title: Electrophoretically defined myosin heavy chain patterns of single human muscle spindles.
abstract: At least four myosin heavy chain (MHC) isoforms were separated by SDS-PAGE in extracts of intrafusal fibers isolated by microdissection from human lumbrical muscles. The fastest migrating MHC represents a slow isoform. The slowest migrating MHC was identified as the embryonic MHCemb. A faint band, moving slightly faster than MHCemb, most likely represents a neonatal/fetal MHC isoform. A prominent band, moving between the latter and the slow isoform is suggested to represent a hitherto unidentified, spindle-specific MHC isoform, MHCif.
authors.affiliation: Department of Anatomy, University of Umeå, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Pedrosa-Domellöf
authors.forename: B
authors.initials: B
authors.lastname: Gohlsch
authors.forename: L E
authors.initials: LE
authors.lastname: Thornell
authors.forename: D
authors.initials: D
authors.lastname: Pette
mesh_terms: D000328:Adult; D004591:Electrophoresis, Polyacrylamide Gel; D005333:Fetus / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D009470:Muscle Spindles / Q000737:chemistry* / Q000196:embryology; D009218:Myosins / Q000032:analysis*
chemical_list: D009218:Myosins