2,4-Dimethyl-6 H-pyrido[3,2-b]carbazole, an isomer of the antitumor alkaloid ellipticine via the Combes-Beyer reaction.
The synthesis of 2,4-dimethyl-6 H-pyrido[3,2-b]carbazole (2a) and of its 9-methoxy (2b) and 9-hydroxy (2c) derivatives via the Combes-Beyer reaction is described. Pyridocarbazole 2a has been obtained by two different routes. In the course of the synthesis of 2b either a partial or a total demethoxylation has been observed depending on the route employed.
Alunni-Bistocchi
G
G
Istituto di Biochimica e Chimica Medica, Università degli Studi di Perugia, Italy.
Orvietani
P
P
Bittoun
P
P
Ricci
A
A
Lescot
E
E
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004611:Ellipticines / Q000138:chemical synthesis* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D004611:Ellipticines; C085560:2,4-dimethyl-6H-pyrido(3,2-b)carbazole