title: Using stable isotopes to assess reduced physical activity of individuals with Prader-Willi syndrome.
abstract: The contribution of reduced levels of physical activity to the positive energy balance found in most individuals with Prader-Willi syndrome is not known. We assessed total energy expenditure using stable isotopes and resting energy expenditure using open circuit indirect calorimetry in a group of 10 children with this syndrome. The difference between these two measures is primarily the energy cost of activity and is often called a physical activity level. After adjusting for age, we found that the physical activity level values of these children were significantly reduced in comparison to children who did not have Prader-Willi syndrome. Increasing activity levels in children with Prader-Willi syndrome will raise total energy expenditure and may help to control their development of weight gain.
authors.affiliation: Dunn Nutrition Unit, Cambridge, England.
authors.forename: P S
authors.initials: PS
authors.lastname: Davies
authors.forename: C
authors.initials: C
authors.lastname: Joughin
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001823:Body Composition / Q000502:physiology; D001834:Body Water / Q000502:physiology*; D002153:Calorimetry, Indirect / Q000379:methods*; D002648:Child; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011218:Prader-Willi Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D012016:Reference Values