title: [Hepatosplenic candidiasis in patients treated for hemato-oncological disorders].
abstract: Hepatosplenic candidiasis is increasingly observed in patients with a haematological malignancy who have received chemotherapy. A case history is described of a male aged 45 who developed symptoms of hepatosplenic candidiasis caused by Candida tropicalis after treatment for acute myeloid leukaemia. The disease is characterized by persistent fever after recovery of the leukopenia induced by the chemotherapy. Echographic and computer-tomographic examination may reveal abscess patterns specific of Candida in the liver. Treatment consists of amphotericin B intravenously or fluconazole orally. Protracted treatment is frequently required.
authors.affiliation: Afd. Inwendige Geneeskunde, Academisch Ziekenhuis Vrije Universiteit, Amsterdam.
authors.forename: S
authors.initials: S
authors.lastname: Zweegman
authors.forename: L
authors.initials: L
authors.lastname: Sibinga
authors.forename: P C
authors.initials: PC
authors.lastname: Huijgens
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000008:administration & dosage; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D008100:Liver Abscess / Q000150:complications* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D013158:Splenic Diseases / Q000382:microbiology
chemical_list: D000666:Amphotericin B; D015725:Fluconazole
vernacular_title: Hepatosplenale candidiasis bij patiënten behandeld wegens hemato-oncologische aandoeningen.