title: [The pharmacological properties of coenzyme A disulfide].
abstract: Coenzyme A disulfide (CoA disulfide) was pharmacologically studied. It has been found to normalize lipid and carbohydrate metabolism when given in a dose of 2 mg/kg, i.m., in diverse liver dysfunctions. It possesses an antihypoxic action under hemic and histotoxic hypoxia. When given in small doses (80-160 micrograms/kg, i.v.), CoA disulfide depresses the function of cellular hemostasis.
authors.forename: V M
authors.initials: VM
authors.lastname: Avakumov
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Krylov
authors.forename: A L
authors.initials: AL
authors.lastname: Karaev
authors.forename: A G
authors.initials: AG
authors.lastname: Muliar
authors.forename: T N
authors.initials: TN
authors.lastname: Smirnova
authors.forename: M A
authors.initials: MA
authors.lastname: Kovler
authors.forename: E A
authors.initials: EA
authors.lastname: Filina
mesh_terms: D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism; D003065:Coenzyme A / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006487:Hemostasis / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy / Q000378:metabolism; D011488:Protein Deficiency / Q000188:drug therapy / Q000378:metabolism; D051381:Rats
chemical_list: C017145:coenzyme A disulfide; D003065:Coenzyme A
vernacular_title: Farmakologicheskie svoĭstva kofermenta A-disulfida.