[Effective regimen for eradication of Helicobacter pylori].
There is now substantial evidence that Helicobacter pylori (H. pylori) is both a frequent cause of chronic gastritis and an important factor in the recurrence of duodenal ulcer. However, to achieve the eradication of H. pylori is very difficult and although a number of treatment regimens suppress this organism, the stomach usually becomes recolonized shortly after the cessation of treatment. Many reports have shown that polytherapy is more effective than monotherapy. And so, the best results have been achieved with triple therapy using combination of bismuth, metronidazole, or tinidazole, and amoxicillin or tetracycline. The factor influencing effectiveness of triple therapy is compliance with the prescribed medications. And so, short term triple therapy is highly effective and well tolerated.
Nakashima
T
T
Second Department of Internal Medicine, Kobe University School of Medicine.
Morimoto
S
S
Ohmoto
A
A
Aoyama
N
N
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001729:Bismuth / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans
D000900:Anti-Bacterial Agents; C010804:bismuth subnitrate; D001729:Bismuth