The host inflammatory response prior to death in patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection.
The intensity of the host inflammatory response to pulmonary infection with Pseudomonas aeruginosa immediately prior to death was determined in six patients with cystic fibrosis (CF). Plasma concentrations of neutrophil elastase alpha 1-antiproteinase, tumour necrosis factor-alpha (TNF alpha) and serum C-reactive protein (CRP) were increased in the 7 days prior to death (P < 0.05) when compared with a period of clinical stability during the preceding 6 months. An increased inflammatory response was sustained for many weeks prior to death and was associated with poor symptom and lung function responses to apparently appropriate antibiotic treatment.
Elborn
J S
JS
Section of Respiratory Medicine, University of Wales College of Medicine, Llandough Hospital, Penarth, U.K.
Cordon
S M
SM
Parker
D
D
Delamere
F M
FM
Shale
D J
DJ
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000097:blood*; D003643:Death; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000097:blood*; D019272:Leukocyte Elastase; D008297:Male; D010196:Pancreatic Elastase / Q000378:metabolism; D011552:Pseudomonas Infections / Q000097:blood*; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D000515:alpha 1-Antitrypsin; C037741:alpha 1-antitrypsin-leukocyte elastase complex; D002097:C-Reactive Protein; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase