[Transient aplasia of the red progenitor cells manifest in a child with double heterozygote Hb SC carriership: the role of human parvovirus B19 (HPV-B19)].
Severe pure red cell anaemia due to B19 parvovirus infection is reported in a child with haemoglobin SC disease. B19 parvovirus infection was demonstrated by specific IgM. Although hypoplastic crisis occurring in SC children is usually less frequent and more benign than in sickle- cell anaemia, it necessitated several blood transfusions in our patient. The child recovered rapidly and was discharged after 12 days. This case again illustrates the role of HPV-B19 in the development of transient red cell aplasia occurring in patients with haemolytic anaemia. However, it is unusual since in the few reported children with HbSC disease and HPV-B19 infection, aregenerative anaemia remained moderate and did not generally require blood transfusions.
De Caluwé
J P
JP
Hôpital d'Etterbeek-Ixelles, Bruxelles.
Gilbert
L
L
Alexander
M
M
D000741:Anemia, Aplastic / Q000209:etiology*; D000914:Antibodies, Viral / Q000302:isolation & purification; D002675:Child, Preschool; D016731:Erythema Infectiosum / Q000150:complications* / Q000382:microbiology; D006450:Hemoglobin SC Disease / Q000150:complications*; D006801:Humans; D008297:Male; D016732:Parvovirus B19, Human / Q000276:immunology
D000914:Antibodies, Viral
Aplasie transitoire de la lignée rouge survenant chez un enfant porteur d'une double hétérozygotie HbSC: rôle du parvovirus humain B19 (HPV-B19).