title: Bilateral induction of NADPH-diaphorase activity in neocortical and hippocampal neurons by unilateral injury.
abstract: Unilateral injury of the cerebral cortex or hippocampus induced a bilateral appearance of NADPH-diaphorase in some pyramidal neuronal and glial cells of both structures. Only in the cerebral cortex, near the needle track, did some V layer pyramidal neurons contain so much of this enzyme that they looked to be stained by the Golgi method. The induction of NADPH-diaphorase in a subset of cortical and hippocampal neurons in both hemispheres after unilateral injections of either cysteamine or artificial cerebro-spinal fluid suggests the existence in the isocortex and the hippocampus of a selective signalling system which may play a role in recovery of function following local brain damage.
authors.affiliation: Department of Morphology, Faculty of Health Science, University of Las Palmas de Gran Canaria, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Regidor
authors.forename: J
authors.initials: J
authors.lastname: Montesdeoca
authors.forename: J A
authors.initials: JA
authors.lastname: Ramirez-Gonzalez
authors.forename: C M
authors.initials: CM
authors.lastname: Hernandez-Urquia
authors.forename: I
authors.initials: I
authors.lastname: Divac
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology* / Q000473:pathology; D003543:Cysteamine; D004790:Enzyme Induction; D005260:Female; D006624:Hippocampus / Q000201:enzymology* / Q000473:pathology; D006651:Histocytochemistry; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values
chemical_list: D003543:Cysteamine; D009252:NADPH Dehydrogenase