title: Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.
abstract: Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using monoclonal antibodies, IL-1 prolonged the in vitro survival of polymorphonuclear cells (PMN) through IL-1R I, and IL-4 antagonized the action of IL-1 by inducing expression and release of IL-1R II. Dexamethasone also induced expression and release of the IL-1R II in PMN. These results, together with the effect of antibodies to IL-1R on IL-1-induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1. The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action.
authors.affiliation: Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Colotta
authors.forename: F
authors.initials: F
authors.lastname: Re
authors.forename: M
authors.initials: M
authors.lastname: Muzio
authors.forename: R
authors.initials: R
authors.lastname: Bertini
authors.forename: N
authors.initials: N
authors.lastname: Polentarutti
authors.forename: M
authors.initials: M
authors.lastname: Sironi
authors.forename: J G
authors.initials: JG
authors.lastname: Giri
authors.forename: S K
authors.initials: SK
authors.lastname: Dower
authors.forename: J E
authors.initials: JE
authors.lastname: Sims
authors.forename: A
authors.initials: A
authors.lastname: Mantovani
mesh_terms: D000911:Antibodies, Monoclonal; D002470:Cell Survival / Q000276:immunology; D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000502:physiology*; D015847:Interleukin-4 / Q000502:physiology*; D008970:Molecular Weight; D009000:Monocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D017472:Receptors, Interleukin-1 / Q000145:classification / Q000187:drug effects / Q000502:physiology*
chemical_list: D000911:Antibodies, Monoclonal; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D015847:Interleukin-4; D003907:Dexamethasone