title: Malignant pleural mesothelioma. Multivariate analysis of prognostic factors on 113 patients.
abstract: We report on clinical features of 113 cases of pathologically confirmed Malignant Pleural Mesothelioma, observed in Genoa (Italy) between 1979 and 1985. Overall median survival was 10 months. Among the pretreatment variables studied (age, sex, asbestos exposure, pathological type, chest pain and dyspnea at the time of diagnosis), the only one of prognostic value in the univariate analysis was the histological subtype: median survivals were 12, 7 and 4 months for the patients in the epithelial, mixed, and fibrosarcomatous groups, respectively (p = 0.0012). A multivariate analysis confirmed the independent predictive power of the histotype (p = 0.0022). A review of literature data concerning prognostic factors in Malignant Pleural Mesothelioma is presented.
authors.affiliation: Division of Medical Oncology, Istituto Nazionale per la Ricera sul Sancro, Genoa, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Fusco
authors.forename: A
authors.initials: A
authors.lastname: Ardizzoni
authors.forename: F
authors.initials: F
authors.lastname: Merlo
authors.forename: A
authors.initials: A
authors.lastname: Cinquegrana
authors.forename: B
authors.initials: B
authors.lastname: Faravelli
authors.forename: M
authors.initials: M
authors.lastname: De Palma
authors.forename: L
authors.initials: L
authors.lastname: Chessa
authors.forename: G
authors.initials: G
authors.lastname: Nicolò
authors.forename: M
authors.initials: M
authors.lastname: Serra
authors.forename: A
authors.initials: A
authors.lastname: Capaccio
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001194:Asbestos / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008654:Mesothelioma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D015999:Multivariate Analysis; D010997:Pleural Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012737:Sex Factors; D016019:Survival Analysis
chemical_list: D001194:Asbestos