title: Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.
abstract: The effect of photodynamic therapy (PDT) on interstitial fluid pressure (IFP), tumour volume and water content was measured in melanomas grown in hamsters. Unlike control tumours, treated tumours exhibited a 40-60% increase in volume at 1, 3 and 6 h post PDT. IFP also increased at 1 and 3 h after PDT, but decreased to 50% of control value after 24 h, presumably as a result of PDT-induced microcirculatory impairment.
authors.affiliation: Institute for Surgical Research, University of Munich, Klinikum Grosshadern, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Leunig
authors.forename: A E
authors.initials: AE
authors.lastname: Goetz
authors.forename: F
authors.initials: F
authors.lastname: Gamarra
authors.forename: G
authors.initials: G
authors.lastname: Zetterer
authors.forename: K
authors.initials: K
authors.lastname: Messmer
authors.forename: R K
authors.initials: RK
authors.lastname: Jain
mesh_terms: D000818:Animals; D006224:Cricetinae; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D005110:Extracellular Space / Q000502:physiology; D006400:Hematocrit; D008027:Light; D008297:Male; D018328:Melanoma, Amelanotic / Q000098:blood supply / Q000188:drug therapy* / Q000503:physiopathology*; D008647:Mesocricetus; D010778:Photochemotherapy; D011312:Pressure; D012878:Skin Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000503:physiopathology*; D013997:Time Factors; D014867:Water / Q000032:analysis / Q000378:metabolism / Q000502:physiology*
chemical_list: D014867:Water; D017323:Dihematoporphyrin Ether