Myenteric neuron number after acute and chronic denervation of the proximal jejunum induced by benzalkonium chloride.
The effects of benzalkonium chloride (BAC) on the number of myenteric neurons after acute (until 10 days after BAC application) and chronic (30 and 60 days after BAC application) denervation of the proximal jejunum were determined in rats. There was a significant reduction in the number of myenteric neurons of all segments treated with BAC. The extent of denervation varied with time, and it was reduced in the denervated segments of the chronic group in comparison with the acute group. This may be due to the neuroplasticity phenomenon appearing during the chronic phase.
Ramalho
F S
FS
Department of Pathology, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Santos
G C
GC
Ramalho
L N
LN
Kajiwara
J K
JK
Zucoloto
S
S
D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D003714:Denervation; D007583:Jejunum / Q000187:drug effects / Q000294:innervation*; D008297:Male; D009197:Myenteric Plexus / Q000166:cytology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001548:Benzalkonium Compounds