[Antibodies to the structural proteins of the measles virus studied in some chronic diseases].
The qualitative and quantitative analysis of antibodies to measles virus (MV) structural proteins (SP) in sera from patients with chronic glomerulonephritis (CGN), chronic active hepatitis (CAH), and liver cirrhosis (LC) was done. The patients were shown to have neutralizing antibody titres (NAT) higher than those in healthy subjects. An analysis of antibodies to SP was carried out by the radioimmunoprecipitation assay. Antibodies were detected to hemagglutinin, nucleoprotein (NP), fusion protein and to matrix protein (M) both in sera from the patients with these chronic diseases, healthy subjects, and patients with active measles. (The two latter groups were selected for comparison). However, some patients with CAH and LC had no antibodies to M protein in spite of very high NAT. The quantitative analysis of MV antibodies to SP was done only for NP because this antibody had the least individual variations. The quantity of anti-NP antibodies was higher in most sera from patients with chronic diseases than in those from healthy subjects, and reached the level of that in patients with active measles. The presence of MV genome in the peripheral blood lymphocytes from patients CAH, CGN, and LC had been shown earlier. So it is assumed that MV persists in lymphoid tissue where the expression of all SP genes is realized.
Nikolaeva
L I
LI
Bogomolova
N N
NN
Filimonova
R G
RG
Borisova
V V
VV
Tikhonova
N T
NT
Mamaeva
T A
TA
Naumova
M A
MA
D000914:Antibodies, Viral / Q000097:blood*; D001345:Autoradiography; D002908:Chronic Disease; D004586:Electrophoresis; D005921:Glomerulonephritis / Q000276:immunology; D006521:Hepatitis, Chronic / Q000276:immunology; D006801:Humans; D008103:Liver Cirrhosis / Q000276:immunology; D008457:Measles / Q000276:immunology; D008459:Measles virus / Q000276:immunology*; D009500:Neutralization Tests; D015531:Radioimmunoprecipitation Assay; D015678:Viral Structural Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D015678:Viral Structural Proteins
Issledovanie antitel k strukturnym belkam virusa kori pri nekotorykh khronicheskikh zabolevaniiakh.