title: Highly polymorphic repeat marker within the beta-amyloid precursor protein gene.
abstract: We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the beta-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivs1, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.
authors.affiliation: Institute of Medical Genetics, A. Gemelli School of Medicine, Catholic University, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Zappata
authors.forename: M B
authors.initials: MB
authors.lastname: Petersen
authors.forename: U
authors.initials: U
authors.lastname: König
authors.forename: J
authors.initials: J
authors.lastname: Blaschak
authors.forename: A
authors.initials: A
authors.lastname: Chakravarti
authors.forename: F
authors.initials: F
authors.lastname: Tassone
authors.forename: A
authors.initials: A
authors.lastname: Serra
authors.forename: S E
authors.initials: SE
authors.lastname: Antonarakis
authors.forename: C
authors.initials: C
authors.lastname: Brahe
mesh_terms: D000483:Alleles; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D001483:Base Sequence; D002891:Chromosomes, Human, Pair 21; D004247:DNA; D017931:DNA Primers / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005819:Genetic Markers; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D016564:Amyloid beta-Protein Precursor; D017931:DNA Primers; D005819:Genetic Markers; D004247:DNA