title: Breast-conserving treatment of early breast cancer. Results in a common clinical trial.
abstract: Results of large prospective trials, often based on selected series and optimal treatment techniques, indicate that breast conserving therapy is appropriate for most patients with early breast cancer. Questions remain regarding the therapeutic outcome in common practice. We report on a series of 206 consecutive, unselected patients treated with current radiotherapy procedures. The Kaplan-Meier evaluation showed 5- and 8-year survival rates (93%, 91%), distant disease-free survival rates (87%, 85%) and local relapse-free survival rates (90%, 88%) that were comparable to those of the conservative arms in reported randomised trials and to the data from retrospective studies reported by authoritative institutions. However, subanalysis according to prognostic factors such as menopausal status, age and axillary nodal status was of limited value, due to the small number of cases.
authors.affiliation: Unità Operativa di Radioterapia USL-30, University of Siena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pirtoli
authors.forename: A
authors.initials: A
authors.lastname: Bellezza
authors.forename: F
authors.initials: F
authors.lastname: Pepi
authors.forename: E
authors.initials: E
authors.lastname: Tucci
authors.forename: M
authors.initials: M
authors.lastname: Crociani
authors.forename: A M
authors.initials: AM
authors.lastname: Crastolla
authors.forename: M
authors.initials: M
authors.lastname: Farzad
authors.forename: M
authors.initials: M
authors.lastname: Bindi
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D008875:Middle Aged; D011879:Radiotherapy Dosage; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents