Effects of a novel melatonin analog on circadian rhythms of body temperature and activity in young, middle-aged, and old rats.
Circadian rhythms of body temperature and activity were recorded in young, middle-aged, and old rats. A new melatonin analog, S20242, was administered daily around the onset of darkness for a 2-week period. Compared to the young animals, there was a significant age-related reduction in the amplitude and stability of body temperature and activity in both the middle-aged and old rats. In these two groups there was an improvement of the circadian rhythm of body temperature as a result of daily application of the melatonin analog.
Koster-van Hoffen
G C
GC
Netherlands Institute for Brain Research, Amsterdam.
Mirmiran
M
M
Bos
N P
NP
Witting
W
W
Delagrange
P
P
Guardiola-Lemaitre
B
B
D000375:Aging / Q000502:physiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011914:Rats, Inbred BN
D008550:Melatonin