title: Calcium fluoride formation in enamel from semi- or low-concentrated F agents in vitro.
abstract: The formation of CaF2 was measured on sound enamel and in artificial, standardized (acidified gelatin, pH 4.5) caries-like enamel lesions after exposure to: (a) dentifrice/saliva slurries adjusted to relevant F-concentrations of approximately 100 or 8 ppm by appropriate addition of 1,000 ppm F NaF or Na monofluorophosphate (MFP) dentifrice, respectively, or (b) a mixture of saliva with a 0.2% NaF solution obtained by a usual 1-min rinse procedure or an aqueous solution of 0.2% NaF. CaF2 was determined after extraction with KOH and fluoride analysis by gas chromatography. Only negligible amounts of CaF2 were produced on sound enamel ranging from (mean +/- SEM) 0.76 +/- 0.14 micrograms F/cm2 with the 0.2% NaF solution to as little as 0.04 +/- 0.06 with the MFP dentifrice slurry. In caries-like enamel lesions, the CaF2 production with the 0.2% NaF solution/saliva mixture corresponded to 3.7 +/- 0.4 micrograms F/cm2 and corresponding amounts obtained with the dentifrice/saliva slurries were 1.5 +/- 0.19 micrograms F/cm2 with NaF, but only 0.19 +/- 0.04 with MFP. It was suggested that the deposition of CaF2 in the micropores of early lesions can be expected to be an important mechanism with F rinses, probably to some extent with NaF dentifrices, but barely with MFP dentifrices. The formation of CaF2 on sound enamel is unlikely to play a significant role in the caries-reducing effect of F rinses and F dentifrices.
authors.affiliation: Department of Cardiology and Endodontics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Bruun
authors.forename: H
authors.initials: H
authors.lastname: Givskov
mesh_terms: D002124:Calcium Fluoride / Q000737:chemistry / Q000378:metabolism*; D011232:Chemical Precipitation; D003731:Dental Caries / Q000378:metabolism*; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism; D003802:Dentifrices; D005459:Fluorides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009067:Mouthwashes; D010710:Phosphates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D012463:Saliva / Q000502:physiology; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D003802:Dentifrices; D009067:Mouthwashes; D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D002124:Calcium Fluoride; D005459:Fluorides