title: In situ remineralization of subsurface enamel lesion after the use of a fluoride chewing gum.
abstract: In situ remineralization of early enamel lesions by a fluoride chewing gum was studied. Human enamel specimens with subsurface lesions were mounted in removable lower appliances for 6 adults. Subjects used a F-free dentifrice 3x/day and chewed five sticks/day for the F gum group (0.1 mg F/stick) or five sticks of sugarless gum. No gum was chewed for controls. Surface microhardness was performed on: (1) sound enamel; (2) lesions; (3) after intraoral exposure, and (4) after acid-resistance testing (ART). Separate specimens were etched and measured for F uptake and image analyses on microradiographs were performed for all regimens. delta Z values were calculated and converted to percent of mineralization. Values for F gum were significantly higher (p > 0.05) than non-F gum and controls for ART, percent remineralization, and F uptake up to 70 microns depth.
authors.affiliation: School of Dentistry, University of Michigan, Ann Arbor 48109-1078.
authors.forename: W J
authors.initials: WJ
authors.lastname: Lamb
authors.forename: R E
authors.initials: RE
authors.lastname: Corpron
authors.forename: F G
authors.initials: FG
authors.lastname: More
authors.forename: E D
authors.initials: ED
authors.lastname: Beltran
authors.forename: D S
authors.initials: DS
authors.lastname: Strachan
authors.forename: C J
authors.initials: CJ
authors.lastname: Kowalski
mesh_terms: D000328:Adult; D002118:Calcium / Q000032:analysis; D002638:Chewing Gum / Q000145:classification; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D003747:Dental Enamel Solubility / Q000187:drug effects; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D006244:Hardness; D006801:Humans; D008297:Male; D008852:Microradiography; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D017001:Tooth Demineralization / Q000473:pathology / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002638:Chewing Gum; D005459:Fluorides; D002118:Calcium