title: [Neonatal encephalitis caused by herpes simplex: immunohistochemical diagnosis of a case].
abstract: The authors report the case of a female newborn infant, who had seizures and vesicles at the nose and inferior lip since the fifth day of life. CSF changes suggested an encephalitis. Signs of neurologic and respiratory deterioration were followed by death. Partial cranial autopsy showed a necrohemorrhagic temporal encephalitis without intranuclear inclusions. Immunohistochemical examination by the avidin-biotin-peroxidase technique with polyclonal antibodies against Herpes simplex type 1 and type 2 was positive to type 2 Herpes simplex virus.
authors.affiliation: Departamento de Patologia da Fundação Faculdade Federal de Ciências Médicas de Porto Alegre (FFFCMPA), Brasil.
authors.forename: I
authors.initials: I
authors.lastname: Lamego
authors.forename: C
authors.initials: C
authors.lastname: Brinckmann
authors.forename: A
authors.initials: A
authors.lastname: Ciancio
authors.forename: R
authors.initials: R
authors.lastname: Minotto
authors.forename: A
authors.initials: A
authors.lastname: Hilbig
authors.forename: J M
authors.initials: JM
authors.lastname: Ulbrich-Kulczynski
authors.forename: M H
authors.initials: MH
authors.lastname: Fontana
authors.forename: L M
authors.initials: LM
authors.lastname: Barbosa-Coutinho
mesh_terms: D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000209:etiology / Q000473:pathology*; D005260:Female; D006561:Herpes Simplex / Q000134:cerebrospinal fluid / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn
vernacular_title: Encefalite neo-natal pelo vírus do herpes simplex: diagnóstico imuno-histoquímico de um caso.