title: Acetylator polymorphism in rheumatoid arthritis.
abstract: Acetylator phenotype has been determined with sulphamethazine (sulphadimidine) in 69 Spanish patients with rheumatoid arthritis (48 females), all of whom were on second line therapy, and in 96 age-matched normal controls (54 females). Thirty-two patients (46.4%) and 56 controls (58.3%) were classified as slow acetylators. On analysing separately the females in both groups, 37.5% of patients and 63% of controls were found to be slow acetylators. No difference was found in the males (patients 66.3% and controls 52.4% slow acetylators). Rapid acetylator phenotype may be a risk factor for the development of severe rheumatoid arthritis in women.
authors.affiliation: Department of Medicine, Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Ladero
authors.forename: M P
authors.initials: MP
authors.lastname: Andres
authors.forename: A
authors.initials: A
authors.lastname: Bañares
authors.forename: B
authors.initials: B
authors.lastname: Fernández
authors.forename: C
authors.initials: C
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Benítez
mesh_terms: D000107:Acetylation; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013030:Spain; D013418:Sulfamethazine / Q000378:metabolism*
chemical_list: D013418:Sulfamethazine