Male siblings with schizophrenia share alleles at the androgen receptor above chance expectation.
In families that included two or more siblings with schizophrenia or schizo-affective disorder male-male pairs were found to share alleles at the androgen receptor (AR) gene (in Xq11.2-q12) above chance expectation (p < 0.003); female-female and mixed sex pairs showed no such tendency. The findings are compatible with X-Y linkage or with an X-linked contribution to liability in males.
Crow
T J
TJ
Division of Psychiatry, Clinical Research Centre, Harrow, U.K.
Poulter
M
M
Lofthouse
R
R
Chen
G
G
Shah
T
T
Bass
N
N
Morganti
C
C
Vita
A
A
Smith
C
C
Boccio-Smith
A
A
D000483:Alleles; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011336:Probability; D011944:Receptors, Androgen / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D014960:X Chromosome
D011944:Receptors, Androgen