[Effect of intraventricular hemorrhage in newborns on levels of certain prostanoids in blood plasma].
Recent studies suggest that eicosanoids might be involved in pathogenesis of vascular problems in preterm infants. The aim of the study was determine the concentrations most potent occurring vasoactive substances: Thromboxane A2 (TxA2) promoting vasoconstriction and prostacyclin (PGI2) causing vasodilation of vascular smooth muscles. We assessed the concentrations of stable metabolites TxA2-TxB2 and PGI2-6 keto PGF1 alpha in blood plasma by RIA method. It was found that neonates with RDS + IVH had significantly elevated TxB2 and 6 keto PGF1 alpha compared to healthy newborns, with transient tachypnoea and with RDS. High concentrations of thromboxane and prostacyclin metabolites in newborns plasma with IVH suggest a causative role of eicosanoids in pathogenesis of haemorrhage. The cells of impaired blood vessels may be probable source of these eicosanoids.
Szczapa
J
J
Kliniki Neonatologii Instytutu Ginekologii i Połoznictwa AM, Poznaniu.
Kornacka
M
M
Rychlik
K
K
D002543:Cerebral Hemorrhage / Q000097:blood*; D002552:Cerebral Ventricles; D011464:Epoprostenol / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D011453:Prostaglandins / Q000097:blood*; D012016:Reference Values; D013928:Thromboxane A2 / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D011453:Prostaglandins; D013929:Thromboxane B2; D013928:Thromboxane A2; D011464:Epoprostenol
Wpływ krwawienia dokomorowego u wcześniaków na stezenie niektórych prostanoidów w osoczu krwi.