title: Immunoglobulin-producing tumours in dogs and cats.
abstract: Tumours with a plasmacytoid pattern taken from 32 dogs and four cats were examined for the presence of immunoglobulins, which would allow them to be designated as B-cell lymphomas. Within a total of 19 immunoglobulin-positive tumours, three types could be distinguished: extramedullary plasmacytoma (15), multiple myeloma (two) and immunocytoma (two). These tumours occurred in 18 of the dogs, and in one cat (extramedullary plasmacytoma). The characteristics of the immunoglobulin-producing tumours were investigated by light and electron-microscopy as well as by immunohistochemical methods. Seventeen of the 19 tumours expressed lambda-type light chains and one tumour kappa-type light chains. Heavy chains were also synthesized by five tumours.
authors.affiliation: Institute of Veterinary Pathology, University of Munich, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Breuer
authors.forename: F
authors.initials: F
authors.lastname: Colbatzky
authors.forename: S
authors.initials: S
authors.lastname: Platz
authors.forename: W
authors.initials: W
authors.lastname: Hermanns
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000378:metabolism* / Q000473:pathology; D002415:Cats; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D007070:Immunoglobulin A / Q000032:analysis / Q000378:metabolism; D007074:Immunoglobulin G / Q000032:analysis / Q000378:metabolism; D007075:Immunoglobulin M / Q000032:analysis / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000378:metabolism; D007136:Immunoglobulins / Q000032:analysis / Q000378:metabolism*; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000737:chemistry / Q000378:metabolism / Q000662:veterinary*; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000378:metabolism / Q000662:veterinary*; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000378:metabolism / Q000662:veterinary*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins