[The frequencies of sister chromatid exchanges and chromosomal aberrations in the peripheral lymphocytes in patients with cervical carcinoma].
The study of the SCE frequencies and chromosome aberrations in 20 patients with cervical carcinoma and 20 cases of healthy women was carried out. The result showed that the SCE frequencies were as high as 9.28 +/- 0.34/cell in the patients with cervical cancer. They were significantly higher than those of the normal control group (P < 0.001). The chromosomal numerical changes and structural aberrations of the patients were much more than those of the normal women (P < 0.01). The important structural aberrations included ring chromosome, chromosomal restituation and breakage. Genetic instability and DNA repair level significantly suppressed in cancer patients were detected.
Xu
C F
CF
Nanjing Medical College.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D004260:DNA Repair; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008875:Middle Aged; D012303:Ring Chromosomes; D012854:Sister Chromatid Exchange; D002583:Uterine Cervical Neoplasms / Q000235:genetics*