Inhibition of cholinergic neurotransmission in isolated guinea-pig main bronchi by SR 48968.
SR 48968 (10(-6) to 10(-5) M) inhibited the cholinergic response of the isolated guinea-pig main bronchus to electrical field stimulation. Since this effect was reversed by naloxone 10(-5) M and since SR 48968 had no effect on the contractile response to exogenous acetylcholine, we conclude that SR 48968 acts at a prejunctional level and that opioid receptors are involved. This effect was observed at concentrations approximately 75,000 times higher than those needed for blockade of tachykinin NK2 receptors.
Martin
C A
CA
Laboratoire de Pharmacologie, Faculté de Médecine Paris-Ouest, France.
Emonds-Alt
X
X
Advenier
C
C
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001980:Bronchi / Q000294:innervation*; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology*; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors*; D009435:Synaptic Transmission / Q000187:drug effects*
D001549:Benzamides; D010880:Piperidines; D018039:Receptors, Tachykinin; C073839:SR 48968; D009020:Morphine