title: Phase II trial of piroxantrone in patients with recurrent and metastatic squamous cell carcinoma of the head and neck. A Southwest Oncology Group trial.
abstract: Twenty-two patients with recurrent or metastatic squamous cell carcinoma of the head and neck were treated with piroxantrone 150 mg/m2 intravenously every 21 days. There were no objective responses. The 95% upper confidence bound for response is 15%. Primary toxicity was hematologic.
authors.affiliation: University of Kansas Medical Center, Kansas City.
authors.forename: S A
authors.initials: SA
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Benedetti
authors.forename: D
authors.initials: D
authors.lastname: Schuller
authors.forename: S P
authors.initials: SP
authors.lastname: Richman
authors.forename: G O
authors.initials: GO
authors.lastname: Broun
authors.forename: A
authors.initials: A
authors.lastname: Hantel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000880:Anthraquinones / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D011720:Pyrazoles; C046659:piroxantrone