title: Effects of topical mitomycin C on primary trabeculectomies and combined procedures.
abstract: The charts were reviewed of all patients who underwent primary trabeculectomies (group 1) or combined procedures (phacoemulsification + intraocular lens implantation + trabeculectomy--group 2) and received intraoperative mitomycin C (0.4 mg/ml) between 1991 and 1992 at Wills Eye Hospital. A total of 54 eyes of 54 patients were included: 39 in group 1 and 15 in group 2. Intraocular pressure was controlled successfully in 97.4% of eyes in group 1 (mean follow up 6.7 months), and in 93.3% in group 2 (mean follow up 6.8 months). Main complications included choroidal detachment (n = 15), shallow anterior chamber (n = 9), cataract formation (n = 8), and hypotony maculopathy (n = 3). The use of mitomycin C in primary trabeculectomies and combined procedures is associated with high success rates. However, it may be associated with unacceptable risks of vision threatening complications related to excessive filtration.
authors.affiliation: Wills Eye Hospital, Jeffereson Medical College, Philadelphia, PA 19107.
authors.forename: V P
authors.initials: VP
authors.lastname: Costa
authors.forename: M R
authors.initials: MR
authors.lastname: Moster
authors.forename: R P
authors.initials: RP
authors.lastname: Wilson
authors.forename: C M
authors.initials: CM
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Gandham
authors.forename: M
authors.initials: M
authors.lastname: Smith
mesh_terms: D000287:Administration, Topical; D000368:Aged; D005260:Female; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011183:Postoperative Complications; D012189:Retrospective Studies; D014130:Trabeculectomy; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D016685:Mitomycin