Histamine H2-receptor plays only a minor role in histamine-induced wheal response in the squirrel monkey and guinea pig.
We examined the contribution of the histamine H2-receptor to the histamine-induced wheal response in squirrel monkeys and guinea pigs. Intradermal injection of histamine, 2-pyridylethylamine (a selective H1-agonist), and dimaprit (a selective H2-agonist) dose-dependently induced the wheal response in squirrel monkeys and guinea pigs, although the reaction to dimaprit was much weaker than that to the other agonists. Chlorpheniramine dose-dependently depressed the wheal response in squirrel monkeys and guinea pigs at doses of 0.03-1 mg/kg and 0.03-3 mg/kg, p.o., respectively. However, famotidine, ranitidine and cimetidine had no effect at doses up to 30, 100 and 300 mg/kg, p.o. in guinea pigs and up to 1, 10 and 400 mg/kg, p.o. in squirrel monkeys, respectively. Cimetidine (3-300 mg/kg, p.o.) dose-dependently potentiated the inhibitory effects of chlorpheniramine (0.1 mg/kg, p.o.) in guinea pigs, but had no effects in squirrel monkeys. Famotidine and ranitidine did not alter the response to chlorpheniramine in either animal. These results suggest that the histamine H2-receptor plays only a minor role in the histamine-induced wheal response in squirrel monkeys and guinea pigs.
Yuki
H
H
Neuroscience Research Laboratory, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
Miyata
K
K
Kamato
T
T
Nishida
A
A
Ito
H
H
Takeda
M
M
Honda
K
K
D000818:Animals; D002744:Chlorpheniramine / Q000008:administration & dosage / Q000494:pharmacology; D017259:Dimaprit / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015738:Famotidine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D017442:Histamine Agonists / Q000008:administration & dosage / Q000494:pharmacology; D007271:Injections, Intradermal; D008297:Male; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology; D011899:Ranitidine / Q000008:administration & dosage / Q000494:pharmacology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000378:metabolism*; D012453:Saimiri; D014581:Urticaria / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism
D017442:Histamine Agonists; D011725:Pyridines; D011970:Receptors, Histamine H2; D002744:Chlorpheniramine; D015738:Famotidine; D006632:Histamine; D011899:Ranitidine; C006183:2-(2-aminoethyl)pyridine; D017259:Dimaprit