Polycystic ovarian syndrome. Evidence for an autoimmune mechanism in some cases.
Antiovarian autoantibodies localized to the granulosa cells were detected in 50% of a group of eight patients diagnosed with polycystic ovarian syndrome. An analogy is drawn to other endocrinopathies characterized by hypersecretion of hormones, notably thyroid and adrenal, and a pathogenetic mechanism involving stimulating antibody is postulated.
van Gelderen
C J
CJ
Department of Obstetrics and Gynaecology, Baragwanath Hospital, Johannesburg, South Africa.
Gomes dos Santos
M L
ML
D000328:Adult; D001323:Autoantibodies / Q000378:metabolism*; D005260:Female; D006107:Granulosa Cells / Q000276:immunology; D006801:Humans; D010053:Ovary / Q000276:immunology; D011085:Polycystic Ovary Syndrome / Q000276:immunology*
D001323:Autoantibodies