Analgesic effects of antibiotics in rats.
Studies in forelimb-deafferented rats suggest that treatment with certain antibiotics can decrease pain sensation. To test this hypothesis, the analgesic effects of nine randomly selected antibiotics were studied in rats by using a constant-temperature hotplate. The results show that several antibiotics have antinociceptive properties, and two of them, chloramphenicol and ampicillin, can produce analgesia in a dose range used in human therapy (100 mg/kg). This analgesia is comparable to salicylate and ketoprofen analgesia but lower than pethidine's one. The analgesia is long lasting with chloramphenicol (10 h or more). These antinociceptive properties cannot be attributed to sedation because amphetamine-induced hyperactivity, measured in an open field, is not sensitive to injection of the most sensitive antibiotics.
Suaudeau
C
C
INSERM U 320, CHU Côte de Nacre, Caen, France.
Chait
A
A
Cimetiere
C
C
de Beaurepaire
R
R
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003714:Denervation; D003913:Dextroamphetamine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000700:Analgesics; D000900:Anti-Bacterial Agents; D003913:Dextroamphetamine