title: The adverse effect of fibrin-clot inhibiting drugs on intravesical bacillus Calmette-Guérin efficacy for superficial bladder cancer.
abstract: Bacillus Calmette-Guérin (BCG) is currently thought to act as a biological immune modifier in effecting antitumour activity. Recent evidence suggests that BCG binding to fibronectin (FN), a tissue glycoprotein, may be a prerequisite step in initiating this response. Drugs inhibiting the availability of exposed FN in the bladder after urothelial disruption may adversely affect the efficacy of BCG. Data are presented of 45 patients with tumour limited to mucosa (pTa) or carcinoma in situ (CIS) given intravesical BCG therapy, with (group 1) or without (group 2) fibrin clot-inhibiting drugs concurrently during treatment. The success rate of 11.1% for group 1 (1/9) patients was significantly less than that of 69.4% for group 2 (25/36), (chi 2 = 7.79, P < 0.01 Fisher's exact test) supporting the suggestion that the concurrent administration of fibrin-clot inhibiting drugs may adversely affect the outcome of BCG therapy.
authors.affiliation: Department of Surgery, University of Queensland, Royal Brisbane Hospital, Australia.
authors.forename: K B
authors.initials: KB
authors.lastname: P'ng
authors.forename: M D
authors.initials: MD
authors.lastname: Walsh
authors.forename: G J
authors.initials: GJ
authors.lastname: Seymour
authors.forename: M F
authors.initials: MF
authors.lastname: Lavin
authors.forename: R A
authors.initials: RA
authors.lastname: Gardiner
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001500:BCG Vaccine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D002278:Carcinoma in Situ / Q000628:therapy*; D005260:Female; D005353:Fibronectins / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000628:therapy*; D014859:Warfarin / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001500:BCG Vaccine; D005353:Fibronectins; D014859:Warfarin; D001241:Aspirin