[Neonatal blood IgE levels on filter paper as indicators of atopic disease--a follow-up at the age 18 months and 5 years].
Measurements of IgE levels in the blood of neonates were investigated using filter paper for blood collection in mass screening of congenital metabolic disorders by time-resolved fluoroimmunometric assay. In an analysis of the present result, IgE value of at least 0.015 U/ml, the measurement limit, were considered as high. High IgE levels in filter paper blood were seen in 28 (7.2%) of the 389 cases. When the relation with serum IgE levels at 18 months of age was investigated in 134 of 389 subjects, high serum IgE levels were also found in 86.7% of the subjects with high IgE levels in filter paper blood. In addition, when the relation between family history of atopic disease and presence of atopic disease in the first 18 months of age was investigated in 203 of the 389 subjects, 90% of the subjects with a family history of atopic disease and high IgE levels in filter paper blood developed atopic disease. On the other, 50% and 24.7% of the subjects with low IgE levels in filter paper blood and an atopic family history or no atopic family history, developed atopic disease, respectively. There were significant differences among these three groups (p < 0.01). When the relation between IgE levels in filter paper blood and presence of atopic disease in the first 5 years of age was investigated in 87 of the 389 subjects. 95% of the subjects with high IgE levels in filter paper blood developed atopic disease, though 57% of the subjects with low IgE levels developed atopic disease.(ABSTRACT TRUNCATED AT 250 WORDS)
Nakachi
S
S
Department of Pediatrics, Juntendo University School of Medicine.
D002675:Child, Preschool; D005260:Female; D005374:Filtration; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis*; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012680:Sensitivity and Specificity
D007073:Immunoglobulin E