title: Necessary conditions for the pi-electron delocalization in enamino-type muscle relaxants.
abstract: Two necessary conditions have been proposed for the pi-electron delocalization across four bonds in bis-quaternary bromides of enamino spiro-ketal-type compounds. Dynamic NMR data analysis of these compounds suggests that pi-electron delocalization takes place if the first atom is nitrogen and the fourth atom is either nitrogen or oxygen [i.e., N+ = C-C = N (or O)]. The second condition is that the end atoms of the four-bond system should not be the terminal group.
authors.affiliation: BOC Group, Inc., Technical Center, Murray Hill, NJ 07974.
authors.forename: A L
authors.initials: AL
authors.lastname: Cholli
authors.forename: M L
authors.initials: ML
authors.lastname: Lau
authors.forename: K
authors.initials: K
authors.lastname: Gala
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004583:Electrons; D007097:Imines / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009467:Neuromuscular Depolarizing Agents / Q000737:chemistry* / Q000494:pharmacology; D003473:Neuromuscular Nondepolarizing Agents / Q000737:chemistry* / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013696:Temperature; D013816:Thermodynamics
chemical_list: D007097:Imines; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D013141:Spiro Compounds