Effect on cardiac contractile force from addition of cations and oxygen to iohexol. Comparison with other low-osmotic contrast media in the isolated rabbit heart during normal and reduced perfusion pressure.
The coronary arteries of the isolated rabbit heart were perfused with different contrast media (CM). The effects on cardiac contractile force (CF) from enriching iohexol solutions with sodium, calcium, potassium, magnesium and oxygen were investigated. The effects were studied during normal and reduced perfusion pressure; the latter was intended to simulate flow conditions distal to proximal stenotic processes of the coronary arteries. By adding the above mentioned cations to iohexol (175 mg I/ml) the smallest influence on CF was found when the CM contained 30 mM NaCl, 0.3 mM CaCl2, 0.9 mM KCl and 0.3 mM MgCl2 and this influence on CF was significantly less than caused by iohexol with 30 mM NaCl (p < or = 0.01). The influence on CF was further reduced when this iohexol solution was oxygenated with 100% oxygen (p < or = 0.001). This modified iohexol solution caused a significantly smaller influence on CF than the low-osmotic media iohexol, iopamiro, ioversol and ioxaglate (p < or = 0.001). Ioxaglate caused the greatest decrease in CF of all the CM (p < or = 0.001) and to a greater extent during reduced flow than during normal flow (p < or = 0.01). In conclusion, iohexol enriched with a balanced electrolyte solution and saturated with oxygen had a smaller adverse effect on contractility than iohexol, iopamidol, ioversol and ioxaglate.
Besjakov
J
J
Department of Experimental Research, Malmö General Hospital, University of Lund, Sweden.
Bååth
L
L
Almén
T
T
Oksendal
A N
AN
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002412:Cations / Q000494:pharmacology*; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007472:Iohexol / Q000008:administration & dosage / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009994:Osmolar Concentration; D010100:Oxygen / Q000494:pharmacology; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology
D002412:Cations; D003287:Contrast Media; D007472:Iohexol; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D010100:Oxygen; D002118:Calcium