title: Isolated vitamin E deficiency and progressive ataxia.
abstract: A case of progressive spinocerebellar syndrome due to isolated vitamin E deficiency is reported. Measurement of the vitamin E concentration in serum should be included when investigating all children with unexplained, progressive ataxia, even in the absence of malabsorption. Replacement treatment in patients with a vitamin E deficiency can arrest or improve the associated neurological disorder.
authors.affiliation: Regional Child Development Centre, St James's University Hospital, Leeds.
authors.forename: R J
authors.initials: RJ
authors.lastname: Rayner
authors.forename: R
authors.initials: R
authors.lastname: Doran
authors.forename: S H
authors.initials: SH
authors.lastname: Roussounis
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D012164:Retinal Diseases / Q000188:drug therapy / Q000209:etiology; D013132:Spinocerebellar Degenerations / Q000188:drug therapy / Q000209:etiology*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000150:complications* / Q000188:drug therapy; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols