title: [Postoperative morbidity among alcohol abusers].
abstract: Retrospective studies suggest increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk associated with alcohol intake among patients undergoing surgery. We investigated 15 persons who required colorectal surgery and who were drinking at least five Danish drinks per day. These patients were matched for sex, nutrition, age, weight, cardio-pulmonary disease, diagnosis anesthesia, and surgery to 15 control persons who were consuming no more than two drinks daily. None of the patients showed signs of liver disease. The alcohol group developed more postoperative complications than controls (67 vs 20%, p < 0.05) and hospital stay was prolonged (20 vs 12 days, p < 0.05). Preoperatively, alcohol misusers had reduced left ventricular ejection fraction (54 vs 68%, p < 0.01). Delayed-type hypersensitivity responses were reduced in the alcohol group before (53 mm2 vs 78, p < 0.05) and after (18 mm2 vs 55, p < 0.01) surgery. Alcohol misusers had significantly longer bleeding times. Surgical stress responses, as assessed by changes in plasma cortisol and catecholamines, were higher among alcohol misusers (p < 0.05). Postoperative morbidity was increased in alcohol misusers without signs of liver damage. The mechanisms may include subclinical cardiac insufficiency, immunosuppression, and decreased haemostatic function. Preoperative alcohol consumption may be a more important risk factor for postoperative morbidity than previously thought.
authors.affiliation: Kirurgisk gastroenterologisk afdeling, Hvidovre Hospital, København.
authors.forename: H
authors.initials: H
authors.lastname: Tønnesen
authors.forename: K R
authors.initials: KR
authors.lastname: Petersen
authors.forename: L
authors.initials: L
authors.lastname: Højgaard
authors.forename: K H
authors.initials: KH
authors.lastname: Stokholm
authors.forename: H J
authors.initials: HJ
authors.lastname: Nielsen
authors.forename: U P
authors.initials: UP
authors.lastname: Knigge
authors.forename: H
authors.initials: H
authors.lastname: Kehlet
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D003108:Colonic Diseases / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D011446:Prospective Studies; D012002:Rectal Diseases / Q000601:surgery; D012307:Risk Factors
vernacular_title: Postoperativ morbiditet blandt alkoholmisbrugere.