PROBE: a computer program employing an integrated neural network approach to protein structure prediction.
A computer program, PROBE, has been designed for the prediction of protein structural features from amino acid sequence. This program integrates a variety of computer-simulated neural networks, each predicting an aspect of protein structure, into a single, easy-to-use package. The surface accessibility of each residue, the presence of disulfide bonds, the overall secondary structure composition and the residue secondary structures, including beta-turn type, are predicted. In addition, the overall amino acid composition and relative hydrophobicity are used to determine whether a protein belongs to one of four common folding motifs. PROBE is able to compare and synergistically improve the predictions by allowing communication between the different networks.
Holbrook
S R
SR
Structural Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Dubchak
I
I
Kim
S H
SH
D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D016571:Neural Networks, Computer; D017433:Protein Structure, Secondary; D012984:Software