Synthesis of some new thioethers of 1,2,4-triazine-3-hydrazones and assays for their anticancer and anti human immune virus activities.
A number of various thioethers derived from 3-hydrazone-5,6-diphenyl-1,2,4-triazines have been synthesized and evaluated for anticancer and anti HIV activities. The structures are supported by elemental analysis, IR, UV and 1H-NMR spectral data. Most of the tested compounds displayed a significant activity against Leukemia/Lymphoma, CNS, Ovarian and Small cell lung cancer.
Abdel-Rahman
R M
RM
Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt.
Seada
M
M
Fawzy
M
M
el-Baz
I
I
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006678:HIV / Q000187:drug effects*; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D006835:Hydrazones; D014227:Triazines