title: Inhibition of prostanoid synthesis depresses alveolar bone resorption but enhances root resorption in the rat.
abstract: Tooth drift requires the deformation of the root socket and the adjustment of the other components of the attachment apparatus, namely, the periodontal ligament (PDL) and the cementum. Indomethacin (7.5 mg/kg/d), an inhibitor of prostanoid synthesis, provoked in rats a depression in the bone resorption effecting the deformation of the socket (Lasfargues and Saffar, Anat. Rec., 234:310-316, 1992). In the present paper we examined the consequence of this treatment both on the PDL and the root surface. After 3 days of treatment, when osteoclastic resorption was not yet disturbed, the root had been markedly resorbed (P < 0.05) opposite the resorbing bone surface; at that time the PDL width remained in the normal range. After 7 days, i.e., when the bone resorption was depressed, the PDL was widened as the result of the ongoing root resorption. Despite the extensive root resorption, the anchorage of the PDL fibers appeared to remain effective, suggesting that it was rapidly restored. On day 14 at the time of the bone resorption recovery, cementum was deposited in the root resorption lacunae and the PDL width had returned to its control value. As early as day 3 the daily rate of dentine formation increased in the pulp area subjacent to the root resorption lacunae (P < 0.01). These data demonstrate that i) the responses of the different components of the periodontal apparatus are coordinated to allow for the maintainance of the PDL width so that when bone resorption is disturbed, root resorption compensates for it, and ii) the odontoclasts can differentiate and resorb under prostanoid inhibition whilst osteoclastic resorption of the bone socket is inhibited.
authors.affiliation: Laboratoire de Biologie et Biomateriaux, du Milieu Buccal et Osseux, Faculté de Chirurgie Dentaire, Université Paris-V, Montrouge, France.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lasfargues
authors.forename: J L
authors.initials: JL
authors.lastname: Saffar
mesh_terms: D000222:Adaptation, Physiological; D016301:Alveolar Bone Loss / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D003739:Dental Cementum / Q000473:pathology / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010010:Osteoclasts / Q000473:pathology; D010513:Periodontal Ligament / Q000473:pathology / Q000503:physiopathology; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D014085:Tooth Migration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
chemical_list: D011453:Prostaglandins; D007213:Indomethacin