[A comparison of the effects of haloperidol when administered systemically and injected into the striatum of rats].
The effects of chronic intraperitoneal (2 mg/kg) and bilaterally intrastriatal (5 micrograms) haloperidol were studied in albino male rats. Intraperitoneal injections resulted in inhibition of conditioned avoidance reflexes and catalepsy. After intrastriatal microinjections, the Parkinsonism-like status appeared along with akinesia and rigidity; that effect was recorded on day 7 of the experiment, which lasted up to the first few days of haloperidol withdrawal. The causes of distinctions between the effects of systemic and local intrastriatal haloperidol injections are discussed.
Iakimovskiĭ
A F
AF
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D003214:Conditioning, Classical / Q000187:drug effects; D003342:Corpus Striatum; D004558:Electric Stimulation; D006220:Haloperidol / Q000008:administration & dosage* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D008845:Microinjections / Q000379:methods; D009127:Muscle Rigidity / Q000139:chemically induced; D051381:Rats; D013997:Time Factors
D006220:Haloperidol
Sravnenie éffektov galoperidola pri sistemnom vvedenii i in''ektsii v striatum u krys.