title: Hereditary papillary renal cell carcinoma.
abstract: We describe a 3 generation family with members affected with papillary renal cell carcinoma, an uncommon histological type of renal cell carcinoma. Multiple tumors of varying size were present in both kidneys of affected family members. The disorder was not linked to polymorphic markers on chromosome 3p and there was no loss of heterozygosity at loci on 3p in renal tumors. The results suggest the presence of a renal cell carcinoma gene not located on 3p that predisposes to renal cell carcinoma with a distinct histological appearance. The inherited disorder in this family appears to be different from recognized hereditary cancer syndromes.
authors.affiliation: Program Resources Inc. (Division of Dynacorp Inc.), Frederick.
authors.forename: B
authors.initials: B
authors.lastname: Zbar
authors.forename: K
authors.initials: K
authors.lastname: Tory
authors.forename: M
authors.initials: M
authors.lastname: Merino
authors.forename: L
authors.initials: L
authors.lastname: Schmidt
authors.forename: G
authors.initials: G
authors.lastname: Glenn
authors.forename: P
authors.initials: P
authors.lastname: Choyke
authors.forename: M M
authors.initials: MM
authors.lastname: Walther
authors.forename: M
authors.initials: M
authors.lastname: Lerman
authors.forename: W M
authors.initials: WM
authors.lastname: Linehan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged