Dose-response relationship of atracurium besylate in the halothane-anaesthetised pig.
The dose response relationship for the intermediate-acting non-depolarising muscle relaxant, atracurium besylate in the pig was determined using evoked electromyography. An incremental dose technique was used in seven Large White/Landrace crossbred pigs anaesthetised with nitrous oxide and halothane. ED50 and ED95 were 510 +/- 87 micrograms kg-1 and 1150 +/- 270 micrograms kg-1, respectively. Although these values may represent an overestimate, they provide a reasonable guideline for the use of atracurium by veterinary anaesthetists.
Shorten
G D
GD
Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, Western Australia.
Gibbs
N M
NM
D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D001279:Atracurium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006221:Halothane; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects; D013552:Swine
D001279:Atracurium; D006221:Halothane