Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma.
Nuclear retinoic acid receptors RAR alpha, RAR beta and RAR gamma are transcription factors that bind all-trans retinoic acid as their ligand and mediate its action by activating particular set of genes that contain retinoic acid responsive elements in their promoter-enhancers. We have mapped genetic loci for these genes using restriction fragment length variants (RFLVs) in interspecific backcross mice. None of the Rar loci cosegregated with each other or with the new subclass of retinoid receptors, Rxr loci. Rara mapped to mChr 11, Rarb mapped to mChr 14, and Rarg mapped to mChr 15. The results are consistent with the previous reports and the human data in terms of syntenic homology between mouse and human chromosomes.
Taketo
M
M
Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
Hoopes
C
C
Howard
T A
TA
Linney
E
E
Seldin
M F
MF
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D006239:Haplotypes; D051379:Mice; D008809:Mice, Inbred C3H; D018168:Receptors, Retinoic Acid / Q000235:genetics*
D018168:Receptors, Retinoic Acid