Mental and behavioural deterioration of children with epilepsy and CSWS: acquired epileptic frontal syndrome.
Four children with 'epilepsy and continuous spike-wave sleep' syndrome and mental and behavioural regression were followed prospectively with neuropsychological tests, behavioural questionnaires and sleep EEG performed at regular intervals between 1 1/2 and four years of age. The children showed a pattern of behavioural and cognitive disturbances similar to that found in some developmental autistic-like disorders, but also in adult frontal syndrome. Deterioration was probably due to an unusual long-standing epileptic dysfunction involving the frontal lobes. The process is potentially reversible and seems to be the same as postulated for acquired epileptic aphasia, but in a different localization.
Roulet Perez
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Service de Pédiatrie, CHUV, Lausanne, Switzerland.
Davidoff
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Despland
P A
PA
Deonna
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T
D001921:Brain / Q000503:physiopathology*; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005013:Ethosuximide / Q000008:administration & dosage / Q000627:therapeutic use; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012890:Sleep / Q000502:physiology*
D005013:Ethosuximide