Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin.
All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 microgram/ml) and ceftazidime (MIC50, 4 micrograms/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 microgram/ml; those for ciprofloxacin and ofloxacin were > 16 and 16 micrograms/ml, respectively.
McWhinney
P H
PH
Department of Microbiology, Royal Free Hospital School of Medicine, London, United Kingdom.
Patel
S
S
Whiley
R A
RA
Hardie
J M
JM
Gillespie
S H
SH
Kibbler
C C
CC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009503:Neutropenia / Q000097:blood / Q000150:complications*; D013290:Streptococcal Infections / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin