Determination of the percentage purity, active ingredients and other parameters in paracetamol and chloroquine syrups.
In this paper the percentage purity, active ingredients, specific gravity and the pH of paracetamol and chloroquine syrups were determined. For paracetamol the percentage purity ranged from 102.6-106.67, while the active ingredients (in mg/5 ml base) ranged from 123.2-128. The specific gravity ranged from 1.13-1.24 and the pH from 4.16-5.32. For the chloroquine the percentage purity ranged from 97-106.3, and the active ingredient 48.5-53.13, the specific gravity 1.17-1.27 and the pH 2.44-4.17. The results are discussed in relation to the purity, active ingredients and sources of the drugs. The drugs were coded. The paracetamol had a code of 1p-5p while the chloroquine was coded from 1c-5c.
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Department of Biochemistry, College of Medical Sciences, University of Calabar, Nigeria.
D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry / Q000592:standards* / Q000600:supply & distribution; D000284:Administration, Oral; D002738:Chloroquine / Q000008:administration & dosage / Q000737:chemistry / Q000592:standards* / Q000600:supply & distribution; D004340:Drug Contamination; D006863:Hydrogen-Ion Concentration; D009549:Nigeria; D004366:Nonprescription Drugs / Q000008:administration & dosage / Q000737:chemistry / Q000592:standards* / Q000600:supply & distribution; D011786:Quality Control; D013046:Specific Gravity; D013810:Therapeutic Equivalency
D004366:Nonprescription Drugs; D000082:Acetaminophen; D002738:Chloroquine