Effectiveness of cyclophosphamide pulse treatment in Wegener's granulomatosis.
43 patients with Wegener's granulomatosis were studied to evaluate the effectiveness of cyclophosphamide (cyc) pulse treatment. 42% of the patients showed benefits from treatment for at least 6 months after the cessation of cyc pulses. Analysis of clinical and laboratory parameters indicate that this treatment is less effective in patients in whom more than 4 organ systems are involved. Responders to the treatment showed disease manifestations predominantly in the ENT and lower respiratory tract and had lower cANCA titers (< 1:64) prior to treatment.
Reinhold-Keller
E
E
Department of Clinical Rheumatology, Medical University at Lübeck, Germany.
Kekow
J
J
Schnabel
A
A
Schwarz-Eywill
M
M
Schmitt
W H
WH
Gross
W L
WL
D000293:Adolescent; D000328:Adult; D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
D003520:Cyclophosphamide