title: Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine.
abstract: Two new quinochalcone C-glycosides, hydroxysafflor yellow A (1a) and tinctormine (2a), were isolated from Carthamus tinctorius L. (Compositae) together with carthamin, safflor yellow B and safflomin C. The structures of 1a and 2a have been determined by spectroscopic methods including heteronuclear multiple-bond multiple-quantum coherence and linked scan FAB-MS. The latter compound (2a) was demonstrated to have potent Ca2+ antagonistic action.
authors.affiliation: Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
authors.forename: M R
authors.initials: MR
authors.lastname: Meselhy
authors.forename: S
authors.initials: S
authors.lastname: Kadota
authors.forename: Y
authors.initials: Y
authors.lastname: Momose
authors.forename: N
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: A
authors.initials: A
authors.lastname: Kusai
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Namba
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004285:Dogs; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D010860:Pigments, Biological; D011809:Quinones; C080189:tinctormine; C085278:hydroxysafflor yellow A; D002599:Chalcone