Prevalence of anti-cardiolipin antibody in habitual aborters.
An enzyme-linked immunosorbent assay was developed for the detection of anticardiolipin antibody (ACA) in habitual aborters. Results above the 98th percentile of a distribution of 100 blood donors were considered to be positive. Specific binding index for ACA was higher in 20 patients with at least 3 consecutive spontaneous abortions (group A) than in 20 women with at least one live birth without pregnancy wastage (group B). ACA was detected in 4 patients of group A and in none of the women of group B. Most of the pregnancy wastages occurred after the first trimester in ACA-positive patients and during the first trimester in ACA-negative patients.
Costa
H de L
Hde L
Department of Gynecology and Obstetrics, University Hospital, Faculty of Medicine of Ribeirão Preto, SP, Brazil.
de Moura
M D
MD
Ferriani
R A
RA
Anceschi
M I
MI
Barbosa
J E
JE
D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D008297:Male; D011247:Pregnancy; D012016:Reference Values
D017153:Antibodies, Anticardiolipin