The effects of albumin administration on microvascular permeability at the site of burn injury.
In a canine hind leg model, lymph flow (QL), lymph (CL), and plasma (CP) total protein concentrations, the reflection coefficient for total proteins (sigma d), and the filtration coefficient (Kf) were determined before and for 6 hours after a 5-second 100 degrees C hind paw scald (3% total body surface area, TBSA). Before injury, hind leg venous pressure was elevated and maintained by outflow restriction until a minimal, steady-state CL/CP ratio was achieved. Albumin (5%) was infused 30 minutes after the scald at low (0.4 mL/kg/% TBSA) or high (2 mL/kg/% TBSA) doses. Scald uniformly increased QL, CL/CP, Kf, and paw weight gain (PWG). Whereas postburn infusion of low-dose albumin mildly attenuated increases in CL/CP and PWG noted in scald-alone animals, no differences were noted between the scald and scald/high-dose albumin groups.
Collins
J N
JN
University of South Alabama Department of Surgery, Mobile 36688.
Dyess
D L
DL
Ardell
J L
JL
Townsley
M I
MI
Taylor
A E
AE
Ferrara
J J
JJ
D000418:Albumins / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001830:Body Surface Area; D002056:Burns / Q000097:blood / Q000145:classification / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D002199:Capillary Permeability / Q000187:drug effects*; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics; D006614:Hindlimb / Q000098:blood supply / Q000293:injuries*; D007262:Infusions, Intravenous; D015601:Injury Severity Score; D008196:Lymph / Q000737:chemistry / Q000502:physiology; D009929:Organ Size; D012212:Rheology
D000418:Albumins; D001798:Blood Proteins