Brain and gut neuropeptides in peripheral blood mononuclear cells.
Neuropeptides, initially thought to be common features of gut and brain, are only synthesized in immune cells and modulate immune functions. The presence and possible functions of these peptides in immune cells in both physiological or pathological conditions have been investigated in our laboratory in the last years. Some of the data obtained are reviewed here, and future developments of the field are indicated.
Panerai
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AE
Department of Pharmacology, University of Milano, Italy.
Sacerdote
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P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D000818:Animals; D001921:Brain; D002633:Chemotaxis / Q000187:drug effects; D002766:Cholecystokinin / Q000097:blood / Q000494:pharmacology; D004064:Digestive System; D006261:Headache / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000097:blood; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000494:pharmacology; D001615:beta-Endorphin / Q000097:blood / Q000494:pharmacology
D009479:Neuropeptides; D014660:Vasoactive Intestinal Peptide; D001615:beta-Endorphin; D002766:Cholecystokinin