Pantherinine, a cytotoxic aromatic alkaloid, and 7-deazainosine from the ascidian Aplidium pantherinum.
A new cytotoxic aromatic alkaloid, pantherinine [1], and a mixture of nucleosides including 7-deazainosine [3], have been isolated from the ascidian Aplidium pantherinum collected at Stenhouse Bay, South Australia. The structures were determined primarily from 1H- and 13C-nmr data, especially one-bond and multiple-bond proton-carbon correlations. Although 7-deazainosine [3] has been known as a synthetic compound for several decades, this appears to be the first report of its isolation as a natural product.
Kim
J
J
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019.
Pordesimo
E O
EO
Toth
S I
SI
Schmitz
F J
FJ
Van Altena
I
I
D000166:Acridines / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology; D013021:South Australia; D014561:Urochordata / Q000737:chemistry*
D000166:Acridines; D000970:Antineoplastic Agents; D015363:Quinolones; C085147:pantherinine