title: The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.
abstract: The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with I kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of I kappa B-alpha, the bcl-3 gene product superactivates NF-kappa B p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappa B motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.
authors.affiliation: Rockefeller University, New York, New York 10021.
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: G P
authors.initials: GP
authors.lastname: Nolan
authors.forename: H C
authors.initials: HC
authors.lastname: Liou
authors.forename: M L
authors.initials: ML
authors.lastname: Scott
authors.forename: D
authors.initials: D
authors.lastname: Baltimore
mesh_terms: D000818:Animals; D000081242:B-Cell Lymphoma 3 Protein; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008156:Luciferases / Q000235:genetics; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; C000631345:Bcl3 protein, mouse; C000715470:MAS1 protein, human; D016328:NF-kappa B; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA; D008156:Luciferases