[The effect of low dose aspirin on the platelet function in patients with acute myocardial infarction].
To assess the appropriate dose of aspirin in the treatment of patients with acute myocardial infarction (AMI), 60 cases of AMI were randomized into 2 groups, 30 cases each; one with conventional therapy, another with conventional therapy combined with daily oral aspirin 100mg. The second group was further divided into subgroup I with serum peak CK < 1000 U/L and subgroup II with serum peak CK > 1000U/L. The parameters of platelet function including plasma TXB2, TXB2/6-keto-PGF1 alpha, platelet aggregation induced by 5-HT and epinephrine were studied on different days for 3 weeks. The results revealed that there was a successful inhibition of platelet function as assessed by significant decrease of plasma TXB2 and TXB2/6-keto-PGF1 alpha ratio and inhibition of platelet aggregation in the subgroup I, but little effect on subgroup II. It is shown that in the treatment of AMI, a daily dose of 100mg of aspirin is insufficient for severe cases, and according to the observation in ISIS-2 study, a daily dose of aspirin around 160mg may be appropriate.
Jin
L
L
Peking Union Medical College Hospital, Beijing.
Xu
S H
SH
Yan
X W
XW
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D010979:Platelet Function Tests; D013929:Thromboxane B2 / Q000097:blood
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D001241:Aspirin