[A trial to produce an inactivated Lassa fever vaccine].
A single and double immunization of Papio hamadryas monkeys with an inactivated concentrated purified adsorbed preparation of Lassa virus in doses of 0.5-1.0 and 1.1-2.1 mg by protein, respectively, protected the animals against the development of the disease and occurrence of viremia after an intramuscular challenge with 0.4 PFU dose. Upon aerogenic infection of monkeys protection of 50% of the animals was achieved by a single immunization with the inactivated preparation in a dose 1.1 mg by protein.
Krasnianskiĭ
V P
VP
Potryvaeva
N V
NV
Borisevich
I V
IV
Gradoboev
V N
VN
Pashanina
T P
TP
Pshenichnov
V A
VA
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D003168:Complement Fixation Tests; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D007114:Immunization; D007835:Lassa Fever / Q000276:immunology / Q000401:mortality / Q000517:prevention & control; D007836:Lassa virus / Q000276:immunology* / Q000302:isolation & purification; D009500:Neutralization Tests; D010215:Papio; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000276:immunology / Q000302:isolation & purification; D014765:Viral Vaccines / Q000276:immunology / Q000302:isolation & purification*; D014776:Virus Cultivation
D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
Opyt polucheniia inaktivirovannoĭ vaktsiny likhoradki Lassa.