Effect of chronic capsaicin and guanethidine treatment on skin blood flow of the rat.
Using a non-invasive laser Doppler velocimetry technique to measure skin blood flow in the rat skin, we have shown that chronic treatment with capsaicin inhibited the vasodilator response to a non-pathological, local heat (44 degrees C, 20 min duration) stimulus. However, sympathectomy, accomplished with chronic treatment of guanethidine, had no effect on this heat-induced vasodilation. Topical steroids have also been shown to inhibit this response thus, since the heat-dilator response appears from these results to be brought about by the release of sensory neuropeptides, the sensory neuron may be a target for topical steroid action.
Ahluwalia
A
A
Department of Biochemical Pharmacology, William Harvey Research Institute, St. Bartholomew's Medical College, London, UK.
Flower
R J
RJ
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D006145:Guanethidine / Q000494:pharmacology*; D006358:Hot Temperature; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D002211:Capsaicin; D006145:Guanethidine