title: Integrated approach to the management of patients with advanced germ cell tumors of the testis.
abstract: Between 1985 and 1991, 63 patients with disseminated germ cell tumors of the testis were treated with initial cisplatin based combination chemotherapy. Complete response was seen in 38% of patients. Adjunctive surgical resection of residual disease was carried out in 26 patients (41%), including the use of intraoperative radiation therapy in two patients with seminoma. Furthermore, two other patients with seminoma and residual mass underwent retroperitoneal irradiation. Salvage chemotherapy was administered to five patients with progressive disease, and only one of these could be salvaged with adjunctive surgery. A disease-free state was achieved in 75% of patients at a mean follow-up period of 30 months.
authors.affiliation: Department of Genitourinary Surgery, Cancer Institute, Adyar, Madras, India.
authors.forename: R
authors.initials: R
authors.lastname: Ravi
authors.forename: R R
authors.initials: RR
authors.lastname: Rao
authors.forename: V
authors.initials: V
authors.lastname: Shanta
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018237:Germinoma / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome