Hydroxyzine in the treatment of interstitial cystitis.
Hydroxyzine is a piperazine, tricyclic, H1-receptor antagonist with unique properties, especially the inhibition of mast cell and neuronal secretion. Preliminary results indicate is has an unusual ability to reduce interstitial cystitis symptoms. The long history, lack of major side effects, wide availability, low cost, and apparent effectiveness of hydroxyzine compel presentation of these preliminary results.
Theoharides
T C
TC
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts.
D000284:Administration, Oral; D003556:Cystitis / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D006919:Hydroxyzine