title: Cytogenetics of Askin's tumour. Case report and review of the literature.
abstract: The eleventh cytogenetically analyzed Askin's tumour, diagnosed in a two-year-old girl, is reported. Chromosomal analysis revealed a pseudodiploid karyotype of tumour cells with translocations of t(11;22)(q24;q12) and der(4)t(2;4)(q24;q35). The observed t(11;22)(q24;q12) is not only a unique characteristic of all cytogenetically analyzed Askin's tumours but it also occurs in 92-100% of peripheral neuroepithelioma and of Ewing's sarcoma, irrespective of its osseous or extraosseous localization. This genetical similarity further supports a nosological concept according to which Askin's tumour, Ewing's sarcoma and peripheral neuroepithelioma represent phenotypic variations of the same tumour, namely the peripheral primitive neuroectodermal tumour.
authors.affiliation: Department of Pathology, Medical Faculty, Technical University of Aachen, FRG.
authors.forename: L
authors.initials: L
authors.lastname: Füzesi
authors.forename: R
authors.initials: R
authors.lastname: Heller
authors.forename: H
authors.initials: H
authors.lastname: Schreiber
authors.forename: R
authors.initials: R
authors.lastname: Mertens
mesh_terms: D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000648:ultrastructure; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis; D012512:Sarcoma, Ewing / Q000175:diagnosis; D013899:Thoracic Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000648:ultrastructure