title: Airway complications after pulmonary transplantation.
abstract: Airway healing was identified initially as one of the fundamental limitations of pulmonary transplantation. Recent experience suggests that this is no longer the case. A series of 67 pulmonary transplants (27 heart-lung, 31 single-lung, 9 double-lung) in 66 patients surviving more than 14 days was reviewed with reference to airway complications. There were 75 anastomoses at risk in two groups as defined by anastomotic location: 47 anastomoses in 38 patients in a bronchial group and 28 anastomoses in 28 patients in a tracheal group. A total of 10 airway complications developed (stenosis in 5 patients [4 bronchial group, 1 tracheal group] and dehiscence in 5 patients [1 bronchial group, 4 tracheal group]) causing two airway-related deaths (2 of 67) in the series. However, no significant correlation could be identified with either ischemic interval, suture technique, type of wrap, preoperative or postoperative steroid therapy, or date of first rejection episode. Airway complications are no longer a major limitation of pulmonary transplantation. Satisfactory airway healing can occur in both the presence of steroid therapy and the absence of an omental or pericardial wrap.
authors.affiliation: Cardio-pulmonary Transplant Unit, Freeman Hospital, Newcastle-upon-Tyne, United Kingdom.
authors.forename: I W
authors.initials: IW
authors.lastname: Colquhoun
authors.forename: A D
authors.initials: AD
authors.lastname: Gascoigne
authors.forename: J
authors.initials: J
authors.lastname: Au
authors.forename: P A
authors.initials: PA
authors.lastname: Corris
authors.forename: C J
authors.initials: CJ
authors.lastname: Hilton
authors.forename: J H
authors.initials: JH
authors.lastname: Dark
mesh_terms: D000293:Adolescent; D000328:Adult; D000402:Airway Obstruction / Q000453:epidemiology* / Q000628:therapy; D000714:Anastomosis, Surgical; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D006084:Graft Rejection / Q000150:complications; D016041:Heart-Lung Transplantation / Q000009:adverse effects; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009852:Omentum / Q000637:transplantation; D011239:Prednisolone / Q000008:administration & dosage; D012189:Retrospective Studies; D013529:Surgical Wound Dehiscence / Q000453:epidemiology*; D013536:Suture Techniques; D013997:Time Factors
chemical_list: D011239:Prednisolone; D008775:Methylprednisolone