title: Immunological effects of acute and chronic nicotine administration in rats.
abstract: We previously demonstrated that acute nicotine administration decreased the response of rat blood leukocytes (PBL) to concanavalin A (ConA). We now extend those findings to a comparison between the effects of acute and prolonged nicotine exposure (ten daily injections), on PBL and splenocytes (SL). A single injection suppressed the PBL response to ConA and phytohemagglutinin (PHA); tolerance developed by ten injections. In contrast, acute nicotine did not affect SL response to ConA and reduced the PHA response only at the highest concentration. Ten nicotine injections enhanced SL responsiveness to PHA. The only change in PBL subsets was an increase in CD8+ cells following ten injections.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, PA 15213.
authors.forename: C G
authors.initials: CG
authors.lastname: McAllister
authors.forename: A R
authors.initials: AR
authors.lastname: Caggiula
authors.forename: S
authors.initials: S
authors.lastname: Knopf
authors.forename: L H
authors.initials: LH
authors.lastname: Epstein
authors.forename: A L
authors.initials: AL
authors.lastname: Miller
authors.forename: S M
authors.initials: SM
authors.lastname: Antelman
authors.forename: K A
authors.initials: KA
authors.lastname: Perkins
mesh_terms: D000818:Animals; D005938:Glucocorticoids / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005938:Glucocorticoids; D009538:Nicotine