A controlled comparison of the effects of propranolol, benztropine, and placebo on akathisia: an interim analysis.
A group of 28 patients was treated to compare the effects on akathisia of the following: propranolol (80 mg/day), benztropine (6 mg/day), or placebo. Both propranolol and benztropine significantly improved akathisia by Day 3-5 of treatment. Placebo had no significant effects of akathisia. Three patients developed confusion or forgetfulness by Day 3 of benztropine treatment; these effects cleared upon discontinuation of benztropine.
Adler
L A
LA
Psychiatry Service, New York Department of Veterans Affairs Medical Center, NY 10010.
Peselow
E
E
Rosenthal
M
M
Angrist
B
B
D000328:Adult; D000368:Aged; D017109:Akathisia, Drug-Induced / Q000188:drug therapy*; D001590:Benztropine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use*; D016037:Single-Blind Method
D001590:Benztropine; D011433:Propranolol