Synthesis and biological evaluation of analogues of 5,8-dideazaisofolic acid (IAHQ) modified at positions 2, 4 and 9.
Hynes
J B
JB
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425.
Hagan
R L
RL
Shane
B
B
Freisheim
J H
JH
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007700:Kinetics; D007939:Leukemia L1210; D008099:Liver / Q000201:enzymology; D051379:Mice; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D013552:Swine; D014407:Tumor Cells, Cultured
D005493:Folic Acid Antagonists; D011799:Quinazolines; C035530:5,8-dideazaisofolic acid; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase