Hypertensive effect of polyunsaturated dietary fat.
Male Sprague-Dawley rats were fed a diet high in either saturated fat (lard) or polyunsaturated fat (corn oil) beginning at 10 weeks of age. After 10 weeks of diet treatment, blood pressure (BP) was 17% higher in rats fed saturated fat and 8% higher in rats fed polyunsaturated fat than in rats fed a low-fat control diet. Rats fed the lard diet became obese, and their fasting insulin levels were elevated (38% above control). These data demonstrate that both saturated and polyunsaturated dietary fats induce hypertension.
Kaufman
L N
LN
Department of Physiology, Michigan State University, East Lansing 48824.
Peterson
M M
MM
Smith
S M
SM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003314:Corn Oil / Q000378:metabolism / Q000494:pharmacology; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects* / Q000494:pharmacology; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D007328:Insulin; D003314:Corn Oil; C029310:lard