title: Nalmefene in the treatment of interstitial cystitis.
abstract: Nalmefene is a new narcotic antagonist that is structurally similar to naloxone and naltrexone. The drug is a long-acting oral agent that is a pure opiate antagonist without agonist activity. Nalmefene appears to be a safe and effective compound for the treatment of interstitial cystitis. Longer-term studies and Phase III randomized trials need to be completed to substantiate these encouraging findings.
authors.affiliation: Department of Urology, Mt. Sinai School of Medicine, New York, New York.
authors.forename: N N
authors.initials: NN
authors.lastname: Stone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003556:Cystitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D009292:Narcotic Antagonists; D009271:Naltrexone; C038981:nalmefene