[The association of genetic and functional variability of alpha 1-antitrypsin in asbestosis].
The polymorphism and serum levels of alpha 1-antitrypsin (AT) were studied in asbestosis patients, the control and the workers exposed to mineral flax longer or less than ten years. M1S, M3S, M1Z and M2M2 phenotypes had low concentration of this protein. In the course of contact with mineral flax decrease in alpha 1-AT concentration was found. The phenotypes with low protein levels were very rare among workers contacting with asbestos for a long time, and one of them--M1S was more often encountered in asbestosis patients. The standard deviation from the alpha 1-AT concentration was significantly higher in asbestosis patients.
Afanas'eva
I S
IS
Spitsyn
V A
VA
Tsurikova
G V
GV
D001195:Asbestosis / Q000097:blood / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D000515:alpha 1-Antitrypsin / Q000235:genetics* / Q000502:physiology
D000515:alpha 1-Antitrypsin
Sopriazhennost' geneticheskoĭ i funktsional'noĭ izmenchivosti alpha 1-antitripsina pri asbestoze.