title: Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS.
abstract: C57/BL/6 mice infected with LP-BM5 MuLV virus developed an AIDS-like disease (MAIDS) with splenomegaly, leukopenia, thrombocytopenia, anemia, decreased numbers of helper/inducer and suppressor/cytotoxic T-cells and decreased production of interferon alpha. We have shown previously that HIV-associated Kaposi's sarcoma tissue contains high levels of prostaglandin E2 (PgE2), and this inhibits interferon synthesis through a cAMP-dependent second-messenger process. In this study we treated groups of MAIDS-infected mice with combinations of pentoxifylline, an agent which increases cAMP and inhibits phosphodiesterases, and sodium meclofenamic acid, a PgE2 inhibitor. Treated mice showed: 1) significantly higher total leukocyte and platelet counts, 2) higher total L3T4+ (helper/inducer) and Lyt-2+ (suppressor-cytotoxic) T-cell population. Pathologic examination also showed significantly less hepatosplenomegaly and lymphadenopathy in animals treated with pentoxifylline and meclofenamic acid. Partly, PgE2-induced suppression of interferon alpha production may mediate expression of retrovirus infection in this murine model of AIDS.
authors.affiliation: Department of Internal Medicine, Buffalo General Hospital, State University of New York.
authors.forename: I
authors.initials: I
authors.lastname: Stadler
authors.forename: K C
authors.initials: KC
authors.lastname: Chadha
authors.forename: S
authors.initials: S
authors.lastname: Nakeeb
authors.forename: C
authors.initials: C
authors.lastname: Toumbis
authors.forename: J
authors.initials: J
authors.lastname: Butsch
authors.forename: N
authors.initials: N
authors.lastname: Mathur
authors.forename: F
authors.initials: F
authors.lastname: Munschauer
authors.forename: A
authors.initials: A
authors.lastname: Vladutiu
authors.forename: S K
authors.initials: SK
authors.lastname: Satchidanand
authors.forename: J L
authors.initials: JL
authors.lastname: Ambrus
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D008297:Male; D008469:Meclofenamic Acid / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D010431:Pentoxifylline / Q000627:therapeutic use*
chemical_list: D008469:Meclofenamic Acid; D010431:Pentoxifylline