Unsaturated fat and low energy intake induce whereas an increment in energy intake ameliorates fatty liver during prolonged alcohol consumption by rats.
Two groups of rats were fed liquid diets containing 35% of energy as fat and either 36 or 26% of energy as alcohol to examine the effect of fat and energy intake on alcoholic fatty liver production. After 4 wk, five rats in each group were killed for analysis of liver triglyceride concentration, and then the alcohol diets fed to remaining rats were switched. All remaining rats were killed for hepatic triglyceride determination after another 4 wk. Rats initially fed the 36% alcohol diet or those switched to this diet ingested less energy, exhibited alcoholemia and slow growth, and developed fatty livers. Rats initially fed the 26% alcohol diet or those switched to this diet ingested significantly more energy, high amounts of alcohol and fat, exhibited low alcoholemia and faster growth than when they were fed the 36% alcohol diet. Fatty liver was absent in rats fed the 26% alcohol diet but was induced when they were fed the 36% alcohol diet. Fatty liver in rats initially fed the 36% alcohol diet regressed completely when the rats were switched to the 26% alcohol diet. Additional studies employing 36% alcohol diets containing 35% of energy as fat, derived from either corn oil or olive oil, revealed that unsaturated fat and not specifically linoleate plays a role in the induction of fatty liver. Thus, nutritional factors regulate the induction or regression of fatty liver and alcoholemia in alcoholic rats.
Sankaran
H
H
Surgical Service, Department of Veterans Affairs Medical Center, Portland, OR 97207.
Larkin
E C
EC
Rao
G A
GA
D000437:Alcoholism / Q000150:complications*; D000438:Alcohols / Q000097:blood; D000818:Animals; D003314:Corn Oil / Q000008:administration & dosage; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D002149:Energy Intake; D005235:Fatty Liver, Alcoholic / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000096:biosynthesis; D015430:Weight Gain / Q000187:drug effects
D000438:Alcohols; D004042:Dietary Fats, Unsaturated; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; D003314:Corn Oil