Local effects of cholesterol carrier system on binding of lactogens and epidermal growth factor to the developing mammary gland.
Cholesterol pellets inserted directly into mammary glands of 4- and 10-week-old mice resulted in lactogens, such as human growth hormone and prolactin, and epidermal growth factor. The effects of cholesterol the binding of lactogens and epidermal growth factor to the livers of these same animals was unaffected. Pellets the interscapular region had no effect on binding of either ligand to mammary glands or livers.
Vonderhaar
B K
BK
Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892.
D000818:Animals; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011388:Prolactin / Q000378:metabolism*
D004815:Epidermal Growth Factor; D011388:Prolactin; D013006:Growth Hormone; D002784:Cholesterol