title: Lambert-Eaton myasthenic syndrome associated with Sjögren's syndrome and discoid lupus erythematosus.
abstract: A 65-year-old woman with facial erythema and hypergammaglobulinemia developed excessive fatigability. A diagnosis of Lambert-Eaton myasthenic syndrome (LEMS) was made from electrophysiological studies. She had symptoms and laboratory data compatible with probable Sjögren's syndrome. Skin biopsy revealed the histological findings of discoid lupus erythematosus. Treatment with 3,4-diaminopyridine resulted in the improvement of fatigability. LEMS should be recognized as a treatable complication of systemic autoimmune diseases.
authors.affiliation: Department of Medicine and Physical Therapy, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Uesaka
authors.forename: N
authors.initials: N
authors.lastname: Kurose
authors.forename: M
authors.initials: M
authors.lastname: Haida
authors.forename: J
authors.initials: J
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D000368:Aged; D001706:Biopsy; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000175:diagnosis; D008179:Lupus Erythematosus, Discoid / Q000150:complications* / Q000473:pathology; D012796:Sialography; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis; D012867:Skin / Q000473:pathology