The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21.
The last step in the biosynthesis of Le(x) antigen, the addition of a fucose to precursor polysaccharides, can be catalyzed by different alpha-3-fucosyltransferases. We localized the gene (FUT4) encoding myeloid alpha-3-fucosyltransferase by PCR assay using panels of somatic cell and radiation hybrids which retain different rearrangements of chromosome 11. FUT4 was assigned to chromosome band 11q21 between D11S388 and D11S919.
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INSERM U178, Villejuif, France.
James
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MR
Richard
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CW
Mollicone
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Seawright
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Lowe
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JB
Oriol
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Couillin
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D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006224:Cricetinae; D004247:DNA; D015342:DNA Probes; D005647:Fucosyltransferases / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D015342:DNA Probes; D004247:DNA; D005647:Fucosyltransferases; C031692:galactoside 3-fucosyltransferase