Linkage detection by the Affected-Pedigree-Member method: what is really tested?
We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
Babron
M C
MC
INSERM, Unité 155, Paris, France.
Martinez
M
M
Bonaïti-Pellié
C
C
Clerget-Darpoux
F
F
D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D002869:Chromosome Aberrations / Q000453:epidemiology / Q000235:genetics; D025063:Chromosome Disorders; D002888:Chromosomes, Human, Pair 19; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D009657:North Carolina / Q000453:epidemiology; D010375:Pedigree; D013223:Statistics as Topic / Q000379:methods
D005819:Genetic Markers