title: Dietary cholesterol lowers the activity of butyrylcholinesterase (EC 3.1.1.8), but elevates that of esterase-1 (EC 3.1.1.1) in plasma of rats.
abstract: The question addressed is whether an increased intake of cholesterol affects esterase-1 (EC 3.1.1.1; ES-1) and butyrylcholinesterase (EC 3.1.1.8) activity in plasma. Rats were fed on a purified diet either without or with cholesterol (10 g/kg) added at the expense of the carbohydrate source. Dietary cholesterol significantly decreased plasma butyrylcholinesterase activity, but raised plasma ES-1 activity. Evidence is discussed, suggesting that plasma butyrylcholinesterase is involved in plasma cholesterol metabolism, whereas esterase-1 is involved in intestinal cholesterol absorption.
authors.affiliation: Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: H A
authors.initials: HA
authors.lastname: Van Lith
authors.forename: A C
authors.initials: AC
authors.lastname: Beynen
mesh_terms: D000818:Animals; D002091:Butyrylcholinesterase / Q000097:blood*; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007408:Intestinal Absorption / Q000502:physiology; D008099:Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002791:Cholesterol, Dietary; D002784:Cholesterol; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D002091:Butyrylcholinesterase