title: Withdrawing long-term diuretic therapy in the elderly: a study in general practice in The Netherlands.
abstract: BACKGROUND
  About 20% of all men and women age 65 or older are on maintenance therapy with diuretics. Multiple drug use and side effects increase with age whereas a clear indication for long-term diuretic therapy is not always present. The aim of the present study was to assess whether in some patients long-term diuretic therapy could be withdrawn in general practice.
  
  
  METHODS
  This study is a pilot-study for a large multicentered randomized controlled trial in general practice. In one general practice in The Netherlands, 15 diuretic-using patients were selected from a total population of 52. All had been using diuretics for more than six months, were not hypertensive, and did not show overt symptoms of heart failure. In these 15 patients, diuretic medication was withdrawn under careful medical monitoring conditions.
  
  
  RESULTS
  After six months, six patients were still without diuretic therapy. Diuretic therapy had to be resumed in nine cases, because of congestive heart failure (one), hypertension (three), bronchial asthma (one), increased ankle edema (two) and subjective complaints (two). The withdrawal of diuretic therapy caused an increase in mean systolic blood pressure, heart failure score, body weight and ankle edema.
  
  
  CONCLUSIONS
  Long-term maintenance diuretic therapy in patients age 65 or older in general practice may be successfully withdrawn in selected cases. Careful medical surveillance during and after withdrawal is warranted.
authors.affiliation: Department of General Practice, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: E P
authors.initials: EP
authors.lastname: Walma
authors.forename: A W
authors.initials: AW
authors.lastname: Hoes
authors.forename: A
authors.initials: A
authors.lastname: Prins
authors.forename: F S
authors.initials: FS
authors.lastname: Boukes
authors.forename: E
authors.initials: E
authors.lastname: van der Does
mesh_terms: D000368:Aged; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005194:Family Practice; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008134:Long-Term Care; D008297:Male; D009426:Netherlands; D010865:Pilot Projects
chemical_list: D004232:Diuretics