Amides and formamidines with antinociceptive activity (note II).
Forty amides, formamidines and trifluoromethylsulfonylamides bearing on the nitrogen a cyclohexyl residue, eventually 2-substituted, were prepared and tested for analgesic activity against a chemical stimulus. Good activity was exhibited by amides 9, 11 and 28, by formamidine 34, as well as by triflyamide 40. Eleven additional compounds exhibited a moderate activity.
Pau
A
A
Istituto di Analitica Farmaceutica, Università di Sassari, Italy.
Boatto
G
G
Cerri
R
R
Palomba
M
M
Nicolai
M
M
Sparatore
F
F
Varoni
M V
MV
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice
D000577:Amides; D000578:Amidines; D000700:Analgesics; C077922:formamidine