Immunodeficiency with increased immunoglobulin M associated with growth hormone insufficiency.
Growth hormone deficiency associated with hypogammaglobulinemia has been reported only in a few publications. Our patient was a male with recurrent episodes of infections. Serum immunoglobulin (Ig) G was extremely low although IgM concentration was much greater than the normal limit. Growth hormone responses to insulin, 1-Dopa and growth hormone-releasing hormone were low. The mean growth hormone concentration during sleep was less than the normal limit. These results are consistent with hyper-IgM immunodeficiency associated with growth hormone deficiency. The mode of transmission appears to be autosomal dominant. This combination has not been reported previously.
Ohzeki
T
T
Department of Pediatrics, Faculty of Medicine, Tottori University, Yonaga, Japan.
Hanaki
K
K
Motozumi
H
H
Ohtahara
H
H
Hayashibara
H
H
Harada
Y
Y
Okamoto
M
M
Shiraki
K
K
Tsuji
Y
Y
Emura
H
H
D000293:Adolescent; D006130:Growth Disorders / Q000150:complications / Q000235:genetics / Q000276:immunology*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D010375:Pedigree
D007075:Immunoglobulin M; D013006:Growth Hormone