[Genetic dimorphism in beta-aminoisobutyric acid excretion in patients with atherosclerosis of the coronary artery and in groups at risk for atherosclerosis in the Lithuanian population].
Frequency of genetic variants of excretion of beta-aminoisobutyric acid (BAIB) in the urea was examined in patients suffering from atherosclerosis of coronary arteries and in risk group for atherosclerosis: children frequently suffering from respiratory viral infection, children with insulin-dependent diabetes mellitus (IDDM) and in adults suffering from IDDM and non-insulin-dependent diabetes mellitus. With the aim to determine whether excretion of BAIB could be related with CMV persistence of with proteolytic activity of blood serum the IgG class antibodies against CMV and level of alpha 1-proteinase inhibitor (alpha 1-PI) in blood serum was tested also. Frequency of high excretors of BAIB was found significantly more often (P < 0.01) in children suffering from virus infection compared to that of population. Frequency distribution of BAIB excretion showed that "high excretors" were found significantly more often in children suffering from atherosclerosis. The difference of BAIB excretion among healthy and diabetics was not defined (P > 0.05). The changes of excretion of BAIB in urea were not related with quantity of alpha 1-PI in blood serum. Investigation reveal a possible relation between high BAIB excretor and latent CMV infection and that this may impact atherogenesis. This leads to a suggestion that children who are often ill with respiratory virus infection may constitute a risk group for coronary atherosclerosis.
Spitsyn
V A
VA
Stakishaĭtis
D V
DV
Preĭksha
R A
RA
D000293:Adolescent; D000328:Adult; D000621:Aminoisobutyric Acids / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000235:genetics* / Q000652:urine; D003586:Cytomegalovirus Infections / Q000150:complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D006801:Humans; D008097:Lithuania; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012141:Respiratory Tract Infections / Q000150:complications / Q000382:microbiology; D012307:Risk Factors; D014777:Virus Diseases / Q000150:complications
D000621:Aminoisobutyric Acids; C033435:3-aminoisobutyric acid
Issledovanie geneticheskogo dimorfizma v ékskretsii beta-aminoizomaslianoĭ kisloty u bol'nykh aterosklerozom koronarnykh arteriĭ i v gruppakh ateroskleroznogo riska v litovskoĭ populiatsii.