Comparison of the effects of intra-arterial and intravenous cisplatin on foot tumors and survival of rats bearing lung metastases.
The therapeutic efficacy on intra-arterial (IA) and intravenous (IV) cisplatin on both foot tumors and lung metastases of transitional cell carcinoma RBT-1 in rats was compared. 5 mg/kg of either IA or IV cisplatin was administered to rats bearing both a foot tumor and pulmonary metastases. The antitumor effects on foot tumors were evaluated by changes in paw volume, foot weight and tumor area, and on lung metastases by a prolongation in life span after the amputation of the affected limb. IA cisplatin had remarkable therapeutic efficacy on the foot tumor as compared with IV cisplatin. Life span prolongation was obtained by both the IA and IV infusion. However, there was no significant difference between the survival of the rats given IV and those given IA cisplatin. These results indicate that IA cisplatin is more effective than IV cisplatin on primary tumors, and the effects of IA and IV cisplatin on lung metastases and survival are similar.
Tanaka
K
K
Department of Orthopedic Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Iwamoto
Y
Y
Sugioka
Y
Y
D000671:Amputation, Surgical; D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005528:Foot / Q000601:surgery; D005534:Foot Diseases / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary*; D009368:Neoplasm Transplantation; D051381:Rats; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000473:pathology
D002945:Cisplatin