The effect of orengedokuto on experimentally-inflamed rats.
The inhibitory effect of Orengedokuto on lipid peroxide and sialidase was investigated using rats affected with carrageenin cotton pellet-induced granuloma and adjuvant arthritis. As a result, in the case of rats with carrageenin cotton pellet-induced granuloma, a significant inhibitory effect on granuloma formation was observed in the Orengedokuto treated rats (150 mg/kg/day) which showed a decrease in serum lipid peroxide (p < 0.001) and an increase in acid soluble glycoprotein (p < 0.001). In the case of adjuvant-induced arthritic rats, however, the condition of the arthritis was not improved at all, and was even aggravated in spite of the decrease in serum lipid peroxide.
Mizukawa
H
H
Kanagawa Rehabilitation Institute, Japan.
Yoshida
K
K
Honmura
A
A
Uchiyama
Y
Y
Kaku
H
H
Nakajima
S
S
Haruki
E
E
D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002351:Carrageenan; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006023:Glycoproteins / Q000097:blood; D006099:Granuloma / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D019158:N-Acetylneuraminic Acid; D051381:Rats; D017208:Rats, Wistar; D012794:Sialic Acids / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D006023:Glycoproteins; D008054:Lipid Peroxides; D012794:Sialic Acids; C061676:oren gedoku to; D014810:Vitamin E; D002351:Carrageenan; D019158:N-Acetylneuraminic Acid