title: Progesterone reduces sympathetic tone without changing blood pressure or fluid balance in men.
abstract: There is scant information on the effects of progesterone on circulation. Changes in catecholamine levels, blood pressure and transcapillary fluid balance were measured in 12 men before and during administration of natural progesterone (Utrogestan). Before administration, systolic blood pressure was significantly correlated with venous adrenaline (r = 0.67, p = 0.01). There was a significant decrease (p = 0.004) in venous noradrenaline during progesterone administration, and systolic blood pressure was significantly correlated with the arteriovenous difference for noradrenaline (r = 0.66, p = 0.02). Serum progesterone, which attained levels similar to those found in women during the luteal phase, did not significantly alter blood pressure, body weight or intra- to extravascular fluid shift. It is concluded that progesterone may have a direct action by increasing the uptake of noradrenaline from the synaptic cleft or by decreasing the nerve firing rate. Interestingly, the pretreatment finding of a significant correlation between blood pressure and adrenaline was less evident during progesterone administration.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tromsø, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Tollan
authors.forename: P
authors.initials: P
authors.lastname: Oian
authors.forename: S E
authors.initials: SE
authors.lastname: Kjeldsen
authors.forename: I
authors.initials: I
authors.lastname: Eide
authors.forename: J M
authors.initials: JM
authors.lastname: Maltau
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood; D006801:Humans; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009638:Norepinephrine / Q000097:blood*; D011374:Progesterone / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D011374:Progesterone; D009638:Norepinephrine; D004837:Epinephrine