Comparison of nitrendipine and cilazapril in patients with hypertension and non-insulin-dependent diabetes mellitus.
The metabolic and cardiovascular effects of nitrendipine and cilazapril in patients who have elevated blood pressure and non-insulin-dependent diabetes mellitus (NIDDM) were compared. After at least 6 weeks of a washout period, 20 NIDDM patients who had diastolic blood pressure in the range of 90-105 mm Hg received a single-blind placebo for 4 weeks and then were randomized to receive 20 mg nitrendipine once daily and 5 mg cilazapril once daily each for 12 weeks according to a crossover, double-blind procedure. Nitrendipine and cilazapril reduced diastolic blood pressure levels 12% and 13%, left ventricular mass index (LVMI) levels 13% and 12%, and raised whole glucose disposal levels 18% and 19.5%, respectively. Only nitrendipine reduced glucose-stimulated insulin levels. Nitrendipine is as effective as cilazapril in lowering diastolic blood pressure and LVMI levels and in increasing glucose disposal levels in these patients.
Giugliano
D
D
Department of Geriatrics and Metabolic Diseases, Faculty of Medicine, Second University of Naples, Italy.
De Rosa
N
N
Marfella
R
R
Di Maro
G
G
Cacciapuoti
F
F
Quatraro
A
A
Acampora
R
R
D'Onofrio
F
F
D001794:Blood Pressure / Q000502:physiology; D017315:Cilazapril / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000627:therapeutic use*; D013997:Time Factors
D017315:Cilazapril; D009568:Nitrendipine