title: A sequential cell kinetic study of meningioma cells in primary explant culture using bromodeoxyuridine.
abstract: The present study was undertaken to evaluate the sequential BrdU-LI at weekly intervals upto four weeks in 18 primary explant cultures of meningiomas. This revealed three distinct patterns of growth which could be arbitrarily defined as 'degenerating' (group I), 'proliferating' (group II) and 'adaptive' (group III) types. Interestingly two cases of malignant and two of recurrent meningiomas fell into the 'degenerating' group I pattern. The possible explanations for the observed relatively higher in vitro LI values compared to lower in vivo values as reported in the literature and the theoretical implications of the three distinct patterns of sequential LI values are discussed.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
authors.forename: K
authors.initials: K
authors.lastname: Kharbanda
authors.forename: A K
authors.initials: AK
authors.lastname: Karak
authors.forename: C
authors.initials: C
authors.lastname: Sarkar
authors.forename: A K
authors.initials: AK
authors.lastname: Dinda
authors.forename: M
authors.initials: M
authors.lastname: Mathur
authors.forename: S
authors.initials: S
authors.lastname: Roy
mesh_terms: D000328:Adult; D001973:Bromodeoxyuridine / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D011897:Random Allocation; D014407:Tumor Cells, Cultured
chemical_list: D001973:Bromodeoxyuridine