A microsatellite-based multipoint index map of human chromosome 22.
Utilizing the CEPH (Centre d'Etude du Polymorphism Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map.
Buetow
K H
KH
Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Duggan
D
D
Yang
B
B
Ludwigsen
S
S
Puck
J
J
Porter
J
J
Budarf
M
M
Spielman
R
R
Emanuel
B S
BS
D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D003001:Cloning, Molecular; D004247:DNA; D004276:DNA, Satellite / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D004276:DNA, Satellite; D004247:DNA