A biochemical marker for differentiation is present in an in vitro aging cell system.
In this study it is shown that in an in vitro aging cell system of human diploid fibroblasts the ratio of the histone variants H2A.1/H2A.2 decreases in a linear manner as a function of cumulative population doublings This ratio is known to decrease during differentiation. This finding reinforces the theory that cellular aging is a result of differentiation and programmed cell death rather than degeneration.
Rogakou
E P
EP
Institute of Biology, N.R.C. Demokritos, Aghia Paraskevi, Attiki, Greece.
Sekeri-Pataryas
K E
KE
D015415:Biomarkers / Q000032:analysis; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D016922:Cellular Senescence; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D014644:Genetic Variation; D006657:Histones / Q000032:analysis* / Q000235:genetics; D006801:Humans
D015415:Biomarkers; D006657:Histones