Low affinity nerve growth factor receptor, adrenal transplant and Parkinson's disease.
Immunohistochemistry of low-affinity nerve growth factor receptor (LNGFR) was performed postmortem in the striatum and the adrenal gland of a parkinsonian patient with an adrenal to brain transplantation. Few LNGFR-positive fibers were observed in the necrotic graft. By contrast numerous immunostained fibers were detected in a restricted zone of the host striatum adjacent to the graft, corresponding to a selective zone of sprouting of tyrosine hydroxylase-positive fibers. This suggests that nerve growth factor or related growth factors may promote sprouting of catecholaminergic fibers in the host striatum.
Strada
O
O
INSERM U 289, Hôpital de la Salpêtière, Paris, France.
Hirsch
E C
EC
Javoy-Agid
F
F
Duyckaerts
C
C
Hauw
J J
JJ
Agid
Y
Y
D000313:Adrenal Medulla / Q000378:metabolism* / Q000473:pathology / Q000637:transplantation*; D001344:Autopsy; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D017475:Receptors, Nerve Growth Factor / Q000032:analysis / Q000378:metabolism*; D014182:Transplantation, Autologous; D016042:Transplantation, Heterotopic
D017475:Receptors, Nerve Growth Factor; D007980:Levodopa