title: Serum LpAI lipoprotein particles in diabetic patients with and without renal lesions of different grades.
abstract: Among high density lipoprotein particles, LpAI particles which contain apolipoprotein A1 alone, appear to be involved in cholesterol transport from peripheral tissues to the liver. The aim of this cross-sectional study was to examine serum LpAI particle concentrations in Type 1 and Type 2 diabetic patients with renal lesions of differing grades, in comparison with normal controls and with nondiabetic patients presenting with chronic renal failure. LpAI concentrations and LpAI-to-apo A1 ratios were increased in Type 1 diabetic patients with normal albumin excretion. In Type 1 and in Type 2 diabetic patients with increased urinary albumin excretion, LpAI concentrations and LpAI-to-apo A1 ratios were found to be not different from those of normal controls. In diabetic and in nondiabetic patients with chronic renal failure, LpAI concentrations were decreased. These abnormalities may contribute to the development of macrovascular complications.
authors.affiliation: Laboratoire de Biochimie, Hôpital Lariboisière, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Peynet
authors.forename: P J
authors.initials: PJ
authors.lastname: Guillausseau
authors.forename: A
authors.initials: A
authors.lastname: Legrand
authors.forename: J J
authors.initials: JJ
authors.lastname: Altman
authors.forename: F
authors.initials: F
authors.lastname: Flourie
authors.forename: P
authors.initials: P
authors.lastname: Chanson
authors.forename: J
authors.initials: J
authors.lastname: Poupon
authors.forename: M
authors.initials: M
authors.lastname: N'Guyen
authors.forename: A
authors.initials: A
authors.lastname: Warnet
authors.forename: J
authors.initials: J
authors.lastname: Lubetzki
mesh_terms: D000328:Adult; D000419:Albuminuria; D016632:Apolipoprotein A-I / Q000032:analysis / Q000378:metabolism*; D001053:Apolipoproteins / Q000032:analysis / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000652:urine; D003929:Diabetic Neuropathies / Q000097:blood* / Q000652:urine; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D017270:Lipoprotein(a) / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D017270:Lipoprotein(a); D014280:Triglycerides; C078260:lipoprotein A-I