Mechanism of thymidylate synthase inhibition by N4-hydroxy-(N4-hydroxy-5- fluoro)-dCMP in view of the structure and conformation of N4-hydroxy-(N4-hydroxy-5-fluoro)-cytosine calculated by the AB initio quantum mechanical methods.
Leś
A
A
Department of Chemistry, University of Warsaw, Poland.
Adamowicz
L
L
Rode
W
W
D002151:Calorimetry; D003843:Deoxycytidine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005437:Flucytosine / Q000031:analogs & derivatives* / Q000737:chemistry; D007536:Isomerism; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011789:Quantum Theory; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
D003843:Deoxycytidine Monophosphate; C067000:N(4)-hydroxy-5-fluorodeoxycytidine monophosphate; C081056:N(4)-hydroxy-5-fluorocytosine; D005437:Flucytosine; D013940:Thymidylate Synthase