Global and regional ischaemia in left ventricular hypertrophy reactive to hypertension.
Hypertension has two main effects on the heart; it increases afterload, causing left ventricular hypertrophy, and precipitates the risk factor for coronary atherosclerosis. Left ventricular hypertrophy is an independent risk factor, but hypertension is a clustering of cardiovascular risks with many metabolic abnormalities, one of which is the recently described endocrinological Syndrome X (hyperinsulinaemia, resistance to insulin-stimulated glucose uptake, glucose intolerance, high triglyceride levels, low HDL and hypertension, which is apparently unrelated to the cardiological Syndrome X (angina with normal coronary arteries). However, the link between both Syndromes X may be the derangement of microvasculture, particularly endothelial dysfunction of nitric oxide (NO) production.
Zarco
P
P
Department of Cardiology, Universidad Complutense, Madrid, Spain.
D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D017566:Microvascular Angina / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000209:etiology; D009569:Nitric Oxide / Q000502:physiology*
D009569:Nitric Oxide