A comparison of induced heat-shock protein in neurons destined to survive and those destined to die after transient ischemia in rats.
We examined the induction of heat-shock protein (HSP) in CA-1 pyramidal neurons compared with that in CA-3 pyramidal neurons, in rat brain following 20 min of ischemia. The time course of the changes of localization of HSP was investigated using immunohistochemical and Western blot analyses. The induction of HSP in the CA-1 subfield was the same as that in the surviving hippocampal CA-3 subfield.
Tomioka
C
C
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Nishioka
K
K
Kogure
K
K
D000818:Animals; D015153:Blotting, Western; D016923:Cell Death / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D011712:Pyramidal Tracts / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar
D006360:Heat-Shock Proteins