title: Efficacy and toxicity of fractionated stereotactic radiotherapy in the treatment of recurrent gliomas (phase I/II study).
abstract: Twenty-two patients with recurrent glioma have been treated on a dose escalation protocol with fractionated stereotactic external beam radiotherapy (SRT). All had previously received radical radiotherapy (median dose 55 Gy) as part of the initial treatment. The dose of SRT was increased from 30 Gy in six fractions to 50 Gy in ten fractions. Median survival from the date of SRT was 9.8 months. There was no significant acute morbidity but five patients who received > or = 40 Gy developed steroid responsive neurological deterioration assumed to represent late radiation damage. The survival and toxicity in patients with recurrent glioma are comparable with interstitial therapy. Fractionated SRT is a noninvasive form of localised radiation which may be a suitable alternative to interstitial therapy in this group of patients.
authors.affiliation: Neuro-oncology Unit, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Laing
authors.forename: A P
authors.initials: AP
authors.lastname: Warrington
authors.forename: J
authors.initials: J
authors.lastname: Graham
authors.forename: J
authors.initials: J
authors.lastname: Britton
authors.forename: F
authors.initials: F
authors.lastname: Hines
authors.forename: M
authors.initials: M
authors.lastname: Brada
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001254:Astrocytoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D001927:Brain Diseases / Q000209:etiology / Q000517:prevention & control; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000627:therapeutic use; D005500:Follow-Up Studies; D005910:Glioma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D015996:Survival Rate
chemical_list: D003907:Dexamethasone