Fibrocalculous pancreatic diabetes in Pune, India. Clinical features and follow-up for 7 yr.
OBJECTIVE
To study clinical features of fibrocalculous pancreatic diabetes from this clinic, to compare these with the published criteria of malnutrition-related diabetes mellitus, and to conduct serial follow-up of these patients to study difficulties in their treatment.


METHODS
Details of presenting symptoms, anthropometry, diabetic tissue damage, treatment, and follow-up of 55 patients with fibrocalculous pancreatic diabetes (pancreatic calculi demonstrated on X-ray and sonography) treated during the last 7 yr were studied.


RESULTS
Many patients did not fit the accepted criteria of malnutrition-related diabetes. Thus, 17 (31%) were diagnosed after 30 yr of age and 23 (42%) had a body mass index > 18 kg/m2, and the daily dose of insulin in these patients (mean 0.8 U/kg) was similar to that in the IDDM patients (mean 1.0 U/kg). The two pathognomonic complaints (pancreatic pain and steatorrhea) were not always present. Many patients took very irregular treatment, but none suffered diabetic ketoacidosis despite stopping insulin for long periods of time; 33% of patients had some diabetic tissue damage when first seen. Fourteen patients were lost to follow-up, and 11 died during the follow-up.


CONCLUSIONS
Clinical features of these fibrocalculous pancreatic diabetes patients were somewhat different than the classic descriptions. A need exists to reconsider classification of FCPD under malnutrition-related diabetes mellitus. Many patients receive irregular treatment, and a substantial proportion die within a few years of diagnosis, many as a result of preventable causes.
Yajnik
C S
CS
Wellcome Diabetes Study, King Edward Memorial Hospital, Pune, India.
Shelgikar
K M
KM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002100:Cachexia / Q000209:etiology; D002114:Calcinosis / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000097:blood / Q000209:etiology* / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003927:Diet, Diabetic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009748:Nutrition Disorders / Q000209:etiology; D009765:Obesity; D010195:Pancreatitis / Q000097:blood / Q000150:complications* / Q000503:physiopathology
D001786:Blood Glucose