Monoclonal antibodies by genetic engineering: novel reagents for in vivo diagnosis and therapy.
In only a few years, the technology of antibody engineering has demonstrated its power and a variety of recombinant monoclonal antibodies are now being developed. Recent developments in gene manipulation have allowed the isolation of antibodies, including human antibodies, with or without immunization, by displaying functional antibody fragments on the surface of bacteriophage particles and directly selecting with antigen. In the present review some recent achievements in these areas are highlighted.
Canevari
S
S
Division of Experimental Oncology E, Istituto Nazionale Tumori, Milano, Italy.
Furlan
D
D
Mossa
A
A
Figini
M
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics* / Q000627:therapeutic use; D000914:Antibodies, Viral; D005818:Genetic Engineering; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D051379:Mice
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral