Is Helicobacter pylori a causal agent in gastric carcinoma?
The aim of this study is to clarify the relationship between Helicobacter pylori (H. pylori) infection and gastric carcinoma. 94 patients with gastric carcinoma and 111 patients with chronic gastritis were involved in this study. They were classified into 3 age groups: Group A (40 years and under), Group B (41-59), Group C (60 years and over). Serum samples were tested for H. pylori IgG antibodies by ELISA and for pepsinogen (PG) by RIA. The ratio of PG I/PG II was used as a marker for atrophic gastritis. Results were as follows. In the incidence of H. pylori antibodies, there was no significant differences between gastric carcinoma and chronic gastritis in any of the groups. In the quantity of H. pylori antibodies, there was no significant difference between gastric carcinoma and chronic gastritis in any of the groups. The ratio of PG I/PG II was significantly decreased in H. pylori positive cases when compared to H. pylori negative cases in each group with chronic gastritis and group A and B with gastric carcinoma. The ratio of PG I/PG II in gastric carcinoma was significantly lower than that of chronic gastritis. As conclusion, from the point of view of the prevalence of H. pylori, it is suggested that H. pylori is not a direct causal agent in the pathogenesis of gastric carcinoma.
Takahashi
S
S
Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Igarashi
H
H
Ishiyama
N
N
Nakamura
K
K
Masubuchi
N
N
Ozaki
M
M
Saito
S
S
Aoyagi
T
T
Itoh
T
T
Hirata
I
I
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D002908:Chronic Disease; D005756:Gastritis / Q000097:blood / Q000453:epidemiology / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood; D015995:Prevalence; D013274:Stomach Neoplasms / Q000097:blood / Q000453:epidemiology / Q000382:microbiology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D010435:Pepsinogens