title: [The hypoazotemic and diuretic action of lespeflan in acute kidney failure].
abstract: Hypoazotemic and diuretic effects of a new bioflavonoid drug lespephlan made in Russia have been tested in a dose 2 ml/kg to treat acute renal failure induced by mercury bichloride solution (a dose 2 mg/kg). The data were obtained on lespephlan ability to reduce blood levels of urea, creatinine and activate their renal elimination, to enhance diuresis, sodium clearance, glomerular filtration. Water and electrolyte release were also changeable by angiotensin aldosterone system. Mechanism of lespephlan hypoazotemic action is related to hepatic arginase inhibited activity as this enzyme plays a key role in detoxication of nitrous products urea and creatinine.
authors.forename: V G
authors.initials: VG
authors.lastname: Guliaev
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Ivanov
authors.forename: S F
authors.initials: SF
authors.lastname: Guliaeva
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000627:therapeutic use*; D006027:Glycosides / Q000627:therapeutic use*; D008627:Mercuric Chloride; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014511:Uremia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004232:Diuretics; D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts; C085745:lespeflan; D008627:Mercuric Chloride
vernacular_title: Gipoazotemicheskoe i dureticheskoe deĭstvie lespefalana pri ostroĭ pochechnoĭ nedostatochnosti.