title: Unilateral renal artery revascularization can salvage renal function and terminate dialysis in selected patients with uremia.
abstract: Revascularization of renal arteries to salvage glomerular function in patients with chronic renal failure is performed infrequently. However, during the past 12 months we have encountered three patients over 60 years of age known to have chronic renal failure who were on dialysis for 2 weeks, 3 weeks, and 2 months, respectively. All three patients were hypertensive, requiring between four and five antihypertensive medications. One patient was ventilator dependent in intractable cardiac failure with pulmonary artery systolic pressures ranging from 60 to 70 mm Hg. Standard biplanar arteriography revealed occlusion of the left renal artery with distal reconstitution in two patients and a 99% stenosis of the right renal artery in the remaining patient. The contralateral renal artery was totally occluded in two patients and diffusely stenotic in one. The recipient kidneys measured 8, 10, and 11 cm in length. Kidney function was assessed by renal scintigraphy and creatinine clearance. Two splenorenal bypasses and one hepatorenal bypass with 6 mm polytetrafluoroethylene graft were performed successfully. After surgery, renal function improved in all patients with two of three patients resuming normal function as evidenced by reduction of serum creatinine levels to 0.9 and 1.3 mg/dl. The third patient recovered to have a creatinine level of 3.2 mg/dl. All patients were discharged home within 1 month with a daily urine output greater than 1500 ml. At discharge, each patient required only two antihypertensive medications to control blood pressure. Duplex scanning 3, 6, and 12 months after surgery confirmed patency of all reconstructions.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Vascular Surgery, Maimonides Medical Center, Brooklyn, NY 11219.
authors.forename: E
authors.initials: E
authors.lastname: Ascer
authors.forename: M
authors.initials: M
authors.lastname: Gennaro
authors.forename: D
authors.initials: D
authors.lastname: Rogers
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000150:complications / Q000601:surgery*; D006435:Renal Dialysis; D014511:Uremia / Q000209:etiology / Q000628:therapy*; D014656:Vascular Surgical Procedures / Q000379:methods