Severe vascular toxicity associated with cisplatin-based chemotherapy.
A 19-year-old man with a germ cell tumor who experienced hypertension, acute myocardial infarction, and cerebrovascular accident (CVA) associated with hypomagnesemia as late complications of cisplatin-based chemotherapy is presented, and previously reported cases in the literature are reviewed. Different physiopathologic mechanisms are hypothesized for early and late vascular complications of cisplatin.
Içli
F
F
Department of Medicine, Ankara University, School of Medicine, Ibn-i Sina Hospital, Turkey.
Karaoğuz
H
H
Dinçol
D
D
Demirkazik
A
A
Günel
N
N
Karaoğuz
R
R
Uner
A
A
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000139:chemically induced*; D002561:Cerebrovascular Disorders / Q000139:chemically induced; D002945:Cisplatin / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008274:Magnesium / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced; D013724:Teratoma / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy
D008274:Magnesium; D002945:Cisplatin