Sarafotoxins and endothelins: evolution, structure and function.
The venom of the burrowing asp Atractaspis engaddensis contains several 21 amino acid residue peptides known as sarafotoxins. The sarafotoxins are homologous to the mammalian endothelin family, and they have similar biological activities. This review covers recent advances in the study of the chemical and biological properties of the sarafotoxins and endothelins.
Kochva
E
E
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
Bdolah
A
A
Wollberg
Z
Z
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D016232:Endothelins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D014757:Viper Venoms / Q000737:chemistry / Q000494:pharmacology*
D016232:Endothelins; D014757:Viper Venoms; C057354:sarafotoxins s6