c-fos and NGFI-A mRNA of rat retina: evidence for light-induced augmentation and a role for cholinergic and glutamate receptors.
When rats are exposed to room light from the dark, there is a transient increase of mRNA for the immediate-early genes c-fos and NGFI-A in the retina. Augmentation of c-fos and NGFI-A mRNA by light is apparently associated with activation of cholinergic nicotinic and muscarinic receptors as it can be suppressed by the nicotinic antagonist mecamylamine and the muscarinic antagonist atropine. Moreover, the light-induced increase of c-fos mRNA in retina appears to be associated with activation of glutamate receptors also as the noncompetitive inhibitor of N-methyl-D-aspartate receptors dizocilpine (MK-801) partially suppressed the increase of the c-fos message. Light-induced NGFI-A mRNA augmentation is apparently modulated by the same receptors. We were unable to detect light-induced changes of c-jun mRNA.
Gudehithlu
K P
KP
Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210-1239.
Neff
N H
NH
Hadjiconstantinou
M
M
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D051766:Early Growth Response Protein 1; D017874:Immediate-Early Proteins; D008027:Light; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011950:Receptors, Cholinergic / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors; D012160:Retina / Q000378:metabolism* / Q000528:radiation effects*; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D011950:Receptors, Cholinergic; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D014157:Transcription Factors; D008464:Mecamylamine