title: Efficacy of continuous intercostal bupivacaine for pain relief after thoracotomy.
abstract: We studied 20 patients undergoing thoracotomy, in a double-blind, placebo-controlled crossover trial of intercostal bupivacaine. Bupivacaine 0.25% was infused at 5 ml h-1 through each of two catheters placed in the intercostal space at operation. Mean (95% confidence limits) 24-h requirements for morphine from a patient-controlled analgesia device were 29 (22-37) mg during bupivacaine infusion and 44 (32-57) mg during saline infusion (P = 0.04). Patients also recorded significantly smaller visual analogue scores for pain during bupivacaine infusion. There were no adverse effects related to the intercostal infusion of bupivacaine. We conclude that bupivacaine, infused through catheters placed during thoracotomy in the adjacent intercostal spaces, is a useful adjunct to systemic opioid analgesia.
authors.affiliation: Department of Anaesthetics, Western Infirmary, Glasgow.
authors.forename: C M
authors.initials: CM
authors.lastname: Dryden
authors.forename: I
authors.initials: I
authors.lastname: McMenemin
authors.forename: D J
authors.initials: DJ
authors.lastname: Duthie
mesh_terms: D000368:Aged; D016058:Analgesia, Patient-Controlled; D002045:Bupivacaine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D013908:Thoracotomy
chemical_list: D009020:Morphine; D002045:Bupivacaine