[Electrophysiological properties of the transplanted heart. Clinical applications].
With the improvement in the results of cardiac transplantation, more and more cardiologists are called on to follow up cardiac transplant patients. Cardiological follow-up requires a knowledge of the electrocardiographic and electrophysiological features of the transplanted heart after surgery and the suppression of autonomic innervation. The transplanted heart ECG is characterised by the presence of 2 P waves of different morphology and frequency (from the native and transplanted atria), an acceleration of the sinus rhythm, clockwise rotation of the longitudinal axis, right bundle branch block and ST-T segment changes. The increase in heart rate during exercise is catecholamine-dependent, more progressive and less important than in normal subjects, as is the deceleration of the cardiac rhythm when exercise is stopped. The observation of early sinus node dysfunction is not rare (6.6%) and though usually asymptomatic and transient, implantation of a pacemaker is commonly proposed with different modes of stimulation (VVI, VVIR, AAIR, AAT). The authors have observed changes in the electrophysiological properties of experimental transplanted hearts during acute rejection. The most important of these were in the conduction of the activation within the atrium and in the atrioventricular node, and a reduction in the amplitude of the ventricular potential. The recording of these changes in humans by a non-invasive method could help early diagnosis of acute rejection and limit the number of endomyocardial biopsies. Of the non-invasive techniques under assessment, signal-averaged electrocardiography (temporal and/or frequency analysis) seems to be the most promising.
Babuty
D
D
Service de cardiologie B, hôpital Trousseau, Tours.
Neville
P
P
Aupart
M
M
Rouchet
S
S
Marchand
M
M
Fauchier
J P
JP
Cosnay
P
P
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D002395:Catecholamines / Q000494:pharmacology; D003714:Denervation; D004562:Electrocardiography; D006084:Graft Rejection / Q000175:diagnosis*; D006339:Heart Rate / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D013552:Swine
D002395:Catecholamines
Propriétés électrophysiologiques du coeur transplanté. Applications cliniques.