title: Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study.
abstract: Many structural brain abnormalities have been described in schizophrenia, consistent with a neurodevelopmental model for this disease. We report here a study of the cavum septum pellucidum (CSP) in schizophrenia compared to control groups, as well as the clinical correlates of this congenital anomaly in schizophrenia. We conducted a magnetic resonance imaging (MRI) study to compare rates of CSP in schizophrenia (N = 67) v. psychiatric controls (bipolar and schizoaffective, N = 60) and healthy controls (N = 37). Of the controls 18.9%, and of all psychotic subjects 18.1% had a CSP of any size and there was no difference in the frequency of large CSP among the groups. Males had higher rates of CSP than females (25% v. 9.7%, P = 0.01) in all groups. Schizophrenics had higher CSP rates than affective patients (25%, v. 10%, P = 0.02). No clinical difference was found between schizophrenics with or without CSP.
authors.affiliation: Department of Psychiatry, Ohio State University, College of Medicine, Columbus 43210.
authors.forename: G J
authors.initials: GJ
authors.lastname: Jurjus
authors.forename: H A
authors.initials: HA
authors.lastname: Nasrallah
authors.forename: S C
authors.initials: SC
authors.lastname: Olson
authors.forename: S B
authors.initials: SB
authors.lastname: Schwarzkopf
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology; D012565:Schizophrenic Psychology; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000473:pathology