title: Connection topology of proteins.
abstract: One-dimensional amino acid sequences and three-dimensional folded polypeptide chains were modelled as non-directed graphs in which nodes corresponded to amino acids and arcs represented connections between them. In the case of folded chains, non-backbone connections were assigned to amino acid pairs if their distance was lower than a threshold. Two topological indices, the connectedness number and the effective chain length were devised to compare folding topologies. Loops created by non-backbone connections in the structure graphs were studied by simple graphical representations, revealing the hierarchy in native protein structures.
authors.affiliation: Laboratory of Mathematical Biology, National Institute for Medical Research, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Aszódi
authors.forename: W R
authors.initials: WR
authors.lastname: Taylor
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003196:Computer Graphics; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D011506:Proteins