title: Response of liver microsomal mixed-function oxidases to dietary linoleic acid levels in rats.
abstract: Responses of the activities of liver microsomal mixed-function oxidases (MFOs) induced by phenobarbital (PB) to dietary linoleic acid (LA) levels were investigated in rats. Diets varied in LA content (0, 1.8, 4.1, 7.0, or 13.8 energy%) were fed to rats for 16 days. The activities of MFOs did not change significantly with increasing the dietary LA level, where they reached a plateau even at 1.8 energy %, although the fatty acid composition of liver microsomal lipids reflected well that of dietary lipids. Accordingly, 2 energy % of LA as essential fatty acid seemed to be sufficient to supply the dietary requirement as assessed by the activities of PB-induced MFOs.
authors.affiliation: Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism / Q000648:ultrastructure; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D008041:Linoleic Acids; D008563:Membrane Lipids; D019787:Linoleic Acid; D006899:Mixed Function Oxygenases; D010634:Phenobarbital