Evidence for the involvement of a 5-HT4 receptor in the secretory response of human small intestine to 5-HT.
5-Hydroxytryptamine increases transmucosal short-circuit current across human isolated small intestinal mucosa. The competitive 5-HT4 antagonist, DAU 6285 evoked a concentration-dependent, dextral and parallel shift of the concentration-response curve to 5-HT, with no alteration of the maximum response. Schild analysis of this antagonism produced a Schild regression with a slope of 1.00 and an apparent pA2 estimate of 6.17. It appears that a 5-HT4 receptor may mediate the short-circuit current response of human small intestinal mucosa to 5-HT.
Borman
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RA
Department of Pharmacology, Queen Mary and Westfield College, London.
Burleigh
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D001562:Benzimidazoles / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004594:Electrophysiology; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D011985:Receptors, Serotonin / Q000145:classification / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D001562:Benzimidazoles; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C074390:DAU 6285; D012701:Serotonin