title: Alpha-1-antitrypsin, CRP and interleukin-6 in ANCA-positive vasculitis.
abstract: Alfa-1-antitrypsin (a-1-AT), C-reactive protein (CRP) and interleukin-6 (IL-6) serum levels were measured during different phases of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis. Correlation between ANCA and these variables was observed. Both a-1-AT and CRP fluctuations indicated changes in activity that could not always be detected by ANCA. On the other hand, these acute phase proteins were also less specific. IL-6 was not as sensitive as CRP and a-1-AT, a clearly increased mean value was observed only in patients with high ANCA titers.
authors.affiliation: IV Department of Medicine, University of Helsinki, Finland.
authors.forename: C
authors.initials: C
authors.lastname: Grönhagen-Riska
authors.forename: A M
authors.initials: AM
authors.lastname: Teppo
authors.forename: E
authors.initials: E
authors.lastname: Honkanen
authors.forename: R
authors.initials: R
authors.lastname: Ikäheimo
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D015850:Interleukin-6 / Q000378:metabolism*; D014657:Vasculitis / Q000097:blood* / Q000276:immunology; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; D015850:Interleukin-6; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein