[Positron-emission tomographic study of the dopaminergic system in a case of secondary unilateral tremor after mesencephalic hematoma].
A 30 year-old woman developed a postural and rest tremor of the left hand following a right peduncular post-traumatic hematoma. Two years later, positron emission tomography showed a marked decrease in [18F] fluorodopa uptake contrasting with a normal [76Br] bromolisuride uptake in the right striatum. This suggests that: 1) chronic unilateral dopaminergic striatal denervation may occur without persistent D2 dopaminergic receptor upregulation in humans; and 2) symptomatic mesencephalic tremor may be, at least in part, related to dopaminergic striatal denervation.
De Recondo
A
A
Service Hospitalier Frédéric Joliot, DRIPP, CEA, Orsay.
Rondot
P
P
Loc'h
C
C
Crouzel
C
C
Dao-Castellana
M H
MH
Bathien
N G
NG
Rascol
O
O
Clanet
M
M
De Recondo
J
J
Samson
Y
Y
D000328:Adult; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000175:diagnosis; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008636:Mesencephalon; D014055:Tomography, Emission-Computed; D014202:Tremor / Q000000981:diagnostic imaging / Q000209:etiology*
D004298:Dopamine
Etude du système dopaminergique en tomographie par émission de positons dans un cas de tremblement unilatéral secondaire à un hématome mésencéphalique.