title: [The peptide modulation of immune reactions].
abstract: A dose-dependent immunomodulating effect of synthetic low-molecular weight peptides was found in CBA mice. Talcin and its analogue, rigin, tripeptide SKE, substance P and its analogue, and vasopressin were shown to produce an immunostimulating effect, whereas vasopressin tetrapeptide, arginyl-asparagine, and tripeptide SKD showed an immunosuppressive effect. The immunomodulatory effect of the peptides tested was associated with the presence of amino acids such as arginine, lysine, tyrosine, glutamic acid in their chemical structure. These amino acids are essential in the mechanisms of immune responses.
authors.forename: M A
authors.initials: MA
authors.lastname: Cheĭdo
authors.forename: G V
authors.initials: GV
authors.lastname: Idova
authors.forename: O S
authors.initials: OS
authors.lastname: Pansuevich
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides
vernacular_title: Peptidnaia moduliatsiia immunnykh reaktsiĭ.