title: A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke.
abstract: Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P < 0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P < 0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.
authors.affiliation: Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia.
authors.forename: P L
authors.initials: PL
authors.lastname: Morris
authors.forename: H S
authors.initials: HS
authors.lastname: Mayberg
authors.forename: K
authors.initials: K
authors.lastname: Bolla
authors.forename: D F
authors.initials: DF
authors.lastname: Wong
authors.forename: R F
authors.initials: RF
authors.lastname: Dannals
authors.forename: S E
authors.initials: SE
authors.lastname: Starkstein
authors.forename: R G
authors.initials: RG
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D011985:Receptors, Serotonin