[Ultramicroscopic aspects of the lungs in copper-deficient newborn rats].
In order to investigate the possible morphological alterations in the lungs of copper-deficient neonatal rats, three groups of 10 female Sprague-Dawley rats were used. The copper-deficient group was fed with a copper-free diet beginning at 35 days before pregnancy and throughout the gestation period. The control group received a diet adequate in copper and the pair-fed group received a diet with adequate copper content, but in limited amounts. After birth, the ultrastructural study of the neonatal lungs showed a thickening of the air-blood barrier in the copper-deficient group. No other differences were observed in the rest of the pulmonary structures.
Sarricolea Erausquin
M L
ML
Unidad de Investigación Pediátrica, Universidad de Navarra, Pamplona.
Villa-Elízaga
I
I
López del Corral
J
J
D000818:Animals; D000831:Animals, Newborn; D003300:Copper / Q000172:deficiency*; D005260:Female; D008168:Lung / Q000648:ultrastructure*; D008854:Microscopy, Electron; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D003300:Copper
Aspectos ultramicroscópicos en pulmón de neonatos de rata cuprodeficiente.