title: In situ remineralization of enamel lesions using continuous versus intermittent fluoride application.
abstract: Remineralization of early enamel lesions was studied in situ using a F chewing gum or a F-releasing device (FRD). Enamel specimens with subsurface lesions were mounted in removable lower appliances in 6 adults. A F-free dentifrice was used for all regimens. Test groups chewed five sticks/day (0.1 mg F/stick), or one FRD (0.5 mg F/day) was mounted in the midline of the appliance. The microhardness was measured after the 21-day intraoral exposure, and in vitro acid resistance testing was performed. Separate specimens were used to measure F content or changes in mineral density. Comparable values for both F gum and FRDs were higher (p > 0.05) than controls for acid resistance testing and percent remineralization. The F content for FRDs exceeded that of both F gum and controls.
authors.affiliation: School of Dentistry, University of Michigan, Ann Arbor 48109-1078.
authors.forename: C W
authors.initials: CW
authors.lastname: Wang
authors.forename: R E
authors.initials: RE
authors.lastname: Corpron
authors.forename: W J
authors.initials: WJ
authors.lastname: Lamb
authors.forename: D S
authors.initials: DS
authors.lastname: Strachan
authors.forename: C J
authors.initials: CJ
authors.lastname: Kowalski
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002638:Chewing Gum; D004245:DMF Index; D003692:Delayed-Action Preparations; D003743:Dental Enamel / Q000378:metabolism*; D005260:Female; D005460:Fluorides, Topical / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017001:Tooth Demineralization / Q000378:metabolism*; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002638:Chewing Gum; D003692:Delayed-Action Preparations; D005460:Fluorides, Topical