The ontogeny of immune responses.
It has been known for some years that a "window of opportunity" exists for transplantation in neonates. Patients who undergo transplantation during the first weeks of life usually have a very quiescent postoperative course. During fetal development a process of building tolerance to self-antigens occurs. It is now known that this "recognition of self" process is restricted by the major histocompatibility complex. Data will be presented that demonstrate that this major histocompatibility complex-restricted self-tolerance is the cause of the allogeneic effect. Thus when a transplantation is performed antigen presenting cells of the donor stimulate the T cells of the recipient to a very high degree. This stimulation is caused by presentation of monomorphic antigens in an inappropriate major histocompatibility complex environment. Loss of these antigen presenting cells can result in a quiescent transplantation course that represents the "window of opportunity" phenomenon. During the immediate postnatal period the infant possesses a naive immune system. One of the characteristics of this naiveté is a lack of class II expressing cells and a failure of appropriate antigen presentation. It will be suggested that this failure could contribute to the ease with which neonatal transplants can be immunosuppressed.
White
D J
DJ
Department of Surgery, University of Cambridge Clinical School, United Kingdom.
Gilks
W
W
D000375:Aging / Q000276:immunology*; D000818:Animals; D005333:Fetus / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006648:Histocompatibility; D006801:Humans; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D017634:Self Tolerance; D014019:Tissue Donors; D014181:Transplantation Immunology
D006680:HLA Antigens