title: Folliculitis in Down's syndrome.
abstract: Twenty-two male and 20 female adults with Down's syndrome were examined. Ten of the men and two of the women had a follicular rash consistent with Malassezia folliculitis. Oral itraconazole treatment produced a significant improvement in the rash, accompanied by a decrease in the skin Malassezia count. Clinical relapse occurred when therapy was discontinued, and was accompanied by return of the Malassezia yeasts.
authors.affiliation: Department of Dermatology, Bristol Royal Infirmary, U.K.
authors.forename: G M
authors.initials: GM
authors.lastname: Kavanagh
authors.forename: J P
authors.initials: JP
authors.lastname: Leeming
authors.forename: G M
authors.initials: GM
authors.lastname: Marshman
authors.forename: N J
authors.initials: NJ
authors.lastname: Reynolds
authors.forename: J L
authors.initials: JL
authors.lastname: Burton
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004314:Down Syndrome / Q000150:complications* / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008290:Malassezia; D008297:Male; D012008:Recurrence; D012867:Skin / Q000473:pathology
chemical_list: D017964:Itraconazole