[Pituitary resistance to thyroid hormone].
Thyroid hormone resistance syndromes are characterized by unresponsiveness of target tissues to thyroid hormone and include a group of three disorders: generalized resistance, selective pituitary resistance and peripheral resistance. These patients are identified because they have persistently increased serum thyroxin (T4), triiodothyronine (T3) and normal or elevated thyrotropin levels. In case of selective pituitary resistance to thyroid hormone (PRTH), the peripheral tissues exhibit a normal response to T4 and T3 so that hyperthyroidism ensues. Recently cloning of T3 receptor has allowed detection of mutations in the T3 binding region of the T3 receptor gene, which provides strong evidence that P.R.T.H. represents part of the spectrum of generalized resistance to T3, rather than a separate entity.
Ashizawa
K
K
First Department of Internal Medicine, Nagasaki University School of Medicine.
Nagataki
S
S
D000293:Adolescent; D004351:Drug Resistance / Q000502:physiology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood; D010900:Pituitary Diseases / Q000097:blood / Q000503:physiopathology*; D010902:Pituitary Gland / Q000503:physiopathology*; D011988:Receptors, Thyroid Hormone / Q000235:genetics; D013963:Thyroid Hormones / Q000097:blood*
D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones