Vagal nerve and the gastric mucosal defense.
An essential role for an intact vagal nerve has been proven in the development of gastric mucosal cyto- and general protection. On the other hand, chemically-induced (ethanol, HCl, indomethacin) gastric mucosal damage is enhanced after acute surgical vagotomy. The aims of this paper were to study the possible mechanisms of the vagal nerve in the development of gastric mucosal defense. The following questions were addressed: 1) effect of surgical vagotomy on the development of ethanol- (ETOH), HCl-, and indomethacin (IND)-induced gastric mucosal damage: 2) changes in the gastric mucosal defense by scavengers, prostacyclin and other compounds (small doses of atropine and cimetidine; 3) changes in the gastric mucosal vascular permeability due to chemicals; 4) effect of indomethacin in the ETOH and HCl models with and without surgical vagotomy; 5) changes in the gastric mucosal content of prostacyclin and PGE2 in the ETOH and HCl models after surgical vagotomy; and 6) changes in the role of SH-groups in gastric mucosal defense after surgical vagotomy.(ABSTRACT TRUNCATED AT 250 WORDS)
Mózsik
G
G
First Department of Medicine, Medical University of Pécs, Hungary.
Karádi
O
O
Király
A
A
Matus
Z
Z
Sütö
G
G
Tóth
G
G
Vincze
A
A
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D015232:Dinoprostone / Q000378:metabolism; D011464:Epoprostenol / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology; D006851:Hydrochloric Acid / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013272:Stomach Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D000431:Ethanol; D011464:Epoprostenol; D015232:Dinoprostone; D006851:Hydrochloric Acid; D007213:Indomethacin