title: Synthesis and biological activity of tricyclic, conformationally restricted analogs of lipophilic pyrido[2,3-d]-pyrimidine antifolates.
authors.affiliation: Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282.
authors.forename: A
authors.initials: A
authors.lastname: Gangjee
authors.forename: F
authors.initials: F
authors.lastname: Mavandadi
authors.forename: S F
authors.initials: SF
authors.lastname: Queener
mesh_terms: D000818:Animals; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008958:Models, Molecular; D008968:Molecular Conformation; D011010:Pneumocystis / Q000201:enzymology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D014122:Toxoplasma / Q000201:enzymology
chemical_list: D005493:Folic Acid Antagonists; D011743:Pyrimidines