Classification of senile plaques by three-dimensional analysis.
We evaluated the number of each senile plaque subtype in Alzheimer's brain by the usual two-dimensional analysis using a single, methenamine silver stained section and three-dimensional analysis using serial section reconstruction. The number of classic plaques was underestimated due to a lack of precision in the usual evaluating procedures (two-dimensional analysis), while that of stellate deposits was overestimated. From these results, it was suggested that the three-dimensional analysis by gapless serial sections was indispensable to examine and subclassify senile plaques.
Kimura
T
T
Division of Clinical Research, National KIKUCHI Hospital for Mental and Nervous Diseases, Kumamoto, Japan.
Hisano
T
T
Yoshida
H
H
Ueda
K
K
Miyakawa
T
T
D000544:Alzheimer Disease / Q000473:pathology*; D000686:Amyloidosis / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D016501:Neurites / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000145:classification* / Q000473:pathology; D009778:Occipital Lobe / Q000473:pathology*