Generalized melanosis with malignant melanoma metastasizing to skin--a pathological study with S-100 protein and HMB-45.
A patient with primary malignant melanoma localized to the right gluteal region is described. Four years later and after intercurrent influenza, disseminated metastases of malignant melanoma to the skin occurred. After a further 6 months melanodermia developed and lasted until the death of the patient (6 months later). Autopsy revealed melanosis of the visceral organs. Histology taken from internal organs using S-100 protein and HMB-45 melanoma methods confirmed metastases of malignant melanoma to the skin, oral cavity, palatal tonsils, nasal and nasopharyngeal mucosae, lungs, myocardium and brain. The authors discuss the mechanism of melanosis--a rare sign in patients with metastasizing malignant melanoma.
Péc
J
J
Department of Dermatovenereology and Pathological Anatomy, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
Plank
L
L
Mináriková
E
E
Palencárová
E
E
Rollová
Y
Y
Lazárová
Z
Z
Auxtová
S
S
Lauko
L
L
D002081:Buttocks; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology / Q000556:secondary*; D008548:Melanosis / Q000473:pathology*; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*