Central angiotensin converting enzyme-blockade and thirst.
1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g). 2. Injection of lisinopril (2 micrograms/microliters) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group). 3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied.
Saad
W A
WA
Departamento de Fisiologia, Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara, SP, Brasil.
Luiz
A C
AC
Camargo
L A
LA
Menani
J V
JV
Renzi
A
A
Silveira
J E
JE
D000804:Angiotensin II / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D004326:Drinking / Q000187:drug effects*; D007279:Injections, Subcutaneous; D007545:Isoproterenol / Q000494:pharmacology; D017706:Lisinopril / Q000494:pharmacology; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012462:Saline Solution, Hypertonic; D013894:Thirst / Q000187:drug effects*; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D011092:Polyethylene Glycols; D017706:Lisinopril; D007545:Isoproterenol