The inter-relationship of factor VII and its activity state with plasma lipids in healthy male adults.
A close inter-relationship between raised factor VII clotting activity and elevated blood lipids, particularly serum triglycerides, is well established. A study of factor VII, its activation state and of plasma lipids has been undertaken in two groups of healthy middle-aged males to elucidate this mechanism. A control group with normal factor VII levels were closely matched for age and body-mass index with a second group with elevated levels. Factor VII assays, using rabbit and bovine thromboplastin and a factor VII Ag method, were employed. Triglycerides correlated with the rabbit factor VII thromboplastin assay and factor VII Ag (P < 0.05) but not with the bovine thromboplastin method. Higher HDL-cholesterol and apolipoprotein A-I levels were found in subjects with increased factor VII (P < 0.001) and appeared to be due to differences in alcohol consumption. Cholesterol levels were significantly higher with elevated factor VII. Differential testing suggests that higher factor VII is predominantly mediated through a rise in total VII, rather than an increase in its activity state.
Wright
D
D
UK Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester.
Poller
L
L
Thomson
J M
JM
Gowland
E
E
Burrows
G E
GE
D000328:Adult; D000941:Antigens / Q000032:analysis; D001053:Apolipoproteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005167:Factor VII / Q000032:analysis* / Q000276:immunology; D015942:Factor VIIa / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D000941:Antigens; D001053:Apolipoproteins; D008055:Lipids; D014280:Triglycerides; D005167:Factor VII; D002784:Cholesterol; D015942:Factor VIIa