title: Influence of breast and formula feeding on hepatic concentrations of apolipoprotein and low-density lipoprotein receptor mRNAs.
abstract: We tested the hypothesis that breast and formula feeding differentially affect hepatic mRNA concentrations for LDL receptor (LDL-R) and apolipoproteins A-I, B and E in infant baboons during the preweaning period. The mRNA concentrations were measured in liver biopsies obtained prior to weaning at 14 weeks from 43 baboons that were either breast-fed (n = 17) or fed formulas with a high (n = 12) or low (n = 14) polyunsaturated/saturated (P:S) fat ratio. Breast-fed baboons had 99% higher LDL-R mRNA concentrations compared with infants fed formulas, but there were no differences among breast and formula-fed baboons in mRNA concentrations of apolipoproteins A-I, B or E. The fatty acid P:S ratio of the formulas did not affect hepatic LDL-R or apolipoprotein mRNA concentrations. These results suggest that breast-feeding increases LDL-R gene expression even though breast milk is higher in cholesterol and saturated fat compared with formulas.
authors.affiliation: Department of Pathology, University of Texas Health Science Center, San Antonio 78284.
authors.forename: G E
authors.initials: GE
authors.lastname: Mott
authors.forename: L
authors.initials: L
authors.lastname: DeLallo
authors.forename: D M
authors.initials: DM
authors.lastname: Driscoll
authors.forename: C A
authors.initials: CA
authors.lastname: McMahan
authors.forename: D S
authors.initials: DS
authors.lastname: Lewis
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001053:Apolipoproteins / Q000032:analysis* / Q000235:genetics; D001942:Breast Feeding; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D005526:Food, Formulated; D015870:Gene Expression; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D010215:Papio; D012333:RNA, Messenger / Q000032:analysis; D011973:Receptors, LDL / Q000032:analysis* / Q000235:genetics; D014886:Weaning
chemical_list: D001053:Apolipoproteins; D004041:Dietary Fats; D008074:Lipoproteins; D012333:RNA, Messenger; D011973:Receptors, LDL; C030104:lipoprotein cholesterol; D002784:Cholesterol