Polymorphonuclear leukocyte functions and multiple sclerosis.
We tested peripheral blood from 60 patients with definite multiple sclerosis (MS) and 60 healthy controls for polymorphonuclear leukocyte (PMNL) functions and found significant disorders in adherence (9.07% +/- 8.18% for patients versus 28.97% +/- 5.76% for controls), chemotaxis (18.32 +/- 3.1 for patients versus 30.49 +/- 4.52 for controls), phagocytosis (73.6 +/- 25.25 for patients versus 111.2 +/- 25.7 for controls), and bactericidal action (10.35% +/- 5% for patients versus 25.09% +/- 4.82% for controls). All differences were significant (p < 0.001). We confirmed the results by retesting 3 to 8 months later. The depressed PMNL functions in MS patients may explain their increased susceptibility to infections of the respiratory, digestive, and urinary tracts.
Podikoglou
D G
DG
Department of Microbiology, Athens University Medical School, Goudi, Greece.
Lianou
P E
PE
Tsakanikas
C D
CD
Papavassiliou
J T
JT
D000328:Adult; D000368:Aged; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000150:complications; D009504:Neutrophils / Q000502:physiology*; D010585:Phagocyte Bactericidal Dysfunction / Q000209:etiology; D010587:Phagocytosis; D012016:Reference Values