[The hypoazotemic and diuretic action of lespeflan in acute kidney failure].
Hypoazotemic and diuretic effects of a new bioflavonoid drug lespephlan made in Russia have been tested in a dose 2 ml/kg to treat acute renal failure induced by mercury bichloride solution (a dose 2 mg/kg). The data were obtained on lespephlan ability to reduce blood levels of urea, creatinine and activate their renal elimination, to enhance diuresis, sodium clearance, glomerular filtration. Water and electrolyte release were also changeable by angiotensin aldosterone system. Mechanism of lespephlan hypoazotemic action is related to hepatic arginase inhibited activity as this enzyme plays a key role in detoxication of nitrous products urea and creatinine.
Guliaev
V G
VG
Ivanov
Iu I
IuI
Guliaeva
S F
SF
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000627:therapeutic use*; D006027:Glycosides / Q000627:therapeutic use*; D008627:Mercuric Chloride; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014511:Uremia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D004232:Diuretics; D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts; C085745:lespeflan; D008627:Mercuric Chloride
Gipoazotemicheskoe i dureticheskoe deĭstvie lespefalana pri ostroĭ pochechnoĭ nedostatochnosti.