title: The human phenolsulphotransferase polymorphism is determined by the level of expression of the enzyme protein.
abstract: We have examined the expression of platelet phenolsulphotransferase (PST) in 60 individuals. Using an antibody which recognizes both forms of PST present in man (P-PST and M-PST), we determined that the polymorphism of platelet P-PST activity is determined by the level of expression of the enzyme protein. The implications for susceptibility to adverse drug reactions and chemical carcinogenesis are discussed.
authors.affiliation: Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, U.K.
authors.forename: A L
authors.initials: AL
authors.lastname: Jones
authors.forename: R C
authors.initials: RC
authors.lastname: Roberts
authors.forename: M W
authors.initials: MW
authors.lastname: Coughtrie
mesh_terms: D015239:Arylsulfotransferase / Q000097:blood* / Q000235:genetics* / Q000302:isolation & purification; D001792:Blood Platelets / Q000201:enzymology*; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003600:Cytosol / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D015151:Immunoblotting; D007527:Isoenzymes / Q000097:blood / Q000235:genetics* / Q000302:isolation & purification; D011110:Polymorphism, Genetic
chemical_list: D007527:Isoenzymes; D015239:Arylsulfotransferase