Effects on behavior of modulation of gonadal function in men with gonadotropin-releasing hormone antagonists.
The effects of acute gonadal suppression on sexual function and behavior were studied in eight normal men. Administration of a newly developed, potent gonadotropin-releasing hormone antagonist induced azoospermia and reduced levels of serum testosterone, luteinizing hormone, and follicle-stimulating hormone. These effects coincided with a reduction in outward-directed aggression in all men. Self-reported measures of anxiety and sexual desire revealed less consistent change over time. Measures of anger control, inward-directed anger, and affective state were unaffected.
Loosen
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Department of Psychiatry, Vanderbilt University, Nashville, TN.
Purdon
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Pavlou
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D000328:Adult; D000374:Aggression / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D007989:Libido / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000139:chemically induced; D012725:Sexual Behavior / Q000187:drug effects*; D013739:Testosterone / Q000097:blood / Q000494:pharmacology
C057805:LHRH, N-Ac-2-Nal(1)-4-Cl-Phe(2)-3-Pal(3)-Arg(5)-Glu(6)-AlaNH2(10)-; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone