title: Chromosomal anomalies in 1,000 children referred with suspected genetic disorders.
abstract: One thousand children ranging from newborns to 13 years of age with a variety of clinical disorders were referred to us to investigate the possible presence of chromosomal abnormalities. Various types of chromosomal anomalies were found in 166 children (16.6%), which is significantly (p < 0.01) higher than in an unselected (control) population (0.48-0.55%). The male:female ratio was 3:2 for the total population. Furthermore, in our survey population, the sex ratio of Down's syndrome cases of males to females was 3:2.
authors.affiliation: Division of Genetics, Long Island College Hospital-SUNY Health Science Center, Brooklyn 11201.
authors.forename: D
authors.initials: D
authors.lastname: Navsaria
authors.forename: T
authors.initials: T
authors.lastname: Mathews
authors.forename: R A
authors.initials: RA
authors.lastname: Conte
authors.forename: R S
authors.initials: RS
authors.lastname: Verma
mesh_terms: D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000453:epidemiology*; D025063:Chromosome Disorders; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D005600:Fragile X Syndrome / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D014424:Turner Syndrome / Q000453:epidemiology