title: Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in northern India.
abstract: Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.
authors.affiliation: Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.
authors.forename: N K
authors.initials: NK
authors.lastname: Mehra
authors.forename: I
authors.initials: I
authors.lastname: Pande
authors.forename: V
authors.initials: V
authors.lastname: Taneja
authors.forename: S S
authors.initials: SS
authors.lastname: Uppal
authors.forename: S P
authors.initials: SP
authors.lastname: Saxena
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: A N
authors.initials: AN
authors.lastname: Malaviya
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D007194:India / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D008285:Major Histocompatibility Complex
chemical_list: D006680:HLA Antigens