Antibody-induced alterations of Na+/K(+)-ATPase activity in rabbit red blood cells during experimental thyroglobulin immunization.
Thyroid hormone modulates cell membrane Na+/K(+)-ATPase. A detailed study of erythrocyte membrane Na+/K(+)-ATPase activity was carried out during experimental thyroglobulin immunization. During the process of immunization there was a sharp decline in Na+/K(+)-ATPase activity until the 98th day of immunization, when the thyroglobulin antibody titer was at its peak. This enzyme activity retained a lower level although a fall in antibody titer occurred up to the 147th day.
Habibullah
C M
CM
Department of Gastroenterology, Osmania General Hospital, Hyderabad, India.
Swamy
M
M
Lahiri
S
S
D000818:Animals; D000906:Antibodies / Q000097:blood*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D007114:Immunization; D008297:Male; D011817:Rabbits / Q000276:immunology; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood* / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology* / Q000494:pharmacology
D000906:Antibodies; D013954:Thyroglobulin; D000254:Sodium-Potassium-Exchanging ATPase