title: Needling revision of failed filtering blebs with adjunctive 5-fluorouracil.
abstract: We investigated the outcome of needling revision with adjunctive subconjunctival 5-fluorouracil (5-FU) performed on 30 eyes of 30 consecutive glaucoma patients with failed filtering blebs 49.0 +/- 65.4 weeks after trabeculectomy. Follow up was 67.3 +/- 22.8 weeks from the time of the first needling revision and 49.9 +/- 26.2 weeks from the last needling procedure. Twenty-four (80%) of the eyes were treatment successes after 2.6 +/- 1.9 needling revisions, with a mean intraocular pressure (IOP) of 13.9 +/- 3.7 mm Hg on 1.5 +/- 1.1 medications, a significantly lower mean IOP and number of medications than before the procedure (32.5 +/- 7.8 mm Hg on 1.7 +/- 1.5 medications [P < .001, paired t-test]). Needling revision with adjunctive 5-FU appears to be a safe and effective means of reestablishing filtration.
authors.affiliation: Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Mich 48092.
authors.forename: D H
authors.initials: DH
authors.lastname: Shin
authors.forename: M S
authors.initials: MS
authors.lastname: Juzych
authors.forename: A K
authors.initials: AK
authors.lastname: Khatana
authors.forename: R P
authors.initials: RP
authors.lastname: Swendris
authors.forename: K A
authors.initials: KA
authors.lastname: Parrow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D012086:Reoperation; D014130:Trabeculectomy; D016896:Treatment Outcome
chemical_list: D005472:Fluorouracil