Inhibition of HIV infection by flavanoids.
Of a variety of flavanoids, the flavans were generally more effective than flavones and flavanones in selective inhibition of HIV-1, HIV-2 or SIV infection. Studies of their effects on the binding of sCD4 and antibody to gp120 indicated that the effective compounds interact irreversibly with gp120 to inactive virus infectivity and block infection.
Mahmood
N
N
MRC Collaborative Centre, London, UK.
Pizza
C
C
Aquino
R
R
De Tommasi
N
N
Piacente
S
S
Colman
S
S
Burke
A
A
Hay
A J
AJ
D015704:CD4 Antigens / Q000378:metabolism; D002478:Cells, Cultured; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D006678:HIV / Q000187:drug effects*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D015302:Simian Immunodeficiency Virus / Q000187:drug effects*; D014774:Virulence / Q000187:drug effects
D015704:CD4 Antigens; D005419:Flavonoids; D015699:HIV Envelope Protein gp120