Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12-->q22.
Latent transforming growth factor beta 1-binding protein (LTBP1) is an important component of the large latent TGF-beta 1 complex. It plays a role in the assembly and secretion of the latent TGF-beta 1. In this paper we have used a cDNA probe for LTBP1 to determine the chromosomal localization of the human gene. Using a panel of well-defined human x rodent somatic cell hybrid lines, LTBP1 could be assigned to chromosome 2. Further sublocalization of the gene to 2p12-->q22 was achieved using three hybrid lines which contain partially over-lapping fragments of chromosome 2.
Stenman
G
G
Department of Oral Pathology, University of Göteborg, Sweden.
Sahlin
P
P
Olofsson
A
A
Geurts van Kessel
A
A
Miyazono
K
K
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D006822:Hybrid Cells; D047908:Intracellular Signaling Peptides and Proteins; D053779:Latent TGF-beta Binding Proteins
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C509032:LTBP1 protein, human; D053779:Latent TGF-beta Binding Proteins