title: Reduced gastric mucosal blood flow in patients with portal-hypertensive gastropathy.
abstract: Although congestive gastric mucosal circulation has been suggested in patients with portal-hypertensive gastropathy, whether it is due to "active" (overflow) or "passive" (stasis) congestion is not known. To answer this question, we assessed regional gastric mucosal blood flow with laser Doppler flowmetry in 57 patients with portal hypertension and 30 controls. Twelve patients had portal-hypertensive gastropathy of the antrum: in eight it was mild and in four it was severe. Portal-hypertensive gastropathy of the corpus was seen in 32 patients: it was mild in 24 and severe in 8. Thus prevalence of portal-hypertensive gastropathy was higher in the corpus than in the antrum (p < 0.01). In the antrum, gastric mucosal blood flow was significantly lower (p < 0.05) in patients with severe portal-hypertensive gastropathy (0.54 +/- 0.27 V) than in controls (1.12 +/- 0.44 V), whereas the values in patients without portal-hypertensive gastropathy (0.90 +/- 0.35 V) and with mild portal-hypertensive gastropathy (0.91 +/- 0.31 V) were not significantly different from the values in controls (p < 0.05 on one-way analysis of variance). In the corpus, gastric mucosal blood flow was significantly lower in patients with mild (0.75 +/- 0.25 V) or severe portal-hypertensive gastropathy (0.42 +/- 0.22 V) than in controls (1.16 +/- 0.37 V) (p < 0.01 and p < 0.01, respectively) whereas the value in patients without portal-hypertensive gastropathy (0.99 +/- 0.37 V) was not significantly different from values in controls (p < 0.01 on one-way analysis of variance).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Second Department of Medicine, Kurume University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwao
authors.forename: A
authors.initials: A
authors.lastname: Toyonaga
authors.forename: M
authors.initials: M
authors.lastname: Ikegami
authors.forename: K
authors.initials: K
authors.lastname: Oho
authors.forename: M
authors.initials: M
authors.lastname: Sumino
authors.forename: H
authors.initials: H
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Sakaki
authors.forename: H
authors.initials: H
authors.lastname: Shigemori
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: K
authors.initials: K
authors.lastname: Tanikawa
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum; D013272:Stomach Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology