title: Adrenaline-induced hypotension in neurosurgery.
abstract: We have compared the effects of scalp infiltration with 0.5% lignocaine, 0.5% lignocaine with adrenaline 1:200,000, 0.9% saline and 0.9% saline with adrenaline 1:200,000, in a prospective, randomized, double-blind study. Direct arterial pressure, heart rate and bleeding at incision were recorded in 80 patients undergoing craniotomy or craniectomy. Arterial pressure decreased by more than 20% from preinfiltration values in 40% of patients in the saline with adrenaline group, and in 55% of patients in the lignocaine with adrenaline group. It did not decrease in patients who did not receive adrenaline.
authors.affiliation: Department of Anaesthetics, Atkinson Morley's Hospital, Wimbledon, London.
authors.forename: S
authors.initials: S
authors.lastname: Phillips
authors.forename: S E
authors.initials: SE
authors.lastname: Hutchinson
authors.forename: P
authors.initials: P
authors.lastname: Bayly
authors.forename: T E
authors.initials: TE
authors.lastname: Hollway
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000601:surgery*; D003864:Depression, Chemical; D004311:Double-Blind Method; D004837:Epinephrine / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D012965:Sodium Chloride; D008012:Lidocaine; D004837:Epinephrine