Pericentric region of chromosome 9 is a possible candidate region for linkage study of schizophrenia.
We have undertaken a systematic G-banding survey to find structural chromosomal abnormalities among patients with schizophrenia. Of 120 patients with DSM-III-R schizophrenia, four (3.3%) had a pericentric inversion of chromosome 9 and three (2.5%) had a X/XX mosaicism. The frequency of pericentric inversion of chromosome 9 among patients with schizophrenia was statistically higher than those among newborns and Asian populations. Our results indicate that the pericentric region of chromosome 9 might be one of the potential regions of interest for linkage analysis of schizophrenia.
Nanko
S
S
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Kunugi
H
H
Sasaki
T
T
Fukuda
R
R
Kawate
T
T
Kazamatsuri
H
H
D000293:Adolescent; D000328:Adult; D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology