title: Lack of variation in the nucleotide sequence corresponding to the transmembrane domain of the beta-amyloid precursor protein in Alzheimer's disease.
abstract: The nucleotide sequence corresponding to the APP transmembrane domain and flanking regions of charged amino acids was determined for 91 patients with histologically confirmed Alzheimer's disease, 9 patients with dementias of other etiologies, and 14 controls who had no identifiable brain disease. Twenty-eight of the AD patients had a first-degree relative with dementia. No mutations were detected among the 100 demented patients. However, one of the 14 controls exhibited a change in the 3' base of codon 716 which would not be expected to result in an amino acid substitution at this position.
authors.affiliation: Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213.
authors.forename: G S
authors.initials: GS
authors.lastname: Zubenko
authors.forename: S
authors.initials: S
authors.lastname: Stiffler
authors.forename: J
authors.initials: J
authors.lastname: Farr
authors.forename: U
authors.initials: U
authors.lastname: Kopp
authors.forename: H
authors.initials: H
authors.lastname: Hughes
authors.forename: B B
authors.initials: BB
authors.lastname: Kaplan
authors.forename: J
authors.initials: J
authors.lastname: Moossy
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D000595:Amino Acid Sequence; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry*; D001483:Base Sequence; D005820:Genetic Testing; D014644:Genetic Variation; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D017434:Protein Structure, Tertiary
chemical_list: D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins