Transcriptional entrainment between master-slave genes via sister chromatid exchanges.
The paper discusses a mechanism for the coordination of a differentiation path through activation of slave genes by transcriptional complexes (excitons) organised by master genes. Entrainment occurs when master-slave genes form partnerships of closely apposed entities. Sister chromatid exchanges provide the action necessary for successful entrainment. Although concerned mainly with normal hematopoietic (stem) cells, the model applies also to certain leukemic cells, regarding in particular retrodifferentiation back to the stem state followed by attenuation of malignancy.
Matioli
G T
GT
USC School of Medicine, Los Angeles 90033.
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D015870:Gene Expression; D006410:Hematopoiesis / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000473:pathology; D008957:Models, Genetic; D014411:Neoplastic Stem Cells / Q000473:pathology; D012854:Sister Chromatid Exchange; D014158:Transcription, Genetic