title: Successful treatment of coronary artery spasm following coronary artery bypass grafting.
abstract: A case of coronary artery spasm developed 6 hours after myocardial revascularization inducing both hemodynamic and electrocardiographic changes, is reported. The spasm was documented by coronary angiography, and it was not reversed by intracoronary infusion of isosorbide dinitrate. Intravenous infusion of nifedipine (initial dose of 0.0104 mg/min to final dose of 0.0208 mg/min), along with infusion of glyceronitrate (1.0 micrograms/kg/min) was able to significantly improve hemodynamic impairment and to reverse electrocardiographic changes in 12 hours. Coronary angiography, repeated in postoperative day 3, after 48 hours of continuous nifedipine infusion, showed a resolution of coronary spasm. There was no evidence of myocardial infarction as resulted from total CPK and MB isoenzyme release. Nifedipine infusion was gradually reduced as oral administration of slow release nifedipine (40 mg twice daily) was started. The combined intravenous infusion of glyceronitrate and nifedipine seems to be able to control and overcome coronary artery spasm following coronary surgery.
authors.affiliation: Istituto Malattie dell'Apparato Cardiovascolare e Respiratorio, Università degli Studi, IRCCS H San Raffaele, Milano.
authors.forename: F
authors.initials: F
authors.lastname: Donatelli
authors.forename: M A
authors.initials: MA
authors.lastname: Mariani
authors.forename: M
authors.initials: M
authors.lastname: Pocar
authors.forename: M
authors.initials: M
authors.lastname: Triggiani
authors.forename: S
authors.initials: S
authors.lastname: Pelenghi
authors.forename: A
authors.initials: A
authors.lastname: Grossi
mesh_terms: D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003329:Coronary Vasospasm / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D006801:Humans; D007262:Infusions, Intravenous; D007548:Isosorbide Dinitrate / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
chemical_list: D009543:Nifedipine; D007548:Isosorbide Dinitrate