title: Limb salvage surgery for locally aggressive and malignant bone tumors.
abstract: Since 1983, 77 patients have had limb salvage surgery for locally aggressive or malignant bone tumor of the limbs or pelvis. Twenty-nine patients had locally aggressive lesions with giant cell tumors the most prevalent, and 48 patients had malignant lesions, of which osteosarcomas predominated. Resection with a wide margin could be achieved in most of the patients. A mobile joint reconstruction was performed in 57 patients and an arthrodesis in 14 patients. At follow-up, 14 patients have died of disease, 7 patients have survived with disease, and 56 patients (73%) have survived without disease. Local recurrences were encountered in 4 patients (5%). The overall functional results were classified as excellent in 11 patients, good in 45 patients, and fair in 9 patients. Twelve patients had poor results because of failure of the reconstruction or amputation due to complications. Twenty-seven complications were encountered, among which infection was the most serious. Careful selection of patients and consideration of procedure chosen to reconstruct the defect are important for a successful outcome. This decision is based on a number of factors related to the tumor and the patient. Presently, major neurovascular involvement, displaced pathological fracture, inappropriate biopsy incision, extreme youth of the patient, and infection were considered to be contraindications to resection in our institution. Although various procedures promise functional restoration, the reconstructive procedure should be individualized and designed to meet the needs of the patient.
authors.affiliation: Department of Orthopedics and Traumatology, Veterans General Hospital-Taipei, Taiwan, Republic of China.
authors.forename: L Y
authors.initials: LY
authors.lastname: Shih
authors.forename: T S
authors.initials: TS
authors.lastname: Chen
authors.forename: W H
authors.initials: WH
authors.lastname: Lo
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000401:mortality / Q000601:surgery*; D016025:Bone Transplantation; D017024:Chemotherapy, Adjuvant; D005260:Female; D005266:Femoral Neoplasms / Q000401:mortality / Q000601:surgery*; D005870:Giant Cell Tumors / Q000401:mortality / Q000601:surgery; D006801:Humans; D006811:Humerus / Q000601:surgery*; D007595:Joint Prosthesis; D015993:Life Tables; D008297:Male; D012516:Osteosarcoma / Q000401:mortality / Q000601:surgery; D011884:Radius / Q000601:surgery*; D013977:Tibia / Q000601:surgery*