Tumor lysis syndrome complicating treatment of widespread metastatic abdominal rhabdomyosarcoma.
In this paper we describe a 9-year-old girl with abdominal embryonal rhabdomyosarcoma. She had ascites and widespread metastatic disease at presentation and was oliguric but had a normal creatinine. Following the start of chemotherapy she developed acute renal failure secondary to the tumor lysis syndrome, requiring hemodialysis, and had considerable myelotoxicity.
Khan
J
J
Department of Paediatric Oncology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Broadbent
V A
VA
D000008:Abdominal Neoplasms / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D012208:Rhabdomyosarcoma / Q000188:drug therapy* / Q000556:secondary*; D015275:Tumor Lysis Syndrome / Q000209:etiology*