[The immunity indices of BALB/c mice immunized with an inactivated antigen of the Machupo virus].
The paper presents the data characterizing parameters of specific and nonspecific immunity in BALB/c mice immunized with gamma-ray-inactivated Machupo virus antigen or its formalinized antigen. The gamma-ray inactivated preparation was shown to be more immunogenic for BALB/c mice. A certain relationship between the time course of activity of nonspecific immunity factors in the immunized animals and the protective activity of the preparation under study was also noted. The decisive role of the T-cell part of the immune system was demonstrated in the resistance of this model animal to Machupo virus infection.
Ignat'ev
G M
GM
Tverdokhlebov
A V
AV
Kaliberov
S A
SA
Patrusheva
I V
IV
Kashentseva
E A
EA
Vorob'eva
M S
MS
D000818:Animals; D000833:Animals, Suckling; D000917:Antibody Formation; D000956:Antigens, Viral / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D006477:Arenaviruses, New World / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D006478:Hemorrhagic Fever, American / Q000276:immunology* / Q000517:prevention & control; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007114:Immunization / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000276:immunology / Q000528:radiation effects; D014765:Viral Vaccines / Q000276:immunology / Q000528:radiation effects
D000956:Antigens, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
Pokazateli immuniteta u mysheĭ linii BALB/c, immunizirovannykh inaktivirovannym antigenom virusa Machupo.