title: Pulmonary thromboembolism and hypertension after thiacetarsamide vs melarsomine dihydrochloride treatment of Dirofilaria immitis infection in dogs.
abstract: The severity of pulmonary thromboembolism and pulmonary hypertension induced by heartworms dying after administration of 2 adulticides was evaluated. Because melarsomine dihydrochloride (RM340) has been shown to be more effective in killing Dirofilaria immitis (heartworms) than the traditional approved adulticide, thiacetarsamide, an attempt was made to determine whether this new adulticide induced more severe lung disease. Before adulticide treatment, 32 dogs with naturally acquired heartworm infections received physical examinations, semiquantitative antigen concentration tests, CBC, platelet counts, serum biochemistry analyses, arterial blood gas determinations, thoracic radiography, pulmonary arteriography, and pulmonary hemodynamic tests. Eight dogs with a low burden and 9 dogs with a high burden of heartworms were treated with thiacetarsamide, and 7 dogs with a low burden and 8 dogs with a high burden were treated with RM340. Except for the heartworm-burden test, tests were repeated at regular intervals during the first 7 weeks after treatment. None of the dogs coughed or had dyspnea after treatment. Six of 9 dogs with high worm burdens and 4 of 8 dogs with low worm burdens had surviving heartworms after thiacetarsamide treatment, in contrast to only 3 of 15 RM340-treated dogs. Differences between the 2 adulticide treatments were minimal as determined by thoracic radiography, pulmonary hemodynamic tests, clinical laboratory analyses, pulmonary arteriography, or necropsy. The RM340 treatment was a more effective adulticide, but it did not increase the severity of hypertension and thromboembolism.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: C A
authors.initials: CA
authors.lastname: Rawlings
authors.forename: J P
authors.initials: JP
authors.lastname: Raynaud
authors.forename: R E
authors.initials: RE
authors.lastname: Lewis
authors.forename: J R
authors.initials: JR
authors.lastname: Duncan
mesh_terms: D000818:Animals; D001148:Arsenamide / Q000009:adverse effects / Q000627:therapeutic use; D001152:Arsenicals / Q000009:adverse effects / Q000627:therapeutic use; D004184:Dirofilariasis / Q000150:complications / Q000188:drug therapy*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005369:Filaricides / Q000009:adverse effects* / Q000627:therapeutic use; D006976:Hypertension, Pulmonary / Q000469:parasitology / Q000662:veterinary*; D011655:Pulmonary Embolism / Q000469:parasitology / Q000662:veterinary*; D014227:Triazines / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D001152:Arsenicals; D005369:Filaricides; D014227:Triazines; C076253:melarsomine; D001148:Arsenamide