[Phosphorylation of cytochrome P-450SCC by protein kinase C. The protective effect of adrenodoxin and cytochrome b5].
Cytochrome P-450scc from bovine adrenal cortex mitochondria was shown to be selectively phosphorylated by protein kinase C. The amino acid residues most accessible to phosphorylation by protein kinase C are located in the N-terminal sequence of cytochrome P-450scc. Adrenodoxin and cytochrome b5 protect cytochrome P-450scc from phosphorylation, this effect being dependent on the protein concentration.
Lobanov
N A
NA
Institute of Biochemistry and Molecular Biology, University of Bern, Switzerland.
Khenseĭ
K
K
Usanov
S A
SA
Atstsi
A
A
D000311:Adrenal Glands / Q000201:enzymology; D000325:Adrenodoxin / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000737:chemistry / Q000378:metabolism*; D015786:Cytochromes b5 / Q000494:pharmacology*; D008861:Microsomes / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011817:Rabbits
D000325:Adrenodoxin; D015786:Cytochromes b5; D002786:Cholesterol Side-Chain Cleavage Enzyme; D011493:Protein Kinase C
Fosforilirovanie tsitokhroma P-450SCC proteinkinazoĭ C. Zashchitnyĭ éffekt adrenodoksina i tsitokhorma b5.