title: Testing models for genetic determination in migraine.
abstract: We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.
authors.affiliation: Istituto di Clinica Neurologica, Università di Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mochi
authors.forename: S
authors.initials: S
authors.lastname: Sangiorgi
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: V
authors.initials: V
authors.lastname: Carelli
authors.forename: C
authors.initials: C
authors.lastname: Scapoli
authors.forename: M
authors.initials: M
authors.lastname: Crisci
authors.forename: L
authors.initials: L
authors.lastname: Monari
authors.forename: G
authors.initials: G
authors.lastname: Pierangeli
authors.forename: P
authors.initials: P
authors.lastname: Montagna
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000235:genetics*; D012008:Recurrence; D012678:Sensation Disorders / Q000209:etiology