[Studies on the effect of cephradine, cefuroxime, lincomycin and amikacin on complement levels in experimental animals].
Rabbits were injected intramuscularily with antibiotics in mean therapeutic doses (calculated by body weight) for the period of 7 days. Group I received cephradine, group II--cefuroxime, group III--lincomycin and group IV--amikacin. Determination of complement level by CH50 method was performed before application of antibiotics and at 7, 14, 28 and 42 day of the study. Application of the cephalosporin antibiotics did not result in any changes in the complement level. After application of lincomycin, complement level increased at the 17 day and after amikacin treatment it was higher after 7 days of investigation.
Jasińska
B
B
Katedra i Zakład Mikrobiologii Lekarskiej AM w Lublinie.
Szeniawska
A
A
Hencner
Z
Z
Fota-Markowska
H
H
D000583:Amikacin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology; D002515:Cephradine / Q000494:pharmacology; D003165:Complement System Proteins / Q000187:drug effects* / Q000378:metabolism; D008034:Lincomycin / Q000494:pharmacology; D011817:Rabbits
D000900:Anti-Bacterial Agents; D000583:Amikacin; D003165:Complement System Proteins; D008034:Lincomycin; D002515:Cephradine; D002444:Cefuroxime
Badania nad wpływem cefradyny, cefuroksymu, linkomycyny i amikacyny na poziom dopełniacza u zwierzat doświadczalnych.