title: [Disorders of the liberation of tissue-type plasminogen activator (t-PA) from the venous wall as a cause for recurrent thromboses].
abstract: The release of tissue-type plasminogen activator (t-PA) after venous occlusion was tested in 290 patients with venous thrombosis, at earliest three months after the last thrombo-embolic episode. In 37 patients (12.8%) the t-PA-activity was decreased. In 14 patients (4.8%) the defect was confirmed by control. A reduced release of t-PA was found in 4 patients, while 10 out of 14 patients had comparatively higher levels of plasminogen-activator-inhibitor (PAI-I).
authors.affiliation: Abteilung für Innere Medizin, William Harvey-Klinik, Bad Nauheim.
authors.forename: V
authors.initials: V
authors.lastname: Hach-Wunderle
authors.forename: I
authors.initials: I
authors.lastname: Scharrer
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D015849:Plasminogen Inactivators / Q000097:blood; D012016:Reference Values; D013924:Thrombophlebitis / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator
vernacular_title: Störungen der Freisetzung von Gewebe-Plasminogen-Aktivator (t-PA) aus der Venenwand als Ursache für rezidivierende Thrombosen.