[Serum uric acid concentration and anticonvulsant therapy in childhood].
In antiepileptic treated adults a decrease of serum uric acid concentration was reported. In contrast to these findings we did not find a general decrease of uric acid concentration in 233 studied epileptic children and juveniles treated with antiepileptic drugs. But we found a significant decrease of uric acid concentration in epileptic children and juveniles treated with carbamazepine in monotherapy as well as in combined treatment. Rather increased uric acid serum concentration were found in primidone and valproate monotherapy. In the studied age groups only carbamazepine seems to be able to diminish uric acid concentration. The underlying mechanisms are unknown.
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Universitätskinderklinik, Neuropädiatrie und Klinische Chemie, Bonn.
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Liappis
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D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D014527:Uric Acid / Q000097:blood*
D000927:Anticonvulsants; D014527:Uric Acid
Harnsäureserumkonzentration und antiepileptische Therapie im Kindesalter.