Improved cortical histology after cementation with a new MMA-DMA-IBMA bone cement: an animal study.
The histological response of bone to inert bone wax, conventional polymethylmethacrylate (PMMA), and a new formulation of bone cement, methylmethacrylate/n-decylmethacrylate/isobornylmethacrylate (MMA/DMA/IBMA) was investigated in canine tibial diaphysis. The new formulation of cement is characterized by a reduced exothermic temperature at curing and reduced leakage of chemicals to the adjacent bone. In comparison with bone wax, the MMA/DMA/IBMA bone cement did not differ significantly with respect to periosteal apposition and bone remodeling, although a tendency to inhibit the biological response was encountered. The MMA/DMA/IBMA was clearly superior to PMMA bone cement in respect to both bone necrosis and repair, as well as bone remodeling.
Nimb
L
L
Department of Orthopedics, Rigshospitalet, University of Copenhagen, Denmark.
Stürup
J
J
Jensen
J S
JS
D000818:Animals; D001843:Bone Cements / Q000737:chemistry; D016723:Bone Remodeling; D001842:Bone and Bones / Q000033:anatomy & histology*; D004285:Dogs; D004338:Drug Combinations; D008689:Methacrylates / Q000737:chemistry; D008768:Methylmethacrylates / Q000737:chemistry; D010168:Palmitates / Q000737:chemistry; D013696:Temperature; D013977:Tibia / Q000033:anatomy & histology; D014885:Waxes / Q000737:chemistry
D001843:Bone Cements; D004338:Drug Combinations; D008689:Methacrylates; D008768:Methylmethacrylates; D010168:Palmitates; D014885:Waxes; C073735:methylmethacrylate-n-decylmethacrylate-isobornylmethacrylate; C055480:bone wax