Localization of the human alpha-fodrin gene (SPTAN1) to 9q33-->q34 by fluorescence in situ hybridization.
Using fluorescence in situ hybridization, the human alpha-fodrin gene (nonerythroid alpha spectrin, SPTAN1), a member of the spectrin gene superfamily, was mapped to 9q33-->q34. This locus is near the translocation breakpoint region in the Philadelphia (Ph1) chromosome, t(9;22)(q34;q11). In a human chronic myelogenous leukemia cell line with the Ph1 chromosome, K562, the alpha-fodrin gene mapped centromeric to the translocation breakpoint, indicating that the alpha-fodrin gene is not translocated to the Ph1 chromosome in this cell line.
Upender
M
M
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510.
Gallagher
P G
PG
Moon
R T
RT
Ward
D C
DC
Forget
B G
BG
D002352:Carrier Proteins / Q000235:genetics*; D002460:Cell Line; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D015723:Gene Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology; D008840:Microfilament Proteins / Q000235:genetics*; D005810:Multigene Family; D013049:Spectrin / Q000235:genetics; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D008840:Microfilament Proteins; D013049:Spectrin