title: Enhanced detection of brain tumors by [18F]fluorodeoxyglucose PET with glucose loading.
abstract: OBJECTIVE
  We applied glucose loading during PET studies with [18F]2-fluoro-2-deoxy-D-glucose (FDG) to enhance detection of brain tumors by diminution of FDG uptake in normal gray matter.
  
  
  METHODS
  This study involved three patients with glioblastomas. Two PET scans were performed in all cases within 1 week in control and with glucose loading state.
  
  
  RESULTS
  In all patients, tumor was depicted more clearly with glucose loading than in the control study. The FDG uptake ratio of tumor to normal cortical gray matter showed a mean increase of 27% with glucose loading.
  
  
  CONCLUSIONS
  This technique might be useful for detection of recurrent or residual tumors.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishizu
authors.forename: N
authors.initials: N
authors.lastname: Sadato
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekura
authors.forename: S
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Magata
authors.forename: N
authors.initials: N
authors.lastname: Tamaki
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: H
authors.initials: H
authors.lastname: Okazawa
authors.forename: F
authors.initials: F
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Miyatake
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose