title: Sulphonamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.
authors.affiliation: Institute of Chemistry, Pedagogical University of Opole, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Pawełczak
authors.forename: M
authors.initials: M
authors.lastname: Makowski
authors.forename: M
authors.initials: M
authors.lastname: Kempny
authors.forename: J M
authors.initials: JM
authors.lastname: Dzik
authors.forename: M
authors.initials: M
authors.lastname: Balińska
authors.forename: W
authors.initials: W
authors.lastname: Rode
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005493:Folic Acid Antagonists / Q000494:pharmacology* / Q000633:toxicity; D007202:Indicators and Reagents; D007940:Leukemia L5178; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
chemical_list: D005493:Folic Acid Antagonists; D007202:Indicators and Reagents; D013449:Sulfonamides; D013940:Thymidylate Synthase