Thiomarinol, a new hybrid antimicrobial antibiotic produced by a marine bacterium. Fermentation, isolation, structure, and antimicrobial activity.
Thiomarinol, an antimicrobial antibiotic, was isolated from the culture broth of a marine bacterium, Alteromonas rava sp. nov. SANK 73390. Its structure was deduced as a hybrid composed of a pseudomonic acid analogue and holothin by NMR spectral analysis and chemical degradation. Antimicrobial activity against Gram-positive and Gram-negative bacteria of thiomarinol was stronger than both of pseudomonic acids and pyrrothine antibiotics.
Shiozawa
H
H
Biomedical Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Kagasaki
T
T
Kinoshita
T
T
Haruyama
H
H
Domon
H
H
Utsui
Y
Y
Kodama
K
K
Takahashi
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D006088:Gram-Negative Aerobic Bacteria / Q000737:chemistry* / Q000378:metabolism; D007769:Lactams; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007769:Lactams; C085617:thiomarinol; D016712:Mupirocin