Effect of ergot-alkaloid dihydroergosine on the immune reaction and plasma corticosterone in rats.
Ergot-alkaloid dihydroergosine, a potential antidepressive and anxiolytic drug, suppressed humoral and cellular immune reaction in rats, if given in a single injection (2-100 mg/kg) 1 hour after immunization. Plasma corticosterone levels were decreased upon assay of the immune response, 5 or 8 days following treatment.
Smejkal-Jagar
L
L
Rudjer Boskovic Institute, Department of Experimental Biology and Medicine, Zagreb, Croatia.
Pivac
N
N
Boranic
M
M
Pericic
D
D
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000928:Antidepressive Agents / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D004876:Ergot Alkaloids / Q000494:pharmacology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000928:Antidepressive Agents; D004876:Ergot Alkaloids; D003345:Corticosterone