[Effects of different concentrations of an inhaled anesthetic agent, sevoflurane on sympatho-adrenal medullary functions in rats].
Effects of different inspiratory concentrations of an inhaled anesthetic agent, sevoflurane on efferent activities of the adrenal sympathetic nerve and adrenal catecholamine secretion were examined using rats either under the resting condition or during noxious mechanical stimulation of a hindpaw. Under the resting condition, an increase in the inspiratory concentration of sevoflurane from 2.1% to 4.2% caused a gradual decrease in the adrenal nerve activity and the catecholamine secretion. When noxious mechanical stimulation was applied to a hindpaw by pinching, both the adrenal nerve activity and adrenaline secretion increased, and the responses were attenuated dose-dependently by sevoflurane concentration of between 2.1% and 4.2%. Noradrenaline secretion was unchanged during the pinching stimulation throughout the administration of sevoflurane 2.1-4. 2%.
Nagayama
T
T
Department of Anesthesia, Tokyo Metropolitan Geriatric Hospital.
Meguro
K
K
Kurosawa
M
M
Sato
A
A
D000313:Adrenal Medulla / Q000294:innervation* / Q000378:metabolism; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000378:metabolism; D004987:Ethers / Q000494:pharmacology*; D008297:Male; D008738:Methyl Ethers; D009638:Norepinephrine / Q000378:metabolism; D010812:Physical Stimulation; D051381:Rats; D017208:Rats, Wistar; D000077149:Sevoflurane; D013564:Sympathetic Nervous System / Q000187:drug effects*
D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D009638:Norepinephrine; D004837:Epinephrine