title: [The noninvasive determination of resting myocardial blood flow in patients using 82 Rb in comparison with the argon method].
abstract: Resting myocardial blood flow in absolute units was determined in 11 patients without known heart disease using dynamic PET with 82Rb. Based on a modified Fick's approach to measuring myocardial blood flow, originally developed and validated in canine studies by Herrero and coworkers (Circulation 1990; 82: 1377-86), a global flow value of 0.60 +/- 0.10 ml/min/gr myocardium (MV +/- SD, N = 11) was obtained. With the exception of the apex, segmental blood flow was not significantly different in 12 left ventricular myocardial segments, indicating homogenous myocardial blood flow distribution. In 5 patients global myocardial blood flow was determined simultaneously both by 82Rb PET and argon as inert gas method. 82Rb flow did not differ significantly from argon flow (0.60 +/- 0.05 vs. 0.68 +/- 0.15, MV +/- SD, N.S.). These results show that correct quantitation of resting myocardial blood flow with dynamic 82Rb PET is feasible also in patients.
authors.affiliation: Radiologische Klinik III, Universitätsklinikum Ulm, FRG.
authors.forename: S N
authors.initials: SN
authors.lastname: Reske
authors.forename: M M
authors.initials: MM
authors.lastname: Henrich
authors.forename: E
authors.initials: E
authors.lastname: Mate
authors.forename: R
authors.initials: R
authors.lastname: Weller
authors.forename: G
authors.initials: G
authors.lastname: Glatting
authors.forename: S
authors.initials: S
authors.lastname: Grimmel
authors.forename: R
authors.initials: R
authors.lastname: Weismüller
authors.forename: J
authors.initials: J
authors.lastname: Stollfuss
authors.forename: V
authors.initials: V
authors.lastname: Hombach
mesh_terms: D000328:Adult; D001128:Argon; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012414:Rubidium Radioisotopes; D014055:Tomography, Emission-Computed
chemical_list: D012414:Rubidium Radioisotopes; D001128:Argon
vernacular_title: Nichtinvasive Bestimmung der myokardialen Ruhedurchblutung mit 82Rb PET bei Patienten im Vergleich zur Argon-Methode.