The effect of adrenalectomy on the circadian variation in the rate of kindled seizure development.
The hypothalamic-pituitary adrenal axis (HPAA) is activated during kindled seizures and the circadian changes in this axis may contribute to the circadian variation in the kindling rate. Changes in the rate of seizure development were examined in rats that were amygdala kindled in the a.m., at midday and in the p.m.. Sham operated control groups were compared to adrenalectomized groups. Adrenalectomy had no effect on the midday rate but abolished the normal circadian variation by accelerating the rate in the a.m. and decreasing the rate in the p.m.. These results suggest a complicated relationship of kindled seizure rate to the hormones of the HPAA axis.
Weiss
G
G
University of New Mexico, School of Medicine, Department of Physiology, Albuquerque 87131.
Lucero
K
K
Fernandez
M
M
Karnaze
D
D
Castillo
N
N
D000315:Adrenalectomy; D000679:Amygdala / Q000502:physiology; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004567:Electrodes, Implanted; D005938:Glucocorticoids / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000503:physiopathology*
D005938:Glucocorticoids