Fluconazole-induced toxic epidermal necrolysis in a patient with human immunodeficiency virus infection.
Patients with human immunodeficiency virus (HIV) infection are prone to severe drug reactions, mainly from sulfonamides. We report the case of a 33-year-old male patient with HIV infection (group IV C-2 of CDC staging system) that developed a toxic epidermal necrolysis (TEN) affecting more than 70% of the body surface area and severe mucosal involvement after starting fluconazole for a recurrent oral thrush with dysphagia. This is to our knowledge the first reported case of TEN due to fluconazole.
Azón-Masoliver
A
A
Department of Dermatology, Hospital de Sant Joan, Reus, Spain.
Vilaplana
J
J
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000328:Adult; D002180:Candidiasis, Oral / Q000188:drug therapy; D015725:Fluconazole / Q000009:adverse effects* / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D015725:Fluconazole