A new approach in the diagnosis and follow-up of bladder cancer. FISH analysis of urine, bladder washings, and tumors.
The aim of the present study was to ascertain whether fluorescence in situ hybridization (FISH) of urine could be a useful approach in bladder cancer. Herein, we present the cytogenetic and FISH findings in patients with and without bladder cancer. The samples examined with FISH consisted of urine, bladder washings, and tumor tissue, when available. The results obtained show that the FISH technique, particularly when used on urine, is a very useful tool in the diagnosis, early detection, and management of bladder cancer.
Meloni
A M
AM
SBRI of Genetrix, Inc., Scottsdale, Arizona 85251.
Peier
A M
AM
Haddad
F S
FS
Powell
I J
IJ
Block
A W
AW
Huben
R P
RP
Todd
I
I
Potter
W
W
Sandberg
A A
AA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000235:genetics / Q000652:urine; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000235:genetics / Q000652:urine; D002503:Centromere; D002869:Chromosome Aberrations; D015342:DNA Probes; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000235:genetics / Q000652:urine; D012680:Sensitivity and Specificity; D007507:Therapeutic Irrigation; D016482:Urinalysis / Q000379:methods*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000652:urine; D014556:Urine / Q000166:cytology
D015342:DNA Probes