title: New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis.
abstract: Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.
authors.affiliation: Department of Rheumatology, University of Manchester, UK.
authors.forename: E P
authors.initials: EP
authors.lastname: Das-Gupta
authors.forename: T J
authors.initials: TJ
authors.lastname: Lyons
authors.forename: J A
authors.initials: JA
authors.lastname: Hoyland
authors.forename: D M
authors.initials: DM
authors.lastname: Lawton
authors.forename: A J
authors.initials: AJ
authors.lastname: Freemont
mesh_terms: D000208:Acute Disease; D000375:Aging; D000818:Animals; D001842:Bone and Bones / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D002908:Chronic Disease; D004195:Disease Models, Animal; D005121:Extremities; D007596:Joints / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010003:Osteoarthritis / Q000473:pathology*; D010865:Pilot Projects; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000473:pathology