Comparison of plasma pancreastatin and GAWK concentrations, presumed processing products of chromogranin A and B, in plasma of patients with pancreatic islet cell tumors.
Plasma pancreastatin (PST) and GAWK, peptides processed from chromogranin A and B, were elevated in patients with various neuroendocrine tumors. In the present study, we measured plasma PST- and GAWK-like immunoreactivity (LI) concentrations in 12 patients with pancreatic islet cell tumors and evaluated them as a marker for these tumors. We also performed the gel filtration of the plasma from a gastrinoma patient and investigated the processing of PST and GAWK in plasma. Elevation of plasma PST-LI was found in 4 of 12 patients (33%) and elevation of plasma GAWK-LI was found in 6 of 12 patients (50%). A significant correlation was not found between plasma PST- and GAWK-LI concentrations of the patients. In the gel permeation chromatography of the plasma from a gastrinoma patient, PST-LI composed of a single peak but GAWK-LI composed of several components with wide range molecular weights.
Yasuda
D
D
Department of Gastroenterology, National Kyushu Cancer Center, Fukuoka, Japan.
Iguchi
H
H
Funakoshi
A
A
Wakasugi
H
H
Sekiya
K
K
Misawa
T
T
Tateishi
K
K
Bloom
S R
SR
Nawata
H
H
D007516:Adenoma, Islet Cell / Q000097:blood*; D000595:Amino Acid Sequence; D002850:Chromatography, Gel; D053379:Chromogranin A; D053378:Chromogranin B; D002864:Chromogranins / Q000378:metabolism*; D015408:Gastrinoma / Q000097:blood; D006801:Humans; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000097:blood*; D010187:Pancreatic Hormones / Q000097:blood*; D010190:Pancreatic Neoplasms / Q000097:blood*
C506150:CHGA protein, human; D053379:Chromogranin A; D053378:Chromogranin B; D002864:Chromogranins; D009419:Nerve Tissue Proteins; D010187:Pancreatic Hormones; C050836:pancreastatin; C044449:GAWK