[Polymyositis and Jo-1 syndrome].
Polymyositis is a primarily clinical diagnosis. In 30-40% of patients, however, the specific anti-Jo-1 antibody (anti-histidyl-tRNA-synthetase) can be found. These cases are often associated with interstitial lung disease and other typical clinical manifestations. This symptomatology is called Jo-1-syndrome. Prognosis depends on early diagnosis, since Jo-1 associated interstitial lung disease resulting in pulmonary fibrosis is favorably influenced by immunosuppressive therapy, especially with corticosteroids. The present report concerns a patient with Jo-1-syndrome and beginning pulmonary fibrosis who was treated with methotrexate and prednisolone with good initial response. After 1 year the patient's condition had deteriorated, so that the therapy was changed to cyclophosphamide. Longterm results under this therapy remain to be evaluated.
Treher
E
E
Abteilung für Rheumatologie und Klinische Immunologie, Medizinische Universitätsklinik, Freiburg.
Niederhoff
A
A
Gellissen
U
U
Schmidt
P
P
Dornberg
M
M
Peter
H H
HH
D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000032:analysis*; D003078:Colchicine / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004008:Diclofenac / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005455:Fluorescent Antibody Technique; D006643:Histidine-tRNA Ligase / Q000276:immunology; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D009543:Nifedipine / Q000008:administration & dosage; D017285:Polymyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011239:Prednisolone / Q000008:administration & dosage; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D011928:Raynaud Disease / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D013577:Syndrome
D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody; D004008:Diclofenac; D003520:Cyclophosphamide; D011239:Prednisolone; D006643:Histidine-tRNA Ligase; D009543:Nifedipine; D003078:Colchicine; D008727:Methotrexate
Polymyositis und Jo-1-Syndrom.