Association of baseline neuropsychological function and progression of illness over 4 years in HIV-seropositive individuals.
The authors conducted a study to examine the association between neuropsychological markers of central nervous system impairment and systemic human immunodeficiency virus (HIV) disease progression in a sample of 64 HIV-positive asymptomatic patients who were followed for a median of 45.6 months. Patients with poorer baseline scores on the Halstead-Reitan Trail-Making A neuropsychological test developed HIV-related systemic symptoms earlier over the study period than patients with the higher scores on the same test (P < 0.05). Subclinical neuropsychological dysfunction in otherwise asymptomatic HIV-infected individuals may be a harbinger of progressive HIV-related immunologic dysfunction.
Silberstein
C H
CH
Department of Psychiatry, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
O'Dowd
M A
MA
Schoenbaum
E E
EE
Friedland
G H
GH
Chartock
P
P
Feiner
C
C
McKegney
F P
FP
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis*; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests