Plasma fluphenazine levels measured by high-performance liquid chromatography in patients treated with depot injections.
Fluphenazine (CAS 69-23-8) concentrations in plasma of schizophrenic patients after oral (fluphenazine hydrochloride, Moditen) or intramuscular (fluphenazine enanthate, Moditen Retard, or fluphenazine decanoate, Modecate) administration of drug were measured by means of high-performance liquid chromatography. The extracted compound was identified by gas chromatography with mass selective detector. Pharmacokinetics of fluphenazine has been studied.
Jouen
F
F
Centre Hospitalier Spécialisé du Rouvray, Sotteville-lès-Rouen, France.
Verité
P
P
André
D
D
Colonna
L
L
Boucly
P
P
D001800:Blood Specimen Collection; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D005476:Fluphenazine / Q000008:administration & dosage / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D001523:Mental Disorders / Q000097:blood
D003692:Delayed-Action Preparations; D007202:Indicators and Reagents; D005476:Fluphenazine