Cutaneous necrosis associated with the antiphospholipid syndrome and mycosis fungoides.
The development of extensive cutaneous necrosis in a patient with tumour-stage mycosis fungoides is described. Skin biopsies showed a lymphomatous infiltrate, and thrombosis of dermal blood vessels. Investigation revealed the presence of anticardiolipin antibodies, a lupus anticoagulant, and low free protein S, which contributed to a prothrombotic state. Antiphospholipid antibodies have been detected in non-Hodgkin's lymphoma, but clinical manifestations are uncommon. Such autoantibodies may be produced by neoplastic lymphoid cells. The frequency with which antiphospholipid antibodies occur in mycosis fungoides is currently unknown.
Hill
V A
VA
St John's Dermatology Centre, St Thomas' Hospital, London, U.K.
Whittaker
S J
SJ
Hunt
B J
BJ
Liddell
K
K
Spittle
M F
MF
Smith
N P
NP
D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005546:Forehead; D006801:Humans; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D011701:PUVA Therapy; D017293:Protein S / Q000378:metabolism; D012867:Skin / Q000473:pathology*
D017293:Protein S