title: Platinum analogues in preclinical and clinical development.
abstract: The impact of cisplatin on chemotherapy for solid tumors has led to the synthesis of many molecules with platinum as their central building block. These so-called platinum analogues have been developed with the obvious goals of improving the antitumor activity of cisplatin and hopefully, at the same time, altering the dose-limiting side effects of the prototype drug. At least 10 such molecules are in clinical development, whereas several others are at various stages of preclinical testing.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.
authors.forename: T C
authors.initials: TC
authors.lastname: Hamilton
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Dwyer
authors.forename: R F
authors.initials: RF
authors.lastname: Ozols
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D002986:Clinical Trials as Topic; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D009944:Organoplatinum Compounds; D002945:Cisplatin