[Spontaneous ecchymosis disclosing acquired factor VIII inhibitor].
An 81-year old woman suddenly developed extensive ecchymosis. A factor VIII:c inhibitor was detected. She received porcine factor VIII, corticosteroids, intravenous immunoglobulins and cyclophosphamide. Normalization of factor VIII level was achieved in 1 month. The patient died, 3 months later, of congestive heart failure. Spontaneous development of factor VIII inhibitors is an extremely rare event which usually occurs in dramatic bleeding. Many associated diseases have been reported. Patients with serious bleeding should be given porcine factor VIII. Immunosuppressive therapy consists of corticosteroids, cyclophosphamide and intravenous immunoglobulins.
Bayrou
O
O
Service de Médecine Interne, Centre d'Allergie, Hôpital Rothschild, Paris.
Deschamps
A
A
Laurian
C
C
Braunstein
C
C
Leynadier
F
F
D000368:Aged; D000369:Aged, 80 and over; D001778:Blood Coagulation Disorders / Q000209:etiology*; D004438:Ecchymosis / Q000209:etiology* / Q000276:immunology; D005130:Eye Hemorrhage / Q000209:etiology*; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000302:isolation & purification; D010314:Partial Thromboplastin Time
D007136:Immunoglobulins; C019158:circulating anticoagulants; D005169:Factor VIII
Ecchymoses spontanées révélatrices d'un inhibiteur acquis du facteur VIII.