title: S100a0 protein as a marker for tissue damage related to extracorporeal shock wave lithotripsy.
abstract: We assayed serum and urine S100a0 protein levels in patients with renal stones (n = 21) or ureteral stones (n = 18), before and after extracorporeal shock wave lithotripsy (ESWL) to evaluate tissue injury. Serum S100a0 protein levels increased significantly immediately after, and at 2 and 24 h after ESWL in patients with renal stones, and at 2 and 24 h after ESWL in patients with ureteral stones. Significant increases in urine S100a0 protein levels were observed immediately and 2 h after ESWL in both groups of patients. The patients receiving a higher number of shock waves had a more pronounced increase in serum S100a0 protein especially in the case of more than 3,500 shock waves. Because S100a0 protein exists at relatively high concentrations in the proximal renal tubules and skeletal muscles, serum and urine S100a0 protein levels appear to be useful markers of tissue injury, including damage in the kidney and skeletal muscles, in the early post-ESWL phase.
authors.affiliation: Department of Urology, Nagoya University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Takashi
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.forename: K
authors.initials: K
authors.lastname: Obata
authors.forename: K
authors.initials: K
authors.lastname: Miyake
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D005260:Female; D006801:Humans; D007668:Kidney / Q000293:injuries; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000293:injuries; D009418:S100 Proteins / Q000032:analysis*; D014545:Urinary Calculi / Q000628:therapy; D014947:Wounds and Injuries / Q000175:diagnosis
chemical_list: D015415:Biomarkers; C030564:S-100 calcium-binding protein alpha subunit; D009418:S100 Proteins