title: [Acute carbamazepine poisoning treated with plasmapheresis. Description of a clinical case].
abstract: A case of severe Carbamazepine poisoning initially misdiagnosed is reported. Treatment consisted in plasmapheresis (3.5 liters exchanged) repeated for 3 consecutive days, in conjunction with activated charcoal and advanced life support. It was obtained a rapid decay in Carbamazepine plasmatic level (with rebound phenomenon only after first treatment day) and a contemporary improvement in clinical conditions. The patient was discharged without complications after 6 days stay in ICU. Taking pharmacokinetic characteristics into account, it is suggested that plasmapheresis may be useful in this kind of poisoning.
authors.affiliation: U.O. Anestesia e Rianimazione, USL 10/C, Nuovo Ospedale S. Giovanni di Dio, Firenze.
authors.forename: D
authors.initials: D
authors.lastname: Gambi
authors.forename: R
authors.initials: R
authors.lastname: Oggioni
authors.forename: V
authors.initials: V
authors.lastname: Mangani
authors.forename: M
authors.initials: M
authors.lastname: Librenti
authors.forename: F
authors.initials: F
authors.lastname: Manescalchi
authors.forename: G
authors.initials: G
authors.lastname: Tulli
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002220:Carbamazepine / Q000506:poisoning*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D011041:Poisoning / Q000503:physiopathology / Q000628:therapy
chemical_list: D002220:Carbamazepine
vernacular_title: Intossicazione acuta da carbamazepina trattata con plasmaferesi. Descrizione di un caso clinico.