Enhanced detection of brain tumors by [18F]fluorodeoxyglucose PET with glucose loading.
OBJECTIVE
We applied glucose loading during PET studies with [18F]2-fluoro-2-deoxy-D-glucose (FDG) to enhance detection of brain tumors by diminution of FDG uptake in normal gray matter.


METHODS
This study involved three patients with glioblastomas. Two PET scans were performed in all cases within 1 week in control and with glucose loading state.


RESULTS
In all patients, tumor was depicted more clearly with glucose loading than in the control study. The FDG uptake ratio of tumor to normal cortical gray matter showed a mean increase of 27% with glucose loading.


CONCLUSIONS
This technique might be useful for detection of recurrent or residual tumors.
Ishizu
K
K
Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.
Sadato
N
N
Yonekura
Y
Y
Nishizawa
S
S
Magata
Y
Y
Tamaki
N
N
Tsuchida
T
T
Okazawa
H
H
Tanaka
F
F
Miyatake
S
S
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose