title: Rapidly progressive glomerulonephritis (RPGN): is there still an "idiopathic" subgroup?
abstract: In order to clarify if "idiopathic" RPGN still exists as a distinct entity we reviewed 41 patients with histological picture of diffuse crescentic GN (60% of crescents) and no clinical evidence of systemic disease. According to the presence or absence of intraglomerular necrotizing lesions we subdivided the patients into two different morphological groups: Group I (25 pts) with necrotizing GN and massive periglomerular infiltrates; Group II (16 pts) with intra-extracapillary proliferation and no interstitial infiltrates. Our data suggest that "idiopathic" RPGN does not exist as a distinct entity, but is an expression either of renal limited vasculitis or crescentic GN complicating primary proliferative GN.
authors.affiliation: Division of Nephrology, San Carlo Hospital, Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ferrario
authors.forename: M
authors.initials: M
authors.lastname: Tadros
authors.forename: P
authors.initials: P
authors.lastname: Napodano
authors.forename: A
authors.initials: A
authors.lastname: Giordano
authors.forename: R A
authors.initials: RA
authors.lastname: Sinico
authors.forename: G
authors.initials: G
authors.lastname: Fellin
authors.forename: G
authors.initials: G
authors.lastname: D'Amico
mesh_terms: D002196:Capillaries / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000473:pathology; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D009336:Necrosis; D012189:Retrospective Studies
chemical_list: D003176:Complement C3; D005340:Fibrinogen