[The effect of quercetin on the metabolic processes in combined body exposure to hypoxia and hyperthermia].
Quercetin given in a dose of 100 mg/kg 3 hours before acute systemic hypoxia (10 ob%) combined with hyperthermia (43 degrees C) has been demonstrated to prevent a drastic activation of lipid peroxidation and arachidonic acid metabolism parallel to a marked decrease the activity of the body's antioxidative and detoxifying systems under the conditions studied. The pronounced pharmacotherapeutical effects was due to its antioxidative and antilipooxygenase activities and its ability to induce the hepatic monooxygenase system.
Luk'ianchuk
V D
VD
Savchenkova
L V
LV
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005334:Fever / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D011794:Quercetin / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D011794:Quercetin
Vliianie kvertsetina na metabolicheskie protsessy pri sochetannom vozdeĭstvii na organizm gipoksii i gipertermii.