title: Effect of zinc treatment on serum thyroid hormones in uremic patients under peritoneal dialysis.
abstract: In order to evaluate the effect of zinc (Zn) deficiency on thyroid abnormalities in chronic renal failure, a Zn supplement (100 mg/day, p.o.) was given for four weeks to eight uremic patients under peritoneal dialysis. Zn supplementation increased plasma levels of TSH (5.8 +/- 0.7 to 7.4 +/- 0.7 mU/l, p < 0.02), T4 (61.6 +/- 3.9 to 93.9 +/- 6.2 nmol/l, p < 0.01), T3 (1.31 +/- 0.14 to 1.70 +/- 0.18 nmol/l, p < 0.01) and Zn (7.23 +/- 0.45 to 12.27 +/- 0.76 mumol/l, p < 0.01). A close correlation was found between changes in plasma levels of Zn and changes in TSH (r = 0.82), T4 (r = 0.55) and T3 (r = 0.64), suggesting that Zn deficiency may play a role in the biosynthesis or release of hormones of the hypothalamic-pituitary-thyroid axis in chronic renal failure.
authors.affiliation: Hospital de Pediatría, Instituto Mexicano del Seguro Social, México, D.F., México.
authors.forename: F
authors.initials: F
authors.lastname: Arreola
authors.forename: R
authors.initials: R
authors.lastname: Paniagua
authors.forename: A
authors.initials: A
authors.lastname: Pérez
authors.forename: S
authors.initials: S
authors.lastname: Díaz-Bensussen
authors.forename: E
authors.initials: E
authors.lastname: Junco
authors.forename: S
authors.initials: S
authors.lastname: Villalpando
authors.forename: E
authors.initials: E
authors.lastname: Exaire
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood; D014511:Uremia / Q000097:blood / Q000150:complications / Q000628:therapy*; D015032:Zinc / Q000172:deficiency / Q000502:physiology / Q000627:therapeutic use*
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D013972:Thyrotropin; D015032:Zinc; D013974:Thyroxine