ANCA with specificity for lactoferrin in systemic lupus erythematosus (SLE).
Antibodies to lactoferrin were detected in about 20% of patients with SLE, irrespective of the presence of renal involvement and in 10% of patients with rheumatoid arthritis and in 19% of patients with scleroderma. We conclude that anti-lactoferrin antibodies may be found in different types of connective tissue disease. Their clinical significance in these diseases however remains to be elucidated.
Sinico
R A
RA
Divisione di Nefrologia, Ospedale S. Carlo, Milano, Italy.
Pozzi
C
C
Radice
A
A
Tincani
A
A
D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D003240:Connective Tissue Diseases / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007781:Lactoferrin / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D007781:Lactoferrin