title: Results of surgical treatment for growth hormone-secreting pituitary adenomas.
abstract: The results of surgical therapy for acromegaly were reviewed in a series of 175 patients treated between 1972 and 1983. Patients with prior surgery or radiation therapy were excluded from the study. Postoperative radiation therapy was given to 54 patients. The criterion of achieving a postoperative basal or glucose-suppressed growth hormone level of 2 ng/ml or less was used to indicate remission. Utilizing the most recently available growth hormone determinations, 90 (51.7%) of 174 patients were in remission. The actuarial probability of remission at 1 and 5 years after surgery was 48.8% and 62.7%, respectively. Tumor size and the preoperative basal growth hormone level were correlated with outcome. Surgical excision of a pituitary adenoma is the most effective therapy currently available for acromegaly.
authors.affiliation: Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
authors.forename: D H
authors.initials: DH
authors.lastname: Davis
authors.forename: E R
authors.initials: ER
authors.lastname: Laws
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
authors.forename: J K
authors.initials: JK
authors.lastname: Speed
authors.forename: M
authors.initials: M
authors.lastname: Caruso
authors.forename: E G
authors.initials: EG
authors.lastname: Shaw
authors.forename: C F
authors.initials: CF
authors.lastname: Abboud
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: L M
authors.initials: LM
authors.lastname: Root
authors.forename: C
authors.initials: C
authors.lastname: Schleck
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000601:surgery*; D011183:Postoperative Complications; D011336:Probability; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D013006:Growth Hormone