Eicosanoids and ovulation.
PGs and probably other eicosanoids play a fundamental role in the process of ovulation, more specifically in the mechanism of follicle wall rupture. Although the nature of this role has yet to be established a number of plausible theories exist. It seems likely that altered PG metabolism is responsible for some cases of human female subfertility. The potential for fertility control by PG inhibition is an exciting possibility for the future.
Priddy
A R
AR
Department of Obstetrics and Gynaecology, University Hospital of South Manchester, UK.
Killick
S R
SR
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D015777:Eicosanoids / Q000037:antagonists & inhibitors / Q000502:physiology*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology; D008322:Mammals / Q000502:physiology; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D006080:Ovarian Follicle / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects / Q000502:physiology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017382:Reactive Oxygen Species
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015777:Eicosanoids; D006065:Gonadotropins, Pituitary; D011448:Prostaglandin Antagonists; D017382:Reactive Oxygen Species; D007213:Indomethacin