title: Extensive MHC variability in cichlid fishes of Lake Malawi.
abstract: Lake Malawi in East Africa harbours 500-1,000 endemic species of cichlid fishes, all presumably derived by adaptive radiation from a single founding population within the past two million years. The species of this 'flock' differ strikingly in their ecology and behaviour, moderately in their external morphology and very little in their molecular characteristics. Here we describe high sequence variability of class II major histocompatibility complex genes in a sample of species from Lake Malawi. The variability provides a set of molecular markers for studying adaptive radiation and should be useful for estimating the size of the population that founded the species flock.
authors.affiliation: Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101.
authors.forename: D
authors.initials: D
authors.lastname: Klein
authors.forename: H
authors.initials: H
authors.lastname: Ono
authors.forename: C
authors.initials: C
authors.lastname: O'hUigin
authors.forename: V
authors.initials: V
authors.lastname: Vincek
authors.forename: T
authors.initials: T
authors.lastname: Goldschmidt
authors.forename: J
authors.initials: J
authors.lastname: Klein
mesh_terms: D000353:Africa, Southern; D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D005091:Exons; D005802:Genes, MHC Class II; D007438:Introns; D008969:Molecular Sequence Data; D010471:Perches / Q000235:genetics*; D011110:Polymorphism, Genetic; D017386:Sequence Homology, Amino Acid