Intracarotid cisplatin chemotherapy for high-grade astrocytomas.
Twenty-five patients with malignant astrocytomas (grade III and IV) were treated with intraarterial infusions of cisplatin at 4/8 weeks intervals. Of the 23 evaluable patients, none had a complete response, 1 (4.3%) had a probable response (unequivocal improvement in the neurological examination and CT evidence of a decrease in tumor size), 15 (65.2%) had stable disease, and 7 (30.5%) had a progression (unequivocal worsening of both the neurological examination and the CT scan). Twenty-one of the 25 patients exhibited some degree of toxicity; the only two serious complications observed were neurological and retinal.
Brambilla Bas
M
M
Department of Neurosurgery, S. Corona Hospital, Pietra Ligure, Italy.
Boccardo
M
M
D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D002945:Cisplatin