[Modeling of the bactericidal effect of spiramycin. Choice of a pharmacodynamic model].
The modelling of in vitro growth curves of Staphylococcus aureus ATCC 6538P at different pHs, of spiramycin killing curves and of the dose-effect relationship was performed. The growth curve was characterised by a Volterra-Kostitzin differential model, the main parameters of which were the bacterial growth rate constant of 0.95 +/- 0.13 h-1 and a lag-time of 0.74 +/- 0.36 h. The Zhi model used for bactericidal kinetics showed the same bacterial killing rate constant from a minimum concentration characteristic of "time-dependent" antibiotics. This differential model incorporated with pharmacokinetic models could lead to a rationale for proper dosage regimens.
Renard
L
L
Centre national d'études vétérinaires et alimentaires, laboratoire des médicaments vétérinaires, Fougères, France.
Sanders
P
P
Laurentie
M
M
D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D015572:Spiramycin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
D003470:Culture Media; D015572:Spiramycin
Modélisation de l'effet bactéricide de la spiramycine. Choix d'un modèle pharmacodynamique.