Experimental mycoses in congenitally immunodeficient rodents.
Congenitally immunodeficient rodents are playing a major role in clarifying host defense mechanisms and elucidating the virulence factors of a variety of mycotic agents. These murine models are also being used to study the histopathology and chemotherapy of a variety of fungal infections. Recent development of immunodeficient transgenic mice will make these murine models even more valuable for studies on the diagnosis, pathogenesis, immunity, and chemotherapy of fungal infections.
Balish
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Department of Surgery, University of Wisconsin Medical School, Madison 53706-1532.
D000818:Animals; D002177:Candidiasis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004198:Disease Susceptibility / Q000276:immunology; D005856:Germ-Free Life; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000235:genetics / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D008819:Mice, Nude / Q000382:microbiology; D016513:Mice, SCID / Q000382:microbiology; D008822:Mice, Transgenic; D009181:Mycoses / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D051381:Rats; D011923:Rats, Nude / Q000382:microbiology; D014774:Virulence