title: The in vitro effects of ceftibuten on the host defense mechanism.
abstract: The in vitro effects of ceftibuten on human polymorphonuclear leukocyte (PMN) chemotaxis, phagocytosis and chemiluminescence were investigated. PMN from healthy adult donors were incubated for 1 h in medium alone or in medium containing increasing concentrations of ceftibuten (4, 8 and 40 times the MIC for Escherichia coli). Up to 40 MIC ceftibuten did not significantly interfere with the function of PMN.
authors.affiliation: Department of Pharmacology, School of Medicine, University of Milan, Italy.
authors.forename: P C
authors.initials: PC
authors.lastname: Braga
authors.forename: G
authors.initials: G
authors.lastname: Piatti
authors.forename: M
authors.initials: M
authors.lastname: Dal Sasso
authors.forename: S
authors.initials: S
authors.lastname: Maci
authors.forename: F
authors.initials: F
authors.lastname: Blasi
mesh_terms: D000328:Adult; D000077722:Ceftibuten; D002511:Cephalosporins / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects*; D016897:Respiratory Burst / Q000187:drug effects
chemical_list: D002511:Cephalosporins; D000077722:Ceftibuten