[Mechanisms of electrogenic secretion of potassium in endolymph].
Endolymphatic potential is assumed to result from active K transport into the endolymphatic compartment and passive K diffusion in the opposite direction. However, in several in vivo experiments, changes in endolymphatic potential differed from that in endolymphatic K concentration. Moreover, in in vitro experiments, a negative endolymphatic potential was observed in presence of ouabain without K gradient between the two compartments. These observations suggest that the coupling between the K transport and the genesis of the endolymphatic potential is not tight. Several factors may influence separately the endolymphatic potential and the K transport such as the acid-base equilibrium, the integrity of the Reissner's membrane, the hormonal status and the Na transport.
Ferrary
E
E
INSERM U. 251, Faculté Xavier Bichat, Université Paris 7, France.
Bernard
C
C
Julien
N
N
Sterkers
O
O
Amiel
C
C
D004710:Endolymph / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000032:analysis / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism
D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
Mécanismes de la sécrétion électrogène de potassium dans l'endolymphe.