title: Mitral A velocity wave transit time to the outflow tract as a measure of left ventricular diastolic stiffness. Hemodynamic correlations in patients with coronary artery disease.
abstract: BACKGROUND
  Subjects in sinus rhythm have two distinct diastolic flow velocities in the left ventricular (LV) outflow tract directed toward the aortic valve. These follow E and A waves of the transmitral flow and are referred to as Er and Ar waves, respectively. The A wave transit time from the mitral valve to the LV outflow tract is shorter than that of the E wave and is shorter in those with LV hypertrophy and the aged, suggesting its possible dependence on LV late diastolic stiffness. METHODS AND RESULTS. We measured the peak-to-peak and onset-to-onset A wave transit times from the mitral valve to the LV outflow tract (AArp and AAro intervals, respectively) using Doppler echocardiography in 20 patients undergoing left heart catheterization for evaluation of coronary artery disease. These intervals were correlated with indices of LV late diastolic stiffness obtained from high-fidelity LV pressure tracings and angiographic volume assessments. The AArp and AAro intervals correlated significantly with LV Dp/DV (conventionally dP/dV) (r = -.68 and -.83, respectively), volume stiffness, V.Dp/DV (r = -.74 and -.80, respectively) and LV (V/P) (Dp/DV) (r = -.69 and -.74, respectively). The AAro interval correlated better with the square roots of LV Dp/DV and volume stiffness (r = -.86 and -.87, respectively).
  
  
  CONCLUSIONS
  We conclude that AArp and AAro intervals are easily obtainable Doppler parameters that reflect LV late diastolic stiffness in patients with coronary artery disease and possibly in other patients groups.
authors.affiliation: Department of Cardiology, Loma Linda University, Calif.
authors.forename: R G
authors.initials: RG
authors.lastname: Pai
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: J T
authors.initials: JT
authors.lastname: Heywood
authors.forename: D R
authors.initials: DR
authors.lastname: Ferry
authors.forename: P M
authors.initials: PM
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003971:Diastole; D004452:Echocardiography; D004548:Elasticity; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology*; D012044:Regression Analysis; D013997:Time Factors; D016277:Ventricular Function, Left