cDNA cloning of serine/threonine phosphatase catalytic subunits and reversion of the malignant phenotype to the normal phenotype by okadaic acid, a protein phosphatase inhibitor.
Nagao
M
M
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.
Shima
H
H
Sasaki
K
K
Ishizaka
Y
Y
Nakayasu
M
M
Sugimura
T
T
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular / Q000379:methods; D018076:DNA, Complementary / Q000378:metabolism*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D015870:Gene Expression; D015723:Gene Library; D008099:Liver / Q000201:enzymology; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D019319:Okadaic Acid; D009857:Oncogenes; D010641:Phenotype; D010749:Phosphoprotein Phosphatases / Q000096:biosynthesis*; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013737:Testis / Q000201:enzymology; D014158:Transcription, Genetic
D016588:Anticarcinogenic Agents; D018076:DNA, Complementary; D004988:Ethers, Cyclic; D046911:Macromolecular Substances; D012333:RNA, Messenger; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases; D017027:Protein Tyrosine Phosphatases