Age-related digoxin-alprazolam interaction.
A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpatients receiving long-term digoxin (0.25 mg daily) randomly received oral administration of either 1.0 or 0.5 mg alprazolam per day for 7 days. In each dosage group, three patients were older than and three were younger than 65 years of age. The area under the concentration-time curve for serum digoxin increased significantly in patients receiving 1 mg alprazolam daily, and this increase was more pronounced in patients older than 65 years of age. Clinical digoxin toxicity developed in one elderly patient who was receiving 1 mg/day alprazolam.
Guven
H
H
Department of Pharmacology, Dokuz Eylul University Hospital, Inciralti, Izmir, Turkey.
Tuncok
Y
Y
Guneri
S
S
Cavdar
C
C
Fowler
J
J
D000368:Aged; D000375:Aging / Q000378:metabolism*; D000525:Alprazolam / Q000494:pharmacology*; D004077:Digoxin / Q000097:blood / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008875:Middle Aged
D004077:Digoxin; D000525:Alprazolam