[Intravesical instillation of BCG for the bladder cancer: relationship between effect and immune cells in peripheral blood and bladder wall].
Immunohistochemical technique was used to investigate the immune cells both in the peripheral blood and the bladder wall of the bladder cancer patients before and after intravesical instillation of BCG. CD4+ and the ratio of CD4+/CD8+ in the responders were significantly higher than that in the nonresponders in peripheral blood. The immune cells of all the patients received BCG instillation were increased in the bladder wall. The CD4+/CD8+ ratio was 2.007 and 0.656 in responders and nonresponders respectively. The antitumor activity of BCG was shown by the increasing of CD4+ cells. The infiltrating degree of the immune cells would be decreased with time. It would be valuable to give maintenance treatment.
Chen
L Z
LZ
First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou.
D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D001500:BCG Vaccine / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000628:therapy*
D001500:BCG Vaccine