[The role of disruption of lipid metabolism in mechanisms of the hepatotoxic effects of cisplatin].
Distinct alterations in the metabolism of lipids and phospholipids as well as activation of lipid peroxidation in liver tissue were detected in mice after administration of a new antitumoral drug cisplatin at a dose of LD50 (13.5 mg/kg) or after the course treatment within 5 days using 1/5 LD50. Content of malonic dialdehyde, diene conjugates and Schiff bases was increased, while the phospholipid composition was altered and concentration of membrane-toxic ingredients was increased. When the effects of cisplatin, administered at a dose of LD50 and during the course treatment, were analyzed more pronounced impairments of lipid metabolism were found during 7-15 days in mice treated with the drug at LD50. However, the drug toxic effect was manifested earlier during the course of treatment and in some cases it maintained for a long time (up to 30 days of the experiment). The data obtained suggest that correction of the cytostatic-induced impairments in liver tissue functions may be carried out by means of the anti-radical drugs.
Vetoshkina
T V
TV
Dubskaia
T Iu
TIu
D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D007928:Lethal Dose 50; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D012545:Schiff Bases / Q000378:metabolism
D012545:Schiff Bases; D008315:Malondialdehyde; D002945:Cisplatin
Rol' narusheniĭ metabolizma lipidov v mekhanizmakh gepatotoksicheskikh éffektov tsisplatina.