title: Effect of hydroxypropyl-beta-cyclodextrin on efficacy of oral itraconazole in disseminated murine cryptococcosis.
abstract: The therapeutic efficacy of itraconazole solubilized in either the commonly used vehicle, polyethylene-glycol-200 (PEG) or hydroxypropyl beta-cyclodextrin was compared in a murine model of disseminated cryptococcosis. Itraconazole at doses of up to 120 mg/kg/day solubilized in PEG were found not to be effective. However, itraconazole at doses > or = 30 mg/kg/day solubilized in hydroxypropyl-beta-cyclodextrin markedly prolonged survival and a relationship between dose and survival was seen.
authors.affiliation: Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128.
authors.forename: J S
authors.initials: JS
authors.lastname: Hostetler
authors.forename: L H
authors.initials: LH
authors.lastname: Hanson
authors.forename: D A
authors.initials: DA
authors.lastname: Stevens
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D003453:Cryptococcosis / Q000188:drug therapy* / Q000382:microbiology; D003505:Cyclodextrins / Q000494:pharmacology*; D005079:Excipients; D005260:Female; D017964:Itraconazole / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D011092:Polyethylene Glycols; D012996:Solutions; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D005079:Excipients; D012996:Solutions; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D017964:Itraconazole; D011092:Polyethylene Glycols