Inactivation of rifampin by Nocardia brasiliensis.
Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.
Yazawa
K
K
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Mikami
Y
Y
Maeda
A
A
Akao
M
M
Morisaki
N
N
Iwasaki
S
S
D006031:Glycosylation; D008658:Inactivation, Metabolic; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects / Q000378:metabolism*; D012293:Rifampin / Q000378:metabolism / Q000493:pharmacokinetics*
D012293:Rifampin