title: [Synthesis and antigenic activity of peptides from the C-terminal part of the NS4-protein of the hepatitis A virus].
abstract: A set of four peptides from the HCV NS4-protein C-terminal region (aa 1921-1940) were obtained by solid-phase synthesis using activated esters and symmetrical anhydrides of Boc-amino acids. Peptide 1921-1940 has demonstrated a positive reaction in ELISA with individual anti-HCV-positive sera from patients with acute and chronic hepatitis C (80% and 56%, respectively). We analysed the antigenic properties of the peptide 1921-1940 and its fragments and suggested at least two antibody recognizing sites to be contained in this region.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Semiletov
authors.forename: T V
authors.initials: TV
authors.lastname: Firsova
authors.forename: S N
authors.initials: SN
authors.lastname: Kuzin
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Khudiakov
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
mesh_terms: D000956:Antigens, Viral / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D016174:Hepacivirus / Q000737:chemistry*; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000737:chemistry*
chemical_list: D000956:Antigens, Viral; D010446:Peptide Fragments; D017361:Viral Nonstructural Proteins
vernacular_title: Sintez i antigennaia aktivnost' peptidov iz C-kontsevoĭ chasti nestrukturnogo NS4-belka virusa gepatita C.