title: Relationship between antifungal activity and hydrophobicity of kojic acid derivatives.
abstract: Twenty three kojic acid derivatives were tested in the agar diffusion test against twenty five dermatophytic fungi. The inhibitory effects at equal doses (10 mg/L) were correlated with the 1-octanol-water partition coefficients of the compounds. An improvement in antifungal activity can be achieved by increasing the hydrophobicity of the compounds.
authors.affiliation: Department of Biochemical Technology, Faculty of Chemical Technology, Slovak Polytechnic University, Bratislava.
authors.forename: S
authors.initials: S
authors.lastname: Baláz
authors.forename: M
authors.initials: M
authors.lastname: Uher
authors.forename: J
authors.initials: J
authors.lastname: Brtko
authors.forename: M
authors.initials: M
authors.lastname: Veverka
authors.forename: J
authors.initials: J
authors.lastname: Bransová
authors.forename: J
authors.initials: J
authors.lastname: Dobias
authors.forename: M
authors.initials: M
authors.lastname: Pódová
authors.forename: J
authors.initials: J
authors.lastname: Buchvald
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D011753:Pyrones; C011890:kojic acid