Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice.
Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.
Fu
P P
PP
National Center for Toxicological Research, Jefferson, AR 72079.
Dooley
K L
KL
Von Tungeln
L S
LS
Bucci
T
T
Hart
R W
RW
Kadlubar
F F
FF
D000236:Adenoma / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics; D002911:Chrysenes / Q000493:pharmacokinetics; D004249:DNA Damage; D002149:Energy Intake; D005508:Food Deprivation; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice
D002273:Carcinogens; D002911:Chrysenes; C035986:6-nitrochrysene