title: Anaphylactoid reaction with suramin.
abstract: Suramin, a drug used to treat parasitic diseases, is currently being investigated as a treatment for metastatic prostate cancer. A 73-year-old man had an anaphylactoid reaction following the first dose of suramin. It was treated successfully with epinephrine, diphenhydramine, and hydrocortisone. Investigators should be aware of the possibility of such a reaction with parenteral administration of this drug.
authors.affiliation: Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: A
authors.initials: A
authors.lastname: Thibault
authors.forename: W D
authors.initials: WD
authors.lastname: Figg
authors.forename: M R
authors.initials: MR
authors.lastname: Cooper
authors.forename: S A
authors.initials: SA
authors.lastname: Prindiville
authors.forename: A O
authors.initials: AO
authors.lastname: Sartor
authors.forename: D J
authors.initials: DJ
authors.lastname: Headlee
authors.forename: C E
authors.initials: CE
authors.lastname: Myers
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013498:Suramin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D013498:Suramin