[Modification of the mutagenicity of drugs by their immobilization. Effect of immobilization of analgin in starch in mice].
The mutagenic effect of analgin was studied in germ and somatic cells of male mice Mus musculus. It was found that injection of analgin (20 and 40 mg per mouse) significantly increased the frequency of sperm head anomalies and chromosome aberrations in bone marrow cells. Immobilization of analgin in starch led to decrease in the drug immobilization.
Mikheev
V S
VS
Togo
E F
EF
Pol'kina
S I
SI
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004177:Dipyrone / Q000633:toxicity*; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D013077:Sperm Head / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013213:Starch
D009153:Mutagens; D004177:Dipyrone; D013213:Starch
Modifikatsiia mutagennosti lekarstvennykh preparatov putem ikh immobilizatsii. Effekt immobilizatsii anal'gina v krakhmale u mysheĭ.