Does a genetically determined aggressive locomotion favour the establishment of intracellular macrophage parasites?
A novel computerized methodology was used to quantify, for the first time, the 3-dimensional locomotory phenotypes of individual macrophages moving within an extracellular matrix-like hydrated collagen lattice/gel. Comparisons between two macrophage lines genetically susceptible to intracellular parasites (B10S4 and ANA-1) and two genetically resistant (B10R4 and CD2) demonstrated that Bcgs alleles consistently endowed macrophages with an outward searching and active locomotion, whereas Bcgr imparted a retrocessive phenotype. Several different macrophage pathogens may have exploited this genetically determined aggressive locomotory behavior of susceptible macrophages to allow them to rapidly enter a sanctuary.
Shields
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ED
Department of Oral Biology, Faculty of Dentistry, McGill University, Montreal, Que., Canada.
Noble
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PB
Radzioch
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D
D000483:Alleles; D000818:Animals; D001854:Bone Marrow Cells; D002460:Cell Line; D002465:Cell Movement / Q000502:physiology; D004198:Disease Susceptibility; D005782:Gels; D005809:Genes, Regulator / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D008264:Macrophages / Q000166:cytology* / Q000469:parasitology* / Q000502:physiology; D051379:Mice; D010272:Parasitic Diseases; D010641:Phenotype
D005782:Gels