[Radioprotective effect of synthetic immunomodulators on hemopoietic CFU-S].
The radiotherapeutic effect of thymogen (Glu-Trp) and thymohexin (Arg-Lys-Asp-Val-Tyr-Arg) synthetic peptide immunomodulators was investigated. Both thymogen and thymohexin were demonstrated to be able to reduce the damaging effect of ionizing radiation (1 Gy) on CFU-S by half. The treatment by these preparations after irradiation at dose of 4 Gy leads to more intensive restoration of CFU-S population as compared with control.
Sëmina
O V
OV
Semenets
T N
TN
Deĭgin
V I
VI
Korotkov
A M
AM
Poverennyĭ
A M
AM
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000595:Amino Acid Sequence; D000818:Animals; D004151:Dipeptides; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology / Q000627:therapeutic use*; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D009842:Oligopeptides; D010455:Peptides; D011837:Radiation-Protective Agents; C080035:thymohexin; C060736:thymogen
Radiozashchitnoe deĭstvie sinteticheskikh immunomoduliatorov na krovetvorenie KOEc.