Pharmacokinetics of 14C-N-N'-dicyclopropyl-methyl-piperazine-dichlorhydrate. 3rd communication: whole-body autoradiographic study in Cynomolgus monkeys after oral administration.
A distribution study was carried out on Cynomolgus monkeys (Macaca fascicularis) dosed orally with 14C-labelled N-N'-dicyclopropyl-methyl-piperazine-dichlor-hydrate 14C-Ino 2628-CZ and sacrificed 2, 8 and 24 h after dosage, using whole-body autoradiography. It is demonstrated that radioactivity is found in all the body; high intakes occur in melanin containing tissues, in blood-forming organs, and in accessory genital glands. Moreover, radioactivity crosses the blood-brain barrier and is mainly localized in hippocampus, caudate, putamen and frontal cortex.
Benard
P
P
Laboratoire de Radioéléments et Etudes Métaboliques, I.N.R.A. E.N.V.T., Toulouse, France.
Dormard
Y
Y
Houin
G
G
Declume
C
C
Malbosc
R
R
Tufenkji
A E
AE
Galtier
P
P
Alvinerie
M
M
D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008252:Macaca fascicularis; D010879:Piperazines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D002316:Cardiotonic Agents; D010879:Piperazines; C059182:N,N'-dicyclopropylmethylpiperazine