Severe adenoviral nephritis following bone marrow transplantation: successful treatment with intravenous ribavirin.
Invasive adenovirus infection is recognized as an unusual cause of serious end-organ sequelae following BMT. Because symptomatic therapy may be inadequate for more serious infections, the use of investigational agents is justified. We describe a case of severe, progressive nephritis secondary to adenovirus serotype 11 following BMT. Treatment with i.v. ribavirin led to prompt clinical improvement and resolution of adenovirus excretion.
Liles
W C
WC
Fred Hutchinson Cancer Research Center, Seattle, WA.
Cushing
H
H
Holt
S
S
Bryan
C
C
Hackman
R C
RC
D000257:Adenoviridae Infections / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D016026:Bone Marrow Transplantation; D003556:Cystitis / Q000188:drug therapy / Q000382:microbiology; D006086:Graft vs Host Disease / Q000150:complications; D006470:Hemorrhage / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000628:therapy; D008297:Male; D009393:Nephritis / Q000188:drug therapy / Q000382:microbiology*; D012254:Ribavirin / Q000627:therapeutic use*; D016879:Salvage Therapy
D012254:Ribavirin