[A comparative evaluation of the immunogenicity and reactogenicity of recombinant vaccines against hepatitis B].
Controlled epidemiological studies were carried out to evaluate two recombinant vaccines against hepatitis B of Cuban and Belgian production by the parameters of reactogenicity, safety and antigenic activity. Two groups of adult subjects (n = 73 each) and two groups of children (n = 30 each) were selected among those free from hepatitis B markers carrier state. The adults were given both preparations in a dose of 20 micrograms at intervals of 0-1-4 months, and the children received 10 micrograms at 0-1-2 months. The comparative studies showed both vaccines to be poorly reactogenic, safe and inducing anti-Hns in 80-100% of triply vaccinated subjects in titres within 100-500 IU. No statistically significant differences in the examined parameters were found in the two preparations tested.
Gorbunov
M A
MA
Pavlova
L I
LI
Noslova
A V
AV
Ikoev
V N
VN
Bektimirov
T A
TA
Voĭtenkov
M M
MM
Belyshev
B P
BP
Borisenko
I A
IA
Titov
I A
IA
D000293:Adolescent; D000328:Adult; D001530:Belgium; D002648:Child; D002675:Child, Preschool; D003462:Cuba; D004341:Drug Evaluation; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000009:adverse effects* / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007223:Infant; D013997:Time Factors; D014586:USSR; D014614:Vaccines, Synthetic / Q000009:adverse effects* / Q000276:immunology*
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic
Sravnitel'naia otsenka immunogennosti i reaktogennosti rekombinantnykh vaktsin protiv gepatita B.