title: Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.
authors.affiliation: Dept. Oncology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Peters
authors.forename: K
authors.initials: K
authors.lastname: Hoekman
authors.forename: C J
authors.initials: CJ
authors.lastname: van Groeningen
authors.forename: C L
authors.initials: CL
authors.lastname: van der Wilt
authors.forename: K
authors.initials: K
authors.lastname: Smid
authors.forename: S
authors.initials: S
authors.lastname: Meijer
authors.forename: H M
authors.initials: HM
authors.lastname: Pinedo
mesh_terms: D001665:Binding Sites; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005468:Fluorodeoxyuridylate / Q000378:metabolism; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D002955:Leucovorin / Q000494:pharmacology*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
chemical_list: D005468:Fluorodeoxyuridylate; D013940:Thymidylate Synthase; D002955:Leucovorin; D005472:Fluorouracil