Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other "D-2-like" agonists.
The putative D-3 dopamine receptor agonist 7-OH-DPAT (10 micrograms/kg, s.c.) reduced spontaneous activity in rats, without inducing yawning; higher doses (0.1-10.0 mg/kg, s.c.) stimulated non-stereotyped sniffing, locomotion and chewing, which were attenuated by the selective D-1 antagonist BW 737C (5.0 mg/kg, s.c.) without release of any atypical behaviours. Low doses of 7-OH-DPAT may act on inhibitory D-3 receptors, while higher doses may act at stimulatory D-3 or other "D-2-like" receptors that participate in cooperative but not oppositional interactions with D-1 receptors.
Daly
S A
SA
Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
Waddington
J L
JL
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D050637:Receptors, Dopamine D3; D044005:Tetrahydroisoquinolines; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
C493595:Drd3 protein, rat; D007546:Isoquinolines; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D044005:Tetrahydroisoquinolines; D013764:Tetrahydronaphthalenes; C075318:BW 737C89; C031349:7-hydroxy-2-N,N-dipropylaminotetralin