title: ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy.
abstract: Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are characteristic features of a particular subset of childhood acute leukemias (AL). In these cases, chromosome aberrations at the 11q23 band are the most frequently reported cytogenetic abnormalities. We have recently cloned a genetic locus named ALL-1, in which DNA breakpoints are clustered in leukemic patients with 11q23 aberrations. Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. These findings indicate that a consistent genetic defect underlies this particular leukemic subset.
authors.affiliation: Department of Hematology, University La Sapienza of Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cimino
authors.forename: F
authors.initials: F
authors.lastname: Lo Coco
authors.forename: A
authors.initials: A
authors.lastname: Biondi
authors.forename: L
authors.initials: L
authors.lastname: Elia
authors.forename: A
authors.initials: A
authors.lastname: Luciano
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
authors.forename: G
authors.initials: G
authors.lastname: Masera
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
authors.forename: E
authors.initials: E
authors.lastname: Canaani
mesh_terms: D000208:Acute Disease; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D004273:DNA, Neoplasm / Q000235:genetics; D015245:Deoxyribonuclease BamHI; D015247:Deoxyribonuclease HindIII; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D015183:Restriction Mapping
chemical_list: D004273:DNA, Neoplasm; D015245:Deoxyribonuclease BamHI; D015247:Deoxyribonuclease HindIII