title: Effect of toxins 544 and 514 from Karwinskia humboldtiana (buckthorn) plant upon fetal development of the mouse.
abstract: The teratogenic effect of toxins 544 and 514 from K. humboldtiana upon the mouse embryo was evaluated. One half of the LD50 dose for the mouse was administered at day 8 of gestation. At the end of pregnancy, reproduction and fetal data were recorded. Dams treated with toxin 544, but not with toxin 514, showed a higher incidence of reabsorptions, malformations, as well as lower fetal length compared to the control group.
authors.affiliation: Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo Leoń, Monterrey, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Valadez-Alvizo
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Alvarado
authors.forename: L
authors.initials: L
authors.lastname: Martínez de Villarreal
authors.forename: R
authors.initials: R
authors.lastname: González-Alanís
authors.forename: A
authors.initials: A
authors.lastname: Piñeyro-López
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011714:Pyrans / Q000633:toxicity*; D031955:Rhamnus / Q000737:chemistry*; D013723:Teratogens / Q000633:toxicity*; D014118:Toxins, Biological / Q000633:toxicity*
chemical_list: D000873:Anthracenes; D011714:Pyrans; D013723:Teratogens; D014118:Toxins, Biological; C075149:Karwinskia toxin T-514; C075148:Karwinskia toxin T-544