[The effect of peptide-type epiphyseal hormones on the functional activity of the human thyroid in vitro. The action of epiphyseal peptides on the accumulation of cyclic nucleotides in the normal human thyroid and on its secretory activity].
Effects of pineal peptides on the accumulation of cyclic nucleotides of the human thyroid and its secretory activity were analysed on the basis of the data obtained after operation from patients with nodular euthyroid goiter) incubated with Epithalamine and Epiphisan, were studied. It was shown, that pineal peptides not only inhibited thyroid secretion function and cAMP accumulation, but also acted as modifiers of TSH stimulatory effects.
Rom-Bugoslavskaia
E S
ES
Gal'chinskaia
V Iu
VIu
Komarova
I V
IV
D000818:Animals; D002417:Cattle; D046508:Culture Techniques; D006044:Goiter, Nodular / Q000503:physiopathology; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D012016:Reference Values; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism
D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D009712:Nucleotides, Cyclic; D010455:Peptides; C085956:epiphisan; C027437:epithalamin
Vliianie épifizarnykh gormonov peptidnoĭ prirody na funktsional'nuiu aktivnost' shchitovidnoĭ zhelezy cheloveka v usloviiakh in vitro. Vozdeĭstvie épifizarnykh peptidov na akkumuliatsiiu tsiklicheskikh nukleotidov v normal'noĭ shchitovidnoĭ zheleze cheloveka i ee sekretornuiu aktivnost'.