title: Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.
abstract: A 68-year-old woman with parkinsonism showed cortical myoclonus and seizures under antiparkinsonian medication. Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures. EEG was abnormal and somatosensory-evoked potentials (SEPs) showed giant SEPs, transcortical reflex (C reflex) and jerk locked potentials. Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA). We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.
authors.affiliation: Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: F
authors.initials: F
authors.lastname: Moriwaka
authors.forename: T
authors.initials: T
authors.lastname: Matsuura
authors.forename: T
authors.initials: T
authors.lastname: Hamada
authors.forename: K
authors.initials: K
authors.lastname: Tashiro
mesh_terms: D000368:Aged; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D014635:Valproic Acid / Q000008:administration & dosage
chemical_list: D007980:Levodopa; D014635:Valproic Acid