[Post-irradiation changes of metabolic and functional activity of adhesive macrophages].
Research into dose- and time-dependent alterations of quantitative and qualitative composition of the peritoneal cells has been carried out. Exposure at 3, 5, 7, or 9 Gy reduced the total number of peritoneal cells, increased the activity of the lactate-, malate-, and qlucoso-6-phosphate dehydrogenases, of the acid phosphatase and catepsin D; the amount of the cell protein in adhesing macrophages was also increased. The exposed macrophages showed enhanced phagocytic and cytotoxic activity as evidenced by the increase in luminol- and lucigenin-enhanced chemilumenscence in vitro. The most pronounced changes took place 7-9 days after exposure at 9 Gy.
Khlopovskaia
E I
EI
Budagov
R S
RS
Chureeva
L N
LN
D000135:Acid Phosphatase / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D002402:Cathepsin D / Q000378:metabolism / Q000528:radiation effects; D002448:Cell Adhesion / Q000528:radiation effects; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism / Q000528:radiation effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism / Q000528:radiation effects; D008163:Luminescent Measurements; D017737:Macrophages, Peritoneal / Q000378:metabolism* / Q000528:radiation effects*; D008291:Malate Dehydrogenase / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D013997:Time Factors
D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000135:Acid Phosphatase; D002402:Cathepsin D
Postradiatsionnye izmeneniia metabolicheskoĭ i funktsionalńoĭ aktivnosti adgeziruiushchikh makrofagov.