Mitotic Langerhans cell as a possible sign of activation in ichthyosis.
The fine structure of Langerhans cells (LC) in four rare types of ichthyosis, namely recessive ichthyosis congenita type II, III and IV and ichthyosis hystrix Curth-Macklin was examined. Signs of LC activation were observed in eight of 21 patients. In IC type IV, the rare occurrence of a mitotic LC was observed. It is possible that LCs are secondarily activated in keratinization disorders.
Kanerva
L
L
Section of Dermatology, Institute of Occupational Health, Helsinki, Finland.
Niemi
K M
KM
D006801:Humans; D007057:Ichthyosis / Q000473:pathology*; D007801:Langerhans Cells / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008938:Mitosis