title: Manganese dipyridoxal diphosphate-enhanced magnetic resonance imaging in the evaluation of hepatocyte function.
abstract: OBJECTIVE
  To determine whether contrast-enhanced magnetic resonance imaging can detect ethanol hepatotoxicity in rats.
  
  
  METHODS
  Rats were treated with a single high dose of ethanol (acute) intraperitoneally or with a 36% ethanol diet (chronic) for up to 5.5 months. Magnetic resonance imaging was performed before and after intravenous administration of manganese dipyridoxal diphosphate (Mn-DPDP).
  
  
  RESULTS
  Enhancement (acute group) was significantly lower in ethanol treated animals on T1-weighted scans (P < .02). Precontrast, a significant difference in intensity was seen on T2-weighted scans (P < .01). Electron microscopy revealed severe hepatocyte damage. In the chronic groups, there was no significant difference in intensity precontrast. Postcontrast, enhancement (ethanol group) was significantly lower on T1-weighted scans only at 2 weeks (P < .05). Electron microscopy demonstrated progressive ethanol hepatotoxicity.
  
  
  CONCLUSIONS
  Magnetic resonance imaging can distinguish between normal and certain types of ethanol damaged livers on T1-weighted scans. Enhancement, however, does not correlate with progressive microscopic liver damage.
authors.affiliation: Department of Radiology, Stanford University School of Medicine, CA 94305-5105.
authors.forename: M K
authors.initials: MK
authors.lastname: Sidhu
authors.forename: H H
authors.initials: HH
authors.lastname: Muller
authors.forename: J
authors.initials: J
authors.lastname: Aggeler
authors.forename: A L
authors.initials: AL
authors.lastname: Jones
authors.forename: S W
authors.initials: SW
authors.lastname: Young
mesh_terms: D000818:Animals; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D000431:Ethanol / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008297:Male; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003287:Contrast Media; D000431:Ethanol; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid