Novel internal promoter/enhancer of HTLV-I for Tax expression.
The transcription initiation signals in retroviruses lie within the long terminal repeat (LTR) sequences. We have found a new transcriptional promoter in a central portion of the genome of human T-cell leukaemia virus type I (HTLV-I). The transcription start site is located just upstream to the ATG codon of the transcriptional trans-activator molecule, tax protein (Tax). The internal promoter may provide a new insight into gene expression of HTLV-I. The mechanism of leukaemogenesis by the defective HTLV-I is also discussed. Furthermore, we have identified two repeats of a novel enhancer sequence AGTTCT, which are located around the initiation site. We call the sequence HIRE (HTLV-I Internal Regulatory Element).
Nosaka
T
T
Institute for Virus Research, Kyoto University, Japan.
Ariumi
Y
Y
Sakurai
M
M
Takeuchi
R
R
Hatanaka
M
M
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004279:DNA, Viral; D004742:Enhancer Elements, Genetic; D016356:Gene Products, tax / Q000096:biosynthesis / Q000235:genetics*; D006367:HeLa Cells; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
D004279:DNA, Viral; D016356:Gene Products, tax