[The use of immunostimulants for enhancing the immunogenicity of a herpes vaccine].
National immunostimulators and interferon inducers (poludan, ridostin, larifan, myelopide, vegetan) in combination with a commercial herpes vaccine (HV) were used for experimental immunization of mice. A 3-fold or greater rise of specific antibody titres was observed after a single immunization of intact BALB/c mice. In experiments in chronically infected animals a single inoculation of HV resulted in a 3-fold rise of specific antibody titres at 6 days postimmunization but not in later periods (20, 30 days). Administration of larifan, an interferon inducer, but not the immunostimulator myelopide, induced a synergic effect in these experiments. Activation of alpha-interferon production was observed early after combined use of HV and immunostimulators. It is concluded that combined experimental use of HV and immunostimulators activated both specific antibody production and interferon production.
Barinskiĭ
I F
IF
Semenova
T B
TB
Posevaia
T A
TA
Alimbarova
L M
LM
Kolieva
M Kh
MKh
Shabalina
N V
NV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control; D018259:Herpesvirus 1, Human / Q000276:immunology*; D016898:Interferon-alpha / Q000097:blood / Q000187:drug effects; D008587:Meningitis, Viral / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014765:Viral Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D016898:Interferon-alpha; D014765:Viral Vaccines
Ispol'zovanie immunostimuliatorov dlia povysheniia immunogennosti gerpeticheskoĭ vaktsiny.