title: The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma.
abstract: OBJECTIVE
  The purpose of this study was to determine if the presence or absence of tumor at the surgical margin in cases of impalpable breast carcinoma could be predicted accurately with specimen radiography.
  
  
  METHODS
  We obtained single-view radiographs of 119 consecutive surgical biopsy specimens of impalpable invasive or in situ ductal carcinoma. Radiographic lesions were classified as a mass with moderately well defined margins, a mass with poorly defined margins, or microcalcifications without an associated mass. The radiographic appearance of the impalpable cancer, the margin as judged from the specimen radiograph, the tumor's histologic appearance, and the histologic appearance of the tumor margin were then correlated.
  
  
  RESULTS
  Specimen radiographs showed tumor at the surgical margin in 63 cases; 62 of these were confirmed histologically (positive predictive value, 98%). Specimen radiographs showed tumor-free surgical margins in 56 cases; 18 of these were confirmed histologically (negative predictive value, 32%). These results were independent of the radiographic appearance of the lesion or the tumor's histologic appearance.
  
  
  CONCLUSIONS
  Decisions based on findings on specimen radiographs were valid only if the radiographs showed tumor at the margin of the specimen.
authors.affiliation: Department of Surgery, Tufts University School of Medicine, New England Medical Center Hospitals, Boston, MA 02111.
authors.forename: R A
authors.initials: RA
authors.lastname: Graham
authors.forename: M J
authors.initials: MJ
authors.lastname: Homer
authors.forename: C J
authors.initials: CJ
authors.lastname: Sigler
authors.forename: H
authors.initials: H
authors.lastname: Safaii
authors.forename: C H
authors.initials: CH
authors.lastname: Schmid
authors.forename: D J
authors.initials: DJ
authors.lastname: Marchant
authors.forename: T J
authors.initials: TJ
authors.lastname: Smith
mesh_terms: D001706:Biopsy; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008327:Mammography; D010173:Palpation; D012372:ROC Curve