title: Autoimmune polyglandular failure associated with malabsorption and gastric carcinoid tumour.
abstract: A 21-year-old female with autoimmune polyglandular failure (APG) manifested by insulin-dependent diabetes mellitus (IDDM), hypothyroidism and pernicious anaemia developed severe malabsorption due to exocrine pancreatic insufficiency. Supplemental pancreatic enzymes resulted in marked improvement of steatorrhea. There was also an incidental finding of gastric carcinoid tumour. We identified only 13 other patients in our institution with either type 2 or 3 APG, one of which had significant steatorrhoea. Another patient with IDDM, hypothyroidism and pernicious anaemia had an asymptomatic gastric carcinoid tumour. The possible mechanisms for malabsorption in APG are discussed.
authors.affiliation: Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Leibowitz
authors.forename: G
authors.initials: G
authors.lastname: Amir
authors.forename: I S
authors.initials: IS
authors.lastname: Losses
authors.forename: R
authors.initials: R
authors.lastname: Eliakim
mesh_terms: D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications*; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000150:complications*; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications*; D013274:Stomach Neoplasms / Q000150:complications*