Specific increase of genetic expression of parvalbumin in fast skeletal muscles of mdx mice.
Parvalbumin mRNA was assayed by Northern blot analysis in muscles from normal and dystropic (mdx) mice. Its content was found to be specifically higher in mdx fast muscles than in control preparations. This suggests an increased expression of the protein in dystrophin-lacking fast fibres. A possible role in calcium homeostasis is discussed.
Gailly
P
P
Department of Physiology, Catholic University of Louvain, Brussels, Belgium.
Hermans
E
E
Octave
J N
JN
Gillis
J M
JM
D000199:Actins / Q000235:genetics; D000818:Animals; D015152:Blotting, Northern; D002118:Calcium / Q000378:metabolism; D015342:DNA Probes; D015870:Gene Expression; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D009132:Muscles / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010320:Parvalbumins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism
D000199:Actins; D015342:DNA Probes; D010320:Parvalbumins; D012333:RNA, Messenger; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D002118:Calcium