Use of medications with potential oral adverse drug reactions in community-dwelling elderly.
Prevalence and indicators of medication use with potential oral health implications among 4,163 people from the Duke Established Populations for Epidemiologic Studies of the Elderly were studied. Medications were grouped into seven potential oral adverse drug reaction (POADR) categories. Eighty percent of participants were taking at least one medication from any of the seven categories. Drugs with the potential to cause xerostomia were taken by 56.1%, abnormal hemostasis by 51.7%, soft tissue reactions by 23.4%, taste changes by 11.0%, alteration in host resistance by 8.7%, gingival overgrowth by 5.0%, and movement disorders by 2.4% of participants. Race-stratified analyses revealed that medication use with any POADR was significantly associated (p < 0.001) with being female for both races. Among nonblacks, being > or = 75 years old was associated with higher POADR use. Blacks who had a dental visit in the previous six months were more likely to take medications with POADR than those who did not. POADR medication use was not related to place of residence. Elderly often take medications with potential oral health impact.
Lewis
I K
IK
Department of Pharmacy Services, Veterans Affairs Medical Center, School of Pharmacy, University of North Carolina, Chapel Hill.
Hanlon
J T
JT
Hobbins
M J
MJ
Beck
J D
JD
D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D016321:Dental Care for Aged / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000706:statistics & numerical data*; D064420:Drug-Related Side Effects and Adverse Reactions; D004409:Dyskinesia, Drug-Induced; D005260:Female; D005886:Gingival Hypertrophy / Q000139:chemically induced; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007484:Iowa; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced* / Q000208:ethnology; D015999:Multivariate Analysis; D009657:North Carolina; D016017:Odds Ratio; D012744:Sex Ratio; D013651:Taste Disorders / Q000139:chemically induced; D044465:White People / Q000706:statistics & numerical data; D014987:Xerostomia / Q000139:chemically induced