Acquisition of heme iron by Neisseria meningitidis does not involve meningococcal transferrin-binding proteins.
Similarities in size between hemin-binding protein 1 (HmBP1) and transferrin-binding protein 1 (TBP1) of Neisseria meningitidis suggest that these proteins are functionally homologous. However, a meningococcal mutant lacking the transferrin-binding proteins retained the capacity to acquire iron from heme and hemoglobin. In immunoblots, hyperimmune polyclonal antiserum against TBP1 did not react with HmBP1.
Martel
N
N
Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.
Lee
B C
BC
D000818:Animals; D000907:Antibodies, Bacterial; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002417:Cattle; D006418:Heme / Q000378:metabolism*; D000081062:Heme-Binding Proteins; D006420:Hemeproteins / Q000276:immunology / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007120:Immunochemistry; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism*; D033862:Iron-Binding Proteins; D009154:Mutation; D009345:Neisseria meningitidis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D033863:Transferrin-Binding Proteins
D000907:Antibodies, Bacterial; D002352:Carrier Proteins; D000081062:Heme-Binding Proteins; D006420:Hemeproteins; D006454:Hemoglobins; D033862:Iron-Binding Proteins; D033863:Transferrin-Binding Proteins; D006418:Heme; D007501:Iron