title: [Clinical study of imipenem/cilastatin sodium in serious infections in critical care medical center].
abstract: Patients with severe trauma and illness were treated at our critical care medical center. Many of these patients have diabetes, anemia and other underlying conditions which sometimes lead to serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA) or Pseudomonas aeruginosa. A clinical study imipenem/cilastatin sodium (IPM/CS) was performed at our Medical Center. IPM/CS was administered to 30 patients with serious infections. Clinical results were excellent in 11, good in 5, fair in 9 and poor in 5 patients, thus an overall efficacy rate of 53.3% was obtained. Bacteriological efficacy rate was 50% with eradications in 11 cases and decreases in 3 cases out of 28 cases examined. No side effects were observed in any patients.
authors.affiliation: Critical Care Medical Center, Kinki University.
authors.forename: I
authors.initials: I
authors.lastname: Sakata
authors.forename: J
authors.initials: J
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Kitagishi
authors.forename: M
authors.initials: M
authors.lastname: Nakaji
authors.forename: H
authors.initials: H
authors.lastname: Yoshinobu
authors.forename: Y
authors.initials: Y
authors.lastname: Mantani
authors.forename: K
authors.initials: K
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Iwaki
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D015377:Cilastatin / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004630:Emergencies; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage; D007223:Infant; D008875:Middle Aged; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D015377:Cilastatin; D015378:Imipenem