title: Changing trends in the treatment of asthma in a tertiary Canadian pediatric hospital.
abstract: During the last few years there has been a major change in the perception of childhood asthma management, with more focus on the anti-inflammatory aspects of therapy, the use of inhaled ipratroprium bromide, and decreased home usage of theophylline. Our clinical impression that the management of asthma at our institution has altered in response to these trends prompted us to review our experience with childhood asthma. A random sample of approximately 70 cases was reviewed from admissions to The Hospital for Sick Children during the first 6 months of 1987 and 1990. There was a major reduction in theophylline usage in 1990 accompanied by increased use of ipratroprium and oral corticosteroids. Significantly fewer cases of potentially toxic theophylline serum levels were observed in 1990, suggesting increased awareness of the this drug's narrow therapeutic margin of safety. In 1990, patients tended to be pyrexial and were treated with antibiotics more often. They were also younger, which may explain the higher pulse and respiratory rates observed. Despite these trends toward younger, sicker patients being admitted to the hospital, the length of stay did not increase, and similar numbers needed intensive care. This suggests that the shift in therapeutic modality did not affect hospitalized asthmatic children adversely.
authors.affiliation: Department of Pediatrics and Research Institute, Hospital for Sick Children Toronto, Ontario, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Scolnik
authors.forename: S
authors.initials: S
authors.lastname: Graf
authors.forename: G
authors.initials: G
authors.lastname: Koren
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D002170:Canada; D002648:Child; D002675:Child, Preschool; D004358:Drug Therapy / Q000639:trends; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D012189:Retrospective Studies