Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment.
Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of 14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxy-eicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score.
Zijlstra
F J
FJ
Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands.
van Dijk
A P
AP
Ouwendijk
R J
RJ
van Riemsdijk-Overbeeke
I C
IC
Wilson
J H
JH
D000636:Aminosalicylic Acids / Q000494:pharmacology*; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000378:metabolism*; D015777:Eicosanoids / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D015289:Leukotrienes / Q000096:biosynthesis; D008297:Male; D019804:Mesalamine; D011453:Prostaglandins / Q000096:biosynthesis
D000636:Aminosalicylic Acids; D015777:Eicosanoids; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D011453:Prostaglandins; D019804:Mesalamine