Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status.
To assess the generality of the hypothesis that murine double-minute-2 (MDM-2) gene amplification complements the absence of p53 mutation during tumor development, we analyzed 143 murine tumors induced by a variety of carcinogenic agents in two different mouse strains. Only three of 143 tumors showed p53 genetic alterations and none showed MDM-2 amplification, indicating the existence of alternative pathways that permit tumor cells to bypass p53-MDM-2 control.
Saez
G T
GT
Department of Pathology, New York University Medical Center, NY 10016.
Oliva
M R
MR
Mangues
R
R
Pellicer
A
A
D000818:Animals; D001483:Base Sequence; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006243:Harderian Gland / Q000187:drug effects / Q000502:physiology; D006965:Hyperplasia; D008223:Lymphoma / Q000139:chemically induced / Q000209:etiology / Q000235:genetics; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D008770:Methylnitrosourea; D051379:Mice; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology / Q000235:genetics*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D051736:Proto-Oncogene Proteins c-mdm2; D013953:Thymus Neoplasms / Q000139:chemically induced / Q000209:etiology / Q000235:genetics
D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D008770:Methylnitrosourea; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2