title: Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA): clinical significance and relation to antibodies against myeloid lysosomal enzymes.
abstract: In a prospective study of 27 months duration p-ANCA were found in 120 patients. 35% of these patients had vasculitis and/or glomerulonephritis. 28% of the p-ANCA positive sera reacted with myeloid lysosomal enzymes.
authors.affiliation: Department of Clinical Immunology, University Hospital Groningen, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Tervaert
authors.forename: A H
authors.initials: AH
authors.lastname: Mulder
authors.forename: C G
authors.initials: CG
authors.lastname: Kallenberg
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D053146:Myeloblastin; D009504:Neutrophils / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D011446:Prospective Studies; D012697:Serine Endopeptidases / Q000276:immunology; D014657:Vasculitis / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D009195:Peroxidase; D012697:Serine Endopeptidases; D010196:Pancreatic Elastase; D053146:Myeloblastin