title: Determinants of midwall circumferential segmental length of the canine ventricular septum at end diastole.
abstract: The ventricular septum attaches to the insertion points of the ventricular free walls, separates, and is shared by both the left (LV) and right (RV) ventricles. Changes in the transseptal pressure gradient (PTS, the difference between LV and RV pressures) will change the stress in the septum and, therefore, the length of the septal segment (Ls). However, since most of the septal myocardial fibers are continuous with those of LV free wall and the septum appears to be an integral part of LV, one might also expect that if the LV transmural pressure (Plvtm; the difference between LV and pericardial pressure) is raised, Ls would increase even in the absence of any change in PTS. Therefore, we hypothesized that at end diastole, Ls depends on both Plvtm and PTS. To test this hypothesis, we measured Ls (sonomicrometry), LV and RV pressures (micromanometers), and pericardial pressure (flat liquid-containing balloon) in seven anesthetized open-chest dogs. Plvtm was increased through volume loading, whereas PTS was maintained constant at 10, 5, 0, -5, -10, and -15 mmHg by adjusting the degree of constriction of the pulmonary artery or aorta. These procedures were performed first with pericardium reapproximated and then after the pericardium had been opened widely. At each controlled PTS level, Ls increased linearly with the increase in Plvtm. Both the slope and the intercept of this Ls-Plvtm relation were affected by PTS in a nonlinear fashion. (ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of Calgary, Alberta, Canada.
authors.forename: S J
authors.initials: SJ
authors.lastname: Dong
authors.forename: R
authors.initials: R
authors.lastname: Beyar
authors.forename: Z N
authors.initials: ZN
authors.lastname: Zhou
authors.forename: G H
authors.initials: GH
authors.lastname: Fick
authors.forename: E R
authors.initials: ER
authors.lastname: Smith
authors.forename: J V
authors.initials: JV
authors.lastname: Tyberg
mesh_terms: D000818:Animals; D001011:Aorta; D003250:Constriction; D003971:Diastole; D004285:Dogs; D005260:Female; D006346:Heart Septum / Q000502:physiology*; D008297:Male; D008955:Models, Cardiovascular; D010496:Pericardium / Q000502:physiology; D011651:Pulmonary Artery; D012044:Regression Analysis; D016276:Ventricular Function