[The effect of verapamil and nifedipine on the systemic hemodynamics and liver macro- and microcirculations in rats with acute massive blood loss].
Systemic hemodynamics and hepatic macro- and microcirculation (ultrasonic technique, biomicroscopy) were studied in intact rats and rats with acute massive hemorrhage after intravenous administration of the calcium antagonists verapamil and nifedipine. It was shown that verapamil deteriorated the posthemorrhagic period in rats with decompensated hemorrhage which was associated with the specific features of the calcium antagonist on the cardiovascular system of intact rats (decrease of blood pressure, total peripheral resistance, heart power). In rats with compensated hemorrhage verapamil and nifedipine blocked the development of posthemorrhagic liver microcirculatory disturbances, improved hepatic tissue perfusion and stabilized portal organ blood flow velocity on the longer period than in the untreated group of rats.
Kovalenko
N Ia
NIa
Matsievskiĭ
D D
DD
D000208:Acute Disease; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects*; D006470:Hemorrhage / Q000188:drug therapy / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects*; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D014700:Verapamil; D009543:Nifedipine
Vliianie verapamila i nifedipina na sistemnuiu gemodinamiku i pechenochnuiu makro- i mikrotsirkuliatsiiu u krys s ostroĭ massivnoĭ krovopotereĭ.