Inhibition of proteinase 3 activity by peptides derived from human epidermis.
Elafin and antileukoprotease are potent peptide-like inhibitors of human leukocyte elastase and have been isolated from human skin and bronchial mucus. Elafin proved to be a potent inhibitor of proteinase 3, whereas other inhibitors of human leukocyte elastase such as antileukoprotease and eglin C proved to be much less effective.
Wiedow
O
O
Department of Dermatology, University of Kiel, Germany.
Lüdemann
J
J
Utecht
B
B
Christophers
E
E
D000595:Amino Acid Sequence; D004817:Epidermis / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D053146:Myeloblastin; D011480:Protease Inhibitors / Q000494:pharmacology*; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D011994:Recombinant Proteins / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D015843:Serpins / Q000494:pharmacology
D011480:Protease Inhibitors; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C028656:eglin proteinase inhibitors; D012697:Serine Endopeptidases; D053146:Myeloblastin