title: Parental childhood respiratory illness and respiratory illness in their infants. Group Health Medical Associates.
abstract: Parental histories of childhood respiratory trouble (CRT) were examined as risk factors for lower respiratory tract illnesses in healthy infants enrolled in the Children's Respiratory Study, Tucson, Arizona. A parental history of childhood respiratory trouble before age 16 was a risk factor for infantile lower respiratory tract illnesses (LRIs). Early age of onset of the parental CRT and those illnesses described as asthma or bronchiolitis showed the greatest risk: odds ratio = 2.8, P < 0.05. After controlling for known and suspected confounders, a parental history of CRT described as asthma or bronchiolitis with onset before age 3 was associated with wheezing LRIs in their children, with an odds ratio of 2.6, P < 0.05. A parental history of CRT described as bronchitis/croup was associated with nonwheezing LRIs in their children: odds ratio = 2.2, P < 0.05. These findings suggest a familial component to childhood respiratory trouble which may have a hereditary basis.
authors.affiliation: Respiratory Sciences Center, Arizona Health Sciences Center, Tucson 85724.
authors.forename: A E
authors.initials: AE
authors.lastname: Camilli
authors.forename: C J
authors.initials: CJ
authors.lastname: Holberg
authors.forename: A L
authors.initials: AL
authors.lastname: Wright
authors.forename: L M
authors.initials: LM
authors.lastname: Taussig
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001249:Asthma / Q000235:genetics; D001988:Bronchiolitis / Q000235:genetics; D001991:Bronchitis / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003440:Croup / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011014:Pneumonia / Q000235:genetics; D012140:Respiratory Tract Diseases / Q000235:genetics*; D012307:Risk Factors