Unp, a mouse gene related to the tre oncogene.
We have cloned cDNAs from a novel gene designated Unp. Unp cDNAs contain a large open reading frame that would encode a protein of 89 kDa. The predicted protein contains a putative nuclear localization signal, as well as consensus sequences for binding to the retinoblastoma gene product. The latter elements are contained within a region having strong similarity to the human tre oncogene. We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies.
Gupta
K
K
Department of Biochemistry, University of Ottawa, Canada.
Copeland
N G
NG
Gilbert
D J
DJ
Jenkins
N A
NA
Gray
D A
DA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D010450:Endopeptidases; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D015513:Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000737:chemistry / Q000235:genetics; D009857:Oncogenes; D011518:Proto-Oncogene Proteins; D016415:Sequence Alignment; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases
D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; C082325:Usp4 protein, mouse; D010450:Endopeptidases; C473330:USP6 protein, human; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases