Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids.
Lower pre-chemotherapy night time cortisol excretion predicted more severe cisplatin induced nausea and vomiting in 42 ovarian cancer patients receiving ondansetron as a single antiemetic agent. Dexamethasone administration added to the antiemetic effect of ondansetron principally in patients who had low excretion of cortisol.
Hursti
T J
TJ
Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden.
Fredrikson
M
M
Steineck
G
G
Börjeson
S
S
Fürst
C J
CJ
Peterson
C
C
D000328:Adult; D000368:Aged; D000932:Antiemetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology*; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D017294:Ondansetron / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy*
D000932:Antiemetics; D017294:Ondansetron; D003907:Dexamethasone; D004317:Doxorubicin; D002945:Cisplatin; D008558:Melphalan; D006854:Hydrocortisone