title: Improved cardiac performance and reduced pulmonary vascular constriction by epinephrine administration via a left atrial catheter in cardiac surgical patients.
abstract: Diminished left ventricular contractility and increased right ventricular afterload are issues in cardiac surgery. The usual administration of catecholamines (epinephrine) via the central venous (CV) catheter increases cardiac output, but also may increase pulmonary vascular constriction. Epinephrine was, therefore, administered via the left atrial (LA) catheter or the CV catheter in 8 cardiac surgery patients, each serving as his or her own control. The LA administration of epinephrine has an advantage with its immediate effect on the coronary circulation, while avoiding associated pulmonary vasoconstriction by passing through the systemic capillary bed before reaching the lung. It was found in this study that administration of epinephrine via an LA catheter increased the average cardiac output by 1.05 L/min, which was significantly (P < 0.05) greater than with administration via the CV catheter. With LA administration of epinephrine, systemic arterial pressure (systolic arterial pressure and diastolic arterial pressure) (SAP, DAP) were also elevated to a greater extent than by CV administration. On the other hand, pulmonary arterial pressures (systolic pulmonary arterial pressure and diastolic pulmonary arterial pressure) (SPAP, DPAP) were less elevated than by administration via the CV catheter. This produced increased coronary perfusion and a smaller increase in pulmonary vascular tone by LA administration in contrast to CV administration of epinephrine. It is concluded that epinephrine administration via an LA catheter improved myocardial performance and pulmonary perfusion due to direct entry of the agent into the coronary circulation and partial metabolism while passing through the systemic capillary bed before reaching the lung.
authors.affiliation: Department of Cardiothoracic Anesthesia and Intensive Care, Clinic of Anesthesia, University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Haider
authors.forename: W
authors.initials: W
authors.lastname: Zwölfer
authors.forename: M
authors.initials: M
authors.lastname: Hiesmayr
authors.forename: P
authors.initials: P
authors.lastname: Mares
authors.forename: P
authors.initials: P
authors.lastname: Keznickl
authors.forename: D
authors.initials: D
authors.lastname: Heilinger
authors.forename: F
authors.initials: F
authors.lastname: Coraim
authors.forename: A
authors.initials: A
authors.lastname: Gabriel
authors.forename: G
authors.initials: G
authors.lastname: Grubhofer
authors.forename: F
authors.initials: F
authors.lastname: Hrska
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D006328:Cardiac Catheterization / Q000379:methods*; D002302:Cardiac Output / Q000187:drug effects*; D002303:Cardiac Output, Low / Q000517:prevention & control; D006348:Cardiac Surgical Procedures; D002405:Catheterization, Central Venous; D002496:Central Venous Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004837:Epinephrine / Q000008:administration & dosage* / Q000627:therapeutic use; D006325:Heart Atria; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*; D016277:Ventricular Function, Left / Q000187:drug effects; D017725:Ventricular Pressure / Q000187:drug effects
chemical_list: D004837:Epinephrine