title: Hematometra associated with estrogen replacement therapy.
abstract: We have described two cases of hematometra occurring after initiation of estrogen replacement therapy. In both cases, cervical stenosis had developed during a prolonged period of hypoestrogenism. After initiation of sequential estrogen/progestin therapy, the stenosis prevented menstrual flow, and sonography revealed an asymptomatic hematometra in both cases. Based on these cases, we recommend doing a baseline evaluation of cervical patency before initiating estrogen replacement therapy in women who have been menopausal for a substantial length of time.
authors.affiliation: Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC.
authors.forename: P C
authors.initials: PC
authors.lastname: Sacks
authors.forename: R J
authors.initials: RJ
authors.lastname: Falk
mesh_terms: D000368:Aged; D003251:Constriction, Pathologic; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000172:deficiency; D005260:Female; D006409:Hematometra / Q000209:etiology*; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D013997:Time Factors; D002577:Uterine Cervical Diseases / Q000150:complications* / Q000473:pathology
chemical_list: D004967:Estrogens