title: [Synthesis of lipoxygenase inhibitors. 1. Synthesis of open-ring amidrazones].
abstract: The synthesis of some amidrazones as bioisosteric diazaallyl radicals is described starting from the reaction mechanism of the lipoxygenases which postulates the existence of a radical after hydrogen abstraction from the arachidonic acid, N1,N3-diaryl-, N1-aryl-N3-alkyl-benzamidrazones and N1-arylacetamidrazones are strong inhibitors of the soja lipoxygenase.
authors.affiliation: Institut für Pharmazeutische Chemie, Fachbereich Pharmazie, Martin-Luther-Universität Halle-Wittenberg.
authors.forename: P
authors.initials: P
authors.lastname: Nuhn
authors.forename: A
authors.initials: A
authors.lastname: Büge
authors.forename: P
authors.initials: P
authors.lastname: Harenberg
authors.forename: H
authors.initials: H
authors.lastname: Lettau
authors.forename: K
authors.initials: K
authors.lastname: Moschner
authors.forename: M
authors.initials: M
authors.lastname: Rauchmaul
authors.forename: R
authors.initials: R
authors.lastname: Schneider
mesh_terms: D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008715:Methionine / Q000378:metabolism; D010084:Oxidation-Reduction; D013025:Glycine max / Q000201:enzymology
chemical_list: D006835:Hydrazones; D016859:Lipoxygenase Inhibitors; D008715:Methionine
vernacular_title: Synthese von Lipoxygenaseinhibitoren. 1. Mitteilung: Synthese von offenkettigen Amidrazonen.