Hynapenes A, B and C, new anticoccidial agents produced by Penicillium sp. I. Production, isolation and physico-chemical and biological properties.
Penicillium sp. FO-1611, a soil isolate, was found to produce a series of new anticoccidial compounds. Three active compounds, designated hynapenes A, B and C, were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography, gel filtration on Sephadex LH-20 and preparative HPLC. Hynapenes inhibited the growth of Eimeria tenella in an in vitro assay using BHK-21 cells as a host. No schizont in the cells was observed at concentrations ranging above 123 microM, 34.7 microM and 34.7 microM for hynapenes A, B and C, respectively.
Tabata
N
N
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Tomoda
H
H
Masuma
R
R
Haneda
K
K
Iwai
Y
Y
Omura
S
S
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003049:Coccidiostats / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010407:Penicillium / Q000737:chemistry* / Q000378:metabolism
D003049:Coccidiostats; D009281:Naphthalenes; C085621:hynapene B; C085620:hynapene A; C085622:hynapene C