Evolutionary clustering and functional similarity of RNA-binding proteins.
RNA-binding proteins (RNPs) involved in splicing, processing and translation regulation contain one to four RNA-binding domains. We constructed a phylogenetic tree for the RNA-binding domains, including those of poly(A)-binding protein (PABP), splicing factors, chloroplast RNPs, hnRNPs, snRNP U1-70K, nucleolin and Drosophila sex determinants. Proteins with similar functions were found to have closely related RNA-binding domains and common domain organizations. In light of these observation, one can assume the function of an RNA-binding protein, based on the evolutionary relationship between its RNA-binding domain(s) and domain organization, as compared with other RNPs.
Fukami-Kobayashi
K
K
Department of Biology, Faculty of Science, Nagoya University, Japan.
Tomoda
S
S
Go
M
M
D000818:Animals; D005075:Biological Evolution; D002736:Chloroplasts / Q000378:metabolism; D017124:Conserved Sequence; D006801:Humans; D010802:Phylogeny; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism
D016601:RNA-Binding Proteins