title: Dorsal root ganglion proteins in Friedreich's ataxia.
abstract: The polypeptide composition of dorsal root ganglia from 8 human controls, 6 Friedreich's ataxia (FA) patients and 1 patient with diabetic neuropathy was studied by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis (PAGE). Silver-stained gels demonstrated a decrease in a 40-kDa protein in FA patients. This protein appeared to be present in normal amounts in the diabetic ganglion, suggesting that this 40-kDa protein deficiency was not simply a reflection of reduced neuronal numbers but may be specific for FA.
authors.affiliation: Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Small
authors.forename: P K
authors.initials: PK
authors.lastname: Thomas
authors.forename: A H
authors.initials: AH
authors.lastname: Schapira
mesh_terms: D003929:Diabetic Neuropathies / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005621:Friedreich Ataxia / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000302:isolation & purification; D012016:Reference Values
chemical_list: D009419:Nerve Tissue Proteins