Low predictive value of c-ANCA and anti-alpha-granule antibody for vasculitis in Hong Kong.
One thousand sera, not previously tested for ANCA, were assayed for C-ANCA and anti-alpha-granule antibody. There was low concordance (23%) between the two assays in terms of positivity. Each assay gave a positive predictive value for systemic vasculitis excluding SLE and other connective-tissue diseases) of not more than 20%.
Lawton
J W
JW
Department of Pathology, University of Hong Kong.
Lee
S S
SS
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D003594:Cytoplasmic Granules / Q000276:immunology*; D006723:Hong Kong; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D009504:Neutrophils / Q000648:ultrastructure*; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G