[The bioavailability of transdermal therapeutic system of timolol].
A matrix-type transdermal therapeutic system of timolol (TTS-timolol) was well prepared. The patch consisted of backing membrane layer, timolol reservoir layer, pressure sensitive adhesive layer and protective layer. A sensitive and reliable HPLC-UV method for the determination of plasma level of timolol in healthy volunteers was developed. Effective therapeutic plasma level of timolol (4 ng/ml) was attained 4 h after application of the timolol patches and was maintained within 32 h while the patch was removed at 24 h. The pharmacokinetic behavior of this transdermal therapeutic system (TTS)-timolol in human showed zero order absorption and well fitted to a one compartment model. The pharmacokinetic parameters are: Tmax = 18.8 h; Cmax = 11.2 ng/ml; AUC = 265.7 ng/ml.h; Vss = 120.0 L; K = 0.084 h-1. In comparison with the results of oral administration of timolol tablets, TTS-timolol possesses some advantages: stable plasma level, long effective time and convenient administration.
Ji
X F
XF
Department of Pharmaceutics, China Pharmaceutical University, Nanjing.
Ping
Q N
QN
Liu
G J
GJ
Yu
S T
ST
D000279:Administration, Cutaneous; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D016503:Drug Delivery Systems; D006801:Humans; D013999:Timolol / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013999:Timolol