Antibody response to a two-dose influenza vaccine regimen in adult lymphoma patients on chemotherapy.
A study was conducted to determine if a two-dose regimen of influenza vaccine would enhance the immunologic response of 41 patients with lymphoma receiving chemotherapy. Hemagglutinin-inhibiting antibody responses to influenza A/H1N1, A/H3N2 and B virus occurred in 32%, 24% and 20% of patients following one dose, and in 49%, 41% and 46% of patients following two doses, respectively. Responses to one or more vaccine components occurred in 42% of patients after one dose and in 71% after two doses. Fifty percent of the patients who did not respond after one dose responded after two doses. A two-dose regimen of influenza immunization may significantly enhance the response rate of cancer patients receiving chemotherapy.
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Department of Medical Specialities, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Whimbey
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E
Elting
L
L
Couch
R
R
Cabanillas
F
F
Bodey
G
G
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D008223:Lymphoma / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007252:Influenza Vaccines