title: Relationship between the level of c-myc mRNA and histologic aggressiveness in thyroid tumors.
abstract: We investigated the relationship between the level of c-myc mRNA and histologic aggressiveness in thyroid tumors obtained at surgery. In thyroid carcinomas, there was a positive correlation between these two parameters, while in benign tumors there was no correlation between cellularity and the expression of the proto-oncogene c-myc. These results might be useful in the prognosis of thyroid tumors and consequently helpful in the management of the patient.
authors.affiliation: Department of Endocrinology, Fundación CIMAE, Hospital Israelita Ezrah, Buenos Aires, Argentina.
authors.forename: M I
authors.initials: MI
authors.lastname: Romano
authors.forename: M
authors.initials: M
authors.lastname: Grattone
authors.forename: M P
authors.initials: MP
authors.lastname: Karner
authors.forename: S
authors.initials: S
authors.lastname: Moiguer
authors.forename: F
authors.initials: F
authors.lastname: Tetelbaum
authors.forename: L A
authors.initials: LA
authors.lastname: Romano
authors.forename: E
authors.initials: E
authors.lastname: Illescas
authors.forename: R
authors.initials: R
authors.lastname: Padin
authors.forename: F
authors.initials: F
authors.lastname: Cueva
authors.forename: J A
authors.initials: JA
authors.lastname: Burdman
mesh_terms: D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology; D018265:Carcinoma, Papillary, Follicular / Q000235:genetics / Q000473:pathology; D016259:Genes, myc; D006801:Humans; D009361:Neoplasm Invasiveness; D009693:Nucleic Acid Hybridization; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger