title: Feasibility of curative radiotherapy with a concomitant boost technique in 33 patients with non-small cell lung cancer (NSCLC)
abstract: Thirty-three patients with an inoperable NSCLC were treated with a dose of 60 Gy/20 fractions/25 days, using a concomitant boost technique. A dose of 40 Gy/2 Gy/25 days was given to the tumor area and a part (15 patients) or the whole (18 patients) mediastinum. During each session a simultaneous boost to the tumor of 1 Gy was administered. Moderate acute oesophageal toxicity was observed in 7/33 patients (22%). One out of 33 patients developed serious late oesophageal toxicity. A correlation between the oesophageal toxicity, absorbed oesophageal dose of irradiation and length of the elective field was observed. Five out of 33 patients developed subacute radiation pneumonitis grade 2 or 3. In selected patients with inoperable NSCLC radiotherapy, with a dose of 60 Gy/20 fractions/25 days, using a concomitant technique is feasible.
authors.affiliation: Department of Radiotherapy, University of Amsterdam, Academisch Medisch Centrum, The Netherlands.
authors.forename: A L
authors.initials: AL
authors.lastname: Schuster-Uitterhoeve
authors.forename: M C
authors.initials: MC
authors.lastname: Hulshof
authors.forename: D
authors.initials: D
authors.lastname: Gonzàlez Gonzàlez
authors.forename: M
authors.initials: M
authors.lastname: Koolen
authors.forename: P
authors.initials: P
authors.lastname: Sminia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D004947:Esophagus / Q000528:radiation effects; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000473:pathology; D017564:Radiation Pneumonitis / Q000473:pathology; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects