[Nephrotoxic action of cadmium].
Functional state of kidney in persons exposed to cadmium (Cd) is estimated mostly by determination of low molecular proteins in urine (beta 2MG, RBP) they are sensitive but not specific indicators of Cd exposure effects. The usefulness of a new indicator of renal functional disorders which is similar to metallothionein was studied. The test involved the determination of the urinary excretion of cadmium bound to low molecular specific protein. It was assessed in population exposed to cadmium in industry (high cadmium concentration) and in population limited to the conditions of residential area (low cadmium concentrations). It was found, that CdBP excretion in urine was higher in a group of persons exposed to cadmium with renal dysfunction (regardless of level of exposure). This was closely correlated with beta 2MG and levels in urine. People with renal dysfunction,-unexposed to cadmium have not excreted any CdBP in urine.
Wrońska-Nofer
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Zakładu Biochemii Instytutu Medycyny, Lodzi.
Hałatek
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002104:Cadmium / Q000009:adverse effects* / Q000652:urine*; D004781:Environmental Exposure; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced* / Q000652:urine; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D002104:Cadmium
Nefrotoksyczne działanie kadmu.