Anti-inflammatory activity of the essential oil of Bupleurum fruticescens.
The essential oil of Bupleurum fruticescens was investigated qualitatively and quantitatively by GC and GC-MS analyses. The anti-inflammatory activity of the whole essential oil and its major components was also investigated in the rat hindpaw edema model induced by carrageenin or by PGE1. The anti-inflammatory activity shown by the essential oil can be attributed to the two major components, alpha-pinene and beta-caryophyllene. In order to know the role of the adrenal glands in the anti-inflammatory activity exerted by the two major components of the essential oil, they were studied against the carrageenin-induced hindpaw edema in adrenolectomized rats. It is concluded that alpha-pinene needs the integrity of the adrenal glands to exert its anti-inflammatory activity, as opposed to beta-caryophyllene which was also active in adrenolectomized animals.
Martin
S
S
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, Spain.
Padilla
E
E
Ocete
M A
MA
Galvez
J
J
Jiménez
J
J
Zarzuelo
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D009822:Oils, Volatile / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009822:Oils, Volatile; D010938:Plant Oils