title: gamma delta T-cell receptor-positive cells of human skin. II. Appearance in delayed-type hypersensitivity reaction.
abstract: In order to investigate the distribution and involvement of human gamma delta T-cell receptor-positive (TCR+) cells in delayed-type hypersensitivity reactions of the skin, we examined the occurrence and kinetics of gamma delta TCR+ cells during skin reactions of allergic contact dermatitis. In normal human skin sections, gamma delta TCR+ cells were scarce. In allergic contact dermatitis from DNCB, increased gamma delta TCR+ cells were observed both in the epidermis and in the dermis from 48 h after the challenge. Most of the gamma delta TCR+ cells were TCR delta 1+ delta TCS1- BB3+ Ti gamma A+ (V delta 1- V delta 2+ V gamma 9+). The percentage of gamma delta TCR+ cells in the peripheral blood remained unchanged and a few gamma delta TCR+ cells in the skin lesions proliferated in situ. It is suggested that the gamma delta TCR+ cells in skin lesions of allergic contact dermatitis may not be involved in initiation of delayed-type hypersensitivity but may have some other roles responding to factors induced in the reaction.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: S
authors.initials: S
authors.lastname: Imamura
mesh_terms: D017449:Dermatitis, Allergic Contact / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007111:Immunity, Cellular; D007700:Kinetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012867:Skin / Q000737:chemistry*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta