Endogenous nitric oxide counteracts antigen-induced bronchoconstriction.
In anesthetized, artificially ventilated guinea pigs immunized against ovalbumin, challenge with aerosolized ovalbumin (0.1 mg) elicited a substantial and sustained increase of insufflation pressure. The inhibitor of endogenous nitric oxide (NO) synthesis, L-NAME (N omega-nitro-L-arginine methylester, 30 mg kg-1 i.v.), markedly augmented the response, the potentiation of which could be prevented by NO (20 p.p.m.) in the inhaled air. The results indicate an inhibitory effect of endogenous NO on antigen-induced bronchoconstriction.
Persson
M G
MG
Department of Physiology, Karolinska Institute, Stockholm, Sweden.
Friberg
S G
SG
Hedqvist
P
P
Gustafsson
L E
LE
D000336:Aerosols; D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D016084:Bronchoconstriction / Q000187:drug effects; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D007114:Immunization; D007275:Injections, Intravenous; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000502:physiology*; D010047:Ovalbumin / Q000276:immunology
D000336:Aerosols; D009569:Nitric Oxide; D010047:Ovalbumin; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester