title: Effect of small doses of ethylene glycol monomethyl ether on the acetylcholinesterase and delta-aminolevulinic acid dehydratase activity in erythrocytes, blood and bone marrow of rats.
abstract: The effect of small doses of ethylene glycol monomethyl ether (EGMME) on the activity of acetylcholinesterase (ACHE) in erythrocytes and whole blood as well as on the delta-aminolevulinic acid dehydratase (ALA-D) in blood and bone marrow was studied in Wistar rats. Significant reduction in the activity of both enzymes was noted three days after ip administration of 200 mg/kg b.w. EGMME whereas seven days later the activity of both enzymes returned to the control levels. Activity of ALA-D in blood appeared to be most sensitive to EGMME, and reacted even to the lowest dose, which did not significantly alter activity of ACHE or ALA-D in bone marrow. Haematological parameters in all treated groups remained unaltered.
authors.affiliation: Laboratory of Experimental Hematology and Toxicology, Jagiellonian University, Kraków, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Lazewska
authors.forename: Z
authors.initials: Z
authors.lastname: Tabarowski
authors.forename: Z
authors.initials: Z
authors.lastname: Dabrowski
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D006403:Hematologic Tests; D008297:Male; D000623:Porphobilinogen Synthase / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D005026:Ethylene Glycols; D012997:Solvents; D000110:Acetylcholinesterase; D000623:Porphobilinogen Synthase; C005219:methyl cellosolve