Growth hormone response to intravenous clonidine in social phobia: comparison to patients with panic disorder and healthy volunteers.
The growth hormone (GH) response to intravenous administration of clonidine hydrochloride (2 micrograms/kg) was assessed in 16 patients with DSM-III-R social phobia, 13 patients with DSM-III-R panic disorder, and 31 healthy controls. Compared to the healthy volunteers, both social phobic and panic-disorder patients had significantly blunted GH increments after clonidine. The social phobic patients demonstrated a similar degree of GH "blunting" to clonidine as did the patients with panic disorder.
Tancer
M E
ME
Section on Anxiety and Affective Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.
Stein
M B
MB
Uhde
T W
TW
D000328:Adult; D003000:Clonidine; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D010698:Phobic Disorders / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D012016:Reference Values
D013006:Growth Hormone; D003000:Clonidine