Further characterization of an animal model of systemic vasculitis.
The demonstration of vasculitis and anti-myeloperoxidase antibodies in the mercuric chloride treated Brown Norway rat provides a useful, though limited, animal model of systemic vasculitis. We describe some preliminary experiments on the effect of transfer of serum from mercuric chloride treated rats and of two forms of immunotherapy: intravenous immunoglobulin and an anti-CD4 antibody. Transfer of serum did not lead to tissue injury and neither of the two forms of therapy proved beneficial in this model.
Qasim
F J
FJ
Department of Medicine, University of Cambridge, England.
Mathieson
P W
PW
Thiru
S
S
Oliveira
D B
DB
Lockwood
C M
CM
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D015704:CD4 Antigens / Q000276:immunology; D004195:Disease Models, Animal; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007167:Immunotherapy; D008627:Mercuric Chloride; D009195:Peroxidase / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN; D014657:Vasculitis / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*
D000906:Antibodies; D001323:Autoantibodies; D015704:CD4 Antigens; D016756:Immunoglobulins, Intravenous; D008627:Mercuric Chloride; D009195:Peroxidase