Immunoelectron localization of HLA-DR, HLA-DP, and HLA-DQ antigens on the microvasculature in normal skin.
BACKGROUND
Expression of HLA-DP and HLA-DQ antigens on the microvasculature in normal skin is uncertain.


OBJECTIVE
We investigated expression of HLA-DR, HLA-DP, and HLA-DQ antigens on the microvasculature in normal skin by light and electron microscopic immunohistochemistry.


RESULTS
HLA-DP and HLA-DQ antigens were expressed on the microvasculature, but the intensity of positiveness was variable. By immunoelectron microscopy, HLA-DR, HLA-DP, and HLA-DQ antigens were expressed on the endothelial cells of the microvasculature, but not on the pericytes and the smooth muscle cells. The luminal surface of endothelial cells had a stronger expression of these antigens than the abluminal surface.


CONCLUSIONS
HLA-DR, HLA-DP, and HLA-DQ antigens are expressed on endothelial cells of the microvasculature in normal skin.
Suzumura
Y
Y
Department of Dermatology, Chubu-Rosai Hospital, Nagoya, Japan.
Ohashi
M
M
D000328:Adult; D006682:HLA-DP Antigens / Q000032:analysis* / Q000648:ultrastructure; D006683:HLA-DQ Antigens / Q000032:analysis* / Q000648:ultrastructure; D006684:HLA-DR Antigens / Q000032:analysis* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008833:Microcirculation / Q000276:immunology; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D012016:Reference Values; D012867:Skin / Q000098:blood supply*
D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens