Inhibition of dihydrofolate reductase by mofebutazon.
Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. An apparent Ki for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2 mM was calculated.
Strehl
E
E
Institut für Botanik und Mikrobiologie, Technische Universität München, Bundesrepublik Deutschland.
Schneider
I
I
Elstner
E F
EF
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005493:Folic Acid Antagonists; D007700:Kinetics; D015394:Molecular Structure; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010653:Phenylbutazone / Q000031:analogs & derivatives* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005493:Folic Acid Antagonists; D009249:NADP; D010653:Phenylbutazone; C002374:mofebutazone