[The influence of indapamide on 6-keto-PGF1 alpha, PGE2, and PGF2 alpha synthesis and plasma TXB2 levels in spontaneously hypertensive rats].
The influence of indapamide on the prostaglandin system was studied in spontaneously hypertensive rats (SHR) and compared with SHR control and normal WKY rats. The results show that the synthesis of vasoconstrictive prostaglandins (PGE2 and PGF2 alpha) in the renal medullary tissues of SHR is higher than that of normal rats, and this may have something to do with the development and maintenance of high blood pressure in SHR. After indapamide administration, the synthesis of prostacyclin in SHR aorta increased significantly as compared with the SHR control group, whereas PGE2 and PGF2 alpha production in renal medullary tissues decreased markedly. The results support the idea that the prostaglandin system, especially PGE2 and PGF2 alpha, plays an important role in the antihypertensive mechanism of indapamide.
Yan
X
X
PUMC Hospital, Beijing.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D001011:Aorta / Q000378:metabolism; D015237:Dinoprost / Q000096:biosynthesis*; D015232:Dinoprostone / Q000096:biosynthesis*; D005260:Female; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D007190:Indapamide / Q000627:therapeutic use*; D007679:Kidney Medulla / Q000378:metabolism; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D007190:Indapamide; D015232:Dinoprostone