Haptoglobin polymorphism and the immune response after hepatitis B vaccination.
One hundred healthy Caucasian medical students (age 22 +/- 1 years) were vaccinated with a recombinant hepatitis B vaccine and their haptoglobin types were determined. A relationship between haptoglobin type and immune response to the vaccine was observed. Subjects with a 2-2 haptoglobin phenotype produced significantly lower hepatitis B antibody titres than those having a 1-1 or 2-1 haptoglobin phenotype. The haptoglobin phenotypes not only influenced the magnitude but also the kinetics of the anti-HBs response. For all haptoglobin types, haptoglobin concentration and immune response to the vaccine behaved independently.
Louagie
H
H
University Hospital Gent, Central Laboratory, Belgium.
Delanghe
J
J
Desombere
I
I
De Buyzere
M
M
Hauser
P
P
Leroux-Roels
G
G
D000328:Adult; D000917:Antibody Formation / Q000502:physiology; D004592:Electrophoresis, Starch Gel; D005260:Female; D006242:Haptoglobins / Q000235:genetics* / Q000502:physiology; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006801:Humans; D007700:Kinetics; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D014611:Vaccination
D006242:Haptoglobins; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines