Coxiella burnetii infection among subjects infected with HIV type 1 in the Central African Republic.
Sixty-six sera from HIV-1-seropositive adult African subjects and 49 sera from HIV-seronegative age and sex matched healthy African controls living in Bangui, Central African Republic, were screened for Coxiella burnetii antibody by an indirect immunofluorescent antibody test. 16.7% of HIV-infected patients and 16.3% of the HIV-negative controls had positive IgG titres, with no significant difference between the two groups. Two of the seven HIV-infected patients seropositive for Coxiella burnetii for whom clinical data was available had a medical history compatible with symptomatic Q fever. These findings indicate that there is a high degree of exposure to Coxiella burnetii infection in Bangui. In individuals co-infected with HIV and Coxiella burnetii, cellular immunosuppression could favour symptomatic Q fever. Physicians should be aware of the possibility of symptomatic Coxiella burnetii infection among HIV-infected people, particularly in endemic regions for both infections such as in sub-saharan Africa.
Bélec
L
L
Laboratoire de Microbiologie, Hôpital Broussais, Paris, France.
Grésenguet
G
G
Ekala
M T
MT
Jacob
A
A
Vohito
M D
MD
Cotigny
S
S
Payan
C
C
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology*; D000328:Adult; D000350:Africa, Central / Q000453:epidemiology; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D015995:Prevalence; D011778:Q Fever / Q000453:epidemiology*