Delayed hypersensitivity, immune deviation, antigen processing and T-cell subset selection in syphilis pathogenesis and vaccine design.
T-cell mediated delayed-type hypersensitivity (DTH) is the predominant immune mechanism for clearing tissues of infecting organisms in the primary lesion of syphilis. Here, Stewart Sell and Pei-Ling Hsu propose a strategy for vaccination against syphilis in which selective induction of DTH may be accomplished by using BCG vectored vaccines containing selected DNA sequences for T. pallidum antigens.
Sell
S
S
Dept of Pathology, University of Texas Health Science Center, Houston 77030.
Hsu
P L
PL
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D001428:Bacterial Vaccines; D001483:Base Sequence; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008969:Molecular Sequence Data; D009163:Mycobacterium bovis / Q000235:genetics; D013587:Syphilis / Q000276:immunology* / Q000517:prevention & control; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014210:Treponema pallidum / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D014614:Vaccines, Synthetic