title: Use of prostaglandin E1 to treat peri-anaesthetic pulmonary hypertension associated with mitral valve disease.
abstract: Severe pulmonary hypertension (PH) can be a critical problem during and after cardiac surgery, since it increases right ventricular afterload resulting in decreased cardiac output. A case of pulmonary hypertension associated with mitral valve disease and resistant to glyceryl trinitrate therapy during surgery is reported. The case was treated successfully with prostaglandin E1 (PGE1), indicating that PGE1 can be used peri-operatively in a patient with refractory PH resistant to glyceryl trinitrate treatment.
authors.affiliation: Department of Anaesthesiology, Kobe University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mikawa
authors.forename: N
authors.initials: N
authors.lastname: Maekawa
authors.forename: R
authors.initials: R
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Yaku
authors.forename: K
authors.initials: K
authors.lastname: Nishina
authors.forename: H
authors.initials: H
authors.lastname: Obara
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D000768:Anesthesia, General; D002315:Cardiopulmonary Bypass; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000601:surgery*; D008946:Mitral Valve Stenosis / Q000503:physiopathology / Q000601:surgery*; D005996:Nitroglycerin / Q000008:administration & dosage; D011300:Preoperative Care
chemical_list: D000527:Alprostadil; D005996:Nitroglycerin