[Activity of antioxidant defense enzymes and the state of lipid peroxidation in the rat brain in decis and dichlofos poisoning].
The activity of the antioxidant system enzymes--superoxide dismutase (SOD) and catalase and lipids peroxidation in the rat brain under deltametrin and dichlorvos intoxication has been studied in vivo. It was shown that both xenobiotics lowered SOD activity 30 minutes after the injection. Accumulation of superoxide ions as a result of inhibition of SOD activity may stimulate lipid peroxidation of biological membranes. Activation of lipid peroxidation in the rat brain in vivo under dichlorvos and deltametrin intoxication was established. It was shown in the in vitro experiments that deltametrin (but not dichlorvos) stimulated NADPH-induced lipid peroxidation.
Syrovatskaia
L P
LP
Sereda
P I
PI
Gromov
L A
LA
Filonenko
M A
MA
Ovinova
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002374:Catalase / Q000187:drug effects*; D004006:Dichlorvos / Q000506:poisoning*; D005260:Female; D007306:Insecticides / Q000506:poisoning*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009570:Nitriles; D011722:Pyrethrins / Q000506:poisoning*; D051381:Rats; D013482:Superoxide Dismutase / Q000187:drug effects*
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D004006:Dichlorvos; D002374:Catalase; D013482:Superoxide Dismutase
Aktivnost' fermentov antioksidantnoĭ zashchity i sostoianie protsessov perekisnogo okisleniia lipidov v mozge krys pri intoksikatsii detsisom i dikhlofosom.