title: Influence of donor age on cadaver kidney graft function and survival: univariate and multivariate analyses.
abstract: The influence of donor age on the outcome of kidney transplantation (TX) was evaluated in 169 patients who received a primary cadaver kidney transplant at our center between September 16, 1984, and December 31, 1990. All the patients received cyclosporin A as part of the immunosuppressive protocol. Patients were grouped according to donor age: low donor age (LDA; donor age range 12-25 years), medium donor age (MDA; range 26-50 years) and higher donor age (HDA; range 51-66 years). There were no differences between groups in graft and patient survival, and multivariate analysis did not show any effect of donor age on those parameters. Proteinuria/day and number of rejection episodes did not differ between groups either. Immediate diuresis was more frequent in group LDA than in the other two groups (73.8, 54.7 and 57.1%, respectively; p < 0.05) and immediate diuresis resulted as a weak positive prognostic factor for graft outcome at multivariate analysis (p = 0.05). At both univariate and multivariate analyses, donor age resulted inversely correlated with creatinine clearance (CCr) at every period after TX but the 5th year, with r2 from 0.12 to 0.23 (p < 0.01). The LDA group had significantly better CCr than the HDA group at every period after TX but for the 5th year (the MDA group behaved intermediately).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Transplant Center, Treviso General Hospital, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Vianello
authors.forename: S
authors.initials: S
authors.lastname: Mastrosimone
authors.forename: G
authors.initials: G
authors.lastname: Calconi
authors.forename: A
authors.initials: A
authors.lastname: da Porto
authors.forename: G
authors.initials: G
authors.lastname: Palminteri
authors.forename: A
authors.initials: A
authors.lastname: D'Annibale
authors.forename: C
authors.initials: C
authors.lastname: Caldato
authors.forename: M C
authors.initials: MC
authors.lastname: Maresca
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D002102:Cadaver; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D014019:Tissue Donors
chemical_list: D016572:Cyclosporine