[Amenorrhea, insulin resistance and acanthosis nigricans. A hyperandrogenic and a normoandrogenic clinical forms].
Two cases of HAIR-AN syndrome (hyperandrogenism, insulin resistance and acanthosis nigricans) are presented. The first case corresponds to a female with a systemic lupus erythematosus and acanthosis nigricans in which an insulin resistance was documented; the patient was in amenorrhea with severe hypoestrogenism, although she did not have clinical signs of hyperandrogenism and serum androgen levels were normal. This case corresponds to a HAIR-AN syndrome associated to autoimmune diseases or type A of Kahn. The second case is a young female with clinical signs of hyperandrogenism associated to high testosterone levels; she had acanthosis nigricans and fasting and postprandial hyperinsulinemia. Probably, this case corresponds to a type A or C HAIR-AN syndrome in which there is a decrease in the number of insulin receptors or a post receptor defect in insulin action.
Devoto
E
E
Departamento de Endocrinología, Hospital Clínico San Borja-Arriarán, Santiago de Chile.
Aravena
L
L
Pacheco
D
D
Fluxá
F
F
D000052:Acanthosis Nigricans / Q000097:blood / Q000503:physiopathology*; D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000503:physiopathology*; D000728:Androgens / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011972:Receptor, Insulin / Q000276:immunology; D013577:Syndrome
D000728:Androgens; D001786:Blood Glucose; D011972:Receptor, Insulin
Amenorrea, resistencia insulínica y acantosis nigricans. Una forma clínica hiperandrogenica y otra normoandrogenica.