Individual theophylline dosing based on bioelectrical impedance analysis.
The role of bioelectrical impedance (BI) analysis in determining slow-release theophylline dosage was evaluated in fifteen healthy subjects given a standard 200 mg dose. Reactance and l/resistance were identified as the most significant predictors of pre-dose, steady-state theophylline concentrations (Css,pre). Compared with doses based on body weight (8.8 mg kg-1 day-1), theophylline doses determined by BI analysis (9.6 +/- 2.4 mg kg-1 day-1) resulted in less biased (mean prediction error = 0.6 vs 1.4) though slightly less precise (mean squared error = 7.1 vs 6.3) Css,pre values. These differences were statistically insignificant (P > 0.05).
Sidhu
J S
JS
Department of Pharmacy, University of Queensland, Australia.
Triggs
E J
EJ
Charles
B G
BG
Smithurst
B A
BA
D000293:Adolescent; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D003692:Delayed-Action Preparations; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D013806:Theophylline / Q000008:administration & dosage* / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D013806:Theophylline