Correlation between histopathology and linoleic acid levels in five meningioma types.
The total fatty acid compositions of neoplastic tissues in 5 different meningioma types (meningotheliomatous, transitional, vascular, fibroblastic, atypical), analysed by gas-liquid chromatography, are presented in correlation with their histopathology. The benign meningioma types (first 3) had higher relative percentages of linoleic acid, compared to the apparently malignant meningioma types (fibroblastic, atypical). From these results it is suggested that a high relative percentage of linoleic acid is characteristic of benign neoplastic growth, while a low relative percentage may correlate with increased malignancy.
Louw
L
L
Department of Anatomy and cell Morphology, Medical Faculty, University of the Orange Free State, Bloemfontein, South Africa.
van der Westhuizen
J P
JP
D015415:Biomarkers / Q000032:analysis; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis*; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D008579:Meningioma / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D011446:Prospective Studies
D015415:Biomarkers; D008041:Linoleic Acids; D019787:Linoleic Acid