title: [Ceftriaxone-induced cholelithiasis--a harmless side-effect?].
abstract: 43 children suffering from borreliosis, meningitis and septicemia were treated with ceftriaxone. A six year old boy with acute jaundice due to ceftriaxone induced cholelithiasis encouraged us to reevaluate the frequency of ceftriaxone induced cholelithiasis and its' sequelae in children in a prospective study. Out of 43 children (age 6.3 years, 4 months to 16 years, male: female 25:18), 20 children (46.5%) showed sonographical evidence for ceftriaxone induced cholelithiasis after a treatment of at least 10 days. Two of them even had signs of intrahepatic cholestasis, 3 kids suffered from severe abdominal pain, non of them showed serologic abnormalities. Another 5 children (11.6%) had sludge in the gallbladder without evidence for cholelithiasis. In all patients the "pseudocholelithiasis" spontaneously resolved within at most 2 months. We suggest a sonographical examination of the gallbladder at the end of the ceftriaxone treatment in order to detect cholelithiasis, which might call for further monitoring and maybe dietary treatment.
authors.affiliation: Univ. Kinderklinik Graz.
authors.forename: M
authors.initials: M
authors.lastname: Riccabona
authors.forename: R
authors.initials: R
authors.lastname: Kerbl
authors.forename: W
authors.initials: W
authors.lastname: Schwinger
authors.forename: D
authors.initials: D
authors.lastname: Spork
authors.forename: M
authors.initials: M
authors.lastname: Millner
authors.forename: H M
authors.initials: HM
authors.lastname: Grubbauer
mesh_terms: D000293:Adolescent; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002769:Cholelithiasis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008193:Lyme Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D016920:Meningitis, Bacterial / Q000000981:diagnostic imaging / Q000188:drug therapy*; D018805:Sepsis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014463:Ultrasonography
chemical_list: D002443:Ceftriaxone
vernacular_title: Ceftriaxon-induzierte Cholelithiasis--eine harmlose Nebenwirkung?