Microinjections of the metabotropic glutamate receptor agonist, trans-(+/-)-1-amino-cyclopentane-1,3-dicarboxylate (trans-ACPD) into the amygdala increase the acoustic startle response of rats.
The present study examined the effect of intraamygdaloid application of the metabotropic glutamate receptor agonist trans-ACPD on the acoustic startle response. Trans-ACPD led to a disruption of between-session habituation which is normally seen after repeated testing after injections of the vehicle into the amygdala. More specifically, a statistically significant increase of the magnitude of the startle response was observed 4 h after injection of 30 nmol of trans-ACPD into the central amygdaloid nucleus. The present findings suggest a role for the metabotropic glutamate receptor in the amygdala in the enhancement of the acoustic startle response.
Koch
M
M
Universität Tübingen, Germany.
D000161:Acoustic Stimulation; D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D003515:Cycloleucine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology*; D013216:Reflex, Startle / Q000187:drug effects*; D013997:Time Factors
D009498:Neurotoxins; D017470:Receptors, Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane