Effect of positive family history of hypertension on the blood pressure and catecholamine responses to a 6 hour adrenaline infusion.
1. The effects of 6 h infusion of adrenaline (INF-A) or dextrose (INF-D) and of post-infusion cold pressor test (CPT) were compared in normal subjects, with (FH+) and without (FH-) a family history of hypertension. 2. Increased urinary excretion rates suggested facilitated noradrenaline (NA) release during and after INF-A in both FH+ and FH-. 3. Urinary adrenaline (UADR) excretion increased during INF-A, as expected, and was also slightly higher after INF-A than INF-D. 4. The effect of INF-A on systolic blood pressure (SBP) was greater in FH- than in FH+ but diastolic blood pressure (DBP) did not fall as quickly with nocturnal recumbency after INF-A in FH+. 5. A significantly greater response in plasma NA to CPT was seen in FH+ than in FH- after INF-A. A similar trend was also seen after INF-D. 6. Increases in DBP due to CPT were higher in FH+ than in FH- after both infusions. 7. This study provides evidence of increased noradrenergic activity during and after INF-A, and also of a difference in response to sympathetic stimulation between FH+ and FH-.
Bachmann
A W
AW
University of Queensland, Department of Medicine, Greenslopes Hospital, Brisbane, Australia.
Ballantine
D M
DM
Gordon
R D
RD
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004837:Epinephrine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000097:blood* / Q000652:urine
D005947:Glucose; D009638:Norepinephrine; D004837:Epinephrine