On the model controversy for substrate-induced spin-state transition in cytochrome P450: (a new perspective).
Three models have been proposed for substrate-induced spin-state transition in cytochrome P450. These are referred to as two-, three- and four-state models. In this communication the three models are reviewed with respect to their experimental basis and their ability to accommodate the results reported on the effects of substrates on spin-state and reduction of various P450's. In addition, a new perspective is presented.
Narasimhulu
S
S
Harrison Department for Surgical Research, University of Pennsylvania, Philadelphia 19104.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D010084:Oxidation-Reduction; D013379:Substrate Specificity
D003577:Cytochrome P-450 Enzyme System