Combination of amorolfine with various antifungal drugs in dermatophytosis.
The fungistatic activity of ketoconazole, griseofulvin and terbinafine alone and in combination with amorolfine was tested in casitone agar. The fungistatic activity of all three against Trichophyton mentagrophytes is slightly increased by the addition of amorolfine. In yeasts the results are not so clear. The combinations of amorolfine with griseofulvin, terbinafine, itraconazole and fluconazole were always more efficient in a murine model of dermatophytosis than the monotherapy, thus a clear synergism between amorolfine and other antifungals was seen.
Polak
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A
F. Hoffmann-La Roche Ltd, Pharma Division, Basel, Switzerland.
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy*; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D051379:Mice; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000627:therapeutic use*
D000935:Antifungal Agents; D009025:Morpholines; C038974:amorolfine