title: Resolution of membranoproliferative glomerulonephritis complicating angiofollicular lymph node hyperplasia (Castleman's disease).
abstract: A novel renal complication was reported in a patient with angiofollicular lymph node hyperplasia (Castleman's Disease), who developed acute renal failure due to membranoproliferative glomerulonephritis. Renal biopsy showed marked mesangial hyperplasia, basement membrane thickening with subendothelial electron-dense deposits, interstitial plasma cell infiltration, and glomerular deposition of IgM and complement components. A resolution of systemic manifestations and an improvement in renal function followed prednisolone and azathioprine therapy. Disease relapse, with increasing proteinuria and the development of factor 8 inhibitor, occurred 3 months later. Sustained remission was achieved with prednisolone and cyclophosphamide therapy, which were given for 42 and 12 months, respectively. Renal biopsy during remission showed significant resolution of the mesangial hyperplasia and disappearance of interstitial plasmacytic infiltration as well as subendothelial electron-dense deposits.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital.
authors.forename: T M
authors.initials: TM
authors.lastname: Chan
authors.forename: I K
authors.initials: IK
authors.lastname: Cheng
authors.forename: K L
authors.initials: KL
authors.lastname: Wong
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D003165:Complement System Proteins / Q000032:analysis; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007676:Kidney Failure, Chronic / Q000209:etiology; D007678:Kidney Glomerulus / Q000737:chemistry / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis
chemical_list: D007075:Immunoglobulin M; D003520:Cyclophosphamide; D003165:Complement System Proteins; D011239:Prednisolone; D001379:Azathioprine