title: MR imaging of deferoxamine-induced bone dysplasia in an 8-year-old female with thalassemia major.
abstract: Bone changes in thalassemic patients receiving deferoxamine therapy for iron chelation include metaphyseal and growth plate irregularities. We present a case of an 8-year-old female with thalassemia major, who had magnetic resonance imaging after plain radiographs had shown metaphyseal changes in the distal femur. The signal characteristics of these abnormalities were consistent with hyaline cartilage; the surrounding marrow showed no evidence of iron overload.
authors.affiliation: Department of Radiology and Nuclear Medicine, Hospital for Special Surgery, New York, NY.
authors.forename: T T
authors.initials: TT
authors.lastname: Miller
authors.forename: G
authors.initials: G
authors.lastname: Caldwell
authors.forename: J J
authors.initials: JJ
authors.lastname: Kaye
authors.forename: S
authors.initials: S
authors.lastname: Arkin
authors.forename: S
authors.initials: S
authors.lastname: Burke
authors.forename: P W
authors.initials: PW
authors.lastname: Brill
mesh_terms: D001848:Bone Diseases, Developmental / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002648:Child; D003676:Deferoxamine / Q000009:adverse effects*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D006132:Growth Plate / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D011859:Radiography; D017086:beta-Thalassemia / Q000188:drug therapy*
chemical_list: D003676:Deferoxamine