Lipid peroxidation in brain tissue of newborn rats derived from two models of disturbed pregnancy.
Two models of disturbed pregnancy, both causing decreased fetal body mass, were used: the endotoxin-model (treatment of pregnant rats with heat-denaturated bacterial material) and the stress-model (chronic restraint of prenatally lithium-treated pregnant dams). Fetuses were delivered by Caesarean section in the morning of the 21st gestational day. After disturbed pregnancy lipid peroxidation (iron-stimulated formation of thiobarbituric acid reagible substances) was not changed in 9,000 g supernatant of total brain. The values of all groups were higher after determination in frozen/thawed tissue in comparison to freshly prepared material. The results do not indicate an enhanced vulnerability of brain tissue after both models of disturbed pregnancy.
Glöckner
R
R
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D015227:Lipid Peroxidation; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar