title: An immunohistochemical study of bone morphogenetic protein in pleomorphic adenoma of the salivary gland.
abstract: Bone morphogenetic protein (BMP) is a potent induction factor for new bone formation including heterotopic chondro-ossification in soft tissues. The immunohistochemical reaction for BMP was studied in 23 cases of pleomorphic adenoma of salivary gland by using a monoclonal antibody produced by hybridoma technique. Positive BMP immunoreactivity was seen in 87% of tumours. Immunohistochemical expression of BMP was observed in modified myoepithelial cells (88% cases), luminal tumour cells of tubulo-ductal structures (78% cases) and chondroid cells in hyaline tissue (22% cases). The authors concluded that the simultaneous presence of glycosaminoglycans as matrix substance with BMP-mediated cellular activity of modified myoepithelial cells in the formation of chondroid structures in pleomorphic adenomas of the salivary glands.
authors.affiliation: Department of Oral Pathology, Stomatological College of the Fourth Military Medical University, Xi'an, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lianjia
authors.forename: J
authors.initials: J
authors.lastname: Yan
authors.forename: N
authors.initials: N
authors.lastname: Hitoshi
authors.forename: S
authors.initials: S
authors.lastname: Shinichiro
authors.forename: K
authors.initials: K
authors.lastname: Akihide
authors.forename: M
authors.initials: M
authors.lastname: Masahiko
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D019485:Bone Morphogenetic Proteins; D006801:Humans; D007150:Immunohistochemistry; D011506:Proteins / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D019485:Bone Morphogenetic Proteins; D011506:Proteins; D009418:S100 Proteins