title: [Antibody functional activity in immunization with influenza vaccines].
abstract: The functional activity of serum antibody had been shown previously to reflect the state of resistance to influenza more accurately than antibody concentration. The functional activity of antibodies in the vaccination process was studied. The immune response to influenza antigens was found to be accompanied by an increase in the functional activity of antibodies, the intensity of this increase was the highest in natural influenza infection, moderate after administration of live vaccines and the least after immunization with inactivated preparations. The vaccine strains may differ significantly in their capacity to stimulate antibody with high functional activity. The quantitative parameters of the functional activity of antibody are directly related to the antigen dose and frequency of antigenic stimulation.
authors.forename: A N
authors.initials: AN
authors.lastname: Naĭkhin
authors.forename: S A
authors.initials: SA
authors.lastname: Artem'eva
authors.forename: T A
authors.initials: TA
authors.lastname: Ermachenko
authors.forename: E N
authors.initials: EN
authors.lastname: Vybornykh
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Kustikova
authors.forename: E V
authors.initials: EV
authors.lastname: Doroshenko
authors.forename: L G
authors.initials: LG
authors.lastname: Katorgina
authors.forename: G M
authors.initials: GM
authors.lastname: Denisov
authors.forename: T N
authors.initials: TN
authors.lastname: Kim
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
vernacular_title: Funktsional'naia aktivnost' antitel pri immunizatsii grippoznymi vaktsinami.