Niacin-induced hepatotoxicity: unusual presentations.
We report four cases of niacin-induced hepatotoxicity. All four patients were using sustained-release niacin preparations. When they stopped taking niacin, symptoms and laboratory abnormalities resolved. Two of the patients had focal fatty infiltration of the liver on imaging studies, a presentation of niacin hepatotoxicity not previously described. One patient had a coagulopathy even though aminotransferase levels were only mildly elevated. We recommend that patients using sustained-release preparations of niacin have periodic monitoring of liver enzymes and that the preparation be discontinued if any abnormalities develop.
Coppola
A
A
Department of Medicine, University of South Florida College of Medicine, Tampa.
Brady
P G
PG
Nord
H J
HJ
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000009:adverse effects*
D003692:Delayed-Action Preparations; D009525:Niacin