title: Natural history of HLA expression during tumour development.
abstract: HLA expression is frequently altered in tumours compared to the tissue from which they originate. Given the central role of MHC products in the restriction of T-cell recognition, regulation of tumour HLA expression might be a strategy for the evasion of immune surveillance by the malignant cells. Federico Garrido, Peter Stern and colleagues present data from a variety of tumour types, suggesting that HLA class I alterations may occur at a particular step between the development of an in situ lesion and an invasive carcinoma.
authors.affiliation: Dept of Analisis Clínicos e Immunología, Hospital Virgen de las Nieves, Universidad de Granada, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Garrido
authors.forename: T
authors.initials: T
authors.lastname: Cabrera
authors.forename: A
authors.initials: A
authors.lastname: Concha
authors.forename: S
authors.initials: S
authors.lastname: Glew
authors.forename: F
authors.initials: F
authors.lastname: Ruiz-Cabello
authors.forename: P L
authors.initials: PL
authors.lastname: Stern
mesh_terms: D002278:Carcinoma in Situ / Q000276:immunology; D005260:Female; D015870:Gene Expression; D006680:HLA Antigens / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness / Q000276:immunology; D009369:Neoplasms / Q000209:etiology* / Q000276:immunology; D011230:Precancerous Conditions / Q000276:immunology
chemical_list: D006680:HLA Antigens