Effects of oxygen radicals, hydrogen peroxide and water-soluble singlet oxygen carriers on 5- and 12-lipoxygenase.
Inhibition of 5-lipoxygenase from bovine polymorphonuclear leukocytes and 12-lipoxygenase from bovine platelets by active oxygen species has been studied. Oxygen radicals and hydrogen peroxide markedly inhibited 12-lipoxygenase, whereas 5-lipoxygenase activity was only moderately influenced. Singlet oxygen liberated from water-soluble naphthalene endoperoxides was without effect.
Müller
K
K
Institute of Pharmacy, University of Regensburg, Germany.
Ziereis
K
K
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002417:Cattle; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000494:pharmacology*
D006893:Hydroxyeicosatetraenoic Acids; D016859:Lipoxygenase Inhibitors; D017382:Reactive Oxygen Species; D007975:Leukotriene B4; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D006861:Hydrogen Peroxide