Neuronal receptors for caerulein in gallbladder.
Release of [3H]-acetylcholine ([3H]ACh) and muscle contractions in response to caerulein was measured and recorded simultaneously from isolated guinea-pig gallbladder. Caerulein (5 x 10(-9) M) enhanced the release of [3H]ACh and the contractions. Tetrodotoxin (10(-6) M) inhibited the caerulein-induced release of [3H]ACh by only 30%. Proglumide and loxiglumide (CR 1505) antagonized the effect of caerulein on both ACh-release and contractions. Neither proglumide nor loxiglumide affected the DMPP-induced contractions and the ACh release. The results suggest not only muscular but also neuronal receptors for caerulein in guinea-pig gallbladder.
Rakovska
A
A
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Milenov
K
K
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D005704:Gallbladder / Q000378:metabolism*; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects; D009474:Neurons / Q000737:chemistry*; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000032:analysis*
D011949:Receptors, Cholecystokinin; C053737:loxiglumide; D002108:Ceruletide; D011377:Proglumide; D000109:Acetylcholine