title: Association of baseline neuropsychological function and progression of illness over 4 years in HIV-seropositive individuals.
abstract: The authors conducted a study to examine the association between neuropsychological markers of central nervous system impairment and systemic human immunodeficiency virus (HIV) disease progression in a sample of 64 HIV-positive asymptomatic patients who were followed for a median of 45.6 months. Patients with poorer baseline scores on the Halstead-Reitan Trail-Making A neuropsychological test developed HIV-related systemic symptoms earlier over the study period than patients with the higher scores on the same test (P < 0.05). Subclinical neuropsychological dysfunction in otherwise asymptomatic HIV-infected individuals may be a harbinger of progressive HIV-related immunologic dysfunction.
authors.affiliation: Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
authors.forename: C H
authors.initials: CH
authors.lastname: Silberstein
authors.forename: M A
authors.initials: MA
authors.lastname: O'Dowd
authors.forename: E E
authors.initials: EE
authors.lastname: Schoenbaum
authors.forename: G H
authors.initials: GH
authors.lastname: Friedland
authors.forename: P
authors.initials: P
authors.lastname: Chartock
authors.forename: C
authors.initials: C
authors.lastname: Feiner
authors.forename: F P
authors.initials: FP
authors.lastname: McKegney
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis*; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests