Effect of polybutadiene on the encapsulation efficiency of ethyl cellulose microcapsules of sulphadiazine.
The coacervation-inducing effect of polybutadiene (PBD), a liquid telomer of butadiene, in microencapsulation of sulphadiazine was investigated, using phase separation coacervation of ethyl cellulose, by solvent alteration, in heavy mineral oil medium. The effects of protective colloids and core-wall ratio on encapsulation efficiency were studied. Efficacy of PBD was studied compared to polyisobutylene (PIB). Experimental results revealed that PBD ensured better encapsulation efficiency compared to PIB.
Das
S K
SK
School of Pharmacy, Memorial University of Newfoundland, St John's, Canada.
D002070:Butadienes / Q000737:chemistry*; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004339:Drug Compounding; D020724:Elastomers; D008855:Microscopy, Electron, Scanning; D008899:Mineral Oil; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012997:Solvents; D013411:Sulfadiazine / Q000008:administration & dosage / Q000737:chemistry*
D002070:Butadienes; D002214:Capsules; D020724:Elastomers; D011108:Polymers; D012997:Solvents; D013411:Sulfadiazine; C013517:ethyl cellulose; D008899:Mineral Oil; C028834:polybutadiene; D002482:Cellulose