title: Pulmonary chemoreflex and phrenic sympathetic efferents.
abstract: The pulmonary chemoreflex components such as reactions of phrenic sympathetic neuron (PhSN) activity, phrenic nerve activity, heart rate and blood pressure were tested in chloralose-anesthetized, paralyzed cats. 10 micrograms to 160 micrograms phenylbiguanide (PBG) in 0.9% NaCl was injected into the pulmonary circulation. PBG injected into the right atrium (in 11 of 19 experiments) and into the pulmonary artery (in 5 of 8 experiments), evoked short-latency (1-1.4 sec) dose-dependent increase in PhSN activity accompanied by increase in blood pressure, and followed by decrease in these two variables. In all experiments, activity of the phrenic nerve was depressed, and bradycardia occurred after PBG injection. All responses to PBG injections into the pulmonary artery were abolished following bilateral vagotomy. In the same procedure related to the right atrium after vagotomy, the increases in PhSN activity and blood pressure were also abolished, although a decrease in heart rate, PhSN activity and in the amplitude of phrenic nerve discharges together with an increase in their frequency persisted. Our results suggest that short-latency increase in PhSN activity is a component of pulmonary chemoreflex.
authors.affiliation: Department of Physiology, Faculty of Medicine, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Bałkowiec
authors.forename: P
authors.initials: P
authors.lastname: Szulczyk
mesh_terms: D000818:Animals; D001645:Biguanides / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002628:Chemoreceptor Cells / Q000502:physiology*; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D007267:Injections; D008168:Lung / Q000294:innervation*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
chemical_list: D001645:Biguanides; C008846:phenyl biguanide