[A decrease in the hydrodynamic resistance in the mesenteric arterioles of rats injected with the polyethylene oxide Polyox WSR-301].
The infusion of polyethylene oxide in anesthetised rats in a total dose of 10(-7) g/ml caused a 10-16% reduction in blood pressure. This injection has been associated with 17% decreased pressure (servo-nulling method) and 54% increased blood velocity (laser Doppler fluxmetry) in mesenteric arterioles (d - about 24 mu), but no increase in their internal diameter was observed (image-split method). Vasodilatation (adenosine, 10(-5) M) did not change the hemodynamic response of the arterioles to polymer infusion. These results suggest that microdisturbances of blood flow which can be diminished by drug-reducing polymers are more important for the vascular resistance to blood than it has been previously.
Sokolova
I A
IA
Shakhnazarov
A A
AA
Timkina
M I
MI
Poliakova
M S
MS
Priezzhev
A V
AV
Proskurin
S G
SG
Savchenko
N B
NB
Bikkulova
K F
KF
D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000502:physiology; D055592:Biophysical Phenomena; D001703:Biophysics; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000502:physiology; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects*
D011092:Polyethylene Glycols
Umen'shenie gidrodinamicheskogo soprotivleniia v arteriolakh bryzheĭki krys pri in''ektsii poliétilenoksida Polyox WSR-301.