title: Quantitative assessment of circulatory changes in the fetal aortic isthmus during progressive increase of resistance to umbilical blood flow.
abstract: BACKGROUND
  This study investigated the effects of impairment to placental flow on flow patterns through the aortic isthmus because in the fetus, this vascular segment is the link between the parallel vascular systems perfused by the left and right ventricles.
  
  
  RESULTS
  A progressive increase in resistance to blood flow through the placenta was created in seven exteriorized fetal lambs by mechanical umbilical vein compression. Blood flows were measured in the ascending aorta, pulmonary artery, aortic isthmus, and umbilical artery at baseline and at each compression level. The severity of the levels of compression was determined by changes in the flow profile through the umbilical artery. An increase in placental resistance causing a fall in umbilical blood flow of approximately 50% was associated with a retrograde diastolic flow through the aortic isthmus even though the diastolic flow through the umbilical artery remained forward. Because of the systolic predominance, however, the net flow in the isthmus was forward. With a more severe increase in placental resistance corresponding to a decrease of 75% in umbilical blood flow, the net flow through the isthmus approached zero. A strong positive correlation was found between the umbilical blood flow and the net flow through the aortic isthmus (r = .89).
  
  
  CONCLUSIONS
  Variations in Doppler blood flow velocity waveforms and integrals of the aortic isthmus can be used as a sensitive indicator of the state of the umbilical circulation.
authors.affiliation: Department of Pediatrics, Saint-Justine Hospital, University of Montreal, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Bonnin
authors.forename: J C
authors.initials: JC
authors.lastname: Fouron
authors.forename: G
authors.initials: G
authors.lastname: Teyssier
authors.forename: S E
authors.initials: SE
authors.lastname: Sonesson
authors.forename: A
authors.initials: A
authors.lastname: Skoll
mesh_terms: D000818:Animals; D001011:Aorta / Q000196:embryology*; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging*; D005333:Fetus / Q000098:blood supply*; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D012756:Sheep; D014465:Ultrasonics; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000502:physiology*