Inositol trisphosphate/Ca2+ as a major signal transduction pathway from bradykinin receptors.
Enzymatic phosphatidylinositol-4,5-bisphosphate breakdown is not Ca(2+)-dependent in NG108-15 cells and the bradykinin-induced response consisted of at least two distinct components in the hybrid cells. The initial signal transduction from bradykinin receptors to acetylcholine secretion is composed of the inositol-1,4,5-trisphosphate-dependent Ca2+ pathway despite multiple pathways in the late phase.
Higashida
H
H
Department of Biophysics, Kanazawa University School of Medicine, Japan.
Kimura
Y
Y
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D004533:Egtazic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007293:Inosine Triphosphate / Q000502:physiology*; D051379:Mice; D009434:Neural Pathways / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D018002:Receptors, Bradykinin / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism
D018002:Receptors, Bradykinin; D007293:Inosine Triphosphate; D004533:Egtazic Acid; D010738:Type C Phospholipases; C025603:1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; D002118:Calcium