title: [Studies on hypogeusia in hyperemesis gravidarum].
abstract: We measured changes in gustatory sensitivities and gustation threshold levels and those of some trace elements, vitamin E and lipids in the serum of 38 patients suffering from hyperemesis gravidarum, 12 normal pregnant women in the first trimester and 22 healthy non-pregnant women by means of filter discs and an electrogusto meter (EGM) and we obtained the following results. 1. Gustatory sensitivity to sweetness was found to be significantly lowered in the patients with hyperemesis gravidarum when tested with filter discs (p < 0.05). 2. Gustation threshold levels were significantly lowered in the patients with hyperemesis gravidarum and the normal pregnant women tested with the EGM (p < 0.01). 3. There was considerable heterogeusia of women in the patients with hyperemesis gravidarum (p < 0.05). 4. Zn and Mg in serum decreased (p < 0.01), but Cu increased significantly in the patients with hyperemesis gravidarum and the normal pregnant women (p < 0.01). 5. Total cholesterol and phospholipid in serum significantly decreased, but lipid peroxide in serum significantly increased in the patients with hyperemesis gravidarum (p < 0.01). These results suggested that the gustatory test was helpful in investigating hyperemesis gravidarum and that biological defense systems (scavenger systems) to free radicals were damaged in patients with hyperemesis gravidarum.
authors.affiliation: Department of Obstetrics and Gynecology, SDF Central Hospital, Tokyo.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizumoto
authors.forename: T
authors.initials: T
authors.lastname: Okuyama
authors.forename: R
authors.initials: R
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: H
authors.initials: H
authors.lastname: Hiramatsu
authors.forename: M
authors.initials: M
authors.lastname: Horie
authors.forename: H
authors.initials: H
authors.lastname: Masuda
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Saeki
authors.forename: M
authors.initials: M
authors.lastname: Abe
mesh_terms: D000328:Adult; D004408:Dysgeusia / Q000209:etiology*; D005260:Female; D016166:Free Radical Scavengers; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood / Q000150:complications*; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood; D011247:Pregnancy; D013652:Taste Threshold; D014131:Trace Elements / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D008055:Lipids; D014131:Trace Elements; D014810:Vitamin E