title: Current management of hemophilia B.
abstract: The management of hemorrhagic episodes in patients with hemophilia B is in transition as a result of the availability of new products for replacement therapy. Although the basic principles of therapy have not changed, the new highly purified Factor IX concentrates, AlphaNine and Mononine, represent a break-through, as they appear to be safe in terms of viral transmission and thromboembolic side-effects. These products are now widely available, and although expensive, are regarded by some physicians as the preferred therapy for Hemophilia B. Less pure and less expensive Factor IX products, however, are also available and can be used safely in previously treated patients who have already been exposed to the hepatitis viruses.
authors.affiliation: Department of Medicine, University of North Carolina at Chapel Hill.
authors.forename: H R
authors.initials: HR
authors.lastname: Roberts
authors.forename: M E
authors.initials: ME
authors.lastname: Eberst
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005164:Factor IX / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D015658:HIV Infections / Q000209:etiology; D002836:Hemophilia B / Q000150:complications / Q000188:drug therapy*; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D013923:Thromboembolism / Q000209:etiology
chemical_list: D007518:Isoantibodies; D005164:Factor IX