[Effect of slow action calcium channel inhibitors on the radioprotective effect of mezaton ].
Verapamil and cinnarizine decrease radioprotective effect of phenylephrine, but nifedipin (more specific inhibitor of slow calcium channel) doesn't change it. Consequently, protective effect of phenylephrine isn't realized by influx of Ca2+ ions through slow calcium channel.
Kulinskiĭ
V I
VI
Klimova
A D
AD
D000818:Animals; D002121:Calcium Channel Blockers / Q000378:metabolism*; D002936:Cinnarizine / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009543:Nifedipine / Q000378:metabolism; D010656:Phenylephrine / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000378:metabolism*; D013997:Time Factors; D014700:Verapamil / Q000378:metabolism
D002121:Calcium Channel Blockers; D011837:Radiation-Protective Agents; D010656:Phenylephrine; D002936:Cinnarizine; D014700:Verapamil; D009543:Nifedipine
Vliianie ingibitorov medlennykh kaltsievykh kanalov na radiozashchitnyĭ éffect mezatona.