Decreased insulin-like growth factor-I (IGF-I) receptor sites on circulating mononuclear cells from cows with persistent lymphocytosis.
Plasma IGF-I concentrations and IGF-I receptor binding on mononuclear cells have been studied on bovine leukemia virus (BLV)-negative (CO), BLV-infected aleukemic (AL) cows or cows with persistent lymphocytosis (PL). No significant differences in plasma IGF-I concentrations were demonstrated among the three groups of animals. However, a linear negative correlation existed between the number of circulating mononuclear cells and the number of IGF-I binding sites on these cells from control cows. In addition, mononuclear cells from PL cows had fewer IGF-I binding sites per cell when compared with control cows. These results suggest involvement of IGF-I in etiology of BLV infection and progression and warrant further studies to establish whether IGF-I plays a major physiological role in these conditions.
Zhao
X
X
Department of Animal and Poultry Science, University of Guelph, Ontario, Canada.
McBride
B W
BW
Trouten-Radford
L
L
Lissemore
K
K
D000818:Animals; D002417:Cattle; D016583:Enzootic Bovine Leukosis / Q000209:etiology / Q000378:metabolism*; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D001909:Leukemia Virus, Bovine; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008218:Lymphocytosis / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000032:analysis* / Q000502:physiology
D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1