[Thyrotropin secreting adenoma].
Thyrotropin (TSH)-secreting pituitary tumor (TSHoma) is a very rare condition and is characterized by elevated serum thyroid hormone and unsuppressed TSH levels. Although in most patients, TSH and thyroid hormone levels are high, in several cases they are within normal range. There are several similar conditions such as, TSH secreting pituitary hyperplasia. Refetoff syndrome and so on. It is very difficult to differentiate these conditions. Hypersecretion of alpha subunit is a characteristic commonly seen only in TSHoma. Surgical excision is the first choice of treatment for this tumor but the prognosis is not good. Octreotide is a very useful drug that suppresses the TSH level.
Kamio
M
M
Department of Neurosurgery, Jikei University School of Medicine.
D000236:Adenoma / Q000378:metabolism* / Q000628:therapy; D001971:Bromocriptine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D015282:Octreotide / Q000627:therapeutic use; D010902:Pituitary Gland / Q000601:surgery; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000628:therapy; D013972:Thyrotropin / Q000378:metabolism*
D001971:Bromocriptine; D013972:Thyrotropin; D015282:Octreotide