A pilot study of cisplatin based combination chemotherapy in gastric cancer.
A pilot study evaluating cisplatin in combination with 5-fluorouracil, methotrexate and epirubicin in advanced gastric cancer was initiated. Twenty patients were treated, eight with locally advanced or recurrent disease, and 12 with metastatic gastric cancer. The overall response rate was 35% (95% confidence interval 14%-56%).
McDonald
A
A
Department of Medical Oncology, Glasgow Royal Infirmary, UK.
Harding
M
M
McNulty
L
L
Cunningham
D
D
Soukop
M
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage*; D015251:Epirubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010865:Pilot Projects; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy*
D015251:Epirubicin; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate