[Synthesis of lipoxygenase inhibitors. 1. Synthesis of open-ring amidrazones].
The synthesis of some amidrazones as bioisosteric diazaallyl radicals is described starting from the reaction mechanism of the lipoxygenases which postulates the existence of a radical after hydrogen abstraction from the arachidonic acid, N1,N3-diaryl-, N1-aryl-N3-alkyl-benzamidrazones and N1-arylacetamidrazones are strong inhibitors of the soja lipoxygenase.
Nuhn
P
P
Institut für Pharmazeutische Chemie, Fachbereich Pharmazie, Martin-Luther-Universität Halle-Wittenberg.
Büge
A
A
Harenberg
P
P
Lettau
H
H
Moschner
K
K
Rauchmaul
M
M
Schneider
R
R
D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008715:Methionine / Q000378:metabolism; D010084:Oxidation-Reduction; D013025:Glycine max / Q000201:enzymology
D006835:Hydrazones; D016859:Lipoxygenase Inhibitors; D008715:Methionine
Synthese von Lipoxygenaseinhibitoren. 1. Mitteilung: Synthese von offenkettigen Amidrazonen.