Synthetic enhancement in gene interaction: a genetic tool come of age.
Synthetic enhancement, in which one mutation exacerbates the severity of another, is a genetic interaction of increasing importance in biology. This review focuses on the logic of interpreting synthetic enhancement, and begins by comparing the phenomenon with genetic suppression.
Guarente
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Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
D000818:Animals; D009154:Mutation; D013489:Suppression, Genetic