Alanine aminotransferase levels in Hispanics.
To prevent posttransfusion viral hepatitis, screening of potential blood donors includes the measurement of serum alanine aminotransferase (ALT) levels. The current use of single system-wide ALT cutoffs to determine acceptability of a blood unit or donor may not be appropriate, since male and Hispanic blood donors have much higher rejection rates than other donors, based solely on ALT level. Serum ALT measurements from the Hispanic Health and Nutrition Examination Survey were used to confirm these ALT elevations within general population samples of Mexican Americans, Cubans, and Puerto Ricans. Until specific tests are available to detect all hepatitis viral infections, testing blood donors for ALT levels will likely continue. Health personnel should be cautious in their interpretation of "elevated" ALT levels in these Hispanic populations.
Carter-Pokras
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OD
Office of Minority Health, Office of the Assistant Secretary for Health, Rockville, Maryland 20852.
Najjar
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MF
Billhymer
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BF
Shulman
I A
IA
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001782:Blood Donors; D003462:Cuba / Q000208:ethnology; D006525:Hepatitis, Viral, Human / Q000517:prevention & control; D006630:Hispanic or Latino; D006801:Humans; D017058:Mexican Americans; D008875:Middle Aged; D011647:Puerto Rico / Q000208:ethnology; D014481:United States
D000410:Alanine Transaminase