Captopril renoscintigraphy with Tc-99m DTPA in patients with suspected renovascular hypertension. Prospective and retrospective evaluation.
Sensitivity and specificity of captopril renoscintigraphy (CRS) with Tc-99m DTPA has been analyzed in 41 cases, 16 with renovascular hypertension (RVH) and 25 with non-RVH. The sensitivity and specificity of the baseline study were 63% (10/16) and 63% (12/19), respectively, based on the split renal function study in which the lower limit of normal was assumed to be 42% of the total renal uptake. Captopril renoscintigraphy yielded 67% (12/18) sensitivity and 76% (19/25) specificity. The low specificity of CRS was due to the application of a prospective criterion of the captopril-induced reduction rate (CRR) of less than -20%, which was calculated from the renal uptake before and after captopril. When criteria of CRR less than -25% were used, the specificity of CRS was improved to 96%, but the sensitivity declined to 61%. Changes in the configuration of the renogram induced by captopril also had high specificity but low sensitivity. Renovascular hypertension was most likely when criteria for both CRR and the renogram were fulfilled. These criteria often were diagnostic in patients with bilateral renal artery stenosis that showed variable scintigraphic responses to captopril challenge. Captopril renoscintigraphy is a very specific means to evaluate RVH, but may have limitations in certain clinical situations such as poorly preserved function of the affected kidney, prior long-term administration of captopril, prior surgical manipulation of stenotic renal artery, and chronic renal parenchymal damage.
Itoh
K
K
Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Tsukamoto
E
E
Nagao
K
K
Nakada
K
K
Kanegae
K
K
Furudate
M
M
D000328:Adult; D002216:Captopril; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D011866:Radioisotope Renography / Q000379:methods*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016284:Technetium Tc 99m Pentetate
D002216:Captopril; D016284:Technetium Tc 99m Pentetate