title: Acute systemic hypoxia and the surface ultrastructure and morphological characteristics of rat leucocytes.
abstract: We have examined the surface ultrastructure and morphological characteristics of leucocytes obtained from control rats breathing air and rats made acutely hypoxic (breathing 6% O2, for 30 min). Striking ultrastructural and morphological changes occurred in the leucocytes of hypoxic rats. These changes included the appearance of crater-like holes, a reduction in granule size and disruption of the cell membrane. The implications of these findings are discussed.
authors.affiliation: Department of Physiology, Medical School, University of Birmingham.
authors.forename: R
authors.initials: R
authors.lastname: Mian
authors.forename: D
authors.initials: D
authors.lastname: Westwood
authors.forename: P
authors.initials: P
authors.lastname: Stanley
authors.forename: J M
authors.initials: JM
authors.lastname: Marshall
authors.forename: J H
authors.initials: JH
authors.lastname: Coote
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D048429:Cell Size; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D000860:Hypoxia / Q000097:blood*; D007962:Leukocytes / Q000648:ultrastructure*; D051381:Rats