title: [Surgical treatment of adult secundum ASD with severe pulmonary hypertension--two case reports].
abstract: Indication and treatment of adult secundum ASD with severe PH was discussed in two surgical cases. Case 1: 32-year-old woman with dyspnea on exercise. After 100% O2 inhalation, PA systolic pressure changed from 103 to 104 mmHg, left to right shunt ratio changed from 18.2% to 52.2%, Qp/Qs changed from 1.07 to 2.08, Rp/Rs changed from 0.58 to 0.28, PVR changed from 1606 to 805 dyne.sec.cm-5 respectively. Because the reversibility of pulmonary obstructive disease was recognized, ASD closure was performed. Her activity became well, and PVR was decreased to 758 after the operation. Case 2: 63-year-old man with dyspnea on exercise. After 100% O2 inhalation, PA systolic pressure changed from 102 to 95 mmHg, Left to right shunt ratio changed 31.9 to 51.0%, Qp/Qs changed from 1.30 to 2.0, Rp/Rs changed from 0.65 to 0.39, PVR changed from 1257 to 806 dyne.sec.cm-5. After the operation, he got well, and PA systolic pressure was decreased to 85 mmHg, PVR was 620. 100% O2 inhalation test was valuable to evaluate the reversibility of pulmonary obstructive state and to decide the surgical indication.
authors.affiliation: Department of Cardiovascular Surgery, Omiya Medical Center, Jichi Medical School, Saitama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Mizuhara
authors.forename: T
authors.initials: T
authors.lastname: Ino
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: H
authors.initials: H
authors.lastname: Ide
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Kawahito
mesh_terms: D000328:Adult; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D011300:Preoperative Care; D011652:Pulmonary Circulation / Q000187:drug effects
chemical_list: D010100:Oxygen