title: Effectiveness of cyclophosphamide pulse treatment in Wegener's granulomatosis.
abstract: 43 patients with Wegener's granulomatosis were studied to evaluate the effectiveness of cyclophosphamide (cyc) pulse treatment. 42% of the patients showed benefits from treatment for at least 6 months after the cessation of cyc pulses. Analysis of clinical and laboratory parameters indicate that this treatment is less effective in patients in whom more than 4 organ systems are involved. Responders to the treatment showed disease manifestations predominantly in the ENT and lower respiratory tract and had lower cANCA titers (< 1:64) prior to treatment.
authors.affiliation: Department of Clinical Rheumatology, Medical University at Lübeck, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Reinhold-Keller
authors.forename: J
authors.initials: J
authors.lastname: Kekow
authors.forename: A
authors.initials: A
authors.lastname: Schnabel
authors.forename: M
authors.initials: M
authors.lastname: Schwarz-Eywill
authors.forename: W H
authors.initials: WH
authors.lastname: Schmitt
authors.forename: W L
authors.initials: WL
authors.lastname: Gross
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D003520:Cyclophosphamide