Mid-latency auditory evoked potentials in humans during anesthesia with S (+) ketamine--a double-blind, randomized comparison with racemic ketamine.
Mid-latency auditory evoked potentials (MLAEP) reflect the primary cortical processing of auditory stimuli. They are suppressed widely during general anesthesia. Under ketamine, in contrast, MLAEP seem to be preserved. Ketamine exists in two optical isomers, S (+) ketamine and R (-) ketamine, which differ in their pharmacodynamic properties. S (+) ketamine has a higher anesthetic-hypnotic and analgesic potency than R (-) ketamine or the racemic mixture of S (+) ketamine and R (-) ketamine. In a blinded, randomized evaluation we compared the effect of induction of general anesthesia with the more potent ketamine compound--S (+) ketamine--to induction with the racemic ketamine on MLAEP in 60 patients scheduled for minor gynecologic procedures. Anesthesia was induced with S (+) ketamine (1 mg/kg Group I, n = 30) or an equi-anesthetic dose of racemic ketamine (2 mg/kg, Group II, n = 30). Auditory evoked potentials (AEP) were recorded before, during, and after induction of general anesthesia. Latencies of the peaks V, Na, Pa, Nb, and P1 and amplitudes Na/Pa, Pa/Nb, and Nb/P1 were measured. A fast-Fourier transform was used to calculate the power spectra of the AEP. The baseline MLAEP peaks of the awake patients were of normal amplitude and demonstrated a characteristic periodic wave form morphology. Power spectra indicated high energy in the 30-40 Hz frequency range. After induction of general anesthesia with S (+) ketamine or racemic ketamine, there was no increase in latencies of peaks V, Na, Pa, Nb, or P1. No decrease in amplitudes Na/Pa, Pa/Nb, or Nb/P1 could be observed. There was no significant change in the power spectra.(ABSTRACT TRUNCATED AT 250 WORDS)
Schwender
D
D
Institute for Anesthesiology, University of Munich, Germany.
Faber-Züllig
E
E
Fett
W
W
Klasing
S
S
Finsterer
U
U
Pöppel
E
E
Peter
K
K
D000328:Adult; D000768:Anesthesia, General; D004311:Double-Blind Method; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007649:Ketamine; D008297:Male; D008875:Middle Aged; D013237:Stereoisomerism; D013997:Time Factors
D007649:Ketamine