title: Spectral localization of arbitrarily shaped regions of interest (SLASH) using single voxel signals.
abstract: A method for obtaining localized spectra from arbitrarily shaped regions of interest is described. When a sample consists of homogeneous compartments or domains, spectra localized in each compartment can be obtained from signals of single voxels with regular shapes by solving a set of simultaneous linear equations. Experimental demonstrations on a phantom and on human brain in vivo for a two compartment, two voxel case are presented. The issue of signal-to-noise ratio is also discussed.
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia 19104.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Reddy
authors.forename: J C
authors.initials: JC
authors.lastname: Haselgrove
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Goelman
authors.forename: R A
authors.initials: RA
authors.lastname: Zimmerman
authors.forename: J S
authors.initials: JS
authors.lastname: Leigh
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008961:Models, Structural