Induction of an humoral and cellular (auto) immune response to human and rat myeloperoxidase(MPO) in Brown-Norway(BN), Lewis and Wistar Kyoto(WKY) rat strains.
Anti-MPO and anti-proteinase 3 antibodies are strongly associated with certain forms of vasculitis and glomerulonephritis and a pathophysiological role for the antibodies has been hypothesized (Kallenberg et al. 1991). To test this hypothesis WKY, Lewis and BN rats were immunized with human MPO. BN rats developed a strong humoral response, cross reacting with autologous MPO, and Lewis rats a strong cellular response to human MPO.
Brouwer
E
E
Dept. Clinical Immunology, University Hospital, Groningen, The Netherlands.
Weening
J J
JJ
Klok
P A
PA
Huitema
M G
MG
Tervaert
J W
JW
Kallenberg
C G
CG
D000818:Animals; D000906:Antibodies / Q000097:blood; D000917:Antibody Formation; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D009195:Peroxidase / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011921:Rats, Inbred WKY
D000906:Antibodies; D009195:Peroxidase