title: [Neurocryptococcosis caused by nonencapsulated Cryptococcus neoformans].
abstract: The case of a patient with meningoencephafalitis due to a nonencapsulated strain of Cryptococcus neoformans is reported; he had no risk factors for the disease or AIDS. Clinical examination showed a chronic meningoencephalitis first diagnosed as tuberculosis. In the second cerebrospinal fluid (CSF) examination after a week from admission yeasts appeared inside macrophage cells. CSF culture in Sabouraud medium disclosed nonencapsulated Cryptococcus neoformans (biochemical identification). Sample inoculation in mouse (intraperitoneal) evidenced a capsule that disappeared in several consecutive cultures. The morphology of the yeast was studied by electronic microscopy. After treatment with amphotericin B and 5-fluorocytosine the patient had a favorable evolution. The significance of capsular material is discussed.
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Brasil.
authors.forename: C S
authors.initials: CS
authors.lastname: Lacaz
authors.forename: E M
authors.initials: EM
authors.lastname: Heins-Vaccari
authors.forename: N T
authors.initials: NT
authors.lastname: Melo
authors.forename: O A
authors.initials: OA
authors.lastname: Moreno-Carvalho
authors.forename: M L
authors.initials: ML
authors.lastname: Sampaio
authors.forename: L S
authors.initials: LS
authors.lastname: Nogueira
authors.forename: R J
authors.initials: RJ
authors.lastname: Badaró
authors.forename: J A
authors.initials: JA
authors.lastname: Livramento
mesh_terms: D000368:Aged; D003453:Cryptococcosis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D003455:Cryptococcus neoformans / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008855:Microscopy, Electron, Scanning
vernacular_title: Neurocriptococose por Cryptococcus neoformans não capsulado.