Phloridzin and phloretin inhibition of 2-deoxy-D-glucose uptake by tumor cells in vitro and in vivo.
Utilizing the rat mammary adenocarcinoma and Fischer bladder cell carcinoma cell lines, this study demonstrated the ability of two known glucose transport inhibitors, phloridzin (P1) and its aglucone, phloretin (P2), to block glucose transport into whole viable tumor cells in vitro and tumor tissues in vivo. This work represents the first in a series of experiments designed to explore the efficacy of P1 and P2 administration in restraining tumor cell growth via the inhibition of glucose transmembrane transport.
Nelson
J A
JA
Institute of Medical Sciences, University of Toronto, Ontario, Canada.
Falk
R E
RE
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D015153:Blotting, Western; D002295:Carcinoma, Transitional Cell / Q000378:metabolism*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism*; D005260:Female; D051274:Glucose Transporter Type 3; D007700:Kinetics; D008223:Lymphoma / Q000378:metabolism; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D012515:Mast-Cell Sarcoma / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000032:analysis / Q000096:biosynthesis; D009419:Nerve Tissue Proteins; D010693:Phloretin / Q000494:pharmacology*; D010695:Phlorhizin / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
D000970:Antineoplastic Agents; D051274:Glucose Transporter Type 3; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; C495690:Slc2a3 protein, rat; D003847:Deoxyglucose; D010695:Phlorhizin; D010693:Phloretin