CSF cholecystokinin octapeptide in patients with bulimia nervosa and in normal comparison subjects.
Cholecystokinin octapeptide (CCK-8) appears to modulate appetitive behavior, and in rodents, anxiety-related behavior. The authors studied CCK-8 in patients with bulimia nervosa. CSF concentrations of CCK-8 were measured in 11 drug-free female patients with DSM-III-R-defined bulimia nervosa and in 16 normal subjects. The bulimic patients had significantly lower levels of CCK-8 than the comparison subjects. CCK-8 concentrations were inversely correlated with scores on the anger-hostility, anxiety, and interpersonal sensitivity subscales of the SCL-90-R. They were not significantly correlated with age, percentage of standardized average body weight, or mean weekly frequency of binge eating or vomiting. The results indicate that central CCK-8 abnormalities may play a role in the pathophysiology of bulimia nervosa.
Lydiard
R B
RB
Institute of Psychiatry, Medical University of South Carolina, Charleston 29425.
Brewerton
T D
TD
Fossey
M D
MD
Laraia
M T
MT
Stuart
G
G
Beinfeld
M C
MC
Ballenger
J C
JC
D000328:Adult; D000367:Age Factors; D001835:Body Weight; D002032:Bulimia / Q000134:cerebrospinal fluid* / Q000503:physiopathology / Q000523:psychology; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000502:physiology; D012737:Sex Factors; D012844:Sincalide / Q000134:cerebrospinal fluid* / Q000502:physiology
D012701:Serotonin; D012844:Sincalide