[Effects of methyl tertiary-butyl ether on hepatic lipid peroxidation in mice].
The effect of one-shot or repeated treatment with methyl tertiary-butyl ether (MTBE) on lipid peroxidation and cytochrome P-450 in mouse liver was examined. One-shot treatment at the 500 mg/kg dose level caused a transient decrease in leukocyte number after 24 h. An increased level of lipid peroxide was observed in the liver homogenates 24 h after one-shot treatment and four weeks of repeated 200 mg/kg treatment. The hepatic cytochrome P-450 content increased after one and four weeks of repeated treatment (50, 200 mg/kg). On the other hand, the treatment did not affect glutathione content and glutathione-S-transferase activity. These results indicate that MTBE treatment caused lipid peroxidation in the liver homogenate and induction of hepatic microsomal cytochrome P-450 content.
Katoh
T
T
School of Nursing and Medical Technology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Arashidani
K
K
Kikuchi
M
M
Yoshikawa
M
M
Kodama
Y
Y
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004987:Ethers / Q000494:pharmacology*; D066298:In Vitro Techniques; D007958:Leukocyte Count / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008738:Methyl Ethers; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology
D004987:Ethers; D008738:Methyl Ethers; C043243:methyl tert-butyl ether; D003577:Cytochrome P-450 Enzyme System