[The additive synthesis of a regulatory peptide in vivo: the administration of a vaccinal Francisella tularensis strain that produces beta-endorphin].
It has been shown, that vaccine strain of tularemia microbe, F.T.ISE., which produced recombinant beta-endorphin, when administered to CBA mice. It was shown to increase in the threshold level of pain sensitivity and is associated with peptides associated changes the stereotypic behavior. The observed correlated in time with the pattern of the dynamics of culture in the experimental animals and were associated with the level of recombinant beta-endorphin synthesis.
Borzenkov
V M
VM
Pomerantsev
A P
AP
Ashmarin
I P
IP
D000818:Animals; D001428:Bacterial Vaccines / Q000235:genetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005604:Francisella tularensis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D051379:Mice; D008808:Mice, Inbred CBA; D017288:Pain Threshold / Q000187:drug effects; D010957:Plasmids / Q000235:genetics; D011994:Recombinant Proteins / Q000494:pharmacology; D014169:Transformation, Bacterial; D001615:beta-Endorphin / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics / Q000494:pharmacology
D001428:Bacterial Vaccines; D011994:Recombinant Proteins; D001615:beta-Endorphin
Additivnyĭ sintez reguliatornogo peptida in vivo: vvedenie vaktsinnogo shtamma Francisella tularensis, produtsiruiushchego beta-éndorfina.