title: Interaction between beta-blockers and contrast media during intracoronary administration in rabbit heart.
abstract: The effects of ionic, meglumine sodium diatrizoate (Urografin 76) and nonionic, iohexol contrast media were examined in the absence and presence of propranolol, a beta-blocker having nonspecific membrane stabilizing action and atenolol, a beta-blocker lacking nonspecific membrane stabilizing action on Langendorff-perfused rabbit hearts. Contrast medium, 0.7 ml, was injected into the aortic root in the absence and presence of 10(-7) and 10(-5) M beta-blocker to observe the changes in resting tension, force of contraction, rate of contraction, heart rate and PR interval. Beta-blockers and contrast media interact in affecting myocardial contractility, heart rate and atrioventricular conduction. The interaction is milder when the beta-blocker lacks membrane stabilizing activity and the contrast medium is nonionic.
authors.affiliation: Department of Cardiology, Media School of Ankara University, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Salbaş
authors.forename: G
authors.initials: G
authors.lastname: Akgün
authors.forename: G
authors.initials: G
authors.lastname: Pamĭr
authors.forename: T
authors.initials: T
authors.lastname: Gürel
mesh_terms: D000818:Animals; D001262:Atenolol / Q000008:administration & dosage / Q000494:pharmacology*; D001283:Atrioventricular Node / Q000187:drug effects; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects*; D006327:Heart Block / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D007267:Injections; D007472:Iohexol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D003974:Diatrizoate Meglumine; D007472:Iohexol; D001262:Atenolol; D011433:Propranolol