title: Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
abstract: Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies. The results and the importance of serial neuropsychological examinations after such complications in three children with ALL are presented. All patients showed marked aphasia and other cognitive deficits. Recovery was complete in two of three children.
authors.affiliation: Division of Pediatric Oncology, University Hospital of Groningen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Kingma
authors.forename: R Y
authors.initials: RY
authors.lastname: Tamminga
authors.forename: W A
authors.initials: WA
authors.lastname: Kamps
authors.forename: R
authors.initials: R
authors.lastname: Le Coultre
authors.forename: R J
authors.initials: RJ
authors.lastname: Saan
mesh_terms: D000293:Adolescent; D001037:Aphasia / Q000209:etiology*; D001215:Asparaginase / Q000009:adverse effects*; D002561:Cerebrovascular Disorders / Q000139:chemically induced*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D001215:Asparaginase