title: Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.
abstract: Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most reports have been in adult patients, with rare reports in the pediatric population. We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21. As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is "at risk" for suppression, and, thus warrant close evaluation while on such medications.
authors.affiliation: Department of Pediatrics, Pennsylvania State University Children's Hospital, Hershey 17033.
authors.forename: M M
authors.initials: MM
authors.lastname: Gleason
authors.forename: J S
authors.initials: JS
authors.lastname: Roloff
authors.forename: S E
authors.initials: SE
authors.lastname: Cyran
authors.forename: H S
authors.initials: HS
authors.lastname: Weber
authors.forename: B G
authors.initials: BG
authors.lastname: Baylen
authors.forename: J L
authors.initials: JL
authors.lastname: Myers
mesh_terms: D001853:Bone Marrow / Q000187:drug effects*; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006330:Heart Defects, Congenital / Q000235:genetics* / Q000601:surgery; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*; D011182:Postoperative Care
chemical_list: D002216:Captopril