Detection of active form of transforming growth factor-beta in cerebrospinal fluid of patients with glioma.
We examined transforming growth factor-beta (TGF-beta) activity in cerebrospinal fluid of 39 patients with various brain tumors, and found it in 10 glioma cases that had lesions related to subarachnoid space or ventricle. In one glioma case, TGF-beta detected on admission disappeared after radiation and chemotherapy. We confirmed that five glioma cell lines produced TGF-beta, and that four of them produced active form of TGF-beta directly. The active form of TGF-beta was also identified from cerebrospinal fluid before the acidification treatment in two cases. The calculated contents were 110 ng/ml and 18 ng/ml. These results indicate that active form of TGF-beta is directly produced by tumor cells in patients with glioma, and may contribute to immunodeficiency of the host.
Tada
T
T
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto.
Yabu
K
K
Kobayashi
S
S
D001932:Brain Neoplasms / Q000134:cerebrospinal fluid*; D005910:Glioma / Q000134:cerebrospinal fluid*; D006801:Humans; D016212:Transforming Growth Factor beta / Q000134:cerebrospinal fluid*; D014407:Tumor Cells, Cultured
D016212:Transforming Growth Factor beta