Effect of preservative on the efficacy of terbutaline nebuliser solution in atopic asthma.
The efficacy of bronchodilator nebuliser solutions may be influenced by the presence of preservatives. In a double blind, randomised, crossover study the effect of preservatives in determining the airway responses to 5 mg of terbutaline was studied in a group of 21 atopic asthmatic patients. The presence of preservatives affected neither the bronchodilator action of terbutaline nor its protection against bronchoconstriction induced by histamine.
Lai
C K
CK
Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT.
Chan
C H
CH
D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D016084:Bronchoconstriction / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006632:Histamine; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D013726:Terbutaline / Q000008:administration & dosage*
D011310:Preservatives, Pharmaceutical; D006632:Histamine; D013726:Terbutaline