[Genetic heterogeneity of certain sporadic colorectal cancers].
Intratumoral heterogeneity provides information concerning the timing of genetic events which occur during colorectal carcinogenesis. In a series of 14 colorectal adenocarcinomas, the following genetic alterations were characterized: loss of heterozygosity on chromosomes 17 p, 1 p, 18 q, 5 q and 22 q, point mutations on TP53 and K-RAS genes, change in DNA index. Six of the 14 initial samples were investigated for putative genetic heterogeneity. In two cases, variations in genetic alterations on chromosome 17 p and gene TP53 were demonstrated. These events seem to occur at a late stage in colorectal carcinogenesis.
Vincent-Salomon
A
A
Laboratoire de Génétique des Tumeurs, Institut Curie, Paris.
Olschwang
S
S
Hamelin
R
R
Remvikos
Y
Y
Laurent-Puig
P
P
Thomas
G
G
D000230:Adenocarcinoma / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D003110:Colonic Neoplasms / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005434:Flow Cytometry; D052138:Genes, Neoplasm / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction; D012004:Rectal Neoplasms / Q000235:genetics*
Hétérogénéité génétique de certains cancers colorectaux sporadiques.