title: Evoked potentials in the evaluation of patients with mitochondrial myopathy.
abstract: Multimodality evoked potentials and pattern electroretinograms (PERGs) were performed in seventeen patients with histologically defined mitochondrial myopathy (MM). Brainstem auditory evoked potentials showed abnormalities in 47% and somatosensory evoked potentials in 76%. Visual evoked potentials were outside the normal range in 71%; PERGs exhibited a decreased amplitude or delayed P50 in 78%. These findings may be considered as an expression of impairment of the central nervous system in MM, even if the specific mechanism, 'structural' or 'functional', needs further investigation.
authors.affiliation: Department of Clinical Neurophysiology, University of Pisa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Sartucci
authors.forename: B
authors.initials: B
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Tognoni
authors.forename: G
authors.initials: G
authors.lastname: Siciliano
authors.forename: V
authors.initials: V
authors.lastname: Guerrini
authors.forename: L
authors.initials: L
authors.lastname: Murri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology; D002872:Chromosome Deletion; D004272:DNA, Mitochondrial / Q000235:genetics; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004576:Electromyography; D004596:Electroretinography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000502:physiology; D017237:Mitochondrial Encephalomyopathies / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D017240:Mitochondrial Myopathies / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial