Low-density lipoprotein immunofluorescence at the site of renal injury in glomerulosclerosis: a potential pathogenetic role for lipids in renal disease.
The role of lipids in the genesis of renal disease has received increased attention. We describe the presence of anti-low-density lipoprotein immunofluorescence at the site of renal injury found by light microscopy. This may offer immunohistologic evidence for a potential role of this atherogenic lipid in the genesis of renal disease and glomerulosclerosis. Furthermore, we describe the contribution of cholesterol in early renal disease and markers for malnutrition in the dialytic management of end-stage renal disease. Interventional strategies, including vasoactive agents present and future, are presented.
Avram
M M
MM
Division of Nephrology, Long Island College Hospital, Brooklyn, NY 11201.
D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008077:Lipoproteins, LDL / Q000032:analysis*; D008856:Microscopy, Fluorescence
D008077:Lipoproteins, LDL