Combined effect of selected antiviral substances of natural and synthetic origin. II. Anti-influenza activity of a combination of a polyphenolic complex isolated from Geranium sanguineum L. and rimantadine in vivo.
The synergistic effect shown by the combination of a natural product, polyphenolic complex (PC) isolated from Geranium sanguineum L., and rimantadine (R) in vitro and in ovo [7], encouraged us to continue these studies by in vivo testing. A marked protective effect in experimental influenza virus A (H3N2) infection in mice was found when PC was applied nasally (i.n.) (1.0 mg/kg) only once 6 h before infection in combination with R applied orally in concentration 10.5 and 2.5 mg/kg 2h before and 2.24 and 48 h after viral inoculation (PI = 72.55%, 55% and 57.8% respectively).
Gegova
G
G
Institute of Microbiology, Bulgarian Academy of Sciences.
Manolova
N
N
Serkedzhieva
Iu
Iu
Maksimova
V
V
Uzunov
S
S
Dzeguze
D
D
Indulen
M
M
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005419:Flavonoids; D009980:Influenza A virus / Q000187:drug effects; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D010636:Phenols / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use*; D059808:Polyphenols; D012299:Rimantadine / Q000627:therapeutic use*; D013997:Time Factors
D000998:Antiviral Agents; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D059808:Polyphenols; D012299:Rimantadine