Renal toxicity of nickel, sodium lauryl sulphate and their combination after dermal application in guinea pigs.
The guinea pigs were dermally exposed to nickel (Ni), sodium lauryl sulphate (SLS) and in their combination for 7 and 14 days. The exposure to Ni and SLS produced changes in enzymes and lipid peroxidation in kidney. The exposure to Ni or SLS depicted slight changes while combined exposure to Ni plus SLS exhibited more degenerative changes in kidney. The result of the study suggests that industrial workers and/or populations exposed simultaneously to Ni and SLS produces more damage to kidney.
Mathur
A K
AK
Industrial Toxicology Research Centre, P.B.No, 80, Lucknow, India.
Gupta
B N
BN
Singh
A
A
Singh
S
S
Shanker
R
R
D000279:Administration, Cutaneous; D000818:Animals; D006168:Guinea Pigs; D007674:Kidney Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D009532:Nickel / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D012869:Skin Absorption / Q000502:physiology*; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*
D012967:Sodium Dodecyl Sulfate; D009532:Nickel