title: Effect of a high fat diet on phospholipid class distribution and fatty acid composition in rat liver.
abstract: 1. Long term consumption (20 weeks) of a high fat diet (65% of the energy content as fat) rich in either saturated [30% (w/w) coconut oil] or unsaturated [30% (w/w) sunflower oil] fatty acids resulted in strikingly similar alterations in the phospholipid class distribution and fatty acid composition in the liver of male Wistar rats. 2. The effect of these two diets was compared to a control group maintained on a 2% fat diet (w/w) for the same time interval. 3. In spite of the difference in the PUFA/SFA (polyunsaturated fatty acid/saturated fatty acid) ratio between the two high fat diets (0.1, saturated fatty acid diet; 5.4, unsaturated fatty acid diet), both diets resulted in a similar PUFA/SFA ratio in liver phospholipids, a similar reduction in palmitic acid (16:0), oleic acid (18:1, n-9) and arachidonic acid (20:4, n-6) and an elevation in stearic acid (18:0), linoleic acid (18:2, n-6) and docosahexaenoic acid (22:6, n-3). 4. Further, changes in the phospholipid classes were also similarly affected by both high fat diets.
authors.affiliation: Institute of Medical Chemistry and Pregl Laboratory, University of Graz, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Mlekusch
authors.forename: C
authors.initials: C
authors.lastname: Celedin
authors.forename: R C
authors.initials: RC
authors.lastname: Aloia
authors.forename: R
authors.initials: R
authors.lastname: Moller
mesh_terms: D000818:Animals; D001835:Body Weight; D002855:Chromatography, Thin Layer; D000074263:Coconut Oil; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010743:Phospholipids / Q000378:metabolism*; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D010743:Phospholipids; D010938:Plant Oils; D000074242:Sunflower Oil; D000074263:Coconut Oil