Synthesis and local anesthetic activity of some derivatives of N,N-diethyl-2-(2-alkoxyphenylcarbamoyloxy)bornan-3-ylmethyl-ammonium chlorides.
A series of 8 new esters of 2-alkoxyphenyl-carbamoic acid were synthesized and assayed for local anesthetic activity. All compounds were isolated as hydrochlorides and their structure was proved by 1H-NMR 13C-NMR and IR spectroscopy. The index of anesthetic activity in infiltration and surface anesthesia proved that all prepared compounds are significantly more active than the standard reference compounds, procaine and cocaine, respectively; it is tightly correlated with the length of the alkoxy group. It was found that there is a parabolic relationship between log activity and molecular lipophilicity (as measured by RM). Toxicity of all compounds is within acceptable limits.
Gregán
F
F
Departement of Organic Chemistry, Faculty of Pharmacy, Bratislava, Czechoslovakia.
Kettmann
V
V
Novomesky
P
P
Racanska
E
E
Svec
P
P
D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001892:Camphanes / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003042:Cocaine / Q000494:pharmacology; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011343:Procaine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D011817:Rabbits; D012869:Skin Absorption
D000779:Anesthetics, Local; D001892:Camphanes; D008055:Lipids; D000644:Quaternary Ammonium Compounds; D011343:Procaine; D003042:Cocaine