[Studies on uranium mobilization agents VI: synthesis of 2,3-dihydroxy-4-carbomethoxybenzyl aminocarboxylic acid amides chelating agents].
In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N-(substituted carbamoylmethyl)-2,3-dihydroxy-4-carbomethoxybenzylamine was synthesized starting with o-vanillin. The effect on detoxication of UO2(NO3)2, CuSO4 and NiCl2 in mice was tested. Some of them (IVa, IVd, IVf and IVg) were shown to be good antidotes for acute uranium intoxication, but all were less effective for Cu2+ and Ni2+.
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Shanghai Institute of Materia Medica, Academia Sinica.
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D000577:Amides / Q000138:chemical synthesis*; D000818:Animals; D001596:Benzylamines / Q000138:chemical synthesis*; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D051379:Mice; D011041:Poisoning / Q000188:drug therapy; D014501:Uranium / Q000506:poisoning
D000577:Amides; D001596:Benzylamines; D002614:Chelating Agents; D014501:Uranium