title: Transcutaneous minoxidil in the treatment of erectile dysfunctions in spinal cord injured men.
abstract: We have tested the erectile effect of a topical applied drug (Minoxidil) in 15 spinal cord injured men. Minoxidil exerts a direct relaxant effect on arterial smooth muscles. This topical vasodilatory agent (1 ml of a 2% solution) was applied on the skin of the penile shaft. Increases in diameter and rigidity were measured with the RigiScan device (Dacomed Minneapolis, Minnesota). A total of 4 paraplegic men with a complete dorsal level lesion reported a positive erectile response. 3 of these 4 patients preferred to continue with this noninvasive treatment compared to prostaglandin E1 intracavernous injections. In our study no side effects were emerged and minoxidil proved to be well tolerated at the cutaneous level of the penis. Our results indicate that this treatment should be tested in spinal cord injured men before a invasive therapy is initiated.
authors.affiliation: Unità di Andrologia, Ospedale G. Fornaroli Magenta, Milano.
authors.forename: G
authors.initials: G
authors.lastname: Beretta
authors.forename: O
authors.initials: O
authors.lastname: Saltarelli
authors.forename: M
authors.initials: M
authors.lastname: Marzotto
authors.forename: A
authors.initials: A
authors.lastname: Zanollo
authors.forename: B
authors.initials: B
authors.lastname: Re
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D008914:Minoxidil / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010264:Paraplegia / Q000150:complications* / Q000503:physiopathology; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000187:drug effects; D013119:Spinal Cord Injuries / Q000150:complications* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D008914:Minoxidil