The influence of ileal pouch-anal anastomosis for ulcerative colitis on ileal glycoprotein synthesis.
Restorative proctocolectomy and ileal pouch-anal anastomosis are frequently associated with the onset of low-grade inflammation, colonic metaplasia, and pouchitis. The influence of intestinal adaptation and inflammatory activity on ileal glycoprotein synthesis (GS) has been assessed. Ileal GS activity in controls (n = 13, 28.9 +/- 3.6) was similar to that of patients with ulcerative colitis (n = 18, 26.4 +/- 3.6) irrespective of the presence of backwash ileitis (n = 6, 22.0 +/- 4.0). Ileoanal pouch construction was not associated with a significant change in ileal GS activity regardless of the presence of low-grade inflammation (n = 19, 25.9 +/- 2.2), frank pouchitis (n = 5, 24.4 +/- 4.6), or transformation to a colonic type of mucosa (n = 6, 25.4 +/- 5.2). The transformation of ileal mucosa from an absorptive to a storage function is associated with characteristic morphologic and inflammatory changes but does not produce a protective response mediated by increased GS.
Winslet
M C
MC
Academic Dept. of Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, U.K.
Poxon
V
V
Allan
A
A
Keighley
M
M
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D003093:Colitis, Ulcerative / Q000378:metabolism / Q000601:surgery*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism*; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D007079:Ileitis / Q000209:etiology* / Q000378:metabolism; D007082:Ileum / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D008875:Middle Aged; D016737:Proctocolectomy, Restorative
D006023:Glycoproteins; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)