title: Altered immune response to proteins fed after neonatal exposure of piglets to the antigen.
abstract: The weaning of piglets onto soya proteins at 3 weeks old normally results in an active response to the fed protein, as determined by the appearance of serum IgG antisoya antibody. This system thus allows the effects of manipulation on the response to a fed protein to be studied. In animals previously given 1 g of soya protein at birth, the magnitude of the antibody response to soya fed at 3 weeks was decreased, although similar amounts of the fed protein could be detected in serum. In addition, the relative affinity of the dominant interaction between antigen and antibody was reduced in these piglets by almost an order of magnitude. By comparison, the ability of piglets given soya at birth to respond to injected soya was not significantly reduced. These results indicate that the regulation of responses to fed and systemic antigens is largely separate. Very early oral exposure to antigen may affect the ability of neonatal animals to mount immune responses to, specifically, fed proteins while leaving the response to systemic antigen largely intact.
authors.affiliation: Department of Veterinary Medicine, University of Bristol, Langford, UK.
authors.forename: M
authors.initials: M
authors.lastname: Bailey
authors.forename: B G
authors.initials: BG
authors.lastname: Miller
authors.forename: E
authors.initials: E
authors.lastname: Telemo
authors.forename: C R
authors.initials: CR
authors.lastname: Stokes
authors.forename: F J
authors.initials: FJ
authors.lastname: Bourne
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000915:Antibody Affinity / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D004044:Dietary Proteins / Q000008:administration & dosage / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D014674:Plant Proteins, Dietary / Q000008:administration & dosage / Q000276:immunology*; D011863:Radioimmunoassay; D030262:Soybean Proteins; D013025:Glycine max; D013552:Swine
chemical_list: D000941:Antigens; D004044:Dietary Proteins; D007074:Immunoglobulin G; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins