Disruption of the immunopeptidergic network in dietary migraine.
This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.
Martelletti
P
P
Headache Centre, Rome University La Sapienza, Italy.
Stirparo
G
G
Rinaldi
C
C
Frati
L
L
Giacovazzo
M
M
D000328:Adult; D000704:Analysis of Variance; D016207:Cytokines / Q000097:blood*; D004032:Diet / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000209:etiology / Q000276:immunology*; D013997:Time Factors
D016207:Cytokines