title: [A meta-analytical review of the response by sex to vaccination against hepatitis B in hospital personnel].
abstract: OBJECTIVE
  To study the influence of gender on the immunogenic response to the hepatitis B vaccine in healthy persons.
  
  
  METHODS
  Meta-analysis.
  
  
  METHODS
  Primary care: prevention.
  
  
  METHODS
  The results published between 1983 and 1991 by several authors dealing with staff in Spanish hospitals were reviewed.
  
  
  RESULTS
  It was observed that the frequency of women's antibody response differed significantly from that of men (chi-squared = 23.35; p < 0.001) with an odds ratio of 2 (95% confidence intervals: 1.64-2.46) and a risk difference of 7.69% (95% CI: 5.2-10.19%).
  
  
  CONCLUSIONS
  The response rate to the hepatitis B vaccine is significantly higher among women than men. However, several factors (e.g. age and weight) may affect these findings. These have not been examined because they were not described in the findings of the preliminary studies.
authors.affiliation: Hospital Universitario del Aire, Universidad Complutense de Madrid.
authors.forename: J M
authors.initials: JM
authors.lastname: Morales
authors.forename: J
authors.initials: J
authors.lastname: Jaqueti
authors.forename: C
authors.initials: C
authors.lastname: Viña
mesh_terms: D016009:Chi-Square Distribution; D016001:Confidence Intervals; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D008297:Male; D008505:Medical Staff, Hospital / Q000706:statistics & numerical data; D012307:Risk Factors; D012727:Sex Characteristics; D013030:Spain / Q000453:epidemiology
chemical_list: D017325:Hepatitis B Vaccines
vernacular_title: Revisión metaanalítica de la respuesta por sexo a la vacunación contra la hepatitis B en personal hospitalario.