title: Nerve growth factor affects defense-related behaviors, but not lordosis, in ovariectomized, estrogen-treated rats.
abstract: Effects of NGF and anti-NGF on estrogen-sensitive behaviors were examined in ovariectomized, estrogen-treated rats. Intracerebroventricular (i.c.v.) administration of NGF resulted in a significant decrease in body weight. Daily treatment with low levels of estradiol resulted in a steady increase in lordosis behavior as reflected by average lordosis quotient and lordosis score. No effects of NGF or anti-NGF on lordosis behavior were detected. Estrogen treatment also resulted in a significant increase in the number of vocalizations elicited from female controls by male contact during sex behavior. NGF-treatment enhanced this effect, resulting in significantly more vocalizations elicited earlier in the course of estrogen treatment than were elicited from non-NGF-treated controls. These effects were blocked by progesterone. An increase in the number of rejections elicited by male contact during sex behavior was also observed in NGF-treated animals relative to controls. In addition, i.c.v. infusions of anti-NGF prevented the estrogen-mediated increase in elicited vocalizations, suggesting that NGF may have a physiological role in regulating this behavior. These data implicate NGF in the regulation of specific defense-related behaviors in estrogen-treated rats. Effects of NGF and anti-NGF on immunocytochemical staining for p75NGFR-, and ChAT-like immunoreactivity were also analyzed and are discussed.
authors.affiliation: Rockefeller University, New York, NY 10021.
authors.forename: R B
authors.initials: RB
authors.lastname: Gibbs
authors.forename: M M
authors.initials: MM
authors.lastname: McCarthy
authors.forename: D W
authors.initials: DW
authors.lastname: Pfaff
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects; D002795:Choline O-Acetyltransferase / Q000276:immunology / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D009414:Nerve Growth Factors / Q000037:antagonists & inhibitors / Q000276:immunology / Q000494:pharmacology*; D010052:Ovariectomy; D011187:Posture; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014828:Vocalization, Animal / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
chemical_list: D009414:Nerve Growth Factors; D011374:Progesterone; D004958:Estradiol; D002795:Choline O-Acetyltransferase