Synthesis of some 1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium antagonistic activity.
Twenty-seven new 2-methyl-3-acetyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives have been prepared. Their structures were confirmed by UV, IR, 1H-NMR and elementary analysis. The calcium antagonistic activity of these compounds was tested in K(+)-depolarized taenia coli precontracted with 1 mmol/l Ca+2.
Safak
C
C
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Erdemli
I
I
Sunal
R
R
D000818:Animals; D002121:Calcium Channel Blockers / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D003106:Colon / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006873:Hydroquinones / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D002121:Calcium Channel Blockers; D006873:Hydroquinones