title: [Pathology of primary pulmonary hypertension].
abstract: Morphological investigation of 12 cases of primary pulmonary hypertension (PPH) (4 males and 8 females, from 20 to 48 years old, duration of the disease from 1 to 10 years) is performed. Heart weight increase (from 390 to 640 g) and thickening of the right ventricle wall were observed. 3 groups were distinguished on the basis of histology: 1) plexigenic pulmonary arteriopathy (PPA)-2 cases, 2) recurrent pulmonary thromboembolism (RPT)-5 cases, 3) vein-occlusive disease (VOD-5 cases. The third group was divided into two subgroups: vascular-occlusive disease (VOD) with thrombotic lesions of arteries and veins and vein-occlusive disease proper (VOD-p) with thrombosis of pulmonary veins only. Morphometrically, thickening of arterial intima and media was found in PPA and RPT and in some cases of VOD-p. The thickening of the above layers in veins found in some cases of PPA and RPT was obviously secondary and indicated the development of mixed pre- and postcapillary pulmonary hypertension.
authors.forename: I E
authors.initials: IE
authors.lastname: Chazova
authors.forename: V S
authors.initials: VS
authors.lastname: Zhdanov
authors.forename: S P
authors.initials: SP
authors.lastname: Beselova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Mareev
mesh_terms: D000328:Adult; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology*; D008168:Lung / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D011655:Pulmonary Embolism / Q000473:pathology; D012008:Recurrence; D014652:Vascular Diseases / Q000473:pathology
vernacular_title: Patologiia pervichnoĭ legochnoĭ gipertenzii.