The alkane-inducible Candida maltosa ALI1 gene product is an NADH:ubiquinone oxidoreductase subunit homologue.
The ALI1 gene product in Candida maltosa was previously shown to be essential for n-alkane assimilation, possibly as a transcription factor [Hwang et al., Gene 106 (1991) 61-69]. We show that the predicted sequence is highly homologous to a subunit of respiratory complex I from another fungus, Neurospora crassa, and from Bos taurus. The predicted protein contains a motif conserved in this subunit from mitochondria, chloroplasts and bacteria. It also contains an N-terminal sequence that suggests a mitochondrial (mt) localization and a role for mt respiration in n-alkane assimilation.
Souza
A E
AE
Institute of Genetics, University of Glasgow, Scotland, UK.
Myler
P J
PJ
Stuart
K D
KD
D000473:Alkanes / Q000378:metabolism; D000595:Amino Acid Sequence; D002175:Candida / Q000201:enzymology / Q000235:genetics*; D004790:Enzyme Induction; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D000473:Alkanes; D016660:NAD(P)H Dehydrogenase (Quinone)