title: Prevalence of anti-cardiolipin antibody in habitual aborters.
abstract: An enzyme-linked immunosorbent assay was developed for the detection of anticardiolipin antibody (ACA) in habitual aborters. Results above the 98th percentile of a distribution of 100 blood donors were considered to be positive. Specific binding index for ACA was higher in 20 patients with at least 3 consecutive spontaneous abortions (group A) than in 20 women with at least one live birth without pregnancy wastage (group B). ACA was detected in 4 patients of group A and in none of the women of group B. Most of the pregnancy wastages occurred after the first trimester in ACA-positive patients and during the first trimester in ACA-negative patients.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital, Faculty of Medicine of Ribeirão Preto, SP, Brazil.
authors.forename: H de L
authors.initials: Hde L
authors.lastname: Costa
authors.forename: M D
authors.initials: MD
authors.lastname: de Moura
authors.forename: R A
authors.initials: RA
authors.lastname: Ferriani
authors.forename: M I
authors.initials: MI
authors.lastname: Anceschi
authors.forename: J E
authors.initials: JE
authors.lastname: Barbosa
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D008297:Male; D011247:Pregnancy; D012016:Reference Values
chemical_list: D017153:Antibodies, Anticardiolipin