The presence of myofibroblasts in the dermis of patients with Dupuytren's contracture. A possible source for recurrence.
Samples of skin and underlying cord obtained at dermofasciectomy for Dupuytren's contracture have been examined for the presence of smooth muscle alpha-actin (SM alpha-actin), a marker for myofibroblasts. 15 of the 20 samples stained positively for SM alpha-actin corresponding with areas of hypercellular Dupuytren's tissue. In 12 of these 15 samples SM alpha-actin-positive hypercellular Dupuytren's tissue extended into the dermis, in three cases reaching the epidermis. In eight samples, diffusely distributed cells positive for SM alpha-actin and resembling fibroblasts were seen in the dermis. These cells appeared to be separate from the Dupuytren's foci. The presence of hypercellular foci and isolated fibroblasts positive for SM alpha-actin within the dermis may explain the high recurrence rate of Dupuytren's disease after fasciectomy.
McCann
B G
BG
Department of Histopathology, Norfolk and Norwich Hospital, Norwich, UK.
Logan
A
A
Belcher
H
H
Warn
A
A
Warn
R M
RM
D000199:Actins / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D004387:Dupuytren Contracture / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012867:Skin / Q000166:cytology* / Q000378:metabolism
D000199:Actins