[Synthesis of imidazo[1,2-a]pyridine derivatives and their reactions].
By the reaction of 2-benzoylmethylimidazoles (1a, b) with polarized olefins (2, 3) in the presence of K2CO3, the corresponding imidazo[1,2-a]pyridine derivatives (4, 5) were obtained. Methylsulfinylimidazopyridine derivative (7) obtained by the reaction of 5b with m-chloroperbenzoic acid (m-CPBA), easily underwent nucleophilic substitution to give the corresponding substituted compounds (8a--e). The substitution of chloroimidazopyridine derivative (11) with nucleophiles produced the corresponding substituted compounds (12a--d).
Ide
S
S
School of Pharmaceutical Sciences, Nagasaki University, Japan.
Katou
K
K
Itou
T
T
Motokawa
C
C
Chiyomaru
Y
Y
Matsuda
Y
Y
D000475:Alkenes; D002254:Carbonates; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011188:Potassium; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D002254:Carbonates; D007093:Imidazoles; D011725:Pyridines; C037593:potassium carbonate; D011188:Potassium