title: Temporal modulation transfer function of vision by pattern visual evoked potentials in patients with optic neuritis.
abstract: To reveal the impairment of the temporal modulation transfer function of vision in patients with optic neuritis, the pattern visual evoked potentials (P-VEPs) were recorded at reversal frequencies ranging from 4 to 24 per second, and the fast Fourier transform (FFT) of VEPs were investigated. In normal subjects, curves of the square root of the power of the FFTs of P-VEPs versus temporal frequency showed the maximum peak at 6 Hz (12 reversals/s). The specific distribution of the power spectrum could be found at each temporal frequency, and the amplitudes of higher harmonic components decreased while a single power spectrum peak became prominent as the temporal frequency increased. In patients with optic neuritis, an abnormality of the power spectrum of steady-state P-VEPs could by detected by estimating the 1st and 2nd harmonic components. The abnormality of the power spectrum of transient P-VEPs could be detected by estimating the higher harmonic components of the power spectrum.
authors.affiliation: Department of Ophthalmology, Niigata University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Yoshizawa
authors.forename: T
authors.initials: T
authors.lastname: Usui
mesh_terms: D000328:Adult; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005583:Fourier Analysis; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology; D009902:Optic Neuritis / Q000503:physiopathology*; D010364:Pattern Recognition, Visual; D011601:Psychophysics; D014785:Vision, Ocular / Q000502:physiology*; D014792:Visual Acuity