title: Hepatocellular adenoma in glycogen storage disease type IV.
abstract: The development of hepatocellular adenoma has been recognized in association with glycogen storage disease type I and, less often, with glycogen storage disease type III, but, to our knowledge, it has not been reported in glycogen storage disease type IV. We had the opportunity to study an 11-month-old male infant who underwent orthotopic liver transplantation for cirrhosis that developed in the setting of glycogen storage disease type IV. A clinically unsuspected hepatocellular adenoma was present in the explanted liver. Glycogen storage disease type IV should be considered as a potential precursor to the development of hepatocellular adenoma. Recognition of this association is important, both in terms of the differential diagnosis of tumors that occur in this setting and also to anticipate potential complications of this benign neoplasm.
authors.affiliation: Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, Calif. 90048.
authors.forename: N S
authors.initials: NS
authors.lastname: Alshak
authors.forename: J
authors.initials: J
authors.lastname: Cocjin
authors.forename: L
authors.initials: L
authors.lastname: Podesta
authors.forename: R
authors.initials: R
authors.lastname: van de Velde
authors.forename: L
authors.initials: L
authors.lastname: Makowka
authors.forename: P
authors.initials: P
authors.lastname: Rosenthal
authors.forename: S A
authors.initials: SA
authors.lastname: Geller
mesh_terms: D018248:Adenoma, Liver Cell / Q000209:etiology* / Q000473:pathology; D001706:Biopsy; D006011:Glycogen Storage Disease Type IV / Q000150:complications*; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male