Electrochemical oxidation of anti-tumor agent, etoposide.
As part of a search for new potent derivatives, electrochemical oxidation of etoposide (1) was carried out under controlled potential (500 mV) to yield 1,2-dehydroetoposide (4), 4'-O-demethyl-1,2,3,4-tetradehydro-4-dehydroxy-podophyllotox in (5) and 1,2,3,4-tetradehydroetoposide (6). They showed no cytotoxicity against B16-melanoma.
Obata
R
R
Bristol-Myers Squibb Research Institute, Bristol-Myers Squibb K.K., Tokyo, Japan.
Ohnuma
T
T
D004563:Electrochemistry; D005047:Etoposide / Q000737:chemistry* / Q000494:pharmacology; D008546:Melanoma, Experimental / Q000188:drug therapy; D010084:Oxidation-Reduction
D005047:Etoposide