Radioiodination of 2'-deoxyuridine: preparation and preliminary evaluation in tumour-bearing rats.
A simple rapid procedure, using a Iodo-bead as oxidizing agent, has been developed for labelling 2'-deoxyuridine on the 5-position of the base with 123I. The labelling yield exceeds 60% and the total production time amounts to only 1 h. Biodistribution studies with 5-[123I]iodo-2'-deoxyuridine on tumour-bearing rats showed an important uptake of activity in tissue with a high cell proliferation rate (tumour, intestine) and in the liver.
Goethals
P
P
Laboratory of Analytical Chemistry, Universiteit Gent, Belgium.
Lodewyckx
W
W
van Eijkeren
M
M
Dams
R
R
D000818:Animals; D003857:Deoxyuridine / Q000493:pharmacokinetics; D005260:Female; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D009374:Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D003857:Deoxyuridine