title: Cost-benefit analysis for the use of Haemophilus influenzae type b conjugate vaccine in Santiago, Chile.
abstract: Cost-benefit analyses can be integral to the evaluation of interventions in developing countries. The authors compare the potential benefits to the Chilean Ministry of Health, in terms of treatment costs averted, by prevention of Haemophilus influenzae type b (HIB) invasive disease, with the costs of adding HIB conjugate vaccine to the diphtheria-tetanus-pertussis (DTP) immunization routinely administered to infants. In their basecase model, over a 10-year period (1991-2000), vaccination against HIB will prevent 1,229 cases of HIB invasive disease, including 713 cases of meningitis, 107 of whom would suffer severe, long-term sequelae, and between 29 and 116 deaths. Assuming a cost of US$1 for a full three-dose regimen of vaccine, the benefit/cost ratio of 1.66, with a net discounted savings of over $403,225, illustrates that HIB vaccine can be cost-beneficial. Sensitivity analyses which alter each of the variables in the analysis indicate that if the true incidence of HIB disease is twice the published rate, then three doses of vaccine remains cost-beneficial at US#3.
authors.affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201.
authors.forename: O S
authors.initials: OS
authors.lastname: Levine
authors.forename: E
authors.initials: E
authors.lastname: Ortiz
authors.forename: R
authors.initials: R
authors.lastname: Contreras
authors.forename: R
authors.initials: R
authors.lastname: Lagos
authors.forename: P
authors.initials: P
authors.lastname: Vial
authors.forename: A
authors.initials: A
authors.lastname: Misraji
authors.forename: C
authors.initials: C
authors.lastname: Ferreccio
authors.forename: C
authors.initials: C
authors.lastname: Espinoza
authors.forename: L
authors.initials: L
authors.lastname: Adlerstein
authors.forename: P
authors.initials: P
authors.lastname: Herrera
mesh_terms: D001428:Bacterial Vaccines / Q000191:economics*; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D003362:Cost-Benefit Analysis; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000191:economics*; D006192:Haemophilus Infections / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D008583:Meningitis, Haemophilus / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control; D012680:Sensitivity and Specificity
chemical_list: D001428:Bacterial Vaccines; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C080881:diphtheria-tetanus-pertussis-haemophilus b conjugate vaccine