MK-801-induced symptoms of sensitization. The lack of correlation with the extracellular concentration of dopamine in the rat prefrontal cortex.
It was found that MK-801 evoked signs of behavioral sensitization to its own behavioral effects. A second injection of MK-801 (0.4 mg/kg) given 24 h after the first one (also 0.4 mg/kg) evoked stronger behavioral effects than the first dose. MK-801 (0.4 mg/kg) enhanced the extracellular concentration of dopamine (DA) in the prefrontal cortex (PFC). A second dose of MK-801 (0.4 mg/kg) given 24 h after the first one, evoked a quantitatively similar effect on the extracellular concentration of DA. The above results indicate that, at least in the PFC, the enhanced behavioral responsiveness to subsequent doses of MK-801 is not correlated with alterations in the extracellular concentration of DA.
Wedzony
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K
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Gołembiowska
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K
Klimek
V
V
D000818:Animals; D016291:Dizocilpine Maleate / Q000008:administration & dosage*; D004298:Dopamine / Q000378:metabolism*; D004334:Drug Administration Schedule; D006948:Hyperkinesis / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D016291:Dizocilpine Maleate; D004298:Dopamine