[Effect of supposed radioprotectors on oxidation-reduction of vitamin E in the tissues of irradiated rats].
In experiments with mature Wistar male rats under irradiation by dose of 5 Gy the effect of emoxypine, citomedine and echinacea purpurea on the content of liposoluble vitamin A, carotene, vitamin E and its metabolites (quinone and oxidized tocopherol) in blood plasma, spleen, liver and testes was studied. It was shown the drugs under study mobilized the internal reserves of these vitamins and promoted effective functioning of vitamin E redox system. Mechanisms of their action are different. The drugs might be used as radioprotectors, but they exhaust the reserves of the liposoluble vitamins. Therefore they should be used in a combination with vitamin preparations.
Paranich
A V
AV
Pocherniaeva
V F
VF
Dubinskaia
G M
GM
Mishchenko
V P
VP
Mironova
N G
NG
Gugalo
V P
VP
Nazarets
V V
VV
D000818:Animals; D016227:Benzoquinones / Q000378:metabolism; D002338:Carotenoids / Q000378:metabolism*; D020900:Echinacea; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D010084:Oxidation-Reduction; D010455:Peptides / Q000493:pharmacokinetics / Q000494:pharmacology*; D010847:Picolines / Q000493:pharmacokinetics / Q000494:pharmacology*; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D010946:Plants, Medicinal; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects; D013737:Testis / Q000378:metabolism / Q000528:radiation effects; D014801:Vitamin A / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism*
D016227:Benzoquinones; D010455:Peptides; D010847:Picolines; D010936:Plant Extracts; D011837:Radiation-Protective Agents; C053892:cytomedins; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; C004532:quinone; C030210:echinacin; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Izuchenie vliianiia predpolagaemykh radioprotektorov na sostoianie redoks-sistemy vitamina E v tkaniakh obluchënnykh krys.