Biliary elimination and pharmacokinetics of vinorelbine in micropigs.
The biliary elimination and pharmacokinetics of vinorelbine (NVB) were investigated in five conscious micropigs provided with a double-terminal choledocal fistula allowing the collection and reinstillation of bile. After the i.v. administration of NVB (0.5 mg/kg), serum and bile samples were collected over a 48-h period. The concentrations of NVB were measured by high-performance liquid chromatography. The serum concentrations decreased rapidly from a maximal value of 208.6 ng/ml (SD, 111.7 ng/ml). The mean half-life was 10.9 h (SD, 8.6 h) and the mean AUC0-48 h was 292.8 ng ml-1 h (SD, 79.4 ng ml-1 h). The bile concentrations were high, amounting to 16.0 micrograms/ml (range, 5.4-27.7 micrograms/ml). The 0- to 48-h biliary excretion of unchanged NVB accounted for 25.8% (SD, 5.7%) of the injected dose, with 21.5% (SD, 4.0%) being eliminated during the 0- to 8-h period. Desacetyl-NVB was found in an inconstant manner and in very low amounts in bile samples. In addition, no glucuronide of NVB could be detected. Thus, in the micropig, biliary excretion represents an important route of elimination for NVB.
Levêque
D
D
Laboratory of Pharmacokinetics, Institute of Bacteriology, Strasbourg, France.
Merle-Melet
M
M
Bresler
L
L
Didelot
J P
JP
Aymard
J P
JP
Wihlm
J
J
Jehl
F
F
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D013552:Swine; D013556:Swine, Miniature; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D014747:Vinblastine; D000077235:Vinorelbine