Interstitial lung disease--an underdiagnosed side effect of chlorambucil?
A case of recurrent interstitial pneumonia following re-exposure to chlorambucil therapy for chronic lymphocytic leukemia is presented. Chlorambucil is a rare cause of pulmonary disease. The onset of symptoms may occur after only some weeks or after up to several years with no dose-response relationship. Therapy involves the discontinuation of the offending drug and the administration of steroids. The prognosis is poor, with a mortality greater than 50%.
Mohr
M
M
Abteilung für Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Germany.
Kingreen
D
D
Rühl
H
H
Huhn
D
D
D002699:Chlorambucil / Q000009:adverse effects*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000628:therapy; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*; D011994:Recombinant Proteins
D007370:Interferon Type I; D011994:Recombinant Proteins; D002699:Chlorambucil; D011241:Prednisone