title: Identification of apparent dual ANCA specificities in a subset of patients with systemic vasculitis and crescentic glomerulonephritis.
abstract: 23% of a random selection of ANCA (+) patients had dual, non-cross reactive autoantibody specificities. We found no clinical difference in such patients as compared to those having a single antibody. A second group of ANCA (+) patients had neither anti-MPO nor anti-PR3 autoantibody specificity. These findings suggest that multiple, coincident ANCA specificities occur more commonly than previously reported, and that additional, unidentified ANCA specificities are present in some patients.
authors.affiliation: Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242.
authors.forename: P
authors.initials: P
authors.lastname: Teeraratkul
authors.forename: J A
authors.initials: JA
authors.lastname: Thorson
authors.forename: J D
authors.initials: JD
authors.lastname: Kemp
authors.forename: J A
authors.initials: JA
authors.lastname: Goeken
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D053146:Myeloblastin; D009195:Peroxidase / Q000276:immunology; D012697:Serine Endopeptidases / Q000276:immunology; D014657:Vasculitis / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin