[Structural chromosomal reorganizations and mosaicism in the parents of children with Down's syndrome].
As to the authors' data 73% of women who gave birth to children with Down's syndrome (DS) (191 out of 231) were younger than 35 years. In this "young" group 191 couples were examined caryologically, 9 individuals having balanced translocations and 4 persons having mosaicism with a little trisomic clone were revealed. Mean ages of these parents are 24.3 for women and 32.5 for men. The rate of chromosome aberrations is 1.95% that is 8 times higher than in general population of newborns. 0.85% of examinees had heavy detectable mosaicism. Hence, no less than 5.6% of families with DS child, that are not subjected to a prenatal diagnostics because of young age, have different chromosome aberrations causing high risk of birth of an abnormal child.
Butomo
I V
IV
Kovaleva
N V
NV
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000209:etiology / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D009030:Mosaicism / Q000235:genetics*; D014178:Translocation, Genetic
Strukturnye khromosomnye perestroĭki i mozaitsizm u roditeleĭ deteĭ s bolezn'iu Dauna.