Amyloid deposition in Alzheimer's disease.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, accounts for approximately 60 percent of all victims of dementia and affects greater than 10 percent of the population over 65 years old. Although the cause is unknown, there is evidence that beta-amyloid plays an important role in its pathogenesis. The deposition of this type of amyloid in the brain and its implications in AD are discussed.
Meena-Leist
C E
CE
Department of Pathology, University of Louisville School of Medicine, Kentucky 40292.
Parker
J C
JC
D000368:Aged; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006801:Humans
D016229:Amyloid beta-Peptides