title: Long-term corneal involvement following drug-induced toxic epidermal necrolysis (Lyell's disease).
abstract: Toxic epidermal necrolysis is a mucocutaneous disease that also causes important ocular sequelae. Conjunctival retraction, scars and sicca syndrome with severe corneal lesions are the principal ocular complications, sometimes resulting in a major handicap for the patient. We report a case where long-term sequelae ended in corneal perforation requiring a keratoplasty more than 20 years after the initial attack.
authors.affiliation: Service of Ophthalmology, University of Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Haus
authors.forename: P
authors.initials: P
authors.lastname: Paquet
authors.forename: C
authors.initials: C
authors.lastname: Maréchal-Courtois
mesh_terms: D000328:Adult; D003320:Corneal Ulcer / Q000209:etiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012422:Rupture, Spontaneous; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000209:etiology; D013449:Sulfonamides / Q000009:adverse effects
chemical_list: D013449:Sulfonamides