title: Inhibition of mutagenicity in Salmonella typhimurium by Glycyrrhiza glabra extract, glycyrrhizinic acid, 18 alpha- and 18 beta-glycyrrhetinic acids.
abstract: The effects of Glycyrrhiza glabra L. extract, glycyrrhizinic acid, 18 alpha- and 18 beta-glycyrrhetinic acids on the mutagenicity of the ethyl methanesulfonate, N-methyl-N'-nitro-N-nitrosoguanidine, and ribose-lysine Maillard model systems were investigated by using the Salmonella/microsome reversion assay. The protocol used allowed us to detect desmutagenic and antimutagenic activity and to avoid false positive results due to toxicity. For all the compounds tested, no desmutagenic activity was observed against ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine; only Glycyrrhiza glabra extract showed antimutagenic activity against ethyl methanesulfonate. On using the ribose-lysine mutagenic browning mixture, the desmutagenic activities of the Glycyrrhiza glabra extract, glycyrrhizinic acid, 18 alpha- and 18 beta-glycyrrhetinic acids were observed. 18 beta-Glycyrrhetinic acid was the most active compound. Glycyrrhiza glabra extract also exhibited antimutagenic activity against ribose-lysine.
authors.affiliation: Dipartimento Farmaceutico, Facoltà di Farmacia, Università di Parma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Zani
authors.forename: M T
authors.initials: MT
authors.lastname: Cuzzoni
authors.forename: M
authors.initials: M
authors.lastname: Daglia
authors.forename: S
authors.initials: S
authors.lastname: Benvenuti
authors.forename: G
authors.initials: G
authors.lastname: Vampa
authors.forename: P
authors.initials: P
authors.lastname: Mazza
mesh_terms: D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D019695:Glycyrrhizic Acid; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D010936:Plant Extracts; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid