title: Clinical trials: two neglected ethical issues.
abstract: Ethical reasons are presented for requiring 1) that a proposal for a clinical trial should be accompanied by a thorough review of all previous trials that have examined the same and closely related questions, and 2) that a trial should be approved by a research ethics committee only if the investigator undertakes to register it in an appropriate register of clinical trials as soon as one exists.
authors.affiliation: UK Cochrane Centre, University of Oxford.
authors.forename: A
authors.initials: A
authors.lastname: Herxheimer
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D026724:Ethical Review; D017041:Ethics Committees; D028744:Ethics Committees, Research; D004992:Ethics, Medical; D033181:Information Dissemination; D011643:Publishing