title: Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization.
abstract: Helicobacter pylori infection of human gastric epithelium has been associated with gastritis, ulcers and gastric cancers. In an H. felis, germ-free mouse model of infection, oral immunization with bacterial antigens plus cholera toxin resulted in elevated serum, gastric and intestinal anti-H. felis antibody titres and protection from acute infection. Mice given monoclonal IgA anti-H. felis antibody at the time of initial challenge were also protected from infection. These results demonstrate that oral vaccination may be a feasible approach for the prevention of H. pylori infection of humans.
authors.affiliation: Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106.
authors.forename: S J
authors.initials: SJ
authors.lastname: Czinn
authors.forename: A
authors.initials: A
authors.lastname: Cai
authors.forename: J G
authors.initials: JG
authors.lastname: Nedrud
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D016998:Helicobacter / Q000276:immunology*; D016481:Helicobacter Infections / Q000517:prevention & control*; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000276:immunology*; D051379:Mice; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A