Short chain fatty acid-induced hyperventilation is due to PGF2-alpha.
While studying the significance of the short chain fatty acids (SCFAs) in the pathogenesis of hyperventilation, we have found that experimental rabbits injected with SCFA sodium salt (4 mmol/kg b.wt) develop hyperventilation 20 min later. This hyperventilation results in a decrease of PCO2 in the arterial blood from 32.05 +/- 1.18 to 24.55 +/- 0.83 (p < 0.001). The SCFAs also bring about pronounced mixed alkalosis. The prostaglandin F2-alpha (PGF2-alpha) in both the arterial and venous blood of rabbits increased significantly after treatment with SCFAs salts. If the rabbits are pretreated with indomethacin (10 mg/kg), the SCFAs do not cause hyperventilation. Therefore we can conclude, that the SCFAs bring about hyperventilation through an increase in the PGF2-alpha synthesis.
Mitkov
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Department of Pathophysiology, Faculty of Medicine, Plovdiv, Bulgaria.
D000471:Alkalosis / Q000209:etiology; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D015237:Dinoprost / Q000096:biosynthesis / Q000502:physiology*; D005227:Fatty Acids / Q000633:toxicity*; D006985:Hyperventilation / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control; D016857:Hypocapnia / Q000209:etiology; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011817:Rabbits
D005227:Fatty Acids; D002245:Carbon Dioxide; D015237:Dinoprost; D010100:Oxygen; D007213:Indomethacin