Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination.
Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was elucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chemical analyses of dephostatin and its derivatives.
Kakeya
H
H
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Imoto
M
M
Takahashi
Y
Y
Naganawa
H
H
Takeuchi
T
T
Umezawa
K
K
D000107:Acetylation; D006865:Hydrogenation; D006873:Hydroquinones / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D013302:Streptomyces / Q000737:chemistry*
D006873:Hydroquinones; C084037:dephostatin; D017027:Protein Tyrosine Phosphatases