Psychiatric disorders in patients with Fabry's disease.
OBJECTIVE
To determine the frequency and etiology of psychiatric complications in patients with Fabry's disease. Method-Retrospective analysis and review of the records of thirty-three patients with confirmed Fabry's disease.


RESULTS
Six patients (18%) developed psychiatric disorders. Five patients suffered depression and two of these patients committed suicide. One patient developed an acute confusional episode with subsequent development of behavioral changes as a complication of cerebrovascular disease.


CONCLUSIONS
Psychiatric disorders, most commonly depression, complicate Fabry's disease and contribute to the morbidity and mortality of this disease.
Grewal
R P
RP
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
D000328:Adult; D002220:Carbamazepine / Q000627:therapeutic use; D002561:Cerebrovascular Disorders / Q000150:complications; D004172:Diplopia / Q000150:complications; D000795:Fabry Disease / Q000150:complications* / Q000188:drug therapy / Q000201:enzymology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications*; D010146:Pain; D000519:alpha-Galactosidase / Q000097:blood / Q000378:metabolism
D002220:Carbamazepine; D000519:alpha-Galactosidase