title: The infusion of anti-RhO-(D) opsonized erythrocytes may be useful in the treatment of patients, splenectomized or not, with chronic, refractory autoimmune thrombocytopenic purpura--a prospective study.
abstract: Six patients with chronic refractory autoimmune thrombocytopenic purpura (ATP) were treated with five doses of autologous red blood cells (RBCs) opsonized ex vivo with anti-RhO-(D) IgG. Increases in platelet counts were observed in all cases; complete responses requiring no further treatment--for periods of 8-72 months--were recorded in four patients, three of them splenectomized. The cost of the procedure was significantly lower than other "Fc receptor (FcR) blockade" treatments.
authors.affiliation: Centro de Hematología y Medicina Interna de Puebla, México.
authors.forename: G J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
authors.forename: M G
authors.initials: MG
authors.lastname: Apreza-Molina
authors.forename: B
authors.initials: B
authors.lastname: Pérez-Romano
authors.forename: A
authors.initials: A
authors.lastname: Ruiz-Argüelles
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D016913:Blood Component Transfusion; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D013156:Splenectomy
chemical_list: D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System