Steroid hormones retard aflatoxin-induced cytotoxicity.
Protective effect of sex steroid hormones on aflatoxin-induced cytotoxicity on RBC (hemolysis) was examined in vitro. Addition of aflatoxin (2 micrograms/ml) in RBC suspension caused significant increase in hemolysis. Concurrent addition of aflatoxin (2 micrograms/ml) and estradiolbenzoate (100-1200 pg/ml) in RBC suspension significantly retarded aflatoxin-induced hemolysis. Similarly, addition of aflatoxin (2 micrograms/ml) along with testosterone propionate (5-60 ng/ml) in RBC suspension retarded aflatoxin-induced hemolysis. Among the two synthetic hormones studied estradiolbenzoate was more potent than testosterone propionate.
Raval
P J
PJ
Department of Life Sciences, Bhavnagar University, India.
Verma
R J
RJ
D000328:Adult; D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D013739:Testosterone / Q000494:pharmacology
D000348:Aflatoxins; D013739:Testosterone; D004958:Estradiol; C010452:estradiol-17 beta-benzoate