[Genotoxicity of herbicide 83-1 in yeast assay system].
The genotoxicity of Herbicide 83-1 (Dichloronitrophenolamide, DCNPA) was detected by the yeast D61.M and D7 assay with multi-endpoint. We noted that the frequency of cyhR (resistance to cycloheximide) colonies of D61.M treated with DCNPA on cycloheximide medium was much higher than that of the control (P < 0.01) and that there was a dose-response relationship. These showed that the positivity responsed to the mitotic crossing-over endpoint. To the remaining endpoints in the D61.M and D7 assay, however, the negative response was obtained. The results have demonstrated that Herbicide 83-1 is a DNA damage agent.
Heng
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Wu
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Tang
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D001549:Benzamides / Q000633:toxicity*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004249:DNA Damage / Q000187:drug effects; D004271:DNA, Fungal / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D015003:Yeasts / Q000187:drug effects / Q000235:genetics*
D001549:Benzamides; D004271:DNA, Fungal; D006540:Herbicides; C082456:2,4-dichloro-6-nitrophenolamide