title: Cyclosporine-induced hemolytic uremic syndrome in a heart transplant recipient.
abstract: We report a case of hemolytic uremic syndrome associated with the use of cyclosporine in a heart transplant recipient. The patient manifested many classic signs and symptoms of hemolytic uremic syndrome, and a diagnosis was confirmed by kidney biopsy. Treatment with plasma exchange was effective in halting the hemolysis, but renal function failed to improve. Rechallenge with cyclosporine caused recurrence of microangiopathic hemolysis. Because of concerns regarding allograft rejection, an experimental immunosuppressive agent, RS-61443, was used that was effective in controlling rejection and was not associated with recurrence of hemolytic uremic syndrome.
authors.affiliation: Division of Cardiology, University of California, San Francisco 94143.
authors.forename: F C
authors.initials: FC
authors.lastname: Galli
authors.forename: L E
authors.initials: LE
authors.lastname: Damon
authors.forename: S J
authors.initials: SJ
authors.lastname: Tomlanovich
authors.forename: F
authors.initials: F
authors.lastname: Keith
authors.forename: K
authors.initials: K
authors.lastname: Chatterjee
authors.forename: T
authors.initials: T
authors.lastname: DeMarco
mesh_terms: D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D016027:Heart Transplantation; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D016572:Cyclosporine