[Dyslipidemic patients with coronary cardiopathy. Effect of different doses of OMEGA-3 fatty acids on serum lipids and lipoproteins].
Twenty one male patients aged 35 to 70 years, with coronary artery disease and dislipidemia refractory to dietary treatment, were assigned to three parallel groups of 7 individuals each that received a supplemental dose of 2, 4 and 6 g/day of omega-3 fatty acids during 60 days. After a 30 days wash-out period and 60 of supplementation, subjects were weighed, a dietary survey was performed, serum levels of total cholesterol and triglycerides, the lipid content of serum lipoproteins and the content of EPA+DHA in plasma phospholipids were measured. A dose dependent increase in EPA+DHA content of phospholipids and no changes in weight or nutrient intake were observed during the supplementation period. With the 6 g dose, a significant reduction in total cholesterol, with a reduction in VLDL and increase in LDL cholesterol and a decline in VLDL triglycerides was observed. With the 4 g dose a reduction in total cholesterol at the expense of VLDL and HDL cholesterol and a reduction in VLDL triglycerides but no changes in total triglycerides was observed. No changes in serum lipids were observed with 2 g dose. In patients with type IIA hyperlipidemia, a significant positive correlation was observed between DHA+EPA content of plasma phospholipids and LDL cholesterol, this correlation was not observed in patients with IIB or IV phenotypes. It is concluded that omega-3 fatty acids are ineffective as the only treatment for dislipidemias refractory to diet.
Arteaga
A
A
Depto de Endocrinología, Metabolismo y Nutrición, Facultad de Medicina, Universidad Católica de Chile, Santiago de Chile.
Villanueva
C L
CL
Skorin
C
C
Guasch
V
V
Solís de Ovando
F
F
Velasco
N
N
Acosta
A M
AM
Leighton
F
F
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000517:prevention & control; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D015525:Fatty Acids, Omega-3; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
Dislipidemicos con cardiopatia coronaria. Efecto de diferentes dosis de acidos grasos omega 3 sobre los lipidos y lipoproteinas sericas.