Enhancement of the antitrichomonal activity of 5-nitroimidazole derivatives by hydrogen peroxide.
The in vitro sensitivity of nine Trichomonas vaginalis isolates to commonly employed 5-nitroimidazoles (metronidazole, nimorazole, ornidazole and tinidazole) was evaluated in absence and in presence of sub-inhibitory concentrations of hydrogen peroxide (H2O2). Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the strains exhibiting cross-resistance to these drugs. It was suggested that H2O2 produced in the inflammatory process during trichomonal infection could enhance the therapeutic effect of 5-nitroimidazole drugs.
Mattana
A
A
Istituto di Chimica Biologica, Facoltà di Farmacia, Università di Sassari, Italy.
Juliano
C
C
Picci
V
V
Franconi
F
F
Cappuccinelli
P
P
D000818:Animals; D000994:Antitrichomonal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000994:Antitrichomonal Agents; D009593:Nitroimidazoles; D006861:Hydrogen Peroxide