Protective effect of loratadine on late phase reaction induced by conjunctival provocation test.
The protective effect of Loratadine, a new generation, non-sedating antihistamine, on clinical and cellular events during the early phase reaction (EPR) and late phase reaction (LPR) of the allergen-specific conjunctival provocation test (CPT) was assessed out of the pollen season in 20 seasonally allergic rhino-conjunctivitis patients. After a screening CPT, selected patients were randomized to Loratadine (10 mg OD) or matching placebo for 7 days. CPT was repeated following treatment. Clinical and cellular responses were evaluated by a symptom score and cell counting in conjunctival scrapings before, and 30 min and 6 h after challenge with allergen (one eye) or placebo (control eye). Conjunctival symptom severity following CPT was reduced at 30 min (EPR) and 6 h (LPR) after CPT in the Loratadine group compared to placebo group (p < 0.01), as was the total number of inflammatory cells (p < 0.001). In conclusion, Loratadine protects against the clinical and cellular EPR and LPR events consequent to CPT, showing antiallergic properties.
Ciprandi
G
G
Department of Internal Medicine, University of Genoa, Italy.
Buscaglia
S
S
Marchesi
E
E
Danzig
M
M
Cuss
F
F
Canonica
G W
GW
D000485:Allergens / Q000276:immunology; D003228:Conjunctiva / Q000276:immunology; D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D006801:Humans; D007159:Immunologic Tests; D017336:Loratadine / Q000627:therapeutic use*; D013997:Time Factors
D000485:Allergens; D017336:Loratadine