Morphological changes in the hearts of CD1 mice following chronic treatment with doxorubicin and lonidamine.
CD1 female mice were treated with doxorubicin (DXR, 5 mg/Kg i.v.) once a week for eight weeks or with lonidamine (LND, 100 mg/Kg i.p.) once a week for eight weeks. Other mice received lonidamine (100 mg/Kg i.p.) immediately before doxorubicin (5 mg/Kg i.v.) administration. The animals were sacrificed four weeks after the last administration and their cardiac morphology was evaluated by means of light microscopy. Lonidamine slightly reduced the extent of the atrial but not of the ventricular alterations caused by DXR. The results seem to indicate that, in this experimental model, lonidamine does not substantially modify the cardiotoxicity induced by doxorubicin.
Sanguedolce
R
R
Istituto di Farmacologia, Policlinico P. Giaccone, Palermo, Italy.
Flandina
C
C
Cucchiara
T
T
Varvara
F
F
Rausa
L
L
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects; D006346:Heart Septum / Q000187:drug effects / Q000473:pathology; D006352:Heart Ventricles / Q000187:drug effects / Q000473:pathology; D007191:Indazoles / Q000494:pharmacology; D051379:Mice; D009206:Myocardium / Q000473:pathology*
D000970:Antineoplastic Agents; D007191:Indazoles; D004317:Doxorubicin; C016371:lonidamine