[Study on the induction of active immunity in human by injecting human anti-HBs antibodies].
One hundred and three health volunteers were injected with various doses of human anti-HBs (Ab1). The anti-idotypic antibodies (Ab2) and anti-antiidiotypic antibodies (Ab)3 in sera were tested at intervals of 30 days with ELISA. We found that the dynamic changes between Ab2 and Ab3 of immune sera were cyclical by way of their interaction and the Ag-specific Ab3 were the same as Ab1 in specificity. The results reconfirmed that exogenous human anti-HBs could induce active immunity by activation of idiotypic network and regulation in human body suggesting that injection of Ig into body could bring about not only passive immunity but also active immunity.
Jia
W
W
Institute of Photoelectric Technology, Chinese Academy of Sciences.
Mu
J
J
Hu
Q
Q
Zhao
Z
Z
Wang
D
D
Zhao
B
B
Liu
W
W
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000008:administration & dosage*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006801:Humans; D007110:Immunity, Active; D007114:Immunization / Q000379:methods*; D008297:Male; D008875:Middle Aged
D000888:Antibodies, Anti-Idiotypic; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens