title: The China I/CDC strain of Plasmodium malariae in Aotus monkeys and chimpanzees.
abstract: Five Aotus monkeys and two chimpanzees were infected with Plasmodium malariae isolated from a patient who acquired her infection approximately 50 years ago. All animals were splenectomized. The chimpanzees supported the highest parasite densities of 22,271/microliters and 18,544/microliters. Three Aotus monkeys with a previous history of infection with P. vivax had maximum parasite counts of from 1,818/microliters to 2,909/microliters, whereas two monkeys not previously infected had maximum parasite counts of 6,908/microliters. The establishment of new isolates in these animals aides the development of diagnostic probes and the identification of areas of antigenic variation within the species.
authors.affiliation: Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: W E
authors.initials: WE
authors.lastname: Collins
authors.forename: H O
authors.initials: HO
authors.lastname: Lobel
authors.forename: H
authors.initials: H
authors.lastname: McClure
authors.forename: E
authors.initials: E
authors.lastname: Strobert
authors.forename: G G
authors.initials: GG
authors.lastname: Galland
authors.forename: F
authors.initials: F
authors.lastname: Taylor
authors.forename: A L
authors.initials: AL
authors.lastname: Barreto
authors.forename: R R
authors.initials: RR
authors.lastname: Roberto
authors.forename: J C
authors.initials: JC
authors.lastname: Skinner
authors.forename: S
authors.initials: S
authors.lastname: Adams
mesh_terms: D000368:Aged; D000818:Animals; D001029:Aotus trivirgatus / Q000469:parasitology*; D002681:China; D002738:Chloroquine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000469:parasitology*; D008297:Male; D002679:Pan troglodytes / Q000469:parasitology*; D010965:Plasmodium malariae / Q000254:growth & development*; D013156:Splenectomy; D013997:Time Factors; D065227:Transfusion Reaction
chemical_list: D002738:Chloroquine