title: Adjuvant oestrogen therapy does not improve disease activity in postmenopausal patients with rheumatoid arthritis.
abstract: OBJECTIVE
  To investigate whether oestrogens can be used as treatment to diminish disease activity in women with rheumatoid arthritis.
  
  
  METHODS
  Forty postmenopausal female patients with active rheumatoid arthritis participated in a placebo-controlled, double-blind study on the possible beneficial effect of adjuvant treatment of oestradiol on disease activity.
  
  
  RESULTS
  Thirty three patients completed 52 weeks of treatment with 2 mg oestradiol-valerate or placebo. No statistically significant difference was found in and between both treatment groups with regard to articular indices, pain score by visual analogue scale, erythrocyte sedimentation rate and health questionnaire on daily activities before, during and at the end of the study.
  
  
  CONCLUSIONS
  This first randomised prospective placebo-controlled study shows no beneficial effect of oestrogens on disease activity in postmenopausal female patients with rheumatoid arthritis.
authors.affiliation: Department of Rheumatology, University Hospital Utrecht, The Netherlands.
authors.forename: H R
authors.initials: HR
authors.lastname: van den Brink
authors.forename: A A
authors.initials: AA
authors.lastname: van Everdingen
authors.forename: M J
authors.initials: MJ
authors.lastname: van Wijk
authors.forename: J W
authors.initials: JW
authors.lastname: Jacobs
authors.forename: J W
authors.initials: JW
authors.lastname: Bijlsma
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D001799:Blood Sedimentation; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D010352:Patient Dropouts; D017698:Postmenopause; D012720:Severity of Illness Index
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004958:Estradiol