The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships.
Jansen
G
G
Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.
Westerhof
G R
GR
Schornagel
J H
JH
Jackman
A L
AL
Boyle
F T
FT
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists / Q000378:metabolism*; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D051379:Mice; D011799:Quinazolines / Q000737:chemistry / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists; D011799:Quinazolines; D011956:Receptors, Cell Surface; D013940:Thymidylate Synthase