Gastrin and gastrin-related responses to infection with Ostertagia ostertagi in the calf.
The effects of a single challenge with 60,000 infective Ostertagia ostertagi larvae on blood and gastrointestinal mucosal gastrin concentrations, gastrin-producing G-cell numbers in the pyloric mucosa and growth of different parts of the gut were investigated in 16, two-and-a-half-month-old calves. Infected calves exhibited a rise in abomasal pH which was accompanied by a 145 per cent increase in wet weight of the fundic mucosa (P < 0.05) and a significant rise in blood total gastrin concentrations (P < 0.01). Circulating little gastrin (G-17) was unaffected. Pyloric mucosal total gastrin concentrations remained unaltered in the infected calves until day 28 when levels fell to 36.9 per cent of control group values (P < 0.01). Pyloric mucosal G-cell numbers declined during the experiment in the infected group. It is suggested that release of previously stored tissue gastrin and not a change in G-cell numbers contributes to the hypergastrinaemia associated with ostertagia infection in the calf.
Fox
M T
MT
Department of Veterinary Pathology, Royal Veterinary College, London.
Carroll
A P
AP
Hughes
S A
SA
Uche
U E
UE
Jacobs
D E
DE
Vaillant
C
C
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D005753:Gastric Mucosa / Q000473:pathology*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D010028:Ostertagia / Q000302:isolation & purification; D010029:Ostertagiasis / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D010270:Parasite Egg Count; D010435:Pepsinogens / Q000097:blood; D011863:Radioimmunoassay; D012016:Reference Values
D005755:Gastrins; D010435:Pepsinogens