Peripheral peptide YY induces c-fos-like immunoreactivity in the rat brain.
The influence of peripheral injection of peptide YY (PYY) on neuronal activity in the rat brain was examined by immunohistochemical detection of c-fos protein. Numerous c-fos-immunoreactive nuclei were found in the area postrema, nucleus tractus solitarius (commissural and medial subnuclei), central amygdala and thalamus (periventricular and medial) of rats injected i.p. with PYY at a dose of 300 micrograms/kg. c-fos-like immunoreactivity was found to be less when lower doses of PYY (50-200 micrograms/kg, i.p.) were injected. Either no or few cells were detected after i.p. injection of the vehicle alone. These data provide anatomical support for the centrally mediated actions of peripheral PYY on gut function.
Bonaz
B
B
CURE/Digestive Disease Center, VA Wadsworth Medical Center, Los Angeles, CA.
Taylor
I
I
Taché
Y
Y
D000679:Amygdala / Q000033:anatomy & histology / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002467:Cell Nucleus / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D008297:Male; D019894:Peptide YY; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000033:anatomy & histology / Q000378:metabolism; D013788:Thalamus / Q000033:anatomy & histology / Q000378:metabolism; D014630:Vagus Nerve / Q000033:anatomy & histology / Q000378:metabolism
D005768:Gastrointestinal Hormones; D010455:Peptides; D016760:Proto-Oncogene Proteins c-fos; D019894:Peptide YY