Effects of alprazolam on influenza virus infection in stressed mice.
The review of the literature shows that stress can adversely affect influenza A virus infection. In this report, we study the effects of chronic alprazolam (1 mg/kg/day), a central benzodiazepine agonist anxiolytic, on the influenza A (PR-8/34) virus specific immune injury in mice exposed to a chronic auditory stressor. Treatment with alprazolam resulted in a significant reduction of stress-induced increase of virus titters and pulmonary vascular permeability. A correlation with the lethality of mice was also observed.
Freire-Garabal
M
M
Neuroimmunology-University of Santiago (NIMUS), Hospital de Conxo, Santiago de Compostela, Spain.
Balboa
J L
JL
Fernandez-Rial
J C
JC
Núñez
M J
MJ
Belmonte
A
A
D000161:Acoustic Stimulation / Q000009:adverse effects; D000525:Alprazolam / Q000494:pharmacology*; D000818:Animals; D002199:Capillary Permeability / Q000502:physiology; D009980:Influenza A virus / Q000472:pathogenicity; D008168:Lung / Q000382:microbiology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000401:mortality / Q000523:psychology*; D011650:Pulmonary Alveoli / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications / Q000401:mortality / Q000523:psychology*; D015996:Survival Rate
D000525:Alprazolam