High-dose chlorambucil and dexamethasone for relapsed non-Hodgkin's lymphomas.
Twenty patients with relapsed or refractory non-Hodgkin's lymphoma were treated with high-dose chlorambucil (14 mg/m2 every 6 hours for 6 doses) and dexamethasone (40 mg/day for 5 days). There was a 45% response rate with 17% complete responses. The median duration of complete response was 7 months. The regimen was well tolerated and had minimal toxicity.
Joseph
G
G
Division of Medical Oncology, University of Louisville School of Medicine, Kentucky.
Hadley
T
T
Djulbegovic
B
B
Hamm
J
J
Seeger
J
J
Blumenreich
M
M
Woodcock
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002699:Chlorambucil / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction
D002699:Chlorambucil; D003907:Dexamethasone