title: [Drug-induced liver disease: experiences of the Swiss Center for Adverse Drug Effects 1989-1991].
abstract: Drug-induced liver disease can mimic any form of acute or chronic liver disease. Suspected drug-induced liver disease makes up between 4 and 7% of all reports of adverse drug effects voluntarily reported to central registries. We report on all patients with drug-induced hepatotoxic reactions voluntarily reported to the Swiss Adverse Drug Reaction Center from 1989 to 1991. In that period there was a total of 2084 reports of which 140 (6.7%) concerned the liver. In 16 cases two drugs were simultaneously involved, so that 156 investigations were carried out. We found a causal relationship in 123 cases. Antibiotic and chemotherapeutic agents were the drugs most frequently involved. There were seven fatal cases (5%). Our data correspond with the data in the literature. Regarding the amount of drugs prescribed, the hepatic adverse effect can be regarded as common.
authors.affiliation: Medizinische Klinik, Kantonsspital Chur.
authors.forename: B
authors.initials: B
authors.lastname: Werth
authors.forename: M
authors.initials: M
authors.lastname: Kuhn
authors.forename: K
authors.initials: K
authors.lastname: Hartmann
authors.forename: E
authors.initials: E
authors.lastname: Kobler
authors.forename: W H
authors.initials: WH
authors.lastname: Reinhart
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D002648:Child; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D013557:Switzerland / Q000453:epidemiology
vernacular_title: Medikamentöse Hepatopathien: Erfahrungen der Schweizerischen Arzneimittel-Nebenwirkungs-Zentrale (SANZ) 1989-1991.