title: [Bone marrow transplantation in thalassemia].
abstract: Thalassemia major is a progressive disease. Modern therapy with transfusions and iron chelation has greatly improved both the quality and length of thalassemics life. Nevertheless, progressive overload of iron in the organs, hepatitis and other infections acquired randomly imply the risk of mortality that increases with age. Bone marrow transplant from an HLA identical donor (a possibility for about 45%) represents the only form of radical cure of the disease. With the classification of the classes of risk we know today that a thalassemic child has a chance to die from transplant 3 to 100 with probability of being cured 94%. Thalassemics that receive the transplant at a more advanced stage of complications of the disease have a major risk of death due to the transplant of class 2 (14% probability of death due to the transplant against 83% chance of being cured). Class 43 patients have 9 chances out of 100 to die of transplant and 60% probability of being cured of thalassemia.
authors.forename: G
authors.initials: G
authors.lastname: Lukarelli
authors.forename: M
authors.initials: M
authors.lastname: Galimberti
authors.forename: P
authors.initials: P
authors.lastname: Pol'ki
authors.forename: E
authors.initials: E
authors.lastname: Andzheluchchi
authors.forename: D
authors.initials: D
authors.lastname: Baronchiani
authors.forename: K
authors.initials: K
authors.lastname: Dzhardini
authors.forename: S
authors.initials: S
authors.lastname: Duratstsi
authors.forename: F
authors.initials: F
authors.lastname: Agostinelli
authors.forename: K
authors.initials: K
authors.lastname: Dzhordzhi
authors.forename: M
authors.initials: M
authors.lastname: Donati
mesh_terms: D016026:Bone Marrow Transplantation; D006801:Humans; D017086:beta-Thalassemia / Q000628:therapy*
vernacular_title: Transplantatsiia kostnogo mozga pri talassemii.