Effects of an acute bolus growth hormone infusion on the human immune system.
This study was performed to examine the in vivo effects of a bolus of recombinant human growth hormone (r-hGH) on the human immune system. In a double blind placebo controlled cross over study, healthy volunteers were given 2 IU r-hGH as an intravenous infusion. r-hGH did not influence the subpopulations of blood mononuclear cells (BMNC), natural killer cell activity, in vitro proliferative responses or production of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2, IL-6, IL-8, tumor necrosis factor alpha (TNF alpha), TNF beta or interferon gamma in supernatants from BMNC stimulated with either lipopolysaccharide or phytohemagglutinin. However, two h after infusion a significant neutrocytosis occurred. It is concluded that a bolus infusion of r-hGH to healthy volunteers exerts only minor effects on the human immune system.
Kappel
M
M
Department of Infectious Diseases, Rigshospitalet, State University Hospital, Copenhagen, Denmark.
Hansen
M B
MB
Diamant
M
M
Jørgensen
J O
JO
Gyhrs
A
A
Pedersen
B K
BK
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D004311:Double-Blind Method; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007262:Infusions, Intravenous; D007371:Interferon-gamma / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis; D007700:Kinetics; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000166:cytology; D010919:Placebos; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D015703:Antigens, CD; D007378:Interleukins; D010919:Placebos; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D013006:Growth Hormone