New major histocompatibility complex genes.
The MHC is a region of some 4 megabases that has been studied intensively owing to the large number of diseases that are associated with susceptibility genes within this region of the genome. The total number of genes located within the MHC is now approximately 100, but more can be predicted. Recently identified genes within the MHC include PERB6, a large gene producing multiple transcripts located between HLA-B and TNF, and PERB1, a member of the protein tyrosine kinase-gene family. PERB6 was identified by YAC probing of tissue blots, while PERB1 was identified by genomic sequencing.
Marshall
B
B
Department of Clinical Immunology, Royal Perth Hospital, Western Australia.
Leelayuwat
C
C
Degli-Esposti
M A
MA
Pinelli
M
M
Abraham
L J
LJ
Dawkins
R L
RL
D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D015342:DNA Probes; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D005091:Exons / Q000235:genetics; D015894:Genome, Human; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D009157:Myasthenia Gravis / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis
D015342:DNA Probes; D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases