Exogenous neuropeptide Y blocks myoelectric activity in the upper gastrointestinal tract of starved dogs. Brain neuropeptide Y converts a fasting pattern of myoelectric activity to a fed pattern.
The effect of intracerebroventricular (ICV) neuropeptide Y (NPY) on the migrating motor complex (MMC) was examined in five starved dogs. Myoelectric activity was recorded using gastric, duodenal, and jejunal electrodes. Intragastric pressure was monitored via a gastric fistula, and ICV injections were given through a cerebroventricular guide. Recordings were made with no ICV injection and before and after 250-microliters bolus injections of vehicle as control (0.1% dog serum albumin in saline) or 500 pmol/kg NPY. The mean interval between MMCs was 98 +/- 10 min without ICV injection and 96 +/- 7 min after control solution. After ICV injection of NPY no further MMCs were recorded in any dog, even though the study was continued for a minimum of 3.5 h. Instead, the myoelectric pattern became indistinguishable from that in fed dogs. We conclude that central NPY plays a role in modulation of upper gastrointestinal myoelectric activity. This may reflect a central regulatory role for NPY in the coordination of feeding.
Thomson
H J
HJ
Division of Gastrointestinal Surgery, Duke University Medical Center, Durham, North Carolina 27710.
Geoghegan
J G
JG
Farouk
M
M
Saperstein
L A
LA
Chung
K
K
Meyers
W C
WC
Pappas
T N
TN
D000818:Animals; D001921:Brain / Q000502:physiology; D004285:Dogs; D005215:Fasting / Q000502:physiology*; D005260:Female; D005502:Food; D005769:Gastrointestinal Motility / Q000502:physiology*; D007276:Injections, Intraventricular; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D013997:Time Factors
D009478:Neuropeptide Y