title: Enhanced robotic dissolution system with concurrent off-line analysis.
abstract: A Zymate II robotic dissolution system was modified by addition of a liquid chromatography (LC) system equipped with an Isco ISIS autosampler. Using the Concurrent EasyLab programming language, operation of this LC system was integrated into the main robotic dissolution procedure. This enabled simultaneous dissolution sampling and LC analysis of standard and pre-pulled sample solutions. The resulting dual-tasking system effects considerable efficiency of operation and results in significant time savings. Comparison of the robotic and non-robotic data indicate good correlation and statistically insignificant differences at the 95% confidence level. Validation studies confirm linearity and precision of the quantitative LC method, accuracy and precision of volume and temperature measurements and negligible vessel-to-vessel carryover.
authors.affiliation: Parke-Davis Pharmaceutical Research and Development, Warner-Lambert Co. Inc., Morris Plains, NJ 07950.
authors.forename: O T
authors.initials: OT
authors.lastname: Aloba
authors.forename: D E
authors.initials: DE
authors.lastname: Bergman
authors.forename: R T
authors.initials: RT
authors.lastname: Miller
authors.forename: R E
authors.initials: RE
authors.lastname: Daly
mesh_terms: D002214:Capsules / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D002851:Chromatography, High Pressure Liquid; D004867:Equipment Design; D017022:Flow Injection Analysis; D015203:Reproducibility of Results; D012371:Robotics / Q000295:instrumentation*; D012984:Software; D013607:Tablets / Q000737:chemistry
chemical_list: D002214:Capsules; D013607:Tablets