Characterization of responders and nonresponders to tiaprofenic acid and naproxen in the treatment of patients with osteoarthritis.
OBJECTIVE
To characterize responders/nonresponders to 2 nonsteroidal antiinflammatory drugs by a combination of start variables in the treatment of patients with osteoarthritis (OA) of the hip(s)/knee(s).


METHODS
Two hundred eight patients participated in a 3-week randomized double blind parallel group trial.


RESULTS
The responder rate to tiaprofenic acid and naproxen was 52 and 59%, respectively. Correctly characterized by use of a combination of 6 baseline variables were 79% of the patients treated with tiaprofenic acid and 81% treated with naproxen.


CONCLUSIONS
Both active drugs were found effective compared with placebo in patients with OA, but with different characteristics.
Høyeraal
H M
HM
Centre of Rheumatology, Haukeland Hospital, University of Bergen, Norway.
Fagertun
H
H
Ingemann-Hansen
T
T
Ersmark
H
H
Rönn
O
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016002:Discriminant Analysis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy*; D011422:Propionates / Q000627:therapeutic use*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid; D009288:Naproxen