Effect of prednisolone on renal scarring in rats following infection with Serratia marcescens.
Renal scarring is considered a criterion of reflux nephropathy and the end stage of pyelonephritis. Prednisolone, a strong anti-inflammatory drug, at doses of 1 or 2 mg/kg prevented renal scarring in rats following infection with Serratia marcescens. Four or 8 mg/kg of prednisolone, however, did not inhibit renal scar formation. In a time course experiment, renal scarring was prevented when 4-day treatment with prednisolone was initiated 2, 5, or 13 days after infection. These results show that prednisolone is effective in preventing such scarring and suggest the clinical use of this drug for preventing renal scar formation after pyelonephritis and reflux nephropathy.
Haraoka
M
M
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Matsumoto
T
T
Mizunoe
Y
Y
Ogata
N
N
Takahashi
K
K
Kubo
S
S
Tanaka
M
M
Kumazawa
J
J
D000818:Animals; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000382:microbiology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011704:Pyelonephritis / Q000188:drug therapy* / Q000382:microbiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016868:Serratia Infections / Q000188:drug therapy*; D012706:Serratia marcescens
D011239:Prednisolone