title: Effect of iron deficiency on the digestive utilization of iron, phosphorus, calcium and magnesium in rats.
abstract: The influence of the source of dietary Fe (ferric citrate alone or mixed with bovine blood at a proportion of 1:1 (v/v)) on the digestive utilization of Fe, P, Ca and Mg, and on haemoglobin regeneration efficiency (HRE) was investigated in control and Fe-deficient rats. Diet A contained (by analysis) 43.5 mg Fe/kg diet (as ferric citrate), and diet B contained 44.3 mg Fe/kg diet (ferric citrate-bovine blood). In Fe-deficient rats fed on diet A or B the apparent digestibility coefficient (ADC) of Fe increased by 42.3 and 45.7% respectively. The ADC of Ca and Mg decreased significantly in Fe-deficient rats regardless of the source of dietary Fe. The HRE increased by 72.9% in Fe-deficient rats fed on diet A, and by 91.1% in Fe-deficient animals fed on diet B. In Fe-deficient rats fed on Fe for 10 d the values of haematological variables approached normality. However, serum Fe remained low, indicating that Fe reserves were still depleted. A deficient dietary supply of Fe for 30 d did not significantly modify the numbers of circulating leucocytes.
authors.affiliation: Departamento de Fisiología, Facultad de Farmacia, Universidad de Granada, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Pallarés
authors.forename: F
authors.initials: F
authors.lastname: Lisbona
authors.forename: I L
authors.initials: IL
authors.lastname: Aliaga
authors.forename: M
authors.initials: M
authors.lastname: Barrionuevo
authors.forename: M J
authors.initials: MJ
authors.lastname: Alférez
authors.forename: M S
authors.initials: MS
authors.lastname: Campos
mesh_terms: D000818:Animals; D001682:Biological Availability; D001772:Blood Cell Count; D001835:Body Weight; D002118:Calcium / Q000378:metabolism*; D004032:Diet; D004063:Digestion; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000378:metabolism; D000090463:Iron Deficiencies; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006454:Hemoglobins; D010758:Phosphorus; D007501:Iron; D008274:Magnesium; D002118:Calcium