title: Human T-cell leukaemia virus type I and neurological disease.
abstract: Tropical spastic paraparesis is thought to be caused either directly by human T-cell leukaemia virus type I (HTLV-1), or by the immune response to the virus. Recent work has identified differences between tropical spastic paraparesis patients and healthy carriers of HTLV-I, both in the virus and in the host's T-cell response to the virus. These differences may provide clues to the pathogenesis of tropical spastic paraparesis.
authors.affiliation: Department of Virology, John Radcliffe Hospital, University of Oxford, Headington, UK.
authors.forename: C R
authors.initials: CR
authors.lastname: Bangham
mesh_terms: D002353:Carrier State / Q000276:immunology / Q000382:microbiology; D015481:HTLV-I Antibodies / Q000032:analysis; D015368:Human T-lymphotropic virus 1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000382:microbiology* / Q000503:physiopathology
chemical_list: D015481:HTLV-I Antibodies