Congenital nystagmus cosegregating with a balanced 7;15 translocation.
We report a family in which autosomal dominant congenital nystagmus cosegregates with a balanced 7;15 translocation. Ophthalmic investigation showed predominantly horizontal nystagmus with a small rotatory component and no significant loss of visual function. This finding suggests a possible localisation for autosomal dominant congenital nystagmus (McKusick 164100).
Patton
M A
MA
South West Thames Regional Genetic Service, St George's Hospital Medical School, London, UK.
Jeffery
S
S
Lee
N
N
Hogg
C
C
D002884:Chromosomes, Human, Pair 15; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D009759:Nystagmus, Pathologic / Q000151:congenital* / Q000235:genetics*; D010375:Pedigree; D014178:Translocation, Genetic