title: Factors influencing survival after resection of pancreatic cancer. A DNA analysis and a histomorphologic study.
abstract: BACKGROUND
  The influence of DNA content on prognosis in stomach cancer has been investigated rarely, and the results are controversial.
  
  
  METHODS
  The prognostic relevance of the DNA content and histomorphologic parameters was evaluated in 41 patients after resection of pancreatic cancer.
  
  
  RESULTS
  In the univariate analysis, the DNA content, tumor size, lymph node status, tumor stage, nuclear grade, and type of resection had a statistically significant influence on the prognosis. No association was found between the DNA content and the histomorphologic features. Apart from the operative procedure, the DNA content was the strongest indicator of prognosis in the multivariate analysis.
  
  
  CONCLUSIONS
  Further investigations are necessary to find out if DNA analysis can be performed preoperatively on material obtained by fine-needle aspiration.
authors.affiliation: Department of Surgery, Johannes Gutenberg University, Mainz, West Germany.
authors.forename: T C
authors.initials: TC
authors.lastname: Böttger
authors.forename: S
authors.initials: S
authors.lastname: Störkel
authors.forename: S
authors.initials: S
authors.lastname: Wellek
authors.forename: M
authors.initials: M
authors.lastname: Stöckle
authors.forename: T
authors.initials: T
authors.lastname: Junginger
mesh_terms: D002467:Cell Nucleus / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D004171:Diploidy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D011123:Polyploidy; D011379:Prognosis; D015996:Survival Rate
chemical_list: D004273:DNA, Neoplasm