title: ANCA in ocular inflammatory disorders.
abstract: 400 patients presenting with active inflammation of the conjunctiva, sclera, orbita, uvea or retina were cANCA negative during active disease, however, pANCA were found in 15%. Another group of 100 patients suffering from Wegener's granulomatosis (WG) showed in 72 cases one or multiple ocular inflammatory symptoms. They were frequently cANCA-positive. Contrary to some other reports dealing with ocular inflammation, we find a high specificity of cANCA for Wegener's granulomatosis and, therefore, recommend cANCA-testing in all ocular inflammatory disorders, which may be difficult to differentiate from a manifestation of WG.
authors.affiliation: Clinic for Ophthalmology, University of Kiel, FRG.
authors.forename: B
authors.initials: B
authors.lastname: Nölle
authors.forename: H
authors.initials: H
authors.lastname: Coners
authors.forename: G
authors.initials: G
authors.lastname: Duncker
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D003231:Conjunctivitis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005128:Eye Diseases / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D009916:Orbital Diseases / Q000276:immunology; D012164:Retinal Diseases / Q000276:immunology; D012171:Retinal Vessels; D015423:Scleritis / Q000276:immunology; D014605:Uveitis / Q000276:immunology; D014657:Vasculitis / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G