Myoclonic spasms during treatment with high doses of intravenous morphine in renal failure.
Myoclonic spasms occurred in a patient suffering from renal failure after high doses of continuous intravenous morphine (100 mg/h). The concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide (mumol/l) in plasma were: 1.93, 52.06 and 381.8, and in cerebrospinal fluid were: 1.02, 5.86 and 61.82, respectively. The role of morphine and morphine glucuronides in myoclonic spasms is discussed.
Sjøgren
P
P
Department of Anaesthesia, Herlev Hospital, Denmark.
Dragsted
L
L
Christensen
C B
CB
D058186:Acute Kidney Injury / Q000628:therapy*; D004831:Epilepsies, Myoclonic / Q000139:chemically induced*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D006435:Renal Dialysis
D009020:Morphine