Procolipase mRNA: tissue localization and effects of diet and adrenalectomy.
Northern blot analysis has identified procolipase mRNA in rat pancreas, stomach and duodenum. Pancreatic colipase mRNA was increased by high-fat diets. Adrenalectomy increased pancreatic procolipase mRNA, an effect enhanced by high-fat diets. The results suggest that colipase is not unique to the pancreas and that diet and glucocorticoids interact in regulating the transcription of its gene.
Okada
S
S
Louisiana State University, Pennington Biomedical Research Center, Baton Rouge 70808-4124.
York
D A
DA
Bray
G A
GA
D000199:Actins / Q000235:genetics; D000315:Adrenalectomy; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003089:Colipases / Q000096:biosynthesis* / Q000235:genetics; D003345:Corticosterone / Q000097:blood; D015342:DNA Probes; D004032:Diet; D004792:Enzyme Precursors; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D009928:Organ Specificity; D011498:Protein Precursors / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley
D000199:Actins; D003089:Colipases; D015342:DNA Probes; D004792:Enzyme Precursors; D015345:Oligonucleotide Probes; D011498:Protein Precursors; D012333:RNA, Messenger; C037107:procolipase; D003345:Corticosterone