title: [HLA A, B, C and DR antigens in a urban population from Santiago of Chile].
abstract: HLA antigens vary in different ethnical groups and in Chile there are no reports on the frequency of these antigens in a normal representative population. The few existing studies are of indigenous populations and control groups, without including HLA-DR antigens. Therefore, the aim of this study was to study the frequency of HLA A, B and C antigens in 349 individuals and HLA-DR in 257, using the microlymphocytotoxicity method, and compared the results with those on normal caucasian populations (Europe and USA). Significant differences were found for 7 antigens of group A, 10 of group B, 4 of group C and 6 of group DR. The observed difference allow us to conclude that the population from Santiago has a distinct HLA antigen distribution. This fact must be bore in mind future studies in genetics, paternity or autoimmune diseases.
authors.affiliation: Unidad Docente Asociada de Laboratorio Clínico, Escuela de Medicina, P Universidad Católica de Chile, Santiago de Chile.
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez
authors.forename: P
authors.initials: P
authors.lastname: Scagliotti
authors.forename: T
authors.initials: T
authors.lastname: Quiroga
mesh_terms: D000328:Adult; D002677:Chile; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics; D015236:HLA-C Antigens / Q000032:analysis / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D008297:Male; D014505:Urban Population; D044465:White People
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens
vernacular_title: Antígenos HLA-A, B, C y DR en una población urbana de Santiago de Chile.