title: [Antimicrobial activities of polymyxin B against clinically isolated microbial strains. Results of MIC determination including high concentrations].
abstract: Minimum inhibitory concentrations (MICs) were determined for polymyxin B (PL-B), gentamicin, ofloxacin and norfloxacin against clinically isolated microbial strains collected since November 1992, and the following conclusions were obtained: 1. Judging from the MIC distribution of PL-B against the studied strains including multi-drug resistant organisms of major strains of family Enterobacteriaceae, such as Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., and Pseudomonas aeruginosa, it appeared that no PL-B resistant strains were detected among those Gram-negative organisms within the antimicrobial spectrum of PL-B. 2. MICs of PL-B against most strains including methicillin resistant Staphylococcus aureus and coagulase-negative staphylococci were distributed between 100 and 800 micrograms/ml. These results supported reports of other investigators that the eradication of Staphylococcus spp. including MRSA (methicillin-resistant S. aureus) was possible by the use of PL-B at 1 mg/ml. 3. MIC distribution of PL-B against organisms of the Bacteroides fragilis group was almost the same as the results described above.
authors.affiliation: Section of Studies, Tokyo Clinical Research Center.
authors.forename: K
authors.initials: K
authors.lastname: Deguchi
authors.forename: N
authors.initials: N
authors.lastname: Yokota
authors.forename: M
authors.initials: M
authors.lastname: Koguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Fukayama
authors.forename: R
authors.initials: R
authors.lastname: Ishihara
authors.forename: S
authors.initials: S
authors.lastname: Oda
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Nakane
authors.forename: T
authors.initials: T
authors.lastname: Fukumoto
mesh_terms: D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001441:Bacteroides fragilis / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D011112:Polymyxin B