Function of a human cyclin gene as an oncogene.
The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.
Hinds
P W
PW
Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142.
Dowdy
S F
SF
Eaton
E N
EN
Arnold
A
A
Weinberg
R A
RA
D017500:Adenovirus E1A Proteins / Q000235:genetics; D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002478:Cells, Cultured; D019938:Cyclin D1; D016213:Cyclins / Q000235:genetics*; D003673:Defective Viruses / Q000235:genetics; D005814:Genes, Viral; D005816:Genetic Complementation Test; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D015513:Oncogene Proteins / Q000235:genetics*; D009857:Oncogenes; D051381:Rats; D014162:Transfection
D017500:Adenovirus E1A Proteins; D016213:Cyclins; D015513:Oncogene Proteins; D019938:Cyclin D1