title: Amlodipine in mild and moderate hypertension: initial Indian experience.
abstract: In an open, non-comparative, variable-dose study, 20 outpatients with mild to moderate essential hypertension were treated with 5-10 mg amlodipine once daily for 4 weeks, after their blood pressures had stabilized on placebo. Amlodipine produced a significant decrease in blood pressure (P < 0.05) from the initial mean of 162/100 mm Hg to 139/85 mm Hg at 4 weeks. 80% of the patients reached the goal diastolic blood pressure of < or = 90 mm Hg with a once-daily dose of 5 mg amlodipine within 2 weeks. The remaining 20% also attained the goal diastolic blood pressure within 4 weeks, with a one-step increase in the dose to 10 mg at 2 weeks. Amlodipine maintained blood pressure reduction throughout the 24-hours dosing interval with a once-daily dose. Notably, no side effects were observed; pulse rate, electrocardiogram, and laboratory parameters were not significantly altered with therapy. Amlodipine in a single daily dose of 5-10 mg is effective and well tolerated in the treatment of patients with mild to moderate hypertension.
authors.affiliation: Medical Research Division, Pfizer Ltd., Bombay.
authors.forename: R C
authors.initials: RC
authors.lastname: Khokhani
authors.forename: P
authors.initials: P
authors.lastname: Chopra
authors.forename: N D
authors.initials: ND
authors.lastname: Karnik
authors.forename: K D
authors.initials: KD
authors.lastname: Bajan
authors.forename: R
authors.initials: R
authors.lastname: Ailiani
authors.forename: S S
authors.initials: SS
authors.lastname: Waknis
authors.forename: T A
authors.initials: TA
authors.lastname: Joseph
authors.forename: K P
authors.initials: KP
authors.lastname: Chawla
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method
chemical_list: D017311:Amlodipine