Aqueous extracts of garlic (Allium sativum) inhibit prostaglandin synthesis in the ovine ureter.
The prostaglandins (PGs) synthesized from C14-arachidonic acid by the homogenized sheep ureter were identified as being prostacyclin (PGI2), PGF2 alpha and thromboxane B2 (TXB2). The radioimmunoassay (RIA) estimation of 6-keto-PGF1 alpha, a stable metabolite of PGI2, confirms that it was the major metabolite of arachidonic acid. Aqueous extracts of fresh garlic (5, 12.5, 25 and 50 mg/ml) were shown to inhibit the synthesis of the prostanoids in a dose dependent manner. Fresh garlic extracts (1, 2.5, 5 and 10 mg/ml) also dose dependently inhibited spontaneous rhythmic contractions of the isolated ureter. Boiled garlic (5, 12.5, 25 and 50 mg/ml) had no effect on either ureteral motility or the PG synthesizing capacity of the sheep ureter.
Ali
M
M
Department of Clinical Physiology, Faculty of Health Sciences, University Hospital, Linkoping, Sweden.
Angelo-Khattar
M
M
Farid
A
A
Hassan
R A
RA
Thulesius
O
O
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005737:Garlic / Q000737:chemistry*; D006358:Hot Temperature; D007537:Isometric Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis*; D011863:Radioimmunoassay; D012756:Sheep; D014513:Ureter / Q000187:drug effects* / Q000378:metabolism; D014867:Water
D016861:Cyclooxygenase Inhibitors; D010276:Parasympatholytics; D010936:Plant Extracts; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D014867:Water; D016718:Arachidonic Acid