Development of a natural degradable polymer for orthopaedic use.
Currently, there are a large variety of degradable polymers available for use in surgery, which are generally based on blends and copolymers of poly(L-lactide) (PLLA) and poly(L-glycolide) (PGA). The major demand for these materials is for suturing of wounds, but the materials are also being developed for use in orthopaedic surgery for fracture reduction. The development of these materials is on two fronts, the first involving conventional fracture fixation design of plates. The second is to produce simple devices such as rods and to use the degradable materials for treatment of specific fracture types such as fractures of the olecranon. These materials have the advantage of possessing initially enhanced mechanical properties, although their relatively quick degradation profile diminishes these properties. As an alternative we are developing polyhydroxybutyrate (PHB) and its copolymers with polyhydroxyvalerate (PHV). This range of polymers mab be easily thermally processed, are very cheap and easily available. The polymer also has the significant advantage of being piezoelectric. This is discussed.
Knowles
J C
JC
IRC Biomedical Materials, Queen Mary and Westfield College, London, UK.
D000818:Animals; D001696:Biomechanical Phenomena; D017886:Durapatite; D005269:Femur / Q000473:pathology / Q000601:surgery; D005593:Fracture Fixation, Internal / Q000295:instrumentation*; D006885:Hydroxybutyrates; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers; D011817:Rabbits; D013499:Surface Properties; D000094122:Polyhydroxybutyrates
D017886:Durapatite; D006885:Hydroxybutyrates; D011091:Polyesters; D011108:Polymers; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates