[Comparative study of the effect of cycloartane and cardiac glycosides on various parameters of myocardial metabolism in animals].
Administration of cycloartane (askendoside D-10 mg/kg, cyclosiversioside F-25 mg/kg) and heart glycosides (strophanthin K-0.36 mg/kg, celanide-1 mg/kg) for 3-10 days is found to exert unidirectional effect on the indices of carbon, lipid and adenine nucleotide metabolism in animal myocardium under study. Glycogen and ATP content increases under parallel decrease of lactate and nonesterified fatty acid content. Differences in the effect of cycloorthane and heart glycosides and especially on the indices of myocardial carbon metabolism were registered under more prolonged administration. Administration of heart glycosides in contrast to cycloorthane ones promotes a decrease of glycogen level and redox potential and increase of lactate content.
Khushbaktova
Z A
ZA
Syrov
V N
VN
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007799:Lanatosides / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D012503:Saponins / Q000494:pharmacology*; D013328:Strophanthins / Q000494:pharmacology; D014315:Triterpenes
D002301:Cardiac Glycosides; D005230:Fatty Acids, Nonesterified; D005960:Glucosides; D007773:Lactates; D007799:Lanatosides; D012503:Saponins; D013328:Strophanthins; D014315:Triterpenes; D019344:Lactic Acid; C052064:astragaloside A; C085352:cycloartane; C018548:lanatoside C; D000255:Adenosine Triphosphate; D006003:Glycogen; C029082:strophanthin K
Sravnitel'noe izuchenie vliianiia tsikloartanovykh i serdechnykh glikozidov na nekotorye pokazateli metabolizma miokarda u zhivotnykh.