title: X-linked agammaglobulinemia--gene cloning and future prospects.
abstract: The btk gene has recently been identified as the causative gene in X-linked agammaglobulinemia (XLA). This has opened up many new possibilities for the treatment of this B-cell immunodeficiency. Christine Kinnon and colleagues review the high degree of sequence of homology of btk to the non-receptor tyrosine kinases and speculate on putative roles for this gene in B-cell development.
authors.affiliation: Molecular Immunology Unit, University of London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Kinnon
authors.forename: S
authors.initials: S
authors.lastname: Hinshelwood
authors.forename: R J
authors.initials: RJ
authors.lastname: Levinsky
authors.forename: R C
authors.initials: RC
authors.lastname: Lovering
mesh_terms: D000077329:Agammaglobulinaemia Tyrosine Kinase; D000361:Agammaglobulinemia / Q000235:genetics*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D005544:Forecasting; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology; D014960:X Chromosome
chemical_list: D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human