title: Excluding blood donors at high risk of HIV infection in a west African city.
abstract: OBJECTIVE
  To examine the potential impact of deferral of blood donors at high risk of HIV infection in a west African city where blood is screened for HIV antibodies but no other special measures are taken to protect the blood supply.
  
  
  METHODS
  Cross sectional study.
  
  
  METHODS
  National Blood Transfusion Centre and Project RETRO-CI, an international collaborative AIDS research project, Abidjan, Côte d'Ivoire.
  
  
  METHODS
  1257 male first time blood donors.
  
  
  METHODS
  Blood donors were interviewed about demographic and behavioural characteristics and tested for HIV antibodies by enzyme immunoassay and, if positive, synthetic peptide based tests.
  
  
  METHODS
  HIV antibody status in relation to presence of behavioural risk factors; calculation of sensitivity, specificity, and predictive values of specific criteria for excluding HIV infected donors.
  
  
  RESULTS
  The overall prevalence of HIV infection was 11.4%. The most important risk factors for HIV positivity were prostitute contact and being aged 30-39 years. For identifying seropositive donors individual criteria had sensitivity, specificity, and positive predictive values ranging from 15% to 98%, 38% to 91%, and 17% to 30% respectively. Prostitute contact in the past five years would have excluded 31% of all donors and 73% of HIV infected donors. 27% of those excluded would have been HIV positive.
  
  
  CONCLUSIONS
  The widespread assumption that donor deferral is not feasible in sub-Saharan Africa needs reassessment. In Abidjan this approach was well accepted and potentially effective. Donor deferral requires evaluation as a strategy for improving blood safety in resource poor areas with high rates of HIV infection.
authors.affiliation: Centre National de Transfusion Sanguine, Abidjan, Côte d'Ivoire.
authors.forename: R
authors.initials: R
authors.lastname: Schutz
authors.forename: D
authors.initials: D
authors.lastname: Savarit
authors.forename: J C
authors.initials: JC
authors.lastname: Kadjo
authors.forename: V
authors.initials: V
authors.lastname: Batter
authors.forename: N
authors.initials: N
authors.lastname: Kone
authors.forename: G
authors.initials: G
authors.lastname: La Ruche
authors.forename: A
authors.initials: A
authors.lastname: Bondurand
authors.forename: K M
authors.initials: KM
authors.lastname: De Cock
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D007560:Cote d'Ivoire / Q000453:epidemiology; D003430:Cross-Sectional Studies; D015483:HIV Antibodies / Q000032:analysis*; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior
chemical_list: D015483:HIV Antibodies