Restoration of bactericidal activity of peritoneal fluid by cimetidine but not ranitidine or famotidine in burned mice.
OBJECTIVE
To find out the effect of 20%, third degree burns and H2 receptor antagonists on peritoneal bactericidal activity.


METHODS
Animal experiment.


METHODS
Research laboratory of university school of medicine.


METHODS
52 mice in five groups.


METHODS
Sham burn (n = 5, group I), burned, and received subcutaneous injections of saline (0.3 ml/kg day, n = 14, group II); ranitidine (10 ml/kg/day, n = 15, group III); cimetidine (10 mg/kg/day, n = 8, group IV); or famotidine (0.7 mg/kg/day, n = 10, group V); for 14 days.


METHODS
Peritoneal bactericidal activity in all groups measured 15 days after the burn.


RESULTS
There was a significant difference in peritoneal bactericidal activity between the control and burned mice, but no significant difference between the control group and the burned mice that were given cimetidine and famotidine.


CONCLUSIONS
Peritoneal bactericidal activity is suppressed in mice after 20% third degree burns and this effect may be partly reversed by cimetidine and famotidine.
Altaca
G
G
Department of General Surgery, Bayindir Medical Center, Hacettepe University, Ankara, Turkey.
Sayek
I
I
Onat
D
D
Gür
D
D
Akalin
E
E
D000818:Animals; D001202:Ascitic Fluid / Q000382:microbiology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002056:Burns / Q000188:drug therapy* / Q000276:immunology; D002927:Cimetidine / Q000627:therapeutic use*; D015738:Famotidine / Q000627:therapeutic use*; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects; D051379:Mice; D010533:Peritoneal Lavage; D011899:Ranitidine / Q000627:therapeutic use*
D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine