[Monoclonal antibodies against D-antigen of the rhesus system].
The authors review current data on the production and characterization of anti-D monoclonal antibodies. The main methods for establishment of anti-D antibody secreting cell lines are considered: EBV-transformation of B lymphocytes from immune donor and hybridization with malignant human or murine cell lines. Serologic and immunological properties of anti-D monoclonal reagents for blood group Rh-typing as well as feasibility of using anti-D monoclonal antibodies as a modality against hemolytic disease of the newborn are discussed.
Olovnikova
N I
NI
Deriugina
E I
EI
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D002460:Cell Line; D006801:Humans; D051379:Mice; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D000911:Antibodies, Monoclonal; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen
Monoklonal'nye antitela k D-antigenu sistemy rezus.