Modulation of hepatic glutathione system of enzymes in suckling mouse pups exposed translactationally to malathion.
The present study examines the transmammary modulation of the glutathione system of enzymes in the F1 generation of mouse pups postnatally exposed to malathion. Lactating Swiss albino mice received either 30 or 100 mg malathion kg-1 body wt. (98% pure) for 14 or 21 days postpartum. The acid-soluble sulphydryl content was significantly increased (P < 0.001) in the liver of 14-day-old pups of dams that had received the higher malathion dose. A similar significant increase was seen in the 21-day-old male pups of dams that had received 30 mg (P < 0.05) or 100 mg (P < 0.01) malathion kg-1 body wt. Dams showed an enhanced hepatic glutathione S-transferase activity following treatment with 100 mg malathion kg-1 body wt. for 14 days (P < 0.02) and 21 days (P < 0.001). Pups of either age groups also showed enhanced hepatic glutathione S-transferase activity (P < 0.001). A significant enhancement in glutathione reductase activity was observed with malathion treatment in livers of dams and pups (P < 0.001). However, dams that had received 30 mg malathion kg-1 body wt. daily for 21 days or 100 mg malathion kg-1 body wt. for either 14 or 21 days showed significantly reduced hepatic glutathione peroxidase activity (P < 0.01, P < 0.001). A significant decrease in glutathione peroxidase activity was also observed in the liver of the 21-day-old male (P < 0.01) and female (P < 0.02) pups of dams that were treated with the higher dose of malathion.
Chhabra
S K
SK
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Hashim
S
S
Rao
A R
AR
D000818:Animals; D000833:Animals, Suckling; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000187:drug effects; D005980:Glutathione Reductase / Q000187:drug effects; D005982:Glutathione Transferase / Q000187:drug effects; D007774:Lactation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008294:Malathion / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013438:Sulfhydryl Compounds / Q000378:metabolism
D013438:Sulfhydryl Compounds; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D008294:Malathion