title: [Reduction of cytochrome p-450 content and activity by porphyrins after damage to the microsomal membrane by tetrachloromethane].
abstract: Natural porphyrin (hemin and its synthetic analogue--tetraphenylporphyrin with iron TPP-Fe3+) has been studied for its effect on activity of monooxygenase responses and cytochrome P-450 content against a background of introduction of four-chlorine carbon in the in vitro experiments. The reducing effect of hemin and TPP-Fe3+ on cytochrome P-450 and dependent enzymes: N-demethylase, n-hydroxylase and benz(a)pyrene hydroxylase has been noticed; the synthetic analogue of heme was more efficient.
authors.forename: O N
authors.initials: ON
authors.lastname: Ershova
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Golovenko
authors.forename: B N
authors.initials: BN
authors.lastname: Galkin
authors.forename: Z I
authors.initials: ZI
authors.lastname: Zhilina
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects* / Q000378:metabolism; D006427:Hemin / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology; D008665:Metalloporphyrins / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D051381:Rats
chemical_list: D008665:Metalloporphyrins; C032547:iron tetraphenylporphyrin; D006427:Hemin; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride
vernacular_title: Vosstanovlenie porfirinami soderzhaniia i aktivnosti tsitokhroma P-450 posle povrazhdeniia mikrosomal'noĭ membrany tetrakhlormetanom.