Postnatal gene transfer into the central nervous system.
Substantial progress has been made in the development of techniques for the expression of foreign genes in the central nervous system of postnatal animals. Fetal and adult brain cells and other cells, including fibroblasts and muscle cells, have been successfully employed as vehicles for foreign gene expression in the central nervous system. Direct gene transfer strategies, such as those using herpes and adenoviral vectors, are presently under intense and fruitful investigation.
Wolff
J A
JA
Department of Pediatrics, Waisman Center, University of Wisconsin, Madison 53705.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology / Q000502:physiology*; D002461:Cell Line, Transformed; D005347:Fibroblasts / Q000502:physiology; D015870:Gene Expression; D018014:Gene Transfer Techniques; D005821:Genetic Techniques; D009132:Muscles / Q000166:cytology