Adenoma residua in colorectal cancer. A study of 34 colorectal cancers detected by an immunological occult blood test.
A retrospective histological study was made searching for adenoma remnants in 34 colorectal cancer specimens detected by the quantitative and human Hb-specific immunological FECA-EIA test for occult blood in the faeces. As a control group, 34 colorectal cancer preparations from routine hospital material were studied in a similar manner. A difference was found between these materials, 12 out of 34 study cancers showing adenoma residua compared with only two in the control group. Even if a proportion of colorectal cancers is apparently not associated with adenomas, it is suggested that the existence of adenoma remnants is a sign of biologically early tumour development and consequently, it might correlate with a favourable prognosis.
Häkkinen
I
I
Department of Surgery, University Central Hospital, Turku, Finland.
Järvi
O
O
Nylamo
E
E
Söderström
K O
KO
D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003111:Colonic Polyps / Q000473:pathology* / Q000601:surgery; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009780:Occult Blood