Trisomy 4 in a case of acute myelogenous leukemia accompanied by subcutaneous soft tissue tumors. Report of a case and review of the literature.
We report a patient with acute myelogenous leukemia [AML, French-American-British classification (FAB) M2] with trisomy 4, who developed subcutaneous soft tissue tumors at the time leukemia was diagnosed. A review of the literature on AML with trisomy 4 suggests a relation between trisomy 4 and tumor formation of leukemic cells.
Suenaga
M
M
Department of Internal Medicine, Kumamoto National Hospital, Japan.
Sanada
I
I
Tsukamoto
A
A
Sato
M
M
Kawano
F
F
Shido
T
T
Miura
K
K
Tominaga
R
R
D000368:Aged; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D017254:Leukemic Infiltration / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014314:Trisomy