Abnormal responses of common variable immunodeficiency patients' B cells to Staphylococcus aureus Cowan I and interleukin-2.
Responses of common variable immunodeficiency patients' B cells to Staphylococcus aureus Cowan I (SAC) and recombinant interleukin-2 (rIL-2) varied in our study. T-cell function and IL-2 production were normal, and intrinsic B-cell defects were suggested. Some patients showed no increase in expression of IL-2 receptors on B cells with SAC stimulation, which may be due to impaired maturation stages. Two patients showed an increased level of B cells with IL-2 receptors, suggesting blocked development of intracellular mechanisms. One patient may have a defect in immunoglobulin isotype switching.
Inoue
Y
Y
Department of Pediatrics, Gifu University School of Medicine, Japan.
Kondo
N
N
Motoyoshi
F
F
Inoue
R
R
Orii
T
T
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000276:immunology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007376:Interleukin-2 / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*
D007376:Interleukin-2; D011947:Receptors, Antigen, B-Cell