Clearance of exogenous parathyroid hormone-related protein in pregnant, non-pregnant and fetal sheep, goats and pigs.
In the sheep, goat and pig, radiolabelled parathyroid hormone related protein (PTHRP) and immunoreactive PTHRP(1-34) and (1-86) were rapidly cleared from the circulation. Metabolic clearance rates (MCR) were in the range of 1.25-7.5 ml/min per kg and were slightly slower than that of intact PTH in man (10 ml/min per kg); while the mean MCR of labelled PTHRP(1-86) in fetal sheep and goats was significantly faster than that in their respective mothers (14.4 vs 4.0 ml/min per kg respectively). This may reflect increased metabolism of PTHRP by fetal tissues, e.g. the placenta. Similar rates of clearance of radiolabelled PTHRP(1-141), (1-86) and (1-34) suggest that clearance involves the amino terminus of the molecule.
Ratcliffe
W A
WA
Wolfson Research Laboratories, Queen Elizabeth Medical Centre, Birmingham, U.K.
Abbas
S K
SK
Care
A D
AD
D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism; D006041:Goats / Q000097:blood*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D011506:Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012756:Sheep / Q000097:blood*; D013552:Swine / Q000097:blood*
D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins