Changes in lipid, peroxide, and anti-oxidant blood levels during piroxicam (Hotemin) treatment.
The authors examined the lipid-peroxide (malondialdehyde) blood concentration of patients suffering from rheumatoid arthritis of osteoarthrosis. Of the anti-oxidant compounds, they examined the vitamin E concentration of blood plasma and catalase as well as glutathione-peroxidase enzyme activities. They also measured the oxidation capacity of blood plasma. It has been observed that the functional condition of patients in both disease groups improved following a 14-day treatment (20 md/day Hotemin). The degree of lipid-peroxidation (malondialdehyde content) as well as plasma oxidation capacity decreased in patients with osteoarthrosis, while these values did not change in patients suffering from rheumatoid arthritis. When examining the anti-oxidant enzymes in rheumatoid arthritis, a significant change was observed in glutathione-peroxidase activity. On the basis of the results it may be concluded that piroxicam has no direct anti-inflammatory action, but as an anti-oxidant, it exerts an action which is disease specific.
Bartosiewicz
G
G
Department of Rheumatology, MAV Hospital.
Mézes
M
M
Német
J
J
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D002374:Catalase / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D010894:Piroxicam / Q000494:pharmacology / Q000627:therapeutic use*; D014810:Vitamin E / Q000097:blood*
D010894:Piroxicam; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase