title: Efficacy and safety of a quick drying rubbing type povidone-iodine alcoholic disinfectant solution.
abstract: The efficacy and safety of a quick drying rubbing type disinfectant (HAD Hand Wash) composed of a povidone-iodine (PVP-I) and ethanol were evaluated in the disinfection of transient skin flora on fingers of 30 medical staff of our department. Three millilitres of HAD solution was rubbed onto the hands for three minutes several times a day over a four week period. Bacteriological effects were evaluated twice, on the first day and after four weeks, by the palm stamp method. The rate of colonies sterilized (bacterial reduction rate) after the use of HAD Hand Wash was 86.9 +/- 21.2% (mean +/- SD) on the first measurement, and 91.5% +/- 12.8% at four weeks. Staphylococcus epidermidis was isolated most frequently and this was eradicated in 83.3% of subjects, the bacterial reduction rate 99.7%. Staphylococcus aureus was originally isolated in 14 subjects and was eradicated in 13; the bacterial colony reduction rate was 99.9% showing high antiseptic efficacy. Although the bacterial reduction rate for Bacillus sp. was a rather low, 75.8-100%, this result was not considered problematic from the clinical standpoint. There were no side effects like chapping in spite of an average 104 applications of HAD Hand Wash during the 4-week test period. From these results, HAD Hand Wash was considered highly effective and safe.
authors.affiliation: Second Department of Surgery, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kirita
authors.forename: K
authors.initials: K
authors.lastname: Hamano
authors.forename: T
authors.initials: T
authors.lastname: Ochi
authors.forename: H
authors.initials: H
authors.lastname: Ihara
authors.forename: T
authors.initials: T
authors.lastname: Nishiyama
authors.forename: A
authors.initials: A
authors.lastname: Seshimo
authors.forename: Y
authors.initials: Y
authors.lastname: Yagi
authors.forename: K
authors.initials: K
authors.lastname: Sakakida
mesh_terms: D000985:Antisepsis / Q000379:methods*; D001407:Bacillus / Q000187:drug effects; D000431:Ethanol; D006225:Hand / Q000382:microbiology*; D006235:Hand Disinfection / Q000379:methods*; D006801:Humans; D008505:Medical Staff, Hospital; D011206:Povidone-Iodine / Q000627:therapeutic use*; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D000431:Ethanol; D011206:Povidone-Iodine