[Effect of enalapril on left ventricular hypertrophy and left ventricular function in patients with hypertension].
The aim of this study was to study the effect of enalapril (E) on left ventricular (LV) mass, LV function and blood renin-angiotensin (RA) in patients with hypertension. Sixteen hypertensives were included in this study (WHO I 8, WHO II 8, 49.5 +/- 10.5 yrs). They were examined for blood pressure and heart rate. Chest X-ray film, echocardiography (echo), X-ray computed tomography (CT) and RA before and after about 6 months of E administration were studied. The LV mass was calculated by CT. The LV function was measured by echo. RAS was unchanged during this study. LV mass was significantly reduced after E (121.4 +/- 25.6 vs 104.6 +/- 13.7 g/cm2). The LV systolic function was unchanged after E, but LV diastolic function improved. It was shown that the long-term administration of E improves LV hypertrophy and LV diastolic function without any change of RAS.
Kakinoki
S
S
Department of Cardiovascular Medicine, Hokkaido University School of Medicine.
Takechi
S
S
Hashimoto
M
M
Sakuma
I
I
Nomura
A
A
Kitabatake
A
A
Yasuda
H
H
D000328:Adult; D004656:Enalapril / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System / Q000187:drug effects; D014057:Tomography, X-Ray Computed; D016277:Ventricular Function, Left / Q000187:drug effects*
D004656:Enalapril