[The use of preparations of methazid combined with riboflavin and pyridoxine for the correction of methazid-induced metabolic disorders of the B-group vitamins in rats].
It was established that 10-day administration of suppository methazide (20 mg per 100 g b. w.) induces B2 vitamin deficiency indicated by relevant hepatic and plasmic values. In vitamin B2 deficiency methazide-induced changes in vitamin B6 metabolism are less marked in rats provided with riboflavin. Use of suppository methazide in combination with riboflavin (100 micrograms per animal which is a recommended daily dose) prevents B2 deficiency. It is recommended daily use combinations of methazide with riboflavin or piridoxin in essential daily consumption doses to treat patients with alimentary vitamin B2 and B6 deficiencies. This will not only prevent side effects of methazide, but also help to overcome deficiency of the above vitamins.
Kovalenko
T A
TA
Kodentsova
V M
VM
Sokol'nikov
A A
AA
Iakushina
L M
LM
Kharitonchik
L A
LA
Sonin
B V
BV
Stroev
E A
EA
D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D011736:Pyridoxine / Q000008:administration & dosage*; D051381:Rats; D012256:Riboflavin / Q000008:administration & dosage*; D012257:Riboflavin Deficiency / Q000188:drug therapy / Q000378:metabolism; D013488:Suppositories; D026681:Vitamin B 6 Deficiency / Q000188:drug therapy / Q000378:metabolism; D014803:Vitamin B Complex / Q000032:analysis / Q000378:metabolism*
D004338:Drug Combinations; D013488:Suppositories; D014803:Vitamin B Complex; C100205:methazid; D011736:Pyridoxine; D012256:Riboflavin; D007538:Isoniazid
Ispol'zovanie kombinirovannykh preparatov metazida s riboflavinom i piridoksinom dlia korrektsii metazidindutsiruemykh narusheniĭ obmena vitaminov gruppy B u krys.