title: Usefulness of dobutamine echocardiography for detecting restenosis after percutaneous transluminal coronary angioplasty.
abstract: To determine the usefulness of dobutamine stress echocardiography for detecting restenosis after percutaneous transluminal coronary angioplasty, the results of coronary arteriography and dobutamine stress echocardiography were compared in 103 patients 6 months after percutaneous transluminal coronary angiography. The dobutamine stress echocardiograms were obtained on the same day as the coronary arteriograms, which were analyzed by both quantitative and visual estimates of luminal narrowing. The angiographic restenosis rate was 44% by quantitative and 31% by visual estimates of stenosis. Dobutamine stress echocardiography was abnormal in 38% of previously dilated regions with restenosis and normal in 79% of previously dilated regions without restenosis by quantitative coronary angiography. Dobutamine stress echocardiography was concordant in 69% of 16 patients with multivessel disease compared with 40% of 41 patients with 1-vessel disease (p < 0.05). By quantitative coronary angiography, 64% of patients with significant disease in the left anterior descending artery were identified by dobutamine stress echocardiography compared to 12 and 24% of patients with disease in the left circumflex and right coronary arteries, respectively (p < 0.009). Concordance was seen in 79% of patients with baseline wall motion abnormalities compared with 54% of patients without baseline wall motion abnormalities. Dobutamine stress echocardiography has a low sensitivity but high specificity for detecting restenosis after coronary angioplasty, which may be explained in part by the high prevalence of 1-vessel disease in this patient population. The variables associated with significantly higher degrees of concordance were the presence of left anterior descending artery disease, multivessel disease, and baseline wall motion abnormalities.
authors.affiliation: Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: S K
authors.initials: SK
authors.lastname: Heinle
authors.forename: E B
authors.initials: EB
authors.lastname: Lieberman
authors.forename: M
authors.initials: M
authors.lastname: Ancukiewicz
authors.forename: R A
authors.initials: RA
authors.lastname: Waugh
authors.forename: T M
authors.initials: TM
authors.lastname: Bashore
authors.forename: J
authors.initials: J
authors.lastname: Kisslo
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D004280:Dobutamine; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011859:Radiography; D012008:Recurrence; D012680:Sensitivity and Specificity
chemical_list: D004280:Dobutamine