title: Systemic diseases associated with intermediate uveitis.
abstract: BACKGROUND
  Intermediate uveitis is characterized by vitreal inflammation with associated inflammation of the vitreous base and peripheral anterior retina and choroid. It may be found as an isolated and idiopathic condition or in association with systemic disorders such as multiple sclerosis and sarcoidosis.
  
  
  OBJECTIVE
  To identify the clinical features of intermediate uveitis and assess its association with systemic diseases.
  
  
  METHODS
  Retrospective study of 83 patients presenting with intermediate uveitis between 1970 and 1991.
  
  
  RESULTS
  Evidence of systemic disorders was found in 26 of 83 patients (31.3%). Of these 26 patients, 10 had presumed sarcoidosis, 6 had multiple sclerosis, 2 had isolated optic neuritis, 2 had inflammatory bowel disease, 4 had isolated thyroid abnormalities, and 2 had histories suggestive of Epstein-Barr virus infection. Associated ocular findings included cystoid macular edema, peripheral retinal perivascular sheathing, cataracts, posterior vitreous detachment, fine keratic precipitates, preretinal macular fibrosis, retinal tears, retinal detachment, and optic disc edema.
  
  
  CONCLUSIONS
  Patients with intermediate uveitis may have associated systemic diseases and should have careful follow-up with regular systemic evaluation.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Foundation, OH 44195.
authors.forename: S A
authors.initials: SA
authors.lastname: Boskovich
authors.forename: C Y
authors.initials: CY
authors.lastname: Lowder
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: F A
authors.initials: FA
authors.lastname: Gutman
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005128:Eye Diseases / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications; D009902:Optic Neuritis / Q000150:complications; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications; D013959:Thyroid Diseases / Q000150:complications; D014412:Tumor Virus Infections / Q000150:complications; D015867:Uveitis, Intermediate / Q000150:complications* / Q000175:diagnosis