Degradation products of streptozotocin do not induce hyperglycemia in rats.
The present study was conducted to determine whether degradation products of streptozotocin formed under various conditions induce hyperglycemia in rats. Streptozotocin is completely degraded in pH 7.4 buffer in 4 hr and even more rapidly in plasma. Streptozotocin degradation products resulting from incubation in pH 7.4 phosphate buffer or in plasma were not diabetogenic in rats.
Lee
J Y
JY
College of Pharmacy, Seoul National University, Korea.
Kim
M J
MJ
Moon
C K
CK
Chung
J H
JH
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006863:Hydrogen-Ion Concentration; D006943:Hyperglycemia / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D013997:Time Factors
D001786:Blood Glucose; D013311:Streptozocin