[Effects of intravenous injection of ioversol, a nonionic contrast medium, on circulating blood volume: comparison among different combinations of its dose and volume injected].
Effects on circulating blood volume (CBV) of the intravenous injection of a nonionic contrast medium, ioversol, with various doses were assessed in order to find a way of injection with less effects on systemic circulation. Ioversol was injected as a bolus to 20 mongrel dogs at doses of A: 3.75 ml/kg (n = 8) or B: 2 ml/kg (n = 6) of a solution containing 320 mg iodine per ml, or C: 2 ml/kg (n = 6) of a 240 mgI/ml solution. Colloid oncotic pressure (COP) of the bloods drawn before and 1, 2, 3, 5 min after the injection of ioversol was measured by a needle type osmometer, and changes in CBV were calculated using the COP values. Upon injection of ioversol CBV increased rapidly and then gradually returned to the preinjection levels. The change in CBV induced by ioversol was significantly less than those reportedly induced by an ionic contrant medium, iothalamate, and a nonionic medium, iopamidol, and comparable to that by another nonionic medium, iohexol. The degree of increase in CBV and the blood concentration of ioversol were related to the amount, but not the volume, of ioversol injected. Thus, ioversol proved to be one of the low osmotic nonionic contrast media with less effects on CBV. Furthermore, it is suggested that the amount, rather than volume, of contrast medium should be taken into consideration when the angiography of the patients with reduced cardiac function, children or aged patients is performed in whom the contrast medium-induced CBV expansion needs to be as less as possible.
Sakuma
I
I
Department of Cardiovascular Medicine, Hokkaido University School of Medicine.
Sakuma
K
K
Fukao
M
M
Akaishi
Y
Y
Asajima
H
H
Sato
M
M
Shudo
H
H
Numazawa
K
K
Kakinoki
S
S
Kitabatake
A
A
D000818:Animals; D001810:Blood Volume / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D007275:Injections, Intravenous; D009997:Osmotic Pressure / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000494:pharmacology*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C054871:ioversol