[Soluble interleukin 2 receptor (sIL-2R) in patients with esophageal carcinoma].
The serum levels of soluble IL-2 receptor (sIL-2R) were determined in 30 patients with esophageal carcinoma and in 32 normal subjects. In addition, the ability of PBMC to express IL-2 receptor (IL-2R) and release sIL-2R following PHA stimulation were studied in vitro. sIL-2R concentrations in sera derived from patients were significantly higher than in sera derived from healthy controls (P < 0.001). The expression of IL-2R by PBMC were decreased in patients, but no difference was demonstrated between the patients and healthy controls in the sIL-2R release. The increased levels of sIL-2R and decreased IL-2R expression by PBMC in patients might reflect the immunologic abnormalities in patients with esophageal carcinoma.
Duan
Z F
ZF
Department of Immunology & Microbiology, Henan Medical University, Zhengzhou.
D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
D015375:Receptors, Interleukin-2