title: Reduction of radiocesium transfer to animal products using sustained release boli with ammoniumiron(III)-hexacyanoferrate(II).
abstract: A sustained release bolus with the cesium binder ammoniumiron(III)-hexacyanoferrate (AFCF) has been developed as a countermeasure for small ruminants grazing pastures contaminated by radiocesium (134Cs+137Cs). The boli (40-50 g) are produced by compression of a mixture of AFCF, barite and wax. The release of AFCF from boli labelled with 137Cs-iron-hexacyanoferrate complex was studied in laboratory sheep. The release rate followed first order kinetics during the 108 d of observation and decreased from 40 to 22, 110 to 35 and 280 to 25 mg d-1 in sheep treated with 1, 2 or 3 boli respectively. The efficiency of boli in reducing radiocesium transfer to meat and milk was tested in laboratory studies with goats fed 134Cs tracer. Until 40 d after treatment the transfer of radiocesium to milk was reduced by 35%, 60% and 85% in goats given 1, 2 or 3 boli, respectively. The reduction in radiocesium transfer persisted for 90 d but with a lower efficiency. A similar relationship was found between number of boli and the reduction in radiocesium transfer to meat with an observed maximal reduction of 60%.
authors.affiliation: Department of Animal Science, Agricultural University of Norway, As.
authors.forename: K
authors.initials: K
authors.lastname: Hove
authors.forename: H S
authors.initials: HS
authors.lastname: Hansen
mesh_terms: D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001835:Body Weight; D002588:Cesium Radioisotopes / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D005243:Feces; D005295:Ferrocyanides / Q000494:pharmacology*; D005507:Food Contamination, Radioactive; D006041:Goats / Q000378:metabolism*; D008297:Male; D008892:Milk / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D000931:Antidotes; D002588:Cesium Radioisotopes; D003692:Delayed-Action Preparations; D005295:Ferrocyanides; C056252:ammonium iron (III) hexacyanoferrate