title: Immunohistochemical analysis of 61 pituitary adenomas with a monoclonal antibody to the neuron-specific beta-tubulin isotype.
abstract: Pituitary adenomas surgically resected from 61 consecutive patients and 9 normal pituitary glands were studied by immunohistochemistry to determine the localization of the class III beta-tubulin isotype(neuron-specific) which is recognized by the monoclonal antibody TUJ1. In normal pituitary glands only a few cells were weakly immunopositive for TUJ1, whereas, in 43(73%) of 61 adenomas, more than 5% of tumor cells were immunopositive. The result may indicate that this neuron-specific beta-tubulin isotype may be either expressed de novo or enhanced under the transformation of pituitary acinar cells to tumors.
authors.affiliation: Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Furuhata
authors.forename: T
authors.initials: T
authors.lastname: Kameya
authors.forename: S
authors.initials: S
authors.lastname: Toya
authors.forename: A
authors.initials: A
authors.lastname: Frankfurter
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D000911:Antibodies, Monoclonal; D006801:Humans; D007536:Isomerism; D009474:Neurons / Q000737:chemistry*; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000473:pathology*; D014404:Tubulin / Q000737:chemistry* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D014404:Tubulin