title: Multicentre cross over study of aminoglutethimide and trilostane in advanced postmenopausal breast cancer.
abstract: Trilostane and Aminoglutethimide, each given with a physiological replacement dose of hydrocortisone, were randomly allocated to 72 eligible postmenopausal advanced breast cancer patients; following treatment failure on either drug the patient continued with the other drug, if in a suitable clinical condition. Thirty-eight patients initially received Trilostane of whom 19 subsequently received Aminoglutethimide; 34 patients initially had Aminoglutethimide and seven of these then received Trilostane. Both groups of patients were comparable in all respects. There was no difference in the objective response rate to either drug, Trilostane 11/38 = 29%, Aminoglutethimide 12/34 = 35%, nor in the average time to disease progression for the two drugs, Trilostane 64 weeks, Aminoglutethimide 68 weeks. Of the 26 patients who received both drugs, four showed a response to both suggesting no cross resistance. Side effects were seen to both drugs in approximately half of the patients, but were mainly gastro-intestinal with Trilostane and rash and drowsiness with Aminoglutethimide. There was no evidence of cross over patient susceptibility to side effects.
authors.affiliation: Royal South Hants Hospital, Southampton, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Williams
authors.forename: V L
authors.initials: VL
authors.lastname: Barley
authors.forename: G R
authors.initials: GR
authors.lastname: Blackledge
authors.forename: C G
authors.initials: CG
authors.lastname: Rowland
authors.forename: C J
authors.initials: CJ
authors.lastname: Tyrrell
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D000305:Adrenal Cortex Hormones / Q000037:antagonists & inhibitors; D000368:Aged; D000616:Aminoglutethimide / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D047072:Aromatase Inhibitors; D001943:Breast Neoplasms / Q000188:drug therapy*; D013196:Dihydrotestosterone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance; D004965:Estrogen Antagonists / Q000494:pharmacology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008190:Lyases / Q000037:antagonists & inhibitors; D008593:Menopause; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D004965:Estrogen Antagonists; D013196:Dihydrotestosterone; D000616:Aminoglutethimide; D015096:3-Hydroxysteroid Dehydrogenases; D008190:Lyases; C009954:trilostane; D006854:Hydrocortisone