Analysis of the huntingtin gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of Huntington's disease and CAG repeat number.
Rubinsztein
D C
DC
East Anglian Regional Genetics Service Molecular Genetics Laboratory, Addenbrooke's NHS Trust, Cambridge, UK.
Barton
D E
DE
Davison
B C
BC
Ferguson-Smith
M A
MA
D017668:Age of Onset; D000483:Alleles; D001483:Base Sequence; D003550:Cystic Fibrosis / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005796:Genes; D006801:Humans; D006816:Huntington Disease / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid