title: Rheological features of erythrocytes in acute myocardial infarction.
abstract: There is evidence that oxidative insult plays a role in the development of acute myocardial infarction. Significance has also been attributed to changes in viscosity of the blood and in the deformability and aggregation of erythrocytes affecting their rheological behavior. In a group of patients with myocardial infarction we found a decreased erythrocyte filtration and an increased blood viscosity with no significant change in plasma viscosity. These changes were accompanied by alterations in the microviscosity of the erythrocyte membrane assessed by measuring the polarization of specific fluorescent molecules. From our data it is evident that there is an increase in the rigidity of the membrane at the lipid/protein boundary, with an associated increase in the fluidity of the deep lipid core of the membrane, while no changes were observed in the dynamic behavior of the membrane proteins. These physico-chemical perturbations in the membrane could be the basis for the decreased filtration of erythrocytes. We found, however, no evidence of lipid peroxidation in the erythrocyte membrane.
authors.affiliation: Department of Biomedical Sciences and Technology and Biometry, University of L'Aquila, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Tozzi-Ciancarelli
authors.forename: C
authors.initials: C
authors.lastname: Di Massimo
authors.forename: A
authors.initials: A
authors.lastname: Mascioli
authors.forename: E
authors.initials: E
authors.lastname: Tozzi
authors.forename: P
authors.initials: P
authors.lastname: Gallo
authors.forename: F
authors.initials: F
authors.lastname: Fedele
authors.forename: A
authors.initials: A
authors.lastname: Dagianti
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D001809:Blood Viscosity / Q000502:physiology*; D004907:Erythrocyte Deformability / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation; D008560:Membrane Fluidity / Q000502:physiology*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*
chemical_list: D000255:Adenosine Triphosphate