title: [Administration of human AT-III in a case of lupus anticoagulant positive pregnancy].
abstract: A 26-year-old pregnant woman was diagnosed as having both lupus anticoagulant (LA) and anticardiolipin antibody (ACA). Her previous pregnancy ended in intrauterine fetal death at 27 weeks' gestation. During the present pregnancy she was treated with aspirin, dipiridamole, predonisolone, and heparin. At 24 weeks, fetal growth became retarded, accompanied by markedly decreased activities of AT-III, protein C, plasminogen and alpha 2-plasmin inhibitor. Supplement of human AT-III led both to prolongation of the gestational period and improvement of fetal growth. The pregnancy ended in cesarean section because of signs of fetal distress at 30 weeks. The infant was a 1025-g male with Apgar scores of 5 and 9 at one and five minutes, respectively, and is healthy. The mother developed DIC after surgery, but recovered after therapy. In this case, TAT, alpha 2PI-plasmin complex, FDP Ddimer, FPB beta 15-42, L-FDP showed little correlation with the clinical course.
authors.affiliation: Department of Gynecology and Obstetrics, Suita Municipal Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Hirooka
authors.forename: M
authors.initials: M
authors.lastname: Hayashida
authors.forename: T
authors.initials: T
authors.lastname: Nasu
authors.forename: T
authors.initials: T
authors.lastname: Tsubakio
authors.forename: Y
authors.initials: Y
authors.lastname: Doi
authors.forename: W
authors.initials: W
authors.lastname: Yoshihara
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Hosono
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D000990:Antithrombin III / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016682:Lupus Coagulation Inhibitor / Q000032:analysis*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; D000990:Antithrombin III