title: [Treatment of hematogenic osteomyelitis in newborns].
abstract: The authors studied the immunobiological condition of the newborn's organism and the process of bone structure reparation before and after direct immune hemotransfusions and transplantation of bone marrow with the stroma in a mixture with antibiotics into the focus of osteomyelitis in the bone of newborn infants with consideration for the clinical manifestations of the disease, the stage of osteomyelitis, and the efficacy of the applied treatment. The authors examined 215 newborns with acute hematogenous osteomyelitis. The predominant site of localization of acute hematogenous osteomyelitis in the newborn infants were the epimetaphyseal (54.5%) and metaphyseal (39.6%) parts of the long tubular bones. The donors were immediate relatives compatible according to the ABO system and the rhesus factor, who underwent complete examination for HIV infection, the Australia antigen, and the Wasserman reaction, and who were immunized preliminarily with the staphylococcus anatoxin. The authors note the favorable immediate and late-term results of treatment which were confirmed by radiological restoration of the bone structure. The immunological values testify to increase of cellular and humoral immunity. Study of the late-term results of treatment confirm the decrease of the number of orthopedic complications.
authors.forename: V S
authors.initials: VS
authors.lastname: Kononov
authors.forename: A S
authors.initials: AS
authors.lastname: Sultanalieva
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010019:Osteomyelitis / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D011292:Premedication; D013997:Time Factors; D065227:Transfusion Reaction; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Lechenie gematogennogo osteomielita novorozhdennykh.