Experimental seizure-induced brain damage: electrophysiological, metabolic and pathological correlation.
Limbic seizures elicited by an intra-amygdaloid KA injection is the only and unique model which can produce unilateral hippocampal degenerative lesions and atrophy. This model is important not only to investigate neurophysiological epileptogenesis but also to study the causative process of human mesial temporal sclerosis observed in patients with intractable complex partial seizure.
Tanaka
T
T
Department of Neurosurgery, Asahikawa Medical College, Japan.
Fujita
T
T
Yamamoto
K
K
Fukuda
H
H
Yonemasu
Y
Y
D000679:Amygdala / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001345:Autoradiography; D001786:Blood Glucose / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D002118:Calcium / Q000378:metabolism; D002415:Cats; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D006863:Hydrogen-Ion Concentration; D007608:Kainic Acid / Q000633:toxicity; D008032:Limbic System / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*
D001786:Blood Glucose; D011963:Receptors, GABA-A; D007608:Kainic Acid; D002118:Calcium