[Participation of tocopherol and its analogs in lipid peroxidation processes and electron transport in rat liver mitochondria in vivo].
The effects of vitamin E and its analogs--alpha-tocopheryl acetate with a shortened up to six carbon atoms side chain carrying a saturated and an unsaturated bonds at the chain terminus, alpha-tocopherol and alpha-tocopheryl quinone devoid of the side chain--on the rate of malonic dialdehyde formation, the diene conjugate and total lipid content in the liver as well as the activity of the respiratory chain enzymes--succinate--and NADH-dehydrogenase, succinate- and NADH-ubiquinone reductase, as well as the vitamin E and ubiquinone content in the liver mitochondria of vitamin E-deficient rats in vivo have been investigated. It has been found that alpha-tocopheryl acetate with a shortened (up to C6) side chain carrying a saturated bond at the chain terminus is the most effective analog of tocopherol. Further reduction of the tocopherol side chain or tocopherol conversion into quinone causes a decrease in their tocopherol activity.
Kunitsa
N I
NI
Kuz'menko
I V
IV
Alekseev
S M
SM
Zakharova
E I
EI
Donchenko
G V
GV
D000818:Animals; D004579:Electron Transport / Q000187:drug effects*; D042967:Electron Transport Complex I; D042963:Electron Transport Complex II; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology*
D009097:Multienzyme Complexes; D014451:Ubiquinone; D014810:Vitamin E; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases; D009245:NADH Dehydrogenase; D042967:Electron Transport Complex I
Uchastie tokoferola i ego analogov v protsessakh perekisnogo okisleniialipidov i transporta élektronov v mitokhondriiakh pecheni krys in vivo.