title: Facts about once-a-month injectable contraceptives: memorandum from a WHO meeting.
abstract: This Memorandum reviews the results of research undertaken in animals and human subjects on once-a-month injectable contraceptives containing a progestogen and an estrogen, in particular the products Cyclofem and Mesigyna. Results from clinical trials, including effectiveness and side-effects, are evaluated and issues arising from health service research are discussed. The Memorandum concludes with a statement regarding the use of Cyclofem and Mesigyna as options for potential contraceptive users.
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000818:Animals; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000494:pharmacology; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004341:Drug Evaluation; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000008:administration & dosage* / Q000494:pharmacology; D007273:Injections, Intramuscular; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage* / Q000494:pharmacology; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014944:World Health Organization
chemical_list: D003271:Contraceptive Agents, Female; D003277:Contraceptives, Oral, Combined; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004965:Estrogen Antagonists; D004966:Estrogens, Conjugated (USP); D006908:Hydroxyprogesterones; C418365:estradiol, norethindrone drug combination; D000077713:17 alpha-Hydroxyprogesterone Caproate; D004958:Estradiol; C034528:CycloProvera; D017258:Medroxyprogesterone Acetate; D009640:Norethindrone