title: Male siblings with schizophrenia share alleles at the androgen receptor above chance expectation.
abstract: In families that included two or more siblings with schizophrenia or schizo-affective disorder male-male pairs were found to share alleles at the androgen receptor (AR) gene (in Xq11.2-q12) above chance expectation (p < 0.003); female-female and mixed sex pairs showed no such tendency. The findings are compatible with X-Y linkage or with an X-linked contribution to liability in males.
authors.affiliation: Division of Psychiatry, Clinical Research Centre, Harrow, U.K.
authors.forename: T J
authors.initials: TJ
authors.lastname: Crow
authors.forename: M
authors.initials: M
authors.lastname: Poulter
authors.forename: R
authors.initials: R
authors.lastname: Lofthouse
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Shah
authors.forename: N
authors.initials: N
authors.lastname: Bass
authors.forename: C
authors.initials: C
authors.lastname: Morganti
authors.forename: A
authors.initials: A
authors.lastname: Vita
authors.forename: C
authors.initials: C
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Boccio-Smith
mesh_terms: D000483:Alleles; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011336:Probability; D011944:Receptors, Androgen / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D014960:X Chromosome
chemical_list: D011944:Receptors, Androgen