Continuous succinylcholine infusion and phase II block in short surgical procedures.
The study was designed to observe continuous succinylcholine infusion and phase II block in short surgical procedures (duration < 90 min). The characteristics of neuromuscular blockade produced by continuous succinylcholine infusion were observed in 15 adult patients anesthetized with nitrous-oxide-isoflurane (0.7% end tidal concentration) and fentanyl, and were compared with the single-dose technique (n = 13) in recovery time. Ulnar nerve was stimulated supramaximally with repeated train-of-four (interval = 10 sec, frequency = 2 Hz) via surface electrodes at the wrist using an electromyographic monitor (Datex, Relaxograph, Finland). The infusion rate was adjusted to maintain the height of the first twitch (T1) in each train of four at 5-10% of control twitch height. The mean duration of infusion was 50.74 +/- 18.06 minutes. The steady state infusion rate required to maintain 90% to 95% twitch depression was 83.5 +/- 21.4 micrograms/kg/min. Five patients developed phase II block (T4/T1 < 0.5) designated as IB. The other ten did not develop phase II block as IA. Recovery times (T1 = 10.50%, 10-100%) between IA and IB were not statistically significantly different. The recovery time of train-of-four fade (T1 = 10% to T1 = 100% and train of four > 75%) was 5.73 +/- 0.43 minutes. However, recovery times between continuous infusion group and single dose group were significantly different.(ABSTRACT TRUNCATED AT 250 WORDS)
Chen
Y A
YA
Department of Anesthesiology, National Taiwan University Hospital, Taipei, R.O.C.
Fan
S Z
SZ
Lee
P C
PC
Shi
J J
JJ
Tsai
Y C
YC
Chang
C L
CL
Liu
C C
CC
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects*; D013390:Succinylcholine / Q000008:administration & dosage*; D013997:Time Factors
D013390:Succinylcholine