Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice.
Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies.
Finch
G R
GR
Department of Civil Engineering, University of Alberta, Edmonton, Canada.
Daniels
C W
CW
Black
E K
EK
Schaefer
F W
FW
Belosevic
M
M
D000818:Animals; D000831:Animals, Newborn; D003457:Cryptosporidiosis / Q000209:etiology*; D016785:Cryptosporidium parvum / Q000302:isolation & purification / Q000472:pathogenicity*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D011634:Public Health; D014881:Water Supply