Cervical ripening induces labour through interleukin 1 beta.
In order to study the Interleukin 1 beta (IL-1 beta) levels in mechanical cervical ripening with Foley catheter, IL-1 beta levels in amniotic fluid of 12 women before and after cervical ripening were compared with those in 23 women in spontaneous active labour. IL-1 beta was present in 81.8% of patients after cervical ripening and in none prior to it. In women with spontaneous labour 69.6% had immunodetectable IL-1 beta. Women with spontaneous labour and those sampled after cervical ripening had similar IL-1 beta levels in the amniotic fluid. Cervical ripening with Foley catheter is associated with high levels of IL-1 beta and this probably induces labour.
George
S S
SS
Department of Obstetrics and Gynaecology, Christian Medical College and Hospital, Vellore, India.
Matthews
J
J
Jeyaseelan
L
L
Seshadri
L
L
D000653:Amniotic Fluid / Q000737:chemistry*; D002404:Catheterization; D002584:Cervix Uteri / Q000502:physiology*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis* / Q000502:physiology; D007751:Labor, Induced / Q000379:methods*; D007743:Labor, Obstetric / Q000378:metabolism*; D011247:Pregnancy
D007375:Interleukin-1