Prognostic value of DNA ploidy in primary gastric leiomyosarcoma.
The prognostic value of DNA ploidy was evaluated in 25 patients with primary gastric leiomyosarcoma, using paraffin-embedded archival specimens analysed by DNA flow cytometry. Ploidy patterns were diploid in ten tumours and non-diploid in 15. They did not correlate with clinicopathological features of the lesions such as tumour size and grade or mitotic index. A non-diploid pattern was associated with a significantly reduced patient survival rate (P < 0.05), as was higher tumour grade (P < 0.01). Neither tumour size nor mitotic index correlated with patient survival.
Suzuki
H
H
Second Department of Surgery, Mie University School of Medicine, Tsu City, Japan.
Sugihira
N
N
D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007890:Leiomyosarcoma / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D011003:Ploidies; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality; D013997:Time Factors
D004273:DNA, Neoplasm