title: Amiprilose in the prevention of restenosis after coronary intervention in a swine model.
abstract: BACKGROUND
  Amiprilose hydrochloride is a synthetic carbohydrate with anti-inflammatory and antiproliferative properties. This study tested the potential benefit of amiprilose in preventing coronary artery restenosis in a swine model.
  
  
  METHODS
  The swine restenosis model was prepared using Hanford miniature swine made atherosclerotic with coronary abrasion, high-fat and high-cholesterol feeding, and intracoronary stenting. Eighteen animals were randomized to receive amiprilose, 100 mg/kg body weight orally twice per day (n = 9), or no amiprilose (n = 9) beginning 5 days before stenting and continuing through 4 weeks until sacrifice. Presacrifice quantitative coronary angiography and postsacrifice histologic examination revealed the degree of intimal proliferation.
  
  
  RESULTS
  Coronary angiography revealed no difference in percentage-diameter stenosis between the amiprilose and control groups (left anterior descending artery [LAD], 46% +/- 10% vs 44% +/- 17%; circumflex artery [CFX], 43% +/- 21% vs 42% +/- 15%; right coronary artery [RCA], 37% +/- 11% vs 34% +/- 9%; P = not significant [NS]), respectively, or in change in lumen diameter from poststenting to presacrifice (LAD, -1.0 +/- 0.4 mm vs -1.1 +/- 0.7 mm; CFX, -1.2 +/- 0.8 mm vs -1.0 +/- 0.7 mm; RCA, -1.1 +/- 0.4 mm vs -1.0 +/- 0.4 mm; P = NS). Morphometric histologic analysis likewise showed no difference in percentage-area stenosis (LAD, 55% +/- 14% vs 55% +/- 15%; CFX, 53% +/- 15% vs 54% +/- 12%; RCA, 39% +/- 17% vs 39% +/- 20%; P = NS) or in maximal intimal thickness.
  
  
  CONCLUSIONS
  Amiprilose hydrochloride did not prevent coronary intimal proliferation in this swine model of restenosis.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
authors.forename: W C
authors.initials: WC
authors.lastname: Grinstead
authors.forename: G P
authors.initials: GP
authors.lastname: Rodgers
authors.forename: W
authors.initials: W
authors.lastname: Mazur
authors.forename: D M
authors.initials: DM
authors.lastname: Cromeens
authors.forename: B A
authors.initials: BA
authors.lastname: French
authors.forename: M S
authors.initials: MS
authors.lastname: West
authors.forename: A E
authors.initials: AE
authors.lastname: Raizner
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017023:Coronary Angiography / Q000187:drug effects*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000473:pathology; D004036:Diet, Atherogenic; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012008:Recurrence; D012266:Ribose / Q000031:analogs & derivatives; D015607:Stents; D013552:Swine; D013556:Swine, Miniature
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012266:Ribose; D005944:Glucosamine; C018424:amiprilose