title: Pyrrolo[1',2':1,2]imidazo[4,5-b]pyridines, pyrrolo- [2',1':2,3]imidazo[4,5-c]pyridines and pyrrolo[2,1-f]purines as potential benzodiazepine ligands.
abstract: The synthesis of some 7,8,8a,9-tetrahydro-6H-pyrrolo[1',2':1,2]imidazo[4,5-b]pyridin-6-ones, 5,5a,6,7-tetrahydro-8H-pyrrolo[2',1':2,3]imidazo[4,5-c]pyridin-8-ones and 7,8,8a,9-tetrahydro-6H-pyrrolo[2,1-f]purin-6-ones is reported. The structure of the obtained compounds has been assigned by means of 1H-NMR spectra assisted by NOESY measurements. In addition, the ability to displace [3H]-flunitrazepam binding from rat brain membranes is determined. Only the pyrrolopurine derivative 5d binds to the benzodiazepine receptor (BZR) with appreciable potency.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina.
authors.forename: A
authors.initials: A
authors.lastname: Chimirri
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: P
authors.initials: P
authors.lastname: Monforte
authors.forename: M
authors.initials: M
authors.lastname: Zappalà
authors.forename: G
authors.initials: G
authors.lastname: Genchi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism*
chemical_list: D011687:Purines; D011725:Pyridines; D011758:Pyrroles; D011963:Receptors, GABA-A; D005445:Flunitrazepam