Choledocho-ureteral anastomosis in the rat. A new experimental model of long-term, total, internal bile diversion.
Choledocho-ureteral anastomosis is a new experimental model of total bile diversion in the rat. The anastomosis is carried out using a polyethylene tutor drain and requires neither an external drain nor restraint of the animal. After 14 days of diversion, bile flow fell by 53% and there were no biological signs of cholestasis. The rats survived for up to 2 months. Choledocho-ureteral anastomosis is a reliable and simple experimental model which can be used to study the effects of prolonged interruption of enterohepatic bile-acid circulation.
Audry
G
G
Equipe de Physiologie et Pharmacologie Hépatique, INSERM U-181, CHU Saint-Antoine, Paris, France.
Giral
P
P
Bonnefis
M T
MT
Legendre
C
C
Myara
A
A
Poupon
R
R
D000714:Anastomosis, Surgical; D000818:Animals; D001652:Bile Ducts / Q000601:surgery*; D004764:Enterohepatic Circulation; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014513:Ureter / Q000601:surgery*