Effects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells.
1. Sodium butyrate increased alkaline phosphatase (ALP) activity of cloned osteoblastic cell line MC3T3-E1 by the stimulation of de novo enzyme synthesis. 2. Sodium butyrate did not affect mature osteoblastic cells but affected preosteoblastic cells. 3. Sodium butyrate decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC) formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone marrow cells.
Iwami
K
K
Department of Public Health, Nara Medical University, Japan.
Moriyama
T
T
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005227:Fatty Acids / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects* / Q000201:enzymology; D010010:Osteoclasts / Q000187:drug effects* / Q000201:enzymology; D000071681:Tartrate-Resistant Acid Phosphatase
D002087:Butyrates; D005227:Fatty Acids; D007527:Isoenzymes; D020148:Butyric Acid; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase