Endothelial control of cell migration and proliferation.
The vascular endothelium was found to be involved in numerous physiological and pathophysiological processes and to act as a gating element in between cellular components of the blood and the adjacent tissue. In this respect, endothelial cells are especially important for the control of the extravasation of immune-competent cells and tumour cells and in tissue remodelling. These processes are guided by a network of intercellular recognition and transduction mechanisms in order to guarantee controlled, selective, target-directed action by extravasating cells and for complete functional remodelling of the adjacent tissue. Prostacyclin seems to play an important part in this endothelium-dependent intercellular crosstalk by modulating cell activation without altering the basal cellular mechanisms, as can be shown using stable prostacyclin mimetics, both in animal models and in cell culture.
Graf
H
H
Schering Research Laboratories, Berlin, Germany.
D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000502:physiology*; D011464:Epoprostenol / Q000502:physiology; D009000:Monocytes / Q000166:cytology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D009362:Neoplasm Metastasis / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000166:cytology
D011464:Epoprostenol