title: Bloodstream infections in patients older than eighty years.
abstract: During a period of 3 years in a University Hospital in Israel, 339 episodes of bacteraemia were observed in patients 80 years of age or older, and 658 episodes in patients 60-79 years of age. Patients older than 80 were more often residents of nursing homes, frequently had a history of a cerebrovascular accident, but were less often neutropenic. Twenty-four per cent of bacteraemia episodes in the very old were hospital acquired compared with 40% in the old patients. The most common source of bacteraemia was the urinary tract, 50% of episodes in the very old, and 34% of episodes in the old. The percentage of episodes in which anaerobic bacteria were isolated was 5% in the very old and 1% in the old, and the difference was significant when corrected for the sources of bacteraemia. All cases of community-acquired bacterial endocarditis in patients of 80 or over were caused by pathogens originating from the gut. Thirty-five per cent of patients of 80 and over and 30% of patients aged 60-79 years died during hospitalization. Fatality was not associated with advanced age in the very old. Factors significantly and independently associated with fatality in both groups were a hospital-acquired infection, shock, low serum albumin, renal dysfunction and inappropriate antibiotic treatment.
authors.affiliation: Internal Medicine Department B, Beilinson Medical Centre, Petach Tiqva, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Leibovici
authors.forename: S D
authors.initials: SD
authors.lastname: Pitlik
authors.forename: H
authors.initials: H
authors.lastname: Konisberger
authors.forename: M
authors.initials: M
authors.lastname: Drucker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000382:microbiology / Q000401:mortality*; D001419:Bacteria / Q000302:isolation & purification; D001431:Bacteriological Techniques; D002423:Cause of Death; D003428:Cross Infection / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000401:mortality; D011446:Prospective Studies; D012307:Risk Factors; D012772:Shock, Septic / Q000382:microbiology / Q000401:mortality