A novel chromosomal abnormality detected in a case of acute myelomonocytic leukemia.
A not yet recorded translocation, t(3:17)(q21;q23), detected in a case of acute myelomonocytic leukemia, is reported. In spite of an aggressive cytotoxic chemotherapy, the disease showed a rapid fatal course, confirming the dismal prognostic significance of structural, 'primary' chromosomal abnormalities in acute leukemias.
Fiorillo
A
A
Department of Pediatrics, University Federico II, Naples, Italy.
Sebastio
L
L
Del Vecchio
L
L
Migliorati
R
R
De Chiara
C
C
D'Amore
R
R
Vicari
L
L
Pastore
A
A
Selleri
C
C
D002886:Chromosomes, Human, Pair 17; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D007223:Infant; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D011379:Prognosis; D014178:Translocation, Genetic