Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies.
Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudo-obstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.
Condom
E
E
Servicio Anatomía Patológica, Hospital Príncipes de España, Hospitalet de Llobregat, Spain.
Vidal
A
A
Rota
R
R
Graus
F
F
Dalmau
J
J
Ferrer
I
I
D000912:Antibodies, Neoplasm / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000276:immunology / Q000473:pathology*
D000912:Antibodies, Neoplasm