Response of aged neurons to super-hypotonic environment.
Cultured sensory neurons from aged mice (24 months old) lost capability of cell volume auto-regulatory mechanism after the rapid treatment with a hypotonic solution of 1/4 the normal osmolarity or lower. However, they could survive and extend neurites in super-hypotonic media such as 1/4 osmolar and even 1/8 osmolar culture media when the osmolarity was reduced gradually to such a low level.
Horie
H
H
Department of Physiology, Yokohama City University, School of Medicine, Japan.
Sango
K
K
Takano
M
M
Takenaka
T
T
D000375:Aging / Q000502:physiology*; D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D005727:Ganglia, Spinal / Q000166:cytology / Q000254:growth & development; D007038:Hypotonic Solutions; D051379:Mice; D008810:Mice, Inbred C57BL; D016501:Neurites / Q000502:physiology / Q000648:ultrastructure; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D009994:Osmolar Concentration
D007038:Hypotonic Solutions