title: New antiviral antibiotics, kistamicins A and B. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
abstract: A new strain of Microtetraspora parvosata subsp. kistnae subsp. nov. (ATCC 55076) was found to produce new antiviral antibiotics, designated kistamicins A and B. These antibiotics exhibited activity against influenza virus type A and moderate activity against Gram-positive bacteria.
authors.affiliation: Bristol-Myers Squibb Research Institute, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Naruse
authors.forename: O
authors.initials: O
authors.lastname: Tenmyo
authors.forename: S
authors.initials: S
authors.lastname: Kobaru
authors.forename: M
authors.initials: M
authors.lastname: Hatori
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: Y
authors.initials: Y
authors.lastname: Hamagishi
authors.forename: T
authors.initials: T
authors.lastname: Oki
mesh_terms: D000192:Actinomycetales / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D005285:Fermentation; D006367:HeLa Cells; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D001426:Bacterial Proteins; D010455:Peptides; C085613:kistamicin A; C085614:kistamicin B