Echo-planar MR imaging of human brain oxygenation changes.
Echo-planar magnetic resonance (MR) imaging was used to observe signal intensity changes in the human brain during hypoxia. Increasing arterial blood levels of deoxyhemoglobin (0%-42%) during prolonged apnea were monitored with a pulse oximeter and correlated with gray matter and white matter signal attenuation of 13% and 20%, respectively. The results suggest the possibility of using deoxyhemoglobin boluses as a physiologic, intravascular susceptibility contrast agent for assessment of local cerebral oxygen utilization.
Stehling
M K
MK
Department of Neurosurgery, University of Erlangen, Germany.
Schmitt
F
F
Ladebeck
R
R
D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D000860:Hypoxia / Q000097:blood; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption
D006454:Hemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen