The use of conformational restriction and molecular modeling techniques in the development of receptor-specific opioid peptide agonists and antagonists.
Schiller
P W
PW
Laboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal, Quebec, Canada.
Nguyen
T M
TM
Weltrowska
G
G
Chung
N N
NN
Lemieux
C
C
Marsden
B J
BJ
Wilkes
B C
BC
D000595:Amino Acid Sequence; D000818:Animals; D015195:Drug Design; D004723:Endorphins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009292:Narcotic Antagonists; D011957:Receptors, Opioid / Q000737:chemistry / Q000187:drug effects*
D004723:Endorphins; D009292:Narcotic Antagonists; D011957:Receptors, Opioid