Amides and formamidines with antinociceptive activity (note I).
Pursuing our investigations on N-aryl or N-cycloalkyl substituted amides and formamidines with antiinflammatory and/or analgesic activity, two set of cycloalkyl substituted amides and formamidines were prepared and tested for analgesic activity against a chemical stimulus. Some compounds, particularly the amides 7, 11, 17 and the formamidine 35 proved to be endowed with this activity.
Boatto
G
G
Istituto di Analitica Farmaceutica, Università di Sassari, Italy.
Cerri
R
R
Palomba
M
M
Pau
A
A
Nicolai
M
M
Sparatore
F
F
Demontis
M P
MP
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice
D000577:Amides; D000578:Amidines; D000700:Analgesics; C077922:formamidine