title: Reactive species and their accumulation on radical-damaged proteins.
abstract: Hydroperoxides and catechols are described as novel reactive products of radical attack on proteins. These species, like other components of oxidized and otherwise damaged proteins, may accumulate in some biological systems. We propose that the reactive species may then attack other biomolecules, and constitute both a marker and a mechanism of age-related pathologies.
authors.affiliation: Cell Biology Group, Heart Research Institute, Sydney, NSW, Australia.
authors.forename: R T
authors.initials: RT
authors.lastname: Dean
authors.forename: S
authors.initials: S
authors.lastname: Gieseg
authors.forename: M J
authors.initials: MJ
authors.lastname: Davies
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D015415:Biomarkers; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D005609:Free Radicals; D017382:Reactive Oxygen Species; D004295:Dihydroxyphenylalanine; D006861:Hydrogen Peroxide