title: Continuous chemotherapy in responsive metastatic breast cancer: a role for tumour markers?
abstract: A biochemical response index comprising ESR, CEA and CA 15.3 was evaluated in 67 patients with systemic breast cancer treated by chemotherapy; 55 were assessable by UICC criteria and the response index (96% of all UICC assessable patients). Marker changes at 2 and 4 months showed a highly significant correlation with the UICC assessed response at 3 and 6 months (P < 0.001); sensitivity 100%, specificity 87%; positive predictive value 85%; negative predictive value 100%. This index was then used to select out truly responsive patients and to prospectively direct their chemotherapy. Twenty-six responding (biochemical/clinical) patients were randomised to discontinue cytotoxics after 6 months and move to maintenance hormones (n = 13) or continue chemotherapy whilst the biochemical markers kept falling or remained within the normal range. Biochemical progression prompted a change of chemotherapy. Continuous chemotherapy in biochemically defined responders was associated with a significant lengthening of remission duration and an improved quality of life and survival. We are now using the index to routinely direct chemotherapy and select out true responders for maintenance chemotherapy.
authors.affiliation: City Hospital, Nottingham, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Dixon
authors.forename: L
authors.initials: L
authors.lastname: Jackson
authors.forename: S Y
authors.initials: SY
authors.lastname: Chan
authors.forename: R A
authors.initials: RA
authors.lastname: Badley
authors.forename: R W
authors.initials: RW
authors.lastname: Blamey
mesh_terms: D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood*; D001799:Blood Sedimentation / Q000187:drug effects; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D002272:Carcinoembryonic Antigen / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D011960:Receptors, Estrogen / Q000032:analysis; D013997:Time Factors
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D011933:Reagent Kits, Diagnostic; D011960:Receptors, Estrogen; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate