title: [Daily single-dose aminoglycoside administration. Therapeutic and economic benefits].
abstract: Aminoglycosides are among the most active antimicrobial agents against Gram-negative infections, but they also share the potential for oto- and nephrotoxicity. Animal studies have shown that dosing aminoglycosides once daily is more efficient and less nephrotoxic than the conventional multiple daily dosing regimens. Pharmacokinetic and microbiological data support this finding. Clinical trials confirm that once-daily dosing is more efficient and less toxic than multiple daily dosing. The two most important risk factors for nephrotoxicity seem to be the duration of aminoglycoside treatment and high trough levels of aminoglycoside. Netilmicin and amikacin are the drugs most often used in clinical trials of once-daily dosing regimens. Recommendations for once-daily dosing of netilmicin are given.
authors.affiliation: Medicinsk-haematologisk afdeling L, Københavns Amts Sygehus i Herlev.
authors.forename: L M
authors.initials: LM
authors.lastname: Knudsen
authors.forename: N
authors.initials: N
authors.lastname: Frimodt-Møller
authors.forename: M T
authors.initials: MT
authors.lastname: Hansen
authors.forename: E
authors.initials: E
authors.lastname: Hippe
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D003718:Denmark; D007758:Ear, Inner / Q000187:drug effects; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents
vernacular_title: Aminoglykosidadministration én gang i døgnet. En terapeutisk og øokonomisk gevinst.