Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo.
Murine peritoneal macrophages were preincubated with amphotericin B (AMPH) and were then stimulated with bacterial lipopolysaccharide or streptococcal preparation (OK432). These macrophages produced a large amount of tumor necrosis factor. When administered to mice, the priming activity of amphotericin B for tumor necrosis factor production in vivo was also observed.
Tokuda
Y
Y
Department of Microbiology and Immunology, School of Medicine, Teikyo University, Tokyo, Japan.
Tsuji
M
M
Yamazaki
M
M
Kimura
S
S
Abe
S
S
Yamaguchi
H
H
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D000666:Amphotericin B