[The effect of preparations with nootropic action when used long-term on the brain bioelectrical activity in rats].
The impact of prolonged injection of piracetam (2 months), meclophenoxate (5 months), and mexidole (5 months) on the bioelectrical activity of the sensomotor cortex and dorsal hippocamp was studied in rats who behaved freely. The injects increased and stabilized the predominant peak of EEC spectra power by the Fourier method. Discontinuation (24 hours) of piracetam failed to impair EEG spectra and bioelectrical activity. Increasing the basic effects of nootropic drugs given chronically versus acutely suggests that chronic injection enhanced their action. The drugs under study elevated the level of wakefulness and excitability of the animals, which is likely to underlie the neurophysiological mechanisms responsible for behaviour optimization under the influence of these agents.
Krapivin
S V
SV
Sopyev
Zh A
ZhA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D004594:Electrophysiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D008297:Male; D002504:Meclofenoxate / Q000494:pharmacology; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology; D010847:Picolines / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate; D002504:Meclofenoxate; D010889:Piracetam
Vliianie preparatov s nootropnoĭ aktivnost'iu pri ikh dlitel'nom primenenii na bioélektricheskuiu aktivnost' mozga krys.