title: Sedative effect of galphimine B, a nor-seco-triterpenoid from Galphimia glauca.
abstract: Galphimia glauca Cav. (Malpighiaceae) is used in Mexican traditional medicine as a sedative in the treatment of mental disorders. Sedative properties of a methanolic extract of the aerial parts of this plant have been established in animal trials and an active compound, named galphimine B, has already been isolated. This compound was submitted to neuropharmacological testing, where it was shown that galphimine B had no significant effect as an anticonvulsant, while it exhibited a strong depressant activity on the nervous system.
authors.affiliation: Unidad de Investigaciòn Biomédica de Sur, Centro de Investigaciòn de Plantas Medicinales, Morelos, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Tortoriello
authors.forename: A
authors.initials: A
authors.lastname: Ortega
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006993:Hypnotics and Sedatives / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D014315:Triterpenes; C084708:galphimine B