title: Effect of cardiopulmonary bypass on gastrointestinal perfusion and function.
abstract: Gastric mucosal tonometry was used to determine the adequacy of gastrointestinal perfusion in 10 patients undergoing elective myocardial revascularization. Patients were prospectively randomized to receive either pulsatile or nonpulsatile flow during cardiopulmonary bypass. All patients showed a reduction in gastric mucosal perfusion during bypass, manifested by a reduction in the gastric mucosal pH, which occurred independently of variations in the arterial pH. In the group of patients receiving nonpulsatile flow, this reduction was significantly greater (p < 0.05). Cardiopulmonary bypass using nonpulsatile flow is associated with the development of a gastric mucosal acidosis, which may have implications for the development of postoperative complications.
authors.affiliation: Department of Cardiothoracic Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
authors.forename: J A
authors.initials: JA
authors.lastname: Gaer
authors.forename: A D
authors.initials: AD
authors.lastname: Shaw
authors.forename: R
authors.initials: R
authors.lastname: Wild
authors.forename: R I
authors.initials: RI
authors.lastname: Swift
authors.forename: C M
authors.initials: CM
authors.lastname: Munsch
authors.forename: P L
authors.initials: PL
authors.lastname: Smith
authors.forename: K M
authors.initials: KM
authors.lastname: Taylor
mesh_terms: D000138:Acidosis / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000379:methods*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011673:Pulsatile Flow; D012039:Regional Blood Flow