[Corticotrope].
Gene structure, transcription and processing of pro-opiomelanocortin (POMC) are described. Some of the regulatory factors for POMC gene transcription are also discussed. POMC gene consists of three exons and two relatively large introns. The exon-1 encodes 5' untranslated region and exon-2 encodes mostly signal peptide and N-terminal peptide of POMC. Exon 3 encodes all of the biologically active peptides contained in POMC. The translation product from mRNA is glycosylated and processed by peptidases to generate ACTH, beta-LPH, gamma-LPH and beta-endorphin in the anterior pituitary. However, in the neurointermediate lobe of the pituitary, ACTH is further processed to alpha-MSH and corticotropin-like intermediate peptide and beta-endorphin is processed to acetyl-beta-endorphin.
Tanaka
K
K
Third Department of Medicine, Teikyo University School of Medicine.
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation; D006031:Glycosylation; D006801:Humans; D010902:Pituitary Gland / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D001615:beta-Endorphin / Q000378:metabolism
D012333:RNA, Messenger; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone