title: Heterogeneity of centronuclear myopathy shown by flow cytometry of nuclear DNA.
abstract: Determination of nuclear DNA by flow cytometry of skeletal muscle biopsies of three unrelated male patients with centronuclear (myotubular) myopathy demonstrated, in two patients, a normal pattern and, in one case, a near haploid DNA content in c. 60% of all nuclei, indicating muscle tissue mosaicism.
authors.affiliation: Institute of Neuropathology Bethel, Bielefeld, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Metze
authors.forename: R
authors.initials: R
authors.lastname: Schnabel
authors.forename: W
authors.initials: W
authors.lastname: Mellin
authors.forename: F
authors.initials: F
authors.lastname: Gullotta
authors.forename: W
authors.initials: W
authors.lastname: Hiddemann
mesh_terms: D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure*; D004247:DNA / Q000378:metabolism*; D005434:Flow Cytometry; D006238:Haploidy; D006801:Humans; D007223:Infant; D008297:Male; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology*
chemical_list: D004247:DNA