title: Ranitidine 300 mg at bedtime is effective for gastric ulcers: a 12-wk, multicenter, randomized, double-blind, placebo-controlled comparison. The Ranitidine 300 mg HS Gastric Ulcer Study Group.
abstract: Ranitidine 150 mg twice daily is effective for the treatment of gastric ulcers. We proposed that ranitidine 300 mg once daily would also be effective. In a randomized, double-blind, placebo-controlled, multicenter, parallel-group study, adults with an endoscopically verified acute gastric ulcer > or = 5 mm were treated with either ranitidine 300 mg (n = 183) or placebo (n = 178) at bedtime for up to 12 wk. Gastric ulcer healing, determined by endoscopy, was achieved in 65% and 89% of ranitidine-treated patients by 6 and 12 wk, compared with 45% and 72% of placebo-treated patients by 6 wk and 12 wk (p < 0.001). Throughout the 12-wk study, ranitidine 300 mg was significantly more effective than placebo in relieving pain (p < 0.05), with ranitidine-treated patients also using fewer antacid tablets. Ranitidine 300 mg had a safety profile similar to that of placebo. We conclude that ranitidine 300 mg at bedtime is safe and effective for healing acute gastric ulcers.
authors.affiliation: Glaxo Pharmaceuticals, Research Triangle Park, North Carolina.
authors.forename: J A
authors.initials: JA
authors.lastname: Johnson
authors.forename: A R
authors.initials: AR
authors.lastname: Euler
authors.forename: A R
authors.initials: AR
authors.lastname: Northcutt
authors.forename: D J
authors.initials: DJ
authors.lastname: McSorley
mesh_terms: D000208:Acute Disease; D000863:Antacids; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000008:administration & dosage* / Q000009:adverse effects; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D000863:Antacids; D011899:Ranitidine