A preliminary study of cortical S2 serotonin receptors and cognitive performance following stroke.
Cortical serotonin receptor binding was measured with positron-emission tomography (PET) in uninjured regions of cortex in 26 stroke patients. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) and a neuropsychological test battery. Left frontal cortex serotonin binding was correlated positively with MMSE total score (r = 0.50, P = 0.01) and with the MMSE concentration, writing, and copying tasks (r = 0.42, 0.56, 0.53, respectively; P < 0.05). Tests of orientation and repetition of difficult phrases were significantly correlated with serotonin binding (r = 0.53 and 0.52, respectively; P < 0.05). These findings suggest that cognitive performance after stroke may be influenced by alterations in the serotonergic system.
Morris
P L
PL
Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia.
Mayberg
H S
HS
Bolla
K
K
Wong
D F
DF
Dannals
R F
RF
Starkstein
S E
SE
Robinson
R G
RG
D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000378:metabolism*
D011985:Receptors, Serotonin