title: [Biotransformation and excretion of Z-2-amino-5-chlorobenzophenoneamidinohydrazone].
abstract: After i.v., p.o. and i.p. administration of 14C-labeled Z-2-amino-5-chlorobenzophenoneamidinohydrazone (1) to male Wistar rats the total radioactivity is mainly excreted via faeces (80%). Within 3 to 4 d after administration 86 to 100% of the dose have been found in urine and faeces. Beside 1 and its E-isomer (2) we have detected in faeces of rats and rabbits the metabolites 3 (principal metabolite) and 4, in urine of rats additionally 5 and 6, and in urine of rabbits additionally 5 to 8. With regard to the results of high resolution mass spectrometry, UV, TLC and the hydrolyzability using beta-glucuronidase we can conclude that 3 and 4 are metabolites position isomerically hydroxylated at the unsubstituted phenyl group, 5 and 6 are the glucuronides of them, and 7 and 8 are the glucuronides of 1 and 2.
authors.affiliation: Fachbereich Pharmazie, Humboldt-Universität zu Berlin.
authors.forename: H H
authors.initials: HH
authors.lastname: Borchert
authors.forename: A
authors.initials: A
authors.lastname: Schieweck
authors.forename: P
authors.initials: P
authors.lastname: Franke
authors.forename: U
authors.initials: U
authors.lastname: Morgenroth
authors.forename: U
authors.initials: U
authors.lastname: Joram
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001577:Benzophenones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D006835:Hydrazones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000889:Anti-Arrhythmia Agents; D001577:Benzophenones; D006835:Hydrazones; C080444:(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate
vernacular_title: Biotransformation und Ausscheidung von Z-2-Amino-5-chlorbenzophenonamidinohydrazon.