title: A simple micromanipulator for multiple uses in freely moving rats: electrophysiology, voltammetry, and simultaneous intracerebral infusions.
abstract: An inexpensive, easily fabricated micromanipulator is described that can be used for single-unit recording or voltammetry in freely moving rats. The basic design is configured around the standard coupling system between a plastic syringe and corresponding needle hub. The device can be used with glass or metal microelectrodes for electrophysiology or carbon-fiber or carbon-disk microelectrodes for voltammetry. With either recording technique, the micromanipulator also can accommodate a 33-ga infusion cannula, which allows drugs to be administered directly to the recording site. The entire assembly is lightweight and can be used with a head-mounted amplifier system for relatively noise-free recording.
authors.affiliation: Department of Psychology, Indiana University, Bloomington 47405.
authors.forename: G V
authors.initials: GV
authors.lastname: Rebec
authors.forename: P E
authors.initials: PE
authors.lastname: Langley
authors.forename: R C
authors.initials: RC
authors.lastname: Pierce
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: B A
authors.initials: BA
authors.lastname: Heidenreich
mesh_terms: D000200:Action Potentials; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation*; D007267:Injections / Q000295:instrumentation*; D008839:Microelectrodes; D008846:Micromanipulation / Q000295:instrumentation*; D051381:Rats; D013238:Stereotaxic Techniques; D013594:Syringes