A study of the relationship between susceptibility to skin stinging and skin irritation.
In an evaluation of the safety of new chemicals, of products containing them, or of novel formulations of existing chemicals which may come into contact with the skin, it is important to incorporate an assessment of specially susceptible sub-populations. Such a group is represented by those who are more likely to experience sensory effects such as stinging. Since these individuals are easily and rapidly identifiable, we investigated whether they represented a group who were also more susceptible to the effects of an irritant. The primary purpose was to discover whether 'stingers' might represent an easily and rapidly identifiable sub-population with a more generally increased tendency to give skin responses. The response to a 0.3% sodium dodecyl sulphate patch test was assessed in a group of 25 'stingers' and compared to the response in 25 'non-stingers'. There was no difference in either the pattern or strength of the irritant response assessed by subjective erythema and dryness scores. Thus the data suggest that there is no correlation between the susceptibility of an individual to a skin stinging response and an irritation reaction.
Basketter
D A
DA
Unilever Environmental Safety Laboratory, Sharnbrook, Beds., UK.
Griffiths
H A
HA
D004890:Erythema / Q000473:pathology; D005260:Female; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D007773:Lactates / Q000009:adverse effects; D019344:Lactic Acid; D008297:Male; D017288:Pain Threshold; D010292:Paresthesia / Q000139:chemically induced; D010328:Patch Tests; D012867:Skin / Q000276:immunology* / Q000473:pathology; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects*
D007509:Irritants; D007773:Lactates; D019344:Lactic Acid; D012967:Sodium Dodecyl Sulfate