The effect of laminin on molecular motion in the cell membrane and on cell motility.
We have studied the variation of lateral diffusion of proteins in the cell membrane, of membrane lipid fluidity and of the electrophoretic motility (EPM) of macrophages after treatment with extrinsic laminin. The results showed that the lateral diffusion coefficient D value of membrane proteins, the fluidity of membrane lipids and the EPM of macrophages were decreased after laminin had bound to its membrane receptor on the macrophages. These results are important for developing an understanding of the early reaction of plasma membranes and cells in the presence of laminin.
Wei
X
X
Department of Cell Biology, Beijing Medical University.
Wang
W
W
Fu
S
S
Yang
Z
Z
Lu
J
J
Yu
G
G
Tao
J
J
Su
Y
Y
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D004586:Electrophoresis; D007797:Laminin / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D008563:Membrane Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology; D017474:Receptors, Laminin / Q000378:metabolism
D007797:Laminin; D008563:Membrane Lipids; D008565:Membrane Proteins; D017474:Receptors, Laminin