title: Occupational dust exposure and chronic obstructive pulmonary disease. A systematic overview of the evidence.
abstract: The object of this study was to assess the relationship between occupational dust exposure and chronic obstructive pulmonary disease (COPD). Studies were identified using MEDLINE (January 1966 to July 1991), SCISEARCH, manual review of reference lists, and personal contact with more than 30 international experts. Studies of COPD, lung function, emphysema, chronic bronchitis, or mortality in workers exposed to nonorganic dust were retrieved. Studies were included if dust exposure was measured quantitatively, and a quantitative relationship between dust exposure and one of the outcomes of interest was calculated while controlling at least for smoking and age. Methodological rigor was assessed, and data regarding the study populations, prognostic factors, and outcomes were extracted independently by two reviewers. Thirteen reports derived from four cohorts of workers met our inclusion criteria. Three of the cohorts were of coal miners and one was of gold miners. All of the studies found a statistically significant association between loss of lung function and cumulative respirable dust exposure. It was estimated that 80 (95% CI, 34 to 137) of 1,000 nonsmoking coal miners with a cumulative respirable dust exposure of 122.5 gh/m3 (considered equivalent to 35 years of work with a mean respirable dust level of 2 mg/m3) could be expected to develop a clinically important (> 20%) loss of FEV1 attributable to dust. Among 1,000 smoking miners the comparable estimate was 66 (95% CI, 49 to 84). The risk of a clinically important loss of lung function attributable to dust among nonsmoking gold miners was estimated to be three times as large as for coal miners at less than one fifth of the cumulative respirable dust exposure (21.3 gh/m3), the maximal exposure observed among the cohort of gold miners. We conclude that occupational dust is an important cause of COPD, and the risk appears to be greater for gold miners than for coal miners. One possible explanation of the greater risk among gold miners is the higher silica content in gold mine dust.
authors.affiliation: Department of Family Medicine, Clinical Epidemiology & Biostatistics, and Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Oxman
authors.forename: D C
authors.initials: DC
authors.lastname: Muir
authors.forename: H S
authors.initials: HS
authors.lastname: Shannon
authors.forename: S R
authors.initials: SR
authors.lastname: Stock
authors.forename: E
authors.initials: E
authors.lastname: Hnizdo
authors.forename: H J
authors.initials: HJ
authors.lastname: Lange
mesh_terms: D001991:Bronchitis / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D004391:Dust / Q000009:adverse effects*; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D016239:MEDLINE; D009784:Occupational Diseases / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D016273:Occupational Exposure / Q000009:adverse effects*; D011656:Pulmonary Emphysema / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects / Q000401:mortality / Q000503:physiopathology; D014481:United States
chemical_list: D004391:Dust