title: Growth hormone signal transduction.
abstract: Growth hormone (GH) promotes animal growth by stimulating bone and cartilage cell proliferation, and influences carbohydrate and lipid metabolism. Some of these effects are brought about indirectly via somatomedin induction in hepatocytes, others by acting directly on the target cells. In either case, GH first binds to specific receptors on cells to trigger a sequence of biochemical events culminating in a biological response. Recently much has been learnt about the molecular structure of GH receptor, its binding to ligand, and the ensuing signal transduction events.
authors.affiliation: C.N.R. Institute for the Adaptation of Cattle and Buffalo to the Southern Italy Environment (IABBAM), Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Maharajan
authors.forename: V
authors.initials: V
authors.lastname: Maharajan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D013006:Growth Hormone / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D011519:Proto-Oncogenes; D011956:Receptors, Cell Surface / Q000502:physiology; D011986:Receptors, Somatotropin / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D011956:Receptors, Cell Surface; D011986:Receptors, Somatotropin; D013006:Growth Hormone