[Positive and negative controls on hematopoietic progenitor development: models and facts].
The stochastic model of stem cell differentiation is in accord with experimental findings but does not explain hematopoietic homeostasis. We discuss how positive and negative controls by cytokines and inhibitors could maintain homeostasis, even though progenitor commitment towards the various hematopoietic lineages may be stochastic.
Panterne
B
B
Laboratoire CNRS de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, UPR 272, IRSC, Villejuif, France.
Hatzfeld
A
A
Zhou
Y Q
YQ
Li
M L
ML
Sansilvestri
P
P
Cardoso
A
A
Lévesque
J P
JP
Ginsbourg
M
M
Batard
P
P
Kiselev
S
S
D002454:Cell Differentiation / Q000502:physiology; D003115:Colony-Stimulating Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D013269:Stochastic Processes
D003115:Colony-Stimulating Factors
Contrôles positifs et négatifs du développement des progéniteurs hématopoïétiques: modèles et faits.