[Hematological changes associated with human immunodeficiency virus (HIV-1) infection].
Infection with human immunodeficiency virus type 1 (HIV-1) primarily involves a subgroup of T-lymphocytic cells, but other cell types are also invaded by the virus, including cell lines within the haematopoietic system. Together with infectious, inflammatory and neoplasic processes, invasion of haematopoietic tissue explains the haematological alterations which are seen during the course of infection with HIV-1. Anaemia develops in the large proportion of patients. Thrombocytopenia frequently occurs during the course of the disease, but may be seen in some patients already at the time of diagnosis, where the condition may be misdiagnosed as "idiopathic" thrombocytopenic purpura. Neutropenia is seen in all disease stages, but is most severe in patients with advanced disease. Bone marrow changes include varying degrees of dysplasia in one or more cell lines, which in some patients may mimic a myelodysplastic syndrome. The number of plasma cells is always increased. In many patients the bone marrow stroma exhibits an increased amount of reticular fibres. HIV-1 infection is associated with an increased risk of non-Hodgkin malignant lymphoma. Acute myelogenous leukaemia and myelomatosis have been described in patients with advanced disease. Treatment of the above mentioned haematological abnormalities aims primarily at reducing replication of HIV-1, thereby diminishing suppression of haematopoiesis by the virus infection, and at controlling the opportunistic infections during the course of the disease. Specific antiviral therapy (AZT) is most successful in correcting thrombocytopenia. The possibility of bone marrow suppression mediated by a toxic drug effect should always be considered in this patient group.
Møller
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Epidemiafdeling M, Rigshospitalet, København.
Hasselbalch
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HC
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000150:complications / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000473:pathology; D015497:HIV-1; D006402:Hematologic Diseases / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D008297:Male
Haematologiske forandringer ved infektion med human immundefekt virus (HIV-1).