Repeated complete remission in a patient with acute promyelocytic leukemia after treatment with 13-cis-retinoic acid first and with all-trans-retinoic acid in relapse.
The use of retinoic acid is a new approach in the treatment of acute promyelocytic leukemia. We outline the therapy in a 61-year-old patient with acute promyelocytic leukemia who had not responded to standard chemotherapy but in whom the administration of 13-cis-retinoic acid resulted in complete remission for 24 months. In relapse the patient was treated with all-trans-retinoic acid in combination with two cycles of daunorubicin and cytosine arabinoside and achieved another complete remission.
Haferlach
T
T
II. Medizinische Klinik, Christian-Albrechts-Universität Kiel.
Löffler
H
H
Glass
B
B
Gassmann
W
W
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D014212:Tretinoin / Q000008:administration & dosage
D003561:Cytarabine; D014212:Tretinoin; D015474:Isotretinoin; D003630:Daunorubicin