[Ceftriaxone in malignant occlusive jaundice. Studies of serum and bile concentration in disordered bile excretion].
METHODS
In 12 patients with inoperable malignant obstructive jaundice, percutaneous transhepatic biliary drainage was performed to decompensate the bile ducts. For a period of 7 days, the patients received a single daily i.v. dose of 1 g CFTX, and the serum and bile concentrations were measured at defined intervals.


RESULTS
The dose sufficed to kill about 85% of the expected organisms. Although an accumulation of the substance as documented under conditions of normal bile flow was not demonstrable under cholestatic conditions, effective levels were nevertheless found in the bile and showed a tendency to increase with increasing bile flow.
Maikowski
C
C
Medizinische Klinik, Stiftung Hospital zum Heiligen Geist, Frankfurt/M.
Rösch
W
W
Sörgel
F
F
D000368:Aged; D000369:Aged, 80 and over; D001646:Bile / Q000378:metabolism*; D001661:Biliary Tract Neoplasms / Q000097:blood* / Q000188:drug therapy; D001663:Bilirubin / Q000097:blood; D002443:Ceftriaxone / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002761:Cholangitis / Q000097:blood* / Q000188:drug therapy; D001651:Cholestasis, Extrahepatic / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
D002443:Ceftriaxone; D001663:Bilirubin
Ceftriaxon beim malignen Verschlussikterus. Untersuchungen zur Serum- und Gallenkonzentration bei gestörter Gallenausscheidung.