Effects of buspirone on the resistance, development and passive transfer of immunity to Listeria monocytogenes in mice submitted to stress.
Mice exposed to a chronic auditory stressor and treated chronically with buspirone (1 mg/kg) showed a reduction in stress-induced suppression of the resistance and development of immunity to Listeria monocytogenes. Attempts to passively transfer immunity with spleen cells were also performed. Stressed, immunized mice had a reduced capacity to transfer immunity passively to nonimmunized mice and buspirone was found to partially suppress this inhibitory effect of stress.
Freire-Garabal
M
M
Neuroimmunology-University of Santiago (NIMUS), Santiago de Compostela, Spain.
Nuñez
M J
MJ
Fernandez-Rial
J C
JC
Rey-Mendez
M
M
Belmonte
A
A
D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D005260:Female; D007109:Immunity / Q000187:drug effects; D007116:Immunization, Passive; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D008099:Liver / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology / Q000382:microbiology; D013312:Stress, Physiological / Q000276:immunology* / Q000503:physiopathology
D002065:Buspirone