Association of cutaneous mast cells and sensory nerves with psychic stress in psoriasis.
Association of stress with psoriatic skin symptoms was studied in 13 patients with psoriasis by dividing the patients into low- and high-stress groups based on their clinical examination and answers to three questionnaires (General Health Questionnaire, a somatization scale, and a life change questionnaire). This study focused on skin mast cells and sensory nerves which are the principal components in neurogenic inflammation. Mast cells were stained enzyme-histochemically for tryptase and chymase, and neuropeptides substance P (SP), vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) were demonstrated immunohistochemically. Compared to the low-stress group (n = 7), the patients in the high-stress group (n = 6) had more severe skin and joint symptoms. Furthermore, mast cells positive for chymase activity were prominently reduced, but tryptase-positive mast cells only slightly decreased in the lesional skin of the high-stress group. A similar tendency was also observed in the nonlesional skin. In the papillary dermis of the lesional skin, both VIP- and CGRP-immunoreactive nerves could be observed in the high-stress group whereas in the low-stress group these nerve fibers were hardly visible in the corresponding area. No association of SP with stress was observed. This study suggests that psychic stress is associated with exacerbation of psoriasis, and stress may induce alterations in the psoriatic lesions by increasing the neuropeptide content with a concomitant decrease in the activity of neuropeptide-degrading enzymes, especially mast cell chymase.
Harvima
I T
IT
Department of Dermatology, University of Kuopio, Finland.
Viinamäki
H
H
Naukkarinen
A
A
Paukkonen
K
K
Neittaanmäki
H
H
Harvima
R J
RJ
Horsmanheimo
M
M
D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D008875:Middle Aged; D009479:Neuropeptides / Q000502:physiology; D010555:Personality Inventory; D011565:Psoriasis / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D011602:Psychophysiologic Disorders / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D011984:Sensory Receptor Cells / Q000502:physiology*; D012867:Skin / Q000294:innervation*; D013001:Somatoform Disorders / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D013315:Stress, Psychological / Q000150:complications*
D009479:Neuropeptides