The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
Rectal mucosal proliferation was measured in 116 individuals using the metaphase arrest technique crypt cell production rate (CCPR). CCPR was found to be significantly elevated in individuals with adenomas (n = 42, CCPR = 13 cc c-1h-1, range 7-25 Cl 10-15) compared with normals (n = 21, CCPR = 10 cc c-1h-1 range 5-24 Cl 7-11, Mann-Whitney P = 0.001 z = 3.2). Mucosal proliferation was increased among individuals who were undergoing adenoma follow up but in whom no further adenomas were found (n = 37 CCPR = 12 range 5-26 cc c-1h-1 Cl 10-14) compared to controls (Mann-Whitney P = 0.01 z = 2.4) Proliferation in vegetarians i.e. low risk (n = 16) was similar to controls. Measurement of proliferative indices in rectal mucosa by the stathmokinetic technique CCPR can discriminate between high and low risk groups for colorectal cancer.
Rooney
P S
PS
Department of Surgery, University Hospital, Nottingham, UK.
Clarke
P A
PA
Gifford
K A
KA
Hardcastle
J D
JD
Armitage
N C
NC
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D001706:Biopsy; D002455:Cell Division; D003110:Colonic Neoplasms / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000473:pathology; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology*; D012007:Rectum / Q000166:cytology / Q000473:pathology*; D012307:Risk Factors; D014407:Tumor Cells, Cultured