title: A comparative study of the effect of atrial natriuretic peptide (ANP) on the secretory activity of rat adrenal cortex and angiotensin-II-responsive adrenocortical autotransplants.
abstract: Rat adrenocortical autotransplants regenerated from capsular-tissue fragments implanted in the musculus gracilis displayed an in-vitro basal gluco- and mineralocorticoid secretion qualitatively similar to that of adrenal quarters from control rats. Moreover, like adrenal quarters, they responded to angiotensin-II (Ang-II, 10(-8) M) by raising their yield of 18-hydroxylated steroids (18-hydroxy-11-deoxycorticosterone, 18-hydroxycorticosterone and aldosterone). ANP (10(-8) M), one of the main negative modulators of the zona-glomerulosa (ZG) mineralocorticoid secretion, totally blocked the ANG-II stimulating effect on adrenal quarters, but not that on adrenocortical autotransplants. Autoradiography showed that, in contrast with ZG cells of control rats, ZG-like cells of transplants did not significantly bind 125I-ANP. The hypothesis is discussed that ZG-like cells of regenerated adrenocortical nodules lack specific receptors for ANP.
authors.affiliation: Department of Anatomy, University of Padua, Italy.
authors.forename: A S
authors.initials: AS
authors.lastname: Belloni
authors.forename: G
authors.initials: G
authors.lastname: Neri
authors.forename: P G
authors.initials: PG
authors.lastname: Andreis
authors.forename: F G
authors.initials: FG
authors.lastname: Musajo
authors.forename: G
authors.initials: G
authors.lastname: Gottardo
authors.forename: G
authors.initials: G
authors.lastname: Mazzocchi
authors.forename: G G
authors.initials: GG
authors.lastname: Nussdorfer
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D008297:Male; D008901:Mineralocorticoids / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012636:Secretory Rate / Q000187:drug effects; D014182:Transplantation, Autologous; D015384:Zona Glomerulosa / Q000187:drug effects* / Q000378:metabolism / Q000637:transplantation
chemical_list: D008901:Mineralocorticoids; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor