title: Electrical impedance compared with other non-invasive bioengineering techniques and visual scoring for detection of irritation in human skin.
abstract: A new, non-invasive device, which enables local measurements of electrical impedance to a controlled depth, has been used to evaluate the degree of irritation in human skin. The results have been compared with those obtained using other non-invasive techniques, i.e. with transepidermal water loss (TEWL), electrical capacitance moist measurement (ECM), laser-Doppler flowmetry (LDF), and visual scoring. Sodium lauryl sulphate solutions (0.1-5.0%), and a blank, were applied in Finn Chambers for 24 h on the volar forearm of 10 healthy volunteers. Values were recorded before application of the test chambers, and at 1 h, 24 h, 1 week and 2 weeks after removal. Thus, both the degree of initial damage and the healing process were monitored. There was close agreement among values obtained using electrical impedance, TEWL and visual readings. Results obtained using ECM and LDF were not consistent with the other three methods. In evaluating irritation of the skin, the practical situation may influence the choice of bioengineering tools. In most circumstances, a combination of methods would be preferable.
authors.affiliation: Center for Dental Technology and Biomaterials, Karolinska Institute, NOVUM, Huddinge, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Ollmar
authors.forename: M
authors.initials: M
authors.lastname: Nyrén
authors.forename: I
authors.initials: I
authors.lastname: Nicander
authors.forename: L
authors.initials: L
authors.lastname: Emtestam
mesh_terms: D000328:Adult; D017453:Dermatitis, Irritant / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D004553:Electric Conductivity / Q000502:physiology; D017097:Electric Impedance; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008875:Middle Aged; D012867:Skin / Q000473:pathology / Q000503:physiopathology; D014870:Water Loss, Insensible / Q000502:physiology