Complexes of Cu(II) with Asn-Ser-Phe-Arg-Tyr-NH2; an example of metal ion-promoted conformational organization which results in exceptionally high complex stability.
The pentapeptide fragment of ANF, Asn-Ser-Phe-Arg-Tyr-NH2, coordinates to Cu(II) using the same four nitrogen donor centers as simple pentapeptides such as pentaalanine yet the complexes are of much higher stability as a result of a highly organized side-chain structure which is present in the complex but absent from the free ligand.
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Institute of Chemistry, University of Wroclaw, Poland.
Kozlowski
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Kupryszewski
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Mackiewicz
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Pettit
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Robbins
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R
D000595:Amino Acid Sequence; D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D003300:Copper; D004355:Drug Stability; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry*; D011199:Potentiometry; D011485:Protein Binding; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D009842:Oligopeptides; D010446:Peptide Fragments; C084743:asparaginyl-seryl-phenylalanyl-arginyl-tyrosinamide; D003300:Copper; D009320:Atrial Natriuretic Factor