title: Treatment of chronic hepatitis C with recombinant interferon alfa-2b.
abstract: In a study of 87 patients with chronic hepatitis C, 12 months' treatment with interferon alfa-2b at a dose of 6 million units (MU) three times per week seemed to be more effective than treatment with 3 MU three times a week for two months plus 1.5 MU three times a week for 10 months in increasing the percentage of long term responders. The percentage of patients in whom alanine amino-transferase activities returned to normal was highest in the 6 MU group, as was the percentage of responders who sustained this normal activity after treatment. Side effects were moderate and self-limited in most patients.
authors.affiliation: Department of Infectious Diseases, II Medical School, University of Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Piazza
authors.forename: R
authors.initials: R
authors.lastname: Orlando
authors.forename: G
authors.initials: G
authors.lastname: Tosone
authors.forename: D
authors.initials: D
authors.lastname: Tiseo
authors.forename: M C
authors.initials: MC
authors.lastname: Conte
authors.forename: F
authors.initials: F
authors.lastname: Minervini
authors.forename: G
authors.initials: G
authors.lastname: Santoro
authors.forename: F
authors.initials: F
authors.lastname: Scordino
authors.forename: D
authors.initials: D
authors.lastname: Vitale
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006526:Hepatitis C / Q000201:enzymology / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D000410:Alanine Transaminase