Effect of diethylnitrosamine on prostaglandin E and lipid peroxidation levels in rat's liver, lung and renal tissue.
We have investigated the generation of a prooxidant state and effect on prostaglandin E (PGE) levels after administration of diethylnitrosamine (DENA) to rats. Lipid peroxides were assayed by monitoring thiobarbituric acid (TBA) a reactive material. PGE--like activity was assayed by using bioassay procedure. Our results demonstrate that increased lipid peroxide and decreased PGE levels were found in a dose dependent manner in DENA injected groups when compared to control groups. According to these findings, it is suggested that there is a negative correlation between carcinogenic DENA induced lipid peroxidation and PGE in rat's liver, lung, and renal tissue.
Erbaş
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D
Department of Physiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ekmekçi
A
A
Aricioğlu
A
A
Koz
M
M
Ulküer
M
M
D000818:Animals; D004052:Diethylnitrosamine / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D004052:Diethylnitrosamine; D015232:Dinoprostone