title: The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.
authors.affiliation: Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
authors.forename: P D
authors.initials: PD
authors.lastname: Stein
authors.forename: J T
authors.initials: JT
authors.lastname: Hunt
authors.forename: D M
authors.initials: DM
authors.lastname: Floyd
authors.forename: S
authors.initials: S
authors.lastname: Moreland
authors.forename: K E
authors.initials: KE
authors.lastname: Dickinson
authors.forename: C
authors.initials: C
authors.lastname: Mitchell
authors.forename: E C
authors.initials: EC
authors.lastname: Liu
authors.forename: M L
authors.initials: ML
authors.lastname: Webb
authors.forename: N
authors.initials: N
authors.lastname: Murugesan
authors.forename: J
authors.initials: J
authors.lastname: Dickey
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D002460:Cell Line; D003619:Dansyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000959:Antihypertensive Agents; D003619:Dansyl Compounds; D065128:Endothelin Receptor Antagonists; D016232:Endothelins; C085754:5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide