[Interleukin 2 (IL-2) and its receptor (IL-2R) in healthy individuals and with various disease states].
IL-2 is a cytokine that plays a central role in immune response. It stimulates cellular as well as humoral reactivity. The effect of IL-2 depends on the interaction with its receptor. Recent reports have documented that high affinity interleukin-2 receptors consist of two distinct IL-2 binding proteins, one being alpha chain (p55) and the other being IL-2 beta chain (p75). Expression of the alpha chain or the beta chain alone allows for low affinity or intermediate affinity IL-2 binding, respectively. Alpha receptor is present on activated cells, beta chain is present on resting cells. Decreased production of IL-2 and decreased expression of IL-2 receptor (IL-2R) after stimulation was found in primary and secondary immune deficiencies. Leukemic cells in adult T cell leukemia and hairy cell leukemia express markedly large numbers of IL-2 receptors. Since IL-2 receptors are present on malignant cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T cell leukemia are treated with monoclonal antibody that binds to IL-2 receptor.
Mazur
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Katedry i Kliniki Hematologii i Chorób Rozrostowych Krwi A.M., Wrocławiu.
Frydecka
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D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology* / Q000378:metabolism; D007943:Leukemia, Hairy Cell / Q000276:immunology; D015458:Leukemia, T-Cell / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000737:chemistry / Q000378:metabolism*; D012016:Reference Values
D000911:Antibodies, Monoclonal; D007376:Interleukin-2; D015375:Receptors, Interleukin-2
Interleukina 2 (IL-2) i jej receptor (IL-2r) u osób zdrowych i w róznych stanach chorobowych.