title: Improved survival of burned patients with inhalation injury.
abstract: OBJECTIVE
  To study a cohort of patients treated at the same institution and to compare that patient population with that of a previous report documenting the comorbidity of inhalation injury and pneumonia. Specifically, we wanted to determine whether there had been an improvement in survival of patients suffering inhalation injury.
  
  
  METHODS
  A retrospective review.
  
  
  METHODS
  The US Army Institute of Surgical Research, Ft Sam Houston, Tex, a 40-bed burn intensive care referral unit.
  
  
  METHODS
  One thousand two hundred fifty-six thermally injured patients treated between January 1985 and December 1990.
  
  
  METHODS
  A comparison of pneumonia frequency and ultimate survival of the current cohort of patients as compared with a previously generated stepwise logistic analysis predicting mortality on the basis of 1980 to 1984 patient data.
  
  
  RESULTS
  Of 1256 burned patients admitted between 1985 and 1990, there were 330 identified as having inhalation injury. These patients were older (35.0 vs 26.6 years) and had more extensive burns (41.1% vs 18.3%) and a higher mortality (29.4% vs 5.0%) than did the patients without inhalation injury. When compared with a mortality predictor generated from 1980 through 1984 patient data, patients in the most recent period had a lower mortality than predicted (29.4% vs 41.4%). Patients with less severe injury (positive xenon scan, negative results of bronchoscopy; n = 85), although having a similar incidence of pneumonia (13.1% vs 19.5%) as the same group from 1980 through 1984, accounted for the most improvement in survival. The 3.6% mortality was significantly less than the predicted rate of 15.7%. Patients with positive results of bronchoscopy (n = 245) also showed some improvement in outcome from that predicted (38.3% vs 50.2%) despite no change in the rate of pneumonia (46.9% vs 48.5%). Further improvement in survival was realized in those patients supported with high-frequency ventilation. Although their age (33.9 vs 36.3 years), burn size (46.0% vs 45.5%), and duration of intubation (16.8 vs 15.1 days) were similar to those of conventionally treated patients, mortality was significantly less than predicted (16.4% vs 40.9%) and less than that in patients treated with conventional ventilation (16.4% vs 42.7%).
  
  
  CONCLUSIONS
  The improvement in survival of patients with inhalation injury represents the aggregate effects of the general improvement and outcome of all burned patients, the prevention of pneumonia by high-frequency ventilation, and the reduced mortality from the pneumonias that did occur.
authors.affiliation: US Army Institute of Surgical Research, Ft Sam Houston, Tex.
authors.forename: L W
authors.initials: LW
authors.lastname: Rue
authors.forename: W G
authors.initials: WG
authors.lastname: Cioffi
authors.forename: A D
authors.initials: AD
authors.lastname: Mason
authors.forename: W F
authors.initials: WF
authors.lastname: McManus
authors.forename: B A
authors.initials: BA
authors.lastname: Pruitt
mesh_terms: D000328:Adult; D002059:Burns, Inhalation / Q000150:complications / Q000401:mortality*; D015331:Cohort Studies; D006612:High-Frequency Ventilation; D006772:Hospitals, Military; D006801:Humans; D011014:Pneumonia / Q000453:epidemiology / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D012189:Retrospective Studies; D015996:Survival Rate; D013781:Texas