Anaphylactoid reaction with suramin.
Suramin, a drug used to treat parasitic diseases, is currently being investigated as a treatment for metastatic prostate cancer. A 73-year-old man had an anaphylactoid reaction following the first dose of suramin. It was treated successfully with epinephrine, diphenhydramine, and hydrocortisone. Investigators should be aware of the possibility of such a reaction with parenteral administration of this drug.
Thibault
A
A
Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Figg
W D
WD
Cooper
M R
MR
Prindiville
S A
SA
Sartor
A O
AO
Headlee
D J
DJ
Myers
C E
CE
D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013498:Suramin / Q000008:administration & dosage / Q000009:adverse effects*
D013498:Suramin