title: Effects of snuff on regional blood flow to the cheek and tongue of anesthetized dogs.
abstract: Regional blood flow to the cheek and tongue of anesthetized dogs was measured before and after application of six different doses of snuff (3.12 to 100 mg/kg body weight) to the right cheek. Dose-independent vasodilation was observed at the site of application, whereas dose-dependent vasoconstriction was observed contralaterally. Aortic, central venous, and ventricular pressures were significantly increased (p < 0.05) at the higher doses. Plasma nicotine concentrations increased stepwise with dose.
authors.affiliation: Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth.
authors.forename: K D
authors.initials: KD
authors.lastname: Huckabee
authors.forename: R T
authors.initials: RT
authors.lastname: Barnes
authors.forename: A G
authors.initials: AG
authors.lastname: Williams
authors.forename: W L
authors.initials: WL
authors.lastname: Fan
authors.forename: H F
authors.initials: HF
authors.lastname: Downey
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002496:Central Venous Pressure / Q000187:drug effects; D002610:Cheek / Q000098:blood supply; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006940:Hyperemia / Q000139:chemically induced*; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply*; D009538:Nicotine / Q000097:blood; D010947:Plants, Toxic; D010992:Plethysmography, Impedance; D012039:Regional Blood Flow / Q000187:drug effects; D014030:Tobacco, Smokeless / Q000633:toxicity*; D014059:Tongue / Q000098:blood supply; D014661:Vasoconstriction; D014664:Vasodilation
chemical_list: D009538:Nicotine