title: Prospective comparative study of technetium-99m-WBCs and indium-111-granulocytes for the examination of patients with inflammatory bowel disease.
abstract: In a prospective comparative study of 14 patients with inflammatory bowel disease (IBD), the abilities of 99mTc-HMPAO labeled white blood cells (WBCs) and 111In-granulocytes to assess the presence and location of active disease were compared. The two examinations were carried out within 2 wk of each other. Scintigraphically concordant positive or discordant segments were evaluated by radiologic or endoscopic examination performed within 14 days. When bowel segments were compared, concordance was found for 102/111 (91.8%) segments between 99mTc-WBC images obtained at 1 hr after injection and 3-hr 111In-granulocyte images. For five of five 99mTc-WBCs positive/111In-granulocyte negative segments, it could be proven that the 99mTc-WBC result was caused by active disease. For patients, 99mTc-WBC scintigraphy detected four more patients with active disease than 111In-granulocytes (11 and 7 patients, respectively). Technetium-WBCs was superior in the assessment of active disease, especially for small bowel segments. We conclude that early imaging 1 hr after the injection of 99mTc-WBCs can reliably replace 111In-granulocyte scintigraphy in IBD patients because the radiopharmaceutical is available on a daily basis. Thus, there is less radiation burden to the patient and cell separation is simpler and less time-consuming.
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, University Hospital, Leiden, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Arndt
authors.forename: A
authors.initials: A
authors.lastname: van der Sluys Veer
authors.forename: D
authors.initials: D
authors.lastname: Blok
authors.forename: G
authors.initials: G
authors.lastname: Griffoen
authors.forename: H W
authors.initials: HW
authors.lastname: Verspaget
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003424:Crohn Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006098:Granulocytes; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes; D008297:Male; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010091:Oximes; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D014334:Tropolone / Q000031:analogs & derivatives
chemical_list: D007205:Indium Radioisotopes; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010091:Oximes; C043895:indium tris(tropolonate); D019690:Technetium Tc 99m Exametazime; D014334:Tropolone