New electron microscopic findings in a case of multicentric reticulohistiocytosis. Long spacing collagen inclusions.
The case of a 68-year-old woman with polyarthropathy and skin nodules is presented. Histologic findings of histiocytes with ground-glass cytoplasm favored the diagnosis of multicentric reticulohistiocytosis. In this article we report new electron microscopic findings of intra- and extracytoplasmic long spacing collagen (type VI). Type VI collagen inclusions are usually found in lymphohistiocytic neoplasms. We believe our findings support the concept of a proliferative rather than inflammatory etiology for multicentric reticulohistiocytosis. It may also give support for the argument of production of collagen by the histiocytic cells of multicentric reticulohistiocytosis.
Fortier-Beaulieu
M
M
Clinique dermatologique, Centre Hospitalier et Universitaire de Rouen, France.
Thomine
E
E
Boullie
M C
MC
Le Loët
X
X
Lauret
P
P
Hemet
J
J
D000368:Aged; D003094:Collagen / Q000648:ultrastructure*; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006801:Humans; D012867:Skin / Q000648:ultrastructure*; D012871:Skin Diseases / Q000473:pathology*
D003094:Collagen