title: Tianeptine raises dopamine and blocks stress-induced noradrenaline release in the rat frontal cortex.
abstract: The effects of various doses of tianeptine on extracellular concentrations of dopamine were studied in the frontal cortex and nucleus accumbens of the rat. At 5 and 10 mg/kg intraperitoneally, tianeptine raised extracellular dopamine in the nucleus accumbens but only the higher dose caused a significant increase in the frontal cortex. At 10 mg/kg tianeptine significantly raised the concentrations of dihydroxyphenylacetic acid and homovanillic acid in both brain regions. In another experiment, 10 and 20 mg/kg tianeptine did not modify the extracellular concentrations of noradrenaline in the frontal cortex but dose dependently blocked the increase in extracellular noradrenaline caused by restraint stress.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sacchetti
authors.forename: I
authors.initials: I
authors.lastname: Bonini
authors.forename: G C
authors.initials: GC
authors.lastname: Waeterloos
authors.forename: R
authors.initials: R
authors.lastname: Samanin
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006719:Homovanillic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013841:Thiazepines / Q000494:pharmacology*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid