Subcellular alterations of cardiac fibers in rats subjected to hypothyroidism.
Subcellular changes of the atrial cardiomyocytes of rats submitted to hypothyroidism caused by administration of 1 mg/100 g of body weight of propylthiouracil showed a) swollen mitochondria and lysis of their cristae; b) myofibrils with marked heterogeneity of patterns, some exhibiting rupture and loss of continuity of their myofilaments; c) lesser concentration of atrial granules in the perinuclear area; d) abundant granular interstitial tissue and collagen separating the myofibrils.
Lopes
A C
AC
Department of Internal Medicine, School of Medicine, São Paulo, Brasil.
Furlanetto
R
R
Sasso
W S
WS
Didio
L J
LJ
D000818:Animals; D003094:Collagen; D003238:Connective Tissue / Q000187:drug effects; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects*; D007037:Hypothyroidism / Q000139:chemically induced / Q000473:pathology*; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000648:ultrastructure; D009210:Myofibrils / Q000187:drug effects / Q000648:ultrastructure; D011441:Propylthiouracil; D051381:Rats; D011919:Rats, Inbred Strains
D011441:Propylthiouracil; D003094:Collagen