title: Regulation of inspiratory neuromuscular output during synchronized intermittent mechanical ventilation.
abstract: BACKGROUND
  In synchronized intermittent mandatory ventilation, it is generally accepted that the work of the inspiratory muscles is decreased by the ventilator so that their activity can be modulated by the frequency of assisted breaths. We examined the validity of this concept, which recently has been questioned.
  
  
  METHODS
  We studied five patients receiving synchronized intermittent mandatory ventilation because of an acute exacerbation of chronic obstructive pulmonary disease. The level of machine assistance, defined as the percentage of total ventilation delivered by the ventilator, was varied from a high (> 60%) to a medium (20-50%) and to the lowest tolerated value (0% in four patients). Esophageal pressure, air flow, and the electromyograms of the diaphragm and sternocleidomastoid muscles were recorded. At each level of machine assistance, distinguishing assisted from spontaneous breaths, the duration of electrical activation, the integrated electromyograms, and the work of breathing were computed.
  
  
  RESULTS
  The durations of electrical activation and the integrated electromyograms of the diaphragm and sternocleidomastoid were similar in successive spontaneous and assisted breaths. At > 60% of machine assistance, the cumulative values per minute of the integrated electromyograms of the diaphragm and sternocleidomastoid and the work of breathing were reduced only by 38, 32, and 44%, respectively, compared with the lowest tolerated level of machine assistance. The durations of electrical activation did not change with increasing level of machine assistance.
  
  
  CONCLUSIONS
  The degree of inspiratory muscle rest achieved by synchronized intermittent mandatory ventilation is not proportional to the level of machine assistance; furthermore, the inspiratory motor output is not regulated breath by breath but rather is constant for a given level of machine assistance.
authors.affiliation: Institut de Physiopathologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Imsand
authors.forename: F
authors.initials: F
authors.lastname: Feihl
authors.forename: C
authors.initials: C
authors.lastname: Perret
authors.forename: J W
authors.initials: JW
authors.lastname: Fitting
mesh_terms: D000368:Aged; D003964:Diaphragm / Q000502:physiology; D004576:Electromyography; D005260:Female; D006801:Humans; D007366:Intercostal Muscles / Q000502:physiology; D008173:Lung Diseases, Obstructive / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010369:Pectoralis Muscles / Q000502:physiology; D012121:Respiration, Artificial / Q000379:methods*; D012132:Respiratory Muscles / Q000502:physiology*; D013997:Time Factors; D014939:Work of Breathing / Q000502:physiology