A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region.
A novel human gene (sazD) that maps to the autosomal dominant polycystic kidney disease region shares sequence similarity with members of the beta-transducin superfamily. The cDNA sazD-c predicts an approximately 58-kDa protein (sazD) with seven internal repeats, similar to the WD-40 motif of the transducin family. The size of this protein family has been expanding rapidly; however, neither the structure nor the function of this repeated motif is known. Preliminary data do not suggest that sazD is mutated in patients with polycystic kidney disease.
Weinstat-Saslow
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DL
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.
Germino
G G
GG
Somlo
S
S
Reeders
S T
ST
D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D016384:Consensus Sequence; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D009154:Mutation; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D015293:Transducin / Q000235:genetics*
D015293:Transducin