[Gonadotropin receptor system and its signal transduction pathway].
Recent advances in genetic studies have elucidated structure of gonadotropin receptors. This transmembrane receptor contains seven transmembrane domains and induces multiple biological changes in granulosa/theca cells resulting in follicular maturation in women. The signal transduction involves G protein mediated systems, cAMP mediated systems and phospholipase C systems. This paper reviews recent advances in gonadotropin receptor system and its signal transduction pathway.
Takami
M
M
Department of Obstetrics and Gynecology, Nihon University School of Medicine.
Sakamoto
H
H
Satoh
K
K
D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011967:Receptors, Gonadotropin / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism
D011967:Receptors, Gonadotropin; D000242:Cyclic AMP; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins