Purified FSH as a treatment for a cervical hostility.
Abnormal cervical mucus (CM) quality and quantity is considered one of the causes of infertility which occurs in only 2 to 8 per cent of infertile couples. The periovulatory mucus with its specific properties is necessary to determine a correct Post Coital Test (PCT). Twenty patients, with infertility for over 18 months and with a baseline negative PCT (repeated at least three times) for abnormal CM, were treated with pFSH. Our results show that the pFSH improves the quality and quantity of CM in all for our patients including an improvement of penetration and motility spermatozoa in 55 per cent of our cases. Therefore we suggest the routine pFSH use in case of cervical hostility and recurrent negative PCT.
Nicotra
M
M
II Istituto di Clinica Ostetrica e Ginecologica, Università La Sapienza Roma, Italia.
Muttinelli
C
C
Rolfi
G
G
Amato
P
P
D000328:Adult; D002582:Cervix Mucus / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D002584:Cervix Uteri; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D008297:Male; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects
D005640:Follicle Stimulating Hormone