Growth regulation of a T-cell lymphoma via the T-cell receptor.
Autocrine stimulation is described for a Radiation leukaemia virus (RadLV)-induced T-cell lymphoma, C6VL/1. The proliferation of this tumour cell line can be regulated by several agents, including interleukin-2 (IL-2), antibodies to the IL-2 receptor and the T-cell antigen-specific receptor (TCR), as well as RadLV retrovirus particles produced by the cell itself. This information has been gained using various procedures to slow or arrest C6VL/1 proliferation, including the addition of gamma interferon (gamma-IFN) and cell culture at low density. All data suggest that these cells can receive growth stimulation via the T-cell receptor (TCR) and IL-2 receptor, implicating autocrine stimulation of growth involving IL-2 and retroviral gene products.
O'Neill
H C
HC
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra.
D000818:Animals; D002455:Cell Division; D007371:Interferon-gamma / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D016399:Lymphoma, T-Cell / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D016721:Radiation Leukemia Virus / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism / Q000502:physiology*; D015375:Receptors, Interleukin-2 / Q000502:physiology; D012192:Retroviridae Infections / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D014412:Tumor Virus Infections / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D014771:Virion / Q000502:physiology
D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma