title: Metabolic analysis of latissimus dorsi coupled to a mock circulation.
abstract: A mock circulation system has been used to examine the metabolic and hemodynamic responses of untrained and trained latissimus dorsi muscle in a normal animal model. The metabolic response of untrained latissimus dorsi to differing stimulation regimes runs parallel to its mechanical performance. The ratio of power generated to oxidative capacity (a measure of metabolic efficiency) was maintained to a greater extent in muscle trained for 5 months subjected to specific fatigue tests, falling by only 20% (as opposed to 80% observed in untrained control muscle). This approach to studying metabolic and hemodynamic performance may have relevance when skeletal muscle is used for cardiac assistance.
authors.affiliation: Department of Cardiac Surgery, National Heart and Lung Institute, Harefield Hospital.
authors.forename: D V
authors.initials: DV
authors.lastname: Cumming
authors.forename: A M
authors.initials: AM
authors.lastname: Seymour
authors.forename: C T
authors.initials: CT
authors.lastname: Bowles
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Kalsi
authors.forename: S S
authors.initials: SS
authors.lastname: Shah
authors.forename: R D
authors.initials: RD
authors.lastname: Pritchard
authors.forename: C W
authors.initials: CW
authors.lastname: Pattison
authors.forename: J R
authors.initials: JR
authors.lastname: Pepper
authors.forename: M H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D015908:Counterpulsation / Q000379:methods*; D004599:Electric Stimulation Therapy; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000502:physiology; D009132:Muscles / Q000378:metabolism* / Q000637:transplantation; D010101:Oxygen Consumption / Q000502:physiology; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D012756:Sheep; D013524:Surgical Flaps; D013997:Time Factors
chemical_list: D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate