title: Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia: a study of two unrelated Italian cases.
abstract: MSLT and immunogenetic findings in two unrelated Italian subjects with recurrent monosymptomatic hypersomnia are reported. In both patients MSLT documented a markedly increased daytime sleep propensity during the attacks without augmented REM sleep pressure. Both patients share the same HLA haplotype (HLA-DR1, DQ1) which has been found in Kleine-Levin syndrome. This makes these subtypes of recurrent hypersomnia indistinguishable one from the other, under the immunogenetic profile, but permits differentiation from narcolepsy which is HLA-DR2, DQ1 closely linked.
authors.affiliation: Institute of Neurology C. Mondino, University of Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Manni
authors.forename: M
authors.initials: M
authors.lastname: Martinetti
authors.forename: M T
authors.initials: MT
authors.lastname: Ratti
authors.forename: A
authors.initials: A
authors.lastname: Tartara
mesh_terms: D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D006683:HLA-DQ Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007558:Italy; D017593:Kleine-Levin Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D008297:Male; D009290:Narcolepsy / Q000175:diagnosis / Q000235:genetics; D010641:Phenotype; D017286:Polysomnography; D012008:Recurrence; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens