title: Neonatal testis tumors: a review of the Prepubertal Testis Tumor Registry.
abstract: Since 1980, 338 testis tumors have been registered in the Prepubertal Testis Tumor Registry of the American Academy of Pediatrics, Section on Urology. Of these tumors 22 occurred in neonates less than 1 month old, of which 7 (31%) were diagnosed at birth. The distribution of lesions in this group revealed 6 yolk sac tumors, 6 gonadal stromal tumors, 6 juvenile granulosa cell tumors, 2 gonadoblastomas, 1 teratoma and 1 hamartoma. Preoperative serum alpha-fetoprotein levels were available for 10 patients and ranged from 23 to 61,700 ng/ml., which is within normal limits. No patient had evidence of metastatic disease at presentation. Of the 18 children in whom follow up is available 17 have no evidence of disease and 1, who was diagnosed with a yolk sac tumor before the advent of chemotherapy, died of metastatic disease before reaching age 1 year. Although neonatal testis tumors are rare, they should be considered in the differential diagnosis and management of a newborn with a scrotal mass.
authors.affiliation: Department of Urology, Case Western Reserve University, Cleveland, Ohio 44195.
authors.forename: D A
authors.initials: DA
authors.lastname: Levy
authors.forename: R
authors.initials: R
authors.lastname: Kay
authors.forename: J S
authors.initials: JS
authors.lastname: Elder
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012042:Registries; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000628:therapy