title: Association of generalized granuloma annulare with autoantibodies.
abstract: Granuloma annulare is a degenerative disease of the skin histopathologically characterized by focal degeneration of collagen with a surrounding infiltrate of lymphoid cells, histiocytic cells, and multinucleated giant cells. Immunological abnormalities such as delayed-type hypersensitivity and vasculitic origin are suspected in the pathogenesis. We describe three patients with generalized granuloma annulare, in whom autoantibodies, including antinuclear antibody, antithyroid stimulating hormone receptor antibody, and immune complex, were detected.
authors.affiliation: Department of Dermatology, Okayama University Medical School, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Tada
authors.forename: A
authors.initials: A
authors.lastname: Seno
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: J
authors.initials: J
authors.lastname: Arata
authors.forename: Y
authors.initials: Y
authors.lastname: Nagao
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D016460:Granuloma Annulare / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001323:Autoantibodies