The chromaffin cell: paradigm in cell, developmental and growth factor biology.
This article reviews the chromaffin cell in relation to studies that have elucidated fundamental phenomena in cell biology (the molecular anatomy of exocytosis) and developmental neuroscience (the principle of neuropoiesis in the development of the sympathoadrenal cell lineage). A final section addresses growth factor synthesis and storage in chromaffin cells and their implications for the treatment of neurological disorders, such as Parkinson's disease.
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Department of Anatomy and Cell Biology, University of Heidelberg, Germany.
D000818:Animals; D002417:Cattle; D002838:Chromaffin System / Q000166:cytology*; D002864:Chromogranins / Q000502:physiology; D005089:Exocytosis; D005346:Fibroblast Growth Factors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007378:Interleukins / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009414:Nerve Growth Factors / Q000502:physiology; D051381:Rats; D013234:Stem Cells / Q000166:cytology; D015291:Transforming Growth Factors / Q000502:physiology
D002864:Chromogranins; D006133:Growth Substances; D007378:Interleukins; D009414:Nerve Growth Factors; D005346:Fibroblast Growth Factors; D015291:Transforming Growth Factors