title: Cardiolipin antibodies and lupus anticoagulant in young patients with a cerebrovascular accident in the past.
abstract: To determine whether young patients who suffered a stroke in the past, have a higher prevalence of ACA of LAC as compared to healthy controls, we evaluated 44 stroke patients and 46 controls in a case-control study for the presence of ACA and LAC. All the patients had had a stroke under the age of 50 yr and the stroke date was less than 5 yr ago (mean 2.5 yr). Stroke was defined as an ischaemic cerebral infarction and was confirmed by angiography, CT-scan or MRI. An age- and sex-matched group of healthy volunteers served as controls. The mean age of the patients was 41.4 yr (range 22-52 yr), and of the controls 36.8 yr (range 24-50 yr). Serum and plasma from both groups was examined for IgM- and IgG-ACA and LAC. One patient was positive for both IgG- and IgM-ACA, whereas 3 controls were found positive for IgG-ACA. For 2 patients and 5 controls an equivocal result was obtained for IgG-ACA or IgM-ACA. None of the patients or controls were positive for LAC. The differences between the patient and control group were statistically not significant. In conclusion, no difference was found in the prevalence of cardiolipin antibodies in sera from patients with a stroke within the last 5 yr and an age- and sex-matched control group. There was no correlation either between the presence of lupus anticoagulant and the occurrence of a stroke in the past.
authors.affiliation: Department of Rehabilitation, Reinier de Graaf Gasthuis, Delft, Netherlands.
authors.forename: A W
authors.initials: AW
authors.lastname: de Jong
authors.forename: W
authors.initials: W
authors.lastname: Hart
authors.forename: M
authors.initials: M
authors.lastname: Terburg
authors.forename: J L
authors.initials: JL
authors.lastname: Molenaar
authors.forename: P
authors.initials: P
authors.lastname: Herbrink
authors.forename: W C
authors.initials: WC
authors.lastname: Hop
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016682:Lupus Coagulation Inhibitor / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor