title: Heparin induced thrombosis: an important complication of heparin prophylaxis for thromboembolic disease in surgery.
abstract: Heparin induced thrombocytopenia with thrombosis, or the "white clot syndrome," is a rare but recognised complication of heparin therapy. The syndrome is idiosyncratic, immune mediated, and not dose dependent and therefore is equally likely to occur with prophylactic and therapeutic heparin dosage regimens. Despite published reports on the subject we were alarmed that many surgeons who regularly use heparin to prevent or treat thrombosis were unaware that heparin can induce thrombotic complications in susceptible patients. We present three typical case histories, a brief discussion of the condition, and some guidelines on its prevention and treatment.
authors.affiliation: Department of Orthopaedic and Accident Surgery, Queen's Medical Centre, Nottingham.
authors.forename: J B
authors.initials: JB
authors.lastname: Hunter
authors.forename: R J
authors.initials: RJ
authors.lastname: Lonsdale
authors.forename: P W
authors.initials: PW
authors.lastname: Wenham
authors.forename: S P
authors.initials: SP
authors.lastname: Frostick
mesh_terms: D000368:Aged; D005260:Female; D005268:Femoral Vein; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011300:Preoperative Care / Q000009:adverse effects*; D011859:Radiography; D013921:Thrombocytopenia / Q000139:chemically induced*; D013923:Thromboembolism / Q000517:prevention & control; D013927:Thrombosis / Q000139:chemically induced* / Q000000981:diagnostic imaging
chemical_list: D006493:Heparin