Elatosides A and B, potent inhibitors of ethanol absorption in rats from the bark of Aralia elata Seem: the structure-activity relationships of oleanolic acid oligoglycosides.
By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata Seem. together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Harada
E
E
Matsuda
H
H
Murakami
T
T
Yamahara
J
J
Murakami
N
N
D000042:Absorption / Q000187:drug effects; D000427:Alcohol Deterrents / Q000737:chemistry* / Q000302:isolation & purification; D000437:Alcoholism / Q000188:drug therapy; D000818:Animals; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009828:Oleanolic Acid / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000427:Alcohol Deterrents; D010936:Plant Extracts; D000431:Ethanol; D009828:Oleanolic Acid