The effect of prostaglandin E1 analog misoprostol on chronic cyclosporin nephrotoxicity.
Cyclosporin A has markedly improved graft survival in transplant patients but its side effects, such as renal toxicity and hypertension, pose management problems in transplant recipients. This toxicity has been attributed to prostaglandin inhibition. Concurrent administration of misoprostol (a prostaglandin E1 analog) prevents chronic cyclosporin A-induced nephrotoxicity but not hypertension in rats.
John
E G
EG
Division of Pediatric Nephrology, University of Illinois, Chicago.
Fornell
L C
LC
Radhakrishnan
J
J
Anutrakulchai
S
S
Jonasson
O
O
D000450:Aldosterone / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004573:Electrolytes / Q000097:blood; D005919:Glomerular Filtration Rate; D006339:Heart Rate; D006973:Hypertension / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D016595:Misoprostol / Q000494:pharmacology / Q000627:therapeutic use*; D009994:Osmolar Concentration; D011453:Prostaglandins / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation; D012083:Renin / Q000097:blood
D004573:Electrolytes; D011453:Prostaglandins; D016595:Misoprostol; D000450:Aldosterone; D016572:Cyclosporine; D009320:Atrial Natriuretic Factor; D003404:Creatinine; D012083:Renin