title: [MRT of the liver in Wilson's disease].
abstract: To show that Wilson's disease is one likely cause of multiple low-intensity nodules of the liver we obtained MR images in 16 patients with clinically and histopathologically confirmed Wilson's disease. Corresponding to morphological changes MRI enabled the subdivision of the patients into two groups. Using a T2-weighted spin-echo sequence (TR/TE = 2000/45-90) liver parenchyma showed multiple tiny low-intensity-nodules surrounded by high-intensity septa in 10 out of 16 patients. 5 patients had also low-intensity nodules in T1-weighted images (TR/TE = 600/20). In patients of this group histopathology revealed liver cirrhosis (n = 7) and fibrosis (n = 2). Common feature of this patient group was marked inflammatory cell infiltration into fibrous septa, increase of copper concentration in liver parenchyma and distinct pathological changes of laboratory data. In the remaining 6 patients no pathological change of liver morphology was demonstrated by MRI corresponding to slight histopathological changes of parenchyma and normal laboratory data. As low-intensity nodules surrounded by high intensity septa can be demonstrated in patients with marked inflammatory infiltration of liver parenchyma MRI may help to define Wilson patients with poorer prognosis. In patients with low-intensity nodules of the liver and unknown cause of liver cirrhosis laboratory data and histopathology should be checked when searching for disorders of copper metabolism.
authors.affiliation: Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: S
authors.initials: S
authors.lastname: Steiner
authors.forename: R
authors.initials: R
authors.lastname: Hammerstingl
authors.forename: S
authors.initials: S
authors.lastname: Schwarz
authors.forename: E
authors.initials: E
authors.lastname: Kraft
authors.forename: M
authors.initials: M
authors.lastname: Weinzierl
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D005355:Fibrosis; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000453:epidemiology; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
vernacular_title: MRT der Leber bei Morbus Wilson.