Conditioned enhancement of antibody production using antigen as the unconditioned stimulus.
Antigen is the most salient stimulus for an unconditional activation of the immune system. BALB/c mice were given repeated immunizations with keyhole limpet hemocyanin (KLH) paired with a gustatory conditioned stimulus (CS). A classically conditioned enhancement of anti-KLH antibody titers was observed when conditioned mice were reexposed to the CS in the context of reexposure to a minimally immunogenic dose of that same antigen. An interaction between signals derived from the neuroendocrine and immune systems is hypothesized to mediate this conditioned immune response.
Ader
R
R
Center for Psychoneuroimmunology Research, University of Rochester School of Medicine and Dentistry, New York 14642.
Kelly
K
K
Moynihan
J A
JA
Grota
L J
LJ
Cohen
N
N
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D003214:Conditioning, Classical / Q000502:physiology*; D006433:Hemocyanins / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000941:Antigens; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin