title: Cytomegalovirus antigenemia: clinical correlations in transplant recipients and in persons with AIDS.
abstract: We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.
authors.affiliation: Infectious Disease Unit, Massachusetts General Hospital, Boston.
authors.forename: T
authors.initials: T
authors.lastname: Mazzulli
authors.forename: R H
authors.initials: RH
authors.lastname: Rubin
authors.forename: M J
authors.initials: MJ
authors.lastname: Ferraro
authors.forename: R T
authors.initials: RT
authors.lastname: D'Aquila
authors.forename: S A
authors.initials: SA
authors.lastname: Doveikis
authors.forename: B R
authors.initials: BR
authors.lastname: Smith
authors.forename: T H
authors.initials: TH
authors.lastname: The
authors.forename: M S
authors.initials: MS
authors.lastname: Hirsch
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000956:Antigens, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000382:microbiology*; D006801:Humans; D009504:Neutrophils / Q000382:microbiology; D016377:Organ Transplantation / Q000009:adverse effects*
chemical_list: D000956:Antigens, Viral