title: Race and sex differences in associations of vegetables, fruits, and carotenoids with lung cancer risk in New Jersey (United States).
abstract: We used data from a case-control study conducted in New Jersey between 1980 and 1983 to evaluate race and sex differences in associations of vegetable, fruit, and carotenoid consumption with lung cancer. Cases included 736 White males, 860 White females, 269 Black males, and 86 Black females with incident, histologically confirmed, primary cancer of the trachea, bronchus, or lung. Controls were identified through drivers' license and Health Care Financing Administration files and included 548 White males, 473 White females, 170 Black males, and 47 Black females. Usual intakes of vegetables (predominantly yellow/green) and fruit (predominantly yellow/orange) as well as other food sources of carotenoids were ascertained by a food frequency questionnaire. White females showed significant inverse associations of lung cancer with vegetables, fruit, and carotenoids. White males showed nonsignificant inverse associations with vegetables and carotenoids, and Black females just with vegetables. No inverse associations were found for Black males. Vegetable consumption was associated with risk of all histologic types of lung cancer, but the pattern of increasing risk with decreasing intake was limited to smokers. We infer that consumption of yellow/green vegetables and carotenoids may confer protection from lung cancer to White male and White female smokers. Further studies are needed to clarify the effect in Blacks.
authors.affiliation: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892.
authors.forename: J F
authors.initials: JF
authors.lastname: Dorgan
authors.forename: R G
authors.initials: RG
authors.lastname: Ziegler
authors.forename: J B
authors.initials: JB
authors.lastname: Schoenberg
authors.forename: P
authors.initials: P
authors.lastname: Hartge
authors.forename: M J
authors.initials: MJ
authors.lastname: McAdams
authors.forename: R T
authors.initials: RT
authors.lastname: Falk
authors.forename: H B
authors.initials: HB
authors.lastname: Wilcox
authors.forename: G L
authors.initials: GL
authors.lastname: Shaw
mesh_terms: D001741:Black or African American; D000368:Aged; D002338:Carotenoids; D016022:Case-Control Studies; D004032:Diet; D004034:Diet Surveys; D005260:Female; D005638:Fruit; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009515:New Jersey / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D014675:Vegetables; D044465:White People
chemical_list: D002338:Carotenoids