[A quantitative pharmaco-electroencephalographic analysis of the action of bromantane].
The action of the new stimulant bromantane on spectra power EEG on Fourier of sensorimotor cortex, dorsal hippocamp and lateral hypothalamus of left and right hemispheres of brain of rat in free behavior was investigated. Bromantane leads to decreases in the total and absolute powers of all frequency bands of EEG spectra, changes structural spectra in the cortex and in hippocamp--decreases the relative power of theta-band and increases the relative power of beta 1, 2-activity. The basic feature of bromantane's action is a two-phase effect (its maximum occurs 2-3 and 6-7 hours after administration), which remains up to 8 h of EEG recording. These data suggest that that bromantane has more marked and prolonged stimulant properties than other adamantane psychostimulants.
Krapivin
S V
SV
Sergeeva
S A
SA
Morozov
I S
IS
D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects* / Q000706:statistics & numerical data; D005583:Fourier Analysis; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
D011619:Psychotropic Drugs; C070094:2-aminoadamantane; D000547:Amantadine; C085955:bromantane
Kolichestvennyĭ farmako-élektroéntsefalograficheskiĭ analiz deĭstviia bromantana.