[Effect of ethanol and lipid peroxidation on testosterone biosynthesis by interstitial cells of rat testes].
The induction of lipid peroxidation in interstitial cells of rat testes of ADP-Fe3+ complex results in the decrease of testosterone biosynthesis. Ethanol at 50 mM concentration enhances the level of malonic dialdehyde and inhibits the steroidogenesis. Effects of alcohol and ADP-Fe3+ complex both on lipid peroxidation or testosterone biosynthesis are additive. This agrees with the idea about the mediation of ethanol effects in testes by the induction of lipid peroxidation.
Khokha
A M
AM
Kashko
M F
MF
Voronov
P P
PP
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005290:Ferric Compounds / Q000494:pharmacology; D007985:Leydig Cells / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D013256:Steroids / Q000096:biosynthesis; D013739:Testosterone / Q000096:biosynthesis*
D005290:Ferric Compounds; D013256:Steroids; D000431:Ethanol; D013739:Testosterone; D008315:Malondialdehyde; D000244:Adenosine Diphosphate
Vliianie étanola i perekisnogo okisleniia lipidov na biosintez testosterona interstitsial'nymi kletkami semennikov krys.