6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP, SUN 0588) acts on the brain muscarinic and nicotinic cholinergic receptors as evaluated by positron emission tomography (PET) in rhesus monkey.
Tani
Y
Y
Suntory Institute for Biomedical Research, Osaka, Japan.
Ishihara
T
T
Kanai
T
T
Ohno
T
T
Watanabe
Y
Y
Andersson
J
J
Lilija
A
A
Westerberg
G
G
Hartvig
P
P
Långström
B
B
D000818:Animals; D001590:Benztropine / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D001708:Biopterins / Q000031:analogs & derivatives* / Q000494:pharmacology; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D008253:Macaca mulatta; D009538:Nicotine / Q000378:metabolism; D009928:Organ Specificity; D010104:Oxygen Radioisotopes; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000379:methods
D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D010104:Oxygen Radioisotopes; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D019788:Fluorodeoxyglucose F18; D001590:Benztropine; D001708:Biopterins; D009538:Nicotine; D003847:Deoxyglucose; C003402:sapropterin