[Protective effect of nerve growth factor on cholinergic neurons corpus striatum of new born rat subjected to hypoxia-ischemia].
Cerebral hypoxia-ischemia was produced in 7 day old rats by right common carotid artery occlusion combined with systemic hypoxia. In the hypoxic-ischemic group animals, striatal ACh contents on both sides were reduced to a significant extent in commensurate to AChE histochemical image analysis. All these changes could be restored to normal control by a protection dose (50 micrograms) of NGF intraventricularly injected.
Yu
X H
XH
Department of Physiology, First Medical University of PLA, Guangzhou.
Hua
Z W
ZW
Li
Y S
YS
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology; D017536:Carotid Artery, Common / Q000601:surgery; D003342:Corpus Striatum / Q000378:metabolism*; D007276:Injections, Intraventricular; D008026:Ligation; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D009414:Nerve Growth Factors; D000109:Acetylcholine