title: Effect of some chemical radioprotectors on mouse bone marrow.
abstract: Effect of HT, AET and Se on mice bone marrow has been studied by counting bone marrow micronucleated cells and endogenous spleen colony count (CFU-S). Combination of HT and AET used as a radioprotector has not caused any significant variation in any of the parameter studied when administered once, it increases bone marrow micronucleated cells and decreases CFU-S slightly after daily administration for 7 days. The individual constituent of the combination administered singly does not increase micronucleated cell number. Seven consecutive doses of HT + AET and same in combination with Se enhances micronucleated cells to a higher level. Daily injection of Se alone up to 7 days also causes an increase in micronucleated cells upto same level. CFU-S pool does not show any significant change in number of bone marrow cells through out the study except in the groups where animals were treated with Se.
authors.affiliation: Radiation Biology Department, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Lata
authors.forename: A
authors.initials: A
authors.lastname: Ghose
authors.forename: C M
authors.initials: CM
authors.lastname: Khanna
mesh_terms: D006916:5-Hydroxytryptophan / Q000008:administration & dosage; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012643:Selenium / Q000008:administration & dosage; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage
chemical_list: D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D006916:5-Hydroxytryptophan; D012643:Selenium