A pharmacokinetic interaction between cimetidine or ranitidine and lornoxicam.
Cimetidine 400 mg twice daily significantly increased serum concentrations and reduced apparent oral clearance of lornoxicam 8 mg twice daily in 12 healthy volunteers. Ranitidine 150 mg twice daily produced no significant changes in lornoxicam pharmacokinetics.
Ravic
M
M
Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
Salas-Herrera
I
I
Johnston
A
A
Turner
P
P
Foley
K
K
Rosenow
D E
DE
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D002927:Cimetidine / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011899:Ranitidine / Q000493:pharmacokinetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D002927:Cimetidine; D011899:Ranitidine; C059451:lornoxicam