[Acute radiation cerebral disorders as an effect of neuronal DNA damage].
Early transient incapacity and cerebral radiation syndrome were shown to result from the de-energizing of the brain due to NAD and ATP neuron pools depletion since DNA breaks stimulate the repair enzyme, ADP-ribosyltransferase, that consumes NAD as a substrate. The phenomenology of syndromes, peculiarities of the CNS repair and neutron RBE might be attributed to this mechanism. DNA is thus a common target for stochastic, deterministic and physiological effects of radiation.
Malakhovskiĭ
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VN
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D001927:Brain Diseases / Q000209:etiology* / Q000378:metabolism; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000150:complications* / Q000378:metabolism
D004247:DNA
Ostrye luchevye tserebral'nye narusheniia kak éffekt povrezhdeniia DNK neĭronov.