Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase.
Ercikan
E
E
Program of Molecular Pharmacology, Memorial Sloan-kettering Cancer Center, New York, NY 10021.
Waltham
M
M
Dicker
A
A
Schweitzer
B
B
Bertino
J R
JR
D000595:Amino Acid Sequence; D000630:Aminopterin / Q000378:metabolism / Q000494:pharmacology; D003062:Codon; D005493:Folic Acid Antagonists / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007930:Leucine; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology; D016297:Mutagenesis, Site-Directed; D016133:Polymerase Chain Reaction / Q000379:methods; D011743:Pyrimidines / Q000378:metabolism / Q000494:pharmacology; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000378:metabolism*
D003062:Codon; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D011994:Recombinant Proteins; D013762:Tetrahydrofolate Dehydrogenase; D007930:Leucine; D000630:Aminopterin; C024530:piritrexim; D008727:Methotrexate