Plasmacytoma of the thoracic spine with intracellular amyloid and massive extracellular amyloid deposition.
A 65-year-old woman presented with back pain and a lytic destructive lesion of T-11. Fine-needle aspiration biopsy revealed a granulomatous reaction with unusual signet ring type cells and vacuolated histiocytes. Subsequent resection of the lesion revealed a fibrohistiocytic reaction with extensive amyloid deposition. Immunoperoxidase stains confirmed monotypic kappa light-chain staining. Ultrastructural examination of paraffin-embedded tissue confirmed extracellular amyloid deposition. A unique feature of this case was the finding of intracellular amyloid; the unusual signet ring cells were shown to be plasma cells with intracellular amyloid, and the vacuolated histiocytes also contained amyloid.
Arnesen
M
M
Department of Pathology 11136, Abbott Northwestern Hospital, Minneapolis, Minnesota 55407.
Manivel
J C
JC
D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D010954:Plasmacytoma / Q000378:metabolism / Q000648:ultrastructure*; D013125:Spinal Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D013904:Thoracic Vertebrae / Q000648:ultrastructure*
D000682:Amyloid