Dipeptides in parenteral nutrition: from basic science to clinical applications.
The use of intravenous dipeptides shows great promise as an avenue for the provision of amino acids that may otherwise be difficult to deliver via nutrient infusions. The physical/chemical properties and metabolism of numerous dipeptides have now been explored in experimental and human studies. It has been found that these agents have the capacity to spare nitrogen and support serum protein levels in a fashion equivalent to that of intravenous free amino acids. An additional benefit is the ability to deliver certain amino acids that are relatively unstable or poorly soluble in aqueous solutions. These various aspects of intravenous dipeptides are considered in this review.
Vazquez
J A
JA
Daniel
H
H
Adibi
S A
SA
D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects; D002986:Clinical Trials as Topic; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D010288:Parenteral Nutrition / Q000379:methods*; D051381:Rats
D001798:Blood Proteins; D004151:Dipeptides