[A comparison of the effects of cyproheptadine and propranolol on the development of poststressor lesions of the gastric mucosa in inbred mice].
The effects of central cyproheptadine and propranolol were virtually the same but differed in their intensity. Differences between genotypes were shown to be able to determine the differences in effects of the blocking agents on different kinds of stress-induced stomach damage. The data obtained suggest that genotypic properties of the serotoninergic system can interfere considerably with the reactions of the stomach mucosa to emotional stress.
Koriakina
L A
LA
D000818:Animals; D003404:Creatinine / Q000008:administration & dosage; D003533:Cyproheptadine / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D005753:Gastric Mucosa / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology / Q000503:physiopathology; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D012149:Restraint, Physical; D012701:Serotonin / Q000008:administration & dosage; D013276:Stomach Ulcer / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology
D004338:Drug Combinations; C014050:creatinine sulfate, serotonin drug combination; D003533:Cyproheptadine; D012701:Serotonin; D011433:Propranolol; D003404:Creatinine
Sopostavlenie éffektov tsiprogeptadina i propranolola na razvitie poststressornykh porazheniĭ slizistoĭ zheludka u inbrdnykh mysheĭ.