title: Lack of influence of aromatase and 5 alpha-reductase inhibition on [3H]imipramine binding in the male rat brain.
abstract: In intact adult male rats an inhibitor of aromatase and an inhibitor of 5 alpha-reductase did not change the characteristics of [3H]imipramine binding sites in cerebral cortex, hypothalamus, and hippocampus. Testosterone, estradiol and dihydrotestosterone prevented the effect of castration on the number of [3H]imipramine binding sites, but had no effect in non-castrated animals. These data suggest that testosterone and its major metabolites, estradiol and dihydrotestosterone, are equally effective with regard to imipramine binding sites.
authors.affiliation: Istituto di Farmacologia, Università di Modena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sandrini
authors.forename: A V
authors.initials: AV
authors.lastname: Vergoni
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000494:pharmacology*; D058891:5-alpha Reductase Inhibitors; D000735:Androstenedione / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001141:Aromatase / Q000494:pharmacology*; D047072:Aromatase Inhibitors; D001378:Azasteroids / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D007099:Imipramine / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D058891:5-alpha Reductase Inhibitors; D047072:Aromatase Inhibitors; D001378:Azasteroids; D012739:Gonadal Steroid Hormones; D013196:Dihydrotestosterone; D000735:Androstenedione; C047523:17-N,N-diisopropylcarbamoyl-4-azaandrostan-3-one; D001141:Aromatase; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D007099:Imipramine; C014594:formestane