title: Interstitial pneumonitis possibly due to mitoxantrone.
abstract: A 41-year-old patient with chronic myelogenous leukemia in the accelerated phase was treated with mitoxantrone. She developed pyrexia 7 days after receiving the third administration of mitoxantrone. After 3 more days, she experienced dry cough and dyspnea. Bilateral fine crackles were audible, but no signs of heart failure were found. A chest X-ray film revealed diffuse reticulogranular infiltrates bilaterally. An increase in the prednisolone dosage led to an improvement. Specimens of the bronchoalveolar lavage revealed an increase in CD4-/CD8- lymphocytes. The peripheral lymphocytes also expressed neither CD4 nor CD8. Specimens of a transbronchial lung biopsy disclosed thickening of the alveolar wall with infiltration of lymphoid cells.
authors.affiliation: First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsukawa
authors.forename: J
authors.initials: J
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Aiso
authors.forename: T
authors.initials: T
authors.lastname: Hagiwara
authors.forename: T
authors.initials: T
authors.lastname: Hayama
authors.forename: T
authors.initials: T
authors.lastname: Ohshima
authors.forename: T
authors.initials: T
authors.lastname: Horie
authors.forename: Y
authors.initials: Y
authors.lastname: Kitami
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015465:Leukemia, Myeloid, Accelerated Phase / Q000188:drug therapy; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008942:Mitoxantrone / Q000009:adverse effects*
chemical_list: D008942:Mitoxantrone