title: Synaptic remodelling and elimination as integral processes of synaptogenesis.
abstract: It has become increasingly clear that the development and maintenance of synaptic connectivity patterns in the central and peripheral nervous system are not only based on the formation of synapses but include the selective elimination of synaptic subpopulations. Synaptic remodeling and elimination apparently also play a key role in the specification of neuronal connections during ontogenesis of the neocortex in various species. At least three types of synapse elimination have been demonstrated until now, i.e. physiological cell death of synaptically connected neurons, synaptic disconnection and lysosomal degradation, predominantly of presynaptic elements. Occurrence of different elimination types appears to depend on (1) whether the presynaptic or postsynaptic element induces the synaptic reorganization and (2) whether or not the neuron inducing the synapse elimination survives. The same type of synapse elimination may be seen during normal development and under pathological conditions. Factors inducing mental retardation may then either retard synapse formation or interfere with the process of synapse removal. In order to undergo plastic changes in synaptic connections, neurons may respond to exogenous factors such as lack of trophic factors or sensitivity for them (e.g. NGF), long-lasting changes in neuronal activity (e.g. due to drug application or sensory deprivation), hormonal influences (e.g. thyroxin or sexual hormones), learning conditions, or lesions (partial deafferentation and axotomy). The neurons, in turn, may change their responsiveness to exogenous stimuli by inducing synaptic reorganisation.
authors.affiliation: Department of Anatomy, University of Göttingen, Germany.
authors.forename: J R
authors.initials: JR
authors.lastname: Wolff
authors.forename: M
authors.initials: M
authors.lastname: Missler
mesh_terms: D000367:Age Factors; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D003712:Dendrites / Q000648:ultrastructure; D006801:Humans; D009024:Morphogenesis; D009473:Neuronal Plasticity; D011323:Primates; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure*