Rapid MR imaging of a vascular challenge to focal ischemia in cat brain.
Deoxygenated blood was effectively used as a magnetic resonance (MR) susceptibility contrast agent to distinguish perfused and nonperfused (ischemic) regions in a focal ischemia model in cat brain at 2T. Modulation of cerebral blood oxygenation levels in response to apnea was followed in real time with T2*-weighted (gradient-recalled) echo-planar MR imaging. Signal loss in the T2*-weighted images occurred only in perfused tissues as blood became globally deoxygenated. These data complemented information from diffusion-weighted and contrast agent bolus-tracking images. In addition, observation of the signal recovery behavior on reventilation in both normal and ischemic brain offered potentially useful information about the state of the cerebral autoregulatory mechanism.
de Crespigny
A J
AJ
Department of Radiology, University of California, San Francisco 94143.
Wendland
M F
MF
Derugin
N
N
Vexler
Z S
ZS
Moseley
M E
ME
D000818:Animals; D002415:Cats; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D017352:Echo-Planar Imaging; D002546:Ischemic Attack, Transient / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D009942:Organometallic Compounds; D010100:Oxygen / Q000097:blood; D004369:Pentetic Acid / Q000031:analogs & derivatives
D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid; D010100:Oxygen