title: Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat.
abstract: 1. Sex differences observed in the metabolism of pentachlorothioanisole in rat were due to: (1) greater excretion in urine by females, and greater biliary excretion by males; (2) formation of pentachlorophenyl mercapturic acid pathway metabolites by females; and (3) redox-cycling between methylthio and methylsulphoxyl oxidation congeners in intermediary metabolites by females. 2. Three methylthio-turnover processes are proposed in the intermediary metabolism of pentachlorothioanisole.
authors.affiliation: US Department of Agriculture, Biosciences Research Laboratory, Fargo, ND 58105.
authors.forename: J E
authors.initials: JE
authors.lastname: Bakke
authors.forename: D J
authors.initials: DJ
authors.lastname: Mulford
authors.forename: J K
authors.initials: JK
authors.lastname: Huwe
authors.forename: V J
authors.initials: VJ
authors.lastname: Feil
authors.forename: K L
authors.initials: KL
authors.lastname: Davison
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D002722:Chlorobenzenes / Q000378:metabolism* / Q000652:urine; D004350:Drug Residues; D005260:Female; D005978:Glutathione / Q000502:physiology*; D008297:Male; D008745:Methylation; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D013438:Sulfhydryl Compounds / Q000378:metabolism*
chemical_list: D002722:Chlorobenzenes; D013438:Sulfhydryl Compounds; C031281:pentachloromethylthiobenzene; D005978:Glutathione