Treatment of Wegener's granulomatosis with intravenous immunoglobulin.
We report about the treatment of eight patients with Wegener's granulomatosis and one patient with systemic pANCA-associated vasculitis with a single course of high-dose intravenous immunoglobulin (IVIG). In 5 of 9 patients (55%) this resulted in significant clinical improvement, in two patients a decrease of the ANCA-titre was seen.
Richter
C
C
Dept. of Rheumatology, Medical University of Lübeck, Germany.
Schnabel
A
A
Csernok
E
E
Reinhold-Keller
E
E
Gross
W L
WL
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000276:immunology; D014657:Vasculitis / Q000276:immunology / Q000628:therapy
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D012697:Serine Endopeptidases; D053146:Myeloblastin