title: Pharmacological and pathological studies on Taiwan folk medicine (IX): The hepatoprotective effect of the methanolic extract from echinops grijisii.
abstract: In order to isolate the main hepatoprotective component of Echinops grijisii, the crude drug was extracted with methanol and subjected to continuous extractions using n-hexane chloroform, ethyl acetate and n-butanol. The hepatoprotective studies of each fraction from the methanol extract of E. grijisii was conducted in Wistar albino rats with CC(1)4-induced liver damage. Hepatoprotective activity was evaluated in terms of the modification of serum transaminase values such as SGOT and SGPT, and histopathological changes of liver biopsy. The results indicated that the main hepatoprotective component was concentrated in n-butanol and aqueous fractions.
authors.affiliation: School of Pharmacy, Kaohsiung Medical College, Taiwan.
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
mesh_terms: D020001:1-Butanol; D000085:Acetates; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D000440:Butanols; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D002725:Chloroform; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D000432:Methanol; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000085:Acetates; D000440:Butanols; D004365:Drugs, Chinese Herbal; C007650:ethyl acetate; D002725:Chloroform; D020001:1-Butanol; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000432:Methanol