A surgical approach to chronic aortomyoplasty in the goat model.
The left latissimus dorsi skeletal muscle of seven male goats was prepared and applied circumferentially to the descending aorta just below the subclavian artery. Stimulation of the neural pedicle of the latissimus dorsi was performed in an attempt to convert it to a fatigue-resistant cardiac-like muscle. Timing of the stimulus was in diastole. Biochemical assays established the conversion, and echocardiography demonstrated aortic compressions in the area of the muscle wrap. Although limited in numbers, the converted latissimus dorsi muscle in the extra-aortic position appears to provide diastolic augmentation.
Vertrees
R A
RA
Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden.
Cernaianu
A C
AC
Camishion
R C
RC
Cilley
J H
JH
Baldino
W A
WA
DelRossi
A J
AJ
D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D006041:Goats; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000637:transplantation*; D013997:Time Factors