Effects of unilateral or bilateral release of bilateral ureteral obstruction on renal function in rat.
Renal function was examined after unilateral release, bilateral release or unilateral release and contralateral nephrectomy in three groups of rats following 24 h of bilateral ureteral obstruction (BUO). Excretion of water, sodium and urea was significantly greater in rats with unilateral release of BUO than in a single kidney of rats with bilateral release of BUO, in spite of similar levels of glomerular filtration rate (GFR) and effective renal plasma flow. Rats with unilateral release of obstruction and contralateral nephrectomy had a significantly lower GFR than the other two groups. These rats also responded with greater increases in fractional sodium and water excretion to the administration of exogenous atrial peptide. The results demonstrate a marked compensatory increase in sodium and water excretion in rats with unilateral release of the obstruction which serves to maintain homeostasis of fluid and salt. They also suggest a possible influence of the continuously obstructed kidney on the function of the postreleased kidney. The results also provide experimental support for a greater recovery of renal excretory function after bilateral release of obstruction.
Modi
K S
KS
Department of Medicine, Washington University School of Medicine, St. Louis, Mo.
Harris
K P
KP
Klahr
S
S
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D009318:Natriuresis / Q000187:drug effects; D009392:Nephrectomy; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000187:drug effects; D014517:Ureteral Obstruction / Q000503:physiopathology*
D010446:Peptide Fragments; C062525:atrial natriuretic factor prohormone (103-126); D009320:Atrial Natriuretic Factor