title: Haemorrhagic bullae induced by oral anticoagulants.
abstract: A 77-year-old patient developed haemorrhagic bullae on her fingers 30 months after initiation of anti-coagulation treatment with warfarin sodium for chronic atrial fibrillation and mitral insufficiency. The bullae resolved 10 days after discontinuation of the medication. Two weeks after initiation of sintrom, (3-alpha-(4-nitrophenyl)-beta-acetylethyl-4-hydroxy coumarin), the lesions recurred and resolved again upon cessation of the drug. This adverse skin reaction has not been hitherto reported.
authors.affiliation: Department of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Elis
authors.forename: M
authors.initials: M
authors.lastname: Lishner
authors.forename: R
authors.initials: R
authors.lastname: Lang
authors.forename: H
authors.initials: H
authors.lastname: Savin
authors.forename: M
authors.initials: M
authors.lastname: Ravid
mesh_terms: D000074:Acenocoumarol / Q000009:adverse effects; D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D000074:Acenocoumarol