title: Headache caused by a single lesion of multiple sclerosis in the periaqueductal gray area.
abstract: We report a severe acute headache that occurred in conjunction with a solitary fresh lesion of multiple sclerosis in the periaqueductal gray region of a 16-year-old girl. This unique natural event supports the recent proposition, based on observations of patients with implanted electrodes, that perturbations of the periaqueductal gray region can produce headache. It also suggests that headaches accompanying attacks of multiple sclerosis are due to disturbances in particular regions of the brain.
authors.affiliation: Department of Neurology, State University of New York, Health Science Center at Syracuse.
authors.forename: D C
authors.initials: DC
authors.lastname: Haas
authors.forename: P F
authors.initials: PF
authors.lastname: Kent
authors.forename: D I
authors.initials: DI
authors.lastname: Friedman
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000473:pathology; D003287:Contrast Media; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006261:Headache / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis; D009460:Neurologic Examination; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D010487:Periaqueductal Gray / Q000473:pathology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA