title: Conclusions and implications of the systolic hypertension in the elderly program.
abstract: Isolated systolic hypertension has a higher prevalence with age and an associated excess cardiovascular risk. The Systolic Hypertension in the Elderly Program (SHEP) was a randomized, prospective, double blind clinical trial to assess the efficacy and safety of a antihypertensive regimen based on low dose diuretic therapy in reducing the five year combined incidence of fatal and nonfatal stroke. SHEP demonstrated a significant 36% reduction in stroke incidence. Also, 27% reduction in coronary heart disease incidence and a 32% reduction in major cardiovascular disease incidence were achieved. The benefits accrued to all subgroups identified based on baseline age, race, sex, blood pressure, serum cholesterol levels, and ECG abnormalities. A low-dose diuretic regimen should be the initial treatment of choice for most hypertensive patients, based on demonstrated reduction in risk for major cardiovascular events, its safety, acceptance by patients, and low cost.
authors.affiliation: School of Public Health, University of Texas Health Science Center, Houston 77030.
authors.forename: L A
authors.initials: LA
authors.lastname: Moyé
authors.forename: B R
authors.initials: BR
authors.lastname: Davis
authors.forename: C M
authors.initials: CM
authors.lastname: Hawkins
authors.forename: J L
authors.initials: JL
authors.lastname: Probstfield
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D001794:Blood Pressure; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D004232:Diuretics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D016019:Survival Analysis; D013599:Systole
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D001262:Atenolol