Synthesis and mitogenic activity of chiral lipopeptide WS1279 and its derivatives.
Optically active lipopeptide derivatives have been synthesized by the use of chiral glycerol derivatives. Lipopeptide WS1279 derivatives with (R)-glycerol moieties showed a higher mitogenic activity than those with the (S)-configuration. Various N-protected lipopeptide and N-deprotected derivatives showed increased mitogenic activity.
Kurimura
M
M
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Ochiai
A
A
Achiwa
K
K
D000595:Amino Acid Sequence; D008074:Lipoproteins / Q000138:chemical synthesis* / Q000494:pharmacology*; D008934:Mitogens / Q000138:chemical synthesis* / Q000494:pharmacology; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D008074:Lipoproteins; D008934:Mitogens; C065847:WS 1279