[The correlation of atrial natriuretic peptide values with those of renin, angiotensin and aldosterone in hypertension patients below and above 50].
A comparison of ANP and RAA. In 6 healthy subjects < 50 y, 5 healthy subjects > 50 y, 44 patients with essential hypertension < 50 y, and 41 patients with essential hypertension > 50 y, was performed. ANP values in healthy subjects < 50 y, were means = 44 +/- 7 PG/ml, and means = 87.33 +/- 14 PG/ml in those > 50 y. (P < 0.01). 80% of hypertensives < 50 y, had normal values of ANP (means = 63.8 +/- 10 PG/ml) and 20% high values (means = 131 +/- 6 PG/ml) (P < 0.001). 70% of hypertensives > 50 y, had high ANP values (means = 260 +/- 114 PG/ml) and 30% normal values (means = 75 +/- 5 PG/ml) (P < 0.001). Values for RAA were low or normal in 96% of cases with high ANP values (P < 0.001), and 100% of the cases with high RAA values, had low or normal ANP values. (P < 0.0001). This correlation had an statistically significant value for groups over 50 years (high ANP values, low RAA values) (P < 0.001) and high RAA values with low or normal ANP values in groups below 50 y (P < 0.001). We observed no significant correlation between ANP values and LVH. According to our results, essential hypertensives < 50 y, have low or normal ANP values in the majority of cases (P < 0.001). Essential hypertensives over 50 y. Have high ANP values also in the majority of cases (P < 0.001). As previously reported, an inversely proportional ratio between RAA and ANP was found in our study. The significance of ANP in regulating blood pressure in the elderly is considered.
González Carmona
V M
VM
Hospital de Cardiología, Centro Médico Nacional Siglo XXI, IMSS, México, D.F.
García
R
R
Camacho
P
P
Jerjes Sánchez
C
C
Arévila
N
N
Hernández
H
H
Nieto Castillo
S
S
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000450:Aldosterone / Q000097:blood*; D000704:Analysis of Variance; D000804:Angiotensin II / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011863:Radioimmunoassay; D012016:Reference Values; D012083:Renin / Q000097:blood*
D000804:Angiotensin II; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin
Correlación de valores de péptido natriurético auricular con los de renina, angiotensina y aldosterona en pacientes hipertensos menores y mayores de 50 años.