[The compensatory-adaptive mechanisms in nitrite-induced hypoxia in rats].
Concentration of blood proteins, alpha-amino nitrogen, cGMP and endothelin-1,2 was studied in rat's blood at nitric hypoxia. The injection of NaNO2 (5 mg/100 g body weight) was followed by decrease in total protein, albumin and hemoglobin content and by sharp increase in methemoglobin and Hb-NO complexes concentration in rat's blood. Simultaneously, the elevation of free amino acids and peptides with m.w. 2500 D in blood was discovered. One of these peptides was the endothelin-1,2, whose concentration increased twice in plasma at nitric hypoxia. The increase in endothelin and cGMP concentrations is mostly linked with activation of compensative mechanisms, arising as a response to high concentrations of nitro compounds and NO in rats.
Reutov
V P
VP
Sorokina
E G
EG
Pinelis
V G
VG
Korshunova
T S
TS
Rodionov
A A
AA
Koshelev
V B
VB
Strukova
S M
SM
Kaiushin
L P
LP
Braquet
P
P
Komissarova
L Kh
LKh
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000097:blood; D004578:Electron Spin Resonance Spectroscopy; D016232:Endothelins / Q000097:blood / Q000187:drug effects; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000494:pharmacology*
D001798:Blood Proteins; D016232:Endothelins; D006152:Cyclic GMP; D012977:Sodium Nitrite
Kompensatorno-prisposobitel'nye mekhanizmy pri nitritnoĭ gipoksii u krys.