title: Diffuse thickening superimposed on circumscribed pleural thickening related to asbestos exposure.
abstract: Circumscribed and diffuse pleural thickening (PT), the most common radiographic manifestations of asbestos-related disease, have different pathogeneses, differential diagnostic criteria, and effects on pulmonary function. The important distinction between the two disorders is demonstrated by six patients in whom typical circumscribed PT was followed by diffuse PT in the same hemithorax. The diffuse PT came on 18-47 (mean 32.3) years after first exposure to asbestos. In four patients, clinically evident pleural effusions preceded the diffuse PT; the latter left all with moderate to severe restrictive ventilatory impairment. Patients with stable pleural plaques are at risk for diffuse PT and consequent greater ventilatory impairment, even though they are many years from first exposure to asbestos.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: A
authors.initials: A
authors.lastname: Miller
authors.forename: J A
authors.initials: JA
authors.lastname: Miller
mesh_terms: D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D001195:Asbestosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010994:Pleura / Q000000981:diagnostic imaging / Q000473:pathology*; D010996:Pleural Effusion / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D011859:Radiography; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D001194:Asbestos