title: Furosemide, bumetanide, and ethacrynic acid.
abstract: Furosemide and, less commonly, bumetanide and ethacrynic acid are potent diuretics administered to horses for a variety of reasons, including prophylaxis of exercise-induced pulmonary hemorrhage. These drugs affect urine volume and composition, and furosemide has marked effects on plasma volume and composition and on systemic hemodynamics at rest and during exercise.
authors.affiliation: Department of Veterinary Clinical Sciences, Ohio State University College of Veterinary Medicine, Columbus.
authors.forename: K W
authors.initials: KW
authors.lastname: Hinchcliff
authors.forename: L A
authors.initials: LA
authors.lastname: Mitten
mesh_terms: D000818:Animals; D002034:Bumetanide / Q000493:pharmacokinetics / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects; D004300:Doping in Sports; D004976:Ethacrynic Acid / Q000493:pharmacokinetics / Q000494:pharmacology; D005665:Furosemide / Q000493:pharmacokinetics / Q000494:pharmacology*; D006736:Horses / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects; D010953:Plasma Volume / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
chemical_list: D002034:Bumetanide; D005665:Furosemide; D004976:Ethacrynic Acid