Chromosomal mapping of the human interleukin-1 receptor antagonist gene (IL-1RN) and isolation of specific YAC clones.
Using a panel of somatic rodent-human cell hybrids, we show that the interleukin-1 receptor antagonist gene (IL-1RN) maps to the long arm of human chromosome 2. Linkage studies permitted the regional localization of this gene to band q14-21. This is the same region in which the IL-1 alpha and IL-1 beta genes are localized. Three yeast artificial chromosome (YAC) clones containing the IL-1RN gene were isolated, and these will be used for further characterization of this chromosome 2 region.
Steinkasserer
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A
MRC Immunochemistry Unit, Dept. Biochemistry, Oxford, UK.
Spurr
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NK
Sim
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RB
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods; D002889:Chromosomes, Human, Pair 2 / Q000737:chemistry*; D003001:Cloning, Molecular; D006801:Humans; D006822:Hybrid Cells; D053590:Interleukin 1 Receptor Antagonist Protein; D008969:Molecular Sequence Data; D051381:Rats; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors* / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D012795:Sialoglycoproteins / Q000235:genetics*
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins