title: Evaluation of the pulsatility of a new pulsatile left ventricular assist device--the integrated cardioassist catheter--in dogs.
abstract: A new pulsatile left ventricle-femoral artery bypass system (integrated cardioassist catheter system) has been developed for rapid, percutaneous insertion as a left ventricular assist device. Previous experiments revealed its superiority over the intraaortic balloon pump system in maintaining the peripheral circulation and in improving myocardial blood flow and afterload. Our objective was to determine whether the pulsatility of left ventricular bypass of this system would be preferable for maintaining the peripheral circulation and managing the ischemic myocardium as compared with nonpulsatile left ventricular bypass. Ten dogs with profound heart failure were supported by this system. Their hemodynamic status and myocardial blood flow were measured under control, nonpulsatile left ventricular bypass, or synchronous pulsatile left ventricular bypass. Significant differences between the nonpulsatile bypass group and the pulsatile bypass group were observed in the mean increase in aortic pressure (3.5% versus 22.2%, respectively; p < 0.001), total cardiac output (13.0% versus 21.7%; p = 0.004), and myocardial blood flow (9.5% versus 21.8%; p < 0.001). No differences were found between groups in the decrease in left atrial pressure (-20.2% versus -20.2%; p > 0.05). The ratio of diastolic time index/tension time index was shown to be improved significantly in the pulsatile bypass group compared with that of control and nonpulsatile bypass groups (p < 0.001). Thus, the pulsatility of the integrated cardioassist catheter system may support the peripheral circulation and improve the myocardial blood flow and oxygen supply/demand ratio.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Kyorin Medical School, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ide
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Ino
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: A
authors.initials: A
authors.lastname: Mizuhara
authors.forename: K
authors.initials: K
authors.lastname: Kawahito
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: I
authors.initials: I
authors.lastname: Fujimasa
mesh_terms: D000818:Animals; D001775:Blood Circulation; D006328:Cardiac Catheterization; D004285:Dogs; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006353:Heart-Assist Devices; D006439:Hemodynamics; D007423:Intra-Aortic Balloon Pumping; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D011673:Pulsatile Flow