title: Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase.
authors.affiliation: Program of Molecular Pharmacology, Memorial Sloan-kettering Cancer Center, New York, NY 10021.
authors.forename: E
authors.initials: E
authors.lastname: Ercikan
authors.forename: M
authors.initials: M
authors.lastname: Waltham
authors.forename: A
authors.initials: A
authors.lastname: Dicker
authors.forename: B
authors.initials: B
authors.lastname: Schweitzer
authors.forename: J R
authors.initials: JR
authors.lastname: Bertino
mesh_terms: D000595:Amino Acid Sequence; D000630:Aminopterin / Q000378:metabolism / Q000494:pharmacology; D003062:Codon; D005493:Folic Acid Antagonists / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007930:Leucine; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology; D016297:Mutagenesis, Site-Directed; D016133:Polymerase Chain Reaction / Q000379:methods; D011743:Pyrimidines / Q000378:metabolism / Q000494:pharmacology; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003062:Codon; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D011994:Recombinant Proteins; D013762:Tetrahydrofolate Dehydrogenase; D007930:Leucine; D000630:Aminopterin; C024530:piritrexim; D008727:Methotrexate