Conservation and reiteration of a kinase cascade.
A cascade of three protein kinases has emerged as a conserved functional module in a wide variety of signal transduction pathways in diverse organisms. In addition to this evolutionary conservation, studies in yeast demonstrate that versions of this module are used in different signalling pathways. Thus, homologous kinase cascades function in response to different stimuli in the same cell.
Neiman
A M
AM
Department of Biochemistry and Biophysics, University of California at San Francisco 94143-0448.
D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000502:physiology; D004330:Drosophila / Q000502:physiology; D005800:Genes, Fungal / Q000502:physiology; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D012568:Schizosaccharomyces / Q000201:enzymology / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology*; D014981:Xenopus / Q000502:physiology
D011494:Protein Kinases