Reduced inhibition of endothelial-derived relaxing factor causes the hyperdynamic circulation in chronic severe anemia.
Patients with chronic severe anemia have a vasodilated state and hyperdynamic circulation. The cause of vasodilation in these patients is not known. We postulate that the low levels of hemoglobin in these patients results in reduced inhibition of basal EDRF activity leading to generalized vasodilation.
Anand
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IS
Division of Cardiovascular Medicine, University of Minnesota School of Medicine, VA Medical Center IIIC, Minneapolis 55417.
Chandrashekhar
Y
Y
D000740:Anemia / Q000503:physiopathology*; D002908:Chronic Disease; D006439:Hemodynamics / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008955:Models, Cardiovascular; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000502:physiology; D012079:Renal Circulation / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D006454:Hemoglobins; D009569:Nitric Oxide