Acute effects of insulin-like growth factor-I (IGF-I) on bone protein synthesis in rats.
The acute systemic effects of IGF-I on bone protein metabolism from hormonally intact rats have been investigated by measuring the fractional rate of protein synthesis. The animals received a single subcutaneous injection of rhIGF-I (100 micrograms). Treatment with IGF-I increased the rate of tibia protein synthesis (Ks) while plasma glucose and insulin concentrations were decreased. These results are in favor of an endocrine role of IGF in stimulating bone growth.
Martínez
A J
AJ
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
Pascual
M
M
Larralde
J
J
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001846:Bone Development / Q000187:drug effects*; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D010649:Phenylalanine; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000187:drug effects* / Q000378:metabolism; D014316:Tritium
D001786:Blood Glucose; D007328:Insulin; D014316:Tritium; D010649:Phenylalanine; D007334:Insulin-Like Growth Factor I