title: Extending the use of gonadotropin-releasing hormone agonists: the emerging role of steroidal and nonsteroidal agents.
abstract: OBJECTIVE
  To review and summarize the state of the art as it relates to the long-term application of GnRH agonists (GnRH-a).
  
  
  METHODS
  A retrospective analysis of the available literature and results and an up-to-date review of a rapidly evolving field.
  
  
  CONCLUSIONS
  Although the precise use of long-term GnRH-a therapy (in conjunction with sex steroid add-back therapy) remains unknown, the information provided strongly supports additional studies in this area to achieve a body of promising preliminary data.
authors.affiliation: Hôpital Saint-François d'Assise, Quebec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Lemay
authors.forename: E S
authors.initials: ES
authors.lastname: Surrey
authors.forename: A J
authors.initials: AJ
authors.lastname: Friedman
mesh_terms: D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy; D008599:Menstruation Disturbances / Q000188:drug therapy; D010053:Ovary / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000188:drug therapy
chemical_list: D007987:Gonadotropin-Releasing Hormone