title: Biochemical and haematological changes following prolonged halothane anaesthesia in horses.
abstract: Six healthy horses were anaesthetised with halothane (1.2 times the horse minimal alveolar concentration) in oxygen for more than 12 hours. Serum bilirubin, aspartate aminotransferase, alkaline phosphatase and L-iditol dehydrogenase values were significantly (P < 0.05) increased for up to nine days after anaesthesia. These changes suggest an anaesthesia related liver dysfunction. Creatine kinase increased to an average of more than 1400 IU litre-1 24 hours after anaesthesia and this change is indicative of muscle cell disruption. Renal-associated biochemical results, (that is serum creatinine and inorganic phosphate concentrations) were significantly increased transiently and are indicative of reduced renal function during and immediately after anaesthesia. Plasma concentrations of eicosanoids (6-keto-PGF1a, PGF2a, PGE and thromboxane) following anaesthesia were not different from preanaesthetic values. The magnitude of liver and muscle cell related increases in serum enzyme activities resulting from prolonged halothane anaesthesia was in excess of that previously reported for anaesthesia of shorter duration.
authors.affiliation: Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: E P
authors.initials: EP
authors.lastname: Steffey
authors.forename: S N
authors.initials: SN
authors.lastname: Giri
authors.forename: C I
authors.initials: CI
authors.lastname: Dunlop
authors.forename: L K
authors.initials: LK
authors.lastname: Cullen
authors.forename: D S
authors.initials: DS
authors.lastname: Hodgson
authors.forename: N
authors.initials: N
authors.lastname: Willits
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D001772:Blood Cell Count / Q000662:veterinary; D001774:Blood Chemical Analysis / Q000662:veterinary*; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D006221:Halothane; D006454:Hemoglobins / Q000032:analysis; D006736:Horses / Q000097:blood*; D007442:Intubation, Intratracheal / Q000662:veterinary; D008297:Male; D012016:Reference Values; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D006221:Halothane