Mutations of human dihydrofolate reductase causing decreased inhibition by methotrexate.
Blakley
R L
RL
Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38101.
Appleman
J R
JR
Chunduru
S K
SK
Nakano
T
T
Lewis
W S
WS
Harris
S E
SE
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006224:Cricetinae; D004926:Escherichia coli; D005492:Folic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D005493:Folic Acid Antagonists; D014644:Genetic Variation; D006801:Humans; D007700:Kinetics; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics* / Q000378:metabolism
D005493:Folic Acid Antagonists; D011994:Recombinant Proteins; C010920:dihydrofolate; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate