title: Application of fluorescent in situ hybridization for 'de novo' anomalies in prenatal diagnosis.
abstract: Fluorescent in situ Hybridization (FISH) was carried out for three cases of abnormal karyotypes in prenatal studies. Two concerned de novo structural anomalies and the third a marker chromosome. The origin of the extra material could be defined in all three cases, which gives a better insight into the relationship between genotype and phenotype and makes more adequate genetic counselling possible.
authors.affiliation: Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Van Opstal
authors.forename: H J
authors.initials: HJ
authors.lastname: Eussen
authors.forename: J O
authors.initials: JO
authors.lastname: Van Hemel
authors.forename: E S
authors.initials: ES
authors.lastname: Sachs
mesh_terms: D000328:Adult; D000649:Amniocentesis; D002869:Chromosome Aberrations / Q000175:diagnosis* / Q000235:genetics; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002887:Chromosomes, Human, Pair 18; D015342:DNA Probes; D003616:Dandy-Walker Syndrome / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D007231:Infant, Newborn; D007621:Karyotyping; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000379:methods*; D014178:Translocation, Genetic; D014314:Trisomy
chemical_list: D015342:DNA Probes