1 alpha-hydroxyvitamin D3 inhibits type II collagen-induced arthritis in rats.
The effects of 1 alpha-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on Type II collagen-induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1 alpha-hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti-Type II collagen antibodies was decreased in the 1 alpha-hydroxyvitamin D3 treated-group. In contrast, 24,25-dihydroxyvitamin D3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1 alpha-hydroxyvitamin D3 on Type II collagen-induced arthritis in rats and indicate that it has an antirheumatic effect.
Tsuji
M
M
Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan.
Fujii
K
K
Nakano
T
T
Nishii
Y
Y
D000818:Animals; D000906:Antibodies / Q000097:blood; D001168:Arthritis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D002356:Cartilage / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D003094:Collagen / Q000276:immunology; D004487:Edema / Q000517:prevention & control; D005260:Female; D005528:Foot; D006097:Granulation Tissue / Q000473:pathology; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007074:Immunoglobulin G / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013583:Synovial Membrane / Q000473:pathology
D000906:Antibodies; D006887:Hydroxycholecalciferols; D007074:Immunoglobulin G; D003094:Collagen; C008088:alfacalcidol