The influence of delayed renal allograft function on long-term outcome in the cyclosporine era.
The influence of delayed renal graft function on long-term allograft outcome remains uncertain. All 495 cyclosporine treated cadaver donor renal transplants within a single center were analyzed with respect to dialysis dependence in the early posttransplant period. When compared with immediate allograft function, dialysis dependence for more than one week posttransplant was associated with prolonged cold ischemia time (27 +/- 11 vs 32 +/- 12 hours), cytotoxic antibodies > 30% (14% vs 25%), black race (29% vs 41%), increased incidence of acute rejection in the first year posttransplant (31% vs 67%) and inferior 1-year (85% vs 52%) and 5-year (68% vs 33%) graft survival among primary transplants. No adverse effect however was noted on renal function in long-term survivors.
Cacciarelli
T
T
Department of Medicine, State University of New York Health Science Center, Brooklyn.
Sumrani
N
N
Delaney
V
V
Hong
J H
JH
DiBenedetto
A
A
Sommer
B G
BG
D000328:Adult; D001741:Black or African American; D002102:Cadaver; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007165:Immunosuppression Therapy; D015994:Incidence; D016030:Kidney Transplantation / Q000502:physiology* / Q000706:statistics & numerical data; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D006435:Renal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
D016572:Cyclosporine; D011241:Prednisone