Adenophostins A and B: potent agonists of inositol-1,4,5-trisphosphate receptor produced by Penicillium brevicompactum. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
New inositol-1,4,5-trisphosphate (InsP3) agonists, adenophostins A(1) and B(2), were isolated from the culture broth of Penicillium brevicompactum SANK 11991 and SANK 12177. Its structures were related to adenine nucleotides. The agonistic activity of adenophostins A or B for binding to the InsP3 receptor was higher than InsP3 itself.
Takahashi
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Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Kagasaki
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Hosoya
T
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Takahashi
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S
D000225:Adenine / Q000031:analogs & derivatives*; D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051379:Mice; D010407:Penicillium / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects* / Q000378:metabolism
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; C085029:adenophostin A; C085030:adenophostin B; D015544:Inositol 1,4,5-Trisphosphate; D000225:Adenine; D000241:Adenosine