title: [Concentrations of propofol in maternal and fetal blood during anesthesia for cesarean section].
abstract: The authors studied, until the delivery, the pharmacokinetics of propofol during cesarean section. Ten patients were studied. Anaesthesia was induced and maintained with propofol (2 mg/kg in 15 seconds; 3 mg/kg/h until the end of the operation). All the patients have been intubated after the administration of atracurium 0.4 mg/kg and artificially ventilated with O2/N2O (FiO2 0.4). A series of maternal blood samples was obtained. Umbilical artery and venous blood samples have been obtained at delivery. Propofol levels in whole blood samples have been measured by a HPLC method (High pressure liquid chromatography). The results were: at delivery the mean ratio of the drug concentration in the umbilical vein to that in maternal vein was 0.53 +/- 0.16 micrograms/ml; the mean concentration in the umbilical vein was 0.96 +/- 0.31 micrograms/ml. The anaesthesiological protocol was clinically satisfactory and had no adverse effects on mother and foetus.
authors.affiliation: Istituto di Anestesiologia e Rianimazione, Università degli Studi di Catania.
authors.forename: G B
authors.initials: GB
authors.lastname: Audibert
authors.forename: G
authors.initials: G
authors.lastname: Bulla
authors.forename: G
authors.initials: G
authors.lastname: Di Bono
authors.forename: G
authors.initials: G
authors.lastname: Palazzo
authors.forename: G
authors.initials: G
authors.lastname: Romano
authors.forename: G
authors.initials: G
authors.lastname: Vaccaro
authors.forename: A
authors.initials: A
authors.lastname: Zagami
mesh_terms: D000293:Adolescent; D000328:Adult; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D015742:Propofol / Q000097:blood*
chemical_list: D015742:Propofol
vernacular_title: Concentrazioni di propofol nel sangue materno e fetale in corso di anestesia per taglio cesareo.