Severe phenytoin-induced bone marrow depression and agranulocytosis treated with human recombinant granulocyte-macrophage colony-stimulating factor. Case report.
An unusual instance of severe and potentially lethal depression of the bone marrow is described as a result of the administration of phenytoin for seizure prophylaxis. The patient was treated successfully by prompt cessation of phenytoin and intravenous administration of human recombinant granulocyte-macrophage colony-stimulating factor.
Rawanduzy
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A
Department of Neurological Surgery, St. Vincent's Hospital and Medical Center of New York, New York.
Sarkis
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A
Rovit
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RL
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy*; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D011994:Recombinant Proteins; D012640:Seizures / Q000517:prevention & control
D011994:Recombinant Proteins; D010672:Phenytoin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor