Comparison of parathyroid donor grafts.
We compared the degrees of cell maturity, antigenicity and secretory function of parathyroid tissues (PTG) from cadavers (C-PTG), 20-28 week fetuses (F-PTG) and PTG adenomas (A-PTG). In A-PTG, scattered or clustered immature cells were observed, but there were none in F-PTG and C-PTG tissues. A-PTG and C-PTG exhibited better secretory function than did F-PTG. No clear differences were found in HLA class I (ABC) antigen quantity among the three donor PTG tissues, but the amounts of HLA class II (DR) antigen in A-PTG and F-PTG were significantly lower than that in C-PTG. The results demonstrate that C-PTG, with its functional advantages, and F-PTG, with its relatively low antigenicity, can be used in clinical transplantation, while A-PTG tissues are not suitable for clinical transplantation on account of their immaturity and the possibility of carcinomatous change.
Gao
Z
Z
PUMC Hospital, CAMS, Beijing.
Zhu
Y
Y
Tang
W
W
D000236:Adenoma / Q000276:immunology / Q000473:pathology; D016332:Fetal Tissue Transplantation; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D010280:Parathyroid Glands / Q000276:immunology / Q000378:metabolism / Q000637:transplantation; D010282:Parathyroid Neoplasms / Q000276:immunology / Q000473:pathology; D014019:Tissue Donors
D006684:HLA-DR Antigens