Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13.
Recently we isolated a cDNA clone corresponding to an epidermal serine proteinase inhibitor named SKALP (skin-derived antileukoproteinase). Here we report the chromosomal localization of the human gene encoding SKALP by Southern blot analysis of a panel of human x hamster hybrid cell lines and by nonradioactive in situ hybridization on R-banded human lymphocyte chromosome spreads. The SKALP-encoding gene has been assigned the approved symbol PI3 by the Human Gene Mapping nomenclature committee.
Molhuizen
H O
HO
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
Zeeuwen
P L
PL
Olde Weghuis
D
D
Geurts van Kessel
A
A
Schalkwijk
J
J
D000818:Animals; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D006224:Cricetinae; D053492:Elafin; D004817:Epidermis / Q000201:enzymology*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D015842:Serine Proteinase Inhibitors / Q000235:genetics*
D053492:Elafin; C506806:PI3 protein, human; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D015842:Serine Proteinase Inhibitors