title: Prehepatic portal hypertension in rats modifies norepinephrine metabolism in hypothalamus, medulla oblongata and portal vein.
abstract: The present experiments investigated the possible relationship between portal hypertension and norepinephrine metabolism in the central nervous system (hypothalamus and medulla oblongata) and the portal vein in the rat. Group I (72), portal hypertensive, and group II (70) sham-operated animals, were sacrificed day 14, and endogenous norepinephrine content, uptake and release from hypothalamus, medulla oblongata, and portal vein were investigated. In group I our results showed increases in norepinephrine storage (69%; 8.3%) and release (19.7%; 43.8%) and a diminished uptake (42.3%; 27.5%) in the hypothalamus and medulla oblongata, respectively. Portal veins showed a decreased content and uptake (62.5% and 43.5%, respectively) and increased release (25%) compared to group II rats. These results suggest a close relationship between the central nervous system and rat portal hypertension, perhaps related to modifications of central sympathetic activity.
authors.affiliation: Cátedra de Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Lemberg
authors.forename: F X
authors.initials: FX
authors.lastname: Eizayaga
authors.forename: M
authors.initials: M
authors.lastname: Vatta
authors.forename: A
authors.initials: A
authors.lastname: Dominguez
authors.forename: S
authors.initials: S
authors.lastname: Romay
authors.forename: L G
authors.initials: LG
authors.lastname: Bianciotti
authors.forename: G
authors.initials: G
authors.lastname: Sansó
authors.forename: B
authors.initials: B
authors.lastname: Fernández
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D004195:Disease Models, Animal; D006975:Hypertension, Portal / Q000209:etiology / Q000378:metabolism*; D007031:Hypothalamus / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000737:chemistry / Q000378:metabolism*; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism*; D011169:Portal Vein / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014316:Tritium
chemical_list: D014316:Tritium; D009638:Norepinephrine