title: Improved myocardial protection by antegrade perfusion in combination with coronary sinus occlusion in the presence of left anterior descending artery obstruction.
abstract: The present study was undertaken to evaluate the improved protection of antegrade aortic root perfusion combined with intermittent coronary sinus occlusion (APCSO) for the 1-hour ischemic myocardium in the presence of left anterior descending artery occlusion, 12 dogs were divided into 2 groups: anteperfusion (AP) alone (n = 6) and APCSO (n = 6). The experimental results showed that APCSO provided a better cardioplegic distribution and a lower hypothermia (15.6 degrees C versus 17.2 degrees C) in the occluded LAD region, compared with AP. After ischemia, cardiac index and left ventricular stroke index recovered excellently in APCSO (128% to 141% and 115% to 158% of preischemic values, respectively), and much worse in AP (69% to 82% and 53% to 73% of preischemic values, respectively). Our study has confirmed that APCSO is superior to AP in myocardial protection in the presence of coronary artery occlusion.
authors.affiliation: Department of Cardiovascular Surgery, Tongji Medical University, Wuhan.
authors.forename: X P
authors.initials: XP
authors.lastname: Fu
authors.forename: K J
authors.initials: KJ
authors.lastname: Zhang
authors.forename: S D
authors.initials: SD
authors.lastname: Ye
authors.forename: N G
authors.initials: NG
authors.lastname: Dong
authors.forename: Y M
authors.initials: YM
authors.lastname: Shao
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Xu
authors.forename: H J
authors.initials: HJ
authors.lastname: Lan
mesh_terms: D000818:Animals; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D003331:Coronary Vessels / Q000601:surgery; D004285:Dogs; D006324:Heart Arrest, Induced / Q000379:methods*; D015425:Myocardial Reperfusion / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control
chemical_list: D002314:Cardioplegic Solutions