title: Marked increase in fundic mucosal histidine decarboxylase activity in a patient with H+,K(+)-ATPase antibody-positive autoimmune gastritis.
abstract: A 63-year-old woman was diagnosed as autoimmune gastritis by the presence of serum antibody against alpha-subunit of gastric H+,K(+)-ATPase. The patient did not have pernicious anemia, but showed achlorhydria, marked hypergastrinemia, enterochromaffin-like cell hyperplasia and an extremely high histidine decarboxylase activity in the gastric fundic mucosa. Intragastric acidification by infusion of hydrochloric acid via a nasogastric tube induced a transient reduction of serum gastrin level and fundic mucosal histidine decarboxylase activity. A marked increase in fundic mucosal histidine decarboxylase activity as well as hypergastrinemia appears to be the pathophysiologic response to achlorhydria caused by autoimmunity against gastric H+,K(+)-ATPase.
authors.affiliation: Second Department of Internal Medicine, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Shinomura
authors.forename: Y
authors.initials: Y
authors.lastname: Murayama
authors.forename: I
authors.initials: I
authors.lastname: Imamura
authors.forename: H
authors.initials: H
authors.lastname: Fukui
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Futai
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D000126:Achlorhydria / Q000209:etiology / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000150:complications / Q000201:enzymology* / Q000276:immunology; D004759:Enterochromaffin Cells / Q000473:pathology; D005260:Female; D005748:Gastric Fundus / Q000201:enzymology*; D005753:Gastric Mucosa / Q000201:enzymology*; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000150:complications / Q000201:enzymology* / Q000276:immunology; D006111:Graves Disease / Q000150:complications; D017506:H(+)-K(+)-Exchanging ATPase / Q000276:immunology*; D006640:Histidine Decarboxylase / Q000032:analysis*; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000473:pathology; D011127:Polyps / Q000150:complications; D013274:Stomach Neoplasms / Q000150:complications
chemical_list: D005755:Gastrins; D017506:H(+)-K(+)-Exchanging ATPase; D006640:Histidine Decarboxylase