The infusion of anti-RhO-(D) opsonized erythrocytes may be useful in the treatment of patients, splenectomized or not, with chronic, refractory autoimmune thrombocytopenic purpura--a prospective study.
Six patients with chronic refractory autoimmune thrombocytopenic purpura (ATP) were treated with five doses of autologous red blood cells (RBCs) opsonized ex vivo with anti-RhO-(D) IgG. Increases in platelet counts were observed in all cases; complete responses requiring no further treatment--for periods of 8-72 months--were recorded in four patients, three of them splenectomized. The cost of the procedure was significantly lower than other "Fc receptor (FcR) blockade" treatments.
Ruiz-Argüelles
G J
GJ
Centro de Hematología y Medicina Interna de Puebla, México.
Apreza-Molina
M G
MG
Pérez-Romano
B
B
Ruiz-Argüelles
A
A
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D016913:Blood Component Transfusion; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D013156:Splenectomy
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System