Left ventricular hypertrophy in post-myocardial infarction left ventricular remodelling and in hypertension; similarities and contrasts.
Hypertensive left ventricular (LV) hypertrophy and post-myocardial infarction (MI) LV remodelling account for most of the clinically significant cases of LV hypertrophy presenting to a clinician. The clinical outcome of patients with concentric LV hypertrophy is known to be poor. However, it has not been widely recognized that post-MI LV remodelling is also dependent on wall stress-driven segmental LV hypertrophy. This review focuses on the similarities shared by these two related processes. The results of large scale clinical trials directed at these two processes is also discussed.
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Cardiovascular Division, Mt. Sinai Medical Center, Miami Beach, FL 33140.
D000818:Animals; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000401:mortality; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality; D011379:Prognosis