title: Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents.
authors.affiliation: ZENECA Pharmaceuticals, Macclesfield, Cheshire, UK.
authors.forename: F T
authors.initials: FT
authors.lastname: Boyle
authors.forename: Z S
authors.initials: ZS
authors.lastname: Matusiak
authors.forename: L R
authors.initials: LR
authors.lastname: Hughes
authors.forename: A M
authors.initials: AM
authors.lastname: Slater
authors.forename: T C
authors.initials: TC
authors.lastname: Stephens
authors.forename: M N
authors.initials: MN
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: R
authors.initials: R
authors.lastname: Kimbell
authors.forename: A L
authors.initials: AL
authors.lastname: Jackman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000201:enzymology; D051379:Mice; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D005492:Folic Acid; D013940:Thymidylate Synthase; C059966:ICI 198583