title: Inhibition of dihydrofolate reductase by mofebutazon.
abstract: Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. An apparent Ki for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2 mM was calculated.
authors.affiliation: Institut für Botanik und Mikrobiologie, Technische Universität München, Bundesrepublik Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Strehl
authors.forename: I
authors.initials: I
authors.lastname: Schneider
authors.forename: E F
authors.initials: EF
authors.lastname: Elstner
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005493:Folic Acid Antagonists; D007700:Kinetics; D015394:Molecular Structure; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010653:Phenylbutazone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005493:Folic Acid Antagonists; D009249:NADP; D010653:Phenylbutazone; C002374:mofebutazone