Anti-neutrophil cytoplasmic antibodies (ANCA) and infection.
As ANCA are occasionally noted in patients with infectious disorders independently of any vasculitis process, we examined serum from patients with acute infection (n = 22) and septic shock (n = 57). Only two patients with acute infection were ANCA positive as determined by indirect immunofluorescence and western blot analysis. The clinical recovery of both patients was associated with negative immunofluorescence and western blot tests.
Mege
J L
JL
Laboratory of Immunology, Hopital de Sainte-Marguerite, Marseille.
Escallier
J C
JC
Capo
C
C
Bongrand
P
P
Velut
J G
JG
Quiles
N
N
Soubeyrand
J
J
Durand
J M
JM
D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D005455:Fluorescent Antibody Technique; D006192:Haemophilus Infections / Q000276:immunology; D006193:Haemophilus influenzae; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007239:Infections / Q000276:immunology*; D008875:Middle Aged; D018805:Sepsis / Q000276:immunology; D012772:Shock, Septic / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D007074:Immunoglobulin G