title: [Semi-invasive pulmonary aspergillosis. Apropos of a case].
abstract: A 43-year-old man was admitted to hospital for excavated pneumopathy of the upper part of the right lung, revealed by signs of respiratory infection evolving for a few weeks and involving a 10-kg weight loss. The radiological and clinical evolution and the demonstration of Aspergillus fumigatus allowed establishing a diagnosis of semi-invasive aspergillosis. The treatment, associating amphotericin B and 5-fluorocytosine, replaced by itraconazole 15 days later, soon produced clinical healing and radiological improvement. Since serology remained positive, surgery was performed to remove the residual lesions after a 7-month course of itraconazole. Within the scope of this case, the diagnostic criteria of this form of pulmonary aspergillosis are discussed, as well as the merits and limitations of itraconazole.
authors.affiliation: Service de Pneumologie, Hôpital Saint Philibert, Lomme.
authors.forename: P
authors.initials: P
authors.lastname: Mulliez
authors.forename: A
authors.initials: A
authors.lastname: Darras
authors.forename: R
authors.initials: R
authors.lastname: Reesaul
authors.forename: F
authors.initials: F
authors.lastname: Malaquin
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D011013:Pneumonectomy; D012699:Serology; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents
vernacular_title: L'aspergillose pulmonaire semi-invasive. A propos d'une observation.