title: Influence of type and severity of pure forms of age-related cataract on visual acuity and contrast sensitivity. Italian American Cataract Study Group.
abstract: OBJECTIVE
  To compare the relationship between logMAR visual acuity (VA) and cataract severity and between contrast sensitivity (CS) and cataract severity in pure types of age-related lens opacities.
  
  
  METHODS
  Analysis included patients followed in the ongoing Italian-American Study of the Natural History of Age-Related Cataract. Lens opacities were classified and graded according to the Lens Opacities Classification System II (LOCS II). Visual acuity was measured with the Early Treatment Diabetic Retinopathy Study Chart. Contrast sensitivity was measured with the Pelli-Robson chart.
  
  
  RESULTS
  Data from 1,076 eyes were used for the analysis (366 clear lenses; 550, 124, and 36 eyes with cortical, nuclear and posterior subcapsular cataract, respectively). In age-adjusted analyses, increasing severity of all three cataract types was associated with progressively higher logMAR VA, which translates into poorer acuity, and lower CS scores. For both VA and CS, the effect of increasing severity was greatest for nuclear and least for cortical opacities. After adjusting for age and VA, CS scores were no longer associated with cataract type and severity, with the exception of advanced cortical opacities.
  
  
  CONCLUSIONS
  Increased cataract severity, as determined by LOCS II grading, is strongly associated with both VA and CS scores. Contrast sensitivity scores obtained from testing at low spatial frequency do not seem to offer additional information over standard VA testing in early cortical and posterior subcapsular opacities nor in nuclear cataracts.
authors.affiliation: Istituto di Oftalmologia, Università di Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Maraini
authors.forename: F
authors.initials: F
authors.lastname: Rosmini
authors.forename: P
authors.initials: P
authors.lastname: Graziosi
authors.forename: M C
authors.initials: MC
authors.lastname: Tomba
authors.forename: M
authors.initials: M
authors.lastname: Bonacini
authors.forename: R
authors.initials: R
authors.lastname: Cotichini
authors.forename: P
authors.initials: P
authors.lastname: Pasquini
authors.forename: R D
authors.initials: RD
authors.lastname: Sperduto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002386:Cataract / Q000145:classification / Q000503:physiopathology*; D015350:Contrast Sensitivity / Q000502:physiology*; D005260:Female; D006801:Humans; D007904:Lens Cortex, Crystalline / Q000503:physiopathology; D007907:Lens Nucleus, Crystalline / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity / Q000502:physiology*