title: Oral megadose methylprednisolone versus intravenous immunoglobulin for acute childhood idiopathic thrombocytopenic purpura.
abstract: Twenty children with acute idiopathic thrombocytopenic purpura (ITP) were randomized to receive either oral megadose methylprednisolone (MDMP) or intravenous immunoglobulin G (IV IgG). Normal platelet counts (> or = 150 x 10(9)/l) were obtained in 6 patients of each group in 3 days and in 8 and 9 patients treated with oral MDMP and with IV IgG within 1 week, respectively. It is concluded that oral MDMP could easily be used for the early elevation of platelet counts, which is important for ITP treatment.
authors.affiliation: Department of Pediatric Hematology, University of Hacettepe, Medical Faculty, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ozsoylu
authors.forename: T R
authors.initials: TR
authors.lastname: Sayli
authors.forename: G
authors.initials: G
authors.lastname: Oztürk
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous; D008775:Methylprednisolone