Synthesis and interactions with blood of polyetherurethaneurea/polypeptide block copolymers.
Polyurethane/polypeptide block copolymers were synthesized. Infrared spectroscopy and differential scanning calorimetry revealed that in the block copolymers both segments undergo phase-mixing, while in polyurethane/polypeptide blend both components undergo phase-separation. Contact angle measurement showed that in the block copolymers polyurethane segments tended to appear on the membrane surface, whereas in polyurethane/polypeptide blend polypeptide components appeared on the membrane surface. In vitro nonthrombogenicity of the block copolymers was similar to that of homopolymers or polymer blends, though adhesion and deformation of platelets were suppressed on the block copolymer membranes.
Ito
Y
Y
Department of Polymer Chemistry, Kyoto University, Japan.
Miyashita
K
K
Kashiwagi
T
T
Imanishi
Y
Y
D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion / Q000187:drug effects; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D011108:Polymers; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D001672:Biocompatible Materials; D010455:Peptides; D011108:Polymers; D011140:Polyurethanes; C084990:polyetherurethaneurea-polypeptide block copolymer