Multivariate genetic analysis of apo AI concentration and HDL subfractions: evidence for major locus pleiotropy.
A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins.
Blangero
J
J
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.
Williams-Blangero
S
S
Mahaney
M C
MC
D016632:Apolipoprotein A-I / Q000235:genetics*; D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D016013:Likelihood Functions; D008075:Lipoproteins, HDL / Q000145:classification / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D015999:Multivariate Analysis; D010641:Phenotype
D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL