Endocrine changes and follicular development in patients during ovulation induction using Goserelin and different gonadotropin treatments.
The aim of this study was to compare endocrine changes and the follicular development in patients receiving pure FSH alone or in association with LH after desensitization with an LH-RH agonist depot. Thirty four cycles were selected for this prospective randomized study. Desensitization was obtained using Goserelin the cycle before the stimulation. Induction of ovulation for IUI was carried out with 225 IU/day of pure FSH or with 225 IU/day of hMG. The number of days and ampules required for follicular maturation were equivalent in the two groups. The same number of follicles were developed, while different, but not significant, pregnancy rates were obtained. Estradiol values at the end of stimulation were significantly lower for FSH group. In conclusion the contemporary administration of LH with FSH does not exert any effect on follicular development, but it seems to facilitate E2 synthesis, probably providing more substrate for the aromatization process.
Gerli
S
S
Department of Obstetrics and Gynecology, University of Perugia, Italy.
Villani
C
C
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004958:Estradiol / Q000096:biosynthesis*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D006065:Gonadotropins, Pituitary / Q000494:pharmacology* / Q000627:therapeutic use; D017273:Goserelin / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007986:Luteinizing Hormone / Q000494:pharmacology / Q000627:therapeutic use; D008596:Menotropins / Q000097:blood / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy / Q000187:drug effects; D011446:Prospective Studies
D006063:Chorionic Gonadotropin; D006065:Gonadotropins, Pituitary; D017273:Goserelin; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone