[Therapy with fibrates and vitamin D metabolism].
The authors investigated in 29 patients with familial hyperlipoproteinaemia the effect of fibrate treatment (Duolip forte, Merckle, and Lipanthyl, Richter) on vitamin D metabolism. In 10 patients treated for 6 months with daily oral doses of 500 mg Duolip forte they did not prove changes of plasma levels of 25-hydroxyvitamin D, however, they recorded a rise of the 1,25-dihydroxyvitamin D3 plasma level. In 19 patients who were given for 6 months 300 mg Lipanthyl per day by the oral route they proved a significant decline of the 25-hydroxyvitamin D plasma levels and a rise of 1,25-dihydroxyvitamin D3 plasma levels. The authors maintain that fibrates influence plasma concentrations of vitamin D metabolites either directly or indirectly by reducing cholesterol plasma levels.
Wilczek
H
H
III. interní klinika 1. LF UK, Praha.
Sobra
J
J
Ceska
R
R
Justová
V
V
Procházková
R
R
Kvasilová
M
M
Jůzová
Z
Z
D000328:Adult; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D011345:Fenofibrate / Q000627:therapeutic use*; D006801:Humans; D006951:Hyperlipoproteinemias / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000378:metabolism*
D000960:Hypolipidemic Agents; D014807:Vitamin D; C028764:etofylline clofibrate; D002994:Clofibrate; D011345:Fenofibrate
Lécba fibráty a metabolismus vitaminu D.