Primary antiphospholipid antibody syndrome and cerebral ischemia: report on acute intervention in two cases and literature review with emphasis on therapeutic options.
In two patients with primary antiphospholipid antibody syndrome and acute cerebrovascular ischemic events, local intraarterial fibrinolysis and intravenous heparin therapy, respectively, resulted in a limitation of persisting neurological deficits. On the basis of the 35 case reports available a combination of anticoagulation with warfarin, plus immunosuppression with steroids and/or cyclophosphamide or azathioprine, appears to be the best treatment to prevent further cerebral ischemic events. The therapeutic options are reviewed and discussed.
Braune
S
S
Neurologische Universitätsklinik Freiburg, Germany.
Siekmann
R
R
Vaith
P
P
Lücking
C H
CH
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000188:drug therapy / Q000628:therapy*; D001379:Azathioprine / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005342:Fibrinolysis; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin; D003520:Cyclophosphamide; D006493:Heparin; D001379:Azathioprine