title: Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids.
abstract: Lower pre-chemotherapy night time cortisol excretion predicted more severe cisplatin induced nausea and vomiting in 42 ovarian cancer patients receiving ondansetron as a single antiemetic agent. Dexamethasone administration added to the antiemetic effect of ondansetron principally in patients who had low excretion of cortisol.
authors.affiliation: Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden.
authors.forename: T J
authors.initials: TJ
authors.lastname: Hursti
authors.forename: M
authors.initials: M
authors.lastname: Fredrikson
authors.forename: G
authors.initials: G
authors.lastname: Steineck
authors.forename: S
authors.initials: S
authors.lastname: Börjeson
authors.forename: C J
authors.initials: CJ
authors.lastname: Fürst
authors.forename: C
authors.initials: C
authors.lastname: Peterson
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology*; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D017294:Ondansetron / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D017294:Ondansetron; D003907:Dexamethasone; D004317:Doxorubicin; D002945:Cisplatin; D008558:Melphalan; D006854:Hydrocortisone