The influence of the muscarinic receptor subtypes on the sleep-wake cycle.
The specific role played by different muscarinic receptor subtypes in sleep regulation is investigated and discussed. On the basis of the results obtained with intracerebroventricular injections of selective muscarinic antagonists into freely moving rats, it is suggested that each muscarinic receptor subtype induces different and specific changes in sleep phases and cortical desynchronization processes.
Angeli
P
P
Dipartimento di Scienze Chimiche dell'università, Camerino (MC), Italy.
Bianchi
S
S
Imeri
L
L
Mancia
M
M
D000818:Animals; D003959:Diamines / Q000494:pharmacology; D006801:Humans; D010276:Parasympatholytics / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
D003959:Diamines; D010276:Parasympatholytics; D010880:Piperidines; D011976:Receptors, Muscarinic; C042375:4-diphenylacetoxy-1,1-dimethylpiperidinium; C054938:methoctramine