Erythroid differentiation-inducing activity of protoporphyrin IX and its analogs on human leukemia K562 cell line.
Protoporphyrin IX, which had been regarded as ineffective in cell differentiation, induced erythroid differentiation of K562 cell line, and its analogs such as hematoporphyrin IX, mesoporphyrin IX, deuteroporphyrin IX and protoporphyrin IX dimethyl ester were also differentiation inducers. The differentiation induced by these compounds was augmented by a retinoid, as is hemin-induced differentiation.
Nakajima
O
O
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Hashimoto
Y
Y
Iwasaki
S
S
D001565:Benzoates / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004920:Erythropoiesis / Q000187:drug effects*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D011166:Porphyrins / Q000494:pharmacology*; D011524:Protoporphyrins / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D001565:Benzoates; D011166:Porphyrins; D011524:Protoporphyrins; D013764:Tetrahydronaphthalenes; C061133:tamibarotene; C028025:protoporphyrin IX