title: Effects of ischemia-reperfusion on light-evoked alkalinization outside rod photoreceptors in the cat retina.
abstract: The effects of ischemia-reperfusion on the light-evoked alkalinization, which reflects the metabolism of rod photoreceptors, were studied in the dark-adapted cat retina in vivo. We recorded the pH value in the extracellular space surrounding rod photoreceptors with double-barreled H(+)-selective microelectrodes. The light-evoked alkalinizations at the outer nuclear layer were diminished during reperfusion after 10-30 min of ischemia which was induced by an increase of the intraocular pressure above the arterial systolic pressure. This result suggests that the rod metabolism might be suppressed during reperfusion after ischemia.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Hiroi
authors.forename: Y
authors.initials: Y
authors.lastname: Honda
mesh_terms: D000818:Animals; D002415:Cats; D003623:Dark Adaptation; D004195:Disease Models, Animal; D004596:Electroretinography; D006863:Hydrogen-Ion Concentration; D007511:Ischemia / Q000378:metabolism* / Q000503:physiopathology; D008027:Light; D008839:Microelectrodes; D015424:Reperfusion; D017948:Retinal Rod Photoreceptor Cells / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism*