[Oxidative phosphorylation uncoupling by fatty acids in liver and muscle mitochondria].
Pathways and mechanisms of oxidative phosphorylation uncoupling by long-chain fatty acids in liver and muscle mitochondria are considered. A conclusion is drawn that there exist at least three different pathways of uncoupling by fatty acids, namely: (i) a Ca(2+)-dependent cyclosporin A-sensitive pathway; (ii) uncoupling which is inhibited by carboxyatractylate or other inhibitors of the ADP/ATP-antiporter, (iii) uncoupling due to the low protonophoric activity of fatty acids.
Mokhova
E N
EN
Istituto di Patologia Generale, Universita degli Study di Modena, Italy.
Starkov
A A
AA
Bobyleva
V A
VA
D000818:Animals; D005227:Fatty Acids / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010743:Phospholipids / Q000378:metabolism; D014475:Uncoupling Agents / Q000494:pharmacology*
D005227:Fatty Acids; D010743:Phospholipids; D014475:Uncoupling Agents; D000226:Mitochondrial ADP, ATP Translocases
Razobshchenie okislitel'nogo fosforilirovaniia zhirnymi kislotami v mitokhondriiakh pecheni i myshts.