Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells.
Chromone, flavone and xanthone analogues of geiparvarin (1) are described. Compounds 2a and 2b are more active in inhibiting the proliferation of F10 metastatic murine melanoma cells. In particular, 2a is 13 times more active at microM concentration after 48 h exposure.
Valenti
P
P
Department of Pharmaceutical Sciences, University of Bologna, Italy.
Da Re
P
P
Rampa
A
A
Montanari
P
P
Carrara
M
M
Cima
L
L
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002867:Chromones / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008855:Microscopy, Electron, Scanning; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014966:Xanthenes / Q000737:chemistry; D044004:Xanthones
D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones; D003374:Coumarins; D047309:Flavones; D005419:Flavonoids; D014966:Xanthenes; D044004:Xanthones; C009689:xanthone; C058446:geiparvarin; C043562:flavone