Studies of vanadyl sulfate as a glucose-lowering agent in STZ-diabetic rats.
To study the effect of vanadium (V) intake on blood glucose lowering, tissue V concentrations, glutathione reductase (GR) activity, and plasma trace metal concentrations, streptozotocin(STZ)-diabetic rats were treated with vanadyl sulfate (VS) (0.5-1.2 g/l in the drinking water) for up to 12 weeks. Kidney and plasma V concentrations were positively correlated with V intake. Kidney GR activities were not affected by VS treatment nor were plasma cobalt, molybdenum, manganese or lithium concentrations. Individual V intakes were dependent upon severity of diabetes, with more hyperglycemic rats consuming greater quantities of VS solution. A diminished effect on glucose lowering of VS above 1 g/l was noted.
Thompson
K H
KH
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Leichter
J
J
McNeill
J H
JH
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D002149:Energy Intake; D005980:Glutathione Reductase / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014639:Vanadium / Q000097:blood / Q000378:metabolism; D017968:Vanadium Compounds / Q000627:therapeutic use*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D017968:Vanadium Compounds; D014639:Vanadium; C034028:vanadyl sulfate; D005980:Glutathione Reductase