Relationship between disease activity and ANCA level by ELISA in the long-term management of vasculitis.
Solid-phase immunoassays were used to examine the relationship between ANCA concentration and disease activity during follow-up of 63 patients with systemic vasculitis. ANCA levels fell with induction therapy. Relapses during long-term follow-up were generally associated with high or rising ANCA concentrations, although the temporal relationship between clinical relapse and changes in ANCA was variable.
De'Oliviera
J
J
Department of Medicine, Royal Postgraduate Medical School, London, UK.
Gaskin
G
G
Dash
A
A
Rees
A J
AJ
Pusey
C D
CD
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D014657:Vasculitis / Q000097:blood* / Q000188:drug therapy*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; D003520:Cyclophosphamide; D011239:Prednisolone