title: Pregnancy specific beta 1 glycoprotein (SP-1) in maternal serum and amniotic fluid; pre-eclampsia, small for gestational age fetus and fetal distress.
abstract: Pregnancy specific beta 1 glycoprotein (SP-1) levels have been suggested to correlate with certain obstetrical complications. We compared maternal serum SP-1 levels in normal pregnancies (N = 82), and pregnancies complicated by pre-eclampsia (N = 37), small for gestational age fetuses (N = 8) and fetal distress (N = 13). We also compared levels of this protein in mid-trimester amniotic fluid samples obtained from normal (N = 47) and small for gestational age fetuses (N = 25). Despite trends towards low maternal serum and amniotic fluid SP-1 values in complicated pregnancies, there were no statistically significant differences in their levels as compared with normal gestational age matched controls (P > 0.05). These data do not support the use of SP-1 values in clinical practice.
authors.affiliation: Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver.
authors.forename: R M
authors.initials: RM
authors.lastname: Silver
authors.forename: K D
authors.initials: KD
authors.lastname: Heyborne
authors.forename: K K
authors.initials: KK
authors.lastname: Leslie
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D005316:Fetal Distress / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy / Q000097:blood / Q000378:metabolism*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000378:metabolism*; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: D011268:Pregnancy-Specific beta 1-Glycoproteins