Nickel sulfate-specific suppressor T cells induced by nickel sulfate in drinking water.
Suppressor T cell function was studied in nickel sulfate (NiSO4) delayed type hypersensitivity (DTH). NiSO4 in drinking water administered orally to normal mice for 10 weeks elicited no significant footpad swelling. However, after drinking water for 7 weeks, suppression of footpad swelling response was not detected. Suppression of footpad swelling response was mediated by CD4-8+ T cells. However, these suppressor T cells did not overcome CD4+8- helper T cells by co-transfer to recipient mice. Unresponsiveness to NiSO4 by oral administration of antigen was due to suppressor T cells.
Ishii
N
N
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Moriguchi
N
N
Nakajima
H
H
Tanaka
S
S
Amemiya
F
F
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D016516:CD4-CD8 Ratio; D004326:Drinking; D004342:Drug Hypersensitivity / Q000276:immunology; D004487:Edema / Q000139:chemically induced; D005528:Foot; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology*; D007108:Immune Tolerance; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D009532:Nickel / Q000008:administration & dosage* / Q000097:blood / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors; D014867:Water
D000911:Antibodies, Monoclonal; D014867:Water; C029938:nickel sulfate; D009532:Nickel