[Antro-pyloro-bulbar contractibility in diabetics studied by cineradiography. Effect of erythromycin].
We studied antropyloroduodenal contractility in diabetics and the effect of erythromycin IV (100-500 mg) using the non invasive Boiron cineradiographic method analysis. Fourteen diabetics and 22 controls were examined. Four hours after a standard liquid-solid meal, patients drank 250 mL baryum solution. Fluorographic plates (10 x 10 cm) were taken every 2 s during 30 s. Semi-automatic data processing analysis allowed to measure motility parameters including antral (CA) and bulbar (CB) contractility indexes; pyloric opening index (OP), gastric (FG) and bulbar (FB) frequencies. Three types of pylorus behaviour patterns were define: A and B related to antropyloric and antropyloroduodenal coordination respectively and N without coordination. In diabetics, CA, OP and FG were decreased vs controls (P < 0.01) (CA: 65.5 +/- 6.8 vs 83.1 +/- 2.4%; OP: 60.9 +/- 8.7 vs 84.8 +/- 1.9%; FG: 2.42 +/- 0.14 vs 3.08 +/- 0.04 c/min) and antropylorbulbar coordination altered (N was predominant; no bulbar cycles at 3/min). Antral hypocontractility was correlated with autonomic neuropathy. After erythromycin, radiological parameters returned to normal values (CA = 83.0 +/- 2.4%; OP = 86.0 +/- 4.7%; FG = 3.0 +/- 0.16 c/min) and coordination improved type N disappeared and FB = 3 c/min (58%). Cineradiographic analysis is simple, able to show antropylorobulbar contractile abnormalities, to study pharmacological effects, and in diabetics is capable of studying improvement of motility parameters with erythromycin.
Boiron
M
M
Laboratoire de Physiologie, UFR Médecine, Tours.
Danquechin Dorval
E
E
Gameiro
L
L
Alison
D
D
Metman
E H
EH
Rouleau
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002933:Cineradiography / Q000379:methods*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004386:Duodenum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D011706:Pyloric Antrum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D012016:Reference Values; D015203:Reproducibility of Results
D004917:Erythromycin
Etude de la contractilité antro-pyloro-bulbaire chez le diabétique par analyse de cinéradiographies. Effet de l'érythromycine.