Lack of alachlor induced DNA damage as assayed in rodent liver by the alkaline elution test.
Alachlor was studied in vivo for its capability to induce DNA damage, as evaluated by the alkaline elution test. The experiments were performed in mouse and rat liver after acute or subacute intraperitoneal or per os administrations of the chemical at sublethal dosages. Rat liver was also studied for DNA damage after administration of 2,6-diethylaniline, one of alachlor's major metabolites. Eluted DNA from treated animals was indistinguishable from control DNA. The results show that neither alachlor nor its metabolite cause DNA damage as determined by the number of single strand breaks.
Taningher
M
M
Institute of Oncology-CIRC, University of Genoa/National Institute for Cancer Research, Italy.
Terranova
M P
MP
Airoldi
L
L
Chiappetta
L
L
Parodi
S
S
D000081:Acetamides / Q000633:toxicity*; D000814:Aniline Compounds / Q000633:toxicity; D000818:Animals; D004249:DNA Damage; D006540:Herbicides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000081:Acetamides; D000814:Aniline Compounds; D006540:Herbicides; D009153:Mutagens; C000188:alachlor; C085691:2,6-diethylaniline