[Sweet's syndrome (acute febrile neutrophilic dermatosis)].
The clinical presentation and the relation with malignancy of acute febrile neutrophilic dermatosis in 7 patients are described. The syndrome is characterised by fever, neutrophilic granulocytosis, painful erythematous plaques and typical histology consisting of a dense dermal infiltrate of mature neutrophils. The idiopathic form (80% of reported patients) usually follows a viral infection. The secondary form (20% of reported patients) is associated with a malignancy, which in the large majority (85%) is a hematologic disorder (this was the case in 3 of the 7 patients); the course of the syndrome may then be serious. The secondary form of the disease may be associated with an exacerbation of a preexistent malignancy, as was seen in 2 of the 3 patients. If the syndrome runs a serious course the treatment consists of corticosteroid administration.
van der Hulst
R W
RW
Afd. Algemene Interne Geneeskunde, Academisch Ziekenhuis, Leiden.
Tieben
L M
LM
Gerritsen
J J
JJ
Bruijn
J A
JA
Kluin-Nelemans
J C
JC
D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
Het syndroom van Sweet (acute febriele neutrofiele dermatose).