title: Effect of gamma-irradiated carbohydrates on isolated synaptic membranes.
abstract: The effect of gamma-irradiated solutions of carbohydrates, mainly glucose, upon Na+, K(+)-ATPase and lipid peroxidation in rat brain synaptosomal membranes was studied. The membrane damage by irradiated glucose was enhanced in the presence of Fe2+ and was diminished when a free-radical scavenger (BHT) or metal chelators (EDTA, EGTA) were present. It is suggested that a key element in the free-radical membrane damage by irradiated carbohydrates is an Fe(2+)-complex of some species of the radiolysis products. Participation of radiotoxins of carbohydrate origin in radiobiological effects is discussed.
authors.affiliation: Institute of Photobiology, Academy of Sciences of Belarus, Minsk.
authors.forename: G V
authors.initials: GV
authors.lastname: Kaler
authors.forename: T I
authors.initials: TI
authors.lastname: Lyskova
authors.forename: O I
authors.initials: OI
authors.lastname: Shadyro
authors.forename: S G
authors.initials: SG
authors.lastname: Samoilenko
authors.forename: I P
authors.initials: IP
authors.lastname: Edimecheva
authors.forename: S L
authors.initials: SL
authors.lastname: Aksentsev
authors.forename: S V
authors.initials: SV
authors.lastname: Konev
mesh_terms: D000818:Animals; D004492:Edetic Acid / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D005609:Free Radicals; D005720:Gamma Rays; D005947:Glucose / Q000528:radiation effects*; D006861:Hydrogen Peroxide / Q000633:toxicity; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000528:radiation effects; D013570:Synaptic Membranes / Q000528:radiation effects*
chemical_list: D005609:Free Radicals; D004533:Egtazic Acid; D004492:Edetic Acid; D006861:Hydrogen Peroxide; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose