[Effect of structural features of nitro-derivatives of fluorenone and biphenyl on frameshift mutagenesis in tester strains of Salmonella typhimurium].
Comparative mutagenic activity of 7 derivatives of biphenyl and fluorenone, 4,4'-dinitrobiphenyl-2,2'-dicarboxylic acid; 4,4',6,6'-tetranitrobiphenyl-2,2'-dicarboxylamide; 2-nitrofluorenone-5-carboxylic acid; 2,7-dinitrofluorenone-5-carboxylic acid; 2,7-dinitrofluorenone-5-carboxylamide; 2-nitrofluorenone-5,7-dicarboxylic acid; 2,4-dinitrofluorenone-5,7-dicarboxylic acid was studied. The highest activity was demonstrated for 2,7-DNF-5-KA and 2,7-DNF-5,7-DK which induced frameshift mutations in the tester strains Salmonella typhimurium TA1537, TA97, TA1538, TA98. High mutagenicity of these compounds is correlated with the position of nitro-groups and the effects of carboxylic and carboxyamide groups.
Abilev
S K
SK
Liubimova
I K
IK
Migachev
G I
GI
D000577:Amides / Q000633:toxicity; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000633:toxicity; D002264:Carboxylic Acids / Q000633:toxicity; D005449:Fluorenes / Q000737:chemistry* / Q000633:toxicity; D016368:Frameshift Mutation; D015394:Molecular Structure; D009574:Nitro Compounds / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics*; D013329:Structure-Activity Relationship
D000577:Amides; D001713:Biphenyl Compounds; D002264:Carboxylic Acids; D005449:Fluorenes; D009574:Nitro Compounds; C010574:biphenyl; C028401:9-fluorenone
Vliianie strukturnykh osobennosteĭ nitroproizvodnykh fluorenona i bifenila na freĭmshift-mutagenez v testernykh shtammakh Salmonella typhimurium.