title: A review of 28 years of treating advanced ovarian cancer.
abstract: The treatment of advanced ovarian cancer at the Women's Clinic of the University of Pécs, Hungary, during 1962-1989 is described in a historical review. The results of 82 patients treated with cyclophosphamide (C), 83 patients treated with non-cisplatin (CMV or CAV) and 41 patients treated with a cisplatin (CAP) combinations were compared. Progression-free survival was better with the CMV or CAV than with C. CAP was associated with significantly better remission rates, survival and progression-free survival than the other treatments. Analysis supports the prognostic importance of post-surgical residual tumour size. Consolidation radiotherapy and maintenance or second line chemotherapy are recommended.
authors.affiliation: Department of Obstetrics and Gynecology, University of Pécs, Hungary.
authors.forename: C F
authors.initials: CF
authors.lastname: Krommer
authors.forename: J P
authors.initials: JP
authors.lastname: Szalai
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011446:Prospective Studies; D012074:Remission Induction; D012086:Reoperation; D012189:Retrospective Studies; D016879:Salvage Therapy; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014750:Vincristine; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D008727:Methotrexate