title: A clinically oriented approach to smooth pursuit eye movement quantitative evaluation.
abstract: The electrooculographic technique was used to record smooth pursuit eye movements in 71 healthy subjects homogeneously distributed within an age range between the 2nd and the 6th decades. The target moved at constant velocity (triangular ramps) and 9 different target velocities (V), from 10 deg/s to 50 deg/s were considered and presented according to pseudorandom sequence. Ad hoc software suppressed catch-up saccades so that a pursuit index (PI) value was computed for each ramp taking into account only the smooth pursuit tracking modality. It was demonstrated that the relationship between V and PI could be described by the linear model PI = a + b * V. Pursuit index was proved to be influenced by the age of subject (decade factor in the analysis of variance), since an almost linear increase in b values yields a reduction of pursuit index values. The method was tested in 22 multiple sclerosis patients and an association was found between the occurrence of cerebellar signs and the reduction of a value.
authors.affiliation: Neurological Institute C. Mondino, University of Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Versino
authors.forename: G
authors.initials: G
authors.lastname: Beltrami
authors.forename: D
authors.initials: D
authors.lastname: Zambarbieri
authors.forename: G
authors.initials: G
authors.lastname: Castelnovo
authors.forename: R
authors.initials: R
authors.lastname: Bergamaschi
authors.forename: A
authors.initials: A
authors.lastname: Romani
authors.forename: V
authors.initials: V
authors.lastname: Cosi
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D015415:Biomarkers; D002526:Cerebellar Diseases / Q000175:diagnosis; D002648:Child; D004585:Electrooculography / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009103:Multiple Sclerosis / Q000175:diagnosis; D011698:Pursuit, Smooth / Q000502:physiology*; D012044:Regression Analysis; D012438:Saccades / Q000502:physiology
chemical_list: D015415:Biomarkers