Malignant infiltration of peripheral nerves in the course of acute myelomonoblastic leukaemia: neuropathological study of two cases.
Two patients suffering from acute myelomonoblastic leukaemia developed clinical evidence of peripheral nerve involvement. In both cases, a peripheral nerve biopsy revealed endoneurial cellular infiltrates which were identified as leukaemic cells by immunocytochemistry. Ultrastructural studies showed mainly axonal damage. Moreover, in one patient, a few features of active demyelination were also observed.
Vital
A
A
Department of Neuropathology, Bordeaux Hospital, France.
Vital
C
C
Ellie
E
E
Ferrer
X
X
Lagueny
A
A
Ferrer
A M
AM
Broustet
A
A
Gbikpi-Benissan
G
G
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015477:Leukemia, Myelomonocytic, Chronic / Q000473:pathology*; D017254:Leukemic Infiltration; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016612:Paraffin Embedding; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology