[Role of nucleus accumbens in cardiovascular activities and its relationship with opioid peptides in rats].
In this study, electrical stimulation and microinjection in nucleus accumbens in urethane-anesthetized rats were conducted to observe the effect of electrical stimulation of nucleus accumbens on blood pressure and heart rate. The following results were observed: (1) Electrical stimulation of the nucleus accumbens of rat resulted in significant hypotension and bradycardia. (2) Kainic acid microinjected into the nucleus accumbens, could abolish the effects mentioned above. (3) Naloxone administered to the nucleus accumbens could block the cardiovascular inhibitory effect evoked by electrical stimulation of nucleus accumbens. The intra-accumbens injection of mu-receptor agonist, DAGO could also elicit hypotension and bradycardia to an extent comparable to that of the effect due to electrical stimulation, whereas kappa-receptor agonist, U-50 had no such an effect. (4) When the cardiovascular inhibitory effect elicited by electrical stimulation of the nucleus accumbens was observed, the discharge activity in locus ceruleus was also decreased. (5) Bilateral vagotomy could abolish the change in heart rate elicited by the electrical stimulation of nucleus accumbens, but not the hypotension. It is suggested that the mu-opioid receptors of neurons in nucleus accumbens are involved in cardiovascular activity.
Shen
S
S
Department of Physiology, Nanjing Medical College.
Zhu
S M
SM
Yuan
X R
XR
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology; D008125:Locus Coeruleus / Q000502:physiology; D008845:Microinjections; D009270:Naloxone / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017450:Receptors, Opioid, mu / Q000502:physiology
D004745:Enkephalins; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009270:Naloxone; D007608:Kainic Acid