Mutation, cancer and transgenic models: relevance to the toxicology industry.
The number and structural diversity of new compounds that are currently being introduced into the environment underlies the need to provide more sensitive toxicology tests. Ideally, these should involve tests that reduce dependence upon animal experimentation; over the past few years a step towards achieving this goal has arisen from the ability to construct transgenic animals. By the inclusion of a suitable marker gene or genetic predisposition to a given disease state, several potentially valuable new tests have become available. Here we assess the potential of these systems for use by the toxicologist and consider the future of this technology to the industry.
Sullivan
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Institute of Biotechnology, University of Cambridge, UK.
Gatehouse
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Tweats
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D000818:Animals; D030801:Animals, Genetically Modified; D015197:Carcinogenicity Tests; D004260:DNA Repair; D005819:Genetic Markers; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics*; D009857:Oncogenes; D013045:Species Specificity
D005819:Genetic Markers