title: [The MR tomography of focal liver lesions with the superparamagnetic contrast agent AMI-25 at 1.5 tesla].
abstract: Superparamagnetic iron oxide particles (AMI-25) were evaluated as a liver contrast agent in high-field MR imaging (1.5 T). 16 patients with up to 5 presumed focal liver lesions (liver metastases n = 8, HCC n = 5, Klatskin tumours n = 2, FNH n = 1) received 15 mumol Fe/kg BW intravenously and were examined via standard T1- and T2-weighted spin-echo sequences. Quantitative image analysis showed a post-contrast increase of the contrast-to-noise ratio (C/N) from 1.6 to 7.4 on SE 2,500/15 images (p < .05). However, C/N was in the same range on plain SE 2,500/90 scans. Blind evaluation by two independent readers revealed that AMI-25-enhanced images did not provide a significantly increased number of lesions. Two patients reported minor, self-limited side-effects (flush, back pain). We conclude that in contrast to reports at mid-field MR imagers, the use of AMI-25 at 1.5 T does not significantly improve the detection of focal liver lesions on conventional SE images.
authors.affiliation: Abteilung für Radiologische Diagnostik, Eberhard-Karls-Universität, Tübingen.
authors.forename: S H
authors.initials: SH
authors.lastname: Duda
authors.forename: M
authors.initials: M
authors.lastname: Laniado
authors.forename: A F
authors.initials: AF
authors.lastname: Kopp
authors.forename: E
authors.initials: E
authors.lastname: Grönewäller
authors.forename: K P
authors.initials: KP
authors.lastname: Aicher
authors.forename: P
authors.initials: P
authors.lastname: Pavone
authors.forename: E
authors.initials: E
authors.lastname: Jehle
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007501:Iron / Q000009:adverse effects; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis* / Q000453:epidemiology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000009:adverse effects; D011446:Prospective Studies; D013535:Suspensions
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D013535:Suspensions; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide
vernacular_title: MR-Tomographie fokaler Leberläsionen mit dem superparamagnetischen Kontrastmittel AMI-25 bei 1,5 Tesla.