Regional myocardial ischaemia and diastolic dysfunction in hypertensive heart disease.
In patients with systemic hypertension there is progressive left ventricular remodelling characterized mainly by left ventricular hypertrophy accompanied by abnormal diastolic ventricular function. Regional ischaemia, secondary to abnormal myocardial perfusion may explain in part the decrease in relaxation and compliance of the hypertrophied left ventricle. Treatment with anti-ischaemia drugs, such as beta-blockers or calcium channel blockers, improve left ventricular diastolic function.
López Sendón
J
J
Coronary Care Unit, Hospital La Paz, Universidad Autónoma de Madrid, Spain.
D003971:Diastole / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D016277:Ventricular Function, Left