Interaction between beta-blockers and contrast media during intracoronary administration in rabbit heart.
The effects of ionic, meglumine sodium diatrizoate (Urografin 76) and nonionic, iohexol contrast media were examined in the absence and presence of propranolol, a beta-blocker having nonspecific membrane stabilizing action and atenolol, a beta-blocker lacking nonspecific membrane stabilizing action on Langendorff-perfused rabbit hearts. Contrast medium, 0.7 ml, was injected into the aortic root in the absence and presence of 10(-7) and 10(-5) M beta-blocker to observe the changes in resting tension, force of contraction, rate of contraction, heart rate and PR interval. Beta-blockers and contrast media interact in affecting myocardial contractility, heart rate and atrioventricular conduction. The interaction is milder when the beta-blocker lacks membrane stabilizing activity and the contrast medium is nonionic.
Salbaş
K
K
Department of Cardiology, Media School of Ankara University, Turkey.
Akgün
G
G
Pamĭr
G
G
Gürel
T
T
D000818:Animals; D001262:Atenolol / Q000008:administration & dosage / Q000494:pharmacology*; D001283:Atrioventricular Node / Q000187:drug effects; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects*; D006327:Heart Block / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D007267:Injections; D007472:Iohexol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
D003974:Diatrizoate Meglumine; D007472:Iohexol; D001262:Atenolol; D011433:Propranolol