[Antioxidant regulation of the changes in liver excretory function in toxic hepatitis].
The effects of the anthelmintic agent chloxyl given to rabbits in different doses were compared with those of CCl4 on the excretory function of the liver. There was a similarity of the above agents in their inhibitory effects on hepatic excretory function. The hepatoprotective effect of the antioxidant sodium selenite was found to be more pronounced than that of vitamin E. The combination of the above antioxidants was most effective in normalizing the excretory function of the liver affected by CCl4 and chloxyl, revealing the potentiation of their effect.
Vinogradova
L F
LF
Mirzoian
Zh A
ZhA
D000208:Acute Disease; D000818:Animals; D000871:Anthelmintics / Q000633:toxicity; D000975:Antioxidants / Q000627:therapeutic use*; D002251:Carbon Tetrachloride / Q000633:toxicity; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D011817:Rabbits; D013997:Time Factors; D014992:Xylenes / Q000633:toxicity
D000871:Anthelmintics; D000975:Antioxidants; D014992:Xylenes; C000294:hexachloro-4-xylene; D002251:Carbon Tetrachloride
Reguliatsiia antioksidantami izmeneniĭ ékskretornoĭ funktsii pecheni pri toksicheskom gepatite.