New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis.
Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.
Das-Gupta
E P
EP
Department of Rheumatology, University of Manchester, UK.
Lyons
T J
TJ
Hoyland
J A
JA
Lawton
D M
DM
Freemont
A J
AJ
D000208:Acute Disease; D000375:Aging; D000818:Animals; D001842:Bone and Bones / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D002908:Chronic Disease; D004195:Disease Models, Animal; D005121:Extremities; D007596:Joints / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010003:Osteoarthritis / Q000473:pathology*; D010865:Pilot Projects; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000473:pathology