Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein.
Westerhof
G R
GR
Dept. of Oncology, Free University Hospital, Amsterdam, The Netherlands.
Schornagel
J H
JH
Rijnboutt
S
S
Pinedo
H M
HM
Jansen
G
G
D000630:Aminopterin / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity; D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins / Q000096:biosynthesis / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000633:toxicity; D005493:Folic Acid Antagonists / Q000378:metabolism* / Q000633:toxicity*; D006801:Humans; D007624:KB Cells; D007700:Kinetics; D002955:Leucovorin / Q000378:metabolism; D008727:Methotrexate / Q000378:metabolism / Q000633:toxicity; D011799:Quinazolines / Q000378:metabolism / Q000633:toxicity; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists; D011799:Quinazolines; D011956:Receptors, Cell Surface; C031662:CB 3717; D005492:Folic Acid; C040210:edatrexate; D000630:Aminopterin; D002955:Leucovorin; D008727:Methotrexate