title: Perfluorocarbon effects on rabbit blood-retinal barrier permeability.
abstract: Studies have been made of the effects of intravitreal perfluoro-n-octane on the permeability to fluorescein of the blood-retinal barrier in rabbits. At day 1 after injection, there is increased aqueous humor fluorescence that reflects the physical disturbance to the eye following injection. From that time through 7 weeks, there is no evidence of any overt toxicity to the blood-retinal barrier. The retention in the vitreous of a small volume of perfluoro-n-octane following its intraoperative use would not be expected to induce a toxic response. Some effect on an already compromised retina cannot, however, be excluded.
authors.affiliation: Department of Ophthalmology Medical College of Georgia, Augusta 30912-3400.
authors.forename: K
authors.initials: K
authors.lastname: Green
authors.forename: T
authors.initials: T
authors.lastname: Slagle
authors.forename: M J
authors.initials: MJ
authors.lastname: Chaknis
authors.forename: L
authors.initials: L
authors.lastname: Cheeks
authors.forename: S
authors.initials: S
authors.lastname: Chang
mesh_terms: D000818:Animals; D001692:Biological Transport; D001813:Blood-Retinal Barrier; D002463:Cell Membrane Permeability; D019793:Fluorescein; D005452:Fluoresceins / Q000493:pharmacokinetics; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D015590:Fluorophotometry; D011817:Rabbits; D014822:Vitreous Body
chemical_list: D005452:Fluoresceins; D005466:Fluorocarbons; C073608:perfluorooctane; D019793:Fluorescein