A significant percentage of normal T lymphocytes express HLA-DP in the peripheral blood.
HLA-DP expression has been widely investigated on T lymphocytes activated under different conditions. In the present study, a double staining procedure was used in flow cytometric experiments to define DP expression on normal peripheral blood T lymphocytes. In about two-thirds of the case analyzed, DP was expressed on a higher percentage of normal peripheral T lymphocytes than DR was. This was particularly true for 1 of the 16 cases investigated in which the percentage of T lymphocytes expressing DP was 46% and in which DP expression was mainly the prerogative of CD8+ and CD56+ lymphocytes.
Baudeau
C
C
Centre Régional de Transfusion Sanguine, Strasbourg, France.
Falkenrodt
A
A
Parissiadis
A
A
Tongio
M M
MM
D015703:Antigens, CD / Q000032:analysis; D015415:Biomarkers; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006682:HLA-DP Antigens / Q000096:biosynthesis / Q000097:blood*; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D016130:Immunophenotyping; D008213:Lymphocyte Activation; D008297:Male; D016176:T-Lymphocyte Subsets / Q000378:metabolism*
D015703:Antigens, CD; D015415:Biomarkers; D006682:HLA-DP Antigens; D006684:HLA-DR Antigens