Salivary excretory pattern of testosterone in substitutive therapy with testosterone enanthate.
OBJECTIVE
To determine salivary and serum T levels by an RIA method after a single injection of 250 mg IM of commercially available T enanthate.


METHODS
Research study.


METHODS
Patients attended in a hospital environment.


METHODS
Sixteen men with secondary hypogonadism.


METHODS
Testosterone enanthate was administered, and salivary samples were taken before the injection. Thereafter, these samples were obtained daily until day 7 and then on alternate days until day 28 after injection. Blood samples were taken previously and after the injection (5 samples during the month).


METHODS
Salivary and serum T.


RESULTS
Salivary T levels rose from 3.46 +/- 3.16 to 13.82 +/- 7.78 ng/100 mL (0.12 +/- 0.11 to 0.48 +/- 0.27 nmol/L) within 24 hours and remained in that range until day 7. From day 9, 7.20 +/- 2.88 ng/100 mL (0.25 +/- 0.10 nmol/L), a progressive decrease of these values was observed until day 14: 5.18 +/- 2.88 ng/100 mL (0.18 +/- 0.10 nmol/L). From day 16 until day 28, salivary concentrations returned to hypogonadal levels.


CONCLUSIONS
We conclude that T salivary concentrations may be applied to assess the effectiveness of T substitutive therapy in hypogonadal men and could replace serum in the monitoring of this type of therapy.
Navarro
M A
MA
Hormone Unit (Biochemistry Service), Ciutat Sanitària i Universitària de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Villabona
C M
CM
Blanco
A
A
Gomez
J M
JM
Bonnin
R M
RM
Soler
J
J
D000328:Adult; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D007273:Injections, Intramuscular; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors
D013739:Testosterone; C004648:testosterone enanthate