title: Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza.
abstract: Bioassay-guided fractionation of a hexane extract of the rhizomes of Curcuma xanthorrhiza Roxb. (Zingiberaceae) led to the isolation of three non-phenolic diarylheptanoids, identified mainly by high-field 1H-NMR as trans-trans-1,7-diphenyl-1,3-heptadien-4-one (alnustone), trans-1,7-diphenyl-1-hepten-5-ol, and trans,trans-1,7-diphenyl-1,3-heptadien-5-ol. The latter is reported for the first time as a plant constituent. Germacrone, curzerenone, and cinnamaldehyde were also isolated and identified. The three diarylheptanoids all exerted significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Claeson
authors.forename: A
authors.initials: A
authors.lastname: Panthong
authors.forename: P
authors.initials: P
authors.lastname: Tuchinda
authors.forename: V
authors.initials: V
authors.lastname: Reutrakul
authors.forename: D
authors.initials: D
authors.lastname: Kanjanapothi
authors.forename: W C
authors.initials: WC
authors.lastname: Taylor
authors.forename: T
authors.initials: T
authors.lastname: Santisuk
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013729:Terpenes