title: Protective effect of dantrolene sodium on carbon tetrachloride induced liver injury in the rat.
abstract: The effect of dantrolene sodium on liver injury induced by CCl4 was investigated in the rat. Liver microsomal P-450 and b5 levels, serum triiodothyronine levels (T3), and alanine aminotransferase activity (ALT) were measured over 4 to 16 h after CCl4 (0.2 ml/kg, s.c.) administration. Serum ALT rose following CCl4 administration, while liver cytochrome P-450 and b5 levels and serum T3 which reflects the liver microsomal thyroxine-5'-deiodinase activity (1) fell. Intraperitoneal administration of dantrolene sodium (5 mg/kg), 1 h before CCl4 s.c., suppressed CCl4-induced elevation of the serum ALT significantly. However, levels of P-450, b5, and serum T3 were not significantly different between dantrolene-treated and untreated groups. These results suggest that dantrolene sodium has a protective effect on CCl4-induced liver injury through a mechanism unrelated to these liver microsomal functions.
authors.affiliation: Third Department of Internal Medicine, Saitama Medical School, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yamagishi
authors.forename: T
authors.initials: T
authors.lastname: Komoda
authors.forename: K
authors.initials: K
authors.lastname: Ohnishi
authors.forename: S
authors.initials: S
authors.lastname: Itoh
mesh_terms: D000410:Alanine Transaminase / Q000187:drug effects; D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D015786:Cytochromes b5 / Q000187:drug effects; D003620:Dantrolene / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014284:Triiodothyronine / Q000187:drug effects
chemical_list: D014284:Triiodothyronine; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase; D003620:Dantrolene