Granulocyte-macrophage colony-stimulating factor and interleukin-1 increase in cerebrospinal fluid, but not in serum, of HTLV-I-associated myelopathy.
Based on our previous finding of elevated interferon-gamma levels in the cerebrospinal fluid (CSF), but not in serum, of HTLV-I-associated myelopathy (HAM), we assayed serum and CSF levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in 20 HAM. GM-CSF and IL-1 also increased only in the CSF in 75% and 35%, respectively, of 20 HAM. TNF-alpha was not detected in any of the sera and CSFs. Multiple cytokines may be produced in the central nervous system and play an important role in HAM.
Kuroda
Y
Y
Department of Internal Medicine (Section of Neurology), Saga Medical School, Japan.
Matsui
M
M
Takashima
H
H
Kurohara
K
K
D000328:Adult; D000368:Aged; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000097:blood* / Q000134:cerebrospinal fluid*; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000378:metabolism
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor