Glycine reduces early renal parenchymal uptake of cisplatin.
We evaluated the effect of glycine infusions on the early renal uptake of cisplatin, measured one hour after cisplatin was injected, as well as five days following cisplatin administration. Glycine (1.25 mmol per 100 g body wt) markedly attenuated the early uptake of platinum by the kidney, an effect not observed with control infusions of saline or of L-alanine. The kidney content of platinum at five days, on the other hand, was similar in glycine-treated animals and saline controls. Early inhibition of renal uptake of platinum may be responsible for glycine's protective action in experimental cisplatin nephrotoxicity.
Heyman
S N
SN
Charles A. Dana Research Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Spokes
K
K
Egorin
M J
MJ
Epstein
F H
FH
D000818:Animals; D002945:Cisplatin / Q000493:pharmacokinetics* / Q000633:toxicity; D005998:Glycine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010984:Platinum / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D010984:Platinum; D002945:Cisplatin; D005998:Glycine