[Anticholinesterase activity of certain carboranyl-containing thio- and selenoesters of pentavalent phosphorus acids].
Anticholinesterase activity of carboranyl containing thio- and selenoesters of pentavalent phosphorus acids has been studied. Insertion of the carboranyl substituents in the thioester group of phosphororganic compounds was found to increase the anticholinesterase activity as compared with the thioalkyl analogues. The compounds with B-carboranyl group are less active inhibitors of cholinesterase than their isomers with C-carboranyl group.
Balema
V P
VP
Rys
E G
EG
Sochilina
E E
EE
Iagodina
O V
OV
Moralev
S N
SN
Zhukovskiĭ
Iu G
IuG
Godovikov
N N
NN
Kabachnik
M I
MI
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D002091:Butyrylcholinesterase / Q000097:blood; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004952:Esters; D006736:Horses; D006801:Humans; D010757:Phosphorous Acids / Q000737:chemistry / Q000494:pharmacology*; D012643:Selenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D002800:Cholinesterase Inhibitors; D004952:Esters; D010757:Phosphorous Acids; D013438:Sulfhydryl Compounds; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D012643:Selenium
Antikholinésteraznaia aktivnost' nekotorykh karboranilsoderzhashchikh tio- i selenoéfirov kislot piativalentnogo fosfora.