title: Lung resection after high doses of mediastinal radiotherapy (sixty grays or more). Reinforcement of bronchial healing with thoracic muscle flaps in nine cases.
abstract: Mediastinal radiotherapy of more than 60 Gy highly compromises bronchial and wound healing after lung resection. Nine patients with primary lung cancers underwent radical resection after high radiation doses. Eight patients had primary lung cancer previously treated by radiotherapy alone (n = 2) or associated with chemotherapy (n = 6). One patient had a tracheal cancer involving the carina that was previously treated by radiotherapy. Seven patients underwent pneumonectomy and one patient underwent lobectomy with reinforcement of bronchial stump closure with use of the serratus anterior muscle. One patient underwent a sleeve lobectomy with bronchial reconstruction wrapped with an intercostal pedicle flap. Five patients had no postoperative complications and four patients had empyema, one associated with a small bronchial fistula. All except one patient were successfully treated by thoracostomy and immediate or secondary transposition of the pectoralis major muscle and the omentum to fill the cavity. These results show that lung resections can be done after high doses of radiotherapy without a high rate of bronchial fistula by using thoracic muscle flaps to reinforce bronchial stumps and anastomoses. In this procedure, surgical dissection is more time-consuming and increases the postoperative empyema rate (4/9). However, the higher long-term survival may justify this choice in selected cases.
authors.affiliation: Department of Thoracic and Vascular Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Regnard
authors.forename: P
authors.initials: P
authors.lastname: Icard
authors.forename: M
authors.initials: M
authors.lastname: Deneuville
authors.forename: B
authors.initials: B
authors.lastname: Jauffret
authors.forename: P
authors.initials: P
authors.lastname: Magdeleinat
authors.forename: J F
authors.initials: JF
authors.lastname: Levi
authors.forename: P
authors.initials: P
authors.lastname: Levasseur
mesh_terms: D000328:Adult; D000368:Aged; D001980:Bronchi / Q000601:surgery; D001983:Bronchial Fistula / Q000209:etiology; D003131:Combined Modality Therapy; D004653:Empyema / Q000209:etiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011013:Pneumonectomy; D011183:Postoperative Complications; D013524:Surgical Flaps; D014945:Wound Healing