title: Recurrent t(12;19)(q13;q13.3) in intracranial and extracranial hemangiopericytoma.
abstract: We report on a recurrent intracranial hemangiopericytoma cytogenetically studied after short-term culture. The tumor had a uniform karyotype 47,XX,add(7)(q21),t(12;19)(q13;q13.3),del(13)(q14q22), +21. Remarkably, one case with an identical reciprocal (12;19) translocation has been previously reported as the sole cytogenetic change in a recurrent retroperitoneal hemangiopericytoma. This nonrandom structural change may characterize a subentity of hemangiopericytoma and might be of diagnostic value.
authors.affiliation: Institute of Human Genetics, University of the Saar, Homburg/Saar, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Henn
authors.forename: B
authors.initials: B
authors.lastname: Wullich
authors.forename: M
authors.initials: M
authors.lastname: Thönnes
authors.forename: W I
authors.initials: WI
authors.lastname: Steudel
authors.forename: W
authors.initials: W
authors.lastname: Feiden
authors.forename: K D
authors.initials: KD
authors.lastname: Zang
mesh_terms: D000782:Aneuploidy; D002528:Cerebellar Neoplasms / Q000235:genetics* / Q000648:ultrastructure; D002530:Cerebellopontine Angle; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure*; D002888:Chromosomes, Human, Pair 19 / Q000648:ultrastructure*; D005260:Female; D006393:Hemangiopericytoma / Q000235:genetics* / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D012186:Retroperitoneal Neoplasms / Q000235:genetics / Q000648:ultrastructure; D014178:Translocation, Genetic