title: Comparison of the effects of single morning and single bedtime doses of famotidine on intragastric acidity in patients with gastric ulcer.
abstract: The effects of single morning and single bedtime doses of famotidine on intragastric acidity were studied by 24-h intragastric pH monitoring in 16 patients with gastric ulcer. The patients were randomly allocated to the following regimen: one group (n = 8) received 40 mg famotidine at 8:30 AM and another group (n = 8) received the same dose at 10 PM. The morning group showed significant inhibition of gastric acidity during the 24-h and daytime measurements, compared to those of the bedtime group (p < 0.05 in 24 h, p < 0.01 in daytime). Conversely, the bedtime group showed a significant inhibition of gastric acidity during the nocturnal period compared to the morning group (p < 0.01). These results indicate that the relative importance of suppression of gastric acidity on the gastric ulcer healing process should be evaluated in a clinical trial.
authors.affiliation: Department of Gastroenterology, Fukuoka University Chikushi Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Arita
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: A
authors.initials: A
authors.lastname: Motomura
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: K
authors.initials: K
authors.lastname: Hosiko
authors.forename: T
authors.initials: T
authors.lastname: Yao
mesh_terms: D004334:Drug Administration Schedule; D015738:Famotidine / Q000008:administration & dosage*; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D015738:Famotidine