Methylprednisolone therapy in laser injury of the retina.
The efficacy of methylprednisolone in argon-laser-induced retinal injury in primates was evaluated by clinical, histopathologic, and morphometric criteria. Methylprednisolone was given with a loading dose of 30 mg/kg followed by 5.4 mg/kg per hour in three different regimens: (1) starting 24 h before laser and continuing for 4 days; (2) starting immediately after laser and continuing for 4 days; and (3) starting immediately after laser and continuing for 8 h. Fundus photography, fluorescein angiography, and histologic examination showed significant beneficial effects of all three treatments compared to controls. Morphometrically, at the center of the lesion, the width of disrupted outer nuclear layer, the width of the affected RPE, and the percentage of residual photoreceptor nuclei confirmed the efficacies of treatment regimens 1 and 2, but not treatment regimen 3.
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Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, University of Illinois at Chicago, College of Medicine 60612.
Takahashi
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Fu
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Tso
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MO
D000818:Animals; D004195:Disease Models, Animal; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D007834:Lasers / Q000009:adverse effects*; D008252:Macaca fascicularis; D008775:Methylprednisolone / Q000627:therapeutic use*; D010786:Photoreceptor Cells / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D010857:Pigment Epithelium of Eye / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D012160:Retina / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*
D008775:Methylprednisolone