[The effects of synthetic protease inhibitor on motility of the human duodenal papilla].
We studied the effects of synthetic protease inhibitors on the motility of the human duodenal papilla. Before and after the intravenous administration of gabexate mesilate (GM) or nafamostat mesilate (NM), the duodenal papillary pressure was measured with a catheter tip pressure transducer under duodenoscopy. GM was administered to fourteen subjects at 1 and 3 mg/kg/h. The peak pressure and the basal pressure were dose-dependently reduced by GM, but the frequency did not change. The blood CCK concentration was not changed after GM administration. NM was administered to twelve subjects at 0.3 mg/kg/h. Both the papillary pressure and the frequency were not changed by NM. GM inhibited the papillary motility, but NM had no consistent effect on the papillary motility.
Okushima
K
K
Department of Internal Medicine, Fujita Health University School of Medicine, Second Teaching Hospital.
Nakazawa
S
S
Inui
K
K
Yoshino
J
J
Yamao
K
K
Yamachika
H
H
Kanemaki
N
N
Wakabayashi
T
T
Fujimoto
M
M
Hirano
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000187:drug effects* / Q000503:physiopathology; D001550:Benzamidines; D003864:Depression, Chemical; D005260:Female; D016670:Gabexate / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006146:Guanidines / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*
D001550:Benzamidines; D006146:Guanidines; D011480:Protease Inhibitors; D016670:Gabexate; C032855:nafamostat