Osteoporosis: assessment of bone loss and remodeling.
Osteoporosis, the most common metabolic bone disorder, is a major health problem in older individuals, and especially in postmenopausal women throughout the world. It is characterized by low bone mass, structural deterioration, and an increased risk of fracture. The expected growth in the percentage of the world population over 65 years of age suggests that control of the chronic diseases of the elderly must be a major international priority. In order to design and implement appropriate prevention and treatment strategies for osteoporosis, it is necessary to assess the extent of the disease or condition in populations, and in individuals in a clinical setting. This review focuses on available and emerging techniques to measure bone mass or density, and on the role of biochemical markers of bone remodeling in the prediction of future bone loss. In order to prevent a disease that progresses without any obvious symptoms, it is important to determine not only the current status of bone mass and remodeling but also to develop methods to predict future bone loss. Different information is derived from each of the assessment approaches, and a combination of measures may be necessary to develop accurate predictive models.
McGowan
J A
JA
Bone Biology and Bone Diseases Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892.
D015502:Absorptiometry, Photon; D000368:Aged; D015415:Biomarkers; D015519:Bone Density; D001846:Bone Development; D016723:Bone Remodeling; D005260:Female; D050723:Fractures, Bone / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000503:physiopathology* / Q000517:prevention & control; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology; D011379:Prognosis; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
D015415:Biomarkers; D015675:Osteocalcin