title: Systolic blood pressure during submaximal exercise: an important correlate of cardiovascular disease risk factors in normotensive obese women.
abstract: Body fatness, plasma lipids, lipoproteins, indicators of glucose metabolism, and resting as well as submaximal treadmill exercise systolic blood pressures (BPs) were measured in a sample of 25 normotensive obese premenopausal women. No association was observed between body fatness, risk factors for cardiovascular disease, and resting BP. However, body fatness and plasma cholesterol, low-density lipoprotein cholesterol (LDL-CHOL), LDL apolipoprotein B (apo B), and apo B concentrations, as well as the high-density lipoprotein cholesterol to cholesterol (HDL-CHOL/CHOL) ratio, showed significant correlations with systolic BP measured during submaximal exercise. In addition, fasting plasma insulin concentrations and the glucose and insulin areas under the oral glucose tolerance test (OGTT) curve were both significantly associated with systolic BP during submaximal exercise. Partial correlation analyses revealed that the associations between submaximal exercise systolic BP and plasma apo B and LDL apo B levels were in part independent from the level of obesity. These results indicate that plasma concentrations of lipoproteins and insulin are important correlates of the systolic BP during submaximal exercise in obese premenopausal women. Further analyses performed on two subgroups indicated that women with high exercise systolic BP values exhibited significant differences in their metabolic profile in comparison to women with low BP during exercise. These results suggest that the absolute systolic BP recorded during submaximal exercise may be useful in the early detection of individuals at risk for the development of cardiovascular disease in resting normotensive obese women.
authors.affiliation: Physical Activity Sciences Laboratory, Laval University Medical Research Center, Ste-Foy, Quebec, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Prud'homme
authors.forename: J P
authors.initials: JP
authors.lastname: Després
authors.forename: J F
authors.initials: JF
authors.lastname: Landry
authors.forename: S
authors.initials: S
authors.lastname: Moorjani
authors.forename: P J
authors.initials: PJ
authors.lastname: Lupien
authors.forename: A
authors.initials: A
authors.lastname: Tremblay
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000328:Adult; D001055:Apolipoproteins B / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology*; D001824:Body Constitution; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D008078:Cholesterol, LDL / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors; D013599:Systole / Q000502:physiology
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D005947:Glucose