[The effect of epidermal growth factor on the growth potential of epithelial cells from human lens].
The growth promoting effect of epidermal growth factor (EGF) was studied in cultures of epithelial cells from human normal and cataractous lenses. The growth potential of lens epithelial cells was measured by MTT assay. The concentration of EGF in culture medium were classified into 7 groups (0 ng/ml-10(3) ng/ml). When the concentration of EGF was 1 ng/ml, EGF induced the highest increase of growth potential epithelial cells compared with an EGF-free group.
Majima
K
K
Department of Ophthalmology, Fujita Health University, School of Medicine, Toyoake, Japan.
Kousaka
M
M
D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000166:cytology* / Q000378:metabolism; D008875:Middle Aged
D004815:Epidermal Growth Factor; D066246:ErbB Receptors