Analysis of sister chromatid exchange, micronucleus and chromosomal aberration frequencies in rodents exposed to mosquito coil smoke by inhalation route.
Mosquito coil smoke emitting from a mosquito repellent, was tested for its mutagenic effect in bone marrow cells from mouse and rat after 4 h acute inhalation exposure. Coil smoke with suspended particulate concentrations of 99-129 mg/m3, significantly elevated the frequencies of sister chromatid exchanges in bone marrow cells and micronuclei in polychromatic erythrocytes. Analysis of chromosomal aberrations in metaphases also revealed a significantly higher incidence of chromosomal aberration frequency in exposed rats and mice.
Moorthy
M V
MV
Department of Toxicology, Frederick Institute of Plant Protection and Toxicology, Padappai, India.
Murthy
P B
PB
D000280:Administration, Inhalation; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000187:drug effects; D007302:Insect Repellents / Q000633:toxicity*; D008677:Metaphase; D051379:Mice; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D051381:Rats; D017208:Rats, Wistar; D012854:Sister Chromatid Exchange; D012906:Smoke / Q000009:adverse effects*
D007302:Insect Repellents; D012906:Smoke