Effects of nitrendipine and lisinopril on blood pressure and sodium excretion in ciclosporin-associated hypertension after heart transplantation.
Hypertension associated with ciclosporin A may be mediated by sodium and volume retention. Therefore, the effects of an antihypertensive therapy (6 weeks) with nitrendipine (10-20 mg twice daily) or lisinopril (10-20 mg once daily) on office blood pressure, 24-hour ambulatory blood pressure, and left ventricular function were evaluated in a randomised, double-blind cross-over trial in patients after heart transplantation. Nitrendipine and lisinopril were equally effective in lowering office and ambulatory systolic and diastolic blood pressures. After an acute sodium load (210 mval/2 h i.v.), sodium excretion was significantly increased during therapy with lisinopril but only slightly during nitrendipine, indicating that angiotensin-converting enzyme inhibition may improve the sodium-retaining state of heart transplant recipients associated with ciclosporin A.
Hartmann
A
A
Department of Cardiology, Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, FRG.
Schwietzer
G
G
Stratmann
D
D
Kaltenbach
M
M
Kober
G
G
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D015924:Blood Pressure Monitors; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy / Q000652:urine; D017706:Lisinopril / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000188:drug therapy / Q000652:urine; D012964:Sodium / Q000652:urine*
D016572:Cyclosporine; D009568:Nitrendipine; D012964:Sodium; D017706:Lisinopril