Effects of indeloxazine HCl on kindled amygdaloid seizures in rats: comparison with the effects of phenytoin, diazepam, ethanol, and imipramine.
The anticonvulsant effect of [(+/-)-2-[(inden-7-yloxy)methyl]morpholine (indeloxazine) HCl, a new cerebral activator, was investigated in rats against kindled seizures from the amygdala, an assumed model of secondarily generalized seizures in human. Indeloxazine (0.25-10 mg/kg, IP) dose-dependently depressed the kindled seizure and shortened the evoked amygdaloid afterdischarge. A high dose of indeloxazine (40 mg/kg, IP), however, induced generalized seizures. Comparison of the effects on the kindled seizures of indeloxazine to those of phenytoin, diazepam, ethanol, and imipramine revealed that the anticonvulsant actions of indeloxazine are similar to those of imipramine but not to those of phenytoin, ethanol, and diazepam. The results suggest that indeloxazine may exert its action through the monoaminergic system in the brain.
Nakamura
J
J
Department of Neuropsychiatry, Kurume University School of Medicine, Japan.
Anraku
T
T
Shirouzu
M
M
Iwashita
Y
Y
Nakazawa
Y
Y
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D009025:Morpholines; D000431:Ethanol; D010672:Phenytoin; C020852:indeloxazine; D007099:Imipramine; D003975:Diazepam