[Intraocular penetration of current antibiotics].
We studied the intraocular penetration of 42 antibiotics in white rabbit eyes between 1980 to 1990 in our department. The parenteral route (intravenous, intramuscular): the ratios of maximum aqueous humor to serum level were 5.28-11.6% in penicillins (PCs), 5.95-20.17% in cephems and 13.4-30.27% in aminoglycosides (AGs). The aqueous concentration of antibiotics reached a peak within 1/4-1 hour after injection. Oral administration: the ratios of aqueous to serum level were 8.52-20.6% in PCs, 3.62-20.11% in cephems, 22.8-75.8% in macrolides (MLs) and 6.38-23.6% in quinolones. The aqueous concentration of antibiotics reached a peak within 1-4 hours after oral administration. The ratio of aqueous to serum level was the highest in MLs. The aqueous level reached a peak faster and the ratio of aqueous to serum level was higher by injection than by oral administration.
Miyao
M
M
Department of Ophthalmology, Niigata University School of Medicine, Niigata Cancer Center Hospital, Japan.
Tazawa
H
H
Motoyama
M
M
Suzuki
A
A
Ooishi
M
M
D000284:Administration, Oral; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D010406:Penicillins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins