Influence of pretreatment of carbamates on dynamic pulmonary mechanics in rats exposed to sarin aerosols.
The effect of pretreatment of two carbamates, pyridostigmine and physostigmine on dynamic pulmonary mechanics has been studied in rats exposed to sarin aerosols. Sign-free dose of pyridostigmine (0.075 mg/kg, i.m.) or physostigmine (0.1 mg/kg, i.m.) did not significantly alter the parameters of the dynamic pulmonary mechanics 20 min after treatment. However, sarin (51.2 mg/m3, for 15 min) depressed the respiratory rate, air flow and minute volume and enhanced the transthoracic pressure and tidal volume. Pretreatment with carbamates 20 min prior to sarin exposure significantly modified or counteracted the above induced changes. It is concluded that the protective effect of carbamates is mainly due to the correction of respiratory changes caused by sarin aerosols in rats.
Husain
K
K
Division of Pharmacology and Toxicology, Defence R & D Establishment, Gwalior.
Kumar
P
P
Vijayaraghavan
R
R
Singh
R
R
Das Gupta
S
S
D000336:Aerosols; D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D011729:Pyridostigmine Bromide / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015656:Respiratory Mechanics / Q000187:drug effects*; D012524:Sarin / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity
D000336:Aerosols; D002219:Carbamates; D010830:Physostigmine; D012524:Sarin; D011729:Pyridostigmine Bromide