title: [Sweet's syndrome (acute febrile neutrophilic dermatosis)].
abstract: The clinical presentation and the relation with malignancy of acute febrile neutrophilic dermatosis in 7 patients are described. The syndrome is characterised by fever, neutrophilic granulocytosis, painful erythematous plaques and typical histology consisting of a dense dermal infiltrate of mature neutrophils. The idiopathic form (80% of reported patients) usually follows a viral infection. The secondary form (20% of reported patients) is associated with a malignancy, which in the large majority (85%) is a hematologic disorder (this was the case in 3 of the 7 patients); the course of the syndrome may then be serious. The secondary form of the disease may be associated with an exacerbation of a preexistent malignancy, as was seen in 2 of the 3 patients. If the syndrome runs a serious course the treatment consists of corticosteroid administration.
authors.affiliation: Afd. Algemene Interne Geneeskunde, Academisch Ziekenhuis, Leiden.
authors.forename: R W
authors.initials: RW
authors.lastname: van der Hulst
authors.forename: L M
authors.initials: LM
authors.lastname: Tieben
authors.forename: J J
authors.initials: JJ
authors.lastname: Gerritsen
authors.forename: J A
authors.initials: JA
authors.lastname: Bruijn
authors.forename: J C
authors.initials: JC
authors.lastname: Kluin-Nelemans
mesh_terms: D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
vernacular_title: Het syndroom van Sweet (acute febriele neutrofiele dermatose).