Cloning of the gene encoding Streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence.
Streptococcin A-FF22 (SA-FF22) is a lantibiotic produced by Streptococcus pyogenes FF22. The nucleotide sequence of the SA-FF22 structural gene (scnA) was determined and shown to encode a 51-amino-acid prepeptide. The proteolytic processing site of the SA-FF22 prepeptide differs from that which characterizes other type A lantibiotics.
Hynes
W L
WL
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Ferretti
J J
JJ
Tagg
J R
JR
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D017353:Gene Deletion; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics; D010957:Plasmids; D013297:Streptococcus pyogenes / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D004269:DNA, Bacterial; D010455:Peptides; C016887:A-FF22