[Pancreas penetration by ofloxacin--a pilot study].
The use of antibiotics in patients with necrotizing pancreatitis is indicated since bacterial complications are the most common cause of death in this condition. Olfloxacin was studied in six patients regarding its permeation into pancreatic juice and bile and into pancreatic tissue in cases of chronic pancreatitis and pancreatic carcinoma. The peak concentrations in pancreatic juice (3.7 mg/l) and bile (12.9 mg/l) were found 20 minutes after i.v. administration of 3 mg/kg ofloxacin, these are 79 and 275% of the corresponding serum level, respectively. Pancreatic tissue concentrations varied between 54 and 333% of serum values in relation to the removal time of specimens and to the stage of inflammation. After three days and five days of ofloxacin treatment with doses of 2 x 200 mg daily even in pancreatic necroses concentrations were detected between 0.8 and 3.7 mg/kg wet weight. This suggests that in all pancreatic compartments analyzed, sufficient antibacterial ofloxacin levels above the MIC of relevant germs were found. Therefore, from a pharmacokinetic point of view, ofloxacin could be a potentially effective drug in prophylaxis and therapy of bacterial infections of the pancreas.
Koch
K
K
Chirurgische Universitätsklinik, Medizinischen Fakultät, Universität Rostock.
Drewelow
B
B
Brinckmann
W
W
D002288:Adenocarcinoma, Mucinous / Q000097:blood* / Q000601:surgery; D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism; D001651:Cholestasis, Extrahepatic / Q000097:blood / Q000601:surgery; D002908:Chronic Disease; D004379:Duodenal Neoplasms / Q000097:blood* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010179:Pancreas / Q000378:metabolism* / Q000601:surgery; D010189:Pancreatic Juice / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000601:surgery; D010195:Pancreatitis / Q000097:blood* / Q000601:surgery; D010865:Pilot Projects; D011292:Premedication
D015242:Ofloxacin
Die Pankreaspenetration von Ofloxacin--Eine Pilotstudie.