title: Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.
abstract: Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Umezawa
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: I
authors.initials: I
authors.lastname: Kijima-Suda
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: K
authors.initials: K
authors.lastname: Sugawara
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D014764:Viral Proteins / Q000037:antagonists & inhibitors
chemical_list: D000998:Antiviral Agents; D010880:Piperidines; D014764:Viral Proteins; C011353:siastatin; D009439:Neuraminidase