title: [DNCG (acecromol) and ketotifen (Zatofug) in treatment of children with bronchial asthma].
abstract: In an open clinical study, 80 children and adolescents of 12 months to 20 years of age suffering from asthma bronchiale were treated for a minimum of 8 weeks with DNCG (acecromol) or ketotifen (Zatofug) or with both drugs. Both under the treatment with DNCG and with ketotifen the overall disease pattern was improved with a large proportion of the patients and the concurrent adjuvant medication with prednisolone and/or aminophyllin could be markedly reduced or in some cases discontinued altogether. Both substances appear to be comparable as far as the therapy result is concerned; however, the range of application of ketotifen is wider due to its additional antihistaminic action and oral administration, e.g. in case of concomitant urticaria or food allergy.
authors.affiliation: Universitäts-Kinderklinik, Friedrich-Schiller-Universität Jussuf Ibrahim, Jena.
authors.forename: M
authors.initials: M
authors.lastname: Kehnscherper
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007665:Ketotifen / Q000008:administration & dosage*; D008297:Male
chemical_list: D004205:Cromolyn Sodium; D007665:Ketotifen
vernacular_title: DNCG (acecromol) und Ketotifen (Zatofug) in der Behandlung von Kindern mit Asthma bronchiale.