title: A fungal phylogeny based upon orotidine 5'-monophosphate decarboxylase.
abstract: Orotidine 5'-monophosphate decarboxylase protein sequences from 14 fungi, 1 slime mold, 2 mammals, and 3 bacteria are compared and aligned and shown to be homologous. Based on the optimal alignment of the fungal sequences, a phylogenetic tree is derived. Within the fungi, the fission yeast Schizosaccharomyces pombe shows a closer relationship to both basidiomycetes and phycomycetes than it does to orthodox ascomycetes (plectomycetes, pyrenomycetes, and budding yeasts). Intron conservation shows a close relationship between phycomycetes and basidiomycetes. The imperfect fungi Trichoderma and Cephalosporium are shown to be closely related to Neurospora. The predicted origin of the group of budding yeasts is dependent on the analytical method used.
authors.affiliation: Department of Genetics, University of Leeds, UK.
authors.forename: A
authors.initials: A
authors.lastname: Radford
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D004275:DNA, Ribosomal / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics*; D005658:Fungi / Q000145:classification / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008322:Mammals / Q000235:genetics; D008969:Molecular Sequence Data; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000235:genetics*; D010802:Phylogeny; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software; D013045:Species Specificity
chemical_list: D001426:Bacterial Proteins; D004275:DNA, Ribosomal; D005656:Fungal Proteins; D012337:RNA, Ribosomal, 18S; D009964:Orotidine-5'-Phosphate Decarboxylase