title: 'Patchwork' fields in thermoradiotherapy for extensive chest wall recurrences of breast carcinoma.
abstract: Chest wall lesions of advanced breast carcinoma in 23 patients were treated with thermoradiotherapy with clinical intent between January 1987 and March 1992. Treatment consisted of external 915 MHz microwave hyperthermia with commercially available applicators and radiation therapy to doses between 32-58 Gy. Twenty-three large, diffuse lesions were treated with multiple field patchwork hyperthermia. All lesions were diffuse with or without multiple nodules < or = 3 cm depth. All lesions had failed previous therapy. The mean number of hyperthermia fields per patient was 3.2 +/- 0.4 (range of 2-7). The complete response rate was 91% in this group of extensive, diffuse lesions treated by the patchwork technique. Mean total radiation dose administered concurrently with multiple field patchwork hyperthermia was 42 +/- 1 Gy. The recurrence rate was 5%. The mean survival in patients who had a complete response was 9.0 +/- 1.3 months. The reduced survival among patchwork treated patients was due to the extensive tumor burden existing outside of the treated fields in these patients. The skin reactions were minor, causing minimal discomfort. There was no evidence of increased thermal damage to skin, or of tumor recurrence at junctions of hyperthermia field overlap. It is concluded that extensive, diffuse lesions of chest wall recurrence of advanced carcinoma of the breast can be treated effectively with multiple field patchwork thermotherapy.
authors.affiliation: Department of Radiation Oncology & Nuclear Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
authors.forename: K
authors.initials: K
authors.lastname: Engin
authors.forename: L
authors.initials: L
authors.lastname: Tupchong
authors.forename: F M
authors.initials: FM
authors.lastname: Waterman
authors.forename: L
authors.initials: L
authors.lastname: Komarnicky
authors.forename: C M
authors.initials: CM
authors.lastname: Mansfield
authors.forename: D B
authors.initials: DB
authors.lastname: Leeper
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000628:therapy*