Correction of a disturbance in visual recognition in monkeys with the aid of an antioxidant.
The influence of an effective antioxidant, oxymethacil, was studied in a model of the disruption of visual recognition induced by the antidepressant fluoracyzine. The normal discrimination of black and white visual stimuli in monkeys is restored with the systemic administration of oxymethacil in a dose of 3 mg/kg following disruption brought about by the effect of fluoracyzine. The discrimination of colored visual stimuli, as in the norm, is restored following the systemic administration of oxymethacil in a dose of 4 mg/kg. The results obtained attest to the corrective properties of oxymethacil.
Dudkin
K N
KN
Laboratory of the Regulation of the Functions of Brain Neurons, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.
Kruchinin
V K
VK
Chueva
I V
IV
D000818:Animals; D000928:Antidepressive Agents; D000975:Antioxidants / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D004192:Discrimination, Psychological / Q000187:drug effects; D000882:Haplorhini; D010640:Phenothiazines; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000928:Antidepressive Agents; D000975:Antioxidants; D010640:Phenothiazines; C001228:fluoracizine; D014498:Uracil; C003029:oxymethacil