title: Two new modified trichothecenes from Fusarium sporotrichioides.
abstract: Two new modified trichothecenes, 2-deoxy-11-epi-3 alpha-hydroxysambucoin [1] and 2-deoxy-11-epi-12-acetyl-3 alpha-hydroxysambucoin [2], were isolated from Fusarium sporotrichioides culture. This is the first report of modified trichothecenes where the two six-membered rings are cis-fused. Structures were elucidated using gc-ms, nmr, X-ray crystallography, and other spectroscopic techniques. Compounds 1 and 2 were screened for relative cytotoxicity in cultured baby hamster kidney (BHK-21) cells and found to be non-toxic.
authors.affiliation: Department of Chemistry, University of Missouri, Columbia 65211.
authors.forename: D M
authors.initials: DM
authors.lastname: Fort
authors.forename: C L
authors.initials: CL
authors.lastname: Barnes
authors.forename: M S
authors.initials: MS
authors.lastname: Tempesta
authors.forename: H H
authors.initials: HH
authors.lastname: Casper
authors.forename: E
authors.initials: E
authors.lastname: Bekele
authors.forename: A A
authors.initials: AA
authors.lastname: Rottinghaus
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000302:isolation & purification / Q000633:toxicity; D005670:Fusarium / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007668:Kidney / Q000166:cytology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D014255:Trichothecenes / Q000302:isolation & purification* / Q000633:toxicity; D014908:Triticum / Q000382:microbiology
chemical_list: D003603:Cytotoxins; D014255:Trichothecenes