Synthesis of N-[tris[2-[[N-(benzyloxy)amino]carbonyl]ethyl]methyl]succinamic acid, trisuccin. Hydroxamic acid derivatives as a new class of bifunctional chelating agents.
In an effort to generate bifunctional chelating agents (BCAs) with improved labeling, conjugation, and biodistribution properties, the synthesis of trisuccin is reported. This new hydroxamate BCA, after synthesis and characterization, was used for conjugation and radiolabeling of monoclonal antibodies with 99mTc. This new class of synthetic BCAs may be useful in the radioimmunodiagnosis and radioimmunotherapy of cancer.
Safavy
A
A
Department of Radiation Oncology, University of Alabama, Birmingham 35233.
Buchsbaum
D J
DJ
Khazaeli
M B
MB
D000911:Antibodies, Monoclonal; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002855:Chromatography, Thin Layer; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000922:Immunotoxins / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry; D013667:Technetium / Q000737:chemistry
D000911:Antibodies, Monoclonal; D002614:Chelating Agents; D003432:Cross-Linking Reagents; D006877:Hydroxamic Acids; D000922:Immunotoxins; D013386:Succinates; C082055:trisuccin; D013667:Technetium