title: IC101, extracellular matrix antagonist produced by Streptomyces sp. MJ202-72F3. Production, isolation, structure determination and biological activity.
abstract: In our search for inhibitors of cell adhesion to components of extracellular matrix (ECM), fibronectin, laminin and collagen type IV, we succeeded in finding a novel cyclic hexadepsipeptide antibiotic, named IC101, which was isolated from cultured mycelium of Streptomyces albulus MJ202-72F3. It was purified by centrifugal partition chromatography, preparative reverse phase HPLC and Sephadex LH-20 and was obtained as a white powder. IC101 strongly inhibited cell adhesion to ECM components, suppressed immune responses in vitro and in vivo, and exhibited antimicrobial activity on Gram-positive bacteria.
authors.affiliation: Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ueno
authors.forename: M
authors.initials: M
authors.lastname: Amemiya
authors.forename: T
authors.initials: T
authors.lastname: Someno
authors.forename: T
authors.initials: T
authors.lastname: Masuda
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Ishizuka
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D016326:Extracellular Matrix Proteins / Q000187:drug effects*; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D010455:Peptides; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D016326:Extracellular Matrix Proteins; D010455:Peptides; D010456:Peptides, Cyclic; C085032:IC 101