Acute effects of m-xylene inhalation on body sway, reaction times, and sleep in man.
Nine male volunteers were exposed to either a constant or a fluctuating exposure pattern of m-xylene with a time-weighted average exposure concentration of 200 ppm in both cases. The subjects remained sedentary throughout the exposure, or the exercised at 100 W for 10 min at the beginning of the morning and the afternoon sessions. In another experiment, 12 sedentary male volunteers were exposed to a fixed 200 ppm of m-xylene. The effects of m-xylene on body sway, reaction time performance, and overnight sleep were measured. Body balance was stabilized after exposure to the peaks of 400 ppm of m-xylene in both sedentary and exercising subjects. Simple visual reaction times were prolonged after the peak exposures at rest whereas auditive choice reaction times were prolonged after peaks combined with exercise. Exposure to m-xylene at a constant level of 200 ppm did not affect the ratio of "active" to "quiet" sleep in the volunteers as measured with the static charge sensitive bed recording, but decreased slightly the number of body movements in bed. On the next morning no changes were found in body sway and reaction time performance as compared to the morning before exposure.
Laine
A
A
Social Insurance Institution, Helsinki, Finland.
Savolainen
K
K
Riihimäki
V
V
Matikainen
E
E
Salmi
T
T
Juntunen
J
J
D000328:Adult; D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D017286:Polysomnography / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects; D016037:Single-Blind Method; D012894:Sleep Stages / Q000187:drug effects*; D014992:Xylenes / Q000493:pharmacokinetics / Q000633:toxicity*
D000395:Air Pollutants, Occupational; D014992:Xylenes; C031285:3-xylene