title: Areal differences in oxygen supply to a cornea wearing an optically powered hydrogel contact lens.
abstract: If there is little lateral diffusion of oxygen in an optically powered hydrogel contact lens, then point-to-point differences in the thickness of the lens can result in different areas of the cornea receiving different amounts of oxygen. Specifically, areas under the thicker portions of the lens will receive less oxygen. Cells in these oxygen-deprived areas may produce metabolic products that spread laterally in the cornea resulting in cornea-wide edema. The fact that most of a contact lens transmits adequate oxygen to the cornea does not lead to satisfactory lens performance, if some part of the lens is too thick. We address the problem of lateral diffusion of oxygen in a contact lens and describe the methods for quantifying the point-to-point thickness of optically powered hydrogel lenses. Areal differences in oxygen supply to the cornea are found to be almost totally dependent on optical power; water content and lens design have far less effect.
authors.affiliation: School of Optometry, University of California, Berkeley 94720.
authors.forename: I
authors.initials: I
authors.lastname: Fatt
authors.forename: B A
authors.initials: BA
authors.lastname: Weissman
authors.forename: C M
authors.initials: CM
authors.lastname: Ruben
mesh_terms: D003261:Contact Lenses; D003315:Cornea / Q000378:metabolism*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008433:Mathematics; D008954:Models, Biological; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D010100:Oxygen