[The effect of alpha-tocopherol and nicotinamide on lipid peroxidation and the activity of the antioxidant system in the lung tissue of premature rat pups].
The antenatal use of nicotinamide and especially alpha-tocopherol in the experiments with premature newborn rats caused a significant decrease in the rate of lipid peroxidation and an increase in catalase activity both in the maternal body and in fetal lung tissue. It is suggested that the drugs can be used to prevent the development of membrane-destructive processes in the fetal and neonatal lung.
Nadzhimutdinov
K N
KN
Mavlianov
I R
IR
Umarov
E F
EF
Mutalov
N K
NK
D000653:Amniotic Fluid / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D014810:Vitamin E; D009536:Niacinamide
Vliianie al'fa-tokoferola i nikotinamida na perekisnoe okislenie lipidov i aktivnost' antioksidantnoĭ sistemy v legochnoĭ tkani nedonoshennykh krysiat.