[Cardiac contractile function following acute cooling of the body and the adaptogenic correction of its disorders].
In experiments on white Wistar rats the effect of acute 4-hour freezing at -10 degrees C on contractile function of the hearts isolated by the Langendorff technique, and the protective efficacy of Rhodiola rosea extract were investigated. The obtained results testify to the fact that acute cooling leads to a decrease in myocardial contractile activity that recovers during 18 hours. But this recovery cannot be complete as it does not result in stable contractility of isolated heart in perfusion. Preliminary adaptation of animals during treatment with Rhodiola rosea extract prevents the decrease in contractility force immediately after acute cooling and contributes to the stable contractility during 60 minutes of perfusion. Moreover, Rhodiola rosea extract does not remove the disturbance in diastolic function and in all cases leads to a decrease in coronary blood flow. The effect of Rhodiola rosea extract on the myocardium is likely to be similar to that of myocardial recovery after acute cooling.
Afanas'ev
S A
SA
Alekseeva
E D
ED
Bardamova
I B
IB
Maslova
L V
LV
Lishmanov
Iu B
IuB
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D010936:Plant Extracts
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