Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.
A 68-year-old woman with parkinsonism showed cortical myoclonus and seizures under antiparkinsonian medication. Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures. EEG was abnormal and somatosensory-evoked potentials (SEPs) showed giant SEPs, transcortical reflex (C reflex) and jerk locked potentials. Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA). We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.
Yoshida
K
K
Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan.
Moriwaka
F
F
Matsuura
T
T
Hamada
T
T
Tashiro
K
K
D000368:Aged; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D014635:Valproic Acid / Q000008:administration & dosage
D007980:Levodopa; D014635:Valproic Acid