Indomethacin for prevention of heterotopic ossification. A randomized controlled study in 41 hip arthroplasties.
The effect of indomethacin 25 mg 3 times daily during the first 2 postoperative weeks in preventing heterotopic bone formation after cemented total hip arthroplasty was investigated in a randomized, double-blind and placebo-controlled clinical trial on 57 patients. 16 patients were secondarily excluded, leaving 19 patients in the indomethacin group and 22 patients in the placebo group. Evaluated from the 3-month radiographs, 18/19 indomethacin patients developed either no or only the milder Grade 1 ossification. In contrast, 11/22 placebo patients developed Grade 2 or 3 ossifications. Our observations favor indomethacin prophylaxis for 2 weeks in cemented arthroplasty of the hip.
Kjaersgaard-Andersen
P
P
Orthopedic Hospital, University of Aarhus, Denmark.
Nafei
A
A
Teichert
G
G
Kristensen
O
O
Schmidt
S A
SA
Keller
J
J
Lucht
U
U
D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control
D007213:Indomethacin