title: Long-term fluoride release of visible light-activated composites in vitro: a correlation with in situ demineralisation data.
abstract: Fluoridated composites are able to reduce or inhibit secondary caries around fillings. The aims of this study were firstly to investigate the amount of F released in vitro from composites with a F content between 0 and 26 vol% as a function of time over a 1-year period. A second aim was to correlate the in vitro data on F release with enamel demineralisation data in situ after a 1-month period. The results show that all fluoridated composites release sizable amounts of F in solution, the total amounts of F released from three composites were proportional to log t over at least 1 year. In one case proportionality of the total amount of F released with t was observed. Possible mechanisms of F release are considered. The results presented also show a linear relation between the log of in vitro F release data and the effects on enamel demineralisation in situ next to the composite. Extrapolation of the data reveals that a F release of about 200-300 micrograms/cm2 over a 1-month period from a fluoridated composite would completely inhibit secondary caries under plaque conditions.
authors.affiliation: Materia Technica, University of Groningen, The Netherlands.
authors.forename: G E
authors.initials: GE
authors.lastname: Dijkman
authors.forename: J
authors.initials: J
authors.lastname: de Vries
authors.forename: A
authors.initials: A
authors.lastname: Lodding
authors.forename: J
authors.initials: J
authors.lastname: Arends
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D003188:Composite Resins / Q000032:analysis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D003743:Dental Enamel / Q000473:pathology*; D003793:Dental Restoration, Permanent; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D006801:Humans; D011140:Polyurethanes / Q000737:chemistry; D019279:Resin Cements; D013997:Time Factors; D017001:Tooth Demineralization / Q000473:pathology* / Q000517:prevention & control
chemical_list: D000180:Acrylic Resins; C029012:Composite Dental Resin; D003188:Composite Resins; D003692:Delayed-Action Preparations; D011140:Polyurethanes; D019279:Resin Cements; C072653:Helio Progress; C047484:heliosit; D005459:Fluorides