Effects of thymus humoral factor gamma-2 (THF gamma 2) on lymphohaematopoietic progenitor cells: an in vitro study.
Thymus humoral factor gamma-2 (THF gamma 2), an immunomodulatory factor, was previously shown to exert a regulatory effect upon human haematopoietic development. In the present study, we were primarily interested in determining whether THF gamma 2 has an immunorestorative effect after HIV infection. Although no inhibition of viral production by T-cluster-forming cells and their mature progeny was observed, this thymus-derived compound prevented the dramatic decrease in CD4+ cells observed in cultures of immature T cells from normal bone marrow infected with HIV 1.
Calenda
V
V
INSERM Unité 322, Parc Scientifique et Technologique de Luminy, Marseille, France.
Silvy
F
F
Chermann
J C
JC
D000998:Antiviral Agents / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D009842:Oligopeptides / Q000494:pharmacology*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D013951:Thymus Hormones / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004279:DNA, Viral; D009842:Oligopeptides; D013951:Thymus Hormones; C064563:thymic humoral factor gamma 2