[Ultrastructural study of azidothymidine-induced melanoderma in an AIDS patient].
We report an ultrastructural study of azidothymidine-induced melanoderma. The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis, and in dermal Factor XIIIa-positive dendrocytes. Such observation suggests an increased melanogenesis in melanocytes associated to a defect in the degradation of melanosomes normally occurring during epidermal maturation.
Hermanns-Lê
T
T
Service de Dermatopathologie, CHU du Sart Tilman, Université de Liège.
Gérardy-Goffin
F
F
Giet-Lesuisse
M
M
Piérard
G E
GE
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000473:pathology*; D012867:Skin / Q000648:ultrastructure; D015215:Zidovudine / Q000009:adverse effects*
D015215:Zidovudine
Etude ultrastructurale de la mélanodermie induite par l'azidothymidine chez un patient sidéen.