Modulation of hepatic fibrogenesis by antioxidants.
The oxidative damage of liver tissue appears to favour a fibrogenic process, through the stimulation of TGF beta 1 and procollagen gene expression. The latter effect has been also showed by a well defined end-product of lipid peroxidation, 4-hydroxy-2,3-nonenal in human Ito cell culture. "In vivo" and "in vitro" data give evidence of a strong down modulation of TGF beta 1 and collagen expression afforded by supplementation with different antioxidant molecules.
Poli
G
G
Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Italy.
Parola
M
M
Leonarduzzi
G
G
Pinzani
M
M
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D011347:Procollagen / Q000096:biosynthesis; D016212:Transforming Growth Factor beta / Q000096:biosynthesis
D000975:Antioxidants; D016207:Cytokines; D011347:Procollagen; D016212:Transforming Growth Factor beta