The effect of antioxidant supplementation on a serum marker of free radical activity and abnormal serum biochemistry in alcoholic patients admitted for detoxification.
Alcoholics admitted for detoxification were entered into a double blind placebo controlled trial of oral supplementation with an antioxidant cocktail (vitamin E, beta carotene, vitamin C and selenium) in order to determine the effect of this supplementation on the rate of resolution of a serum marker of free radical activity and abnormal serum biochemistry. The molar proportion of linoleic acid that was diene conjugated (a marker of free radical activity), was increased in the alcoholics 2.9% +/- 1.2 (mean +/- S.D.) compared to normal controls 1.3% +/- 0.6 (P < 0.0001) but fell at a similar rate during the first week of hospitalisation in supplemented and placebo-treated patients with a mean fall of 53.7% (+/- 16.4 S.D.) in the placebo group and 56.0% (+/- 23.7) (P = 0.32, NS) in the antioxidant supplemented group. Similarly, there was no difference in the rate of fall between serum aspartate transaminase (AST) concentration in the two groups: the placebo group falling by a mean of 68.9% (+/- 35.2) and the antioxidant supplemented group falling by 70.1% (+/- 10.0) (P = 0.41, NS) over the first 7 days of hospitalization. Alcoholics had low serum concentrations of vitamin E compared with controls (15.6 mg/l +/- 6.2 S.D.) which rose more in the supplemented group over the period of a week (7.7 mg/l +/- 4.4 to 21.6 mg/l +/- 5.1) (a mean rise of 180.5%) compared with the placebo group (8.6 mg/l +/- 6.8 to 9.6 mg/l +/- 5.7)--a mean rise of 11.6% (P = 0.006).(ABSTRACT TRUNCATED AT 250 WORDS)
Butcher
G P
GP
Department of Medicine, Liverpool University, UK.
Rhodes
J M
JM
Walker
R
R
Krasner
N
N
Jackson
M J
MJ
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D001205:Ascorbic Acid / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D002338:Carotenoids / Q000008:administration & dosage; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005609:Free Radicals; D006403:Hematologic Tests; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000201:enzymology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000008:administration & dosage; D013375:Substance Withdrawal Syndrome / Q000097:blood* / Q000150:complications; D014810:Vitamin E / Q000008:administration & dosage; D019207:beta Carotene
D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D000431:Ethanol; D012643:Selenium; D001205:Ascorbic Acid