Transgenic animals as tools in drug development.
A transgenic animal can be defined as an organism that has undergone a stable modification of genotype as a result of genetic manipulation. Such animals are being increasingly employed as research and development tools by both academic and commercial institutions. The primary methods by which transgenic animals can be generated will be described. The relative merits of the approaches will be illustrated, as will their potential use in the discovery and development of novel therapeutic entities.
Harris
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S
Glaxo Group Research Ltd., Greenford, Middlesex, UK.
Davis
N K
NK
Jowett
M I
MI
Rees
E S
ES
Topps
S
S
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D015195:Drug Design