Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.
A synthetic peptide corresponding to an immunodominant epitope of lymphocytic choriomeningitis virus glycoprotein (LCMV GP) was used to prime or to tolerize CD8+ T cells in vivo, dependent on mode of immunization. Peptide-specific tolerance was then examined in transgenic mice expressing LCMV GP in the beta islet cells of the pancreas; these mice develop CD8+ T-cell-mediated diabetes within 8-14 days after LCMV infection. Specific peptide-induced tolerance prevented autoimmune destruction of beta islet cells and diabetes in this transgenic mouse model.
Aichele
P
P
Department of Pathology, University of Zürich, Switzerland.
Kyburz
D
D
Ohashi
P S
PS
Odermatt
B
B
Zinkernagel
R M
RM
Hengartner
H
H
Pircher
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D007108:Immune Tolerance; D007114:Immunization; D016056:Immunodominant Epitopes / Q000008:administration & dosage / Q000235:genetics; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology; D008216:Lymphocytic Choriomeningitis / Q000517:prevention & control; D008217:Lymphocytic choriomeningitis virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
D016056:Immunodominant Epitopes; D009842:Oligopeptides; D014764:Viral Proteins