A case of Philadelphia-negative, M-BCR rearranged eosinophilic leukaemia with trisomy 8 localized by in situ hybridization.
A case of Ph-negative M-BCR rearranged eosinophilic leukaemia with clonal cytogenetic abnormalities is presented. In addition to involvement of the short arm of chromosome 12 (12p12?13), the malignant nature of the eosinophils was confirmed by the demonstration of trisomy 8 by in situ hybridization.
Chan
L C
LC
Department of Pathology, University of Hong Kong.
Kwong
Y L
YL
Lie
A K
AK
Ching
L M
LM
D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D002898:Chromosomes, Human, Pair 8; D004273:DNA, Neoplasm / Q000235:genetics; D004804:Eosinophils / Q000502:physiology; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009006:Monosomy / Q000235:genetics; D010677:Philadelphia Chromosome; D014314:Trisomy / Q000235:genetics*
D004273:DNA, Neoplasm; D016044:Fusion Proteins, bcr-abl