Inhibitory effects of procainamide and probenecid on renal excretion of sultopride enantiomers in rats.
The effects of the coadministration of procainamide and probenecid on the pharmacokinetic behavior of sultopride, an antipsychotic agent, after intravenous administration were studied with rats. The areas under the concentration-time curve for and renal clearances of (+)-sultopride and (-)-sultopride, which exist as organic cations under physiological pH conditions, were significantly decreased (p < 0.01) by the coadministration of procainamide, an organic cation under physiological pH conditions. The renal clearance of (-)-sultopride was partially decreased (p < 0.05) by the coadministration of probenecid, an organic anion under physiological pH conditions. The results suggest that drug-drug interactions between organic cations and organic anions occur to a certain extent during the tubular secretion process in rats.
Kamizono
A
A
Department of Pharmacy, Kumamoto University Hospital, Japan.
Inotsume
N
N
Fukushima
S
S
Nakano
M
M
Okamoto
Y
Y
D000077582:Amisulpride; D000818:Animals; D004347:Drug Interactions; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D011339:Probenecid / Q000494:pharmacology*; D011342:Procainamide / Q000097:blood / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine
D011619:Psychotropic Drugs; D013469:Sulpiride; D000077582:Amisulpride; D011342:Procainamide; D011339:Probenecid