Prognostic significance of the CaMBr1 antigen on breast carcinoma: relevance of the type of recognised glycoconjugate.
An extensive study of the expression of the blood group-related antigen CaMBr1 has been performed by immunohistochemistry, immunoblotting and high performance thin layer chromatography both on frozen and paraffin-embedded (paraffin) samples from normal and neoplastic breast tissues. The glycolipid antigenic fraction (from frozen samples) was preferentially expressed on functioning breast epithelium. In a prospective series of 143 breast cancer cases CaMBr1 expression was associate, on frozen sections, with the transferrin receptor (P = 0.01), the positivity with oestrogen receptor immunochemical assay (P = 0.06), premenopausal status (P = 0.06) and node negativity (P = 0.07). Non-significant correlation with longer disease-free survival (DFS) was observed. In a retrospective series of 862 cases on paraffin sections the glycoproteic antigenic fraction was significantly associated with premenopausal status (P < 0.05) and lobular histotype (P < 0.01), but failed to predict survival, although a trend for longer DFS was observed for positive cases.
Perrone
F
F
Division of Experimental Oncology E, PRESTCO, Milan, Italy.
Ménard
S
S
Canevari
S
S
Calabrese
M
M
Boracchi
P
P
Bufalino
R
R
Testori
S
S
Baldini
M
M
Colnaghi
M I
MI
D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000401:mortality; D005260:Female; D006017:Glycolipids / Q000032:analysis*; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D015151:Immunoblotting; D009363:Neoplasm Proteins / Q000032:analysis; D017697:Premenopause; D011379:Prognosis; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000032:analysis; D011990:Receptors, Transferrin / Q000032:analysis; D012189:Retrospective Studies
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006017:Glycolipids; D006023:Glycoproteins; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D011990:Receptors, Transferrin