title: Analysis of dystrophin gene deletions in patients from the Mexican population with Duchenne/Becker muscular dystrophy.
abstract: Forty unrelated Mexican patients with Duchenne/Becker muscular dystrophy were analyzed for intragenic DMD gene deletions, using the multiplex amplification of 15 deletion-prone exons described by Chamberlain et al. and Beggs et al. The percentage of deletions was 52.5%, and the majority of them (86.3%) were located at the hot spot deletion region which encompasses exons 44-55. This frequency is higher than that found in American and European populations. There were no correlations between deletion size, location and clinical severity.
authors.affiliation: Departamento de Genética y Biología Molecular, CINVESTAV-IPN, Escuela Nacional de Estudios Profesionales Iztacala-UNAM, México, D.F.
authors.forename: R
authors.initials: R
authors.lastname: Coral-Vázquez
authors.forename: D
authors.initials: D
authors.lastname: Arenas
authors.forename: B
authors.initials: B
authors.lastname: Cisneros
authors.forename: L
authors.initials: L
authors.lastname: Peñaloza
authors.forename: S
authors.initials: S
authors.lastname: Kofman
authors.forename: F
authors.initials: F
authors.lastname: Salamanca
authors.forename: C
authors.initials: C
authors.lastname: Montañez
mesh_terms: D016189:Dystrophin / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005091:Exons; D017353:Gene Deletion; D005796:Genes; D006801:Humans; D008297:Male; D008800:Mexico; D009136:Muscular Dystrophies / Q000208:ethnology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012720:Severity of Illness Index
chemical_list: D016189:Dystrophin