Reconstitution of immunological imbalance in SCID mice given tonsillar mononuclear cells from patients with IgA nephropathy.
IgA nephropathy (IgAN) is thought to be mediated by the glomerular deposition of circulating immune complexes containing IgA as the major antibody component. Tonsillitis often precedes IgAN, and tonsillectomy is an efficient treatment of IgAN. Thus, the tonsil may cause initial and/or progressive events leading to IgAN. To determine the pathological features of tonsillar lymphoid cells, we transferred tonsillar mononuclear cells from IgAN patients to SCID mice. Although human IgG-, IgM- and IgA-positive cells were detected in the spleens of SCID-Hu mice, they failed to reproduce the increase in serum IgA level and glomerular deposition. These results suggest that other factors are needed for the progression of IgAN.
Kusakari
C
C
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Takasaka
T
T
D000818:Animals; D017690:Cell Transplantation; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D016513:Mice, SCID; D014066:Palatine Tonsil / Q000276:immunology* / Q000473:pathology; D014068:Tonsillectomy
D007070:Immunoglobulin A; D007074:Immunoglobulin G