[Possible relationship between the cytologic characteristics of mouse leukemia P-388 cells and their sensitivity to rubomycin].
In search for markers of tumor cell resistance to cytostatic drugs, cytologic characteristics were compared of resistant and sensitive to rubomycin variants of mouse P-388 leukemia. Morphocytochemical, morphometrical and cytogenetic investigations were performed as well as measurements of intracellular pH. As shown by the fluorescent test, pH levels in rubomycin-sensitive and resistant subpopulations differed. This fact evidences an important role of intracellular pH in inducing the resistance and revealed some mechanisms of rubomycin-resistant tumor cell selection.
Shestova
O L
OL
Litinskaia
L L
LL
Diagileva
O A
OA
Kotel'nikov
V M
VM
Pogorelov
V M
VM
Kozinets
G I
GI
D000818:Animals; D003584:Cytological Techniques; D003630:Daunorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA
D003630:Daunorubicin
Vozmozhnaia sviaz' mezhdu tsitologicheskimi kharakteristikami opukholevykh kletok leĭkoza P-388 mysheĭ i ikh chuvstvitel'nost'iu k rubomitsinu.