Interleukin-4 and the two isoforms of CD23 antigen: their possible contribution to the physiopathology of chronic lymphocytic leukemia disease.
The CD23 antigen is overexpressed and abnormally regulated in chronic lymphocytic leukemia (CLL). Interleukin-4 controls the CD23 expression, the proliferation and the longevity of the malignant B cells. These results are summarized and discussed with a view of proposing a role for these two molecules in the physiopathology of the disease. A speculative model whereby CLL would be a disease of the B cell under the control of the T cell is also presented.
Sarfati
M
M
D001402:B-Lymphocytes / Q000502:physiology; D002455:Cell Division / Q000276:immunology; D002470:Cell Survival / Q000276:immunology; D006801:Humans; D015847:Interleukin-4 / Q000502:physiology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D017455:Receptors, IgE / Q000096:biosynthesis*
D017455:Receptors, IgE; D015847:Interleukin-4