In situ remineralization of enamel lesions using continuous versus intermittent fluoride application.
Remineralization of early enamel lesions was studied in situ using a F chewing gum or a F-releasing device (FRD). Enamel specimens with subsurface lesions were mounted in removable lower appliances in 6 adults. A F-free dentifrice was used for all regimens. Test groups chewed five sticks/day (0.1 mg F/stick), or one FRD (0.5 mg F/day) was mounted in the midline of the appliance. The microhardness was measured after the 21-day intraoral exposure, and in vitro acid resistance testing was performed. Separate specimens were used to measure F content or changes in mineral density. Comparable values for both F gum and FRDs were higher (p > 0.05) than controls for acid resistance testing and percent remineralization. The F content for FRDs exceeded that of both F gum and controls.
Wang
C W
CW
School of Dentistry, University of Michigan, Ann Arbor 48109-1078.
Corpron
R E
RE
Lamb
W J
WJ
Strachan
D S
DS
Kowalski
C J
CJ
D000328:Adult; D000704:Analysis of Variance; D002638:Chewing Gum; D004245:DMF Index; D003692:Delayed-Action Preparations; D003743:Dental Enamel / Q000378:metabolism*; D005260:Female; D005460:Fluorides, Topical / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017001:Tooth Demineralization / Q000378:metabolism*; D014089:Tooth Remineralization / Q000379:methods*
D002638:Chewing Gum; D003692:Delayed-Action Preparations; D005460:Fluorides, Topical