Effect of toxins 544 and 514 from Karwinskia humboldtiana (buckthorn) plant upon fetal development of the mouse.
The teratogenic effect of toxins 544 and 514 from K. humboldtiana upon the mouse embryo was evaluated. One half of the LD50 dose for the mouse was administered at day 8 of gestation. At the end of pregnancy, reproduction and fetal data were recorded. Dams treated with toxin 544, but not with toxin 514, showed a higher incidence of reabsorptions, malformations, as well as lower fetal length compared to the control group.
Valadez-Alvizo
R
R
Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo Leoń, Monterrey, Mexico.
Rodríguez-Alvarado
A
A
Martínez de Villarreal
L
L
González-Alanís
R
R
Piñeyro-López
A
A
D000818:Animals; D000873:Anthracenes / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011714:Pyrans / Q000633:toxicity*; D031955:Rhamnus / Q000737:chemistry*; D013723:Teratogens / Q000633:toxicity*; D014118:Toxins, Biological / Q000633:toxicity*
D000873:Anthracenes; D011714:Pyrans; D013723:Teratogens; D014118:Toxins, Biological; C075149:Karwinskia toxin T-514; C075148:Karwinskia toxin T-544