Effect of polyol type on the physical properties and thrombogenicity of sulfonate-containing polyurethanes.
Polyetherurethanes (PEUs) based on polytetramethylene oxide (PTMO) as the polyol, and derivatized with propyl sulfonate functionality, have previously been shown to possess antithrombotic properties. In this article, the bulk physical properties of sulfonated and nonsulfonated polyurethanes containing either polyethylene oxide (PEO) or PTMO as the soft segment are studied. The in vitro shape-change of platelets in contact with these surfaces, and their ex vivo blood-contacting response are also investigated. It was found that PEO-base was physically weaker than PTMO-base, which is attributed to a lower degree or phase separation in the former. In the dry state, sulfonation enhanced the physical properties for PTMO-containing polyurethane (PTMO-SO3-0.20), but weakened the PEO-containing polyurethane (PEO-SO3-0.15). In vitro platelet spreading studies showed the lowest degree of platelet spreading and also the lowest platelet density on PEO-base, while platelet spreading and density on the other three materials and polyethylene (PE) was greater. The thromboresistance of these materials was evaluated using a canine arteriovenous series shunt ex vivo. It was determined that PTMO-SO3-0.20 was the least thrombogenic, followed by both PEO-base and PEO-SO3-0.15, and that PTMO-base was the most thrombogenic.
Silver
J H
JH
Department of Chemical Engineering, University of Wisconsin, Madison 53706.
Marchant
J W
JW
Cooper
S L
SL
D017738:Alkanesulfonic Acids; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D004285:Dogs; D008422:Materials Testing; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011108:Polymers / Q000494:pharmacology*; D011140:Polyurethanes / Q000737:chemistry*; D013718:Tensile Strength; D013918:Thrombin Time
D017738:Alkanesulfonic Acids; D011108:Polymers; D011140:Polyurethanes; C024617:polyol; C068559:propylsulfonic acid