title: Haptoglobin polymorphism and the immune response after hepatitis B vaccination.
abstract: One hundred healthy Caucasian medical students (age 22 +/- 1 years) were vaccinated with a recombinant hepatitis B vaccine and their haptoglobin types were determined. A relationship between haptoglobin type and immune response to the vaccine was observed. Subjects with a 2-2 haptoglobin phenotype produced significantly lower hepatitis B antibody titres than those having a 1-1 or 2-1 haptoglobin phenotype. The haptoglobin phenotypes not only influenced the magnitude but also the kinetics of the anti-HBs response. For all haptoglobin types, haptoglobin concentration and immune response to the vaccine behaved independently.
authors.affiliation: University Hospital Gent, Central Laboratory, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Louagie
authors.forename: J
authors.initials: J
authors.lastname: Delanghe
authors.forename: I
authors.initials: I
authors.lastname: Desombere
authors.forename: M
authors.initials: M
authors.lastname: De Buyzere
authors.forename: P
authors.initials: P
authors.lastname: Hauser
authors.forename: G
authors.initials: G
authors.lastname: Leroux-Roels
mesh_terms: D000328:Adult; D000917:Antibody Formation / Q000502:physiology; D004592:Electrophoresis, Starch Gel; D005260:Female; D006242:Haptoglobins / Q000235:genetics* / Q000502:physiology; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006801:Humans; D007700:Kinetics; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D014611:Vaccination
chemical_list: D006242:Haptoglobins; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines