title: Regression of metastatic renal cell carcinoma after cytoreductive nephrectomy.
abstract: Fewer than 1% of patients with renal cell carcinoma are reported to experience spontaneous regression of metastatic lesions after nephrectomy. We report on 4 of 91 patients (4.4%) with metastatic renal cell carcinoma who had spontaneous regression of all metastatic lesions after cytoreductive nephrectomy. These patients were carefully selected before surgery for the ability to receive high dose interleukin-2. One patient had recurrence at 2 months, 1 had recurrence at 11 months, and 2 had no evidence of disease at 3 and 4.5 years.
authors.affiliation: Surgery Branch, National Cancer Institute, Bethesda, Maryland.
authors.forename: S G
authors.initials: SG
authors.lastname: Marcus
authors.forename: P L
authors.initials: PL
authors.lastname: Choyke
authors.forename: R
authors.initials: R
authors.lastname: Reiter
authors.forename: G S
authors.initials: GS
authors.lastname: Jaffe
authors.forename: R B
authors.initials: RB
authors.lastname: Alexander
authors.forename: W M
authors.initials: WM
authors.lastname: Linehan
authors.forename: S A
authors.initials: SA
authors.lastname: Rosenberg
authors.forename: M M
authors.initials: MM
authors.lastname: Walther
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D009392:Nephrectomy