title: Antileishmanial activity of the ether phospholipid ilmofosine.
abstract: The ether phospholipid ilmofosine (BM 41.440) was active in vitro against amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum in mouse peritoneal macrophages with ED50 values of 3.7 microM and 3.5 microM respectively. Ilmofosine was also active against L. donovani in BALB/c mice following oral and subcutaneous dosing, with an ED50 value of 10.5 mg/kg x 5 by the oral route.
authors.affiliation: Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Croft
authors.forename: R A
authors.initials: RA
authors.lastname: Neal
authors.forename: E A
authors.initials: EA
authors.lastname: Thornton
authors.forename: D B
authors.initials: DB
authors.lastname: Herrmann
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007279:Injections, Subcutaneous; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D010742:Phospholipid Ethers / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D010742:Phospholipid Ethers; C043297:ilmofosine