title: [Anesthesia with propofol during an exacerbated course of acute intermittent porphyria].
abstract: In the eighth week of pregnancy the medical indication for induced abortion was established due to an exacerbating acute intermittent porphyria with life-threatening neurological symptoms. delta-aminolaevulinic acid and porphobilinogen were excessively increased in urine prior to the operation. Anaesthesia was induced with a bolus of propofol, alfentanil and droperidol, maintained by 67% of nitrous oxide and small bolus injections of the three drugs. The patient regained consciousness immediately after the operation, and reached full orientation and cooperativeness within five minutes. The postoperative period remained uneventful and the neurological and psychological symptoms returned to the pre-exacerbation status. Chorion gonadotropins and porphyria markers decreased within the next four weeks accompanied by a simultaneously progressing clinical improvement. The use of propofol and the other drugs appears justified even in exacerbated porphyria.
authors.affiliation: Abteilung für Anästhesie und Intensivtherapie, Philipps-Universität Marburg.
authors.forename: U F
authors.initials: UF
authors.lastname: Kroh
authors.forename: M
authors.initials: M
authors.lastname: Frank
authors.forename: C
authors.initials: C
authors.lastname: Schwerk
authors.forename: M O
authors.initials: MO
authors.lastname: Doss
mesh_terms: D000032:Abortion, Therapeutic; D000328:Adult; D000771:Anesthesia, Intravenous; D000773:Anesthesia, Obstetrical; D005260:Female; D006801:Humans; D017118:Porphyria, Acute Intermittent; D011247:Pregnancy; D011248:Pregnancy Complications; D015742:Propofol
chemical_list: D015742:Propofol
vernacular_title: Anästhesie mit Propofol bei einem exazerbierten Verlauf der akuten intermittierenden Porphyrie.