title: Mitotic Langerhans cell as a possible sign of activation in ichthyosis.
abstract: The fine structure of Langerhans cells (LC) in four rare types of ichthyosis, namely recessive ichthyosis congenita type II, III and IV and ichthyosis hystrix Curth-Macklin was examined. Signs of LC activation were observed in eight of 21 patients. In IC type IV, the rare occurrence of a mitotic LC was observed. It is possible that LCs are secondarily activated in keratinization disorders.
authors.affiliation: Section of Dermatology, Institute of Occupational Health, Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Kanerva
authors.forename: K M
authors.initials: KM
authors.lastname: Niemi
mesh_terms: D006801:Humans; D007057:Ichthyosis / Q000473:pathology*; D007801:Langerhans Cells / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008938:Mitosis