title: Effect of various non-hepatotoxic compounds on urinary and liver taurine levels in rats.
abstract: Administration of compounds which alter protein synthesis or sulphur amino acid metabolism in rats results in changes in the excretion of urinary taurine. Treatment with diethylmaleate (DEM) or phorone, which will deplete glutathione (GSH), reduces taurine excretion, whereas treatment with buthionine sulphoximine (BSO), which will inhibit glutathione synthesis, increases taurine excretion. Treatment with cycloheximide, an inhibitor of protein synthesis, increases taurine excretion, whereas pretreatment with phenobarbital, which will increase protein synthesis, decreases taurine excretion. Administration of agents which damage organs other than the liver such as the kidney, heart and testes, does not increase urinary taurine.
authors.affiliation: Department of Toxicology, School of Pharmacy, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Waterfield
authors.forename: J A
authors.initials: JA
authors.lastname: Turton
authors.forename: M D
authors.initials: MD
authors.lastname: Scales
authors.forename: J A
authors.initials: JA
authors.lastname: Timbrell
mesh_terms: D000818:Animals; D003401:Creatine / Q000652:urine; D004798:Enzymes / Q000097:blood; D005978:Glutathione / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013654:Taurine / Q000378:metabolism* / Q000652:urine; D014280:Triglycerides / Q000378:metabolism
chemical_list: D004798:Enzymes; D011506:Proteins; D013438:Sulfhydryl Compounds; D014280:Triglycerides; D013654:Taurine; D005978:Glutathione; D003401:Creatine