title: Preimmune diversification creates a repertoire while somatic hypermutation fine-tunes affinity--implications for the processes of mutation.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: N
authors.initials: N
authors.lastname: Maizels
mesh_terms: D000818:Animals; D000915:Antibody Affinity / Q000235:genetics; D000916:Antibody Diversity / Q000235:genetics*; D001483:Base Sequence; D002645:Chickens / Q000235:genetics* / Q000276:immunology*; D004247:DNA / Q000235:genetics; D005785:Gene Conversion; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation
chemical_list: D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D004247:DNA