Preferential induction of c-fos versus c-jun protooncogene during the immediate early response of pig skin to gamma-rays.
The involvement of the nuclear protooncogenes c-fos and c-jun in the immediate early response of pig dermis cells was studied after in vivo gamma-irradiation. Following high radiation doses (8 to 48 Gy), the two protooncogenes were concomitantly induced, although c-fos induction was preferential. Both inductions were time and dose dependent. Therefore, the early response of the skin to high doses of radiation might involve heterodimeric activator protein 1 composed of c-Fos and c-Jun proteins. Following low radiation doses (0.5 to 2 Gy), c-jun was not induced. By contrast, dramatic c-fos induction was observed after 0.5 Gy, suggesting a specific role for c-fos at low doses.
Martin
M
M
Laboratoire de Radiobiologie Appliquée, DSV, DPTE, Gif sur Yvette, France.
Pinton
P
P
Crechet
F
F
Lefaix
J L
JL
Daburon
F
F
D000818:Animals; D015152:Blotting, Northern; D004307:Dose-Response Relationship, Radiation; D015870:Gene Expression / Q000528:radiation effects*; D016762:Genes, fos / Q000528:radiation effects*; D016758:Genes, jun / Q000528:radiation effects*; D012333:RNA, Messenger / Q000302:isolation & purification*; D011829:Radiation Dosage; D012867:Skin / Q000528:radiation effects*; D013552:Swine
D012333:RNA, Messenger