title: Anticoccidial efficacy of semduramicin. 1. Evaluation against field isolates by dose titration in battery tests.
abstract: Semduramicin (AVIAX), a novel polyether ionophore, was titrated in a series of five battery tests at 20, 25, and 30 ppm in feed to determine the optimum level for use. Twelve-day-old broiler chicks were medicated for 48 h prior to inoculation in each 9-day test. The inocula included monospecific field isolates of Eimeria tenella, Eimeria brunetti, Eimeria necatrix, and Eimeria maxima, and a mixture of these species with Eimeria acervulina and Eimeria mitis. The numbers of oocysts inoculated were selected after titration of each species and the mixture of species. All three concentrations of semduramicin significantly (P < .05) reduced coccidiosis mortality and lesion scores and achieved lower feed:gain ratios and greater weight gains than the infected, unmediated treatments. A concentration of 25 ppm semduramicin was determined to be optimal based on improved lesion control compared with 20 ppm and improved weight gain compared with 30 ppm.
authors.affiliation: Central Research Division, Pfizer Inc., Terre Haute, Indiana 47808.
authors.forename: M E
authors.initials: ME
authors.lastname: McKenzie
authors.forename: D P
authors.initials: DP
authors.lastname: Conway
authors.forename: N B
authors.initials: NB
authors.lastname: Logan
authors.forename: C P
authors.initials: CP
authors.lastname: Wilkins
authors.forename: L R
authors.initials: LR
authors.lastname: Chappel
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D004539:Eimeria; D009550:Nigericin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D013045:Species Specificity; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; C072941:semduramicin; D009550:Nigericin