title: Giant cell lesions of the jaws: evaluation of nucleolar organizer regions in lesions of varying behavior.
abstract: To examine whether giant cell lesions of the jaws (GCL) of varying behavior could be separated histologically, a number of GCL were studied using the AgNOR staining technique for nucleolar organizer regions. The mean AgNOR count of mononuclear cells from recurrent lesions (1.73 +/- 0.15) was slightly higher than that of the aggressive lesions (1.54 +/- 0.21) and much higher than that of the non-aggressive/non-recurrent lesions (1.33 +/- 0.14). Similarly, the mean AgNOR count of the multinucleate giant cells of the recurrent lesions (1.52 +/- 0.14) was slightly higher than that of aggressive lesions (1.34 +/- 0.092) and much higher than that of non-aggressive/non-recurrent lesions (1.26 +/- 0.05). Statistical analysis showed a significant difference between the mean number of AgNORS of recurrent lesions and non-recurrent/non-aggressive ones in both the mononuclear and multinuclear population (p < 0.05).
authors.affiliation: Department of Oral Diagnosis and Patient Services, Medical College of Georgia School of Dentistry, Augusta.
authors.forename: S B
authors.initials: SB
authors.lastname: Whitaker
authors.forename: N
authors.initials: N
authors.lastname: Vigneswaran
authors.forename: S D
authors.initials: SD
authors.lastname: Budnick
authors.forename: C A
authors.initials: CA
authors.lastname: Waldron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000473:pathology*; D006101:Granuloma, Giant Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000473:pathology*; D008339:Mandibular Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011379:Prognosis