Antibacterial activity of teprenone, a non water-soluble antiulcer agent, against Helicobacter pylori.
Teprenone, a non water-soluble antiulcer agent, is a derivative of terpene. The antibacterial activity of teprenone against Helicobacter pylori was examined by the disc method and survival test in albumin broth including teprenone. Growth of H. pylori around the disc charged with teprenone was inhibited on Brucella agar supplemented with bovine serum albumin fraction V, charcoal, or beta-cylodextrin, but not with blood or egg yolk emulsion. Furthermore, when H. pylori was exposed in broth including teprenone, H. pylori did not survive after 20 hours at 0.25 approximately 10 ppm. These results indicate that teprenone has antibacterial activity against H. pylori.
Ishii
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Department of Bacteriology, Osaka City Institute of Public Health and Environmental Sciences, Japan.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D012995:Solubility
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D004224:Diterpenes; C031049:geranylgeranylacetone