Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.
Peters
G J
GJ
Dept. Oncology, Free University Hospital, Amsterdam, The Netherlands.
Hoekman
K
K
van Groeningen
C J
CJ
van der Wilt
C L
CL
Smid
K
K
Meijer
S
S
Pinedo
H M
HM
D001665:Binding Sites; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005468:Fluorodeoxyuridylate / Q000378:metabolism; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D002955:Leucovorin / Q000494:pharmacology*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
D005468:Fluorodeoxyuridylate; D013940:Thymidylate Synthase; D002955:Leucovorin; D005472:Fluorouracil