title: High-dose tocopherol acetate therapy in epidermolysis bullosa siblings of the Cockayne-Touraine type.
abstract: We have employed a successful therapy for epidermolysis bullosa with high-dose oral tocopherol acetate. Two siblings with dominant dystrophic epidermolysis bullosa of the Cockayne-Touraine type were reported. Both siblings suffered from tense blisters and erosions healing with scars and transient milia on the extremities. Electron microscopic study of the blisters revealed a cleavage beneath the lamina densa in both siblings. High-dose oral tocopherol acetate therapy was administered to them with satisfactory clinical reduction of the blister formation.
authors.affiliation: Department of Dermatology, University of Ehime School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shirakata
authors.forename: S
authors.initials: S
authors.lastname: Shiraishi
authors.forename: K
authors.initials: K
authors.lastname: Sayama
authors.forename: H
authors.initials: H
authors.lastname: Shinmori
authors.forename: Y
authors.initials: Y
authors.lastname: Miki
mesh_terms: D016108:Epidermolysis Bullosa Dystrophica / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols