Role of endorphins in benzodiazepine-induced hyperglycaemia in mice.
The possibility that benzodiazepine-induced hyperglycaemia is mediated through the release of endogenous endorphins was tested. The results show that naloxone, the opiate antagonist, potentiated clonazepam-induced hyperglycaemia. Treatment with increasing doses of morphine for six days, which induced tolerance to endorphins, did not affect clonazepam-induced hyperglycaemia. The results indicate that endorphins do not mediate benzodiazepine-induced hyperglycaemia.
Najim
R A
RA
Department of Pharmacology, College of Medicine, University of Baghdad, Iraq.
Clor
K M
KM
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002998:Clonazepam / Q000494:pharmacology*; D004723:Endorphins / Q000502:physiology*; D006943:Hyperglycemia / Q000139:chemically induced* / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009020:Morphine; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology
D001786:Blood Glucose; D004723:Endorphins; D009270:Naloxone; D002998:Clonazepam; D009020:Morphine