title: Is cortical spoke cataract due to lens fibre breaks? The relationship between fibre folds, fibre breaks, waterclefts and spoke cataract.
abstract: Fibre folds, previously called lamellar separation of the lens, have been found by electron microscopy to be associated with fibre breaks, which are seen in vivo as the circular shades of Obazawa. This led to the present study to determine the relationship between fibre folds, fibre breaks, waterclefts and spoke cataract. All lenses with fibre folds were found to have circular shades. A few instances of circular shades without fibre folds were found, suggesting that the fibre break may be the primary pathology. It was found that circular shades occurred in association with spoke cataract only when fibre folds were also present. Thus there is no essential causal relationship between fibre breaks and spoke cataract. The occurrence of waterclefts was unrelated to the presence of the other features. The lower nasal quadrant of the lens was the most common site for the four features. The depth of spoke cataracts was found to be unrelated to the age of the patient, which makes it unlikely that accommodational stress at the time of onset of presbyopia is causative.
authors.affiliation: Clinical Cataract Research Unit, Nuffield Laboratory of Ophthalmology, Oxford, UK.
authors.forename: N P
authors.initials: NP
authors.lastname: Brown
authors.forename: M L
authors.initials: ML
authors.lastname: Harris
authors.forename: G A
authors.initials: GA
authors.lastname: Shun-Shin
authors.forename: G F
authors.initials: GF
authors.lastname: Vrensen
authors.forename: B
authors.initials: B
authors.lastname: Willekens
authors.forename: A J
authors.initials: AJ
authors.lastname: Bron
mesh_terms: D017668:Age of Onset; D002386:Cataract / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007908:Lens, Crystalline / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged