title: Cement particles inhibit bone growth into titanium chambers implanted in the rabbit.
abstract: Particles of bone cement have been shown previously to stimulate the resorption of bone. The purpose of this study was to determine whether particles of bone cement (BC) have an adverse effect on bone ingrowth. The bone harvest chamber was implanted bilaterally in the proximal tibial metaphysis of 6 mature rabbits. Both the fixed outer cylinder and the inner removable core of the chamber have a transverse 1 mm wide pore providing a continuous canal for tissue ingrowth. After an initial 6-week period for osseointegration of the outer cylinder, the contents of the inner core were harvested repeatedly at 3 weekly intervals. In the first series of rabbits, the carrier solution, 1% sodium hyaluronate (Healon) was implanted first. In subsequent implantations, Healon was mixed with small fabricated particles of BC (averaging 3.54 mm in diameter) to fill the channel of the core. The contralateral chamber was left empty and served as a control. In the second series of rabbits, implantation was carried out sequentially using the same material bilaterally. The sections from the control harvests, and those with Healon alone contained extensive trabecular bone arranged longitudinally in the canal, in a fibrovascular stroma. The sections containing BC particles were infiltrated by foamy, mononuclear and multinuclear histiocytic cells. Less trabecular bone was seen in the sections containing BC particles compared to the control sections or those containing Healon alone. Previous studies have shown that particles of bone cement stimulate bone resorption. In this study, BC particles have also been shown to diminish the formation of new bone.
authors.affiliation: Department of Orthopedics, University Hospital, Lund, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Goodman
authors.forename: P
authors.initials: P
authors.lastname: Aspenberg
authors.forename: J S
authors.initials: JS
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: A
authors.initials: A
authors.lastname: Doshi
authors.forename: D
authors.initials: D
authors.lastname: Regula
authors.forename: J
authors.initials: J
authors.lastname: Emmanual
authors.forename: L
authors.initials: L
authors.lastname: Lidgren
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D005260:Female; D006652:Histological Techniques; D006820:Hyaluronic Acid / Q000494:pharmacology; D008297:Male; D008768:Methylmethacrylates / Q000494:pharmacology*; D016348:Osseointegration / Q000187:drug effects*; D011817:Rabbits
chemical_list: D008768:Methylmethacrylates; D006820:Hyaluronic Acid