title: Effect of a novel antifolate, N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523), on growth of H35 rat hepatoma and HEPG2 human hepatoma cells.
authors.affiliation: Wadsworth Center for Laboratories and Research, NYS Department of Health, Albany 12201.
authors.forename: M S
authors.initials: MS
authors.lastname: Rhee
authors.forename: J
authors.initials: J
authors.lastname: Galivan
authors.forename: E M
authors.initials: EM
authors.lastname: Tyobeka
authors.forename: M L
authors.initials: ML
authors.lastname: Sherman
authors.forename: A
authors.initials: A
authors.lastname: Rosowsky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D006528:Carcinoma, Hepatocellular; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004273:DNA, Neoplasm / Q000187:drug effects; D003857:Deoxyuridine / Q000378:metabolism; D005493:Folic Acid Antagonists / Q000633:toxicity*; D005998:Glycine / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms; D009952:Ornithine / Q000031:analogs & derivatives* / Q000633:toxicity; D011622:Pterins / Q000633:toxicity*; D011687:Purines / Q000378:metabolism; D051381:Rats; D013938:Thymidine Monophosphate / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D005493:Folic Acid Antagonists; D011622:Pterins; D011687:Purines; C085590:N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine; D013938:Thymidine Monophosphate; D009952:Ornithine; D005998:Glycine; D003857:Deoxyuridine