Locoregional immunotherapy of head and neck cancers utilizing allogeneic spleen cells--a report of 2 cases.
Frozen-stored human spleen cells (SC) cultured with streptococcus preparation OK-432 acquired direct cytotoxicity to autologous as well as allogeneic tumor cells. The activated cells started to produce cytocidal cytokine TGIF, which is distinct from previously known cytokines. We examined the possibility of allogeneic adoptive immunotherapy (AIT) using these OK-432-stimulated spleen cells (OK-SC) in two cancer patients. Rapid necrosis of cancer tissue and remarkable decreases of tumor markers in tumor effusion were observed. There were no severe side effects.
Kubota
E
E
Department of Oral and Maxillofacial Surgery, Saga Medical School, Japan.
Katano
M
M
Imamura
H
H
Kurokawa
H
H
Katsuki
T
T
Yamamoto
H
H
Hisatsugu
T
T
Nagumo
F
F
Tadano
J
J
D000368:Aged; D000970:Antineoplastic Agents / Q000276:immunology / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D005260:Female; D006258:Head and Neck Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis / Q000494:pharmacology; D010844:Picibanil / Q000494:pharmacology; D013154:Spleen / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000970:Antineoplastic Agents; D008222:Lymphokines; D010844:Picibanil