title: Plasma concentrations of beta-carotene, vitamin A and vitamin E after beta-carotene and vitamin E intake.
abstract: We have studied the metabolism (absorption) of beta-carotene and vitamin E by assigning eleven volunteers to receive daily two capsules of OENOBIOL, each containing 15 mg of beta-carotene and 15 mg of vitamin E, over 60 days. The beta-carotene, vitamin E and vitamin A plasma levels were then determined using new methods developed in our laboratory. After two months, the actively treated group's median beta-carotene and vitamin E levels were significantly higher than those of a control group. However, no significant change between treated and control groups in the mean of vitamin A (retinol) plasma levels were observed. Treatment with beta-carotene, a vitamin A precursor, does not significantly modify the vitamin A levels. This conclusion had already been observed and it is assumed that a plasma level of beta-carotene equal or higher than 0.3 mg/L reflects a nutritional intake of provitamins sufficient to support homeostasis of retinol (Brubacher et al., 1982).
authors.affiliation: INOCOSM, Châtenay-Malabry, France.
authors.forename: E
authors.initials: E
authors.lastname: Postaire
authors.forename: D
authors.initials: D
authors.lastname: Kouyate
authors.forename: G
authors.initials: G
authors.lastname: Rousset
authors.forename: C
authors.initials: C
authors.lastname: Regnault
authors.forename: E
authors.initials: E
authors.lastname: Lati
authors.forename: M
authors.initials: M
authors.lastname: Bejot
authors.forename: P
authors.initials: P
authors.lastname: Gossioux
authors.forename: G
authors.initials: G
authors.lastname: Hazebroucq
mesh_terms: D000042:Absorption; D000328:Adult; D002338:Carotenoids / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood* / Q000493:pharmacokinetics; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids