[Reduction of cytochrome p-450 content and activity by porphyrins after damage to the microsomal membrane by tetrachloromethane].
Natural porphyrin (hemin and its synthetic analogue--tetraphenylporphyrin with iron TPP-Fe3+) has been studied for its effect on activity of monooxygenase responses and cytochrome P-450 content against a background of introduction of four-chlorine carbon in the in vitro experiments. The reducing effect of hemin and TPP-Fe3+ on cytochrome P-450 and dependent enzymes: N-demethylase, n-hydroxylase and benz(a)pyrene hydroxylase has been noticed; the synthetic analogue of heme was more efficient.
Ershova
O N
ON
Golovenko
N Ia
NIa
Galkin
B N
BN
Zhilina
Z I
ZI
D000818:Animals; D002251:Carbon Tetrachloride; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects* / Q000378:metabolism; D006427:Hemin / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology; D008665:Metalloporphyrins / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D051381:Rats
D008665:Metalloporphyrins; C032547:iron tetraphenylporphyrin; D006427:Hemin; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride
Vosstanovlenie porfirinami soderzhaniia i aktivnosti tsitokhroma P-450 posle povrazhdeniia mikrosomal'noĭ membrany tetrakhlormetanom.