Computed tomography and neurological soft signs in obsessive-compulsive disorder.
Computed tomography was used to compare the following three groups: obsessive-compulsive disorder (OCD) patients with high scores on a soft neurological sign examination, OCD patients with low soft neurological sign scores, and control subjects. Neuranatomical structures were measured using quantitative volumetric analysis. OCD patients with high soft sign scores had significantly increased ventricular volumes compared with OCD patients with low soft sign scores and control subjects. Caudate and lenticular nucleus volumes did not differ between groups.
Stein
D J
DJ
College of Physicians and Surgeons, Columbia University, New York, NY.
Hollander
E
E
Chan
S
S
DeCaria
C M
CM
Hilal
S
S
Liebowitz
M R
MR
Klein
D F
DF
D000328:Adult; D001921:Brain / Q000002:abnormalities*; D002421:Caudate Nucleus / Q000002:abnormalities*; D002552:Cerebral Ventricles / Q000002:abnormalities*; D003342:Corpus Striatum / Q000002:abnormalities; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000209:etiology*; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D014057:Tomography, X-Ray Computed / Q000379:methods*