Intraventricular alpha interferon therapy for Rasmussen's syndrome.
A 4-year-old boy developed Rasmussen's syndrome and was treated with alpha interferon intraventricularly. An improvement in the epileptic and neurologic syndrome was noted for several weeks following interferon. No adverse side effects were encountered. Since hemispherectomy is the only established therapy in Rasmussen's Syndrome, further studies are needed to establish if intraventricular alpha interferon may halt the clinical progression of the syndrome.
Maria
B L
BL
Division of Pediatric Neurology, University of Florida College of Medicine, Gainesville 32610-0296.
Ringdahl
D M
DM
Mickle
J P
JP
Smith
L J
LJ
Reuman
P D
PD
Gilmore
R L
RL
Drane
W E
WE
Quisling
R G
RG
D001284:Atrophy / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007276:Injections, Intraventricular; D007370:Interferon Type I / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D011994:Recombinant Proteins; D013577:Syndrome; D015899:Tomography, Emission-Computed, Single-Photon
D007370:Interferon Type I; D011994:Recombinant Proteins