Synergistic effects of carboxymethylcellulose and low molecular weight heparin in reducing adhesion formation in the rat uterine horn model.
OBJECTIVE
To investigate the effect of sodium carboxymethylcellulose (SCMC) and the combination of low molecular weight heparin (LMWH) with SCMC in the prevention of intraperitoneal adhesion.


METHODS
Thirty-eight rats underwent bilateral surgical injury to the uterine horn and the parietal peritoneum. In 13 rats, a solution of SCMC was instilled at laparotomy. In 11 rats, LMWH was delivered on to serosal and peritoneal defects, and SCMC was instilled. As a control group 14 rats were included in the study.


METHODS
Surgical Research Laboratory, Erciyes University.


METHODS
Female Wistar-Albino rats, weighing 200 to 250 g each.


METHODS
Adhesions between the uterine horn and the abdominal sidewall were scored for extent and severity two weeks after the initial surgery.


RESULTS
Although the mean adhesion score both in the SCMC group (2.8, s.d. 1.15) and in the SCMC with LMWH group (1.6, s.d 1.18) was found to be significantly lower than in the control group (3.4, s.d. 0.89) (p < 0.05 and p < 0.001, respectively), more favorable adhesion prophylaxis was achieved in the SCMC with LMWH group in comparison with the SCMC treatment group without any hemorrhagic complications (p < 0.001).


CONCLUSIONS
We conclude that SCMC with LMWH are highly effective in reducing postoperative adhesions in this animal model. SCMC with LMWH appears promising in adhesion prophylaxis.
Sahin
Y
Y
Department of Obstetrics and Gynecology, Erciyes University School of Medicine, Kayseri, Turkey.
Saglam
A
A
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D004195:Disease Models, Animal; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control* / Q000601:surgery; D014591:Uterine Diseases / Q000517:prevention & control* / Q000601:surgery; D014599:Uterus / Q000187:drug effects / Q000601:surgery*
D006495:Heparin, Low-Molecular-Weight; D002266:Carboxymethylcellulose Sodium