Interactions between sensory neuropeptides and lipid mediators in the airways.
The local release of sensory neuropeptides from capsaicin-sensitive primary afferents elicits prominent motor and inflammatory actions in mammalian airways. This neurogenic inflammation can contribute to the pathophysiology of asthma and airway hyperreactivity. In this review evidence will be presented regarding the involvement of this peptidergic neural pathway in the mediation of some pulmonary actions of lipid mediators such as eicosanoids and PAF.
Manzini
S
S
Menarini Ricerche Sud, Pharmacology Department, Pomezia, Roma, Italy.
Perretti
F
F
Meini
S
S
D000818:Animals; D001980:Bronchi / Q000294:innervation*; D002211:Capsaicin / Q000494:pharmacology; D015777:Eicosanoids / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000294:innervation*; D009475:Neurons, Afferent / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D010972:Platelet Activating Factor / Q000502:physiology*; D015320:Tachykinins / Q000502:physiology
D015777:Eicosanoids; D009479:Neuropeptides; D010972:Platelet Activating Factor; D015320:Tachykinins; D002211:Capsaicin