title: Fungal metabolites. IX. Synthesis of a membrane-modifying peptide, hypelcin A-III, from Hypocrea peltata.
abstract: A membrane-modifying peptide antibiotic having uncoupling activity on rat liver mitochondria, hypelcin A-III, has been synthesized by assembling five peptide fragments via the N,N'-dicyclohexylcarbodiimide method. The synthesized hypelcin A-III was identical with the natural product.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuura
authors.forename: A
authors.initials: A
authors.lastname: Yesilada
authors.forename: A
authors.initials: A
authors.lastname: Iida
authors.forename: Y
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: T
authors.initials: T
authors.lastname: Fujita
mesh_terms: D000408:Alamethicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000595:Amino Acid Sequence; D006999:Hypocreales / Q000378:metabolism*; D008969:Molecular Sequence Data
chemical_list: D000408:Alamethicin; C025478:hypelcin A