title: The effect of long-term ingestion of glucocorticoids on liver and serum plasma in rats.
abstract: The effect of chronic hydrocortisone administration (0.5 mg/kg) on the liver and plasma lipid content was assessed in Wistar rats. It was found after that the liver cholesterol content was significantly increased 6 months of hydrocortisone treatment. At the same time, the distribution of liver phospholipid fractions was altered. The fatty acid composition of liver lipids showed a significant increase of 22:6 n-3. Decreased levels of cholesterol and LDL-cholesterol were found in the plasma of the hydrocortisone-treated rats.
authors.affiliation: Institute for Medical Research, Belgrade, Serbia.
authors.forename: G
authors.initials: G
authors.lastname: Petrovic
authors.forename: V
authors.initials: V
authors.lastname: Ristic
authors.forename: S
authors.initials: S
authors.lastname: Vrbaski
authors.forename: M
authors.initials: M
authors.lastname: Ristic
authors.forename: S
authors.initials: S
authors.lastname: Suzic
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D008055:Lipids; D008077:Lipoproteins, LDL; D010743:Phospholipids; D002784:Cholesterol; D006854:Hydrocortisone