Distribution and dosimetry of 111In DTPA-D-Phe-octreotide in man assessed by whole body scintigraphy.
The distribution and dosimetry of the somatostatin analog 111In-DTPA-octreotide was evaluated in 6 patients. Whole body scintigraphy in anterior and posterior projections was performed 0.5, 5, 24 and 48 hours after injection. Region-of-interest analysis for different organs and the whole body was used to determine 111In octreotide half-life-corrected uptake in absolute and relative terms. A rapid initial uptake was seen in the kidneys (2-7%), the spleen (2-6%) and in the liver (4-8%). A lower uptake was seen in the pituitary gland (maximum 0.3%), the thyroid (maximum 0.07%), in the female breast (maximum 1.2%), in the urinary bladder and in the intestinal tract. The elimination pattern varied between different organs. The effective dose equivalent was evaluated to be in the range 0.08 to 0.13 mSv/MBq (average 0.10 mSv/MBq). The behavior of 111In-DTPA-octreotide suggests follow-up scintigraphy in a period extending up to at least 24 hours after injection.
Bajc
M
M
Department of Clinical Physiology, University Hospital, Lund, Sweden.
Palmer
J
J
Ohlsson
T
T
Edenbrandt
L
L
D000042:Absorption; D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007205:Indium Radioisotopes; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000493:pharmacokinetics*; D004369:Pentetic Acid; D010902:Pituitary Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D011829:Radiation Dosage; D017481:Receptors, Somatostatin / Q000378:metabolism*; D013154:Spleen / Q000000981:diagnostic imaging / Q000378:metabolism; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D004369:Pentetic Acid; D015282:Octreotide