Hyperprolactinaemia and infertility following cranial irradiation for brain tumours: successful treatment with bromocriptine.
Two young women developed oligomenorrhoea and galactorrhoea 4 and 7 years after whole brain irradiation for brain tumours. Both had mild hyperprolactinaemia due to irradiation-induced hypothalamic damage. In both patients, oral bromocriptine normalized prolactin levels and menstruation resumed. One patient then had a successful pregnancy.
Petterson
T
T
Mersey Regional Department of Neurological Sciences, Walton Hospital, Liverpool, UK.
MacFarlane
I A
IA
Foy
P M
PM
Hughes
H J
HJ
Jones
B
B
Shaw
D
D
D000293:Adolescent; D001932:Brain Neoplasms / Q000532:radiotherapy*; D001971:Bromocriptine / Q000627:therapeutic use*; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D005909:Glioblastoma / Q000532:radiotherapy; D005910:Glioma / Q000532:radiotherapy; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000209:etiology*; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology*; D009839:Oligomenorrhea / Q000209:etiology; D011832:Radiation Injuries / Q000188:drug therapy / Q000209:etiology*
D001971:Bromocriptine