Proliferation of reticuloendothelial system (RES) in rats with altered vision or smell (to the hypothetic neural regulation of the RES).
A long-term administration of an azo-dye, trypan blue, induced a reactive proliferation of RES in rats. Reaction of the RES was followed in rats whose optical analyzer was eliminated by enucleation of bulbs after the birth, in rats whose smell analyzer was altered by a repeated long-term exposition to ammoniac and in normal rats. Blind rats showed a striking proliferation of histiocytes of the RES in the liver, while the reaction was weak in the spleen and lymph nodes. In contrary to that, rats with altered smell and also the normal rats exhibited standard reactive changes in the spleen and lymph nodes and distinctly weaker reaction in the liver. The obtained results support an idea that vegetative neural mechanisms play a role in control and coordination of RES reactions.
Jansa
P
P
Department of Pathology, Medical Faculty, Palacký University, Olomouc, Czech Republic.
Urbánek
K
K
Riegrová
D
D
D000641:Ammonia / Q000494:pharmacology; D000818:Animals; D001766:Blindness / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000473:pathology*; D000857:Olfaction Disorders / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000473:pathology; D014343:Trypan Blue / Q000494:pharmacology
D000641:Ammonia; D014343:Trypan Blue