[Leukocyte mobility in modulation of activity of the cell signalling system].
The mobility of the rat polymorphonuclear leukocytes (PMNL) has been studied. It was shown, that it is greatly determined by the balance of adenylate cyclase (AdC) and Ca-polyphosphoinositide (Ca-PPI) cell signalling systems. Various compounds whose action on the activity of the signalling systems was previously connected with the membrane receptors, proved to be capable to affect the activity of submembrane elements of these systems. It is concluded that multiple areas of bioregulators fixation within the limits of the signal cascades are available.
Luĭk
A I
AI
Mogilevich
S E
SE
Radchenko
I V
IV
Kondrashova
L N
LN
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000097:blood; D000262:Adenylyl Cyclases / Q000097:blood; D000595:Amino Acid Sequence; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000166:cytology / Q000502:physiology*; D018129:Phosphatidylinositol Phosphates / Q000097:blood; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*
D018129:Phosphatidylinositol Phosphates; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases
Izuchenie podvizhnosti leĭkotsitov v usloviiakh moduliatsii aktivnosti signal'nykh sistem kletki.