Multivariate statistical analysis of bile cytology.
Cytologic features predictive of carcinoma in bile fluid were characterized by a review of 35 cases (22 malignant and 13 benign). Thirty-two cytologic variables were subjected to a stepwise multiple regression model to separate the criteria best suited to the benign versus malignant groups. Six key criteria were selected as useful indicators of malignancy: loss of honeycomb arrangement, enlarged nuclei, loss of polarity, bloody background, flat nuclei and cell-in-cell arrangement. Three or more of these criteria were observed in carcinoma cases more often than they were in noncancer cases (P < .01). By using these criteria, the overall sensitivity of diagnosing carcinoma by bile cytology was 86.4%, and the specificity was 76.9%.
Nakajima
T
T
Department of Surgical Pathology, Teikyo University, School of Medicine, Ichihara Hospital, Chiba, Japan.
Tajima
Y
Y
Sugano
I
I
Nagao
K
K
Sakuma
A
A
Koyama
Y
Y
Kondo
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D001646:Bile / Q000166:cytology*; D001660:Biliary Tract Diseases / Q000473:pathology*; D001661:Biliary Tract Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D002277:Carcinoma / Q000473:pathology* / Q000648:ultrastructure; D003581:Cytodiagnosis / Q000706:statistics & numerical data; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000648:ultrastructure; D012044:Regression Analysis; D012680:Sensitivity and Specificity