[The effect of ouabain on the cardiovascular system of rats with chronic heart failure].
The response of the rat cardiovascular system to the cardiac glycoside ouabain was studied in an original model of heart failure developed on day 21 of coronary embolization with 15 microns radioactive microspheres introduced into the left ventricular cavity during ascending aortic occlusion. To examine systemic and regional hemodynamic parameters, the tracer technique with microspheres. Ouabain infused to rats with heart failure caused an increase in the index of left ventricular contractility, cardiac output, stroke volume, myocardial contractility, blood flow in most viscera and a decrease in end-diastolic pressure. The findings suggest that 21 days after coronary embolization the rats with heart failure proved more sensitive to the glycoside than did those sham-operated and thus, the presented model adequately reflects the status of the cardiovascular system when heart failure is evolving.
Gorodetskaia
E A
EA
Allabergenova
E A
EA
Medvedev
O S
OS
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D003328:Coronary Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D008863:Microspheres; D010042:Ouabain / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D010042:Ouabain
Vliianie uabaina na serdechno-sosudistuiu sistemu krys s khronicheskoĭ serdechnoĭ nedostatochnost'iu.