Linkage analysis in a large pedigree ascertained due to essential familial hypercholesterolemia.
Sib-pair linkage analysis was used to screen a large pedigree, ascertained through four members with hypercholesterolemia, for evidence of linkage between 12 quantitative traits and 15 genetic marker loci. Traits were analyzed on the untransformed, natural log and square root-transformed scales. After adjusting for multiple tests, there is a suggestion of linkage between height and the Kidd blood group on chromosome 18 and between VLDL cholesterol, and possibly triglyceride, and KM on chromosome 2.
Bailey-Wilson
J E
JE
Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112.
Wilson
A F
AF
Bamba
V
V
D001827:Body Height; D015243:Cholesterol, VLDL / Q000235:genetics; D002887:Chromosomes, Human, Pair 18; D002889:Chromosomes, Human, Pair 2; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics*; D007667:Kidd Blood-Group System / Q000235:genetics; D008297:Male; D010375:Pedigree; D014280:Triglycerides / Q000235:genetics
D015243:Cholesterol, VLDL; D005819:Genetic Markers; D007667:Kidd Blood-Group System; D014280:Triglycerides