title: Inositol treatment raises CSF inositol levels.
abstract: Inositol is a key precursor for synthesis of phosphatidylinositol in a major second messenger signalling system. It is biologically active in syndromes such as respiratory distress syndrome but has been thought to be excluded from CNS by the blood-brain barrier. Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy.
authors.affiliation: Abarbanel Mental Health Center, Bat Yam, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Levine
authors.forename: A
authors.initials: A
authors.lastname: Rapaport
authors.forename: L
authors.initials: L
authors.lastname: Lev
authors.forename: Y
authors.initials: Y
authors.lastname: Bersudsky
authors.forename: O
authors.initials: O
authors.lastname: Kofman
authors.forename: R H
authors.initials: RH
authors.lastname: Belmaker
authors.forename: J
authors.initials: J
authors.lastname: Shapiro
authors.forename: G
authors.initials: G
authors.lastname: Agam
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007294:Inositol / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000188:drug therapy*
chemical_list: D007294:Inositol