[The protective action of glycyrrhiza flavonoids against carbon tetrachloride hepatotoxicity in mice].
The protective action of Glycyrrhiza flavonoids (GF), the major components in the radix of Glycyrrhiza, on carbon tetrachloride-induced hepatotoxicity was investigated. The carbon tetrachloride-induced increases of serum glutamic-pyruvic transaminase and lactate dehydrogenase were significantly inhibited by GF dose-dependently. Carbon tetrachloride-induced necrosis in mice were ameliorated by GF pretreatment. Concomitantly, the carbon tetrachloride-induced elevation of MDA in the liver was lowered by GF. GF neither reduced the activities of the two enzymes in normal mouse sera nor directly inhibited the activities of the two enzymes in the serum. These findings suggest that the anti-lipid peroxidation effect of GF was contributed to its protective action against carbon tetrachloride-induced hepatotoxicity.
Wang
G S
GS
Department of Pharmacology, Inner Mongolia Medical College, Huhhot.
Han
Z W
ZW
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D006035:Glycyrrhiza / Q000737:chemistry; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010946:Plants, Medicinal
D005419:Flavonoids; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D005978:Glutathione