title: DNA damage and the DNA-activated protein kinase.
abstract: DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that is activated in vitro by DNA fragments. The cellular targets of DNA-PK are nuclear, DNA-binding, regulatory proteins including Sp1, Fos, Jun, Myc, the tumor suppressor protein p53, and RNA polymerase II. These characteristics suggest a role for DNA-PK in coordinating nuclear processes and as a modulator of checkpoint mechanisms activated by DNA damage.
authors.affiliation: Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000.
authors.forename: C W
authors.initials: CW
authors.lastname: Anderson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D013379:Substrate Specificity
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D010455:Peptides; D051747:DNA-Activated Protein Kinase; C497263:PRKDC protein, human; D017346:Protein Serine-Threonine Kinases