title: Behavioral analysis of asymmetries induced by unilateral 6-OHDA injections into the substantia nigra.
abstract: The intent of this study was to perform a detailed analysis of behavioral asymmetries (turning behavior) exhibited by animals which had sustained a unilateral lesion of the substantia nigra (SN). Rats were tested for behavior asymmetries over 16 days, once before, and 7 times after 6-OHDA had been injected into one SN. On the basis of the number of narrow diameter ipsiversive half turns produced during testing, they were then assigned to one of three groups: (a) those which showed an initial asymmetry from which they recovered, (b) those which were asymmetrical throughout testing, and (c) those in which the asymmetry only emerged during the testing period. We examined several different aspects of turning behavior. Recovery from asymmetry was associated with an increase in the number of contraversive, as well as a decrease in the number of ipsiversive narrow-angle turns. The average diameter of these ipsiversive turns also increased. Animals which recovered showed a contraversive asymmetry for wide-diameter turns which increased during testing. Narrow-diameter contraversive turns decreased during testing in the two nonrecovery groups. Both nonrecovery groups showed a contraversive asymmetry for wide-diameter turns. Asymmetry was attributable to a tendency to circle and move ipsiversively in the two nonrecovery groups, whereas it was due to circling behavior in animals which showed recovery. Additionally, more cells, labeled by HRP injected into the ipsilateral caudate putamen, were found in the damaged SN of animals which recovered.
authors.affiliation: University of Düsseldorf, Institute of Physiological Psychology I, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Morgan
authors.forename: G
authors.initials: G
authors.lastname: Nomikos
authors.forename: J P
authors.initials: JP
authors.lastname: Huston
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002421:Caudate Nucleus / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects*
chemical_list: D016627:Oxidopamine; D004298:Dopamine