title: Decreased prostacyclin production by liver non-parenchymal cells precedes liver injury in experimental alcoholic liver disease.
abstract: We used the intragastric feeding rat model for alcoholic liver disease to investigate the relationship between prostacyclin and liver injury. Rats were fed the following diets for periods ranging from 1 to 8 weeks: corn oil plus ethanol (CO+E), corn oil plus dextrose (CO+D), saturated fat plus ethanol (SF+E) and saturated fat plus dextrose (SF+D). Prostacyclin production (assessed by 6-ketoprostaglandin F1 alpha) by liver non-parenchymal cells decreased steadily over the 8 week period in animals fed CO+E (liver injury present) whereas in animals fed SF+E (no liver injury) there was no change in prostacyclin production. Plasma levels of 6-ketoprostaglandin F1 alpha were also significantly lower in the CO+E group compared to the other groups studied. We propose that decreased prostacyclin production by liver non-parenchymal cells may contribute to the hepatotoxic effect of ethanol.
authors.affiliation: Department of Pathology, New England Deaconess Hospital, Boston, MA.
authors.forename: A A
authors.initials: AA
authors.lastname: Nanji
authors.forename: S
authors.initials: S
authors.lastname: Khwaja
authors.forename: S M
authors.initials: SM
authors.lastname: Sadrzadeh
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000818:Animals; D004195:Disease Models, Animal; D011464:Epoprostenol / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol