title: DNA aneuploidy in ectopic pregnancy and spontaneous abortions.
abstract: The nuclear DNA content of 55 ectopic tubal pregnancies was studied by flow cytometry from paraffin embedded tissue blocks. An abnormal amount of DNA content was found in 24% of the cases. This was a significantly higher percentage than encountered in 92 spontaneous abortions studied by the same method in the same population (8%, P = 0.01). The result indicates that, in addition to the maternal factors, abnormal embryogenesis with grave chromosomal aberrations may play a major role in the etiology of ectopic pregnancy.
authors.affiliation: Department of Pathology, University Central Hospital of Turku, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Toikkanen
authors.forename: H
authors.initials: H
authors.lastname: Joensuu
authors.forename: R
authors.initials: R
authors.lastname: Erkkola
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D004247:DNA / Q000032:analysis*; D005260:Female; D006801:Humans; D011003:Ploidies; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000235:genetics*
chemical_list: D004247:DNA