title: [Evaluation of 3 therapeutic schedules with N-methyl-glucamine antimonate in the treatment of visceral leishmaniasis in the state of Para, Brazil].
abstract: We have evaluated, in a retrospective manner, three chemotherapeutic schemes with meglumine antomoniate (Glucantime) use in the treatment of 43 autochthonous cases of visceral leishmaniasis in children in the age-group of 1-12 years old, during the period 1985-1990. Of the 43 cases, 28 (group A) were treated with 40mg/SbV/kg given IV at intervals of 48 hours, in courses of 15 applications (scheme I); 8 (group B) were treated with 40 mg/SbV/kg given IV daily during 15 days (scheme II), and 7 (group C) were treated with 20 mg/SbV/kg given IV daily during 15 days (scheme III). With the criteria for cure based essentially on clinical examination, we admitted that the scheme III would be the preferred for these reasons: a) it produces the same cure-rate as those schemes which use double this dosage, b) in relation to positive results it is less expensive, c) the scheme can be used for more extended periods, with less risk of toxic effects, and d) there has till now been no evidence of the development of resistance to treatment using this scheme, at least in our particular area of study (Pará).
authors.affiliation: Médico do Serviço de Parasitologia, Instituto Evandro Chagas (FNS), Belém, Pará, Brasil.
authors.forename: F T
authors.initials: FT
authors.lastname: Silveira
authors.forename: D A
authors.initials: DA
authors.lastname: Pingarilho
authors.forename: R R
authors.initials: RR
authors.lastname: Duarte
authors.forename: M do D
authors.initials: Mdo D
authors.lastname: Gabriel
authors.forename: M G
authors.initials: MG
authors.lastname: Dias
authors.forename: M P
authors.initials: MP
authors.lastname: Moura
authors.forename: M E
authors.initials: ME
authors.lastname: Braga
authors.forename: E X
authors.initials: EX
authors.lastname: Prestes
authors.forename: B C
authors.initials: BC
authors.lastname: Maués
mesh_terms: D001938:Brazil; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008536:Meglumine / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate
vernacular_title: Avaliação de três esquemas terapêuticos com o antimoniato de N-metil-glucamina no tratamento da leishmaniose visceral no estado do Pará, Brasil.