Time stability of a drug molecule sterilized through gamma rays.
In a previous work, we studied the possibility to process a drug molecule through a gamma rays sterilizing treatment. Optimal process conditions were studied and the related effects on the treated molecule were analyzed, as well. From obtained results, we concluded that there are not any contraindications to apply this sterilization process to the molecule treated. In this second paper we examined the time stability of the active ingredient treated with a gamma rays sterilization process. Among treated and untreated samples, stored in the refrigerator as well as room temperature, or slightly above, we did not observe any time-related in behaviour differences. Instead, samples stored at higher temperature (80 degrees C) showed behavioural differences between gamma treated and gamma untreated samples. This phenomenon, that at the beginning we found unexplainable, subsequently could be explained owing to further tests of "molecule stabilization" with temperature.
Matteucci
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P
Dipartimento Farmaco-Chimico Tecnologico Università di Siena.
Celletti
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P
Picello
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G
Lencioni
E
E
Franchi
G
G
D002331:Carnitine / Q000737:chemistry / Q000528:radiation effects; D004355:Drug Stability; D005720:Gamma Rays; D013242:Sterilization; D013997:Time Factors
D002331:Carnitine