title: Estradiol-17 beta-secreting adrenocortical tumor in a ferret.
abstract: Severe generalized alopecia and marked vulvar enlargement were observed in a 5-year-old spayed ferret with high serum estradiol concentrations. A neoplastic left adrenal gland was removed. Staining of the neoplastic cells for estradiol was demonstrated by use of immunohistochemistry. Clinical findings in this ferret were typical of adrenal-associated endocrinopathy, a syndrome characterized by increased secretion of adrenocortical hormones by hyperplastic or neoplastic adrenal glands.
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: N S
authors.initials: NS
authors.lastname: Lipman
authors.forename: R P
authors.initials: RP
authors.lastname: Marini
authors.forename: J C
authors.initials: JC
authors.lastname: Murphy
authors.forename: Z
authors.initials: Z
authors.lastname: Zhibo
authors.forename: J G
authors.initials: JG
authors.lastname: Fox
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D018246:Adrenocortical Adenoma / Q000150:complications / Q000378:metabolism / Q000601:surgery / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000209:etiology / Q000662:veterinary; D000505:Alopecia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D005289:Ferrets; D010052:Ovariectomy / Q000662:veterinary; D012726:Sexual Behavior, Animal; D013577:Syndrome; D014844:Vulva / Q000473:pathology
chemical_list: D004958:Estradiol