title: Synthesis and preliminary biological evaluation of analogues of 5,8-dideazaisofolic acid and its 2-desamino-2-methyl derivative containing fluorine at position five.
authors.affiliation: Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425.
authors.forename: J B
authors.initials: JB
authors.lastname: Hynes
authors.forename: O S
authors.initials: OS
authors.lastname: Fetzer
authors.forename: B
authors.initials: B
authors.lastname: Shane
authors.forename: J H
authors.initials: JH
authors.lastname: Freisheim
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005461:Fluorine; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D007939:Leukemia L1210; D008099:Liver / Q000201:enzymology; D008727:Methotrexate / Q000633:toxicity; D051379:Mice; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013552:Swine; D014407:Tumor Cells, Cultured
chemical_list: D005493:Folic Acid Antagonists; D011799:Quinazolines; D005461:Fluorine; C035530:5,8-dideazaisofolic acid; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate