title: Effects of giving water 20-450 ml with oral diazepam premedication 1-2 h before operation.
abstract: We have studied the volume of water which should accompany diazepam 10 mg oral premedication given 1-2 h before induction of anaesthesia in 75 patients undergoing elective gynaecological laparoscopy. Twenty-five patients were given 20 ml (group A), 25 patients 150 ml (group B), and 25 patients 300-450 ml of water (group C). There were no differences between the groups in gastric fluid volume and acidity. All groups reported a reduction in thirst and dryness of the mouth after water intake, while only group B reported significant anxiolysis. Eight patients in group C experienced augmented diuresis, compared with no patients in groups A and B. We conclude that 150 ml is the ideal amount of water given with oral premedication 1-2 h before anaesthesia.
authors.affiliation: Department of Anaesthesia, Rogaland Central Hospital, Stavanger, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Søreide
authors.forename: H
authors.initials: H
authors.lastname: Holst-Larsen
authors.forename: K
authors.initials: K
authors.lastname: Reite
authors.forename: H
authors.initials: H
authors.lastname: Mikkelsen
authors.forename: J A
authors.initials: JA
authors.lastname: Søreide
authors.forename: P A
authors.initials: PA
authors.lastname: Steen
mesh_terms: D000328:Adult; D003975:Diazepam / Q000008:administration & dosage*; D004326:Drinking; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D011229:Preanesthetic Medication; D013894:Thirst; D013997:Time Factors
chemical_list: D003975:Diazepam