Impact of omeprazole on the plasma clearance of methotrexate.
Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.
Reid
T
T
Department of Medicine, Stanford University Medical Center, CA 94305.
Yuen
A
A
Catolico
M
M
Carlson
R W
RW
D000328:Adult; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy; D000075202:Contraindications; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008727:Methotrexate / Q000097:blood / Q000493:pharmacokinetics*; D009853:Omeprazole; D012516:Osteosarcoma / Q000097:blood / Q000188:drug therapy
D009853:Omeprazole; D008727:Methotrexate