title: Anticoccidial efficacy of semduramicin. 2. Evaluation against field isolates including comparisons with salinomycin, maduramicin, and monensin in battery tests.
abstract: The efficacy of semduramicin (AVIAX), a novel polyether ionophore, was profiled in a series of 57 battery tests conducted in the United States and the United Kingdom. The studies employed mixed and monospecific infections of Eimeria acervulina, Eimeria mivati/Eimeria mitis, Eimeria brunetti, Eimeria maxima, Eimeria necatrix, and Eimeria tenella derived from North American and European field isolates. Ten-day-old broiler cockerels in pens of 8 to 10 birds were continuously medicated in feed beginning 24 h before challenge in tests of 6 to 8 days' duration. At the use level of 25 ppm, semduramicin effectively controlled mortality, lesions, and weight gain depression that occurred in unmedicated, infected controls for all species. In comparison with 60 ppm salinomycin, semduramicin significantly (P < .05) improved weight gain against E. brunetti and E. tenella, lesion control against E. brunetti and E. maxima, and the control of coccidiosis mortality against E. tenella. Salinomycin was superior (P < .05) to all treatments in maintenance of weight gain and control of lesions for E. acervulina. Maduramicin at 5 ppm was inferior (P < .05) to semduramicin in control of E. acervulina and E. maxima lesions, but was superior (P < .05) to all treatments in maintenance of weight gain and control of lesions in E. tenella infections. The data indicate that semduramicin at 25 ppm is well tolerated in broilers and possesses broad spectrum anticoccidial activity.
authors.affiliation: Central Research Division, Pfizer Inc., Terre Haute, Indiana 47808.
authors.forename: N B
authors.initials: NB
authors.lastname: Logan
authors.forename: M E
authors.initials: ME
authors.lastname: McKenzie
authors.forename: D P
authors.initials: DP
authors.lastname: Conway
authors.forename: L R
authors.initials: LR
authors.lastname: Chappel
authors.forename: N C
authors.initials: NC
authors.lastname: Hammet
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D004539:Eimeria; D007783:Lactones / Q000627:therapeutic use; D008297:Male; D008985:Monensin / Q000627:therapeutic use; D009550:Nigericin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D011714:Pyrans / Q000627:therapeutic use; D013045:Species Specificity; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects; D000095662:Polyether Polyketides
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D008985:Monensin; D009550:Nigericin; D011714:Pyrans; C018091:maduramicin; C010327:salinomycin; D000095662:Polyether Polyketides; C072941:semduramicin