title: Platelet inhibition with ASA/dipyridamole after percutaneous balloon angioplasty in patients with symptomatic lower limb arterial disease. A prospective double-blind trial. Study group on pharmacological treatment after PTA.
abstract: A randomised double-blind multicentre trial has been performed comparing the influence of 3 months prophylaxis with acetylsalicylic acid/dipyridamole (50 mg/400 mg daily) or placebo on the outcome following percutaneous transluminal angioplasty for lower limb ischaemia. Two hundred and twenty-three patients were included and followed. There were no differences between the groups regarding results 1, 3, 6 and 12 months following the dilatation treatment. It can be concluded that acetylsalicylic acid at the dose of 50 mg daily combined with dipyridamole does not seem to have a prophylactic effect after transluminal angioplasty during a follow-up period of 1 year.
mesh_terms: D000368:Aged; D000792:Angiography; D000800:Angioplasty, Balloon / Q000009:adverse effects; D001241:Aspirin / Q000008:administration & dosage*; D004176:Dipyridamole / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000517:prevention & control / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D014654:Vascular Patency / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D004176:Dipyridamole; D001241:Aspirin