title: The use of sumatriptan in the treatment of migraine.
abstract: Sumatriptan is a selective agonist of 5-hydroxytryptamine receptors, recommended for the acute treatment of migraine. The 5-HT1 receptor subtype is found in the cranial vasculature of many species including humans, and causes vasoconstriction of these vessels. Sumatriptan as a highly potent 5-HT1 agonist selectively constricts large intracranial blood vessels and also blocks neurogenic inflammation. Those treating patients with severe or inconveniently timed attacks will find sumatriptan the drug of choice.
authors.affiliation: Royal and East Surrey Neurology Research Unit, Royal Surrey County Hospital, Guildford.
authors.forename: M
authors.initials: M
authors.lastname: Gross
mesh_terms: D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D018170:Sumatriptan / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D012702:Serotonin Antagonists; D018170:Sumatriptan