[The comparative characteristics of the antiatherogenic effect of xymedon and parmidine].
We've studied xymedon (30 mg/kg, 12 m) and parmidin (pyridinolcarbamate 30 mg/kg, 12 m.) effects on the development of experimental cholesterol atherosclerosis on rabbits. It was demonstrated that after the use of xymedon aorta damage reduces twice. Xymedon also prevents accumulation of cholesterol and fatty degeneration of the liver. Antiatherogenic effect of xymedon resulted comparable with the effect of parmidin. As it was demonstrated in the present investigation and in the previous ones in contrast to parmidin, xymedon normalizes the lipoproteins balance owing to increase of HDL cholesterol. It also has regenerative activity on endotheliocytes and immunomodulator properties. That can be of great importance for the anti-atherosclerotic effects of the medicine.
Kamburg
R A
RA
Ibragimov
O B
OB
Kondrat'eva
M B
MB
Valeeva
I Kh
IKh
Shamsutdinov
N Sh
NSh
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008297:Male; D011727:Pyridinolcarbamate / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D002791:Cholesterol, Dietary; D008055:Lipids; D011743:Pyrimidines; C069705:xymedon; D011727:Pyridinolcarbamate
Sravnitel'naia kharakteristika antiaterogennogo éffekta ksimedona i parmidina.