Secretion of vasointestinal peptide by a primary liver tumor with rhabdoid features.
A 5-year-old child presented with an unresectable liver neoplasm, the histology of which resembled a malignant rhabdoid tumor. Clinical course was unrelenting despite therapy, and the child died four months later. During the course of her illness, she developed watery diarrhea and was found to have a high serum level of vasointestinal peptide (VIP). This is the first report of a childhood tumor with rhabdoid features to secrete VIP.
Weyman
C
C
Division of Pediatric Hematology/Oncology, University of Florida, Gainesville 32610.
Dolson
L
L
Kedar
A
A
D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000378:metabolism*; D018335:Rhabdoid Tumor / Q000097:blood / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide