[Synthesis of furo(2,3-b)pyridine amidines with antianaphylactic activity].
The synthesis of furo[2,3-b]pyridine formamidines (D/1-D/11, F) was realized by the reaction of the 3-amino-furo[2,3-b]pyridines C/1-C/11 and E, substituted in position 2 with a carbonyl moiety with dimethylformamide/phosphoroxide chloride or with N-formyl-piperidine or N-formyl-morpholine and phosphoroxide chloride. The acetamidines H were yielded from 4-oxo-4H-3-methyl-pyrido[3',2':4,5]furo[3,2-d]1,3-oxazines with aminoethanol. The 4-oxo-4H-3-amino-3,4-dihydro-pyrido[3',2':4,5]furo[3,2-d]pyrimidines K and M reacted with dimethylformamide/phosphoroxide chloride to give the tricyclic formamidines L and K. The described amidines showed antianaphylactic activity.
Wagner
G
G
Fachbereich Biowissenschaften, Universität Leipzig.
Prantz
J
J
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000578:Amidines; D016859:Lipoxygenase Inhibitors; D011725:Pyridines
Synthese von Furo[2,3-b]pyridin-amidinen mit antianaphylaktischer Wirkung.