Characterization of the trehalose 6,6'-dimycolate surface monolayer by scanning tunneling microscopy.
The toxicity of trehalose 6,6'-dimycolate (TDM), a glycolipid of mycobacteria, requires presentation as a surface monolayer. Our model of the structure of the TDM monolayer was confirmed and extended by scanning tunneling microscopy. It consists of linear arrays with a periodicity of approximately 90 A (9 nm) that clustered in groups of four to form secondary structures with a periodicity of 360 A (36 nm).
Schabbing
R W
RW
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322.
Garcia
A
A
Hunter
R L
RL
D003311:Cord Factors / Q000737:chemistry*; D006801:Humans; D016252:Microscopy, Scanning Tunneling; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000737:chemistry / Q000472:pathogenicity; D014774:Virulence
D003311:Cord Factors