Genetic differences in progestin sensitivity in CD-1 and SW female mice.
The lordotic behavior of ovariectomized CD1 and SW female mice was tested in response to estradiol benzoate(EB)+progesterone (P) or EB + 5 alpha-dihydroprogesterone (DHP) to determine (i) the role of progestin metabolism in the regulation of sexually receptive behavior, and (ii) strain differences in sensitivity to these progestins. A greater proportion of SW females resisted mounting attempts than CD-1 females, regardless of the progestin administered. However, the differences in mounting were not correlated with the expression of lordotic behavior. A greater proportion of SW females exhibited sexually receptive behavior when given EB+P in comparison to the CD-1 females. There were no genotypic differences in lordotic behavior in response to EB+DHP. The potential mechanisms mediating genotype-based differences in responsiveness are discussed, and the relationship of this report to previously described strain differences in progestin sensitivity are considered.
McKenna
S E
SE
Department of Psychology, Lehigh University, Bethlehem, PA 18015.
Simon
N G
NG
D004092:20-alpha-Dihydroprogesterone / Q000494:pharmacology*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011374:Progesterone / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012931:Social Environment; D013045:Species Specificity
D004092:20-alpha-Dihydroprogesterone; D011374:Progesterone; D004958:Estradiol