title: Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33.
abstract: Heart fatty acid binding protein (hFABP) is an abundant 14-kDa cytosolic protein thought to be involved in trafficking of fatty acids from the plasma membrane to sites of beta-oxidation in mitochondria and peroxisomes and to the endoplasmic reticulum for lipid synthesis. A human hFABP cDNA isolated by polymerase chain reaction was used as a probe for in situ hybridization to metaphase chromosomes. A fragment of the gene for human hFABP was used as a probe for fluorescence in situ hybridization to metaphase chromosomes. The cDNA and genomic probes both localized the gene for human hFABP to chromosome 1p32-1p33.
authors.affiliation: Department of Biochemistry, Boston University School of Medicine, MA 02118.
authors.forename: R F
authors.initials: RF
authors.lastname: Troxler
authors.forename: G D
authors.initials: GD
authors.lastname: Offner
authors.forename: J W
authors.initials: JW
authors.lastname: Jiang
authors.forename: B L
authors.initials: BL
authors.lastname: Wu
authors.forename: J C
authors.initials: JC
authors.lastname: Skare
authors.forename: A
authors.initials: A
authors.lastname: Milunsky
authors.forename: H E
authors.initials: HE
authors.lastname: Wyandt
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000737:chemistry*; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D009363:Neoplasm Proteins; D016133:Polymerase Chain Reaction; D025521:Tumor Suppressor Proteins
chemical_list: D002352:Carrier Proteins; D015342:DNA Probes; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D004247:DNA