title: Terminal transverse limb defects and early chorionic villus sampling: evaluation of 4,300 cases with completed follow-up.
abstract: Data from 4,300 consecutive cases following prenatal diagnosis by transcervical (TC) CVS (n = 1,570) and transabdominal (TA) CVS (n = 2,370) were evaluated. In the follow-up study only infants examined by a physician were included. Gestational age varied between 8.5 and 11.6 weeks (mean 10.3 weeks) for TC-CVS and between 9.3 and 20 weeks (mean 12.3 weeks) for TA-CVS 98% of TC-CVS was performed at 9-10 weeks, 80.7% of TA-CVS procedures were carried out at 12-15 weeks. Selective termination took place in 97 cases of TC-CVS (6.1%) and in 72 cases of TA-CVS (2.6%). Another 8 women had a termination for psychosocial reasons, resulting in 4,123 (1,469 TC, 2,654 TA) continuing pregnancies. The overall fetal loss rate < 28 weeks was 5.4% (n = 80) for TC-CVS and 2.6% (n = 70) for TA-CVS. The overall incidence of congenital abnormalities after birth was 0.9%. Two terminal transversal limb defects were detected in the TC-CVS group (0.14%) against one (0.04%) in the TA-CVS group.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.
authors.forename: M G
authors.initials: MG
authors.lastname: Jahoda
authors.forename: H
authors.initials: H
authors.lastname: Brandenburg
authors.forename: T
authors.initials: T
authors.lastname: Cohen-Overbeek
authors.forename: F J
authors.initials: FJ
authors.lastname: Los
authors.forename: E S
authors.initials: ES
authors.lastname: Sachs
authors.forename: J W
authors.initials: JW
authors.lastname: Wladimiroff
mesh_terms: D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D005532:Foot Deformities, Congenital / Q000209:etiology*; D005865:Gestational Age; D006228:Hand Deformities, Congenital / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011261:Pregnancy Trimester, First