Blood styrene concentrations in a "normal" population and in exposed workers 16 hours after the end of the workshift.
Blood styrene was measured by a gas chromatography-mass spectrometry method in 81 "normal people" and in 76 workers exposed to styrene. In the normal subjects, styrene was also tested in alveolar and environmental air. Styrene was found in nearly all (95%) blood samples. Average styrene levels in the normal subjects were 221 ng/l in blood (Cb), 3 ng/l in alveolar air (Ca) and 6 ng/l in environmental air (Ci). Styrene levels did not differ significantly between smokers and nonsmokers, 95% of values being below 512 ng/l in Cb, 7 ng/l in Ca and 15 ng/l in Ci. In workers with an average exposure to styrene of 204 micrograms/l, at the end of the workshift, mean blood styrene concentration was 1211 micrograms/l. In blood samples collected at the end of the Thursday shift, styrene levels were significantly higher (1590 micrograms/l) than those found at the end of the Monday shift (1068 micrograms/l). A similar difference was found in samples taken the morning after exposure (60 and 119 micrograms/l, respectively). Significant correlations between blood and environmental styrene were found both at the end of the shift and the morning after exposure (r = 0.61 and 0.41, respectively). In workers occupationally exposed to styrene, 16 h after the end of the workshift, blood styrene (94 micrograms/l) was significantly higher than that found in the normal subjects (0.22 microgram/l). The half-life of blood styrene was 3.9 h.
Brugnone
F
F
Institute of Occupational Medicine, University of Verona, Policlinico Borgo Roma, Italy.
Perbellini
L
L
Wang
G Z
GZ
Maranelli
G
G
Raineri
E
E
De Rosa
E
E
Saletti
C
C
Soave
C
C
Romeo
L
L
D000328:Adult; D001944:Breath Tests; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012016:Reference Values; D020058:Styrene; D013343:Styrenes / Q000493:pharmacokinetics*
D013343:Styrenes; D020058:Styrene