[The use of clindamycin and netilmicin for preventing postoperative wound infection in patients with cancer of the upper respiratory and digestive tracts].
Clindamycin (2.7 g/day) and netilmicin (5.6 mg/kg) were used for 6-10 days in 27 patients with laryngeal and oral cancer versus beta-lactam antibiotics and aminoglycosides received by 56 matched patients to prevent infection of the operative wound. Suppuration was observed in 11.1 and 41.4% of the patients, respectively (p < 0.05), the temperature rose over 38 degrees C in 22.2% and 42.9% of the patients, respectively (p < 0.05). The regimens showed similar toxicity. The findings proved high efficacy of clindamycin combination with netilmicin in infection prophylaxis in patients operated on for upper respiratory and digestive tract cancer.
Dmitrieva
N V
NV
Petukhova
I N
IN
Borisova
O K
OK
Alferov
V S
VS
Uvarov
A A
AA
Akhundov
A A
AA
Kuznetsov
M K
MK
D002228:Carbenicillin / Q000008:administration & dosage / Q000009:adverse effects; D002439:Cefotaxime / Q000008:administration & dosage / Q000009:adverse effects; D002981:Clindamycin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D004067:Digestive System Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000008:administration & dosage* / Q000009:adverse effects; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D009428:Netilmicin / Q000008:administration & dosage / Q000009:adverse effects; D011182:Postoperative Care; D011300:Preoperative Care; D012142:Respiratory Tract Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*; D013997:Time Factors
D005839:Gentamicins; D002981:Clindamycin; D009428:Netilmicin; D002228:Carbenicillin; D002439:Cefotaxime
Primenenie klindamitsina i netilmitsina dlia profilaktiki posleoperatsionnoĭ ranevoĭ infektsii u bol'nykh rakom verkhnikh dykhatel'nykh i pishchevaritel'nykh puteĭ.