[Alcohol-related high blood pressure, and erythrocyte Na+/K(+)-ATPase activity, sodium and potassium concentrations].
Erythrocyte Na+/K(+)-ATPase activity (Ery-ATPase) and intra-erythrocyte sodium and potassium concentrations (Ery-Na, Ery-K) were determined in 83 men aged between 36 and 60 years. Volumes of alcohol consumed during the preceding one week (Alc) correlated significantly with blood pressure (BP), but not correlated with Ery-ATPase and Ery-K. Ery-Na showed a week inverse correlation with Alc, but the partial correlation after adjusting Ery-ATPase was not significant. Therefore, elevations of BP found in alcohol consumers are not related to changes in the cell-membrane Na+/K(+)-ATPase activity and intracellular Na and K concentrations. Ery-ATPase showed a borderline significant positive correlation with diastolic BP (0.05 < or = p < 0.10), independently of age, body mass index and Alc. The significance of the weak association in the pathogenesis of hypertension remains unclear.
Tsuritani
I
I
Department of Hygiene, Kanazawa Medical University, Ishikawa-pref.
Teraoka
K
K
Miyagoshi
M
M
Honda
R
R
Ishizaki
M
M
Yamada
Y
Y
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium