title: Systemic phaeohyphomycosis caused by Exophiala dermatitidis.
abstract: We report a case of systemic phaeohyphomycosis due to Exophiala dermatitidis in a 24-year-old man. At the age of 17, the patient had noticed cervical swellings. On palpation at his initial examination, more than a dozen firm lymph nodes between 1 and 5 cm in diameter were found on both sides of the neck and in both axillae. Examination of biopsy specimens of lymph nodes revealed pale brown hyphae in granulomatous lesions and Exophiala dermatitidis was isolated from mycological cultures of the local tissues. The clinical course was marked by an episode of jaundice six months later, and surgery disclosed a fist-sized inflammatory mass in the region of the head of the pancreas and the duodenum. The patient was treated by providing external biliary drainage and by the administration of antifungal agents, but two years later complained of diplopia and a slight heaviness in the head. Computed tomographic scans were made of the head, revealing multiple plum-sized masses in the brain. The patient died a year later. In Japan, 10 cases of systemic infection by this organism (including the present one) have been reported, all in patients of up to 30 years of age, with lesions appearing in the brain, lung, liver, digestive organs and lymph nodes. The prognosis is grave.
authors.affiliation: Department of Dermatology, National Defense Medical College, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hiruma
authors.forename: A
authors.initials: A
authors.lastname: Kawada
authors.forename: H
authors.initials: H
authors.lastname: Ohata
authors.forename: Y
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: A
authors.initials: A
authors.lastname: Ishibashi
authors.forename: K
authors.initials: K
authors.lastname: Hatsuse
authors.forename: M
authors.initials: M
authors.lastname: Kakihara
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D005093:Exophiala; D006801:Humans; D008297:Male; D009181:Mycoses / Q000382:microbiology* / Q000628:therapy