Comparative efficacy of amphotericin B, clotrimazole and itraconazole against Aspergillus spp. An in vitro study.
The susceptibilities of two isolates of Aspergillus flavus, one from a human case of recalcitrant mycotic keratitis, and an environmental isolate of A. fumigatus, to itraconazole, clotrimazole and amphotericin B were measured. Observations of macroscopic growth and microscopic evaluations of conidia germination both indicated that the two isolates of A. flavus were markedly more resistant to amphotericin B than to itraconazole and clotrimazole. Itraconazole was more effective than clotrimazole for all isolates. Our in vitro susceptibility results suggest the use of itraconazole should be a primary consideration in the treatment of Aspergillus keratitis.
Hahn
Y H
YH
Department of Ophthalmology, Kosin Medical College, Pusan, Korea.
Ahearn
D G
DG
Wilson
L A
LA
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D003022:Clotrimazole / Q000494:pharmacology; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D003022:Clotrimazole