title: Characterization of responders and nonresponders to tiaprofenic acid and naproxen in the treatment of patients with osteoarthritis.
abstract: OBJECTIVE
  To characterize responders/nonresponders to 2 nonsteroidal antiinflammatory drugs by a combination of start variables in the treatment of patients with osteoarthritis (OA) of the hip(s)/knee(s).
  
  
  METHODS
  Two hundred eight patients participated in a 3-week randomized double blind parallel group trial.
  
  
  RESULTS
  The responder rate to tiaprofenic acid and naproxen was 52 and 59%, respectively. Correctly characterized by use of a combination of 6 baseline variables were 79% of the patients treated with tiaprofenic acid and 81% treated with naproxen.
  
  
  CONCLUSIONS
  Both active drugs were found effective compared with placebo in patients with OA, but with different characteristics.
authors.affiliation: Centre of Rheumatology, Haukeland Hospital, University of Bergen, Norway.
authors.forename: H M
authors.initials: HM
authors.lastname: Høyeraal
authors.forename: H
authors.initials: H
authors.lastname: Fagertun
authors.forename: T
authors.initials: T
authors.lastname: Ingemann-Hansen
authors.forename: H
authors.initials: H
authors.lastname: Ersmark
authors.forename: O
authors.initials: O
authors.lastname: Rönn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016002:Discriminant Analysis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy*; D011422:Propionates / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid; D009288:Naproxen