title: Sulfite suppresses transducer function of the carotid sinus baroreceptor.
abstract: The purpose of this study was to examine the effect of sodium metabisulfite (MBS) solution on the transducer function of the carotid sinus baroreceptor. In anesthetized dogs with vagotomy, we vascularly isolated the carotid bifurcation to load a pressure on the carotid sinus baroreceptor. As the pressure load, we used a slow ramp increase (0.7 mmHg/s) in intracarotid sinus pressure (ICSP). The response of carotid sinus nerve activity (CSNA) to the slow ramp increase in ICSP was suppressed when the isolated carotid sinus was filled with the MBS solution of 10(-2) M. This suppressive effect of MBS solution on the response of CSNA was reversible. The MBS solution had no effect on the pressure-volume relationship of the arterial wall of the isolated carotid sinus and on the impulse conduction of carotid sinus nerve. This suppressive effect of the MBS solution of 10(-2) M was weakened by introducing oxygen gas into the solution to lose the total sulfite anions in the solution. These results suggest that: (1) the MBS solution reversibly suppresses the transducer function of the carotid sinus baroreceptor; (2) the target construction of the carotid sinus region that was affected by the MBS solution might be the carotid sinus baroreceptor nerve terminal where ICSP was transduced into carotid sinus nerve firing; and (3) the suppressive effect might be provoked by the sulfite anions in the MBS solution.
authors.affiliation: Department of Physiology, Kagawa Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fujiki
authors.forename: T
authors.initials: T
authors.lastname: Kawada
authors.forename: N
authors.initials: N
authors.lastname: Uemura
authors.forename: Y
authors.initials: Y
authors.lastname: Nishida
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Hosomi
mesh_terms: D000818:Animals; D002346:Carotid Sinus / Q000187:drug effects*; D004285:Dogs; D005260:Female; D008297:Male; D010084:Oxidation-Reduction; D010100:Oxygen / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*; D013447:Sulfites / Q000494:pharmacology*; D014628:Vagotomy
chemical_list: D013447:Sulfites; C005200:sodium metabisulfite; D010100:Oxygen