title: Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy.
abstract: Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56,PGK1).
authors.affiliation: Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City 84108.
authors.forename: P R
authors.initials: PR
authors.lastname: Fain
authors.forename: D F
authors.initials: DF
authors.lastname: Barker
authors.forename: P F
authors.initials: PF
authors.lastname: Chance
mesh_terms: D000328:Adult; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D014960:X Chromosome
chemical_list: D005819:Genetic Markers