Formation-stimulating regimens other than sodium fluoride.
Although no bone formation-stimulating regimen has been approved for treatment of established osteoporosis, there are a number of potentially effective drugs that are in various stages of preclinical and clinical testing. The two that show the greatest potential and the ones most likely to become available initially for clinical treatment are a parathyroid hormone fragment, PTH(1-34), and insulin-like growth factor-I. A promising approach for the future is to discover orally active agents that enhance the local production of growth factors by bone cells. It is likely that effective formation-stimulating regimens will become available for treating established osteoporosis within the next 5 years.
Riggs
B L
BL
Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota 55905.
D045930:Anabolic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002117:Calcitriol / Q000494:pharmacology / Q000627:therapeutic use; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology / Q000627:therapeutic use*; D009640:Norethindrone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000077563:Norethindrone Acetate; D010012:Osteogenesis / Q000187:drug effects*; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D045167:Progesterone Congeners / Q000494:pharmacology / Q000627:therapeutic use; D019379:Teriparatide
D045930:Anabolic Agents; D004164:Diphosphonates; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D045167:Progesterone Congeners; D019379:Teriparatide; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D000077563:Norethindrone Acetate; D002117:Calcitriol; D009640:Norethindrone