[Leu31,Pro34]neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake.
Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu31,Pro34]NPY, a Y1 receptor agonist and NPY 20-36, Y2 receptor agonist. [Leu31,Pro34]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu31,Pro34]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y1, but not the Y2, receptor.
Jewett
D C
DC
Department of Psychology, University of Minnesota, Minneapolis.
Cleary
J
J
Schaal
D W
DW
Thompson
T
T
Levine
A S
AS
D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D009478:Neuropeptide Y / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009478:Neuropeptide Y; D010446:Peptide Fragments; C062314:neuropeptide Y (20-36); C062259:neuropeptide Y, Leu(31)-Pro(34)-