Dual photon absorptiometry for bone mineral measurements using a gamma camera.
A gamma camera was equipped with a special collimator and arm assembly for bone mineral measurements with dual photon absorptiometry (DPA). The system was evaluated in vitro and in vivo and compared both with a rectilinear DPA and a dual energy X-ray (DEXA) system. All 3 systems showed a linear response in measurements of 4 vials, containing different amounts of hydroxyapatite. Phantom measurements with the gamma camera system showed a precision of 1.6% to 2.8%. Results obtained in 8 healthy volunteers with rectilinear and gamma camera systems were well correlated (R2 = 0.78). With the photon beam directed from posterior to anterior, the separation of vertebrae was easy with the gamma camera system. We conclude that bone mineral measurements can be made with a gamma camera for assessment of fracture risk and in the decision process whether a patient needs treatment or not. For follow-up, the precision of DPA with a gamma camera is inadequate.
Valkema
R
R
Department of Radiology and Nuclear Medicine, University Hospital, Leiden, The Netherlands.
Prpic
H
H
Blokland
J A
JA
Camps
J A
JA
Papapoulos
S E
SE
Bijvoet
O L
OL
Pauwels
E K
EK
D015502:Absorptiometry, Photon / Q000295:instrumentation*; D000328:Adult; D015519:Bone Density; D004867:Equipment Design; D005260:Female; D005682:Gadolinium; D015902:Gamma Cameras; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008961:Models, Structural; D011868:Radioisotopes; D011877:Radionuclide Imaging
D011868:Radioisotopes; D005682:Gadolinium