title: GM-CSF and eosinophil chemotactic factors in an acute lymphoblastic leukemia patient with eosinophilia.
abstract: We describe a patient with common acute lymphoblastic leukemia associated with blood and cerebrospinal fluid (CSF) eosinophilia. Serum obtained at onset and conditioned medium prepared from T cells obtained at remission stimulated with interleukin-2 contained eosinophil colony stimulating activity (Eo-CSA), which was confirmed to be predominantly GM-CSF. Leukemic cell conditioned medium and serum obtained at remission contained no Eo-CSA. The CSF contained increased eosinophil chemotactic activity, however, this factor was not identified.
authors.affiliation: Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Kita
authors.forename: H
authors.initials: H
authors.lastname: Enokihara
authors.forename: S
authors.initials: S
authors.lastname: Nagashima
authors.forename: S
authors.initials: S
authors.lastname: Tsunogake
authors.forename: H
authors.initials: H
authors.lastname: Yamato
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Furusawa
authors.forename: H
authors.initials: H
authors.lastname: Shishido
authors.forename: Y
authors.initials: Y
authors.lastname: Fukushima
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
mesh_terms: D000328:Adult; D002631:Chemotactic Factors, Eosinophil / Q000097:blood*; D004802:Eosinophilia / Q000097:blood* / Q000150:complications; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000150:complications
chemical_list: D002631:Chemotactic Factors, Eosinophil; D016178:Granulocyte-Macrophage Colony-Stimulating Factor