[The effect of the amino sugar glucosamine on the endogenous intoxication processes in pulmonary edema in rats].
The effects of glycosamine aminosugar on the processes of endotoxicosis and lipid peroxidation were thoroughly studied in rats with toxic pulmonary edema. There was a glycosamine-induced decrease in markers of endotoxicosis, such as medium-weight molecular peptides and malonic dialdehyde in serum and lung tissue. Administration of exogenous glucosamine resulted in its incorporation into the membranes of target organs, connective tissue and normalized the levels of endogenous N-acetyl-glucosamine, which finally determined antitoxic and antioxidative properties in this aminosugar.
Pliushch
S I
SI
Zupanets
I A
IA
Drogovoz
S M
SM
Isaev
S G
SG
D000643:Ammonium Chloride; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005944:Glucosamine / Q000378:metabolism / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D046911:Macromolecular Substances; D008315:Malondialdehyde / Q000378:metabolism; D008970:Molecular Weight; D010455:Peptides / Q000187:drug effects / Q000378:metabolism; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats
D046911:Macromolecular Substances; D010455:Peptides; D000643:Ammonium Chloride; D008315:Malondialdehyde; D005944:Glucosamine
Vliianie aminosakhara gliukozamina na sostoianie protsessov éndotoksikoza pri oteke legkikh u krys.