Combination therapy: photochemotherapy; electric current; and ionizing radiation. Different combinations studied in a WiDr human colon adenocarcinoma cell line.
The interactions of pairs of the modalities Photofrin II-sensitized photochemotherapy (PCT), ionizing radiation and an electric current were investigated by the colony formation assay in WiDr cells, a human colon adenocarcinoma cell line. When the cells were treated simultaneously with PCT and an electric current, a slightly synergistic effect was observed at low exposures (surviving fraction approximately 0.1) while a seemingly antagonist effect was found at higher exposures. The same was found to be true for the combinations of PCT plus ionizing radiation and ionizing radiation plus electric current.
Ma
L
L
Department of Biophysics, Institute for Cancer Research, Oslo, Norway.
Iani
V
V
Moan
J
J
D000230:Adenocarcinoma; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D003110:Colonic Neoplasms; D003131:Combined Modality Therapy; D046508:Culture Techniques / Q000295:instrumentation; D017323:Dihematoporphyrin Ether / Q000633:toxicity*; D004558:Electric Stimulation; D004599:Electric Stimulation Therapy; D006801:Humans; D010778:Photochemotherapy; D011878:Radiotherapy; D014407:Tumor Cells, Cultured
D017323:Dihematoporphyrin Ether