Oncogenes, tumor suppressors and viruses in oral squamous carcinoma.
The pathogenesis of oral squamous cell carcinoma involves recognised carcinogens in tobacco and/or alcohol but other factors, including viruses, may also have a role. This paper reviews the gene changes revealed in oral carcinoma, the evidence implicating viruses, and mechanisms whereby viruses may affect gene function.
Scully
C
C
University Department of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, England.
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000382:microbiology*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics* / Q000382:microbiology*; D009857:Oncogenes / Q000235:genetics*; D009858:Oncogenic Viruses / Q000235:genetics / Q000502:physiology*