[The effect of a vaccinal strain of Yersinia pestis on lysosome fusion with phagosomes in peritoneal and alveolar macrophages].
It is established that the frequency of phagosome-lysosome fusion in alveolar macrophages is lower than in the peritoneal cells upon endocytosis of Yersinia pestis. The subcutaneous immunization activates the phagosome-lysosome fusion in peritoneal macrophages, whereas alveolar cells remain without change. The aerogenic vaccination stimulates this process in both peritoneal and alveolar macrophages, as distinct from subcutaneous immunization.
Vasil'eva
G I
GI
Kiseleva
A K
AK
Doroshenko
E P
EP
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008247:Lysosomes / Q000187:drug effects* / Q000276:immunology; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D010588:Phagosomes / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors; D015010:Yersinia pestis / Q000276:immunology*
D001428:Bacterial Vaccines
Vliianie vaktsinnogo shtamma chumnogo mikroba na sliianie lizosom s fagosomami v peritoneal'nykh i al'veoliarnykh makrofagakh.