title: The topical application of verapamil and nifedipine lowers intraocular pressure in conscious rabbits.
abstract: 1. The time-course of the ocular effects of topical verapamil and nifedipine as well as the dose-response relationship, were studied in conscious, normotensive rabbits. 2. Both drugs caused a dose-dependent fall of intraocular pressure, which lasted 4 hr or more. 3. Log dose-response curves of both drugs show a similar peak response, but the potency of verapamil was greater that of nifedipine. 4. A fall in the intraocular pressure in the untreated eye was also observed. 5. Verapamil and nifedipine induced a reduction of the tonographic outflow facility in the treated eye.
authors.affiliation: Departmento de Farmacología, Facultad de Farmacia, Universidad del País Vasco, Vitoria, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Segarra
authors.forename: J
authors.initials: J
authors.lastname: Santafé
authors.forename: M
authors.initials: M
authors.lastname: Garrido
authors.forename: M J
authors.initials: MJ
authors.lastname: Martínez de Ibarreta
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007429:Intraocular Pressure / Q000187:drug effects*; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014700:Verapamil; D009543:Nifedipine