title: Biotransformation of fluorene by the fungus Cunninghamella elegans.
abstract: The metabolism of fluorene, a tricyclic aromatic hydrocarbon, by Cunninghamella elegans ATCC 36112 was investigated. Approximately 69% of the [9-14C]fluorene added to cultures was metabolized within 120 h. The major ethyl acetate-soluble metabolites were 9-fluorenone (62%), 9-fluorenol, and 2-hydroxy-9-fluorenone (together, 7.0%). Similarly to bacteria, C. elegans oxidized fluorene at the C-9 position of the five-member ring to form an alcohol and the corresponding ketone. In addition, C. elegans produced the novel metabolite 2-hydroxy-9-fluorenone.
authors.affiliation: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
authors.forename: J V
authors.initials: JV
authors.lastname: Pothuluri
authors.forename: J P
authors.initials: JP
authors.lastname: Freeman
authors.forename: F E
authors.initials: FE
authors.lastname: Evans
authors.forename: C E
authors.initials: CE
authors.lastname: Cerniglia
mesh_terms: D001673:Biodegradation, Environmental; D003470:Culture Media / Q000737:chemistry; D005449:Fluorenes / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009090:Mucorales / Q000378:metabolism*; D009172:Mycology / Q000379:methods
chemical_list: D003470:Culture Media; D005449:Fluorenes; C041509:fluorene; C028401:9-fluorenone