title: Substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides: a new class of potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G.
abstract: A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion.
authors.affiliation: Department of Chemistry, Wichita State University, KS 67260.
authors.forename: W C
authors.initials: WC
authors.lastname: Groutas
authors.forename: R
authors.initials: R
authors.lastname: Kuang
authors.forename: R
authors.initials: R
authors.lastname: Venkataraman
mesh_terms: D056649:Cathepsin G; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000097:blood; D003499:Cyclic S-Oxides / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D019272:Leukocyte Elastase; D007962:Leukocytes / Q000201:enzymology*; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000097:blood; D012697:Serine Endopeptidases; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D003499:Cyclic S-Oxides; D013830:Thiadiazoles; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase