Giant cell tumor arising in Paget's disease of bone. Recurrences after 36 years.
A 96-year-old woman had both Paget's disease and a giant cell tumor of the same bone, the left scapula. Despite five surgical procedures, a full course of radiation therapy, and treatment with salmon calcitonin, human calcitonin, and finally disodium etidronate, the tumor has recurred over a 36-year period. The characteristic viral-like nuclear and cytoplasmic inclusions found in the osteoclasts of Paget's disease were found in the tumor giant cells, in specimens excised over an eight-year period, and in specimens obtained during orthopedic procedures on her other pagetic bone lesions over 12 years.
Singer
F R
FR
Cedars-Sinai Medical Center, UCLA School of Medicine.
Mills
B G
BG
D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000150:complications* / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D005870:Giant Cell Tumors / Q000150:complications* / Q000473:pathology; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010001:Osteitis Deformans / Q000150:complications* / Q000473:pathology; D012540:Scapula / Q000473:pathology*; D013997:Time Factors