title: [The influence of the new phosphodiesterase inhibitor enoximone in patients with an acute catecholamine-refractory heart insufficiency during open-heart surgery].
abstract: 19 patients in whom cardiopulmonary bypass (cpb) was performed during different types of cardiac operations, developed myocardial failure which remained refractory to inotropic support with increasing doses of adrenaline, dopamine and dobutamine, so that it was impossible to discontinue cpb. After changing the therapeutic approach to a new regime consisting of adrenaline, dopamine and enoximone, low-output syndrome (LCOS) could be successfully reversed in 12 of the 19 patients. In the 7 remaining patients blood pressure dropped in a clinically relevant way under treatment with enoximone. 5 of these patients needed intraaortic balloon pumping (IABP) inspite of the application of enoximone, before cpb could be successfully discontinued. In three patients receiving enoximone, persisting ventricular tachyarrhythmia appeared under treatment, and disappeared after discontinuation of the drug. One patient needed IABP and left heart bypass by means of the centrifugal pump before cpb could be duly discontinued. One patient died intraoperatively due to untreatable right ventricular failure and inability to discontinue cpb. It is concluded that enoximone represents a useful drug in a significant number of patients developing heart failure refractory to inotropic support, on emerging from cpb during cardiac surgery.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und spezielle Intensivmedizin, Universität Bonn.
authors.forename: H K
authors.initials: HK
authors.lastname: Murday
authors.forename: M
authors.initials: M
authors.lastname: Jungblut
authors.forename: N J
authors.initials: NJ
authors.lastname: Limberg
authors.forename: M
authors.initials: M
authors.lastname: Fischer
authors.forename: J
authors.initials: J
authors.lastname: Likungu
authors.forename: P G
authors.initials: PG
authors.lastname: Kirchhoff
mesh_terms: D000328:Adult; D000368:Aged; D002303:Cardiac Output, Low / Q000188:drug therapy / Q000209:etiology*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004280:Dobutamine / Q000627:therapeutic use*; D004298:Dopamine / Q000627:therapeutic use*; D017335:Enoximone / Q000627:therapeutic use*; D004837:Epinephrine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine; D017335:Enoximone; D004298:Dopamine; D004837:Epinephrine
vernacular_title: Der Einfluss des neueren Phosphodiesterase-Inhibitors Enoximon bei Patienten mit einer akuten katecholamin-refraktären Herzinsuffizienz während Operationen am offenen Herzen.