title: Mandible enclosure of upper airway and weight in obstructive sleep apnea.
abstract: Although anatomic lesions and obesity can produce obstructive sleep apnea (OSA), most subjects with OSA have no recognizable anatomic lesion. We hypothesized that the occurrence of OSA is related to the size of the region enclosed by the mandible and the degree of obesity. We studied 30 subjects with a range of OSA and obesity with magnetic resonance imaging (MRI). MRI was performed with T-1 weighted sequences. Nocturnal polysomnography was performed in all subjects. Univariate regression analysis indicated there was a significant correlation between the number of apneas and hypopneas per hour of sleep (AH/h) and (1) the area enclosed by the mandible ramus (AMR1) (r = 0.48, p < 0.01) and (2) the distance from the teeth to the posterior mandible ramus (r = 0.39, p < 0.05). Stepwise multiple regression analysis indicated that weight, AMR1, and height explained 69% of the variance of AH/h (r2 = 0.69). We conclude that the occurrence of OSA in these subjects is related to the size of the region enclosed by the mandible as well as to their weight.
authors.affiliation: Department of Internal Medicine, University of Virginia Health Science Center, Charlottesville 22908.
authors.forename: K E
authors.initials: KE
authors.lastname: Shelton
authors.forename: S B
authors.initials: SB
authors.lastname: Gay
authors.forename: D E
authors.initials: DE
authors.lastname: Hollowell
authors.forename: H
authors.initials: H
authors.lastname: Woodson
authors.forename: P M
authors.initials: PM
authors.lastname: Suratt
mesh_terms: D000328:Adult; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008334:Mandible / Q000503:physiopathology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D017286:Polysomnography / Q000706:statistics & numerical data; D012044:Regression Analysis; D012137:Respiratory System / Q000503:physiopathology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*