Cardiac adaptation to one hour of mild regional low flow ischaemia in the pig.
OBJECTIVE
The aim was to determine the cardiac consequences of a 1 h period of mild regional low flow ischaemia in the pig heart.


METHODS
In eight pentobarbitone sodium anaesthetised pigs (weight range 23-38 kg), the mid left anterior descending coronary artery was constricted by a hydraulic occluder. Transmural coronary blood flow (Doppler flowmetry) was reduced to approximately 70% of control for 1 h. After complete release of the occluder cardiac function was monitored for 2 h. Left ventricular segment lengths were continuously recorded in the region subjected to low flow ischaemia and in a control region supplied by the circumflex artery.


RESULTS
After 1 h with a 28(SEM 3)% reduction in coronary blood flow, the systolic shortening index decreased from 100 to 68(7) (p < 0.001). This index transiently normalised upon reperfusion. Thereafter it declined, reaching a nadir of 72(5) at 1.25 h of reperfusion, and subsequently improved to 82(6) at 2 h of reperfusion.


CONCLUSIONS
Normalisation of local myocardial function appears during the first minutes of reperfusion after 1 h of mild low flow ischaemia and is followed by a period of stunning.
Offstad
J
J
Institute for Experimental Medical Research, University of Oslo, Ullevål Hospital, Norway.
Kirkebøen
K A
KA
Lande
K
K
Ilebekk
A
A
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D017682:Myocardial Stunning / Q000503:physiopathology; D013552:Swine; D013997:Time Factors