Role of tetrahydrobiopterin in cytokine-stimulated metabolism of tryptophan and hydroxylation of arginine.
Milstien
S
S
Laboratories of Neurochemistry, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
Sakai
N
N
Kaufman
S
S
Saito
K
K
Heyes
M P
MP
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001708:Biopterins / Q000031:analogs & derivatives* / Q000378:metabolism; D002460:Cell Line; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology*; D006801:Humans; D006900:Hydroxylation; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D009000:Monocytes / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D011622:Pterins / Q000378:metabolism*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D016207:Cytokines; D011622:Pterins; D014409:Tumor Necrosis Factor-alpha; D001708:Biopterins; D009569:Nitric Oxide; D007371:Interferon-gamma; D014364:Tryptophan; D001120:Arginine; C003402:sapropterin