Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization.
Phosducin is a soluble photoreceptor phosphoprotein that probably modulates phototransduction in the retina and thus qualifies as a potential candidate gene for retinitis pigmentosa. Using both human/mouse somatic cell hybrids and in situ hybridization to human metaphase chromosomes, we have mapped this gene to chromosome 1q25-1q32.1.
Sparkes
R S
RS
Department of Medicine, Jules Stein Eye Institute, UCLA Center for the Health Sciences 90024.
Lee
R H
RH
Shinohara
T
T
Craft
C M
CM
Kojis
T
T
Klisak
I
I
Heinzmann
C
C
Bateman
J B
JB
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005136:Eye Proteins / Q000235:genetics*; D020555:GTP-Binding Protein Regulators; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D051379:Mice; D010750:Phosphoproteins / Q000235:genetics*
D005136:Eye Proteins; D020555:GTP-Binding Protein Regulators; D010750:Phosphoproteins; C065631:phosducin