Short course ciprofloxacin therapy for enteric fever.
A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treatment of enteric fever in 21 hospitalized patients with S.typhi (18) and S.paratyphi A(3). Median time for fever response was 3 days. All isolates were susceptible to ciprofloxacin (MIC 0.0078-0.062 mcgm/ml). The mean serum peak and trough levels were 5.4 and 1.6 mcgm/ml respectively. Stool cultures were free of Salmonellae on follow up (11-24 weeks). Two developed recurrence of paratyphoid fever, 17 days and 4 months after therapy.
Mathai
D
D
Department of Medicine, Christian Medical College and Hospital, Vellore, India.
Kudva
G C
GC
Keystone
J S
JS
Kozarsky
P E
PE
Jesudason
M V
MV
Lalitha
M K
MK
Kaur
A
A
Thomas
M
M
John
J
J
Pulimood
B M
BM
D000328:Adult; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D010284:Paratyphoid Fever / Q000188:drug therapy*; D012008:Recurrence; D012482:Salmonella paratyphi A / Q000302:isolation & purification*; D013997:Time Factors; D014435:Typhoid Fever / Q000188:drug therapy*
D002939:Ciprofloxacin