title: Treatment of massive pulmonary embolism with centrally administered tissue-type plasminogen activator.
abstract: We report the use of centrally administered tissue-type plasminogen activator for three patients who presented with massive pulmonary embolism to the emergency department. In all patients, rapid improvement of pulmonary arterial pressures ensued by the end of the drug infusion, while the presenting symptoms of chest pain and shortness of breath subsided.
authors.affiliation: Department of Internal Medicine, South Chicago Community Hospital.
authors.forename: S K
authors.initials: SK
authors.lastname: Mohindra
authors.forename: G O
authors.initials: GO
authors.lastname: Udeani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004630:Emergencies; D005260:Female; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000188:drug therapy* / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator