Investigation of nimodipine pharmacokinetics in Chinese patients with acute subarachnoid haemorrhage.
Nimodipine pharmacokinetics was investigated in 12 Chinese patients with acute subarachnoid haemorrhage receiving an IV infusion of 1.6 or 2 mg/h (based on estimated body weight) for 10 days. Peripheral venous blood samples were collected for up to 4 days and plasma nimodipine was assayed by GC/ECD. The mean value was taken as the steady state concentration (Css) and Clearance (CL) (hourly dose/Css) was calculated. Eight survivors were given oral nimodipine (60 or 90 mg) every 6h (based on body weight), blood was sampled over 6 h and the plasma nimodipine level determined. The values for Css, CL and CL.kg-1 were 33.5 micrograms.l-1, 58 l.h-1 and 1.0 l.h-1 x kg-1 respectively; in survivors receiving the drug orally, bioavailability of the 30 mg tablet was 9%. In one very sick patient given crushed tablets by naso-gastric tube, the AUC was very low; in vitro studies indicated that adsorption of nimodipine by the tubing was unlikely to have been the cause. The pharmacokinetic findings in Chinese patients are comparable to previously reported values in Caucasians.
Kumana
C R
CR
Department of Medicine, University of Hong Kong.
Kou
M
M
Yu
Y L
YL
Fong
K Y
KY
Fung
C F
CF
Chang
C M
CM
Mück
W
W
Lauder
I J
IJ
D000208:Acute Disease; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001682:Biological Availability; D005260:Female; D006723:Hong Kong; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009553:Nimodipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013345:Subarachnoid Hemorrhage / Q000378:metabolism*
D009553:Nimodipine