title: Pelvic exenteration: a treatment for failed rectal cancer surgery.
abstract: Local-regional recurrences of the pelvis occur as an isolated event in 4 to 24 per cent of rectal cancer patients. While radiation therapy may provide temporary relief of pain due to recurrence, only a salvage pelvic exenteration offers hope of cure in these patients. We identified and reviewed 16 rectal cancer cases with local-regional recurrence who underwent salvage pelvic exenteration for cure. There were eight men and eight women. The primary cancer was treated by AP resection (3), low anterior resection (6), Hartman's resection (6), or local excision (1). Tumor at primary resection was Stage I for two patients, II for five patients, and nine patients were Stage III. Adjuvant radiation had been given to nine patients. The type of exenteration required for curative resection was anterior (3), posterior (6), total (4), or total-sacral (3). One patient died postoperatively. Survival calculations were from time of salvage exenteration until death or last follow-up. Only six deaths have occurred with a 5-year survival of 49 per cent. Mean survival for the total group was 31 months. Salvage pelvic exenteration should be given high priority in managing local-regional recurrences of the pelvis and provides worthwhile survival.
authors.affiliation: Dept. of Surgery, Kansas University Medical Center, Kansas City 66103.
authors.forename: N C
authors.initials: NC
authors.lastname: Estes
authors.forename: J H
authors.initials: JH
authors.lastname: Thomas
authors.forename: W R
authors.initials: WR
authors.lastname: Jewell
authors.forename: D
authors.initials: D
authors.lastname: Beggs
authors.forename: C A
authors.initials: CA
authors.lastname: Hardin
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010385:Pelvic Exenteration; D011183:Postoperative Complications / Q000401:mortality; D012004:Rectal Neoplasms / Q000601:surgery*; D012086:Reoperation; D016879:Salvage Therapy; D015996:Survival Rate; D017211:Treatment Failure