title: Pediatric spinal bone marrow: assessment of normal age-related changes in the MRI appearance.
abstract: A retrospective study of 100 children (0-15 years) without known bone marrow abnormality, was performed to elucidate the spectrum of the MRI appearance of spinal bone marrow with age on T1-weighted images at 0.5 T. Fatty marrow distribution and vertebral signal intensity (SI) relative to disk SI were noted in each subject, and allowed the identification of distinctive patterns. The spinal marrow patterns and their relative frequency for different age groups were consistent with the known physiologic conversion from cellular to fatty marrow with age. Between the ages of 0 and 1 year, SI of corporeal ossification centers was similar or lower than SI of adjacent cartilage and disk in 87% of cases. Between the ages of 5 and 15 years, vertebral SI was higher than SI of adjacent disks in 90% of cases. A central or basivertebral zone of high SI consistent with focal fatty marrow was found in 16% and 31% of cases respectively. In conclusion, knowledge of these conversion patterns should serve as a practical aid in the interpretation of MRI examinations of the spine in children.
authors.affiliation: Hôpital des Enfants-Malades, Paris, France.
authors.forename: G H
authors.initials: GH
authors.lastname: Sebag
authors.forename: J
authors.initials: J
authors.lastname: Dubois
authors.forename: M
authors.initials: M
authors.lastname: Tabet
authors.forename: A
authors.initials: A
authors.lastname: Bonato
authors.forename: D
authors.initials: D
authors.lastname: Lallemand
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000033:anatomy & histology* / Q000254:growth & development; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007403:Intervertebral Disc / Q000033:anatomy & histology / Q000254:growth & development; D008279:Magnetic Resonance Imaging; D008297:Male; D012016:Reference Values; D012189:Retrospective Studies; D013131:Spine / Q000033:anatomy & histology* / Q000254:growth & development