title: Piribedil could modify dopamine turnover in cochleas under noise stimulation.
abstract: Dopamine (DA) is one of the putative neurotransmitters of the lateral efferent olivocochlear fibers. The cochlear DA content after noise exposure was analyzed using high-performance liquid chromatography coupled with electrochemical detection. Animals were exposed for 1 h to white noise at 70, 90 or 110 dB SPL or were kept in conditions of silence. Half of the animals were pretreated with piribedil, a D2 agonist, and the other half served as controls. In control (untreated) animals, noise stimulation resulted in a progressive decrease of cochlear DA concentration. This decrease was scarcely detected when animals were pretreated with piribedil. Present findings indicate that piribedil modifies cochlear DA turnover under noise stimulation.
authors.affiliation: Departamento de Ciencias Morfológicas, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Vicente-Torres
authors.forename: P
authors.initials: P
authors.lastname: Gil-Loyzaga
authors.forename: P
authors.initials: P
authors.lastname: Fernández
authors.forename: A
authors.initials: A
authors.lastname: Arce
authors.forename: A
authors.initials: A
authors.lastname: Esquifino
mesh_terms: D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003051:Cochlea / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009622:Noise; D010891:Piribedil / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects
chemical_list: D011954:Receptors, Dopamine; D010891:Piribedil; D004298:Dopamine