Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties.
A new inhibitor of mammalian adenosine triphosphatases, designated aquastatin A, has been isolated from a fungus identified as Fusarium aquaeductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na+/K(+)-ATPase with an IC50 value of 7.1 microM, and H+/K(+)-ATPase with an apparent IC50 value of 6.2 microM.
Hamano
K
K
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Kinoshita-Okami
M
M
Minagawa
K
K
Haruyama
H
H
Kinoshita
T
T
Hosoya
T
T
Furuya
K
K
Kinoshita
K
K
Tabata
K
K
Hemmi
A
A
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004285:Dogs; D005285:Fermentation; D005670:Fusarium / Q000737:chemistry*; D005697:Galactosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012459:Salicylates; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013552:Swine
D001565:Benzoates; D005697:Galactosides; D012459:Salicylates; C085031:aquastatin A; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase