title: ANCA in systemic vasculitides, collagen vascular diseases, rheumatic disorders and inflammatory bowel diseases.
abstract: It was the aim of this study to reevaluate the diagnostic significance and clinical implication of ANCA after testing sera from 13,606 patients for the presence of ANCA. Our data confirm the high specificity (97%) and sensitivity (80%) of cANCA for Wegener's granulomatosis. pANCA were found in renal vasculitides (60%), collagen vascular diseases (SLE 20%, Sjögren's syndrome 26%, polymyositis 16%) and rheumatic disorders (Felty's syndrome 50%, rheumatoid arthritis 20%). A third fluorescence pattern in sera of patients with inflammatory bowel disease (ulcerative colitis 28/72, Crohn's disease 6/84), here called xANCA, was seen. Target antigens of granule proteins from PMN and monocytes (proteinase 3, myeloperoxidase, elastase, cathepsin G, lactoferrin, lysozyme) were identified.
authors.affiliation: Dept. of Rheumatology, Medical University of Lübeck, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Hauschild
authors.forename: W H
authors.initials: WH
authors.lastname: Schmitt
authors.forename: E
authors.initials: E
authors.lastname: Csernok
authors.forename: B K
authors.initials: BK
authors.lastname: Flesch
authors.forename: A
authors.initials: A
authors.lastname: Rautmann
authors.forename: W L
authors.initials: WL
authors.lastname: Gross
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D003095:Collagen Diseases / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D053146:Myeloblastin; D009195:Peroxidase / Q000276:immunology; D012216:Rheumatic Diseases / Q000276:immunology*; D012697:Serine Endopeptidases / Q000276:immunology; D014657:Vasculitis / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin