title: Transcription and DNA supercoiling.
abstract: Transcription and supercoiling of the DNA template are interrelated. This review summarizes recent progress in the study of how template topology affects transcription, and how transcription affects template topology inside wild-type and DNA topoisomerase mutant cells. The interplay between DNA supercoiling and transcription raises interesting questions on the regulation of adjacent genes, the organization of intracellular DNA, and the coupling between transcription and other cellular processes involving DNA.
authors.affiliation: Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
authors.forename: J C
authors.initials: JC
authors.lastname: Wang
authors.forename: A S
authors.initials: AS
authors.lastname: Lynch
mesh_terms: D000818:Animals; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D004278:DNA, Superhelical; D006801:Humans; D014158:Transcription, Genetic
chemical_list: D004278:DNA, Superhelical; D004264:DNA Topoisomerases, Type I