[Effect of long-term monotherapy with propranolol and nifedipine on the quality of life and psychological status of patients with hypertension].
WHO criteria of quality of life and psychological status were employed in a randomized placebo-controlled cross-over trial of relevant effects induced by propranolol and nifedipine. Forty patients with essential hypertension (EH) stage I-II aged 35-60, males with diastolic pressure 96-114 mm Hg, entered the trial. Monotherapy with calcium antagonist nifedipine produced a beneficial effect on EH patients' quality of life, they became more sociable and active. Propranolol, beta-adrenoblocker, given for 4 weeks resulted in psychosocial dysadaptation, hypochondriasis, depressions. It is concluded that an antihypertensive effect of the above drugs was related to the EH patients' initial status: one can predict psychological benefit of nifedipine in patients without neurotic symptoms, while propranolol is more effective in neurotic EH subjects.
Manoshkina
E M
EM
Metelitsa
V I
VI
Aĭvazian
T A
TA
Duda
S G
SG
Filatova
N P
NP
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002908:Chronic Disease; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use*; D011581:Psychological Tests; D011788:Quality of Life; D013997:Time Factors
D011433:Propranolol; D009543:Nifedipine
Vliianie dlitel'noĭ monoterapii propranololom i nifedipinom na kachestvo zhizni i psikhologicheskiĭ status bol'nykh gipertonicheskoĭ bolezn'iu.