"Syndrome X" and coronary artery disease.
BACKGROUND
"Syndrome X" is a heterogeneous disorder that probably encompasses several disease states. The long-term prognosis in syndrome X is good, although a significant number of patients continue to experience chest pain and remain functionally limited. Several studies have reported that the development of coronary artery disease in patients with syndrome X is rare. Our experience, however, has shown that patients diagnosed as having syndrome X may develop atherosclerotic coronary artery disease over a relatively short period of time.


METHODS
Three patients with syndrome X were studied with repeat coronary angiography.


CONCLUSIONS
We describe the development of coronary artery disease in three syndrome X patients over a relatively short time after their normal coronary angiogram. Accordingly, the physician should remain alert to this possibility.
Chauhan
A
A
Regional Cardiac Unit, Papworth Hospital, Cambridge, England, UK.
Petch
M C
MC
Schofield
P M
PM
D000328:Adult; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D011379:Prognosis