title: [Radioiodine therapy of thyrotoxicosis in a central hospital].
abstract: The aim of this study was to assess the results of 131-I therapy on hyperthyroidism. 131-I doses were individually calculated on the basis of thyroid gland classification, size and iodine-uptake. All patients were pretreated with propylthiouracil or methimazole. Seventy-nine patients treated with radio-iodine during the period 1.3.81-1.6.88 were followed up. The period of observation was 12-100 months (median 57). After eight years and four months the cumulative incidence of hypothyroidism was 45%, being 69% for diffuse goitre, 31% for multinodular goitre and 24% for solitary adenoma. A Cox-analysis showed a significantly greater cumulative incidence of hypothyroidism in patients with diffuse goitre as opposed to non-diffuse. From our data we conclude that radio-iodine therapy of hyperthyroidism with individually calculated doses of 131-I is a satisfactory method, assuming that patients are subjected to lifelong follow-up.
authors.affiliation: Medicinsk afdeling, Herning Centralsygehus.
authors.forename: H S
authors.initials: HS
authors.lastname: Sonne
authors.forename: B
authors.initials: B
authors.lastname: Larsen
authors.forename: V H
authors.initials: VH
authors.lastname: Asfeldt
mesh_terms: D000328:Adult; D000368:Aged; D000075202:Contraindications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D013971:Thyrotoxicosis / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes
vernacular_title: Radiojodterapi af tyreotoksikose på et centralsygehus.