title: Renal cell carcinoma with osteoclast-like giant cells.
abstract: Primary extraskeletal epithelial neoplasms with osteoclast-like giant cells are rare. We describe a case of renal cell carcinoma with a sarcomatoid component and non-neoplastic osteoclast-like giant cells. The giant cells were noted in both the conventional and the sarcomatoid components of the neoplasm. Immunohistochemical studies indicate that these cells are monocyte/histiocyte in origin and most probably a host stromal reaction to the neoplasm.
authors.affiliation: Department of Pathology, M.D. Anderson Cancer Center, Houston, Texas.
authors.forename: A K
authors.initials: AK
authors.lastname: el-Naggar
authors.forename: K
authors.initials: K
authors.lastname: Gaber
authors.forename: N G
authors.initials: NG
authors.lastname: Ordonez
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology*; D010010:Osteoclasts / Q000473:pathology*
chemical_list: D007381:Intermediate Filament Proteins