Antiepileptic effect of antiepilepsirine in pentylenetetrazol and amygdala kindled rats.
Antiepilepsirine (AES) is a new antiepileptic drug developed in China. Anticonvulsant effects of AES were studied in both pentylenetetrazol (PTZ, n = 20) and amygdala kindled (n = 10) rats. AES was given once per day by oral gavage for 4 weeks. On days 7, 14, 21 and 28, all rats were tested 2 h after daily AES administration: PTZ and amygdala kindled rats were given a PTZ injection (30 mg/kg, i.p.) or amygdala stimulation (400 microA, 1 s), respectively. Behavior was observed, and seizures were graded. AES (300 or 500 mg/kg) produced sustained, dose dependent, protective effects against PTZ induced seizures in PTZ kindled rats, while AES (500 mg/kg) had no effects in amygdala kindled rats.
Wang
L
L
Children's Hospital, Columbus, OH 43205.
Vieth
R
R
Landes
R C
RC
Suzuki
Y
Y
Walson
P D
PD
D000679:Amygdala / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004827:Epilepsy / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000927:Anticonvulsants; D010880:Piperidines; C037547:ilepcimide; D010433:Pentylenetetrazole