title: Granulocytic sarcoma of the larynx preceding chronic myeloid leukemia.
abstract: The authors report one case of granulocytic sarcoma infiltrating the larynx and cervical lymph nodes in a 50-year-old smoking patient. At the time of diagnosis there was no clinical and laboratory evidence of acute myeloid leukemia or chronic myeloproliferative disease. Four months after diagnosis, bone marrow morphology was consistent with chronic myeloid leukemia, accelerated phase. Cytogenetic abnormalities (Ph 1 chromosome, t(1; 12) (p36; p13), and trisomy of chromosome 20) were also found in hemopoetic cells. Granulocytic sarcoma preceding installation of chronic myeloid leukemia, as described here, seems to be a rare clinical event.
authors.affiliation: Department of Pathology, Faculty of Medicine, State University of Campinas (UNICAMP), São Paulo-Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Vassallo
authors.forename: A M
authors.initials: AM
authors.lastname: Altemani
authors.forename: I A
authors.initials: IA
authors.lastname: Cardinalli
authors.forename: A N
authors.initials: AN
authors.lastname: Crespo
authors.forename: C S
authors.initials: CS
authors.lastname: Lima
authors.forename: K A
authors.initials: KA
authors.lastname: Eid
authors.forename: C A
authors.initials: CA
authors.lastname: Souza
mesh_terms: D006801:Humans; D007830:Larynx / Q000473:pathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009333:Neck