Physical properties of VNTR data, and their impact on a test of allelic independence.
In this article we describe the physical properties of VNTR data, as well as their effects on the two-dimensional distribution of fragment pairs. Tests of independence of alleles at a locus may confound those physical properties with allele independence. A recently proposed test by Geisser and Johnson is an example. We show that alleles can be strictly independent, yet the proposed test suggests large violations of allele independence because it is sensitive to well-known electrophoretic phenomena.
Devlin
B
B
Department of Epidemiology and Public Health, Yale University, New Haven, CT 06510.
Risch
N
N
D000483:Alleles; D016009:Chi-Square Distribution; D004247:DNA / Q000032:analysis; D016172:DNA Fingerprinting; D004587:Electrophoresis, Agar Gel; D005554:Forensic Medicine; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D008957:Models, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D015203:Reproducibility of Results
D004247:DNA