Gliosarcoma with features of chondroblastic osteosarcoma.
BACKGROUND
The occurrence of osteoid-chondral elements in gliosarcoma is extremely rare and has been reported in only two cases. A new, rare case of gliosarcoma with osteosarcomatous differentiation in a 55-year-old man and histogenesis of osteoid-chondral tissue in gliosarcoma is discussed.


METHODS
Surgically removed tumor tissues were examined immunohistochemically and electron microscopically, and a histologic examination was performed.


RESULTS
Immunohistochemical and electron microscopic studies confirmed the presence of glial, fibroblastic, and osteoid-chondral elements. A major part of the sarcomatous tissue was undifferentiated and stained only by vimentin. Some areas of osteoid-chondral tissue were positive for glial fibrillary acidic protein (GFAP).


CONCLUSIONS
These data suggest that osteoid-chondral elements came from the sarcomatous portion and GFAP positivity is not restricted to astrocytes and has been seen particularly in chondroid areas of non-glial tumors.
Hayashi
K
K
Second Department of Pathology, Okayama University Medical School, Japan.
Ohara
N
N
Jeon
H J
HJ
Akagi
S
S
Takahashi
K
K
Akagi
T
T
Namba
S
S
D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic; D002804:Chondroblastoma / Q000737:chemistry / Q000473:pathology*; D005625:Frontal Lobe / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005910:Glioma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000737:chemistry / Q000473:pathology*
D005904:Glial Fibrillary Acidic Protein