title: Function of a human cyclin gene as an oncogene.
abstract: The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.
authors.affiliation: Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142.
authors.forename: P W
authors.initials: PW
authors.lastname: Hinds
authors.forename: S F
authors.initials: SF
authors.lastname: Dowdy
authors.forename: E N
authors.initials: EN
authors.lastname: Eaton
authors.forename: A
authors.initials: A
authors.lastname: Arnold
authors.forename: R A
authors.initials: RA
authors.lastname: Weinberg
mesh_terms: D017500:Adenovirus E1A Proteins / Q000235:genetics; D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002478:Cells, Cultured; D019938:Cyclin D1; D016213:Cyclins / Q000235:genetics*; D003673:Defective Viruses / Q000235:genetics; D005814:Genes, Viral; D005816:Genetic Complementation Test; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D015513:Oncogene Proteins / Q000235:genetics*; D009857:Oncogenes; D051381:Rats; D014162:Transfection
chemical_list: D017500:Adenovirus E1A Proteins; D016213:Cyclins; D015513:Oncogene Proteins; D019938:Cyclin D1