title: Platelets in essential hypertension.
abstract: The ultrastructure and adenosine diphosphate induced aggregatory response of platelets of 39 patients with essential hypertension have been studied. Both, transmission and scanning electron microscopy showed the co-existence of various morphological forms of platelets suggestive of activation. The hypertensive platelets also exhibited increased sensitivity to ADP induced aggregation confirming the activated state of platelets; the degree of activation correlated well with the levels of diastolic blood pressure.
authors.affiliation: Department of Medicine, King George's Medical College, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Nityanand
authors.forename: I
authors.initials: I
authors.lastname: Pande
authors.forename: V K
authors.initials: VK
authors.lastname: Bajpai
authors.forename: L
authors.initials: L
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: Chandra
authors.forename: B N
authors.initials: BN
authors.lastname: Singh
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D015539:Platelet Activation / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D011554:Pseudopodia / Q000648:ultrastructure
chemical_list: D000244:Adenosine Diphosphate