Spontaneous factor VIII inhibitor occurring in association with chronic graft-versus-host disease.
The development of spontaneously acquired Factor VIII inhibitors is rare and may lead to serious hemorrhagic sequelae. We report here the case of a patient who acquired a Factor VIII inhibitor two years after an allogeneic bone marrow transplant for CML. This occurred in association with a flare of chronic graft versus host disease (GVDH). He responded to corticosteroid therapy. A review of autoimmune phenomena associated with chronic GVDH and the treatment of Factor VIII inhibitors is discussed.
Seidler
C W
CW
Norris Cotton Cancer Center, Lebanon, New Hampshire 03756.
Mills
L E
LE
Flowers
M E
ME
Sullivan
K M
KM
D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000209:etiology; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002908:Chronic Disease; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006086:Graft vs Host Disease / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male
D005169:Factor VIII