title: New electron microscopic findings in a case of multicentric reticulohistiocytosis. Long spacing collagen inclusions.
abstract: The case of a 68-year-old woman with polyarthropathy and skin nodules is presented. Histologic findings of histiocytes with ground-glass cytoplasm favored the diagnosis of multicentric reticulohistiocytosis. In this article we report new electron microscopic findings of intra- and extracytoplasmic long spacing collagen (type VI). Type VI collagen inclusions are usually found in lymphohistiocytic neoplasms. We believe our findings support the concept of a proliferative rather than inflammatory etiology for multicentric reticulohistiocytosis. It may also give support for the argument of production of collagen by the histiocytic cells of multicentric reticulohistiocytosis.
authors.affiliation: Clinique dermatologique, Centre Hospitalier et Universitaire de Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Fortier-Beaulieu
authors.forename: E
authors.initials: E
authors.lastname: Thomine
authors.forename: M C
authors.initials: MC
authors.lastname: Boullie
authors.forename: X
authors.initials: X
authors.lastname: Le Loët
authors.forename: P
authors.initials: P
authors.lastname: Lauret
authors.forename: J
authors.initials: J
authors.lastname: Hemet
mesh_terms: D000368:Aged; D003094:Collagen / Q000648:ultrastructure*; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006801:Humans; D012867:Skin / Q000648:ultrastructure*; D012871:Skin Diseases / Q000473:pathology*
chemical_list: D003094:Collagen