Rheumatoid arthritis and B cell lymphoma with pathological changes of reactive histiocytosis.
A 67 year old woman with rheumatoid arthritis was admitted to hospital in acute renal failure. Her clinical features included increasing dyspnoea and oedema, and a computed tomogram of the abdomen showed a large mass in the retroperitoneum. Twenty six days later, she died, and a post mortem examination was carried out. The histological changes of the mass indicated B cell lymphoma of diffuse large cell type, with a reactive proliferation of erythrophagocytosing histiocytes. Immunocytochemical studies showed that the histiocytes were positive for CD-68 and lysozyme, but negative for S-100 protein. Such neoplastic B cell proliferation accompanied by activation of benign looking histiocytes with erythrophagocytosis is very rare.
Shimada
M
M
Department of Internal Medicine, Ashikaga Red Cross Hospital, Tochigi, Japan.
Kojima
M
M
Tani
G
G
Komatsumoto
S
S
Nara
M
M
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D015614:Histiocytosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000473:pathology