title: Mustard oil-induced cutaneous inflammation in the pig.
abstract: Recent findings indicate that chemical stimulation of the porcine skin with capsaicin evokes a flare response similar to that observed in man. The aim of the present study was to elucidate whether chemical stimulation of cutaneous capsaicin-sensitive nerve endings with mustard oil produces neurogenic inflammatory reactions in the pig. The application of mustard oil onto the abdominal skin of domestic pigs resulted in a pronounced flare response. After a previous intravenous injection of a solution of Evans blue, the skin area in contact with the irritant turned dark blue, indicating a marked extravasation of albumin. Quantitative estimation of the dye content of the skin supported this conclusion. The technique of vascular labelling revealed a delicate network of small subepidermal blood vessels in histological preparations after the application of mustard oil following a previous intravenous injection of colloidal silver. Labelled blood vessels were not noted outside the treated area. The present results show that mustard oil produces a strong cutaneous inflammatory response in the pig, and suggest that the porcine skin provides a valuable model for study of the significance of capsaicin-sensitive sensory nerves in vascular and other cutaneous reactions.
authors.affiliation: Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Jancsó
authors.forename: F K
authors.initials: FK
authors.lastname: Pierau
authors.forename: H
authors.initials: H
authors.lastname: Sann
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000473:pathology*; D009149:Mustard Plant; D009411:Nerve Endings / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D010938:Plant Oils; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000473:pathology*; D013268:Stimulation, Chemical; D013552:Swine
chemical_list: D010936:Plant Extracts; D010938:Plant Oils; D002211:Capsaicin; C027793:mustard oil