[An experimental model of the vertical transmission of the Coxsackie-group enteroviruses and its use in developing methods to prevent congenital coxsackievirus infection].
An experimental model of vertical transmission of Coxsackie group enteroviruses was developed in BALB/c mice the first generation of which was infected with Coxsackie A18 virus in the neonatal period. Persistence of the virus was demonstrated in all females of the first generation tested and in 90.9% to 100% of the animals of the next two generations. Cytochemical analysis of the enzyme status of lymphocytes revealed reliable relationship between the depression of energetic metabolism enzymes and the activity of virus amplification in the animals under study. The correction of aerobic respiration in pregnant females by administration of a complex of energy metabolism substrates and cofactors was accompanied by a significant reduction of the virus infection activity in the females and their offsprings as well as by prevention of transplacental infection in some litters. The experimental model of vertical transmission of enteroviruses is proposed for use in the development of methods for prevention of congenital Coxsackie virus infection. The authors express their deep gratitude to the sponsor of the publication--NOVRUZ Co., Turkmenistan.
Lozovskaia
L S
LS
Zubkova
I V
IV
Khellenov
E A
EA
Shishchenko
V M
VM
Konopleva
T N
TN
D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000032:analysis; D002908:Chronic Disease; D003384:Coxsackievirus Infections / Q000151:congenital / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission*; D004195:Disease Models, Animal; D004734:Energy Metabolism; D004770:Enterovirus / Q000276:immunology / Q000302:isolation & purification; D005260:Female; D006651:Histocytochemistry; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000956:Antigens, Viral
Eksperimental'naia model' vertikal'noĭ peredachi énterovirusov gruppy Koksaki i ee ispol'zovanie pri razrabotke metodov profilaktiki vrozhdennoĭ Koksaki-virusnoĭ infektsii.