title: Effect of epinephrine on local partial pressure of oxygen in the ciliary processes.
abstract: Local pO2 was measured close to the ciliary process of the rabbit eye using polarographic microelectrodes under microendoscopic observation. The experiments were performed in 5 anaesthetized New Zealand rabbits. Changes in local pO2, intraocular pressure (IOP) and blood flow velocity (BFV) were investigated after intra-arterial and topical application of epinephrine. After intra-arterial epinephrine, a simultaneous decrease in BFV, IOP and local pO2 was found. pO2 decrease was more pronounced in the anterior part of the ciliary processes than in the posterior part. Topical epinephrine lead to similar changes of all parameters mentioned above, the time constants being 10-20 times longer. In these topical experiments, no recovery of local pO2 was found over a period of at least 30 min despite an increase in BFV. Our results indicate that in the hyperemic phase after epinephrine the activity of the ciliary epithelium (and probably the total aqueous formation) is higher than normal. Thus, the decrease in IOP in this phase must be due to an increased outflow facility.
authors.affiliation: Institut für Physiologie und Kardiologie, Universität Erlangen-Nürnberg, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Höper
authors.forename: R H
authors.initials: RH
authors.lastname: Funk
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002924:Ciliary Body / Q000098:blood supply / Q000187:drug effects*; D004724:Endoscopy; D004837:Epinephrine / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects; D008839:Microelectrodes; D010100:Oxygen / Q000502:physiology*; D010313:Partial Pressure; D010781:Photography; D011048:Polarography; D011817:Rabbits
chemical_list: D010100:Oxygen; D004837:Epinephrine