Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease.
Among 23 patients with Alzheimer's disease, 11 (48%) exhibited cortisol hypersecretion (> or = 11.8 micrograms/dl) and nine (39%) displayed cortisol nonsuppression on the dexamethasone suppression test. Only four patients exhibited both neuroendocrine abnormalities, demonstrating a lack of association between these two neuroendocrine disturbances of over 50%. Twenty-two of the 23 patients were studied for 4 1/2 years, and 14 died during that period. Six of the eight surviving patients exhibited cortisol hypersecretion without cortisol nonsuppression.
Miller
A H
AH
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.
Sastry
G
G
Speranza
A J
AJ
Lawlor
B A
BA
Mohs
R C
RC
Ryan
T M
TM
Gabriel
S M
SM
Serby
M
M
Schmeidler
J
J
Davis
K L
KL
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis*; D003907:Dexamethasone; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male
D003907:Dexamethasone; D006854:Hydrocortisone