[Effects of n-3 polyunsaturated fatty acids on the cardiovascular system. Should their use be recommended?].
The effects of n-3 polyunsaturated fatty acid (n-3 PFA) intake on lipoprotein metabolism, eicosanoid metabolism, coagulation and the fibrinolytic system, mediators of inflammation, and blood pressure are discussed. The possible role such effects may have on the process of atherogenesis is examined. Laboratory animal studies with n-3 PFA supplements are reviewed. Finally, a review of clinical and epidemiological studies in human subjects is made in order to evaluate whether the experimental findings have clinical relevance. The conclusion is that, at the present time, there is insufficient support for the use of n-3 PFA supplements either in prophylaxis or in treating ischemic cardiopathy.
Lahoz
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C
Unidad de Arterioesclerosis, Instituto de Salud Carlos III, Madrid.
Mata
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P
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000502:physiology; D006801:Humans
D015525:Fatty Acids, Omega-3
Efectos de los ácidos grasos poliinsaturados n-3 sobre el sistema cardiovascular. Se debe recomendar su uso?