title: Congenital deficiency of factor VII in subarachnoid hemorrhage.
abstract: BACKGROUND
  Factor VII is essential for coagulation activation by the extrinsic pathway. Hemorrhages of the central nervous system in patients with congenital factor VII deficiency seem to have a higher incidence compared with other congenital coagulopathies. The purpose of this paper is to report two rare cases of subarachnoid hemorrhage and factor VII deficiency.
  
  
  METHODS
  Two cases of women affected by a congenital deficiency of factor VII and subarachnoid hemorrhage are reported. Diagnosis was obtained by cerebral computer tomography; cerebral pan-angiography was normal. Complete coagulation studies were performed showing prothrombin time prolongation and factor VII deficiency. In one patient, family studies revealed the existence of a similar coagulation disorder.
  
  
  CONCLUSIONS
  We suggest routine coagulation studies in all patients with subarachnoid hemorrhage. Determination of factor VII activity might be performed in patients with normal activated partial thromboplastin time and prolonged prothrombin time.
authors.affiliation: Department of Haematology, Ospedale Nuovo Pellegrini, Naples, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Papa
authors.forename: G
authors.initials: G
authors.lastname: Schisano
authors.forename: A
authors.initials: A
authors.lastname: Franco
authors.forename: P
authors.initials: P
authors.lastname: Nina
mesh_terms: D000293:Adolescent; D000328:Adult; D001760:Bleeding Time; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis*; D005167:Factor VII / Q000032:analysis*; D005168:Factor VII Deficiency / Q000097:blood* / Q000150:complications*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010375:Pedigree; D010976:Platelet Count; D011517:Prothrombin Time; D012016:Reference Values; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000150:complications*; D013918:Thrombin Time
chemical_list: D001779:Blood Coagulation Factors; D005167:Factor VII; D005340:Fibrinogen