Correlation between DNA ploidy and clinical features in smooth muscle tumors of the gastrointestinal tract.
Paraffin-embedded tissue samples from 51 surgically resected, gastrointestinal smooth muscle tumors (10 leiomyomas, 5 leiomyoblastomas and 36 leiomyosarcomas) were assayed for nuclear DNA content, and the results were examined for correlation with clinico-pathological variables (tumor size, cellularity and mitosis) and prognosis. Twenty-four (47%) of the 51 tumors, consisting of 3 (30%) of the 10 leiomyomas, 2 (40%) of the 5 leiomyoblastomas and 19 (53%) of the 36 leiomyosarcomas, were identified as aneuploid. A close correlation was found between the mitotic index and the tumor size (<cc> = 0.528; P < 0.001). The DNA ploidy pattern of the leiomyosarcoma was closely correlated with the patient survival periods (P = 0.06). The estimated median survival period was 73 months for patients with diploid tumors, and 51 months for those with aneuploid tumors. The 10-year survival rate for aneuploid tumors was lower than that for diploid tumors (P < 0.001). The measurement of DNA content may provide an index of prognostic value in gastrointestinal leiomyosarcomas.
Kimura
H
H
Department of Surgery II, School of Medicine, Kanazawa University, Japan.
Yonemura
Y
Y
Kadoya
N
N
Kosaka
T
T
Miwa
K
K
Miyazaki
I
I
Sawa
T
T
Yoshimitsu
S
S
Nishida
Y
Y
Kamata
T
T
D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007889:Leiomyoma / Q000235:genetics / Q000473:pathology; D018230:Leiomyoma, Epithelioid / Q000235:genetics / Q000473:pathology; D007890:Leiomyosarcoma / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth; D011003:Ploidies
D004273:DNA, Neoplasm