title: Quercetin potentiates TNF-induced antiviral activity.
abstract: Tumor necrosis factor (TNF) produces a dose-dependent inhibition of vesicular stomatitis virus (VSV), encephalomyocarditis virus (EMCV), and herpes simplex virus type 1 (HSV-1) replication in WISH cells. The antiviral activity of TNF against VSV and EMCV is greatly enhanced by combination with quercetin. Induction of 2',5'-oligo-adenylate (2-5A) synthetase by TNF is also enhanced by quercetin. Addition of polyclonal antibodies to human interferon (IFN)-beta completely blocked both enhancement of antiviral activity and 2-5A synthetase induction.
authors.affiliation: Department of Epidemiology, National Institute of Health, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Ohnishi
authors.forename: H
authors.initials: H
authors.lastname: Bannai
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004357:Drug Synergism; D004686:Encephalomyocarditis virus / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D014409:Tumor Necrosis Factor-alpha; D011794:Quercetin