Fungal metabolites. IX. Synthesis of a membrane-modifying peptide, hypelcin A-III, from Hypocrea peltata.
A membrane-modifying peptide antibiotic having uncoupling activity on rat liver mitochondria, hypelcin A-III, has been synthesized by assembling five peptide fragments via the N,N'-dicyclohexylcarbodiimide method. The synthesized hypelcin A-III was identical with the natural product.
Matsuura
K
K
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Yesilada
A
A
Iida
A
A
Nagaoka
Y
Y
Takaishi
Y
Y
Fujita
T
T
D000408:Alamethicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000595:Amino Acid Sequence; D006999:Hypocreales / Q000378:metabolism*; D008969:Molecular Sequence Data
D000408:Alamethicin; C025478:hypelcin A