Column-switching techniques for high-performance liquid chromatography of drugs in biological samples.
In recent years, an increasing number of publications have demonstrated the potential of column-switching techniques for the chromatographic separation, determination and preparative isolation of analytes from biological matrices. Column-switching systems greatly facilitate drug analysis, by on-line sample clean-up and trace enrichment, or by improving the analytical separative process. In this paper, the main applications of column-switching techniques to drug analysis in biological samples, are reviewed.
Campíns-Falcó
P
P
Departamento de Química Analítica, Facultad de Química, Universidad de Valencia, Burjassot, Spain.
Herráez-Hernández
R
R
Sevillano-Cabeza
A
A
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis*
D004364:Pharmaceutical Preparations