Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat.
1. Sex differences observed in the metabolism of pentachlorothioanisole in rat were due to: (1) greater excretion in urine by females, and greater biliary excretion by males; (2) formation of pentachlorophenyl mercapturic acid pathway metabolites by females; and (3) redox-cycling between methylthio and methylsulphoxyl oxidation congeners in intermediary metabolites by females. 2. Three methylthio-turnover processes are proposed in the intermediary metabolism of pentachlorothioanisole.
Bakke
J E
JE
US Department of Agriculture, Biosciences Research Laboratory, Fargo, ND 58105.
Mulford
D J
DJ
Huwe
J K
JK
Feil
V J
VJ
Davison
K L
KL
D000818:Animals; D001646:Bile / Q000378:metabolism; D002722:Chlorobenzenes / Q000378:metabolism* / Q000652:urine; D004350:Drug Residues; D005260:Female; D005978:Glutathione / Q000502:physiology*; D008297:Male; D008745:Methylation; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D002722:Chlorobenzenes; D013438:Sulfhydryl Compounds; C031281:pentachloromethylthiobenzene; D005978:Glutathione