Effect of 8 wk of bicycle training on the immune system of patients with rheumatoid arthritis.
The effect of 8 wk of progressive bicycle training on the immune system was evaluated in a controlled study on 18 patients with rheumatoid arthritis and moderate disease activity. Maximal O2 uptake increased significantly, whereas heart rate at stage 2 and rate of perceived exertion decreased significantly, in the training group compared with the controls. Resting levels of a number of immune parameters were measured before and after 4 and 8 wk of training. Training did not induce changes in blood mononuclear cell subpopulations, proliferative response, or natural killer cell activity. Furthermore the plasma concentrations of interleukin-1 alpha, interleukin-1 beta, and interleukin-6 did not change in response to training. It is concluded that 8 wk of bicycle training does not influence the immune system of patients with rheumatoid arthritis.
Baslund
B
B
Department of Medicine TTA, Rigshospitalet, Copenhagen, Denmark.
Lyngberg
K
K
Andersen
V
V
Halkjaer Kristensen
J
J
Hansen
M
M
Klokker
M
M
Pedersen
B K
BK
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D001642:Bicycling; D002097:C-Reactive Protein / Q000378:metabolism; D004906:Erythrocyte Count; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007378:Interleukins / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010806:Physical Education and Training; D010835:Phytohemagglutinins / Q000494:pharmacology
D007378:Interleukins; D010835:Phytohemagglutinins; D002097:C-Reactive Protein