title: [Digoxin intoxication due to unadjusted loading dose in renal failure].
abstract: We describe a case of digoxin intoxication due to an unadjusted loading dose in a patient with renal failure. The importance of individual calculation of the digoxin dosing regimen in patients with renal failure is reemphasized. The volume of distribution of digoxin decreases significantly in chronic renal failure, due to decreased tissue binding in the uremic state. Accordingly, not only the digoxin maintenance dose, but the digoxin loading dose as well must be adjusted in this condition.
authors.affiliation: Clinical Pharmacology Unit, Chaim Sheba Medical Center, Tel Hashomer.
authors.forename: H
authors.initials: H
authors.lastname: Seligmann
authors.forename: D
authors.initials: D
authors.lastname: Ezra
mesh_terms: D000368:Aged; D004077:Digoxin / Q000008:administration & dosage / Q000378:metabolism / Q000506:poisoning*; D005260:Female; D006801:Humans; D051437:Renal Insufficiency / Q000150:complications* / Q000378:metabolism
chemical_list: D004077:Digoxin