The middle-Norway eye-screening study. III. The prevalence of capsular glaucoma is influenced by blood-group antigens.
The association between blood groups (ABO, Rh, Kell, Duffy) and pseudo-exfoliation syndrome, simple, and capsular glaucoma have been evaluated. The findings were: 1). No statistically significant abnormalities regarding blood group distribution in persons with pseudo-exfoliation syndrome. 2). In contrast to simple glaucoma, capsular glaucoma showed an abnormal distribution in the ABO- and the Kell-system. There was less glaucoma prevalence in the capsular A1-group compared to the O-group (p = 0.013), and less in the K1 negative group compared to the K1 positive one (p = 0.005). This trend was even escalated when combining the two systems: Among the K1 negative persons the glaucoma prevalence was lower in the A1-group compared to the O-group (p = 0.003). In the K1 negative group only 9 of 61 A1-persons developed glaucoma, in contrast to the K1 positive group where 4 of 4 A1-persons had glaucoma. This difference gave p < or = 0.00038, whereas the corresponding difference for the O-groups showed p = 0.65. It is concluded that once a person with blood group A1 has developed pseudo-exfoliation syndrome, the risk that capsular glaucoma will occur is about 7 times higher when that person is K1 positive compared to K1 negative. Perhaps this observation may be used as a prognostic factor for non-glaucomatous PE positive persons.
Ringvold
A
A
University Eye Department, Ullevål Hospital, Oslo, Norway.
Blika
S
S
Elsås
T
T
Guldahl
J
J
Juel
E
E
Brevik
T
T
Hesstvedt
P
P
Hoff
K
K
Høisen
H
H
Kjørsvik
S
S
D000368:Aged; D000869:Anterior Eye Segment; D001789:Blood Group Antigens / Q000032:analysis*; D001788:Blood Grouping and Crossmatching; D005128:Eye Diseases / Q000097:blood*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D009664:Norway / Q000453:epidemiology; D015995:Prevalence; D015351:Vision Screening
D001789:Blood Group Antigens