title: The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships.
authors.affiliation: Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Jansen
authors.forename: G R
authors.initials: GR
authors.lastname: Westerhof
authors.forename: J H
authors.initials: JH
authors.lastname: Schornagel
authors.forename: A L
authors.initials: AL
authors.lastname: Jackman
authors.forename: F T
authors.initials: FT
authors.lastname: Boyle
mesh_terms: D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists / Q000378:metabolism*; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D051379:Mice; D011799:Quinazolines / Q000737:chemistry / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists; D011799:Quinazolines; D011956:Receptors, Cell Surface; D013940:Thymidylate Synthase