title: Oxidative damage to DNA: levels of thymine glycol and thymidine glycol in neoplastic human urines.
abstract: We have measured the levels of thymine glycol (TG) and thymidine glycol (dTG) in human urine, using an HPLC method. The results show that all 30 specimens examined (including 10 non-neoplastic and 20 neoplastic human urines) contained significant amounts of TG and dTG, average levels (mean +/- SEM) were 0.376 +/- 0.026 and 0.138 +/- 0.009 nmol/kg body weight/day respectively. The average levels of TG and dTG were 0.435 +/- 0.038 and 0.164 +/- 0.017 nmol/kg body weight/day in 10 healthy human urine specimens and 0.347 +/- 0.035 and 0.125 +/- 0.010 nmol/kg body weight/day in 20 neoplastic human urine specimens respectively. No significant differences were found between female and male as well as between the non-neoplastic and neoplastic human urine specimens. There were also wide interindividual variations, which were not age-dependent.
authors.affiliation: Institute of Biophysics, Academia Sinica, Beijing, China.
authors.forename: E H
authors.initials: EH
authors.lastname: Cao
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000652:urine*; D010084:Oxidation-Reduction; D013936:Thymidine / Q000031:analogs & derivatives* / Q000652:urine; D013941:Thymine / Q000031:analogs & derivatives* / Q000652:urine
chemical_list: C029389:thymine glycol; C029390:thymidine glycol; D013941:Thymine; D013936:Thymidine