Antimicrobial activity of cytotoxic drugs may influence isolation of bacteria and fungi from blood cultures.
The potential antimicrobial activity of cyclophosphamide, vincristine, and adriamycin against Gram positive and negative bacteria and Candida albicans was examined. The time taken for different microbial inocula to turn a simulated blood culture positive in the presence of different concentrations of these drugs was measured. Doxorubicin retarded the growth of Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus sanguis in a concentration dependent manner. Cyclophosphamide and vincristine showed minimal antimicrobial activity. Escherichia coli and Pseudomonas aeruginosa were unaffected by any of the drugs. An inoculum dependent effect was seen with some combinations of microbial inocula and cytotoxic drug concentrations.
Peiris
V
V
Department of Microbiology, Withington Hospital, Manchester.
Oppenheim
B A
BA
D001419:Bacteria / Q000187:drug effects*; D001431:Bacteriological Techniques; D002176:Candida albicans / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013298:Streptococcus sanguis / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide