title: The effect of noradrenaline on mucociliary activity in the rabbit maxillary sinus.
abstract: The effect of noradrenaline (NA) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting it at increasing dosages (10(-11) to 10(-4) mol/kg) into the maxillary artery, the mucociliary response being recorded photoelectrically. NA increased mucociliary activity at a dosage of 10(-5) mol/kg, the maximal increase being 16.1 +/- 2.6%. The NA-induced stimulation of mucociliary activity had a latency of 20 s, and the activity returned to base-line level within 3 min. Pretreatment with the alpha-antagonist phentolamine (0.2 and 1.0 mg/kg) or the cholinergic antagonist atropine (1 mg/kg) did not alter mucociliary response to NA. Blockade with the beta-antagonist propranolol did not significantly reduce the maximal response to NA, which was 16.1 +/- 2.6% before and 11.1 +/- 3.0% after pretreatment with propranolol (n = 7; p = 0.2). In contrast, pretreatment with the prostaglandin-synthesis inhibitor indomethacin reduced the response from 12.9 +/- 2.9% to 6.3 +/- 1.3% (n = 6; p < 0.05), suggesting that at high dosages NA stimulates mucociliary activity via the cyclo-oxygenase pathway.
authors.affiliation: Department of Otorhinolaryngology, University Hospital, Lund, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Cervin
authors.forename: S
authors.initials: S
authors.lastname: Lindberg
authors.forename: U
authors.initials: U
authors.lastname: Mercke
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D008297:Male; D008443:Maxillary Sinus / Q000187:drug effects* / Q000378:metabolism; D009079:Mucociliary Clearance / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits
chemical_list: D001285:Atropine; D011433:Propranolol; D009638:Norepinephrine; D007213:Indomethacin; D010646:Phentolamine