title: Genotoxicity of tritiated water in human lymphocytes.
abstract: The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that beta-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE.
authors.affiliation: Departament de Genética i de Microbiologia, Facultat de Ciènces, Universitat Autónoma de Barcelona, Cerdanyola de Vallès, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Ribas
authors.forename: E
authors.initials: E
authors.lastname: Carbonell
authors.forename: N
authors.initials: N
authors.lastname: Xamena
authors.forename: A
authors.initials: A
authors.lastname: Creus
authors.forename: R
authors.initials: R
authors.lastname: Marcos
mesh_terms: D001610:Beta Particles; D002453:Cell Cycle / Q000528:radiation effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D012854:Sister Chromatid Exchange / Q000528:radiation effects*; D014316:Tritium
chemical_list: D014316:Tritium