title: Serotonergic sensitivity in borderline personality disorder: preliminary findings.
abstract: Twelve patients with borderline personality disorder and 15 healthy comparison subjects were challenged with single doses of oral m-chlorophenylpiperazine (m-CPP) and placebo. Following m-CPP, the patients experienced decreased anger and fear. Seven of the 12 patients reported a "spacy," "high," depersonalized/derealized experience following m-CPP, which was confirmed by clinicians' ratings. Compared with the normal male subjects, the male patients with borderline personality disorder had higher cortisol levels and marginally blunted prolactin responses after receiving m-CPP. These results suggest serotonergic dysfunction in borderline personality disorder.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York.
authors.forename: E
authors.initials: E
authors.lastname: Hollander
authors.forename: D J
authors.initials: DJ
authors.lastname: Stein
authors.forename: C M
authors.initials: CM
authors.lastname: DeCaria
authors.forename: L
authors.initials: L
authors.lastname: Cohen
authors.forename: J B
authors.initials: JB
authors.lastname: Saoud
authors.forename: A E
authors.initials: AE
authors.lastname: Skodol
authors.forename: D
authors.initials: D
authors.lastname: Kellman
authors.forename: L
authors.initials: L
authors.lastname: Rosnick
authors.forename: J M
authors.initials: JM
authors.lastname: Oldham
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000786:Anger / Q000187:drug effects; D001883:Borderline Personality Disorder / Q000175:diagnosis* / Q000503:physiopathology; D003861:Depersonalization / Q000139:chemically induced; D005239:Fear / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology; D010919:Placebos; D011388:Prolactin / Q000097:blood; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*
chemical_list: D010879:Piperazines; D010919:Placebos; D011985:Receptors, Serotonin; D012701:Serotonin; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine