Developmental anomalies in monozygous twins resembling the human homologue of the mouse mutant disorganization.
Human monozygous (Mz) twins are described with a pattern of abnormalities similar to those reported in heterozygous expression of the mouse mutant disorganisation gene (Ds). These include anomalies of the skeletal, gastrointestinal, genito-urinary and central nervous system. Concordance in Mz twins is suggestive of a genetic aetiology and lends further credence to the putative existence of a human homologue for Ds.
Wainwright
H
H
Department of Anat Path, University of Cape Town Medical School, Observatory, South Africa.
Viljoen
D
D
D000015:Abnormalities, Multiple / Q000235:genetics*; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities; D002490:Central Nervous System / Q000002:abnormalities; D004065:Digestive System Abnormalities; D004677:Encephalocele / Q000235:genetics; D005260:Female; D006222:Hamartoma / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D009154:Mutation; D014430:Twins, Monozygotic / Q000235:genetics*; D014564:Urogenital Abnormalities