title: The effect of praziquantel treatment on the liver functions, worm burden, and granuloma size using two drug regimen in murine Schistosoma mansoni infection.
abstract: The effect of single dose of praziquantel (400 mg/kg) or two doses on two consecutive days was studied in mice infected with S. mansoni. With the single dose there was improvement in the serum protein pattern towards pre-infection values & a transient rise in serum transaminases which soon declined to normal. Improvement was more evident after using two doses of praziquantel (P < 0.001). Worms were eradicated by 70%. 77% and 80% after the single dose and by 88%, 92% and 95% after two doses. Granuloma size was reduced by 50%, 54% and 60% after single dose and by 58% and 73% respectively after 10, 20, and 30 days from treatment.
authors.affiliation: Department of Parasitology, Faculty of Medicine, University of Banha, Egypt.
authors.forename: A F
authors.initials: AF
authors.lastname: el-Fakahany
authors.forename: K F
authors.initials: KF
authors.lastname: Abdalla
authors.forename: H M
authors.initials: HM
authors.lastname: el-Hady
authors.forename: S M
authors.initials: SM
authors.lastname: Abd el-Aziz
authors.forename: L M
authors.initials: LM
authors.lastname: Afifi
mesh_terms: D000818:Animals; D005260:Female; D006099:Granuloma / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000254:growth & development; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
chemical_list: D011223:Praziquantel