Conconavalin A-stimulated bovine T-cell supernatants inhibit growth of Cowdria ruminantium in bovine endothelial cells in vitro.
Conconavalin A-stimulated bovine T-cell supernatants inhibited the growth of Cowdria ruminantium in bovine endothelial cells in vitro but did not affect their entry. This finding represents one mechanism by which T cells may control C. ruminantium multiplication and hence affect the severity of disease.
Mahan
S M
SM
University of Florida/U.S.A.I.D./SADC Heartwater Research Project, Harare, Zimbabwe.
Smith
G E
GE
Byrom
B
B
D000818:Animals; D002417:Cattle; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D016207:Cytokines / Q000494:pharmacology; D016995:Ehrlichia ruminantium / Q000254:growth & development* / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology / Q000382:microbiology; D006357:Heartwater Disease / Q000209:etiology / Q000276:immunology; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines; D003208:Concanavalin A; D007371:Interferon-gamma