title: [Chemoprophylactic activity on Schistosomiasis mansoni of soaps containing essential oil from the fruits of Pterodon pubescens].
abstract: The chemoprophylactic action of the essential oil of the fruit of Pterodon pubescens Benth (Leguminosae), incorporated in different soap formulations, was studied in experimental schistosomiasis. The formulations were used locally on the tails of mice which were exposed to Schistosoma mansoni cercariae immediately, 24, 72 or 168 hours later by the method of tail immersion. Protection was evaluated 45 days after exposure when the mice were sacrificed and the worms collected by perfusion. The results showed levels of protection varying from 0.0 to 100% depending on the formulation used. A methodology that allowed the evaluation of soap protection of mice exposed to natural infection in snail infested streams on the outskirts of Belo Horizonte, MG, was also developed. Promising results were obtained in that protection of between 57.5 and 31.1% was observed in field trials when soap was applied to the animals 24 and 48 hours earlier. Preliminary studies evaluating irritation and toxicity were favorable and showed that this new prophylactic weapon could contribute to the control of schistosomiasis.
authors.affiliation: Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Ministério da Saúde, Belo Horizonte, Minas Gerais, Brasil.
authors.forename: N
authors.initials: N
authors.lastname: Katz
authors.forename: D
authors.initials: D
authors.lastname: dos Santos Filho
authors.forename: S J
authors.initials: SJ
authors.lastname: Sarti
authors.forename: N M
authors.initials: NM
authors.lastname: Mendes
authors.forename: P A
authors.initials: PA
authors.lastname: Rocha Filho
authors.forename: N
authors.initials: N
authors.lastname: Araujo
mesh_terms: D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D009822:Oils, Volatile / Q000008:administration & dosage*; D010946:Plants, Medicinal; D051381:Rats; D012555:Schistosomiasis mansoni / Q000517:prevention & control*; D012915:Soaps / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D009822:Oils, Volatile; D012915:Soaps
vernacular_title: Atividade quimioprofilática na esquistossomose mansoni de sabonetes contendo óleo essencial de frutos de Pterodon pubescens.