An experimental method for determining the Hildebrand solubility parameter of organic nonelectrolytes.
A three-solvent system was used to determine the Hildebrand solubility parameters of organic nonelectrolytes. The experimental Hildebrand solubility parameter represents a weighted average of the mole fraction solubilities of the solute in these three individual solvents (ethyl acetate, 1-propanol, and 1,2-propanediol). The solvent system estimated the Hildebrand solubility parameters of solutes within a range from 8.9 to 14.8 (cal/cm3)2(1). Deviations ranged from 0.8 to 12.9%, with the highest value at the extreme and well within 10% at the median. Estimation of the Hildebrand solubility parameters of solutes within a wider range and with somewhat better accuracy was made with a five-solvent system (hexane, ethyl acetate, 1-propanol, 1,2-propanediol, and water).
Lin
H M
HM
College of Pharmacy and Allied Health Professions, St. John's University, Jamacia, NY 11439.
Nash
R A
RA
D008722:Methods; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility
D004364:Pharmaceutical Preparations