Primary malignant lymphoma of the uterine cervix: is radiotherapy the best therapeutic choice for stage IE?
The present report describes a 27-year-old woman diagnosed with Ann Arbor stage IE primary malignant lymphoma of the cervix. Radiation therapy was instituted as conventionally advocated at this early stage of the disease. Despite adequate local tumor response, central nervous system metastasis occurred a few months later. She succumbed to her condition 7 months after initial diagnosis. As occult distant foci may not be amenable to detection by available imaging techniques at the time of initial work-up, combination chemotherapy alone or in conjunction with radiation therapy may be the most appropriate first line of therapy in patients with stage IE primary malignant lymphoma of the cervix.
Awwad
J T
JT
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon.
Khalil
A M
AM
Shamseddine
A I
AI
Mufarrij
A A
AA
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D012535:Scalp; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000556:secondary; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone