[Possible mechanisms of the emergence of chromosome rearrangements. VI. Mitotic delay as a protective mechanism. Origin of spontaneous chromosome breaks].
It was proved by the investigation of the bone marrow cells and the culture of embryonic fibroblasts of mice, that experimental induction of chromosome breaks having such a distinctive feature as disposition of acentrics outside the equatorial plate at metaphase, results in reduction of the mitotic index and the radiation induced structural mutations frequency. Such disposition of acentrics--outside the equatorial plate--is typical for spontaneous chromosome breaks. It was suggested, that the process resulting in spontaneous chromosome breaks is a component of the protective mechanism, which is put into effect through the mitotic delay.
Lebedeva
L I
LI
Skorova
S V
SV
Akhmamet'eva
E M
EM
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D001920:Bradykinin / Q000494:pharmacology; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D015321:Gene Rearrangement; D006632:Histamine / Q000494:pharmacology; D007399:Interphase / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000235:genetics*; D008940:Mitotic Index; D013997:Time Factors; D014466:Ultraviolet Rays
D006632:Histamine; D001920:Bradykinin
Vozmozhnye mekhanizmy vozniknoveniia perestroek khromosom. VI. Zaderzhka mitoza kak protektornyĭ mekhanizm. Proiskhozhdenie spontannykh razryvov khromosom.