New antiviral antibiotics, kistamicins A and B. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.
Naruse
N
N
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Tenmyo
O
O
Kobaru
S
S
Hatori
M
M
Tomita
K
K
Hamagishi
Y
Y
Oki
T
T
D000192:Actinomycetales / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D005285:Fermentation; D006367:HeLa Cells; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D001426:Bacterial Proteins; D010455:Peptides; C085613:kistamicin A; C085614:kistamicin B