Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties.
Meyer
D J
DJ
Department of Biochemistry and Molecular Biology, University College and Middlesex School of Medicine, London, England.
Coles
B
B
Harris
J
J
Gilmore
K S
KS
Raney
K
K
Harris
T M
TM
Guengerich
F P
FP
Kensler
T W
TW
Ketterer
B
B
D016604:Aflatoxin B1 / Q000031:analogs & derivatives / Q000378:metabolism; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D003600:Cytosol / Q000201:enzymology; D004790:Enzyme Induction; D005982:Glutathione Transferase / Q000096:biosynthesis* / Q000302:isolation & purification; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D046911:Macromolecular Substances; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013871:Thiones / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D046911:Macromolecular Substances; D013871:Thiones; D013876:Thiophenes; D016604:Aflatoxin B1; D005982:Glutathione Transferase; C049325:1,2-dithiol-3-thione; D010634:Phenobarbital