The effect of indomethacin upon cerebral blood flow in healthy volunteers. The influence of moderate hypoxia and hypercapnia.
In a randomized study of healthy volunteers indomethacin bolus injection followed by continuous infusion decreased CBF from normal levels ranging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/100 g/min. These low levels were sustained during a six hour infusion period. Periods of hypoxia during inhalation of 17% oxygen and hypercapnia during inhalation of 2-4% CO2 normalized CBF.
Jensen
K
K
Department of Anesthesiology Hjørring Municipal Hospital, Denmark.
Freundlich
M
M
Bünemann
L
L
Therkelsen
K
K
Hansen
H
H
Cold
G E
GE
D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D010100:Oxygen / Q000097:blood*
D002245:Carbon Dioxide; D010100:Oxygen; D007213:Indomethacin