Beat the clock: paradigms for NTPases in the maintenance of biological fidelity.
Kinetic proofreading is a strategy used by cells to reduce the number of errors made when replicating and expressing genetic information. Recent advances in mRNA splicing suggest a variation on the theme of previously described kinetic proofreading mechanisms, which may apply to other multicomponent assembly processes in the cell.
Burgess
S M
SM
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
Guthrie
C
C
D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D004261:DNA Replication; D043583:Nucleoside-Triphosphatase; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012441:Saccharomyces cerevisiae
D012333:RNA, Messenger; D017766:Acid Anhydride Hydrolases; D043583:Nucleoside-Triphosphatase