The role of the contractile fibroblast in the capsules around tissue expanders and implants.
The occurrence, structure and contractility of myofibroblasts in the capsules around tissue expanders and static implants has been studied in the rat, pig and humans. The capsules showed a characteristic layered structure with myofibroblasts being the predominant cell type. Capsular strips contract in vitro in a manner characteristic of fibroblast contraction. The contractile ability decreased with the time since expander insertion; and increased with expander exposure, peri-expander infection and clinical evidence of adverse capsular contracture. An hypothesis is proposed that capsular contracture is analogous to wound contraction, and that intraimplant pressure usually inhibits capsular contraction. Evidence is shown from intraexpander pressure measurements to support this hypothesis. The clinical implications for tissue expansion and breast augmentation are discussed.
Coleman
D J
DJ
Plastic Surgery and Burns Research Unit, University of Bradford, UK.
Sharpe
D T
DT
Naylor
I L
IL
Chander
C L
CL
Cross
S E
SE
D000818:Animals; D005260:Female; D005347:Fibroblasts / Q000502:physiology* / Q000648:ultrastructure; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D016462:Mammaplasty; D011183:Postoperative Complications / Q000503:physiopathology; D019736:Prostheses and Implants / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013552:Swine; D013997:Time Factors; D015625:Tissue Expansion Devices / Q000009:adverse effects*