In vitro transdermal delivery of atenolol using mouse and guinea pig.
In vitro percutaneous absorption of atenolol was done in order to assess its feasibility for transdermal development across mouse and guinea pig skins using Keshary-Chien type of diffusion cell. Values of diffusion rate (J) and permeability coefficient (Kp) across guinea pig skin were lowered as compared to those in mouse skin. When the concentration of drug in donor compartment was increased a decrease in Kp and increase in J value were observed with both the skins. Under the same conditions, values of J and Kp were lowered for dorsal skin compared to abdominal skin both for mouse and guinea pig. The results suggest that atenolol can be pursued further for transdermal system development.
Jain
G K
GK
College of Pharmacy, Pushp Vihar, Sector III, New Delhi, India.
Kaul
J L
JL
Agrawal
S S
SS
D000279:Administration, Cutaneous; D000818:Animals; D001262:Atenolol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010539:Permeability; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
D001262:Atenolol