title: Regulation of neuronal differentiation by retinoic acid alone and in cooperation with thyroid hormone or hydrocortisone.
abstract: Cultures highly enriched in neurons obtained from embryonic mouse cerebra were used to demonstrate that: (1) at the optimum concentration of 10(-8) M retinoic acid stimulated the neurons to produce axon- and dendrite-like structures as determined by phase contrast and fluorescent microscopy; (2) the same concentration of retinoic acid stimulated acetyl cholinesterase and choline acetyltransferase activities; (3) treatment of neurons of either prenatal or neonatal equivalent age with retinoic acid produced a sustained stimulation of neuronal differentiation, and (4) retinoic acid cooperatively stimulated neuronal differentiation with either thyroid hormone or hydrocortisone.
authors.affiliation: Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140.
authors.forename: H S
authors.initials: HS
authors.lastname: Ved
authors.forename: R A
authors.initials: RA
authors.lastname: Pieringer
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000196:embryology*; D003712:Dendrites / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D013963:Thyroid Hormones / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D013963:Thyroid Hormones; D014212:Tretinoin; D006854:Hydrocortisone