[Combined treatment of head and neck cancers by radiation therapy and chemotherapy with a small dose of CDDP].
Two-route infusion chemotherapy with a smaller dose of CDDP was applied for combined modality treatment with radiation therapy for head and neck cancer from 1985 to 1992. To determine the appropriate dose of CDDP in this treatment, we investigated parameters concerned with its toxicity by comparing two groups given 5 and 10 mg of CDDP as a daily dose. Complete response was attained in 18 of 24 cases in the 5 mg group and 8 of 11 cases in the 10 mg group. The toxicity due to CDDP in this protocol was found generally to be slight in both groups. Among the parameters of toxicity, creatinine clearance was most affected. A decrease in 24 hr. creatinine clearance was noted in 15 of 29 cases in the 5 mg group and 10 of 12 cases in the 10 mg group. We had to discontinue this treatment after the first course because of lowered creatinine clearance in a patient in the 5 mg group. Stomatitis due to radiation therapy appeared to become worse in combination with this chemotherapy. The 10 mg dose of CDDP can be applied as a safe combination treatment with radiation therapy for head and neck cancer. To improve the outcome of this treatment modality for carcinomas of the tongue and oral floor, the 10 mg dose of CDDP was thought to be more beneficial. However, in the case of cumulative doses of CDDP over 100 mg, precaution should be taken to avoid the risk from the toxicity of more CDDP administration.
Higashikawa
M
M
Department of Otolaryngology, Osaka Medical College.
Makimoto
K
K
Imanaka
M
M
Haginomori
S
S
Takahashi
H
H
D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage* / Q000633:toxicity; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D008875:Middle Aged
D002945:Cisplatin