Dextromethorphan O-demethylation polymorphism in Jordanians.
The O-demethylation of dextromethorphan (DMT) to dextrorphan (DRP) was studied in 241 unrelated, healthy Jordanian volunteers (171 males, 70 females). Urine was collected for 8 h following a single oral dose of DMT bromhydrate 30 mg. A thin-layer chromatographic (TLC) technique was used to identify the metaboliser phenotype. The frequency of the poor metaboliser phenotype was found to be 2.9% (approximate 95% confidence interval 0.8-5.0%). Applying the Hardy-Weinberg Law, the frequency of the recessive autosomal gene controlling poor metabolism was 0.17 (95% confidence interval 0.108-0.232).
Irshaid
Y M
YM
Department of Pharmacology, Faculty of Medicine, University of Science and Technology, Irbid, Jordan.
al-Hadidi
H F
HF
Rawashdeh
N M
NM
D000293:Adolescent; D000328:Adult; D002855:Chromatography, Thin Layer; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D003915:Dextromethorphan / Q000378:metabolism* / Q000652:urine; D003917:Dextrorphan / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D007597:Jordan; D008297:Male; D008875:Middle Aged; D010090:Oxidoreductases, O-Demethylating / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D011110:Polymorphism, Genetic
D003917:Dextrorphan; D003915:Dextromethorphan; D003577:Cytochrome P-450 Enzyme System; D010090:Oxidoreductases, O-Demethylating; C052861:dextromethorphan O-demethylase