title: [Thyroid profile in normal pregnancy].
abstract: The aim of this study was to update the thyroid hormone profile in normal pregnant women with adequate iodine nutrition, to analyze the physiological changes that occur during pregnancy and to know the role that TBG and bHCG exert on these changes. One hundred six pregnant women without goiter, former thyroid diseases or positive antimicrosomal antibodies were studied. Fifty three of them were prospectively followed during the gestational period. Thirty age matched non pregnant women were studied as a control group. Serum T3t, T4t, T41, conventional and IRMA TSH, rT3, TBG, bHCG, antimicrosomal antibodies and urinary iodine content were measured. Median urinary iodine content was 18.9 ug/ml in pregnant women, discarding iodine deficiency, the main observed changes occurred between weeks 6 and 14 with significant elevations of T3t, T4t, T41, rT3, TBG and bHCG and TSH decrease. There was a positive correlation between TBG and T3t and T4t indicating a causal relationship. There was a negative correlation between T41 and TSH and between TSH and bHCG and a positive correlation between T41 and bHCG, suggesting a thyroid stimulator effect of bHCG which would raise T41 and thus inhibit TSH secretion.
authors.affiliation: Depto de Medicina, Facultad de Medicina, Universidad de Chile, Santiago de Chile.
authors.forename: N
authors.initials: N
authors.lastname: Wohllk
authors.forename: M
authors.initials: M
authors.lastname: Osorio
authors.forename: J
authors.initials: J
authors.lastname: Aguayo
authors.forename: G
authors.initials: G
authors.lastname: Pineda
authors.forename: V
authors.initials: V
authors.lastname: Miranda
authors.forename: H
authors.initials: H
authors.lastname: Norambuena
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007455:Iodine / Q000652:urine; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D013963:Thyroid Hormones; D007455:Iodine
vernacular_title: Perfil tiroideo de la embarazada normal.