Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.
Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.
Nishimura
Y
Y
Institute of Microbial Chemistry, Tokyo, Japan.
Umezawa
Y
Y
Kondo
S
S
Takeuchi
T
T
Mori
K
K
Kijima-Suda
I
I
Tomita
K
K
Sugawara
K
K
Nakamura
K
K
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; D010880:Piperidines; D014764:Viral Proteins; C011353:siastatin; D009439:Neuraminidase