title: Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer.
abstract: Serum samples from 82 patients with epithelial ovarian cancer, previously assayed for CA125, were assayed for circulating colony-stimulating factor 1 (CSF-1). An elevated CSF-1 concentration (> 450 U ml-1 or > 5.42 ng ml-1) was significantly associated with a worse survival (P = 0.02). The predictive value of raised CSF-1 levels was retained whether the first available sample for all patients (n = 82) or the first sample at the start of chemotherapy (n = 41) was considered. Mean CSF-1 levels (n = 14) dropped significantly during six courses of platinum-based chemotherapy (P = 0.02). Although an elevated CA125 concentration appeared to be a prognostic indicator in the total population (n = 82), it was not related to prognosis in the group of patients from whom samples had been drawn at the start of chemotherapy. In a Cox proportional hazards model, CSF-1, but not CA125, was significantly associated with outcome following adjustment for stage, grade and degree of surgical clearance.
authors.affiliation: Département de Médecine Oncologique, Institut Curie, France.
authors.forename: S M
authors.initials: SM
authors.lastname: Scholl
authors.forename: C H
authors.initials: CH
authors.lastname: Bascou
authors.forename: V
authors.initials: V
authors.lastname: Mosseri
authors.forename: R
authors.initials: R
authors.lastname: Olivares
authors.forename: H
authors.initials: H
authors.lastname: Magdelenat
authors.forename: T
authors.initials: T
authors.lastname: Dorval
authors.forename: T
authors.initials: T
authors.lastname: Palangié
authors.forename: P
authors.initials: P
authors.lastname: Validire
authors.forename: P
authors.initials: P
authors.lastname: Pouillart
authors.forename: E R
authors.initials: ER
authors.lastname: Stanley
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000401:mortality; D018262:Adenocarcinoma, Clear Cell / Q000097:blood / Q000401:mortality; D002288:Adenocarcinoma, Mucinous / Q000097:blood / Q000401:mortality; D018269:Carcinoma, Endometrioid / Q000097:blood / Q000401:mortality; D018284:Cystadenocarcinoma, Serous / Q000097:blood / Q000401:mortality; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000401:mortality*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D016173:Macrophage Colony-Stimulating Factor