Prostacyclins in diabetes: an electrophysiological study.
Twelve patients with juvenile (insulin-dependent, type I) diabetes were treated either with prostacyclins or placebo in a double-masked randomized study. The electroretinogram (ERG) was recorded before, 1 day and 8 months after treatment. An analysis of variance and covariance was carried out to evaluate possible treatment or time effects on the a and b waves and the oscillatory potentials of the ERG. Mean values of potentials displayed a decrease of amplitude and an increase of latency over the follow-up period in all patients. No statistically significant difference between treated and placebo groups could be proven.
Lessel
M R
MR
Department of Ophthalmology, University of Vienna, Austria.
Thaler
A
A
Scheiber
V
V
Heilig
P
P
Gottlob
I
I
Schernthaner
G
G
D000328:Adult; D000704:Analysis of Variance; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000188:drug therapy / Q000503:physiopathology*; D004311:Double-Blind Method; D004596:Electroretinography / Q000187:drug effects*; D011464:Epoprostenol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009991:Oscillometry; D011446:Prospective Studies
D011464:Epoprostenol