Effect of cimetidine on adenohypophysis of male albino mice under certain experimental condition.
Effect of 75 mg/kg of body weight of cimetidine administered intraperitoneally daily for 14 days to two groups of experimental animals (one of the experimental group was having intact testis and another group was bilaterally orchidectomized) was observed on cell population & cell volume of gonadotrophs and lactotrophs in pituitary gland, as it has not been studied earlier. In the experimental group of intact testis, there was significant reduction in the cell population of FSH cells in the cephalomedian area (P < 0.001) and in the lateral lobe (P < 0.01); the volume of both FSH and LH cells was also significantly reduced. In group 4 and group 5 there was significant increase in the population of lactotrophs and also in the volume of LH cells, FSH cells & lactotrophs. The change in the gonadotrophs in group 2 was due to increased production of testosterone from hypertrophied Leydig cells of testis rather then it's direct effect on adenohypophysis; in group 4 and group 5 the changes were due to lack of testosterone as in those cases bilaterally orchidectomy already done.
Chakraborty
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Department of Anatomy, Kasturba Medical College, Mangalore.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis; D007985:Leydig Cells / Q000187:drug effects; D007986:Luteinizing Hormone / Q000096:biosynthesis; D008297:Male; D051379:Mice; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development
D002927:Cimetidine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone