Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line.
The role of T lymphocytes in disseminated candidiasis in a mouse model of irradiation-induced immunosuppression was investigated. A continuously cultured Candida albicans-specific T-cell line mediated protection of sublethally irradiated mice from disseminated candidiasis as measured by both the fungal load in the kidneys and mortality. These results are the first to demonstrate directly a role for antigen-specific T cells in the protective immune response against murine disseminated candidiasis.
Sieck
T G
TG
Department of Pathology and Laboratory Medicine, Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102.
Moors
M A
MA
Buckley
H R
HR
Blank
K J
KJ
D000818:Animals; D002177:Candidiasis / Q000276:immunology*; D002460:Cell Line; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*