Histamine content of the oxyntic mucosa from duodenal ulcer patients: effect of Helicobacter pylori eradication.
The histamine concentration of the oxyntic mucosa was determined in Helicobacter pylori-positive patients with duodenal ulcer before and after antimicrobial therapy and in H. pylori-negative subjects. Determination of serum gastrin was also performed in duodenal ulcer patients before and after H. pylori eradication. The histamine content of the oxyntic mucosa was lower in patients with duodenal ulcer than in H. pylori-negative subjects, but it increased after H. pylori eradication. Conversely, in patients in whom therapy failed to eradicate the microorganism, the histamine content remained unchanged. Serum gastrin levels fell after microorganism eradication, and the percentage of this fall was correlated with the percentage of increase in gastric histamine. In conclusion, our findings suggest that abnormalities of histamine store present in duodenal ulcer patients might be a feature of H. pylori infection.
Queiroz
D M
DM
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil.
Mendes
E N
EN
Rocha
G A
GA
Moura
S B
SB
Resende
L M
LM
Cunha-Melo
J R
JR
Coelho
L G
LG
Passos
M C
MC
Oliveira
C A
CA
Lima Júnior
G F
GF
D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000378:metabolism / Q000382:microbiology*; D005260:Female; D005664:Furazolidone / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000737:chemistry*; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000378:metabolism; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006632:Histamine / Q000032:analysis*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D013997:Time Factors
D005755:Gastrins; D008795:Metronidazole; D005664:Furazolidone; D000658:Amoxicillin; D006632:Histamine