Necrolytic migratory erythema: a report of three cases.
Necrolytic migratory erythema (NME) is a cutaneous reaction pattern with specific histopathologic features that is typically associated with a functioning pancreatic islet cell neoplasm such as a glucagonoma. Three examples of NME, each associated with a different cause, are presented: glucagonoma, pancreatic insufficiency, and gluten-sensitive enteropathy. All three patients were successfully treated by surgical resection of the pancreatic tumor, total parenteral nutrition and pancreatic enzyme replacement, or a strict gluten-free diet, respectively. All remain free of skin disease more than 2 years later. Any patient with NME should be evaluated for glucagonoma and small bowel disease that may be associated with malabsorption and malnutrition.
Thorisdottir
K
K
Department of Dermatology, Cleveland Clinic Foundation.
Camisa
C
C
Tomecki
K J
KJ
Bergfeld
W F
WF
D000328:Adult; D018273:Carcinoma, Islet Cell / Q000150:complications / Q000473:pathology; D002446:Celiac Disease / Q000150:complications; D004890:Erythema / Q000150:complications / Q000473:pathology*; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009748:Nutrition Disorders / Q000150:complications; D010190:Pancreatic Neoplasms / Q000150:complications / Q000473:pathology; D012867:Skin / Q000473:pathology