Urinary proteoglycans after cadmium exposure.
The excretion of urinary glycosaminoglycans by five occupationally exposed men with urinary cadmium levels of 1 to 6.5 micrograms/g creatinine did not differ significantly from that of six age-matched non-exposed controls (2.8 +/- 1.8 mg/mmol creatinine vs. 2.3 +/- 1.6 mg/mmol creatinine, +/- S.D.) as analyzed in random urine samples. However, there was a cadmium concentration-dependent increase in the excretion of 50 kD proteoglycan as analyzed by polyacrylamide electrophoresis of the isolated proteoglycan fraction in the same urine samples. This may represent the early dose-dependent effect of cadmium on renal tubules which leads to decrease in the renal cell sialic acid content and protein excretion at higher exposure levels.
Savolainen
H
H
Institute of Occupational Health Sciences, Lausanne, Switzerland.
D000328:Adult; D002104:Cadmium / Q000652:urine; D002105:Cadmium Poisoning / Q000652:urine*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000652:urine*; D011509:Proteoglycans / Q000652:urine*
D011509:Proteoglycans; D002104:Cadmium