title: Conjunctival involvement in malignancy-associated acanthosis nigricans.
abstract: Acanthosis nigricans classically presents with pigmented skin lesions over the neck, groin and axillae. It may involve the mucosal surfaces, particularly the oral mucosa. Conjunctival involvement is very rare, especially in the variety associated with malignancy. We report a case of acanthosis nigricans associated with squamous cell carcinoma of the bronchus where bilateral papillary conjunctivitis, progressing to hypertrophic papillary conjunctival and lid margin lesions, was the presenting feature. Topical treatment with corticosteroid and artificial tear drops resulted in the partial improvement of the ocular symptoms.
authors.affiliation: Department of Ophthalmology, St George's Hospital, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Tabandeh
authors.forename: S
authors.initials: S
authors.lastname: Gopal
authors.forename: M
authors.initials: M
authors.lastname: Teimory
authors.forename: T
authors.initials: T
authors.lastname: Wolfensberger
authors.forename: I K
authors.initials: IK
authors.lastname: Luke
authors.forename: I
authors.initials: I
authors.lastname: Mackie
authors.forename: N
authors.initials: N
authors.lastname: Dilly
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D000368:Aged; D001984:Bronchial Neoplasms / Q000150:complications* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D003228:Conjunctiva / Q000473:pathology; D003231:Conjunctivitis / Q000150:complications* / Q000473:pathology; D006801:Humans; D006984:Hypertrophy; D008297:Male