Dauricoside, a new glycosidal alkaloid having an inhibitory activity against blood-platelet aggregation.
Dauricoside (1), a new glycosidal alkaloid, was isolated from the rhizomes of Menispermum dauricum DC. along with dauricine (2), daurisoline (3), dauriporphine (4), menisporphine (5), and 6-O-demethylmenisporphine (6), and its structure was determined by means of spectroscopic methods. Compounds 1, 2, and 3 inhibited blood-platelet aggregation induced by adenosine 5'-diphosphate (ADP).
Hu
S M
SM
Shenyang College of Pharmacy, China.
Xu
S X
SX
Yao
X S
XS
Cui
C B
CB
Tezuka
Y
Y
Kikuchi
T
T
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides; D010975:Platelet Aggregation Inhibitors; C085280:dauricoside