title: [Effect of enalapril on left ventricular hypertrophy and left ventricular function in patients with hypertension].
abstract: The aim of this study was to study the effect of enalapril (E) on left ventricular (LV) mass, LV function and blood renin-angiotensin (RA) in patients with hypertension. Sixteen hypertensives were included in this study (WHO I 8, WHO II 8, 49.5 +/- 10.5 yrs). They were examined for blood pressure and heart rate. Chest X-ray film, echocardiography (echo), X-ray computed tomography (CT) and RA before and after about 6 months of E administration were studied. The LV mass was calculated by CT. The LV function was measured by echo. RAS was unchanged during this study. LV mass was significantly reduced after E (121.4 +/- 25.6 vs 104.6 +/- 13.7 g/cm2). The LV systolic function was unchanged after E, but LV diastolic function improved. It was shown that the long-term administration of E improves LV hypertrophy and LV diastolic function without any change of RAS.
authors.affiliation: Department of Cardiovascular Medicine, Hokkaido University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Kakinoki
authors.forename: S
authors.initials: S
authors.lastname: Takechi
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: I
authors.initials: I
authors.lastname: Sakuma
authors.forename: A
authors.initials: A
authors.lastname: Nomura
authors.forename: A
authors.initials: A
authors.lastname: Kitabatake
authors.forename: H
authors.initials: H
authors.lastname: Yasuda
mesh_terms: D000328:Adult; D004656:Enalapril / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System / Q000187:drug effects; D014057:Tomography, X-Ray Computed; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D004656:Enalapril