Effects of induced electric fields on finite neuronal structures: a simulation study.
In this paper we present an analysis of magnetic stimulation of finite length neuronal structures using computer simulations. Models of finite neuronal structures in the presence of extrinsically applied electric fields indicate that excitation can be characterized by two driving functions: one due to field gradients and the other due to fields at the boundaries of neuronal structures. It is found that boundary field driving functions play an important role in governing excitation characteristics during magnetic stimulation. Simulations indicate that axons whose lengths are short compared to the spatial extent of the induced field are easier to excite than longer axons of the same diameter. Simulations also indicate that independent cellular dendritic processes are probably not excited during magnetic stimulation. Analysis of the temporal distribution of induced fields indicates that the temporal shape of the stimulus waveform modulates excitation thresholds and propagation of action potentials.
Nagarajan
S S
SS
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Durand
D M
DM
Warman
E N
EN
D000818:Animals; D001369:Axons / Q000502:physiology; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology; D004574:Electromagnetic Fields; D008322:Mammals; D008959:Models, Neurological; D010812:Physical Stimulation / Q000379:methods*