title: Chronology of combined chemotherapy (5FU) and radiotherapy. I. In vitro study.
abstract: Since radiotherapy or chemotherapy alone may be ineffective, they are more and more often combined. In this in vitro studies the effects of the chronology of the treatments and of the time interval between them are evaluated. In murine leukaemia L1210 cells and in murine mammary adenocarcinoma Ca755 cells the highest efficacy, i.e. the lowest survival fraction, was observed when radiotherapy was administered 6 h before Fluorouracil (FU). To mimic treatment in man, a daily combined treatment was also tested. Under these circumstances, the chronology of the treatments and the time interval between them had different consequences, the highest efficacy being noticed when both treatments were given at the same time.
authors.affiliation: Laboratoire de Pharmacologie, Institut Jean-Godinot, Reims, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Carpentier
authors.forename: L
authors.initials: L
authors.lastname: Demange
authors.forename: M
authors.initials: M
authors.lastname: Loirette
authors.forename: J
authors.initials: J
authors.lastname: Hivet
authors.forename: B
authors.initials: B
authors.lastname: Desoize
mesh_terms: D000230:Adenocarcinoma; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects*; D003131:Combined Modality Therapy / Q000379:methods; D005472:Fluorouracil / Q000633:toxicity*; D006801:Humans; D007939:Leukemia L1210; D008325:Mammary Neoplasms, Experimental; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D005472:Fluorouracil