title: The effect of a taurine modified diet on normal and hydropic ears of the guinea pig.
abstract: Taurine is recognised as the major osmoregulating amino acid in the brain as well as other organs. Its possible influence on normal cochlear function and on hydropic cochleas of the guinea pig was investigated here. Normally hearing adult guinea pigs were placed on either a taurine-depleting diet (B-alanine) or a taurine-supplemented diet. At the end of 6 weeks the compound action potential audiograms (CAP) in the two groups were similar and appeared not to be different from a third control group receiving a non modified diet which suggested that a taurine-modified diet had not affected normal cochlear function. In hydropic ears the taurine-depleting diet was observed, in some cases, to moderately slow down the early phase of the characteristic progression of the CAP sensitivity loss. These data are in favor of a homeostatic role for taurine in the inner ear of the guinea pig under particular conditions such as osmoregulatory stress.
authors.affiliation: Inserm U229, Université Bordeaux II, Hôpital Pellegrin, France.
authors.forename: K C
authors.initials: KC
authors.lastname: Horner
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: J P
authors.initials: JP
authors.lastname: Erre
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology; D004032:Diet; D018159:Endolymphatic Hydrops / Q000178:diet therapy* / Q000209:etiology / Q000503:physiopathology; D006168:Guinea Pigs; D013654:Taurine / Q000172:deficiency / Q000494:pharmacology* / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D013654:Taurine