Effect of iron deficiency anaemia and its treatment on single dose phenytoin bioavailability.
Iron deficiency is a common nutritional deficiency, which leads to structural functional and enzymatic changes in the body that may affect the pharmacokinetics of drugs. The present study in 7 normal volunteers and 8 adult male patients with iron deficiency anaemia (IDA) was done to investigate the effect of iron deficiency and its treatment with total dose iron (TDI) on the bioavailability of a single dose of phenytoin. Phenytoin bioavailability was investigated before and 3 and 28 days after TDI. The bioavailability parameters Cmax, tmax, AUC and 2 h phenytoin concentrations were not significantly different in anaemic patients as compared to normal volunteers before or after treatment, except for an increase in tmax 28 days after TDI treatment.
Joshi
M V
MV
Department of Pharmacology, Seth G.S. Medical College and K.E.M. Hospital, Parel, Bombay, India.
Pohujani
S M
SM
Mehta
B C
BC
Acharya
V N
VN
Kshirsasgar
N A
NA
D000328:Adult; D000747:Anemia, Hypochromic / Q000188:drug therapy* / Q000378:metabolism; D001682:Biological Availability; D001810:Blood Volume; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D008297:Male; D009747:Nutritional Physiological Phenomena; D010672:Phenytoin / Q000493:pharmacokinetics*
D010672:Phenytoin; D007501:Iron