Role of cephalosporinase in carbapenem resistance of clinical isolates of Pseudomonas aeruginosa.
With numerous imipenem-resistant clinical isolates of Pseudomonas aeruginosa as well as in vitro-selected resistant mutants, we have demonstrated, by a simple method with a powerful cephalosporinase inhibitor, BRL42715, the contribution of chromosomal cephalosporinase in resistance to imipenem in this species.
Zhou
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Laboratoire de Microbiologie Médicale, Université Paris VI, France.
Kitzis
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MD
Gutmann
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000378:metabolism / Q000494:pharmacology*; D002510:Cephalosporinase / Q000378:metabolism / Q000502:physiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D006868:Hydrolysis; D015378:Imipenem / Q000494:pharmacology; D007769:Lactams; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology*; D013845:Thienamycins / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007769:Lactams; D013845:Thienamycins; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; C061593:C6-(N1-methyl-1,2,3-trazolylmethylene)penem; D015378:Imipenem; D002510:Cephalosporinase; D000077731:Meropenem