Computer assisted sperm motility analysis at the moment of induced pregnancy during gonadotropin treatment for hypogonadotropic hypogonadism.
Two azoospermic patients with isolated hypogonadotropic hypogonadism (IHH) no. 1,24-year-old, and no. 2,31-year-old), never treated before, were given gonadotropin therapy (GT), (FSH, 225 IU/week, and HCG, 4000 IU/week) and followed up monthly for sperm characteristics. After 6 (no. 1) and 9 (no. 2) months of treatment, immotile spermatozoa appeared in the semen. Two months later motile spermatozoa also appeared. A motile sperm concentration sufficiently high for computer motion analysis (CASA) was achieved 1 month later 9th and 12th month, respectively. At the 13th (no. 1) and 17th (no. 2) month of GT, CASA showed a small population of spermatozoa with a very good motility pattern. In the next ovulatory cycle the patients' partners became pregnant.
Lenzi
A
A
Laboratorio di Immunologia della Riproduzione e Seminologia, Università di Roma La Sapienza, Italy.
Lombardo
F
F
Gandini
L
L
Alfano
P
P
Dondero
F
F
D000328:Adult; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000503:physiopathology; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D011247:Pregnancy; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D016896:Treatment Outcome
D006062:Gonadotropins