Detection of antineutrophil cytoplasmatic antibodies (ANCA) and their association with other autoantibodies in patients with hepatobiliary disorders.
Sera from 35 out of 655 patients with suspected or confirmed hepatobiliary diseases were positive for anti-neutrophil antibodies with a perinuclear staining pattern (p-ANCA). Nineteen of these sera did not react with myeloperoxidase (MPO), Cathepsin G or Elastase, the three proposed antigens of p-ANCAs. No distinct antigen for these sera could be characterized by western blot techniques with fractionated granulocyte proteins.
Gruber
R
R
Institute for Immunology, University of Munich, Germany.
Brockmeyer
C
C
Hoechtlen-Vollmar
W
W
Bittlingmaier
R
R
Trimborn
S
S
Riethmüller
G
G
D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood*; D001660:Biliary Tract Diseases / Q000276:immunology*; D015153:Blotting, Western; D056649:Cathepsin G; D002403:Cathepsins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008107:Liver Diseases / Q000276:immunology*; D010196:Pancreatic Elastase / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D012697:Serine Endopeptidases
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; D009195:Peroxidase; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase