title: The effects of venous blood, silicone gel and prilocaine on capsular contraction around silicone implants studied with a new method in the rat.
abstract: The pressure exerted by wound tissue on a subcutaneously implanted silicone expander was studied in rats. A significant increase in pressure was noted four and eight weeks postoperatively when venous blood was instilled into the cavity around the expander, but this increase was significantly reduced at eight weeks if 1.0 ml of prilocaine 5 mg/ml with adrenaline 4 micrograms/ml was instilled at the same time as the blood. Instillation of silicone gel outside the expander tended to increase the pressure eight weeks postoperatively, but there was no increase when silicone gel was given together with prilocaine and adrenaline. The next step is to investigate whether prilocaine with adrenaline instilled around an implanted mammary prosthesis in humans is not only capable of reducing pain and bleeding but can also inhibit capsular contracture.
authors.affiliation: Department of Preclinical Research, Astra Pain Control AB, Södertälje, Sweden.
authors.forename: L O
authors.initials: LO
authors.lastname: Pettersson
authors.forename: B
authors.initials: B
authors.lastname: Akerman
mesh_terms: D000818:Animals; D001790:Blood Physiological Phenomena; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005782:Gels; D008297:Male; D016462:Mammaplasty / Q000295:instrumentation; D011312:Pressure; D011318:Prilocaine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012828:Silicones / Q000494:pharmacology*; D015625:Tissue Expansion Devices; D014680:Veins
chemical_list: D005782:Gels; D012828:Silicones; D011318:Prilocaine; D004837:Epinephrine