Ciliary neurotrophic factor as an injury factor.
This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting. The functional relevance of ciliary neurotrophic factor in non-injury situations is also evaluated, with emphasis on its possible roles in embryonic development.
Adler
R
R
Retinal Degenerations Research Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
D000818:Animals; D016922:Cellular Senescence / Q000502:physiology; D020934:Ciliary Neurotrophic Factor; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D020196:Trauma, Nervous System; D014947:Wounds and Injuries / Q000378:metabolism*
D020934:Ciliary Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins