title: Efficacy of in vitro stone fragmentation by extracorporeal, electrohydraulic, and pulsed-dye laser lithotripsy.
abstract: Fragmentation has become the standard therapy for urinary calculi in the modern era. Stone fragility as well as position and size are important for the determination of a treatment program. To compare the efficacy of stone fragmentation, seven kinds of human urinary calculi with known composition (calcium oxalate monohydrate and dihydrate, dibasic calcium phosphate, uric acid, struvite, calcium phosphate, and cystine) were treated by three fragmentation techniques commonly used, namely extracorporeal shock wave (SWL), electrohydraulic (EHL), and pulsed-dye laser lithotripsy. Uric acid, calcium oxalate dihydrate, and calcium phosphate stones could be destroyed easily by any of these methods. Struvite was soft but sticky and not easy to break into tiny particles. Both dibasic calcium phosphate and calcium oxalate monohydrate stones were resistant to the laser and EHL; SWL is the treatment of choice. For cystine stones, none of the treatments was satisfactory; SWL was the only way to break them into large pieces.
authors.affiliation: Department of Surgery, Veterans General Hospital-Kaohsiung, Taipei, Taiwan, Republic of China.
authors.forename: T T
authors.initials: TT
authors.lastname: Wu
authors.forename: T H
authors.initials: TH
authors.lastname: Hsu
authors.forename: M T
authors.initials: MT
authors.lastname: Chen
authors.forename: L S
authors.initials: LS
authors.lastname: Chang
mesh_terms: D002129:Calcium Oxalate / Q000032:analysis; D002130:Calcium Phosphates / Q000032:analysis; D003553:Cystine / Q000032:analysis; D006801:Humans; D008096:Lithotripsy / Q000379:methods / Q000592:standards*; D017602:Lithotripsy, Laser / Q000379:methods / Q000592:standards*; D017616:Magnesium Compounds / Q000032:analysis; D010710:Phosphates / Q000032:analysis; D000069877:Struvite; D014527:Uric Acid / Q000032:analysis; D014545:Urinary Calculi / Q000737:chemistry / Q000473:pathology / Q000628:therapy*
chemical_list: D002130:Calcium Phosphates; D017616:Magnesium Compounds; D010710:Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D002129:Calcium Oxalate; D014527:Uric Acid; D003553:Cystine; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D000069877:Struvite; C485829:calcium phosphate, dibasic, anhydrous