[The NADP.H-cytochrome C reductase and aldose reductase activities in the retina, cerebral cortex and liver of healthy rats and of those with hereditary retinal degeneration in the early postnatal development period].
Maximal activity of NADP.H-cytochrome c reductase was found in the liver, the lowest one--in the retina. On the contrary, the highest activity of aldose reductase was observed in the retina, the lowest one--in the liver. The activity of NADP.H-cytochrome c reductase in the retina of rats with hereditary degeneration of the retina increased to the 60th day of postnatal life by 33%, the increase reaching 273% to the 90th day. In the brain cortex, the increase in the activity to the 45-60th days amounted to 22-34%, whereas at the age of 90 days the difference between healthy and patient rats, as well as the difference between males and females became less significant. The activity of aldose reductase in the cortex and retina in patient rats at the 20th day was 35% lower than in healthy animals. In the liver of patient rats, to the age of 45 days, the activity of aldose reductase decreased by 38%. At other periods, no significant differences were observed between healthy and patient animals with respect to the activity of this enzyme.
Shushakova
N D
ND
Rychkova
M P
MP
Efimova
M G
MG
D000375:Aging / Q000378:metabolism; D000449:Aldehyde Reductase / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology*; D005260:Female; D008099:Liver / Q000201:enzymology*; D008297:Male; D008861:Microsomes / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012160:Retina / Q000201:enzymology*; D012162:Retinal Degeneration / Q000201:enzymology*
D000449:Aldehyde Reductase; D009251:NADPH-Ferrihemoprotein Reductase
Aktivnost' NADF.H-tsditokhrom C reduktazy i al'dozoreduktazy v setchatke, kore golovnogo mozga i pecheni zdorovykh i bol'nykh nasledstvennoĭ degeneratsieĭ setchatki krys v ranniĭ period postnatal'nogo razvitiia.