[The prognostic significance of pre-existing lymphocytotoxic antibodies in cadaveric kidney allografts with a negative specific crossmatch].
The paper presents the results obtained on preexisting lymphocytotoxic antibodies in 110 patients with the use of cryopreserved donor lymphocytes. Preexisting antibodies (PA) are shown to display in 52% of primary patients in the nephrological department. Follow-up measurements gave evidence on PA levels fluctuations following an undulating form. The analysis of the transplants 3-month survival in the negative cross-match indicated a better prognosis in those patients who showed antibodies to none of the donors. The presence of lymphocytotoxic reactions even of nondonor specificity, on the contrary, made the prognosis much worse.
Kharlamova
L A
LA
Zemlianitskaia
T L
TL
Makhlin
N V
NV
Iankovoĭ
D000961:Antilymphocyte Serum / Q000097:blood*; D002102:Cadaver; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000097:blood; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D011379:Prognosis; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D006680:HLA Antigens
Prognosticheskoe znachenie predsushchestvuiushchikh limfotsitotoksicheskikh antitel pri allotransplantatsiiakh trupnoĭ pochki s otritsatel'nym spetsificheskim kross-matchem.