Suramin selectively inhibits the non-adrenergic non-cholinergic inhibitory junction potential in the guinea-pig stomach.
In smooth muscle cells of the guinea-pig stomach fundus, transmural nerve stimulation evoked a cholinergic excitatory junction potential (e.j.p.) and, in the presence of atropine, a non-adrenergic non-cholinergic (NANC) inhibitory junction potential (i.j.p.). Suramin (> 10(-5) M), a putative inhibitor of the P2 purinoceptor, enhanced the e.j.p. amplitude and inhibited the i.j.p., with no significant effect on the membrane potential. Thus, a possible involvement of ATP in the generation of the NANC i.j.p. has to be considered.
Ohno
N
N
Department of Physiology, Nagoya City University Medical School, Japan.
Ito
K M
KM
Yamamoto
Y
Y
Suzuki
H
H
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D005748:Gastric Fundus / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects*; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism; D013498:Suramin / Q000494:pharmacology*
D011983:Receptors, Purinergic; D013498:Suramin