title: Effect of 8 wk of bicycle training on the immune system of patients with rheumatoid arthritis.
abstract: The effect of 8 wk of progressive bicycle training on the immune system was evaluated in a controlled study on 18 patients with rheumatoid arthritis and moderate disease activity. Maximal O2 uptake increased significantly, whereas heart rate at stage 2 and rate of perceived exertion decreased significantly, in the training group compared with the controls. Resting levels of a number of immune parameters were measured before and after 4 and 8 wk of training. Training did not induce changes in blood mononuclear cell subpopulations, proliferative response, or natural killer cell activity. Furthermore the plasma concentrations of interleukin-1 alpha, interleukin-1 beta, and interleukin-6 did not change in response to training. It is concluded that 8 wk of bicycle training does not influence the immune system of patients with rheumatoid arthritis.
authors.affiliation: Department of Medicine TTA, Rigshospitalet, Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Baslund
authors.forename: K
authors.initials: K
authors.lastname: Lyngberg
authors.forename: V
authors.initials: V
authors.lastname: Andersen
authors.forename: J
authors.initials: J
authors.lastname: Halkjaer Kristensen
authors.forename: M
authors.initials: M
authors.lastname: Hansen
authors.forename: M
authors.initials: M
authors.lastname: Klokker
authors.forename: B K
authors.initials: BK
authors.lastname: Pedersen
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D001642:Bicycling; D002097:C-Reactive Protein / Q000378:metabolism; D004906:Erythrocyte Count; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007378:Interleukins / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010806:Physical Education and Training; D010835:Phytohemagglutinins / Q000494:pharmacology
chemical_list: D007378:Interleukins; D010835:Phytohemagglutinins; D002097:C-Reactive Protein