Helicobacter pylori infection, cigarette smoking and alcohol consumption. A histological and clinical study on 286 subjects.
Helicobacter pylori (Hp) is connected with active/chronic gastritis, gastric gastric and duodenal ulcer. It is not known whether exogenous factors are involved in Hp infection. The aim of this prospective study, performed on 286 consecutive subjects undergoing upper gastrointestinal endoscopy, was to evaluate the influence of smoking and alcohol consumption on Hp infection. For each patient the following parameters were taken into account: sex, age, smoking (no, < 10, > 10 cig/day) and alcohol (no, < 40, > 40 g ethanol/day) intake, antiulcer therapy (no, H2-blockers, omeprazole, sucralfate), presence of gastric or duodenal ulcer (DU). At least two biopsies from both the antrum and the corpus were obtained for histological examination; the gastritis was classified and scored according to the Sydney system.


METHODS
chi-squared test (corrected), Fisher's exact test.


RESULTS
43 pts had Hp (27M, 16F; age 57.8 yrs, range 23-91), 47 Hp ++ (25M, 22F; age 61.1, range 19-86), 81 Hp + (48H, 33F; age 56, range 16-84), 115 Hp- (75M, 40F; age 57.8, range 19-84). Hp infection was found to be significantly correlated with presence of ulcer symptoms, gastritis, lymphoid follicles and, among DU patients, with active DU. The other parameters considered did not influence Hp infection. In conclusion smoking habits and alcohol consumption do not affect Hp infection of the stomach.
Battaglia
G
G
Servizio di Gastroenterologia ed Endoscopia Digestiva, OCR Venezia, Italy.
Di Mario
F
F
Pasini
M
M
Donisi
P M
PM
Dotto
P
P
Benvenuti
M E
ME
Stracca-Pansa
V
V
Pasquino
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology / Q000473:pathology*; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004381:Duodenal Ulcer / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology / Q000473:pathology*; D013276:Stomach Ulcer / Q000453:epidemiology / Q000209:etiology / Q000473:pathology