Effects of clonidine on desipramine- and desmethylclomipramine-induced 3-methoxy-4-hydroxyphenylglycol levels in rat brain.
Rats received repeated i.p. administrations of desipramine (20 mg/kg) or desmethylclomipramine (10 mg/kg). The steady state concentration of each drug in the brain was attained a few days after the start of the treatment. The treatments with desipramine and desmethylclomipramine for more than 10 and 2 days, respectively, induced significant elevation of 3-methoxy-4-hydroxyphenylglycol (MHPG) level in the brain. After repeated administration of each drug, rats were given a single i.p. injection of clonidine (50 micrograms/kg). This treatment decreased the elevated MHPG level in the brain of desmethylclomipramine-treated rats, whereas it had no effect on the increased MHPG level in desipramine-treated rats.
Fujita
K
K
Department of Neuropsychiatry, Aichi Medical College, Japan.
Iijima
N
N
Suzuki
S
S
Nakazawa
K
K
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
C012273:desmethylclomipramine; D008734:Methoxyhydroxyphenylglycol; D003000:Clonidine; D002997:Clomipramine; D003891:Desipramine; D009638:Norepinephrine