Effects of systemic administration of 6-hydroxydopamine, 6-hydroxydopa and 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP) on tuberoinfundibular dopaminergic neurons in the rat.
Using systemic route of administration, the effects of several neurotoxins on hypothalamic tuberoinfundibular dopaminergic neurons were focused in this study. 6-Hydroxydopamine (6-OHDA, 10 or 100 mg/kg b.wt., i.v. or ip) produced a dose (37 vs. 50%)- and time (41 to 29% from day 4 to day 9)-dependent depletion of hypothalamic median eminence dopamine concentrations, and increases of serum prolactin levels in ovariectomized rats. Other central dopaminergic neurons, however, were not significantly affected. Similar treatments with 6-hydroxydopa (6-OHDOPA) were less effective. On the other hand, treatments of 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP, 10 mg/kg b.wt./day, ip) for 7 or 14 days produced significant decreases of dihydroxyphenylacetic acid (DOPAC) levels in the median eminence and periventricular regions, and increases in serum prolactin levels. Other central dopaminergic neurons were not significantly affected, though. These results suggest that systemic administration of 6-OHDA, 6-OHDOPA, or MPTP, can produce specific destructive effects on the tuberoinfundibular dopaminergic neurons.
Lin
J Y
JY
Institute of Physiology, National Yang-Ming Medical College, Taipei, Taiwan, ROC.
Mai
L M
LM
Pan
J T
JT
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats
C001388:6-hydroxydopa; D004295:Dihydroxyphenylalanine; D016627:Oxidopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine