[Morphological studies on liver in septic state by mice with E. coli injection into the abdominal cavity].
The purpose of this study is to elucidate morphological changes in septicemic mice induced by an injection of E. coli into the abdominal cavity and to discuss the relationship between the clinical findings and morphological ones. The liver of septicemic mice was morphologically demonstrated, a) Kupffer cells entrapped bacteria and erythrocytes, and large lysosomes were found in Kupffer cells, b) hepatocytes with low dense cytosol increased, and in the hepatocytes, many conglomerations of lysosome and cytolysome, and degeneration of rER, sER and mitochondria were identified, c) intercellular bile canaliculus became narrow. The conclusion is as follows: 1) the increase of the serum level of T. bili is caused by the increase of the phagocyte of erythrocytes by Kupffer cells and by the dysfunction of bile transformation and transportation in hepatocytes, 2) the increase of the serum level of GOT, GPT and LDH is caused by the degeneration of mitochondria in hepatocytes, 3) the decrease of the capacity to synthesize protein and lipid is due to the degeneration of cell organelles in hepatocytes.
Kodama
H
H
Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
Morishita
Y
Y
Anzai
T
T
D000818:Animals; D016470:Bacteremia / Q000473:pathology* / Q000503:physiopathology; D001652:Bile Ducts / Q000503:physiopathology; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D007728:Kupffer Cells / Q000502:physiology; D008099:Liver / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D008815:Mice, Inbred Strains