title: Changes concurrent with initiation of abstinence from cocaine abuse.
abstract: In an exploration of changes that occur with initiation of cocaine abstinence, this study examined treatment outcomes in four domains--behavior (cocaine use), affect (depression), cognition (schematic self-representations), and psychophysiology (reactivity to drug cues). Nineteen patients initially entered this 8-week outpatient psychopharmacotherapy trial for the treatment of cocaine dependence. Thirteen completed treatment, and eleven maintained abstinence during the last four weeks of the study. In addition to a demonstrated change in their cocaine-using behavior, these "abstainers" reported reduced depression, increased congruency with "ideal" self-schemas, increased discrepancy with "addict" self-schemas, and generally more positive self-representations. In addition, "abstainers" reported reduced posttreatment craving in the presence of cocaine cues, but evidenced no change in physiological reactivity. Implications of these findings for research and treatment are discussed.
authors.affiliation: Department of Psychiatry, Yale University, New Haven, Connecticut.
authors.forename: S K
authors.initials: SK
authors.lastname: Avants
authors.forename: A
authors.initials: A
authors.lastname: Margolin
authors.forename: T R
authors.initials: TR
authors.lastname: Kosten
authors.forename: J L
authors.initials: JL
authors.lastname: Singer
mesh_terms: D000328:Adult; D001143:Arousal; D016642:Bupropion / Q000627:therapeutic use; D003042:Cocaine; D003863:Depression / Q000523:psychology / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D008297:Male; D010555:Personality Inventory; D012649:Self Concept; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D016896:Treatment Outcome
chemical_list: D016642:Bupropion; D003042:Cocaine