A novel adhesion protein expressed by ciliated epithelium, hemocytes, and leukemia cells in soft-shell clams.
The ontogeny of circulating hemocytes and tumor cells in mollusks has been approached using monoclonal antibodies to normal cells. A monoclonal antibody, previously shown to identify an adhesion related protein (p130), has been used to define the reactivity of cells in tissues from normal soft-shell clams (Mya arenaria) and soft-shell clams with leukemia. Using immunoperoxidase technology, we have determined that hemocytes, connective tissue cells, and a subset of leukemia cells that are adherent share a cross-reactive epitope with cilia.
Smolowitz
R M
RM
Laboratory for Marine Animal Health, School of Veterinary Medicine, University of Pennsylvania.
Reinisch
C L
CL
D000818:Animals; D000911:Antibodies, Monoclonal; D049872:Bivalvia / Q000166:cytology / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D002923:Cilia; D003239:Connective Tissue Cells; D004848:Epithelium / Q000276:immunology; D006434:Hemocytes / Q000276:immunology; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007938:Leukemia / Q000276:immunology / Q000662:veterinary; D051379:Mice; D008807:Mice, Inbred BALB C
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules