title: Measuring male reproductive hormones for occupational field studies.
abstract: As part of our longitudinal study of unexposed workers, we drew blood samples and analyzed the individual endocrine profiles for 45 men. The blood collection was between 8 AM and 8 PM, and three blood samples were drawn 20 minutes apart on three occasions during the course of the study (June, October, and February). Serum concentrations of follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin were determined. A component of variance model was used to estimate variability between the 20-minute blood draws. Statistical power analysis using this component showed that three blood draws provide a marginal improvement over a single blood draw in detecting population shifts. Also, if the prospect of three blood draws reduces subject participation by 10 to 20%, the increase in power would be negated.
authors.affiliation: National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226-1998.
authors.forename: S M
authors.initials: SM
authors.lastname: Schrader
authors.forename: T W
authors.initials: TW
authors.lastname: Turner
authors.forename: M J
authors.initials: MJ
authors.lastname: Breitenstein
authors.forename: S D
authors.initials: SD
authors.lastname: Simon
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000097:blood*; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008838:Microcomputers; D009784:Occupational Diseases / Q000097:blood*; D016273:Occupational Exposure / Q000009:adverse effects*; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone