title: Mismatch negativity in hyperactive children: effects of methylphenidate.
abstract: This pilot study investigates electrophysiological correlates of methylphenidate (MP) treatment among hyperkinetic children who are clinical responders to therapy. Event-related potentials were obtained from a small sample (6 hyperactive and 5 controls) during an auditory "oddball" task. In the ignore condition, oddball tones elicited a frontocentral "mismatch" negativity (MMN) during the 100- to 200-msec latency range following stimulus presentation. In the attend condition, oddball target tones elicited a centroparietal P3 as well. MP significantly decreased hyperkinetic behaviors. Preliminary analyses of the electrophysiological data indicated a decreased amplitude of the P3 waveform among hyperkinetic children and a trend toward normalization on MP. Waveform abnormalities in the latency range of control MMN suggested either a decrease in MMN amplitude or an increase in MMN latency in hyperactive subjects along with a trend toward normalization by MP. The preliminary data are suggestive of information-processing abnormalities among hyperactive children that may be sensitive to MP therapy.
authors.affiliation: Brookdale Hospital Medical Center, Brooklyn, NY 11212.
authors.forename: B G
authors.initials: BG
authors.lastname: Winsberg
authors.forename: D C
authors.initials: DC
authors.lastname: Javitt
authors.forename: G S
authors.initials: GS
authors.lastname: Silipo
authors.forename: P
authors.initials: P
authors.lastname: Doneshka
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D006801:Humans; D008774:Methylphenidate / Q000627:therapeutic use*; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales
chemical_list: D008774:Methylphenidate