title: [Clinical study on intraoperative hyperketonemia in non-diabetic surgical patients under general anesthesia].
abstract: We measured plasma 3-hydroxybutyrate (3-OHBA) concentrations in 925 non-diabetic surgical patients who underwent various surgical procedures under various types of general anesthesia. Lactated Ringer's solution only was used as an intraoperative fluid. Among them, 46 patients (4.9%) developed high 3-OHBA levels of over 500 microM.l-1 during surgery. The causes of observed hyperketonemia would be surgical stress and preoperative fasting irrespective of 8 types of general anesthesia. Blood glucose, lactic acid, base excess and pH were not influenced by hyperketonemia. Prolonged recovery from anesthesia was not observed in any patients with hyperketonemia. Without any specific treatments, plasma 3-OHBA levels were unchanged or rather decreased in 70% of the patients whose 3-OHBA levels were over 500 microM. The results suggest that hyperketonemia below 500 microM.l-1 is not always disadvantageous in nondiabetic patients under general anesthesia.
authors.affiliation: Department of Anesthesiology, University of Hirosaki School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Ohkawa
authors.forename: T
authors.initials: T
authors.lastname: Iwakawa
authors.forename: N
authors.initials: N
authors.lastname: Ohtomo
authors.forename: M
authors.initials: M
authors.lastname: Kitayama
authors.forename: A
authors.initials: A
authors.lastname: Miyahara
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: A
authors.initials: A
authors.lastname: Matsuki
mesh_terms: D020155:3-Hydroxybutyric Acid; D000328:Adult; D000768:Anesthesia, General; D003920:Diabetes Mellitus; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood*; D007431:Intraoperative Complications; D007662:Ketosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000150:complications
chemical_list: D006885:Hydroxybutyrates; D020155:3-Hydroxybutyric Acid