title: [Positive and negative controls on hematopoietic progenitor development: models and facts].
abstract: The stochastic model of stem cell differentiation is in accord with experimental findings but does not explain hematopoietic homeostasis. We discuss how positive and negative controls by cytokines and inhibitors could maintain homeostasis, even though progenitor commitment towards the various hematopoietic lineages may be stochastic.
authors.affiliation: Laboratoire CNRS de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, UPR 272, IRSC, Villejuif, France.
authors.forename: B
authors.initials: B
authors.lastname: Panterne
authors.forename: A
authors.initials: A
authors.lastname: Hatzfeld
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zhou
authors.forename: M L
authors.initials: ML
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Sansilvestri
authors.forename: A
authors.initials: A
authors.lastname: Cardoso
authors.forename: J P
authors.initials: JP
authors.lastname: Lévesque
authors.forename: M
authors.initials: M
authors.lastname: Ginsbourg
authors.forename: P
authors.initials: P
authors.lastname: Batard
authors.forename: S
authors.initials: S
authors.lastname: Kiselev
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D003115:Colony-Stimulating Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D013269:Stochastic Processes
chemical_list: D003115:Colony-Stimulating Factors
vernacular_title: Contrôles positifs et négatifs du développement des progéniteurs hématopoïétiques: modèles et faits.