[The effect of x-ray contrast media on the amount of thromboxane and prostacyclin in the blood of man and rats in vivo and in vitro].
The in vivo and in vitro effects of radioopaque agents such as bilignost, iodamide, and triombrast on blood thromboxane B2 (TxB2) and prostacyclin levels were studied in man and rats. These radioopaque agents were demonstrated to increase prostacyclin levels and to decrease TxB2 in the plasma by 40%, as evidenced by urography when given in vivo (1-2 g/kg) and in vitro (2.5.10(-2) M and 2.5.10(-3) M).
Napolov
Iu K
IuK
Shimanovskiĭ
N L
NL
Bolotova
E N
EN
Borsukova
N M
NM
Sergeev
P V
PV
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007451:Iodamide / Q000494:pharmacology; D007458:Iodipamide / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013928:Thromboxane A2 / Q000097:blood*; D013929:Thromboxane B2 / Q000097:blood*; D014567:Urography
D003287:Contrast Media; D003974:Diatrizoate Meglumine; D007451:Iodamide; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D007458:Iodipamide
Vliianie rentgenokontrastnykh sredstv na kolichestvo troboksana i prostatsiklina v krovi u cheloveka i krys in vivo i in vitro.