Concomitant psoriasis, seborrheic dermatitis, and disseminated cutaneous histoplasmosis in a patient infected with human immunodeficiency virus.
Cutaneous involvement with disseminated histoplasmosis occasionally occurs in patients infected with the human immunodeficiency virus. We describe a profoundly immunocompromised patient with acquired immunodeficiency syndrome who had concomitant psoriasis, seborrheic dermatitis, and disseminated histoplasmosis, each with similar features. Findings of a skin biopsy specimen from a lesion on the forehead showed an infiltrate of histiocytes filled with Histoplasma capsulatum. In disseminated histoplasmosis involving the skin, lesions may have features more characteristic of a papulosquamous dermatosis than an infectious disease. In patients infected with human immunodeficiency virus, especially those with low numbers of CD4+ cells, serious infectious diseases may have unusual features and may assume the appearance of concomitant inflammatory diseases.
Chaker
M B
MB
Department of Pathology (Division of Dermatopathology), University of Texas Southwestern Medical Center, Dallas.
Cockerell
C J
CJ
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D012628:Dermatitis, Seborrheic / Q000150:complications* / Q000175:diagnosis; D003881:Dermatomycoses / Q000150:complications* / Q000175:diagnosis; D006660:Histoplasmosis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000150:complications* / Q000175:diagnosis