Immunohistochemical analysis of 61 pituitary adenomas with a monoclonal antibody to the neuron-specific beta-tubulin isotype.
Pituitary adenomas surgically resected from 61 consecutive patients and 9 normal pituitary glands were studied by immunohistochemistry to determine the localization of the class III beta-tubulin isotype(neuron-specific) which is recognized by the monoclonal antibody TUJ1. In normal pituitary glands only a few cells were weakly immunopositive for TUJ1, whereas, in 43(73%) of 61 adenomas, more than 5% of tumor cells were immunopositive. The result may indicate that this neuron-specific beta-tubulin isotype may be either expressed de novo or enhanced under the transformation of pituitary acinar cells to tumors.
Furuhata
S
S
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Kameya
T
T
Toya
S
S
Frankfurter
A
A
D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D000911:Antibodies, Monoclonal; D006801:Humans; D007536:Isomerism; D009474:Neurons / Q000737:chemistry*; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000473:pathology*; D014404:Tubulin / Q000737:chemistry* / Q000276:immunology
D000911:Antibodies, Monoclonal; D014404:Tubulin