Thapsigargin, a Ca(2+)-ATPase inhibitor, depletes the intracellular Ca2+ pool and induces apoptosis in human hepatoma cells.
Tsukamoto
A
A
First Department of Medicine, University of Tokyo, Japan.
Kaneko
Y
Y
D017209:Apoptosis / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D004815:Epidermal Growth Factor / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D013729:Terpenes / Q000494:pharmacology*; D019284:Thapsigargin; D014407:Tumor Cells, Cultured
D013729:Terpenes; D004815:Epidermal Growth Factor; D019284:Thapsigargin; D000252:Calcium-Transporting ATPases; D002118:Calcium