title: Pulmonary hemorrhage due to inhalation of vapor containing pyromellitic dianhydride.
abstract: Pulmonary hemorrhage due to inhalation of fumes or powders containing trimellitic anhydride (TMA) is well known. We report pulmonary hemorrhage in a young man exposed to epoxy resin vapor containing pyromellitic dianhydride (PMDA). Serum IgG antibodies to PMDA could be detected. We conclude that the pulmonary hemorrhage was mediated by a reaction to PMDA in analogy to the TMA-induced disease. We suggest that exposure to any acid anhydride should be considered a possible cause of pulmonary hemorrhage since these compounds share structural and functional similarities.
authors.affiliation: Department of Internal Medicine, University Hospital of Zürich, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Kaplan
authors.forename: X
authors.initials: X
authors.lastname: Baur
authors.forename: A
authors.initials: A
authors.lastname: Czuppon
authors.forename: M
authors.initials: M
authors.lastname: Ruegger
authors.forename: E
authors.initials: E
authors.lastname: Russi
authors.forename: R
authors.initials: R
authors.lastname: Speich
mesh_terms: D000293:Adolescent; D001565:Benzoates / Q000009:adverse effects*; D006470:Hemorrhage / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography
chemical_list: D001565:Benzoates; C012019:pyromellitic dianhydride