title: [Chemotherapy of destructive pulmonary tuberculosis with antioxidants and antihypoxic agents].
abstract: The trial included 155 patients with destructive pulmonary tuberculosis: 60 on conventional antibacterial therapy (isoniazid, rifampicin, streptomycin), 95 on intensive chemotherapy (isoniazid, rifampicin, streptomycin, pirazinamid or ethambutol, vitamins for initial 2-3 months). 69 patients from the latter group received adjuvant antioxidants (tocopherol acetate or galascorbin) in combination with one of the antihypoxants (piracetam, calcii pangamas, piriditol). The intensive chemotherapy promoted a decrease in duration of bacterial discharge, destruction discontimation, cavernous healing, reduced incidence rates of side effects. Metabolic processes characterizing lipid peroxidation and redox improved.
authors.forename: M M
authors.initials: MM
authors.lastname: Savula
authors.forename: N S
authors.initials: NS
authors.lastname: Kravchenko
authors.forename: A I
authors.initials: AI
authors.lastname: Poznanskiĭ
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002125:Calcium Gluconate; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D034442:N-substituted Glycines; D010889:Piracetam / Q000627:therapeutic use*; D011437:Propylamines; D011746:Pyrithioxin / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D034442:N-substituted Glycines; D011437:Propylamines; D014803:Vitamin B Complex; D011746:Pyrithioxin; C105565:pangamic acid; D002125:Calcium Gluconate; D010889:Piracetam
vernacular_title: Khimioterapiia destruktivnogo tuberkulëza lëgkikh s primeneniem antioksidantov i antigipoksantov.