title: Case report 797: "Dedifferentiated" lipoma-like liposarcoma of soft tissue with focal transformation to high-grade "sclerosing" osteosarcoma.
abstract: We have presented the first case of a lipoma-like liposarcoma of the soft tissues with high-grade malignant transformation to a high-grade osteosarcoma, the latter component of which responded well to systemic chemotherapy. With 4 months of follow-up the patient is without evidence of disseminated disease. The various types of liposarcoma are listed and several described in some detail. Of particular importance is the potential for development of a highly malignant sarcoma from a relatively indolent low-grade liposarcoma, with even osteosarcoma developing.
authors.affiliation: Division of Orthopedic Oncology, Hospital of the Good Samaritan, Los Angeles, CA 90017.
authors.forename: V
authors.initials: V
authors.lastname: Ippolito
authors.forename: E W
authors.initials: EW
authors.lastname: Brien
authors.forename: L R
authors.initials: LR
authors.lastname: Menendez
authors.forename: J M
authors.initials: JM
authors.lastname: Mirra
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008067:Lipoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D008080:Liposarcoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D012516:Osteosarcoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D013848:Thigh / Q000000981:diagnostic imaging