title: Prophylactic application of Propionibacterium avidum KP-40 in swine with acute experimental infections. II. Bacterial infections: pleuropneumonia and swine erysipelas.
abstract: The potent immunomodifier Propionibacterium avidum KP-40 (PA) demonstrated prophylactic potency in swine infected experimentally with Haemophilus (Actinobacillus) pleuropneumoniae or Erysipelothrix rhusiopathiae. Animals received PA either together with the respective vaccine or PA only; 3 resp. 4 weeks later all animals were inoculated with virulent pathogens. Eight of 10 swine immunized with inactivated pleuropneumonia vaccine developed mild-moderate forms of infection with temporary stagnation of body weight; application of the vaccine together with PA lowered the morbidity rate to 1 of 10 (p < 0.05). Also in non-vaccinated swine infected with pleuropneumonia or erysipelas PA application resulted in milder clinical symptoms, faster recovery and a larger gain of body weight.
authors.affiliation: Department of Swine Diseases, National Institute of Veterinary Research, Pulawy, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Markowska-Daniel
authors.forename: Z
authors.initials: Z
authors.lastname: Pejsak
authors.forename: S
authors.initials: S
authors.lastname: Szmigielski
authors.forename: J
authors.initials: J
authors.lastname: Jeljaszewicz
authors.forename: G
authors.initials: G
authors.lastname: Pulverer
mesh_terms: D000189:Actinobacillus Infections / Q000517:prevention & control / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae; D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines; D011001:Pleuropneumonia / Q000517:prevention & control / Q000662:veterinary; D011424:Propionibacterium / Q000276:immunology*; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D013554:Swine Erysipelas / Q000517:prevention & control*
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines