N E. coli, inducible DNA repair is error-prone with regard to lethality.
The umuC gene is a member of the inducible SOS repair network in E. coli. The experiments reported here indicate that the product of the umuC locus can make lethal mistakes during its normal repair function. Such "lethal repair" may be a major factor in establishing a cell's sensitivity to radiation.
Ewing
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Department of Radiation Oncology & Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102.
D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000528:radiation effects; D005798:Genes, Bacterial; D005804:Genes, Lethal; D005990:Glycerol / Q000378:metabolism / Q000494:pharmacology; D013014:SOS Response, Genetics / Q000235:genetics*; D014965:X-Rays
D005990:Glycerol