title: An immuno-dominant sequential epitope recognized by mouse anti-recombinant bovine growth hormone antisera.
abstract: The sequential epitopes on bovine growth hormone (bGH) recognised by five polyclonal mouse antisera have been identified by scanning with multiple pin-bound peptides. Four main epitopes were identified at residues 29-40, 101-110, 139-152 and 181-191. Of these, only epitope 139-152 is recognised by all five mouse antisera indicating that, for the mouse, this may represent an immuno-dominant region of the bGH molecule.
authors.affiliation: Hannah Research Institute, Ayr, Scotland, UK.
authors.forename: J
authors.initials: J
authors.lastname: Beattie
authors.forename: V
authors.initials: V
authors.lastname: Borromeo
authors.forename: H A
authors.initials: HA
authors.lastname: Fawcett
authors.forename: C
authors.initials: C
authors.lastname: Secchi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D013006:Growth Hormone / Q000276:immunology*; D016056:Immunodominant Epitopes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology
chemical_list: D016056:Immunodominant Epitopes; D010446:Peptide Fragments; D011994:Recombinant Proteins; D013006:Growth Hormone