title: Conformal radiotherapy of the pelvis: assessment of acute toxicity.
abstract: During the last 3 years the Royal Marsden Hospital (RMH) has conducted a prospective randomised trial of conformal pelvic radiotherapy in which dose/volume data and acute toxicity scores have been determined prospectively. Pending completion of the trial, a preliminary analysis has been undertaken of the volume reductions achieved, and of some of the symptom scores. The average symptom score increased during radiotherapy, more markedly for bowel than bladder symptoms. In comparing total doses of 30-38 Gy with 56-65 Gy, watery bowel motions were more frequent with the higher doses (p = 0.013) but in the high-dose group neither this symptom nor tenesmus correlated with volume of rectum treated to at least 90% of the prescribed dose. We conclude that the assessment of the impact of volume on the level of acute symptoms in pelvic radiotherapy is complex, and requires analysis of a range of symptoms, dose levels and normal-tissue volumes. The degree of symptom reduction from conformal radiotherapy will emerge from the RMH randomised trial within the next 12 months.
authors.affiliation: Department of Radiotherapy, Royal Marsden Hospital, Sutton, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Tait
authors.forename: A E
authors.initials: AE
authors.lastname: Nahum
authors.forename: L
authors.initials: L
authors.lastname: Rigby
authors.forename: M
authors.initials: M
authors.lastname: Chow
authors.forename: W P
authors.initials: WP
authors.lastname: Mayles
authors.forename: D P
authors.initials: DP
authors.lastname: Dearnaley
authors.forename: A
authors.initials: A
authors.lastname: Horwich
mesh_terms: D006801:Humans; D007414:Intestinal Neoplasms / Q000532:radiotherapy; D008297:Male; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D010388:Pelvis / Q000528:radiation effects; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D011795:Surveys and Questionnaires; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy