Disturbance of neuroendocrine regulation of sexual behavior of male rats with streptozotocin diabetes.
Sexual behavior is a constituent of the reproductive function of the organism. In sexually mature individuals the synchronization of the level of sexual activity with the reaction of the hypothalamo-hypophyseo-gonadal system to the relevant environmental stimuli is a necessary condition for the preservation of the species. In this context, the study of the neuroendocrine mechanisms shaping a specific level of activity of sexual behavior is an important problem for investigators. The dependence of the level of sexual activity on the integrity of certain CNS structures (first of all, the olfactory bulbs, amygdala, hypothalamus, and hypophysis) has been established. It has been demonstrated that label sex steroids accumulate selectively, and the regulation of the function of the gonads on the negative feedback principle is also accomplished in these regions precisely. In addition to the participation of the sex steroids in the formation of a specific level of sexual activity, an important role has been established at the present time for luliberin (LHRH) producing system and the neurotransmitters. The stability of the functioning of the reproductive system depends on a multiplicity of factors of the internal and external milieu. Serious disturbances in its function are associated with the alteration in carbohydrate homeostasis underlying a disease such as diabetes mellitus. This is manifested in a reduction in the weight of the accessory sex glands, steroidogenic activity and spermatogenesis, in a change in the secretion of gonadotropins, as well as in a diminution of fertility and sexual behavior.(ABSTRACT TRUNCATED AT 250 WORDS)
El'tseva
T V
TV
Laboratory of Endocrine System Physiology of the Endocrinological Scientific Center, Russian Academy of Medical Sciences, Moscow.
Adamskaya
E I
EI
Peryshkova
T A
TA
Babichev
V N
VN
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology* / Q000523:psychology; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000097:blood; D007328:Insulin / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008473:Median Eminence / Q000502:physiology; D009490:Neurosecretory Systems / Q000503:physiopathology*; D011301:Preoptic Area / Q000502:physiology; D011388:Prolactin / Q000097:blood; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000502:physiology*
D012739:Gonadal Steroid Hormones; D007328:Insulin; D011956:Receptors, Cell Surface; D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone