title: [A cancer marker study in patients with neoplastic pathology of the neck and head area].
abstract: Specific markers able to detect either the presence of tumours or to identify the histological type of tumour are not currently available. Previous work yields an inconsistent picture of actual effectiveness of oncological markers, we therefore carried out a study on the cancer patients in our clinic. The present paper considered five markers (CEA, SCC, ca 19-9, TPA and Ferritin) and tested their effectiveness in diagnosing and following patients with head and neck neoplasias. The study was carried out on 102 patients, divided into three groups: 59 had been histologically diagnosed cancer but had not received any treatment (first group), the remaining 43 who had been treated (second group). We have also monitored the first group of no treated patients six months after therapy (third group). Our results suggest that while no significant conclusions may be drawn from SCC and CA 19-9, we found interesting results concerning Ferritin. Indeed Ferritin values increased by 22% in the first group, by 26% in the second one and by 19% in the third one. CEA and TPA values increased in non treated patients only by 22% and 12% respectively while they did not alter in the treated ones and they altered by 10.5% and by 10% respectively six months after therapy. Although our data are still preliminary and speculative and further evidence is needed, we can infer that the stage of the cancer and the positive markers appear to be concluded. The correlation is even stronger when all the cases are considered, without introducing the statistical and epidemiological variables.
authors.affiliation: I Clinica ORL, Università di Torino.
authors.forename: C
authors.initials: C
authors.lastname: Giordano
authors.forename: G
authors.initials: G
authors.lastname: Spiga
authors.forename: B
authors.initials: B
authors.lastname: Fedrighini
authors.forename: A
authors.initials: A
authors.lastname: Pagliassotto
authors.forename: A
authors.initials: A
authors.lastname: Piovano
authors.forename: F
authors.initials: F
authors.lastname: Pecchio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Studio di markers oncologici in pazienti con patologia neoplastica del distretto cervico-cefalico.