title: [Study on hydrolytic kinetics of metronidazole-phosphate in rabbit plasma by HPLC].
abstract: A HPLC method for the simultaneous determination of metronidazole and metronidazole-phosphate in rabbit plasma has been established. This method is simple, sensitive, reproducible and has a good linearity. It has been used to study the hydrolytic kinetics of metronidazole-phosphate in rabbit plasma. The results show that hydrolytic process of metronidazole-phosphate in vitro at 37 degrees C follows a first order kinetics with the rate constant 0.016 min-1 and half-life 43 min.
authors.forename: S
authors.initials: S
authors.lastname: Qu
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
authors.forename: X
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D007700:Kinetics; D008795:Metronidazole / Q000031:analogs & derivatives / Q000097:blood*; D011817:Rabbits; D012995:Solubility
chemical_list: D008795:Metronidazole