title: Genetic and biochemical studies of protein sorting to the yeast vacuole.
abstract: Studies of vacuolar protein sorting in yeast are revealing important new insights into the mechanisms of intracellular membrane trafficking. Recent work has raised questions about the prevailing view concerning membrane protein transport to the vacuole, and has indicated roles in vacuolar protein sorting for GTP-binding proteins, clathrin, a serine/threonine protein kinase and a phosphatidylinositol 3-kinase.
authors.affiliation: Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla 92093-0668.
authors.forename: J H
authors.initials: JH
authors.lastname: Stack
authors.forename: S D
authors.initials: SD
authors.lastname: Emr
mesh_terms: D002966:Clathrin / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D012995:Solubility; D014617:Vacuoles / Q000378:metabolism*
chemical_list: D002966:Clathrin; D005656:Fungal Proteins; D008565:Membrane Proteins; D019204:GTP-Binding Proteins