Minimizing the drainage period for continuous ambulatory peritoneal dialysis.
OBJECTIVE
To examine features of drainage flow and to determine whether the drainage period could be safely reduced in continuous ambulatory peritoneal dialysis (CAPD) patients.


METHODS
Open nonrandomized prospective study in CAPD patients.


METHODS
The kidney center in a tertiary care university hospital.


METHODS
Fourteen CAPD patients with good catheter function.


METHODS
Drainage flow pattern was studied using a 2-L dialysate. The drainage period was reduced from 28 minutes (mean) to 10 minutes throughout a short-term, 2-month study period and a long-term, 6-month study period for 10 patients.


METHODS
Ultrafiltration volume, body weight, and peritoneal clearance.


RESULTS
A kinetics analysis of the drainage period and volume indicated a positive linear correlation with two different slopes: one for rapid drainage for the first 5-7 minutes and one for subsequent slow drainage. The effluent exceeded 80% in the former period. Ultrafiltration volume and body weight showed no change due to the reduction. Improved peritoneal clearance of small molecular substances could not be confirmed despite a 5% increase in the effective dialysis period. Nearly all patients were satisfied with the reduction and desired its continuation.


CONCLUSIONS
Ten minutes is a sufficient drainage period for most CAPD patients with a 2-L dialysate volume. This may possibly allow an increase in daily activities and an effective peritoneal membrane dialysate contact period.
Kumano
K
K
Kidney Center, Kitasato University Hospital, Kanagawa, Japan.
Yokota
S
S
Sakai
T
T
Kazama
H
H
Sofue
K
K
D000328:Adult; D003404:Creatinine / Q000493:pharmacokinetics; D015314:Dialysis Solutions / Q000008:administration & dosage / Q000493:pharmacokinetics; D004322:Drainage; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000493:pharmacokinetics; D009994:Osmolar Concentration; D017060:Patient Satisfaction; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods; D010537:Peritoneum / Q000378:metabolism; D010710:Phosphates / Q000493:pharmacokinetics; D011506:Proteins / Q000493:pharmacokinetics; D013997:Time Factors; D014462:Ultrafiltration; D014508:Urea / Q000493:pharmacokinetics; D001613:beta 2-Microglobulin / Q000493:pharmacokinetics
D015314:Dialysis Solutions; D010710:Phosphates; D011506:Proteins; D001613:beta 2-Microglobulin; D014508:Urea; D003404:Creatinine; D005947:Glucose; D009584:Nitrogen