[The effect of the eradication of H. pylori on the intractable ulcer].
On 25 cases (gastric ulcer 14 cases and duodenal ulcer 11 cases) of the intractable ulcer which was H. pylori-positive, we eradicated H. pylori. The eradication was done during 14 days by a triple therapy: bismuth subnitrate 2.0 g, metronidazole 0.75 g, AMPC 0.75 g/day). All cases were confirmed to be eradicated by culture and microscopic examination. 24 cases (gastric ulcer 13/14 and duodenal ulcer 11/11) were confirmed to be completely cured. After the eradication, we ceased the maintenance therapy by H2RA and followed them up, however, no ulcer relapses were found up to 9 months. It was considered that the eradication against H. pylori was a very effective method to the intractable ulcer.
Kihira
K
K
Department of Gastroenterology, Jichi Medical School.
Sato
K
K
Yoshida
Y
Y
Takimoto
T
T
Taniguchi
Y
Y
Kimura
K
K
D000667:Ampicillin / Q000008:administration & dosage; D001729:Bismuth / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000517:prevention & control; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D012008:Recurrence
D008795:Metronidazole; D000667:Ampicillin; C010804:bismuth subnitrate; D001729:Bismuth