The prolongation of drug action in the treatment of diseases of the nose and paranasal sinuses.
In order to prolong drug contact with the mucous membrane, and thus therapeutic action, cellulose polymers have been used. These polymers exert no toxic action on liver function. The release of the drug from the polymer depends on the degree of polymer viscosity. The use of drug-containing polymers in the treatment of nasal diseases and paranasal sinusitis is highly effective.
Piskunov
S
S
Medical Institute, Kursk, GOS, Moscow, Russia.
Piskunov
G
G
Razinkov
S
S
Lazarev
A
A
Erofeeva
L
L
D000818:Animals; D001682:Biological Availability; D002266:Carboxymethylcellulose Sodium; D004155:Diphenhydramine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004304:Dosage Forms; D007322:Instillation, Drug; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D009668:Nose Diseases / Q000188:drug therapy*; D010254:Paranasal Sinus Diseases / Q000188:drug therapy*; D011817:Rabbits; D011898:Ranidae; D051381:Rats; D012996:Solutions; D013997:Time Factors
D004304:Dosage Forms; D012996:Solutions; D004155:Diphenhydramine; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium