title: Binding of nuclear proteins to transcription regulatory elements in selenium deficiency.
abstract: Dietary selenium deficiency in rats increased binding of liver nuclear proteins to DNA regulatory sequences which activate transcription in response to oxidative stress. In contrast, binding to the activator protein-1 control sequence, which is inhibited by oxidation, was decreased in selenium deficiency.
authors.affiliation: Department of Food Science and Nutrition, Brigham Young University, Provo, UT 84602.
authors.forename: M J
authors.initials: MJ
authors.lastname: Christensen
authors.forename: N W
authors.initials: NW
authors.lastname: Pusey
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005809:Genes, Regulator; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D011485:Protein Binding; D011506:Proteins; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D009687:Nuclear Proteins; D011506:Proteins; D016755:Proto-Oncogene Proteins c-jun; D015534:Trans-Activators; D004247:DNA; D005979:Glutathione Peroxidase; D012643:Selenium