title: [Positive effect of intermittent overpressure and underpressure (Vacusac) in intermittent claudication].
abstract: Twenty-two patients with intermittent claudication were included in a double-blinded, randomized trial comparing the effects of 25 treatments with intermittent suction and pressure (Vacusac treatment) to 25 placebo applications given over a period of two months. Twelve patients participated in an open trial investigating the effects of the same treatment on adenosine diphosphate (ADP)-induced platelet aggregation and fibrinolysis. Active treatment resulted in significant improvements in pain-free and maximal walking distances, whereas no changes could be found during placebo application. Active treatment caused significant increments in ADP-induced platelet aggregation, while the effects on fibrinolysis were uncertain. It is concluded that intermittent suction and pressure treatment offers a new approach for conservative treatment of intermittent claudication.
authors.affiliation: Frederiksberg Hospital, klinisk fysiologisk nuklearmedicinsk afdeling.
authors.forename: J
authors.initials: J
authors.lastname: Mehlsen
authors.forename: H
authors.initials: H
authors.lastname: Himmelstrup
authors.forename: B
authors.initials: B
authors.lastname: Himmelstrup
authors.forename: K F
authors.initials: KF
authors.lastname: Winther Hansen
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011312:Pressure; D013396:Suction; D016138:Walking
vernacular_title: Positiv effekt af intermitterende over- og undertryk (Vacusac) ved claudicatio intermittens.