title: Congenital malformation of the scalp and cranium after failed first trimester abortion attempt with misoprostol.
abstract: This study reports the occurrence of three cases of an unusual congenital malformation of the skull in neonates seen at a pediatric hospital during a five-month interval in Fortaleza, Brazil. The prenatal history focused on the mothers' exposure to drugs during pregnancy. It was found that all mothers had taken misoprostol orally and/or vaginally in the first trimester of pregnancy to induce abortion. Other drugs taken during pregnancy included iron, vitamins and tetanus toxoid. There was no evidence of a family history of malformations, consanguinity or clinical infective illnesses.
authors.affiliation: Department of Social Medicine, Federal University of Pelotas, R.G. Sul, Brazil.
authors.forename: W
authors.initials: W
authors.lastname: Fonseca
authors.forename: A J
authors.initials: AJ
authors.lastname: Alencar
authors.forename: R M
authors.initials: RM
authors.lastname: Pereira
authors.forename: C
authors.initials: C
authors.lastname: Misago
mesh_terms: D000028:Abortion, Induced / Q000379:methods; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000601:surgery; D008297:Male; D016595:Misoprostol / Q000009:adverse effects*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D012535:Scalp / Q000002:abnormalities* / Q000601:surgery; D012886:Skull / Q000002:abnormalities* / Q000601:surgery; D017211:Treatment Failure
chemical_list: D016595:Misoprostol