GM-CSF and eosinophil chemotactic factors in an acute lymphoblastic leukemia patient with eosinophilia.
We describe a patient with common acute lymphoblastic leukemia associated with blood and cerebrospinal fluid (CSF) eosinophilia. Serum obtained at onset and conditioned medium prepared from T cells obtained at remission stimulated with interleukin-2 contained eosinophil colony stimulating activity (Eo-CSA), which was confirmed to be predominantly GM-CSF. Leukemic cell conditioned medium and serum obtained at remission contained no Eo-CSA. The CSF contained increased eosinophil chemotactic activity, however, this factor was not identified.
Kita
R
R
Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Enokihara
H
H
Nagashima
S
S
Tsunogake
S
S
Yamato
H
H
Saito
K
K
Furusawa
S
S
Shishido
H
H
Fukushima
Y
Y
Fukuda
T
T
D000328:Adult; D002631:Chemotactic Factors, Eosinophil / Q000097:blood*; D004802:Eosinophilia / Q000097:blood* / Q000150:complications; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000150:complications
D002631:Chemotactic Factors, Eosinophil; D016178:Granulocyte-Macrophage Colony-Stimulating Factor