The Mycobacterium bovis 32-kilodalton protein antigen induces human cytotoxic T-cell responses.
The 30-kDa protein (P32) is a mycobacterial secreted antigen which is homologous in Mycobacterium bovis and M. tuberculosis. In vitro, P32 induced T-cell proliferation. M. tuberculosis- or P32-stimulated T-cell lines lysed macrophages pulsed with P32 or M. tuberculosis, respectively. We conclude that P32 stimulates cytotoxic T cells specifically.
Munk
M E
ME
Department of Immunology, University of Ulm, Germany.
De Bruyn
J
J
Gras
H
H
Kaufmann
S H
SH
D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D001500:BCG Vaccine / Q000276:immunology / Q000302:isolation & purification; D001426:Bacterial Proteins / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008970:Molecular Weight; D009163:Mycobacterium bovis / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000942:Antigens, Bacterial; D001500:BCG Vaccine; D001426:Bacterial Proteins; C065036:antigen 85, Mycobacterium bovis