[The anti-ischemic properties of crown ether derivatives].
Experiments on open-chest anaesthetized cats were made to test derivatives of crown ethers, such as benzylase-15-crown-5 and dibenzylase-15-crown-5 for their effects on myocardial ischemia and the functional status of a myocardial ischemic focus in temporary coronary occlusion during coronary spasm induced by dihydroergotamine and during coronary microthrombosis caused by ADP. When intravenously administered in doses of 0.5-15 mg/kg, the tested agents were found to enhance myocardial tolerance to ischemia, depressed ST segment in ischemia induced by coronary occlusion and administration of ATP, and prevented ST-segment depression during coronary spasm.
Gurbanov
K G
KG
Paperno
A A
AA
Luk'ianenko
N G
NG
Basok
S S
SS
D000818:Animals; D002415:Cats; D043844:Crown Ethers; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004361:Drug Tolerance; D004562:Electrocardiography / Q000187:drug effects; D004988:Ethers, Cyclic / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology
D043844:Crown Ethers; D004988:Ethers, Cyclic; C058863:benzylaza-15-crown-5
Protivoishemicheskie svoĭstva proizvodnykh kraun-éfirov.