title: Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. I.
abstract: From rhizomes and roots of Panax vietnamensis Ha et Grushv., Araliaceae, commonly known as Vietnamese Ginseng, two new acetylate saponins named vina-ginsenoside-R1 (13) and vina-ginsenoside-R2 (15) were isolated. On the basis of chemical and spectral data, 13 was formulated as monoacetyl 24(S)-pseudo-ginsenoside-F11 and 15 was proved to be monoacetyl majonside-R2. Besides the two new saponins and beta-sitosteryl-3-O-beta-D-glucopyranoside, sixteen known saponins were also isolated and identified. Dammarane saponins:ginsenoside-Rh1 and 20(R)-ginsenoside-Rh1 (1), ginsenosides-Rg1 (2), -Re (3), -Rd (6), -Rb3 (7), -Rb2 (8), -Rb1 (9), pseudo-ginsenoside-RS1 (= monoacetyl ginsenoside-Re, 4), notoginsenosides-R1 (5) and -Fa (10). Ocotillol-type saponins:pseudo-ginsenoside-RT4 (11), 24(S)-pseudo-ginsenoside-F11 (12), majonosides-R1 (16) and -R2 (14). Oleanolic acid saponins:ginsenoside-Ro (= chikusetsusaponin V, 17) and hemsloside-Ma3 (18), a saponin previously isolated from a cucurbitaceous plant, Hemsleya macrosperma C. Y. Wu. Despite having large horizontally elongated rhizomes, the underground part of this plant contains mainly dammarane saponins and a small amount of oleanolic acid saponins. In addition, the yield of ocotillol-type saponins, especially majonoside-R2, is surprisingly very high (more than 5% and ca. half of the total yield of saponin). This characteristic saponin composition has made Vietnamese Ginseng an interesting species among Panax spp.
authors.affiliation: Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh City University of Medicine and Pharmacy.
authors.forename: M D
authors.initials: MD
authors.lastname: Nguyen
authors.forename: T N
authors.initials: TN
authors.lastname: Nguyen
authors.forename: R
authors.initials: R
authors.lastname: Kasai
authors.forename: A
authors.initials: A
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Yamasaki
authors.forename: O
authors.initials: O
authors.lastname: Tanaka
mesh_terms: D036145:Ginsenosides / Q000737:chemistry* / Q000302:isolation & purification; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D014744:Vietnam
chemical_list: D036145:Ginsenosides; D012503:Saponins; C000608354:vina-ginsenoside R2