Localization of the retinoid X receptor alpha gene (RXRA) to chromosome 9q34.
The retinoid X receptor alpha is one of a number of retinoic acid receptors which are members of the steroid/thyroid hormone superfamily. Localization of RXRA was achieved using the polymerase chain reaction on a panel of somatic cell hybrids. A cosmid clone was isolated using the RXRA PCR product, and this was used to further localize the gene by fluorescence in situ hybridization to chromosome 9q34 distal to the dopamine beta hydroxylase gene (DBH). This mapping position was confirmed by PCR on a panel of translocation hybrids.
Jones
K A
KA
Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London.
Fitzgibbon
J
J
Woodward
K J
KJ
Goudie
D
D
Ferguson-Smith
M A
MA
Povey
S
S
Wolfe
J
J
Solomon
E
E
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D003001:Cloning, Molecular; D003360:Cosmids; D017931:DNA Primers; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D012176:Retinoids / Q000378:metabolism; D014157:Transcription Factors
D017931:DNA Primers; D018160:Receptors, Cytoplasmic and Nuclear; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D012176:Retinoids; D014157:Transcription Factors; D004299:Dopamine beta-Hydroxylase