title: Infertility in carriers of two bisatellited marker chromosomes.
abstract: Two unrelated sterile patients, a male and a female, with karyotypes characterized by the presence of two supernumerary bisatellited marker chromosomes, were studied with the aid of fluorescence in situ hybridization (FISH). Using alphoid centromeric specific probes, the markers were identified as an idic (15) (pter-q11) and a mar (14). In both cases a single accessory bisatellited marker was present in the karyotype of one of the parents. A possible correlation between the excess of constitutive heterochromatin and meiotic disturbances in the two patients is discussed.
authors.affiliation: IRCCS DeBellis Castellana, Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gentile
authors.forename: F
authors.initials: F
authors.lastname: Susca
authors.forename: N
authors.initials: N
authors.lastname: Resta
authors.forename: A
authors.initials: A
authors.lastname: Stella
authors.forename: A
authors.initials: A
authors.lastname: Cascone
authors.forename: G
authors.initials: G
authors.lastname: Guanti
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D010641:Phenotype
chemical_list: D005819:Genetic Markers