Evaluation of the significance of the estradiol response during the clomiphene citrate challenge test.
OBJECTIVE
To evaluate the relationship between the E2 response during the clomiphene citrate (CC) challenge test and ovarian responsiveness to exogenous gonadotropins.


METHODS
Performance of a CC challenge test followed by ovulation induction with exogenous gonadotropins as part of participation in an assisted reproduction program.


METHODS
Assisted reproduction program in a large military tertiary care center.


METHODS
Two hundred forty-seven women between the ages of 24 and 39 years with normal CC challenge tests within 1 year of their assisted reproduction cycle.


METHODS
Performance of CC challenge tests and ovulation induction with exogenous gonadotropins as a component of an assisted reproduction cycle.


METHODS
Correlation of the E2 response during the CC challenge test and peak E2, the duration of stimulation, number of ampules of exogenous gonadotropins, number of mature follicles, number of mature oocytes recovered, and fertilization and pregnancy rates in an assisted reproduction program.


RESULTS
No correlation exists between the E2 response during the CC challenge test and any of the parameters evaluated.


CONCLUSIONS
Monitoring of the E2 response during the CC challenge test did not predict ovarian responsiveness or pregnancy rates in patients participating in an assisted reproduction program and one may choose not to include it in routine testing.
Scott
R T
RT
Wilford Hall Medical Center, Lackland Air Force Base, Texas 78236.
Illions
E H
EH
Kost
E R
ER
Dellinger
C
C
Hofmann
G E
GE
Navot
D
D
D000328:Adult; D002996:Clomiphene; D004958:Estradiol / Q000097:blood*; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D012044:Regression Analysis; D017388:Zygote Intrafallopian Transfer
D002996:Clomiphene; D004958:Estradiol