[Morphological changes in the pituitary gland and ovary in testosterone-induced anovulatory rat treated with Chinese medicinal herbs].
Injection of testosterone propionate 1.25 mg were given to SD rats on 9 days of age, and fed with replenishing Kidney herbal decoction as well as with distilled water as control from 80 to 94 days of age. On 100 days of age, all the rats were sacrificed and the pituitary glands and ovaries were excised for examination. In the ovaries, increase in interstitial glands' count and lowering of lipid drop's quantity in cytoplasm of interstitial glandular cells were observed after the treatment, and intracellular "crinophagy" and "autophagy" disappeared in the pituitary gland. After treatment with replenishing Kidney drugs, ovarian estrogen receptors increased whereas the ovarian progesterone receptors raised even higher. It suggests that both ovaries and pituitary gland in testosterone induced anovulatory rats were affected by herbs of replenishing Kidney.
Wei
M J
MJ
Obstetrics and Gynecology Hospital, Shanghai Medical University.
Yu
J
J
D000818:Animals; D000858:Anovulation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D010053:Ovary / Q000648:ultrastructure*; D010902:Pituitary Gland / Q000648:ultrastructure*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D013739:Testosterone; D014626:Vaginal Smears
D004365:Drugs, Chinese Herbal; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013739:Testosterone