title: Radioiodination of 2'-deoxyuridine: preparation and preliminary evaluation in tumour-bearing rats.
abstract: A simple rapid procedure, using a Iodo-bead as oxidizing agent, has been developed for labelling 2'-deoxyuridine on the 5-position of the base with 123I. The labelling yield exceeds 60% and the total production time amounts to only 1 h. Biodistribution studies with 5-[123I]iodo-2'-deoxyuridine on tumour-bearing rats showed an important uptake of activity in tissue with a high cell proliferation rate (tumour, intestine) and in the liver.
authors.affiliation: Laboratory of Analytical Chemistry, Universiteit Gent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Goethals
authors.forename: W
authors.initials: W
authors.lastname: Lodewyckx
authors.forename: M
authors.initials: M
authors.lastname: van Eijkeren
authors.forename: R
authors.initials: R
authors.lastname: Dams
mesh_terms: D000818:Animals; D003857:Deoxyuridine / Q000493:pharmacokinetics; D005260:Female; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D009374:Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D003857:Deoxyuridine