Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25.
The 3'-end of the cDNA encoding the smg GDP dissociation stimulator (smg GDS) protein shares 100% homology with the previously published expressed sequence tag 00038 site. This site extends the 3'-end of the smg GDS gene by 212 bp. It has been localized to human chromosome 4. Here, we have refined the localization of smg GDP to human chromosome 4q21-q25 using a mapping panel of rodent/human somatic cell hybrids containing different parts of chromosome 4. This chromosomal localization of smg GDP to 4q21-25 overlaps with a region of allele loss in primary hepatocellular carcinoma (4q13-q26).
Riess
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Abteilung für Molekulare Humangenetik, Ruhr Universität, Bochum, Germany.
Epplen
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Siedlaczck
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Epplen
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D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D005656:Fungal Proteins / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D009841:Oligonucleotides; D016133:Polymerase Chain Reaction; D017385:Sequence Homology; D020668:rap GTP-Binding Proteins
D005656:Fungal Proteins; D009841:Oligonucleotides; D019204:GTP-Binding Proteins; D020668:rap GTP-Binding Proteins