Enhancement of histamine-induced vascular leakage by pertussis toxin in SJL/J mice but not BALB/c mice.
Pertussis toxin (PTX) from Bordetella pertussis is known to enhance inflammatory responses which involve histamine and serotonin, including cell-mediated delayed-type hypersensitivity reactions. In this study we examined the effects of PTX on histamine-modulated microvascular responses. The actions of histamine on arteriole diameter and post-capillary leaky site formation in the cremaster muscle were measured intra-vitally in two inbred strains of mice (viz. BALB/c and SLJ). In SJL mice the rate and extent of histamine-induced leaky site formation were greatly enhanced (from 8.3 to 21.0 leaky sites per 0.1 cm2) by pre-exposure to PTX. In sharp contrast, PTX did not alter histamine-induced leaky site formation in BALB/c mice. Histamine-mediated dilation in arterioles in both strains of mice were not enhanced by PTX. PTX may enhance the development of inflammatory responses by enhancing histamine-induced leaky site formation of the microvasculature.
Yong
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Department of Medical Physiology, College of Medicine, Texas A & M University College Station 77843-4467.
Meininger
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GA
Linthicum
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DS
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects*; D004357:Drug Synergism; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000502:physiology*; D008815:Mice, Inbred Strains / Q000502:physiology*; D008833:Microcirculation / Q000187:drug effects; D037342:Pertussis Toxin; D012016:Reference Values; D014664:Vasodilation / Q000187:drug effects; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D010566:Virulence Factors, Bordetella; D006632:Histamine; D037342:Pertussis Toxin