Involvement of protein kinase C in proliferative response of osteoblastic cell lines stimulated with prostaglandin E2.
The proliferative action of prostaglandin E2 in a rat osteoblastic cell line was studied. Prostaglandin E2 has a crucial effect on bone remodeling process and is shown to stimulate protein and DNA synthesis in serum depleted condition. This reaction is completely inhibited by protein kinase C inhibitors, suggesting that protein kinase C activation induced by prostaglandin E2 is involved in the proliferative response of osteoblast cells.
Miya
T
T
Department of Oral Surgery, School of Medicine, Chiba University, Japan.
Tagawa
M
M
Kato
N
N
Takahashi
K
K
Sato
K
K
Fujimura
S
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D015232:Dinoprostone / Q000494:pharmacology*; D004789:Enzyme Activation; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats
D004247:DNA; D011493:Protein Kinase C; D015232:Dinoprostone