The role of adhesion molecules in the regulation of antibody responses.
We used the T-cell-dependent antigen, bacteriophage (phage) phi X174, to study antibody synthesis in patients, guinea pigs, and dogs with complement component deficiencies (C2, C4, C3, C7); in patients with adhesion molecule deficiencies (CD11/CD18 or sialylated Lewisx); and in patients with the hyper IgM (HIM) syndrome (absence of functional gp39 expression by activated T cells). Patients and guinea pigs deficient in early complement components, patients deficient in CD11/CD18, and patients lacking functional gp39 on activated T cells responded to repeated phage immunizations with depressed antibody titers, lack of or inadequate amplification, and failure to switch from IgM to IgG, suggesting that defective T-cell-B-cell interaction is the cause of the antibody deficiency observed in these patients.
Ochs
H D
HD
Department of Pediatrics, University of Washington School of Medicine, Seattle 98195.
Nonoyama
S
S
Farrington
M L
ML
Fischer
S H
SH
Aruffo
A
A
D000818:Animals; D000917:Antibody Formation; D000956:Antigens, Viral; D010584:Bacteriophage phi X 174 / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology*; D003165:Complement System Proteins / Q000172:deficiency; D004285:Dogs; D008040:Genetic Linkage; D006023:Glycoproteins / Q000172:deficiency; D006168:Guinea Pigs; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007589:Job Syndrome / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014960:X Chromosome
D000956:Antigens, Viral; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D003165:Complement System Proteins