title: Chronoimmunohistochemical localization of epidermal growth factor in the submandibular gland of male rats.
abstract: Chronobiological oscillation was established for epidermal growth factor (r-EGF) in granular convoluted tubule (GCT) cells of the male rat submandibular gland (SMG) using immunohistochemistry. The high amplitude oscillation with a peak at 9 p.m. and low amplitude oscillation during the day time was noted. The distribution pattern of the r-EGF in the GCT segment was time-dependent, as it was seen at 3 p.m. when many cells with r-EGF staining were detectable. The higher reactivity during the activity phase of the rats may correlate with the intracellular biosynthesis of r-EGF required for cell proliferation and maintenance of ductal integrity. The chronobiological oscillation pattern of r-EGF seems to be important for the maintenance of ductal integrity and wound healing.
authors.affiliation: International Society for Research on Civilization Disease and Environment, Ahmedabad, India.
authors.forename: R D
authors.initials: RD
authors.lastname: Battacharya
authors.forename: F
authors.initials: F
authors.lastname: Sakamoto
authors.forename: S
authors.initials: S
authors.lastname: Sumitomo
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000818:Animals; D002909:Chronobiology Phenomena; D066246:ErbB Receptors / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013363:Submandibular Gland / Q000166:cytology / Q000378:metabolism*
chemical_list: D066246:ErbB Receptors