Iron: metabolism, toxicity and therapy.
This paper is an overview on iron metabolism, iron toxicity and therapeutics against this toxicity. The attention has been focused on: i) the solubilization of iron by living organisms; ii) the iron metabolism in human; iii) the toxicity of iron (Fe-catalyzed reduction of oxygen, Fenton reaction, decomposition of lipid peroxides); iv) the natural protective mechanisms; v) the relations between iron, free radicals and human diseases; and vi) the iron overload and its treatment.
Fontecave
M
M
LEDSS, URA-CNRS DO332, Université Joseph Fourier, Grenoble, France.
Pierre
J L
JL
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002614:Chelating Agents / Q000627:therapeutic use; D016166:Free Radical Scavengers; D005609:Free Radicals; D006801:Humans; D007501:Iron / Q000378:metabolism* / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D010084:Oxidation-Reduction; D012995:Solubility
D000975:Antioxidants; D002614:Chelating Agents; D016166:Free Radical Scavengers; D005609:Free Radicals; D007501:Iron