Prognostic factors and relative risk in hypopharyngeal cancer--related parameters concerning stage, therapeutics and evolution.
The prognostic value of 16 parameters was evaluated in a series of 126 squamous cell carcinoma of hypopharynx between 1978 and 1985 at the "Serviço de Cirurgia de Cabeça e Pescoço" of the "Hospital Heliópolis", São Paulo. The variables considered were: age, sex, ethnic background, interval between diagnosis and detection of first symptom, extension of primary lesion (T), N categories, histologic evaluation of primary lesion (pT) and neck node metastasis (pN), number of clinical positive nodes (NGPOS), radiation, chemotherapy and recurrence of the disease (local, regional and distant metastasis). After a multifactorial study using Cox life table model (3) and Dixon mathematic-statistical model (8), 5 of those 16 parameters were found to influence survival, independently. The five variables organized according to hypopharynx cancer prognostic significance were: age, odynophagia, number of clinical (NGPRE) and histological (NGPOS) metastatic lymph nodes and radiation therapy; odynophagia and radiotherapy were the variables that decreased the relative risk of recurrence in the survival of cancer of the hypopharynx.
Rapoport
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Head and Neck Service, Hospital Heliópolis, São Paulo, Brasil.
Franco
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D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009333:Neck; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D015996:Survival Rate