Cholesterol absorption and excretion in ileostomy subjects on high- and low-dietary-cholesterol intakes.
Six healthy ileostomy subjects were given [3H]cholesterol and [14C]beta-sitosterol in a single meal together with two controlled diets containing 150 or 450 mg cholesterol/d. Each diet was eaten for 3 d. Cholesterol absorption and excretion of cholesterol, bile acids, fat, energy, and nitrogen were analyzed. Fractional cholesterol absorption increased from 44 +/- 2.6% (mean +/- SE) to 61 +/- 3.4% (P < 0.05), but absolute cholesterol absorption decreased from 191 +/- 11 to 94 +/- 9 mg/d (P < 0.05) on low cholesterol intake compared with high cholesterol intake. Weight of ileostomy effluent, or excretion of energy, nitrogen, fat, and bile acids did not differ between periods. Endogenous cholesterol excretion remained unchanged whereas net cholesterol excretion (output minus intake) was 37% higher (P < 0.05) on low compared with high cholesterol intake.
Ellegård
L
L
Department of Clinical Nutrition, University of Göteborg, Sahlgrenska Hospital, Sweden.
Bosaeus
I
I
D000328:Adult; D000368:Aged; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007081:Ileostomy; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002791:Cholesterol, Dietary