[Histoplasmosis of the central nervous system. Clinical aspects in 8 patients].
Clinical approach has been made in eight patients with histoplasmosis of the central nervous system. All patients had no evidence of immunodepression. Time disease at diagnosis ranged from 6 to 108 months (median 36 months). Main signs and symptoms were: intracranial hypertension in 6 patients; impairment of memory in 4; confusion in 4; seizures in 2; urinary incontinence in 2; sexual impotency in 1. Meningo-encephalitic form was present in 6 patients, while the granulomatous form was found in 2. Diagnostic confirmation was based on: biopsy, in 1 case; necropsy, in 2 cases; cerebrospinal fluid (CSF) sediment culture, in 1; detection of antibodies against Histoplasma capsulatum in the CSF, in 5 cases. There was, in all patients, an expressive difference between CSF alterations (intense, merging acute and chronic phase elements) and clinical symptomatology (patients in general oligosymptomatic).
Machado
L R
LR
Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Brasil.
Nóbrega
J P
JP
Livramento
J A
JA
Vianna
L S
LS
Spina-França
A
A
D000293:Adolescent; D000328:Adult; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D002648:Child; D005260:Female; D006660:Histoplasmosis / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged
Histoplasmose do sistema nervoso central. Aspectos clínicos em oito pacientes.