Vitamin K-antagonistic effect of plastoquinone and ubiquinone derivatives in vitro.
Decyl-ubiquinone and decyl-plastoquinone were used as model compounds to test the potential effect of quinone derivatives on two enzymes of the vitamin K cycle in vitro. Substantial inhibition of gamma-glutamate carboxylase was found, whereas vitamin K-epoxide reductase was inhibited to a much lesser extent. The inhibitory effect of both decylquinones was eliminated in a time-dependent way by solubilized microsomes, but not by purified carboxylase. Since a wide variety of prenylquinones occur as micronutrients, these results are of potential relevance for the effects of natural quinones in the human diet.
Saupe
J
J
IIIrd Department of Internal Medicine, Moabit Hospital, Berlin, Germany.
Ronden
J E
JE
Soute
B A
BA
Vermeer
C
C
D000818:Animals; D019735:Carbon-Carbon Ligases; D002417:Cattle; D007700:Kinetics; D008025:Ligases / Q000037:antagonists & inhibitors; D008099:Liver / Q000201:enzymology; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014812:Vitamin K / Q000037:antagonists & inhibitors*; D064417:Vitamin K Epoxide Reductases
C085776:decylplastoquinone; D014812:Vitamin K; D014451:Ubiquinone; C060262:2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone; D006899:Mixed Function Oxygenases; D064417:Vitamin K Epoxide Reductases; D008025:Ligases; D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase; D010971:Plastoquinone