Changes of spirodecanone binding in the gerbil hippocampus after cerebral ischaemia.
Using quantitative receptor autoradiography, spirodecanone binding was evaluated in the gerbil hippocampus 1 h-1 month after cerebral ischaemia of 10 min. The spirodecanone binding was unaffected in the hippocampus up to 48 h after ischaemia. Thereafter, increased binding was found in the stratum radiatum of hippocampal CA1 sector 7 days and 1 month after ischaemia. Other hippocampal regions showed no significant alterations in the spirodecanone binding. A histological study revealed that the hippocampal CA1 sector was severely damaged 7 days and 1 months after ischaemia. These results demonstrate that spirodecanone binding sites are located on interneurones or glial cells in the hippocampal CA1 sector.
Araki
T
T
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Murakami
F
F
Kanai
Y
Y
Kato
H
H
Kogure
K
K
D000818:Animals; D001345:Autoradiography; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D011712:Pyramidal Tracts / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D013141:Spiro Compounds / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium
D011954:Receptors, Dopamine; D013141:Spiro Compounds; C038349:spirodecanone receptor; D014316:Tritium; C014826:spirodecanone; D013134:Spiperone