title: [Clinico-radiological correlation in thalassemia intermedia].
abstract: Fifteen thalassemia intermedia patients were considered, whose clinical and radiological findings were examined and compared. Eight patients underwent regular transfusion therapy. All patients underwent total body CT: the volume of ectopic erythropoiesis foci was calculated by a digital calculation algorithm (ROI volume). This work was aimed at correlating the quantitative measures of ectopic erythropoiesis assessed by CT with serum level of erythropoietin (EPO) and of trasferrin-free receptors (TfR) in both transfused and non-transfused patients, also considering the volume changes of ectopic erythropoiesis and bone changes over 36 months' follow-up. A direct correlation was demonstrated between serum transferrin and ectopic erythropoietic masses in transfusion-dependent patients: in fact, increased values of serum transferrin correspond to the enlargement of these masses and to bone lesion worsening.
authors.affiliation: Istituto di Radiologia, Università degli Studi di Roma Tor Vergata, Ospedale S. Eugenio, Roma.
authors.forename: G
authors.initials: G
authors.lastname: Sergiacomi
authors.forename: E
authors.initials: E
authors.lastname: Palma
authors.forename: P
authors.initials: P
authors.lastname: Cianciulli
authors.forename: L
authors.initials: L
authors.lastname: Forte
authors.forename: G
authors.initials: G
authors.lastname: Papa
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D008297:Male; D011990:Receptors, Transferrin / Q000032:analysis; D014057:Tomography, X-Ray Computed; D017086:beta-Thalassemia / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D011990:Receptors, Transferrin; D004921:Erythropoietin
vernacular_title: Correlazioni clinico-radiologiche nella talassemia intermedia.