Antitumor efficacy of classical non-polyglutamylatable antifolates that inhibit dihydrofolate reductase.
Abraham
A
A
University of South Alabama, Mobile 36688.
Nair
M G
MG
McGuire
J J
JJ
Galivan
J
J
Kisliuk
R L
RL
Vishnuvajjala
B R
BR
D000630:Aminopterin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D004354:Drug Screening Assays, Antitumor; D005493:Folic Acid Antagonists / Q000633:toxicity*; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008727:Methotrexate / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; C085593:gamma-methylene-10-deazaaminopterin; C085594:gamma-methylene-10-ethyl-10-deazaaminopterin; D000630:Aminopterin; D008727:Methotrexate