Pharmacodynamic interpretation of adrenocorticotropin stimulation tests.
OBJECTIVE
To report a pharmacodynamic model that describes increases in cortisol concentrations during administration of an adrenocorticotropin (ACTH) infusion, taking into account both steroid secretion and elimination.


METHODS
Previously published data.


RESULTS
Using a population estimate of the elimination rate constant for cortisol and equations describing changes in cortisol concentration versus time, a value for the rate of cortisol secretion (Rcort) was derived. The Rcort value more directly represents the capacity for adrenal secretion of cortisol.


CONCLUSIONS
Pharmacodynamic modeling techniques were used to successfully describe the rate of cortisol secretion during an ACTH infusion. This model can be applied to assess the extent of adrenal suppression after long-term corticosteroid therapy or in the presence of disease states.
Milad
M A
MA
State University of New York at Buffalo 14260.
Jusko
W J
WJ
D000311:Adrenal Glands / Q000378:metabolism; D000324:Adrenocorticotropic Hormone; D006207:Half-Life; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D007262:Infusions, Intravenous; D008657:Metabolic Clearance Rate; D008954:Models, Biological
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone