title: Epithelial-myoepithelial carcinoma of the salivary glands. A study of 22 cases.
abstract: Twenty-two cases of epithelial-myoepithelial carcinoma of major and minor salivary glands were studied retrospectively to define the clinico-pathological profile and to assess the value of DNA ploidy as a prognostic tool. Fifty-nine percent of the cases occurred in the major salivary glands, the patients being mostly females in their 5th to 8th decades. The clinical course was characterized by a high number of recurrences (in 50% of cases). Death due to the neoplastic disease was found in 40% of the patients. The only morphological feature found to be correlated to prognosis was the presence of nuclear atypia in more than 20% of the tumour cells. In 18 cases, cytophotometric DNA analysis was performed; 15 cases had a diploid DNA histogram and 3 an aneuploid one. All the cases that were DNA aneuploid were of the solid, predominantly clear-cell type and were associated with fatal outcome.
authors.affiliation: Serviço de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisboa.
authors.forename: I
authors.initials: I
authors.lastname: Fonseca
authors.forename: J
authors.initials: J
authors.lastname: Soares
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm