[The role of prostaglandins in fertility. Experimental research].
Prevention of postoperative adhesion is an issue that continues to elude the abdominal and reproductive surgeon. Adhesions seem to be a result of an inflammatory process and it is well known that prostaglandins play an important role in such an event. In an attempt to improve the results of microsurgery, we have tried in this study to examine the effect of local intraperitoneal application of prostaglandins (PGE2 and PGF2 alpha) on adhesion formation in the rat after traumatizing to the uterine horn. Prostaglandins applied locally were found to increase intraperitoneal adhesion formation at the injured sites, in comparison with controls. Also, we have reported on histological examination an increased accumulation of inflammatory cells in traumatized areas. However, we didn't observe a reduced fertility in rats treated with prostaglandins because these substances induce follicular rupture by activation of proteolytic enzyme located in the follicular wall. We conclude that prostaglandins play an important role in the process of adhesion formation. Using antiprostaglandins agents could improve the outcomes of reproductive surgery.
Formelli
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G
I Clinica Ostetrica e Ginecologica P. Sfameni, Università degli Studi di Bologna.
Rinaldi
A M
AM
Finelli
C
C
Bondesan
A
A
Sani
G
G
D000818:Animals; D015237:Dinoprost / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D007247:Infertility, Female / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D007249:Inflammation; D008866:Microsurgery; D006080:Ovarian Follicle / Q000187:drug effects; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000139:chemically induced / Q000150:complications / Q000473:pathology; D014591:Uterine Diseases / Q000150:complications* / Q000209:etiology / Q000473:pathology; D014599:Uterus / Q000293:injuries / Q000601:surgery
D011453:Prostaglandins; D015237:Dinoprost; D015232:Dinoprostone
Il ruolo delle prostaglandine nella fertilità. Ricerca sperimentale.