title: Re-freeze dried bilayer artificial skin.
abstract: A bilayer artificial skin composed of a silicone sheet and a collagen sponge sheet was developed by us in 1986, modifying Yannas and Burke's technique. It was used in experimental animals and clinically, both with success; but the artificial skin was inconvenient for clinical use in terms of disinfection and preservation. In an attempt to reduce the drawbacks, we developed a re-freeze dried artificial skin. Experiments were conducted to examine whether the re-freeze dried material is equivalent to the prototype one. A significant difference between the two was found in tensile tests but not in experimental and clinical effects.
authors.affiliation: Department of Plastic Surgery, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Isshiki
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D000328:Adult; D000818:Animals; D003094:Collagen / Q000737:chemistry; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D012828:Silicones / Q000737:chemistry; D012867:Skin / Q000648:ultrastructure; D017768:Skin, Artificial; D013718:Tensile Strength; D014021:Tissue Preservation
chemical_list: D012828:Silicones; D003094:Collagen