In vitro and in vivo effects of quinidine on the kidneys in Fischer-344 rats.
Quinidine in vitro significantly reduced accumulation of TEA (tetraethyl ammonium) and PAH (p-amino hippurate) and inhibited oxygen consumption in renal cortical slices. Mitochondrial respiratory control index (RCI) and ADP/O ratio were decreased. Intraperitoneal administration of quinidine at 75 mg/kg twice a day for four days inhibited TEA transport in renal cortical slices and decreased oxygen consumption. Mitochondria showed a reduction in ADP/O ratio but no change in RCI. Serum biochemical measurements indicated a significant elevation in serum creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST).
Agarwal
A K
AK
Department of Sciences, John Jay College of CUNY, NY 10019.
Rao
S S
SS
D000618:Aminohippuric Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects* / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011802:Quinidine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000378:metabolism
D000618:Aminohippuric Acids; D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D011802:Quinidine