[The pharmacokinetic and pharmacodynamic characteristics of moradol in parturients during obstetrical analgesia].
Pharmacokinetic and pharmacodynamic monitoring of moradol (2 mg) given to 16 somatically healthy parturients during analgesia of spontaneous labor has identified 2 groups of patients who significantly differed in kinetic characteristics and in the drug's ability to penetrate through the placenta barrier. At the same time there were no significant differences in autonomic nervous function and central hemodynamics after intravenous moradol analgesia. The newborns from the two groups had identical high scores (8-9). Moradol produced an adequate analgesic effects in all parturients, reaching its peak at min 30-45 and lasting up to 2 hours. There was a high correlation between the plasma drug concentration and pharmacodynamic indices in parturients.
Sariev
A K
AK
Zherdev
V P
VP
Kozhakhmetov
A N
AN
Proshina
I V
IV
D000328:Adult; D016362:Analgesia, Obstetrical / Q000706:statistics & numerical data; D002077:Butorphanol / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D010147:Pain Measurement / Q000706:statistics & numerical data; D011247:Pregnancy; D012044:Regression Analysis; D013997:Time Factors
D002077:Butorphanol
Osobennosti farmakokinetiki i farmakodinamiki moradola u rozhenits na protiazhenii obezbolivaniia rodov.