Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.
Stahl
N
N
Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Boulton
T G
TG
Farruggella
T
T
Ip
N Y
NY
Davis
S
S
Witthuhn
B A
BA
Quelle
F W
FW
Silvennoinen
O
O
Barbieri
G
G
Pellegrini
S
S
D000818:Animals; D015703:Antigens, CD; D002460:Cell Line; D020934:Ciliary Neurotrophic Factor; D050822:Cytokine Receptor gp130; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology*; D004789:Enzyme Activation; D006131:Growth Inhibitors; D015850:Interleukin-6; D053613:Janus Kinase 1; D053614:Janus Kinase 2; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000494:pharmacology; D053683:Oncostatin M; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D020801:Receptor, Ciliary Neurotrophic Factor; D018121:Receptors, Cytokine / Q000378:metabolism*; D017978:Receptors, Growth Factor / Q000378:metabolism; D018123:Receptors, Interleukin / Q000378:metabolism; D019947:Receptors, Interleukin-6; D053606:Receptors, OSM-LIF; D053677:Receptors, Oncostatin M; D014443:Tyrosine / Q000378:metabolism
D015703:Antigens, CD; D020934:Ciliary Neurotrophic Factor; D016207:Cytokines; D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D010455:Peptides; D011506:Proteins; D011518:Proto-Oncogene Proteins; D020801:Receptor, Ciliary Neurotrophic Factor; D018121:Receptors, Cytokine; D017978:Receptors, Growth Factor; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6; D053606:Receptors, OSM-LIF; D053677:Receptors, Oncostatin M; D053683:Oncostatin M; D050822:Cytokine Receptor gp130; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; D053613:Janus Kinase 1; D053614:Janus Kinase 2