title: Expression of the mucosal T cell integrin alpha M290 beta 7 by a major subpopulation of dendritic cells in mice.
abstract: Dendritic interdigitating cells isolated from lymph nodes, Langerhans' cells from skin and dendritic cells from the spleen have been tested for expression of the mucosal T cell integrin alpha M290 beta 7. Almost all interdigitating cells isolated from mesenteric lymph nodes expressed the integrin at high levels; 50-60% of those from lymph nodes draining non-mucosal sites also expressed this adhesion molecule. In contrast, alpha M290 beta 7 was not detected on either Langerhans' cells or splenic dendritic cells. Because this integrin has recently been shown to recognize a ligand that seems to be expressed mainly or exclusively by epithelial cells; it is proposed that this adhesion pathway may be important for antigen sampling by dendritic cells in mucosal tissues.
authors.affiliation: Department of Immunology, AFRC Babraham Institute, Cambridge GB.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kilshaw
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000737:chemistry*; D016023:Integrins / Q000032:analysis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000737:chemistry; D013601:T-Lymphocytes / Q000737:chemistry*
chemical_list: D016023:Integrins