Group II phospholipase A2 in sera of febrile patients with microbiologically or clinically documented infections.
Group II phospholipase A2 (PLA2-II) is an inflammatory enzyme, which has been shown to be an acute-phase protein and to correlate with the severity of sepsis. In a prospective study, the concentration of PLA2-II in the sera of 46 patients with sepsis and nonseptic bacterial and viral infections was measured by a fluoroimmunoassay. The serum concentration of PLA2-II in patients with infections (median, 164.5 micrograms/L; range, 5.07-1,740 micrograms/L) was elevated 46-fold above normal concentrations (median, 3.61 micrograms/L; range, 1.32-25.25 micrograms/L). The concentration of PLA2-II was higher in patients with sepsis (median, 284.5 micrograms/L; range, 12.95-1,574 micrograms/L) and nonseptic bacterial infections (median, 210.6 micrograms/L; range, 5.07-1,740 micrograms/L) than in those with viral infections (median, 46.78 micrograms/L; range 11.46-275.9 micrograms/L) (P = .0042). The concentration of PLA2-II correlated well with the concentration of C-reactive protein (CRP) (r = .613, P = .0001) but not with the concentration of pancreatic PLA2 (r = .089, P = .365). Measuring the serum concentration of PLA2-II is useful as an adjunct to the determination of CRP concentrations for differentiating bacterial from viral infection.
Rintala
E M
EM
Department of Medicine, University of Turku, Finland.
Nevalainen
T J
TJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D002097:C-Reactive Protein / Q000378:metabolism; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D005334:Fever / Q000201:enzymology; D016469:Fungemia / Q000097:blood / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D014777:Virus Diseases / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*
D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2