The impact of some parameters on linkage analysis of Alzheimer's disease.
The two-point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age-dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage. However, it is clear that, in some cases, it may lead to false positive evidence of linkage.
Xu
J F
JF
School of Hygiene, Johns Hopkins University, Baltimore, Maryland.
Taylor
E W
EW
Lung
F W
FW
Chung
A S
AS
Chase
G A
GA
Maestri
N E
NE
Meyers
D A
DA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001900:Boston / Q000453:epidemiology; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008875:Middle Aged
D005819:Genetic Markers