title: [Current situation of dominant autosomal renal polycystosis].
abstract: Adult onset polycystic kidney disease causes 11% of all end-stage renal disease in Spain. Recent advantages in the molecular genetics of autosomal dominant polycystic kidney disease (ADPKD) point the way towards the cloning and decoding. One of the gene loci, namely PKD1, was located to the short arm of chromosome 16. Recombinants between 16p polimorphic loci and the PKD1 locus are described. The clinical consecuents of ADPKD are analyzed. Hypertension arterial are found more frequent in the those patients. Caution is therefore recommend in using ACE inhibitors who are at high risk because of compromised renal function. Our study clarifies several clinical extrarenal manifestations of ADPKD. All modalities of renal replacement therapy are appropriate therapeutics choices.
authors.affiliation: Hospital de Galdakao, Osakidetza-Servicio Vasco de Salud, Vizcaya.
authors.forename: R
authors.initials: R
authors.lastname: Ibáñez
authors.forename: J
authors.initials: J
authors.lastname: Ocharán
mesh_terms: D006801:Humans; D016891:Polycystic Kidney, Autosomal Dominant / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy
vernacular_title: Situación actual de la poliquistosis renal autosómica dominante.