title: The effects of single doses of CL284,846, lorazepam, and placebo on psychomotor and memory function in normal male volunteers.
abstract: The effects of single doses of CL284,846 (20 mg), lorazepam (2 mg) and placebo on psychomotor performance, memory function and subjective feelings were assessed in 12 normal, healthy male volunteers. Each subject received each treatment in balanced order and a minimum of 6 days was left between treatments. The subjects performance on a comprehensive battery of tests of psychomotor performance, memory function and subjective ratings was assessed pre-treatment and at 1, 3 and 5 h post-treatment. In general, the effects of CL284,846 on memory were similar to those of lorazepam at 1 h post-treatment but, recovery was rapid with CL284,846. Impairments induced by lorazepam persisted throughout the post-drug testing sessions. This pattern of effects was repeated across most of the variables tested. However, at 1 h, CL284,846 produced less marked psychomotor impairment than lorazepam. The results of this study suggest that CL284,846 is a safe, rapid acting and effective sedative with some clear advantages over lorazepam with respect to unwanted cognitive and psychomotor impairments.
authors.affiliation: Department of Psychiatry, Institute of Psychiatry, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Allen
authors.forename: H V
authors.initials: HV
authors.lastname: Curran
authors.forename: M
authors.initials: M
authors.lastname: Lader
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000339:Affect / Q000187:drug effects; D004311:Double-Blind Method; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000081:Acetamides; D011743:Pyrimidines; D008140:Lorazepam; C085665:zaleplon