title: Carcinogenicity study of the emulsifier TOSOM and the release agent TOS in Wistar rats.
abstract: Groups of 60 Wistar rats of each sex were fed diets containing 3, 6 or 12% of the margarine emulsifier TOSOM (thermally oxidized soybean oil interacted with mono- and diglycerides of fatty acids) for 2.5 yr. In addition, three groups of 60 rats of each sex were fed two products of the release agent TOS (thermally oxidized soybean oil) in dietary levels of 1.2% TOS(G) (TOS from Grindsted Product A/S, Denmark) and 0.3 and 1.2% TOS(N) (TOS from Nexus Aps, Denmark), respectively for 2.5 yr. 120 rats of each sex fed a diet containing mono- and diglycerides served as controls. The diets given to all groups were isocaloric. Clinical appearance, food consumption, body weight and weight gain, survival, haematology, and clinical chemistry parameters were examined. Gross and histopathological examinations, including neoplastic and non-neoplastic lesions, were performed on all groups. Time to occurrence of tumours was recorded. No substance-related effect, including carcinogenicity, was found.
authors.affiliation: Institute of Toxicology, National Food Agency, Søborg, Denmark.
authors.forename: O
authors.initials: O
authors.lastname: Meyer
authors.forename: E
authors.initials: E
authors.lastname: Kristiansen
authors.forename: J
authors.initials: J
authors.lastname: Gry
authors.forename: C
authors.initials: C
authors.lastname: Madsen
authors.forename: P
authors.initials: P
authors.lastname: Olsen
authors.forename: I
authors.initials: I
authors.lastname: Thorup
mesh_terms: D000818:Animals; D004655:Emulsions; D005079:Excipients / Q000378:metabolism / Q000633:toxicity*; D005227:Fatty Acids / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D015994:Incidence; D008297:Male; D008383:Margarine; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D010084:Oxidation-Reduction; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000378:metabolism / Q000633:toxicity*; D015996:Survival Rate
chemical_list: D004655:Emulsions; D005079:Excipients; D005227:Fatty Acids; D013024:Soybean Oil; D008383:Margarine