A polychromatic action spectrum for photosensitivity to orally administered 8-methoxypsoralen in humans.
The action spectrum for producing minimal phototoxic erythema after oral administration of 8-methoxypsoralen (8-MOP) was determined in the range of 312-368 nm in 12 human volunteers using six different UV radiation sources. The peak sensitivity was found to be at 343 nm. The 8-MOP photosensitivity was at a high level (> or = 0.75 of maximum) between 336 and 355 nm. Conventional UVA radiation sources, like the Philips TL/09R tube, have a high energy output within 335 and 355 nm, and are therefore highly recommended in oral psoralen plus UVA radiation treatment.
Bech-Thomsen
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Department of Dermatology, Copenhagen University Hospital, Rigshospitalet, Denmark.
Wulf
H C
HC
D000284:Administration, Oral; D000328:Adult; D017484:Dermatitis, Phototoxic / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000139:chemically induced*; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011874:Radiometry / Q000295:instrumentation; D012867:Skin / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
D008730:Methoxsalen