Hypercholesterolemia of copper deficiency is linked to glutathione metabolism and regulation of hepatic HMG-CoA reductase.
Copper deficiency in rats causes hypercholesterolemia and increases in hepatic glutathione concentration and HMG-CoA reductase activity. Prevention of the increase in hepatic glutathione abolished the other changes.
Bunce
G E
GE
Department of Biochemistry and Nutrition, Virginia Polytechnic Institute, Blacksburg 24061.
D000818:Animals; D003300:Copper / Q000172:deficiency*; D005978:Glutathione / Q000378:metabolism*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D006937:Hypercholesterolemia / Q000209:etiology*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D051381:Rats
D003300:Copper; D006903:Hydroxymethylglutaryl CoA Reductases; D005978:Glutathione