Attenuation of 8-OH-DPAT induced feeding after lesions of the area postrema/immediately adjacent nucleus of the solitary tract.
Rats with lesions of the area postrema/immediately adjacent nucleus of the solitary tract (AP/mNTS-lesions) have an attenuated feeding response after several manipulations that induce food intake in intact control rats. In this study we examined the ingestive response of rats with AP/mNTS-lesions after treatment with 8-OH-DPAT, a 5-HT1A agonist. Rats with AP/mNTS-lesions failed to increase their food intake after treatment with 8-OH-DPAT at doses that stimulated food intake in intact rats. These data suggest that altered serotonergic function may contribute to the attenuation of feeding observed in rats with AP/mNTS-lesions after treatment with some orexigenic stimuli.
Edwards
G L
GL
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Power
J D
JD
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000037:antagonists & inhibitors*; D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin