Adhesion molecules and cytokine production.
The exchange of cross-talks between cells relies on soluble factors or direct cell-cell contact. Soluble factors increase the expression of cell surface molecules that activate adjacent cells by direct contact to produce cytokines. In the lung, dendritic cells are potent inducers of T-cell proliferation, and the interaction between the two leads to the production of high amounts of TNF alpha and TNF beta. Of the molecules involved in these biologic functions, LFA-3, CD11c, and the combination of beta 1 and beta 2 integrins are the most efficient. However, blocking TNF alpha or TNF beta production does not affect the alloreaction. The interaction between activated T cells and monocytes resulted in a large production of IL-1 beta. In this reaction, CD69, CD2, and the beta 2 integrins (CD11a, b, c, and CD18) and also other molecules such as a 25- to 35-kD glycoprotein play an important part. Finally, interaction between monocytes and fibroblasts leads to the production of large amounts of collagenase and PGE2 by fibroblasts. Cell-associated IL-1, particularly IL-1 alpha and membrane-bound TNF alpha, can also play a crucial role in the process of cell-cell interaction. This interaction may be controlled by inhibitors to IL-1 and TNF.
Dayer
J M
JM
Department of Medicine, University Hospital, Geneva, Switzerland.
Isler
P
P
Nicod
L P
LP
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D003713:Dendritic Cells / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D008168:Lung / Q000166:cytology; D009000:Monocytes / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D015815:Cell Adhesion Molecules; D016207:Cytokines