title: Comparison of 2-chloroprocaine and prilocaine for intravenous regional anaesthesia of the arm: a clinical study.
abstract: In a double-blind, randomised study of patients scheduled for minor hand surgery 0.5% 2-chloroprocaine (n = 30) and 0.5% prilocaine (n = 30) in a volume of 40 ml were compared for intravenous regional anaesthesia. The onset of sensory and motor block and recovery of sensory block were determined, and the occurrence of side-effects was noted. Twenty-four patients in the 2-chloroprocaine group and 17 in the prilocaine group developed complete sensory block by 15 min after injection (p < 0.05). Complete recovery of sensation was faster after prilocaine (7.1 min) than 2-chloroprocaine (9.8 min) (p < 0.01). Venous irritation and/or urticaria after tourniquet release was observed on 10 occasions in those receiving 2-chloroprocaine and twice in those receiving prilocaine. An increase in heart rate of > 20% above control values occurred in three patients, all of whom had been given 2-chloroprocaine. Clinically, local anaesthetic properties of 0.5% 2-chloroprocaine and prilocaine were similar, but there were more side-effects with the former drug.
authors.affiliation: Department of Anesthesiology, Helsinki University Central Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Pitkänen
authors.forename: J
authors.initials: J
authors.lastname: Kyttä
authors.forename: P H
authors.initials: PH
authors.lastname: Rosenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000765:Anesthesia, Conduction; D000771:Anesthesia, Intravenous; D000779:Anesthetics, Local / Q000009:adverse effects; D001132:Arm; D004311:Double-Blind Method; D006225:Hand / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D013511:Minor Surgical Procedures; D011318:Prilocaine / Q000009:adverse effects / Q000494:pharmacology; D011343:Procaine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D014111:Tourniquets
chemical_list: D000779:Anesthetics, Local; D011318:Prilocaine; D011343:Procaine; C004616:chloroprocaine