Dysembryoplastic neuroepithelial micro-tumor in a 75-year-old patient with long-standing epilepsy.
Dysembryoplastic neuroepithelial tumors (DNT) are rare, cortically located neoplasma associated with intractable partial complex seizures. This entity was first described by Daumas-Duport et al. [1988], who also coined the term DNT. In that report, at the time of operation, the patients' ages ranged from 3 to 30 years and the duration of symptoms ranged from 2 to 18 years. In contrast, we observed a histologically comparable tumor in a 75-year-old female with a 60 year epilepsy history. Autopsy revealed an 8 mm large tumor in the right hippocampus. In view of the extremely prolonged course of the patient's symptoms and the complete lack of excessive cell proliferation, the differentiation of a genuine tumor versus a hamartoma remains equivocal.
Gottschalk
J
J
Institute of Neuropathology, Free University of Berlin, Germany.
Korves
M
M
Skotzek-Konrad
B
B
Goebel
S
S
Cervós-Navarro
J
J
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D019965:Neurocognitive Disorders / Q000473:pathology*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology*; D009454:Neurofibrils / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology*
D014408:Biomarkers, Tumor