[The effect of hemodialysis on the level of cytoplasmic Ca2+ in the thrombocytes of patients with chronic kidney failure].
Cytoplasmic Ca2+ was measured in donors and 12 patients with chronic renal failure (CRF) on hemodialysis. Their basal platelet levels were approximately the same. With longer duration of the dialysis Ca2+ levels decreased. Thrombin-induced platelet production of Ca2+ in patients proved significantly lower than in donors, but the dialysis promoted a rise in both basal and thrombin-induced cytoplasmic Ca2+ levels. Greater concentrations of Ca2+ towards the end of the dialysis are supposed to result from reestablishment of its storage pools both in depositing granules and, primarily, in the dense tubular system.
Rud'ko
I A
IA
Kubatiev
A A
AA
Tsalenchuk
Ia P
IaP
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry* / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D003593:Cytoplasm / Q000737:chemistry* / Q000187:drug effects; D005921:Glomerulonephritis / Q000097:blood / Q000628:therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008875:Middle Aged; D011704:Pyelonephritis / Q000097:blood / Q000628:therapy; D006435:Renal Dialysis; D013917:Thrombin / Q000494:pharmacology
D013917:Thrombin; D002118:Calcium
Vliianie gemodializa na soderzhanie tsitoplazmaticheskogo Ca2+ v trombotsitakh bol'nykh khronicheskoĭ pochechnoĭ nedostatochnost'iu.