title: In vitro activity of ramoplanin against vancomycin-resistant gram-positive organisms.
abstract: In vitro activity of ramoplanin, a cyclic lipoglycopeptide, against 92 vancomycin-resistant gram-positive organisms was evaluated. Ramoplanin demonstrated potent activity against many highly vancomycin-resistant organisms including enterococci (MICs for 90% of strains tested of 0.5 micrograms/ml) and against Lactobacillus spp., Leuconostoc spp., and Pediococcus spp., all of which were inhibited at concentrations of < or = 0.25 micrograms/ml. This drug or a derivative compound merits further investigation as a potential therapeutic agent for infections due to vancomycin-resistant enterococci.
authors.affiliation: Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.
authors.forename: L A
authors.initials: LA
authors.lastname: Collins
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
authors.forename: C B
authors.initials: CB
authors.lastname: Wennersten
authors.forename: M J
authors.initials: MJ
authors.lastname: Ferraro
authors.forename: R C
authors.initials: RC
authors.lastname: Moellering
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D047630:Depsipeptides; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C041438:ramoplanin; D014640:Vancomycin