title: Susceptibility genes for familial Alzheimer's disease on chromosomes 19 and 21: a reality check.
abstract: Linkage data from 92 FAD kindreds were analyzed by lod score analysis under various assumptions of disease penetrance, marker allele frequencies, and heterogeneity. Multilocus linkage analysis supports the existence of a gene in 40%-65% of families with predominantly late-onset illness (after age 65) on chromosome 19 between D19S13 and ATP1A3. Evidence for a second FAD gene on chromosome 21 is weaker and stems primarily from a few families with early-onset disease. Our findings also indicate that choice of the genetic model for FAD and marker allele frequencies may be crucial to conclusions about linkage and heterogeneity.
authors.affiliation: Department of Neurology, Boston University School of Medicine, MA 02118.
authors.forename: L A
authors.initials: LA
authors.lastname: Farrer
authors.forename: L
authors.initials: L
authors.lastname: Stice
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D005190:Family; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged
chemical_list: D005819:Genetic Markers