Transcriptional antitermination.
Antiterminator proteins control gene expression by recognizing control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream. The N protein of bacteriophage lambda recognizes a sequence in the nascent RNA, and modifies RNA polymerase by catalysing the formation of a stable ribonucleoprotein complex on its surface, whereas the lambda Q protein recognizes a sequence in the DNA. These mechanisms of antitermination in lambda provide models for analysing antitermination in viruses such as HIV-1 and in eukaryotic genes.
Greenblatt
J
J
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada.
Nodwell
J R
JR
Mason
S W
SW
D010582:Bacteriophage lambda / Q000235:genetics; D001483:Base Sequence; D015696:Gene Products, tat / Q000502:physiology; D015497:HIV-1 / Q000235:genetics; D008969:Molecular Sequence Data; D014158:Transcription, Genetic / Q000502:physiology*; D014764:Viral Proteins / Q000502:physiology; D054334:Viral Regulatory and Accessory Proteins / Q000502:physiology*; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; C059417:N protein, Bacteriophage lambda; C066119:Q protein, Bacteriophage lambda; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; D054322:tat Gene Products, Human Immunodeficiency Virus