[The importance of the HLA complex antigens in systemic rheumatoid diseases].
The submitted paper reviews contemporary knowledge on the clinical impact of assessment of HLA-complex antigens in systemic rheumatic diseases. The authors explain the term "relative risk" and its practical importance. As to antigens of the HLA-complex class I, attention was paid in particular to the importance of HLA B 27 in ankylosing spondylitis, other spondylarthropathies and reactive arthritis; in this part the review is supplemented by results of the authors' own research. As to antigens of the HLA-complex class II, attention was paid to the sub-area DR in rheumatoid arthritis and other diffuse affections of connective tissue. The advance in knowledge of the clinical impact of investigations of selected HLA-complex antigens in systemic rheumatic diseases is that in many instances it reveals an association not only at the level of the nosological unit but frequently also sub-unit with prognostically important clinical and biochemical manifestations, a typical autoantibody profile and sometimes also with the risk of a greater organ toxicity of drugs.
Hrncírová
L
L
II. interní katedra Lékarské fakulty Masarykovy univerzity a II. interní klinika FNsP, Brno.
Hrncír
Z
Z
D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D012216:Rheumatic Diseases / Q000276:immunology*
D006680:HLA Antigens
Antigen HLA-komplexu s vyznamem u systémových revmatických nemocí.