Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents.
Boyle
F T
FT
ZENECA Pharmaceuticals, Macclesfield, Cheshire, UK.
Matusiak
Z S
ZS
Hughes
L R
LR
Slater
A M
AM
Stephens
T C
TC
Smith
M N
MN
Brown
M
M
Kimbell
R
R
Jackman
A L
AL
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000201:enzymology; D051379:Mice; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011799:Quinazolines; D005492:Folic Acid; D013940:Thymidylate Synthase; C059966:ICI 198583