[Hereditable characteristics of attenuated live hepatitis A virus H2 strain].
The toxicity of attenuated hepatitis A virus H2 strain was not increased in testing KMB 17 cells of 5 consecutive generations of monkeys at 36 degrees C. After injection of attenuated live hepatitis A virus H2 strain in humans, no abnormality was noted. Serum hepatitis A antigen was positive after 38 children aged 3-9 years were given oral 10(6.5) TCKD50, whereas it was 100% positive in the group of same age after percutaneous vaccination. Noninfection of oral administration is an important hereditable characteristic differentiation from wild strains.
Chai
S A
SA
Virus Research Institute, Zhejiang Academy of Medical Sciences, Huangzhou.
D000818:Animals; D000956:Antigens, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006506:Hepatitis A / Q000276:immunology / Q000517:prevention & control*; D006507:Hepatovirus / Q000145:classification / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008253:Macaca mulatta; D014613:Vaccines, Attenuated / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology
D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014761:Viral Hepatitis Vaccines