title: Brachmann-de Lange syndrome with normal IQ.
abstract: The Brachmann-de Lange syndrome is a disorder with a high degree of clinical variability, generally associated with moderate to severe mental retardation. To date, 7 previous cases of Brachmann-de Lange syndrome with normal intelligence (IQ > 70) have been described. We report the eighth case of Brachmann-de Lange syndrome with normal intelligence. In reviewing the literature, consistent clinical manifestations seen in these 8 patients that are of prognostic value are the absence of significant limb anomalies and birth weight > 2,500 g.
authors.affiliation: Department of Medical Genetics, Children's National Medical Center, Washington, DC 20010.
authors.forename: H M
authors.initials: HM
authors.lastname: Saal
authors.forename: C A
authors.initials: CA
authors.lastname: Samango-Sprouse
authors.forename: L A
authors.initials: LA
authors.lastname: Rodnan
authors.forename: K N
authors.initials: KN
authors.lastname: Rosenbaum
authors.forename: D A
authors.initials: DA
authors.lastname: Custer
mesh_terms: D002675:Child, Preschool; D003635:De Lange Syndrome / Q000235:genetics / Q000473:pathology / Q000523:psychology*; D005145:Face / Q000002:abnormalities; D006801:Humans; D007360:Intelligence; D017880:Limb Deformities, Congenital; D008297:Male; D010641:Phenotype