[Study on cisplatin albumin microspheres for neck external artery embolization].
In this paper the technique of emulsion chemical-crosslinking was used to prepare cisplatin albumin microsphere for jaw squamous cancer by neck external artery embolization. It was yellow powder with yield 80 +/- 5%, mean size 56.3 microns, cisplatin concentration 14.02-14.20%, loading rate 97.08-97.95%. The release characteristics in vitro, sterilization, stability and recipe of disperse solvent of cisplatin albumin microsphere were investigated. Animal test showed that cisplatin albumin microsphere may plug the branches of neck external artery well and remain in local tissue.
Cheng
Y H
YH
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Li
L
L
Fu
F H
FH
Liu
Y Y
YY
Liao
G T
GT
Hou
S X
SX
Wen
Y M
YM
D000818:Animals; D002342:Carotid Artery, External; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers; D016503:Drug Delivery Systems; D007573:Jaw Neoplasms / Q000378:metabolism / Q000628:therapy*; D008863:Microspheres; D011817:Rabbits; D012710:Serum Albumin, Bovine
D004337:Drug Carriers; D012710:Serum Albumin, Bovine; D002945:Cisplatin