Neurologic disease in Sjögren's syndrome: mononuclear inflammatory vasculopathy affecting central/peripheral nervous system and muscle. A clinical review and update of immunopathogenesis.
There is a growing appreciation that a subset of patients with primary Sjögren's syndrome (SS) also may develop a spectrum of central nervous system (CNS) complications. This article defines SS and its significance; discusses CNS, peripheral nervous system, and muscular complications of SS; identifies those areas in general or internal medicine in which SS patients with potential neurologic complications may present; describes those neurologic disorders that SS may mimic; places into perspective the controversy regarding the frequency and significance of CNS-SS; and extends our observations on the immunopathogenesis of neurologic complications in SS.
Alexander
E L
EL
Division of Molecular and Clinical Rheumatology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
D001323:Autoantibodies; D002493:Central Nervous System Diseases / Q000276:immunology*; D006801:Humans; D009135:Muscular Diseases / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000150:complications*; D014657:Vasculitis / Q000276:immunology*
D001323:Autoantibodies