title: Cervico-thoracic epidural anaesthesia blunts pancuronium-induced increase in heart rate in humans.
abstract: This study was conducted to evaluate the effects of cervico-thoracic epidural anaesthesia upon pancuronium-induced tachycardia in surgical patients. In the control (no blockade) group (n = 8) and the lumbar epidural group (n = 8), pancuronium produced significant increases in heart rate (P < 0.01 and P < 0.01, respectively) and no significant changes in mean arterial pressure. In the cervico-thoracic epidural group (n = 8), no increase in heart rate and a significant decrease in mean arterial pressure were seen following pancuronium. The lack of an increase in heart rate following pancuronium with cervico-thoracic epidural anaesthesia might be due to cardiac sympathetic denervation. The authors concluded that tachycardia after pancuronium administration was attenuated by cervico-thoracic epidural anaesthesia in humans and that the pancuronium-induced tachycardia seemed to be a cardiac sympathomimetic effect.
authors.affiliation: Department of Anesthesiology, Sapporo Medical College and Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Omote
authors.forename: H
authors.initials: H
authors.lastname: Iwasaki
authors.forename: A
authors.initials: A
authors.lastname: Namiki
mesh_terms: D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D002574:Cervical Vertebrae; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine; D008159:Lumbar Vertebrae; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D010197:Pancuronium / Q000494:pharmacology*; D013904:Thoracic Vertebrae; D013997:Time Factors
chemical_list: D008012:Lidocaine; D010197:Pancuronium; D008874:Midazolam