title: Modulation by divalent cations of the current generated by vasopressin in facial motoneurons.
abstract: Vasopressin generates a voltage-gated, sodium-dependent current in facial motoneurons in brainstem slices. Reducing the extracellular calcium concentration from 2 to 0.01 mM caused a 30 to 120% increase in the amplitude of this current. Lowering extracellular magnesium also enhanced it, but less efficiently. In the physiological solution, the response of facial neurons to vasopressin is thus partially blocked. Increasing extracellular calcium was without effect. Current-voltage curves indicate that the vasopressin current reversed at around 0 mV and suggest that the low-calcium-induced potentiation was due to an attenuation of the region of negative slope conductance.
authors.affiliation: Department of Physiology, University Medical Center, Geneva, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Alberi
authors.forename: M
authors.initials: M
authors.lastname: Dubois-Dauphin
authors.forename: J J
authors.initials: JJ
authors.lastname: Dreifuss
authors.forename: M
authors.initials: M
authors.lastname: Raggenbass
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002413:Cations, Divalent / Q000378:metabolism*; D004553:Electric Conductivity; D005110:Extracellular Space / Q000378:metabolism; D005154:Facial Nerve / Q000502:physiology*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009046:Motor Neurons / Q000187:drug effects* / Q000502:physiology*; D009994:Osmolar Concentration; D051381:Rats; D017207:Rats, Sprague-Dawley; D014667:Vasopressins / Q000502:physiology*
chemical_list: D002413:Cations, Divalent; D014667:Vasopressins; D008274:Magnesium; D002118:Calcium