A two-locus model for familial Alzheimer's disease?
The present findings for familial Alzheimer's disease suggest a possible linkage to gene(s) on chromosome 21 for the early onset form and to chromosome 19 for the late onset. Since these results are not unequivocal, possible alternative hypotheses include the effect of genetic heterogeneity or of an oligogenic model of segregation for FAD.
Macciardi
F
F
Istituto Scientifico H San Raffaele, Department of Neuroscience, University of Milano School of Medicine, Italy.
Cavallini
M C
MC
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008875:Middle Aged; D008957:Models, Genetic
D005819:Genetic Markers