title: Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase.
abstract: Immunoscreening a rat liver cDNA expression library has led to the isolation of a full-length cDNA clone encoding a novel isoform of rat inositol 1,4,5-trisphosphate 3-kinase (IP3 3-kinase). Sequence comparison shows it (i) to be 93% identical to human hippocampus IP3 3-kinase B over 468 residues at the protein level, and (ii) to encode a protein 204 amino acids larger than the published sequence of its human homologue.
authors.affiliation: Department of Biochemistry, University of Bristol, UK.
authors.forename: S
authors.initials: S
authors.lastname: Thomas
authors.forename: B
authors.initials: B
authors.lastname: Brake
authors.forename: J P
authors.initials: JP
authors.lastname: Luzio
authors.forename: K
authors.initials: K
authors.lastname: Stanley
authors.forename: G
authors.initials: G
authors.lastname: Banting
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D051381:Rats; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
chemical_list: D018076:DNA, Complementary; D017853:Phosphotransferases (Alcohol Group Acceptor); C051038:Inositol 1,4,5-trisphosphate 3-kinase