[Acute carbamazepine poisoning treated with plasmapheresis. Description of a clinical case].
A case of severe Carbamazepine poisoning initially misdiagnosed is reported. Treatment consisted in plasmapheresis (3.5 liters exchanged) repeated for 3 consecutive days, in conjunction with activated charcoal and advanced life support. It was obtained a rapid decay in Carbamazepine plasmatic level (with rebound phenomenon only after first treatment day) and a contemporary improvement in clinical conditions. The patient was discharged without complications after 6 days stay in ICU. Taking pharmacokinetic characteristics into account, it is suggested that plasmapheresis may be useful in this kind of poisoning.
Gambi
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U.O. Anestesia e Rianimazione, USL 10/C, Nuovo Ospedale S. Giovanni di Dio, Firenze.
Oggioni
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R
Mangani
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V
Librenti
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M
Manescalchi
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Tulli
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G
D000208:Acute Disease; D000293:Adolescent; D002220:Carbamazepine / Q000506:poisoning*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D011041:Poisoning / Q000503:physiopathology / Q000628:therapy
D002220:Carbamazepine
Intossicazione acuta da carbamazepina trattata con plasmaferesi. Descrizione di un caso clinico.