title: Leukonychia totalis in two sibs.
abstract: A sister and a brother, offspring of unaffected consanguineous Arab parents, were found to have leukonychia totalis and flat, wide nails. To our knowledge this is the first report of apparent autosomal recessive transmission of this trait. A parental somatic mutation with gonadal mosaicism may explain the unusual segregation of the trait in this family.
authors.affiliation: Department of Pediatrics, Hasharon Hospital, Petah Tiqwa, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Frydman
authors.forename: H A
authors.initials: HA
authors.lastname: Cohen
mesh_terms: D002648:Child; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000235:genetics*