Carbamazepine (Tegretol)-induced thrombocytopenia.
A case of carbamazepine-induced thrombocytopenia is reported. The patient, a 38-year-old female, developed thrombocytopenia 10 days after receiving 400 mg carbamazepine daily. The presence of an anti-IgG carbamazepine-dependent platelet-reactive antibody was documented. Using flow cytometry, the drug-induced antibody was detected at a drug concentration as low as 10(-6) M.
Shechter
Y
Y
Hematology Institute, Ramabam Medical Center, Haifa, Israel.
Brenner
B
B
Klein
E
E
Tatarsky
I
I
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D002220:Carbamazepine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D002220:Carbamazepine