title: Does R67 dihydrofolate reductase possess a proton donor?
authors.affiliation: Department of Biochemistry, University of Tennessee, Knoxville 37996-0840.
authors.forename: J C
authors.initials: JC
authors.lastname: Holland
authors.forename: C E
authors.initials: CE
authors.lastname: Linn
authors.forename: E
authors.initials: E
authors.lastname: DiGiammarino
authors.forename: R
authors.initials: R
authors.lastname: Nichols
authors.forename: E E
authors.initials: EE
authors.lastname: Howell
mesh_terms: D001665:Binding Sites; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D046911:Macromolecular Substances; D008970:Molecular Weight; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D015202:Protein Engineering; D017433:Protein Structure, Secondary; D011815:R Factors; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D046911:Macromolecular Substances; D011994:Recombinant Proteins; D013762:Tetrahydrofolate Dehydrogenase