title: Gingival crevicular fluid IL-8: correlation with local IL-1 beta levels and patient estrogen status.
abstract: Gingival crevicular fluid (GCF) IL-8 and IL-1 beta levels were determined by sandwich enzyme-linked immunosorbent assays. Associations between IL-8 and IL-1 beta GCF levels, and between these cytokines and patient estrogen status were evaluated. IL-8 and IL-1 beta were detected more frequently and in higher amounts/30 s GCF sample in estrogen-deficient patients than in estrogen-sufficient patients. IL-8 and IL-1 beta GCF levels were significantly correlated. These findings suggest that GCF IL-8 levels are associated with patient estrogen status and local IL-1 beta concentrations.
authors.affiliation: Department of Surgical Specialties, University of Nebraska Medical Center, College of Dentistry, Lincoln 68583-0740.
authors.forename: J B
authors.initials: JB
authors.lastname: Payne
authors.forename: R A
authors.initials: RA
authors.lastname: Reinhardt
authors.forename: M P
authors.initials: MP
authors.lastname: Masada
authors.forename: L M
authors.initials: LM
authors.lastname: DuBois
authors.forename: A C
authors.initials: AC
authors.lastname: Allison
mesh_terms: D000328:Adult; D000367:Age Factors; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D004967:Estrogens / Q000172:deficiency* / Q000378:metabolism; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism*; D016014:Linear Models; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000378:metabolism; D010518:Periodontitis / Q000378:metabolism*
chemical_list: D004967:Estrogens; D007375:Interleukin-1; D016209:Interleukin-8