title: Relationship between exercise capacity and the severity of emphysema as determined by high resolution CT.
abstract: We investigated the relationship between exercise capacity or exercise-induced hypoxaemia and the severity of pulmonary emphysema in 20 patients with pulmonary emphysema. The patients underwent pulmonary function tests, high resolution computed tomography and incremental treadmill exercise testing. Computed tomography scans were obtained at four levels in the lungs, and emphysema scores were determined by the visual assessment of low attenuation areas as a measure of the severity of parenchymal destruction. The emphysema score correlated significantly with diffusing capacity (r = -0.69) in the pulmonary function tests. Among the exercise test parameters, the emphysema score correlated significantly with the total distance walked (r = -0.74), with maximal oxygen consumption (VO2max) (r = -0.77), with arterial oxygen tension (PaO2) at rest (r = -0.50) and at the maximum workload (r = -0.58), and with the decrement of arterial oxygen tension per litre of oxygen consumed (r = -0.64). These results suggest that exercise capacity and exercise-induced hypoxaemia are related to the extent of destruction of lung parenchyma in patients with pulmonary emphysema.
authors.affiliation: First Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Wakayama
authors.forename: N
authors.initials: N
authors.lastname: Kurihara
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
authors.forename: M
authors.initials: M
authors.lastname: Hata
authors.forename: T
authors.initials: T
authors.lastname: Takeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004646:Emphysema / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005080:Exercise Test; D017079:Exercise Tolerance; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed