title: [Effects of exercise on immune functions in mice].
abstract: This study was carried out to examine the effects of forced running exercise on the immune functions of male ICR mice. Mice aged 4 weeks were divided into two groups: a non-exercise group (control) and a group given forced running exercise (exercise group). The exercise applied was forced running at 15m/min on a flat floor without any slope for 60 min a day. The duration of exercise was 5 days per week for 12 weeks. The results obtained were as follows: 1) After 12 weeks of forced running exercise, the weight of the anterior tibialis muscle and succinate dehydrogenase activity in the anterior tibialis muscle increased significantly (p < 0.01) in the exercise group compared with the control group. A tendency for thymus weight to increase was shown in the exercise group, and liver and spleen weights were significantly (p < 0.01) greater than in the control group. 2) The potentiation of phagocytic function of the reticulo-endothelial system, examined by the carbon clearance method, was seen in the exercise group. 3) The ability of peritoneal macrophages (M phi) to phagocytose latex beads significantly increased (p < 0.01) in the exercise group. The acid phosphatase activity of peritoneal M phi remained in both groups. However, lactate dehydrogenase activity of peritoneal M phi significantly increased (p < 0.01) in the exercise group compared with the control group. 4) The proliferation of splenocytes induced by Con A in the exercise group significantly increased (p < 0.01) compared with the control group.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Health and Physical Education, Gifu Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sugiura
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: K
authors.initials: K
authors.lastname: Washino
authors.forename: R
authors.initials: R
authors.lastname: Inaba
authors.forename: H
authors.initials: H
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Maeno
mesh_terms: D000818:Animals; D008213:Lymphocyte Activation; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012157:Mononuclear Phagocyte System / Q000276:immunology; D009132:Muscles / Q000201:enzymology; D010587:Phagocytosis; D005082:Physical Exertion / Q000502:physiology*; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D013385:Succinate Dehydrogenase