title: Chromosomal assignment of the gene for protein tyrosine phosphatase HPTP delta.
abstract: Protein tyrosine phosphatase (PTP) negatively regulates the effect of protein tyrosine kinases and is implicated in the regulation of a variety of biological phenomena such as cell activation, differentiation and neoplastic transformation. To gain insight into the role of PTPs, we cloned the human receptor-type PTP gene and assigned the chromosome harboring the gene for HPTP delta by using DNAs from human-mouse hybrid cell lines and by fluorescence in situ hybridization. The results clearly demonstrated that HPTP delta gene maps to human chromosome 9p24.
authors.affiliation: Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience.
authors.forename: K
authors.initials: K
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Ariyama
authors.forename: J
authors.initials: J
authors.lastname: Inazawa
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: M
authors.initials: M
authors.lastname: Ogimoto
authors.forename: T
authors.initials: T
authors.lastname: Katagiri
authors.forename: H
authors.initials: H
authors.lastname: Yakura
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D009693:Nucleic Acid Hybridization; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*
chemical_list: D017027:Protein Tyrosine Phosphatases