title: [A new graphic method for evaluation of distribution volume on N-isopropyl-p-[123I]iodoamphetamine (IMP) SPECT].
abstract: We developed a new graphic method using N-isopropyl-p-[123I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (Vd) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of 123I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of 123I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean +/- SD; 26 +/- 6 ml/g). This method was clinically useful. We think that the distribution volume of 123I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism.
authors.affiliation: Department of Radiology, Niigata University School of Medicine.
authors.forename: I
authors.initials: I
authors.lastname: Odano
authors.forename: M
authors.initials: M
authors.lastname: Ohkubo
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ohtaki
authors.forename: E
authors.initials: E
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Hatano
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: T
authors.initials: T
authors.lastname: Yokoi
authors.forename: M
authors.initials: M
authors.lastname: Nishihara
mesh_terms: D000368:Aged; D000662:Amphetamines / Q000493:pharmacokinetics; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D020367:Iofetamine; D008297:Male; D008954:Models, Biological; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine