Discrimination between different types of white matter edema with diffusion-weighted MR imaging.
Brain edema can be classified into three categories: vasogenic, cytotoxic, and interstitial. The mechanism of edema is thought to be different in each type. The authors studied the movement of water molecules in each type of white matter edema in a rat model by using diffusion-weighted magnetic resonance imaging. Conventional T2-weighted imaging did not allow distinction between the three types of white matter edema; the three types of edema were, however, distinguished by using diffusion-weighted imaging. The apparent diffusion coefficient (ADC) of water was different in each type of edema. Water molecules in cytotoxic edema induced by triethyl-tin intoxication showed a smaller and less anisotropic ADC than in normal white matter. In contrast, water in vasogenic edema induced by cold injury had a larger and more anisotropic ADC than in normal white matter. Water in interstitial edema due to kaolin-induced hydrocephalus had an anisotropic and very large ADC.
Ebisu
T
T
Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japan.
Naruse
S
S
Horikawa
Y
Y
Ueda
S
S
Tanaka
C
C
Uto
M
M
Umeda
M
M
Higuchi
T
T
D000818:Animals; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003080:Cold Temperature; D003937:Diagnosis, Differential; D004058:Diffusion; D006849:Hydrocephalus / Q000150:complications; D007616:Kaolin; D008279:Magnetic Resonance Imaging; D008297:Male; D008961:Models, Structural; D051381:Rats; D017208:Rats, Wistar; D014267:Triethyltin Compounds / Q000633:toxicity
D014267:Triethyltin Compounds; D007616:Kaolin