title: Human auditory cortical mechanisms of sound lateralization: II. Interaural time differences at sound onset.
abstract: Neuromagnetic responses were recorded over the right temporal cortex using a 24-channel gradiometer. Stimuli were binaural click trains, presented with six separate interaural time differences (ITDs). N100m to sound onset was larger and earlier for stimuli presented with left- than with right-leading ITDs. With stimulus lateralization taken into account, monaural and binaural stimuli evoked responses of roughly equal amplitude. In selective adaptation and oddball experiments, stimuli presented with different ITDs excited overlapping neuronal populations, but the amount of overlap decreased as the ITD between the stimuli increased. There were no systematic differences in the cortical source locations of the N100m as a function of ITD, however. Thus it appears that ITD-sensitive neurons in the human auditory cortex are not organized into a large-scale, orderly representation, which could be resolved by MEG.
authors.affiliation: Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland.
authors.forename: L
authors.initials: L
authors.lastname: McEvoy
authors.forename: R
authors.initials: R
authors.lastname: Hari
authors.forename: T
authors.initials: T
authors.lastname: Imada
authors.forename: M
authors.initials: M
authors.lastname: Sams
mesh_terms: D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D013017:Sound Localization / Q000502:physiology*; D013997:Time Factors