[Expression of EGF-R in gastric carcinoma and precancerous lesion].
The expression of epidermal growth factor receptor (EGF-R) in normal gastric mucosa, gastric mucosal dysplasia, early and advanced gastric carcinoma was studied with the monoclonal antibody to EGF-R by using immunohistochemical ABC method. Normal gastric mucosa was negative for EGF-R, but a relatively high positive rate was found in dysplasia. When gastric carcinoma occurred, the positive rate decreased. The expression of EGF-R was related to the poor differentiation and strong infiltration of gastric carcinoma. The carcinoma with the expression of EGF-R was easy to metastasize to lymph nodes. The result suggests that EGF-R might play some role in the process of carcinogenesis of gastric mucosa, and be used as a useful marker for the assessment of the biological behavior of gastric carcinoma.
Mi
J Q
JQ
Cancer Hospital, Shanghai Medical University.
D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D066246:ErbB Receptors / Q000032:analysis*; D005753:Gastric Mucosa / Q000737:chemistry; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D066246:ErbB Receptors