title: [A trial of using the preparation difenin in the polycystic ovary syndrome].
abstract: Diphenin was administered to 59 patients with polycystic ovaries for 1 to 12 months. Eleven patients got pregnant and in 30 menstrual cycle normalized. Ovulation induction with human menopausal gonadotropins was more effective with less pronounced side effects. Hormonal tests after the treatment indicated decrease in LH, T, F plasma levels, LH/FSH ratio, decreased frequency and amplitude of LH pulse. Diphenin decreasing the activity of the central nervous system adrenergic structures, which is the major factor in the pathogenesis of polycystic ovaries syndrome, its administration is sufficient to cure this condition.
authors.forename: L D
authors.initials: LD
authors.lastname: Efremova
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D010672:Phenytoin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D010672:Phenytoin
vernacular_title: Opyt primeneniia preparata difenin pri sindrome polikistoznykh iaichnikov.