[The adaptive response of B cells to the action of cytotoxic preparations in culture. II. Immunoglobulin interaction with adriamycin and ethidium bromide].
The binding of adriamycin and ethidium bromide coupled to sepharose beads with intracellular and serum immunoglobulins is detected. These drugs do not bind with Fab and Fc fragments of immunoglobulin. The binding of ethidium bromide to immunoglobulins is competitive. Possible adaptive features of this phenomenon are discussed.
Davtian
T K
TK
Meliksetian
M B
MB
Aleksanian
Iu T
IuT
Ignatova
T N
TN
D000222:Adaptation, Physiological / Q000187:drug effects*; D000345:Affinity Labels; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001667:Binding, Competitive / Q000187:drug effects; D002460:Cell Line; D004317:Doxorubicin / Q000032:analysis / Q000493:pharmacokinetics*; D004347:Drug Interactions; D004351:Drug Resistance; D004591:Electrophoresis, Polyacrylamide Gel; D004996:Ethidium / Q000032:analysis / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D006801:Humans; D006825:Hybridomas / Q000276:immunology / Q000378:metabolism; D015151:Immunoblotting; D007136:Immunoglobulins / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000378:metabolism
D000345:Affinity Labels; D007136:Immunoglobulins; D004317:Doxorubicin; D004996:Ethidium
Adaptivnyĭ otvet B-kletok na deĭstvie tsitotoksicheskikh preparatov v kul'ture. II. Vzaimodeĭstvie immunoglobulinov s adriamitsinom i bromistym étidiem.