title: Medium-term results of oral and intravenous omeprazole/amoxicillin Helicobacter pylori eradication therapy.
abstract: OBJECTIVE
  The aim of the present study was to examine the effect of the application route of the antibiotic amoxicillin in Helicobacter pylori eradication, using omeprazole/amoxicillin.
  
  
  METHODS
  In a prospective medium-term study, 31 patients with H. pylori-positive gastroduodenal ulcer disease were treated with a 14-day course of 20 mg omeprazole bid orally, combined with either 1 g amoxicillin tid intravenously (n = 15) or 500 mg amoxicillin six times daily orally (n = 16).
  
  
  RESULTS
  H. pylori eradication, defined as negative bacterial findings in urease test, culture, and histology at least 4 wk after cessation of study medication, was achieved in 93% (14/15) of the patients in the first group and in 91% (11/12) of the patients in the second group. To obtain medium-term results, patients in whom H. pylori had been successfully eradicated were investigated with a 13C-urea breath test at least 6 months later. Medium-term eradication rates of 91% (10/11 patients) in the first and 100% (10/10 patients) in the second group were observed.
  
  
  CONCLUSIONS
  In view of the equally high eradication rates obtained by a 14-day course of intravenously administered amoxicillin and an oral therapy of the same length and dosage, during the necessary induction of luminal hypoacidity by the proton pump inhibitor omeprazole, we conclude that the route of administration of amoxicillin does not play a decisive role in bacterial eradication.
authors.affiliation: Department of Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany.
authors.forename: R J
authors.initials: RJ
authors.lastname: Adamek
authors.forename: M
authors.initials: M
authors.lastname: Wegener
authors.forename: J
authors.initials: J
authors.lastname: Labenz
authors.forename: M
authors.initials: M
authors.lastname: Freitag
authors.forename: W
authors.initials: W
authors.lastname: Opferkuch
authors.forename: G H
authors.initials: GH
authors.lastname: Rühl
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage*; D001944:Breath Tests; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D010437:Peptic Ulcer / Q000188:drug therapy*; D011446:Prospective Studies; D013276:Stomach Ulcer / Q000188:drug therapy; D014508:Urea / Q000032:analysis
chemical_list: D000658:Amoxicillin; D014508:Urea; D009853:Omeprazole