title: AIDA2: a Mk. II automated insulin dosage advisor.
abstract: A prototype computer system has been developed to provide advice on the day-to-day adjustment of insulin dosage in the insulin-dependent (type 1) diabetic patient. The system also allows the patient's daily steady-state blood glucose profile to be generated based on these adjustments using a clinical model of glucose-insulin interaction. The prototype is intended to be used as a decision support system by clinical personnel. It is designed for use during consultations, as a simulator of patient response following changes in the insulin and/or dietary regimen, and as a system to provide education on planning insulin therapy. Advice is generated by a qualitative therapeutic advisor which suggests what the next step in improving glycaemic control might be for a given patient. The clinical model attempts to reflect the underlying (patho)physiology of insulin action and carbohydrate absorption in quantitative terms. It consists of a one-compartment glucose model linked to a model with plasma and 'active' insulin compartments. An overview of the integrated prototype is provided along with a detailed description of the new time-point-orientated logical reasoning methodology adopted by the therapeutic advisor. The operation of the system is illustrated by a clinical case study from a 70 kg, male, insulin-dependent diabetic patient.
authors.affiliation: Diabetes Research Laboratory, United Medical School, Guy's Hospital, University of London, England.
authors.forename: E D
authors.initials: ED
authors.lastname: Lehmann
authors.forename: T
authors.initials: T
authors.lastname: Deutsch
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003661:Decision Support Techniques; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004032:Diet; D004360:Drug Therapy, Computer-Assisted / Q000295:instrumentation*; D005069:Evaluation Studies as Topic; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008954:Models, Biological
chemical_list: D001786:Blood Glucose; D007328:Insulin