Inhibitory effect of tannin in green tea on the proliferation of mesangial cells.
The effect of green tea tannin on the proliferation of mesangial cells was determined in terms of [3H]thymidine uptake. When green tea tannin was added to the medium of mesangial cell cultures, it suppressed the proliferation of mesangial cells markedly. In particular, (-)-epigallocatechin 3-O-gallate, the predominant component of the green tea tannin mixture, exerted an inhibitory effect at a relatively low concentration, suggesting a direct corroboration of the renal effects.
Yokozawa
T
T
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Oura
H
H
Hattori
M
M
Iwano
M
M
Dohi
K
K
Sakanaka
S
S
Kim
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D005260:Female; D005920:Glomerular Mesangium / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D013634:Tannins / Q000032:analysis* / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D013936:Thymidine / Q000378:metabolism
D013634:Tannins; D013662:Tea; D004247:DNA; D013936:Thymidine