title: [Hemodynamic effects and adverse effects of the anti-arrhythmic substance AWD-G256 in man].
abstract: In 19 patients with different supraventricular tachycardias the antiarrhythmic drug AWD-G256 was studied to investigate the effects on hemodynamic parameters. Over all, stroke volume, pulmonary pressure and systemic blood pressure were not significantly altered. The only main adverse effect was a transient rise of serum transaminases in two patients. We conclude that AWD-G256 is usually hemodynamically tolerated, but the antiarrhythmically effective dosage is not reached yet.
authors.affiliation: Abteilung für Kardiologie und Angiologie, Friedrich-Schiller-Universität Jena.
authors.forename: H
authors.initials: H
authors.lastname: Volkmann
authors.forename: G
authors.initials: G
authors.lastname: Dannberg
authors.forename: H
authors.initials: H
authors.lastname: Kühnert
authors.forename: A
authors.initials: A
authors.lastname: Hoffmann
authors.forename: J P
authors.initials: JP
authors.lastname: Marschner
authors.forename: I
authors.initials: I
authors.lastname: Reimann
authors.forename: K
authors.initials: K
authors.lastname: Farker
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001577:Benzophenones / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004594:Electrophysiology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006835:Hydrazones / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects; D013617:Tachycardia, Supraventricular / Q000188:drug therapy / Q000503:physiopathology; D000637:Transaminases / Q000097:blood
chemical_list: D000889:Anti-Arrhythmia Agents; D001577:Benzophenones; D006835:Hydrazones; C080444:(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate; D000637:Transaminases
vernacular_title: Hämodynamische Effekte und Verträglichkeit der antiarrhythmischen Substanz AWD-G256 beim Menschen.