Intravitreal flomoxef sodium in rabbits.
We studied the intraocular concentration of flomoxef sodium in nonvitrectomized and vitrectomized eyes of albino rabbits after intravenous administration of 100 mg/kg flomoxef sodium. The concentration of flomoxef sodium in the vitreous body was undetectable (< 0.1 micrograms/ml) in nonvitrectomized eyes. Retinal toxicity of flomoxef sodium was investigated with ophthalmoscopy, electroretinography (ERG) and light microscopy after intravitreal injection of 200, 500, 1,000 and 2,000 micrograms flomoxef sodium in albino and pigmented rabbits. No ERG changes were induced with 200 micrograms. Other higher doses caused transient ERG changes. After the 200-micrograms injection, the intravitreal concentration decreased exponentially, the half-life being 4.4 h. The antibacterial activity, broad coverage and low intravitreal toxicity of flomoxef sodium suggest that this compound may be used to treat bacterial endophthalmitis.
Mochizuki
K
K
Department of Ophthalmology, School of Medicine, Kanazawa University, Japan.
Torisaki
M
M
Yamashita
Y
Y
Komatsu
M
M
Tanahashi
T
T
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002511:Cephalosporins / Q000493:pharmacokinetics* / Q000633:toxicity; D004596:Electroretinography / Q000187:drug effects; D009877:Endophthalmitis / Q000188:drug therapy; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000473:pathology; D014822:Vitreous Body / Q000378:metabolism*
D002511:Cephalosporins; C045693:flomoxef