Bisbenzylisoquinoline alkaloids from Cyclea barbata.
Continuing studies of the alkaloidal fraction from the roots of Cyclea barbata afforded two new bisbenzylisoquinoline alkaloids, namely, (-)-2'-norlimacine [1] and (+)-cycleabarbatine [2]. The known (+)-tetrandrine-2'-beta-N-oxide [3], for which the configuration of the N-oxide function is now assigned, was identified, as were (+)-berbamine, (-)-repandine, (+)-cycleanorine, (+)-daphnandrine, (-)-curine, (+)-coclaurine, and (-)-N-methylcoclaurine.
Guinaudeau
H
H
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612.
Lin
L Z
LZ
Ruangrungsi
N
N
Cordell
G A
GA
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D044182:Benzylisoquinolines; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D000470:Alkaloids; D044182:Benzylisoquinolines; D007546:Isoquinolines; C085398:cycleabarbatine; C085399:2'-norlimacine; C009438:tetrandrine