title: Analogues of classical antifolates bearing naphthoyl in place of benzoyl.
authors.affiliation: Southern Research Institute, Birmingham, Alabama 35255.
authors.forename: J R
authors.initials: JR
authors.lastname: Piper
authors.forename: C A
authors.initials: CA
authors.lastname: Johnson
authors.forename: J A
authors.initials: JA
authors.lastname: Maddry
authors.forename: J J
authors.initials: JJ
authors.lastname: McGuire
authors.forename: G M
authors.initials: GM
authors.lastname: Otter
authors.forename: F M
authors.initials: FM
authors.lastname: Sirotnak
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003196:Computer Graphics; D005260:Female; D005493:Folic Acid Antagonists / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D007939:Leukemia L1210; D015473:Leukemia, Promyelocytic, Acute; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D008727:Methotrexate / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D008958:Models, Molecular; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D012510:Sarcoma 180; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D005493:Folic Acid Antagonists; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate