Russuphelins B, C, D, E and F, new cytotoxic substances from the mushroom Russula subnigricans Hongo.
Five new chlorinated phenyl ethers, russuphelins B (2), C (3), D (4), E (5) and F (6) have been isolated from the mushroom Russula subnigricans Hongo, and their structures were elucidated by spectroscopic and chemical means. Russuphelins B (2), C (3) and D (4) exhibited cytotoxic activity in vitro against P388 leukemia cells.
Takahashi
A
A
Faculty of Pharmaceutical Sciences, Tohoku University, Japan.
Agatsuma
T
T
Ohta
T
T
Nunozawa
T
T
Endo
T
T
Nozoe
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D002733:Chlorophenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D002733:Chlorophenols