[Formation of a structural isomer of platelet activating factor during acetylation of 1-alkyl-sn-glycero-3-phosphocholine].
In studying acetylation of 1-alkyl-sn-glycero-3-phosphocholine (lyso PAF) with acetic anhydride, a key step of the platelet activating factor (PAF) synthesis, we have found that in the presence of triethylamine or 4-dimethylaminopyridine some 1-alkyl-3-acetyl-sn-glycero-2-phosphocholine as an admixture to PAF formed, whereas the acid catalysed reaction resulted in isomerically pure PAF. The mechanism of the reaction leading to the PAF structural isomer is discussed.
Chupin
V V
VV
Ostapenko
O V
OV
Klykov
V N
VN
Anikin
M V
MV
Serebrennikova
G A
GA
D000107:Acetylation; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000737:chemistry
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor
Obrazovanie strukturnogo izomera faktora aktivatsii trombotsitov pri atsetilirovanii 1-alkil-sn-glitsero-3-fosfokholina.