title: A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.
abstract: The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.
authors.affiliation: Department of Medical Genetics, University of Groningen, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Kok
authors.forename: R
authors.initials: R
authors.lastname: Hofstra
authors.forename: A
authors.initials: A
authors.lastname: Pilz
authors.forename: A
authors.initials: A
authors.lastname: van den Berg
authors.forename: P
authors.initials: P
authors.lastname: Terpstra
authors.forename: C H
authors.initials: CH
authors.lastname: Buys
authors.forename: B
authors.initials: B
authors.lastname: Carritt
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002893:Chromosomes, Human, Pair 3; D004247:DNA / Q000737:chemistry; D016147:Genes, Tumor Suppressor; D006801:Humans; D008025:Ligases / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D044764:Ubiquitin-Activating Enzymes; D044767:Ubiquitin-Protein Ligases
chemical_list: D004247:DNA; D044767:Ubiquitin-Protein Ligases; D008025:Ligases; D044764:Ubiquitin-Activating Enzymes