title: Gas chromatographic determination of meprobamate in human plasma.
abstract: A simplified and rapid gas chromatographic method has been developed for the determination of meprobamate in human plasma. The procedure includes a single-step extraction of alkalinized sample with chloroform, and chromatography on a non-polar fused-silica capillary column with flame ionization detection. The method is accurate (97.7 +/- 5.7% at 20 mg/l) and precise (maximum coefficient of variation of 9.5%). It provides an alternative to existing methods and is particularly suitable for toxicological studies.
authors.affiliation: Laboratoire de Pharmacologie et de Toxicologie, Centre Hospitalier Régional et Universitaire, Reims, France.
authors.forename: T
authors.initials: T
authors.lastname: Trenque
authors.forename: D
authors.initials: D
authors.lastname: Lamiable
authors.forename: H
authors.initials: H
authors.lastname: Millart
authors.forename: R
authors.initials: R
authors.lastname: Vistelle
authors.forename: H
authors.initials: H
authors.lastname: Choisy
mesh_terms: D000368:Aged; D002725:Chloroform; D002849:Chromatography, Gas; D005260:Female; D006801:Humans; D008620:Meprobamate / Q000097:blood*; D012015:Reference Standards
chemical_list: D002725:Chloroform; D008620:Meprobamate