title: Development of the Baylor-Nikkiso centrifugal pump with a purging system for circulatory support.
abstract: The Baylor-Nikkiso centrifugal pump is a magnetically coupled system with a V-ring seal separating the pump and the actuator chamber. To prevent thrombus formation behind the impeller and to extend the life of the pump to 2 weeks of continuous operation, we incorporated a purging chamber behind the V-ring seal. An external pump connected to this purging chamber infused fluid at a constant rate to wash the shaft-seal area. To evaluate the effectiveness of the purging system, we have carried out biventricular bypass experiments using calves. The purging system was successful in reducing the level of thrombus formation after 2 weeks of operation. The results of these studies confirmed that the Baylor-Nikkiso centrifugal pump with this purging system is suitable for at least 2 weeks of continuous operation as a circulatory support system.
authors.affiliation: Department of Surgery, Baylor College of Medicine, Houston, TX 77030.
authors.forename: K
authors.initials: K
authors.lastname: Naito
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazoe
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: K
authors.initials: K
authors.lastname: Mizuguchi
authors.forename: K
authors.initials: K
authors.lastname: Tasai
authors.forename: Y
authors.initials: Y
authors.lastname: Ohara
authors.forename: Y
authors.initials: Y
authors.lastname: Orime
authors.forename: J
authors.initials: J
authors.lastname: Glueck
authors.forename: S
authors.initials: S
authors.lastname: Takatani
authors.forename: G P
authors.initials: GP
authors.lastname: Noon
mesh_terms: D000818:Animals; D002417:Cattle; D004867:Equipment Design; D006353:Heart-Assist Devices; D006801:Humans; D008955:Models, Cardiovascular; D008961:Models, Structural; D013927:Thrombosis / Q000517:prevention & control*; D013997:Time Factors