Transport and sorting of membrane lipids.
The lipid composition of cellular membranes may seem unnecessarily complex. However, the lipid composition of each membrane is carefully regulated by local metabolism and specificity in transport, marking the functional significance for the cell. Recent research has revealed unexpected discoveries concerning the topology of lipid synthesis, specificity in lipid transport, and the function of lipid and protein microdomains in sorting.
van Meer
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Department of Cell Biology, Medical School, University of Utrecht, The Netherlands.
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D010712:Phosphatidic Acids / Q000378:metabolism; D013107:Sphingolipids / Q000096:biosynthesis / Q000378:metabolism
D008563:Membrane Lipids; D010712:Phosphatidic Acids; D013107:Sphingolipids; D002784:Cholesterol