Value of urinary endothelin-1 in patients with primary vesicoureteral reflux.
By using a radioimmunoassay specific for endothelin-1 (ET-1), we measured urinary excretion of ET-1-like immunoreactivity (LI) in 63 spot urine samples of 48 patients with primary vesicoureteral reflux (VUR). And also, urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), beta 2-microglobulin (beta-2-MG), microalbumin (Alb) and creatinine (Cr) were measured. There was no significant correlation in any of the pairs ET-1 and NAG, ET-1 and beta 2-MG, and ET-1 and Alb. Comparing the grade of reflux according to the International Classification with urinary ET-1, urinary ET-1/Cr levels in patients with grade 2, 3 and 4 VUR were higher than normal, and the ratio of more than normal urinary ET-1/Cr increased in proportion to the grade of reflux, but it conversely decreased in grade 5. In conclusion, urinary ET-1 may be an indicator of renal tubular injury in patients with primary VUR, and its meaning may be different from conventional urinary parameters.
Komeyama
T
T
Department of Urology, Niigata University School of Medicine, Japan.
Takeda
M
M
Katayama
Y
Y
Tsutsui
T
T
Mizusawa
T
T
Takahashi
H
H
Hatano
A
A
Obara
K
K
Sato
S
S
D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers / Q000652:urine; D002648:Child; D002675:Child, Preschool; D002857:Chromium / Q000652:urine; D003404:Creatinine / Q000652:urine; D016232:Endothelins / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000175:diagnosis / Q000652:urine; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D004113:Succimer / Q000493:pharmacokinetics; D014718:Vesico-Ureteral Reflux / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
D015415:Biomarkers; D016232:Endothelins; D001613:beta 2-Microglobulin; D002857:Chromium; D003404:Creatinine; D004113:Succimer; D000118:Acetylglucosaminidase