title: [Possible relationship between the cytologic characteristics of mouse leukemia P-388 cells and their sensitivity to rubomycin].
abstract: In search for markers of tumor cell resistance to cytostatic drugs, cytologic characteristics were compared of resistant and sensitive to rubomycin variants of mouse P-388 leukemia. Morphocytochemical, morphometrical and cytogenetic investigations were performed as well as measurements of intracellular pH. As shown by the fluorescent test, pH levels in rubomycin-sensitive and resistant subpopulations differed. This fact evidences an important role of intracellular pH in inducing the resistance and revealed some mechanisms of rubomycin-resistant tumor cell selection.
authors.forename: O L
authors.initials: OL
authors.lastname: Shestova
authors.forename: L L
authors.initials: LL
authors.lastname: Litinskaia
authors.forename: O A
authors.initials: OA
authors.lastname: Diagileva
authors.forename: V M
authors.initials: VM
authors.lastname: Kotel'nikov
authors.forename: V M
authors.initials: VM
authors.lastname: Pogorelov
authors.forename: G I
authors.initials: GI
authors.lastname: Kozinets
mesh_terms: D000818:Animals; D003584:Cytological Techniques; D003630:Daunorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA
chemical_list: D003630:Daunorubicin
vernacular_title: Vozmozhnaia sviaz' mezhdu tsitologicheskimi kharakteristikami opukholevykh kletok leĭkoza P-388 mysheĭ i ikh chuvstvitel'nost'iu k rubomitsinu.