[Meningoradiculitis disclosing T-lymphocyte leukemia in HTLV-1 infection].
A case of HILV1-associated adult T cell leukaemia/lymphoma (ATLL) in à 21-year olf African woman is reported. The patient presented with lymphomatous meningoradiculopathy. The usual clinical features of ATLL were absent. Lumbar MRI showed a pial enhancement by DTPA-gadolinium of the conus medullaris which extended to the proximal cauda equina. Under systemic chemotherapy coupled with intrathecal chemotherapy the patient progressively improved, and at the second MRI examination complete disappearance of the lumbar enhancement was observed. MRI of the brain using axial and coronal T2-weighted sequences detected multifocal lesions of high-intensity signal in the subcortical white matter. ATLL is unusual in people of African origin. The ATLL-strongyloïdes infestation association has previously been reported, suggesting that parasitic infestation may be an important co-factor leading to the development of ATLL.
Visy
J M
JM
Service de Neurologie, Hôpital Lariboisière, Paris.
Vassel
P
P
Chaine
P
P
Woimant
F
F
Dumas
J L
JL
Lhote
F
F
Mainguene
C
C
Haguenau
M
M
D000328:Adult; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000134:cerebrospinal fluid / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid / Q000209:etiology*; D011843:Radiculopathy / Q000175:diagnosis / Q000209:etiology*; D013322:Strongyloidiasis / Q000150:complications
Méningo-radiculite révélatrice d'une leucémie à lymphocytes T au cours d'une infection à HTLV1.