Mammary tumour induction by pituitary grafting in male mice: an animal model for male breast cancer.
Isologous anterior pituitary grafting, 4 each, to 3-4-month-old SHN and SLN male mice resulted in an appearance of mammary tumours from 8 months of age and the incidence at 12 months reached 53.8% in each strain. All tumours were diagnosed as type B adenocarcinomas. In association with the results, normal mammary gland growth and mouse mammary tumour virus (MMTV)-gp52 antigen levels in the submaxillary glands were stimulated by the treatment in these strains. The effect of pituitary grafting was much less in GR/A male mice in which no mammary tumours appeared.
Nagasawa
H
H
Experimental Animal Research Laboratory, Meiji University, Kawasaki, Japan.
Morii
S
S
Furuichi
R
R
Iwai
Y
Y
Iwai
M
M
Mori
T
T
Goto
Y
Y
D000230:Adenocarcinoma / Q000209:etiology; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D008321:Mammary Glands, Animal / Q000254:growth & development; D008325:Mammary Neoplasms, Experimental / Q000209:etiology*; D008324:Mammary Tumor Virus, Mouse / Q000302:isolation & purification; D051379:Mice; D010903:Pituitary Gland, Anterior / Q000637:transplantation*; D011388:Prolactin / Q000502:physiology; D013363:Submandibular Gland / Q000382:microbiology
D011388:Prolactin