title: [Immunologic studies of barbiturates--the effect of structural characteristics on cross-reactivity].
abstract: Immunologic assay methods are widely used in chemico-toxicological analysis. Often test kits that are created for the detection of entire drug groups, e.g. barbiturates, are put into action. Within a drug-group the extent of the reaction with the test antiserum, the cross-reactivity, varies considerably. The influence of molecular structures on the cross-reactivity is examined for the ADX-test kit for the detection of barbiturates from urine. In order to obtain a result equal to or exceeding the threshold value (200 ng/ml secobarbital-equivalents) high barbiturate concentrations in urine are required in some cases.
authors.affiliation: Landesuntersuchungsinstitut für Lebensmittel, Arzneimittel und Tierseuchen Berlin.
authors.forename: K H
authors.initials: KH
authors.lastname: Beyer
authors.forename: A
authors.initials: A
authors.lastname: Droste
mesh_terms: D000918:Antibody Specificity; D001463:Barbiturates / Q000737:chemistry / Q000276:immunology* / Q000652:urine; D003429:Cross Reactions; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D007118:Immunoassay; D011933:Reagent Kits, Diagnostic
chemical_list: D001463:Barbiturates; D011933:Reagent Kits, Diagnostic
vernacular_title: Immunologische Untersuchungen auf Barbiturate--Der Einfluss von Strukturmerkmalen auf die Kreuzreaktivität.