Effect of a novel antifolate, N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523), on growth of H35 rat hepatoma and HEPG2 human hepatoma cells.
Rhee
M S
MS
Wadsworth Center for Laboratories and Research, NYS Department of Health, Albany 12201.
Galivan
J
J
Tyobeka
E M
EM
Sherman
M L
ML
Rosowsky
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D006528:Carcinoma, Hepatocellular; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004273:DNA, Neoplasm / Q000187:drug effects; D003857:Deoxyuridine / Q000378:metabolism; D005493:Folic Acid Antagonists / Q000633:toxicity*; D005998:Glycine / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms; D009952:Ornithine / Q000031:analogs & derivatives* / Q000633:toxicity; D011622:Pterins / Q000633:toxicity*; D011687:Purines / Q000378:metabolism; D051381:Rats; D013938:Thymidine Monophosphate / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D005493:Folic Acid Antagonists; D011622:Pterins; D011687:Purines; C085590:N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine; D013938:Thymidine Monophosphate; D009952:Ornithine; D005998:Glycine; D003857:Deoxyuridine