Treatment of non-tuberculous mycobacterial infections in patients without AIDS.
This report summarizes the results of an 8-year study of the treatment of non-tuberculous mycobacterial infections and the long-term efficacy of this treatment in patients without AIDS. Of 25 patients, aged 10-82 years, 24 had pulmonary involvement; in 5 cases as part of disseminated disease. One patient had a renal infection only. Predisposing factors were identified in 16 patients. M. avium-intracellulare and M. malmoense were isolated in 17 and 7 patients, respectively, and M. kansasii in 1 patient. Three patients were subjected to lobectomy and 22 received multiple drug chemotherapy for 18-60 months. Chemotherapy was initially effective in 17/22 patients and surgery in 3/3. However, in the end 10 patients died of their mycobacterial infection, and 6 are still suffering from chronic infection. Only 7 patients appear to be free of disease more than 2 years after completing chemotherapy.
Heurlin
N
N
Department of Respiratory and Allergic Diseases, Huddinge University Hospital, Sweden.
Petrini
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000617:Aminoglycosides / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000188:drug therapy* / Q000401:mortality; D017828:Rifabutin / Q000627:therapeutic use; D016896:Treatment Outcome
D000617:Aminoglycosides; D000904:Antibiotics, Antitubercular; D017828:Rifabutin; D004977:Ethambutol