[The action of neurotropin on the processes of conditioned-reflex avoidance in rats].
Preliminary neurotropin administration improved subsequent conditioned avoidance learning of rats in a shuttle-box: increased the number of conditioned avoidance reactions and decreased their latency in comparison with the control but did not change the number of intertrial responses. "The demolition" (5 series of negative reinforcements applied despite of avoidance occurrence) caused behavioural stress reactions and inhibited the conditioned and unconditioned avoidance learned reactions. Neurotropin injection before the demolition abolished such disturbances, that having been done after the demolition restored conditioned avoidance. The positive effects of neurotropin were suggested to be due to its antistress property and ability to improve the formation of a result of an acceptor of action.
Kaliuzhnyĭ
L V
LV
Litvinova
S V
SV
Inozemtsev
A N
AN
Kaliuzhnyĭ
A L
AL
Aristova
V V
VV
D000161:Acoustic Stimulation; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012054:Reinforcement, Psychology
D011134:Polysaccharides; C010491:neurotropin
Deĭstvie neĭrotropina na protsessy uslovnoreflektornogo izbeganiia u krys.