Transient acantholytic dermatosis induced by recombinant human interleukin 4.
BACKGROUND
Interleukin 4 is one of many cytokines under investigation about its possible role in the pathogenesis and treatment of disease. Transient acantholytic dermatosis is of uncertain origin. It has not previously been linked to drug ingestion and is generally not believed to have an immunologic basis.


OBJECTIVE
Our purpose was to describe the clinical characteristics and histologic features of a cutaneous eruption caused by interleukin 4.


METHODS
Three patients in whom an eruption developed after they received intravenous recombinant human interleukin 4 were examined and biopsy specimens were evaluated.


RESULTS
These patients had a pruritic papulovesicular eruption that was consistent, both clinically and histologically, with transient acantholytic dermatosis. None of the other conditions believed to precipitate transient acantholytic dermatosis was present in our patients.


CONCLUSIONS
This is the first report of a cutaneous side effect of interleukin 4. This may be antibody-mediated or related to increased production of tissue-type plasminogen activator.
Mahler
S J
SJ
Division of Dermatology, University of Texas Health Science Center, San Antonio 78284-7876.
De Villez
R L
RL
Pulitzer
D R
DR
D000051:Acantholysis / Q000209:etiology* / Q000473:pathology; D000368:Aged; D006801:Humans; D015847:Interleukin-4 / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects
D011994:Recombinant Proteins; D015847:Interleukin-4