title: The duration of leuprolide acetate administration prior to ovulation induction does not impact ovarian responsiveness to exogenous gonadotropins.
abstract: OBJECTIVE
  To evaluate the possible impact that the duration of GnRH agonist (GnRH-a) suppression has on subsequent ovarian responsiveness to exogenous gonadotropins.
  
  
  METHODS
  Prospective evaluation of the relationship between the duration of GnRH-a and multiple parameters of ovarian responsiveness.
  
  
  METHODS
  Assisted reproduction program in a large military tertiary care center.
  
  
  METHODS
  One hundred sixty-five women being pretreated with leuprolide acetate (LA) before ovulation induction with exogenous gonadotropins.
  
  
  METHODS
  Variable duration of LA administration before stimulation.
  
  
  METHODS
  Outcome measures include duration of stimulation, days until doubling of basal E2, number of ampules of exogenous gonadotropins, peak E2, number of mature follicles, and number of mature oocytes.
  
  
  RESULTS
  The duration of LA pretreatment had no effect on any of the parameters of ovarian responsiveness analyzed.
  
  
  CONCLUSIONS
  Once complete suppression of gonadal function is attained, the duration of GnRH-a suppression has no impact on subsequent ovarian responsiveness to exogenous gonadotropins.
authors.affiliation: Wilford Hall Medical Center, Lackland AFB, Texas 78236.
authors.forename: R T
authors.initials: RT
authors.lastname: Scott
authors.forename: G S
authors.initials: GS
authors.lastname: Neal
authors.forename: E H
authors.initials: EH
authors.lastname: Illions
authors.forename: C A
authors.initials: CA
authors.lastname: Hayslip
authors.forename: G E
authors.initials: GE
authors.lastname: Hofmann
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage* / Q000627:therapeutic use; D010053:Ovary / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D006062:Gonadotropins; D004958:Estradiol; D016729:Leuprolide