title: Spontaneous factor VIII inhibitor occurring in association with chronic graft-versus-host disease.
abstract: The development of spontaneously acquired Factor VIII inhibitors is rare and may lead to serious hemorrhagic sequelae. We report here the case of a patient who acquired a Factor VIII inhibitor two years after an allogeneic bone marrow transplant for CML. This occurred in association with a flare of chronic graft versus host disease (GVDH). He responded to corticosteroid therapy. A review of autoimmune phenomena associated with chronic GVDH and the treatment of Factor VIII inhibitors is discussed.
authors.affiliation: Norris Cotton Cancer Center, Lebanon, New Hampshire 03756.
authors.forename: C W
authors.initials: CW
authors.lastname: Seidler
authors.forename: L E
authors.initials: LE
authors.lastname: Mills
authors.forename: M E
authors.initials: ME
authors.lastname: Flowers
authors.forename: K M
authors.initials: KM
authors.lastname: Sullivan
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000209:etiology; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002908:Chronic Disease; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006086:Graft vs Host Disease / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male
chemical_list: D005169:Factor VIII