title: [Voluntary barium poisoning].
abstract: A 45-year-old man attempted to commit suicide by ingesting a large amount of barium. In some hours, he experienced generalized muscle weakness with hypokalaemia, treated by large dose of potassium (440 mmol in the first day). This weakness resulted in difficulties in swallowing and respiratory failure requiring mechanical ventilation. An anuric renal insufficiency started early, requiring haemodialysis for three weeks. It was induced probably by renal toxicity of barium and recovered completely. Later, the patient experienced an extrapyramidal syndrome initiated by tremor and myoclonia. Hypertonia induced a parkinsonian rheumatism, fixing the two hands in an irreducible position. There was also a contracture of superior sphincter of oesophagus, with severe disturbance of deglutition, ending after three months only. MRI study showed a bilateral hypersignal in basal ganglia and thalamus. It remains unknown whether this neurological syndrome was toxic or ischaemic. This patient remained under mechanical ventilation for three months because of disturbances of deglutition. He was discharged to his home at the 6th month. One year later he was still adynamic, but able to carry our rather precise movements.
authors.affiliation: Service de Réanimation, Centre Hospitalier, Chambéry.
authors.forename: J
authors.initials: J
authors.lastname: Fogliani
authors.forename: E
authors.initials: E
authors.lastname: Giraud
authors.forename: D
authors.initials: D
authors.lastname: Henriquet
authors.forename: B
authors.initials: B
authors.lastname: Maitrasse
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D017609:Barium Compounds / Q000506:poisoning*; D002712:Chlorides / Q000506:poisoning*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D011015:Pneumonia, Aspiration / Q000209:etiology; D011041:Poisoning / Q000628:therapy; D013406:Suicide, Attempted
chemical_list: D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride
vernacular_title: Intoxication volontaire par le baryum.