[Prophylactic and therapeutic effect of jiawei zhigancao tang injection on experimental arrhythmia in rats].
The antiarrhythmic effect of Jiawei Zhigancao Tang injection (JZTI) was studied in experimental arrhythmia induced by aconitine or by CaCl2 in anesthetized rats. The prophylactic dose of JZTI (5g/kg, i.v.) reduced the incidence rate of premature ventricular complexes, ventricular tachycardia (P < 0.01), delayed the onset time of arrhythmia induced by CaCl2 (P < 0.01), and the recovery time of sinus rhythm occurred earlier than that of control group (P < 0.01). The therapeutic dose of JZTI (10g/kg, i.v.) raised the rate of aconitine-induced arrhythmia to sinus rhythm conversion (P < 0.05). The results showed that JZTI could significantly antagonize arrhythmia induced by aconitine or by Cacl2 in rats.
Cui
Z Q
ZQ
Dept. of Pharmacology, Tianjin Medical College.
Zhang
H R
HR
Lin
X Z
XZ
D000157:Aconitine; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D002122:Calcium Chloride; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051381:Rats; D017180:Tachycardia, Ventricular / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control
D004365:Drugs, Chinese Herbal; D002122:Calcium Chloride; D000157:Aconitine