[Comparative study of 20% marine salt and 20% NaCl on circulatory dynamics during hemorrhagic shock in dogs].
This study was conducted to investigate the effect of 20% marine salt as compared with 20% NaCl solution, on the circulatory dynamics in hemorrhagic shock using mongrel dogs. Ten mongrel dogs were randomly divided into two groups. One treated with 20% marine salt, and the other treated with 20% NaCl. Modified Wigger's method was used to induce hemorrhagic shock. Hypotension was kept at 45 mmHg for 45 minutes and then 1.5 ml.kg-1 of 20% marine salt or 20% NaCl was injected intravenously in bolus. Twenty percent marine salt reduced total peripheral resistance and increased cardiac output with statistically significant difference compared with 20% NaCl. There were increases in MAP, PAP and PWP without statistic differences between the two groups. These results suggest that 20% marine salt, including various trace elements, is superior to 20% NaCl in improving cardiac output and TPR during hemorrhagic shock.
Luo
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1st Department of Anesthesiology, Dokkyo University, School of Medicine, Tochigi.
Ogata
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D000818:Animals; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D011897:Random Allocation; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D012623:Seawater; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D012965:Sodium Chloride / Q000494:pharmacology*
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride