title: Continuous positive airway pressure by nasal prongs in bronchiolitis.
abstract: Ten infants with evidence of impending respiratory failure from severe bronchiolitis were successfully treated with continuous positive airway pressure (NCPAP) with double nasal prongs. Their mean (SD) age was 6.7 (3.8) months and mean (SD) body weight was 7.1 (2.1) kg. Respiratory assessments were made immediately before and 2 hours after application of NCPAP. Clinical symptoms, signs, and arterial blood gases improved in all patients, with a significant fall in mean (SD) respiratory rate [71 (6) vs. 54 (9) per minute], mean (SD) heart rate (178(9) vs. 154(15) per minute], and mean (SD) partial pressure of arterial carbon dioxide [Paco2; 48.0 (13.9) vs. 42.4 (12.9) mmHg]. There was a significant rise in mean (SD) arterial blood pH [7.33 (0.05) vs. 7.37 (0.05)] and mean (SD) oxygenation ratio [Fio2/Pao2, 155 (25) vs. 175 (22)]. We believe NCPAP is an effective method, with numerous advantages in the treatment of severe bronchiolitis. Early application of NCPAP is suggested to avoid the need for mechanical ventilation.
authors.affiliation: Department of Pediatrics, Veterans General Hospital, National Yang-Ming Medical School, Taipei, Taiwan, Republic of China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Soong
authors.forename: B
authors.initials: B
authors.lastname: Hwang
authors.forename: R B
authors.initials: RB
authors.lastname: Tang
mesh_terms: D001988:Bronchiolitis / Q000628:therapy*; D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D007223:Infant; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration / Q000295:instrumentation / Q000379:methods
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen