[Determination of albendazole and its main metabolite albendazole sulfoxide in the hydatid fluid of human echinococcal cysts using HPLC].
Concentrations of albendazole and its active metabolite in echinococcal cyst of the human liver were determined in order to evaluate drug effects of the decrease of protoscolex vitality. Albendazole concentration of 0-64.9 micrograms/ml and albendazole sulfoxide of 0-40.8 micrograms/ml were found in cysts. The protoscolexes showed markedly manifested morphologic changes up to the disintegration. The postoperative follow up of patients within 24 months discovered no recidives of the disease and the patients were regarded as cured. On the basis of the results obtained it has been concluded that the use of albendazole in the dose of 800 mg/day within 28 day is sufficient for achievement of therapeutic drug level in vivo conditions.
Glisović
L
L
Vojnomedicinska akademija, Odeljenje za toksikolosku hemiju, Klinika za gastroenterologiju.
Kilibarda
V
V
Redzić
B
B
Stanković
N
N
Radulović
S
S
D000328:Adult; D015766:Albendazole / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D000871:Anthelmintics / Q000493:pharmacokinetics; D002648:Child; D002851:Chromatography, High Pressure Liquid; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000871:Anthelmintics; D015766:Albendazole; C027186:albendazole sulfoxide
Odredivanje albendazola i glavnog metabolita albendazol sulfoksida u hidatidnoj tecnosti ehinokoknih cista ljudi metodom HPLC.