FR901459, a novel immunosuppressant isolated from Stachybotrys chartarum No. 19392. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities.
FR901459, a novel immunosuppressant, has been isolated from the fermentation broth of Stachybotrys chartarum No. 19392. The molecular formula of FR901459 was determined as C62H111N11O13. FR901459 was found to be a member of the cyclosporin family. However, it is structurally distinct from any other cyclosporins discovered so far, in that Leu is present at position 5 instead of Val. FR901459 was capable of prolonging the survival time of skin allografts in rats with one third the potency of cyclosporin A.
Sakamoto
K
K
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Tsujii
E
E
Miyauchi
M
M
Nakanishi
T
T
Yamashita
M
M
Shigematsu
N
N
Tada
T
T
Izumi
S
S
Okuhara
M
M
D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016572:Cyclosporine / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D005656:Fungal Proteins / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013191:Stachybotrys / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*
D005656:Fungal Proteins; D007166:Immunosuppressive Agents; C085611:FR 901459; D016572:Cyclosporine