title: Aldicarb poisoning. A case report with prolonged cholinesterase inhibition and improvement after pralidoxime therapy.
abstract: Aldicarb is the most potent of the commercially available carbamate pesticides and is an unusual source of acute human poisonings. We present the case of a 43-year-old man exposed to aldicarb who developed severe cholinergic symptoms and progressive weakness requiring intubation for 5 days. Both his red blood cell cholinesterase and plasma pseudocholinesterase levels were depressed for a minimum of 44 hours. He demonstrated neuromuscular improvement concurrent with pralidoxime administration. The pertinent medical literature on aldicarb poisoning is reviewed.
authors.affiliation: Section of Emergency Medicine, University of Arizona Health Sciences Center, Tucson.
authors.forename: J L
authors.initials: JL
authors.lastname: Burgess
authors.forename: J N
authors.initials: JN
authors.lastname: Bernstein
authors.forename: K
authors.initials: K
authors.lastname: Hurlbut
mesh_terms: D000328:Adult; D000448:Aldicarb / Q000037:antagonists & inhibitors / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D002802:Cholinesterases / Q000097:blood*; D006801:Humans; D008297:Male; D011041:Poisoning / Q000188:drug therapy / Q000201:enzymology; D011220:Pralidoxime Compounds / Q000627:therapeutic use*
chemical_list: D002801:Cholinesterase Reactivators; D011220:Pralidoxime Compounds; D000448:Aldicarb; D002802:Cholinesterases; C028797:pralidoxime