Tylophora compounds as Na+/K(+)-ATPase inhibitors.
1. Acetyltylophoroside (AcT) and tylogenin inhibit Na+/K(+)-ATPase in spite of having structures very different from cardiac glycosides (CGs). 2. Calculation of the lowest energy conformations of AcT and tylogenin and superpositions of these with the X-ray conformations of CGs and chlormadinone acetate led to a model for the interaction of these different types of Na+/K(+)-ATPase inhibitors with the receptor.
Gnabre
J N
JN
Health Sciences Center, University of Arizona, Tucson, AZ 85724.
Pinnas
J L
JL
Bates
R B
RB
Dolata
D P
DP
Gangwar
S
S
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001485:Basement Membrane / Q000187:drug effects / Q000201:enzymology; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000201:enzymology; D008958:Models, Molecular; D008968:Molecular Conformation; D010042:Ouabain / Q000031:analogs & derivatives / Q000494:pharmacology; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D011817:Rabbits; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013256:Steroids
D010616:Phenanthrenes; D012503:Saponins; D013256:Steroids; C085024:tylogenin; C085023:acetyltylophoroside; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D015107:4-Butyrolactone; C008721:ouabagenin