title: An open-trial evaluation of mitoxantrone in the treatment of progressive MS.
abstract: We treated 13 patients with progressive MS with mitoxantrone. All patients received a standard IV dose of mitoxantrone (8 mg/m2) every 3 weeks for a total of seven infusions, with dosage adjustments depending on the hematologic profile at the nadir. The treatment was well tolerated, with the most common side effect being mild nausea. Four of seven women developed transient secondary amenorrhea. The postenrollment clinical behavior of these patients was generally more favorable than during the 18 months prior to enrollment (only three of 13 patients developed an increase in the Expanded Disability Status Scale of more than 0.5 points), suggesting a possible treatment effect, but comparison with two historical control groups (both the active and placebo groups from the Canadian Cooperative Trial of Cyclophosphamide and Plasma Exchange) does not suggest that mitoxantrone was efficacious. Eight of 12 patients had evidence of MRI activity on 13 of 29 follow-up visits. This small, open-labeled pilot study did not provide strong support for proceeding with a randomized, controlled trial of this dosage regimen of mitoxantrone in patients with progressive MS.
authors.affiliation: Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
authors.forename: J H
authors.initials: JH
authors.lastname: Noseworthy
authors.forename: M B
authors.initials: MB
authors.lastname: Hopkins
authors.forename: M K
authors.initials: MK
authors.lastname: Vandervoort
authors.forename: S J
authors.initials: SJ
authors.lastname: Karlik
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Penman
authors.forename: G P
authors.initials: GP
authors.lastname: Rice
authors.forename: K D
authors.initials: KD
authors.lastname: Grinwich
authors.forename: H
authors.initials: H
authors.lastname: Cauvier
authors.forename: B J
authors.initials: BJ
authors.lastname: Harris
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D010865:Pilot Projects
chemical_list: D008942:Mitoxantrone