Type IV renal tubular acidosis and spironolactone therapy in the elderly.
Spironolactone therapy is a well-known cause of hyperkalaemia, but in susceptible patient, it may also be associated with metabolic acidosis. We report a case of severe renal tubular acidosis (Type IV) with life-threatening hyperkalaemia caused by spironolactone, and discuss the mechanisms by which this may occur.
O'Connell
J E
JE
Geriatric Medicine Unit, University of Edinburgh, City Hospital, UK.
Colledge
N R
NR
D000141:Acidosis, Renal Tubular / Q000139:chemically induced*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D013148:Spironolactone / Q000009:adverse effects*
D013148:Spironolactone