[The mechanism of the development of the synapse as the basis for its involution].
The electron microscopic investigation of human brain synaptic organization in normal aging and in ischemic heart pathology in different life periods was performed. A significant quantity of desmosome-like and mixed contacts was shown. Their ultrastructural organization was similar to that of developing synapses during prenatal ontogenesis and in newborn rats. The analysis of the experimental results suggests that an appearance of desmosome-like contacts in the human brain results from synapse involution. This is supported by the observation of formation of mixed contacts which may be a transitional stage between symmetrical or asymmetrical specialized synapse and desmosome. Thus, the mechanism of synaptic involution appears to be a mirror reflection of the mechanism of its development.
Frumkina
L E
LE
Iakovleva
N I
NI
Bogolepov
N N
NN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D001921:Brain / Q000648:ultrastructure; D003896:Desmosomes / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000473:pathology; D013569:Synapses / Q000648:ultrastructure*
Mekhanizm razvitiia sinapsa kak osnova ego involiutsii.