Ablation of luteal phase symptoms of Menière's disease with leuprolide.
Symptoms of Menière's disease in women may be exacerbated during the luteal phase of the menstrual cycle. This suggests a role for progesterone production and subsequent fluid redistribution as a predisposing factor for Menière's symptoms. We report the use of leuprolide acetate, a gonadotropin-releasing hormone agonist, in a woman with cyclic Menière's symptoms. This drug, which abolishes gonadotropin-dependent ovarian sex steroid production, alleviated the patient's symptoms during therapy. This observation offers further support to the hypothesis of sex hormone-related exacerbations of Menière's symptoms and provides a possible future treatment option for this debilitating disease.
Price
T M
TM
Department of Obstetrics and Gynecology, Greenville Hospital System, SC.
Allen
T C
TC
Bowyer
D L
DL
Watson
T A
TA
D000328:Adult; D005260:Female; D012739:Gonadal Steroid Hormones / Q000037:antagonists & inhibitors; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology / Q000627:therapeutic use*; D008183:Luteal Phase / Q000187:drug effects / Q000502:physiology*; D008575:Meniere Disease / Q000188:drug therapy* / Q000503:physiopathology*
D012739:Gonadal Steroid Hormones; D016729:Leuprolide