The effect of high sodium intake on bone mineral content in rats fed a normal calcium or a low calcium diet.
The effect of high sodium intake on bone mineral content of rats fed a normal (0.6% Ca) or a low (0.02% Ca) calcium diet was studied. Rats on a normal calcium diet given 1.8% sodium chloride to drink showed persistent and significant hypercalciuria and subnormal bone mineral content. Total calcium content of femur was significantly lower after 4 months (p < 0.02) and 12 months (p < 0.001). In rats maintained on a low calcium diet (0.02% Ca), a high sodium diet for 8 weeks caused a significant loss of calcium in bone similar to that seen in animals fed a normal calcium diet for 4 months. We conclude that high sodium intake reduces bone mineral content, especially if the diet is low in calcium.
Chan
A Y
AY
Department of Chemical Pathology, Prince of Wales Hospital, Shatin NT, Hong Kong, UK.
Poon
P
P
Chan
E L
EL
Fung
S L
SL
Swaminathan
R
R
D000818:Animals; D015519:Bone Density; D002118:Calcium / Q000378:metabolism / Q000652:urine; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D005269:Femur / Q000378:metabolism; D008297:Male; D009318:Natriuresis; D010710:Phosphates / Q000378:metabolism / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012982:Sodium, Dietary / Q000008:administration & dosage*
D002136:Calcium, Dietary; D010710:Phosphates; D012982:Sodium, Dietary; D002118:Calcium