[Histology of retinal lesions after continuous irradiation and selective micro-coagulation of the retinal pigment epithelium].
Mild continuous wave (CW) irradiation (100 ms, 20 mW, 514 nm) and irradiation with 100 repetitive 5 microseconds laser pulses (3 or 6 microJ, 514 nm) at a repetition rate of 500 Hz was performed to the regio macularis of chinchilla rabbits. The angiographically visible lesions were histologically followed up to 4 weeks. With both irradiation modalities the original retinal pigment epithelium (RPE) was replaced by a monolayer of new RPE cells. Only minimal immediate and no subsequent damage to the photoreceptors was found after selective RPE photocoagulation. Only minimal inflammatory response was found after selective RPE photocoagulation in contrast to CW photocoagulation where macrophages, RPE cells and lymphocytes regularly appear in the damaged photoreceptor layer.
Roider
J
J
Wellman Laboratories of Photomedicine, Harvard Medical School, Boston.
Michaud
N
N
Flotte
T
T
Birngruber
R
R
D000818:Animals; D017075:Laser Coagulation / Q000295:instrumentation*; D008028:Light Coagulation / Q000295:instrumentation*; D008855:Microscopy, Electron, Scanning; D008866:Microsurgery / Q000295:instrumentation*; D010786:Photoreceptor Cells / Q000293:injuries / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D012038:Regeneration / Q000502:physiology; D012160:Retina / Q000293:injuries* / Q000473:pathology; D014945:Wound Healing / Q000502:physiology
Histologie von Netzhautläsionen nach kontinuierlicher Bestrahlung und nach selektiver Mikrokoagulation des retinalen Pigmentepithels.