Gas chromatographic determination of meprobamate in human plasma.
A simplified and rapid gas chromatographic method has been developed for the determination of meprobamate in human plasma. The procedure includes a single-step extraction of alkalinized sample with chloroform, and chromatography on a non-polar fused-silica capillary column with flame ionization detection. The method is accurate (97.7 +/- 5.7% at 20 mg/l) and precise (maximum coefficient of variation of 9.5%). It provides an alternative to existing methods and is particularly suitable for toxicological studies.
Trenque
T
T
Laboratoire de Pharmacologie et de Toxicologie, Centre Hospitalier Régional et Universitaire, Reims, France.
Lamiable
D
D
Millart
H
H
Vistelle
R
R
Choisy
H
H
D000368:Aged; D002725:Chloroform; D002849:Chromatography, Gas; D005260:Female; D006801:Humans; D008620:Meprobamate / Q000097:blood*; D012015:Reference Standards
D002725:Chloroform; D008620:Meprobamate