title: Recombinant interferon-alpha efficacy in relapsed adult nephroblastoma: a case report.
abstract: We report on a 37-year-old woman with progressive lung and pleural metastases from a right nephroblastoma, who achieved partial remission with recombinant interferon-alpha. The drug was given subcutaneously at a dose of 5 mu. 3 times per week. The response was documented after 3 months of treatment and was maintained for at least 9 months. Although such a response has not been reported in the literature, this case suggests promising activity of recombinant interferon-alpha in relapsed nephroblastoma.
authors.affiliation: Department of Medicine, Institut Gustave-Roussy, Villejuif, France.
authors.forename: J
authors.initials: J
authors.lastname: Kattan
authors.forename: J P
authors.initials: JP
authors.lastname: Droz
authors.forename: S
authors.initials: S
authors.lastname: Culine
authors.forename: B
authors.initials: B
authors.lastname: Escudier
authors.forename: C
authors.initials: C
authors.lastname: Beaumont-Raymond
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010997:Pleural Neoplasms / Q000556:secondary / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction; D009396:Wilms Tumor / Q000556:secondary / Q000628:therapy*
chemical_list: D016898:Interferon-alpha; D011994:Recombinant Proteins