title: Effect of nicardipine on the blood flow velocity in the vessel near a cerebral aneurysm of the internal carotid artery during cerebral aneurysm surgery: its therapeutic use for intra-operative hypertension.
abstract: Seven patients scheduled for clipping of an aneurysm of the internal carotid artery after subarachnoid haemorrhage, were studied in order to evaluate the efficacy of a bolus injection of nicardipine (2 mg) in the treatment of intra-operative hypertension on the blood flow velocity of vessel near the aneurysm under isoflurane anaesthesia. The blood flow velocity of the vessel near the aneurysm was measured using a 20 MHz ultrasound Doppler flowmeter. Nicardipine bolus significantly decreased the mean arterial blood pressure by about 30% (P < 0.01). The blood flow velocity of the internal carotid artery increased after the nicardipine bolus (from 43.3 +/- 9.9 to 51.7 +/- 15.0 cm s-1) (P < 0.05) but returned to the pre-injection level within 30 min (43.9 +/- 10.4 cm s-1). Nicardipine proved effective for control of intra-operative hypertension during aneurysm clipping.
authors.affiliation: Department of Anaesthesia, Osaka Police Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Inagaki
authors.forename: H
authors.initials: H
authors.lastname: Iwanaga
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply; D002340:Carotid Artery Diseases / Q000503:physiopathology / Q000601:surgery*; D002343:Carotid Artery, Internal; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D002532:Intracranial Aneurysm / Q000503:physiopathology / Q000601:surgery*; D007432:Intraoperative Period; D009529:Nicardipine / Q000627:therapeutic use*
chemical_list: D009529:Nicardipine