title: Cardiac effects of coronary arteriography with electrolyte addition to iohexol. A study in dogs with and without heart failure.
abstract: Electrolyte addition to nonionic contrast media has been suggested to further reduce the incidence of ventricular fibrillation during coronary arteriography. The present study was designed to investigate the effects of adding 30 mM NaCl, 0.9 mM KCl, 0.15 mM CaCl2 and 0.1 mM MgCl2 to iohexol on cardiac electrophysiology and hemodynamics (iohexol+electrolytes = IPE). Contrast media were injected into the left main coronary artery in 9 open-chest, anesthetized dogs before and after induction of acute ischemic heart failure. IPE increased left ventricular inotropy (LV dP/dtmax) with no initial decrease, even during heart failure. During heart failure IPE induced the same hemodynamic effects as iohexol without electrolyte addition. IPE slightly lengthened epicardial monophasic action potential duration before heart failure. We conclude that IPE appears to be well tolerated hemodynamically. The electrophysiologic differences between IPE and iohexol are small when the injection time is not longer than 5 s.
authors.affiliation: Department of Medical Physiology, University Hospital, Tromsø, Norway.
authors.forename: H K
authors.initials: HK
authors.lastname: Pedersen
authors.forename: E A
authors.initials: EA
authors.lastname: Jacobsen
authors.forename: H
authors.initials: H
authors.lastname: Refsum
authors.forename: N E
authors.initials: NE
authors.lastname: Kløw
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002122:Calcium Chloride / Q000008:administration & dosage; D002302:Cardiac Output / Q000187:drug effects; D002303:Cardiac Output, Low / Q000503:physiopathology*; D017023:Coronary Angiography / Q000379:methods; D003331:Coronary Vessels; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D004573:Electrolytes / Q000008:administration & dosage* / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007267:Injections; D007472:Iohexol / Q000008:administration & dosage* / Q000494:pharmacology; D015636:Magnesium Chloride / Q000008:administration & dosage; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000503:physiopathology; D011189:Potassium Chloride / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D016277:Ventricular Function, Left / Q000187:drug effects; D017725:Ventricular Pressure / Q000187:drug effects
chemical_list: D004573:Electrolytes; D015636:Magnesium Chloride; D007472:Iohexol; D012965:Sodium Chloride; D011189:Potassium Chloride; D002122:Calcium Chloride