[Intrathymic regulation of proliferation of medullary thymocytes in CBA mice].
The action of non-peptide mitogenic factor (NMF) on the following thymocytes populations: common cortisone-resistant (CR); cortisone-resistant cells without macrophages (CR-M) and mature (PNP-) thymocytes was studied. It has been shown, that NMF shifts the catabolism of (8-(14) C) AMP towards hypoxanthine accumulation as well as stimulates the (2(-14) C) Thd incorporation in DNA of thymocyte populations to an increasing degree when comparing CR with PNA- cells. The action of NMF is not mediated by macrophages. It has been concluded that mature PNP- population is the target for NMF.
Bezvershenko
I A
IA
Selishcheva
M Iu
MIu
Premislov
V Kh
VKh
Boĭko
M G
MG
D000249:Adenosine Monophosphate / Q000378:metabolism; D000818:Animals; D001685:Biological Factors / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D003348:Cortisone / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D004351:Drug Resistance; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology*
D001685:Biological Factors; D007042:Hypoxanthines; D008934:Mitogens; D019271:Hypoxanthine; D000249:Adenosine Monophosphate; D004247:DNA; D003348:Cortisone; D013936:Thymidine
Vnutrishn'otymichna rehuliatsiia proliferatsiï meduliarovykh tymotsytiv mysheĭ liniï CBA.