HLA associations with Menière's disease.
In order to investigate the genetic background of Menière's disease, histocompatibility (HLA) antigens in Japanese patients were studied. HLA-class I: HLA-A, -B and -C were typed by the classical microcytotoxicity technique, and HLA-class II: HLA-DR, DQ, and DP were typed by PCR-DNA typing methods. Twenty patient samples tested were selected very strictly following clinical data and classical criteria. Most of the patients had been suffering from typical symptoms during a considerably long period of time (16 +/- 7 years). Normal controls were based on the gene frequency in the Japanese population. Compared with the normal controls, a higher frequency of the DRB1*1602 subtype of HLA-DR2 was found in the patient group (chi 2 = 9,21, p < 0.04). P-values were corrected by multiplying by the total number of antigens. Additionally, HLA-Cw4 was increased, although the p-value was not significant after multiple antigen correction. There was no obvious relationship between the HLA-DRB1*1602 patients and the clinical data that included severity, age at time of onset, etc.
Koyama
S
S
UCLA Tissue Typing Laboratory, UCLA School of Medicine.
Mitsuishi
Y
Y
Bibee
K
K
Watanabe
I
I
Terasaki
P I
PI
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D006680:HLA Antigens; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II