Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker rat.
N-Ethyl-N-nitrosourea-induced transplacental renal carcinogenesis in the rat results primarily in Wilms' tumors, apparently because primitive nephroblasts are the preferred target. Our question is whether N-ethyl-N-nitrosourea-induced mutations in the fetal kidney would increase the number of adult-type renal cell carcinomas in the Eker rat, which is heterozygous for a mutation that predisposes to renal cell carcinoma. Surprisingly, renal cell tumors but no Wilm's tumors began to appear from as early as 1 week after birth. Thus, the inheritance of a renal cell carcinoma mutation determines the specificity of tumor histology even with in utero carcinogenesis.
Hino
O
O
Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
Mitani
H
H
Knudson
A G
AG
D000818:Animals; D002292:Carcinoma, Renal Cell / Q000139:chemically induced / Q000235:genetics*; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D009154:Mutation; D009857:Oncogenes; D011247:Pregnancy; D051381:Rats; D011922:Rats, Mutant Strains; D009396:Wilms Tumor / Q000235:genetics
D005038:Ethylnitrosourea