Effect of ignoring genotype-environment interaction on segregation analysis of quantitative traits.
Thirty replicates of 200 nuclear families (6 members each) were generated under three GxE interaction models. Segregation analyses of these data were performed using a regressive model taking into account an interaction effect or not. Results showed that ignoring the GxE interaction markedly decreased the power for accepting a major gene and led to serious bias in parameter estimates.
Tiret
L
L
INSERM, Unité 258, Paris, France.
Abel
L
L
Rakotovao
R
R
D000328:Adult; D002675:Child, Preschool; D003327:Coronary Disease / Q000235:genetics*; D004777:Environment; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009010:Monte Carlo Method; D012044:Regression Analysis