title: A probabilistic rule-based expert system.
abstract: This paper explores a medical expert system combining techniques of Bayesian network modelling with ideas of weighted inference rules. The weights of the individual rules can be estimated objectively from a training set of actual cases; and they can be used in a Monte Carlo stimulation to estimate objectively conditional probabilities of diagnosis given particular combinations of symptoms. The paper describes and evaluates a medical expert system built according to this design. The diagnostic accuracy of the program was found to be similar to that obtained through the usual application of Bayes theorem with the assumption of conditional independence of symptoms given disease, even though the Bayesian classifier has more than 70 times as many numerical parameters. The method may be promising in cases where small training sets do not permit accurate estimation of large numbers of parameters.
authors.affiliation: Programming Research Group, Oxford University Computing Laboratory, UK.
authors.forename: B S
authors.initials: BS
authors.lastname: Todd
authors.forename: R
authors.initials: R
authors.lastname: Stamper
authors.forename: P
authors.initials: P
authors.lastname: Macpherson
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D001499:Bayes Theorem; D003936:Diagnosis, Computer-Assisted; D005103:Expert Systems; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis*; D006801:Humans; D015233:Models, Statistical; D009010:Monte Carlo Method; D011237:Predictive Value of Tests