title: A 12-month study of policosanol oral toxicity in Sprague Dawley rats.
abstract: Policosanol is a natural mixture of higher aliphatic primary alcohols. Oral toxicity of policosanol was evaluated in a 12-month study in which doses from 0.5 to 500 mg/kg were given orally to Sprague Dawley (SD) rats (20/sex/group) daily. There was no treatment-related toxicity. Thus, effects on body weight gain, food consumption, clinical observations, blood biochemistry, hematology, organ weight ratios and histopathological findings were similar in control and treated groups. This study supports the wide safety margin of policosanol when administered chronically.
authors.affiliation: Centro de Productos Naturales, Havana City, Cuba.
authors.forename: C L
authors.initials: CL
authors.lastname: Alemán
authors.forename: R
authors.initials: R
authors.lastname: Más
authors.forename: C
authors.initials: C
authors.lastname: Hernández
authors.forename: I
authors.initials: I
authors.lastname: Rodeiro
authors.forename: E
authors.initials: E
authors.lastname: Cerejido
authors.forename: M
authors.initials: M
authors.lastname: Noa
authors.forename: A
authors.initials: A
authors.lastname: Capote
authors.forename: R
authors.initials: R
authors.lastname: Menéndez
authors.forename: A
authors.initials: A
authors.lastname: Amor
authors.forename: V
authors.initials: V
authors.lastname: Fraga
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015415:Biomarkers; D005233:Fatty Alcohols; D010975:Platelet Aggregation Inhibitors; C080710:policosanol