title: Non-cardia gastric adenocarcinoma and Helicobacter pylori infection.
abstract: The seroprevalence of IgG antibodies to Helicobacter pylori (Hp-Ab) was studied in 47 patients (29M, 18F, mean age +/- SD: 62.44 +/- 12.63 years) with non-cardia gastric carcinoma using an enzyme-linked immunosorbent assay. Controls were: a) 50 healthy people well-matched with the cancer patients; b) 50 patients with dyspepsia well matched with the cancer patients. Hp-Ab were detected in 72.3% of patients with gastric carcinoma, in 68% of healthy people and in 88% of dyspeptics. No significant associations were found between H. pylori infection and gastric cancer patients as a whole (odds ratio: 1.23, 95% CI: 0.514-2.95). In addition, no significant associations were found between H. pylori infection and the various subsets of cancer patients. These findings do not support an association between H. pylori infection and non-cardia gastric carcinoma in Greece.
authors.affiliation: Department of Pathologic Physiology, Medical School, University of Athens, Laikon General Hospital, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Archimandritis
authors.forename: J
authors.initials: J
authors.lastname: Bitsikas
authors.forename: M
authors.initials: M
authors.lastname: Tjivras
authors.forename: E
authors.initials: E
authors.lastname: Anastasakou
authors.forename: N
authors.initials: N
authors.lastname: Tsavaris
authors.forename: D
authors.initials: D
authors.lastname: Kalogeras
authors.forename: P
authors.initials: P
authors.lastname: Davaris
authors.forename: A
authors.initials: A
authors.lastname: Fertakis
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology; D016481:Helicobacter Infections / Q000276:immunology / Q000473:pathology*; D016480:Helicobacter pylori / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G