Chronoimmunohistochemical localization of epidermal growth factor in the submandibular gland of male rats.
Chronobiological oscillation was established for epidermal growth factor (r-EGF) in granular convoluted tubule (GCT) cells of the male rat submandibular gland (SMG) using immunohistochemistry. The high amplitude oscillation with a peak at 9 p.m. and low amplitude oscillation during the day time was noted. The distribution pattern of the r-EGF in the GCT segment was time-dependent, as it was seen at 3 p.m. when many cells with r-EGF staining were detectable. The higher reactivity during the activity phase of the rats may correlate with the intracellular biosynthesis of r-EGF required for cell proliferation and maintenance of ductal integrity. The chronobiological oscillation pattern of r-EGF seems to be important for the maintenance of ductal integrity and wound healing.
Battacharya
R D
RD
International Society for Research on Civilization Disease and Environment, Ahmedabad, India.
Sakamoto
F
F
Sumitomo
S
S
Mori
M
M
D000818:Animals; D002909:Chronobiology Phenomena; D066246:ErbB Receptors / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013363:Submandibular Gland / Q000166:cytology / Q000378:metabolism*
D066246:ErbB Receptors