title: Effects of the sesquiterpene capsidiol on isolated guinea-pig ileum and trachea, and on prostaglandin synthesis in vitro.
abstract: The sesquiterpene capsidiol, isolated from elicited, cultured cells of Nicotiana silvestris, inhibits contraction induced by the agonists, histamine, acetylcholine, bradykinin, and barium chloride in the isolated guinea-pig ileum. In addition, capsidiol inhibits contraction induced by histamine and carbachol in the isolated guinea-pig trachea in a nonspecific and noncompetitive but concentration-dependent manner. Capsidiol also inhibits prostaglandin synthesis (cyclooxygenase) in vitro in a concentration dependent manner.
authors.affiliation: Department of Pharmacognosy, Biomedical Centre of Uppsala University, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Nasiri
authors.forename: A
authors.initials: A
authors.lastname: Holth
authors.forename: L
authors.initials: L
authors.lastname: Björk
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010947:Plants, Toxic; D011453:Prostaglandins / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes; D014026:Nicotiana / Q000737:chemistry* / Q000166:cytology; D014132:Trachea / Q000187:drug effects; D000094162:Phytoalexins
chemical_list: D010276:Parasympatholytics; D010936:Plant Extracts; D011453:Prostaglandins; D012717:Sesquiterpenes; D013729:Terpenes; C081843:capsidiol; D000094162:Phytoalexins