title: Conditioned nausea after cancer chemotherapy and autonomic nervous system conditionability.
abstract: There are marked individual differences in conditioned nausea after cancer chemotherapy. To examine if part of this variation is associated with individual differences in autonomic nervous system conditionability, the present study addressed whether patients with conditioned nausea acquired conditioned heart rate and electrodermal responses at a different rate than patients without conditioned nausea. Of 28 relapse-free patients who had completed cisplatinum treatment for testicular cancer between 1981 and 1986, 10 reported persistent conditioned nausea, 8 extinguished conditioned nausea and 10 no conditioned nausea. These three groups were subjected to a differential conditioning paradigm with 8 sec pictorial stimuli (circles and triangles) serving as conditioned stimuli for an unconditioned electric shock while heart rate and electrodermal activity was monitored. There were 4 habituation, 8 acquisition and 8 extinction trials with each of the two cues. Analyses of variance using nausea status as the independent variable and physiological responses as the dependent lended some support to the notion that conditioned heart rate deceleration developed in response to the reinforced compared to the nonreinforced cue during acquisition in the two groups with persistent or extinguished conditioned nausea but not in the group with no conditioned nausea. In addition, patients that displayed good, as compared to poor heart rate conditionability during acquisition, were more likely to have persistent conditioned nausea, whereas those who showed poor heart rate conditioning mostly were those without conditioned nausea. Electrodermal variables revealed no systematic differences between groups. This tentatively supports that individual differences in parasympathetic but not sympathetic nervous system conditionability may be associated with individual differences in conditioned nausea resulting from cancer chemotherapy.
authors.affiliation: Antimetic Research Unit, Radiumhemmet, Karolinska Institute, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Fredrikson
authors.forename: T
authors.initials: T
authors.lastname: Hursti
authors.forename: P
authors.initials: P
authors.lastname: Salmi
authors.forename: S
authors.initials: S
authors.lastname: Börjeson
authors.forename: C J
authors.initials: CJ
authors.lastname: Fürst
authors.forename: C
authors.initials: C
authors.lastname: Peterson
authors.forename: G
authors.initials: G
authors.lastname: Steineck
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001341:Autonomic Nervous System / Q000187:drug effects*; D002648:Child; D003214:Conditioning, Classical; D064420:Drug-Related Side Effects and Adverse Reactions; D005712:Galvanic Skin Response; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology*; D013736:Testicular Neoplasms / Q000188:drug therapy*