title: Basic evaluation of 67Ga labeled digoxin derivative as a metal-labeled bifunctional radiopharmaceutical.
abstract: To develop metal-labeled digoxin radiopharmaceuticals with affinity with anti-digoxin antibody as well as Na+,K(+)-ATPase, a digoxin derivative conjugated with deferoxamine was synthesized. The derivative had a high binding affinity with 67Ga at deferoxamine introduced to the terminal sugar ring of digoxin. The 67Ga labeled digoxin derivative showed enough in vitro binding affinity and selectivity to anti-digoxin antibody as well as Na+,K(+)-ATPase. The 67Ga labeled digoxin derivative is considered to be a potential metal-labeled bifunctional radiopharmaceutical for digoxin RIA as well as myocardial Na+,K(+)-ATPase imaging.
authors.affiliation: School of Medicine, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujibayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Takemura
authors.forename: H
authors.initials: H
authors.lastname: Taniuchi
authors.forename: N
authors.initials: N
authors.lastname: Iijima
authors.forename: J
authors.initials: J
authors.lastname: Konishi
authors.forename: A
authors.initials: A
authors.lastname: Yokoyama
mesh_terms: D003432:Cross-Linking Reagents; D003676:Deferoxamine; D004077:Digoxin; D005069:Evaluation Studies as Topic; D005710:Gallium Radioisotopes; D011849:Radioactive Tracers
chemical_list: D003432:Cross-Linking Reagents; D005710:Gallium Radioisotopes; D011849:Radioactive Tracers; D004077:Digoxin; D003676:Deferoxamine