title: Identification of populations at risk in drug testing and therapy: application to elderly patients.
abstract: Risks associated with drug therapy are more prevalent with advancing age. In drug evaluation it is imperative to identify risk groups. Six strategies are discussed to identify risk groups: (a) from physico-chemical, preclinical drug data, and expected physiologic changes; (b) from animal and human phase I PK data and expected physiologic changes; (c) from epidemiologic data and expected physiological changes; (d) from animal/human toxicokinetic data and expected physiologic changes; (e) from retrospective patient monitoring; (f) from population kinetics using NONMEM; and (g) from pharmacokinetic screen approach.
authors.affiliation: University of Cincinnati Medical Center, Ohio 45267-0004.
authors.forename: W A
authors.initials: WA
authors.lastname: Ritschel
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D010599:Pharmacokinetics; D012307:Risk Factors