Modulation of beta 2-adrenoceptors in lymphocytes of allergic patients after in vitro antigenic stimulation.
In this study, we assessed the effect of antigen-specific stimulation on beta-adrenoceptors of human lymphocytes in order to study the beta-receptor atopy theory of Szentivanyi. Determination of these receptors was basically carried out as described by Brodde et al., utilizing [125I]-cyanopindolol as ligand in control and allergic patients before and after stimulation with specific antigen. We found that in vitro the specific antigen-antibody reaction induces a decrease in beta-adrenoceptors. This alteration takes place in patients with rhinitis and asthma with sensitization to Dermatophagoides and grass pollen, regardless of their baseline clinical status. Therefore, in view of the results, we question the validity of Szentivanyi's atopy theory. We hypothesize that the modification in the beta-adrenoceptor system is a consequence rather than the cause of the activity of atopic diseases.
de la Cuesta
C G
CG
Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Pamplona, Spain.
Sanz
M L
ML
Gamboa
P M
PM
Diéguez
I
I
Oehling
A
A
D000328:Adult; D000941:Antigens / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D008297:Male; D018343:Receptors, Adrenergic, beta-2 / Q000032:analysis*
D000941:Antigens; D018343:Receptors, Adrenergic, beta-2