title: Evaluation of secondary prophylactic schemes, based on benzathine penicillin G, for rheumatic fever in children.
abstract: Serum concentrations of penicillin were measured in children with rheumatic fever. The adequacy of the values after administration of 1.2 million units of benzathine penicillin G every 2 or 3 weeks was confirmed; the adequacy of a 4-week regimen was questionable. The administration of 0.6 million units every 3 weeks was found to be inadequate to maintain serum levels high enough for the secondary prophylaxis of rheumatic fever.
authors.affiliation: Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Meira
authors.forename: C de C
authors.initials: Cde C
authors.lastname: Mota
authors.forename: E
authors.initials: E
authors.lastname: Tonelli
authors.forename: E A
authors.initials: EA
authors.lastname: Nunan
authors.forename: A M
authors.initials: AM
authors.lastname: Mitre
authors.forename: N S
authors.initials: NS
authors.lastname: Moreira
mesh_terms: D000293:Adolescent; D001938:Brazil; D002648:Child; D006801:Humans; D010401:Penicillin G Benzathine / Q000008:administration & dosage* / Q000097:blood; D012213:Rheumatic Fever / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D010401:Penicillin G Benzathine