Relationship of IL-2, IL-2R (CD25+), soluble IL-2R and IL-4 with disease activity in SLE patients.
The plasma levels of interleukin-4 (IL-4), interleukin-2 (IL-2), soluble receptor of IL-2 (IL-2R) and T cell expression of IL-2 receptor chain (CD25+) were determined in an attempt to relate these parameters with disease activity in systemic lupus erythematosus (SLE). IL-4, IL-2 and sIL-2R plasma levels of SLE patients were significantly higher than those of the control group (P < 0.05) while CD25+ expression was similar in both groups. Only sIL-2R levels were significantly higher (P < 0.05) in active than in inactive patients.
Cuadrado
M J
MJ
Unit of Rheumatology, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Cordoba, Spain.
Marubayashi
M
M
Ortega
C
C
Fernandez-Arcas
N
N
Garcia-Cozar
F
F
Pena
J
J
Sanchez-Guijo
P
P
Santamaria
M
M
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000032:analysis / Q000097:blood*; D015847:Interleukin-4 / Q000032:analysis / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012995:Solubility; D013601:T-Lymphocytes / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D015847:Interleukin-4