[Pharmacokinetic studies on 99mTc-NGA in human].
Two normal subjects and three patients with hepatic disease were intravenously injected each with a single dose of 99mTc-NGA (galactosyl-neoglycoalbumin), a liver receptor imaging agent. The results showed that pharmacokinetics of 99mTc-NGA accorded with the two compartment open model. In the normal subjects, T1/2 alpha and T1/2 beta averaged 1.65 and 19.39 min respectively, indicating a rapid distribution process and a slow elimination process. There were significant differences in pharmacokinetics of 99mTc-NGA between the normal subjects and the patients with hepatic disease, and therefore the relevant parameters are of importance for the evaluation of hepatic function.
Guan
C
C
Chen
Q
Q
Tan
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000418:Albumins / Q000493:pharmacokinetics*; D005260:Female; D006505:Hepatitis / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*
D000418:Albumins; D015609:Organotechnetium Compounds; C036586:technetium Tc 99m neogalactoalbumin