Suggestion of linkage between manic-depressive illness and the enzyme phosphoglycolate phosphatase (PGP) on chromosome 16p.
Two large Danish pedigrees with manic-depressive illness (MDI) were ascertained through bipolar probands. The pedigrees include bipolar as well as unipolar cases. An autosomal dominant mode of inheritance with incomplete penetrance was assumed. Linkage relationships between MDI and 37 autosomal serum, enzyme and blood group markers were investigated. For phosphoglycolate phosphatase, a maximum lod score of 2.20 at 0% recombination was found for the largest family. The other family was not informative. This may suggest assignment of a major gene for MDI to chromosome 16p13.
Eiberg
H
H
University Institute of Medical Biochemistry & Genetics, Danish Centre for Human Genome Research, Copenhagen.
Ewald
H
H
Mors
O
O
D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*
D005819:Genetic Markers; C022408:phosphoglycolate phosphatase; D010744:Phosphoric Monoester Hydrolases