Biotransformation of fluorene by the fungus Cunninghamella elegans.
The metabolism of fluorene, a tricyclic aromatic hydrocarbon, by Cunninghamella elegans ATCC 36112 was investigated. Approximately 69% of the [9-14C]fluorene added to cultures was metabolized within 120 h. The major ethyl acetate-soluble metabolites were 9-fluorenone (62%), 9-fluorenol, and 2-hydroxy-9-fluorenone (together, 7.0%). Similarly to bacteria, C. elegans oxidized fluorene at the C-9 position of the five-member ring to form an alcohol and the corresponding ketone. In addition, C. elegans produced the novel metabolite 2-hydroxy-9-fluorenone.
Pothuluri
J V
JV
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
Freeman
J P
JP
Evans
F E
FE
Cerniglia
C E
CE
D001673:Biodegradation, Environmental; D003470:Culture Media / Q000737:chemistry; D005449:Fluorenes / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009090:Mucorales / Q000378:metabolism*; D009172:Mycology / Q000379:methods
D003470:Culture Media; D005449:Fluorenes; C041509:fluorene; C028401:9-fluorenone