[The vascular protective effect of the combined administration of magnesium chloride and antioxidants in prolonged hypercholesterolemia ].
The angioprotective efficacy of combined application of magnesium chloride and antioxidants during prolonged hypercholesterolemia has been investigated on the experimental model of atherosclerosis in rabbits. The application of magnesium chloride and acetate tocopherol from the very beginning of the atherogenic diet is shown to exert a pronounced angioprotective effect preventing the development of structural and functional changes in the aorta wall. If the treatment is initiated against the background of the well developed atherosclerotic symptoms, its efficacy is less pronounced but remains still on a quite high level. These data indicate that combination of magnesium chloride and antioxidants has not only protective action but can also induce partial regression of the developed atherosclerotic changes.
Talaieva
T V
TV
Taranenko
V M
VM
Isaiechkina
I M
IM
Tyshkin
S M
SM
Sergiienko
O V
OV
Tretiak
I V
IV
Bratus
V V
VV
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D015636:Magnesium Chloride / Q000627:therapeutic use*; D008954:Models, Biological; D011817:Rabbits; D013997:Time Factors; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D015636:Magnesium Chloride; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols
Angioprotektorna efectyvnist poiednanogo vykorystannia khlorystogo magniiu ta antyoksydantiv v umovakh tryvaloĭ giperkholesterynemiĭ.