Aneurysmal dilatation of ductus arteriosus during lipo-prostaglandin E1 therapy for diaphragmatic hernia.
We report a case of congenital diaphragmatic hernia in which aneurysmal dilatation of ductus arteriosus developed after lipo-prostaglandin E1 (PGE1) therapy for persistent fetal circulation. After surgery Lipo-PGE1 was used at a dosage of 5 ng/kg per minute from days 2-9 during which aneurysmal dilatation (7 mm in diameter) developed and remained thereafter. Ductus arteriosus ligation was then performed. Lipo-PGE1 may promote ductus arteriosus dilatation in cases of persistent fetal circulation.
Tohyama
M
M
Department of Paediatrics, Shinshu University, Matsumoto, Japan.
Baba
A
A
Tsuno
T
T
Aonuma
K
K
Komiyama
A
A
D000527:Alprostadil / Q000627:therapeutic use*; D000783:Aneurysm / Q000209:etiology* / Q000601:surgery; D003965:Diaphragmatic Eventration / Q000150:complications* / Q000601:surgery; D004373:Ductus Arteriosus; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications* / Q000188:drug therapy*; D013537:Sutures
D000527:Alprostadil