title: Effects of a novel melatonin analog on circadian rhythms of body temperature and activity in young, middle-aged, and old rats.
abstract: Circadian rhythms of body temperature and activity were recorded in young, middle-aged, and old rats. A new melatonin analog, S20242, was administered daily around the onset of darkness for a 2-week period. Compared to the young animals, there was a significant age-related reduction in the amplitude and stability of body temperature and activity in both the middle-aged and old rats. In these two groups there was an improvement of the circadian rhythm of body temperature as a result of daily application of the melatonin analog.
authors.affiliation: Netherlands Institute for Brain Research, Amsterdam.
authors.forename: G C
authors.initials: GC
authors.lastname: Koster-van Hoffen
authors.forename: M
authors.initials: M
authors.lastname: Mirmiran
authors.forename: N P
authors.initials: NP
authors.lastname: Bos
authors.forename: W
authors.initials: W
authors.lastname: Witting
authors.forename: P
authors.initials: P
authors.lastname: Delagrange
authors.forename: B
authors.initials: B
authors.lastname: Guardiola-Lemaitre
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011914:Rats, Inbred BN
chemical_list: D008550:Melatonin