title: Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties.
abstract: A new inhibitor of mammalian adenosine triphosphatases, designated aquastatin A, has been isolated from a fungus identified as Fusarium aquaeductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na+/K(+)-ATPase with an IC50 value of 7.1 microM, and H+/K(+)-ATPase with an apparent IC50 value of 6.2 microM.
authors.affiliation: Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hamano
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita-Okami
authors.forename: K
authors.initials: K
authors.lastname: Minagawa
authors.forename: H
authors.initials: H
authors.lastname: Haruyama
authors.forename: T
authors.initials: T
authors.lastname: Kinoshita
authors.forename: T
authors.initials: T
authors.lastname: Hosoya
authors.forename: K
authors.initials: K
authors.lastname: Furuya
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Tabata
authors.forename: A
authors.initials: A
authors.lastname: Hemmi
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004285:Dogs; D005285:Fermentation; D005670:Fusarium / Q000737:chemistry*; D005697:Galactosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012459:Salicylates; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013552:Swine
chemical_list: D001565:Benzoates; D005697:Galactosides; D012459:Salicylates; C085031:aquastatin A; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase