Apnea and rapid eye movement sleep excess in the piglet during recovery from hyperthermia.
This investigation tested the hypothesis that artificially induced mild hyperthermia and recovery from hyperthermia in the developing newborn piglet (2-10 d of age) alter sleep state patterns and respiratory control. Continuous measurements of sleep state, respiratory pattern, carbon dioxide production and oxygen consumption were made before, during, and after a 3-h period of sustained hyperthermia. During hyperthermia, rectal temperatures were raised a mild 1-1.5 degree C above normal, well below the levels likely to cause severe physiologic distress in this species. This resulted in a disruption of the sleep state pattern characterized by a decrease in duration of rapid eye movement (REM) episodes, whereas immediately afterwards, during recovery, the amount of REM sleep increased. In some cases the amount of REM sleep in recovery more than doubled the basal level. Apneas were rarely observed during hyperthermia, but in recovery there was an increase in the total amount of time spent in apnea in both REM and non-rapid eye movement sleep states with a predominance in the REM state. Arousal responses to chemostimulation were not affected at this time. We conclude that the sleeping newborn piglet does indeed show marked changes in sleep state pattern (particularly REM sleep) and in the amount of apnea recorded during and immediately after only a mild increase in core temperature.
Galland
B C
BC
Department of Pediatrics and Child Health, University of Otago Medical School, Dunedin, New Zealand.
Bolton
D P
DP
Taylor
B J
BJ
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D004569:Electroencephalography; D004585:Electrooculography; D005260:Female; D005334:Fever / Q000503:physiopathology*; D006979:Hyperthermia, Induced; D008297:Male; D010101:Oxygen Consumption; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D012893:Sleep Wake Disorders / Q000209:etiology / Q000503:physiopathology*; D012895:Sleep, REM; D013552:Swine; D014851:Wakefulness