Immunohistochemical study of oral keratoses including lichen planus.
Biopsies of non-ulcerated oral mucosa from 13 patients with oral lichen planus and 12 patients with leukoplakia were immunohistochemically stained using monoclonal antibodies to pan T, pan B, T helper and T suppressor/cytotoxic cells and the stained lymphocytes enumerated using an image analyser. The results show the preponderance of T cells infiltrating both oral lichen planus and leukoplakia. The T helper: T suppressor/cytotoxic cell ratio was the same (1:2) for both oral lichen planus and leukoplakia. A similar proportion of T suppressor/cytotoxic cells was found infiltrating the epithelium. These data indicate that T cell subset analysis is of no value in distinguishing oral lichen planus from other oral keratoses.
Robertson
W D
WD
Department of Oral Medicine & Oral Pathology, University of Edinburgh, Scotland.
Wray
D
D
D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D016516:CD4-CD8 Ratio; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000175:diagnosis / Q000276:immunology*; D008010:Lichen Planus / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis / Q000276:immunology*; D009061:Mouth Mucosa / Q000276:immunology; D016176:T-Lymphocyte Subsets
D000911:Antibodies, Monoclonal