Anti-tumor promoting activities of natural products. II. Inhibitory effects of digitoxin on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors.
Two-stage carcinogenesis of mouse skin papillomas induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), and mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide (4NQO) and glycerol, were inhibited by digitoxin (1).
Inada
A
A
Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Nakanishi
T
T
Konoshima
T
T
Kozuka
M
M
Tokuda
H
H
Nishino
H
H
Iwashima
A
A
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D004074:Digitoxin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005990:Glycerol / Q000633:toxicity; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D016588:Anticarcinogenic Agents; D015127:9,10-Dimethyl-1,2-benzanthracene; D004074:Digitoxin; D013755:Tetradecanoylphorbol Acetate; D005990:Glycerol