Enhancement of susceptibility of CB-17 mice to systemic candidiasis by poly(I . C)-induced interferon.
Poly(I . C) enhanced the susceptibility of CB-17 (BALB/c) mice to acute systemic candidiasis. Poly(I . C), supernatants from poly(I . C)-treated macrophages, or alpha and beta interferons suppressed macrophage candidacidal activity in vitro. Thus, poly(I . C)-induced interferons may enhance the susceptibility of CB-17 mice to candidiasis by suppressing macrophage candidacidal activity in an autocrine fashion.
Jensen
J
J
Department of Surgery, University of Wisconsin Medical School, Madison 53706.
Balish
E
E
D000818:Animals; D002177:Candidiasis / Q000276:immunology*; D004198:Disease Susceptibility; D016898:Interferon-alpha / Q000502:physiology*; D016899:Interferon-beta / Q000502:physiology*; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology*
D016898:Interferon-alpha; D016899:Interferon-beta; D011070:Poly I-C