The molecular and genetic dissection of the retinoid signalling pathway.
Retinoids are derivatives of vitamin A (retinol) that exert a wide variety of profound effects on vertebrate development, cellular differentiation and homeostasis. How these simple molecules can exert such pleiotropic effects has recently been an area of intensive investigation. A complex array of combinatorial effects is beginning to emerge from molecular and genetic studies, which may ultimately account for the pleiotropic effects of retinoids.
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Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
D000818:Animals; D006801:Humans; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism; D012176:Retinoids / Q000494:pharmacology*; D015398:Signal Transduction
D018168:Receptors, Retinoic Acid; D012176:Retinoids