[The smooth-muscle adenylate cyclase system of invertebrate and vertebrate animals as the target of glucagon action].
Stimulatory effect, as well as potentiation of the latter by guanine nucleotides, of mammalian glucagon on adenylate cyclase system from plain muscles of bivalve, gastropod molluscs, holothurians and ascidians have been revealed. The same effects were found in tissues of vertebrate animals (human myometrium, aorta and liver of rats, stomach and liver of chicks). These data indicate effective coupling of all the components of glucagon-sensitive adenylate cyclase system in plain muscles of all the investigated animals.
Kuznetsova
L A
LA
Plesneva
S A
SA
Pertseva
M N
MN
D000262:Adenylyl Cyclases / Q000187:drug effects*; D000818:Animals; D002645:Chickens; D004357:Drug Synergism; D004447:Echinodermata; D005934:Glucagon / Q000494:pharmacology*; D006150:Guanine Nucleotides / Q000494:pharmacology; D006801:Humans; D007448:Invertebrates / Q000187:drug effects* / Q000201:enzymology; D008195:Lymnaea; D008974:Mollusca; D009130:Muscle, Smooth / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013268:Stimulation, Chemical; D014714:Vertebrates / Q000378:metabolism*
D006150:Guanine Nucleotides; D005934:Glucagon; D000262:Adenylyl Cyclases
Adenilattsiklaznaia sistema gladkikh myshts bespozvonochnykh i pozvonochnykh zhivotnykh kak mishen' deĭstviia gliukagona.