title: Enhancement of bone ingrowth into a porous hydroxylapatite-matrix using a resorbable polylactic membrane: an experimental pilot study.
abstract: The objective of this pilot study was to study bone ingrowth into porous hydroxylapatite (HA) blocks using a polylactic membrane for guided tissue regeneration. Porous HA blocks were placed on both sides of the mandible and of the ilium in five Göttingen minipigs. On one side a polylactic membrane was used to cover the blocks. After 5 months, the blocks with the membrane covering showed complete bony penetration of the HA matrix both in the mandible and the ilium. The blocks without the membrane covering showed substantially less and irregular bone ingrowth after placement on the mandible and poor ingrowth after placement on the ilium. The newly formed bone in the blocks from the ilium showed a cancellous structure while bone tissue inside the blocks from the mandible exhibited a dense cortical appearance. The polylactic membrane was nearly completely degraded at the time of investigation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, (Abt. für Mund-, Kiefer- und Gesichtschirurgie), University Medical School (Medizinische Hochschule Hannover), Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schliephake
authors.forename: F W
authors.initials: FW
authors.lastname: Neukam
authors.forename: D
authors.initials: D
authors.lastname: Hutmacher
authors.forename: J
authors.initials: J
authors.lastname: Becker
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D001861:Bone Regeneration / Q000502:physiology*; D017886:Durapatite; D005260:Female; D048091:Guided Tissue Regeneration; D007085:Ilium; D008334:Mandible; D008567:Membranes, Artificial; D010865:Pilot Projects; D011091:Polyesters; D019736:Prostheses and Implants; D013552:Swine; D013556:Swine, Miniature
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; C033616:poly(lactide); D017886:Durapatite