[The growth stimulation of a cell culture of dissociated rat embryonic spinal cord under the influence of the opioid peptide dalargin and the opioid receptor blocker naloxone].
Effect of synthetic analog of [Leu]-enkephalin dalargin and naloxone as a opioid blocker on fetal rat spinal cord cells was studied. It was found that the aggregation place during dalargin action had increased on average by 1.85 compared to the control, during naloxone action had increased on average by 1.78 compared to the control. The fact that brain cells reactions on opioid and on naloxone are the same and naloxone-peptide mixture is more active by 2.5 times compared to control suggests that these agents effect the cells with the help of receptors of different types, thus these agents are growth factors for nervous tissue, they increase survival and adhesion of the cells of CNS.
Kalenchuk
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D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D004622:Embryo, Mammalian; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects*; D013268:Stimulation, Chemical
D009414:Nerve Growth Factors; D009270:Naloxone; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Stimuliatsiia rosta kul'tury kletok dissotsiirovannogo spinnogo mozga émbrionov krys pod vliianiem opioidnogo peptida dalargina i blokatora opioidnykh retseptorov naloksona.