title: Experience with cost-effective in-house reagents for the assay of carbamazepine in serum, using the Abbott TDx.
abstract: The development of inexpensive in-house reagents for the assay of carbamazepine in serum, using a commercially available derivative and antiserum is described. They were adapted for use on the Abbott TDx as direct replacements for commercial reagents. Comparison with a high-performance liquid chromatography method is discussed together with an evaluation of their performance in an external quality control scheme. They proved robust and reliable and reagent costs were reduced to around 3p per test.
authors.affiliation: Department of Chemical Pathology, Medical College of St. Bartholomew's Hospital, London, England.
authors.forename: D L
authors.initials: DL
authors.lastname: Colbert
authors.forename: G J
authors.initials: GJ
authors.lastname: Turner
mesh_terms: D002220:Carbamazepine / Q000097:blood*; D002624:Chemistry, Clinical / Q000191:economics / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003362:Cost-Benefit Analysis; D003429:Cross Reactions; D004355:Drug Stability; D006801:Humans; D011786:Quality Control; D011933:Reagent Kits, Diagnostic / Q000191:economics*
chemical_list: D011933:Reagent Kits, Diagnostic; D002220:Carbamazepine