title: Chronic iron intake and diarrhoeal disease in infants. A field study in a less-developed country.
abstract: The effect of chronic iron intake on diarrhoeal disease was evaluated in children in a community of low socio-economic stratum in Santiago, Chile. Children were incorporated into each of two consecutive cohorts; each cohort was divided into two groups, one receiving iron-enriched milk (12 mg/l) (monthly average = 70 children) and the other a control milk (1 mg/l) (monthly average = 83 children), and each cohort was followed up for 6 months. The incidence of diarrhoea was higher among the iron-supplemented children (30.4 vs 25.5 episodes/100 children/month, P < 0.025). This was mainly due to results obtained in infants 3-8 months of age during the summer months. Supplemented infants had more bowel movements on day 1 (P < 0.03) and liquid or semi-liquid stools were passed for more than 15 days more frequently (P < 0.05). While no differences were detected in aetiology, Shigella-associated episodes were less common among iron-supplemented infants (P < 0.008). Asymptomatic shedding of enteropathogens significantly increased in infants 12-18 months of age receiving iron-supplemented milk. In areas with inadequate environmental sanitation, chronic iron supplementation may have negative effects on diarrhoeal morbidity, despite improving iron nutritional status.
authors.affiliation: Gastroenterology Unit, University of Chile, Santiago.
authors.forename: O
authors.initials: O
authors.lastname: Brunser
authors.forename: J
authors.initials: J
authors.lastname: Espinoza
authors.forename: M
authors.initials: M
authors.lastname: Araya
authors.forename: I
authors.initials: I
authors.lastname: Pacheco
authors.forename: S
authors.initials: S
authors.lastname: Cruchet
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002677:Chile / Q000453:epidemiology; D003906:Developing Countries; D003968:Diarrhea, Infantile / Q000139:chemically induced / Q000453:epidemiology* / Q000382:microbiology; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D005527:Food, Fortified / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007223:Infant; D008892:Milk; D012621:Seasons; D012959:Socioeconomic Factors
chemical_list: D005296:Ferrous Compounds; C020748:ferrous sulfate