[Descriptive modeling of the chemical structure-biological activity relations of a group of malonic polyethylenic acids as shown by different pharmacotoxicologic tests].
48 new polyethylenic-malonic acids have been submitted to an antimicrobial and antifungal screening. After a suitable recording, the experimental results were analyzed according to two mathematical multivariate analysis using a computer process i.e. Correspondence Factorial Analysis and Cluster Analysis. These methods allowed an accurate study of the structure of the system and a thorough investigation of the structure-activity-specificity relationships. On the other side, magnitude and/or specificity of the observed biological effects were related to structural features. These results should be useful in order to elaborate synthetic strategies.
Valla
A
A
Chimie et Biochimie des Interactions Fongiques et Microbiennes, URA 401 CNRS, Laboratoire de Chimie du Muséum National d'Histoire Naturelle, Paris, France.
Giraud
M
M
Doré
J C
JC
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008314:Malonates / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D011095:Polyethylenes / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D008314:Malonates; D011095:Polyethylenes; C030290:malonic acid
Essai de modélisation descriptive des relations structure chimique-activité biologique d'une population d'acides maloniques polyéthyléniques vis-à-vis de différents tests pharmacotoxicologiques.