title: Schistosoma mansoni: fatty acid-induced cercarial tail loss does not involve eicosanoid production and chemoreceptors.
abstract: Inhibitors of eicosanoid production had no effect on linoleic acid-induced Schistosoma mansoni cercarial tail loss. In addition, linoleic acid-induced cercarial tail loss was not inhibited by silver nitrate, which binds to putative chemoreceptors for fatty acids in cercariae. There was no correlation between molecular structures of fatty acids and their potencies to induce tail loss. Furthermore, transcompounds of fatty acids which cannot be precursors of eicosanoids elicited tail loss as potently as cis-compounds did. The present results suggest that fatty acid-induced cercarial tail loss is not mediated by eicosanoid production and chemoreceptors, which are involved in cercarial penetration behavior stimulated by fatty acids.
authors.affiliation: Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford 61107.
authors.forename: I
authors.initials: I
authors.lastname: Hara
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: B
authors.initials: B
authors.lastname: Salafsky
authors.forename: T
authors.initials: T
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D002628:Chemoreceptor Cells / Q000378:metabolism*; D015777:Eicosanoids / Q000096:biosynthesis*; D005227:Fatty Acids / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D012835:Silver Nitrate / Q000494:pharmacology; D013623:Tail
chemical_list: D015777:Eicosanoids; D005227:Fatty Acids; D012835:Silver Nitrate