title: Miconazole chewing gum for treatment of chronic oral candidosis.
abstract: A chewing gum containing the antifungal drug miconazole may be convenient for topical treatment of oral candidosis. Therefore a trial was performed to examine the effect and tolerance of miconazole chewing gum in comparison with miconazole gel in the treatment of oral candidosis. The study group consisted of 32 patients with oral candidosis harboring yeasts, predominantly Candida spp. Half of the patients chewed one piece of chewing gum (dose: 3.6 mg of miconazole) four times daily; the other half dispersed a 2% gel (dose: 50 mg of miconazole) in the oral cavity four times daily. After 6 wk of treatment, there was no clinical evidence of yeast infection in either of the two groups. No significant differences between the two groups were found in clinical, mycologic, and cytologic investigations conducted after 3 and 6 wk of treatment or at the follow-up examination 4 wk after termination of the treatment. The results indicate that miconazole released from chewing gum is as effective as miconazole gel. The chewing gum reduced the dosage of miconazole for treatment of oral candidosis, and the patients approved the chewing gum as a pleasant medicament.
authors.affiliation: Department of Oral Medicine and Oral Surgery, University Hospital (Rigshospitalet), Copenhagen, Denmark.
authors.forename: J L
authors.initials: JL
authors.lastname: Rindum
authors.forename: P
authors.initials: P
authors.lastname: Holmstrup
authors.forename: M
authors.initials: M
authors.lastname: Pedersen
authors.forename: M R
authors.initials: MR
authors.lastname: Rassing
authors.forename: K
authors.initials: K
authors.lastname: Stoltze
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000287:Administration, Topical; D002180:Candidiasis, Oral / Q000188:drug therapy*; D002638:Chewing Gum; D016009:Chi-Square Distribution; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008825:Miconazole / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D002638:Chewing Gum; D005782:Gels; D008825:Miconazole