title: Application of the ICRU Report 38 reference volume concept to the radiotherapeutic management of recurrent endometrial and cervical carcinoma.
abstract: Radiation therapy was given to 25 patients presenting with pelvic recurrence of endometrial (14) and cervical (11) cancer. Of these patients, all but one had undergone hysterectomy following their original diagnosis. Two endometrial patients received preoperative intracavitary irradiation. The recurrence-free interval ranged from 5 to 71 months (mean = 21 months). External beam radiation therapy for pelvic recurrence ranged from 3000 to 5000 cGy. Additional central radiation was given to 18 patients with either external beam, intracavitary, interstitial, or transvaginal technique. Dose and dose rates from brachytherapy are documented with maximum values, along with the location of these dose points. Such specification is essential in obtaining a more accurate impression of the total dose delivered to the patient, especially when different techniques are employed to increase the dose to the center of the pelvis. Reference volume dimensions, similar to those specified by ICRU Report 38 for intracavitary treatments, are presented. Mean follow-up from completion to radiotherapy is 22 months; 16 patients are dead, 2 are alive with disease, and 7 are alive with no evidence of disease.
authors.affiliation: Department of Radiation Oncology, Southern California Permanente Medical Group, Los Angeles 90027.
authors.forename: J E
authors.initials: JE
authors.lastname: Bellotti
authors.forename: A R
authors.initials: AR
authors.lastname: Kagan
authors.forename: M
authors.initials: M
authors.lastname: Wollin
authors.forename: A
authors.initials: A
authors.lastname: Olch
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D016889:Endometrial Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012007:Rectum / Q000528:radiation effects; D016879:Salvage Therapy; D015996:Survival Rate; D001743:Urinary Bladder / Q000528:radiation effects; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy* / Q000601:surgery