Congenital heart block in one of the HLA identical twins.
A case of HLA identical twins with one affected by congenital heart block is reported. Both twins, as their mother, had more than 12-fold higher anti-Ro antibody titers compared to healthy controls, but no differences were observed between the affected and the healthy baby. It is possible that there is a third factor causing the manifestation of this disease.
Kaaja
R
R
Department of Obstetrics and Gynecology, University of Helsinki, Finland.
Julkunen
H
H
Ammälä
P
P
Kurki
P
P
Koskimies
S
S
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D004200:Diseases in Twins; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006327:Heart Block / Q000276:immunology*; D006330:Heart Defects, Congenital / Q000276:immunology*; D006801:Humans; D011247:Pregnancy
D000974:Antibodies, Antinuclear; D006680:HLA Antigens; C035356:SS-A antibodies; C035357:SS-B antibodies