title: Beat the clock: paradigms for NTPases in the maintenance of biological fidelity.
abstract: Kinetic proofreading is a strategy used by cells to reduce the number of errors made when replicating and expressing genetic information. Recent advances in mRNA splicing suggest a variation on the theme of previously described kinetic proofreading mechanisms, which may apply to other multicomponent assembly processes in the cell.
authors.affiliation: Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
authors.forename: S M
authors.initials: SM
authors.lastname: Burgess
authors.forename: C
authors.initials: C
authors.lastname: Guthrie
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D004261:DNA Replication; D043583:Nucleoside-Triphosphatase; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012441:Saccharomyces cerevisiae
chemical_list: D012333:RNA, Messenger; D017766:Acid Anhydride Hydrolases; D043583:Nucleoside-Triphosphatase