title: [The multinucleate cells of the spermatogenic layer in rats as a criterion of hypoxic damage to the testis].
abstract: The formation and dynamics of transformations of multinucleated cells in the spermatogenic layer was studied in mature male albino rats in a model experiment with 10-12 min. long clinical death followed by revivification at different periods of the postreanimation period. The maximum formation of multinucleated cells is observed on the 2nd-3rd days after revivification, and further their occurrence becomes less. With an increase of degenerative alterations in the nuclei and cytoplasm of multinucleated cells, the latter become isolated from the spermatogenic layer causing disturbances of its structure. A variant with the multiple formation of multinucleated cells is described resulting in an injury of the spermatogenic layer at a considerable distance. A supposition is put forward of the relationship of the formation of multinucleated cells with the clonal syncytial principle of organization of the developing sex cells and the cycle of spermatogenesis. The appearance of multinucleated cells is an undoubtable indicator of degenerative alterations of the spermatogenic layer under conditions of hypoxia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Apsaliamov
authors.forename: A N
authors.initials: AN
authors.lastname: Bazhanov
authors.forename: V A
authors.initials: VA
authors.lastname: Savenko
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure*; D000860:Hypoxia / Q000473:pathology*; D008297:Male; D051381:Rats; D012151:Resuscitation; D013091:Spermatogenesis; D013094:Spermatozoa / Q000648:ultrastructure*; D013733:Testicular Diseases / Q000473:pathology*; D013737:Testis / Q000648:ultrastructure*; D013997:Time Factors
vernacular_title: Mnogoiadernye kletki spermatogennogo plasta u krys kak kriteriĭ gipoksicheskogo povrezhdeniia semennika.