Antiulcer and gastroprotective effects of quercetin: a gross and histologic study.
This study was designed to determine the cytoprotective properties of quercetin and the involvement of endogenous prostaglandins in mucosal injury produced by absolute ethanol. Gastric glands were also analyzed histologically. Oral pretreatment with the highest dose of quercetin (200 mg/kg), 120 min before absolute ethanol, was most effective in necrosis prevention. Subcutaneous administration of indomethacin (10 mg/kg) to the animals treated with quercetin (200 mg/kg) partially inhibited gastric protection. All treated groups showed a marked increase in the amount of gastric mucus although this increase was less in animals pretreated with indomethacin. Total proteins and the hexosamine content decreased in the groups receiving indomethacin. The histomorphometric evaluation of the gastric damage confirmed a significant increase in mucus production accompanied by a parallel reduction of gastric lesions with the highest dose of quercetin tested.
Alarcón de la Lastra
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Laboratorio de Farmacodinamia, Facultad de Farmacia, Universidad de Sevilla, España.
Martín
M J
MJ
Motilva
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V
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002229:Carbenoxolone / Q000494:pharmacology; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D006595:Hexosamines / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D006595:Hexosamines; D000431:Ethanol; D011794:Quercetin; D002229:Carbenoxolone; D007213:Indomethacin