title: The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
abstract: Rectal mucosal proliferation was measured in 116 individuals using the metaphase arrest technique crypt cell production rate (CCPR). CCPR was found to be significantly elevated in individuals with adenomas (n = 42, CCPR = 13 cc c-1h-1, range 7-25 Cl 10-15) compared with normals (n = 21, CCPR = 10 cc c-1h-1 range 5-24 Cl 7-11, Mann-Whitney P = 0.001 z = 3.2). Mucosal proliferation was increased among individuals who were undergoing adenoma follow up but in whom no further adenomas were found (n = 37 CCPR = 12 range 5-26 cc c-1h-1 Cl 10-14) compared to controls (Mann-Whitney P = 0.01 z = 2.4) Proliferation in vegetarians i.e. low risk (n = 16) was similar to controls. Measurement of proliferative indices in rectal mucosa by the stathmokinetic technique CCPR can discriminate between high and low risk groups for colorectal cancer.
authors.affiliation: Department of Surgery, University Hospital, Nottingham, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Rooney
authors.forename: P A
authors.initials: PA
authors.lastname: Clarke
authors.forename: K A
authors.initials: KA
authors.lastname: Gifford
authors.forename: J D
authors.initials: JD
authors.lastname: Hardcastle
authors.forename: N C
authors.initials: NC
authors.lastname: Armitage
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D001706:Biopsy; D002455:Cell Division; D003110:Colonic Neoplasms / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000473:pathology; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology*; D012007:Rectum / Q000166:cytology / Q000473:pathology*; D012307:Risk Factors; D014407:Tumor Cells, Cultured