title: Expression of the c-erbB-3 gene product in gastric cancer.
abstract: The pattern of c-erbB-3 gene product was studied in 91 advanced gastric carcinomas, adjacent hyperplastic mucosa, intestinal metaplasia and dysplasia and in normal controls, using immunohistochemistry in archival material. All tumours showed positive c-erbB-3 staining in both cytoplasm and membrane. No significant differences of expression were observed between intestinal and diffuse-type carcinomas or any other clinical parameters. Of interest is the expression in the adjacent mucosa, which is extensive, cytoplasmic, and of lower intensity than in the tumours. Further studies are currently being carried out to clarify the role of this protein in tumour behaviour and gastric carcinogenesis.
authors.affiliation: Department of Histopathology, UMDS Guy's Hospital, London.
authors.forename: E E
authors.initials: EE
authors.lastname: Sanidas
authors.forename: M I
authors.initials: MI
authors.lastname: Filipe
authors.forename: J
authors.initials: J
authors.lastname: Linehan
authors.forename: N R
authors.initials: NR
authors.lastname: Lemoine
authors.forename: W J
authors.initials: WJ
authors.lastname: Gullick
authors.forename: T
authors.initials: T
authors.lastname: Rajkumar
authors.forename: D A
authors.initials: DA
authors.lastname: Levison
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002462:Cell Membrane / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D020893:Receptor, ErbB-3; D013274:Stomach Neoplasms / Q000737:chemistry*
chemical_list: D011518:Proto-Oncogene Proteins; D020893:Receptor, ErbB-3