title: Developmental expression of major myelin proteins in hypomyelinated pt mutant rabbit.
abstract: A term "paralytic tremor" (pt) is attributed to a neurological mutation of Chinchilla rabbits, affecting the development of the central nervous system (CNS). A quantification of myelin protein content indicates the strong CNS hypomyelination during the development (1-120 postnatal days). SDS-PAGE electrophoresis of total brain homogenates, followed by immunoblotting, shows a reduced concentration of major myelin-connected proteins. MBP deficiency corresponds approximately to the level of the hypomyelination, whereas PLP expression is drastically reduced.
authors.affiliation: Department of Neurochemistry, Medical Research Center, Polish Academy of Sciences, Warsaw.
authors.forename: J
authors.initials: J
authors.lastname: Sypecka
authors.forename: M
authors.initials: M
authors.lastname: Tosic
authors.forename: M
authors.initials: M
authors.lastname: Dolivo
authors.forename: K
authors.initials: K
authors.lastname: Domańska-Janik
authors.forename: J M
authors.initials: JM
authors.lastname: Matthieu
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry; D002682:Chinchilla; D003711:Demyelinating Diseases / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009185:Myelin Proteins / Q000096:biosynthesis*; D011817:Rabbits
chemical_list: D009185:Myelin Proteins