Structural repeats in cyclosporin A.
The conformation of various dipeptides of free and cyclophilin A-bound cyclosporin A were compared. Cyclosporin A was shown to contain in both states conformationally duplicated fragments in the putative binding sites for cyclophilin A and phosphatase calcineurin.
Denesyuk
A I
AI
Institute of Immunology, Lyubuchany, Moscow Region, Russia.
Lundell
J
J
Goldman
A
A
Zav'yalov
V P
VP
Korpela
T
T
D000591:Amino Acid Isomerases / Q000378:metabolism; D000595:Amino Acid Sequence; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism; D016572:Cyclosporine / Q000737:chemistry* / Q000378:metabolism; D004151:Dipeptides / Q000737:chemistry; D008958:Models, Molecular; D019696:Peptidylprolyl Isomerase; D011485:Protein Binding; D011487:Protein Conformation
D002352:Carrier Proteins; D004151:Dipeptides; D016572:Cyclosporine; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase