Antineutrophil antibodies in inflammatory bowel disease recognize different antigens.
Anti-neutrophil cytoplasmic antibodies (ANCA) were observed in 31 out of 68 sera (45%) from Ulcerative Colitis (UC) patients and in 13 out of 38 Crohn's Disease (CD) sera (34%). The presence of ANCA was not related to disease activity, nor to the localization of the disease manifestations. By Western Blotting ANCA showed reactivity with either lactoferrin, polypeptides occurring as a doublet of 66/67 kD MW, or polypeptides occurring as a doublet of 63/54 kD MW.
Mulder
A H
AH
Dept. of Clinical Immunology, University Hospital Groningen, The Netherlands.
Broekroelofs
J
J
Horst
G
G
Limburg
P C
PC
Nelis
G F
GF
Kallenberg
C G
CG
D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D015153:Blotting, Western; D003093:Colitis, Ulcerative / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D007781:Lactoferrin / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D007781:Lactoferrin