Iron induced oxidative stress and mitochondrial dysfunction: relevance to Parkinson's disease.
Inactivation of the mitochondrial respiratory chain in response to iron-induced oxidative stress has been studied in cultured cells. Iron loading resulted in malonaldehyde production, decreased levels of glutathione and reduced specific activities of both complexes I and IV of the respiratory chain. These results are discussed with respect to idiopathic Parkinson's disease, which is associated with increased iron levels and a specific decrease in complex I activity in the substantia nigra.
Harley
A
A
Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
Cooper
J M
JM
Schapira
A H
AH
D000818:Animals; D004579:Electron Transport / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D007501:Iron / Q000494:pharmacology*; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects*; D010084:Oxidation-Reduction; D016716:PC12 Cells; D010300:Parkinson Disease / Q000503:physiopathology*; D013378:Substantia Nigra / Q000187:drug effects* / Q000378:metabolism
D008315:Malondialdehyde; D007501:Iron; D005978:Glutathione