The effects of tick-borne fever on the susceptibility of ovine polymorphonuclear cells to P. haemolytica cytotoxin.
Tick-borne fever predisposes sheep to secondary infections by Pasteurella haemolytica. Polymorphonuclear (PMN) cells obtained from sheep 2 to 7 days after the onset of parasitaemia due to Cytoecetes phagocytophila, the causative agent of tick-borne fever, were significantly more susceptible in vitro to the cytotoxin of P. haemolytica than PMN obtained from age-matched control sheep.
Woldehiwet
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University of Liverpool, Department of Veterinary Pathology, Leahurst, Neston, Wirral, U.K.
Dare
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Carter
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SD
D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism / Q000494:pharmacology; D003603:Cytotoxins / Q000378:metabolism / Q000494:pharmacology; D004198:Disease Susceptibility; D005098:Exotoxins / Q000378:metabolism / Q000494:pharmacology*; D015994:Incidence; D016978:Mannheimia haemolytica / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D010272:Parasitic Diseases / Q000150:complications; D010273:Parasitic Diseases, Animal; D010326:Pasteurella Infections / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000209:etiology; D017282:Tick-Borne Diseases / Q000150:complications / Q000209:etiology / Q000662:veterinary*; D013997:Time Factors
D001427:Bacterial Toxins; D003603:Cytotoxins; D005098:Exotoxins; C018579:leukotoxin