Glutamine in parenteral solutions enhances intestinal mucosal immune function in rats.
Biliary secretory immunoglobulin A (sIgA) and proportions of IgA+ plasma cells, helper T cells, and suppressor/cytotoxic T cells in intestinal tissue were lower in rats receiving a standard total parenteral nutrition (TPN) solution than in those receiving TPN enriched with glutamine. Parenteral solutions supplemented with glutamine may preserve the ability of intestinal immune tissue to produce sIgA-synthesizing plasma cells following antigenic stimulation.
D000818:Animals; D005973:Glutamine / Q000494:pharmacology*; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D010289:Parenteral Nutrition, Total; D051381:Rats; D011916:Rats, Inbred F344
D007071:Immunoglobulin A, Secretory; D007075:Immunoglobulin M; D005973:Glutamine