Reduced parasympathetic cardiac control in patients with hypertension at rest and under mental stress.
The neurogenic component in the pathogenesis of essential hypertension has predominantly been analyzed with regard to the sympathetic part of the autonomous nervous system; the parasympathetic branch has largely been neglected. We investigated whether 54 normotensive (mean causal blood pressure [cBP]: 125 +/- 6/82 +/- 4 mm Hg), 41 borderline hypertensive (cBP: 134 +/- 8/90 +/- 5 mm Hg), and 34 hypertensive men (cBP: 152 +/- 13/101 +/- 5 mm Hg) without secondary target organ damage differed in parasympathetic cardiac control. Parasympathetic cardiac control was assessed via the amount of fast fluctuations (0.15 to 0.40 Hz; vagus band) and by the amount of respiratory-linked fluctuations (mean respiratory frequency +/- 0.03 Hz) in the power spectra of continuously registered interbeat intervals under the following conditions: mean of three rest phases with 10, 5, and 5 minutes' duration (REST); mean of two modes of a reaction time task with 10 and 5 minutes' duration (RTT); mean of 5 minutes' mental arithmetic plus noise (MA). Analysis of variance (ANOVA) shows that spectral energy in the so-called vagus band reveals the most prominent differences between blood pressure groups under all conditions: REST = normotensive, 2.70 +/- 0.31; borderline hypertensive, 2.55 +/- 0.33; and hypertensive, 2.43 +/- 0.43 (F[2.126] = 6.19; p < 0.01). RTT = normotensive, 2.41 +/- 0.35; borderline hypertensive, 2.19 +/- 0.33; and hypertensive, 2.17 +/- 0.46 (F[2.126] = 6.04; p < 0.01); MA = normotensive, 2.69 +/- 0.34; borderline hypertensive, 2.52 +/- 0.33; and hypertensive, 2.38 +/- 0.46 (F[2.126] = 7.04; p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Langewitz
W
W
Department of Psychosomatic Medicine, University Hospital Basel, Switzerland.
Rüddel
H
H
Schächinger
H
H
D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D005583:Fourier Analysis; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D013312:Stress, Physiological / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000502:physiology / Q000503:physiopathology; D014630:Vagus Nerve / Q000502:physiology / Q000503:physiopathology*