title: Cytotoxic activity of [Pt(pyr)(N-Etlm)Cl4].
abstract: The [Pt(pyr)(N-Etlm)Cl4] complex, where pyr = pyrimidine and N-Etlm = N-ethylimidazole, previously prepared and characterized, showed an interesting cytotoxicity in vitro on the human ovarian carcinoma (A2780) and on his subline resistant to cis-platinum (A2780/CDDP), in comparison with cis-platinum and carboplatinum.
authors.affiliation: Dipartimento di Chimica e Tecnologie Inorganiche e Metallorganiche Università di Cagliari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Massacesi
authors.forename: Z
authors.initials: Z
authors.lastname: Matovic
authors.forename: G
authors.initials: G
authors.lastname: Ponticelli
mesh_terms: D000818:Animals; D016190:Carboplatin / Q000494:pharmacology; D002945:Cisplatin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D051379:Mice; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured
chemical_list: D009944:Organoplatinum Compounds; C084996:BBR 2889; D016190:Carboplatin; D002945:Cisplatin