Epithelial tumours induced by a herpesvirus oncogene in transgenic mice.
To investigate the role of herpesviral genes in tumourigenesis, transgenic mice were generated expressing STP-C, a transformation associated protein of the lymphoma inducing herpesvirus saimiri. Epithelial tumours developed in the salivary gland, pancreas, thymus and liver of transgenic mice within the first weeks of life. Thus, the target cells for tumour formation in the transgenic mice were surprisingly different from those of the herpesvirus from which the oncogene was derived. Our results identify STP-C as a herpesvirus oncogene sufficient for tumour induction without the cooperation of other viral gene products. Furthermore, the results demonstrate pleiotropic transforming capabilities of the STP-C oncogene and suggest that the specificity of lymphoma induction by the virus is determined by factors other than the oncogene itself.
Murphy
C
C
European Molecular Biology Laboratory, Heidelberg, Germany.
Kretschmer
C
C
Biesinger
B
B
Beckers
J
J
Jung
J
J
Desrosiers
R C
RC
Müller-Hermelink
H K
HK
Fleckenstein
B W
BW
Rüther
U
U
D000818:Animals; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D004848:Epithelium / Q000473:pathology; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics*; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000209:etiology*; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D009857:Oncogenes; D010641:Phenotype
D009856:Oncogene Proteins, Viral; C072817:STP-C488 protein, Herpesvirus saimiri