Amino acids and peptides. XVIII. Synthetic peptides related to N-terminal portion of fibrin alpha-chain and their inhibitory effect on fibrinogen/thrombin clotting.
Peptide analogs of the N-terminal portion of fibrin alpha-chain were prepared and their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, H-Gly-Pro-Arg-Pro-Pro-NH2 exhibited the most potent inhibitory effect.
Kawasaki
K
K
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Miyano
M
M
Hirase
K
K
Iwamoto
M
M
D000595:Amino Acid Sequence; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology*; D005337:Fibrin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005340:Fibrinogen / Q000037:antagonists & inhibitors; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors
D000925:Anticoagulants; D009842:Oligopeptides; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin