Hypothalamic norepinephrine depletion inhibits CRF-41 release following neural stimuli.
The effects of depletion of hypothalamic norepinephrine (NE) on median eminence (ME)-corticotropin-releasing factor (CRF-41) content, serum ACTH and corticosterone (CS) levels, following photic and acoustic stimulation, were investigated. While in intact rats these stimuli caused depletion in CRF-41 and a rise in ACTH and CS level, in rats pretreated with 6-hydroxydopamine (6-OHDA), these effects were prevented. This would suggest that the blockage in the release of ME CRF-41 into the portal plasma following neural stimuli in rats with hypothalamic NE depletion, is responsible for the inhibition of the pituitary-adrenocortical response.
Feldman
S
S
Department of Neurology, Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Weidenfeld
J
J
D000161:Acoustic Stimulation; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism* / Q000502:physiology; D016627:Oxidopamine / Q000494:pharmacology; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010775:Photic Stimulation; D051381:Rats
D016627:Oxidopamine; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine