Biochemical correlates of aortic distensibility in vivo in normal subjects.
1. Non-invasive aortic compliance measurements have been used previously to assess the distensibility of the aorta in several pathological conditions associated with increased cardiovascular risk. In adult patients with familial hypercholesterolaemia and those with growth hormone deficiency, aortic compliance has been found to correlate inversely with plasma cholesterol levels and age. We set out to establish if a relationship existed between the biophysical measurement of aortic compliance and biochemical variables in normal healthy adult subjects. 2. Blood pressure-corrected aortic distensibility, fasting insulin, insulin-like growth factor-I, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol and triacylglycerol were measured in 38 (18 males, 20 females) normotensive healthy adults. 3. Blood pressure-corrected aortic distensibility was found to correlate inversely with age (r = -0.67, P < 0.001), low-density lipoprotein-cholesterol (r = -0.37, P < 0.02) and the low-density lipoprotein-/high density lipoprotein-cholesterol ratio (r = -0.33, P < 0.05) and positively with insulin-like growth factor-I (r = 0.47, P < 0.01). On separate analysis by sex, significant inverse correlations were observed in females between aortic distensibility and total cholesterol (r = -0.50, P < 0.02), low-density lipoprotein-cholesterol (r = -0.55, P < 0.01) and age (r = -0.74, P < 0.001). A positive correlation was found between aortic distensibility and insulin-like growth factor-I (r = 0.48, P < 0.05). On forced stepwise regression analysis, however, only age (P < 0.02) was found to be significant. In males, an inverse correlation was found between aortic distensibility and age (r = -0.57, P < 0.01), low-density lipoprotein-cholesterol (r = -0.51, P < 0.05), and the low-density lipoprotein-/high-density lipoprotein-cholesterol ratio (r = -0.63, P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Hopkins
K D
KD
Department of Endocrinology and Chemical Pathology, United Medical School, University of London, Guy's Hospital, U.K.
Lehmann
E D
ED
Gosling
R G
RG
Parker
J R
JR
Sönksen
P H
PH
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D001011:Aorta / Q000502:physiology*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003187:Compliance; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D012016:Reference Values; D012737:Sex Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol