Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry.
Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.
Mattammal
M B
MB
Geriatric Research, Education and Clinical Center, VA Medical Center, St. Louis, MO 63104.
Chung
H D
HD
Strong
R
R
Hsu
F F
FF
D015102:3,4-Dihydroxyphenylacetic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism*; D013378:Substantia Nigra / Q000737:chemistry*
D015102:3,4-Dihydroxyphenylacetic Acid; C007430:3,4-dihydroxyphenylacetaldehyde; D008995:Monoamine Oxidase; D004298:Dopamine