Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study.
A retrospective study of bone mineral density (BMD) changes was performed in 53 osteoporotic women prior to carrying out a prospective study. Comparisons between BMD of controls (n = 16) and treated groups over a 14-22 month period showed that fluoride (n = 10) induced a significant (P < 0.05) increase in vertebral and a slight decrease in femoral BMD, whereas silicon (n = 8) induced a significant (P < 0.05) increase in femoral BMD. Etidronate (n = 13) and, to a lesser extent, magnesium (n = 6), induced a slight although statistically non-significant increase in vertebral BMD.
Eisinger
J
J
Centre Hospitalier de Toulon, France.
Clairet
D
D
D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D012968:Etidronic Acid / Q000494:pharmacology*; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D008274:Magnesium / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000503:physiopathology*; D012189:Retrospective Studies; D012825:Silicon / Q000494:pharmacology*
D008274:Magnesium; D012968:Etidronic Acid; D005459:Fluorides; D012825:Silicon