Energy metabolism in muscle paresis and recovery studied by 31P-MR spectroscopy: a case report.
We report a 31P Magnetic Resonance Spectroscopy (31P-MRS) study on the changes of energy metabolism in human leg anterior and lateral compartment muscles with paresis due to compression from a herniated lumbar disc at the L4-L5 level and recovery to normality. A low phosphocreatine to inorganic phosphate ratio due to both decreased phosphocreatine and increased inorganic phosphate contents and a normal intracellular pH were the features of muscles with paresis. Changes of 31P-MRS parameters were followed during 18 weeks of treatment with physical therapy until complete recovery. Results show that 31P-MRS is a useful clinical tool for detecting even small biochemical changes that may occur in muscles and for checking the effects of therapy.
Funicello
R
R
Cattedra di Biochimica Clinica, Università di Bologna.
Barbiroli
B
B
Zaniol
P
P
Martinelli
P
P
D004734:Energy Metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000378:metabolism; D007866:Leg; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D010243:Paralysis / Q000175:diagnosis* / Q000378:metabolism* / Q000503:physiopathology; D010758:Phosphorus
D010758:Phosphorus