Sumatriptan blocks neurogenic inflammation in the peripheral nerve trunk.
We tested the action of intraperitoneal sumatriptan, a 5-HT1D receptor agonist that aborts migraine headaches, using a model of neurogenic inflammation induced by capsaicin applied to the rat sciatic epineurium. Sumatriptan prevented the development of capsaicin-induced hyperemia without inducing pretreatment vasoconstriction or altering AV shunt flow. The findings indicate that sumatriptan prevents "neurogenic" vasodilation by a mechanism other than vasoconstriction or changes in AV shunt flow.
Zochodne
D W
DW
University of Calgary, Department of Clinical Neurosciences, AB, Canada.
Ho
L T
LT
D000818:Animals; D002211:Capsaicin / Q000037:antagonists & inhibitors; D006940:Hyperemia / Q000139:chemically induced; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009443:Neuritis / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D012584:Sciatic Nerve / Q000098:blood supply; D018170:Sumatriptan / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D018170:Sumatriptan; D002211:Capsaicin