[The effect of synthetic enkephalin analogs on the development of traumatic brain edema].
Experiments in rats showed i. p. injections of a dose of 0.1 mg/kg of highly mu-selective agonist DAGO, relatively selective delta-receptor agonist DSLET and Tyr-D-Ala-Gly-MePhe-Leu-Arg-NH-Et to attenuate markedly the development of cerebral edema 24 hours after brain injury. The same effect was found with administration of DSLET 4 days after trauma. Naloxone (1 mg/kg, i. p.) had no effect on this process, but completely blocked protective effect of peptides. These data demonstrate that both mu and delta opioid receptors are involved in the pathogenesis of traumatic cerebral edema.
Novikov
V E
VE
Iasnetsov
V V
VV
D000818:Animals; D001929:Brain Edema / Q000209:etiology*; D001930:Brain Injuries / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D004745:Enkephalins / Q000494:pharmacology*; D005260:Female; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D013997:Time Factors
D004745:Enkephalins; D011957:Receptors, Opioid; D009270:Naloxone
Vliianie sinteticheskikh analogov énkefalinov na razvitie travmaticheskogo oteka golovnogo mozga.