The in vitro effects of ceftibuten on the host defense mechanism.
The in vitro effects of ceftibuten on human polymorphonuclear leukocyte (PMN) chemotaxis, phagocytosis and chemiluminescence were investigated. PMN from healthy adult donors were incubated for 1 h in medium alone or in medium containing increasing concentrations of ceftibuten (4, 8 and 40 times the MIC for Escherichia coli). Up to 40 MIC ceftibuten did not significantly interfere with the function of PMN.
Braga
P C
PC
Department of Pharmacology, School of Medicine, University of Milan, Italy.
Piatti
G
G
Dal Sasso
M
M
Maci
S
S
Blasi
F
F
D000328:Adult; D000077722:Ceftibuten; D002511:Cephalosporins / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects*; D016897:Respiratory Burst / Q000187:drug effects
D002511:Cephalosporins; D000077722:Ceftibuten