Design and synthesis of inhibitors of folate-dependent enzymes as antitumor agents.
Taylor
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Department of Chemistry, Princeton University, New Jersey 08544.
D000217:Acyltransferases / Q000037:antagonists & inhibitors; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D015195:Drug Design; D005492:Folic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000633:toxicity; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D005971:Glutamates / Q000138:chemical synthesis; D006147:Guanine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D006801:Humans; D019877:Hydroxymethyl and Formyl Transferases; D007202:Indicators and Reagents; D015394:Molecular Structure; D000068437:Pemetrexed; D051026:Phosphoribosylglycinamide Formyltransferase; D011758:Pyrroles; D011799:Quinazolines / Q000138:chemical synthesis / Q000633:toxicity; D013329:Structure-Activity Relationship; D013763:Tetrahydrofolates / Q000138:chemical synthesis
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D005971:Glutamates; D007202:Indicators and Reagents; D011758:Pyrroles; D011799:Quinazolines; D013763:Tetrahydrofolates; D000068437:Pemetrexed; D006147:Guanine; C045894:lometrexol; C031662:CB 3717; D005492:Folic Acid; D019877:Hydroxymethyl and Formyl Transferases; D051026:Phosphoribosylglycinamide Formyltransferase; D000217:Acyltransferases