n-3 PUFA and alpha-tocopherol control of tumor cell proliferation.
Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E.
Bartoli
G M
GM
Department of Biology, Tor Vergata University, Rome, Italy.
Palozza
P
P
Marra
G
G
Armelao
F
F
Franceschelli
P
P
Luberto
C
C
Sgarlata
E
E
Piccioni
E
E
Anti
M
M
D011125:Adenomatous Polyposis Coli / Q000517:prevention & control*; D001345:Autoradiography / Q000379:methods; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D004311:Double-Blind Method; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D012007:Rectum / Q000473:pathology; D012307:Risk Factors; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014810:Vitamin E / Q000032:analysis / Q000378:metabolism
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014316:Tritium; D014810:Vitamin E; D013936:Thymidine