Gas chromatographic determination of zopiclone in plasma after solid-phase extraction.
A gas chromatographic technique for determining zopiclone based on a solid-phase extraction procedure with C18 cartridge for sample clean-up is presented. Quantification can be achieved with 1 ml of plasma. The method uses prazepam as internal standard. Zopiclone is separated on a 5% phenyl methyl silicone analytical column and detected with an electron-capture detector, which consequently allows a limit of quantitation of 2 micrograms/l. It is thus simple, rapid, sensitive and linear over the range 5-2000 micrograms/l.
Gaillard
Y
Y
Laboratoire Central de Pharmacologie et Toxicologie, Hôpital de Bellevue, Saint-Etienne, France.
Gay-Montchamp
J P
JP
Ollagnier
M
M
D053961:Azabicyclo Compounds; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood*; D010879:Piperazines / Q000097:blood*
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone