Absence of typical Nippostrongylus brasiliensis self-cure in putative BALB/c mice.
Rejection of Nippostrongylus brasiliensis in mice typically occurs by 14 days postinfection (PI). We report here on a putative BALB/c mouse strain from the University of Texas at El Paso (UTEP) animal colony that did not exhibit a normal pattern of self-cure. Following subcutaneous inoculation with approximately 500 third-stage larvae of N. brasiliensis, the parasite was present in substantial numbers in UTEP BALB/c mice on days 21 and 28 PI and in low numbers through day 70 PI regardless of host sex. Normal self-cure was observed using identical techniques in 2 other BALB/c strains and a CFW strain. Hence, the UTEP BALB/c mouse provides a unique tool to examine the immune response to N. brasiliensis.
Mayberry
L F
LF
Department of Biological Sciences, University of Texas at El Paso 79968-0519.
Conder
G A
GA
Bristol
J R
JR
Johnson
S S
SS
Modric
S
S
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000469:parasitology*; D008815:Mice, Inbred Strains; D009559:Nippostrongylus / Q000276:immunology*; D012376:Rodent Diseases / Q000276:immunology*; D012737:Sex Factors; D017206:Strongylida Infections / Q000276:immunology / Q000662:veterinary*