title: Changing synaptic specificities in the nervous system of Caenorhabditis elegans: differentiation of the DD motoneurons.
abstract: During postembryonic development, the DD motoneurons in the nematode Caenorhabditis elegans completely reorganize their pattern of synapses. Ablation of a pair of embryonic precursors results in the absence of this entire class of motoneurons. In their absence animals exhibit two developmentally distinct locomotory defects. The transition period from one defect to the other is correlated with the synaptic reorganization of the DD mns. Mutations in a gene (unc-123) have been isolated that exhibit locomotory defects similar to those of the ablated adult animals. Genetic and cellular analyses of one of these alleles suggest that the unc-123 gene product may be involved in the reestablishment of functional synapses in these neurons.
authors.affiliation: Department of Biology, Georgia State University, Atlanta 30302-4010.
authors.forename: W W
authors.initials: WW
authors.lastname: Walthall
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: J A
authors.initials: JA
authors.lastname: Plunkett
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans; D002454:Cell Differentiation / Q000502:physiology; D015870:Gene Expression; D009043:Motor Activity / Q000235:genetics* / Q000502:physiology; D009046:Motor Neurons / Q000648:ultrastructure*; D009154:Mutation; D009420:Nervous System / Q000648:ultrastructure*; D013569:Synapses / Q000648:ultrastructure*