Flow-injection spectrophotometric determination of piroxicam.
Two flow-injection analysis (FIA) methods are proposed for the determination of piroxicam. The first involves measurement of the UV absorbance of a solution containing the drug, methanol and hydrochloric acid at 332 nm; in the second method a Fe(III)-piroxicam complex is formed in a methanolic medium and the absorbance is measured at 520 nm. In both methods, the peak height is used as a quantitative parameter and piroxicam is determined over the ranges 0.5-15 and 30-500 microgram ml-1, respectively. The methods have been applied to the routine determination of the drug in dosage forms.
Sánchez-Pedreño
C
C
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
Garcia
M S
MS
Albero
M I
MI
Rodriguez
J
J
D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D005290:Ferric Compounds; D017022:Flow Injection Analysis / Q000379:methods*; D010894:Piroxicam / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods*
D004304:Dosage Forms; D005290:Ferric Compounds; D010894:Piroxicam