[Cerebral sinus thrombosis in a young man with hereditary protein C deficiency].
A 23-year-old man was admitted because of vomiting and severe, progressive headache. After admission, he suffered from a generalized clonic seizure, and developed right hemiparesis. Contrast-enhanced CT of the brain showed empty delta sign in the posterior part of the superior sagittal sinus and filling defect in the straight sinus. T2-weighted MRI demonstrated high intensity area in the left parieto-occipital subcortical region. Delayed venous phase of the right carotid angiography confirmed the diagnosis of thrombosis of the superior sagittal sinus. Coagulation studies gave a protein C activity of 35.3% (normal range 55-140%), protein C antigen of 45% (normal range 70-150%). Same results were obtained from the studies of his father and one of his sisters, indicating hereditary protein C deficiency. We started warfarin therapy under the administration of heparin for a week, then he has been followed up with no subsequent problems.
Shimazaki
H
H
Department of Neurology, Jichi Medical School.
Ogawa
M
M
Takiyama
Y
Y
Nishizawa
M
M
Yoshida
M
M
D000328:Adult; D006801:Humans; D008297:Male; D020151:Protein C Deficiency; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin