Angiotensin-responsive aldosterone-producing adenomas: postoperative disappearance of aldosterone response to angiotensin.
1. Nineteen out of 47 patients (40%) with confirmed unilateral aldosterone-producing adenoma (APA) were responsive to low-dose angiotensin II infusion (AII-R), as defined by an increase in plasma aldosterone concentration of > 50% over basal at 2 ng/kg per min for 60 min. 2. Seven to ten days after unilateral adrenalectomy, aldosterone was no longer responsive to angiotensin infusion in AII-R APA (100%, n = 17). Therefore, angiotensin responsiveness resides within the adenoma in AII-R APA. 3. The upright posture test for the differentiation of adenoma from hyperplasia was unreliable for the AII-R APA (26%), but generally reliable in the angiotensin-unresponsive subtype, (AII-U APA, 96%). 4. The reported predominance of females in APA was seen in AII-U APA (68%), but was reversed in AII-R APA (37%).
Tunny
T J
TJ
Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.
Klemm
S A
SA
Stowasser
M
M
Gordon
R D
RD
D000236:Adenoma / Q000097:blood* / Q000601:surgery; D000302:Adrenal Cortex / Q000378:metabolism*; D000306:Adrenal Cortex Neoplasms / Q000097:blood* / Q000601:surgery; D000315:Adrenalectomy; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood; D008297:Male; D011863:Radioimmunoassay
D000804:Angiotensin II; D000450:Aldosterone