title: Cutaneous cryptococcosis in a patient with cutaneous T cell lymphoma receiving therapy with photopheresis and methotrexate.
abstract: Photopheresis is being used with increasing frequency as therapy for patients with neoplastic and dermatologic diseases and is being evaluated as therapy for patients with AIDS. We describe a patient with advanced cutaneous T cell lymphoma who developed pulmonary and cutaneous cryptococcosis after receiving therapy with photopheresis and biweekly methotrexate. We consider the potential roles of cutaneous T cell lymphoma, methotrexate, and photopheresis as predisposing factors in the development of serious cryptococcal infections.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: T R
authors.initials: TR
authors.lastname: Frieden
authors.forename: F J
authors.initials: FJ
authors.lastname: Bia
authors.forename: P W
authors.initials: PW
authors.lastname: Heald
authors.forename: R N
authors.initials: RN
authors.lastname: Eisen
authors.forename: T F
authors.initials: TF
authors.lastname: Patterson
authors.forename: R L
authors.initials: RL
authors.lastname: Edelson
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D017893:Photopheresis / Q000009:adverse effects*
chemical_list: D000666:Amphotericin B; D008727:Methotrexate