title: A controlled comparison of the effects of propranolol, benztropine, and placebo on akathisia: an interim analysis.
abstract: A group of 28 patients was treated to compare the effects on akathisia of the following: propranolol (80 mg/day), benztropine (6 mg/day), or placebo. Both propranolol and benztropine significantly improved akathisia by Day 3-5 of treatment. Placebo had no significant effects of akathisia. Three patients developed confusion or forgetfulness by Day 3 of benztropine treatment; these effects cleared upon discontinuation of benztropine.
authors.affiliation: Psychiatry Service, New York Department of Veterans Affairs Medical Center, NY 10010.
authors.forename: L A
authors.initials: LA
authors.lastname: Adler
authors.forename: E
authors.initials: E
authors.lastname: Peselow
authors.forename: M
authors.initials: M
authors.lastname: Rosenthal
authors.forename: B
authors.initials: B
authors.lastname: Angrist
mesh_terms: D000328:Adult; D000368:Aged; D017109:Akathisia, Drug-Induced / Q000188:drug therapy*; D001590:Benztropine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use*; D016037:Single-Blind Method
chemical_list: D001590:Benztropine; D011433:Propranolol