title: Transdermal clonidine for ameliorating post-orchiectomy hot flashes.
abstract: To determine the efficacy of transdermal clonidine for alleviating post-orchiectomy hot flashes, a randomized, double-blind, crossover clinical trial was designed including 70 men with a history of prostate cancer who had undergone a medical or surgical orchiectomy and were suffering from hot flashes. The results of this study demonstrated that clonidine did not significantly decrease hot flash frequency or severity. Future research is necessary to find effective means of alleviating hot flashes in post-orchiectomy patients.
authors.affiliation: Department of Urology, Mayo Clinic, Rochester, Minnesota.
authors.forename: C L
authors.initials: CL
authors.lastname: Loprinzi
authors.forename: R M
authors.initials: RM
authors.lastname: Goldberg
authors.forename: J R
authors.initials: JR
authors.lastname: O'Fallon
authors.forename: S K
authors.initials: SK
authors.lastname: Quella
authors.forename: A W
authors.initials: AW
authors.lastname: Miser
authors.forename: L A
authors.initials: LA
authors.lastname: Mynderse
authors.forename: L D
authors.initials: LD
authors.lastname: Brown
authors.forename: L K
authors.initials: LK
authors.lastname: Tschetter
authors.forename: M B
authors.initials: MB
authors.lastname: Wilwerding
authors.forename: M
authors.initials: M
authors.lastname: Dose
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002979:Climacteric; D003000:Clonidine / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000188:drug therapy
chemical_list: D003000:Clonidine