title: Chronic gastritis and Helicobacter pylori in digestive form of Chagas' disease.
abstract: Patients with the digestive form of Chagas' disease frequently present chronic gastritis. As the microorganism Helicobacter pylori is now accepted as the most common cause of human chronic gastritis, the present work was undertaken to verify a possible relationship between the presence of this bacterium and inflammatory changes of antral mucosa in chagasic patients. Seventeen chagasics, with megaesophagus and or megacolon were studied. Fragments from two different regions of antral mucosa were obtained by endoscopy, fixed in 4% neutral formaldehyde and embedded in paraffin. The sections were stained by haematoxylin and eosin for histology analysis, and by carbolfuchsin for H. pylori identification. H. pylori was found in 16 (94.1%) chagasic patients, all of them presenting chronic gastritis. Superficial gastritis was seen in 9 (52.9%) while atrophic gastritis was present in 8 (47.1%) patients. H. pylori was present on gastric mucosa of 8 (100%) patients with atrophic gastritis and of 8 (88.8%) patients with superficial gastritis. We concluded that the microorganism H. pylori should be considered a possible factor connected with the etiopathogenesis of chronic superficial and atrophic gastritis frequently observed in patients with the digestive form of Chagas' disease.
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, SP, Brasil.
authors.forename: A J
authors.initials: AJ
authors.lastname: Barbosa
authors.forename: D M
authors.initials: DM
authors.lastname: Queiroz
authors.forename: A M
authors.initials: AM
authors.lastname: Nogueira
authors.forename: M J
authors.initials: MJ
authors.lastname: Roquette Reis
authors.forename: E N
authors.initials: EN
authors.lastname: Mendes
authors.forename: G A
authors.initials: GA
authors.lastname: Rocha
authors.forename: L M
authors.initials: LM
authors.lastname: Romanello
authors.forename: L E
authors.initials: LE
authors.lastname: Troncon
mesh_terms: D000328:Adult; D014355:Chagas Disease / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000382:microbiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged