title: Nifedipine induced modulations of intra-thyroidal radio-iodine turnover kinetics in euthyroid and thyrotoxic patients.
abstract: Nifedipine induced modulations of intrathyroidal radioiodine turnover kinetics has been studied in euthyroid and thyrotoxicosis individuals. Nifedipine has been found to suppress Amax significantly (p < 0.001), while transit kinetics k1 and k2 are not significantly affected. On the contrary, in the patients with thyrotoxicosis post-nifedipine Amax was not significantly different from pre-nifedipine study, while k1 was slightly suppressed (p < 0.05) and k2 was significantly elevated (p < 0.01). Apparently different Ca+2 dependent control mechanisms are operative in euthyroid and thyrotoxic states. Clinical implications of these observations have been discussed.
authors.affiliation: Department of Nuclear Medicine, Institute of Medical Sciences, Srinagar.
authors.forename: D R
authors.initials: DR
authors.lastname: Jangid
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D013961:Thyroid Gland / Q000378:metabolism*; D013971:Thyrotoxicosis / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D009543:Nifedipine