The use of imipenem-cilastatin in neonatal meningitis caused by Citrobacter diversus.
Citrobacter diversus is a cause of severe meningitis in neonates and infants. It is unique in its propensity to produce brain abscesses that play an important role in the poor prognosis associated with this condition. The recommended therapeutic regimen of third-generation cephalosporines, aminoglycosides and trimethoprim-sulfamethoxazole is usually disappointing. We describe the use of imipenemcilastatin in successfully treating Citrobacter diversus meningitis complicated by brain abscesses.
Haimi-Cohen
Y
Y
Department of Pediatrics, Golda Medical Center, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tiqva, Israel.
Amir
J
J
Weinstock
A
A
Varsano
I
I
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D015377:Cilastatin / Q000627:therapeutic use*; D000077728:Cilastatin, Imipenem Drug Combination; D002954:Citrobacter; D004338:Drug Combinations; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination