[Flare-up study and gonadotropin extinction curve in patients treated with long-acting triptorelin, 3.75 mg im].
Flare-Up study and gonadotropin-oestradiol extinction pattern were examined in two groups of 11 and 10 patients during treatment with Triptorelin LA. Plasmatic gonadotropin and oestradiol levels were evaluated by LIA and RIA respectively. The resulting data confirm that LH levels show an increase sixfold than basic values (Flare-Up effect), while FSH levels increase twice after two days of treatment. This effect was exhausted in five days. Gonadotropin-oestradiol extinction pattern demonstrates a condition of hypogonadotropic hypogonadism after two weeks of treatment with LHRHa. This study could explain some aspects of a LHRH-a action, namely for their clinical use in ovulation induction protocols.
Vizziello
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Istituto di Ricovero e Cura a Carattere Scientifico, S. De Bellis, Castellana Grotte BA.
D'Amato
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Trentadue
R
R
Fanizza
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G
D000328:Adult; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000097:blood* / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D010062:Ovulation Induction; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D017329:Triptorelin Pamoate / Q000494:pharmacology* / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D017329:Triptorelin Pamoate; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Studio del Flare-Up e delle curve di estinzione delle gonadotropine in pazienti trattate con Triptorelina Long Acting 3,75 mg I.M.