title: Nervous tissue proteoglycans.
abstract: The structure, biosynthesis, localization, and possible functional roles of nervous tissue glycosaminoglycans and proteoglycans were last reviewed several years ago. Since that time, there has been an exponential increase in publications on the neurobiology of proteoglycans. This review will therefore focus on reports which have appeared in the period after 1988, and especially on those concerning the properties of individual characterized nervous tissue proteoglycans. Related areas such as the regulation of glycosaminoglycan biosynthesis and the roles of cell surface proteoglycans in adhesion and growth control are covered in other contributions to this special topic issue.
authors.affiliation: Department of Pharmacology, State University of New York, Health Science Center, Brooklyn 11203.
authors.forename: R K
authors.initials: RK
authors.lastname: Margolis
authors.forename: R U
authors.initials: RU
authors.lastname: Margolis
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D011508:Chondroitin Sulfate Proteoglycans / Q000032:analysis / Q000378:metabolism; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D006801:Humans; D007632:Keratan Sulfate / Q000032:analysis / Q000378:metabolism; D037181:Lectins, C-Type; D000071234:Lumican; D009417:Nerve Tissue / Q000378:metabolism*; D011509:Proteoglycans / Q000737:chemistry* / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000378:metabolism; D053675:Versicans
chemical_list: D016564:Amyloid beta-Protein Precursor; D011508:Chondroitin Sulfate Proteoglycans; D053379:Chromogranin A; D002864:Chromogranins; C000604306:LUM protein, human; D037181:Lectins, C-Type; D000071234:Lumican; D011509:Proteoglycans; C508322:VCAN protein, human; D053675:Versicans; D007632:Keratan Sulfate