A chronic Access Port model for direct delivery of drugs into the intestine of conscious dogs.
Gastric physiologic properties and emptying can significantly affect the stability and absorption of drugs given orally. A method to deliver drugs directly into the intestines and peritoneal cavity in conscious dogs by using a modified Vascular-Access Port (VAP) was developed and validated. Modified silastic VAP catheters size 7 or 9 French were placed in the duodenum, jejunum, colon, and/or peritoneal cavity in nine adult male dogs. Catheter placement was validated in six dogs by using contrast radiography and by monitoring the fecal excretion of blood after injection of blood via the VAP directly into the intestines. Three dogs were successfully used to evaluate the absorption of a peptide that inhibits platelet aggregation. Results showed this to be a feasible, easily validated model for delivering drugs directly into the intestines of conscious dogs.
Meunier
L D
LD
SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
Kissinger
J T
JT
Marcello
J
J
Nichols
A J
AJ
Smith
P L
PL
D000818:Animals; D002408:Catheters, Indwelling / Q000662:veterinary*; D004285:Dogs; D007408:Intestinal Absorption; D007422:Intestines; D008297:Male; D010456:Peptides, Cyclic / Q000008:administration & dosage; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage
D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors; C071275:SK&F 106760