Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation.
A standard jet nebuliser was used to generate a radiolabelled aerosol and the pattern of deposition within the airways of eight healthy adults was studied with a gamma camera. Penetration of aerosol to the lung was greatly reduced when breathing through the nose compared with mouth breathing.
Everard
M L
ML
Department of Child Health, Queens Medical Centre, Nottingham.
Hardy
J G
JG
Milner
A D
AD
D000280:Administration, Inhalation; D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D016284:Technetium Tc 99m Pentetate
D000336:Aerosols; D016284:Technetium Tc 99m Pentetate