[Methylation of DNA in tissue of ovarian malignant tumors in women].
DNA methylation level from woman ovarian malignant tissues was investigated by 32P postlabeling of the single nucleotides, separation on TLC with followed autoradiography and Cerenkov counting. Slight differences in DNA methylation extent were found in malignant ovarian tumors as compared to normal myometrium and benign uterine tumor [myomas]. Lowest level of m5dC in relation to C and also in relation to total DNA was found in carcinoma embryonal tissue whereas maximal DNA methylation level was obtained in folliculoma tissue. This preliminary report needs further investigation of particularly genes methylation.
Baranowski
W
W
II Kliniki Ginekologii Operacyjnej AM, Lublinie.
Tomaszewski
J
J
Keith
G
G
D000328:Adult; D002277:Carcinoma / Q000235:genetics; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D008745:Methylation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D012707:Sertoli Cell Tumor / Q000235:genetics
D004273:DNA, Neoplasm
Metylacja DNA w tkankach guzów złośliwych jajnika u kobiet.