Interleukin-7, a major T-lymphocyte cytokine.
IL-7 is a single-chain 25 kDa protein first identified in bone marrow cultures through its pre-B cell growth factor properties, then also described as a potent T-lymphocyte growth factor. This review relates to the molecular and functional aspects of interleukin-7 (IL-7) and its receptor (IL-7R). We focused on the role of IL-7 in T-cell activation, cytotoxicity generation, leukemic cell growth and immunotherapy.
Costello
R
R
Unite INSERM U119, Marseille, France.
Imbert
J
J
Olive
D
D
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D003602:Cytotoxicity, Immunologic / Q000502:physiology; D005796:Genes; D006084:Graft Rejection; D006801:Humans; D015851:Interleukin-7 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D007938:Leukemia / Q000473:pathology; D008213:Lymphocyte Activation / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000187:drug effects; D018123:Receptors, Interleukin / Q000235:genetics / Q000502:physiology; D020395:Receptors, Interleukin-7; D011994:Recombinant Proteins / Q000096:biosynthesis; D017385:Sequence Homology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000637:transplantation
D015851:Interleukin-7; D018123:Receptors, Interleukin; D020395:Receptors, Interleukin-7; D011994:Recombinant Proteins