title: Stability of fluconazole in an extemporaneously prepared oral liquid.
abstract: The stability of fluconazole in an extemporaneously prepared oral liquid was studied. An aqueous liquid formulation of fluconazole was prepared by reconstituting the powder from triturated 100-mg tablets with deionized water; the nominal fluconazole concentration was 1 mg/mL. Glass vials of the liquid were stored in the dark at 4, 23, and 45 degrees C and sampled immediately and after 1, 2, 3, and 15 days. Samples were analyzed in duplicate for fluconazole concentration by high-performance liquid chromatography. The concentration of fluconazole was virtually unchanged under all the storage conditions. The results were confirmed by analysis of variance. Fluconazole 1 mg/mL in an extemporaneously prepared oral liquid was stable at 4, 23, and 45 degrees C for up to 15 days.
authors.affiliation: School of Pharmacy, University of Wyoming, Cheyenne.
authors.forename: W
authors.initials: W
authors.lastname: Yamreudeewong
authors.forename: A
authors.initials: A
authors.lastname: Lopez-Anaya
authors.forename: H
authors.initials: H
authors.lastname: Rappaport
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage; D015725:Fluconazole / Q000737:chemistry*; D006801:Humans; D013696:Temperature
chemical_list: D015725:Fluconazole