title: The effect of dentifrices containing Triclosan on the development of gingivitis in a 21-day experimental gingivitis study.
abstract: The aim of this study was to investigate the ability of Triclosan dentifrices to delay the development of gingivitis during a 21-day period without toothbrushing. Test pastes contained 0.3 per cent Triclosan; seven also contained 0.75 per cent zinc citrate; one other contained 2 per cent Gantrez. Plaque and gingivitis increased significantly (p < 0.001) between day 0 and day 21 in the control group. there was no evidence to reject the assumption of similar efficacy across the seven Triclosan/zinc citrate variants. For the combined Triclosan/zinc citrate groups, statistically significant reductions in plaque formation and in gingivitis relative to the control were recorded. Reductions in plaque and gingival bleeding compared to control for the Triclosan/Gantrez group were not statistically significant, although reductions in gingival indices were. The greater reduction in the Gingival Index of the Triclosan/zinc citrate group was also statistically significantly different from that of the Triclosan/Gantrez group, suggesting that a dentifrice containing the former would have a greater antigingivitis potential than a dentifrice containing the latter.
authors.affiliation: Unilever Dental Research, Port Sunlight Laboratory, Bebington, Wirral, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Saxton
authors.forename: E
authors.initials: E
authors.lastname: Huntington
authors.forename: D
authors.initials: D
authors.lastname: Cummins
mesh_terms: D000328:Adult; D002951:Citrates / Q000008:administration & dosage / Q000627:therapeutic use; D019343:Citric Acid; D003773:Dental Plaque / Q000517:prevention & control; D003802:Dentifrices; D004338:Drug Combinations; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008298:Maleates / Q000008:administration & dosage / Q000627:therapeutic use; D010512:Periodontal Index; D011145:Polyvinyls / Q000008:administration & dosage / Q000627:therapeutic use; D014260:Triclosan / Q000008:administration & dosage / Q000627:therapeutic use*; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D002951:Citrates; D003802:Dentifrices; D004338:Drug Combinations; D008298:Maleates; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D019343:Citric Acid; D014260:Triclosan; D015032:Zinc