title: Noninvasive digital energy subtraction angiography with a channeling-radiation x-ray source.
abstract: Channeling radiation could provide a viable source for digital energy subtraction angiography (DESA). A signal to noise ratio (SNR) of 6.2 for a resolution of 0.5 mm x 0.5 mm could be achieved using a 6-mA 100-ms 20-MeV electron-beam pulse and a diamond channeling crystal as the x-ray source. This article investigates the choice of a DESA contrast agent and the parameters of a channeling-radiation x-ray source to develop a channeling-radiation DESA imaging system. The production of dual-energy peaks, the maximum available x-ray flux, the advantages of an area exposure, the necessity of a mosaic Bragg-crystal filter to reduce patient dose, the optimal energy separation of the peaks for a quasi-monochromatic x-ray source, and the reduction of the signal from bone are discussed, leading to estimated SNRs and image resolution for a channeling-radiation imaging system. The computer analysis developed to calculate the image quality is also discussed.
authors.affiliation: Adelphi Technology, Palo Alto, California 94306.
authors.forename: C K
authors.initials: CK
authors.lastname: Gary
authors.forename: M A
authors.initials: MA
authors.lastname: Piestrup
authors.forename: D G
authors.initials: DG
authors.lastname: Boyers
authors.forename: C I
authors.initials: CI
authors.lastname: Pincus
authors.forename: R H
authors.initials: RH
authors.lastname: Pantell
authors.forename: G B
authors.initials: GB
authors.lastname: Rothbart
mesh_terms: D015901:Angiography, Digital Subtraction / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D003287:Contrast Media; D006801:Humans; D007455:Iodine; D008961:Models, Structural; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D007455:Iodine