title: The effects of a silica dentifrice containing Triclosan and zinc citrate on supragingival plaque and calculus formation and the control of gingivitis.
abstract: A double blind, 7-month parallel clinical study was conducted to determine the effect of a dentifrice containing 0.3 per cent Triclosan and 0.75 per cent zinc citrate in a 0.8 per cent sodium monofluorophosphate/silica base on supragingival plaque, gingivitis and supragingival calculus formation, compared to a 0.8 per cent monofluorophosphate/silica control dentifrice. The results of this clinical study demonstrate that the use of the Triclosan/zinc citrate dentifrice over a 7-month period provided a statistically significant and clinically relevant benefit in controlling gingivitis, compared to a control dentifrice. Supragingival plaque and calculus levels were also significantly reduced in comparison to the effects of a control dentifrice.
authors.affiliation: Unilever Dental Research, Bebington, Wirral.
authors.forename: B
authors.initials: B
authors.lastname: Svatun
authors.forename: C A
authors.initials: CA
authors.lastname: Saxton
authors.forename: E
authors.initials: E
authors.lastname: Huntington
authors.forename: D
authors.initials: D
authors.lastname: Cummins
mesh_terms: D000328:Adult; D002951:Citrates / Q000008:administration & dosage / Q000627:therapeutic use*; D019343:Citric Acid; D003728:Dental Calculus / Q000517:prevention & control*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009910:Oral Hygiene; D010512:Periodontal Index; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use; D012822:Silicon Dioxide; D013997:Time Factors; D014099:Toothbrushing; D014260:Triclosan / Q000008:administration & dosage / Q000627:therapeutic use*; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002951:Citrates; D003802:Dentifrices; D010710:Phosphates; C012980:fluorophosphate; D019343:Citric Acid; D014260:Triclosan; D012822:Silicon Dioxide; D015032:Zinc; D005459:Fluorides