Effects of a biologically active LHRH fragment on CA1 hippocampal neurons.
The actions of a behaviorally active luteinizing hormone-releasing hormone fragment, Ac-LHRH(5-10), on CA1 pyramidal cells were studied utilizing conventional intracellular recordings from the in vitro rat hippocampal slice preparation. The behaviorally active fragment (10(-7) M) and the natural decapeptide [LHRH(1-10), 10(-8) M] had similar actions on CA1 neurons: a long-duration depolarization associated with increased input resistance, a reduction in the slow afterhyperpolarization (AHP), and a decrease in accommodation. In contrast, a biologically inactive LHRH fragment [LHRH(1-6) at 10(-7) M] had no effect on electrical properties of CA1 neurons. These data suggest that Ac-LHRH(5-10), like LHRH(1-10), may have a modulatory action on hippocampal neurons.
Chen
Y
Y
Department of Physiology, University of Texas Southwestern Medical Center at Dallas 75235-9040.
Wong
M
M
Moss
R L
RL
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
C085273:LHRH (1-10); D010446:Peptide Fragments; D007987:Gonadotropin-Releasing Hormone; C085272:LHRH (1-6); C038418:LHRH(5-10), Ac-