title: Concentrations of cytokines in peritoneal fluid after abdominal surgery.
abstract: OBJECTIVE
  To assess the role of concentrations of cytokines in peritoneal fluid in estimating the severity of the host's response to the stress of abdominal operations.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University hospital, Japan.
  
  
  METHODS
  49 patients who underwent various abdominal operations. Main outcome measures--Correlations between concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) in peritoneal fluid measured on the first postoperative day on the one hand, and peritoneal bacterial count, length of operation, and operative blood loss, on the other.
  
  
  RESULTS
  The concentrations of all three peritoneal cytokines correlated significantly with length of operation; those of TNF-alpha and IL-1 beta also correlated significantly with peritoneal bacterial count, and that of IL-1 beta with operative blood loss. There were significant correlations between the concentrations of the three cytokines.
  
  
  CONCLUSIONS
  These correlations suggest that monitoring of the peritoneal concentrations of TNF-alpha, IL-1 beta, and IL-6 may be helpful in estimating the severity of stress caused by abdominal operations.
authors.affiliation: Department of Surgery I, Gunma University, School of Medicine, Maebashi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsukada
authors.forename: H
authors.initials: H
authors.lastname: Katoh
authors.forename: M
authors.initials: M
authors.lastname: Shiojima
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Takenoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Nagamachi
mesh_terms: D000005:Abdomen / Q000601:surgery*; D001202:Ascitic Fluid / Q000276:immunology* / Q000382:microbiology; D016063:Blood Loss, Surgical; D015169:Colony Count, Microbial; D016207:Cytokines / Q000032:analysis*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013312:Stress, Physiological / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha