Passive protection of mice against Actinobacillus pleuropneumoniae infection by monoclonal antibodies.
Mouse monoclonal antibodies (MAbs), Y-4b, F-6b and K-6a recognized as capsular antigens of A. pleuropneumoniae serotypes 1, 2 and 5, respectively, and MAb H-1b as lipopolysaccharide (LPS) of serotype 2 were produced. We examined the passive immunizing efficacy of these MAbs on A. pleuropneumoniae infection in C3H/HeJ mice. On the challenge infection of homologous serotype strains, they showed a sufficient protective effect in immunized mice. It was concluded that MAbs recognized as capsular antigen and LPS have a serotype-specific protective effect on A. pleuropneumoniae infection, suggesting the important role in preventing A. pleuropneumoniae infection.
Oishi
E
E
Division of Veterinary Microbiology, Kyoto Biken Laboratories, Japan.
Ito
H
H
Okabe
T
T
Terakado
N
N
D000189:Actinobacillus Infections / Q000276:immunology / Q000517:prevention & control*; D016977:Actinobacillus pleuropneumoniae / Q000145:classification / Q000472:pathogenicity; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D004797:Enzyme-Linked Immunosorbent Assay; D007116:Immunization, Passive; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D012703:Serotyping; D014774:Virulence
D000911:Antibodies, Monoclonal; D008070:Lipopolysaccharides