Reversing of chlorambucil resistance by ethacrynic acid in a B-CLL patient.
We evaluated the reversing activity of ethacrynic acid in a B-CLL patient resistant to chlorambucil. The glutathione S-transferase (GST) activity, measured in peripheral blood lymphocytes, resulted extremely elevated. Ethacrynic acid, at pharmacological concentrations, partially reversed chlorambucil resistance and this result appeared related to the increased GST levels.
Petrini
M
M
Department of Haematology, University of Pisa, Italy.
Conte
A
A
Caracciolo
F
F
Sabbatini
A
A
Grassi
B
B
Ronca
G
G
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use*; D004351:Drug Resistance; D004976:Ethacrynic Acid / Q000627:therapeutic use*; D005982:Glutathione Transferase / Q000187:drug effects; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000201:enzymology; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000201:enzymology; D008297:Male
D002699:Chlorambucil; D005982:Glutathione Transferase; D004976:Ethacrynic Acid