Pro- and anti-inflammatory cytokines in primary systemic vasculitis.
The expression of cytokines that are potentially involved in the pathogenesis of vasculitis was studied in patients with primary systemic vasculitis (PSV). In extension of earlier reports, we detected an overexpression of transforming growth factor beta (TGF beta), interleukin 6 (IL6), and interleukin 8 (IL8), indicating that the whole cytokine cascade is activated to a significant extent in PSV.
Kekow
J
J
Department of Clinical Rheumatology, Medical University at Lübeck, Germany.
Szymkowiak
C H
CH
Sticherling
M
M
Schröder
J M
JM
Christophers
E
E
Gross
W L
WL
D015267:Churg-Strauss Syndrome / Q000097:blood; D016207:Cytokines / Q000097:blood* / Q000235:genetics; D015870:Gene Expression; D014890:Granulomatosis with Polyangiitis / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D016209:Interleukin-8 / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000097:blood; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D014657:Vasculitis / Q000097:blood*
D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta