title: [The use of sodium gamma-oxybutyrate and gutimine for decreasing metabolic disorders in the heart, caused by exotoxic shock in acetic acid poisoning].
abstract: Exotoxic shock was simulated in non-linear rat males anesthetized with barbital after intragastric administration of 70% acetic acid at a dose of 4 ml/kg using a gastric tube. Energy metabolism and the rate of lipid peroxidation were studied in heart muscle during the decompensated and terminal periods of exotoxic shock. Sodium hydroxybutyrate (200 mg/kg) and gutimine (75 mg/kg), administered alone within 30 min after the poisoning, prolonged the period before manifestation of the decompensated and terminal steps of the shock; these drugs decreased the rate of metabolic impairments in the myocardium by decreasing the rates of adenine nucleotide catabolism, of glycolysis, lipolysis and lipid peroxidation.
authors.forename: I N
authors.initials: IN
authors.lastname: Petrin
authors.forename: V T
authors.initials: VT
authors.lastname: Dolgikh
authors.forename: I P
authors.initials: IP
authors.lastname: Krolevets
mesh_terms: D000085:Acetates / Q000506:poisoning*; D019342:Acetic Acid; D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D006019:Glycolysis; D006164:Guanylthiourea / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000037:antagonists & inhibitors; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D012772:Shock, Septic / Q000378:metabolism*; D012978:Sodium Oxybate / Q000494:pharmacology*
chemical_list: D000085:Acetates; D000227:Adenine Nucleotides; D000975:Antioxidants; D007042:Hypoxanthines; D019271:Hypoxanthine; D012978:Sodium Oxybate; D006164:Guanylthiourea; D019342:Acetic Acid
vernacular_title: Primenenie gamm-oksibutirata natriia i gutimina dlia umen'sheniia metabolicheskikh narusheniĭ v serdtse, vyzvannykh ékzotoksicheskim shokom pri otravlenii ukusnoĭ kislotoĭ.