title: A microsatellite-based multipoint index map of human chromosome 22.
abstract: Utilizing the CEPH (Centre d'Etude du Polymorphism Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map.
authors.affiliation: Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
authors.forename: K H
authors.initials: KH
authors.lastname: Buetow
authors.forename: D
authors.initials: D
authors.lastname: Duggan
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Ludwigsen
authors.forename: J
authors.initials: J
authors.lastname: Puck
authors.forename: J
authors.initials: J
authors.lastname: Porter
authors.forename: M
authors.initials: M
authors.lastname: Budarf
authors.forename: R
authors.initials: R
authors.lastname: Spielman
authors.forename: B S
authors.initials: BS
authors.lastname: Emanuel
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D003001:Cloning, Molecular; D004247:DNA; D004276:DNA, Satellite / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004276:DNA, Satellite; D004247:DNA