title: [Risk factors for the development of recurrences in patients with breast carcinoma without axillary lymph node metastases].
abstract: The influence of a number of risk factors on development of tumour recurrence was studied retrospectively in a group of breast cancer patients without axillary lymph node metastases, all treated identically and with long follow-ups. Of 71 patients all data could be retrieved. This group had a median duration of follow-up of five years. Thirteen patients (18.3%) had had a recurrence of carcinoma after a median disease-free period of 41 months (range 3-124 months). These patients at the time when breast cancer was diagnosed had had a lower median age than patients who had remained free of tumour recurrence, 48 (40-70) as against 59.5 (30-81) years. Factors having a statistically significant prognostic importance for recurrence of tumour were age at the time of diagnosis of breast carcinoma, histological tumour grade and nuclear DNA content. Identifying groups of patients with a higher or lower risk of tumour recurrence appears possible by combination of risk factors. Although patients with breast cancer without axillary lymph node metastases are supposed to have a favourable prognosis, there appear to exist subgroups with a raised risk for development of a recurrence. These groups might be prime candidates for prospective randomized studies of the usefulness of adjuvant therapy.
authors.affiliation: Afd. Chirurgie, Academisch Ziekenhuis, Utrecht.
authors.forename: W L
authors.initials: WL
authors.lastname: Akkersdijk
authors.forename: J H
authors.initials: JH
authors.lastname: Pieters
authors.forename: J G
authors.initials: JG
authors.lastname: Smits
authors.forename: J T
authors.initials: JT
authors.lastname: de Kruif
authors.forename: I
authors.initials: I
authors.lastname: van der Tweel
authors.forename: P W
authors.initials: PW
authors.lastname: de Graaf
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D004273:DNA, Neoplasm / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D004273:DNA, Neoplasm
vernacular_title: Risicofactoren voor het ontstaan van recidieven bij patiënten met een mammacarcinoom zonder okselkliermetastasen.