[Evaluation of renal uptake on 111InCl3 bone marrow scintigraphy in patients with aplastic anemia and myelodysplastic syndrome].
High renal uptake on bone marrow scan with indium-111 chloride is often shown in patients with bone marrow abnormality. We evaluated the renal uptake on bone marrow scan in 27 cases with aplastic anemia, 20 cases with myelodysplastic syndrome (MDS) and 10 cases with other diseases. The high renal uptake was observed in patients not only with aplastic anemia but also with MDS. The renal uptake correlated with blood transfusion units, unsaturated iron binding capacity (UIBC), blood pool imaging and bone marrow uptake. The renal uptake correlated with UIBC better than with the blood transfusion units. Following mechanism of the renal uptake is proposed that frequent blood transfusion makes low UIBC, and the low UIBC causes the failure to chelate indium with transferrin. The fast blood clearance of un-chelated indium via kidneys is followed. Hypoplastic bone marrow may also play an important role for the high renal uptake because all patients with the high renal uptake could not be explained by above mentioned mechanisms. Caution should be paid to the scans with the high renal uptake because both aplastic anemia and MDS patients show the high renal uptake.
Koizumi
M
M
Department of Radiology, Dokkyo Medical University.
Goto
M
M
Nomura
T
T
Watari
T
T
Saito
K
K
D000741:Anemia, Aplastic / Q000000981:diagnostic imaging* / Q000378:metabolism; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D006801:Humans; D007204:Indium / Q000493:pharmacokinetics*; D007205:Indium Radioisotopes / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D009190:Myelodysplastic Syndromes / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging
D007205:Indium Radioisotopes; D007204:Indium; C020758:indium trichloride