Netilmicin kinetics in urology.
Plasma kinetics of netilmicin, an aminoglycoside antibiotic was studied in 62 patients undergoing urologic surgery. Despite the use of a standard 100 mg-dose, no toxic levels were achieved except in one patient. A poor correlation was found between netilmicin plasma elimination constant and creatinine clearance (r = 0.34, p = NS). We can conclude that the prediction of netilmicin plasma concentrations is not possible using only demographic patient's data. The monitoring of netilmicin levels should be performed in long-term treatments but not in 4-dose regimes such as in urologic prophylaxis.
Astobieta
A
A
Galdakao Hospital, Urology Service, Spain.
Calvo
R
R
Aguirre
C
C
Rodríguez-Sasiain
J M
JM
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014566:Urogenital System / Q000378:metabolism* / Q000601:surgery*
D009428:Netilmicin; D003404:Creatinine