[Level of fructose-2,6-bisphosphate and activity of fructose-1,6-bisphosphatase in hepatocyte suspensions in streptozotocin diabetes].
Content of fructose-2,6-bisphosphate was drastically decreased (about 5-fold) in hepatocyte suspension obtained from rats with streptozotocin-induced diabetes, as compared with that of control animals. At the same time, activity of fructose-1,6-bisphosphatase was increased 2-fold in these hepatocytes. Incubation mixture of the hepatocytes from the diabetes impaired animals contained only low amounts of lactate.
Golubev
M A
MA
Markova
M S
MS
Stvolinskaia
N S
NS
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism*; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005635:Fructosediphosphates / Q000378:metabolism*; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D005635:Fructosediphosphates; D007773:Lactates; D019344:Lactic Acid; D013311:Streptozocin; C027652:fructose 2,6-diphosphate; D006597:Fructose-Bisphosphatase
Soderzhanie fruktozo-2,6-bisfosfata i aktivnost' fruktozo-1,6-bisfosfatazy v suspenzii gepatotsitov pri streptozototsinovom diabete.