title: Effects of local anaesthetics on retinal spreading depression.
abstract: This study examines the effect of two local anaesthetics, benzocaine and lidocaine, on propagation, amplitude and duration of the slow potential change of spreading depression. The experiments were performed in isolated chick retina superfused with Ringer's solution. We observed, for both drugs, a dose-related decrease in all parameters analysed. The maximal effect on propagation was blockade of the reaction.
authors.affiliation: Departamento de Farmacologia Basica e Clinica, ICB, UFRJ, Rio de Janeiro, RJ, Brasil.
authors.forename: S R
authors.initials: SR
authors.lastname: Chebabo
authors.forename: R J
authors.initials: RJ
authors.lastname: do Carmo
authors.forename: H
authors.initials: H
authors.lastname: Martins-Ferreira
mesh_terms: D000818:Animals; D001566:Benzocaine / Q000494:pharmacology*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects / Q000502:physiology*
chemical_list: D008012:Lidocaine; D001566:Benzocaine