The China I/CDC strain of Plasmodium malariae in Aotus monkeys and chimpanzees.
Five Aotus monkeys and two chimpanzees were infected with Plasmodium malariae isolated from a patient who acquired her infection approximately 50 years ago. All animals were splenectomized. The chimpanzees supported the highest parasite densities of 22,271/microliters and 18,544/microliters. Three Aotus monkeys with a previous history of infection with P. vivax had maximum parasite counts of from 1,818/microliters to 2,909/microliters, whereas two monkeys not previously infected had maximum parasite counts of 6,908/microliters. The establishment of new isolates in these animals aides the development of diagnostic probes and the identification of areas of antigenic variation within the species.
Collins
W E
WE
Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Lobel
H O
HO
McClure
H
H
Strobert
E
E
Galland
G G
GG
Taylor
F
F
Barreto
A L
AL
Roberto
R R
RR
Skinner
J C
JC
Adams
S
S
D000368:Aged; D000818:Animals; D001029:Aotus trivirgatus / Q000469:parasitology*; D002681:China; D002738:Chloroquine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000469:parasitology*; D008297:Male; D002679:Pan troglodytes / Q000469:parasitology*; D010965:Plasmodium malariae / Q000254:growth & development*; D013156:Splenectomy; D013997:Time Factors; D065227:Transfusion Reaction
D002738:Chloroquine