Complex neuromuscular disorder in a patient with chronic myeloid leukaemia.
We report a 44 year old man who developed external ophthalmoplegia and predominantly respiratory, truncal and bulbar weakness with brisk reflexes, histological evidence of an inflammatory myopathy and a high titre of acetylcholine receptor antibodies, one month after starting hydroxyurea and allopurinol for chronic myeloid leukaemia. The temporal relationship suggests a possible association between this patient's unusual neuromuscular disorder and either the chronic myeloid leukaemia or its treatment.
Bergin
P S
PS
Royal Free Hospital, London, UK.
Gale
A N
AN
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009220:Myositis / Q000209:etiology; D009468:Neuromuscular Diseases / Q000209:etiology*; D009886:Ophthalmoplegia / Q000209:etiology
D000493:Allopurinol; D006918:Hydroxyurea