title: [Effect of Mycobacterium tuberculosis on activity of lysosomal enzymes in mouse peritoneal macrophages].
abstract: The studies of the effects produced by M. tuberculosis various strains on the activity of lysosomal enzymes in peritoneal mouse macrophages demonstrated multidirectional influence of the bacilli. Non-sedimentary activity rose in matrical enzymes indicating lysosomal membranes instability due to M. tuberculosis infection followed by hydrolase activation and hydrolases escape into the cytosol. An inhibiting action of pathogenic mycobacteria on lysosomal proteases is suggested.
authors.forename: V A
authors.initials: VA
authors.lastname: Sozinov
authors.forename: I P
authors.initials: IP
authors.lastname: Metelitsina
authors.forename: E K
authors.initials: EK
authors.lastname: Plotnikova
authors.forename: A I
authors.initials: AI
authors.lastname: Sinitsa
authors.forename: M I
authors.initials: MI
authors.lastname: Borisova
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D002402:Cathepsin D / Q000032:analysis; D020059:Cathepsin E; D002403:Cathepsins / Q000032:analysis; D004789:Enzyme Activation; D008247:Lysosomes / Q000201:enzymology*; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000201:enzymology*; D008297:Male; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000502:physiology*; D014376:Tuberculosis / Q000201:enzymology*; D001616:beta-Galactosidase / Q000032:analysis; D001617:beta-Glucosidase / Q000032:analysis
chemical_list: D000135:Acid Phosphatase; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D002403:Cathepsins; D020059:Cathepsin E; D002402:Cathepsin D
vernacular_title: Vliianie mikobakteriĭ tuberkulëza na aktivnost lizosomalńykh fermentov peritonealńykh makrofagov mysheĭ.