[Clinical experience with the use of piroxicam in fast-dissolving sublingual capsules in acute recurrent osteoarthritis].
Open, non comparative study to evaluate the efficacy and safety of piroxicam Fast Dissolving Dosage Form (FDDF) for sublingual administration in treatment of reacutized osteoarthritis. Fifty-four patients with flare-ups of osteoarthritis involving various joints were enrolled in the study. They were treated with 20 mg/die piroxicam sublingual tablets for a total of 4 weeks. Drug efficacy was evaluated on the basis of the variation of spontaneous pain, pain on passive motion, functional limitation and capacity of performing a specific activity. Intensity of spontaneous pain on the first day showed a statistically significant improvement (p < 0.0001) only 15 minutes after the drug administration. This improvement in pain intensity increased until day 3. All other efficacy parameters showed a statistically significant improvement (p < 0.0001) 7 days after the beginning of treatment. Local and systemic tolerability was good. No patient showed local side effects; only 6 patients experienced systemic side effects. In conclusion, piroxicam sublingual tablets for treatment of osteoarthritis flare-ups showed analgesic efficacy already 15 minutes after drug administration, and good anti-inflammatory efficacy with good local and systemic tolerability.
Minisola
G
G
Divisione di Reumatologia, Ospedale S. Camillo di Roma.
Bancheri
C
C
Bogliolo
A
A
Brundisini
B
B
Gospodinoff
L
L
Lucentini
L
L
Porzio
F
F
Perpignano
G
G
D000208:Acute Disease; D000286:Administration, Sublingual; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D010146:Pain / Q000188:drug therapy; D010894:Piroxicam / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012008:Recurrence
D004304:Dosage Forms; D010894:Piroxicam
Esperienza clinica sull'impiego del piroxicam compresse sublinguali a rapida dissoluzione nell'osteoartrosi riacutizzata.