title: Effect of benzo[a]phenothiazines on natural killer cell activity of human peripheral blood mononuclear cells.
abstract: Four benzo[a]phenothiazines were investigated for their effects on antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell and blast transformation of human peripheral blood mononuclear cells (PBM). Benzo[a]phenothiazines dose-dependently suppressed the nitrogen-stimulated T cell proliferation. The suppressive effect of non differentiation-inducing benzo[a]phenothiazines was higher than that of differentiation-inducing benzo[a]phenothiazines. The stimulation effect of differentiation-inducing compounds on the NK activity was reduced by removal of monocytes from the PBM. The results suggest the direct activation of monocytes (Mo) by differentiation-inducing benzo[a]phenothiazines.
authors.affiliation: Blood Transfusion Centre, Szeged, Hungary.
authors.forename: I B
authors.initials: IB
authors.lastname: Petri
authors.forename: E
authors.initials: E
authors.lastname: Szekeres
authors.forename: I
authors.initials: I
authors.lastname: Berek
authors.forename: J
authors.initials: J
authors.lastname: Molnár
authors.forename: H
authors.initials: H
authors.lastname: Sakagami
authors.forename: N
authors.initials: N
authors.lastname: Motohashi
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D010640:Phenothiazines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D010640:Phenothiazines; D004247:DNA