Kinetic investigation of methotrexate resistant human dihydrofolate reductase (hDHFR) mutants at Phe31.
Chunduru
S K
SK
Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38101.
Appleman
J R
JR
Blakley
R L
RL
D000595:Amino Acid Sequence; D004351:Drug Resistance; D005493:Folic Acid Antagonists; D014644:Genetic Variation; D006801:Humans; D007700:Kinetics; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology*; D016297:Mutagenesis, Site-Directed; D010649:Phenylalanine; D017354:Point Mutation; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics* / Q000378:metabolism
D005493:Folic Acid Antagonists; D011994:Recombinant Proteins; D010649:Phenylalanine; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate