The gene for murine CTP:phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16.
CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J x Mus spretus)F1 x C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.
Rutherford
M S
MS
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Rock
C O
CO
Jenkins
N A
NA
Gilbert
D J
DJ
Tessner
T G
TG
Copeland
N G
NG
Jackowski
S
S
D000595:Amino Acid Sequence; D000818:Animals; D019916:Choline-Phosphate Cytidylyltransferase; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D015698:Genomic Library; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics*; D009713:Nucleotidyltransferases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D009713:Nucleotidyltransferases; D019916:Choline-Phosphate Cytidylyltransferase