title: A dose titration, and an open 6-week efficacy and safety study of desmopressin tablets in the management of nocturnal enuresis.
abstract: The efficacy and safety of 6 weeks of treatment with desmopressin tablets at doses of 200 to 400 micrograms.at bedtime were investigated in 33 children with monosymptomatic nocturnal enuresis. During an initial 1 to 2-week dose titration period 22 patients (67%) became either completely dry or showed improvement, 7 (21%) showed no response and 4 (12%) dropped out of therapy. During tablet treatment 17 patients on 400 micrograms.and 5 on 200 micrograms.at bedtime increased the number of weekly dry nights from 2.0 +/- 1.6 (standard deviation) during a 2-week observation period to 5.2 +/- 1.9 (p < 0.001). During a subsequent 2-week period 40 micrograms.intranasal desmopressin showed a similar overall efficacy, with a mean of 5.4 +/- 1.6 dry nights per week. In addition, intranasal treatment was able to increase the number of dry nights in 2 of the 7 nonresponders to tablet treatment.
authors.affiliation: Institute of Experimental Clinical Research, University of Aarhus, Denmark.
authors.forename: T B
authors.initials: TB
authors.lastname: Matthiesen
authors.forename: S
authors.initials: S
authors.lastname: Rittig
authors.forename: J C
authors.initials: JC
authors.lastname: Djurhuus
authors.forename: J P
authors.initials: JP
authors.lastname: Nørgaard
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage* / Q000627:therapeutic use; D004775:Enuresis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male
chemical_list: D003894:Deamino Arginine Vasopressin