Relationship between antifungal activity and hydrophobicity of kojic acid derivatives.
Twenty three kojic acid derivatives were tested in the agar diffusion test against twenty five dermatophytic fungi. The inhibitory effects at equal doses (10 mg/L) were correlated with the 1-octanol-water partition coefficients of the compounds. An improvement in antifungal activity can be achieved by increasing the hydrophobicity of the compounds.
Baláz
S
S
Department of Biochemical Technology, Faculty of Chemical Technology, Slovak Polytechnic University, Bratislava.
Uher
M
M
Brtko
J
J
Veverka
M
M
Bransová
J
J
Dobias
J
J
Pódová
M
M
Buchvald
J
J
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D011753:Pyrones; C011890:kojic acid