[Studies on the bioavailability and pharmacokinetics of nimodipine tablet in human body].
The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method. The commercially available conventional tablet A and the tablet formulation B were compared with the reference solution C in vivo. The pharmacokinetic parameters of nimodipine in vivo were estimated by using PKBP--N1 program on the basis of one compartment open model. After administration of 120 mg dose of B, the pharmacokinetic parameters were as follows: Tp = 0.977 h, Cmax = 44.28 ng/ml, ka = 2.02 h-1, t1/2 = 1.63 h, Vd = 26.25 L/kg, AUC = 136.56 ng.h-1.ml-1. The result imply that nimodipine is absorbed rapidly, distributed widely in the body, and also eliminated at a fairly rapid rate. The bioavailability of A and B relative to C was 16.01% and 82.39% respectively. The new tablet formulation B is superior to tablet A.
Yan
X F
XF
Institute of Clinical Pharmacology, Zhejiang Medical University, Hangzhou.
Ding
D Y
DY
Liu
R J
RJ
D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009553:Nimodipine / Q000493:pharmacokinetics*; D013607:Tablets
D013607:Tablets; D009553:Nimodipine