title: Low affinity nerve growth factor receptor, adrenal transplant and Parkinson's disease.
abstract: Immunohistochemistry of low-affinity nerve growth factor receptor (LNGFR) was performed postmortem in the striatum and the adrenal gland of a parkinsonian patient with an adrenal to brain transplantation. Few LNGFR-positive fibers were observed in the necrotic graft. By contrast numerous immunostained fibers were detected in a restricted zone of the host striatum adjacent to the graft, corresponding to a selective zone of sprouting of tyrosine hydroxylase-positive fibers. This suggests that nerve growth factor or related growth factors may promote sprouting of catecholaminergic fibers in the host striatum.
authors.affiliation: INSERM U 289, Hôpital de la Salpêtière, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Strada
authors.forename: E C
authors.initials: EC
authors.lastname: Hirsch
authors.forename: F
authors.initials: F
authors.lastname: Javoy-Agid
authors.forename: C
authors.initials: C
authors.lastname: Duyckaerts
authors.forename: J J
authors.initials: JJ
authors.lastname: Hauw
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
mesh_terms: D000313:Adrenal Medulla / Q000378:metabolism* / Q000473:pathology / Q000637:transplantation*; D001344:Autopsy; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D017475:Receptors, Nerve Growth Factor / Q000032:analysis / Q000378:metabolism*; D014182:Transplantation, Autologous; D016042:Transplantation, Heterotopic
chemical_list: D017475:Receptors, Nerve Growth Factor; D007980:Levodopa