Rat selection test with respect to laxative activity induced by barbaloin.
As individual differences in sensitivity in the laxative activity of barbaloin were observed in rats, a selection test for barbaloin (31.1 mg/kg, p.o.) was carried out between 1989 and 1991. The annual percentages of rats exhibiting a reaction positive to barbaloin were almost constant (about 57%). We propose that rats positive to barbaloin should be selected for studies on the laxative effect of barbaloin.
Ishii
Y
Y
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Tanizawa
H
H
Takino
Y
Y
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D002400:Cathartics / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results
D000873:Anthracenes; D002400:Cathartics; C045601:barbaloin