title: Correlation between DNA ploidy and clinical features in smooth muscle tumors of the gastrointestinal tract.
abstract: Paraffin-embedded tissue samples from 51 surgically resected, gastrointestinal smooth muscle tumors (10 leiomyomas, 5 leiomyoblastomas and 36 leiomyosarcomas) were assayed for nuclear DNA content, and the results were examined for correlation with clinico-pathological variables (tumor size, cellularity and mitosis) and prognosis. Twenty-four (47%) of the 51 tumors, consisting of 3 (30%) of the 10 leiomyomas, 2 (40%) of the 5 leiomyoblastomas and 19 (53%) of the 36 leiomyosarcomas, were identified as aneuploid. A close correlation was found between the mitotic index and the tumor size (<cc> = 0.528; P < 0.001). The DNA ploidy pattern of the leiomyosarcoma was closely correlated with the patient survival periods (P = 0.06). The estimated median survival period was 73 months for patients with diploid tumors, and 51 months for those with aneuploid tumors. The 10-year survival rate for aneuploid tumors was lower than that for diploid tumors (P < 0.001). The measurement of DNA content may provide an index of prognostic value in gastrointestinal leiomyosarcomas.
authors.affiliation: Department of Surgery II, School of Medicine, Kanazawa University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Yonemura
authors.forename: N
authors.initials: N
authors.lastname: Kadoya
authors.forename: T
authors.initials: T
authors.lastname: Kosaka
authors.forename: K
authors.initials: K
authors.lastname: Miwa
authors.forename: I
authors.initials: I
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Sawa
authors.forename: S
authors.initials: S
authors.lastname: Yoshimitsu
authors.forename: Y
authors.initials: Y
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Kamata
mesh_terms: D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007889:Leiomyoma / Q000235:genetics / Q000473:pathology; D018230:Leiomyoma, Epithelioid / Q000235:genetics / Q000473:pathology; D007890:Leiomyosarcoma / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth; D011003:Ploidies
chemical_list: D004273:DNA, Neoplasm