Bovine natural killer activity against virally infected cells inhibited by monoclonal antibodies.
Forty-four monoclonal antibodies (mAbs) were evaluated for their ability to alter natural killer (NK) cell lysis of virally infected target cells. Six of the mAbs inhibited the lysis of the target cells, while one of the mAbs enhanced lysis. Four of the inhibitory mAbs, CACT26A, CACT16A, CACTB45A and MUC76A, had very marked activity. These mAbs with inhibitory or enhancing activity recognized (1) WC2 molecules (CACTB44A, CACT16A, CACT26A) present on putative NK cells, (2) molecules on granulocytes, monocytes, a subpopulation of lymphocytes (CACTB45A and TH2A), (3) CD11a (MUC76A), and a protein of CD3 (MM1A).
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Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison 53706.
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology; D002417:Cattle / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic / Q000662:veterinary; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D004285:Dogs; D007242:Herpesvirus 1, Bovine / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D012516:Osteosarcoma / Q000382:microbiology; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D015703:Antigens, CD