title: [Ocular complications of intracarotid chemotherapies with nitrosourea agents].
abstract: The authors report ocular complications in intracarotid chemotherapy with Nitrosyl-urea on 39 patients with intracerebral malignant tumor (anaplastic astrocytoma). Internal carotid infusion catheter was in infra-ophthalmic position. They also report 13 ocular complications (33% of cases) as arterial retinal occlusions essentially, ipsilateral to catheter site. Their study and literature revue emphasize five ocular toxicity factors; intracarotid catheter position, type of drug, its quantity, its solubility and solvent, the rate of infusion.
authors.affiliation: Clinique d'Ophtalmologie, Hôpital d'Instruction des Armées du Val de Grâce, Paris.
authors.forename: J C
authors.initials: JC
authors.lastname: Rigal-Sastourne
authors.forename: F
authors.initials: F
authors.lastname: Bidaux
authors.forename: F
authors.initials: F
authors.lastname: Mir
authors.forename: P
authors.initials: P
authors.lastname: Crepy
authors.forename: B
authors.initials: B
authors.lastname: Lucas
authors.forename: J P
authors.initials: JP
authors.lastname: Renard
authors.forename: C
authors.initials: C
authors.lastname: Derosier
authors.forename: J F
authors.initials: JF
authors.lastname: Maurin
authors.forename: H
authors.initials: H
authors.lastname: Bourgeois
mesh_terms: D000328:Adult; D000368:Aged; D002343:Carotid Artery, Internal; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D012164:Retinal Diseases / Q000139:chemically induced
chemical_list: D009607:Nitrosourea Compounds
vernacular_title: Complications oculaires des chimiothérapies intracarotidiennes par nitroso-urées.