Sulphonamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.
Pawełczak
K
K
Institute of Chemistry, Pedagogical University of Opole, Poland.
Makowski
M
M
Kempny
M
M
Dzik
J M
JM
Balińska
M
M
Rode
W
W
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005493:Folic Acid Antagonists / Q000494:pharmacology* / Q000633:toxicity; D007202:Indicators and Reagents; D007940:Leukemia L5178; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
D005493:Folic Acid Antagonists; D007202:Indicators and Reagents; D013449:Sulfonamides; D013940:Thymidylate Synthase