title: Effect of long-term aerobic exercise on helium-neon-laser-induced thrombogenesis in rat mesenteric arterioles and platelet aggregation.
abstract: We have previously investigated the antithrombotic effect of aerobic exercise in rat arterioles and venules under conditions of variable exercise load. In the present study, rats were subjected to constant exercise of 90% maximal oxygen uptake for 30 min, 5 times a week for 2, 4, 8 or 18 weeks. Thrombotic tendency was assessed by the He-Ne-laser-induced thrombus formation method. Platelet aggregation, platelet adhesion, whole blood clotting time, fibrinogen levels and blood cell count were also measured. The thrombotic tendency in arterioles decreased significantly after 18 weeks training, but not in venules. Thrombotic tendency increased slightly after 2 weeks training though the differences were not significant. A significant decrease in collagen-induced platelet aggregation was observed after 18 weeks training. The results demonstrated that long-term aerobic training decreased the thrombotic tendency in rat arterioles and that this was partly due to decreased platelet aggregability.
authors.affiliation: Laboratory of Physiology, Faculty of Nutrition, Kobe-Gakuin University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Yamamoto
authors.forename: I
authors.initials: I
authors.lastname: Ishii
authors.forename: A
authors.initials: A
authors.lastname: Chikamori
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Nagamatsu
authors.forename: S
authors.initials: S
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Tsukahara
mesh_terms: D000818:Animals; D001160:Arterioles; D001772:Blood Cell Count; D006371:Helium; D007834:Lasers; D008297:Male; D009356:Neon; D010101:Oxygen Consumption / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000379:methods; D010973:Platelet Adhesiveness / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013152:Splanchnic Circulation / Q000502:physiology*; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D006371:Helium; D009356:Neon