title: HLA supratypes in an Italian population.
abstract: A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasoid populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.
authors.affiliation: Department of Genetics, Biology, and Medical Chemistry, Torino University, Italy.
authors.forename: S
authors.initials: S
authors.lastname: D'Alfonso
authors.forename: N
authors.initials: N
authors.lastname: Cappello
authors.forename: I
authors.initials: I
authors.lastname: Borelli
authors.forename: G
authors.initials: G
authors.lastname: Mazzola
authors.forename: D
authors.initials: D
authors.lastname: Peruccio
authors.forename: M
authors.initials: M
authors.lastname: Giordano
authors.forename: I
authors.initials: I
authors.lastname: Cascino
authors.forename: R
authors.initials: R
authors.lastname: Tosi
authors.forename: P M
authors.initials: PM
authors.lastname: Richiardi
mesh_terms: D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006682:HLA-DP Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007558:Italy; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens