Anaesthetic phencyclidine, blocker of the ATP-sensitive potassium channels.
The double sucrose gap and patch-clamp studies revealed that phencyclidine blocked the ATP-sensitive K+ channel in isolated cardiac cells (half-maximal inhibition at approximately 20 microM; Hill coefficient approximately 1). 10 microM phencyclidine increased the inward Ca2+ current and blocked the outward K+ current in the frog auricle trabeculae. The phencyclidine effects on the frog auricle trabeculae and the isolated cardiac cells proved to be quite reversible.
Kokoz
Y M
YM
Laboratory of Functional Biochemistry, Russian Academy of Sciences, Pushchino, Moscow Region.
Alekseev
A E
AE
Povzun
A A
AA
Korystova
A F
AF
Peres-Saad
H
H
D000200:Action Potentials; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D004553:Electric Conductivity; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D010622:Phencyclidine / Q000494:pharmacology*; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000502:physiology; D011895:Rana ridibunda; D051381:Rats; D017208:Rats, Wistar
D015220:Calcium Channels; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D010622:Phencyclidine