Chronic lymphocytic leukemia associated with bone marrow fibrosis: possible role of interleukin 1 alpha in the pathogenesis.
B-cell chronic lymphocytic leukemia (B-CLL) associated with bone marrow fibrosis is described. The conditioned medium of the CLL cells contained a high quantity of interleukin 1 alpha (IL-1 alpha), and showed growth promoting activity for marrow fibroblasts which was partially inhibited by anti IL-1 alpha antibody. In addition, the conditioned medium as well as IL-1 alpha stimulated the growth of marrow fibroblasts from the patient. These results strongly suggested the marrow fibrosis occurred by the secretion of IL-1 alpha from the CLL cells and its growth stimulation of marrow fibroblasts. As far as we know, this is the first case in which B-CLL was associated with marrow fibrosis, and its mechanism was investigated.
Kimura
A
A
Department of Internal Medicine, Hiroshima University, Japan.
Hyodo
H
H
Nakata
Y
Y
Kuramoto
A
A
D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002455:Cell Division; D002478:Cells, Cultured; D002699:Chlorambucil / Q000627:therapeutic use; D017077:Culture Media, Conditioned; D003520:Cyclophosphamide / Q000008:administration & dosage; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D055728:Primary Myelofibrosis / Q000209:etiology / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
D015703:Antigens, CD; D017077:Culture Media, Conditioned; D007375:Interleukin-1; D002699:Chlorambucil; D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone