[Treatment of patients with stable angina by combination of trinitrolong and propranolol].
Trinitrolong (TNL), a long-acting nitroglycerin for application on the gingiva, was comparatively assessed for effect on stable angina pectoris in monotherapy and in combination with beta-adrenoblocker propranolol. A total of 11 anginal patients received the combination the efficacy of which was verified by paired bicycle ergometry. A high antianginal effect of TNL was established. However, its combination with propranolol entails neither higher exercise tolerance nor less frequent anginal attacks. An increment in the effect was not seen either when the combination was used in single and course doses in one-third of the patients.
Kukushkin
S K
SK
Metelitsa
V I
VI
Kokurina
E V
EV
Bochkarëva
E V
EV
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005080:Exercise Test / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology / Q000627:therapeutic use*; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D003692:Delayed-Action Preparations; D011433:Propranolol; D005996:Nitroglycerin
Lechenie bolńykh stabilńoĭ stenokardieĭ kombinatsieĭ trinitrolonga i propranolola.