Two new modified trichothecenes from Fusarium sporotrichioides.
Two new modified trichothecenes, 2-deoxy-11-epi-3 alpha-hydroxysambucoin [1] and 2-deoxy-11-epi-12-acetyl-3 alpha-hydroxysambucoin [2], were isolated from Fusarium sporotrichioides culture. This is the first report of modified trichothecenes where the two six-membered rings are cis-fused. Structures were elucidated using gc-ms, nmr, X-ray crystallography, and other spectroscopic techniques. Compounds 1 and 2 were screened for relative cytotoxicity in cultured baby hamster kidney (BHK-21) cells and found to be non-toxic.
Fort
D M
DM
Department of Chemistry, University of Missouri, Columbia 65211.
Barnes
C L
CL
Tempesta
M S
MS
Casper
H H
HH
Bekele
E
E
Rottinghaus
A A
AA
Rottinghaus
G E
GE
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000302:isolation & purification / Q000633:toxicity; D005670:Fusarium / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007668:Kidney / Q000166:cytology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D014255:Trichothecenes / Q000302:isolation & purification* / Q000633:toxicity; D014908:Triticum / Q000382:microbiology
D003603:Cytotoxins; D014255:Trichothecenes