Complement biosynthesis by mononuclear phagocytes.
Mononuclear phagocytes are an important in vivo source of a wide range of complement components. They are able to rapidly up-regulate or down-regulate complement synthesis in response to many different pharmacological and biological stimuli. This ability is likely to make a significant contribution to maintaining host defences particularly in peripheral tissues. The important role of molecular biology in the study of complement biosynthesis by mononuclear phagocytes will be emphasised.
McPhaden
A R
AR
Department of Cardiovascular Pathology, Texas Heart Institute, Houston 77201.
Whaley
K
K
D000818:Animals; D003167:Complement Activation / Q000502:physiology; D003165:Complement System Proteins / Q000096:biosynthesis* / Q000187:drug effects; D006801:Humans; D010586:Phagocytes / Q000276:immunology*
D003165:Complement System Proteins