title: Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease.
abstract: Among 23 patients with Alzheimer's disease, 11 (48%) exhibited cortisol hypersecretion (> or = 11.8 micrograms/dl) and nine (39%) displayed cortisol nonsuppression on the dexamethasone suppression test. Only four patients exhibited both neuroendocrine abnormalities, demonstrating a lack of association between these two neuroendocrine disturbances of over 50%. Twenty-two of the 23 patients were studied for 4 1/2 years, and 14 died during that period. Six of the eight surviving patients exhibited cortisol hypersecretion without cortisol nonsuppression.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: A H
authors.initials: AH
authors.lastname: Miller
authors.forename: G
authors.initials: G
authors.lastname: Sastry
authors.forename: A J
authors.initials: AJ
authors.lastname: Speranza
authors.forename: B A
authors.initials: BA
authors.lastname: Lawlor
authors.forename: R C
authors.initials: RC
authors.lastname: Mohs
authors.forename: T M
authors.initials: TM
authors.lastname: Ryan
authors.forename: S M
authors.initials: SM
authors.lastname: Gabriel
authors.forename: M
authors.initials: M
authors.lastname: Serby
authors.forename: J
authors.initials: J
authors.lastname: Schmeidler
authors.forename: K L
authors.initials: KL
authors.lastname: Davis
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis*; D003907:Dexamethasone; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone