How alpha beta T-cell receptors 'see' peptide/MHC complexes.
Recent results have added new information to our understanding of alpha beta T-cell receptor mediated recognition. In particular, we find that the V(D)J junction or 'CDR3' portion of TCR alpha and beta seem most important in contacting peptides bound to MHC molecules, consistent with previous predictions. Surprisingly, these same CDR3-peptide contacts also appear to have a major influence on the TCR-MHC molecule interactions as well.
Chien
Y H
YH
Dept of Microbiology and Immunology, Stanford University School of Medicine, CA 94305-5402.
Davis
M M
MM
D000595:Amino Acid Sequence; D000818:Animals; D003574:Cytochrome c Group / Q000235:genetics / Q000276:immunology; D006825:Hybridomas; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D008969:Molecular Sequence Data; D009036:Moths / Q000201:enzymology; D010455:Peptides / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D003574:Cytochrome c Group; D007135:Immunoglobulin Variable Region; D010455:Peptides; D016693:Receptors, Antigen, T-Cell, alpha-beta