title: Chlorambucil-associated pneumonitis.
abstract: A patient developed an interstitial pneumonitis while receiving chlorambucil for a chronic lymphocytic leukemia (cumulative dose, 8,340 mg). Withdrawal of drug treatment was followed by rapid improvement in the clinical condition. Bronchoalveolar lavage showed a T-lymphocytic alveolitis, whereas blood lymphocytes were predominantly of the B phenotype. The T-lymphocytic alveolitis persisted 6 weeks after drug therapy cessation with a predominant CD8+ phenotype, as observed in some hypersensitivity pneumonitis induced by drugs.
authors.affiliation: Immuno-Hematology Unit, Hôpital Saint Louis, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Crestani
authors.forename: A
authors.initials: A
authors.lastname: Jaccard
authors.forename: D
authors.initials: D
authors.lastname: Israël-Biet
authors.forename: L J
authors.initials: LJ
authors.lastname: Couderc
authors.forename: J
authors.initials: J
authors.lastname: Frija
authors.forename: J P
authors.initials: JP
authors.lastname: Clauvel
mesh_terms: D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002699:Chlorambucil / Q000009:adverse effects*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000473:pathology; D008218:Lymphocytosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology
chemical_list: D002699:Chlorambucil