Common acute lymphoblastic leukemia antigen expression on visceral epithelial cells in several types of glomerulonephritis.
The distribution of a group of glomerular antigens and the composition of deposits was examined by immunoelectron microscopy in patients with idiopathic membranous nephropathy (MN), focal segmental glomerulosclerosis (FSG) and membranoproliferative glomerulonephritis (MPGN). The decrease in expression of common acute lymphoblastic leukemia antigen (CALLA) on glomerular visceral epithelial cells was found in MN and FSG. The loss of CALLA on visceral epithelial cells was typical for immature glomerulus and for this cell culture. On the strength of these results we can suppose that the dedifferentiation of visceral epithelial cells takes place in MN and FSG. It leads to changes in the synthesis of the glomerular basement membrane components.
Ivanov
A
A
Department of Pathological Anatomy, Sechenov Medical Academy, Moscow, Russia.
Paltsev
M
M
D000936:Antigen-Antibody Complex / Q000032:analysis / Q000378:metabolism; D004848:Epithelium / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D005921:Glomerulonephritis / Q000378:metabolism* / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000378:metabolism* / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D016253:Microscopy, Immunoelectron; D015260:Neprilysin / Q000032:analysis* / Q000378:metabolism; D011951:Receptors, Complement / Q000032:analysis / Q000378:metabolism; D014781:Viscera / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology
D000936:Antigen-Antibody Complex; D011951:Receptors, Complement; D015260:Neprilysin