[The interventricular functional-morphological correlations in chronic overloading of the primarily intact left heart in a model of experimental vasorenal hypertension].
This investigation shows the work of the heart as an integral functional system where each of the ventricles plays its own vital role, especially in the case where only one ventricle is pathologically affected. Moreover, the changes in the right heart have been carefully studied, thus showing its immediate involvement in cases of left heart hemodynamical overloading. The experiment was carried out on 178 mature rabbits with a model of vasorenal arterial hypertension based upon coarctation of the abdominal aorta just above the renal arteries. Arterial and intraventricular parameters of blood pressure were registered and morphological investigation involved transmission electron microscopy of the left and right ventricular myocardia, especially paying attention to mitochondrial changes in the cardiomyocytes. The right ventricle reacts at the same time as the left ventricle, although it shows a more intensive function and reaches decompensation earlier than the left heart.
Ramdavon
P
P
Drozdova
G A
GA
Bakhilov
V L
VL
Frolov
V A
VA
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology / Q000648:ultrastructure; D006439:Hemodynamics; D006978:Hypertension, Renovascular / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D010210:Papillary Muscles / Q000648:ultrastructure; D011817:Rabbits; D013997:Time Factors
Mezhzheludochkovye funktsional'no-morfologicheskie vzaimootnosheniia pri khronicheskoĭ peregruzke pervichno intaktnogo levogo otdela serdtsa na modeli éksperimental'noĭ vazorenal'noĭ gipertenzii.