[Clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis B].
This paper reports that 320 patients with chronic hepatitis B (CHB) were treated with Yi-ganning Granule (YGNG) and the pharmacodynamics of YGNG in the animal study. As control, another 70 patients with CHB receiving oleanolic acid granule (OAG) were compared to 68 patients in YGNG group. YGNG is consisted of Astragalus membranaceus , Artemisia capillaris, Codonopsis pilosula, et al. Each patient has taken YGNG or OAG for 3 months. The result showed YGNG was effective on recovering the liver function and OAG had similar effect. The sero-negative conversion rates of HBsAg, HBeAg, HBcAb and positive conversion rate of HBeAb in the YGNG group were 33.1%, 40.5%, 10.5% and 15.5% respectively, which were much better than that in OAG group (P < 0.05-0.001). The result of 6 months follow up showed that 60 of 62 patients receiving YGNG were in stabilized state. The result in the animal study demonstrated that YGNG had significant protection from the liver damage caused by CCl4. YGNG could decrease serum ALT level and protect the liver function of carbohydrate, fat, protein metabolism and detoxication. YGNG could induce interferon in vivo and play an important role in seroconversion of negative DHBV-DNA and improvement of pathological morphology in viral hepatitis B.
Zhang
B Z
BZ
Hunan Academy of TCM and Pharmacology, Changsha.
Ding
F
F
Tan
L W
LW
D000293:Adolescent; D000328:Adult; D000818:Animals; D027885:Astragalus propinquus; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004372:Ducks; D005260:Female; D018347:Hepadnaviridae Infections / Q000188:drug therapy; D006509:Hepatitis B / Q000188:drug therapy*; D015611:Hepatitis B Virus, Duck; D006521:Hepatitis, Chronic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal