[Association of rheumatoid arthritis and Kaposi disease. Apropos of a case arising after intraarticular corticotherapy].
A 66 year old Corsican HLA A2 and DR5-positive male with moderately active seropositive destructive rheumatoid arthritis developed Kaposi's sarcoma after intraarticular administration of corticosteroids. He had no history of oral corticosteroid therapy, organ transplantation, AIDS, or cancer. Chlorambucil proved ineffective but the outcome was spontaneously favorable following discontinuation of oral corticosteroid therapy initiated after the development of the skin lesions. Six previous reports of concomitant rheumatoid arthritis and Kaposi's sarcoma were found. All six cases occurred following systemic corticosteroid therapy. The high incidence of rheumatoid arthritis and the small number of patients with rheumatoid arthritis and Kaposi's sarcoma suggest that concomitant occurrence of the two conditions may be fortuitous. However, the responsibility of corticosteroid therapy, which preceded development of Kaposi's sarcoma in every case, cannot be ruled out.
Azais
I
I
Service de Rhumatologie, CHRU Poitiers.
Lambert de Cursay
G
G
Deblais
F
F
Deschamps
O
O
Gandon
P
P
Alcalay
M
M
Bontoux
D
D
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D002699:Chlorambucil / Q000627:therapeutic use; D006801:Humans; D007109:Immunity; D007270:Injections, Intra-Articular / Q000009:adverse effects; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D012514:Sarcoma, Kaposi / Q000139:chemically induced*; D014983:Xeroderma Pigmentosum / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
D002699:Chlorambucil; D011239:Prednisolone
Association polyarthrite rhumatoïde--maladie de Kaposi. A propos d'un cas survenant au décours d'une corticothérapie intra-articulaire.