Effects of topical application of UF-021, a novel prostaglandin-related compound, on aqueous humor dynamics in rabbit.
The mechanism underlying the intraocular pressure (IOP) lowering effect of a novel prostaglandin-related compound, (+)-isopropyl Z-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)-cyclopentyl]hept-5 -enoate (UF-021), and the influence of this new hypotensive agent on the permeability of the blood-aqueous barrier (BAB) were studied in albino rabbits. A single instillation of 0.06% UF-021 significantly lowered the IOP with a peak reduction of 5.2 mmHg without changing the aqueous flow rate. Uveoscleral outflow and outflow facility to general blood circulation were both increased. The BAB permeability evaluated with fluorescein isothiocyanate-labeled rabbit albumin (FITC-RA) showed approximately sixfold increase after a single instillation of 0.06% UF-021, which suggested a drug-induced compromise of the rabbit BAB.
Sakurai
M
M
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Araie
M
M
Oshika
T
T
Mori
M
M
Shoji
N
N
Masuda
K
K
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D001693:Biological Transport, Active; D001769:Blood / Q000378:metabolism; D001775:Blood Circulation; D002463:Cell Membrane Permeability / Q000187:drug effects; D015237:Dinoprost / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D016650:Fluorescein-5-isothiocyanate; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D011817:Rabbits; D012590:Sclera / Q000378:metabolism; D014602:Uvea / Q000378:metabolism
C072630:isopropyl unoprostone; D015237:Dinoprost; D016650:Fluorescein-5-isothiocyanate