continued. The relationship between stroke work and end-diastolic volume (ie, preload recruitable stroke work [PRSW]) and the end-systolic pressure-volume relationship were highly linear throughout the study (mean r = 0.954 to 0.983 for PRSW; mean r = 0.954 to 0.984 for end-systolic pressure-volume relationship). Ischemia produced changes in the PRSW: (1) the slope decreased significantly at 20 minutes and 40 minutes of reperfusion then returned to preischemic levels at 60 minutes and 80 minutes, and (2) the x-intercept increased significantly up to 60 minutes. The preload recruitable work area (the area under the linear regression line of PRSW) reflected changes in both slope and x-intercept of PRSW and was significantly decreased throughout the 80 minutes of reperfusion despite gradual recovery. The slope and the x-intercept of the end-systolic pressure-volume relationship did not change after ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: First Department of Surgery, Osaka University Medical School, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Matsuwaka
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: R
authors.initials: R
authors.lastname: Shirakura
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: N
authors.initials: N
authors.lastname: Fukushima
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: S
authors.initials: S
authors.lastname: Nakano
authors.forename: Y
authors.initials: Y
authors.lastname: Kawashima
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002315:Cardiopulmonary Bypass; D004285:Dogs; D015424:Reperfusion; D013318:Stroke Volume / Q000502:physiology*; D013599:Systole / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*