All-trans retinoic acid as an alternative to chemotherapy in the treatment of acute promyelocytic leukemia.
A 12-year-old girl with acute promyelocytic leukemia has been treated with conventional chemotherapy. The patient remained in complete remission for a year when the first bone marrow relapse occurred. Since reinduction chemotherapy was rejected by the parents, an alternative treatment with oral all-trans retinoic acid was administered. A second complete remission was achieved within 100 days. After 14 months a second bone marrow relapse occurred. All-trans retinoic acid and the combination with interferon-alpha failed.
Kühne
T
T
University Children's Hospital Basel, Switzerland.
Imbach
P
P
Signer
E
E
Osterwalder
B
B
D002648:Child; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D018168:Receptors, Retinoic Acid / Q000235:genetics; D014212:Tretinoin / Q000627:therapeutic use*
D018168:Receptors, Retinoic Acid; D014212:Tretinoin