[N-demethylation and denitrosation activity of the rat liver, thymus lymphocytes and spleen after exposure to simazine and sodium nitrite].
Simazine and NaNO2 have been studied for their effect on cytochrome P-450-binding N-demethylation and denitrosation activity in the rat liver and lymphocytes in the subchronic (two-month-long) experiment. N-demethylation in lymphocytes of the thymus and spleen was higher than in the liver; denitrosation in the lymphocytes was not observed. Effects of simazine and NaNO2 being injected separately in most of cases have different directions. Combined injection of these substances exceeded the total effect.
Snoz
S V
SV
Dmitrenko
N P
NP
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008745:Methylation; D015538:Nitrosation; D009928:Organ Specificity / Q000502:physiology; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D012839:Simazine / Q000494:pharmacology*; D012977:Sodium Nitrite / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D003577:Cytochrome P-450 Enzyme System; D012977:Sodium Nitrite; D012839:Simazine
N-demetiliruiushchaia i denitroziruiushchaia aktivnost' pecheni, limfotsitov timusa i selezenki krys pri vozdeĭstvii simazina i nitrita natriia.