Little evidence for anti-endothelial-cell antibodies in microscopic polyarteritis and Wegener's granulomatosis.
Sera from patients with a vasculitis and controls were investigated for the presence of anti-endothelial cell antibodies(AECA), anti- neutrophil cytoplasmic antibodies(ANCA) and anti-myeloperoxidase (MPO) antibodies. Only 19% of patients with Wegener's granulomatosis and 2% of patients with microscopic polyarteritis had AECA. Our data suggests that AECA are a minor antibody system in vasculitis.
Varagunam
M
M
Renal Research Laboratory, Queen Elizabeth Hospital, Edgbaston, Birmingham.
Nwosu
A C
AC
Adu
D
D
Garner
C
C
Taylor
C M
CM
Michael
J
J
Thompson
R A
RA
D019268:Antibodies, Antineutrophil Cytoplasmic; D001167:Arteritis / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D009195:Peroxidase / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009195:Peroxidase