title: [Development of pentylenetetrazol kindling model].
abstract: An ideal animal model of chemical kindling mimicking human epilepsy was developed in 28 day-old rats. Rats were given pentylenetetrazol (PTZ) 30 mg/kg, ip, once per day for 28 consecutive days; after stopping treatment for one week, the rats were retreated using the same dose of PTZ until reaching the kindled criterion. The kindled rate was 74%. The behavioral seizure and EEG discharges were synchronized. All kindled rats still kept their high seizure state after the experiments.
authors.affiliation: Pediatric laboratory, First Teaching Hospital, Beijing Medical University.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Ono
authors.forename: P D
authors.initials: PD
authors.lastname: Walson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced*; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010433:Pentylenetetrazole