title: [Planning of samples for linkage analysis. Incomplete penetrance].
abstract: Dependence of the minimal size of a pedigree sample providing the given quality of a linkage decision on the genotype penetrance of the localized gene is considered. The two ways of the sample informativity increase are discussed and their effects are estimated. These ways are: the adequate choice of a marker gene and certain complication of a pedigree structure. It is shown for the latter that the effect can be achieved only for certain phenotypic characteristics of the additional pedigree members.
authors.forename: T I
authors.initials: TI
authors.lastname: Aksenovich
authors.forename: E Kh
authors.initials: EKh
authors.lastname: Ginzburg
mesh_terms: D002874:Chromosome Mapping; D008040:Genetic Linkage; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D010375:Pedigree; D012494:Sampling Studies
vernacular_title: O planirovanii vyborki dlia analiza stsepleniia. Proizvol'naia penetrantnost'.