title: Insulin-dependent diabetes mellitus associated with Graves' disease and idiopathic hypoparathyroidism.
abstract: We report a case of 26-year-old woman with Graves' disease and idiopathic hypoparathyroidism diagnosed at 11 years of age, who subsequently developed insulin-dependent diabetes mellitus (IDDM) at 17 years of age. Treatment with antithyroid agents had failed to control her Graves' disease and her IDDM was unmanageable despite insulin therapy. Surgical intervention was carried out, resulting in an improvement of both her hyperthyroidism and IDDM. This case is the first report of polyglandular autoimmune (PGA) syndrome, presenting the association of IDDM, Graves' disease and idiopathic hypoparathyroidism.
authors.affiliation: First Department of Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: A
authors.initials: A
authors.lastname: Ohsawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Yokoh
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000601:surgery / Q000628:therapy; D016883:Diabetic Ketoacidosis / Q000628:therapy; D005260:Female; D006029:Glycosuria / Q000378:metabolism; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007011:Hypoparathyroidism / Q000150:complications* / Q000601:surgery / Q000628:therapy; D007328:Insulin / Q000627:therapeutic use; D011441:Propylthiouracil / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D007328:Insulin; D013963:Thyroid Hormones; D011441:Propylthiouracil