title: Role of lipoproteins in progressive renal disease.
abstract: Renal diseases are often associated with hyperlipoproteinemia and dyslipoproteinemia. Total serum cholesterol and triglycerides are increased in nephrotic syndrome regardless of etiology. Approximately 40 to 50% of patients with renal insufficiency requiring hemodialysis show hypertriglyceridemia and dyslipoproteinemia. During chronic hemodialysis, high doses of unfractionated heparin deplete post-heparin lipolytic activity and aggravate dyslipoproteinemia. Hypercholestrolemia and hyperlipoproteinemia are often encountered in patients taking glucocorticoids and cyclosporin A after renal transplantation. Observations in experimental animals and in patients with genetically determined and acquired hyperlipidemias suggest that lipids can damage the kidney and lead to glomerulosclerosis. In vitro cell-culture studies of human glomerular cells have been useful in providing information on lipid-induced glomerular damage. Thus, there are strong indications that lipoproteins may play a critical role in the development of mesangial cell damage and progressive renal disease. Therapeutic measures that reduce and correct dyslipoproteinemia in renal disease may have long-term beneficial effects on the amelioration of renal disease.
authors.affiliation: Department of Clinical Chemistry, Grosshadern Clinic, University of Munich, Germany.
authors.forename: A K
authors.initials: AK
authors.lastname: Walli
authors.forename: E
authors.initials: E
authors.lastname: Gröne
authors.forename: B
authors.initials: B
authors.lastname: Miller
authors.forename: H J
authors.initials: HJ
authors.lastname: Gröne
authors.forename: J
authors.initials: J
authors.lastname: Thiery
authors.forename: D
authors.initials: D
authors.lastname: Seidel
mesh_terms: D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D008074:Lipoproteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D008074:Lipoproteins