title: The effect of spermine on the disaccharidase activities in suckling rats of different age.
abstract: The influence of the age of the rat on the maturation of disaccharidase activities induced by spermine was studied. Three-day- and 9-day-old rats were used in the experiment. Spermine was administered orally or directly into the stomach using thin tubing daily for 3 days, and disaccharidase activities in the jejunum were measured. While spermine caused maturation of not only lactase activity but also maltase and sucrase activities in 9-day-old rats, it only caused maturation of lactase activity in 3-day-old rats. Histological studies showed no significant changes in the jejunum of 3-day-old rats treated with spermine.
authors.affiliation: Department of Pediatrics, Osaka University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Mushiake
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Okada
mesh_terms: D000367:Age Factors; D000818:Animals; D000833:Animals, Suckling; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D007583:Jejunum / Q000187:drug effects / Q000201:enzymology*; D043322:Lactase; D051381:Rats; D017207:Rats, Sprague-Dawley; D013096:Spermine / Q000494:pharmacology*; D013393:Sucrase / Q000096:biosynthesis*; D000520:alpha-Glucosidases / Q000096:biosynthesis*; D001616:beta-Galactosidase / Q000096:biosynthesis*
chemical_list: D013096:Spermine; D043322:Lactase; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D013393:Sucrase