[Analysis of binding capacities between HLA class II molecules and synthetic peptides HA307-319].
MHC class II molecules control immune responses for T cell recognition of peptide antigens. In this study, we have examined the lymphocyte proliferative response (LPR) for HA307-319, a synthetic peptide, derived from hemagglutinin of a human influenza virus A strain, and the binding capacities of several DR and DQ molecules, which are frequently expressed in Japanese, with HA307-319. The high response of lymphocytes to HA307-319 was observed in DR1-positive subjects, and DR1 molecules had higher binding capacitise than DR2 and DR9 with the peptide. Also, three types of DQ molecules could bind weakly with HA307-319.
Ikeda
K
K
2nd Department of Pathology, Asahikawa Medical College, Japan.
Katagiri
M
M
D000595:Amino Acid Sequence; D002478:Cells, Cultured; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments; D010455:Peptides; C081942:influenza hemagglutinin (307-319)