Cytomegalovirus infection in two infants with congenital or neonatal solid tumors.
Two infants with fibrosarcoma and rhabdomyosarcoma diagnosed prenatally and at 2 months of age, respectively, and cytomegalovirus (CMV) infection are reported. Concomitant CMV infection was revealed by positive urine culture and/or CMV DNA, and CMV-specific IgM, IgA, and complement-fixing antibodies. The patients, showing very low levels of immune T cells, died at 3 and 8 months of age, respectively. A pathogenic role for CMV in the progression of the tumors is suggested.
Nigro
G
G
Pediatric Institute of La Sapienza University, Rome, Italy.
Bartmann
U
U
Properzi
E
E
Torre
A
A
Schiavetti
A
A
Castello
M
M
D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital* / Q000175:diagnosis; D005354:Fibrosarcoma / Q000150:complications / Q000151:congenital*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012208:Rhabdomyosarcoma / Q000150:complications / Q000151:congenital*