An Australian experience of transdermal oestradiol patches in a subtropical climate.
Tolerability and efficacy of transdermal oestradiol patches were assessed in 121 menopausal women over a period of 3 months to 2.5 years. Of particular interest, in a subtropical climate such as Brisbane, were the problems associated with adhesiveness and skin irritation during the summer months. We conducted a retrospective study with self-administered questionnaires. All patients had been selected for the nonoral route because of side-effects or relative contraindications to oral therapy. There was, overall, good efficacy and acceptability. The majority of the women found the patch very adequate in relieving symptoms of the menopause (vasomotor, genitourinary and musculoskeletal). Most preferred the patch to oral therapy. The oestradiol patch was well tolerated and few side-effects were reported. Breast tenderness and weight gain were 2 minor problems associated with its use. Skin irritation was minimal, but adhesiveness was a problem during the summer months, especially with swimming or showering. Some practical suggestions were obtained about how to overcome site of application problems.
O'Neill
S
S
Lilian Cooper Centre, Spring Hill, Queensland.
Kirkegard
Y
Y
D000268:Adhesiveness; D000279:Administration, Cutaneous; D017453:Dermatitis, Irritant / Q000209:etiology; D004958:Estradiol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause; D017060:Patient Satisfaction; D011793:Queensland; D012189:Retrospective Studies; D015983:Selection Bias; D014329:Tropical Climate
D004958:Estradiol