title: Miniaturized pressure-guide-wire: evaluation in vitro and in isolated hearts.
abstract: The present study focused on the accuracy and reproducability of measurements performed with a miniaturized pressure guidewire system (PGWS) under standardized in vitro conditions and in an isolated pig heart model. We used a pressure guide wire system provided by Pressure Guide, Radi Medical Systems, Uppsala, Sweden. Pressures were recorded by a fiber optic pressure sensor located laterally and 3 cm from the distal end. The basic principle is that the element modulates an optical reflection by pressure induced elastic movements. The light source is an emitting diode in the control unit. The PGWS replaces a standard 0.018 in. guidewire. The PGWS was introduced through a Y-adapter in a recirculating perfusion model, consisting of tubing with internal diameters from 1.00 to 4.00 mm. Different perfusion pressures (range 20-140 mm Hg) were generated by a pressure controlled roller pump.
  
  
  RESULTS
  Different lumen sizes from 1 to 4 mm had no influence on the measurements. a) In a range from 20 to 140 mm Hg no significant differences were found between the perfusion pressure and the pressures obtained by the PGWS, resulting in an r-value of 0.99 and an equation of y = 1.04x + 1.9. b) In pressure measurements proximal and distal of an artificial stenoses resulting in gradients from 0 to 100 mm Hg, the PGWS correctly identified the pressure difference with an equally high accuracy, 1, 2, and 3 cm behind the stenoses.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiology, University Hospital, II. Essen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Görge
authors.forename: R
authors.initials: R
authors.lastname: Erbel
authors.forename: S
authors.initials: S
authors.lastname: Niessing
authors.forename: F
authors.initials: F
authors.lastname: Schön
authors.forename: P
authors.initials: P
authors.lastname: Kearney
authors.forename: J
authors.initials: J
authors.lastname: Meyer
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D003251:Constriction, Pathologic; D003326:Coronary Circulation; D003327:Coronary Disease / Q000175:diagnosis; D003331:Coronary Vessels / Q000502:physiology*; D005069:Evaluation Studies as Topic; D066298:In Vitro Techniques; D008904:Miniaturization; D008961:Models, Structural; D011312:Pressure; D013552:Swine