title: [Adrenal cortex function in children with bronchial asthma in fluticasone therapy].
abstract: In order to study the adverse reaction of a new, inhaled steroid (Fluticasone) on the pituitary-adrenocortical axis in asthmatic children, we investigated 7 children (aged 7 to 15 years) before and during treatment with Fluticason (100-200 micrograms/day). For the dosage tested, we found no depression of adrenal function, neither in circadian cortisol secretion nor in hCRH-stimulation-test. Another 7 asthmatic children under treatment with Budesonide (800 micrograms/day) were examined by the same tests. They equally did not show an adrenocortical suppression. However, in 4 other children under therapy with oral prednisone (2.5 to 7.5 mg/day), there was a marked suppression on adrenocortical function, even with low doses of the steroid. We conclude that Fluticasone (as well as Budesonide) in the above dosages represent a safe therapy for bronchial asthma in children.
authors.affiliation: Universitäts-Kinderklinik (KAVH), Berlin.
authors.forename: A
authors.initials: A
authors.lastname: Hoffmann-Streb
authors.forename: D
authors.initials: D
authors.lastname: L'Allemand
authors.forename: B
authors.initials: B
authors.lastname: Niggemann
authors.forename: P
authors.initials: P
authors.lastname: Büttner
authors.forename: U
authors.initials: U
authors.lastname: Wahn
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects*; D000730:Androstadienes / Q000008:administration & dosage* / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects; D019819:Budesonide; D002648:Child; D003346:Corticotropin-Releasing Hormone; D005260:Female; D000068298:Fluticasone; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D011282:Pregnenediones / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D011282:Pregnenediones; D019819:Budesonide; D003346:Corticotropin-Releasing Hormone; D011239:Prednisolone; D000068298:Fluticasone; D006854:Hydrocortisone
vernacular_title: Nebennierenrindenfunktion bei Kindern mit Asthma bronchiale unter Therapie mit Fluticason.