Enterococcus faecalis: in vitro activity of antimicrobial drugs, singly and combined, with and without defibrinated human blood, against high-level-gentamicin-resistant isolates.
Teicoplanin (4 micrograms/ml) combined with 4 micrograms/ml of ampicillin, mezlocillin, and piperacillin, respectively, proved more efficacious than vancomycin (4 micrograms/ml) combined with the three beta-lactam antibiotics against three representative clinical isolates of Enterococcus faecalis that showed high-level-gentamicin resistance (HLGR). In the presence of 65% (v/v) of fresh defibrinated human blood, teicoplanin (4 micrograms/ml) alone afforded significant bactericidal activity, but failed to completely sterilize assay tube contents, whereas teicoplanin combined with any of the three beta-lactam antibiotics consistently and completely killed HLGR E. faecalis inocula.
Traub
W H
WH
Institut für Medizinische Mikrobiologie und Hygiene, Universität des Saarlandes, Homburg/Saar, BRD.
Leonhard
B
B
Bauer
D
D
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001769:Blood; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008802:Mezlocillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D005839:Gentamicins; D017334:Teicoplanin; D014640:Vancomycin; D000667:Ampicillin; D008802:Mezlocillin; D010878:Piperacillin