Inhibition of NF-kappa B DNA binding activity by alpha-tocopheryl succinate.
Vitamin E derivatives have been shown to inhibit tumor necrosis factor-induced NF-kappa B activation in human Jurkat T cells. The present report demonstrates that alpha-tocopheryl succinate directly blocks DNA binding activity of activated NF-kappa B, as well as the NF-kappa B activation induced by okadaic acid, an inhibitor of protein phosphatases 1 and 2A. In contrast, alpha-tocopherol, alpha-tocopheryl acetate and 2,2,5,7,8-pentamethyl-6-hydroxychromane have no effects. These observations suggest that the mechanism of alpha-tocopheryl succinate action against NF-kappa B is different from those of other vitamin E derivatives.
Suzuki
Y J
YJ
Department of Molecular & Cell Biology, University of California, Berkeley 94720.
Packer
L
L
D001483:Base Sequence; D004247:DNA / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D024505:Tocopherols; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D016328:NF-kappa B; D014810:Vitamin E; D004247:DNA; D024502:alpha-Tocopherol; D024505:Tocopherols