Nonrespiratory rhythmic fluctuations in systemic arterial pressure in anesthetized humans.
OBJECTIVE
To clarify the frequency of nonrespiratory rhythmic fluctuations in systemic arterial pressure (vasomotor waves) and to identify the clinical conditions in which the vasomotor waves develop in humans under anesthesia.


METHODS
Retrospective analysis of collected data.


METHODS
Inpatient surgery clinic at a university hospital.


METHODS
Five hundred thirteen consecutive ASA physical status II-V patients.


METHODS
Direct arterial pressure monitoring and general anesthesia, including high-dose fentanyl, enflurane, enflurane plus fentanyl, cervical or thoracic epidural, and lumbar epidural anesthesia.


RESULTS
Among the anesthesia techniques used, vasomotor waves occurred most frequently in patients anesthetized with high-dose fentanyl (31.1%) and least frequently in those with high-level epidural blockade (7.4%). As a result of multiple logistic analysis, the contributing factors to the appearance of vasomotor waves were the institution of cardiopulmonary bypass (CPB) and the patient's age. It is also a novel finding that nearly one-third of the vasomotor waves developed in patients under stable hemodynamic conditions.


CONCLUSIONS
Vasomotor waves are a common phenomenon in relatively high-risk patients during general anesthesia. The appearance of vasomotor waves is significantly related to CPB and patient age.
Ishizawa
Y
Y
Department of Anesthesiology, University of Tsukuba, Japan.
Dohi
S
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000601:surgery; D002302:Cardiac Output / Q000502:physiology; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012119:Respiration; D012189:Retrospective Studies; D014666:Vasomotor System / Q000502:physiology*
D005283:Fentanyl