Fatal hyperthyroidism after amiodarone treatment and total lymphoid irradiation in a heart transplant recipient.
Recurrent severe allograft rejection is an uncommon but difficult management problem in heart transplantation. Total lymphoid irradiation is now a recognized treatment modality when conventional therapy has failed. We describe an unusual complication of total lymphoid irradiation in a patient who had been treated with amiodarone for malignant arrhythmias before transplantation.
Hauptman
P J
PJ
Department of Cardiology, Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, N.Y. 10029-6574.
Fyfe
B
B
Mechanick
J
J
Lansman
S
S
Gass
A
A
D000638:Amiodarone / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D006084:Graft Rejection / Q000532:radiotherapy; D016027:Heart Transplantation; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D015182:Lymphatic Irradiation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000473:pathology
D000638:Amiodarone