title: A comparison of the metabolic changes after the distal splenocaval and portacaval shunts.
abstract: The distal splenorenal shunt (DSRS) is the recommended procedure for selective variceal decompression, but its use may be limited in patients who have undergone left nephrectomy, those with an anatomically aberrant relationship between the splenic and left renal veins, and those whose preoperative angiographic findings suggest a risk of developing postoperative renal vein hypertension. For these clinical situations, the selective distal splenocaval shunt (DSCS) is a useful alternative to the DSRS. However, the metabolic consequences of the DSCS have not yet been studied in detail and therefore, using a canine model, the metabolic changes following the DSCS and the portacaval shunt (Eck) were compared. The metabolic changes observed following the Eck were hyperammonia and amino acid imbalance, while those following the DSCS were similar to those of the control dogs. In terms of the hepatic adenosine triphosphate level, which reflects hepatic mitochondrial function, the DSCS dogs were also similar to the control dogs. These data suggest that there was no metabolic disadvantage of the DSCS compared to the control.
authors.affiliation: Second Department of Surgery, Hyogo College of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Nishiwaki
authors.forename: A
authors.initials: A
authors.lastname: Nishioka
authors.forename: H
authors.initials: H
authors.lastname: Ashida
authors.forename: Y
authors.initials: Y
authors.lastname: Kotoura
authors.forename: J
authors.initials: J
authors.lastname: Utsunomiya
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000596:Amino Acids / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D004285:Dogs; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000503:physiopathology; D008102:Liver Circulation; D008111:Liver Function Tests; D008930:Mitochondria, Liver / Q000502:physiology; D011167:Portacaval Shunt, Surgical; D011170:Portasystemic Shunt, Surgical
chemical_list: D000596:Amino Acids; D000641:Ammonia; D000255:Adenosine Triphosphate