Effect of some chemical radioprotectors on mouse bone marrow.
Effect of HT, AET and Se on mice bone marrow has been studied by counting bone marrow micronucleated cells and endogenous spleen colony count (CFU-S). Combination of HT and AET used as a radioprotector has not caused any significant variation in any of the parameter studied when administered once, it increases bone marrow micronucleated cells and decreases CFU-S slightly after daily administration for 7 days. The individual constituent of the combination administered singly does not increase micronucleated cell number. Seven consecutive doses of HT + AET and same in combination with Se enhances micronucleated cells to a higher level. Daily injection of Se alone up to 7 days also causes an increase in micronucleated cells upto same level. CFU-S pool does not show any significant change in number of bone marrow cells through out the study except in the groups where animals were treated with Se.
Lata
M
M
Radiation Biology Department, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Ghose
A
A
Khanna
C M
CM
D006916:5-Hydroxytryptophan / Q000008:administration & dosage; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012643:Selenium / Q000008:administration & dosage; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D006916:5-Hydroxytryptophan; D012643:Selenium