Induction of differentiation and growth suppression of myeloid leukemia cells by sera of patients with hematological disorders.
In severe infection, the host responds to foreign agents and produces cytokines to activate lymphocytes and macrophages. Some of these cytokines can modulate growth and differentiation of myeloid leukemia cells. We examined differentiation-inducing activities in the sera from 9 patients with leukemia or lymphoma. These results indicate that some sera from infected patients, even with acute leukemia, have significant differentiation-inducing activities on both mouse and human leukemia cells, and that cytokines having differentiation-inducing activities varied for different specimens.
Kanatani
Y
Y
Department of Chemotherapy, Saitama Cancer Center Research Institute, Japan.
Honma
Y
Y
Tsuchimochi
T
T
Okabe-Kado
J
J
Nagata
N
N
Motoyoshi
K
K
Hozumi
M
M
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology*; D006402:Hematologic Diseases / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D007951:Leukemia, Myeloid / Q000473:pathology*; D051379:Mice
D016207:Cytokines