Thyroid functioning during treatment for depression.
Thirty-nine unipolar depressed patients were treated, after a washout period of seven days in a double blind study with either moclobemide, placebo or amitriptyline, for 42 days. The psychopathological assessment and HRSD were done on seven day intervals and thyroid analysis was done on 14 day intervals. At the end of therapy, the levels of T4 and fT4 decreased significantly in the responders if amitriptyline was used, and non-significantly if placebo or moclobemide were used. The T4 and fT4 values of the non-responders increased non-significantly. The weight change was minimal and non-significant.
Kusalic
M
M
Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Engelsmann
F
F
Bradwejn
J
J
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D010555:Personality Inventory; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood*
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D013963:Thyroid Hormones; D000639:Amitriptyline; D020912:Moclobemide