title: The toxicity of seed extracts and their fractions from Lupinus angustifolius L. and Lupinus albus L.
abstract: Seed extracts obtained from Lupinus albus and Lupinus angustifolius by treatment with 48% ethanol contained ca. 10% alkaloids (on a dry weight basis) and were non-toxic. Their acute toxicity (LD50) in the mouse is > 4000 mg kg-1 body wt. After fractionation, the extract from L. angustifolius seeds afforded several fractions with differing toxicities (LD50 750-4000 mg kg-1 body wt.). None of the fractions tested in vitro were toxic. The results obtained showed that, in spite of the alkaloids, other low-molecular-weight constituents present significantly modified the toxicity of the lupin extracts.
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań.
authors.forename: M
authors.initials: M
authors.lastname: Stobiecki
authors.forename: B
authors.initials: B
authors.lastname: Blaszczyk
authors.forename: S H
authors.initials: SH
authors.lastname: Kowalczyk-Bronisz
authors.forename: K
authors.initials: K
authors.lastname: Gulewicz
mesh_terms: D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000633:toxicity*; D012639:Seeds / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D010936:Plant Extracts