Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease.
The present study determined whether [3H]nisoxetine binding to norepinephrine transporter sites would be altered uniformly throughout the locus coeruleus in Alzheimer's disease. A significant decrease (P < 0.01) in [3H]nisoxetine binding was seen in the mid and caudal regions but not in the rostral region of the locus coeruleus. The loss of [3H]nisoxetine binding to norepinephrine transporter sites may be attributed to a loss of norepinephrine transporter sites located on terminals of noradrenergic neurons in the locus coeruleus in Alzheimer's disease.
Tejani-Butt
S M
SM
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104.
Yang
J
J
Zaffar
H
H
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001345:Autoradiography; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D005473:Fluoxetine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008125:Locus Coeruleus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism; D050484:Norepinephrine Plasma Membrane Transport Proteins; D027981:Symporters; D014018:Tissue Distribution
D002352:Carrier Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters; D005473:Fluoxetine; C011386:nisoxetine; D009638:Norepinephrine