title: Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy.
abstract: Tomotherapy, literally "slice therapy," is a proposal for the delivery of radiation therapy with intensity-modulated strips of radiation. The proposed method employs a linear accelerator, or another radiation-emitting device, which would be mounted on a ring gantry like a CT scanner. The patient would move through the bore of the gantry simultaneously with gantry rotation. The intensity modulation would be performed by temporally modulated multiple independent leaves that open and close across the slit opening. At any given time, any leaf would be (1) closed, covering a portion of the slit, (2) open, allowing radiation through, or (3) changing between these states. This method would result in the delivery of highly conformal radiation. Overall treatment times should be comparable with contemporary treatment delivery times. The ring gantry would make it convenient to mount a narrow multisegmented megavoltage detector system for beam verification and a CT scanner on the treatment unit. Such a treatment unit could become a powerful tool for treatment planning, conformal treatment, and verification using tomographic images. The physical properties of this treatment delivery are evaluated and the fundamental design specifications are justified.
authors.affiliation: Department of Medical Physics and Human Oncology, University of Wisconsin, Madison.
authors.forename: T R
authors.initials: TR
authors.lastname: Mackie
authors.forename: T
authors.initials: T
authors.lastname: Holmes
authors.forename: S
authors.initials: S
authors.lastname: Swerdloff
authors.forename: P
authors.initials: P
authors.lastname: Reckwerdt
authors.forename: J O
authors.initials: JO
authors.lastname: Deasy
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: B
authors.initials: B
authors.lastname: Paliwal
authors.forename: T
authors.initials: T
authors.lastname: Kinsella
mesh_terms: D006801:Humans; D008433:Mathematics; D008962:Models, Theoretical; D011878:Radiotherapy / Q000295:instrumentation* / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods