title: Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: a multiple regression/discriminant analysis of positron emission tomographic data.
abstract: A multiple regression/discriminant analysis of positron emission tomographic cerebral metabolic (rCMRglc) data in 10 obsessive-compulsive disorder (OCD) patients before and during pharmacotherapy was carried out to see if rCMRglc interdependencies distinguished OCD patients from controls. Before therapy, a discriminant function reflecting parietal, sensorimotor, and midbrain rCMRglc interdependencies correctly classified eight (80%) of the 10 patients as OCD; after therapy, six (70%) were classified as controls, most of whom were responders. Before therapy, rCMRglc interdependencies involving basal ganglia, thalamus, limbic, and sensory and association cortical regions distinguished 67% of patients who clinically responded to drug (RESP, n = 6) and 75% of patients who did not (NRESP, n = 4) from controls. After therapy, all RESP were classified as controls; classification of NRESP remained unchanged. The results suggest the conjunctive utility of this method to assess individual differences in rCMRglc during pharmacotherapy, and to explore the neurobiology of OCD.
authors.affiliation: Laboratory of Neurosciences, National Institute of Aging/NIH, Bethesda, MD 20892.
authors.forename: N P
authors.initials: NP
authors.lastname: Azari
authors.forename: P
authors.initials: P
authors.lastname: Pietrini
authors.forename: B
authors.initials: B
authors.lastname: Horwitz
authors.forename: K D
authors.initials: KD
authors.lastname: Pettigrew
authors.forename: H L
authors.initials: HL
authors.lastname: Leonard
authors.forename: J L
authors.initials: JL
authors.lastname: Rapoport
authors.forename: M B
authors.initials: MB
authors.lastname: Schapiro
authors.forename: S E
authors.initials: SE
authors.lastname: Swedo
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D002997:Clomipramine / Q000627:therapeutic use*; D016002:Discriminant Analysis; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D012044:Regression Analysis; D013997:Time Factors; D014055:Tomography, Emission-Computed
chemical_list: D005473:Fluoxetine; D002997:Clomipramine