title: Angiotensin II and fluid ingestion in old rats.
abstract: Fluid ingestion was studied in Fischer 344/Brown Norway F1 rats aged 3, 12, 20, and 24 months of age. There was an age-related decrease in fluid ingestion when fluid intake was measured over 24 h. After water deprivation, 24- and 20-month-old rats drank less than 3- and 12-month-old rats. Twelve, 20-, and 24-month-old rats had less fluid intake associated with food deprivation than did 3-month-old rats. Three month old rats drank more fluid after angiotensin II than did 12-, 20-, and 24-month-old rats when expressed as fluid intake per kg body weight. These studies confirm that the rat is a reasonable model to study age-related hypodipsia.
authors.affiliation: Education and Clinical Center, St. Louis Department of Veterans Affairs, MO 63104.
authors.forename: A J
authors.initials: AJ
authors.lastname: Silver
authors.forename: J E
authors.initials: JE
authors.lastname: Morley
authors.forename: T V
authors.initials: TV
authors.lastname: Ishimaru-Tseng
authors.forename: P M
authors.initials: PM
authors.lastname: Morley
mesh_terms: D000375:Aging / Q000523:psychology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D005508:Food Deprivation; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D014868:Water Deprivation
chemical_list: D000804:Angiotensin II