[Grafting of autogenous jugular vein and glutaraldehyde-stabilized human umbilical vein in dogs].
The glutaraldehyde-stabilized human umbilical cord vein (HUV) was implanted to the intrarenal aorta in dogs, by using autogenous jugular vein (AJV) as control. The healing mechanism was shown by angiography, radioisotope scanning Doppler ultrasound, LM, SEM and TEM. The patency rate in 6 months was 95.2% in AJV and 87.5% in HUV. No significant difference was noted between the two veins (P > 0.05). Pathohistological study of AJV and HUV after implantation showed that there were three stages: acute injury, acute inflammatory reaction and hyperplastic repairing of tissues. The new endothelial cells of AJV grew earlier and faster than those of HUV. But, both veins were endothelialized 6 months after operation. The subendothelium of new intima consisted of fibroblasts and collagen fibres less myointimal cells derived from smooth muscle cells in the media. The media and the adventilized were replaced by fibrous connective tissue. HUV stabilized with 0.5% glutaraldehyde for grafting caused no immunologic rejection, and had the structure of the venous wall and antithrombotic function, keeping the grafts patent.
Xu
K
K
Department of Applied Anatomy and Surgery, Third Military Medical University, Chongqing.
Chen
W
W
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery*; D004285:Dogs; D005260:Female; D005976:Glutaral; D006084:Graft Rejection; D006801:Humans; D007601:Jugular Veins / Q000637:transplantation*; D008297:Male; D014471:Umbilical Veins / Q000637:transplantation*; D014654:Vascular Patency
D005976:Glutaral