title: Application of a mixed imaging sequence for MR imaging characterization of human breast disease.
abstract: Single slice MR images were obtained from 9 normal breasts, 17 breasts with benign tumors, and 11 breasts with malignant tumors using an interleaved (mixed) spin echo (SE) inversion-recovery (IR) imaging sequence. SE and IR MR images were synthesized with variable repetition, echo and inversion times from the mixed sequence data. These images were used to qualitatively evaluate the contrast possibilities available when imaging the breast with MR imaging. Proton T1 and T2 relaxation times were determined for normal breast tissues and malignant and benign breast tumors from pure T1 and T2 images calculated using the mixed sequence data. The mean T1 value in benign tumors of 1,049.02 +/- 40.31 was found to be significantly longer (p < 0.0001) than the mean value of malignant tumors (876.09 +/- 27.83) and normal tissues (795.64 +/- 21.12). The value of T2 in benign tumors (89.15 +/- 8.33) was significantly longer (p < 0.01) than the value of T2 in normal tissues (62.82 +/- 4.06). The mixed sequence can be applied to improve image contrast between malignant tumors, benign tumors, and normal tissues of the breast and can potentially differentiate between these tissues in vivo.
authors.affiliation: Department of Pathology, Academic Hospital University of Utrecht, The Netherlands.
authors.forename: T E
authors.initials: TE
authors.lastname: Merchant
authors.forename: G R
authors.initials: GR
authors.lastname: Thelissen
authors.forename: P W
authors.initials: PW
authors.lastname: de Graaf
authors.forename: C W
authors.initials: CW
authors.lastname: Nieuwenhuizen
authors.forename: H C
authors.initials: HC
authors.lastname: Kievit
authors.forename: W
authors.initials: W
authors.lastname: Den Otter
mesh_terms: D001941:Breast Diseases / Q000175:diagnosis* / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology; D017352:Echo-Planar Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*