title: Elatosides A and B, potent inhibitors of ethanol absorption in rats from the bark of Aralia elata Seem: the structure-activity relationships of oleanolic acid oligoglycosides.
abstract: By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata Seem. together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: E
authors.initials: E
authors.lastname: Harada
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
authors.forename: N
authors.initials: N
authors.lastname: Murakami
mesh_terms: D000042:Absorption / Q000187:drug effects; D000427:Alcohol Deterrents / Q000737:chemistry* / Q000302:isolation & purification; D000437:Alcoholism / Q000188:drug therapy; D000818:Animals; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009828:Oleanolic Acid / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000427:Alcohol Deterrents; D010936:Plant Extracts; D000431:Ethanol; D009828:Oleanolic Acid