title: [A case with pyramidal tract lesion suggesting Wallerian degeneration--analysis with diffusion coefficient].
abstract: We reported a 55-year-old man, whose T2-weighted MR images disclosed abnormal high signal band along the left pyramidal tract 6 months after cerebral infarction of the left centrum semiovale. Brain CT revealed low intensity areas in the centrum semiovale, the posterior limb of the internal capsule on left side. On T2-weighted MR images, there were an irregular high signal area on the left centrum semiovale, a high signal band from the left centrum semiovale to the medullary pyramid, and a high signal band from the left centrum semiovale to the cerebral cortex. These lesions were observed as high signal areas on proton weighted images and low signal areas on T1-weighted MR images. Diffusion coefficient perpendicular to the pyramidal tract in the patient, which was calculated from diffusion weighted images at the posterior limb of the internal capsule, was higher than that in normal individuals. Diffusion anisotropy at the lesion, which is the rate between the diffusion coefficient parallel and perpendicular to nerve fiber, was higher than that of normal individuals. These data suggested that the lesion had demyelinating process, which was consistent with the pathology at stage 2 of the Wallerian degeneration.
authors.forename: F
authors.initials: F
authors.lastname: Segawa
authors.forename: K
authors.initials: K
authors.lastname: Kamada
authors.forename: J
authors.initials: J
authors.lastname: Kishibayashi
authors.forename: N
authors.initials: N
authors.lastname: Sunohara
mesh_terms: D002544:Cerebral Infarction / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011712:Pyramidal Tracts / Q000473:pathology*; D014855:Wallerian Degeneration