title: Involvement of protein kinase C in proliferative response of osteoblastic cell lines stimulated with prostaglandin E2.
abstract: The proliferative action of prostaglandin E2 in a rat osteoblastic cell line was studied. Prostaglandin E2 has a crucial effect on bone remodeling process and is shown to stimulate protein and DNA synthesis in serum depleted condition. This reaction is completely inhibited by protein kinase C inhibitors, suggesting that protein kinase C activation induced by prostaglandin E2 is involved in the proliferative response of osteoblast cells.
authors.affiliation: Department of Oral Surgery, School of Medicine, Chiba University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miya
authors.forename: M
authors.initials: M
authors.lastname: Tagawa
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Fujimura
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D015232:Dinoprostone / Q000494:pharmacology*; D004789:Enzyme Activation; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats
chemical_list: D004247:DNA; D011493:Protein Kinase C; D015232:Dinoprostone