title: Brain metastasis from clear cell sarcoma of the kidney--a case report and review of the literature.
abstract: We describe a 5 year old boy with a 5.5 cm right frontal lobe brain metastasis from primary clear cell sarcoma of the kidney without evidence of tumor-associated edema or contrast enhancement on either computed tomography or magnetic resonance imaging. The metastasis regressed but did not disappear with chemotherapy and dexamethasone, and the residual tumor was removed surgically. On histological examination the majority of the tumor was composed of mature connective tissue with a rim of typical renal clear cell sarcoma cells at the brain-tumor interface. The avascular and desmoplastic nature of the metastasis may explain the unusual radiographic features. Brain metastases from this tumor have only infrequently been reported; therefore a brief review of this rare tumor is provided.
authors.affiliation: Dept. of Clinical Neurological Sciences, Victoria Hospital, London, Ontario, Canada.
authors.forename: R L
authors.initials: RL
authors.lastname: Sahjpaul
authors.forename: D A
authors.initials: DA
authors.lastname: Ramsay
authors.forename: L L
authors.initials: LL
authors.lastname: de Veber
authors.forename: R F
authors.initials: RF
authors.lastname: Del Maestro
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003399:Craniotomy; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005625:Frontal Lobe / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D009392:Nephrectomy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin