[The inhibition of the development of experimental tumors of the cervix uteri and vagina by using tinctures of the cultured-cell biomass of the ginseng root and its germanium-selective stocks].
The anticarcinogenic effects of bioginseng and two germanium-selective drugs produced by cultivating cells of ginseng radix (Panax ginseng C. A. Mey) in a conventional medium or in media containing organogermanium compounds were studied. Squamous-cell carcinomas of the uterus cervix and vagina were induced by intravaginal applications of 7,12-dimethylbenz(a)anthracene in mice. The drugs of ginseng were used orally or intravaginally during a long period of time of the postinitiation stage of carcinogenesis. All the drugs used locally effectively inhibited the development of induced carcinomas of the uterus cervix and vagina. When orally used, the drugs of ginseng exhibited only an insignificant tendency to inhibit the carcinogenesis of uterus cervix and vagina. The anticarcinogenic effects of the compared drugs were similar.
Bespalov
V G
VG
Davydov
V V
VV
Limarenko
A Iu
AIu
Slepian
L I
LI
Aleksandrov
V A
VA
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005857:Germanium / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000494:pharmacology; D005894:Panax / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage; D010946:Plants, Medicinal; D011230:Precancerous Conditions / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D009942:Organometallic Compounds; D010936:Plant Extracts; D005857:Germanium; D015127:9,10-Dimethyl-1,2-benzanthracene
Tormozhenie razvitiia éksperimental'nykh opukholeĭ sheĭki matki i vlagalishcha s pomoshch'iu nastoek biomassy kul'tiviruemykh kletok kornia zhen'shenia i ego germaniĭ-selektivnykh shtammov.