[Upper digestive hemorrhage. Comparison of terlipressin and octreotide].
The efficacy and tolerability of both Terlipressin and Octreotide in the treatment of upper digestive haemorrhage (oesophagus, stomach and duodenum) have been compared, at random, on 30 adult patients. Terlipressin dosage was 2 mg/4 hours i.v. during the first 24 hours, 2 mg/6 hours during the following 24 hours. Octreotide dosage was 50 micrograms i.v. and infusional therapy, 25 micrograms/hours, followed. Haemostasis was obtained in 100% of patients treated with Terlipressin and in 73% of patients treated with Octreotide. Rebleeding occurred in 3 patients treated with Terlipressin and 4 patients treated with Octreotide. Side effects occurred in 4 patients treated with Terlipressin and 8 patients treated with Octreotide. Terlipressin proved to have a better efficacy in comparison with Octreotide, and had less side effects.
Campisi
C
C
Dipartimento di Chirurgia d'Urgenza, Ospedale S. Martino, Università degli Studi di Genova.
Padula
P
P
Peressini
A
A
Boccardo
F
F
Biraghi
M
M
Casaccia
M
M
D000328:Adult; D000368:Aged; D004378:Duodenal Diseases / Q000188:drug therapy*; D004935:Esophageal Diseases / Q000188:drug therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D006801:Humans; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D013272:Stomach Diseases / Q000188:drug therapy*; D000077585:Terlipressin
D008236:Lypressin; D000077585:Terlipressin; D015282:Octreotide
Emorragie digestive alte. Confronto fra Terlipressina e Octreotide.