title: Gastrin and gastrin-related responses to infection with Ostertagia ostertagi in the calf.
abstract: The effects of a single challenge with 60,000 infective Ostertagia ostertagi larvae on blood and gastrointestinal mucosal gastrin concentrations, gastrin-producing G-cell numbers in the pyloric mucosa and growth of different parts of the gut were investigated in 16, two-and-a-half-month-old calves. Infected calves exhibited a rise in abomasal pH which was accompanied by a 145 per cent increase in wet weight of the fundic mucosa (P < 0.05) and a significant rise in blood total gastrin concentrations (P < 0.01). Circulating little gastrin (G-17) was unaffected. Pyloric mucosal total gastrin concentrations remained unaltered in the infected calves until day 28 when levels fell to 36.9 per cent of control group values (P < 0.01). Pyloric mucosal G-cell numbers declined during the experiment in the infected group. It is suggested that release of previously stored tissue gastrin and not a change in G-cell numbers contributes to the hypergastrinaemia associated with ostertagia infection in the calf.
authors.affiliation: Department of Veterinary Pathology, Royal Veterinary College, London.
authors.forename: M T
authors.initials: MT
authors.lastname: Fox
authors.forename: A P
authors.initials: AP
authors.lastname: Carroll
authors.forename: S A
authors.initials: SA
authors.lastname: Hughes
authors.forename: U E
authors.initials: UE
authors.lastname: Uche
authors.forename: D E
authors.initials: DE
authors.lastname: Jacobs
authors.forename: C
authors.initials: C
authors.lastname: Vaillant
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D005753:Gastric Mucosa / Q000473:pathology*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D010028:Ostertagia / Q000302:isolation & purification; D010029:Ostertagiasis / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D010270:Parasite Egg Count; D010435:Pepsinogens / Q000097:blood; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: D005755:Gastrins; D010435:Pepsinogens