[Studies of the effect of cephradine and lincomycin on dynamics of selected parameters of nonspecific cellular immunity in experimental animals].
Rabbits of group I received cephradine i.m. and of group II lincomycin in mean therapeutic doses (calculated by body weight) for seven days. Determinations were performed before application of antibiotics and at 7, 14, 28 and 42 days of the study. Following tests were performed: phagocytosis index by determination of phagocytizing neutrophils, phagocytosis index and the NBT test. After application of cephradine, each determination revealed significant decrease of percentage of phagocytosing neutrophils, whereas phagocyte index was lowered at 14 day and the NBT value in 14 and 28 days of investigation. After application of lincomycin, value of percentage of phagocytosing neutrophils was lowered at the 14 day, and of phagocytosis index at the 7 day. NBT test values were lowered at 7 and 28 day and increased at the 42 day of the study.
Jasińska
B
B
Katedra i Zakład Mikrobiologii Lekarskiej AM w Lublinie.
Szeniawska
A
A
Hencner
Z
Z
Fota-Markowska
H
H
D000818:Animals; D002515:Cephradine / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects*; D008034:Lincomycin / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits
D008034:Lincomycin; D002515:Cephradine
Badania nad wpływem cefradyny oraz linkomycyny na dynamike wybranych parametrów odporności komórkowej nieswoistej zwierzat doświadczalnych.