title: Analysis of the short-term effect of two viscoelastic agents on the intraocular pressure after extracapsular cataract extraction. Sodium hyaluronate 1% vs hydroxypropyl methylcellulose 2%.
abstract: We conducted a study to evaluate the shortterm effect on intraocular pressure (IOP) following extracapsular cataract extraction using either sodium hyaluronate 1% or hydroxypropyl methylcellulose 2%. In both groups a non-significant rise in IOP at day 1 was followed by a significant decline in IOP at day 3 to values below the pre-operative level (p < 0.05). At day 7 both groups had returned to pre-operative values. Post-operatively, spikes in intraocular pressure (> 25 mmHg) were seen equally in both groups. Patients with pre-operatively diagnosed open-angle glaucoma, high myopia and diabetic retinopathy are considered to be at high risk concerning post-operatively elevated IOP, but with small variation these patients followed the main trend.
authors.affiliation: Department of Ophthalmology, Gentofte Hospital, University of Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Storr-Paulsen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D003930:Diabetic Retinopathy / Q000150:complications; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D065347:Hypromellose Derivatives; D007429:Intraocular Pressure / Q000187:drug effects*; D007910:Lenses, Intraocular; D008297:Male; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D009216:Myopia / Q000150:complications; D009798:Ocular Hypertension / Q000503:physiopathology / Q000517:prevention & control*; D009883:Ophthalmic Solutions; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D009883:Ophthalmic Solutions; D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D008747:Methylcellulose