Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia.
Samples of iris ciliary body, choroid and retina from normal eyes and from 2 cases of sympathetic ophthalmitis (one acute and one late stage fibrosis) were examined for the expression of the VLA integrins beta 1 and alpha 1-6, and the integrin beta 3, in addition to ICAM-1, VCAM-1, ELAM-1 and CD44 using an APAAP staining technique. The expression of VLA-4, VLA-5, VCAM-1, ICAM-1, and CD44 was significantly increased and ELAM-1 was slightly increased in acute sympathetic ophthalmitis in comparison to fibrotic and normal eyes. VLA-6 was moderately increased in acute and fibrotic cases and VLA-2 VLA-3 and beta 3 were moderately expressed on all tissues examined. The differential expression of molecules known to be involved in lymphocyte activation and adhesion in acute sympathetic ophthalmitis suggests that certain adhesion molecules play a role in the pathogenesis of intraocular inflammation and may be suitable targets for immunotherapy.
Kuppner
M C
MC
Department of Ophthalmology, University of Aberdeen, Medical School, Foresterhill.
Liversidge
J
J
McKillop-Smith
S
S
Lumsden
L
L
Forrester
J V
JV
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002829:Choroid / Q000378:metabolism / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D007124:Immunoenzyme Techniques; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D009879:Ophthalmia, Sympathetic / Q000378:metabolism*; D012160:Retina / Q000378:metabolism / Q000473:pathology
D015815:Cell Adhesion Molecules