Macrophages in experimental Chagas' disease.
The foregoing provides a basis for considering that macrophages are important in basically every aspect of the host-parasite relationship in experimental Chagas' disease. The myriad of activities of macrophages and the diverse responses of these cells to T. cruzi and various stimulatory and inhibitory cytokines as measured both in vitro and in vivo are suggestive of the complexity of the cell-cell interactions of the host during the course of infection and the evasive activities of the parasite.
Kuhn
R E
RE
Wake Forest University, Winston-Salem, North Carolina.
D000818:Animals; D000913:Antibodies, Protozoan / Q000378:metabolism; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology; D003165:Complement System Proteins / Q000378:metabolism; D016207:Cytokines / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010587:Phagocytosis; D014349:Trypanosoma cruzi / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity
D000913:Antibodies, Protozoan; D016207:Cytokines; D009569:Nitric Oxide; D003165:Complement System Proteins