[Molecular mechanisms of sex steroid-induced growth of cancer cells].
Recent studies have suggested that the growth of sex steroid-dependent cancer is mediated through sex steroid-induced growth factors in an autocrine manner. In order to prove the hypothesis, estrogen-responsive human breast cancer cell lines such as MCF-7 have been used by many investigations. However, these studies have been unable to prove the hypothesis, since estrogen-dependent growth system in serum-free medium could not be established. We established in 1987 an androgen-dependent growth system in a serum-free medium using androgen-dependent mouse mammary cancer cells (SC-3). By use of this androgen-dependent growth system in serum-free medium, we could demonstrate that androgen-dependent growth of SC-3 cells is mediated via an androgen-induced new growth factor in fibroblast growth factor (FGF) family (AIGF; 8th member of FGF family) in an autocrine mechanism.
Matsumoto
K
K
Osaka Medical Center for Maternal and Child Health, Osaka Medical Center for Maternal and Child Health, Japan.
D000595:Amino Acid Sequence; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002455:Cell Division; D016895:Culture Media, Serum-Free; D004967:Estrogens / Q000502:physiology*; D005260:Female; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000502:physiology; D006133:Growth Substances / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000502:physiology*; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology*; D014407:Tumor Cells, Cultured
D000728:Androgens; D016895:Culture Media, Serum-Free; D004967:Estrogens; C496456:FGF8 protein, human; C496457:Fgf8 protein, mouse; D006133:Growth Substances; D009363:Neoplasm Proteins; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors