Dose-volume effects in the spinal cord.
Experimental data on dose-volume relationships for the spinal cord are now available for a variety of animal models (monkey, dog, pig, rat). Most studies show a marginal volume effect for cord lengths longer than 1 cm, but a steep increase in tolerance doses for irradiated lengths of less than 1 cm. From a comparison of several theoretical models with available clinical/experimental data it can be concluded that there is at present no need for a further expansion of models, but a great need of reliable data.
van der Kogel
A J
AJ
Institute of Radiotherapy, University of Nijmegen, The Netherlands.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D013116:Spinal Cord / Q000528:radiation effects*