MR imaging of blood oxygenation-dependent changes in focal renal ischemia and transplanted liver tumor in rat.
The potential of using fast magnetic resonance (MR) imaging in conjunction with apnea-induced blood deoxygenation for the noninvasive monitoring of relative perfusion in the rat abdomen has been studied with two experimental models: glycerol-induced focal renal ischemia and transplanted liver tumor. Gradient-echo echo-planar imaging (GRE-EPI) (TE of 20 msec at 2T) of liver and kidney was performed before, during, and after a 60-second apnea episode and then was followed in the same rat by contrast-enhanced (a) GRE-EPI and (b) T1-weighted spin-echo imaging (TR msec/TE msec = 200/6) with polylysine-(gadolinium-DTPA [diethylenetriaminepentaacetic acid]). The results indicate that a noninvasive vascular challenge due to apnea can be used for the detection of focal tissue perfusion abnormalities in rat kidney and liver tumor.
Vexler
V S
VS
Department of Radiology, University of California, San Francisco 94143-0628.
de Crespigny
A J
AJ
Wendland
M F
MF
Kuwatsuru
R
R
Mühler
A
A
Brasch
R C
RC
Moseley
M E
ME
D000818:Animals; D017352:Echo-Planar Imaging; D007511:Ischemia / Q000097:blood / Q000175:diagnosis*; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000175:diagnosis*; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010100:Oxygen