title: Short course ciprofloxacin therapy for enteric fever.
abstract: A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treatment of enteric fever in 21 hospitalized patients with S.typhi (18) and S.paratyphi A(3). Median time for fever response was 3 days. All isolates were susceptible to ciprofloxacin (MIC 0.0078-0.062 mcgm/ml). The mean serum peak and trough levels were 5.4 and 1.6 mcgm/ml respectively. Stool cultures were free of Salmonellae on follow up (11-24 weeks). Two developed recurrence of paratyphoid fever, 17 days and 4 months after therapy.
authors.affiliation: Department of Medicine, Christian Medical College and Hospital, Vellore, India.
authors.forename: D
authors.initials: D
authors.lastname: Mathai
authors.forename: G C
authors.initials: GC
authors.lastname: Kudva
authors.forename: J S
authors.initials: JS
authors.lastname: Keystone
authors.forename: P E
authors.initials: PE
authors.lastname: Kozarsky
authors.forename: M V
authors.initials: MV
authors.lastname: Jesudason
authors.forename: M K
authors.initials: MK
authors.lastname: Lalitha
authors.forename: A
authors.initials: A
authors.lastname: Kaur
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: John
authors.forename: B M
authors.initials: BM
authors.lastname: Pulimood
mesh_terms: D000328:Adult; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D010284:Paratyphoid Fever / Q000188:drug therapy*; D012008:Recurrence; D012482:Salmonella paratyphi A / Q000302:isolation & purification*; D013997:Time Factors; D014435:Typhoid Fever / Q000188:drug therapy*
chemical_list: D002939:Ciprofloxacin