title: Support for the shape concept of lipid structure based on a headgroup volume approach.
abstract: Headgroup volumes of seven dioleoyl lipid species, calculated from covalent radii, are shown to correlate linearly (r = 0.95) with the ability of those lipids to alter the midpoint temperature of the lamellar to inverted hexagonal phase transition (L alpha-->HII) of a 95 mole fraction percent phosphatidylethanolamine matrix. The results illustrate the utility of the shape concept and basic considerations of headgroup volume as a predictive tool for the determination of lipid structure.
authors.affiliation: Department of Pathology and Cell Biology, Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.forename: T F
authors.initials: TF
authors.lastname: Taraschi
authors.forename: N
authors.initials: N
authors.lastname: Janes
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D010712:Phosphatidic Acids / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D010712:Phosphatidic Acids; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C057561:1-palmitoyl-2-oleoylphosphatidylethanolamine