Effect of dietary sodium chloride on the development of renal glomerular and vascular lesions in hypertensive rats.
1. The hypothesis that high levels of NaCl in the diet aggravates hypertension-associated renal vascular lesions was examined in unilaterally nephrectomized deoxycorticosterone acetate treated (DOCA) and two kidney one clip (2K1C) hypertensive rats, as well as normotensive controls. 2. High NaCl diet significantly increased systolic blood pressure (SBP) in DOCA rats, but had little effect on SBP in normal control rats, and did not affect the rise of SBP in 2K1C rats. 3. High NaCl diet was associated with a higher percentage of glomerular lesions and renal arterial and arteriolar lesions in DOCA and 2K1C rats (P < 0.05). 4. Thus high NaCl intake exacerbated renal arterial and arteriolar and glomerular lesions in both DOCA and 2K1C hypertensive rats. In 2K1C rats this effect may be in part independent of blood pressure.
Liu
D T
DT
Department of Medicine, St George Hospital, University of New South Wales, Kogarah, Australia.
Birchall
I
I
Kincaid-Smith
P
P
Whitworth
J A
JA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003900:Desoxycorticosterone; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood; D006978:Hypertension, Renovascular / Q000139:chemically induced* / Q000209:etiology / Q000503:physiopathology; D007668:Kidney / Q000033:anatomy & histology / Q000098:blood supply; D007674:Kidney Diseases / Q000139:chemically induced*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012077:Renal Artery / Q000187:drug effects*; D012083:Renin / Q000097:blood; D012307:Risk Factors; D017673:Sodium Chloride, Dietary / Q000633:toxicity*; D014556:Urine; D014652:Vascular Diseases / Q000139:chemically induced*
D004573:Electrolytes; D017673:Sodium Chloride, Dietary; D003900:Desoxycorticosterone; D012083:Renin