title: Ventricular remodeling and infarct expansion.
abstract: Infarct expansion, defined as an alteration in the ventricular topography due to thinning and lengthening of the infarcted segment, develops within the first few hours of the acute symptoms, mostly in patients with a large, transmural, anterior myocardial infarction. Shape changes, peculiar to risk region location and due to disparity in regional ventricular architecture, could be posited as the first step in the process of infarct expansion, with various cellular mechanisms contributing to subsequent continued early and late ventricular dilation. Because the increase in left ventricular volume is expected to be linearly dependent on the extent of the infarction, limiting infarct size, by thrombolysis, would proportionally reduce enlargement of the cavity. The effect of thrombolysis on left ventricular volume, however, seems not to be completely accounted for by the lessening effect of reperfusion on infarct size, because data suggest a restraining effect of reperfusion on the process of ventricular dilation in addition to the lessening effect on infarct size. If this turns out to be true, then the achievement of a patent vessel even beyond the time period when that patency may be expected to salvage myocardium would be further justified. Theoretical predictions substantiate the potential effectiveness in restraining ventricular dilation of stiffening of the necrotic region alone, independently of myocardial salvage in infarcted patients. The process of progressive ventricular dilation involves not only a primary alteration in function of the infarcted region, but also a time-dependent secondary change in the noninfarcted tissue itself, finalized to restore stroke volume despite a persistently depressed ejection fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Cardiology, University of Verona, Ospedale Maggiore, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Zardini
authors.forename: P
authors.initials: P
authors.lastname: Marino
authors.forename: G
authors.initials: G
authors.lastname: Golia
authors.forename: M
authors.initials: M
authors.lastname: Anselmi
authors.forename: M
authors.initials: M
authors.lastname: Castelli
mesh_terms: D000818:Animals; D004452:Echocardiography; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology*