[Oxidative phosphorylation uncoupling in hyperthyroidism as a result of activating cyclosporin-sensitive pores in the inner mitochondrial membrane by water soluble modulators from rat liver cytoplasm].
Small concentrations of low molecular weight modulators of the functional state of rat liver cytoplasm mitochondria, which uncouple oxidative phosphorylation, induce phosphate-dependent transport of potassium and hydrogen ions. In contrast, high concentrations of these compounds induce nonspecific transport of monovalent cations and sucrose (K+ > H+ > Na+ > or = Li+ > sucrose). The effect of cytoplasmic modulators on oxidative phosphorylation and permeability of the inner mitochondrial membrane in inhibited by cyclosporin A and controlled by physiological concentrations of Ca2+. It is assumed that ion transport across the inner mitochondrial membrane in the presence of cytoplasmic modulators is implemented by the same cyclosporin-sensitive transport system which in damaged mitochondria functions as a nonspecific pore.
Gaĭnutdinov
M Kh
MKh
Konov
V V
VV
Ishmukhamedov
R N
RN
Zakharova
T N
TN
Khalilova
M A
MA
Asparov
M I
MI
D000818:Animals; D001692:Biological Transport; D002412:Cations; D002463:Cell Membrane Permeability / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism*; D006980:Hyperthyroidism / Q000378:metabolism*; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010085:Oxidative Phosphorylation; D051381:Rats; D012995:Solubility; D013395:Sucrose / Q000378:metabolism; D014867:Water
D002412:Cations; D014867:Water; D013395:Sucrose; D016572:Cyclosporine
Razobshchenie okislitel'nogo fosforilirovaniia pri gipertireoze kak sledstvie aktivatsii tsiklosporinchuvstvitel'noĭ pory vo vnutrenneĭ membrane mitokhondriĭ vodorastvorimymi moduliatorami iz tsitoplazmy pecheni krysy.