The mammalian Na+/H+ exchanger gene family--initial structure/function studies.
A gene family of mammalian Na+/H+ exchangers has been identified. Three isoforms have been cloned, sequenced, and stably expressed, and structure/function studies have been begun. Several of the isoforms are found in the epithelia, and one of them is epithelial specific.
Tse
M
M
Levine
S
S
Yun
C
C
Brant
S
S
Pouyssegur
J
J
Donowitz
M
M
D000584:Amiloride / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D006801:Humans; D007082:Ileum / Q000378:metabolism; D015394:Molecular Structure; D005810:Multigene Family; D011817:Rabbits; D051381:Rats; D017923:Sodium-Hydrogen Exchangers / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014018:Tissue Distribution
D017923:Sodium-Hydrogen Exchangers; D000584:Amiloride