Usefulness of a multiple biomarker assay in bronchoalveolar lavage (BAL) and serum for the diagnosis of small cell lung cancer.
To evaluate the diagnostic usefulness of simultaneous determinations of carcinoembryonic antigen (CEA), neuron specific enolase (NSE), chorionic gonadotrophin (HCG) and carbohydrate antigenic determinant 19-9 (CA 19-9), we studied 48 patients with small cell lung carcinoma (SCLC) and 15 with nonmalignant lung disease. The combination of CEA-BAL, NSE-BAL, and NSE-serum taken together with results of bronchoscopy (histologic and cytologic) showed the highest discriminating power between malignant (SCLC) and nonmalignant lung disease. The sensitivity of bronchoscopy alone was 35%. However, when bronchoscopy results were combined with 3 positive markers, the sensitivity increased to 71%, with at least 2 positive markers to 94%, and with at least 1 positive marker to 100%. When both bronchoscopy and all 3 markers were negative, the results showed a negative predictive value of 100%.
Nikliński
J
J
Department of Thoracic Surgery, Medical School, Białystok, Poland.
Chyczewska
E
E
Furman
M
M
Kowal
E
E
Laudanski
J
J
Chyczewski
L
L
D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D001999:Bronchoscopy; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000097:blood; D018288:Carcinoma, Small Cell / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000097:blood; D003937:Diagnosis, Differential; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000097:blood
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D010751:Phosphopyruvate Hydratase