title: Little evidence for anti-endothelial-cell antibodies in microscopic polyarteritis and Wegener's granulomatosis.
abstract: Sera from patients with a vasculitis and controls were investigated for the presence of anti-endothelial cell antibodies(AECA), anti- neutrophil cytoplasmic antibodies(ANCA) and anti-myeloperoxidase (MPO) antibodies. Only 19% of patients with Wegener's granulomatosis and 2% of patients with microscopic polyarteritis had AECA. Our data suggests that AECA are a minor antibody system in vasculitis.
authors.affiliation: Renal Research Laboratory, Queen Elizabeth Hospital, Edgbaston, Birmingham.
authors.forename: M
authors.initials: M
authors.lastname: Varagunam
authors.forename: A C
authors.initials: AC
authors.lastname: Nwosu
authors.forename: D
authors.initials: D
authors.lastname: Adu
authors.forename: C
authors.initials: C
authors.lastname: Garner
authors.forename: C M
authors.initials: CM
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Michael
authors.forename: R A
authors.initials: RA
authors.lastname: Thompson
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001167:Arteritis / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D009195:Peroxidase / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009195:Peroxidase