Paralysis and early death in cysteine string protein mutants of Drosophila.
Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.
Zinsmaier
K E
KE
California Institute of Technology, Division of Biology, Pasadena 91125.
Eberle
K K
KK
Buchner
E
E
Walter
N
N
Benzer
S
S
D000818:Animals; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000502:physiology*; D004596:Electroretinography; D017353:Gene Deletion; D017344:Genes, Insect; D005804:Genes, Lethal; D005816:Genetic Complementation Test; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D016297:Mutagenesis, Site-Directed; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology*; D017729:Presynaptic Terminals / Q000737:chemistry / Q000502:physiology*; D009435:Synaptic Transmission
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins