[Decrease in the level of free cholesterol fraction HDL as a risk factor for threatened atherosclerosis in idiopathic hyperinsulinemia].
Inversive association between concentration of plasma high density lipoprotein (HDL) components and endogenous insulin response to oral glucose uptake was observed in 89 healthy, normolipidaemic, non obese, non diabetic male subjects. Inversive correlation between sum of insulin released during oral glucose tolerance test and HDL free and esterified cholesterol as well as apolipoprotein A1 concentration were confirmed. Coexistence of increased insulin secretion and low ratio of free cholesterol concentration to esterified cholesterol and to proteins in HDL was also observed. In separate group of subjects with normal glucose tolerance in high insulin response subgroup the cholesterol (free and esterified) and protein concentrations were lower than in subgroup with low insulin response. The free cholesterol/esterified cholesterol and free cholesterol/protein (apoA1) ratios were decreased in high insulin response subgroup. It is concluded that low concentration of free cholesterol is a most significant change of HDL composition in hyperinsulinemic, healthy men.
Goldsztajn
P
P
Katedra Biochemii Klinicznej Akademii Medycznej, Krakowie.
Hartwich
J
J
Kwasniak
M
M
Wenhrynowicz
O
O
Zdzienicka
A
A
Wybrańska
I
I
Dembińska-Kiec
A
A
D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology*; D008076:Cholesterol, HDL / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors
D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D007328:Insulin
Zmniejszenie stezenia wolnego cholesterolu frakcji HDL czynnikiem zagrozenia miazdzyca w samoistnej hiperinsulinemii.