title: Paratesticular neuroblastoma with N-myc activation.
abstract: The authors describe a case of disseminated neuroblastoma discovered as a paratesticular tumor in a 7-month-old boy. The ectopic adrenal tissues adjacent to the paratesticular tumor and multiple lesions in the adrenal gland and skin suggested the possibility of multifocal primary tumors. Although infantile neuroblastoma diagnosed at less than 1 year of age generally responds well to treatment irrespective of distant metastases, metastases developed, and the boy died of disease within 7 months. All multiple lesions had amplification and overexpression of the N-myc protooncogene, which might explain the aggressive phenotype of this rare case.
authors.affiliation: Department of Pediatric Surgery, Chiba University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Ohnuma
authors.forename: M
authors.initials: M
authors.lastname: Tanabe
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Enomoto
authors.forename: H
authors.initials: H
authors.lastname: Horie
authors.forename: H
authors.initials: H
authors.lastname: Shirasawa
authors.forename: B
authors.initials: B
authors.lastname: Simizu
mesh_terms: D015152:Blotting, Northern; D015139:Blotting, Southern; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics*; D005834:Genital Neoplasms, Male / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000235:genetics* / Q000556:secondary