title: Hypomagnesemia following correction of metabolic acidosis: a case of hungry bones.
abstract: Severe symptomatic hypomagnesemia (0.15 mmol/L [0.3 mEq/L]) and hypocalcemia (1.47 mmol/L [5.9 mg/dL]) occurred in a 4-week-old infant coincidental with correction of a severe renal tubular acidosis with alkali therapy. The patient had no evidence of gastrointestinal abnormality and magnesium (Mg) intake was adequate for age and weight. Extreme renal conservation of Mg was observed, supporting the presence of Mg depletion. We suggest that Mg depletion in this infant occurred due to acidosis-induced bone demineralization and that symptomatic hypomagnesemia was precipitated by rapid remineralization accompanying correction of systemic acidosis. This patient represents a novel case of hungry bone syndrome (HBS). Since HBS has not been described previously in patients with acidosis undergoing therapy, several other factors may have contributed to this patient's severe hypomagnesemia, namely, prematurity, twin status, severity of acidosis, rapidity of correction of acidosis, catch-up growth and calcium supplementation. Clinicians should be vigilant for HBS in infants with severe acidosis undergoing alkali therapy.
authors.affiliation: Department of Pediatrics, Allegheny General Hospital, Pittsburgh PA 15212-4772.
authors.forename: L S
authors.initials: LS
authors.lastname: Frisch
authors.forename: F
authors.initials: F
authors.lastname: Mimouni
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications / Q000188:drug therapy*; D001639:Bicarbonates / Q000627:therapeutic use*; D002113:Calcification, Physiologic; D002118:Calcium / Q000097:blood; D004200:Diseases in Twins; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008275:Magnesium Deficiency / Q000209:etiology*; D008297:Male; D010758:Phosphorus / Q000097:blood
chemical_list: D001639:Bicarbonates; D010758:Phosphorus; D002118:Calcium