title: Ventilation perfusion radionuclide imaging in cryptogenic fibrosing alveolitis.
abstract: There is increasing interest in ventilation perfusion (V/Q) imaging in cryptogenic fibrosing alveolitis because of the data these scans provide on the dynamic V/Q relationships in such patients undergoing single lung transplantation. However, the full spectrum of V/Q abnormalities in this disease is poorly defined. We therefore analysed the V/Q scans of 45 consecutive patients with advanced cryptogenic fibrosing alveolitis being considered for single lung transplantation. Scans were classified according to the presence, severity and degree of matching of defects in ventilation and perfusion images and the results were compared with the data obtained from lung function tests. Ventilation images showed defects in 13 (29%) and 'washout delay' in 15 (33%) patients; 10 (22%) patients had asymmetric distribution of ventilation with one lung receiving > 60% of total ventilation. Perfusion images showed normal perfusion in 8 (18%), mild defects in 18 (40%) and major defects in 19 (42%) patients. The distribution of perfusion between lungs was significantly asymmetric in 20 (45%) patients. V/Q images were matched in 15 (33%), mildly mismatched in 15 (33%) and severely mismatched in 15 (33%) patients, but the degree of V/Q mismatch did not show a relationship to KCO, PaO2 or A-aO2 gradient. The appearances were atypical of pulmonary embolism in eight patients. V/Q images in cryptogenic fibrosing alveolitis show a diverse range of appearances and may mimic pulmonary embolism. V/Q imaging complements the data obtained from lung function tests and is particularly useful in defining the differential function of each lung which is particularly important in the assessment of patients for single lung transplantation.
authors.affiliation: Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bourke
authors.forename: T
authors.initials: T
authors.lastname: Hawkins
authors.forename: P M
authors.initials: PM
authors.lastname: Keavey
authors.forename: A D
authors.initials: AD
authors.lastname: Gascoigne
authors.forename: P A
authors.initials: PA
authors.lastname: Corris
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013902:Radiography, Thoracic; D011877:Radionuclide Imaging; D014692:Ventilation-Perfusion Ratio / Q000502:physiology*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes