title: Cholesterolosis in patients with chronic acalculous biliary pain.
abstract: The outcome of patients with cholesterolosis was compared with that of those with chronic cholecystitis operated on for chronic acalculous biliary pain. A total of 55 patients with acalculous biliary pain with a median symptom duration of 24 (range 6-120) months were investigated by dynamic cholescintigraphy and followed for a median of 24 (range 12-60) months. Thirty-five patients underwent cholecystectomy, of whom 22 had a low gallbladder ejection fraction (under 35 per cent), with symptomatic improvement in 21 of these (P < 0.01). All four patients with a normal ejection fraction (35-50 per cent) improved after cholecystectomy but only four of nine with a high ejection fraction (over 50 per cent) did so. Results of histological examination were available in 32 patients and revealed cholesterolosis in 20. A low ejection fraction was found in 16 patients with cholesterolosis, of whom 15 showed symptomatic improvement after cholecystectomy; the other four patients had a high fraction and all improved after cholecystectomy. Overall, symptoms in 19 of 20 patients with cholesterolosis improved after cholecystectomy compared with only seven of 12 with chronic cholecystitis (P = 0.03).
authors.affiliation: Department of Surgery, Dudley Road Hospital, Birmingham, UK.
authors.forename: W A
authors.initials: WA
authors.lastname: Kmiot
authors.forename: E P
authors.initials: EP
authors.lastname: Perry
authors.forename: I A
authors.initials: IA
authors.lastname: Donovan
authors.forename: M J
authors.initials: MJ
authors.lastname: Lee
authors.forename: R F
authors.initials: RF
authors.lastname: Wolverson
authors.forename: L K
authors.initials: LK
authors.lastname: Harding
authors.forename: J P
authors.initials: JP
authors.lastname: Neoptolemos
mesh_terms: D000328:Adult; D000368:Aged; D001659:Biliary Tract / Q000000981:diagnostic imaging / Q000378:metabolism; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D002763:Cholecystectomy; D002784:Cholesterol / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D011379:Prognosis; D011877:Radionuclide Imaging
chemical_list: D002784:Cholesterol