title: A masked prospective evaluation of outcome parameters for cytomegalovirus-related retinal detachment surgery in patients with acquired immune deficiency syndrome.
abstract: OBJECTIVE
  The management of cytomegalovirus (CMV)-related rhegmatogenous retinal detachments in patients with acquired immune deficiency syndrome (AIDS) has been the subject of recent attention and controversy because of the high degree of variability in visual outcome, as well as significant differences in the reported incidence of profound postoperative optic atrophy. This study was designed to evaluate the various parameters affecting postoperative visual outcome, and to quantitate the degree of postoperative optic disc pallor.
  
  
  METHODS
  The results of 65 consecutive surgeries for CMV-related retinal detachments in 51 patients with AIDS were prospectively studied. Postoperative vision, survival, optic disc pallor, and retinitis extent were analyzed. Serial photographs of optic discs underwent masked evaluation.
  
  
  RESULTS
  Mean postoperative survival was 30 weeks (range, 2-146 weeks). Mean best postoperative visual acuity was 20/66 (range, 20/20-2/200) and mean final postoperative visual acuity was 20/100 (range, 20/25-no light perception). Analysis of visual outcome for eyes with no macular or papillo-macular retinitis showed a best postoperative visual acuity of 20/60 (range, 20/25-2/200) and mean final postoperative visual acuity of 20/80 (range, 20/25-no light perception). Postoperative vision was not affected by the presence of a preoperative macular detachment, with both groups (macula on or off detachments), achieving a best postoperative visual acuity of 20/60 in the absence of macular retinitis. Mild postoperative optic disc pallor was observed in 30% of surgical eyes at the final postoperative visit, and moderate pallor was noted in 13%. The mean degree of optic disc pallor was not different from the degree of optic disc pallor seen in fellow, nonsurgical eyes with CMV retinitis (surgical versus fellow nonsurgical eyes, 29% +/- 23% versus 26% +/- 30%; P = 0.64).
  
  
  CONCLUSIONS
  In this largest reported series of reattachment surgery for CMV-related retinal detachments, patients are experiencing increased postoperative survival, good vision, and relative optic nerve health.
authors.affiliation: Department of Ophthalmology, University of California, San Diego, La Jolla 92093-0946.
authors.forename: B D
authors.initials: BD
authors.lastname: Kuppermann
authors.forename: M
authors.initials: M
authors.lastname: Flores-Aguilar
authors.forename: J I
authors.initials: JI
authors.lastname: Quiceno
authors.forename: E V
authors.initials: EV
authors.lastname: Capparelli
authors.forename: L
authors.initials: L
authors.lastname: Levi
authors.forename: D
authors.initials: D
authors.lastname: Munguia
authors.forename: W R
authors.initials: WR
authors.lastname: Freeman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000473:pathology; D000328:Adult; D017726:Cytomegalovirus Retinitis / Q000150:complications* / Q000473:pathology; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology; D011446:Prospective Studies; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome; D014792:Visual Acuity