Tumor necrosis factor as a mediator of shock, cachexia and inflammation.
Tumor necrosis factor is a cytokine made by macrophages, monocytes and T cells that has been formed to play an important role in shock, cachexia and inflammation. The importance of this cytokine eliciting shock and cachexia in mammals is reviewed.
Cerami
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Picower Institute for Medical Research, Manhasset, N.Y. 11030.
D000818:Animals; D002100:Cachexia / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D012769:Shock / Q000503:physiopathology*; D012772:Shock, Septic / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha