Development of human mast cells from their progenitors.
Two types of human mast cells, which are morphologically similar to skin mast cells and lung mast cells, respectively, can be developed from pluripotent stem cells under different culture conditions. The major growth factor for mast-cell development is c-kit ligand, which induces mastocytosis in vivo. However, this cytokine is not sufficient for full maturation of the cells.
Ishizaka
T
T
La Jolla Institute for Allergy and Immunology, California 92037.
Mitsui
H
H
Yanagida
M
M
Miura
T
T
Dvorak
A M
AM
D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D007378:Interleukins / Q000502:physiology; D008407:Mast Cells / Q000166:cytology* / Q000648:ultrastructure; D013234:Stem Cells / Q000166:cytology*
D007378:Interleukins