Basic evaluation of 67Ga labeled digoxin derivative as a metal-labeled bifunctional radiopharmaceutical.
To develop metal-labeled digoxin radiopharmaceuticals with affinity with anti-digoxin antibody as well as Na+,K(+)-ATPase, a digoxin derivative conjugated with deferoxamine was synthesized. The derivative had a high binding affinity with 67Ga at deferoxamine introduced to the terminal sugar ring of digoxin. The 67Ga labeled digoxin derivative showed enough in vitro binding affinity and selectivity to anti-digoxin antibody as well as Na+,K(+)-ATPase. The 67Ga labeled digoxin derivative is considered to be a potential metal-labeled bifunctional radiopharmaceutical for digoxin RIA as well as myocardial Na+,K(+)-ATPase imaging.
Fujibayashi
Y
Y
School of Medicine, Kyoto University, Japan.
Takemura
Y
Y
Taniuchi
H
H
Iijima
N
N
Konishi
J
J
Yokoyama
A
A
D003432:Cross-Linking Reagents; D003676:Deferoxamine; D004077:Digoxin; D005069:Evaluation Studies as Topic; D005710:Gallium Radioisotopes; D011849:Radioactive Tracers
D003432:Cross-Linking Reagents; D005710:Gallium Radioisotopes; D011849:Radioactive Tracers; D004077:Digoxin; D003676:Deferoxamine