[Effect of HLA- genotype on bacterial colonization and antigenemia in patients with infiltrative pulmonary tuberculosis].
150 patients with infiltrative tuberculosis (IT) and 135 healthy subjects were subjected to HLA-typing. Clinico-immunogenetic correlations provided evidence for significantly higher incidence of antigens A11, B12, Cw2, DR2, DR5 in IT patients versus healthy subjects. Antigens Cw3 and DR2 occur more frequently in progressive disease. IT patients disseminating M. tuberculosis carry more frequently antigens HLA-DR2, those with L-forms DR5, with antigenemia antigens HLA-DR2 and DR4.
Pospelov
L E
LE
Mikhaĭlova
I V
IV
D000328:Adult; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006680:HLA Antigens / Q000097:blood*; D015234:HLA-A Antigens / Q000097:blood; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens / Q000097:blood; D015236:HLA-C Antigens / Q000097:blood; D015802:HLA-DR2 Antigen / Q000097:blood; D015804:HLA-DR4 Antigen / Q000097:blood; D015805:HLA-DR5 Antigen / Q000097:blood; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy / Q000235:genetics*
D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens; C035015:HLA-B12 antigen; D015236:HLA-C Antigens; C048767:HLA-C*02 antigen; D015802:HLA-DR2 Antigen; D015804:HLA-DR4 Antigen; D015805:HLA-DR5 Antigen
Vliianie HLA-genotipa u bolńykh infiltrativnym tuberkulëzom lëgkikh na bakterialńuiu populiatsiiu i antigenemiiu.