Effect of gamma-irradiated carbohydrates on isolated synaptic membranes.
The effect of gamma-irradiated solutions of carbohydrates, mainly glucose, upon Na+, K(+)-ATPase and lipid peroxidation in rat brain synaptosomal membranes was studied. The membrane damage by irradiated glucose was enhanced in the presence of Fe2+ and was diminished when a free-radical scavenger (BHT) or metal chelators (EDTA, EGTA) were present. It is suggested that a key element in the free-radical membrane damage by irradiated carbohydrates is an Fe(2+)-complex of some species of the radiolysis products. Participation of radiotoxins of carbohydrate origin in radiobiological effects is discussed.
Kaler
G V
GV
Institute of Photobiology, Academy of Sciences of Belarus, Minsk.
Lyskova
T I
TI
Shadyro
O I
OI
Samoilenko
S G
SG
Edimecheva
I P
IP
Aksentsev
S L
SL
Konev
S V
SV
D000818:Animals; D004492:Edetic Acid / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D005609:Free Radicals; D005720:Gamma Rays; D005947:Glucose / Q000528:radiation effects*; D006861:Hydrogen Peroxide / Q000633:toxicity; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000528:radiation effects; D013570:Synaptic Membranes / Q000528:radiation effects*
D005609:Free Radicals; D004533:Egtazic Acid; D004492:Edetic Acid; D006861:Hydrogen Peroxide; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose