title: Chemical constituents of Aristolochia rigida and mutagenic activity of aristolochic acid IV.
abstract: Two aristolochic acids [2 and 3] and a flavonol glycoside 1 have been isolated from Aristolochia rigida (Aristolochiaceae). Aristolochic acid IV [2], the most abundant constituent, has shown a weak direct mutagenic activity in the Ames test: this action seems to be inhibited, at least in part, by metabolic reactions.
authors.affiliation: Dipartimento di Chimica Bioorganica, Università di Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pistelli
authors.forename: E
authors.initials: E
authors.lastname: Nieri
authors.forename: A R
authors.initials: AR
authors.lastname: Bilia
authors.forename: A
authors.initials: A
authors.lastname: Marsili
authors.forename: R
authors.initials: R
authors.lastname: Scarpato
mesh_terms: D000818:Animals; D034341:Aristolochic Acids; D002855:Chromatography, Thin Layer; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010616:Phenanthrenes / Q000032:analysis / Q000633:toxicity*; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000235:genetics; D012998:Somalia
chemical_list: D034341:Aristolochic Acids; D009153:Mutagens; D010616:Phenanthrenes; D010936:Plant Extracts; C000228:aristolochic acid I