title: Measurement of CI-979 (a candidate drug for the treatment of age-related disorders of cognition) in human plasma by capillary gas chromatography with nitrogen-selective detection.
abstract: A specific and highly sensitive method for the measurement of CI-979 in human plasma is described. The compound and internal standard were extracted from alkalinized plasma with methyl tert.-butyl ether and analyzed by capillary gas chromatography with nitrogen-selective detection. The method was demonstrated to be accurate and precise. Since the limit of quantitation was 0.10 ng/ml, this method was suitable for clinical pharmacokinetic studies in which subjects received repeated administration of 0.5-2.5 mg CI-979 every 6 h.
authors.affiliation: Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105.
authors.forename: B L
authors.initials: BL
authors.lastname: Windsor
authors.forename: L L
authors.initials: LL
authors.lastname: Radulovic
authors.forename: H N
authors.initials: HN
authors.lastname: Bockbrader
authors.forename: T
authors.initials: T
authors.lastname: Chang
mesh_terms: D002849:Chromatography, Gas; D004095:Dihydropyridines / Q000097:blood*; D006801:Humans; D007202:Indicators and Reagents; D010091:Oximes / Q000097:blood*; D011619:Psychotropic Drugs / Q000097:blood*; D012015:Reference Standards; D012997:Solvents
chemical_list: D004095:Dihydropyridines; D007202:Indicators and Reagents; D010091:Oximes; D011619:Psychotropic Drugs; D012997:Solvents; C084978:milameline