Preliminary experimental evaluation of temporary segmental hepatic venous occlusion: angiographic, pathologic, and scintigraphic findings.
OBJECTIVE
Pigs were used to evaluate temporary segmental hepatic venous occlusion as a means of improving the selective delivery of therapeutic agents within the liver.


METHODS
Hepatic angiography and scintigraphy were performed alone and in combination with hepatic venous occlusion.


RESULTS
Arteriograms obtained during venous obstruction demonstrated a greater number of peripheral arterial branches in the occluded area compared with the nonoccluded areas. A prolonged hepatogram showing hepatofugal opacification of the portal branches was observed in the occluded area. Microscopically, mild congestion of the sinusoids and central veins was seen immediately after 60-minute occlusion, but these changes were not evident 2 hours after balloon deflation. Severe congestion and focal hemorrhage were found in the occluded segment of the liver 2 hours after 90-minute venous occlusion. When the right or left hepatic vein was occluded during hepatic arterial infusion of technetium-99m macroaggregated albumin, there was a significant (P < or = .05) increase in the amount of radioactivity measured in the obstructed segment and a significant (P < or = .05) decrease in that found in the nonoccluded regions.


CONCLUSIONS
These results indicate that temporary segmental hepatic vein occlusion is safe for up to 60 minutes and may be clinically applicable as a means of improving the therapeutic index of agents within the liver when they are administered via concomitant hepatic arterial infusion.
Kanazawa
S
S
Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Wright
K C
KC
Kasi
L P
LP
Charnsangavej
C
C
Wallace
S
S
D000792:Angiography; D000818:Animals; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D010690:Phlebography; D011172:Portography; D011877:Radionuclide Imaging; D013552:Swine; D013668:Technetium Tc 99m Aggregated Albumin
D013668:Technetium Tc 99m Aggregated Albumin