Hereditary spastic paraplegia associated with epilepsy, mental retardation and hearing impairment.
Epilepsy rarely occurs in patients with hereditary spastic paraplegia (HSP), and is not included in the description of the 'complicated' form of HSP by Harding. We report 3 patients with HSP in a family of two generations. Two of them also had epilepsy, mental retardation and hearing impairment. The disorder was inherited as an autosomal dominant trait.
Yih
J S
JS
Neurological Institute, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Wang
S J
SJ
Su
M S
MS
Tsai
S C
SC
Lin
R H
RH
Lin
K N
KN
Liu
H C
HC
D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000235:genetics; D005190:Family; D005260:Female; D006311:Hearing Disorders / Q000150:complications* / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000150:complications* / Q000235:genetics; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D015419:Spastic Paraplegia, Hereditary / Q000150:complications* / Q000235:genetics