[Pharmacokinetics of ciprofloxacin in young healthy volunteers].
Pharmacokinetic studies on ciprofloxacin were carried out in 6 young healthy volunteers. Serum and urine levels of ciprofloxacin were measured by reversed-phase high performance liquid chromatography. The drug obeyed one-compartment model kinetics in serum. The mean peak serum concentration, time to peak concentration and the area under the curve were 4.17 +/- 1.05mg/L, 1.75 +/- 0.40h and 18.09 +/- 2.69mg/L.h respectively after oral administration of 500mg of ciprofloxacin tablet. The elimination half life was 2.34 +/- 0.81h and the apparent volume of distribution was 3.71 +/- 0.75L. The urinary rate of ciprofloxacin over 24h after dosing was 34.22 +/- 6.57%. These data indicate that ciprofloxacin is easily absorbed and its concentration reaches the peak level rapidly. There are high levels of drug both in serum and urine.
Liang
D
D
Qin
Y
Y
Xu
N
N
Zhang
H
H
Li
J
J
D000328:Adult; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D014018:Tissue Distribution
D002939:Ciprofloxacin