title: Diagnosis and fluoxetine treatment of compulsive behavior disorder of adults with mental retardation.
abstract: A set of research diagnostic criteria was developed to identify potential obsessive-compulsive disorders among individuals with mental retardation and aberrant behaviors. The behavior disorders of 10 subjects who met criteria for compulsive behavior disorder and 6 subjects who did not (comparison subjects) were treated using the medication fluoxetine. All subjects were evaluated using an A-B open-trial method with 4-month baseline and treatment phases. Seven of the 10 subjects with compulsive behavior disorder responded favorably to fluoxetine treatment; none of the comparison subjects responded favorably to this medication. Further, there appeared to be a relation between manifest motor stereotypies, compulsive behaviors, and response to fluoxetine.
authors.affiliation: Psychology Department, Western Carolina Center, Morganton, NC 28655.
authors.forename: J W
authors.initials: JW
authors.lastname: Bodfish
authors.forename: J T
authors.initials: JT
authors.lastname: Madison
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D016728:Self-Injurious Behavior / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D013239:Stereotyped Behavior / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine