title: Commentary: regulatory issues affecting oligonucleotides.
authors.affiliation: ISIS Pharmaceuticals, Carlsbad Research Center, California 92008.
authors.forename: S T
authors.initials: ST
authors.lastname: Crooke
mesh_terms: D000327:Adsorption; D001682:Biological Availability; D002986:Clinical Trials as Topic; D017277:Drug Approval; D015195:Drug Design; D004345:Drug Industry; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution
chemical_list: D016376:Oligonucleotides, Antisense