Conioidines A and B, novel DNA-interacting pyrrolidines from Chamaesaracha conioides.
Two novel pyrrolidine compounds, conioidines A [1] and B [2], have been isolated from the Texas plant, Chamaesaracha conioides (Solanaceae). Their structures were determined by spectroscopic methods and hydrolysis studies. Both natural products, like doxorubicin, showed DNA-specific KB cell cytotoxicity. Dose-response data indicated a Kd value of 2.8 microM for binding of conioidine A [1] to calf thymus DNA.
Chan
G W
GW
SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
Berry
D
D
DeBrosse
C W
CW
Hemling
M E
ME
MacKenzie-LoCasto
L
L
Offen
P H
PH
Westley
J W
JW
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects*; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D007624:KB Cells; D010946:Plants, Medicinal / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*; D012991:Solanaceous Alkaloids / Q000737:chemistry / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D011759:Pyrrolidines; D012991:Solanaceous Alkaloids; C082005:conioidine A; C082006:conioidine B; D004317:Doxorubicin