[Antitumor activity of Enterococcus faecalis FK-23 preparation against murine syngeneic tumors].
The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice.
Ohasi
K
K
Central Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Mie, Japan.
Satonaka
K
K
Yamamoto
T
T
Yamazaki
M
M
Kimura
S
S
Abe
S
S
Yamaguchi
H
H
D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D013293:Enterococcus faecalis; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D016685:Mitomycin / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000378:metabolism / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D001688:Biological Products; D014409:Tumor Necrosis Factor-alpha; D016685:Mitomycin; D003520:Cyclophosphamide