title: [A case of suspected liver dysfunction induced by sevoflurane anesthesia].
abstract: We report a case of suspected liver dysfunction after general anesthesia with sevoflurane. A 30 day old male infant underwent inguinal herniorrhaphy under sevoflurane anesthesia (sevoflurane concentration: 1.3-1.5% with 50% oxygen and nitrous oxide). Two days after the operation, he developed frequent vomiting, anorexia and fever. GOT, GPT and LDH values were 242 Ku, 326 Ku and 901 Wu, respectively and peaked at 520 Ku, 709 Ku and 1000 Wu 12-16 days after the operation. Clinical symptoms and the laboratory data became normal within 2 months. The antibody titers of EB-virus, cytomegalo-virus and HA-virus were all within normal ranges and HBs antigen was negative. There were no blood transfusion or antibiotics administration before the onset, and no epidemic of hepatitis around him. His mother had no history of hepatitis during her pregnancy. Lymphocyte stimulation test for indication of sevoflurane allergy was also negative. From these evidences, toxic (not allergic) liver dysfunction due to exposure to sevoflurane was considered to be the most probable diagnosis.
authors.affiliation: Department of Anesthesiology, Ehime Prefecture Imabari Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Hatakenaka
authors.forename: K
authors.initials: K
authors.lastname: Ikemune
authors.forename: Y
authors.initials: Y
authors.lastname: Chigyo
authors.forename: T
authors.initials: T
authors.lastname: Kubozono
authors.forename: T
authors.initials: T
authors.lastname: Arai
mesh_terms: D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D004987:Ethers / Q000009:adverse effects*; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008738:Methyl Ethers; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane