[Weekly hepatic arterial infusion of high-dose 5-FU for liver metastases from colorectal cancer].
A study was conducted on weekly infusion of high-dose 5-FU by way of the hepatic artery for liver metastases from colorectal cancer. In the evaluation of 13 cases, no CR and 6 PR were observed. The response rate was 46.2%, 1-year survival was 73% and 1.5-year survival was 42%. No patients suffered from major side effects. Two patients had ileus, which was controllable by supportive care with intravenous hyperalimentation, and was caused by peritoneal dissemination of cancer. In conclusion, this regimen was relatively safe, effective, and useful for improving the quality of life of patients, compared with other regimens. How to control extrahepatic metastases in addition to this regimen is a subject for forthcoming study.
Motohara
T
T
Dept. of Radiology, Kochi Municipal Central Hospital.
Ogawa
K
K
Morita
S
S
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D015996:Survival Rate
D005472:Fluorouracil