title: Transient thiol-expression and thiol disulphide cluster-receptor communications: a molecular basis for blastocyst-uterine interactions during implantation.
abstract: The attachment of trophoblast to uterine epithelium during implantation is an intricate and complex instance of cell-cell communication, the molecular aspects of which remain rather undefined. In this study, we screened the surface domains of the pre-, peri- and post implantation mouse embryos with a thiol-specific probe. Transient thiol-expression in peri-implantation embryos suggested their involvement in implantation either through disulphide bridge establishment or through a communication between a thiol-disulphide cluster of the blastocyst and a corresponding receptor of the endometrium.
authors.affiliation: School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India.
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: G P
authors.initials: GP
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Laloraya
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000502:physiology*; D002450:Cell Communication; D004220:Disulfides / Q000378:metabolism*; D010064:Embryo Implantation / Q000502:physiology*; D004848:Epithelium / Q000502:physiology; D005260:Female; D005452:Fluoresceins; D005456:Fluorescent Dyes; D051379:Mice; D008815:Mice, Inbred Strains; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D014599:Uterus / Q000166:cytology / Q000502:physiology*
chemical_list: D004220:Disulfides; D005452:Fluoresceins; D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds; C015296:5-iodoacetamidofluorescein