title: Synthesis of 3-oxa-5-alkylideneisocarbacyclins.
abstract: 3-Oxa-5-methyleneisocarbacyclin (14a) and 3-oxa-5-ethylideneisocarbacyclin (19a) were synthesized. Compound 14a showed a potent antiplatelet aggregating activity, whereas 19a was inactive.
authors.affiliation: Medicinal Chemistry Research Laboratory, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.forename: S
authors.initials: S
authors.lastname: Amemiya
mesh_terms: D000818:Animals; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D010975:Platelet Aggregation Inhibitors; C041946:9-O-methanoprostaglandin I; D011464:Epoprostenol