Common mechanisms for the control of eukaryotic transcriptional elongation.
Regulation of transcriptional elongation is emerging as an important control mechanism for eukaryotic gene expression. In this essay, we review the basis of the current view of the regulation of elongation in the human c-myc gene and discuss similarities in elongation control among the c-myc, Drosophila hsp70 and the HIV-1 genes. Based upon these similarities, we propose a model for control of expression of these genes at the elongation phase of transcription. This model suggests that distinct promoter elements direct the assembly of RNA polymerase II transcription complexes which differ in their elongation efficiency.
Krumm
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Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Meulia
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Groudine
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D000818:Animals; D010582:Bacteriophage lambda / Q000235:genetics; D001483:Base Sequence; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004330:Drosophila / Q000235:genetics; D005057:Eukaryotic Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D015696:Gene Products, tat / Q000502:physiology; D016259:Genes, myc; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D012367:RNA, Viral / Q000096:biosynthesis; D012045:Regulatory Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014158:Transcription, Genetic; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D006360:Heat-Shock Proteins; D012333:RNA, Messenger; D012367:RNA, Viral; D054322:tat Gene Products, Human Immunodeficiency Virus; D012321:DNA-Directed RNA Polymerases