title: Selective inhibition of dihydrofolate reductase from problem human pathogens.
authors.affiliation: F. Hoffmann-La Roche Ltd, Basel/Switzerland.
authors.forename: R L
authors.initials: RL
authors.lastname: Then
authors.forename: P G
authors.initials: PG
authors.lastname: Hartman
authors.forename: I
authors.initials: I
authors.lastname: Kompis
authors.forename: D
authors.initials: D
authors.lastname: Santi
mesh_terms: D004926:Escherichia coli / Q000201:enzymology* / Q000472:pathogenicity; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D011010:Pneumocystis / Q000201:enzymology* / Q000472:pathogenicity; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000472:pathogenicity; D013329:Structure-Activity Relationship; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D005493:Folic Acid Antagonists; D014295:Trimethoprim