Segregation of cerebrorubral and cerebellorubral synaptic inputs on rubrospinal neurons of fetal cats as demonstrated by intracellular recording.
Cerebrorubral and cerebellorubral inputs are localized to distal dendrites and somata of red nucleus neurons in adult cats, respectively. To examine if this segregation is established early in development, we performed intracellular recording from rubrospinal neurons of fetal cats aged from embryonic day 58 to 65. Stimulation of the contralateral cerebellar nuclei evoked excitatory postsynaptic potentials (EPSPs). EPSPs were also induced by stimulation of the ipsilateral pericruciate cortext but they were much slower in time course and smaller in amplitude compared to cerebellar ones. We suggest that cerebrorubral and cerebellorubral synapses are segregated on soma-dendritic membrane of rubrospinal neurons early in development.
Song
W J
WJ
Department of Biophysical Engineering, Faculty of Engineering Science, Osaka University, Japan.
Kanda
M
M
Ohno
T
T
Kanda
M
M
Oikawa
H
H
Murakami
F
F
D000818:Animals; D002415:Cats; D002529:Cerebellar Nuclei / Q000166:cytology / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D003712:Dendrites / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D011247:Pregnancy; D012012:Red Nucleus / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D013569:Synapses / Q000502:physiology*