title: Genetic polymorphisms of the A and B subunits of coagulation factor XIII in the Chinese population.
abstract: Coagulation factor XIIIA and XIIIB polymorphisms in a random population sample from Chengdu in southwest China (n = 121) were studied using isoelectric focusing in polyacrylamide gels followed by immunoblotting with enzyme immunoassay. The allele frequencies were as follows: FXIIIA*1 = 0.8719, FXIIIA*2 = 0.1240, FXIIIA*3 = 0.0041; FXIIIB*1 = 0.2727, FXIIIB*2 = 0.0165, FXIIIB*3 = 0.7107. The distribution of phenotypes of FXIII agrees with the Hardy-Weinberg equilibrium. Comparing these allele frequencies with those reported in other populations, it was found that the allele frequencies of FXIIIA*1 and FXIIIB*3 in the Chinese population were higher.
authors.affiliation: Institut für Rechtsmedizin, Johannes-Gutenberg-Universität, Mainz, BRD.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Stradmann-Bellinghausen
authors.forename: P M
authors.initials: PM
authors.lastname: Schneider
authors.forename: C
authors.initials: C
authors.lastname: Rittner
mesh_terms: D000483:Alleles; D002681:China; D005176:Factor XIII / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D015151:Immunoblotting; D007525:Isoelectric Focusing; D011110:Polymorphism, Genetic
chemical_list: D005176:Factor XIII