[Effect of tocopherol, its analogs and the antioxidant ionol on lipid peroxidation in vitro].
Ionol, alpha-tocopherol and its analogues (tocoferenquinones with C6 and C1 in the side chain, tocopherol without the side chain and two tocopherols with shortened to C6 side chain both with saturated and with unsaturated bond at the end) were studied for their effect on the formation rate of malonaldehyde in the tissue and liver mitochondria of vitamin E-deficient rats in vitro. Preparations were used in two concentrations: 35 mg per 1 ml of the medium--in a dose suppressing processes or lipid peroxidation; and 5 mg per 1 ml of the medium--in a dose activating biosynthesis of ubiquinone in the animal tissues. Tocopherol effect on lipid peroxidation processes in the liver tissue and mitochondria is shown to be different and to depend on its concentration in the medium. Ionol is efficient only in high doses under the conditions in vitro. Tocopherol analogues (their side chain being shortened to six carbon atoms) display maximum activity when they inhibit lipid peroxidation both in the liver tissue and mitochondria in the both concentrations under study which supposes their high efficiency under the conditions in vivo.
Kuz'menko
I V
IV
Kunitsa
N I
NI
Donchenko
G V
GV
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D051381:Rats; D014451:Ubiquinone / Q000096:biosynthesis; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000503:physiopathology
D014451:Ubiquinone; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde
Vliianie tokoferola, ego analogov i antioksidanta ionola na perekisnoe okislenie lipidov in vitro.