Continuous arteriovenous hemoperfusion in meprobamate poisoning.
A patient with severe meprobamate poisoning presented within 4 h after suicidal ingestion of an unknown amount of the drug. The patient was unconscious, unresponsive, and hypotensive. Continuous arteriovenous hemoperfusion with coated activated charcoal resulted in a clearance of 198.8 +/- 15.6 mL/min with an extraction ratio of 0.66 +/- 0.05 (n = 3). There was almost complete elimination of the drug from the blood by 16 h. Continuous arteriovenous hemoperfusion, which can be performed in areas where dialysis facilities are not available, may be an effective adjunct to the treatment of acute meprobamate intoxication, particularly in patients with profound hypotension.
Lin
J L
JL
Division of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
Lim
P S
PS
Lai
B C
BC
Lin
W L
WL
D000328:Adult; D002606:Charcoal / Q000627:therapeutic use; D005260:Female; D006207:Half-Life; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007408:Intestinal Absorption; D008620:Meprobamate / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D008657:Metabolic Clearance Rate
D002606:Charcoal; D008620:Meprobamate