title: The effect of intracranial hypotension on cerebral blood flow in a feline model.
abstract: Intracranial hypotension is a known clinical entity but its pathophysiology has been meagerly studied. Any setting with cerebrospinal fluid leakage or drainage can cause intracranial hypotension. A feline model of kaolin induced chronic hydrocephalus with controlled cerebrospinal fluid drainage from a lateral ventricle yields reproducible intracranial hypotension of up to -15 torr for several hours to -80 torr of about 10 minutes. The magnitude of this hypotension is significantly greater than can be attained by cisterna magna drainage. This new model allows multiple cerebral parameters to be studied during intracranial hypotension. In 11 cats with stable blood pressure and intracranial hypotension of at least -15 torr, regional blood flow utilizing the hydrogen clearance method in the cerebral cortex and subcortical nuclei was unchanged relative to the baseline. These results imply that: 1) cerebral vascular autoregulation is maintained during significantly increased perfusion pressure due to negative intracranial pressure, 2) the symptomatology of clinical intracranial hypotension is not due to decreased cerebral perfusion.
authors.affiliation: Neurosurgery Department, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Pomeranz
authors.forename: L
authors.initials: L
authors.lastname: Beni
authors.forename: M N
authors.initials: MN
authors.lastname: Shalit
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D002415:Cats; D002552:Cerebral Ventricles / Q000098:blood supply; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D007427:Intracranial Pressure / Q000502:physiology*; D008959:Models, Neurological; D012039:Regional Blood Flow / Q000502:physiology