title: The efficiency of pulmonary blood transport following single lung transplantation.
abstract: Perioperative right ventricular (RV) dysfunction remains a significant problem following single lung transplantation (SLT), especially in patients with pulmonary hypertension. Total RV power (Wt), a determinant of RV function, is the sum of the mean component (Wm) which contributes to actual blood flow and the oscillatory component (Wo) which is the energy expended on arterial pulsation. Calculation of Wo is possible only through harmonic analysis of pulmonary arterial (PA) pressure and flow waveforms, and as much as 33% of RV power is attributed to it. The purpose of this study was to precisely quantify changes in RV power output using Fourier analysis of PA pressure and flow waveforms after SLT. Fourteen dogs (donors) were instrumented with a PA ultrasonic flow probe, PA and left atrial (LA) micromanometers, and LA epicardial pacing leads. Control (Pre-Tx) pressure-flow data were acquired during transient occlusion of the right PA at a heart rate of 140. The PA was cannulated, the lungs were flushed with 1 liter of modified Euro-Collins solution at 4 degrees C, and the left lung was harvested and transplanted to 14 recipient dogs in a standard manner. After 1 hr of reperfusion, PA (Post-Tx) pressure-flow data were acquired as above. All recipient animals survived SLT with a mean ischemic time of 183 +/- 3 min. Following SLT, both the mean, Wm, (69 +/- 9 to 161 +/- 23 mW) and oscillatory, Wo, (23 +/- 3 to 46 +/- 10 mW) components of RV power output increased significantly after SLT (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: C H
authors.initials: CH
authors.lastname: Meyers
authors.forename: T A
authors.initials: TA
authors.lastname: D'Amico
authors.forename: D S
authors.initials: DS
authors.lastname: Peterseim
authors.forename: R
authors.initials: R
authors.lastname: Uppal
authors.forename: C M
authors.initials: CM
authors.lastname: Purut
authors.forename: P K
authors.initials: PK
authors.lastname: Smith
authors.forename: D C
authors.initials: DC
authors.lastname: Sabiston
authors.forename: P
authors.initials: P
authors.lastname: Van Trigt
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D005740:Gases / Q000097:blood; D016040:Lung Transplantation; D011184:Postoperative Period; D011652:Pulmonary Circulation; D016278:Ventricular Function, Right
chemical_list: D005740:Gases