[Acute effects of hemodialysis on circulating parathormone, osteocalcin and alkaline phosphatase in patients with chronic renal failure].
The authors investigated biochemical indicators of the phosphocalcium metabolism in 18 patients dialyzed for prolonged periods on account of chronic renal failure before and after 5-hour dialysis. During dialysis serum creatinine and phosphorus levels declined and serum calcium levels rose. The level of immunoreactive parathyroid hormone (C-terminal), total alkaline phosphatase and gamma-glutamyl transferase did not change. During five hours of dialysis, as compared with alkaline phosphatase, mainly its bone isoenzyme, a marked increase of osteocalcin, an index of de novo bone formation, was recorded. From the investigation it is obvious that osteocalcin with a half-life of 5 minutes is an index of acute changes of the bone metabolism and its rise during dialysis indicates the favourable effect of dialysis on osteoblast activity.
Broulík
P
P
Interní klinika, 1. LF UK, Praha.
Hrubý
M
M
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D006435:Renal Dialysis
D010281:Parathyroid Hormone; D015675:Osteocalcin; D000469:Alkaline Phosphatase
Akutní úcinky hemodialýzy na cirkulující parathormon, osteokalcin a alkalickou fosfatázu u nemocných s chronickým renálním selháním.