title: Diagnosis of prostatic carcinoma: value of random transrectal sonographically guided biopsies.
abstract: OBJECTIVE
  We studied the efficacy of random, transrectal sonographically guided biopsies in the diagnosis of prostatic carcinoma in a high-risk population.
  
  
  METHODS
  During a 2-year period, 570 transrectal sonographically guided prostatic biopsies were done because of clinical findings suggestive of prostatic carcinoma. Biopsies of hypoechoic lesions that were suggestive of carcinoma and segmental random biopsies of normal-appearing lobes of the prostate were performed. Transrectal sonographic findings were correlated with results of pathologic examination of the biopsy specimen and with surgical results, when available.
  
  
  RESULTS
  Of the 202 patients found to have carcinoma, the carcinoma was detected with directed biopsy in 145 patients (72%). One hundred twenty (71%) of 169 carcinomas were detected with random biopsy when that procedure was performed. Random biopsies were the only method of diagnosing 57 (28%) of the 202 carcinomas, increasing the yield by 39%.
  
  
  CONCLUSIONS
  Yield of carcinoma on transrectal sonographically guided biopsies increases significantly when segmental random biopsies are performed. Transrectal sonographically guided biopsies should include cores through hypoechoic lesions that are suggestive of carcinoma and bilateral segmental random biopsies.
authors.affiliation: Department of Diagnostic Radiology, Lahey Clinic, Burlington, MA 01805.
authors.forename: S M
authors.initials: SM
authors.lastname: Slonim
authors.forename: J T
authors.initials: JT
authors.lastname: Cuttino
authors.forename: C J
authors.initials: CJ
authors.lastname: Johnson
authors.forename: B C
authors.initials: BC
authors.lastname: Yankaskas
authors.forename: J J
authors.initials: JJ
authors.lastname: Smith
authors.forename: M L
authors.initials: ML
authors.lastname: Silverman
authors.forename: J A
authors.initials: JA
authors.lastname: Libertino
mesh_terms: D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018084:Ultrasonography, Interventional