Stable chromosome aberrations 25 years after severe accidental radiation exposure.
A thorough cytogenetic analysis using G-banding was performed on 100 peripheral blood lymphocytes from an individual who had been accidentally exposed to radiation more than 25 years previously. More than 60% of the analysed cells were found to possess one or more stable chromosome aberrations (e.g. reciprocal translocations). Chromosomes 1 and 11 were more involved in these aberrations than would be expected from the relative chromosome lengths. No identical stable aberrations were found, suggesting that, 25 years after near-lethal exposure, haemopoietic stem cells display substantial diversity.
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Vlaamse Instelling voor Technologisch Onderzoek (V.I.T.O.), Division of Environmental Research, Mol, Belgium.
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Léonard
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Léonard
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D000059:Accidents; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects*; D004781:Environmental Exposure; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014178:Translocation, Genetic