Recombinant interferon-alpha efficacy in relapsed adult nephroblastoma: a case report.
We report on a 37-year-old woman with progressive lung and pleural metastases from a right nephroblastoma, who achieved partial remission with recombinant interferon-alpha. The drug was given subcutaneously at a dose of 5 mu. 3 times per week. The response was documented after 3 months of treatment and was maintained for at least 9 months. Although such a response has not been reported in the literature, this case suggests promising activity of recombinant interferon-alpha in relapsed nephroblastoma.
Kattan
J
J
Department of Medicine, Institut Gustave-Roussy, Villejuif, France.
Droz
J P
JP
Culine
S
S
Escudier
B
B
Beaumont-Raymond
C
C
D000328:Adult; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D010997:Pleural Neoplasms / Q000556:secondary / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction; D009396:Wilms Tumor / Q000556:secondary / Q000628:therapy*
D016898:Interferon-alpha; D011994:Recombinant Proteins