[The realization of the antiestrogen effect of tamoxifen in endometrial adenomatosis in women of reproductive age].
Patients of a reproductive age suffering from relapsing hyperplastic processes and adenomatosis of the endometrium were treated with tamoxifen, an antiestrogen. Time course of sex steroid hormones, steroid-binding globulin, and estrogen receptors in endometrial tissue was monitored over the course of therapy. A three-month course resulted in adenomatosis disappearance in more than 90% of patients. Tamoxifen antiestrogenic effect is realized both at the expense of blocking endometrial estrogen receptors which is indicated by their reduced number and by enhanced binding of sex hormone free fractions at the expense of increased synthesis of steroid-binding globulin under the effect of tamoxifen.
Putyrskaia
N P
NP
Chernukha
G E
GE
D000236:Adenoma / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D003600:Cytosol / Q000737:chemistry / Q000187:drug effects; D004341:Drug Evaluation; D004714:Endometrial Hyperplasia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis / Q000187:drug effects; D013629:Tamoxifen / Q000627:therapeutic use*; D013997:Time Factors
D011960:Receptors, Estrogen; D013629:Tamoxifen
Realizatsiia antiéstrogennogo éffekta tamoksifena pri adenomatoze éndometriia u zhenshchin reproduktivnogo vozrasta.