[The correction of the liver detoxifying function with phenobarbital and ziksorin before and after ischemia].
Rat experiments have shown preliminary administration of phenobarbital and zixoryn (before ischemia) fails to prevent the hepatic monoxygenase system from ischemic lesion, followed by profound destructive changes in the liver, though the functional activity of the microsomal system remained high. Phenobarbital and zixoryn induction of monooxygenases in the postischemic period contributed to the complete restoration of the levels of microsomal cytochromes and the metabolic activity of xenobiotics in the liver just in its early periods. It is concluded that it is advisable to use the inductors in the postischemic restorative period to correct the detoxifying function of the liver.
Grek
O R
OR
Rybakova
T A
TA
Sharapov
V I
VI
Zakharova
M V
MV
Shkurupiĭ
V A
VA
D000632:Aminopyrine / Q000493:pharmacokinetics; D000814:Aniline Compounds / Q000493:pharmacokinetics; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D008658:Inactivation, Metabolic; D007511:Ischemia / Q000201:enzymology*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009336:Necrosis; D010105:Oxygenases / Q000096:biosynthesis / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000814:Aniline Compounds; D001559:Benzhydryl Compounds; D000632:Aminopyrine; D010105:Oxygenases; C016914:flumecinol; C023650:aniline; D010634:Phenobarbital
Korrektsiia detoksitsiruiushcheĭ funktsii pecheni fenobarbitalom i ziksorinom do i posle ee ishemii.