The duration of leuprolide acetate administration prior to ovulation induction does not impact ovarian responsiveness to exogenous gonadotropins.
OBJECTIVE
To evaluate the possible impact that the duration of GnRH agonist (GnRH-a) suppression has on subsequent ovarian responsiveness to exogenous gonadotropins.


METHODS
Prospective evaluation of the relationship between the duration of GnRH-a and multiple parameters of ovarian responsiveness.


METHODS
Assisted reproduction program in a large military tertiary care center.


METHODS
One hundred sixty-five women being pretreated with leuprolide acetate (LA) before ovulation induction with exogenous gonadotropins.


METHODS
Variable duration of LA administration before stimulation.


METHODS
Outcome measures include duration of stimulation, days until doubling of basal E2, number of ampules of exogenous gonadotropins, peak E2, number of mature follicles, and number of mature oocytes.


RESULTS
The duration of LA pretreatment had no effect on any of the parameters of ovarian responsiveness analyzed.


CONCLUSIONS
Once complete suppression of gonadal function is attained, the duration of GnRH-a suppression has no impact on subsequent ovarian responsiveness to exogenous gonadotropins.
Scott
R T
RT
Wilford Hall Medical Center, Lackland AFB, Texas 78236.
Neal
G S
GS
Illions
E H
EH
Hayslip
C A
CA
Hofmann
G E
GE
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage* / Q000627:therapeutic use; D010053:Ovary / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D012044:Regression Analysis; D013997:Time Factors
D006062:Gonadotropins; D004958:Estradiol; D016729:Leuprolide