Cor pulmonale and silicosis: a necropsy based case-control study.
The presence of cor pulmonale at death in relation to other factors such as emphysema, silicosis, and thromboembolism was analysed in a case-control study of 732 South African gold miners. Marked emphysema was the highest risk factor with an odds ratio of 21.32 (95% confidence interval (95% CI) 5.02-90.7), then extensive silicosis (OR 4.95, 95% CI 2.92-8.38) and thromboembolic disease (OR 1.92, 95% CI 1.37-2.69). Age and smoking were not significant predictors of cor pulmonale.
Murray
J
J
National Centre for Occupational Health, Johannesburg, South Africa.
Reid
G
G
Kielkowski
D
D
de Beer
M
M
D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D016022:Case-Control Studies; D006046:Gold; D006801:Humans; D008875:Middle Aged; D008906:Mining; D011656:Pulmonary Emphysema / Q000150:complications* / Q000473:pathology; D011660:Pulmonary Heart Disease / Q000209:etiology* / Q000473:pathology; D012829:Silicosis / Q000150:complications* / Q000473:pathology
D006046:Gold