Synthesis of 3-oxa-5-alkylideneisocarbacyclins.
3-Oxa-5-methyleneisocarbacyclin (14a) and 3-oxa-5-ethylideneisocarbacyclin (19a) were synthesized. Compound 14a showed a potent antiplatelet aggregating activity, whereas 19a was inactive.
Kojima
K
K
Medicinal Chemistry Research Laboratory, Sankyo Co., Ltd., Tokyo, Japan.
Amemiya
S
S
D000818:Animals; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D010975:Platelet Aggregation Inhibitors; C041946:9-O-methanoprostaglandin I; D011464:Epoprostenol