title: Further analysis of ricin's pyrogenic effect.
abstract: Ricin (RIC) the toxic protein of castor oil seeds (Ricinus communis, Euphorbiaceae;) given intraperitoneally in sublethal doses causes fever in a dose-dependent manner in the following mammals: rabbit, cat, guinea pig, rat and vervet monkey. This hitherto unknown property of ricin calls attention to its use as a pyrogen-substance in the pharmacological screening of new antipyretic drugs.
authors.affiliation: Dept. of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: G A
authors.initials: GA
authors.lastname: Balint
mesh_terms: D000818:Animals; D002415:Cats; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D011749:Pyrogens / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012276:Ricin / Q000633:toxicity*; D013045:Species Specificity
chemical_list: D011749:Pyrogens; D012276:Ricin