Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).
Bavetsias
V
V
Institute of Cancer Research, Sutton, Surrey, U.K.
Jackman
A L
AL
Thornton
T J
TJ
Pawelczak
K
K
Boyle
F T
FT
Bisset
G M
GM
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D007939:Leukemia L1210; D051379:Mice; D015394:Molecular Structure; D010455:Peptides; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
D005493:Folic Acid Antagonists; D010455:Peptides; D011799:Quinazolines; D005492:Folic Acid; D013940:Thymidylate Synthase; C059966:ICI 198583