title: Fine-needle aspiration cytology of silicone granulomas in the augmented breast.
abstract: We studied 12 aspirates from 10 patients who underwent diagnostic fine-needle aspiration cytology (FNAC) of an augmented or reconstructed breast. Six patients were augmented with silicone gel-filled implants and four patients had silicone liquid injections. FNAC indications included a painful or suspicious mass. Excisional biopsy was performed in six cases after FNAC. The findings of eight cases included modestly cellular smears composed of loosely cohesive histiocytes containing vacuoles of various sizes. Multinucleated foreign body giant cells, fragments of dense, amorphous fibrous tissue, and fibroblast nuclei stripped of cytoplasm were also present. Two patients showed a mixture of inflammatory cells characteristic of intramammary lymph nodes or lymphoid aggregates. We conclude that silicone granulomas of the breast show a characteristic set of findings on FNAC which enable a cytopathologist to render a specific diagnosis given an appropriate history of breast augmentation.
authors.affiliation: Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston.
authors.forename: L G
authors.initials: LG
authors.lastname: Dodd
authors.forename: N
authors.initials: N
authors.lastname: Sneige
authors.forename: G P
authors.initials: GP
authors.lastname: Reece
authors.forename: B
authors.initials: B
authors.lastname: Fornage
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001941:Breast Diseases / Q000209:etiology / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects*; D008875:Middle Aged; D019736:Prostheses and Implants / Q000009:adverse effects*; D012828:Silicones
chemical_list: D012828:Silicones