title: Reversal of aluminum-related bone disease after renal transplantation.
abstract: We evaluated the course of severe aluminum-related bone disease (ARBD) after the first year of a successful renal transplantation (RTx) in 11 adult patients. Bone pain and muscle weakness, presented in all patients previously to RTx, subsided, and all were able to walk, even the ones who were confined to wheelchairs. Bone necrosis developed in 6 patients, but none required surgical repair. Serum alkaline phosphatase activity increased 2.5 times the upper normal level, up to the 5th month and then declined to normal levels up the 12th month (p < 0.05). The inverse profile was observed in both serum calcium and phosphorus levels. In bone biopsies, there was a significant decrease in all of the following histomorphometric static parameters: osteoid volume, thickness and surface and also in aluminum surface. Also, there was a significant increase in all the dynamic parameters of mineralization: mineral apposition rate, mineralization surface, bone formation rate and adjusted apposition rate. In conclusion, ARBD remarkably improves after 1 year of successful RTx.
authors.affiliation: Transplantation Unit, Hospital das Clínicas, Faculdade de Medicina, University of Sao Paulo, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: David-Neto
authors.forename: V
authors.initials: V
authors.lastname: Jorgetti
authors.forename: N M
authors.initials: NM
authors.lastname: Soeiro
authors.forename: R C
authors.initials: RC
authors.lastname: Pereira
authors.forename: A
authors.initials: A
authors.lastname: Borelli
authors.forename: L E
authors.initials: LE
authors.lastname: Ianhez
authors.forename: E
authors.initials: E
authors.lastname: Sabbaga
authors.forename: B L
authors.initials: BL
authors.lastname: Wajchemberg
authors.forename: S
authors.initials: S
authors.lastname: Arap
mesh_terms: D000328:Adult; D000535:Aluminum / Q000378:metabolism*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002113:Calcification, Physiologic; D002118:Calcium / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis; D010018:Osteomalacia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010758:Phosphorus / Q000097:blood; D011184:Postoperative Period; D011446:Prospective Studies
chemical_list: D010758:Phosphorus; D003404:Creatinine; D000535:Aluminum; D002118:Calcium