Lytic antibody titre as a means of assessing cure after treatment of Chagas disease: a 10 years follow-up study.
A complement-mediated lysis test (CoML) using living trypomastigotes was compared with conventional serological methods and with haemoculture. Over a 10 years follow-up period evidence was obtained which supported the view that chagasic patients, treated with nitroheterocyclic drugs, in whom CoML had reverted to negative, might be considered cured despite conventional serology remaining positive.
Galvao
L M
LM
Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Nunes
R M
RM
Cançado
J R
JR
Brener
Z
Z
Krettli
A U
AU
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D014355:Chagas Disease / Q000188:drug therapy / Q000276:immunology*; D015941:Complement Hemolytic Activity Assay; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D009547:Nifurtimox / Q000627:therapeutic use; D009593:Nitroimidazoles / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000276:immunology*
D000913:Antibodies, Protozoan; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; D009547:Nifurtimox; C009999:benzonidazole