title: Drosophila protein tyrosine phosphatases.
abstract: Seven protein tyrosine phosphatase (PTPase) genes have been identified in the fruit-fly Drosophila melanogaster. Four of these genes encode receptor-linked PTPases (R-PTPs) that are expressed on central nervous system axons in the embryo. Each axonal R-PTP has an extracellular domain that is homologous to vertebrate adhesion molecules and to identified mammalian R-PTPs. Two non-receptor PTPase genes have been isolated to date. One of these, corkscrew (csw), encodes an SH2 domain-containing PTPase that appears to be a homolog of mammalian PTP1D. Genetic evidence indicates that the csw PTPase is involved in the transduction of signals from receptor tyrosine kinases to their down-stream targets, which include Ras proteins.
authors.affiliation: Division of Biology 216-76, California Institute of Technology, Pasadena 91125.
authors.forename: K
authors.initials: K
authors.lastname: Zinn
mesh_terms: D000818:Animals; D001369:Axons / Q000201:enzymology; D002490:Central Nervous System / Q000201:enzymology; D004331:Drosophila melanogaster / Q000196:embryology / Q000201:enzymology*; D015870:Gene Expression; D017344:Genes, Insect; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D017027:Protein Tyrosine Phosphatases