title: [Spontaneous ecchymosis disclosing acquired factor VIII inhibitor].
abstract: An 81-year old woman suddenly developed extensive ecchymosis. A factor VIII:c inhibitor was detected. She received porcine factor VIII, corticosteroids, intravenous immunoglobulins and cyclophosphamide. Normalization of factor VIII level was achieved in 1 month. The patient died, 3 months later, of congestive heart failure. Spontaneous development of factor VIII inhibitors is an extremely rare event which usually occurs in dramatic bleeding. Many associated diseases have been reported. Patients with serious bleeding should be given porcine factor VIII. Immunosuppressive therapy consists of corticosteroids, cyclophosphamide and intravenous immunoglobulins.
authors.affiliation: Service de Médecine Interne, Centre d'Allergie, Hôpital Rothschild, Paris.
authors.forename: O
authors.initials: O
authors.lastname: Bayrou
authors.forename: A
authors.initials: A
authors.lastname: Deschamps
authors.forename: C
authors.initials: C
authors.lastname: Laurian
authors.forename: C
authors.initials: C
authors.lastname: Braunstein
authors.forename: F
authors.initials: F
authors.lastname: Leynadier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001778:Blood Coagulation Disorders / Q000209:etiology*; D004438:Ecchymosis / Q000209:etiology* / Q000276:immunology; D005130:Eye Hemorrhage / Q000209:etiology*; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000302:isolation & purification; D010314:Partial Thromboplastin Time
chemical_list: D007136:Immunoglobulins; C019158:circulating anticoagulants; D005169:Factor VIII
vernacular_title: Ecchymoses spontanées révélatrices d'un inhibiteur acquis du facteur VIII.