title: Metal complexes of anti-inflammatory drugs. Part VIII: Suprofen complex of copper(II).
abstract: The preparation and properties of the copper(II) complex Cu(SUP)2.H2O are reported for the anti-inflammatory drug Suprofen (SUP). The diffuse reflectance spectra and magnetic moment are consistent with a dinuclear structure as found for [Cu(aspirinate)2(H2O)]2. The copper(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.
authors.affiliation: Department of Chemistry, University College of North Wales, Bangor, Gwynedd, United Kingdom.
authors.forename: A E
authors.initials: AE
authors.lastname: Underhill
authors.forename: S A
authors.initials: SA
authors.lastname: Bougourd
authors.forename: M L
authors.initials: ML
authors.lastname: Flugge
authors.forename: S E
authors.initials: SE
authors.lastname: Gale
authors.forename: P S
authors.initials: PS
authors.lastname: Gomm
mesh_terms: D003300:Copper / Q000737:chemistry*; D016166:Free Radical Scavengers; D008961:Models, Structural; D009942:Organometallic Compounds / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides; D013496:Suprofen / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D009942:Organometallic Compounds; C084744:suprofen-copper(II) complex; D013481:Superoxides; D003300:Copper; D013496:Suprofen; D013482:Superoxide Dismutase