Press-coated tablets for time-programmed release of drugs.
A new dry-coated device for the release of drug after a programmable period of time is proposed. It is intended to be used mainly in the therapy of those diseases which depend on circadian rhythms. Some core formulations, characterized by different release rates and mechanisms (containing diltiazem hydrochloride or sodium diclofenac as model drugs), were coated by compression with different polymeric barrier layers (press-coated systems). The shell formulations tested contained either gellable or erodible polymers. The dissolution profiles of uncoated cores and press-coated devices were compared. The gellable and/or erodible characteristics (properties) of the barrier formulations were also examined by means of a penetrometer. The coatings prevent drug release from the core until the polymeric shell is completely eroded or swollen. This delay in release start is not influenced by the core composition and depends only on the shell formulation. Except for the time-lag, the release kinetics of the drug contained in the core are not significantly influenced by the presence of the erodible barrier, but can be widely modulated using a swellable polymeric shell.
Conte
U
U
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
Maggi
L
L
Torre
M L
ML
Giunchedi
P
P
La Manna
A
A
D002940:Circadian Rhythm; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives; D011108:Polymers; D013607:Tablets
D003692:Delayed-Action Preparations; D011108:Polymers; D013607:Tablets; D065347:Hypromellose Derivatives; D008747:Methylcellulose