title: [The effect of cocaine on binding of tricyclic antidepressives in the synaptic plasma membranes in the brain].
abstract: Effect of cocaine on binding of 3H-imipramine, 3H-desmethylimipramine, 3H-didesmethylimipramine and 3H-amitriptyline to brain synaptic plasma membranes (SPM) was studied. Binding of methylated tricyclic antidepressants was more affected. Cocaine inhibits 3H-imipramine binding at concentrations higher than 10(-5) mol/l. Binding stimulated by phosphatidylserine was affected more significantly.
authors.affiliation: Výzkumná psychiatrická laborator 1. LF UK, Praha.
authors.forename: P
authors.initials: P
authors.lastname: Bures
authors.forename: R
authors.initials: R
authors.lastname: Krulík
authors.forename: Z
authors.initials: Z
authors.lastname: Fisar
authors.forename: K
authors.initials: K
authors.lastname: Fuksová
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D003042:Cocaine / Q000494:pharmacology*; D066298:In Vitro Techniques; D011955:Receptors, Drug / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D011955:Receptors, Drug; D003042:Cocaine
vernacular_title: Vliv kokainu na vazbu tricyklických antidepresiv v SPM mozku.