[Metabolism and catabolism to CO2 of [14C] gamma-aminobutyric acid conjugates with pyridoxal phosphate, nicotinate and biotin].
Pharmacokinetics and catabolism to CO2 in the mice organism and metabolic transformation by the tissues homogenates of [1-14C] GABA and its conjugates with nicotinate, pyridoxal phosphate and biotin have been studied. The permeability of nicotinoyl-GABA through the hemato-encephalic barrier was 10 times as much as the corresponding value for GABA and its conjugates with other vitamins. PLP-GABA is eliminated more rapidly from the brain in comparison with GABA, biotinyl-GABA is retained to a higher degree in kidneys, the entero-hepatic recycling takes place more actively for nicotinoyl-GABA. The latter, in contrast to biotinyl-GABA, remains unaffected by the liver, intestine mucose membrane and brain proteases and is catabolized to CO2 to a considerably lower extent as compared with GABA, perhaps due to the intestine bacterial microflora.
Rozanov
A Ia
AIa
Tishchenko
D V
DV
Zaporozhchenko
A V
AV
D000818:Animals; D001710:Biotin / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D001711:Biotransformation / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism*; D002250:Carbon Radioisotopes; D051379:Mice; D008808:Mice, Inbred CBA; D009525:Niacin / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D009928:Organ Specificity / Q000502:physiology; D011732:Pyridoxal Phosphate / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D005680:gamma-Aminobutyric Acid / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics
D002250:Carbon Radioisotopes; D002245:Carbon Dioxide; D009525:Niacin; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D001710:Biotin
Obmen i katabolizm do CO2 kon"iugatov [14C]gamma-aminomaslianoĭ kisloty s piridoksal'fosfatom, nikotinatom i biotinom.