title: Rhabdomyosarcomas in young pigs in a swine breeding farm: a morphologic and immunohistochemical study.
abstract: Within a 6-month-period, solitary or multiple tumors were observed in 25 young pigs in their first weeks of life in a swine breeding farm. The herd comprised approximately 100 animals, and affected pigs were observed in several litters. The number of affected littermates varied from one to three. Five animals, all from different litters and with a total of 11 tumors, were studied. Histologically the tumors were classified as undifferentiated sarcomas. Electron microscopic examination of the tumors (n = 3) revealed myogenic differentiation, characterized by the presence of numerous cytoplasmic filaments with longitudinal densities and cytoplasmic dense bodies. Immunohistochemically, all 11 tumors were labeled by vimentin and desmin antibodies. Two tumors from which frozen material was available were additionally labeled by a titin antibody but did not show immunoreactivity with antibodies directed against myosin and alpha-sarcomeric actin. The tumors were finally diagnosed as undifferentiated rhabdomyosarcomas. The high incidence of these tumors within a short period of time in multiple young animals in different litters indicates a common causative event. The clinical history suggests a genetic cause.
authors.affiliation: Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Vos
authors.forename: G H
authors.initials: GH
authors.lastname: Borst
authors.forename: J
authors.initials: J
authors.lastname: Martin de las Mulas
authors.forename: F C
authors.initials: FC
authors.lastname: Ramaekers
authors.forename: F N
authors.initials: FN
authors.lastname: van Mil
authors.forename: R F
authors.initials: RF
authors.lastname: Molenbeek
authors.forename: D
authors.initials: D
authors.lastname: Ivanyi
authors.forename: T S
authors.initials: TS
authors.lastname: van den Ingh
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000032:analysis*; D004196:Disease Outbreaks; D008854:Microscopy, Electron; D012208:Rhabdomyosarcoma / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000473:pathology*
chemical_list: D003598:Cytoskeletal Proteins