Benzodiazepines for intravenous conscious sedation: agonists and antagonists.
Benzodiazepines, including diazepam and midazolam, have proved to be safe and effective for intravenous conscious sedation. Their selective anxiolytic activity and wide margin of safety contribute to their popularity. The recent introduction of the benzodiazepine receptor antagonist, flumazenil, provides flexibility and added safety for intravenous benzodiazepine sedation.
Finder
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RL
Department of Anesthesiology, University of Pittsburgh, School of Dental Medicine, Pennsylvania.
Moore
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PA
D000766:Anesthesia, Dental / Q000379:methods*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology*; D016292:Procedural Sedation / Q000379:methods*; D003975:Diazepam / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology; D005442:Flumazenil / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008140:Lorazepam / Q000493:pharmacokinetics / Q000494:pharmacology; D008874:Midazolam / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology
D001569:Benzodiazepines; D005442:Flumazenil; D008140:Lorazepam; D003975:Diazepam; D008874:Midazolam