[Molecular biology of endothelium-platelet interactions and thrombogenesis].
The net effect on vascular reactivity and thrombosis resulting from interactions of the endothelium with platelets is diverse. Platelet-endothelium interactions include platelet attachments to the vessels and the release of endothelium-derived platelet inhibitors. Identification of the platelet thrombin receptor revealed a unique proteolytic mechanism of receptor activation. The myriad of receptors, ligands, and the associated generation of intracellular messengers by heterotypic interactions offers numerous attractive targets for therapeutic intervention.
Shimada
K
K
Department of Cardiology, Jichi Medical School.
D000595:Amino Acid Sequence; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D013927:Thrombosis / Q000209:etiology*