Alterations of inositol phosphate turnover in striatum of aged rats.
Age-related inositol phosphate turnover in the rat central nervous system was investigated. Higher phospholipase-C activity and drastically higher (almost 2.5-fold) inositol 1,4,5-trisphosphate concentration in the corpus striatum (caudate-putamen) of extremely old (approximately 40 months) female Wistar rats in comparison to the young adult (approximately 3.5 months) rats were observed. Dopamine seems to slightly inhibit total inositol phosphate formation and this effect was antagonized by (-)-sulpiride.
Sugawa
M
M
Department of Neuropsychopharmacology, Free University Berlin, FRG.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013469:Sulpiride / Q000494:pharmacology; D010738:Type C Phospholipases / Q000378:metabolism*
D013469:Sulpiride; D015544:Inositol 1,4,5-Trisphosphate; D010738:Type C Phospholipases; D004298:Dopamine