Homology of 1-aminocyclopropane-1-carboxylate synthase, 8-amino-7-oxononanoate synthase, 2-amino-6-caprolactam racemase, 2,2-dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and isopenicillin-N-epimerase with aminotransferases.
Profile analysis showed the title enzymes to be homologous with the aminotransferases. 1-Aminocyclopropane-1-carboxylate synthase is closely related to subgroup I of aminotransferases which includes aspartate, alanine, histidinol-phosphate, tyrosine and phenylalanine aminotransferase. 2,2-Dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and 2-amino-6-caprolactam racemase are most similar to subgroup II which comprises aminotransferases with omega-amino acids as substrates. 8-Amino-7-oxononanoate synthase is closely related to both subgroup I and II, and isopenicillin-N-epimerase to subgroup IV with serine and phosphoserine aminotransferase. Aminotransferases and the title enzymes belong to a regio-specific family of evolutionarily related pyridoxal-5'-phosphate-dependent enzymes.
Mehta
P K
PK
Biochemisches Institut, Universität Zürich, Switzerland.
Christen
P
P
D000217:Acyltransferases / Q000737:chemistry*; D000591:Amino Acid Isomerases / Q000737:chemistry*; D001419:Bacteria / Q000201:enzymology; D001426:Bacterial Proteins; D005075:Biological Evolution; D002262:Carboxy-Lyases / Q000737:chemistry*; D019751:Intramolecular Transferases; D007535:Isomerases / Q000737:chemistry*; D008190:Lyases / Q000737:chemistry*; D010944:Plants / Q000201:enzymology; D017386:Sequence Homology, Amino Acid; D000637:Transaminases / Q000737:chemistry*
D001426:Bacterial Proteins; D000217:Acyltransferases; C021929:8-amino-7-oxononanoate synthase; D000637:Transaminases; D008190:Lyases; D002262:Carboxy-Lyases; C063519:2,2-dialkylglycine decarboxylase; C021773:1-aminocyclopropanecarboxylate synthase; D007535:Isomerases; D000591:Amino Acid Isomerases; C036861:aminocaprolactam racemase; C040886:isopenicillin N epimerase; D019751:Intramolecular Transferases; C061049:glutamate-1-semialdehyde 2,1-aminomutase