title: Immunohistochemical distribution of S-100 alpha-positive cells in bovine mycobacterial and non-mycobacterial granulomas.
abstract: By means of immunohistochemistry, the distribution of the alpha-subunit (S-100 alpha) and the beta-subunit (S-100 beta) of S-100 protein was studied in bovine granulomas caused by Actinomyces bovis, Actinobacillus lignieresi, Actinomyces (Corynebacterium) pyogenes, Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium bovis and Mycobacterium paratuberculosis. S-100 alpha-positive epithelioid cells or dendritic cells were scattered among the predominantly S-100 alpha-negative cells of the mononuclear phagocyte system (MPS). S-100 beta was not found in the MPS cells of granulomas but was observed in the endothelial cells of blood vessels. A positive reaction to S-100 was also seen in normal cells in the lymphoid and mammary tissues. Mycobacterial granulomas contained more S-100 alpha-positive cells than did non-mycobacterial ones.
authors.affiliation: National Institute of Animal Health, Tsukuba, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Momotani
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsubara
authors.forename: Y
authors.initials: Y
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Yoshino
mesh_terms: D000818:Animals; D015415:Biomarkers; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology; D006099:Granuloma / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D009164:Mycobacterium Infections / Q000473:pathology / Q000662:veterinary*; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis*
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; C030564:S-100 calcium-binding protein alpha subunit; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins