title: Transfusion associated AIDS in Mexico. Clinical spectrum, conditional latency distribution, and survival.
abstract: There is very little information on the clinical spectrum and the incubation period among AIDS patients in Latin America. This study reports the clinical spectrum, survival, and the incubation period for a group of Mexican patients infected with HIV-1 as a result of contaminated blood transfusion. We analyzed data from 39 patients of whom date of transfusion and diagnosis were known. The clinical spectrum of the disease was compared with a group of AIDS Mexican patients infected by sexual route. The prevalence distribution of opportunistic infections was similar in both groups. However, there was a significant difference in the distribution of opportunistic malignancies, i.e., Kaposi's sarcoma was observed only in the homosexual group. AIDS developed within 48 months after infection (3% within 12 months after transfusion, 50% within 29 months, 75% within 36 months, and the remaining within four years). The mean survival was of nine months after AIDS is made, the survival in this group of AIDS Mexican patients was similar to that observed in other HIV-1 exposed risk groups in Mexico. These findings suggest that the route of exposure to HIV-1 may have prognostic implications in the natural history of this infection in the Mexican population.
authors.affiliation: Department of Infectious Diseases, Instituto Nacional de Cancerología, México, D.F.
authors.forename: P
authors.initials: P
authors.lastname: Volkow
authors.forename: S
authors.initials: S
authors.lastname: Ponce de León
authors.forename: J
authors.initials: J
authors.lastname: Calva
authors.forename: G
authors.initials: G
authors.lastname: Ruiz-Palacios
authors.forename: A
authors.initials: A
authors.lastname: Mohar
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology* / Q000635:transmission; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015993:Life Tables; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors; D065227:Transfusion Reaction