Serum beta-2-microglobulin level and residual renal function in peritoneal dialysis.
In 32 noncirrhotic patients on peritoneal dialysis, mean serum beta 2-microglobulin (s beta 2M) was 26.58 +/- 12.32 mg/l (9.7-63.5). We found a significant correlation between s beta 2M and serum creatinine (sCr; r = 0.760), blood urea nitrogen (BUN; r = 0.573), total creatinine and BUN clearance (r = 0.623 and 0.599, respectively), 24-hour Kt/V (r = 0.638), glomerular filtration rate (r = 0.623), 24-hour urine output (r = 0.669), serum total protein (r = 0.584) (p < 0.01 for all the above r values); beta 2M peritoneal clearance and mass transfer (r = 0.414 and 0.427, respectively; p < 0.05). Our data demonstrate and confirm the contribution of residual renal function in determining s beta 2M levels and it is seemingly more important than beta 2M peritoneal clearance.
Amici
G
G
Nephrology and Dialysis Division, Treviso Hospital, Italy.
Virga
G
G
Da Rin
G
G
Grandesso
S
S
Vianello
A
A
Gatti
P
P
Bocci
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001798:Blood Proteins; D001613:beta 2-Microglobulin; D003404:Creatinine