Apolipoprotein E to B ratio: a marker for type III hyperlipoproteinaemia.
Apolipoproteins B and E were determined in 40 patients with type III hyperlipoproteinaemia (familial dysbetalipoproteinaemia) and in 48 patients with other types of hyperlipoproteinaemia matched for cholesterol and triacylglycerols. In type III patients, apolipoprotein E was increased and apolipoprotein B was lower than in other types of hyperlipoproteinaemia. The apolipoprotein E to apolipoprotein B ratio almost completely discriminated between type III and other types of hyperlipoproteinaemia. Assuming a cut-off value of 0.09 for the apolipoprotein E to apolipoprotein B ratio, diagnostic sensitivity was 95% and specificity was 88%. It is concluded that the apolipoprotein E to apolipoprotein B ratio represents the first-line screening quantity of choice for the identification of patients with type III hyperlipoproteinaemia in the clinical laboratory.
März
W
W
Gustav Embden-Zentrum der Biologischen Chemie, J.W. Goethe-Universität, Frankfurt am Main, Germany.
Feussner
G
G
Siekmeier
R
R
Donnerhak
B
B
Schaaf
L
L
Ruzicka
V
V
Gross
W
W
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000032:analysis*; D001057:Apolipoproteins E / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D001055:Apolipoproteins B; D001057:Apolipoproteins E; D015415:Biomarkers