title: Risk factors for survival following combined heart-lung transplantation. The first 100 patients.
abstract: As the numbers of heart and lung transplant recipients have increased it has become possible to identify major risk factors for early (within 3 months) and later (after 3 months) death after this procedure. For 100 patients receiving organs between April 1984 and February 1991, and followed up until February 1992, patient characteristics, operative details, and early morbidity were assessed for their effects on early and later deaths. Recipient age, sex, and preoperative diagnosis did not have a significant effect on early (within 3 months) or later death. Positive cytomegalovirus antibody status of donor or recipient conferred greater risk of death within 90 days (odds ratio [OR] = 3.24, P = 0.06). Greater than 2 L blood in the first 24 hr after operation (OR = 6.00, P = 0.05), and ventilation for greater than 24 hr (OR = 4.87, P = 0.006) were significant prognostic indicators of early death. After the first 3 months, the main risk factor for death was rejection in the first 3 months (OR = 1.38 per episode, P = 0.008). Early infection in general and CMV infection in particular were associated with a small increase in risk. This study confirms the importance of matching donor and recipient for CMV and shows that difficulties during operation, reflected in postoperative bleeding and ventilation times increased the chance of early death. Later death was associated with early acute rejection. A detrimental effect of infection, including CMV infection, either does not exist, or is too small to be detected in a study of this size.
authors.affiliation: MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom.
authors.forename: L D
authors.initials: LD
authors.lastname: Sharples
authors.forename: J P
authors.initials: JP
authors.lastname: Scott
authors.forename: C
authors.initials: C
authors.lastname: Dennis
authors.forename: T W
authors.initials: TW
authors.lastname: Higenbottam
authors.forename: S
authors.initials: S
authors.lastname: Stewart
authors.forename: T
authors.initials: T
authors.lastname: Wreghitt
authors.forename: S R
authors.initials: SR
authors.lastname: Large
authors.forename: F C
authors.initials: FC
authors.lastname: Wells
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
mesh_terms: D000206:Actuarial Analysis; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D003586:Cytomegalovirus Infections / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000401:mortality; D016041:Heart-Lung Transplantation / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors