title: A pharmacokinetic interaction between cimetidine or ranitidine and lornoxicam.
abstract: Cimetidine 400 mg twice daily significantly increased serum concentrations and reduced apparent oral clearance of lornoxicam 8 mg twice daily in 12 healthy volunteers. Ranitidine 150 mg twice daily produced no significant changes in lornoxicam pharmacokinetics.
authors.affiliation: Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Ravic
authors.forename: I
authors.initials: I
authors.lastname: Salas-Herrera
authors.forename: A
authors.initials: A
authors.lastname: Johnston
authors.forename: P
authors.initials: P
authors.lastname: Turner
authors.forename: K
authors.initials: K
authors.lastname: Foley
authors.forename: D E
authors.initials: DE
authors.lastname: Rosenow
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D002927:Cimetidine / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011899:Ranitidine / Q000493:pharmacokinetics*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D002927:Cimetidine; D011899:Ranitidine; C059451:lornoxicam