[Translocation and multiple organ failure].
A review of bacterial translocation and multiple organ failure (MOF) is presented. Splanchnic ischaemia plays a central role in the development of MOF, but the exact mechanism of translocation is unclear. The concentration of endotoxins and bacteria in the gut is high. The critically ill patient is often treated with antibiotics with a broad antibacterial spectrum and overgrowth of Gram negative bacteria will take place in the gut favouring the translocation phenomenon. The regime of selective gut decontamination is discussed. Regional and systemic oxygen kinetics together with metabolic markers are important in detecting splanchnic ischaemia. Hepatic vein catheterisation and gastric mucosa pHi are discussed. The regional inflammation in the gut is often initiated by endotoxins, which stimulate the cytokines IL-1, IL-6 and TNF. Another important factor that can accentuate inflammation of the gut is reperfusion injury. A proposal for treatment of splanchnic ischaemia and translocation is discussed i.e.: optimizing central haemodynamic parameters, optimizing the regional microcirculation, treatment with antibodies to endotoxins, gut decontamination and early enteral nutrition. When splanchnic hypoperfusion is detected it cannot be ignored. It may be possible to correct the hypoperfusion with early gastrointestinal resuscitation and to thereby reduce the duration and mortality of MOF. The above mentioned suggestions are all very demanding of resources, but have to be considered in gut directed therapy.
Jensen
T H
TH
Rigshospitalet, anaestesi- og intensiv afdeling, København.
Heslet
L
L
Fomsgaard
A
A
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001419:Bacteria / Q000302:isolation & purification; D001422:Bacterial Adhesion; D018407:Bacterial Physiological Phenomena; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D007511:Ischemia / Q000209:etiology; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology; D013152:Splanchnic Circulation
D000900:Anti-Bacterial Agents
Translokation og multiorgansvigt.