title: Wolfram syndrome: a clinical study of two cases.
abstract: Two unrelated patients with two different images of Wolfram (or 'DIDMOAD') syndrome are presented: a 19-year old woman suffering from all the important features of this syndrome, and a 38-year old man showing two major characteristics but several minor abnormalities. This syndrome should be considered in young diabetic patients with unexplained visual loss or with polyuria and polydipsia in the presence of adequate blood sugar control. An early diagnosis is important to prevent unnecessary diagnostic investigations.
authors.affiliation: Department of Ophthalmology, Middelheimziekenhuis, Antwerp, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Van den Bergh
authors.forename: T
authors.initials: T
authors.lastname: Zeyen
authors.forename: J
authors.initials: J
authors.lastname: Verhelst
authors.forename: C
authors.initials: C
authors.lastname: Mahler
mesh_terms: D000328:Adult; D005260:Female; D005654:Fundus Oculi; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000473:pathology; D009896:Optic Atrophy / Q000473:pathology; D014567:Urography; D014792:Visual Acuity; D014794:Visual Fields; D014929:Wolfram Syndrome / Q000175:diagnosis* / Q000503:physiopathology