Aberrant CD8 antigen expression in a patient with B chronic lymphocytic leukaemia showing unusual disease progression.
Co-expression of T cell antigens in B-CLL has been well recognized. The commonest T cell antigen known to be expressed in B-CLL is CD5, and recent reports suggest that CD5 expression is associated with good prognosis. Expression of CD8 antigen, however, is much less common with uncertain prognostic significance. We report a case of B-CLL with aberrant CD8 expression, who had unusual disease progression with a fatal outcome.
Ghosh
K
K
Department of Hameatology, Leicester Royal Infirmary.
Sivakumaran
M
M
Wood
J K
JK
D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D016827:CD8 Antigens / Q000097:blood*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008297:Male; D011379:Prognosis
D000951:Antigens, Neoplasm; D016827:CD8 Antigens