title: Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells.
abstract: Homologous desensitization of responses to bombesin in small cell lung cancer cells can be mimicked by protein kinase C-activating phorbol esters. We show that phorbol ester-induced desensitization can be blocked by prior treatment with the protein kinase C inhibitor staurosporine or prolonged pretreatment with phorbol esters. However, under these conditions, homologous desensitization to bombesin persists. These data indicate that phorbol ester-induced desensitization is distinguishable from bombesin-induced homologous desensitization. Protein kinase C is not a dominant component in the homologous desensitization to bombesin in small cell lung cancer cells.
authors.affiliation: Department of Medicine, Montreal General Hospital, PQ, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Frankel
authors.forename: J
authors.initials: J
authors.lastname: Viallet
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D001839:Bombesin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D018288:Carcinoma, Small Cell / Q000503:physiopathology*; D015536:Down-Regulation; D004789:Enzyme Activation; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000503:physiopathology*; D011493:Protein Kinase C / Q000502:physiology*; D019311:Staurosporine; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D011493:Protein Kinase C; D019311:Staurosporine; D001839:Bombesin; D002118:Calcium