title: [Method of isolating carbamazepine from cadaveric material and its determination by fluorescent polarization immunoassay].
abstract: Optimal conditions for carbamazepine isolation from cadaveric liver have been determined. The authors recommend the material infusion with alcohol acidified with sulfuric acid to pH 1 three times for an hour. Conditions for measuring the isolated drug quantity have been developed. Fluorescent polarization immunoanalysis in the TDX system has been used for the first time. Carbamazepine detection limit for 50 g of the liver was found to be 2.5 x 10(-7) g.
authors.forename: A V
authors.initials: AV
authors.lastname: Shabalin
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Vergeĭchik
mesh_terms: D002102:Cadaver; D002220:Carbamazepine / Q000032:analysis / Q000302:isolation & purification*; D016231:Fluorescence Polarization Immunoassay / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000737:chemistry; D012995:Solubility
chemical_list: D002220:Carbamazepine
vernacular_title: Metodika izolirovaniia karbamazepina iz trupnogo materiala i opredeleniia ego metodom fliuorestsentno-poliarizatsionnogo immunoanaliza.