title: Amino acids and peptides. XVIII. Synthetic peptides related to N-terminal portion of fibrin alpha-chain and their inhibitory effect on fibrinogen/thrombin clotting.
abstract: Peptide analogs of the N-terminal portion of fibrin alpha-chain were prepared and their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, H-Gly-Pro-Arg-Pro-Pro-NH2 exhibited the most potent inhibitory effect.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawasaki
authors.forename: M
authors.initials: M
authors.lastname: Miyano
authors.forename: K
authors.initials: K
authors.lastname: Hirase
authors.forename: M
authors.initials: M
authors.lastname: Iwamoto
mesh_terms: D000595:Amino Acid Sequence; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology*; D005337:Fibrin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005340:Fibrinogen / Q000037:antagonists & inhibitors; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D009842:Oligopeptides; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin