title: Outcome of intra-abdominal infection in pigs depends more on host responses than on microbiology.
abstract: OBJECTIVE
  To assess the effects of mortality of the presence and proliferation of bacteria, and the host's response to infection, in pigs with peritonitis.
  
  
  METHODS
  Laboratory study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  71 Swedish Landrace pigs, 63 with peritonitis and 8 without (controls).
  
  
  METHODS
  Induction of peritonitis by intraperitoneal infusion of equal amounts of Escherichia coli and Bacteroides fragilis (10(9) to 10(11) bacteria/animal); sterile faeces were added in half the experiments.
  
  
  METHODS
  Microbiological events were quantified as the area under the bacterial concentration curve from 0-6 hours. Host responses were quantified with a score of 8 physiological variables measured between 4-6 hours after the induction of peritonitis.
  
  
  RESULTS
  Of the 63 infected animals, 37 (59%) died within 6-24 hours and both the physiological response and the bacterial load were significantly higher in those that died. Logistic regression analysis with death as the dependent variable showed that the physiology score carried more predictive information than the quantification of bacterial load.
  
  
  CONCLUSIONS
  The quantification of local events within the abdomen is of only limited predictive value compared with the extent of the physiological alterations.
authors.affiliation: Department of Surgery, Linköping University Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Jönsson
authors.forename: J
authors.initials: J
authors.lastname: Berglund
authors.forename: T
authors.initials: T
authors.lastname: Skau
authors.forename: P O
authors.initials: PO
authors.lastname: Nyström
mesh_terms: D000818:Animals; D001442:Bacteroides Infections / Q000382:microbiology / Q000503:physiopathology*; D001441:Bacteroides fragilis; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D004927:Escherichia coli Infections / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D008297:Male; D010538:Peritonitis / Q000382:microbiology* / Q000503:physiopathology*; D011379:Prognosis; D012044:Regression Analysis; D012720:Severity of Illness Index; D013552:Swine