title: Identification of a population of amacrine cells rich in insulin receptors.
abstract: Insulin receptor immunoreactivity in the developing chick retina was examined by immunocytochemistry. Insulin receptor immunoreactivity could be detected throughout the retina at all stages studied. Beginning at E12, a limited number of amacrine cells located in the inner level of the inner nuclear layer were strongly immunoreactive. By E19 there was a decrease in immunoreactivity throughout the retina, with the exception of the ganglion cell layer and a few amacrine cells and their process; this distribution was present in 3-day-old posthatched chick retina. The pattern of immunoreactivity of insulin receptors may indicate a unique role for insulin in the development and physiology of some amacrine cells.
authors.affiliation: Department of Biological Sciences, Rutgers University, Piscataway, NJ 08855.
authors.forename: A G
authors.initials: AG
authors.lastname: Hyndman
mesh_terms: D000818:Animals; D002642:Chick Embryo; D007074:Immunoglobulin G / Q000276:immunology; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D011972:Receptor, Insulin / Q000276:immunology / Q000378:metabolism*; D012160:Retina / Q000196:embryology / Q000276:immunology / Q000378:metabolism*
chemical_list: D007074:Immunoglobulin G; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin