Ethanol stimulates apo A-1 secretion in human hepatocytes: a possible mechanism underlying the cardioprotective effect of ethanol.
Ethanol stimulates synthesis of the high-density lipoprotein (HDL) protein apo A-1 in cultured human hepatocytes. This ethanol-induced secretion can increase the efflux of cholesterol from cultured fibroblasts. Enhanced activity of a reverse cholesterol transport pathway mediated by increased hepatic apo A-1 synthesis may explain why epidemiological studies show a relationship between ethanol consumption and lower incidence of coronary heart disease.
D016632:Apolipoprotein A-I / Q000378:metabolism*; D002460:Cell Line; D002784:Cholesterol / Q000378:metabolism; D003327:Coronary Disease / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*
D016632:Apolipoprotein A-I; D000431:Ethanol; D002784:Cholesterol