title: Prognosis of depression in the elderly. A comparison with younger patients.
abstract: The prognosis of depression in the elderly was investigated in a mixed-age sample of 242 consecutive referrals, with DSM-III defined unipolar major depressive episode, to a specialist unit for mood disorders. Subjects were followed up at about 1 and 3.8 years. There was no significant difference in outcome between younger (under 40 years), middle aged (40-59 years) and older (60 years or more) depressed patients. For the 61 elderly subjects with depression, prognosis improved with time, with 25% having a lasting recovery at the first and 41% at the second follow-up. Early onset, recurrence, and poor premorbid personality were associated with a worse prognosis. Three (5%) elderly depressives had committed suicide and seven (11%) had died from natural causes by the second follow-up. Despite some methodological limitations, our findings suggest a more optimistic outlook and the need for longer, more assertive treatment for elderly, depressed patients.
authors.affiliation: Academic Department of Psychogeriatrics, University of New South Wales, Little Bay, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Brodaty
authors.forename: L
authors.initials: L
authors.lastname: Harris
authors.forename: K
authors.initials: K
authors.lastname: Peters
authors.forename: K
authors.initials: K
authors.lastname: Wilhelm
authors.forename: I
authors.initials: I
authors.lastname: Hickie
authors.forename: P
authors.initials: P
authors.lastname: Boyce
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: G
authors.initials: G
authors.lastname: Parker
authors.forename: K
authors.initials: K
authors.lastname: Eyers
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged / Q000523:psychology*; D015331:Cohort Studies; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012737:Sex Factors
chemical_list: D011619:Psychotropic Drugs