Anticoagulant and estrogenic effects of two new 17 beta-aminoestrogens, butolame [17 beta-(4-hydroxy-1-butylamino)-1,3,5(10)-estratrien-3-ol] and pentolame [17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol].
The syntheses and characterizations of two new 17 beta-aminoestrogens, butolame [17 beta-(4-hydroxy-1-butylamino)-1,3,5(10)-estratrien-3-ol] and pentolame [17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol], are presented. Both compounds, when administered in single subcutaneous injections to male mice and rats, produce dose-dependent increases in blood clotting times that may last several days. The estrogenic effects assessed by the vaginal cornification test are of relatively short duration.
Lemini
C
C
Departmento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México.
Rubio-Póo
C
C
Silva
G
G
García-Mondragón
J
J
Zavala
E
E
Mendoza-Patiño
N
N
Castro
D
D
Cruz-Almanza
R
R
Mandoki
J J
JJ
D000605:Amino Alcohols / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D045166:Estradiol Congeners / Q000138:chemical synthesis* / Q000494:pharmacology; D004963:Estrenes / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D007700:Kinetics; D008297:Male; D051379:Mice; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D014621:Vagina / Q000187:drug effects / Q000502:physiology
D000605:Amino Alcohols; D000925:Anticoagulants; D045166:Estradiol Congeners; D004963:Estrenes; C083219:butolame; C083220:pentolame