title: MR imaging of blood oxygenation-dependent changes in focal renal ischemia and transplanted liver tumor in rat.
abstract: The potential of using fast magnetic resonance (MR) imaging in conjunction with apnea-induced blood deoxygenation for the noninvasive monitoring of relative perfusion in the rat abdomen has been studied with two experimental models: glycerol-induced focal renal ischemia and transplanted liver tumor. Gradient-echo echo-planar imaging (GRE-EPI) (TE of 20 msec at 2T) of liver and kidney was performed before, during, and after a 60-second apnea episode and then was followed in the same rat by contrast-enhanced (a) GRE-EPI and (b) T1-weighted spin-echo imaging (TR msec/TE msec = 200/6) with polylysine-(gadolinium-DTPA [diethylenetriaminepentaacetic acid]). The results indicate that a noninvasive vascular challenge due to apnea can be used for the detection of focal tissue perfusion abnormalities in rat kidney and liver tumor.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143-0628.
authors.forename: V S
authors.initials: VS
authors.lastname: Vexler
authors.forename: A J
authors.initials: AJ
authors.lastname: de Crespigny
authors.forename: M F
authors.initials: MF
authors.lastname: Wendland
authors.forename: R
authors.initials: R
authors.lastname: Kuwatsuru
authors.forename: A
authors.initials: A
authors.lastname: Mühler
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
authors.forename: M E
authors.initials: ME
authors.lastname: Moseley
mesh_terms: D000818:Animals; D017352:Echo-Planar Imaging; D007511:Ischemia / Q000097:blood / Q000175:diagnosis*; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000175:diagnosis*; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010100:Oxygen