title: Forced expiratory flows and lung volumes in normal infants.
abstract: Forced expiratory flows at functional residual capacity (VmaxFRC) by the rapid compression technique and functional residual capacity (FRC) by the helium dilution technique were assessed in 112 normal infants with a mean age of 10.7 months (range, 1.0-31.0). In predicting FRC, log transformation was appropriate and body length was the best predicator. For VmaxFRC, age was a better predictor than length, and logarithmic transformation was not required. In(FRC) = -5.465 + 2.49 x In(length) SD = 0.178; r2 = 0.83 VmaxFRC = -397 + 9.36 x (age) SD = 88; r2 = 0.52 There were no gender differences for FRC or VmaxFRC; however, male infants exposed to passive cigarette smoke tended to have lower flows than male infants not exposed (P < 0.07). This study establishes normative values for VmaxFRC and FRC in infants between 1 and 31 months of age, and suggests that passive cigarette smoke exposure has an adverse effect upon forced expiratory flows in male infants.
authors.affiliation: Indiana University School of Medicine, Department of Pediatrics, Indianapolis.
authors.forename: R S
authors.initials: RS
authors.lastname: Tepper
authors.forename: T
authors.initials: T
authors.lastname: Reister
mesh_terms: D000367:Age Factors; D001827:Body Height; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D005652:Functional Residual Capacity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000502:physiology*; D008176:Lung Volume Measurements; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D014028:Tobacco Smoke Pollution
chemical_list: D014028:Tobacco Smoke Pollution