[Complications of fibrinolytic therapy in thromboses of the major arteries of the lower extremities].
Fibrinolytic therapy with streptokinase preparations was administered to 79 patients. Hemorrhagic, embolic, thrombotic, and allergic complications were observed over the course of therapy. Massive bleedings occurred in 3 (4%) patients, two of them died. Negligible hematomas at the site of vessel puncture were seen in 11 (14.4%) cases. Distal arteries embolization developed in 6 (7.6%) patients. Nine patients (11.4%) developed early re-thromboses soon after therapy was over. Allergic reactions presenting as hyperthermia and short-term chill were observed in one third of the patients. Measures to prevent possible complications of fibrinolytic therapy are strict adherence to thrombolysis methods and a dynamic laboratory monitoring over the course of therapy.
Rodionov
S V
SV
Farber
A Ia
AIa
Safonov
M V
MV
Butenko
A V
AV
D000328:Adult; D000368:Aged; D001158:Arteries; D004342:Drug Hypersensitivity / Q000209:etiology; D004617:Embolism / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D007511:Ischemia / Q000139:chemically induced; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D013300:Streptokinase / Q000009:adverse effects*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D013927:Thrombosis / Q000150:complications* / Q000188:drug therapy
D013300:Streptokinase
Oslozhneniia fibrinoliticheskoĭ terapii trombozov magistral'nykh arteriĭ nizhnikh konechnosteĭ.