[Anti-oxidative effects of R8605, a third-generation retinoid].
The anti-oxidative effects of R8605, a compound of the third generation retinoids, have been studied. R8605 exhibited pronounced inhibitory effects on FeSO4/cysteine and NADPH/vitamin C-induced lipid peroxidation of rat liver microsome as well as on H2O2-induced lipid peroxidation of erythrocytes: Their IC50's were 9.8, 17.6 and 20.3 mumol/L, respectively. R8605 decreased the generation of superoxide anion (O2-.) in a xanthine/xanthine oxidase system and also elevated hepatic superoxide dismutase (SOD) activity in mice. Therefore R8605 shows potent antioxidative effects and this is likely of importance in its chemopreventive actions.
Sun
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Institute of Materia Medica, Beijing.
Han
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D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012176:Retinoids / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D012176:Retinoids; C073874:R 8605; D013482:Superoxide Dismutase