Efficacy of Brucella suis strain 2 vaccine against Brucella ovis in rams.
The protective efficacy against Brucella ovis of live vaccine Brucella suis strain 2 (S2) and Brucella melitensis strain Rev 1 has been evaluated in rams. Fourteen 4-month-old Brucella-free Aragonesa rams were vaccinated conjunctivally with 2 x 10(9) c.f.u. S2. Sixteen rams of the same breed, condition and age were conjunctivally vaccinated the same day with 1.6 x 10(9) Rev 1. Thirteen rams were unvaccinated controls. Eight months after vaccination all rams were challenged with 6 x 10(9) c.f.u. B. ovis and slaughtered 2 months thereafter for bacteriological and pathological studies. The percentage of infection in the group vaccinated with Rev 1 (43.7%) was significantly lower (p < 0.05) than that of the S2-vaccinated animals (78.6%) and unvaccinated controls (84.6%). No significant differences were found when comparing the percentages of infection corresponding to S2-vaccinated and control groups. The degree of infection (percentage of necropsy samples infected) was significantly lower in Rev 1-vaccinated (13%) than in S2-vaccinated (36.9%) or control groups (47.4%) (p < 0.001). However, no significant differences were found when comparing S2-vaccinated and control groups.
Blasco
J M
JM
Servicio de Investigación Agraria, Diputación General de Aragón, Zaragoza, Spain.
Marín
C
C
Jiménez de Bagüés
M P
MP
Barberán
M
M
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D002002:Brucella / Q000276:immunology*; D002004:Brucella Vaccine / Q000494:pharmacology*; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control*; D014611:Vaccination
D002004:Brucella Vaccine