title: Clinical efficacy and morbidity associated with continuous cyclic compared with continuous ambulatory peritoneal dialysis.
abstract: OBJECTIVE
  To assess the clinical efficacy and morbidity of continuous cyclic peritoneal dialysis compared with continuous ambulatory peritoneal dialysis with a Y-connector as renal replacement therapy.
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  All new patients with end-stage renal failure consecutively entering the dialysis program from January 1988 through July 1991 were randomly assigned to receive continuous ambulatory peritoneal dialysis with a Y-connector or continuous cyclic peritoneal dialysis and were followed prospectively.
  
  
  METHODS
  Patient and technique survival, dialysis adequacy, and (infectious) morbidity.
  
  
  RESULTS
  Forty-one patients (median age, 56 years; range, 18 to 86 years) started continuous ambulatory peritoneal dialysis with a Y-connector (follow-up, 688 patient-months), and 41 patients (median age, 54 years; range 21 to 76 years) started continuous cyclic peritoneal dialysis (follow-up, 723 patient-months). The two groups showed no significant differences in adequacy of dialysis (as assessed by blood pressure control and laboratory and neurologic variables) and patient or technique survival. Renal transplant was the primary reason for discontinuing the assigned dialysis technique in both groups. The average number of hospitalizations per patient-year was 1.0 using continuous ambulatory peritoneal dialysis with a Y-connector and 0.6 per patient-year using continuous cyclic peritoneal dialysis (P = 0.02), with a mean duration of 10.8 and 9.6 days per admission, respectively (not significant). Peritonitis occurred significantly less often in those receiving continuous cyclic peritoneal dialysis (0.94 compared with 0.51 episodes per patient-year; P = 0.03). No difference in causative pathogens was observed. Exit site infection rate was 0.38 episodes per patient-year in both groups.
  
  
  CONCLUSIONS
  In an unselected patient group, continuous cyclic peritoneal dialysis was accompanied by significantly lower rates of peritonitis and dialysis-related hospital admission, whereas it was as effective as continuous ambulatory peritoneal dialysis with a Y-connector for patient and technique survival.
authors.affiliation: Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: C W
authors.initials: CW
authors.lastname: de Fijter
authors.forename: L P
authors.initials: LP
authors.lastname: Oe
authors.forename: J J
authors.initials: JJ
authors.lastname: Nauta
authors.forename: J
authors.initials: J
authors.lastname: van der Meulen
authors.forename: H A
authors.initials: HA
authors.lastname: Verbrugh
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
authors.forename: A J
authors.initials: AJ
authors.lastname: Donker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006760:Hospitalization; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000191:economics / Q000295:instrumentation / Q000379:methods; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000191:economics / Q000295:instrumentation / Q000379:methods; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology; D011446:Prospective Studies; D016019:Survival Analysis; D013673:Technology Assessment, Biomedical; D016896:Treatment Outcome