title: Repeated hepatic ischemia in combination with chemotherapy for liver carcinoid metastases.
abstract: Both hepatic ischemia and chemotherapy are effective in the treatment of carcinoid liver metastases, but their effectiveness is often limited, partial and transient. It has been shown that, during intermittent occlusion of the hepatic artery with a surgically implanted occluder, no revascularisation from collaterals occurs. We studied the feasibility, the side-effects, the response to tumour measurements and hormonal excretions of a combined treatment of repeated hepatic ischemia and 5-Fluorouracil and Streptozotocin-administration in carcinoid liver metastases.
authors.affiliation: Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Van Cutsem
authors.forename: F
authors.initials: F
authors.lastname: Penninckx
authors.forename: L
authors.initials: L
authors.lastname: Filez
authors.forename: R
authors.initials: R
authors.lastname: Kerremans
authors.forename: G
authors.initials: G
authors.lastname: Vantrappen
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002276:Carcinoid Tumor / Q000556:secondary / Q000628:therapy*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D013311:Streptozocin / Q000008:administration & dosage
chemical_list: D013311:Streptozocin; D005472:Fluorouracil