title: Malignant mixed exocrine-endocrine tumor of the pancreas with unusual intracytoplasmic inclusions.
abstract: A case of malignant mixed exocrine-endocrine tumor of the pancreas is reported. Electron microscopy revealed abundant neurosecretory granules in most cels. Zymogen granules indicating acinar differentiation were seen in a few cells. Ductal features, including microvilli with prominent filamentous cores and intracytoplasmic mucin granules, were also noted in this lesion. immunocytochemical strains were positive for serotonin and glucagon. Unusual intracytoplasmic fibrillary inclusions are described and their possible origin discussed.
authors.affiliation: Electron Microscopy Program, Veterans Affairs Medical Center, Cleveland, Ohio.
authors.forename: M O
authors.initials: MO
authors.lastname: Hassan
authors.forename: P A
authors.initials: PA
authors.lastname: Gogate
mesh_terms: D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004702:Endocrine Glands / Q000648:ultrastructure; D004792:Enzyme Precursors / Q000032:analysis; D005088:Exocrine Glands / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000648:ultrastructure*
chemical_list: D004792:Enzyme Precursors