Concurrent acute exercise alters central and peripheral responses to physostigmine.
This study reports the modulatory effects of physostigmine (Phy) and concurrent acute exercise on the time course of cholinesterase (ChE) activity, the rate of decarbamylation (Kd), and half-time of recovery of ChE in red blood cells (RBC) and various tissues of rats. Acute exercise equivalent to 80% VO2-max (maximal oxygen consumption) transiently increased the RBC ChE activity, whereas Phy decreased ChE activity in RBC and various tissues. Physostigmine along with concurrent acute exercise increased the Kd in RBC, brain, and heart by 56.4%, 66.7%, and 139%, respectively, compared to Phy alone. The Kd in diaphragm and muscle decreased to 14.1% and 56.2%, respectively, compared to Phy alone. The variation in Kd might be due to the effect of concurrent acute exercise on the redistribution of Phy in various tissues of rat as a result of changes in blood flow.
Dube
S N
SN
Southern Illinois University, School of Medicine, Department of Pharmacology, Springfield 62794-9230.
Somani
S M
SM
Babu
S R
SR
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002802:Cholinesterases / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion / Q000502:physiology*; D010830:Physostigmine / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012132:Respiratory Muscles / Q000187:drug effects / Q000201:enzymology
D010830:Physostigmine; D002802:Cholinesterases