title: Detection of antineutrophil cytoplasmatic antibodies (ANCA) and their association with other autoantibodies in patients with hepatobiliary disorders.
abstract: Sera from 35 out of 655 patients with suspected or confirmed hepatobiliary diseases were positive for anti-neutrophil antibodies with a perinuclear staining pattern (p-ANCA). Nineteen of these sera did not react with myeloperoxidase (MPO), Cathepsin G or Elastase, the three proposed antigens of p-ANCAs. No distinct antigen for these sera could be characterized by western blot techniques with fractionated granulocyte proteins.
authors.affiliation: Institute for Immunology, University of Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Gruber
authors.forename: C
authors.initials: C
authors.lastname: Brockmeyer
authors.forename: W
authors.initials: W
authors.lastname: Hoechtlen-Vollmar
authors.forename: R
authors.initials: R
authors.lastname: Bittlingmaier
authors.forename: S
authors.initials: S
authors.lastname: Trimborn
authors.forename: G
authors.initials: G
authors.lastname: Riethmüller
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood*; D001660:Biliary Tract Diseases / Q000276:immunology*; D015153:Blotting, Western; D056649:Cathepsin G; D002403:Cathepsins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008107:Liver Diseases / Q000276:immunology*; D010196:Pancreatic Elastase / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D012697:Serine Endopeptidases
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G; D009195:Peroxidase; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase