In vitro antiproliferative effect of interferon alpha in solid tumors: a potential predictive test.
An in vitro test for the antiproliferative effect of human leukocyte interferon (IFN-alpha) was performed in primary cultures of tumor cells obtained from 32 patients with either malignant melanoma (13), renal carcinoma (4) or bladder carcinoma (15). Our results demonstrated activity of IFN in all three groups of solid tumors. However, appreciable differences in sensitivity to antiproliferative effect of IFN between individual tumors of the same type were found. The potential of this antiproliferative test for prediction of treatment response in IFN-therapy is discussed.
Fuchsberger
N
N
Institute of Virology, Slovak Academy of Sciences, Bratislava.
Kubes
M
M
Kontsek
P
P
Borecký
L
L
Hornák
M
M
Godál
A
A
Silvanová
Svec
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000633:toxicity*; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery
D004273:DNA, Neoplasm; D016898:Interferon-alpha; D013936:Thymidine