[Screening test of crude drug extract on anti-HIV activity].
The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 micrograms/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.
Yamasaki
K
K
Osaka Prefectural Institute of Public Health, Japan.
Otake
T
T
Mori
H
H
Morimoto
M
M
Ueba
N
N
Kurokawa
Y
Y
Shiota
K
K
Yuge
T
T
D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D013601:T-Lymphocytes; D014779:Virus Replication / Q000187:drug effects
D004365:Drugs, Chinese Herbal