title: The effect of indomethacin upon cerebral blood flow in healthy volunteers. The influence of moderate hypoxia and hypercapnia.
abstract: In a randomized study of healthy volunteers indomethacin bolus injection followed by continuous infusion decreased CBF from normal levels ranging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/100 g/min. These low levels were sustained during a six hour infusion period. Periods of hypoxia during inhalation of 17% oxygen and hypercapnia during inhalation of 2-4% CO2 normalized CBF.
authors.affiliation: Department of Anesthesiology Hjørring Municipal Hospital, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Jensen
authors.forename: M
authors.initials: M
authors.lastname: Freundlich
authors.forename: L
authors.initials: L
authors.lastname: Bünemann
authors.forename: K
authors.initials: K
authors.lastname: Therkelsen
authors.forename: H
authors.initials: H
authors.lastname: Hansen
authors.forename: G E
authors.initials: GE
authors.lastname: Cold
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D010100:Oxygen / Q000097:blood*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen; D007213:Indomethacin