[A patient with hepatoma and hepatic cirrhosis showing abnormally high blood morphine concentration after periodical suppository administration].
Morphine hydrochloride 10 mg suppository was given every 6 hours in a patient with hepatoma and hepatic cirrhosis. The serum morphine concentration increased continuously until 4 hours after the second administration, and peak level showed 17 ng.ml-1. Morphine-6-glucuronide and morphine-3-glucuronide in the serum persisted at low levels of 32.4 ng.ml-1 and 169 ng.ml-1 respectively. Three days after the administration, morphine suppository had to be discontinued because of severe nausea and vomiting. It should be noticed that a remarkable reduction in morphine metabolism may occur and this may lead to unexpected high serum concentration of morphine in a patient with hepatic dysfunction.
Kameue
T
T
Department of Anesthesia, Rumoi City General Hospital.
Matoba
M
M
Ogawa
H
H
D001859:Bone Neoplasms / Q000503:physiopathology / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000150:complications / Q000556:secondary; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000097:blood*; D010148:Intractable Pain / Q000097:blood / Q000188:drug therapy; D013488:Suppositories
D013488:Suppositories; D009020:Morphine