[Prevention of thrombosis in protein C deficiency].
In a 14-years old girl, suffering from deep venous thrombosis protein C deficiency (activity: 55-58%) was diagnosed. Following rethrombosis oral anticoagulant therapy (OAT) with Phenprocoumon (Marcumar) was started. To find the required dosage for OAT the concentrations of prothrombin fragment (F1+2; < 0.5 nM/l) and fibrin monomers (< 2.5 mg/l) were measured. With this procedure an unusually high thromboplastin time (40-45%) was found to be safe.
Geiss-Holtorff
R
R
Kinderklinik, Johannes-Gutenberg-Universität, Mainz.
Hafner
G
G
Prellwitz
W
W
D000293:Adolescent; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D010644:Phenprocoumon / Q000008:administration & dosage*; D010690:Phlebography; D020151:Protein C Deficiency; D011516:Prothrombin / Q000032:analysis; D011517:Prothrombin Time; D012008:Recurrence; D013924:Thrombophlebitis / Q000097:blood / Q000517:prevention & control*
D011516:Prothrombin; D005340:Fibrinogen; D006493:Heparin; D010644:Phenprocoumon
Zur Thromboseprophylaxe bei Protein-C-Mangel.