title: Fulminant hepatic failure after Lepiota mushroom poisoning.
abstract: We present ten patients who suffered from a cyclopeptide syndrome from two different foci, one caused by Lepiota helveola (seven cases) and the other by Lepiota brunneoincarnata (three cases). Of the ten victims, five recovered completely after the intestinal stage and the other five developed a phase of visceral involvement with alterations of liver function. In two patients, hepatic function became normal after the 7th day after ingestion. Three patients developed fulminant hepatitis and two of these died of adult respiratory distress syndrome. The fulminant hepatitis patient who later improved developed active chronic hepatitis 1 year later. Finally, five patients developed mixed polyneuropathy. In this paper the indications for orthotopic liver transplant (OLTx) are discussed and the development of late complications such as active chronic hepatitis and mixed polyneuropathy are considered.
authors.affiliation: Department of Surgery, Virgen de la Arrixaca University hospital, Murcia, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Ramirez
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
authors.forename: F
authors.initials: F
authors.lastname: Sanchez Bueno
authors.forename: R
authors.initials: R
authors.lastname: Robles
authors.forename: J A
authors.initials: JA
authors.lastname: Pons
authors.forename: V
authors.initials: V
authors.lastname: Bixquert
authors.forename: S
authors.initials: S
authors.lastname: Nicolas
authors.forename: R
authors.initials: R
authors.lastname: Nuñez
authors.forename: M S
authors.initials: MS
authors.lastname: Alegria
authors.forename: M
authors.initials: M
authors.lastname: Miras
mesh_terms: D000328:Adult; D004196:Disease Outbreaks; D005260:Female; D006501:Hepatic Encephalopathy / Q000150:complications / Q000209:etiology* / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009145:Mushroom Poisoning / Q000150:complications* / Q000453:epidemiology; D009422:Nervous System Diseases / Q000209:etiology