title: Effectiveness of holmium laser-assisted coronary angioplasty. The Holmium Laser Coronary Registry.
abstract: The efficacy of holmium laser-assisted angioplasty was studied in 365 narrowings in 331 consecutive patients with coronary artery disease. Clinical indications for study were unstable angina pectoris in 140 patients (42%), stable angina in 136 patients (41%), postmyocardial infarction angina in 35 patients (10.5%), silent myocardial ischemia in 11 patients (3%), acute myocardial infarction in 1 patient (0.3%) and undefined in 8 patients (2%). Coronary morphology characteristics by Multivessel Angioplasty Prognosis Study group criteria were type A in 12.6%, type B1 in 34.2%, type B2 in 27.4% and type C in 25.4%. The laser successfully crossed the total length of the narrowing in 85.2%. Procedural success was 94.2%. Laser alone reduced mean percent luminal narrowing from 88 +/- 11% to 57 +/- 22%. Subsequent balloon angioplasty further reduced the mean luminal narrowing to 23 +/- 18%. Major complication rate was 2.7% (death 0.3%, Q-wave myocardial infarction 0.5%, and emergent bypass surgery 2.7%). Six-month angiographic restenosis (> 50% stenosis) rate was 44%.
authors.affiliation: Department of Medicine, University of Miami/Jackson Memorial Medical Center, Florida.
authors.forename: E J
authors.initials: EJ
authors.lastname: de Marchena
authors.forename: S M
authors.initials: SM
authors.lastname: Mallon
authors.forename: W D
authors.initials: WD
authors.lastname: Knopf
authors.forename: K
authors.initials: K
authors.lastname: Parr
authors.forename: J W
authors.initials: JW
authors.lastname: Moses
authors.forename: D
authors.initials: D
authors.lastname: Murphy-Chutorian
authors.forename: R J
authors.initials: RJ
authors.lastname: Myerburg
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D017222:Angioplasty, Balloon, Laser-Assisted / Q000009:adverse effects; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D005260:Female; D006695:Holmium; D006801:Humans; D008297:Male; D011859:Radiography; D012008:Recurrence; D012042:Registries; D016896:Treatment Outcome
chemical_list: D006695:Holmium