Huntington's disease and low tryptophan diet.
Beal et al have postulated that abnormal metabolism of tryptophan or quinolinic acid underlies the mechanism which causes brain damage in Huntington's disease. A case history is reported where a low tryptophan diet was associated with an unexpectedly good outcome. It is possible that a low tryptophan diet may alter the course of Huntington's disease, either by postponing onset or diminishing the severity of symptoms.
Pascoe
M
M
Royal Children's Hospital, Melbourne, Australia.
D001921:Brain / Q000378:metabolism; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000178:diet therapy* / Q000209:etiology / Q000517:prevention & control; D008954:Models, Biological; D009410:Nerve Degeneration / Q000502:physiology; D017378:Quinolinic Acid / Q000378:metabolism; D014364:Tryptophan / Q000008:administration & dosage* / Q000378:metabolism
D014364:Tryptophan; D017378:Quinolinic Acid