title: The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
authors.affiliation: Drug Development Section, Institute of Cancer Research, Sutton, Surrey, U.K.
authors.forename: R
authors.initials: R
authors.lastname: Kimbell
authors.forename: A L
authors.initials: AL
authors.lastname: Jackman
authors.forename: F T
authors.initials: FT
authors.lastname: Boyle
authors.forename: A
authors.initials: A
authors.lastname: Hardcastle
authors.forename: W
authors.initials: W
authors.lastname: Aherne
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D003856:Deoxyuracil Nucleotides / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D005493:Folic Acid Antagonists / Q000633:toxicity*; D007939:Leukemia L1210 / Q000201:enzymology*; D051379:Mice; D011799:Quinazolines / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000633:toxicity*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D013942:Thymine Nucleotides / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D003856:Deoxyuracil Nucleotides; D005493:Folic Acid Antagonists; D011799:Quinazolines; D013876:Thiophenes; D013942:Thymine Nucleotides; D005492:Folic Acid; C007267:2'-deoxyuridylic acid; D013940:Thymidylate Synthase; C068874:raltitrexed; C059966:ICI 198583; C024157:thymidine 5'-triphosphate