title: Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: M
authors.initials: M
authors.lastname: Pavlovic
authors.forename: J J
authors.initials: JJ
authors.lastname: Leffert
authors.forename: O
authors.initials: O
authors.lastname: Russello
authors.forename: M A
authors.initials: MA
authors.lastname: Bunni
authors.forename: G P
authors.initials: GP
authors.lastname: Beardsley
authors.forename: D G
authors.initials: DG
authors.lastname: Priest
authors.forename: G
authors.initials: G
authors.lastname: Pizzorno
mesh_terms: D001665:Binding Sites; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D002460:Cell Line; D004351:Drug Resistance; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000378:metabolism*; D005493:Folic Acid Antagonists / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008727:Methotrexate / Q000378:metabolism; D010453:Peptide Synthases / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013763:Tetrahydrofolates / Q000378:metabolism / Q000633:toxicity*; D014407:Tumor Cells, Cultured
chemical_list: D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists; D011956:Receptors, Cell Surface; D013763:Tetrahydrofolates; C045894:lometrexol; D005492:Folic Acid; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate