[Structure and organization of class I interferon molecules].
The regular structure of class I interferon molecules was proposed using the new method of protein structure investigation--the comparative analysis of amino acids codon roots. It was found out that IFN-alpha and IFN-omega molecules are formed of 5 repeats. Each repeat can be divided into two parts or blocks with regular (alpha-spiral, block A) and irregular (parts of molecules between alpha-spirals, block B) structures. Localization of blocks A and B in IFN-alpha molecules has good correlation with the models of secondary structure organization of IFN-alpha. It is supposed that such a structure of IFN molecules is formed in the evolution process as a result of multiplication of IFN primary gene.
Tsilinskis
E E
EE
Ievinia
N G
NG
Chipens
G I
GI
D000595:Amino Acid Sequence; D003062:Codon; D007370:Interferon Type I / Q000737:chemistry* / Q000235:genetics; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D012091:Repetitive Sequences, Nucleic Acid; D013329:Structure-Activity Relationship
D003062:Codon; D007370:Interferon Type I
Struktura i organizatsiia molekul interferonov I klassa.