title: [The clinico-pathogenetic aspects of sex dimorphism in gout].
abstract: The examination of 241 gout patients (207 males and 34 females) revealed a marked sexual dimorphism of the disease related to the articular and renal syndromes. Male gout is characterized by higher blood levels of uric acid and oxypurinole in reduced clearance of the latter, while in female gout there were hyperxanthinoxidasemia and hypo-cAMPemia. Unbalance of sex and gonadotropic hormones, which appeared multidirectional and dependent on the sex, was observed in males in the form of lower concentrations of blood testosterone and estradiol against elevated levels of progesterone and lutropin, in females manifested with hypoprogesteronemia and reduced gonadotropin.
authors.forename: O V
authors.initials: OV
authors.lastname: Siniachenko
authors.forename: E N
authors.initials: EN
authors.lastname: Kosheleva
authors.forename: I V
authors.initials: IV
authors.lastname: Mukhin
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Siniachenko
authors.forename: L I
authors.initials: LI
authors.lastname: Tkachenko
authors.forename: V A
authors.initials: VA
authors.lastname: Tolstoĭ
mesh_terms: D015210:Arthritis, Gouty / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006073:Gout / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D012727:Sex Characteristics
chemical_list: D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D009712:Nucleotides, Cyclic; D011687:Purines
vernacular_title: Kliniko-patogeneticheskie aspekty polovogo dimorfizma pri podagre.