Pediatric lung transplantation: expanding indications, 1985 to 1993.
The application of lung transplantation to the pediatric population was a natural extension of the success realized in our adult transplant program, which began in 1982. Thirty-two pediatric patients (age range 1 to 18 years) have undergone heart-lung (n = 16), double-lung (n = 14), and single-lung (n = 2) transplantation procedures. The cause of end-stage lung disease was primary pulmonary hypertension (n = 7), congenital heart disease (n = 7), cystic fibrosis (n = 9), pulmonary arteriovenous malformation (n = 2), desquamative interstitial pneumonitis (n = 2), graft-versus-host disease (n = 1), emphysema (n = 1), rheumatoid lung (n = 1), cardiomyopathy (n = 1), and Proteus syndrome (n = 1). Six patients (19%) underwent pretransplantation thoracic surgical procedures. The survival rate was 78% at a mean follow-up of 1.8 years. The survival rate in the 23 recipients without cystic fibrosis was 87% (95% since 1985). The actuarial 1-year survival rate in the nine recipients with cystic fibrosis was 55%. Immunosuppression was cyclosporine (n = 9) or FK 506 (n = 23)-based therapy with azathioprine and steroids. Children were followed up by spirometry, transbronchial biopsy, and primed lymphocyte testing of bronchoalveolar lavage fluid. The mean number of treated episodes of rejection per patient in the groups treated with cyclosporine and FK 506, respectively, was 1.0 and 1.2 at 30 days, 0.67 and 0.38 at 30 to 90 days, and 2.33 and 0.46 at greater than 90 days (p < 0.001, Fisher exact test).(ABSTRACT TRUNCATED AT 250 WORDS)
Armitage
J M
JM
Department of Surgery, University of Pittsburgh School of Medicine, PA.
Fricker
F J
FJ
Kurland
G
G
Michaels
M
M
Griffith
B P
BP
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006084:Graft Rejection; D016041:Heart-Lung Transplantation / Q000706:statistics & numerical data / Q000639:trends; D006801:Humans; D007165:Immunosuppression Therapy; D007223:Infant; D007239:Infections / Q000175:diagnosis / Q000209:etiology; D008171:Lung Diseases / Q000601:surgery; D016040:Lung Transplantation / Q000401:mortality / Q000706:statistics & numerical data / Q000639:trends*; D009926:Organ Preservation; D011183:Postoperative Complications; D015996:Survival Rate