Alpha 2-antiplasmin deficiency. An overlooked cause of hemorrhage.
OBJECTIVE
Alpha 2-Antiplasmin (AP) deficiency is a rare congenital bleeding disorder that presents with normal screening tests for platelet function and clotting. We believe that this disorder is frequently overlooked, especially in women with unexplained bleeding.


METHODS
We report on two families and one single patient with heterozygous AP deficiency.


RESULTS
All patients and most relatives with the defect had a mild bleeding tendency.


CONCLUSIONS
We suggest the incorporation of the AP assay in all patients who have a bleeding disorder with normal platelet studies and normal clotting profiles.
Griffin
G C
GC
Department of Pediatrics, University of California Davis, Sacramento.
Mammen
E F
EF
Sokol
R J
RJ
Perrotta
A L
AL
Stoyanovich
A
A
Abildgaard
C F
CF
D000328:Adult; D002648:Child; D005260:Female; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D008595:Menorrhagia / Q000209:etiology; D000979:alpha-2-Antiplasmin / Q000737:chemistry / Q000172:deficiency*
D000979:alpha-2-Antiplasmin