[The effect of corticosteroid on the repair of the retinal pigment epithelium].
The effect of corticosteroid on the repairing process of the retinal pigment epithelial cells (RPE) after laser photocoagulation was investigated. Mild-intensity krypton red laser photocoagulations were performed on the monkey retina. After laser photocoagulations, betamethasone (0.5 mg/kg) were administered intramuscularly every day for 1-14 days. Moreover, the same doses of betamethasone were also administered intramuscularly for one week from the 1st to 7th day after laser photocoagulation on other monkeys. The photocoagulated lesions were observed with light and transmission electron microscopy. In monkeys that received corticosteroids, the migration and the proliferation of RPE were markedly inhibited, and the metaplasia to fibroblast-like cells of RPE was not observed. These results showed that large doses of corticosteroid inhibited the repair process of the injured RPE.
Kishimoto
N
N
Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
Uyama
M
M
Fukushima
I
I
Yamada
K
K
Nishikawa
M
M
Ohkuma
H
H
D000818:Animals; D001623:Betamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D007273:Injections, Intramuscular; D017075:Laser Coagulation; D008252:Macaca fascicularis; D008854:Microscopy, Electron; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D014945:Wound Healing / Q000187:drug effects*
D001623:Betamethasone