title: Effect of multidose intracorporeal injection and audiovisual sexual stimulation in vasculogenic impotence.
abstract: Erections are inhibited by sympathetic stimulation. Anxiety or psychologic inhibition may produce abnormal response during impotence workup. The use of intracorporeal alpha blockers (phentolamine) and audiovisual sexual stimulation (AVSS) has been used to decrease sympathetic outflow and enhance erectile response. Thirty-three patients with suspected vasculogenic impotence were studied. They underwent pulsed Doppler ultrasound (PDUS) with multiple doses of tri-mix (mix of papaverine, phentolamine, and prostaglandin E1). AVSS was applied after maximal response to tri-mix. Seventeen patients (51.5%) responded to multidose with grade IV or V erection. When AVSS was started, 5 more patients responded, and 7 upgraded to grade V with overall response of 40 percent. AVSS can augment the in-office response to pharmacologic testing above that obtained by "maximal" pharmacologic dosing, thereby increasing the sensitivity and specificity of the test.
authors.affiliation: Male Reproductive Medicine and Impotency Program, Cabrini Medical Center, New York University, New York.
authors.forename: N
authors.initials: N
authors.lastname: Katlowitz
authors.forename: G J
authors.initials: GJ
authors.lastname: Albano
authors.forename: G
authors.initials: G
authors.lastname: Patsias
authors.forename: M
authors.initials: M
authors.lastname: Golimbu
authors.forename: P
authors.initials: P
authors.lastname: Morales
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D010208:Papaverine / Q000008:administration & dosage* / Q000627:therapeutic use; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000098:blood supply; D010646:Phentolamine / Q000008:administration & dosage* / Q000627:therapeutic use; D010775:Photic Stimulation; D012039:Regional Blood Flow
chemical_list: D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine