Skin irritant and tumour promoting extract from the latex of Euphorbia bougheii.
A crude ethylacetate extract was isolated from Euphorbia bougheii by a combination of solvent-solvent and chromatographic methods. The extract exhibited significant skin irritant activity on the mouse ear as well as a tumour promoting activity on the mouse back skin. This indicates that the use of this plant as a medicine must be discouraged since the latex extract causes cancer.
Gundidza
M
M
Department of Pharmacy, Faculty of Medicine, University of Zimbabwe, Mount Pleasant, Harare.
Kufa
A
A
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007840:Latex; D016488:Medicine, African Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000209:etiology*
D007840:Latex; D010936:Plant Extracts