title: Immunoglobulin-secreting cells in primary immunodeficiency diseases.
abstract: To assess immunoglobulin production in vivo, the numbers of immunoglobulin-secreting cells were measured in uncultured peripheral blood mononuclear cells (PBMCs) of patients with primary immunoglobulin deficiency. The numbers of immunoglobulin-secreting cells were found to be variable, and they were well correlated with the serum concentrations of all three major immunoglobulin classes. Our results suggest that measurement of immunoglobulin-secreting cells in PBMCs is useful in the assessment of the ability to produce immunoglobulin in vivo.
authors.affiliation: Department of Pediatrics, Gifu University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: S
authors.initials: S
authors.lastname: Shinoda
authors.forename: G P
authors.initials: GP
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Orii
mesh_terms: D000921:Antibody-Producing Cells; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*
chemical_list: D007136:Immunoglobulins