title: Immunogenicity and safety of Haemophilus influenzae type b-tetanus protein conjugate vaccine alone or mixed with diphtheria-tetanus-pertussis vaccine in infants.
abstract: Haemophilus capsular polysaccharide-tetanus toxoid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 micrograms/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar. The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
authors.forename: S L
authors.initials: SL
authors.lastname: Kaplan
authors.forename: B A
authors.initials: BA
authors.lastname: Lauer
authors.forename: M A
authors.initials: MA
authors.lastname: Ward
authors.forename: B L
authors.initials: BL
authors.lastname: Wiedermann
authors.forename: K M
authors.initials: KM
authors.lastname: Boyer
authors.forename: C M
authors.initials: CM
authors.lastname: Dukes
authors.forename: D M
authors.initials: DM
authors.lastname: Schaffer
authors.forename: J
authors.initials: J
authors.lastname: Paisley
authors.forename: R
authors.initials: R
authors.lastname: Mendelson
authors.forename: F
authors.initials: F
authors.lastname: Pedreira
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D004165:Diphtheria / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D004359:Drug Therapy, Combination; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007223:Infant; D013742:Tetanus / Q000276:immunology*; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C055753:Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate