Bacillus subtilis flagellar proteins FliP, FliQ, FliR and FlhB are related to Shigella flexneri virulence factors.
The amino acid sequences of the Bacillus subtilis flagellar proteins, FliP, FliQ, FliR and FlhB, as deduced from their respective nucleotide sequences, were found to share significant homology to the Shigella flexneri Spa24, Spa9, Spa29 and Spa40 virulence proteins, respectively. These proteins are required for the presentation of surface plasmid antigens. These results further support the growing hypothesis that a superfamily of proteins exists for the biosynthesis of supramolecular structures that lie in an external to the cell membrane.
Carpenter
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PB
Department of Biochemistry, Colleges of Liberal Arts and Medicine, University of Illinois, Urbana 61801.
Zuberi
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Ordal
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D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D005407:Flagella / Q000737:chemistry; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012763:Shigella flexneri / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; C085668:FlhB protein, Bacteria; C085248:FliR protein, Bacteria; D008565:Membrane Proteins; C074890:FliP protein, Bacillus; C074891:FliQ protein, Bacteria