title: Viral protein kinases and protein phosphatases.
abstract: Certain large DNA viruses (e.g. herpesviruses and poxviruses) encode proteins related to cellular protein-serine/threonine kinases, and Hepatitis B virus and vesicular stomatitis virus may encode structurally different protein kinases. Other viruses activate cellular protein kinases, e.g. interferon-induced eukaryotic initiation factor-2 kinase, growth factor-induced kinases and protein kinases that regulate mitosis. Protein phosphatases are encoded by vaccinia virus and bacteriophage lambda and must also play a role in viral infection--as do cellular protein phosphatases. The functions of many of these viral enzymes remain to be determined, but they represent possible new targets for anti-viral therapy.
authors.affiliation: Department of Biochemistry, University of Glasgow, U.K.
authors.forename: D P
authors.initials: DP
authors.lastname: Leader
mesh_terms: D000595:Amino Acid Sequence; D016384:Consensus Sequence; D008969:Molecular Sequence Data; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000502:physiology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000737:chemistry / Q000502:physiology*; D013379:Substrate Specificity; D014780:Viruses / Q000201:enzymology*
chemical_list: D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases