[Lipid peroxidation and chromosome aberrations in mice after repeated effect of helium-oxygen respiratory mixture in hyperbaric conditions].
Mice were exposed to helium-oxygen conditions (3.6 MPa, 5 sessions). Compression lasted for 6 h, isopression - 5 days, decompression - 18 h. The interval between sessions was 10 days. The present study has revealed that hyperbary increases the level of diene conjugates and shift bases in the erythrocyte membranes and plasma only after 1 and 3 sessions. Superoxide dismutase is suppressed after 3 and 5 sessions. Catalase activity remains unchanged. The effect of hyperbary on the induction of chromosome aberrations in bone marrow, cornea of the eye and germinal tissues has been studied. Bone marrow has been detected as more sensitive to hyperbary. Induction of aberrations in bone marrow cells has observed for 3 months.
Shkurat
T P
TP
Miliutina
N P
NP
Nechepurenko
A E
AE
Kothcheeva
T A
TA
Sapozhnikov
V M
VM
Novikova
E I
EI
Timofeeva
I V
IV
Shimanskaia
E I
EI
Dashevskiĭ
B S
BS
D000818:Animals; D002869:Chromosome Aberrations; D006371:Helium / Q000494:pharmacology*; D006931:Hyperbaric Oxygenation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D010100:Oxygen / Q000494:pharmacology*
D006371:Helium; D010100:Oxygen
Perekisnoe okislenie lipidov i khromosomnye aberratsii u mysheĭ posle mnogokratnogo vozdeĭstviia geliokislorodnoĭ dykhatelńoĭ smesíu v rezhime giperbarii.