T cell unresponsiveness in lepromatous leprosy.
T lymphocytes from patients with lepromatous leprosy are anergic to M. leprae antigens. The mechanisms which induce and maintain this antigen specific T cell unresponsiveness in lepromatous leprosy have been the subject of intensive research. Recent insights from work on T cell recognition of antigen, cytokines, and T cell subsets have considerably enhanced the understanding of the immunopathology of lepromatous leprosy.
Kamradt
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Tufts University School of Medicine, New England Medical Center, Division of Rheumatology/Immunology, Boston, MA 02111.
D000942:Antigens, Bacterial / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D015440:Leprosy, Lepromatous / Q000473:pathology / Q000503:physiopathology*; D009166:Mycobacterium leprae / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D000942:Antigens, Bacterial; D016207:Cytokines