Effects of physostigmine on local cerebral glucose utilization in the central components of the rat visual system.
The effects of intravenous administration of physostigmine at doses of 0.03, 0.095, or 0.3 mg/kg on local cerebral glucose utilization (LCGU) were determined in 3 structures of the visual system of the rat brain by means of the quantitative 2-[14C]deoxyglucose method. LCGU was increased in the superior colliculus (superficial gray layer), but unchanged in the visual cortex and the lateral geniculate body. To determine whether the observed effect of physostigmine on the superior colliculus depended on input from the retina, the highest dose of physostigmine was administered to rats which had previously been enucleated bilaterally. Enucleation decreased LCGU in the superior colliculus of the animals not treated with physostigmine and blocked the effect of physostigmine on LCGU. The effect of physostigmine in the superior colliculus appears, therefore, to depend on input from the retina.
Grünwald
F
F
Department of Nuclear Medicine, University of Bonn, FRG.
Crane
A
A
Mende
M
M
Suda
S
S
Kennedy
C
C
Pettigrew
K D
KD
Biersack
H J
HJ
Sokoloff
L
L
Kuschinsky
W
W
D000818:Animals; D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D003847:Deoxyglucose; D004305:Dose-Response Relationship, Drug; D015353:Eye Enucleation; D005829:Geniculate Bodies / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000502:physiology; D013477:Superior Colliculi / Q000187:drug effects / Q000378:metabolism; D014785:Vision, Ocular / Q000502:physiology*; D014793:Visual Cortex / Q000187:drug effects / Q000378:metabolism
D001786:Blood Glucose; D003847:Deoxyglucose; D010830:Physostigmine; D005947:Glucose