title: Pyruvate supplementation of a low-cholesterol, low-fat diet: effects on plasma lipid concentrations and body composition in hyperlipidemic patients.
abstract: The effects of the three-carbon compound pyruvate on plasma lipid concentrations and body composition were evaluated in hyperlipidemic patients consuming a low-cholesterol (165-180 mg), low-fat (22-24% of energy; 18-20% of energy as saturated fatty acid) diet (0.091-0.099 MJ.kg body wt-1 x d-1). After consuming the above diet for 4 wk, during which time plasma lipid concentrations decreased, 34 subjects were randomly assigned to receive either 22-44 g pyruvate (n = 17) or 18-35 g polyglucose (placebo, Polycose, n = 17), iso-energetically substituted for a portion of carbohydrate energy for 6 wk. Despite greater weight and fat losses with pyruvate (P < 0.05), plasma concentrations of cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride were not different between the two groups of subjects. We conclude that subsequent to diet-induced reduction in plasma lipid concentrations, pyruvate supplementation of a low-cholesterol, low-fat diet providing 6.7-7.6 MJ/d for 6 wk has no effect on plasma lipid concentrations but enhances body weight and fat losses.
authors.affiliation: Department of Medicine, Montefiore University Hospital, Pittsburgh, PA 15213-2582.
authors.forename: R T
authors.initials: RT
authors.lastname: Stanko
authors.forename: H R
authors.initials: HR
authors.lastname: Reynolds
authors.forename: R
authors.initials: R
authors.lastname: Hoyson
authors.forename: J E
authors.initials: JE
authors.lastname: Janosky
authors.forename: R
authors.initials: R
authors.lastname: Wolf
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects*; D015992:Body Mass Index; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011773:Pyruvates / Q000494:pharmacology / Q000627:therapeutic use*; D019289:Pyruvic Acid; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000187:drug effects
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D008055:Lipids; D011773:Pyruvates; D014280:Triglycerides; D019289:Pyruvic Acid