Multivariate influence of polyinositols on IP3 in diaphragm: individually applied matrix and vectorial analysis of trauma from small and large body surface area burn groups.
In this report, we have used multivariate and vectorial analyses to aid in understanding perturbations in diaphragmatic signal transduction in consequence to burn trauma. This trauma results from shock emanating from skin scald burn. Its respiratory complications are well-known. Relational matrices derived from experimental animal groups of varying body surface area (% BSA) burn size were subjected to individual multiple linear regression and vectorial analyses. Such individual matrices tested the simultaneous dependency of inositol 1,4,5-triphosphate (IP3) on inositol 1,4-biphosphate (I1,4P2), inositol 1-phosphate (I1P) and inositol. Understanding the contribution of multiple independent parameters simultaneously co-governing the dependency of IP3 offers new insight in regulating signal transduction mechanisms under the duress of burn trauma.
Tomera
J F
JF
Clinical Pharmacology Laboratory, Shriners Burns Institute, Boston, MA.
Lilford
K
K
D000704:Analysis of Variance; D000818:Animals; D001830:Body Surface Area; D002056:Burns / Q000378:metabolism*; D003964:Diaphragm / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D007294:Inositol / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D007295:Inositol Phosphates / Q000378:metabolism*; D008297:Male; D051379:Mice; D015999:Multivariate Analysis; D009824:Ointments; D011108:Polymers; D012044:Regression Analysis; D015398:Signal Transduction / Q000187:drug effects; D012837:Silver Sulfadiazine / Q000494:pharmacology
D007295:Inositol Phosphates; D009824:Ointments; D011108:Polymers; C002647:inositol 1-phosphate; C044259:inositol 1,4-bis(phosphate); D007294:Inositol; D015544:Inositol 1,4,5-Trisphosphate; D012837:Silver Sulfadiazine