Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus.
OBJECTIVE
To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE).


METHODS
TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects.


RESULTS
No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgroup of SLE. Furthermore, there was no evidence for significant linkage disequilibrium between TAP2 and HLA-DQ/DR in SLE.


CONCLUSIONS
These data suggest that TAP2 is not a disease susceptibility gene for SLE and that the disease-predisposing haplotypes do not extend as far as TAP2. This indicates that any HLA-DP association with SLE must be independent of other class II (DQ/DR) associations.
Davies
E J
EJ
University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford.
Donn
R P
RP
Hillarby
M C
MC
Grennan
D M
DM
Ollier
W E
WE
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics*; D004198:Disease Susceptibility; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D000949:Histocompatibility Antigens Class II; C071692:TAP2 protein, human