title: Quinacrine-induced pleural inflammation in malignant pleurisy: relation between drainage time of pleural fluid and local interleukin-1 beta levels.
abstract: In this study, the levels of interleukin-1 beta (IL-1 beta) were measured in pleural fluid from patients with chronic malignant pleural effusions, before and during quinacrine-induced pleurodesis. IL-1 beta levels increased significantly within 24 h after the instillation of quinacrine (p < 0.001). The levels of IL-1 beta correlated with the amount of pleural fluid production as well as with the tube drainage treatment time. Thus, the more IL-1 beta levels increased the higher pleural fluid production was seen and a longer drainage treatment time was needed. There were no correlations between IL-1 beta levels and degree of fever, recruitment of pleural leucocytes, activity of pleural coagulation or inhibition of pleural fibrinolysis.
authors.affiliation: Department of Thoracic Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
authors.forename: V
authors.initials: V
authors.lastname: Agrenius
authors.forename: V
authors.initials: V
authors.lastname: Ukale
authors.forename: O
authors.initials: O
authors.lastname: Widström
authors.forename: G
authors.initials: G
authors.lastname: Källenius
authors.forename: S B
authors.initials: SB
authors.lastname: Svenson
mesh_terms: D000328:Adult; D000368:Aged; D004322:Drainage; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007375:Interleukin-1 / Q000032:analysis*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010994:Pleura; D016066:Pleural Effusion, Malignant / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011796:Quinacrine / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D007375:Interleukin-1; D011796:Quinacrine