Beta camera low activity tumor imaging.
A new technique, the beta camera, to complement film autoradiography, with fast quantitative imaging of beta particle-emitting radionuclides has been developed. It consists of a thin plastic scintillator and a light-sensitive microchannel plate detector. The thin tissue sample is mounted on the scintillator. Our first system had a high background and a moderate spatial resolution of 900 microns. We now report an improved system with a photomultiplier tube mounted on the scintillator of the microchannel plate detector. Only events registered by both detectors are accepted. A fast coincidence unit processes the signals, and if a time overlap exists, an event is generated in the beta camera. In the coincidence mode, images with low activity distribution of 201Tl (count rate 1 s-1) in 50 microns-thick slices of a human glioma tumor could be recorded with a spatial resolution of 500 microns.
Ljunggren
K
K
Department of Radiation Physics, Lund University Hospital, Sweden.
Strand
S E
SE
Ceberg
C P
CP
Sjöholm
H
H
Elmqvist
D
D
Brun
A
A
Salford
L G
LG
D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D015902:Gamma Cameras; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008961:Models, Structural; D011877:Radionuclide Imaging / Q000295:instrumentation; D012588:Scintillation Counting / Q000295:instrumentation*; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D013794:Thallium Radioisotopes