title: [Digoxin-like immunoreactivity in newborn infants--a pitfall of digoxin therapy?].
abstract: Endogenous digoxin-like immunoreactive substances (DLIS) show crossreactions with different immunoassays used for digoxin drug monitoring. In 61 blood samples of 47 eutrophic healthy newborns with jaundice, digoxin serum concentrations were measured during examination of serum bilirubin using a digoxin polarisation immunoassay. Although there was no digoxin therapy in any case, we found positive serum digoxin immunoreactivity (> or = 0.2 ng/ml) in 86% of serum samples. The mean DLIS-concentration was 0.43 +/- 0.19 ng/ml with a maximum of 0.9 ng/ml. We found a significant indirect correlation (rs = -0.34; p = 0.05) between age and serum DLIS concentration. A case report demonstrates the possibility of DLIS interference on digoxin drug monitoring.
authors.affiliation: Klinik für Kinderheilkunde, Medizinischen Akademie Magdeburg.
authors.forename: H R
authors.initials: HR
authors.lastname: Heise
authors.forename: P
authors.initials: P
authors.lastname: Vorwerk
authors.forename: K
authors.initials: K
authors.lastname: Fritsche
authors.forename: R
authors.initials: R
authors.lastname: Richter
mesh_terms: D001798:Blood Proteins / Q000032:analysis*; D002298:Cardenolides; D004077:Digoxin / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D006330:Heart Defects, Congenital / Q000097:blood / Q000188:drug therapy*; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008520:Medigoxin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D012503:Saponins
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D008520:Medigoxin
vernacular_title: Digoxin-ähnliche Immunoreaktivität bei Neugeborenen--eine Falle bei der Digoxintherapie?