Effect of small doses of ethylene glycol monomethyl ether on the acetylcholinesterase and delta-aminolevulinic acid dehydratase activity in erythrocytes, blood and bone marrow of rats.
The effect of small doses of ethylene glycol monomethyl ether (EGMME) on the activity of acetylcholinesterase (ACHE) in erythrocytes and whole blood as well as on the delta-aminolevulinic acid dehydratase (ALA-D) in blood and bone marrow was studied in Wistar rats. Significant reduction in the activity of both enzymes was noted three days after ip administration of 200 mg/kg b.w. EGMME whereas seven days later the activity of both enzymes returned to the control levels. Activity of ALA-D in blood appeared to be most sensitive to EGMME, and reacted even to the lowest dose, which did not significantly alter activity of ACHE or ALA-D in bone marrow. Haematological parameters in all treated groups remained unaltered.
Lazewska
M
M
Laboratory of Experimental Hematology and Toxicology, Jagiellonian University, Kraków, Poland.
Tabarowski
Z
Z
Dabrowski
Z
Z
D000110:Acetylcholinesterase / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D006403:Hematologic Tests; D008297:Male; D000623:Porphobilinogen Synthase / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000008:administration & dosage / Q000633:toxicity*
D005026:Ethylene Glycols; D012997:Solvents; D000110:Acetylcholinesterase; D000623:Porphobilinogen Synthase; C005219:methyl cellosolve