[Vibratory perception threshold in normal volunteers].
A feasibility study on the vibratory perception threshold (VPT) in normal volunteers was conducted to detect anti-cancer drug induced peripheral neuropathy. The VPT was found to increase with age. The mean VPT in the main hand in 25 normal volunteers was significantly higher than in the other hand. No variation of VPT was observed in one day or one week. Variation of VPT in the lower extremities was detected between two examiners. In conclusion, the measurement of VPT was expected to be useful for the detection of anti-cancer drug induced peripheral neuropathy, if there is one examiner and the examined hand is specified.
Oshita
F
F
Internal Medicine, National Cancer Center Hospital, Nippon Organon K. K.
Saijo
N
N
Eguchi
K
K
Ohe
Y
Y
Tamura
T
T
Shinkai
T
T
Kodama
N
N
Okada
T
T
Kawahara
M
M
Furuse
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects; D005240:Feasibility Studies; D006801:Humans; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D012684:Sensory Thresholds / Q000502:physiology*; D014732:Vibration
D000970:Antineoplastic Agents