title: Extensive osteolysis around an aseptic, stable, uncemented total knee replacement.
abstract: Extensive osteolysis occurred around an aseptic, well-fixed, stable, uncemented total knee prosthesis. At the time of revision, tibial polyethylene wear and minimal metal-on-metal contact were present. A hypertrophic synovium-like membrane abutted bone in regions of osteolysis. Examination of this membrane revealed polyethylene-wear debris and significant levels of chromium, cobalt, and titanium. Wear debris--polyethylene, metal, or a combination of both--may be responsible for the osteolytic process in this case.
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: D J
authors.initials: DJ
authors.lastname: Berry
authors.forename: L E
authors.initials: LE
authors.lastname: Wold
authors.forename: J A
authors.initials: JA
authors.lastname: Rand
mesh_terms: D001843:Bone Cements; D002857:Chromium / Q000032:analysis; D003035:Cobalt / Q000032:analysis; D005269:Femur / Q000473:pathology*; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology* / Q000473:pathology; D011095:Polyethylenes / Q000032:analysis; D011475:Prosthesis Failure; D013583:Synovial Membrane / Q000737:chemistry; D014025:Titanium / Q000032:analysis
chemical_list: D001843:Bone Cements; D011095:Polyethylenes; D002857:Chromium; D003035:Cobalt; D014025:Titanium