Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest.
A prospective, randomized, double-blind trial assigned 11 patients to receive coenzyme Q10 and 11 to receive none. Patients pretreated with coenzyme Q10 had a lower left atrial pressure and a lesser incidence of low cardiac output. They also had a wider pulse pressure. The right and left ventricular myocardial ultrastructure was better preserved in patients receiving preoperative treatment with coenzyme Q10. There was no demonstrable benefit to the atrial myocardium.
Chen
Y F
YF
Department of Surgery, Kaohsiung Medical College, Taiwan.
Lin
Y T
YT
Wu
S C
SC
D000328:Adult; D006348:Cardiac Surgical Procedures; D003067:Coenzymes; D004311:Double-Blind Method; D005260:Female; D006324:Heart Arrest, Induced; D006439:Hemodynamics; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000648:ultrastructure*; D011300:Preoperative Care; D011446:Prospective Studies; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10