[An evaluation of the protection by mono-oxygenase enzyme-inducing pharmacological agents against pesticides by the lethality indices].
Experiments with non-inbred mice established that there was a direct correlation between the defence index (DI) of monooxygenase enzyme (ME) inductors and the coefficient of variation of LD50 which were used to determine the DI of toxicants, which reflected the LD16-LD84 interval. This interval should be borne in mind while evaluating the effect of pharmacological agents exerting an inducing action of P-450-dependent hepatic monooxygenases, which allows the formula to be constructed.
Zabrodskiĭ
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Liniuchev
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D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D010105:Oxygenases / Q000096:biosynthesis / Q000187:drug effects*; D010575:Pesticides / Q000506:poisoning*; D010634:Phenobarbital / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000401:mortality
D010575:Pesticides; D010105:Oxygenases; D010634:Phenobarbital
Otsenka zashchity farmakologicheskimi sredstvami, indutsiruiushchimi monooksigenaznye fermenty, ot pestitsidov po pokazateliam letal'nosti.