Indium-111-labeled anti-EGFr-425 scintigraphy in the detection of malignant gliomas.
BACKGROUND
The monoclonal antibody anti-epidermal growth factor receptor (EGFr) antibody-425, against the epidermal growth factor receptor, has the potential to bind specifically to gliomas and not normal brain tissue. A prospective study was conducted (1986-1988) to evaluate the use of Indium-111 (111In)-labeled anti-EGFr-425 in the localization of gliomas before radioimmunotherapy with Iodine-125 (125I)-labeled anti-EGFr-425.


METHODS
Twenty-eight patients with intracranial neoplasms were injected intravenously with an average dose of 2.2 mCi 111In-labeled anti-EGFr-425. Planar and single-photon emission computed tomography scans were performed after 48 and 72 hours. Control studies also were performed in two cases with 111In-labeled Co 17-1A (an antibody to colorectal cancer) and in one case with unlabeled 111In chloride.


RESULTS
The immunoscintigraphic findings were generally in good agreement with computerized tomographic findings. The definitive diagnosis was established by biopsy findings: 23 gliomas (1 Grade I, 5 Grade II, 6 Grade III, and 11 Grade IV), 1 meningioma, and 4 metastatic lesions. The localization of gliomas with 111In-labeled anti-EGF-425 had a sensitivity of 0.96, a specificity of 0.60 and an accuracy of 0.90.


CONCLUSIONS
Immunoscintigraphy with 111-In labeled anti-EGFr-425 can be useful in the management of malignant gliomas, especially before radioimmunotherapy with 125I-labeled anti-EGFr-425.
Dadparvar
S
S
Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102-1192.
Krishna
L
L
Miyamoto
C
C
Brady
L W
LW
Brown
S J
SJ
Bender
H
H
Slizofski
W J
WJ
Eshleman
J
J
Chevres
A
A
Woo
D V
DV
D000328:Adult; D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D066246:ErbB Receptors / Q000276:immunology*; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D051379:Mice / Q000276:immunology; D008875:Middle Aged; D016719:Radioimmunodetection
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D066246:ErbB Receptors