Capillary permeability in experimental rat glioma and effects of intracarotid CDDP administration on tumor drug delivery.
We have examined the capillary permeability within and adjacent to experimental rat gliomas, and the effect of intracarotid administration of cisplatin in this model. Permeability to 14C-sucrose was 25-fold and six-fold higher within the brain tumor and in the tumor periphery and adjacent tissue respectively than in the normal cortex. Intracarotid administration of cisplatin resulted in ten-fold increase in experimental gliomas and also a significant increase in the tumor periphery and adjacent tissue, when compared to the intravenous route. Intracarotid administration of cisplatin to rat did not cause acute vascular damage in either the brain or brain tumor at the dosage used.
Ichimura
K
K
Department of Neurosurgery, Tokyo Medical and Dental University, Japan.
Ohno
K
K
Aoyagi
M
M
Tamaki
M
M
Suzuki
R
R
Hirakawa
K
K
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001932:Brain Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000503:physiopathology*; D002196:Capillaries / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects*; D002342:Carotid Artery, External; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005910:Glioma / Q000098:blood supply / Q000188:drug therapy / Q000503:physiopathology*; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D009543:Nifedipine; D002945:Cisplatin