[Experimental study on the etiology of ischemic colitis].
A reliable experimental model for ischemic colitis in rat could be obtained by ligating the marginal vessels of the colon 3 days after attaching the ring to induce partial colon obstruction. This model has the advantage of enabling to observe the chronic progress and the organ of the sideration to clarify the cause of ischemic colitis. The decrease of blood flow within the colonic mucosa continued up to 7 days after ligation in rat with partial obstruction, while no apparent abnormal changes were observed, and the previous level for several hours in the rats with out attaching the ring. This fact proved that the RT group is in a state easily developing sideration due to the sustained partial colon obstruction. The reactant reacting with thiobarbituric acid (TBA) was found to increase, in particular, 6 or more hours after ligation of vessels. A superoxide scavenger, liposomal-encapsulated superoxide dismutase (1-SOD) suppressed development of the ischemic lesion. The change in free radicals is therefore, considered to be involved in the occurrence of ischemic colitis.
Ichihara
T
T
First Department of Surgery, Kobe University School of Medicine, Japan.
Nagahata
Y
Y
Urakawa
T
T
Saitoh
Y
Y
D000818:Animals; D017091:Colitis, Ischemic / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D003106:Colon / Q000098:blood supply; D004195:Disease Models, Animal; D005609:Free Radicals; D007413:Intestinal Mucosa / Q000098:blood supply; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow
D005609:Free Radicals; D010100:Oxygen