Evidence for sustained platelet activation in patients with early postinfarction angina.
Excretion of 2,3-dinor-thromboxane B2 released from activated platelets has been found elevated in patients with acute myocardial infarction and unstable angina. To investigate the role of thrombotic activity in postinfarction angina we measured urinary concentrations of 2,3-dinorthromboxane B2 in 20 patients over 10 days after myocardial infarction. Compared with 11 patients recovering pain-free, excretion of 2,3-dinorthromboxane B2 was found elevated in 9 patients who developed postinfarction angina. Accordingly, early postinfarction angina appears to be associated with ongoing thrombotic activity.
Hofmann
D
D
Department of Cardiology, University Hospital Hamburg, Germany.
Hamm
C W
CW
Lorenz
R L
RL
Terres
W
W
Weber
P C
PC
D000368:Aged; D000787:Angina Pectoris / Q000209:etiology / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D015539:Platelet Activation / Q000502:physiology*; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D013997:Time Factors
D013929:Thromboxane B2; C028965:2,3-dinor-thromboxane B2