Argyrophil cell hyperplasia and a carcinoid tumour in the stomach of a patient with sporadic Zollinger-Ellison syndrome.
In the rat, hypergastrinaemia induced by drug treatment with omeprazole or potent H2-receptor antagonists leads to the development of gastric enterochromaffin-like cell carcinoids. In man, gastric carcinoids induced by hypergastrinaemia have been described only in patients with chronic atrophic gastritis type A and in patients with the multiple endocrine neoplasia syndrome type 1. This patient with Zollinger-Ellison syndrome without gastric mucosal atrophy and without evidence of the multiple endocrine neoplasia syndrome developed an argyrophil gastric carcinoid tumour. This observation indicates that hypergastrinaemia in the sporadic Zollinger-Ellison-syndrome may induce gastric carcinoids.
Feurle
G E
GE
Stadtkrankenhaus Neuwied, University of Bonn, Germany.
D000328:Adult; D002276:Carcinoid Tumor / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood; D006801:Humans; D013274:Stomach Neoplasms / Q000097:blood / Q000209:etiology*; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000150:complications* / Q000473:pathology
D005755:Gastrins