Increased respiratory drive as an inhibitor of oral feeding of preterm infants.
This study was designed to determine whether increased respiratory drive induced by inhalation of carbon dioxide would alter the reflex and voluntary components of feeding. For 10 preterm infants (mean +/- SD: postconceptional age at study, 34 +/- 2 weeks; weight, 2.1 +/- 0.2 kg), four trials of nutritive feeding were offered: two while the infants were inhaling a gas mixture containing 40% oxygen and two while the infants were breathing 40% oxygen and 7% carbon dioxide. Nasal airflow was monitored with a pneumotachygraph. Pressure-sensitive catheters in the esophagus and in the feeding nipple were used to detect swallowing and sucking. Sucking frequency and pattern, rate of swallowing, end-tidal carbon dioxide, and minute ventilation were recorded for 30-second epochs during feeding. When the inhaled gas mixture was switched from 40% oxygen to 40% oxygen and 7% carbon dioxide, sucking frequency decreased from 53 +/- 10 to 48 +/- 12 and from 54 +/- 12 to 40 +/- 19 sucks/min, respectively (p < 0.005). Frequency of swallowing also fell during the two feeding epochs on 7% carbon dioxide, from 45 +/- 15 to 40 +/- 15 and from 43 +/- 14 to 31 +/- 16 swallows/min (p < 0.003). Thus acute hypercapnea was accompanied by a decrease in rate of both sucking and swallowing during nutritive feeding. Increased ventilatory drive may directly inhibit nutritive feeding behavior in premature infants.
Timms
B J
BJ
Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
DiFiore
J M
JM
Martin
R J
RJ
Miller
M J
MJ
D001903:Bottle Feeding; D002245:Carbon Dioxide / Q000008:administration & dosage; D003679:Deglutition / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D010100:Oxygen / Q000008:administration & dosage; D012129:Respiratory Function Tests / Q000379:methods / Q000706:statistics & numerical data; D015656:Respiratory Mechanics / Q000187:drug effects; D013391:Sucking Behavior / Q000187:drug effects
D002245:Carbon Dioxide; D010100:Oxygen