title: [The behavioral effects of beta-casomorphin-7 and its des-Tyr analogs].
abstract: The effects of intraperitoneal administration of the heptapeptide beta-casomorphin-7 (beta-K-7) and its des-Tyr analogues (beta-K-6 and beta-K-4) on spontaneous locomotor activity were investigated in rats using "Opto-Varimax", "RODEO-2" and "open field" tests. At 20 mg/kg 5 minutes prior to the beginning of measurements beta-K-7 produced a significant decrease in linear locomotion and rearing. As for beta-K-6 and beta-K-4, their influence on locomotion of the experimental animals was less evident. In contrast to beta-K-7, its des-Tyr analogues (20 mg/kg) produced a marked decrease in nose-poking behavior. Beta-K-7 in doses that had no effect on spontaneous behaviour (1 and 5 mg/kg) attenuated extreme behavioural displays under stress conditions. The experimental results suggest the advisability of further investigations of neurotropic properties of beta-K-7 and related peptides.
authors.forename: A S
authors.initials: AS
authors.lastname: Maklakova
authors.forename: V A
authors.initials: VA
authors.lastname: Dubynin
authors.forename: N H
authors.initials: NH
authors.lastname: Levitskaia
authors.forename: V N
authors.initials: VN
authors.lastname: Nezavibat'ko
authors.forename: L A
authors.initials: LA
authors.lastname: Alfeeva
authors.forename: A A
authors.initials: AA
authors.lastname: Kamenskiĭ
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002364:Caseins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D002364:Caseins; D004723:Endorphins; D010446:Peptide Fragments; C041128:beta-casomorphin 7; C059556:beta-casomorphin, des-Tyr-
vernacular_title: Povedencheskie éffekty beta-kazomorfina-7 i ego dez-Tyr-analogov.