Invasive aspergillosis in leukemic children.
Two cases of invasive aspergillosis are reported. Case 1, a 3-year-old boy with leukemic transformation of myelodysplastic syndrome, had an aspergillus infection in the hand, resulting in necrosis of the thumb. Case 2, an 18-year-old girl with acute megakaryoblastic leukemia, had an aspergillus skin infection on the wrist, accompanied by swelling and discoloration of the arm. In Case 2, angiography revealed a hypovascular lesion and vascular irregularity, suggesting that vessels were involved. Intraarterial infusion of urokinase and amphotericin B led to improvement of these symptoms in this patient. The combination of urokinase and an antifungal drug should be considered for intractable aspergillus infections involving the extremities.
Shitara
T
T
Department of Pediatrics, Gunma University School of Medicine, Japan.
Yugami
S
S
Sotomatu
M
M
Oshima
Y
Y
Ijima
H
H
Kuroume
T
T
Matsumoto
M
M
D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology*; D002675:Child, Preschool; D003881:Dermatomycoses / Q000209:etiology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications*; D008297:Male; D013927:Thrombosis / Q000209:etiology / Q000628:therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D000666:Amphotericin B; D014568:Urokinase-Type Plasminogen Activator