Effects of fludrocortisone on sympathetic nerve activity in humans.
Fludrocortisone reduces plasma norepinephrine in healthy humans, but forearm vascular and pressor responses to norepinephrine are potentiated. The effects of fludrocortisone on sympathetic nerve activity in healthy humans are not known. To investigate these effects we evaluated muscle sympathetic nerve activity, heart rate, and arterial pressure in 11 healthy volunteers during three protocols: (1) before and on day 7 of fludrocortisone (0.4 mg/d) treatment with ad libitum diet (n = 6); (2) before and on day 7 of fludrocortisone (0.4 mg/d) or placebo with a 150 mmol/24 h (mEq/24 h) sodium diet (n = 7); and (3) before and on day 2 of fludrocortisone (0.4 mg/d) or placebo with a 150 mmol/24 h (mEq/24 h) sodium diet (n = 4). Placebo did not alter any parameter.(ABSTRACT TRUNCATED AT 250 WORDS)
Mion
D
D
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City.
Rea
R F
RF
Anderson
E A
EA
Kahn
D
D
Sinkey
C A
CA
Mark
A L
AL
D000328:Adult; D001835:Body Weight / Q000187:drug effects; D005438:Fludrocortisone / Q000494:pharmacology*; D005542:Forearm / Q000098:blood supply; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D009132:Muscles / Q000294:innervation; D010953:Plasma Volume / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
D005438:Fludrocortisone