title: Mucociliary transport in ICU patients.
abstract: OBJECTIVE
  The objectives of this study were to determine the bronchial mucus transport velocities in ventilated ICU patients and to study the possible role of impaired mucus transport in the development of retention of secretion and pneumonia.
  
  
  METHODS
  The patients were studied prospectively in a convenience sample trial.
  
  
  METHODS
  The study took place at a university hospital.
  
  
  METHODS
  Thirty-two ventilated patients in a surgical ICU were included in the study. The study was approved by the Ethics Committee of the University of Ulm.
  
  
  METHODS
  Bronchial mucus transport velocity (BTV) was measured with a small volume of technetium 99m-labeled albumin microspheres within the first 3 days of mechanical ventilation. The radiolabeled bolus was deposited at the distal end of the right and left main bronchus via flexible bronchoscopy. The movement of the microspheres toward the trachea was visualized and recorded using a scintillation camera. After determination of BTV, the patients were examined daily for 4 days to record pulmonary complications (defined as retention of secretion and nosocomial pneumonia).
  
  
  RESULTS
  The median BTV in the right primary bronchus was 0.8 mm/min and in the left it was 1.4 mm/min. In nine patients both radioactive drops remained at the application site. In 14 patients, a total of 19 pulmonary complications occurred (10 times retention of secretion, 9 times pneumonia). Patients with pulmonary complications had statistically significant lower BTV compared with patients without pulmonary complications; in the left bronchus 0 (0 to 6.5) mm/min (median with range) vs 3.5 (0 to 10.5) mm/min (p < 0.01) and in the right bronchus 0 (0 to 3.0) mm/min vs 4.7 (0 to 11.7) mm/min (p < 0.01).
  
  
  CONCLUSIONS
  Ventilated patients in the ICU frequently have impaired mucus transport, which is associated with the development of retention of secretion and pneumonia.
authors.affiliation: Clinic for Anesthesiology, University of Ulm, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Konrad
authors.forename: T
authors.initials: T
authors.lastname: Schreiber
authors.forename: D
authors.initials: D
authors.lastname: Brecht-Kraus
authors.forename: M
authors.initials: M
authors.lastname: Georgieff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001980:Bronchi / Q000000981:diagnostic imaging / Q000378:metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology*; D009093:Mucus / Q000378:metabolism; D011014:Pneumonia / Q000209:etiology / Q000503:physiopathology; D011175:Positive-Pressure Respiration; D011877:Radionuclide Imaging; D012121:Respiration, Artificial; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin