Photic induction of Fos in the hamster suprachiasmatic nucleus is inhibited by baclofen but not by diazepam or bicucullin.
The present study makes use of the photic induction of Fos in the suprachiasmatic nucleus (SCN) to explore the pharmacology of retinal input to this circadian pacemaker. Our results demonstrate that the GABAA antagonist bicuculline and the benzodiazepine agonist diazepam, both of which prevent light-induced phase shifts, do not inhibit photic induction of Fos expression in the hamster SCN. In contrast, the GABAB agonist, baclofen, prevents both light-induced phase shifts and inhibits photic induction of Fos expression in the SCN. One explanation of this difference may be that baclofen acts to prevent photic information from reaching the SCN while bicuculline and diazepam act within the SCN at a point 'downstream' from Fos induction.
Colwell
C S
CS
Department of Biology, University of Virginia, Charlottesville 22903.
Kaufman
C M
CM
Menaker
M
M
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology*; D006224:Cricetinae; D003975:Diazepam / Q000494:pharmacology*; D016762:Genes, fos / Q000187:drug effects / Q000528:radiation effects; D008027:Light; D008297:Male; D008647:Mesocricetus; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects
D016760:Proto-Oncogene Proteins c-fos; D001418:Baclofen; D003975:Diazepam; D001640:Bicuculline