[Application of monoclonal antibody for cancer therapy].
Immunoconjugates composed of mouse monoclonal antibody and anticancer drug was applied for the treatment of patients with colorectal cancer. Administration of mouse antibody raised human anti-mouse antibody that may interfere with the effect of immunoconjugates. To resolve this problem, human/mouse chimeric antibody was prepared and immunoconjugate of chimeric antibody and anticancer drug was developed. The characteristics of this new immunoconjugate were described.
Yamaguchi
T
T
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Takahashi
T
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000628:therapy*; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D051379:Mice; D009353:Zinostatin / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D009353:Zinostatin