Effect of DL-sodium lactate infusion on excretion of purine bases and oxypurinol.
To investigate whether or not DL-sodium lactate inhibits the renal excretion of purine bases and oxypurinol, we administered physiological saline containing 0.2 mol DL-sodium lactate to 7 normal subjects intravenously. DL-sodium lactate infusion decreased the urinary excretion and the fractional clearance of uric acid, xanthine and oxypurinol, but the fractional clearance of hypoxanthine was not affected. These results suggested that the implications of DL-sodium lactate-induced hyperuricemia must be considered in patients with gout on its long term and high dose administration, and that the implications of DL-sodium lactate-induced prolongation of half-life of oxypurinol must be considered in hyperuricemic patients treated with allopurinol. However, since the high dose and long term administration of DL-sodium lactate is clinically rare, the effect of DL-sodium lactate infusion on the urinary excretion of uric acid, xanthine and oxypurinol may not be clinically important.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Moriwaki
Y
Y
Takahashi
S
S
Nasako
Y
Y
Higashino
K
K
D000328:Adult; D000493:Allopurinol / Q000494:pharmacology; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000652:urine; D007773:Lactates / Q000097:blood / Q000494:pharmacology*; D019344:Lactic Acid; D008297:Male; D010117:Oxypurinol / Q000652:urine*; D011687:Purines / Q000652:urine*; D012709:Serum Albumin / Q000032:analysis; D014527:Uric Acid / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000652:urine
D007042:Hypoxanthines; D007773:Lactates; D011687:Purines; D012709:Serum Albumin; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D019344:Lactic Acid; D000493:Allopurinol; D010117:Oxypurinol