title: Effect of antigen-specific immunoadsorption on antibody kinetics in a rat model.
abstract: The investigation of antibody kinetics following antigen-specific immunoadsorption in alkaline phosphatase immunized rats revealed significantly lower antibody levels than in untreated controls over a follow-up period of 6 weeks. A rebounding antibody synthesis as a result of specific depletion was not observed. Non-adsorption of specific antiidiotypic antibodies may explain these findings.
authors.affiliation: 2nd Medical Clinic, Univ. of Kiel, FRG.
authors.forename: R A
authors.initials: RA
authors.lastname: Zeuner
authors.forename: R
authors.initials: R
authors.lastname: Béress
authors.forename: J O
authors.initials: JO
authors.lastname: Schroeder
authors.forename: H H
authors.initials: HH
authors.lastname: Euler
mesh_terms: D000469:Alkaline Phosphatase / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000302:isolation & purification* / Q000378:metabolism; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology*; D003488:Cyanogen Bromide / Q000737:chemistry; D005260:Female; D007114:Immunization; D007163:Immunosorbent Techniques; D008954:Models, Biological; D051381:Rats; D017207:Rats, Sprague-Dawley; D012685:Sepharose / Q000737:chemistry
chemical_list: D000906:Antibodies; D000941:Antigens; D012685:Sepharose; D000469:Alkaline Phosphatase; D003488:Cyanogen Bromide