The mechanism of myocyte death in ischaemia.
Mechanisms of myocyte cell death in severe ischaemia may include: (1) accumulated metabolic products; (2) activation of membrane phospholipases; (3) formation of oxygen-derived free-radicals; (4) infiltration by activated neutrophils; (5) increased circulating catecholamines; (6) cytosolic calcium overload; (7) an inadequate supply of glycolytically produced ATP. The hypothesis is proposed that failure of glycolysis leads to inadequate control of intracellular calcium, which is a lethal event. This hypothesis would explain the concept that in the hibernating myocardium, viable zones can be detected by positron emission tomography of fluoro-deoxyglucose.
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Ischaemic Heart Disease Research Unit, Medical Research Council, Cape Town, South Africa.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D016923:Cell Death; D005609:Free Radicals; D006019:Glycolysis; D006801:Humans; D008213:Lymphocyte Activation; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009504:Neutrophils / Q000276:immunology; D010740:Phospholipases / Q000378:metabolism; D017382:Reactive Oxygen Species
D002395:Catecholamines; D005609:Free Radicals; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D010740:Phospholipases; D002118:Calcium