IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection.
T cell-mediated production of IFN-gamma followed infection of adult, but not neonatal NFS/N mice with Cas-Br-M murine leukemia virus (Cas). The IFN-gamma response was associated with the appearance of CTL specific for Cas and with age-dependent resistance to neurologic disease. While both immune responses were mediated by a CD8-enriched population of T cells, IFN-gamma did not play a role in the activation of the Cas-specific CTL response. However, when given exogenously, IFN-gamma delayed the onset and reduced the incidence of Cas-induced neurologic disease. These data suggest that the IFN-gamma response to Cas infection may be an important host defense mechanism whose effects on virus replication and neurologic disease expression are independent of its effect on Cas-specific CTL.
Sarzotti
M
M
Retrovirus Research Center, Veterans Affairs Medical Center, Baltimore, School of Medicine, Maryland.
Gomes
M da P
Mda P
Hoffman
P M
PM
D016475:3T3 Cells; D000375:Aging / Q000276:immunology; D000818:Animals; D001483:Base Sequence; D003602:Cytotoxicity, Immunologic; D017931:DNA Primers / Q000737:chemistry; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D009422:Nervous System Diseases / Q000276:immunology; D016133:Polymerase Chain Reaction; D012192:Retroviridae Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology*; D014779:Virus Replication
D017931:DNA Primers; D007371:Interferon-gamma