Model of mammalian cell reproductive death. I. Basic assumptions and general equations.
A systemic model describing the major radiobiological effects of various types of radiation is proposed. The model base lines were substantiated, and general mathematical equations for cell survival developed. The model takes into consideration such physical and biological factors as linear energy transfer, ion track structure, and structural and functional organization of interphase chromatin. This paper presents the basic assumptions made and general equations for the cell killing.
Obaturov
G M
GM
Medical Radiological Research Centre, Russian Medical Science Academy, Obninsk.
Moiseenko
V V
VV
Filimonov
A S
AS
D000818:Animals; D016923:Cell Death / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects; D004249:DNA Damage; D008433:Mathematics; D008954:Models, Biological; D011829:Radiation Dosage