title: Protothecosis in a patient with systemic lupus erythematosus.
abstract: A rare case of protothecosis in a 40-year-old Japanese woman with systemic lupus erythematosus, under long-term prednisolone treatment is presented. The patient developed extensive ulcerative skin lesions after injury. The characteristic histopathological findings and biochemical sugar assimilation tests indicated infection by Prototheca wicherhamii. The lesions improved following treatment with amphotericin B. The immunodeficient state of this patient seemed to contribute to the infection with Prototheca.
authors.affiliation: Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.forename: J
authors.initials: J
authors.lastname: Hirohara
authors.forename: Y
authors.initials: Y
authors.lastname: Fukui
authors.forename: S
authors.initials: S
authors.lastname: Fujinami
authors.forename: Y
authors.initials: Y
authors.lastname: Shiozaki
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Uoi
authors.forename: H
authors.initials: H
authors.lastname: Hosokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Asada
authors.forename: N
authors.initials: N
authors.lastname: Toyazaki
mesh_terms: D000038:Abscess / Q000150:complications / Q000382:microbiology; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D016867:Immunocompromised Host; D007239:Infections; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D011525:Prototheca; D012874:Skin Diseases, Infectious / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D012883:Skin Ulcer / Q000150:complications / Q000382:microbiology; D000092464:Elbow Injuries
chemical_list: D000666:Amphotericin B; D011239:Prednisolone