title: How antenatal ultrasound diagnosis of congenital malformations has contributed to fetal outcome: a 22-year review.
abstract: We herein reviewed 630 malformed fetuses delivered from 24 weeks of gestation onwards in our institute over the past 22 years. These fetuses were divided into 2 groups: 210 from 1970 to 1982 (group 1) and 420 from 1983 to 1991 (group 2). Twenty-two varieties of congenital malformations were diagnosed antenatally in group 1, whereas 55 additional malformations became diagnosable in group 2. Thirty-four varieties of congenital malformations still remained undiagnosed throughout the 22-year study period. Cases receiving 'fetal therapy' and 'close obstetric care' increased, with statistical significance, from 1.8 to 15.7%, and from 22.9 to 55.7% in groups 1 and 2, respectively. A significant increase was also noted in the survival rate from group 1 (63.3%: 105/166) to group 2 (75.5%: 259/343). This study has revealed that the steady advancement in antenatal diagnosis of congenital malformations, along with great efforts in terms of intensive care, has contributed to improved fetal outcome.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Koyanagi
authors.forename: T
authors.initials: T
authors.lastname: Yoshizato
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Suita
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D001034:Apgar Score; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging* / Q000628:therapy; D005260:Female; D005315:Fetal Diseases / Q000628:therapy; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D011247:Pregnancy; D011256:Pregnancy Outcome; D016216:Ultrasonography, Prenatal