[Severity of myasthenia gravis is related to the degree of neuromuscular blocking effect by isoflurane].
We studied neuromuscular blocking effects of isoflurane using a neuromuscular transmission monitor in three myasthenia gravis patients. Severity of myasthenia gravis was different among three patients. T1 decreased by 12% in a mild case (I type), by 18% in a moderate case (IIa type) and by 42% in severe case (III type) during isoflurane anesthesia. Also, TOF ratio decreased by 12% in a mild case, by 22% in a moderate case, and 48% in a severe case during isoflurane anesthesia. We conclude that in patients with more severe myasthenia gravis, neuromuscular blocking effect of isoflurane is more potentiated.
Kadosaki
M
M
Department of Anesthesiology, Akita University School of Medicine.
Enzan
K
K
Horiguchi
T
T
Komatsu
H
H
Suzuki
M
M
D005260:Female; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*
D009466:Neuromuscular Blocking Agents; D007530:Isoflurane