title: Extra-hepatic transcription of plasma prekallikrein gene in human and rat tissues.
abstract: The expression of plasma prekallikrein (PPK) mRNA has been investigated applying reverse transcription, followed by polymerase chain reaction, of mRNA (RT-PCR) in various human and rat tissues. PPK gene transcripts were detected in liver and kidney in both species and, in addition, in human adrenal gland and placenta. No PPK mRNA was identified in rat adrenal gland, heart, aorta, lung, brain cortex and medulla, hypothalamus, and uterus. These results show that PPK gene expression is not restricted to the liver.
authors.affiliation: German Institute for High Blood Pressure Research, University of Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ciechanowicz
authors.forename: M
authors.initials: M
authors.lastname: Bader
authors.forename: J
authors.initials: J
authors.lastname: Wagner
authors.forename: D
authors.initials: D
authors.lastname: Ganten
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D015870:Gene Expression; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011288:Prekallikrein / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D015183:Restriction Mapping; D014158:Transcription, Genetic
chemical_list: D017931:DNA Primers; D016376:Oligonucleotides, Antisense; D012333:RNA, Messenger; D011288:Prekallikrein