Tocopherols and carotenes are differently distributed in subfractions of high-density lipoprotein.
An apolipoprotein (apo) E-rich and an apo E-poor fraction of high-density lipoprotein (HDL) were isolated from four healthy men by heparin-Sepharose affinity chromatography. On a cholesterol basis, the apo E-poor HDL fraction contained a third more alpha- and gamma-tocopherol and about a third less alpha- and beta-carotene than the apo E-rich HDL fraction. Plasma concentrations of HDL cholesterol were highly correlated with the contribution of the apo E-rich HDL subfraction to total HDL alpha-tocopherol (r = -0.990, P < 0.001).
Brown
A J
AJ
Cardiovascular Research Unit, University of Edinburgh, Scotland, UK.
Fragoso
Y D
YD
D001057:Apolipoproteins E / Q000737:chemistry*; D002338:Carotenoids / Q000032:analysis*; D008076:Cholesterol, HDL / Q000097:blood; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D014810:Vitamin E / Q000032:analysis*
D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014810:Vitamin E; D002338:Carotenoids