Concomitant administration of MK-801 and desipramine enhances extracellular concentration of dopamine in the rat prefrontal cortex.
The interaction between the antidepressant drug desipramine and the non-competitive NMDA receptor antagonist MK-801 was investigated at the level of dopamine release in the rat prefrontal cortex. Peripheral administration of MK-801 (0.2 mg kg-1) or desipramine (10 mg kg-1) evoked weak enhancement of the extracellular dopamine concentration in the rat PFC. Desipramine and MK-801 given jointly in doses which by themselves evoked a mild alteration of dopamine outflow (10 mg and 0.2 mg kg-1 respectively) produced pronounced enhancement of the extracellular concentration of dopamine in the rat prefrontal cortex. It is suggested that the non-competitive NMDA receptor antagonist may enhance the efficacy of classical antidepressant drugs.
Wedzony
K
K
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Gołembiowska
K
K
D000818:Animals; D003891:Desipramine / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004347:Drug Interactions; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008297:Male; D017551:Microdialysis; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D016291:Dizocilpine Maleate; D003891:Desipramine