Overexpression of PRAD1 in a mantle zone lymphoma patient with a t(11;22)(q13;q11) translocation.
The PRAD1 gene identified from the chromosome band 11q13 region was previously demonstrated to be overexpressed in cell lines with t(11;14)(q13;q32) translocation and was suggested to be a candidate BCL-1 gene. We report here one case of mantle zone lymphoma with a t(11;22)(q13;q11), a variant translocation at the BCL-1 locus, having the PRAD1 overexpression. By analogy with the c-myc gene in Burkitt's lymphoma and the BCL-2 gene in follicular lymphoma, this case supports strongly the idea that the PRAD1 is the candidate BCL-1 gene.
Komatsu
H
H
Laboratory of Chemotherapy, Aichi Cancer Centre Research Institute, Nagoya, Japan.
Yoshida
K
K
Seto
M
M
Iida
S
S
Aikawa
T
T
Ueda
R
R
Mikuni
C
C
D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D019938:Cyclin D1; D016213:Cyclins / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
D016213:Cyclins; D015513:Oncogene Proteins; D019938:Cyclin D1