[The mechanisms of the immunotropic effects of organophosphorus compounds].
The effects of acute poisoning with anticholinesterase insecticide dimethyldichlorvinylphosphate (DDVP) in doses 0.25; 0.5 and 1.0 LD 50, immobilisation stress (6-hour), hydrocortisone (100 mg/kg) and acetylcholine--A (5 mg/kg) on the basic immune responses were investigated in experiments on CBA mice. It was shown that increased migration of founder hemopoietic cells from the bone marrow was caused by the effect of A and that of T-cells from the thymus was induced by the actions of corticosterone (CS) and A. Suppressions of delayed-type hypersensitivity reaction, natural and antibody-dependent cellular cytotoxicity humoral immune response were directly associated with concentration of CS in the blood and inhibition of alpha-naphthylbutyratesterase in spleen cells. The function of nonspecific and specific mechanisms in the formation of immunodeficiency after intoxication with organophosphates chemicals was found to differ in immune resections under study.
Zabrodskiĭ
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D004006:Dichlorvos / Q000494:pharmacology / Q000506:poisoning; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000276:immunology
D009943:Organophosphorus Compounds; D004006:Dichlorvos; D000109:Acetylcholine; D006854:Hydrocortisone
Mekhanizmy immunotropnykh éffektov fosfororganicheskikh soedineniĭ.