title: Proteins immunologically related to erythrocyte anion transporter band 3 are altered in brain areas affected by Alzheimer's disease.
abstract: Proteins immunologically related to the human erythrocyte anion transporter band 3 are present in neurons of the human neocortex and hippocampus. Immunocytochemical studies show increased band 3 immunoreactivity in neurons in the brains of patients with Alzheimer's disease. Immunoblot studies show the presence of band 3-like molecules in brain membrane fractions, and suggest changes in expression and/or processing of band 3-like molecules in Alzheimer's disease-affected regions. We postulate that alterations in membrane-bound, band 3-like molecules may reflect termination of neuronal lifespan in Alzheimer's disease.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Nijmegen, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Bosman
authors.forename: F P
authors.initials: FP
authors.lastname: Van Workum
authors.forename: K
authors.initials: K
authors.lastname: Renkawek
authors.forename: P J
authors.initials: PJ
authors.lastname: Van Kalmthout
authors.forename: I G
authors.initials: IG
authors.lastname: Bartholomeus
authors.forename: W J
authors.initials: WJ
authors.lastname: De Grip
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D001457:Anion Exchange Protein 1, Erythrocyte / Q000276:immunology / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000378:metabolism
chemical_list: D001457:Anion Exchange Protein 1, Erythrocyte; D008565:Membrane Proteins