Human papillomavirus, type 16, DNA in multicentric anogenital neoplasia associated with idiopathic panmyelopathy. A case report.
A 27-year-old woman suffering from panmyelopathy for six years presented with a cervical low grade squamous intraepithelial lesion (SIL), vulvar high grade SIL and perianal squamous cell carcinoma with an inguinal metastasis. Southern blot hybridization with 32P-labeled human papillomavirus (HPV) DNA revealed HPV 16 DNA in varying copy numbers in material from the four locations. HPV 16 genomes persisting after surgery on the perianal tumor area were no longer detectable after betatron radiotherapy.
Ikenberg
H
H
Department of Obstetrics and Gynecology, University of Freiburg, Germany.
Göppinger
A
A
Hilgarth
M
M
Pfisterer
J
J
Müller
U
U
Hillemanns
H G
HG
Pfleiderer
A
A
D000008:Abdominal Neoplasms / Q000382:microbiology* / Q000473:pathology / Q000556:secondary; D000328:Adult; D001005:Anus Neoplasms / Q000382:microbiology* / Q000473:pathology; D001855:Bone Marrow Diseases / Q000150:complications* / Q000276:immunology; D002278:Carcinoma in Situ / Q000382:microbiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000382:microbiology* / Q000473:pathology / Q000556:secondary; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D005833:Genital Neoplasms, Female / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D007264:Inguinal Canal; D009378:Neoplasms, Multiple Primary / Q000382:microbiology* / Q000473:pathology; D027383:Papillomaviridae / Q000302:isolation & purification*
D004279:DNA, Viral