Immunoglobulin-secreting cells in primary immunodeficiency diseases.
To assess immunoglobulin production in vivo, the numbers of immunoglobulin-secreting cells were measured in uncultured peripheral blood mononuclear cells (PBMCs) of patients with primary immunoglobulin deficiency. The numbers of immunoglobulin-secreting cells were found to be variable, and they were well correlated with the serum concentrations of all three major immunoglobulin classes. Our results suggest that measurement of immunoglobulin-secreting cells in PBMCs is useful in the assessment of the ability to produce immunoglobulin in vivo.
Kondo
N
N
Department of Pediatrics, Gifu University School of Medicine, Japan.
Shinoda
S
S
Li
G P
GP
Kato
Z
Z
Orii
T
T
D000921:Antibody-Producing Cells; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*
D007136:Immunoglobulins