Paratesticular rhabdomyosarcoma: delayed effects of multimodality therapy and implications for current management.
BACKGROUND
The combined modalities of surgery, chemotherapy, and radiation therapy have greatly improved the survival rate in childhood paratesticular rhabdomyosarcoma, but the incidence of complications and late side effects is a cause for concern.


METHODS
We reviewed the records of 18 patients treated for paratesticular rhabdomyosarcoma at St. Jude Children's Research Hospital between 1962 and 1989. Patients with Group I disease were treated with orchiectomy, retroperitoneal lymph node dissection, and multi-agent chemotherapy; more advanced cases also received radiation therapy with concurrent chemotherapy.


RESULTS
Sequelae included esophageal and common bile duct stricture, inguinal nerve entrapment syndrome, and small bowel obstruction. Short stature was found in all children whose spines were irradiated via para-aortic fields (34-37 Gy) prior to puberty. Two of 18 patients died from treatment complications and one from progressive disease.


CONCLUSIONS
Multimodality treatment offers an excellent prognosis in paratesticular rhabdomyosarcoma, but is associated with significant morbidity and mortality rates. A discussion of therapy components and their application to disease stages suggests possible approaches to optimizing treatment for this therapy-sensitive malignancy.
Hughes
L L
LL
Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Baruzzi
M J
MJ
Ribeiro
R C
RC
Ayers
G D
GD
Rao
B
B
Parham
D M
DM
Pratt
C B
CB
Kun
L E
LE
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects; D011379:Prognosis; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012208:Rhabdomyosarcoma / Q000401:mortality / Q000628:therapy*; D013736:Testicular Neoplasms / Q000401:mortality / Q000628:therapy*; D013997:Time Factors