title: Endocarditis due to Staphylococcus lugdunensis: report of 11 cases and review.
abstract: Staphylococcus lugdunensis is a recently described coagulase-negative staphylococcus that has been associated with human infections, including nine reported cases of infective endocarditis. The present study describes 11 other cases of infective endocarditis caused by this organism. The infection occurred in patients whose mean age was 61 years and was community-acquired in most cases. A preexisting cardiac abnormality was present in eight patients. Three of the 11 infections involved prosthetic valves. Ten strains were susceptible to penicillin. The destructive course of the infection, the need for valve replacement, and the high mortality suggest that S. lugdunensis causes a virulent form of endocarditis.
authors.affiliation: Laboratoire de Bactériologie, Hôpital Louis Pradel, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Vandenesch
authors.forename: J
authors.initials: J
authors.lastname: Etienne
authors.forename: M E
authors.initials: ME
authors.lastname: Reverdy
authors.forename: S J
authors.initials: SJ
authors.lastname: Eykyn
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D013210:Staphylococcus / Q000472:pathogenicity; D014774:Virulence; D014946:Wound Infection / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents