title: Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies.
abstract: Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudo-obstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.
authors.affiliation: Servicio Anatomía Patológica, Hospital Príncipes de España, Hospitalet de Llobregat, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Condom
authors.forename: A
authors.initials: A
authors.lastname: Vidal
authors.forename: R
authors.initials: R
authors.lastname: Rota
authors.forename: F
authors.initials: F
authors.lastname: Graus
authors.forename: J
authors.initials: J
authors.lastname: Dalmau
authors.forename: I
authors.initials: I
authors.lastname: Ferrer
mesh_terms: D000912:Antibodies, Neoplasm / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000276:immunology / Q000473:pathology*
chemical_list: D000912:Antibodies, Neoplasm