title: Determination of penicillamine or tiopronin in pharmaceutical preparations by flow injection analysis.
abstract: Two flow injection analysis (FIA) methods, using spectrophotometric detection, are proposed for the determination of penicillamine or tiopronin [N-(2-mercaptopropionylglycine)]. The procedures are based on the formation of yellow complexes between these thiol-containing drugs and Pd(II), in a 1 M or 0.25 M HCl medium, respectively. With peak height as a quantitative parameter, penicillamine is determined over the range 1.0 x 10(-5)-7.0 x 10(-4) M; for tiopronin the range is 1.0 x 10(-5)-6.0 x 10(-4) M. The methods have been applied to the routine determination of the drugs in pharmaceutical preparations.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
authors.forename: M S
authors.initials: MS
authors.lastname: Garcia
authors.forename: C
authors.initials: C
authors.lastname: Sanchez-Pedreño
authors.forename: M I
authors.initials: MI
authors.lastname: Albero
authors.forename: V
authors.initials: V
authors.lastname: Rodenas
mesh_terms: D002138:Calibration; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D017022:Flow Injection Analysis; D010165:Palladium / Q000737:chemistry; D010396:Penicillamine / Q000032:analysis* / Q000737:chemistry; D008625:Tiopronin / Q000032:analysis* / Q000737:chemistry
chemical_list: D010165:Palladium; D008625:Tiopronin; D010396:Penicillamine