Direct high-performance liquid chromatography (HPLC) separation of etodolac enantiomers using chiral stationary phases.
The enantiomers of the antiinflammatory drug Etodolac were separated without derivatization on Chiralcel OD and Pirkle (R)-DNBPG columns. Enantiomeric purity can be determined in less than 10 min. Optimization of separation was evaluated using various concentrations of 2-propanol (doped with TFA) in hexane as the mobile phase.
Caccamese
S
S
Department of Chemical Sciences, University of Catania, Italy.
D002851:Chromatography, High Pressure Liquid; D017308:Etodolac / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013607:Tablets
D013607:Tablets; D017308:Etodolac