title: [Antepartum diagnosis of pseudohypertrophic muscular dystrophy using 14 sets of primers].
abstract: We used fourteen sets of primers to detect the gene deletion of 27 clinically diagnosed DMD patients by multiplex PCR technic. The detection rate was 59%. We found that the deletion region was more concentrated in the region of exon 43 to 52. The data was discussed. Twenty-two mothers of the twenty-seven affected children were pregnant again, and prenatal diagnosis was done by multiplex PCR of the DNA of the chorionic villi. Four affected fetuses were found and aborted.
authors.affiliation: Peking Union Medical College Hospital, Beijing.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
mesh_terms: D002648:Child; D002675:Child, Preschool; D015193:Chorionic Villi Sampling; D005091:Exons; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics; D017353:Gene Deletion; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000175:diagnosis* / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D011296:Prenatal Diagnosis