title: In-situ carcinoma adjacent to recurrent nasopharyngeal carcinoma. Evidence of a new growth?
abstract: Eighty biopsies from 74 patients with recurrent nasopharyngeal carcinoma diagnosed in the years 1988 to 1990 inculsive were reviewed. The overlying epithelium was assessed for the presence of in-situ malignant change using a Gomori reticulin stain in addition to the routine haematoxylin and eosin stain. In-situ change was seen in the overlying epithelium or adjacent epithelium in 11 of these biopsies from 10 patients (13.5%). These changes were extensive and where normal epithelium was seen there was an abrupt transition from the normal to abnormal epithelium. As patients treated for NPC sustain such a high risk of developing another new growth, close and careful follow up of these patients will allow a good opportunity for research into the carcinogenesis of this tumor.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital.
authors.forename: J
authors.initials: J
authors.lastname: Nicholls
authors.forename: J
authors.initials: J
authors.lastname: Sham
authors.forename: M H
authors.initials: MH
authors.lastname: Ng
authors.forename: D
authors.initials: D
authors.lastname: Choy
mesh_terms: D002278:Carcinoma in Situ / Q000473:pathology*; D006801:Humans; D009297:Nasal Mucosa / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012189:Retrospective Studies