title: [Biological effects of substances similar to salicylanilides. 3-aryl-2H, 4H-benz(e)(1,3)oxazine-2, 4-diones and thiosalicylanilides].
abstract: The review paper is the first collected communication about the biological activity of 3-aryl-2H,4H-benz(e)(1,3)oxazine-2,4-diones and thiosalicylanilides. The substances of the above mentioned structures show a number of biological activities (antibacterial, antituberculous, antimycotic, anthelmintic, molluscocidal, neuroleptic, analgesic and anti-inflammatory) which can be modelled by structural changes. Only very few of them have been hitherto introduced into practice as anthelmintic agents, or agents with a special purpose (destroying the sea lamprey in Canadian lakes). In the group of 3-aryl-2H,3H-benz(e)(1,3)-oxazine-2,4-diones, i.e. substances developed from salicylanilides by the action of alkyl-chloroformiates, antibacterial activity is reported in refs. 3-12, antituberculous activity in refs. 13, 14, antimycotic activity in refs. 5, 6, 9, 12, 15, 16, anthelmintic activity in refs. 6,917-20, molluscocidal activity in refs. 6, 21, analgesic and anti-inflammatory activity in refs. 22-24, herbicidal activity in refs. 25, 26, allergenic activity in ref. 27. In the group of salicylanilides, antibacterial activity is reported in refs. 28-37, antimycotic activity in refs. 28-36, antiprotozoal activity in ref. 35, anthelmintic activity in refs. 28-40, 49, molluscocidal activity in refs. 7, 28-36. The present paper furthermore sums up the papers concerned with the toxicities of the above-mentioned agents. Though the peak of research of the groups of the above-mentioned structure was in the 1960s and 1970s, papers investigating their biological activity can be encountered also at present.
authors.affiliation: Katedra anorganické a organické chemie farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
authors.forename: K
authors.initials: K
authors.lastname: Waisser
authors.forename: L
authors.initials: L
authors.lastname: Kubicová
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D010078:Oxazines / Q000737:chemistry; D012458:Salicylanilides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010078:Oxazines; D012458:Salicylanilides
vernacular_title: Biologické úcinky látek podobných salicylanilidům. 3-aryl-2h, 4h-benz(e)(1,3)oxazin-2, 4-diony a thiosalicylanilidy.