Delayed hypersensitivity testing as a clinical measure of cell-mediated immunity in the cat.
The purposes of this study were to examine the cell-mediated immune response of the normal cat to the modified live feline viral rhinitis, calicivirus, and parvovirus (FVRCP) vaccine (Felocell CVR, Norden, Lincoln, NE), and to evaluate the intradermal skin test as a clinical measure of the immune response of cats. Vaccine and diluent were injected intradermally on the dorsal pinna of 34 normal adult cats. Skin thickness measurements, lymphocyte counts, and Concanavalin A mitogenesis indices were evaluated in 18 of these cats. Skin biopsies were obtained in 16 cats. In normal cats, the FVRCP vaccine induced a delayed hypersensitivity response characterized by a mononuclear infiltrate most pronounced at 72 h. Five cats with either feline leukemia (FeLV) or feline immunodeficiency virus (FIV) were tested and had a significantly reduced response to the skin test. The skin test provides a clinically useful method of evaluating immune function in cats and may be useful in development of a prognostic index.
Otto
C M
CM
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Brown
C A
CA
Lindl
P A
PA
Dawe
D L
DL
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D017927:Calicivirus, Feline / Q000276:immunology; D002415:Cats; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology*; D028301:Feline Panleukopenia Virus / Q000276:immunology; D005260:Female; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D007111:Immunity, Cellular; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D016582:Leukemia, Feline / Q000276:immunology*; D008297:Male; D012229:Rhinovirus / Q000276:immunology; D012882:Skin Tests / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines