title: Radioimmunoscintigraphy with technetium-99m-labelled monoclonal antibody, SM3, in gynaecological cancer.
abstract: Radioimmunoscintigraphy (RIS) with technetium-99m labelled SM3, a monoclonal antibody reacting with a polymorphic epithelial mucin glycoprotein core antigen, is evaluated. No adverse effects or thyroid uptake were observed. Studies in 45 patients (one twice) had a sensitivity for gynaecological malignancy of 100% (35/35) and a specificity of 73% (8/11), giving an overall accuracy of 93% (43/46). These results have led to the routine adoption of 99mTc RIS in the management of patients suspected of or having primary or recurrent gynaecological cancer.
authors.affiliation: Nuclear Medicine Department, St. Bartholomew's Hospital, West Smithfield, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Granowska
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
authors.forename: S J
authors.initials: SJ
authors.lastname: Mather
authors.forename: D G
authors.initials: DG
authors.lastname: Lowe
authors.forename: D
authors.initials: D
authors.lastname: Ellison
authors.forename: J
authors.initials: J
authors.lastname: Bomanji
authors.forename: J
authors.initials: J
authors.lastname: Burchell
authors.forename: J
authors.initials: J
authors.lastname: Taylor-Papadimitriou
authors.forename: C R
authors.initials: CR
authors.lastname: Hudson
authors.forename: J H
authors.initials: JH
authors.lastname: Shepherd
mesh_terms: D000328:Adult; D000368:Aged; D003536:Cystadenocarcinoma / Q000000981:diagnostic imaging; D005260:Female; D005833:Genital Neoplasms, Female / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging; D016719:Radioimmunodetection; D012680:Sensitivity and Specificity; D013667:Technetium
chemical_list: D013667:Technetium