[Effect of Japanese Ganoderma Lucidum on production of interleukin-2 from murine splenocytes].
The purpose of this study was to determine the effect of Ganoderma lucidum (GL) planted in Japan on the production of Interleukin-2 (IL-2) from murine splenocytes. It was observed that hydrocortisone (HC) 0.025-1 microgram /ml could significantly antagonize the inhibitory activity of HC and CSA to increase the production of IL-2 in vitro, P < 0.01. When the splenocytes pretreated with GL alone or in combination with HC, it was shown that pretreatment alone had no significant effect on IL-2 production, but preincubating splenocytes with HC and GL resulted in a significant increase of IL-2 production when compared with that of HC group, P < 0.01. In vivo, GL 300 mg/kg could increase the production of IL-2 when oral taken GL alone or in combination of HC.
Zhang
L X
LX
School of Pharmacy, Shanghai Medical University.
Mong
H
H
Zhou
X B
XB
D000818:Animals; D002478:Cells, Cultured; D016572:Cyclosporine; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D016867:Immunocompromised Host / Q000187:drug effects*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D016572:Cyclosporine