title: Rat selection test with respect to laxative activity induced by barbaloin.
abstract: As individual differences in sensitivity in the laxative activity of barbaloin were observed in rats, a selection test for barbaloin (31.1 mg/kg, p.o.) was carried out between 1989 and 1991. The annual percentages of rats exhibiting a reaction positive to barbaloin were almost constant (about 57%). We propose that rats positive to barbaloin should be selected for studies on the laxative effect of barbaloin.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Tanizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takino
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D002400:Cathartics / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results
chemical_list: D000873:Anthracenes; D002400:Cathartics; C045601:barbaloin