[Consupren in prophylactic therapy after kidney transplantation].
Thirty patients after a first transplantation of the kidney from a dead donor were treated with Consupren Galena combined with azathioprine and prednisone for a period of at least one year. As control served a comparable historical group of 50 patients treated with a combination of three immunosuppressive drugs using Sandimmune, Sandoz. No significant differences were found between the two groups as regards the functional development of the grafts, the number of lost grafts, the cumulative survival of grafts, the number of rejections and the number of deaths. As to undesirable effects there were insignificantly more patients with a nephrotoxic episode in group CS where also repeated nephrotoxic episodes were recorded. The most frequent undesirable effect in group CS was hirsutism in half the patients. Consupren used in prophylactic treatment in combination with a azathioprine and prednisone appears to be a comparable immunosuppressive regime as that which comprises Sandimmune, Sandoz.
Matl
I
I
Jirka
J
J
Petrásek
R
R
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000008:administration & dosage
D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone
Consupren v profylaktické lécbĕ po transplantaci ledviny.