Scintigraphic potentials of J001X acylated poly-galactoside for imaging inflammatory lesions in pigs.
Although several approaches already exist for the imaging of inflammatory foci, new specific strategies providing functional data on the lesions are required to determine the extent of the disease and also to assess anti-inflammatory treatment. In our study, we investigated the scintigraphic potential of 99mTc-J001X, an agent developed for the targeting of macrophages. Due to its well documented and progressive evolution of lesions, a model of radiation-induced inflammation in pigs was chosen. Our results demonstrated the ability of J001X to provide images of inflammatory foci with a high contrast. The contribution of some specific and non-specific parameters possibly involved in the scintigraphic behavior of J001X is discussed.
Perin
F
F
Laboratoire de Biophysique Cellulaire et RMN, INSERM U316, Faculté de Médecine, Tours, France.
Pittet
J C
JC
Hoffschir
D
D
Normier
G
G
Binz
H
H
Le Pape
A
A
D000107:Acetylation; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005355:Fibrosis; D005710:Gallium Radioisotopes; D006017:Glycolipids; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000473:pathology; D008264:Macrophages / Q000000981:diagnostic imaging; D008297:Male; D009132:Muscles / Q000473:pathology / Q000528:radiation effects; D009220:Myositis / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013552:Swine; D017556:Technetium Compounds
D005710:Gallium Radioisotopes; D006017:Glycolipids; C075069:J001X; D017556:Technetium Compounds