Reassessment of the value of post-vascularization biopsy performed at renal transplantation: the effects of arteriosclerosis.
Between January 1, 1984 and December 31, 1991, 471 cadaver renal transplants were performed. We reviewed 130 transplants, which were biopsied 30 minutes to 1 hour after the establishment of renal allograft blood flow. Analysis showed a significant difference in 2-year graft survival rate between the groups with and without arteriosclerosis (71.8% versus 65.9%, p < 0.05). Arteriosclerotic changes were noted more frequently in biopsies from older donors (37 versus 28 years, p < 0.005). There was also a difference in ischemic time between the groups with and without tubular degeneration (30.1 hours versus 26.7 hours, p < 0.02), which did not correlate with the need for dialysis in the perioperative period (48% versus 49%, p > 0.8).
Taub
H C
HC
Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Greenstein
S M
SM
Lerner
S E
SE
Schechner
R
R
Tellis
V A
VA
D000328:Adult; D001161:Arteriosclerosis; D001706:Biopsy; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D016030:Kidney Transplantation / Q000401:mortality / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D012189:Retrospective Studies; D015996:Survival Rate