Comparative study of the antitumor activity of bistramides A, D and K against a non-small cell broncho-pulmonary carcinoma.
Bistramides A, D and K are substances extracted from the marine ascidian Lissoclinum bistratum Sluiter that are capable of inducing in vitro terminal differentiation (G1DT) of cells from a non-small cell broncho-pulmonary carcinoma (NSCLCN6), but present different in vitro toxicities. This study shows that only the least toxic bistramides D and K possess an antitumor activity. These two substances could be administered as a continuous treatment which would induce terminal differentiation of stem cells at their entry into the cell cycle, thereby causing their destruction.
Riou
D
D
SMAB (Substances Marines à Activité Biologique, Nantes, France.
Roussakis
C
C
Biard
J F
JF
Verbist
J F
JF
D000081:Acetamides; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D015394:Molecular Structure; D011714:Pyrans; D012044:Regression Analysis; D013141:Spiro Compounds; D013329:Structure-Activity Relationship; D014183:Transplantation, Heterologous
D000081:Acetamides; D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D011714:Pyrans; D013141:Spiro Compounds; C059975:bistratene A; C085520:bistramide D; C085521:bistramide K