title: A new role for vitamin D: cholecalciferol promotes dermal wound strength and re-epithelization.
abstract: Vitamin D endocrine system is a potent regulator of cell growth and maturation. Vitamin D3 modulates growth kinetics of many cells and produces divergent actions. Keeping this in view, cholecalciferol is evaluated for its actions on dermal wound healing in Wistar rats. Intraperitonial cholecalciferol at 5, 10, 15 IU/g body weight doses produces increases in wound breaking strength and promotes epithelization significantly. Results suggest that there is some biological role for vitamin D endocrine system, ir wound repair. A clear understanding of this role of vitamin D3 may define new avenues in wound medication.
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Mangalore, India.
authors.forename: K V
authors.initials: KV
authors.lastname: Ramesh
authors.forename: M B
authors.initials: MB
authors.lastname: Mahindrakar
authors.forename: E P
authors.initials: EP
authors.lastname: Bhat
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002762:Cholecalciferol / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000293:injuries; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D002762:Cholecalciferol