Use of hydroxylamine in improving radio protection of a combination of 5-hydroxy L-tryptophan and a thiol compound (AET) in small mammals.
Radioprotective effectiveness has been evaluated by 30 day survival studies and protection to bone-marrow cells in mice after radiation exposure and this has been further established by 24 hr deoxycytidine excretion in urine of rats following 5 Gy whole body gamma irradiation and protection to superoxide dismutase enzyme in marrow cells and red blood corpuscles. Radioprotective effectiveness as well as the duration of radioprotection have been improved by the administration (ip) of hydroxylamine (20 mg/kg), a decarboxylase inhibitor, prior to the use of a combination of 5-hydroxy L-tryptophan (5-HTP, 70 mg/kg) and 2-aminoethylisothiuronium bromide hydrobromide (AET, 20 mg/kg) ip in small mammals before whole body gamma irradiation.
Basu
S K
SK
Radiation Biology Division, Institute of Nuclear Medicine and Allied Sciences Lucknow Marg, Delhi, India.
Srinivasan
M N
MN
Chuttani
K
K
D006916:5-Hydroxytryptophan / Q000008:administration & dosage; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage
D006898:Hydroxylamines; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D019811:Hydroxylamine; D006916:5-Hydroxytryptophan; D013482:Superoxide Dismutase