UV-A-mediated activity of p-methoxymethylcinnamate.
Methyl esters of hydroxycinnamic acids are photobiologically active. Cis(Z) and trans(E) p-methoxymethyl-cinnamate photosensitize Escherichia coli and Chinese hamster ovary cells. They also produce sister chromatid exchanges. Photosensitization is oxygen independent, and the cinnamates are not genetically active in the absence of light in the Ames Salmonella typhimurium test.
Ashwood-Smith
M
M
Biology Department, University of Victoria, B.C., Canada.
Stanley
C
C
Towers
G H
GH
Warrington
P J
PJ
D000818:Animals; D001711:Biotransformation; D016466:CHO Cells; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D002934:Cinnamates / Q000494:pharmacology* / Q000633:toxicity; D006224:Cricetinae; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D007536:Isomerism; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology* / Q000633:toxicity; D017319:Photosensitizing Agents / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000528:radiation effects; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014466:Ultraviolet Rays
D002934:Cinnamates; D009153:Mutagens; D017319:Photosensitizing Agents; C082164:4-methoxycinnamate methyl ester