title: Ablation of luteal phase symptoms of Menière's disease with leuprolide.
abstract: Symptoms of Menière's disease in women may be exacerbated during the luteal phase of the menstrual cycle. This suggests a role for progesterone production and subsequent fluid redistribution as a predisposing factor for Menière's symptoms. We report the use of leuprolide acetate, a gonadotropin-releasing hormone agonist, in a woman with cyclic Menière's symptoms. This drug, which abolishes gonadotropin-dependent ovarian sex steroid production, alleviated the patient's symptoms during therapy. This observation offers further support to the hypothesis of sex hormone-related exacerbations of Menière's symptoms and provides a possible future treatment option for this debilitating disease.
authors.affiliation: Department of Obstetrics and Gynecology, Greenville Hospital System, SC.
authors.forename: T M
authors.initials: TM
authors.lastname: Price
authors.forename: T C
authors.initials: TC
authors.lastname: Allen
authors.forename: D L
authors.initials: DL
authors.lastname: Bowyer
authors.forename: T A
authors.initials: TA
authors.lastname: Watson
mesh_terms: D000328:Adult; D005260:Female; D012739:Gonadal Steroid Hormones / Q000037:antagonists & inhibitors; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology / Q000627:therapeutic use*; D008183:Luteal Phase / Q000187:drug effects / Q000502:physiology*; D008575:Meniere Disease / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D012739:Gonadal Steroid Hormones; D016729:Leuprolide