Astins A and B, antitumor cyclic pentapeptides from Aster tataricus.
Two novel antitumor chlorine- and alloThr-containing cyclic pentapeptides, named astins A and B, both of which were isomers and took a cis configuration in one of the amide bonds, were isolated from Aster tataricus together with astin C. Their structures were solved by spectroscopic analysis and chemical degradation.
Morita
H
H
Tokyo College of Pharmacy, Japan.
Nagashima
S
S
Takeya
K
K
Itokawa
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000188:drug therapy
D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; C082413:astin A; C082414:astin B