title: Changes in serum immunosuppressive acidic protein following surgery in patients with renal carcinoma.
abstract: Serum immunosuppressive acidic protein (IAP) was measured serially in 69 patients with renal carcinoma who were treated surgically and followed up for more than 6 months after surgery. Elevated IAP levels > 600 micrograms/ml were seen in 8 of 52 patients without evidence of recurrence and in 5 of 10 patients prior to clinical evidence of recurrence but in whom recurrence did eventually develop. The positive rate of IAP levels > 600 micrograms/ml in recurrent cases was significantly higher than in non-recurrent ones. In 7 patients with distant metastases, IAP levels rose to > 500 micrograms/ml in 3 of 5 patients whose disease progressed despite therapy; levels fell to < 600 micrograms/ml in 2 patients who responded to therapy. The data suggest that recurrence should be suspected in patients with IAP levels > 600 micrograms/ml, as these changes appear to correlate with the response of metastases to therapy.
authors.affiliation: Department of Urology, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Yasumasu
authors.forename: J
authors.initials: J
authors.lastname: Uozumi
authors.forename: S
authors.initials: S
authors.lastname: Naito
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D009364:Neoplasm Recurrence, Local / Q000097:blood; D011184:Postoperative Period
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein