title: Export of parasite proteins to the erythrocyte in Plasmodium falciparum-infected cells.
abstract: The human malaria parasite Plasmodium falciparum invades erythrocytes and develops within a parasitophorous vacuole. It has been proposed that constitutive protein export from the intracellular parasite is mediated by two types of secretory vesicles. One is targeted to the parasite plasma membrane and the other to a domain where the plasma and vacuolar membranes of the parasite are fused into a single bilayer. This differential targeting of vesicles may be regulated by the developmental stage of the parasite. Regulated secretion through the apical organelles at or immediately after the invasion of a new red cell may allow protein insertion at the erythrocyte surface and mediate formation of the joint membrane domain of constitutive secretion.
authors.affiliation: Department of Microbiology, Stanford University, CA 94305.
authors.forename: K
authors.initials: K
authors.lastname: Haldar
authors.forename: A A
authors.initials: AA
authors.lastname: Holder
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology; D006801:Humans; D010963:Plasmodium falciparum / Q000378:metabolism*; D015800:Protozoan Proteins / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism / Q000469:parasitology
chemical_list: D015800:Protozoan Proteins