Inositol treatment raises CSF inositol levels.
Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-brain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.
Levine
J
J
Abarbanel Mental Health Center, Bat Yam, Israel.
Rapaport
A
A
Lev
L
L
Bersudsky
Y
Y
Kofman
O
O
Belmaker
R H
RH
Shapiro
J
J
Agam
G
G
D000328:Adult; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007294:Inositol / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D007294:Inositol