title: Use of microwaves for rapid fixation of tissues in vivo.
abstract: Accurate knowledge of the concentration in the central nervous system of neurochemicals undergoing rapid enzymatic destruction or synthesis is sparse because of the difficulty in stopping the rapid reactions while causing only minimal adverse changes in the neurochemistry and structure. Microwave heating can be effectively used to rapidly stop enzyme activity in the central nervous system with minimal adverse changes. This rapid inactivation of the enzymes increases the validity of the sample that is taken for analysis of the concentration of the enzyme's substrate.
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78284-7764.
authors.forename: W B
authors.initials: WB
authors.lastname: Stavinoha
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D008872:Microwaves; D016707:Tissue Fixation / Q000379:methods*