title: [New properties of trental as an inhibitor of viral activity with a wide range of activity].
abstract: Experimental investigations on the spectrum and degree of the expression of trental antiviral activity were carried out. The investigations were done in cell cultures and laboratory animals using laboratory strains (including drug-resistant ones) of 13 viruses, causative agents of human and animal infections. The drug demonstrated its activity against 8 viruses of 7 families. It was highly active against 5 viruses: herpes simplex virus (including its acyclovir-resistant strain), vaccinia virus (including its methisazone-resistant strain), rotavirus and tick-borne encephalitis virus. As regards other viruses, its activity was less pronounced (hepatitis JA virus) or low (vesicular stomatitis virus, West Nile virus). It was concluded that, being a cardiovascular drug, trental was an effective broad spectrum virus inhibitor.
authors.forename: T V
authors.initials: TV
authors.lastname: Amvros'eva
authors.forename: V I
authors.initials: VI
authors.lastname: Votiakov
authors.forename: O T
authors.initials: OT
authors.lastname: Andreeva
authors.forename: G V
authors.initials: GV
authors.lastname: Vladyko
authors.forename: S N
authors.initials: SN
authors.lastname: Nikolaeva
authors.forename: S V
authors.initials: SV
authors.lastname: Orlova
authors.forename: I A
authors.initials: IA
authors.lastname: Azarova
authors.forename: A A
authors.initials: AA
authors.lastname: Zgirovskaia
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D051379:Mice; D008826:Microbial Sensitivity Tests; D010431:Pentoxifylline / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D014777:Virus Diseases / Q000188:drug therapy; D014780:Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D010431:Pentoxifylline
vernacular_title: Novye svoĭstva trentala kak ingibitor virusnoĭ aktivnosti shirokogo spektra deĭstviia.