title: Effect of desmopressin (DDAVP) on protein C and protein C inhibitors in uremia.
abstract: The effect of desmopressin (DDAVP) on protein C (PC) and PC inhibitors was investigated in 7 uremic predialysis patients, 7 hemodialysis patients and 7 controls. Significant decrease in PC activity was observed in all groups after DDAVP administration. Desmopressin did not influence PC antigen and two well-known PC inhibitors, plasminogen activator inhibitor-3 and alpha 1-antitrypsin. Thus, it is suggested that DDAVP-induced decrease in PC activity is not related to the changes in PC inhibitors; further studies are needed to clarify the precise mechanisms of the effect of DDAVP on PC in uremia.
authors.affiliation: Hacettepe University School of Medicine, Department of Nephrology, Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Akpolat
authors.forename: O
authors.initials: O
authors.lastname: Ozdemir
authors.forename: N
authors.initials: N
authors.lastname: Arik
authors.forename: F
authors.initials: F
authors.lastname: Demirkan
authors.forename: C
authors.initials: C
authors.lastname: Sungur
authors.forename: O
authors.initials: O
authors.lastname: Ozcebe
authors.forename: S
authors.initials: S
authors.lastname: Dündar
authors.forename: U
authors.initials: U
authors.lastname: Yasavul
authors.forename: C
authors.initials: C
authors.lastname: Turgan
authors.forename: S
authors.initials: S
authors.lastname: Kirazli
mesh_terms: D000328:Adult; D000941:Antigens / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood; D011486:Protein C / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism*; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D000941:Antigens; D015849:Plasminogen Inactivators; D011486:Protein C; D000515:alpha 1-Antitrypsin; D003894:Deamino Arginine Vasopressin