Comparative study: Replens versus local estrogen in menopausal women.
This was an open-label study comparing effects of a nonhormonal drug-free bioadhesive vaginal moisturizer to a local estrogen therapy in the treatment of vaginal dryness symptoms. There were 15 women evaluated in each treatment group during a 12-week period. Results indicated that the bioadhesive vaginal moisturizer was a safe and effective alternative to estrogen vaginal cream, with both therapies exhibiting statistically significant increases in vaginal moisture, vaginal fluid volume, and vaginal elasticity with a return of the premenopausal pH state.
Nachtigall
L E
LE
New York University School of Medicine, New York.
D000287:Administration, Topical; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids; D008593:Menopause; D008875:Middle Aged; D014621:Vagina / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014622:Vaginal Creams, Foams, and Jellies / Q000494:pharmacology / Q000627:therapeutic use*; D014623:Vaginal Diseases / Q000188:drug therapy*; D014626:Vaginal Smears
D004966:Estrogens, Conjugated (USP); D008055:Lipids; C085472:Replens; D014622:Vaginal Creams, Foams, and Jellies