title: Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia. Lack of influence of symptom subgroups and H. pylori-associated gastritis.
abstract: The relative contributions of altered gastric motor function and Helicobacter pylori-associated active chronic gastritis to the pathogenesis of functional dyspepsia are controversial. We therefore evaluated scintigraphically the intragastric distribution and gastric emptying of a mixed solid-liquid meal in 75 patients with functional dyspepsia; patients were subdivided on the basis of both specific symptom clusters and the presence or absence of H. pylori gastritis. Twenty-one (28%) patients displayed abnormal solid and/or liquid gastric emptying, with prolonged solid lag time the most prominent alteration detected. The number of patients with abnormal scintigraphic patterns increased to 36 (48%) when intragastric distribution parameters (fundal half-emptying time and antral maximal fraction) were examined. Although patients with reflux-like dyspepsia (N = 36) demonstrated significantly slower rates of liquid emptying at 45 and 70 min and a higher prevalence of abnormal liquid intragastric distribution when compared to patients with motility-like dyspepsia (N = 39) or to controls (N = 34), the absolute differences were small and unlikely to be of clinical significance. Patients without H. pylori gastritis (N = 50) demonstrated a significantly more prolonged solid lag time when compared to those with H. pylori gastritis (N = 25), but the difference was small and there were no other differences between these two subgroups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia.
authors.forename: A M
authors.initials: AM
authors.lastname: Scott
authors.forename: J E
authors.initials: JE
authors.lastname: Kellow
authors.forename: B
authors.initials: B
authors.lastname: Shuter
authors.forename: H
authors.initials: H
authors.lastname: Cowan
authors.forename: A M
authors.initials: AM
authors.lastname: Corbett
authors.forename: J W
authors.initials: JW
authors.lastname: Riley
authors.forename: M R
authors.initials: MR
authors.lastname: Lunzer
authors.forename: R P
authors.initials: RP
authors.lastname: Eckstein
authors.forename: R
authors.initials: R
authors.lastname: Höschl
authors.forename: S K
authors.initials: SK
authors.lastname: Lam
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004415:Dyspepsia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000502:physiology*; D005756:Gastritis / Q000382:microbiology / Q000503:physiopathology*; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012737:Sex Factors