title: Increased depth of trophoblast invasion after chronic constriction of the lower aorta in rhesus monkeys.
abstract: OBJECTIVE
  Our purpose was to investigate whether a reduction in uteroplacental perfusion pressure would produce changes in trophoblast-uterine interactions at the cellular level.
  
  
  METHODS
  Strictures were placed around the abdominal aortas of rhesus monkeys at 116 +/- 7 days of pregnancy to reduce uteroplacental perfusion pressure. Placental bed biopsy specimens were obtained at cesarean section, and cytotrophoblasts were identified by means of an anticytokeratin antibody.
  
  
  RESULTS
  In monkeys without aortic strictures, interstitial trophoblast invasion was restricted to the outer half of the endometrium. Endovascular trophoblast invasion involved the entire endometrial portion of uterine vessels and extended through the subjacent half of their myometrial segments. In seven of nine monkeys with aortic strictures the depth of interstitial trophoblast invasion was substantially increased and extended throughout the entire decidua and at least a portion of the myometrium. In contrast, the pattern of endovascular trophoblast invasion was identical to that observed in the placental beds of control animals.
  
  
  CONCLUSIONS
  These results suggest that uteroplacental perfusion pressure or oxygen content may be important physiologic factors controlling the depth of interstitial cytotrophoblast invasion.
authors.affiliation: Department of Stomatology, University of California, San Francisco 94143-0512.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: K
authors.initials: K
authors.lastname: Chiu
authors.forename: R J
authors.initials: RJ
authors.lastname: Brescia
authors.forename: C A
authors.initials: CA
authors.lastname: Combs
authors.forename: M A
authors.initials: MA
authors.lastname: Katz
authors.forename: J L
authors.initials: JL
authors.lastname: Kitzmiller
authors.forename: D C
authors.initials: DC
authors.lastname: Heilbron
authors.forename: S J
authors.initials: SJ
authors.lastname: Fisher
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure; D001808:Blood Vessels / Q000166:cytology; D002465:Cell Movement; D003250:Constriction; D004717:Endometrium / Q000166:cytology; D005260:Female; D007124:Immunoenzyme Techniques; D008253:Macaca mulatta; D008863:Microspheres; D009215:Myometrium / Q000166:cytology; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology / Q000502:physiology*; D014599:Uterus / Q000098:blood supply / Q000166:cytology