title: Postprandial release of glucagon-like peptide-1, pancreatic glucagon, and insulin after esophageal resection.
abstract: Postprandial concentrations of glucose and the immunoreactivity of insulin, glucagon-like peptide-1 (GLP-1), and pancreatic glucagon were measured in 10 patients who had undergone esophageal resection (ER) and replacement by the stomach. Emptying of the esophageal substitute was assessed by scintigraphy using a 99Tc-labeled solid test meal. The data were compared with measurements performed in 14 controls, in 7 of whom gastric emptying was measured. The gastric emptying half time was 6.8 +/- 6.2 min (median 144 s) in ER cases, significantly shorter than in controls: 70 +/- 29 min (median 51 min). The early integrated (first 30 min) and total integrated insulin and GLP-1 concentrations were significantly higher than in controls. In 3 of 10 esophagectomy patients the blood glucose concentration fell below 3.8 mmol/l postprandially. High GLP-1 concentrations in the first 30 min were associated with low serum glucose during the 2nd h postprandially when all the hypoglycemic episodes occurred. It is concluded that rapid emptying of the esophageal substitute induces the exaggerated GLP-1 response, which is a main factor for reactive hypoglycemia.
authors.affiliation: Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, BRD.
authors.forename: J
authors.initials: J
authors.lastname: Miholic
authors.forename: C
authors.initials: C
authors.lastname: Orskov
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
authors.forename: J
authors.initials: J
authors.lastname: Kotzerke
authors.forename: R
authors.initials: R
authors.lastname: Pichlmayr
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D004435:Eating / Q000502:physiology; D004938:Esophageal Neoplasms / Q000601:surgery*; D004944:Esophagoplasty; D004947:Esophagus / Q000601:surgery*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D005934:Glucagon / Q000097:blood*; D052216:Glucagon-Like Peptide 1; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D013270:Stomach / Q000601:surgery
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon