title: Inhibitory effects of procainamide and probenecid on renal excretion of sultopride enantiomers in rats.
abstract: The effects of the coadministration of procainamide and probenecid on the pharmacokinetic behavior of sultopride, an antipsychotic agent, after intravenous administration were studied with rats. The areas under the concentration-time curve for and renal clearances of (+)-sultopride and (-)-sultopride, which exist as organic cations under physiological pH conditions, were significantly decreased (p < 0.01) by the coadministration of procainamide, an organic cation under physiological pH conditions. The renal clearance of (-)-sultopride was partially decreased (p < 0.05) by the coadministration of probenecid, an organic anion under physiological pH conditions. The results suggest that drug-drug interactions between organic cations and organic anions occur to a certain extent during the tubular secretion process in rats.
authors.affiliation: Department of Pharmacy, Kumamoto University Hospital, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kamizono
authors.forename: N
authors.initials: N
authors.lastname: Inotsume
authors.forename: S
authors.initials: S
authors.lastname: Fukushima
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D000077582:Amisulpride; D000818:Animals; D004347:Drug Interactions; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D011339:Probenecid / Q000494:pharmacology*; D011342:Procainamide / Q000097:blood / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine
chemical_list: D011619:Psychotropic Drugs; D013469:Sulpiride; D000077582:Amisulpride; D011342:Procainamide; D011339:Probenecid