title: Proteins regulating Ras and its relatives.
abstract: GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and action. Their functions depend on their ability to alternate between inactive and active forms, and on their cellular localization. Numerous proteins affecting the GTPase activity, nucleotide exchange rates and membrane localization of Ras superfamily members have now been identified. Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, Maryland 20894.
authors.forename: M S
authors.initials: MS
authors.lastname: Boguski
authors.forename: F
authors.initials: F
authors.lastname: McCormick
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D006150:Guanine Nucleotides / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism*; D014166:Transferases / Q000378:metabolism; D020703:ras GTPase-Activating Proteins; D020663:ras Guanine Nucleotide Exchange Factors
chemical_list: D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D006150:Guanine Nucleotides; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D020663:ras Guanine Nucleotide Exchange Factors; D014166:Transferases; D020558:GTP Phosphohydrolases; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)