Chromosomal assignment of the gene for protein tyrosine phosphatase HPTP delta.
Protein tyrosine phosphatase (PTP) negatively regulates the effect of protein tyrosine kinases and is implicated in the regulation of a variety of biological phenomena such as cell activation, differentiation and neoplastic transformation. To gain insight into the role of PTPs, we cloned the human receptor-type PTP gene and assigned the chromosome harboring the gene for HPTP delta by using DNAs from human-mouse hybrid cell lines and by fluorescence in situ hybridization. The results clearly demonstrated that HPTP delta gene maps to human chromosome 9p24.
Hasegawa
K
K
Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience.
Ariyama
T
T
Inazawa
J
J
Mizuno
K
K
Ogimoto
M
M
Katagiri
T
T
Yakura
H
H
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D009693:Nucleic Acid Hybridization; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*
D017027:Protein Tyrosine Phosphatases