title: A lymph node interdigitating reticulum cell sarcoma.
abstract: A 20-year-old woman presented with bilateral cervical, supraclavicular, and mediastinal lymphadenopathy. A nodal biopsy specimen showed a diffuse malignant proliferation of large pleomorphic cells. The ultrastructural features and the antigen phenotype (expression of HLA-DR, CD68, alpha 1-antichymotrypsin, and S100 protein and inconstant reactivity for CD11c, CD15, and peanut agglutinin) were consistent with a derivation from interdigitating reticulum cells. Despite intensive combination chemotherapy with autologous bone marrow transplantation and local irradiation, the patient relapsed in the initial sites of the disease. A review of 12 previous reports of interdigitating reticulum cell sarcomas showed that most of these rare tumors behaved aggressively and were unresponsive to classic intensive chemotherapeutic regimens.
authors.affiliation: Centre Hospitalier Universitaire, Angers, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Rousselet
authors.forename: S
authors.initials: S
authors.lastname: François
authors.forename: A
authors.initials: A
authors.lastname: Croué
authors.forename: M
authors.initials: M
authors.lastname: Maigre
authors.forename: J P
authors.initials: JP
authors.lastname: Saint-André
authors.forename: N
authors.initials: N
authors.lastname: Ifrah
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008206:Lymphatic Diseases / Q000378:metabolism / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology*; D008854:Microscopy, Electron