Biochemical and physiological aspects in the dimorphism of Paracoccidioides brasiliensis.
Paracoccidioides brasiliensis is a dimorphic fungus pathogenic for humans. It shows a yeast like phase at 37 degrees C and a mycelial phase at 23 degrees C. Biochemical aspects of its dimorphism are related to the presence of hormone receptors, regulation of cAMP, or modulation of glucan synthetase activity through cytoplasmic proteinases. These aspects are reviewed herein.
San-Blas
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Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Microbiología y Biología Celular, Caracas.
D002473:Cell Wall / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D004198:Disease Susceptibility; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005936:Glucans / Q000096:biosynthesis; D006801:Humans; D008297:Male; D009024:Morphogenesis / Q000187:drug effects; D010228:Paracoccidioides / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D010229:Paracoccidioidomycosis / Q000503:physiopathology; D015290:Second Messenger Systems / Q000502:physiology
D005656:Fungal Proteins; D005936:Glucans; D004958:Estradiol; D000242:Cyclic AMP