title: Antimicrobial compounds from Petalostemum purpureum.
abstract: EtOH extracts of Petalostemum purpureum demonstrated antimicrobial activity against bacteria and fungi. Bioassay-directed fractionation led to the isolation of petalostemumol [1] as the active constituent. Its structure was determined by a single crystal X-ray diffraction analysis. A minor component designated petalostemumol G [3] is believed to be an artifact of the isolation procedure. Its structure was confirmed by a single crystal X-ray analysis of its pentamethylether 2. A number of derivatives of 1 and 3, including the Me- and benzylethers and acetates, were prepared.
authors.affiliation: Department of Pharmacognosy, University of Mississippi, University 38677.
authors.forename: C D
authors.initials: CD
authors.lastname: Hufford
authors.forename: Y
authors.initials: Y
authors.lastname: Jia
authors.forename: E M
authors.initials: EM
authors.lastname: Croom
authors.forename: I
authors.initials: I
authors.lastname: Muhammed
authors.forename: A L
authors.initials: AL
authors.lastname: Okunade
authors.forename: A M
authors.initials: AM
authors.lastname: Clark
authors.forename: R D
authors.initials: RD
authors.lastname: Rogers
mesh_terms: D000107:Acetylation; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002853:Chromatography, Liquid; D018360:Crystallography, X-Ray; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005419:Flavonoids; D010936:Plant Extracts; C085392:petalostemunol