title: Inhibition of wound contraction by topical antimicrobials.
abstract: Spontaneous wound healing occurs partly by wound contraction, a process that requires intact functioning fibroblasts, and collagen production. Disruption of fibroblasts by the topical antimicrobials, silver sulfadiazine and mafenide acetate has been demonstrated in vitro. An acute rat wound model was used to show that wound contraction in vivo is significantly impeded by silver sulfadiazine and mafenide acetate.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital, Australia.
authors.forename: I O
authors.initials: IO
authors.lastname: Leitch
authors.forename: A
authors.initials: A
authors.lastname: Kucukcelebi
authors.forename: M C
authors.initials: MC
authors.lastname: Robson
mesh_terms: D000287:Administration, Topical; D000336:Aerosols / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001706:Biopsy; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003094:Collagen / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D008272:Mafenide / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012837:Silver Sulfadiazine / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology
chemical_list: D000336:Aerosols; D004338:Drug Combinations; D008272:Mafenide; D003094:Collagen; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; D012837:Silver Sulfadiazine