Maudsley rat strains, selected for differences in emotional responses, differ in behavioral response to clonidine and in [125I]clonidine binding in the locus coeruleus.
Maudsley rats, selectively inbred for emotionality for over sixty generations, differ in reactivity to stress, both at the peripheral level and within the central noradrenergic system. The present experiments examine to what extent these central differences might be due to differences in the inhibitory processes mediated by alpha 2 autoreceptors within the locus coeruleus. Maudsley reactive rats (MRs), the strain which showed a much higher central noradrenergic response to immobilisation stress, required higher doses of the alpha 2 receptor agonist, clonidine, to induce behavioral sedation than the Maudsley non-reactive rats (MNRA). Autoradiographic studies showed a significantly higher level of binding of 125iodeclonidine in the locus coeruleus of the MNRAs compared to the MRs, indicating that the former had more alpha 2 receptors and/or these receptors had a greater affinity for the agonist. Thus autoinhibitory processes within the locus coeruleus are different in the two strains, which could account for the differences in reactivity to stress seen in the biochemical and behavioral studies.
Sara
S J
SJ
Institut des Neurosciences, CNRS Université Pierre & Marie Curie, Paris, France.
Devauges
V
V
Biegon
A
A
D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001931:Brain Mapping; D003000:Clonidine / Q000493:pharmacokinetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects* / Q000502:physiology; D005260:Female; D008125:Locus Coeruleus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications
D018341:Receptors, Adrenergic, alpha-2; D003000:Clonidine; D009638:Norepinephrine