In vitro cyanide release of four prussian blue salts used for the treatment of cesium contaminated persons.
Prussian blue salts are used in clinical practice as an antidote for the treatment of humans contaminated with radioactive cesium. A decomposition product of these Prussian blue salts may be the highly toxic cyanide. A method to simulate gastrointestinal cyanide-release was applied to four different Prussian blue salts: K3Fe[Fe(CN)6], Fe4[Fe(CN)6]3, NH4Fe[Fe(CN)6] (pur. and unpur.). Cyanide-release was higher in artificial gastric juice than in water and artificial intestinal juice. Under all conditions cyanide-release from Fe4[Fe(CN)6]3 was the lowest. Since Fe4[Fe(CN)6]3 also binds more cesium, it appears to be the most suitable Prussian blue salt for use as an antidote after radiocesium contamination in humans.
Verzijl
J M
JM
Department of Hospital Pharmacy, Central Military Hospital, Utrecht, The Netherlands.
Joore
H C
HC
van Dijk
A
A
Wierckx
F C
FC
Savelkoul
T J
TJ
Glerum
J H
JH
D000931:Antidotes / Q000737:chemistry* / Q000627:therapeutic use; D002586:Cesium / Q000506:poisoning; D002588:Cesium Radioisotopes; D005295:Ferrocyanides / Q000737:chemistry* / Q000627:therapeutic use; D005750:Gastric Juice / Q000737:chemistry*; D006801:Humans; D006856:Hydrogen Cyanide / Q000737:chemistry*; D011832:Radiation Injuries / Q000188:drug therapy; D011853:Radiobiology
D000931:Antidotes; D002588:Cesium Radioisotopes; D005295:Ferrocyanides; D002586:Cesium; D006856:Hydrogen Cyanide; C000170:ferric ferrocyanide