title: Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2).
abstract: Peripheral myelin protein 2 (PMP2) is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. In this paper, we describe the cloning, characterization, and chromosomal mapping of the human PMP2 gene. The gene is about 8 kb long and consists of four exons. All exon-intron junction sequences conform to the GT/AG rule. The 5'-flanking region of the gene has a TA-rich element (TATA-like box) and a single defined transcription initiation site detected by the primer extension method. The gene for human PMP2 was assigned to chromosome 8q21.3-q22.1 by spot hybridization of flow-sorted human chromosomes and fluorescence in situ hybridization.
authors.affiliation: Department of Pediatrics and Dentistry, Akita University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hayasaka
authors.forename: M
authors.initials: M
authors.lastname: Himoro
authors.forename: G
authors.initials: G
authors.lastname: Takada
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Minoshima
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D001483:Base Sequence; D002898:Chromosomes, Human, Pair 8; D003001:Cloning, Molecular; D004247:DNA; D005091:Exons; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D008969:Molecular Sequence Data; D009185:Myelin Proteins / Q000235:genetics*; D015183:Restriction Mapping; D016385:TATA Box; D014158:Transcription, Genetic
chemical_list: D009185:Myelin Proteins; D004247:DNA