Humoral hypercalcaemia in renal carcinoma due to parathyroid hormone related protein.
Parathyroid hormone related protein (PTHRP) has been implicated in humoral hypercalcaemia of malignancy (HHM). We describe a patient with a renal carcinoma and hypercalcaemia, and for the first time have demonstrated a 4-fold PTHRP concentration gradient across a renal tumour bed. This provides further strong evidence that the primary tumour was the source of the PTHRP. The PTHRP 1-86 content of the tumour tissue was 4.8 ng/g, similar to that previously found in tumours associated with HHM. In PTHRP-secreting tumours, PTHRP may be a useful oncological marker after surgical resection.
Sandhu
D P
DP
Department of Urology, Derbyshire Royal Infirmary.
Munson
K W
KW
Harrop
J S
JS
Hopton
M R
MR
Ratcliffe
W A
WA
D014408:Biomarkers, Tumor / Q000097:blood; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000502:physiology*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000502:physiology*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins