[Evaluation in mice of the efficacy of antivenins administered at the site of the intramuscular inoculation of the Crotalus durissus terrificus venom].
The efficacy of the Crotalus durissus terrificus antivenom administration by intramuscular (im) injection at the same place of the im inoculation, of the C. d. terrificus venom was evaluated in mice. In three experiments two DL50 of the venom were inoculated and the antivenom was administered in three different ways: half of the ED50 by intraperitoneal (ip) administration and half by injection, at the same place, immediately after the venom inoculation and thirty minutes after the im venom inoculation; four fifth of ED50 by ip administration and one fifth by injection, at the same place and thirty minutes after the venom inoculation. The antivenom that was administered by intraperitoneal route provided a higher protection to mice (a lower death rate in a 48 hours period) than when it was administered in parts, by intramuscular injection, at the same place of the venom inoculation (p < 0.05). Therefore, it is concluded that this should not be used in human beings bitten by snakes.
Ribeiro
L A
LA
Hospital Vital Brazil do Instituto Butantan, São Paulo, Brasil.
Utescher
C L
CL
Vieira
S L
SL
Fensterseifer
S
S
Mukuno
H
H
Jorge
M T
MT
D000818:Animals; D000997:Antivenins / Q000008:administration & dosage* / Q000494:pharmacology; D003435:Crotalid Venoms / Q000008:administration & dosage / Q000506:poisoning*; D005260:Female; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice
D000997:Antivenins; D003435:Crotalid Venoms
Avaliação em camundongo da eficácia do antiveneno administrado no local da inoculação intramuscular do veneno de Crotalus durissus terrificus.