title: Comparison of the cardiac force-time integral with energetics using a cardiac muscle model.
abstract: Several investigators have found experimentally that the force-time integral varies non-linearly with energy expenditure over the course of a cardiac contraction. Also, recent research findings have indicated that the crossbridge cycle to ATP hydrolysis ratio in muscle fiber systems may not be coupled with a one-to-one ratio. In order to investigate these findings, Huxley's sliding filament crossbridge muscle model coupled with parallel and series elastic components was simulated to examine the behavior of the crossbridge energy utilization and force-time integral vs time. Crossbridge (CB) energy utilization was determined by considering the ATP hydrolysis for the crossbridge cycling, and this CB energy was compared with the force-length energy in a contraction. This CB energy was calculated in both isometric and isotonic contractions as a function of contraction time and compared to the force-time integral. Simulation results demonstrated that the ratio of the force-time integral to CB energy varies strongly throughout the cardiac cycle for both isometric and isotonic cases, as has been observed experimentally. Simulations also showed that using the force-length energy component of energy vs the CB energy gave a better correlation between the total energetic predictions and the force-time integral, agreeing with recent finding that the crossbridge cycle to ATP hydrolysis ratio may not be coupled one-to-one, especially at lower force levels.
authors.affiliation: National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: T W
authors.initials: TW
authors.lastname: Taylor
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Hata
authors.forename: T
authors.initials: T
authors.lastname: Takasago
authors.forename: A
authors.initials: A
authors.lastname: Saeki
authors.forename: T
authors.initials: T
authors.lastname: Nishioka
authors.forename: H
authors.initials: H
authors.lastname: Suga
mesh_terms: D000199:Actins / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001481:Basal Metabolism / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D003198:Computer Simulation; D004285:Dogs; D004548:Elasticity; D004734:Energy Metabolism / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006868:Hydrolysis; D007537:Isometric Contraction / Q000502:physiology; D007551:Isotonic Contraction / Q000502:physiology; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D009210:Myofibrils / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D009218:Myosins / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D010210:Papillary Muscles / Q000378:metabolism* / Q000502:physiology* / Q000648:ultrastructure; D012518:Sarcomeres / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000199:Actins; D000255:Adenosine Triphosphate; D009218:Myosins; D002118:Calcium