title: Total pelvic exenteration for locally advanced rectal carcinoma.
abstract: Total pelvic exenteration was performed in 31 patients (30 males and 1 female) who had rectal cancers involving adjoining pelvic structures. Twenty-nine patients had primary tumors and two had recurrent diseases after previous abdominoperineal resection. Preoperative irradiation was used in nine patients with fixed tumors. When performing the surgical procedure, we also actively employed lateral node dissection to make the operation more radical. Three patients (one with primary tumor and two with recurrent) underwent the exenteration with partial sacrectomy because of the sacral involvement and they all died of local failure within 15 months. The overall 5-year survival rate was 52 percent for all patients and 56 percent for those who had primary tumors. The results suggest that total pelvic exenteration with lateral node dissection should be performed for locally advanced rectal cancer if the tumor is not completely fixed to the pelvic wall and preoperative irradiation should be used to convert a fixed tumor to a resectable one.
authors.affiliation: Department of Surgery, Cancer Hospital, Shanghai Medical University, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Liu
authors.forename: Y N
authors.initials: YN
authors.lastname: Wang
authors.forename: W Q
authors.initials: WQ
authors.lastname: Zhu
authors.forename: W L
authors.initials: WL
authors.lastname: Gu
authors.forename: H
authors.initials: H
authors.lastname: Fu
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010385:Pelvic Exenteration / Q000379:methods*; D011300:Preoperative Care; D011471:Prostatic Neoplasms / Q000473:pathology; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000473:pathology