title: [Mechanisms of electrogenic secretion of potassium in endolymph].
abstract: Endolymphatic potential is assumed to result from active K transport into the endolymphatic compartment and passive K diffusion in the opposite direction. However, in several in vivo experiments, changes in endolymphatic potential differed from that in endolymphatic K concentration. Moreover, in in vitro experiments, a negative endolymphatic potential was observed in presence of ouabain without K gradient between the two compartments. These observations suggest that the coupling between the K transport and the genesis of the endolymphatic potential is not tight. Several factors may influence separately the endolymphatic potential and the K transport such as the acid-base equilibrium, the integrity of the Reissner's membrane, the hormonal status and the Na transport.
authors.affiliation: INSERM U. 251, Faculté Xavier Bichat, Université Paris 7, France.
authors.forename: E
authors.initials: E
authors.lastname: Ferrary
authors.forename: C
authors.initials: C
authors.lastname: Bernard
authors.forename: N
authors.initials: N
authors.lastname: Julien
authors.forename: O
authors.initials: O
authors.lastname: Sterkers
authors.forename: C
authors.initials: C
authors.lastname: Amiel
mesh_terms: D004710:Endolymph / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000032:analysis / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
vernacular_title: Mécanismes de la sécrétion électrogène de potassium dans l'endolymphe.