[The membrane-protective effect of carnosine in the post-resuscitation period after acute lethal blood loss].
Activation of serum enzymes in male rats was detected during the postresuscitation period after 4-6-min clinical death as a result of membrane destruction. Increase in the rate of lipid peroxidation and impairments of energy metabolism in the myocardium were responsible for destruction of cardiomyocyte biomembranes. Administration of carnosine (25 mg/kg body weight) simultaneously with compensation for blood loss obviated the membrane lipid bilayer destruction and contributed to the development of the optimal conditions for membrane-bound enzymes.
Rusakov
V V
VV
Dolgikh
V T
VT
Korpacheva
O V
OV
D000818:Animals; D002336:Carnosine / Q000494:pharmacology / Q000627:therapeutic use*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004734:Energy Metabolism; D004789:Enzyme Activation; D006321:Heart / Q000503:physiopathology; D006470:Hemorrhage / Q000188:drug therapy* / Q000401:mortality; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D012151:Resuscitation
D002336:Carnosine
Membranoprotektornoe deĭstvie karnozina v postreanimatsionnom periode posle ostroĭ smertel'noĭ krovopoteri.