Ph+ acute myelogenous leukemia with t(7;11)(p15;p15) and clonal evolution in relapse after bone marrow transplantation.
A 20-year-old female with Ph+ acute myelogenous leukemia (M2) associated with t(7;11)(p15;p15) is reported. Bone marrow aspirates were hypercellular with leukemic cells including Auer rods. Chromosome analysis showed t(7;11) and the Ph chromosome. After complete remission, normal karyotype was restored. Normal male karyotypic cells replaced the bone marrow following allogeneic bone marrow transplantation from her brother. On day 358, cytogenetic study at relapse revealed 14q+ as an additional change and clearly showed that the abnormal clone was derived from the patient, because metaphases with XX were all of abnormal karyotype and those with XY were normal.
Miura
I
I
Third Department of Internal Medicine, Akita University School of Medicine, Japan.
Nishinari
T
T
Hashimoto
K
K
Nimura
T
T
Takatsu
H
H
Niitsu
H
H
Hirokawa
M
M
Kuwayama
A
A
Nishimura
S
S
Miura
A B
AB
D000328:Adult; D016026:Bone Marrow Transplantation; D002880:Chromosomes, Human, Pair 11; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D012008:Recurrence; D014178:Translocation, Genetic