title: Neurosyphilis presenting with optic neuropathy. Report of a case and review.
abstract: A patient with neurosyphilis, presenting with severe ocular impairment due to optic neuropathy, is described. In such a case, a low index of clinical suspicion and improper use of syphilitic serologic tests may delay diagnosis. However, specific tests of serum and cerebrospinal fluid are mandatory for the diagnosis. Treatment evaluation necessitates the follow-up of serology and cerebrospinal fluid cell count. Recent changes of therapy recommendations in subjects with neurosyphilis and in those syphilitic patients co-infected with HIV are mentioned.
authors.affiliation: Department of Internal Medicine, Universitair Ziekenhuis, Gent.
authors.forename: E
authors.initials: E
authors.lastname: Pelfrene
authors.forename: W
authors.initials: W
authors.lastname: Michielsen
authors.forename: D
authors.initials: D
authors.lastname: Voet
authors.forename: M
authors.initials: M
authors.lastname: Hanssens
authors.forename: M
authors.initials: M
authors.lastname: Afschrift
authors.forename: J J
authors.initials: JJ
authors.lastname: De Laey
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009494:Neurosyphilis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D009896:Optic Atrophy / Q000209:etiology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D010406:Penicillins / Q000008:administration & dosage; D013588:Syphilis Serodiagnosis
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins