title: The effects of local ventricular pacing on recovery from regional myocardial ischemia.
abstract: After surgical revascularization of ischemic myocardium, temporary ventricular pacing is often used, yet no data exist to indicate whether pacing ischemic versus nonischemic myocardium affects myocardial recovery. Therefore, chronically instrumented conscious dogs were studied with segment length transducers in the left anterior descending (LAD) distribution, left ventricular and pericardial micromanometers, pneumatic occluders on the LAD and venae cavae, and bipolar ventricular pacing wires, one pair in the LAD zone and one pair in the nonischemic (LCX) zone. Six dogs underwent a total of twelve 15-min LAD occlusions, each followed by 48 hr of reperfusion. Just after reperfusion, either the LAD or LCX zone was paced at 150 bpm for 45 min. LAD versus LCX pacing decreased regional stroke work (6 +/- 5 versus 19 +/- 5 kerg.cm-2) and produced contractile asynchrony. Myocardial contractile function was assessed using preload recruitable work area (PRWA), the area under the regional stroke work versus end-diastolic length relationship. Relative to LCX pacing, LAD pacing significantly delayed the recovery of PRWA after 4 hr of reperfusion (54 +/- 9 versus 83 +/- 9% control PRWA, P < 0.05). Perhaps by increased contractile asynchrony despite the decreased regional stroke work, ventricular pacing of ischemically injured myocardium delays functional recovery and should be avoided in clinical settings where the ventricular pacing site may be chosen.
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: C W
authors.initials: CW
authors.lastname: Lewis
authors.forename: C H
authors.initials: CH
authors.lastname: Owen
authors.forename: D A
authors.initials: DA
authors.lastname: Zipprich
authors.forename: D C
authors.initials: DC
authors.lastname: Sabiston
authors.forename: P K
authors.initials: PK
authors.lastname: Smith
authors.forename: D D
authors.initials: DD
authors.lastname: Glower
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D006439:Hemodynamics; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D016276:Ventricular Function