[Isoprotein composition of alpha 1-antitrypsin, haptoglobin, transferrin, and lipid peroxidation in the blood in inflammatory lung diseases in children].
Relationship was studied between the polymorphism of alpha 1-antitrypsin (Pi), haptoglobin (Hp) and transferrin and the development of chronic unspecific impairment of children lungs. Combination of protein isoforms PiM3M3 and Hp 1-1 was found to increase the risk of the lungs unspecific impairments in persons with lingering pneumonia and caused more severe development of the disease. Relatively low activity of the isoform PiM3M3, as compared with other forms of the PiMM system, and more intensive and nonadequate rate of lipid peroxidation in patients containing HP 1-1 appear to be responsible for aggravation of these impairments.
Mironov
P I
PI
Vakhitov
V A
VA
Davletov
E G
EG
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006242:Haptoglobins / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D011014:Pneumonia / Q000097:blood*; D011110:Polymorphism, Genetic; D014168:Transferrin / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D006242:Haptoglobins; D014168:Transferrin; D000515:alpha 1-Antitrypsin
Izobelkovyĭ sosotav alpha 1-antitripsina, gaptoglobina, transferrina iperekisnoe okislenie lipidov krovi pri vospalitel'nykh zabolevaniiakh legkikh u deteĭ.