[Adaptive response in vivo: reasons for increase of radioresistance in CFU-S].
The data concerning the reasons of CFU-S radioresistance increase after low dose irradiation of mice were obtained; the reparation processes in CFU-S adapted by low dose irradiation were shown to be more active than in intact ones. Colony formation increase was demonstrated to be more pronounced in adapted animals when they had been injected by 50 mcg of synthetic polyribonucleotide PolyI-PolyC two days before irradiation in challenge dose. The thymogen immunomodulator administration to adapted and intact donor animals leads to the increase of colony yield in equal extent.
Semenets
T N
TN
Semina
O V
OV
Poverennyĭ
A M
AM
Deĭgin
V I
VI
Korotkov
A M
AM
Saenko
A S
AS
D000222:Adaptation, Physiological / Q000187:drug effects / Q000528:radiation effects*; D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D004151:Dipeptides; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use; D011070:Poly I-C / Q000494:pharmacology / Q000627:therapeutic use; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000503:physiopathology* / Q000517:prevention & control; D011836:Radiation Tolerance
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; C060736:thymogen; D011070:Poly I-C
Adaptivnyĭ otvet in vivo: prichiny povysheniia rediorezistentnosti KOEc.