Reduced secretion of interleukin-1 and tumor necrosis factor-alpha by neonatal monocytes.
Monocytes were isolated from peripheral blood of preterm and term newborn infants and adult controls, and their capacity to secrete the inflammatory mediators interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) was investigated. Lipopolysaccharide (LPS)-stimulated neonatal monocytes secreted significantly less IL-1 (median: 1.1 U/ml) than monocytes from adult controls (median: 7.3 U/ml). In addition TNF-alpha production by LPS-stimulated neonatal monocytes (median: 610 pg/ml) was significantly lower when compared with controls (median: 2230 pg/ml). Our data provide evidence that neonatal monocytes have a profoundly impaired cytokine secretion.
Peters
A M
AM
Department of Pediatrics, University of Göttingen, FRG.
Bertram
P
P
Gahr
M
M
Speer
C P
CP
D000328:Adult; D001724:Birth Weight; D004198:Disease Susceptibility; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood / Q000276:immunology*; D007234:Infant, Premature / Q000097:blood / Q000276:immunology*; D007239:Infections / Q000276:immunology; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha