Suppression of thrombin formation during hemodialysis with triglyceride.
Effect of blood-air contact in the venous line air-trap chamber on blood clotting was studied. Fourteen chronic hemodialysis patients (six men, eight women; mean age, 49 years) with elevation of thrombin-antithrombin III were studied. To prevent blood-air contact, triglyceride (NOF-005) was floated over the blood in the chamber. Control hemodialysis was performed for 4 weeks and hemodialysis using NOF-005 followed for the next 4 weeks. Clot formation in the circuit was examined after each hemodialysis and clotting factors including thrombin-antithrombin III, FXII Antigen, vWF Antigen, PF4 and beta-thromboglobulin were measured before and after the last hemodialysis of each control and NOF-005 hemodialysis. Clotting in the chamber was improved when NOF-005 was used. Thrombin-antithrombin III increase during hemodialysis was suppressed to about 30% of control values by using NOF-005. blood-air contact seems to promote thrombin generation and accelerate clot formation.
Kitamoto
Y
Y
Third Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Fukui
H
H
Matsushita
K
K
Sato
T
T
Soejima
H
H
Noguchi
Y
Y
Kasama
T
T
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000378:metabolism; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism; D006435:Renal Dialysis; D013917:Thrombin / Q000096:biosynthesis*; D014280:Triglycerides / Q000494:pharmacology*
D014280:Triglycerides; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D013917:Thrombin