title: Kinetics of expulsion of Haemonchus contortus from sheep and jirds after treatment with closantel.
abstract: Experiments were conducted in sheep after intramuscular treatment with closantel and in jirds after oral treatment with closantel to determine when expulsion of established H. contortus commences. Expulsion starts at about 8 h in sheep and coincides with the onset of reduced motility in worms recovered from the abomasum. In jirds, expulsion starts by 2 h after treatment. Experiments also conducted in jirds showed that infective larvae are first killed by circulating closantel 3 days after infection, when blood feeding starts, and that by 8 days 80% of larvae are lost.
authors.affiliation: Department of Veterinary Pathology, University of Sydney, Australia.
authors.forename: J T
authors.initials: JT
authors.lastname: Rothwell
authors.forename: N C
authors.initials: NC
authors.lastname: Sangster
authors.forename: G A
authors.initials: GA
authors.lastname: Conder
authors.forename: R J
authors.initials: RJ
authors.lastname: Dobson
authors.forename: S S
authors.initials: SS
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D004064:Digestive System / Q000469:parasitology; D005260:Female; D005849:Gerbillinae; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects; D008297:Male; D012458:Salicylanilides / Q000494:pharmacology / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
chemical_list: D000871:Anthelmintics; D012458:Salicylanilides; C023342:closantel