title: Histomorphometric examination of healing around hydroxylapatite implants in 60Co-irradiated bone.
abstract: The purpose of this study was to histomorphometrically evaluate the use of hydroxylapatite (HA) implants in 60Co-irradiated bone. HA implants were installed in rabbit mandibles 3 months, 6 months, and 12 months after 15-Gy irradiation. Nonirradiated rabbits served as controls. The rabbits were killed 7, 14, 30, 60, and 90 days after the HA implantation. The histologic features of the healing process were examined and histomorphometric measurements were made to quantify the percentage of HA-bone contact and trabecular bone in the medullary cavity. In the irradiated groups, although HA-bone contact was observed later than that in the controls, recovery increased with time after irradiation and the rate of HA-bone contact bone-contacting implant surface ratio; BCSR exceeded 90% in all groups examined before 90 days. In the radiated groups, the average trabecular bone-specific volume was lower than that in the controls and began to decrease before BCSR exceeded 90%. Based on the present data, as well as data from the literature, it is suggested that the success rate of HA implants in irradiated bone increases with the interval after radiotherapy. It is also recommended that HA implants in irradiated bone be installed so that bearing by the cortical bone is increased.
authors.affiliation: School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsui
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Michi
authors.forename: T
authors.initials: T
authors.lastname: Tachikawa
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000528:radiation effects; D016723:Bone Remodeling / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D017886:Durapatite; D008297:Male; D008334:Mandible / Q000528:radiation effects*; D016348:Osseointegration / Q000528:radiation effects*; D019736:Prostheses and Implants; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D014945:Wound Healing / Q000528:radiation effects
chemical_list: D003037:Cobalt Radioisotopes; D017886:Durapatite