[Effects of Salvia miltiorrhizae compositae on phosphoinositides metabolism in acute myocardial ischemia].
The effects of Salvia miltiorrhizae compositae (SMC) on phosphoinositides metabolism of acute myocardial ischemia in rats were studied. The results showed that the function of the phosphoinositide signaling system was enhanced 10 min. after acute myocardial ischemia. Both of the accumulations of phosphatidylinositol-4,5-biphosphate (PIP2) and inositol-1,4,5-triphosphate (IP3) were higher than those of the non-ischemic control group (P < 0.01, n = 7). The rise of the levels of PIP2 and IP3 caused by acute myocardial ischemia was remarkably inhibited by the SMC (2g/kg body wt.), and the levels of PIP2 and IP3 were lower than those of the ischemic group (P < 0.01, n = 7).
Tao
Y Y
YY
Navy No. 414 Hospital, Nanjing.
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010936:Plant Extracts; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010936:Plant Extracts; D015544:Inositol 1,4,5-Trisphosphate