title: Non-surgical approaches to stones in the biliary tree.
abstract: Medical treatment of cholesterol gall stones aims to dissolve the stones leaving the biliary tract stone-free and the gall bladder in situ. The introduction of extracorporeal shock wave lithotripsy and contact solvent therapy with methyl tert butyl ether have revolutionised the medical management of both gall bladder stones and bile duct stones which are too large to be treated by sphincterotomy. Both approaches represent a major advance over cheno- and ursodeoxycholic acid which are effective in less than 30% of cases and require prolonged therapy. All medical treatments require a functioning gall bladder and suffer from relapse rates in the order of 10% per annum. Secondary prophylaxis is expensive and the rate of compliance and long term safety have yet to be established.
authors.affiliation: Department of Gastroenterology, Trinity College, Dublin, Ireland.
authors.forename: J J
authors.initials: JJ
authors.lastname: Keating
authors.forename: O I
authors.initials: OI
authors.lastname: Corrigan
authors.forename: A
authors.initials: A
authors.lastname: Chua
authors.forename: G S
authors.initials: GS
authors.lastname: MacDonald
authors.forename: N
authors.initials: N
authors.lastname: Noonan
authors.forename: J
authors.initials: J
authors.lastname: McNulty
authors.forename: P W
authors.initials: PW
authors.lastname: Keeling
mesh_terms: D001647:Bile Acids and Salts / Q000627:therapeutic use; D002769:Cholelithiasis / Q000737:chemistry / Q000628:therapy*; D002784:Cholesterol; D006801:Humans; D008096:Lithotripsy
chemical_list: D001647:Bile Acids and Salts; D002784:Cholesterol