title: Craniospinal irradiation for trilateral retinoblastoma following ocular irradiation.
abstract: A case study is presented. Craniospinal radiotherapy and a three-fold pineal boost for trilateral retinoblastoma were delivered to a patient previously irradiated for ocular retinoblastoma. The availability of CT-based three-dimensional treatment planning provided the capability of identifying the previously irradiated volume as a three-dimensional anatomic structure and of designing a highly customized set of treatment beams that minimized reirradiation of that volume.
authors.affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: L B
authors.initials: LB
authors.lastname: Marks
authors.forename: G
authors.initials: G
authors.lastname: Bentel
authors.forename: G W
authors.initials: GW
authors.lastname: Sherouse
authors.forename: D P
authors.initials: DP
authors.lastname: Spencer
authors.forename: K
authors.initials: K
authors.lastname: Light
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005134:Eye Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy; D010870:Pineal Gland / Q000187:drug effects / Q000528:radiation effects; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012175:Retinoblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D013120:Spinal Cord Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*