The integrin VLA-4 mediates leukocyte recruitment to skin inflammatory sites in vivo.
We have developed a murine model of delayed type hypersensitivity (DTH) to the chemical oxazalone. Purification of T lymphocytes from immunized animals allows adoptive transfer of the specific DTH response into naive recipients injected intravenously with primed T cells. Transfer of DTH elicited by injection with immune T cells can be specifically inhibited by antibodies to the VLA-4 integrin receptor. These results suggest a major role for VLA-4 in skin inflammatory reactions in vivo.
Elices
M J
MJ
CYTEL Corporation, San Diego, CA 92121.
Tamraz
S
S
Tollefson
V
V
Vollger
L W
LW
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D003872:Dermatitis / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D016219:Immunotherapy, Adoptive; D007962:Leukocytes / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000276:immunology; D016029:Receptors, Very Late Antigen / Q000502:physiology*
D016029:Receptors, Very Late Antigen; D010081:Oxazolone