title: High-dose oxytocin: 20- versus 40-minute dosage interval.
abstract: OBJECTIVE
  To determine whether an increase in the oxytocin dosing interval would decrease the incidence of uterine hyperstimulation.
  
  
  METHODS
  This study included 1801 consecutive pregnancies receiving high-dose oxytocin. Oxytocin was used for labor augmentation in 1167 and induction in 634 women. Twenty- and 40-minute dosage intervals were compared. The study period was based on an 80% likelihood of detecting 5 and 10% differences in the cesarean and hyperstimulation rates, respectively. Statistics were analyzed with chi 2, Fisher, and Wilcoxon rank-sum tests where appropriate. Multivariate logistic regression and analysis of covariance were used to control for confounding demographic variables.
  
  
  RESULTS
  Comparison of the 20- and 40-minute regimens for labor induction yielded no differences in the rates of cesarean delivery for dystocia (16 versus 19%) or fetal distress (5 versus 6%). The 20-minute regimen for augmentation was associated with a significant reduction in cesarean for dystocia (8 versus 12%; P = .05). The incidence of uterine hyperstimulation was greater with the 20-minute than the 40-minute regimen for induction (40 versus 31%; P = .02), but not for augmentation (31 versus 28%). Neonatal outcomes were unaffected by the dosage interval for both augmentation and induction.
  
  
  CONCLUSIONS
  A 40-minute dosing interval for high-dose oxytocin offers no clear advantage over a 20-minute interval. Both regimens were safe and efficient, with no differences in perinatal outcome. The 20-minute interval was associated with fewer cesareans for dystocia when used for labor augmentation, whereas the 40-minute interval resulted in less hyperstimulation when used for labor induction.
authors.affiliation: Department of Obstetrics and Gynecology, Wilford Hall United States Air Force Medical Center, Lackland AFB, Texas.
authors.forename: A J
authors.initials: AJ
authors.lastname: Satin
authors.forename: K J
authors.initials: KJ
authors.lastname: Leveno
authors.forename: M L
authors.initials: ML
authors.lastname: Sherman
authors.forename: D
authors.initials: D
authors.lastname: McIntire
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D004334:Drug Administration Schedule; D004420:Dystocia / Q000453:epidemiology / Q000601:surgery; D005260:Female; D006801:Humans; D007751:Labor, Induced; D015999:Multivariate Analysis; D016017:Odds Ratio; D010121:Oxytocin / Q000008:administration & dosage*; D011247:Pregnancy; D013997:Time Factors
chemical_list: D010121:Oxytocin