High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain.
Trk-immunoreactivity was observed in basal forebrain and striatal cholinergic neurons, whereas low-affinity NGF receptor immunoreactivity was observed in basal forebrain but not striatal cholinergic neurons. Since NGF exerts trophic actions on both basal forebrain and striatal cholinergic populations, the presence of Trk in these neurons lends strong support for an essential role of Trk in NGF-responsive neurons, but suggests that the low affinity receptor is not necessary for NGF actions in the striatum.
Steininger
T L
TL
University of Chicago, IL 60637.
Wainer
B H
BH
Klein
R
R
Barbacid
M
M
Palfrey
H C
HC
D000818:Animals; D003342:Corpus Striatum / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000276:immunology / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D016548:Prosencephalon / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017475:Receptors, Nerve Growth Factor / Q000276:immunology / Q000378:metabolism*
D017475:Receptors, Nerve Growth Factor