Ocular renin angiotensin: EM immunocytochemical localization of prorenin.
Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, particularly in the vitreous cortex. This observation adds further evidence to a role of the ciliary epithelium in the transfer, storage or synthesis of components of a putative ocular renin angiotensin system.
Wallow
I H
IH
Department of Ophthalmology and Visual Science, University of Wisconsin, Madison.
Sramek
S J
SJ
Bindley
C D
CD
Darjatmoko
S R
SR
Gange
S J
SJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002924:Ciliary Body / Q000378:metabolism* / Q000648:ultrastructure; D004792:Enzyme Precursors / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D012083:Renin / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology*
D000911:Antibodies, Monoclonal; D004792:Enzyme Precursors; D012083:Renin