Fetal H-2 odortypes are evident in the urine of pregnant female mice.
The major histocompatibility complex (MHC) imparts to each mouse an individual urinary odor, called "odortype", which reflects its MHC genotype. Perception of odortypes affects mate selection and embryonic implantation. Recent findings that odortypes are expressed as early as one day of age suggested that they might already be expressed in utero. We now report that at 9-12 days of gestation, odortypes specified by paternal (non-maternal) MHC haplotypes become apparent in maternal urine. Thus, odortypes are expressed in utero, can be sensed even before birth, and may serve in familial identification and communication.
Beauchamp
G K
GK
Monell Chemical Senses Center, Philadelphia, PA 19104.
Yamazaki
K
K
Curran
M
M
Bard
J
J
Boyse
E A
EA
D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009812:Odorants; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000652:urine*
D006183:H-2 Antigens