title: Molecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I.
abstract: In this article, we explore the hypothesis that tumor cells can escape recognition by CD8+ T cells via deficiencies in antigen processing and presentation. Aspects of the molecular and cellular biology of major histocompatibility complex class I are reviewed. Evidence for histology-specific molecular mechanisms in the antigen-processing and -presentation deficiencies observed in some human and murine tumors is presented. Mechanisms identified include down-regulation of antigen processing, loss of functional beta 2-microglobulin, and deletion of specific alpha-chain alleles. Finally, we discuss studies using an antigen-presentation-deficient mouse tumor as a model for the immunogenetherapy of an antigen-presentation deficiency.
authors.affiliation: Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: N P
authors.initials: NP
authors.lastname: Restifo
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
authors.forename: F
authors.initials: F
authors.lastname: Marincola
authors.forename: P
authors.initials: P
authors.lastname: Shamamian
authors.forename: A
authors.initials: A
authors.lastname: Taggarse
authors.forename: F
authors.initials: F
authors.lastname: Esquivel
authors.forename: S A
authors.initials: SA
authors.lastname: Rosenberg
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm; D003131:Combined Modality Therapy; D015316:Genetic Therapy; D015395:Histocompatibility Antigens Class I; D006801:Humans; D007167:Immunotherapy; D007371:Interferon-gamma / Q000235:genetics; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D015395:Histocompatibility Antigens Class I; D007371:Interferon-gamma