title: Pallidonigroluysian degeneration with iron deposition: a study of three autopsy cases.
abstract: In the basal ganglia of three autopsy cases of pallidonigroluysian degeneration, we found marked iron deposition, a finding which has not been mentioned previously in the literature. Besides severe astrogliosis and neuronal loss in the pallidum, Luysian body and nigra, granular deposits of brown pigments were found in the neuropil, microglias, oligodendrocytes and astrocytes in three such the nuclei and the striatum. These brown pigments proved histochemically to be iron. Our histochemical semiquantitative study showed a significantly stronger reaction for iron in the degenerated nuclei in these three cases than in control cases comprising non-degenerative and the other degenerative diseases. Quantitative study with inductively coupled emission spectrometry also demonstrated a markedly higher iron content in the globus pallidus and the striatum in comparison with the control cases. The possibility is discussed that iron deposition plays a role in generating the lesions of pallidonigroluysian degeneration.
authors.affiliation: Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Sasahara
authors.forename: F
authors.initials: F
authors.lastname: Hazama
authors.forename: S
authors.initials: S
authors.lastname: Kuno
authors.forename: O
authors.initials: O
authors.lastname: Komure
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D000368:Aged; D001253:Astrocytes / Q000473:pathology; D001344:Autopsy; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D003342:Corpus Striatum / Q000473:pathology; D005260:Female; D005917:Globus Pallidus / Q000473:pathology*; D006801:Humans; D007501:Iron / Q000032:analysis* / Q000378:metabolism; D008297:Male; D017628:Microglia / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D009836:Oligodendroglia / Q000473:pathology; D009928:Organ Specificity; D013378:Substantia Nigra / Q000473:pathology*; D013787:Thalamic Nuclei / Q000473:pathology*
chemical_list: D007501:Iron