Laryngeal involvement in neurofibromatosis.
Neurofibromas of the larynx are an uncommon component of neurofibromatosis, but should be considered in the differential diagnosis of patients with a submucosal supraglottic mass. Complete surgical excision is the treatment of choice; however, incomplete excision may be preferable to aggressive debilitating surgery. Plexiform neurofibroma differs from non-plexiform neurofibroma in that it is poorly circumscribed and highly infiltrative. Tracheostomy may be necessary. Sarcomatous degeneration is reported and carries a poor prognosis.
Willcox
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Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia.
Rosenberg
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Handler
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D000328:Adult; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D018318:Neurofibroma, Plexiform / Q000473:pathology*; D009456:Neurofibromatosis 1 / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology