Stereologic studies on the long-term effect of prazosin on rat adrenal cortex.
Adult female rats were treated with prazosin, a selective alpha 1-adrenoceptor inhibitor, for 60 days in doses of 0.5 mg/kg/day or 0.5 mg/kg/8 h. Prolonged prazosin administration lowered the gain of body weight and significantly decreased systolic blood pressure and heart weight. Prazosin administered every 8 h also lowered serum triglycerides but did not change the total cholesterol level. Selective alpha 1-inhibitor treatment increased the adrenal gland weight and decreased the number of adrenocortical cells; in every 8 h treated group this effect being connected with a marked cell hypertrophy (in all adrenocortical zones). Our results suggest that prazosin induced changes in the structure of the rat adrenal cortex depend on activation of the hypothalamo-pituitary-adrenocortical axis and possibly on the small inhibition of the proliferative activity of rat adrenocortical cells.
Stachowiak
A
A
School of Medicine, Department of Histology and Embryology, Poznán, Poland.
Malendowicz
L K
LK
D000302:Adrenal Cortex / Q000187:drug effects / Q000473:pathology*; D000818:Animals; D005260:Female; D006984:Hypertrophy / Q000139:chemically induced / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D011224:Prazosin