Cocaine enhancement of the action of 5-hydroxytryptamine in rat cingulate cortex in vitro.
Intracellular recordings were made in vitro from pyramidal neurons in layer V of the anterior cingulate cortex of the rat. 5-Hydroxytryptamine (5-HT) reduced the amplitude of the excitatory postsynaptic potential; receptor-selective agonists and antagonists indicated that this resulted from activation of the 5-HT1B receptor. The action of 5-HT was enhanced by cocaine (300 nM-3 microM); 1 microM cocaine increased sensitivity to 5-HT about 10-fold. The results suggest that cocaine is similarly effective to potentiate the action of 5-HT in the prefrontal cortex as in other brain regions. This may contribute to its overall in vivo effects.
Tanaka
E
E
Vollum Institute, Oregon Health Sciences University, Portland 97201.
North
R A
RA
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D004357:Drug Synergism; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D017397:Prefrontal Cortex / Q000187:drug effects*; D017966:Pyramidal Cells / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D003042:Cocaine; D004298:Dopamine