[Effect of the complexes tocopherol-protein-acceptors and tocopherylquinone-protein-acceptors on the activity cytosol phospholipase A2 in rat liver].
A new method of tocopherol and tocopherylquinone binding with rat liver cytosol proteins-acceptors. Complexes tocopherol-proteins-acceptors and tocopheryl-quinone-proteins acceptors have been studied for their effect on phospholipase A2 activity. It is established that the both complexes are the inhibitors of phospholipase A2, under these conditions tocopherylquinone complex with proteins-acceptors more intensively decreases Km of the enzyme than the complex tocopherol-proteins-acceptors.
Parkhomets
V P
VP
Donchenko
G V
GV
Palivoda
O M
OM
D000818:Animals; D003600:Cytosol / Q000201:enzymology*; D004579:Electron Transport; D007700:Kinetics; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011506:Proteins / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
D011506:Proteins; D014810:Vitamin E; C002421:tocopherylquinone; D010741:Phospholipases A; D054467:Phospholipases A2
Vliianie kompleksov tokoferol-belki-aktseptory i tokoferilkhinon-belki-aktseptori na aktivnost' fosfolipazy A2 tsitozolia pecheni krys.