title: Enhancing mediastinal mass at MR: Castleman disease.
abstract: We report a case of an enhancing middle mediastinal mass imaged by MR and CT. Repeated nondiagnostic biopsies in this 25-yr-old male patient had resulted in profuse hemorrhage. Final pathological diagnosis after thoracotomy and debulking was Castleman disease. This is a rare, benign lymphoproliferative disorder of uncertain etiology. Histological varieties include the hyaline vascular type (80-90%) and the plasma cell type (10-20%). Cure is generally accomplished via surgical excision. This entity should be included in the differential diagnosis of enhancing mediastinal lesions, prompting awareness of the potential for bleeding complications following biopsy.
authors.affiliation: Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109.
authors.forename: M L
authors.initials: ML
authors.lastname: Hsieh
authors.forename: L E
authors.initials: LE
authors.lastname: Quint
authors.forename: J M
authors.initials: JM
authors.lastname: Faust
authors.forename: J E
authors.initials: JE
authors.lastname: Turner
mesh_terms: D000328:Adult; D001706:Biopsy / Q000009:adverse effects; D005871:Castleman Disease / Q000175:diagnosis*; D003287:Contrast Media; D003937:Diagnosis, Differential; D004338:Drug Combinations; D019786:Gadolinium DTPA; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis*; D008536:Meglumine; D009942:Organometallic Compounds; D004369:Pentetic Acid; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA