Ultrastructure of plasma cells in a patient with J chain disease.
Ultrastructural analysis of plasma cells was performed in a 74-year-old female patient with J chain disease. By electron microscopy, various characteristic findings were observed: lobulated nuclei, multinuclei, single sac loop-like structures, flocculent filament-like substances, nuclear inclusion bodies, cytoplasmic inclusion bodies, and multilamellar bodies. Our prior studies pointed out a poor prognosis in myeloma patients with these findings.
Sawamura
M
M
Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
Kurabayashi
H
H
Murakami
H
H
Sakura
T
T
Tamura
J
J
Kubota
K
K
Naruse
T
T
Tsuchiya
J
J
D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007072:Immunoglobulin D / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M / Q000097:blood; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D010950:Plasma Cells / Q000648:ultrastructure*; D011239:Prednisolone / Q000627:therapeutic use
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M; D003520:Cyclophosphamide; D011239:Prednisolone