title: Carbamazepine (Tegretol)-induced thrombocytopenia.
abstract: A case of carbamazepine-induced thrombocytopenia is reported. The patient, a 38-year-old female, developed thrombocytopenia 10 days after receiving 400 mg carbamazepine daily. The presence of an anti-IgG carbamazepine-dependent platelet-reactive antibody was documented. Using flow cytometry, the drug-induced antibody was detected at a drug concentration as low as 10(-6) M.
authors.affiliation: Hematology Institute, Ramabam Medical Center, Haifa, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Shechter
authors.forename: B
authors.initials: B
authors.lastname: Brenner
authors.forename: E
authors.initials: E
authors.lastname: Klein
authors.forename: I
authors.initials: I
authors.lastname: Tatarsky
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D002220:Carbamazepine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D002220:Carbamazepine