Metabotropic glutamate receptors: an original family of G protein-coupled receptors.
In 1985, we discovered a new glutamate receptor which was coupled to phospholipase C via a G protein and which was later termed metabotropic glutamate receptor (mGluR). In this review, both the diversity of mGluRs and the cellular events they control are discussed, as well as their roles in physiological regulation and brain function.
Bockaert
J
J
CNRS UPR 9023, Montpellier, France.
Pin
J
J
Fagni
L
L
D000818:Animals; D001921:Brain / Q000502:physiology / Q000648:ultrastructure; D019204:GTP-Binding Proteins / Q000502:physiology*; D011485:Protein Binding; D017470:Receptors, Glutamate / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism
D017470:Receptors, Glutamate; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins