The role of permeability to calcium in the formation of the level of local blood supply of the cerebral cortex.
The features of the effect of some calcium antagonists on local brain blood flow in the sensorimotor, auditory, and visual regions of the cerebral cortex of rabbits have been investigated in chronic experiments on rabbits using the hydrogen clearance technique, and the hydrational state of the tissue was investigated by means of impedometry. It was established that during the intravenous administration of various calcium antagonists there are individual features in the effects on particular functional zones of the cerebral cortex of rabbits. The data obtained permitted the identification of regions of mainly increased local brain blood flow during the use of the calcium antagonists we were investigating. The results of three-frequency impedometry permit a judgment regarding the changes in the degree of hydration of brain tissue during the use of calcium antagonists.
Gurbanov
I A
IA
Department of Pharmacology, Sanitary-Hygiene Medical Institute, Saint Petersburg.
D'yachuk
G I
GI
Maksimuk
V F
VF
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000254:growth & development*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005444:Flunarizine / Q000494:pharmacology; D011817:Rabbits
D002121:Calcium Channel Blockers; D005444:Flunarizine; D002118:Calcium