Documentation of complete resolution of gestational choriocarcinoma in the oophorectomized patient.
A 39-year-old woman with choriocarcinoma metastatic to the lungs and parametrium underwent total abdominal hysterectomy/bilateral salpingo-oophorectomy and follow-up chemotherapy with regression of the hCG assay, plateauing at 9 mIU/ml. Spinal fluid hCG assay was negative. An LH assay was performed which was 135 mIU/ml (2nd IRP-HMG). A quantitative hCG assay was performed on two sources of purified LH at varying concentrations to determine the contribution of LH cross-reactivity. When corrected for the LH contribution, the quantitative hCG was zero. Chemotherapy was discontinued. At 12-months follow-up the patient has remained in complete chemical remission and has an excellent performance status. Whenever a patient is oophorectomized, LH cross-reactivity should be ruled out as a cause for persistent low titers of hCG.
O'Hanlan
K A
KA
Department of Gynecology and Obstetrics, Stanford University School of Medicine, California 94305-5317.
Wu
T F
TF
Teng
N N
NN
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000188:drug therapy / Q000601:surgery*; D006063:Chorionic Gonadotropin / Q000032:analysis; D003131:Combined Modality Therapy; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008175:Lung Neoplasms / Q000556:secondary; D007986:Luteinizing Hormone / Q000032:analysis; D010052:Ovariectomy; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000601:surgery*
D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone