title: [The treatment of chronic myeloleukemia with recombinant alfa-2 interferon].
abstract: A trial has been conducted of recombinant alpha 2-interferon (reaferon) used in 32 patients with Ph'[correction of Rh']-positive chronic myeloid leukemia (CML). A chronic stage was in 3, transient in 3 and blast in 1 patients. 25 CML patients were newly diagnosed. The treatment lasted from 2 months to 3 years. Clinicohematological remission was confirmed conventionally and by the degree of Ph'-positive clone reduction. An attempt is made to clarify the mechanism underlying the resistance to reaferon basing on the immunological data (detection of antireaferon neutralizing antibodies). The authors propose a combined treatment (myelosan plus reaferon) of CML which has obvious advantages over myelosan monotherapy.
authors.forename: I
authors.initials: I
authors.lastname: Strozha
authors.forename: V
authors.initials: V
authors.lastname: Petukhov
authors.forename: D
authors.initials: D
authors.lastname: Bondare
authors.forename: G
authors.initials: G
authors.lastname: Feldmane
authors.forename: A
authors.initials: A
authors.lastname: Duks
authors.forename: I
authors.initials: I
authors.lastname: Teilane
authors.forename: I
authors.initials: I
authors.lastname: Medne
authors.forename: M
authors.initials: M
authors.lastname: Mauritsas
authors.forename: L
authors.initials: L
authors.lastname: Grinberga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000097:blood / Q000628:therapy*; D002648:Child; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction
chemical_list: D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
vernacular_title: Lechenie khronicheskogo mieloleĭkoza rekombinantnym al'fa 2-interferonom.