title: Type IV renal tubular acidosis and spironolactone therapy in the elderly.
abstract: Spironolactone therapy is a well-known cause of hyperkalaemia, but in susceptible patient, it may also be associated with metabolic acidosis. We report a case of severe renal tubular acidosis (Type IV) with life-threatening hyperkalaemia caused by spironolactone, and discuss the mechanisms by which this may occur.
authors.affiliation: Geriatric Medicine Unit, University of Edinburgh, City Hospital, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: O'Connell
authors.forename: N R
authors.initials: NR
authors.lastname: Colledge
mesh_terms: D000141:Acidosis, Renal Tubular / Q000139:chemically induced*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D013148:Spironolactone / Q000009:adverse effects*
chemical_list: D013148:Spironolactone