title: Short-term oral phosphate and bone remodeling in beagles.
abstract: Attempts to increase bone volume in osteoporotic patients are still in the experimental stage. The coherence therapy, proposed by Frost, suggests that the activated bone units can remodel bone matrix in tandem. The cells (i.e., osteoclast and osteoblast which compose the remodeling units) are manipulated through specific medications timed to each of their duration of actions. The current study was to examine the effect of withdrawal of oral phosphate on bone in ovariectomized dogs. The present report demonstrates the capability of short-term oral phosphate to activate bone remodeling in the ovariectomized animal model. Results from biochemical and histomorphometric analyses confirm that remodeling units are activated following the release of parathyroid hormone. This transient scenario inflicts a shift of mineral density distribution in cancellous bone matrix of the iliac crest. Nevertheless, the bone remodeling units appear to be synchronized with each other and thus their resorptive and formative phases should be amenable to further pharmacological manipulation.
authors.affiliation: Creative BioMolecules, Inc., Hopkinton, Massachusetts 01748.
authors.forename: M S
authors.initials: MS
authors.lastname: Shih
authors.forename: C
authors.initials: C
authors.lastname: Anderson
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D001857:Bone Matrix / Q000378:metabolism; D016723:Bone Remodeling / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000097:blood / Q000378:metabolism; D003720:Densitometry; D004285:Dogs; D005260:Female; D010052:Ovariectomy; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism; D010710:Phosphates / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium