title: The use of 5-fluorouracil in glaucoma filtration surgery.
abstract: Failure of glaucoma filtration surgery usually results from scarring at the surgical site. Studies have shown that fibroblast proliferation plays an important role in scar formation which results in a mechanical barrier to filtration (Gressel, Parris, & Folberg, 1984). Fibroblasts are immature collagen-producing cells which proliferate at the site of chronic inflammation. The antimetabolite 5-fluorouracil (5-FU) can inhibit fibroblast activity. Over the past ten years, the adjunctive use of 5-FU in filtration surgery has met with increased success and is particularly indicated in those patients at greatest risk of filtration failure.
authors.forename: F G
authors.initials: FG
authors.lastname: Langseth
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005347:Fibroblasts; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged
chemical_list: D005472:Fluorouracil