title: Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration.
abstract: The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12 +/- 0.01 h and 1.94 +/- 0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2 +/- 0.01 L/kg and 92.9 +/- 3.69 ml/kg/h, respectively. About 74% of the administered dose was excreted in urine in 24 h. A suitable dosage regimen for the intravenous administration of kanamycin was also calculated.
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
authors.forename: S
authors.initials: S
authors.lastname: Rampal
authors.forename: A K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: R K
authors.initials: RK
authors.lastname: Chaudhary
mesh_terms: D000818:Animals; D002020:Buffaloes / Q000378:metabolism*; D004334:Drug Administration Schedule / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007612:Kanamycin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D016018:Least-Squares Analysis; D008657:Metabolic Clearance Rate; D014018:Tissue Distribution
chemical_list: D007612:Kanamycin