[Continuous infusion of vancomycin in post-neurosurgical staphylococcal meningitis in adults].
Eight adult patients with post-surgery meningitis caused by methicillin-resistant staphylococci were treated with continuous intravenous infusion of vancomycin in mean doses of 50 mg/kg/day. This treatment, which lasted 3 to 6 weeks, was well tolerated by the kidneys and resulted in cure in all cases; its effect on the ear was not evaluated. Stable concentrations of 4 to 7 mg/l in cerebrospinal fluid were obtained after the 48th hour of treatment.
Brinquin
L
L
Service de Réanimation, HIA du Val-de-Grâce, Paris.
Rousseau
J M
JM
Boulesteix
G
G
Diraison
Y
Y
Bonsignour
J P
JP
D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D008875:Middle Aged; D009493:Neurosurgery; D011183:Postoperative Complications; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013212:Staphylococcus epidermidis / Q000302:isolation & purification*; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*
D014640:Vancomycin
Vancomycine en perfusion continue dans les méningites à staphylocoques post-neurochirurgicales de l'adulte.