A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39.
We have recently shown that a group of antimicrobial peptides of bovine neutrophils share highly identical pro-sequences. In this paper we report the cDNA sequence of a 172 amino acid residue pig myeloid protein showing a similar pro-sequence of 101 residues. The carboxyl-moiety of the predicted protein is identical to the mature form of the proline- and arginine-rich antibacterial peptide named PR-39, isolated from pig intestine.
Storici
P
P
National Laboratory of the Interuniversity Consortium for Biotechnology, (CIB), Trieste, Italy.
Zanetti
M
M
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides; D001483:Base Sequence; D001853:Bone Marrow / Q000378:metabolism*; D003001:Cloning, Molecular; D017931:DNA Primers; D018076:DNA, Complementary / Q000302:isolation & purification / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D011498:Protein Precursors / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D013552:Swine
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D017931:DNA Primers; D018076:DNA, Complementary; D010455:Peptides; D011498:Protein Precursors; C072212:PR 39