Emergence of leprosy in a patient with mycosis fungoides.
A patient with mycosis fungoides that had progressed to tumor stage responded to chemotherapy and electron beam treatment, but 6 years later a peripheral neuropathy, extensive plaques, erythroderma, and enlarged pinnae containing acid-fast organisms developed while he was being treated with photopheresis. The skin lesions cleared with administration of rifampin and dapsone, but a reversal reaction biopsy specimen showed features of both mycosis fungoides and leprosy. This case raises the question of whether there may be an association between mycosis fungoides and leprosy.
Grossman
D
D
Department of Dermatology, Baylor College of Medicine, Houston, TX 77030.
Rapini
R P
RP
Osborne
B
B
Duvic
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003622:Dapsone / Q000627:therapeutic use; D006801:Humans; D015440:Leprosy, Lepromatous / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D017893:Photopheresis; D012293:Rifampin / Q000627:therapeutic use; D017192:Skin Diseases, Bacterial / Q000150:complications* / Q000188:drug therapy; D012878:Skin Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy
D003622:Dapsone; D012293:Rifampin