title: Acute renal failure in pregnancy.
abstract: Between 1982 and 1992, 18 cases of pregnancy-related acute renal failure (PR-ARF) were observed (9% of the total number of ARF). Mean age of the women was 32 years (22-40 years). Uterine hemorrhage and preeclampsia/eclampsia were the major causes of ARF, accounting for 61% of the cases. Patchy renal cortical necrosis was suspected in 2 cases whereas signs of disseminated intravascular coagulation (DIC) or microangiopathic hemolytic anemia were present in 6 (33%) and 9 (50%) cases, respectively. Ten women required hemodialysis; and 6 of them, additional plasma exchange sessions. Five patients (28%) died during the acute phase of the illness, mainly due to brain damage, hepatic failure, and sepsis. Among the survivors, a complete (61.5%) or partial recovery (23.1%) was usually seen, but irreversible renal failure was recorded in 2 cases with postpartum hemolytic uremic syndrome (HUS). Short-lasting oligoanuria (< 3 days) represents a good prognostic index. However, the presence of vascular injury (cortical necrosis, HUS) seems to carry a poor prognosis. In conclusion, PR-ARF is still a critical occurrence, associated with serious prognosis for both women and kidneys. So far, the most effective measures remain the careful prevention and the aggressive management of the obstetric complications.
authors.affiliation: Department of Nephrology, Aristotelian University of Thessaloniki, Hippokration General Hospital, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Alexopoulos
authors.forename: P
authors.initials: P
authors.lastname: Tambakoudis
authors.forename: H
authors.initials: H
authors.lastname: Bili
authors.forename: G
authors.initials: G
authors.lastname: Sakellariou
authors.forename: S
authors.initials: S
authors.lastname: Mantalenakis
authors.forename: M
authors.initials: M
authors.lastname: Papadimitriou
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D000328:Adult; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology; D011379:Prognosis; D014592:Uterine Hemorrhage / Q000453:epidemiology