Pooled human IGG (PHIG) inhibits the binding of anti-myeloperoxidase antibodies to myeloperoxidase.
This study demonstrates that pooled human immunoglobulin (PHIG) contains anti-idiotypes to anti-myeloperoxidase (MPO) antibodies and can inhibit the binding of anti-MPO to MPO. The variability seen in the inhibitory effect of different PHIG preparations in the same and also in different patient sera suggests heterogeneity in the idiotypic repertoire of anti-MPO antibodies.
Pall
A A
AA
Renal Research Laboratories, Queen Elizabeth Hospital, Birmingham.
Varagunam
M
M
Adu
D
D
Smith
N
N
Taylor
C M
CM
Michael
J
J
D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology*; D001323:Autoantibodies / Q000276:immunology*; D002846:Chromatography, Affinity; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000494:pharmacology*; D009195:Peroxidase / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D009195:Peroxidase