Close proximity of the genes for leukemia inhibitory factor and oncostatin M.
Leukemia inhibitory factor (LIF) and oncostatin M (OSM) are structurally related cytokines that share a common receptor complex. The genes for LIF and OSM have previously been reported to be on human chromosome 22. We report here the isolation of a single 73 kbp human genomic yeast artificial chromosome clone that contains the LIF and OSM genes. The two genes lie within 19 kbp of each other and are transcribed in opposite directions.
Jeffery
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Immunex Research and Development Corporation, Seattle, WA 98101.
Price
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Gearing
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DP
D001483:Base Sequence; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D016521:Electrophoresis, Gel, Pulsed-Field; D006131:Growth Inhibitors / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000235:genetics*; D008969:Molecular Sequence Data; D053683:Oncostatin M; D010455:Peptides / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014158:Transcription, Genetic
D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; C508351:OSM protein, human; D010455:Peptides; D053683:Oncostatin M