Lack of effect of acetaldehyde on the cardiovascular system in rats.
The present study was designed to evaluate the kinetics of acetaldehyde (ACT) and and its action on the cardiovascular system in rats. ACT (3, 6, 12 mg/kg i.p.) causes accumulation of this metabolite in the blood, at a concentration corresponding to that obtained from ethanol metabolism after its administration in doses of 1, 2, 4 g/kg p.o., respectively. After intraperitoneal injection of ACT there were no significant changes in blood pressure and heart rate in comparison to the control group. It appears that, in rats, ACT has no influence on the function of the cardiovascular system after the ingestion of ethanol.
Pawlak
D
D
Department of Pharmacodynamics, Medical Academy, Bialystok, Poland.
Morelowska-Spierzak
D
D
Azzadin
A
A
Wróbel
K
K
Buczko
W
W
D000079:Acetaldehyde / Q000493:pharmacokinetics / Q000633:toxicity*; D000428:Alcohol Drinking / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics / Q000633:toxicity; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000431:Ethanol; D000079:Acetaldehyde