[Fatty acid composition and functional status of erythrocyte membranes in patients with sepsis].
Distinct alterations in fatty acid composition and in the functional state of erythrocyte membranes were detected in 58 patients with sepsis; these alterations were phase-dependent and correlated highly with clinical picture. Considerable increase in content of saturated and monounsaturated fatty acids and a decrease in concentration of lipoproteins were found in erythrocyte membranes under inauspicious conditions of sepsis development. In these patients activities of superoxide dismutase and glucose-6-phosphate dehydrogenase were decreased, while content of SH-groups was lowered and lipid peroxidation was inhibited. The alterations observed in fatty acid composition of erythrocyte membranes and a decrease in metabolic activity of red blood cells may be responsible for hemolysis in patients with sepsis.
Soboleva
M K
MK
Sharapov
V I
VI
D001424:Bacterial Infections / Q000097:blood*; D002675:Child, Preschool; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D005227:Fatty Acids / Q000097:blood*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D007223:Infant; D015227:Lipid Peroxidation; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood
D005227:Fatty Acids; D013438:Sulfhydryl Compounds; D005954:Glucosephosphate Dehydrogenase; D013482:Superoxide Dismutase
Zhirnokislotnyĭ sostav i funktsional'noe sostoianie éritrotsitarnykh membran u bol'nykh sepsisom.