[Hodgkin's disease in childhood--northern Israel cancer center experience, 1971-1990].
Records of children treated for Hodgkin's disease between 1971-1990 were analyzed retrospectively, and 102 cases of children younger than 18 years when diagnosed were reviewed. There were 54 boys and 48 girls, with male predominance in those younger than 10 years. 44 patients were of Arab ancestry and 58 were Jewish; the incidence was similar in both groups. Most common were the nodular sclerosing and mixed cellularity types, the latter more common in the younger age group. The outcome of various treatments was evaluated. At diagnosis, 64% were in stages I or II and 34% in stages III or IV. 20 of those in stages I-II received radiotherapy (RT) alone, 10 chemotherapy (CT) alone, and 35 combined CT and RT. Survival rates and median disease-free intervals were statistically similar with all 3 modalities. However, relapse rates were higher with either RT or CT alone (35% and 38%, respectively) than with combined therapy (14%). We conclude that combined CT and RT is superior to RT or CT alone.
Ben-Arush
M
M
Northern Israel Cancer Center, Pathology Dept., Rambam Medical Center, Haifa.
Rosenthal
J
J
Peretz-Nahum
M
M
Kuten
A
A
Ben-Arie
J
J
Ben Shahar
B
B
Yarom
J
J
Robinson
E
E
D000293:Adolescent; D002173:Cancer Care Facilities; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D007557:Israel; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome