[Vaccinations of children allergic to eggs with vaccine prepared with egg].
BACKGROUND
The mumps, influenza, yellow fever and measles vaccines are grown in chick-embryos. Because allergic reactions to these vaccines have occasionally been reported in children who have suffered anaphylaxis from egg ingestion, it has been claimed that these children should not receive such vaccines.


METHODS
17 egg-allergic children aged 1 year 1 month to 7 years 10 months (mean 2 years 4 months) were studied. All had developed an allergic reaction less than one hour after egg ingestion. Allergy was confirmed by skin testing (prick skin test) and detection of IgE antibodies to egg (RAST).


RESULTS
Seven children were immunized normally by their general practitioner, who was not aware of their allergy; 8 children having negative prick skin and intradermal tests with the vaccine were also immunized normally while 2 children who had positive intradermal test with the vaccine received divided doses following a protocol established for this study. None of these 17 egg-allergic children developed local and/or general reactions. Reintroduction of egg (yolk then white) was tested on the day of immunization in 4 children: only one developed facial edema.


CONCLUSIONS
This protocol permits these vaccines to be safely given to egg-allergic children.
Tounian
P
P
Service d'Allergologie et de Pneumologie Infantiles, Hôpital Necker-Enfants-Malades, Paris.
Delacourt
C
C
de Blic
J
J
Paupe
J
J
Scheinmann
P
P
D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D015387:Egg Proteins, Dietary / Q000009:adverse effects* / Q000276:immunology; D004531:Eggs; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D014611:Vaccination / Q000379:methods*; D014612:Vaccines
D015387:Egg Proteins, Dietary; D014612:Vaccines
Vaccinations des enfants allergiques à l'oeuf par un vaccin préparé sur oeuf.