title: The relationship between mood and sexuality in women using an oral contraceptive as a treatment for premenstrual symptoms.
abstract: This study investigated the effects of a triphasic oral contraceptive (OC) on mood and on sexual interest in a group of 45 women with premenstrual complaints. Subjects made daily ratings of mood and sexual interest for one baseline cycle and were then randomly assigned to receive either placebo or OC for 3 mo. Women who received the OC reported decreased sexual interest during the menstrual and postmenstrual phases of the cycle. The predominant effect of both the OC and the placebo on mood was one of improvement, particularly during the premenstrual phase. There was little evidence of co-variation of mood and sexual interest in either group. Although the mechanism for the adverse effects of the OC on levels of sexual interest in unknown, it is clear that this effect was not simply a consequence of pill-induced negative mood change. The findings provide evidence that mood and sexual desire are dissociable and suggest that OCs can have direct effects on women's sexuality.
authors.affiliation: MRC Reproductive Biology Unit, Royal Edinburgh Hospital, Scotland.
authors.forename: C A
authors.initials: CA
authors.lastname: Graham
authors.forename: B B
authors.initials: BB
authors.lastname: Sherwin
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects*; D003279:Contraceptives, Oral, Sequential / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007989:Libido / Q000187:drug effects*; D008597:Menstrual Cycle / Q000187:drug effects; D009640:Norethindrone / Q000008:administration & dosage / Q000009:adverse effects; D010555:Personality Inventory; D011293:Premenstrual Syndrome / Q000188:drug therapy* / Q000523:psychology
chemical_list: D003279:Contraceptives, Oral, Sequential; D004997:Ethinyl Estradiol; D009640:Norethindrone