title: [Essential thrombocythemia. Apropos a case of cerebrovascular stroke].
abstract: The authors report the case of a 60-year-old white man with a previous history of pulmonary tuberculosis, smoking habits, hypertension, intermittent claudication and erythromelalgia, admitted to our ward with an ischemic cerebral event. Initial laboratory evaluation documented thrombocytosis (platelet-950000/mm3) and discrete anemia. Additional studies confirmed the diagnosis of essential thrombocythemia, meeting all the criteria proposed by the Polycythemia Vera Study Group in 1986, after exclusion of the possible causes of reactive thrombocytosis. Therapy was initiated with alpha-2b interferon (3 MU/m2 subcutaneously three times a week) and aspirin. Platelet count control was obtained and the patient remained asymptomatic. Nine months later cutaneous toxicity obliged the discontinuance of alpha-interferon. Due to a continuous increase of platelet count, hydroxyurea was introduced. The patient is asymptomatic, with platelet counts < 500000/mm3, without toxicity manifestations, two years after diagnosis. The contribution of cardiovascular risk factors versus thrombocythemia in the pathogenesis of the ischemic cerebral event and the benefit of platelet count control are discussed.
authors.affiliation: Serviço de Medicina I, Hospital Universitário de Santa Maria, Lisboa.
authors.forename: A S
authors.initials: AS
authors.lastname: Oliveira
authors.forename: M P
authors.initials: MP
authors.lastname: Miranda
authors.forename: P C
authors.initials: PC
authors.lastname: Duarte
authors.forename: J N
authors.initials: JN
authors.lastname: Sarmento
mesh_terms: D001241:Aspirin / Q000008:administration & dosage; D002561:Cerebrovascular Disorders / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011994:Recombinant Proteins; D013920:Thrombocythemia, Essential / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D013997:Time Factors
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D001241:Aspirin
vernacular_title: Trombocitemia essencial. A propósito de um caso de acidente vascular cerebral.