title: Uterine leiomyosarcomas coexistent with cellular and atypical leiomyomata in a young woman during the treatment with luteinizing hormone-releasing hormone agonist.
abstract: We report a case of a 28-year-old woman who had received 2 months of intranasal buserelin (a luteinizing hormone-releasing hormone agonist; LH-RH agonist) therapy for presumed uterine leiomyomata. In addition to no reduction of the tumor size evaluated by sonography, heavy vaginal bleeding and abdominal pain recurred and worsened during the therapy. Pathological examination of the myomectomy and hysterectomy specimens revealed leiomyosarcomas coexistent with cellular, atypical, and classical leiomyomata. We suggest that this is a case of leiomyosarcomas arising in preexisting leiomyomata rather than de novo from the smooth muscle fibers of the myometrium. Furthermore, the potential of LH-RH, agonist therapy to delay the surgical treatment of an unsuspected leiomyosarcoma is high-lighted. Close monitoring of the treatment response by improvement of clinical symptoms and sonographic assessment of tumor size may be helpful in early diagnosis of an underlying malignant tumor.
authors.affiliation: Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Lee
authors.forename: C C
authors.initials: CC
authors.lastname: Tzeng
authors.forename: C Y
authors.initials: CY
authors.lastname: Chou
mesh_terms: D000328:Adult; D002064:Buserelin / Q000627:therapeutic use*; D004967:Estrogens / Q000378:metabolism; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D018231:Leiomyomatosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D007890:Leiomyosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008197:Lymph Node Excision; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D010388:Pelvis; D014592:Uterine Hemorrhage / Q000209:etiology; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D004967:Estrogens; D002064:Buserelin