Clinical evaluation of a rapid immunoinhibition assay for creatine kinase-MB in suspected myocardial infarction.
We examined the clinical performance of a new immunoinhibition assay (INH) for the measurement of creatine kinase isoenzyme MB (CK-MB). In 196 consecutive patients admitted for exclusion of acute myocardial infarction, serial blood samples were evaluated by INH, immunoradiometric assay (IRMA), and electrophoresis (ELP). Using receiver operating characteristic curve analysis, the diagnostic performance of the INH assay was comparable to IRMA and ELP. As compared with these alternative methodologies, this newly available INH assay for CK-MB provides similar diagnostic accuracy and increased convenience at a greatly reduced cost.
Mego
D M
DM
Cardiology Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.
Pupa
L E
LE
Bailey
S R
SR
D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase; D004586:Electrophoresis; D006801:Humans; D007124:Immunoenzyme Techniques; D015592:Immunoradiometric Assay; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors
D015415:Biomarkers; D007527:Isoenzymes; D003402:Creatine Kinase