[Effects of 3,6-dimethylamino-dibenzopyriodonium formiate on action potential and slow inward calcium current in isolated guinea pig ventricular myocytes].
The effects of 3,6-dimethylamino-dibenzopyriodonium formiate (IHC-64) on action potential and slow inward calcium current (I(si)) were investigated in isolated guinea pig ventricular myocytes using whole cell voltage clamp recording. IHC-64 (20 and 200 mumol/L) was shown to markedly decrease APD20 and APD90. However, in the presence of nisoldipine, no obvious effects of IHC-64 on APD20 could be detected. Under voltage clamp conditions, IHC-64 (20 and 200 mumol/L) caused a significant decrease in I(si). The results indicate that IHC-64 can block the calcium channels in isolated guinea pig ventricular myocytes.
Cui
Y
Y
Department of Pharmacology, Fourth Military Medical University, Xi' an.
Tan
Y H
YH
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000166:cytology*; D015737:Nisoldipine / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D011725:Pyridines; D015737:Nisoldipine; C053584:IHC 64