Induction of aerial mycelium formation in a bld mutant of Streptomyces tendae by borrelidin--a macrolide antibiotic.
In a screening programme for substances with morphogenic effects on the nikkomycin producer strain Streptomyces tendae Tü 901 we identified a metabolite, which induced aerial mycelium formation in the bld mutant Tü 901/S 2566-EM 1. By using a HPLC UV/Vis absorbance spectral library we could confirm that this compound was identical with the macrolide antibiotic borrelidin. 100 ng borrelidin/paperdisc were sufficient to show an evident morphological effect.
Schüz
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Biologisches Institut, LB Mikrobiologie/Antibiotika, Universität Tübingen, FRG.
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides; D009154:Mutation; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols; D018942:Macrolides; C005066:borrelidin