Theophylline toxicity in a premature neonate--elimination kinetics of exchange transfusion.
Exchange transfusion was utilized in the treatment of a 1871 gram female, 32 weeks gestational age, who received an IV bolus of aminophylline at 11 h for the treatment of apnea, with subsequent tachycardia and hypotension. At 22 h, plasma theophylline was 369.29 mumol/L (67 mg/L). During a single volume exchange transfusion at 33 h, the plasma theophylline decreased 19% and the estimated removal of theophylline was 13.5% of the whole body theophylline. The theophylline apparent half-times before, during, and after the exchange were 52.5, 6.6, and 53.3 h respectively.
Osborn
H H
HH
New York City Poison Control Center, New York.
Henry
G
G
Wax
P
P
Hoffman
R
R
Howland
M A
MA
D062787:Drug Overdose; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*
D013806:Theophylline