Selective loss of calbindin D28K-immunoreactive neurons in the cortical layer II in brains of Alzheimer's disease: a morphometric study.
To investigate the relationship between neuronal death and intracellular calcium homeostasis in brains from patients with Alzheimer's disease (AD), we quantitatively analyzed morphological changes of calbindin-immunoreactive neurons. Neuronal counts were made in the autopsy brains from 6 control and 6 AD patients. Calbindin-immunoreactive neurons were mainly distributed in cortical layer II and were selectively lost in the AD brains. Further, the number of calbindin-immunoreactive neurons showed a negative correlation with age in the control group. These findings strongly suggest that age-related reduction of calbindin-immunoreactive neurons may be exaggerated in AD brains and change in calcium homeostasis may be involved in the pathogenesis of AD.
Nishiyama
E
E
Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
Ohwada
J
J
Iwamoto
N
N
Arai
H
H
D000367:Age Factors; D000368:Aged; D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000473:pathology*; D064092:Calbindin 1; D064026:Calbindins; D002540:Cerebral Cortex / Q000254:growth & development / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D012016:Reference Values; D064030:S100 Calcium Binding Protein G / Q000032:analysis*; D013702:Temporal Lobe / Q000473:pathology
C576498:CALB1 protein, human; D064092:Calbindin 1; D064026:Calbindins; D064030:S100 Calcium Binding Protein G