title: Neoadjuvant chemotherapy with cisplatin and 5-fluorouracil, both in continuous 96-hour infusion, in the treatment of locally advanced head and neck cancer.
abstract: In this study, 79 patients with locally advanced head and neck cancer were treated with induction chemotherapy. Cisplatin, 25 mg/m2, and 5-fluorouracil (5-FU), 1000 mg/m2, were employed, both of them in 24-hour continuous infusion over 96 hours, four cycles. The patients later underwent surgery and/or radiation therapy. The response to chemotherapy was 49%: of the complete responses (CR), 56% were histological; 29% were partial responses (PR). With the administration of the fourth cycle, CR increased from 30% to 49%. Once the complete treatment had been finished, 75% of CR and 5% PR were achieved. With a maximum follow-up period of 44 months, overall survival stands at 50%.
authors.affiliation: Department of Oncology, Otolaryngology, Hospital Clinico Universitario, Salamanca, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fonseca
authors.forename: J J
authors.initials: JJ
authors.lastname: Cruz
authors.forename: A
authors.initials: A
authors.lastname: Gomez
authors.forename: P
authors.initials: P
authors.lastname: Sanchez
authors.forename: G
authors.initials: G
authors.lastname: Martin
authors.forename: P
authors.initials: P
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: A
authors.initials: A
authors.lastname: Nieto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil