[The effect of antibody to Streptococcus mutans in saliva on caries activity and S. mutans adhering].
An indirect enzyme-linked immunosorbent assay (ELISA) was used for measuring IgA antibody to whole cell of Streptococcus mutans (serotype c) in saliva. 36 parotid salivary samples of human were collected from two groups: Caries free (CF) and caries sensitive (CS). The result shows that the IgA antibody to S. mutans in CF group was higher than those in CS group (P < 0.05). The saliva antibody was gained from the rabbits by injection with S. mutans (serotype c), and the adhesion of S. mutans--3H on the surface of hydroxylapatite beads treated by rabbit's saliva was measured. The results show that the saliva with immunity could inhibit the S. mutans to adhere on the HA beads (P < 0.05). It means saliva antibody may prevent caries through inhibition of S. mutans from adhesion.
Luo
Z L
ZL
College of Stomatology, West China University of Medical Sciences, Chendu.
D000328:Adult; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D001422:Bacterial Adhesion; D003731:Dental Caries / Q000276:immunology* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D011817:Rabbits; D012463:Saliva / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology / Q000502:physiology*
D000907:Antibodies, Bacterial; D007071:Immunoglobulin A, Secretory