The pathophysiology of Trypanosoma congolense infection in Scottish blackface sheep. Influence of dietary protein.
The intensity of parasitaemia, degree of anaemia, blood biochemical changes and live weight gains were measured in two groups of Scottish Blackface sheep infected experimentally with bloodstream forms of Trypanosoma congolense and given either a high or a low protein diet. It was observed that infected animals on a high protein diet tended to develop a higher intensity of parasitaemia than those on a low protein diet. Both groups of infected sheep exhibited similar degrees of anaemia, but the erythropoietic activity, as judged by the increase in mean corpuscular volume and appearance of normoblasts in the circulation, was significantly greater in animals on a high protein diet. The infected animals on a high protein diet gained weight at a similar rate to their uninfected controls, while those on a low protein diet gained significantly less than their controls between 0 and 70 days after infection. Following treatment with the trypanocidal drug isometamidium chloride, both infected groups recovered from the anaemia. However, the rate of recovery was faster in animals on a high protein diet than in those on a low protein diet. It was concluded that high protein intake ameliorates the adverse effects arising from infection, as assessed by the severity of anaemia and weight changes, and also enhances the rate of recovery following chemotherapy.
Katunguka-Rwakishaya
E
E
University of Glasgow Veterinary School, UK.
Parkins
J J
JJ
Fishwick
G
G
Murray
M
M
Holmes
P H
PH
D000740:Anemia / Q000097:blood / Q000209:etiology / Q000662:veterinary; D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004435:Eating; D004906:Erythrocyte Count / Q000662:veterinary; D004909:Erythrocyte Indices / Q000662:veterinary; D005230:Fatty Acids, Nonesterified / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D010617:Phenanthridines / Q000627:therapeutic use; D012709:Serum Albumin / Q000032:analysis; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D015430:Weight Gain
D004044:Dietary Proteins; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010617:Phenanthridines; D012709:Serum Albumin; D014344:Trypanocidal Agents; C000702:isometamidium chloride