Plasma lipids and VLDL composition in male non-insulin dependent diabetic patients: relation with HbA1c levels.
In this study, plasma lipids and VLDL composition were measured in 22 middle aged male patients with non-insulin dependent diabetes and compared with 15 non-diabetic controls. Data for the diabetics were differentiated on the basis of hemoglobin A1c levels of less than or greater than 7%. Compositional abnormalities of VLDL were more frequent in the diabetic patients with HbA1c of > 7%. VLDL-cholesterol, triglycerides and phospholipids were elevated in all diabetics whereas VLDL-Apo B was increased only in diabetics with HbA1c > 7%. Apo CII and Apo CIII levels and also apo CII/apo CIII ratio were also reduced with HbA1c levels of more than 7%. Increases in the apo E and apo E/apo C ratio were also seen in the more hyperglycemic diabetics with HbA1c levels of > 7%. In contrast apo CII and apo CIII levels and also apo CII/apo CIII ratio remained unaltered in diabetic patients with less than 7% HbA1c levels. In these patients increases in the apo E levels were found while the apo E/apo C ratio remained unaltered.
Cuesta
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C
Instituto de Nutrición y Bromatología, (Centro Mixto UCM-CSIC), Universidad Complutens, Madrid, Spain.
Ródenas
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S
Sánchez-Cabezudo
M
M
D000284:Administration, Oral; D001053:Apolipoproteins / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005905:Glyburide / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D001053:Apolipoproteins; D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D014280:Triglycerides