[Fluctuation of plasma levels of fibrinogen degradation products, fibrin degradation products and total fibrin/fibrinogen degradation products in patients with DIC].
Ten patients with disseminated intravascular coagulation syndrome (DIC) were analyzed using three enzyme linked immunosorbent assays (ORGANON TEKNIKA, Belgium) for fibrin degradation products (FbDP), fibrinogen degradation products (FgDP) and total fibrin/fibrinogen degradation products (TDP). A significant elevation in each parameter and a significant depression of FgDP/FbDP (g/b) ratio were observed in the patients in early stage of DIC, comparing with normal individuals (p < 0.001 and p < 0.01). These results suggested that both fibrinolysis and fibrinogenolysis were marked accelerated, with a superiority in fibrinolysis in those patients. The levels of these parameters decreased and the g/b ratio increased with the passage of the clinical courses in five patients who were improved. Although in five deteriorated cases, the levels were kept high and their g/b ratio showed low continuously. These findings suggested that separated monitoring of fibrinolysis or fibrinogenolysis was useful to study patients with DIC and g/b ratio could be regarded as a helpful indication of therapeutic effects.
Isogai
N
N
Department of Clinical Pathology, Tokyo Medical College.
Kuroso
K
K
Fujimaki
M
M
Yorifuji
H
H
Fukutake
K
K
D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005342:Fibrinolysis; D006801:Humans
D005338:Fibrin Fibrinogen Degradation Products