Three fatal drug overdoses involving bupropion.
Bupropion is a "second generation" antidepressant agent structurally related to the phenethylamines. Postmortem toxicology data are presented from three suicidal drug overdoses in which bupropion was detected. In two cases in which bupropion was the major toxicology finding, peripheral blood levels of the parent drug were 4.0 and 4.2 mg/L and total metabolite levels were 15 and 16.6 mg/L. Lethal doses in both cases were estimated by history to be less than 10 g.
Friel
P N
PN
Washington State Toxicology Laboratory, Seattle 98134-2027.
Logan
B K
BK
Fligner
C L
CL
D000293:Adolescent; D000328:Adult; D016642:Bupropion / Q000097:blood / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D013405:Suicide
D016642:Bupropion