Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy.
Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56,PGK1).
Fain
P R
PR
Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City 84108.
Barker
D F
DF
Chance
P F
PF
D000328:Adult; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D014960:X Chromosome
D005819:Genetic Markers