[Creation of monoclonal antibodies against tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor alpha (TFG-alpha), their definition and possible use].
These antibodies were characterised immunoserologically and immunohistochemically. The antibodies proved suitable in the detection of TNF-alpha and TGF-alpha production by different cells and tissues. These anti-TNF-alpha specific monoclonal antibodies were able to inhibit the cytotoxic effect of hrTNF-alpha in vitro. These monoclonal antibodies may potentially be useful in the future for determining TNF-alpha or TGF-alpha level by different immunodiagnostical assays (ELISA, RIA, FIA) in the medical practice.
Bebök
Z
Z
Pécsi Orvostudományi Egyetem, Immunológiai és Biotechnológiai Laboratórium.
Szekeres
G
G
Horváth
G
G
Duda
E
E
Németh
P
P
D000911:Antibodies, Monoclonal / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006825:Hybridomas / Q000378:metabolism; D007150:Immunohistochemistry; D016211:Transforming Growth Factor alpha / Q000032:analysis* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D016211:Transforming Growth Factor alpha; D014409:Tumor Necrosis Factor-alpha
Tumor necrosis factor alfa (TNF-alpha) és transforming growth factor alfa (TGF-alpha) elleni monoklonális ellenanyagok elöállítása, jellemzése és felhasználásuk lehetöségei.