Chromosomal localization of omega and trophoblast interferon genes in goat and sheep by fluorescent in situ hybridization.
Fluorescent in situ hybridization (FISH) of the cattle cDNA probe bTP-509 to goat (Capra hircus L.) and sheep (Ovis aries L.) R-banded metaphase chromosomes localized the omega (IFNW) and trophoblast (IFNT) interferon genes to goat chromosome 8q15 and sheep chromosome 2p15. Caprine chromosome 8 and ovine chromosome 2p are equivalent in banding pattern to cattle chromosome 8. Since FISH has previously localized IFNW and IFNT genes to cattle chromosome 8q15 and river buffalo 3q15, the localization of IFNW and IFNT genes in goat and sheep provides evidence in support of the hypothesis that chromosome-banding homology among these four species is indicative of underlying genetic homology.
Iannuzzi
L
L
National Research Council, Naples, Italy.
Di Meo
G P
GP
Gallagher
D S
DS
Ryan
A M
AM
Ferrara
L
L
Womack
J E
JE
D000818:Animals; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D006041:Goats / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D007370:Interferon Type I / Q000235:genetics*; D005810:Multigene Family; D012756:Sheep / Q000235:genetics*; D014327:Trophoblasts
D007370:Interferon Type I