[Experimental method and clinical significance of hidden rheumatoid factors].
Hidden rheumatoid factor (HRF) was detected in rheumatoid arthritis (RA) serum with ELISA after separation and dissociation of immune complex (IC). It was found that 60% of the patients with active RA has positive latex fixation test, whereas 96% of them has been demonstrated to have IgM hidden rheumatoid factor (HIgMRF) and 70% of them IgG hidden rheumatoid factor (HIgGRF). When the disease was controlled, HIgMRF and HIgGRF was found in 24% and 12% respectively. The difference was significant with P < 0.01. Our results show that the presence of HRF in RA patients is related with the activity of the disease, but not with duration of disease, sex and age.
Liu
S
S
Xuanwu Hospital, Beijing.
Liu
G R
GR
Zhou
Y
Y
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D012217:Rheumatoid Factor / Q000097:blood*; D016706:Still's Disease, Adult-Onset / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor