Synthesis and nonthrombogenicity of fluoroalkyl polyetherurethanes.
New polyetherurethanes carrying fluoroalkyl substituents in the side chains were synthesized from N,N-di(hydroxyethyl)heptadecafluorooctyl-sulfonamide (a chain extender), 4,4'-disocyanatodiphenylmethane, and poly(tetramethylene glycol). Various kinds of polyetherurethanes having different tensile properties were prepared by changing the content of fluoroalkyl chain extender or the molecular weight of poly(tetramethylene glycol). The surface of a film made from the fluoroalkyl polyetherurethane was strongly water-repulsive. The in vitro thrombus formation on the fluoroalkyl polyetherurethanes was reduced by increasing the content of chain extender for the same molecular weight of poly(tetramethylene glycol). Protein adsorption, platelet adhesion, and platelet activation on the fluoroalkyl polyetherurethanes were also investigated.
Kashiwagi
T
T
Department of Polymer Chemistry, Kyoto University, Japan.
Ito
Y
Y
Imanishi
Y
Y
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D001777:Blood Coagulation / Q000187:drug effects*; D001798:Blood Proteins / Q000187:drug effects; D004285:Dogs; D015539:Platelet Activation / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship; D013718:Tensile Strength
D001672:Biocompatible Materials; D001798:Blood Proteins; D011140:Polyurethanes