title: Sneddon's syndrome with anticardiolipin antibodies--complications and treatment.
abstract: We investigated 2 patients with Sneddon's syndrome, elevated anticardiolipin antibodies and systemic complications, which included stroke, habitual abortions, cardiac valvular lesions, acrocyanosis, hypertension and renal insufficiency. Treatment with a combination of immunosuppressive agents and warfarin or aspirin prevented further complications and improved renal function. It is important for those in different specialties to be aware of this potentially treatable disorder.
authors.affiliation: Department of Neurology, University of Pretoria.
authors.forename: B P
authors.initials: BP
authors.lastname: Lotz
authors.forename: C M
authors.initials: CM
authors.lastname: Schutte
authors.forename: P F
authors.initials: PF
authors.lastname: Colin
authors.forename: L D
authors.initials: LD
authors.lastname: Biermann
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D002544:Cerebral Infarction / Q000209:etiology; D003490:Cyanosis / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D017445:Skin Diseases, Vascular / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D013577:Syndrome; D014034:Toes / Q000098:blood supply
chemical_list: D017153:Antibodies, Anticardiolipin; D011241:Prednisone