Histocompatibility antigens and La Crosse encephalitis.
Major histocompatibility complex antigens (HLA-ABC and -DR loci) on lymphocytes from 79 patients with La Crosse encephalitis were compared with those of 69 control subjects. Nine patients (11%) and none of the control population had HLA-B49 (P < .01, uncorrected for multiple comparisons). Of La Crosse encephalitis patients with acute-phase seizures, only 2 (7%) were positive for HLA-DR5, whereas 16 (37%) of nonseizure patients were positive for that antigen (P < .025). These findings suggest that susceptibility and complications associated with this disease may have an immunogenetic component.
Case
K L
KL
Department of Laboratory Medicine, Lutheran Hospital-La Crosse, Wisconsin.
West
R M
RM
Smith
M J
MJ
D002141:Encephalitis Virus, California; D004670:Encephalitis, California / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans
D006680:HLA Antigens; D006684:HLA-DR Antigens