A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.
The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.
Kok
K
K
Department of Medical Genetics, University of Groningen, The Netherlands.
Hofstra
R
R
Pilz
A
A
van den Berg
A
A
Terpstra
P
P
Buys
C H
CH
Carritt
B
B
D000595:Amino Acid Sequence; D001483:Base Sequence; D002893:Chromosomes, Human, Pair 3; D004247:DNA / Q000737:chemistry; D016147:Genes, Tumor Suppressor; D006801:Humans; D008025:Ligases / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D044764:Ubiquitin-Activating Enzymes; D044767:Ubiquitin-Protein Ligases
D004247:DNA; D044767:Ubiquitin-Protein Ligases; D008025:Ligases; D044764:Ubiquitin-Activating Enzymes