Fast 19F-NMR imaging in vivo using FLASH-MRI.
The goal of this study was the development of a method that allows the acquisition of chemical shift selective 19F NMR images within a short measuring time. A train of small tip angle frequency selective pulses, each followed by a dephasing gradient of random strength, was used as a presaturation experiment for the suppression of the unwanted chemical shift components. Imaging was performed after presaturation using a SNAPSHOT-FLASH experiment. The acquisition time for a 64 x 128 image including the presaturation experiment amounted to only 470 ms. The sequence was applied in a 4.7 Tesla magnet to perform a longitudinal pharmacological study on the clearance of perfluoroocytlbromide (PFOB) in the liver and spleen of rats.
Nöth
U
U
Physikalisches Institut, Universität Würzburg, Germany.
Jäger
L J
LJ
Lutz
J
J
Haase
A
A
D000818:Animals; D005461:Fluorine; D005466:Fluorocarbons / Q000493:pharmacokinetics; D006842:Hydrocarbons, Brominated; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism
D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D005461:Fluorine; C003072:perflubron