[The effect of cocaine on binding of tricyclic antidepressives in the synaptic plasma membranes in the brain].
Effect of cocaine on binding of 3H-imipramine, 3H-desmethylimipramine, 3H-didesmethylimipramine and 3H-amitriptyline to brain synaptic plasma membranes (SPM) was studied. Binding of methylated tricyclic antidepressants was more affected. Cocaine inhibits 3H-imipramine binding at concentrations higher than 10(-5) mol/l. Binding stimulated by phosphatidylserine was affected more significantly.
Bures
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P
Výzkumná psychiatrická laborator 1. LF UK, Praha.
Krulík
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R
Fisar
Z
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Fuksová
K
K
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D003042:Cocaine / Q000494:pharmacology*; D066298:In Vitro Techniques; D011955:Receptors, Drug / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
D000929:Antidepressive Agents, Tricyclic; D011955:Receptors, Drug; D003042:Cocaine
Vliv kokainu na vazbu tricyklických antidepresiv v SPM mozku.