Cortisol responses of depressed children and adolescents to clonidine administration.
The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to what has been observed in depressed adults. In controls, but not in patients, clonidine administration induced a transitory increase of the steroid.
Brambilla
F
F
Centro di Psiconeuroendocrinologia, Ospedale Psichiatrico Pini, Milano, Italy.
Guareschi-Cazzullo
A
A
Musetti
C
C
Nobile
P
P
Tacchini
C
C
D000293:Adolescent; D000374:Aggression / Q000187:drug effects; D002648:Child; D003000:Clonidine / Q000494:pharmacology*; D003866:Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D003000:Clonidine; D006854:Hydrocortisone