Genotoxicity of tritiated water in human lymphocytes.
The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that beta-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE.
Ribas
G
G
Departament de Genética i de Microbiologia, Facultat de Ciènces, Universitat Autónoma de Barcelona, Cerdanyola de Vallès, Spain.
Carbonell
E
E
Xamena
N
N
Creus
A
A
Marcos
R
R
D001610:Beta Particles; D002453:Cell Cycle / Q000528:radiation effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D012854:Sister Chromatid Exchange / Q000528:radiation effects*; D014316:Tritium
D014316:Tritium