title: Decreased hippocampal muscarinic cholinergic receptor binding measured by 123I-iododexetimide and single-photon emission computed tomography in epilepsy.
abstract: Regional binding of 123I-iododexetimide, a muscarinic acetylcholine receptor antagonist, was measured in vivo in the temporal lobes of 4 patients with complex partial seizures using single-photon emission computed tomography. In the anterior hippocampus ipsilateral to the electrical focus, 123I-iododexetimide binding was decreased by 40 +/- 9% (mean +/- SD, p < 0.01) compared with the contralateral hippocampus; 123I-iododexetimide binding in other temporal lobe regions was symmetrical. The data indicate a regionally specific change of muscarinic acetylcholine receptor in anterior hippocampus in complex partial seizures of temporal lobe origin.
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: H W
authors.initials: HW
authors.lastname: Müller-Gärtner
authors.forename: H S
authors.initials: HS
authors.lastname: Mayberg
authors.forename: R S
authors.initials: RS
authors.lastname: Fisher
authors.forename: R P
authors.initials: RP
authors.lastname: Lesser
authors.forename: A A
authors.initials: AA
authors.lastname: Wilson
authors.forename: H T
authors.initials: HT
authors.lastname: Ravert
authors.forename: R F
authors.initials: RF
authors.lastname: Dannals
authors.forename: H N
authors.initials: HN
authors.lastname: Wagner
authors.forename: S
authors.initials: S
authors.lastname: Uematsu
authors.forename: J J
authors.initials: JJ
authors.lastname: Frost
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003909:Dexetimide / Q000031:analogs & derivatives* / Q000378:metabolism; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011976:Receptors, Muscarinic / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D011976:Receptors, Muscarinic; C066812:4-iododexetimide; D003909:Dexetimide