An immunohistochemical study of bone morphogenetic protein in pleomorphic adenoma of the salivary gland.
Bone morphogenetic protein (BMP) is a potent induction factor for new bone formation including heterotopic chondro-ossification in soft tissues. The immunohistochemical reaction for BMP was studied in 23 cases of pleomorphic adenoma of salivary gland by using a monoclonal antibody produced by hybridoma technique. Positive BMP immunoreactivity was seen in 87% of tumours. Immunohistochemical expression of BMP was observed in modified myoepithelial cells (88% cases), luminal tumour cells of tubulo-ductal structures (78% cases) and chondroid cells in hyaline tissue (22% cases). The authors concluded that the simultaneous presence of glycosaminoglycans as matrix substance with BMP-mediated cellular activity of modified myoepithelial cells in the formation of chondroid structures in pleomorphic adenomas of the salivary glands.
Lianjia
Y
Y
Department of Oral Pathology, Stomatological College of the Fourth Military Medical University, Xi'an, People's Republic of China.
Yan
J
J
Hitoshi
N
N
Shinichiro
S
S
Akihide
K
K
Masahiko
M
M
D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D019485:Bone Morphogenetic Proteins; D006801:Humans; D007150:Immunohistochemistry; D011506:Proteins / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*
D019485:Bone Morphogenetic Proteins; D011506:Proteins; D009418:S100 Proteins