New antiviral antibiotics, kistamicins A and B. II. Structure determination.
The structures of antiviral antibiotics kistamicins A and B have been determined by a combination of chemical degradation and spectral analysis. They are commonly composed of D-tyrosine, 3,5-dihydrophenylglycine, a biphenyl ether bis-amino acid, and a diphenyl substituted indole tris-amino acid, forming a tricyclic ring structure. Kistamicin B possessed a phenethylamide at the amino terminal of kistamicin A. They are structurally related to the nuclei of the vancomycin group antibiotics particularly to antibiotic complestatin.
Naruse
N
N
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Oka
M
M
Konishi
M
M
Oki
T
T
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides; D011487:Protein Conformation
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D010455:Peptides; C085613:kistamicin A; C085614:kistamicin B