[Therapeutic efficacies of neticonazole (SS717) cream and solution in experimental cutaneous Candida albicans infection of guinea pigs].
The therapeutic efficacies of 1% neticonazole (SS717) cream and solution on experimental cutaneous Candida albicans infection produced in prednisolone-treated guinea pigs were compared with those of 1% bifonazole (BFZ). Active preparations or blank vehicles were applied once daily for 3 consecutive days starting 5 days postinfection. Therapeutic effects were assessed on the basis of viable counts recovered from the infected loci 9 days postinfection. In animals treated with SS 717 or BFZ cream, a significant mycological improvement was observed when compared to untreated controls. A significant therapeutic efficacy of a SS717 cream compared to cream vehicle was also noted, while there was no significant difference in the recovery of Candida between the untreated control group and the cream vehicle-treated groups. The mycological result of the SS717 solution treated group was significantly superior to those of the untreated control group, the solution vehicle-treated group and the BFZ solution-treated group. The treatment with a solution vehicle or a BFZ solution appeared to lower, though not to a significant level, viable counts at the infected loci. These results led us to the conclusion that both SS717 cream and solution preparations exhibited significantly superior activity to that of BFZ in experimental cutaneous candidasis of guinea pigs.
Maebashi
K
K
Teikyo University Research Center for Medical Mycology.
Itoyama
T
T
Uchida
K
K
Yamaguchi
H
H
Asaoka
T
T
Iwasa
A
A
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002179:Candidiasis, Cutaneous / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D012996:Solutions
D000935:Antifungal Agents; D007093:Imidazoles; D009824:Ointments; D012996:Solutions; C084784:neticonazole; C036596:bifonazole