title: [Congenital candida infections].
abstract: Congenital candida infection is a rare disease, although the incidence of candida vaginitis during pregnancy is high. We report on five cases each showing patterns considered typical for candida infection. The infective agent can cause chorioamnionitis even in the presence of intact fetal membranes. An intrauterine device (IUD) has been proved to be a risk factor for a congenital candida infection. The pathogenetic significance of contamination with candida for the fetus appears to depend largely on gestational age. A premature infant with a birth-weight less than 1500 g presented with bilateral candida endophthalmitis which was cured by intravenous Fluconazole therapy. Another premature infant weighing 800 g at birth developed a systemic candida infection. The other three more mature infants had milder symptoms, two of them presented with cutaneous candidiasis.
authors.affiliation: Abteilung Neonatologie, Johann-Wolfgang-Goethe-Universität, Frankfurt/Main.
authors.forename: R L
authors.initials: RL
authors.lastname: Schlösser
authors.forename: A
authors.initials: A
authors.lastname: Zubcov
authors.forename: M
authors.initials: M
authors.lastname: Bollinger
authors.forename: M
authors.initials: M
authors.lastname: Kühnert
authors.forename: V
authors.initials: V
authors.lastname: Loewenich
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000666:Amphotericin B / Q000008:administration & dosage; D002177:Candidiasis / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D002179:Candidiasis, Cutaneous / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy; D002180:Candidiasis, Oral / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy; D002181:Candidiasis, Vulvovaginal / Q000175:diagnosis / Q000188:drug therapy; D002821:Chorioamnionitis / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D009761:Nystatin / Q000008:administration & dosage; D011247:Pregnancy
chemical_list: D009761:Nystatin; D000666:Amphotericin B; D005437:Flucytosine
vernacular_title: Kongenitale Candidainfektionen.