title: Effect of pravastatin on human sleep.
abstract: To evaluate the effect of pravastatin, an HMG-CoA reductase inhibitor, on sleep, the drug or a placebo was administered to 5 healthy adults for 16 days by the double-blind method. Pravastatin caused no changes in sleep parameters. This indicates that it had no effect on human sleep for the following possible reasons: Being hydrophilic, the drug does not readily cross the blood-brain barrier. It does not inhibit prostaglandin D2 synthase, a possible sleep-inducing substance. It was thought that a decrease in the total cholesterol level in the blood has no effect on sleep in healthy adults.
authors.affiliation: Department of Neuropsychiatry, Yamanashi Medical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kamei
authors.forename: S
authors.initials: S
authors.lastname: Shirakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ishizuka
authors.forename: A
authors.initials: A
authors.lastname: Usui
authors.forename: M
authors.initials: M
authors.lastname: Uchiyama
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Fukuzawa
authors.forename: T
authors.initials: T
authors.lastname: Kariya
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000187:drug effects; D017035:Pravastatin / Q000494:pharmacology*; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D002784:Cholesterol; D017035:Pravastatin