Two bioactive pterocarpans from Erythrina burana.
Bioactivity-directed fractionation of the CHCl3 extract of the bark of Erythrina burana afforded phaseollidin [1] and cristacarpin [2]. Both 1 and 2 exhibited moderate but selective activity towards DNA repair-deficient yeast mutants, whereas only 1 was found to be cytotoxic. 13C-nmr spectra of both compounds were assigned.
Dagne
E
E
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
Gunatilaka
A A
AA
Kingston
D G
DG
Alemu
M
M
Hofmann
G
G
Johnson
R K
RK
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005002:Ethiopia; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D036343:Pterocarpans; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics
D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D001578:Benzopyrans; D036343:Pterocarpans; C085158:phaseollidin; C085157:cristacarpin