Susceptibilities to rimantadine of influenza A/H1N1 and A/H3N2 viruses isolated during the epidemics of 1988 to 1989 and 1989 to 1990.
Clinical isolates of influenza A viruses identified during outbreaks in two winters were tested for their rimantadine susceptibilities by an enzyme-linked immunosorbent assay modified from that described previously by Belshe et al. (R. B. Belshe, B. Burk, F. Newman, R. L. Cerruti, and I. S. Sim, J. Virol. 62:1508-1512, 1988). The infectivity titer and the 50% inhibitory concentration of rimantadine were calculated for each virus. Of 105 influenza virus A isolates tested, 28 influenza A/H1N1 isolates from the 1988 and 1989 outbreak and 77 influenza A/H3N2 isolates from the outbreak in following year, were susceptible to the antiviral action of rimantadine.
Valette
M
M
Laboratoire de Virologie, Universite Claude Bernard-Lyon 1, France.
Allard
J P
JP
Aymard
M
M
Millet
V
V
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000187:drug effects* / Q000276:immunology; D007251:Influenza, Human / Q000453:epidemiology* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D012299:Rimantadine / Q000494:pharmacology*; D013997:Time Factors; D014709:Vero Cells
D000956:Antigens, Viral; D012299:Rimantadine