[Study on dissolution rate and bioavailability of norfloxacin capsule by UV-spectrophotometry].
The dissolution rates and bioavailability of norfloxacin in seven batches of norfloxacin capsules produced by five pharmaceutical factories were studied with rotating basket and UV-spectrophotometry. The results showed that the T50, Td and m of the samples had obvious differences, and the correlation between the dissolution rate and bioavailability differed very obviously. The method used is simple and convenient. So UV-spectrophotometry is one of the methods for the assay of norfloxacin preparations in vitro and in vivo.
Ke
Z
Z
Zhang
Z
Z
Gong
W
W
Wang
L
L
D001682:Biological Availability; D002214:Capsules; D005260:Female; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000493:pharmacokinetics*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D002214:Capsules; D009643:Norfloxacin