title: Combined local excision and brachytherapy with ruthenium-106 in the treatment of epibulbar malignancies.
abstract: Two patients with epibulbar malignancies were treated by local excision and brachytherapy with ruthenium-106. One patient showed a large melanoma on the epibulbar conjunctiva, the other patient suffered from a recurrent squamous cell carcinoma at the limbus. After excision of the tumor including lamellar sclerectomy and keratectomy, a ruthenium-106 plaque was sutured to the sclera, and a total dose of 290 and 320 Gy, respectively, was delivered to the tumor bed. No severe radiogenic complications were observed except for a rarefaction of the sclera in the treatment area and a slow cataract increase. After a follow-up period of 50 and 22 months, respectively, both patients do not show any recurrence or metastatic disease.
authors.affiliation: First Department of Ophthalmology, University of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Zehetmayer
authors.forename: R
authors.initials: R
authors.lastname: Menapace
authors.forename: W
authors.initials: W
authors.lastname: Kulnig
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D003230:Conjunctival Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D003316:Corneal Diseases / Q000532:radiotherapy / Q000601:surgery; D005128:Eye Diseases / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy* / Q000601:surgery*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*
chemical_list: D012429:Ruthenium Radioisotopes