Cytomegalovirus polyradiculopathy caused by a ganciclovir-resistant strain.
Polyradiculopathy caused by cytomegalovirus (CMV) is a rare but serious neurological disorder that occurs late in the course of HIV-1 infection and is potentially treatable with antimicrobial agents active against CMV. We describe a patient with CMV infection caused by a strain that was resistant to ganciclovir. This case demonstrates one potential mechanism of therapeutic failure and illustrates the potential pathogenicity of strains that are resistant to antiviral drugs.
Tokumoto
J I
JI
Division of Infectious Disease, University of California, San Francisco 94143.
Hollander
H
H
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D003587:Cytomegalovirus / Q000187:drug effects; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D017726:Cytomegalovirus Retinitis / Q000150:complications / Q000188:drug therapy; D004352:Drug Resistance, Microbial; D015774:Ganciclovir / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D008297:Male; D011128:Polyradiculopathy / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology
D015774:Ganciclovir