Angiotensin II and fluid ingestion in old rats.
Fluid ingestion was studied in Fischer 344/Brown Norway F1 rats aged 3, 12, 20, and 24 months of age. There was an age-related decrease in fluid ingestion when fluid intake was measured over 24 h. After water deprivation, 24- and 20-month-old rats drank less than 3- and 12-month-old rats. Twelve, 20-, and 24-month-old rats had less fluid intake associated with food deprivation than did 3-month-old rats. Three month old rats drank more fluid after angiotensin II than did 12-, 20-, and 24-month-old rats when expressed as fluid intake per kg body weight. These studies confirm that the rat is a reasonable model to study age-related hypodipsia.
Silver
A J
AJ
Education and Clinical Center, St. Louis Department of Veterans Affairs, MO 63104.
Morley
J E
JE
Ishimaru-Tseng
T V
TV
Morley
P M
PM
D000375:Aging / Q000523:psychology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D005508:Food Deprivation; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D014868:Water Deprivation
D000804:Angiotensin II