Metacarpophalangeal pattern profile analysis in Brachmann-de Lange syndrome.
We analyzed the metacarpophalangeal pattern profile (MCPP) of 19 individuals with Brachmann-de Lange syndrome (BDLS) and calculated a mean syndrome profile. Fourteen of 19 individuals with BDLS had significant positive correlations which indicated clinical homogeneity. Discriminant analysis of individuals with BDLS compared with a sample of normal individuals produced a correct classification rate of 100% based on a function of 2 MCPP variables that may provide a useful tool for assisting in the diagnosis of BDLS. An average pattern variability index calculated for the BDLS patients was 1.9 indicating an abnormal hand pattern in this syndrome.
Butler
M G
MG
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2578.
Dahir
G A
GA
Gale
D D
DD
Meaney
F J
FJ
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003635:De Lange Syndrome / Q000175:diagnosis / Q000473:pathology*; D016002:Discriminant Analysis; D005260:Female; D006228:Hand Deformities, Congenital / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D008663:Metacarpus / Q000002:abnormalities*