Detection of simultaneous self-administration of testosterone and epitestosterone in healthy men.
Combined self-administration of testosterone (T) and epitestosterone (ET) by athletes counteracts the efficiency of the corresponding urinary glucuronides (G) ratio, (T/ET)G, as an indicator of T abuse. I therefore propose 5-androstene-3 beta, 17 alpha-diol (5A3 beta 17 alpha), the immediate metabolic precursor of ET, as a new reference compound for the expression of relative excretions of T and ET. Thus (T/5A3 beta 17 alpha)G and (ET/5A3 beta 17 alpha)G become potential criteria to indicate joint administration of T and ET, since their respective threshold values (2.5 and 1.5) are exceeded even when (T/ET)G remains below the critical value of 6.
Dehennin
L
L
Fondation de Recherche en Hormonologie, Fresnes, France.
D000293:Adolescent; D000328:Adult; D004845:Epitestosterone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*; D005188:False Negative Reactions; D005965:Glucuronates / Q000652:urine; D006801:Humans; D008297:Male; D012016:Reference Values; D012651:Self Medication; D013177:Sports; D015813:Substance Abuse Detection; D013739:Testosterone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*
D005965:Glucuronates; D013739:Testosterone; D004845:Epitestosterone