title: Utilization of intravenously infused maltooligosaccharides in rabbits.
abstract: The utilization of intravenously infused maltotriose, maltotetraose and maltopentaose was investigated in rabbits. Rabbits were infused with isotonic solutions of each maltooligosaccharide for 2 h and the utilization was assessed by the 24-h urinary loss of carbohydrates. The utilization of these maltooligosaccharides was good (> or = 87.5%) at a rate of 1 ml/kg/h (< or = 250 mg/kg/h) and poor (< or = 36.2%) at a rate of 5 ml/kg/h (> 250 mg/kg/h). Furthermore, these maltooligosaccharides infused as 5% solution showed good utilization (> or = 86.2%) at a rate of 5 ml/kg/h (250 mg/kg/h). These results suggest the existence of a threshold dose in the utilization of intravenously infused maltooligosaccharides, and this threshold value in rabbits is estimated to be nearly 250 mg/kg/h.
authors.affiliation: Pharmacy Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Maruo
authors.forename: H
authors.initials: H
authors.lastname: Mukai
authors.forename: A
authors.initials: A
authors.lastname: Morino
mesh_terms: D000818:Animals; D007262:Infusions, Intravenous; D008297:Male; D008320:Maltose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism; D009844:Oligosaccharides / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D014312:Trisaccharides / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D009844:Oligosaccharides; D014312:Trisaccharides; C019193:maltopentaose; C008317:maltotriose; D008320:Maltose; C009819:maltotetraose