Facilitation of cocaine kindling by glucocorticoids in rats.
We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.
Kling
M A
MA
Clinical Neuroendocrinology Branch, NIMH, Bethesda, MD 20892.
Smith
M A
MA
Glowa
J R
JR
Pluznik
D
D
Demas
J
J
DeBellis
M D
MD
Gold
P W
PW
Schulkin
J
J
D000818:Animals; D003042:Cocaine / Q000633:toxicity*; D003345:Corticosterone / Q000633:toxicity*; D003907:Dexamethasone / Q000633:toxicity*; D004357:Drug Synergism; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013239:Stereotyped Behavior / Q000187:drug effects
D003907:Dexamethasone; D003042:Cocaine; D003345:Corticosterone