title: Consumption coagulopathy associated with shock in acute African swine fever.
abstract: We studied the evolution of shock using a comprehensive array of haematological tests in pigs infected with the highly virulent strain Malawi '83 (Lilongwe 20/1). A sudden onset of illness was observed between day 5 and 7 after inoculation with development of flush, episodes of epistaxis and melaena. Prior to these clinical signs, initiation of a consumption coagulopathy was demonstrated with loss of antithrombin III and plasminogen activity. Our findings indicate that during infection with this highly virulent strain the development of a consumption coagulopathy precedes and possibly contributes to shock, which results in haemorrhage and death.
authors.affiliation: Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
authors.forename: C J
authors.initials: CJ
authors.lastname: Villeda
authors.forename: S M
authors.initials: SM
authors.lastname: Williams
authors.forename: P J
authors.initials: PJ
authors.lastname: Wilkinson
authors.forename: E
authors.initials: E
authors.lastname: Viñuela
mesh_terms: D000208:Acute Disease; D000357:African Swine Fever / Q000097:blood / Q000150:complications*; D000818:Animals; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D010976:Platelet Count; D012769:Shock / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology*
chemical_list: D001779:Blood Coagulation Factors