title: [Synthesis of imidazo[1,2-a]pyridine derivatives and their reactions].
abstract: By the reaction of 2-benzoylmethylimidazoles (1a, b) with polarized olefins (2, 3) in the presence of K2CO3, the corresponding imidazo[1,2-a]pyridine derivatives (4, 5) were obtained. Methylsulfinylimidazopyridine derivative (7) obtained by the reaction of 5b with m-chloroperbenzoic acid (m-CPBA), easily underwent nucleophilic substitution to give the corresponding substituted compounds (8a--e). The substitution of chloroimidazopyridine derivative (11) with nucleophiles produced the corresponding substituted compounds (12a--d).
authors.affiliation: School of Pharmaceutical Sciences, Nagasaki University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ide
authors.forename: K
authors.initials: K
authors.lastname: Katou
authors.forename: T
authors.initials: T
authors.lastname: Itou
authors.forename: C
authors.initials: C
authors.lastname: Motokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Chiyomaru
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
mesh_terms: D000475:Alkenes; D002254:Carbonates; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011188:Potassium; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D002254:Carbonates; D007093:Imidazoles; D011725:Pyridines; C037593:potassium carbonate; D011188:Potassium