title: Histocompatibility antigens and La Crosse encephalitis.
abstract: Major histocompatibility complex antigens (HLA-ABC and -DR loci) on lymphocytes from 79 patients with La Crosse encephalitis were compared with those of 69 control subjects. Nine patients (11%) and none of the control population had HLA-B49 (P < .01, uncorrected for multiple comparisons). Of La Crosse encephalitis patients with acute-phase seizures, only 2 (7%) were positive for HLA-DR5, whereas 16 (37%) of nonseizure patients were positive for that antigen (P < .025). These findings suggest that susceptibility and complications associated with this disease may have an immunogenetic component.
authors.affiliation: Department of Laboratory Medicine, Lutheran Hospital-La Crosse, Wisconsin.
authors.forename: K L
authors.initials: KL
authors.lastname: Case
authors.forename: R M
authors.initials: RM
authors.lastname: West
authors.forename: M J
authors.initials: MJ
authors.lastname: Smith
mesh_terms: D002141:Encephalitis Virus, California; D004670:Encephalitis, California / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens