A simplified method for the preparation of succinimidyl carbonate polyethylene glycol for coupling to proteins.
An improved method for the activation of polyethylene glycol with commercially available succinimidyl carbonate is described. The activated polyethylene glycol was coupled to proteins in high yield.
Miron
T
T
Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel.
Wilchek
M
M
D002254:Carbonates / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*
D002254:Carbonates; D011506:Proteins; D013388:Succinimides; C085786:succinimidyl carbonate; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol