title: Plumboporphyria (ALAD deficiency) in a lead worker: a scenario for potential diagnostic confusion.
abstract: A lead worker developed bilateral wrist drop. At first this seemed to be a lead neuropathy but all his screening tests for blood and urine toxicity had been within the accepted safety limit during employment. Detailed investigation showed that he had plumboporphyria (ALAD deficiency) which had been symptom free until he was exposed to lead. Details of his porphyrin metabolism are presented.
authors.affiliation: Department of Neurology, Leicester Royal Infirmary.
authors.forename: J
authors.initials: J
authors.lastname: Dyer
authors.forename: D P
authors.initials: DP
authors.lastname: Garrick
authors.forename: A
authors.initials: A
authors.lastname: Inglis
authors.forename: I F
authors.initials: IF
authors.lastname: Pye
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D007855:Lead Poisoning / Q000175:diagnosis*; D008297:Male; D016472:Motor Neuron Disease / Q000209:etiology; D009784:Occupational Diseases / Q000175:diagnosis*; D000623:Porphobilinogen Synthase / Q000172:deficiency*; D011164:Porphyrias / Q000175:diagnosis; D011166:Porphyrins / Q000378:metabolism
chemical_list: D011166:Porphyrins; D000623:Porphobilinogen Synthase