title: Dengue epidemic in the state of Rio de Janeiro, Brazil: virological and epidemiological aspects.
abstract: Laboratory studies were carried out on 3178 patients with signs and symptoms suggestive of dengue infection from April 1986 to December 1987 in the State of Rio de Janeiro, Brazil. The epidemic had two peaks following the first virus isolation and affected the inhabitants of 17 counties. Both sex and all age groups were affected. Dengue virus type 1 was isolated from 1039 sera and the number of confirmed cases was increased to 1874 (59%) by MAC-ELISA. Isolation rate confirmed cases reached 80% in the specimens obtained until the 4th day after the onset of disease and viraemia ranged from 10(3.0) to 10(8.5) TCID50/ml.
authors.affiliation: Departamento de Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: M P
authors.initials: MP
authors.lastname: Miagostovich
authors.forename: R M
authors.initials: RM
authors.lastname: Nogueira
authors.forename: S M
authors.initials: SM
authors.lastname: Cavalcanti
authors.forename: K B
authors.initials: KB
authors.lastname: Marzochi
authors.forename: H G
authors.initials: HG
authors.lastname: Schatzmayr
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology* / Q000382:microbiology; D003716:Dengue Virus / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012621:Seasons; D017678:Sex Distribution; D013997:Time Factors