title: The structure of the human thyroxine binding globulin (TBG) gene.
abstract: A portion of the human X-chromosome (> 5 kb) encoding the translated portion of the thyroxine-binding globulin (TBG) gene was sequenced. The primary templates for sequencing were isolated from a human X-chromosome library (two positive plaques from 400,000 screened initially with a TBG cDNA probe) or were produced by PCR amplification using leucocyte genomic DNA as the amplification template. Potential hormone response elements (HREs) were identified at either end of the gene. These HREs have sequences based on the consensus half-site of thyroid hormone response elements, although it is unclear whether the structures are functional HREs. Other potential regulatory elements also were identified towards the 3' end of the gene.
authors.affiliation: Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK.
authors.forename: M T
authors.initials: MT
authors.lastname: Akbari
authors.forename: A
authors.initials: A
authors.lastname: Kapadi
authors.forename: M J
authors.initials: MJ
authors.lastname: Farmer
authors.forename: N J
authors.initials: NJ
authors.lastname: Fitch
authors.forename: K P
authors.initials: KP
authors.lastname: McCann
authors.forename: S
authors.initials: S
authors.lastname: Kordestani
authors.forename: I L
authors.initials: IL
authors.lastname: Flink
authors.forename: M C
authors.initials: MC
authors.lastname: Sheppard
authors.forename: D B
authors.initials: DB
authors.lastname: Ramsden
mesh_terms: D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D015342:DNA Probes; D005091:Exons; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense; D016133:Polymerase Chain Reaction; D014176:Protein Biosynthesis; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013698:Templates, Genetic; D013975:Thyroxine-Binding Proteins / Q000235:genetics*; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D016376:Oligonucleotides, Antisense; D013975:Thyroxine-Binding Proteins