Relation of IL-2, IL-3 and IL-4 with allergic asthma induced by spores of mushroom (Pleurotus sapidus).
The effects of IL-2, IL-3, and IL-4 activities on occurrence of allergic asthma induced by spores of mushroom have been studied by measuring the IL-2, IL-3, and IL-4 activities in culture supernatants of spleen lymphocytes from guinea pigs being stimulated with Con A. The IL-4 activity (14.9 +/- 0.18 u) in the culture supernatant was higher than control group (6.7 +/- 1.5 u). The IL-2 and IL-3 activities were all similar to that of the control group. The IL-4 synthesis was similarly raised as the IL-4 activity. These results indicated that there is a relationship between the occurrence of allergic asthma and the increase of IL-4.
Lang
W F
WF
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
Li
D D
DD
Zhou
J H
JH
Chen
W
W
Li
F
F
D000818:Animals; D001249:Asthma / Q000209:etiology / Q000378:metabolism*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000209:etiology / Q000378:metabolism*; D007376:Interleukin-2 / Q000096:biosynthesis / Q000378:metabolism*; D007377:Interleukin-3 / Q000096:biosynthesis / Q000378:metabolism*; D015847:Interleukin-4 / Q000096:biosynthesis / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D011124:Polyporaceae; D012016:Reference Values; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013172:Spores, Fungal; D014407:Tumor Cells, Cultured
D007376:Interleukin-2; D007377:Interleukin-3; D003208:Concanavalin A; D015847:Interleukin-4