[Extracorporeal photopheresis in the therapy of Sézary syndrome].
50 year old patient with advanced stage Sézary syndrome was treated with extracorporeal photochemotherapy. During extracorporeal photochemotherapy the photoactivable agent 8-methoxypsoralen was administered orally. After 2 h a leucocyte enriched blood fraction was irradiated with UVA extracorporeally and reinfused to the patient. Besides the extracorporeal photochemotherapy Prednisolone and Leukeran were administered. Slow but permanent improvement was observed, the erythroderma, pruritus disappeared, lymph nodes, liver, spleen enlargement reduced, the number of CD4 positive lymphocytes decreased, that of CD8 positive lymphocytes increased.
Marschalkó
M
M
Semmelweis Orvostudományi Egyetem Bör és Nemikórtani Klinika, Budapest.
Knobler
R
R
Soós
G
G
Berecz
M
M
Pálóczy
K
K
Rácz
I
I
D000284:Administration, Oral; D016913:Blood Component Transfusion; D002699:Chlorambucil / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage; D008875:Middle Aged; D010778:Photochemotherapy; D011239:Prednisolone / Q000627:therapeutic use; D012751:Sezary Syndrome / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*
D002699:Chlorambucil; D011239:Prednisolone; D008730:Methoxsalen
Extracorporalis photopheresis kezelés Sézary-syndromában.