title: Effect of a sodium benzoate-sodium bicarbonate compound on dental plaque formation.
abstract: The objective of this study was to evaluate the effect of a sodium benzoate-sodium bicarbonate (SBSB) compound on dental plaque formation and developing gingivitis. Eighteen subjects were given a prophylaxis and instruction in oral hygiene to establish plaque-free conditions and gingival health for the study baseline. They were randomly divided into three groups. Each participant was instructed to rinse twice daily with either a 0.15% chlorhexidine digluconate solution, the SBSB compound, or a placebo solution for 21 days. They refrained from all other oral hygiene procedures during this period. Plaque, gingival, and stain indices were scored at baseline and at days 7, 14, and 21 during the rinsing protocol. A significant increase in plaque accumulation was observed for the SBSB compound and placebo groups in days 7 through 21. No increase in plaque accumulation was observed in the chlorhexidine group. An increase in gingival inflammation was observed in all groups, with no significant differences between groups. Significant increases in gingival bleeding occurrence compared to baseline were found in the chlorhexidine group by day 21, in the SBSB compound group by day 7, and in the placebo group by day 14. The present study did not disclose any plaque or gingivitis inhibiting effects of the SBSB compound.
authors.affiliation: Department of Dental Hygiene, Loma Linda University, CA.
authors.forename: D
authors.initials: D
authors.lastname: Ozanich
authors.forename: L
authors.initials: L
authors.lastname: Winn
authors.forename: N A
authors.initials: NA
authors.lastname: Medina
authors.forename: U M
authors.initials: UM
authors.lastname: Wikesjö
authors.forename: P
authors.initials: P
authors.lastname: Nygaard-Ostby
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001565:Benzoates / Q000627:therapeutic use*; D019817:Benzoic Acid; D002710:Chlorhexidine / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D008297:Male; D017693:Sodium Bicarbonate / Q000627:therapeutic use*
chemical_list: D001565:Benzoates; D017693:Sodium Bicarbonate; D019817:Benzoic Acid; D002710:Chlorhexidine