title: [Genetic regulation of limb development in vertebrates].
abstract: The data are surveyed concerning formation of limb buds in Vertebrate, development of morphogenetic fields in limb buds, their organization based on the simple gradient model and the model of polar coordinates. Formation of the morphogenetic fields of strictly located events, such as chondrogenesis and prescheduled cell death, based on the positional information is discussed. All the stages of limb formation in Vertebrate are under genetic control, the products of some genes behaving as extracellular factors (morphogens) and those of other as cell receptors or transcriptional factors inducing activity of specific gene sets. Highly important at that are regulatory homeobox genes.
authors.forename: V A
authors.initials: VA
authors.lastname: Mglinets
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002356:Cartilage / Q000196:embryology; D005121:Extremities / Q000196:embryology*; D005786:Gene Expression Regulation / Q000502:physiology*; D008648:Mesoderm / Q000502:physiology; D009024:Morphogenesis / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014714:Vertebrates / Q000196:embryology / Q000235:genetics*
chemical_list: D014157:Transcription Factors
vernacular_title: Geneticheskaia reguliatsiia razvitiia konechnosteĭ u pozvonochnykh.