Folliculitis in Down's syndrome.
Twenty-two male and 20 female adults with Down's syndrome were examined. Ten of the men and two of the women had a follicular rash consistent with Malassezia folliculitis. Oral itraconazole treatment produced a significant improvement in the rash, accompanied by a decrease in the skin Malassezia count. Clinical relapse occurred when therapy was discontinued, and was accompanied by return of the Malassezia yeasts.
Kavanagh
G M
GM
Department of Dermatology, Bristol Royal Infirmary, U.K.
Leeming
J P
JP
Marshman
G M
GM
Reynolds
N J
NJ
Burton
J L
JL
D000284:Administration, Oral; D000328:Adult; D004314:Down Syndrome / Q000150:complications* / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008290:Malassezia; D008297:Male; D012008:Recurrence; D012867:Skin / Q000473:pathology
D017964:Itraconazole