Rapidly progressive glomerulonephritis (RPGN): is there still an "idiopathic" subgroup?
In order to clarify if "idiopathic" RPGN still exists as a distinct entity we reviewed 41 patients with histological picture of diffuse crescentic GN (60% of crescents) and no clinical evidence of systemic disease. According to the presence or absence of intraglomerular necrotizing lesions we subdivided the patients into two different morphological groups: Group I (25 pts) with necrotizing GN and massive periglomerular infiltrates; Group II (16 pts) with intra-extracapillary proliferation and no interstitial infiltrates. Our data suggest that "idiopathic" RPGN does not exist as a distinct entity, but is an expression either of renal limited vasculitis or crescentic GN complicating primary proliferative GN.
Ferrario
F
F
Division of Nephrology, San Carlo Hospital, Milano, Italy.
Tadros
M
M
Napodano
P
P
Giordano
A
A
Sinico
R A
RA
Fellin
G
G
D'Amico
G
G
D002196:Capillaries / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000473:pathology; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D009336:Necrosis; D012189:Retrospective Studies
D003176:Complement C3; D005340:Fibrinogen