An association between the lysosomal enzyme NAG and urinary free cortisol and platelet imipramine binding.
Urinary levels of the lysosomal enzyme N-acetyl-beta-glucosaminidase (NAG) were significantly correlated to levels of 24-hour urinary free cortisol in a group of panic disordered patients. In a separate study of healthy controls NAG levels showed a trend toward association with platelet imipramine binding density. A hypothesis is proposed that NAG levels may be proportional to the density of postsynaptic serotonin receptors.
Garvey
M J
MJ
Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
Black
D W
DW
D000118:Acetylglucosaminidase / Q000652:urine*; D015415:Biomarkers; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000201:enzymology; D016584:Panic Disorder / Q000175:diagnosis / Q000201:enzymology*; D011955:Receptors, Drug / Q000378:metabolism*; D012016:Reference Values
D015415:Biomarkers; D002352:Carrier Proteins; D011955:Receptors, Drug; C027775:imipramine receptor; D000118:Acetylglucosaminidase; D006854:Hydrocortisone