title: [Interferon therapy after ablation of Kent bundle for a patient with chronic hepatitis type B complicated with WPW syndrome].
abstract: Cardiotoxicity of interferon-alpha or gamma, such as fatal arrhythmia and myocardial infarction, has been reported. Therefore cardiotoxicity of interferon should be seriously considered before administration for patients with a pre-existing heart disease. We treated a patient with chronic active hepatitis type B, coexisted with Wolff-Parkinson-White syndrome, who has had frequent attacks of paroxysmal atrial fibrillation. To prevent the occurrence of fatal arrhythmia with an interferon therapy in this patient, we performed radiofrequency catheter ablation of the Kent bundle. After the successful ablation, we could safely administered recombinant interferon alpha-2b for chronic hepatitis type B.
authors.affiliation: First Department of Internal Medicine, Kyushu University 60, Fukuoka.
authors.forename: H
authors.initials: H
authors.lastname: Kusaba
authors.forename: J
authors.initials: J
authors.lastname: Kudo
authors.forename: T
authors.initials: T
authors.lastname: Kuruma
authors.forename: R
authors.initials: R
authors.lastname: Nagashima
authors.forename: M
authors.initials: M
authors.lastname: Ra
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Kaji
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
authors.forename: Y
authors.initials: Y
authors.lastname: Baba
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000517:prevention & control; D017115:Catheter Ablation; D002908:Chronic Disease; D006329:Heart Conduction System / Q000601:surgery*; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins