DAU 6215, a novel 5-HT3 receptor antagonist, improves performance in the aged rat in the Morris water maze task.
The effects of the new 5-HT3 receptor antagonist, DAU 6215, on aged rats' cognition were assessed in the Morris water maze task. Task performance of aged animals that received acutely the dose of 10 micrograms/kg IP was not different than that of their aged controls treated with the vehicle. Conversely, a repeated IP administration of 10 micrograms/kg DAU 6215 for 3 weeks significantly improved task performance of the aged animals as compared to that displayed by the old rats treated with the vehicle.
Pitsikas
N
N
Department of Pharmacology, Boehringer Ingelheim Italia, S.p.A., Milano.
Brambilla
A
A
Borsini
F
F
D000375:Aging / Q000523:psychology*; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003071:Cognition / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects
D001562:Benzimidazoles; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D012702:Serotonin Antagonists; C070191:itasetron