title: Indices of adequate dialysis in patients hemodialyzed with AN 69 membrane.
abstract: The objective of this study was to evaluate the incidence of morbidity (at least one hospitalization) during the first twelve months of hemodialysis (thrice weekly for 4 hours) in 54 (27 males and 27 females) sex and age matched patients, of whom 32 were treated with AN 69 (M/F = 13/19, 62 +/- 14 years) and 22 with Cuprophan (M/F = 14/8, 61 +/- 14 years). Patients were classified according to the value of TAC urea during the period under study: constantly superior or equal to 20 mmol/liter in Group A (high TAC urea) or inferior to 20 mmol/liter in Group B (low TAC urea). Dialysis quantification (Kt/V) and estimation of the patient's protein catabolic rate (PCR) were based on measurement of the midweek pre- and post-dialysis blood urea nitrogen. In the patients of Group B, incidence of morbidity was significantly increased when age was over 50 years and when AN 69 membrane was used (P < 0.02). Furthermore, in Group A, the risk of hospitalization was significantly higher in patients treated by Cuprophan than in those treated by AN 69 (P < 0.02). The survival rate was also studied. Better survival (70%) at four years was observed in patients with high TAC urea who were treated by AN 69. The difference was highly significant with the survival rate (22%) in patients with high TAC urea who were treated by Cuprophan (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service de Néphrologie, Hôpital La Beauchée, Saint-Brieuc, France.
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: K S
authors.initials: KS
authors.lastname: Ang
authors.forename: G
authors.initials: G
authors.lastname: Cam
authors.forename: A
authors.initials: A
authors.lastname: Benziane
authors.forename: F
authors.initials: F
authors.lastname: Bonn
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009748:Nutrition Disorders / Q000150:complications; D006435:Renal Dialysis / Q000401:mortality*; D015996:Survival Rate
chemical_list: D008567:Membranes, Artificial