title: [Sequences resembling fragments of mitochondrial DNA in the human genome: features of evolution].
abstract: Mitochondrial-like sequences and their homologues from primate mitochondria are investigated to define direction and rate of evolution, time of integration into nuclear genome. The analysis showed that mito-like sequences differ from mitochondrial homologues by high level of symmetria of two chains of DNA. Besides that, difference between mito-like and Homo sapiens sequences in their GC-contents is found. Apparently there is GC-pressure of nuclear genome region, being the place of integration of mito-like sequence, that brings about equalization of GC-contents in nuclear region and mito-like sequences. Properties of descent mitochondrial sequence play important role in the difference of mito-like and Homo sapiens sequences also.
authors.forename: T L
authors.initials: TL
authors.lastname: Sitnikova
authors.forename: A A
authors.initials: AA
authors.lastname: Zharkikh
mesh_terms: D001482:Base Composition; D005075:Biological Evolution; D003596:Cytosine / Q000032:analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D015894:Genome, Human; D006147:Guanine / Q000032:analysis; D006801:Humans; D012343:RNA, Transfer; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004272:DNA, Mitochondrial; D006147:Guanine; D003596:Cytosine; D012343:RNA, Transfer
vernacular_title: Posledovatel'nosti, podobnye fragmentam mitokhondrial'noĭ DNK, v genome cheloveka: osobennosti évoliutsii.