Quantification of proteinuria: a re-evaluation of the protein/creatinine ratio for elderly subjects.
The difficulties of 24-hour urine collection are well recognized, especially for elderly people for whom a means of estimating protein excretion from a single casual unit sample would be preferable. We compared measurement of total urinary protein estimated by the protein/creatinine ratio with 24-h urine collection and examined the role of the ratio in discriminating between clinically important levels of proteinuria. Although the protein/creatinine ratio appeared to have an excellent correlation with the 24-h collection, the absolute agreement between the two methods was poor. However, the clinical role of the protein/creatinine ratio as a semi-quantitative test of proteinuria remained, provided adjustment for expected creatinine excretion was made.
Mitchell
S C
SC
Department of Health Care of Older People, Whittington Hospital, London.
Sheldon
T A
TA
Shaw
A B
AB
D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000652:urine*; D002940:Circadian Rhythm / Q000502:physiology; D003404:Creatinine / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000652:urine; D008297:Male; D011507:Proteinuria / Q000175:diagnosis / Q000652:urine*; D012016:Reference Values; D012737:Sex Factors
D001798:Blood Proteins; D003404:Creatinine