Liposome targeting to rat brain: effect of osmotic opening of the blood-brain barrier.
To determine whether sulfatide liposomes can cross the blood-brain barrier (BBB) with or without osmotic treatment by mannitol, we administered liposomes through the internal carotid artery in rats. Sulfatide liposomes could pass the BBB with osmotic treatment, but not without osmotic treatment. Therefore, we propose that the combination method of administration of the reticuloendothelial-system avoiding liposomes with osmotic treatment can be useful for treatment of various kinds of brain diseases.
Sakamoto
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Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan.
Ido
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D015060:1,2-Dipalmitoylphosphatidylcholine; D000818:Animals; D001345:Autoradiography; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002339:Carotid Arteries; D002784:Cholesterol / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004337:Drug Carriers; D007269:Injections, Intra-Arterial; D007700:Kinetics; D008081:Liposomes; D008297:Male; D010713:Phosphatidylcholines; D051381:Rats; D017207:Rats, Sprague-Dawley; D013433:Sulfoglycosphingolipids; D013997:Time Factors; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D013433:Sulfoglycosphingolipids; D015060:1,2-Dipalmitoylphosphatidylcholine; D002784:Cholesterol