Effects of snuff on regional blood flow to the cheek and tongue of anesthetized dogs.
Regional blood flow to the cheek and tongue of anesthetized dogs was measured before and after application of six different doses of snuff (3.12 to 100 mg/kg body weight) to the right cheek. Dose-independent vasodilation was observed at the site of application, whereas dose-dependent vasoconstriction was observed contralaterally. Aortic, central venous, and ventricular pressures were significantly increased (p < 0.05) at the higher doses. Plasma nicotine concentrations increased stepwise with dose.
Huckabee
K D
KD
Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth.
Barnes
R T
RT
Williams
A G
AG
Fan
W L
WL
Downey
H F
HF
D000704:Analysis of Variance; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002496:Central Venous Pressure / Q000187:drug effects; D002610:Cheek / Q000098:blood supply; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006940:Hyperemia / Q000139:chemically induced*; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply*; D009538:Nicotine / Q000097:blood; D010947:Plants, Toxic; D010992:Plethysmography, Impedance; D012039:Regional Blood Flow / Q000187:drug effects; D014030:Tobacco, Smokeless / Q000633:toxicity*; D014059:Tongue / Q000098:blood supply; D014661:Vasoconstriction; D014664:Vasodilation
D009538:Nicotine