title: Analysis of human herpes virus-6 genomes in lymphoid malignancy in Japan.
abstract: Ninety cases of malignant lymphoma and 56 cases of reactive lymphadenopathy were studied using Southern blot analysis and the polymerase chain reaction to identify human herpes virus-6 (HHV-6) DNA. This was detected in cases of lymphoid malignancy at a rate which ranged from 50.0% to 68.8%. There were no differences in rates for different types of lymphoid malignancies. Herpes virus-6 DNA was detected by PCR in lymphoid malignancies less frequently than in reactive lymphadenopathies. It was not detected in lymphoid malignancies using Southern blotting. These results suggest that HHV-6 DNA was not related to lymphoid malignancy and was only a latent infection of non-neoplastic cells in tumour tissue.
authors.affiliation: First Department of Pathology, School of Medicine, Fukuoka University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sumiyoshi
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: M
authors.initials: M
authors.lastname: Takeshita
authors.forename: Y
authors.initials: Y
authors.lastname: Eizuru
authors.forename: Y
authors.initials: Y
authors.lastname: Minamishima
mesh_terms: D001483:Base Sequence; D015139:Blotting, Southern; D017931:DNA Primers; D004279:DNA, Viral / Q000032:analysis*; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology; D008223:Lymphoma / Q000382:microbiology*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D004279:DNA, Viral