[Prognostic factors of hepatocellular carcinoma. Multifactorial analysis of 84 cases].
To identify prognostic factors taking in account recent advances in diagnosis and treatment, 24 clinical, biological, and morphological factors were evaluated by means of uni- and multivariate analysis in 84 patients with hepatocellular carcinoma diagnosed between 1984 and 1991. Okuda's grading (P < 0.01), creatininemia (P < 0.01), and treatment (P < 0.05) were independent prognostic factors. Des-gamma-carboxyprothrombin reached a significant level (P < 0.05) in a subgroup of 32 recent patients but its prognostic value needs to be confirmed. Further prospective randomized trials comparing surgical and non-surgical treatment should take these factors into account.
Razafimahaleo
A
A
Service d'Hépato-Gastroentérologie, CHU Nord, Amiens.
Burtin
P
P
Joly
J P
JP
Dupas
J L
JL
Capron-Chivrac
D
D
Capron
J P
JP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000401:mortality* / Q000628:therapy; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011516:Prothrombin / Q000032:analysis
D011516:Prothrombin; D003404:Creatinine
Facteurs pronostiques du carcinome hépatocellulaire. Analyse multifactorielle de 84 cas.