Neurophysiological and psychological predictors of genetic risk for schizophrenia.
Mathematical genetic analyses were performed on a sample of schizophrenic families (25 probands and 58 first-degree relatives). Heritability coefficients were estimated for EEG power spectrum parameters and their topography, and also for psychological test data on thought and speech process disorder, designed to assess altered selectivity in cognitive activity. Multiple regression equations for genetic counseling regarding the prognosis of mental illness were derived from the neurophysiological and psychological measures.
Trubnikov
V
V
Prophylactic Psychiatry Research Institute, National Mental Health Research Center, Academy of Medical Sciences Russia, Moscow.
Uvarova
L
L
Alfimova
M
M
Orlova
V
V
Ozerova
N
N
Abrosimov
N
N
D000328:Adult; D001143:Arousal / Q000235:genetics* / Q000502:physiology; D001931:Brain Mapping / Q000295:instrumentation; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009483:Neuropsychological Tests; D010641:Phenotype; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D012564:Schizophrenic Language; D012565:Schizophrenic Psychology; D012815:Signal Processing, Computer-Assisted; D012931:Social Environment