title: Carbamazepine coadministration with fluoxetine or fluvoxamine.
abstract: To study the potential interaction between carbamazepine (CBZ) and selective serotonin reuptake inhibitors, fluoxetine (20 mg/day) and fluvoxamine (100 mg/day) were administered for 3 weeks to eight and seven epileptic patients, respectively, on chronic CBZ treatment. No significant changes in steady-state plasma concentrations of CBZ and its active metabolite, carbamazepine-10,11-epoxide (CBZ-E) occurred, suggesting that CBZ metabolism is probably not affected by fluoxetine or fluvoxamine administration.
authors.affiliation: Institute of Pharmacology, University of Messina, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Spina
authors.forename: A
authors.initials: A
authors.lastname: Avenoso
authors.forename: A M
authors.initials: AM
authors.lastname: Pollicino
authors.forename: A P
authors.initials: AP
authors.lastname: Caputi
authors.forename: A
authors.initials: A
authors.lastname: Fazio
authors.forename: F
authors.initials: F
authors.lastname: Pisani
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use*; D003863:Depression / Q000097:blood / Q000150:complications / Q000188:drug therapy; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D017029:Epilepsy, Complex Partial / Q000097:blood / Q000150:complications / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000097:blood / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D016666:Fluvoxamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005473:Fluoxetine; D002220:Carbamazepine; D016666:Fluvoxamine; C012227:carbamazepine epoxide