[The selection of the indices of antidote efficacy].
The application of the following new indices of the efficacy of antidotes has been substantiated and discussed: the "antidotal potency" as a ratio of LD50 of a poison when an antidote used to LD99 in control intact animals, and the "index of solid protection" as a ratio of LD10 in the experiments to LD90 in controls. The two indices are true for changing the lethality curve slope, which makes it impossible to use the currently accepted "protection index" as a ratio of LD50 in experiments to LD50 in controls.
Prozorovskiĭ
V B
VB
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D010261:Paraoxon / Q000506:poisoning / Q000633:toxicity; D011041:Poisoning / Q000188:drug therapy
D000931:Antidotes; D010261:Paraoxon
Vybor pokazateleĭ éffektivnosti protivoiadiia.