title: [Complications in pre- versus intraoperative one-time prophylaxis with cefuroxime after biliary surgery].
abstract: The trial was conducted with 66 patients undergoing cholecystectomy. At random, 33 patients received 1.5 g cefuroxime i.v. as a single bolus 20 minutes before surgical incision and 33 patients were injected 20 minutes after incision. The overall incidence of wound infections was 1.51%. In the preoperative group, there was the one wound infection and two patients developed urinary tract infections (incidence of infectious complications 9.1%). In the intraoperative group, one patient developed pneumonia and urinary tract infection and another had urinary tract infection. Wound infections did not occur in this group (incidence of infectious complications 6.1%). Patients with infectious complications had a longer operation time and a longer hospital stay. In conclusion, there was no statistically significant difference in infectious complications when cefuroxime prophylaxis was given preoperatively compared to intraoperative administration.
authors.affiliation: Arzt für Chirurgie, Mettmann.
authors.forename: F
authors.initials: F
authors.lastname: Neidel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000517:prevention & control*; D002444:Cefuroxime / Q000008:administration & dosage / Q000627:therapeutic use*; D002763:Cholecystectomy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control; D014552:Urinary Tract Infections / Q000517:prevention & control
chemical_list: D002444:Cefuroxime
vernacular_title: Komplikationen bei prä- versus intraoperativer Einmalprophylaxe mit Cefuroxim nach Gallenoperationen.