Cutaneous exposure to warfarin-like anticoagulant causing an intracerebral hemorrhage: a case report.
A case of intercerebral hematoma due to warfarin-induced coagulopathy is presented. The 39-year-old woman had spread a warfarin-type rat poison around her house weekly using her bare hands, with no washing post application. Percutaneous absorption of warfarin causing coagulopathy, reported three times in the past, is a significant risk if protective measures, such as gloves, are not used. An adverse drug interaction with piroxicam, which she took occasionally, may have exacerbated the coagulopathy.
Abell
T L
TL
University of Tennessee, Memphis.
Merigian
K S
KS
Lee
J M
JM
Holbert
J M
JM
McCall
J W
JW
D000279:Administration, Cutaneous; D000328:Adult; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D010894:Piroxicam / Q000494:pharmacology; D011041:Poisoning / Q000175:diagnosis / Q000628:therapy; D012378:Rodenticides / Q000008:administration & dosage / Q000506:poisoning*; D014859:Warfarin / Q000008:administration & dosage / Q000506:poisoning*
D012378:Rodenticides; D010894:Piroxicam; D014859:Warfarin