Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).
Pavlovic
M
M
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Leffert
J J
JJ
Russello
O
O
Bunni
M A
MA
Beardsley
G P
GP
Priest
D G
DG
Pizzorno
G
G
D001665:Binding Sites; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D002460:Cell Line; D004351:Drug Resistance; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000378:metabolism*; D005493:Folic Acid Antagonists / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008727:Methotrexate / Q000378:metabolism; D010453:Peptide Synthases / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013763:Tetrahydrofolates / Q000378:metabolism / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists; D011956:Receptors, Cell Surface; D013763:Tetrahydrofolates; C045894:lometrexol; D005492:Folic Acid; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate