title: Active compression-decompression resuscitation: effects on pulmonary ventilation.
abstract: This investigation was designed to test the hypothesis that active compression-decompression resuscitation is able to independently provide improved levels of minute ventilation when compared to high-impulse manual cardiopulmonary resuscitation (CPR). Eight adult beagles (10-15 kg) were studied after induction of ventricular fibrillation. Single 1-min CPR trials were performed while arterial blood gases and minute ventilation were monitored. ACD and high-impulse CPR were performed sequentially, in random order at compression rates of 120/min, 1.5- to 2.0-inch compression depth and 50% duty cycle. Minute ventilation averaged 3.6 +/- 0.77 1 during high-impulse CPR and increased to 4.9 +/- 0.88 1 during ACD CPR. No difference was observed in arterial blood pH, PCO2, or PO2 when ACD was compared to high-impulse CPR. We conclude that ACD CPR provides improved levels of minute ventilation when compared to high-impulse manual CPR in this canine model of cardiac arrest. Improved minute ventilation may contribute to the mechanism of improved cardiopulmonary hemodynamics reported in previous investigations of ACD CPR. Further investigation is warranted to determine the effects of ACD CPR on pulmonary ventilation in human subjects after cardiac arrest.
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco.
authors.forename: K J
authors.initials: KJ
authors.lastname: Tucker
authors.forename: J H
authors.initials: JH
authors.lastname: Khan
authors.forename: M A
authors.initials: MA
authors.lastname: Savitt
mesh_terms: D000818:Animals; D016887:Cardiopulmonary Resuscitation / Q000295:instrumentation / Q000379:methods*; D004285:Dogs; D006323:Heart Arrest / Q000628:therapy*; D007442:Intubation, Intratracheal; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000628:therapy