title: Increased plasma endothelin-1 concentrations in E. coli septic peritonitis rats with diabetes mellitus.
abstract: To study the diabetic mellitus (DM) patient's reaction to sepsis, we investigated the survival rate, the bacteremia, plasma endotoxin and plasma endothelin-1 levels in E. coli septic peritonitis rats with or without streptozotocin-induced DM. No significant difference could be detected between the DM and nondiabetic rats in the survival rate, the bacteremia level or the plasma endotoxin level. The DM rat manifested a significant increase compared to the nondiabetic rat in the plasma endothelin-1 level four hours after the outbreak of peritonitis. Endothelin-1 may thus play some role in the E. coli septic peritonitis rat with DM.
authors.affiliation: First Department of Surgery, Gunma University, School of Medicine, Maebashi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsukada
authors.forename: H
authors.initials: H
authors.lastname: Katoh
authors.forename: M
authors.initials: M
authors.lastname: Shiojima
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Takenoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Nagamachi
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000150:complications*; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D016232:Endothelins / Q000097:blood*; D004731:Endotoxins / Q000097:blood; D004927:Escherichia coli Infections; D008297:Male; D010538:Peritonitis / Q000097:blood* / Q000150:complications / Q000382:microbiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016232:Endothelins; D004731:Endotoxins