title: The effect of iron limitation on the growth of Aeromonas salmonicida.
abstract: The effects of the iron-chelating agents ethylenediamine dihydroxyphenylacetic acid (EDDA), 2,2'-dipyridyl (Dipy) and 8-hydroxyquinoline (8HQ) on the growth of Aeromonas salmonicida were examined. In these studies, EDDA caused a small decrease in growth, whereas Dipy and 8HQ reduced cell growth by 50 and 90%, respectively. The extracellular products contained a greater proportion of the major protease (70 kD) when cells were grown in the presence of the chelating agents. Analysis of the outer membrane proteins showed that the chelating agents caused a marked increase in the proportion of proteins in the 70-90 kD range. The effects of Dipy were compared for a number of strains of A. salmonicida.
authors.affiliation: Department of Biological and Molecular Sciences, University of Stirling, Scotland, Great Britain.
authors.forename: B
authors.initials: B
authors.lastname: Neelam
authors.forename: R A
authors.initials: RA
authors.lastname: Robinson
authors.forename: N C
authors.initials: NC
authors.lastname: Price
authors.forename: L
authors.initials: L
authors.lastname: Stevens
mesh_terms: D015082:2,2'-Dipyridyl / Q000494:pharmacology*; D000333:Aeromonas / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D001425:Bacterial Outer Membrane Proteins / Q000187:drug effects*; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010450:Endopeptidases / Q000187:drug effects / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000494:pharmacology; D015125:Oxyquinoline / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D001425:Bacterial Outer Membrane Proteins; D007502:Iron Chelating Agents; D015082:2,2'-Dipyridyl; C026058:EDDA; D015125:Oxyquinoline; D004492:Edetic Acid; D010450:Endopeptidases