title: Renal abnormalities in leprosy.
abstract: We have evaluated laboratory and clinical manifestations of renal disease in 96 patients with leprosy, looking for a sensitive and early marker for detection and possibly follow-up of nephropathy in these patients. Microscopic hematuria was observed in 21.9% of the cases (with dysmorphic erythrocytes in 71.4% of them). Abnormal microalbuminuria and urinary beta 2-microglobulin were found in 15.8 and 19.8% of the cases, respectively. We have observed a high frequency of hematuria, abnormal microalbuminuria and elevation of urinary beta 2-microglobulin in these patients still with normal serum creatinine.
authors.affiliation: Department of Medicine, Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: G M
authors.initials: GM
authors.lastname: Kirsztajn
authors.forename: S K
authors.initials: SK
authors.lastname: Nishida
authors.forename: M S
authors.initials: MS
authors.lastname: Silva
authors.forename: H
authors.initials: H
authors.lastname: Ajzen
authors.forename: A B
authors.initials: AB
authors.lastname: Pereira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000209:etiology; D015415:Biomarkers / Q000652:urine; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology* / Q000652:urine; D007918:Leprosy / Q000097:blood / Q000150:complications* / Q000652:urine; D008297:Male; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin; D003404:Creatinine