title: IgA, IgG, and anti-Pasteurella multocida antibody levels in bursectomized and/or cyclophosphamide-treated turkeys after CU vaccination.
abstract: In bursectomized, cyclophosphamide-treated, and bursectomized/cyclophosphamide-treated turkeys, IgA, IgG, and anti-Pasteurella multocida were determined before and after vaccination with the Clemson University (CU) strain of P. multocida. Before vaccination, the average total serum level of IgA was significantly (P < 0.05) lower in bursectomized and bursectomized/cyclophosphamide-treated turkeys than in untreated controls, and the average serum levels of anti-P. multocida were significantly (P < 0.05) lower in bursectomized, cyclophosphamide-treated, and bursectomized/cyclophosphamide-treated turkeys than in untreated controls. After vaccination, average serum IgA levels were still significantly (P < 0.05) lower in all treated groups of turkeys than in the untreated controls. Also after vaccination, total IgG increased significantly (P < 0.05) only in the bursectomized turkeys, and serum anti-P. multocida antibody levels increased significantly (P < 0.05) in cyclophosphamide-treated, bursectomized/cyclophosphamide-treated, and untreated turkeys. After challenge with virulent P. multocida, survivability was significantly (P < 0.05) lower in the three treated groups of turkeys than in the untreated groups.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211.
authors.forename: G T
authors.initials: GT
authors.lastname: Schlink
authors.forename: L D
authors.initials: LD
authors.lastname: Olson
authors.forename: Y M
authors.initials: YM
authors.lastname: Saif
authors.forename: D J
authors.initials: DJ
authors.lastname: Jackwood
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D001428:Bacterial Vaccines / Q000494:pharmacology; D002060:Bursa of Fabricius / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D010326:Pasteurella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology* / Q000517:prevention & control; D014422:Turkeys / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D003520:Cyclophosphamide