Strength and endurance characteristics of the normal human genioglossus.
Since activity of the genioglossus muscle plays a primary role in maintaining upper airway patency during sleep, its strength and endurance characteristics are of potential importance. The purpose of this study was 2-fold. First, to define the strength and endurance characteristics of the normal human genioglossus. Second, we hypothesized that because the genioglossus has a high proportion of fast glycolytic muscle fibers, brief periods of increased activity would make it more susceptible to fatigue. In five normal male subjects strength of the tongue was evaluated by measuring maximal anterior force using a transducer (Fmax). In each subject tongue endurance was then tested at 100%, 80%, and 50% Fmax. To test the effect of a short-term increase in genioglossal activity on its endurance, an inspiratory flow-resistive load with mild hypercapnia was presented to the upper airway for 10 min, after which genioglossal endurance at 80% Fmax was repeated. On a separate day the effect of inspiratory loading plus hypercapnia on thoracic inspiratory muscle endurance was also tested. Our results showed that mean Fmax was 1,267 +/- 125 (SEM) g. Endurance time (Tlim) decreased progressively during 50%, 80% and 100% Fmax trials. Short-term activation of the genioglossus caused a reduction in Tlim at 80% Fmax to 51.4 +/- 4.8% of its value before loading (p < 0.05). Tlim for the inspiratory muscles, however, was unaffected. We conclude that, like other skeletal muscles, genioglossal endurance is reduced as the force of contraction increases. In addition, genioglossal endurance is significantly reduced by short-term activation insufficient to fatigue the thoracic inspiratory muscles.
Scardella
A T
AT
Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903-0019.
Krawciw
N
N
Petrozzino
J J
JJ
Co
M A
MA
Santiago
T V
TV
Edelman
N H
NH
D000328:Adult; D004576:Electromyography / Q000379:methods; D005221:Fatigue / Q000503:physiopathology; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology*; D010807:Physical Endurance; D012016:Reference Values; D012119:Respiration; D013997:Time Factors; D014059:Tongue / Q000502:physiology*; D014160:Transducers, Pressure