title: Immunogenicity of an acellular pertussis vaccine composed of genetically inactivated pertussis toxin combined with filamentous hemagglutinin and pertactin in infants and children.
abstract: We studied the immunogenicity of an acellular pertussis vaccine composed of genetically detoxified pertussis toxin (PT-9K/129G), filamentous haemagglutinin, and a 69-kilodalton protein, pertactin, in 30 children aged 12 to 24 months and in 80 infants aged 2 to 4 months. A significant increase of the neutralizing titer and of the titers against pertussis toxin, filamentous hemagglutinin, and pertactin, as determined by enzyme-linked immunosorbent assay, was achieved after three doses of vaccine in all the children; a significant increase of these antibody titers was obtained in 100%, 96.1%, 93.5%, and 98.7% of the infants, respectively.
authors.affiliation: Biocine-Sclavo R&D Vaccines, Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Podda
authors.forename: E
authors.initials: E
authors.lastname: Carapella De Luca
authors.forename: L
authors.initials: L
authors.lastname: Titone
authors.forename: A M
authors.initials: AM
authors.lastname: Casadei
authors.forename: A
authors.initials: A
authors.lastname: Cascio
authors.forename: M
authors.initials: M
authors.lastname: Bartalini
authors.forename: G
authors.initials: G
authors.lastname: Volpini
authors.forename: S
authors.initials: S
authors.lastname: Peppoloni
authors.forename: I
authors.initials: I
authors.lastname: Marsili
authors.forename: L
authors.initials: L
authors.lastname: Nencioni
mesh_terms: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D002675:Child, Preschool; D004341:Drug Evaluation; D006388:Hemagglutinins / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D009500:Neutralization Tests; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D010566:Virulence Factors, Bordetella / Q000276:immunology*
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D006388:Hemagglutinins; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D015164:Vaccines, Inactivated; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis; C068929:pertactin; D037342:Pertussis Toxin