Interstitial pneumonitis possibly due to mitoxantrone.
A 41-year-old patient with chronic myelogenous leukemia in the accelerated phase was treated with mitoxantrone. She developed pyrexia 7 days after receiving the third administration of mitoxantrone. After 3 more days, she experienced dry cough and dyspnea. Bilateral fine crackles were audible, but no signs of heart failure were found. A chest X-ray film revealed diffuse reticulogranular infiltrates bilaterally. An increase in the prednisolone dosage led to an improvement. Specimens of the bronchoalveolar lavage revealed an increase in CD4-/CD8- lymphocytes. The peripheral lymphocytes also expressed neither CD4 nor CD8. Specimens of a transbronchial lung biopsy disclosed thickening of the alveolar wall with infiltration of lymphoid cells.
Matsukawa
Y
Y
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Takeuchi
J
J
Aiso
M
M
Hagiwara
T
T
Hayama
T
T
Ohshima
T
T
Horie
T
T
Kitami
Y
Y
D000328:Adult; D005260:Female; D006801:Humans; D015465:Leukemia, Myeloid, Accelerated Phase / Q000188:drug therapy; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008942:Mitoxantrone / Q000009:adverse effects*
D008942:Mitoxantrone