Identification of apparent dual ANCA specificities in a subset of patients with systemic vasculitis and crescentic glomerulonephritis.
23% of a random selection of ANCA (+) patients had dual, non-cross reactive autoantibody specificities. We found no clinical difference in such patients as compared to those having a single antibody. A second group of ANCA (+) patients had neither anti-MPO nor anti-PR3 autoantibody specificity. These findings suggest that multiple, coincident ANCA specificities occur more commonly than previously reported, and that additional, unidentified ANCA specificities are present in some patients.
Teeraratkul
P
P
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Thorson
J A
JA
Kemp
J D
JD
Goeken
J A
JA
D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D053146:Myeloblastin; D009195:Peroxidase / Q000276:immunology; D012697:Serine Endopeptidases / Q000276:immunology; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin