The relationship of serum dehydroepiandrosterone and its sulfate to subsequent cancer of the prostate.
Levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) in sera collected and frozen in 1974 were studied among 81 prostate cancer cases diagnosed in the following 12 years and 81 age- and race-matched controls. Although mean levels of DHEA were 11% lower among cases than controls and DHEA-S levels were 12% lower than among controls, no dose-response association was noted for either DHEA or DHEA-S. It seems unlikely that serum levels of DHEA or DHEA-S are important risk factors for prostate cancer.
Comstock
G W
GW
Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205.
Gordon
G B
GB
Hsing
A W
AW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate; D006801:Humans; D008297:Male; D017533:Marital Status; D008396:Maryland / Q000453:epidemiology; D016555:Matched-Pair Analysis; D008875:Middle Aged; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate