[An evaluation of the radioprotective action of antioxidants on normal human cells and in genomic diseases by using different cytogenetic tests].
In studying the radioprotective action of natural and synthesised antioxydants a decreased yield of chromosome aberrations with respect to those in untreated cells was noted in normal cells irradiated in phase G1 whereas no radioprotective effect was found in cells irradiated in G0. The addition of antioxydants into the cell cultures from patients with Turner's syndrome did not change their radiosensitivity. No adaptive response was induced in lymphocytes from patients with Down's syndrome cultivated with vitamin E.
Zvereva
S V
SV
Mutovin
G R
GR
Khandogina
E K
EK
Marchenko
L F
LF
Neudakhin
E V
EV
Artamonov
R G
RG
Akif'ev
A P
AP
D000222:Adaptation, Physiological / Q000187:drug effects / Q000528:radiation effects; D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D004314:Down Syndrome / Q000235:genetics*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014424:Turner Syndrome / Q000235:genetics*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D011837:Radiation-Protective Agents; D014810:Vitamin E
Otsenka radiozashchitnogo deĭstviia antioksidantov na kletki cheloveka v norme i pri bolezniakh genoma s pomoshch'iu razlichnykh tsitogeneticheskikh testov.