Dorsal root ganglion proteins in Friedreich's ataxia.
The polypeptide composition of dorsal root ganglia from 8 human controls, 6 Friedreich's ataxia (FA) patients and 1 patient with diabetic neuropathy was studied by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis (PAGE). Silver-stained gels demonstrated a decrease in a 40-kDa protein in FA patients. This protein appeared to be present in normal amounts in the diabetic ganglion, suggesting that this 40-kDa protein deficiency was not simply a reflection of reduced neuronal numbers but may be specific for FA.
Small
J R
JR
Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
Thomas
P K
PK
Schapira
A H
AH
D003929:Diabetic Neuropathies / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005621:Friedreich Ataxia / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000302:isolation & purification; D012016:Reference Values
D009419:Nerve Tissue Proteins