Impaired elimination of atenolol in a nephropathic patient with self-medication overdose.
A case of intoxication with atenolol (plasma concentration of 2.71 mg/L) caused by an improper self-medication combined with impaired renal function is presented. The patient was supported with atropine, isoproterenol, dopamine, and dobutamine, and a thorough pharmacokinetic monitoring of atenolol was conducted. As the serum creatinine concentration returned slowly to baseline with good diuresis, the concentration of atenolol decreased (biologic half-life = 2.95 days) and the blood pressure gradually recovered. The patient improved and was subsequently discharged in good health. Had pharmacokinetic monitoring of atenolol not been performed, hemodialysis would have been indicated.
el-Yazigi
A
A
Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Bouchama
A
A
al-Abdely
H
H
Yusuf
A
A
Sieck
J O
JO
D001262:Atenolol / Q000009:adverse effects / Q000097:blood / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D062787:Drug Overdose; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications / Q000378:metabolism*; D012651:Self Medication
D001262:Atenolol