Hamster hepatic amyloid A (AA) protein is derived from a novel member of the SAA gene family.
The nearly complete amino acid sequence of casein-induced hepatic hamster AA is described. Hamster AA appeared to be C-terminally ragged as found in other species. Furthermore, the N-terminus was (partially) truncated. Hamster hepatic AA sequence showed high homology with, but was not identical to hamster SAA-isotype sequences deduced earlier from mRNA in hepatic and extra-hepatic tissue. Therefore, hamster hepatic AA is derived from a novel member of the SAA gene family. However, the origin of hepatic AA-amyloid remains unclear.
Niewold
T A
TA
Department of Medicine, University of Tennessee, Knoxville.
Murphy
C
C
Gruys
E
E
D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D008099:Liver / Q000737:chemistry*; D008297:Male; D008647:Mesocricetus; D008969:Molecular Sequence Data; D005810:Multigene Family; D010446:Peptide Fragments / Q000737:chemistry; D016415:Sequence Alignment; D000685:Serum Amyloid A Protein / Q000737:chemistry* / Q000235:genetics
D010446:Peptide Fragments; D000685:Serum Amyloid A Protein