In vivo interaction of neuropeptide Y and peptide YY with sigma receptor sites in the mouse brain.
Neuropeptide Y (NPY-(1-36)), peptide YY (PYY) and various other peptides were investigated for their interaction with the binding of [3H](+)-SKF10,047 to sigma binding sites in mouse hippocampus in vivo. NPY-(1-36), PYY-(1-36), [Leu31,Pro34]NPY, NPY-(2-36), and NPY-(3-36) inhibited the labelling of a population of haloperidol-sensitive binding sites corresponding to 35% of the specific binding. These in vivo binding results confirm the previous interaction already reported between NPY peptides and sigma binding sites.
Roman
F J
FJ
Institut de Recherche Jouveinal, Fresnes, France.
Martin
B
B
Junien
J L
JL
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D051379:Mice; D009478:Neuropeptide Y / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D019894:Peptide YY; D010455:Peptides / Q000378:metabolism*; D011869:Radioligand Assay; D017480:Receptors, sigma / Q000378:metabolism*
D009478:Neuropeptide Y; D009479:Neuropeptides; D010455:Peptides; D017480:Receptors, sigma; D019894:Peptide YY