ATP4- increases the intracellular calcium concentration in rat submandibular glands.
1. The intracellular calcium concentration of a crude suspension from rat submandibular glands was increased by extracellular ATP. 2. The stimulatory effect of ATP was favored by removal of magnesium from the extracellular medium. ADP and adenosine had no effect. ATP did not modify the concentration of calcium in isolated rat pancreatic acini. 3. It is concluded that ATP is a potential neurotransmitter regulating the submandibular gland function.
Dehaye
J P
JP
Department of General Biochemistry, Université libre de Bruxelles, Belgium.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002217:Carbachol / Q000494:pharmacology; D066298:In Vitro Techniques; D008274:Magnesium / Q000502:physiology; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*
D000255:Adenosine Triphosphate; D002217:Carbachol; D008274:Magnesium; D002118:Calcium