Ionic basis for intrinsic 40 Hz neuronal oscillations.
We present a biophysical model of a slowly inactivating potassium ion current IKS, based on recent voltage-clamp data from layer V pyramidal neurons in the cat sensorimotor cortex and show that the interplay between a persistent sodium current INaP and IKS is able to produce intrinsic membrane potential oscillations in the 10- to 50-frequency range. A most notable characteristic of such rhythmicity is what may be termed mixed-mode bursting, where clusters of action potentials alternate in time with epochs of small subthreshold oscillations.
Wang
X J
XJ
D000818:Animals; D002415:Cats; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D009044:Motor Cortex / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology*
D015221:Potassium Channels; D015222:Sodium Channels