title: Pharmacokinetics of propofol in mixed-breed dogs and greyhounds.
abstract: Pharmacokinetics and recovery characteristics of propofol in Greyhounds and mixed-breed dogs were compared. In all dogs, disposition of propofol was adequately described by a 2-compartment open model, with a rapid distribution phase followed by a slower elimination phase. When findings in Greyhounds were compared with those in mixed-breed dogs, significant differences were observed in mean concentrations of propofol in blood, recovery characteristics, and estimates for apparent volume of distribution, volume of distribution at steady state, and total body clearance. In addition, Greyhounds recovered from anesthesia at higher concentrations of propofol than did mixed-breed dogs. A secondary peak in blood propofol concentration was observed in 8 of 10 Greyhounds and in 5 of 8 mixed-breed dogs. This peak corresponded to the time of return of the righting reflex.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011.
authors.forename: D L
authors.initials: DL
authors.lastname: Zoran
authors.forename: D H
authors.initials: DH
authors.lastname: Riedesel
authors.forename: D C
authors.initials: DC
authors.lastname: Dyer
mesh_terms: D000818:Animals; D004285:Dogs / Q000378:metabolism*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013045:Species Specificity; D013997:Time Factors
chemical_list: D015742:Propofol