Thyroid hormone loss and replacement during resuscitation from cardiac arrest in dogs.
Circulating concentrations of thyroxine (T4), triiodothyronine (T3), and reverse triiodothyronine (rT3) were followed in dogs subjected to 9 min of normothermic ventricular fibrillation. Significant decreases were detected 12 h post-arrest when compared to pre-arrest levels in total T4 (P < 0.0005), free T4 (P < 0.0005), total T3 (P < 0.003), and free T3 (P < 0.003), and levels of reverse T3 were significantly elevated (P = 0.0001). Similar changes occurred with only 30 s of arrest. Post-arrest replacement therapy with 7.5 micrograms/kg per h (Rx-7.5) and 15 micrograms/kg per h (Rx-15) levothyroxine sodium (L-T4) increased total T4, free T4, and total T3 (P < 0.01). Free T3 decreased in the Rx-7.5 group (P < 0.01) and did not fall in the Rx-15 group (P = 0.16). Reverse T3 increased with either treatment (P < 0.005). Both treatment groups had higher levels of all five hormones than non-treated animals (P < 0.001). Neurologic function, assessed with a standardized scoring system, showed significant improvement in the treated groups by 6 h (P < 0.05, compared to non-treated group) and remained significant through 24 h post-arrest (P < 0.05). The documentation of rapid and dramatic changes in thyroid hormones immediately following cardiac arrest and resuscitation indicates a significant acute hypothyroid state that may potentially benefit from replacement therapy.
Facktor
M A
MA
Department of Physiology, University of Michigan Medical School, Ann Arbor 48109.
Mayor
G H
GH
Nachreiner
R F
RF
D'Alecy
L G
LG
D000818:Animals; D016887:Cardiopulmonary Resuscitation; D004285:Dogs; D005067:Euthyroid Sick Syndromes / Q000209:etiology / Q000517:prevention & control; D006323:Heart Arrest / Q000378:metabolism / Q000628:therapy*; D008297:Male; D013963:Thyroid Hormones / Q000378:metabolism*; D013974:Thyroxine / Q000627:therapeutic use*; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000378:metabolism / Q000628:therapy
D013963:Thyroid Hormones; D013974:Thyroxine