Renal abnormalities in leprosy.
We have evaluated laboratory and clinical manifestations of renal disease in 96 patients with leprosy, looking for a sensitive and early marker for detection and possibly follow-up of nephropathy in these patients. Microscopic hematuria was observed in 21.9% of the cases (with dysmorphic erythrocytes in 71.4% of them). Abnormal microalbuminuria and urinary beta 2-microglobulin were found in 15.8 and 19.8% of the cases, respectively. We have observed a high frequency of hematuria, abnormal microalbuminuria and elevation of urinary beta 2-microglobulin in these patients still with normal serum creatinine.
Kirsztajn
G M
GM
Department of Medicine, Escola Paulista de Medicina, São Paulo, Brazil.
Nishida
S K
SK
Silva
M S
MS
Ajzen
H
H
Pereira
A B
AB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000209:etiology; D015415:Biomarkers / Q000652:urine; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology* / Q000652:urine; D007918:Leprosy / Q000097:blood / Q000150:complications* / Q000652:urine; D008297:Male; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000652:urine
D015415:Biomarkers; D001613:beta 2-Microglobulin; D003404:Creatinine