[A trial of the clinical use of the Russian hypocholesterolemic preparation fenbutol--an analog of probucol].
Phenbutol, a Russian analogue of probucol, was studied by the single blind method by using placebo in 30 patients aged 36 to 65 years whose total serum cholesterol levels were more than 250 mg/dl after a month placebo therapy. The patients were divided into two groups: (1) 15 patients on placebo and (2) 15 patients on phenbutol, 500 mg twice a day for 5 months. Blood lipid parameters were monthly determined. The findings are in agreement with the data on the effects of probucol on lipids and its adverse effects. During the follow-up, phenbutol showed 17%, 14% and 10% decreases in total cholesterol and low density lipoprotein cholesterol and high density lipoprotein cholesterol, respectively, as compared with the baselines. These changes were greater than those in patients on placebo. In the first week of therapy with phenbutol, vomiting, appetite decrease, digestive disturbances were observed in 73% of patients. These adverse reactions did not require its withdrawal. Resting ECG Q-T interval became prolonged in 7 out of 15 patients receiving phenbutol (maximum 500 msec).
Nechaev
A S
AS
Gerasimenko
T I
TI
Gratsianskiĭ
N A
NA
Nikitina
N A
NA
Kliuchnikova
Zh I
ZhI
D000328:Adult; D000368:Aged; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011341:Probucol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016037:Single-Blind Method; D013997:Time Factors
D008055:Lipids; D008074:Lipoproteins; C085805:fenbutol; D011341:Probucol
Opyt klinicheskogo primeneniia otechestvennogo gipokholesterinemicheskogo preparata fenbutola--analoga probukola.