title: [Establishment of a human lung squamous cell carcinoma cell line LK-17, and characterization of procoagulant, platelet aggregation and metastatic potential].
abstract: A squamous cell carcinoma cell line LK-17 was established from original surgical specimen of the lung. Doubling time of LK-17 in vitro is 43.2 hours, and chromosome analysis shows various abnormality and main modeat 62. LK-17 shows stable metastatic potential to the lung of nude mouse when injected i.v. LK-17 cells show platelet aggregating activity with number population dependent manner. LK-17 secretes direct factor X activating procoagulant which differs from those of tissue factor, cystein protease A and coagulant cancer antigen 1. These platelet aggregation potential and procoagulant activity may play a important roll in metastatic process.
authors.affiliation: Department of Surgery, Torigata Hospital, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Inufusa
authors.forename: T
authors.initials: T
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: N
authors.initials: N
authors.lastname: Sagara
authors.forename: M
authors.initials: M
authors.lastname: Yasutomi
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D005170:Factor X / Q000378:metabolism; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D010974:Platelet Aggregation; D012697:Serine Endopeptidases / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D005170:Factor X; D012697:Serine Endopeptidases