[Effect of baoyuantang on level of serum lipid peroxide and vitamin E in chronic glomerulonephritis].
Serum lipid peroxide (LPO) and vitamin E (VE) were determined in 18 patients with chronic glomerulonephritis (CGN) before and after treatment with Baoyuantang (BYT). It was found that before treatment the level of serum LPO (4.89 +/- 1.85 mumol/L) was higher, while the content of serum VE (4.27 +/- 1.84 micrograms/ml) was lower than those of normal controls (3.36 +/- 0.59 mumol/L, P < 0.001; 7.03 +/- 0.69 microgram/ml, P < 0.05). After treatment with BYT, the level of LPO lowered to 3.76 +/- 1.49 mumol/L, P < 0.05, as compared with the value before treatment, while the content of VE was increased to 5.33 +/- 2.45 micrograms/ml, but without statistical significance. A negative correlation was found between LPO level and VE content both before and after treatment (r = -0.495,P < 0.05; r = -0.522, P < 0.05). The results indicated chronic deficiency of VE in association with an increase in the level of LPO in the kidney in CGN patients and inhibition of LPO by BYT. After treatment complete remission was observed in 5 cases, basic remission in 3, and partial remission in 7.
Jin
Y P
YP
2nd Affiliated Hospital of Hunan Medical University, Changsha.
Yang
X L
XL
Wu
H
H
D000328:Adult; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014810:Vitamin E / Q000097:blood*; D016711:Yang Deficiency / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D014810:Vitamin E