Chromosomal findings in cultured melanocytes from a giant congenital nevus.
A giant congenital pigmented nevus was observed in a newborn male. A melanocyte culture was established from nevus fragments removed at age 6 days. Analysis of 136 metaphases harvested from the primary culture showed 74% normal mitoses, 22% polyploids, and 4% mitoses with chromosome rearrangements involving in particular 1p, 12q, and 19p. In addition, the culture showed a high level of HLA-DR expression. Although histology showed no sign of malignancy, these findings may illustrate one of the first events which might eventually progress toward malignancy.
Heimann
P
P
Laboratory of Cytogenetics, University Hospital Brugmann, Brussels, Belgium.
Ogur
G
G
De Busscher
C
C
Morandini
R
R
Libert
A
A
Vamos
E
E
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D008544:Melanocytes / Q000648:ultrastructure; D009508:Nevus, Pigmented / Q000151:congenital / Q000235:genetics*