Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in northern India.
Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.
Mehra
N K
NK
Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.
Pande
I
I
Taneja
V
V
Uppal
S S
SS
Saxena
S P
SP
Kumar
A
A
Malaviya
A N
AN
D000293:Adolescent; D000328:Adult; D002648:Child; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D007194:India / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D008285:Major Histocompatibility Complex
D006680:HLA Antigens