title: Acral lentiginous melanoma.
abstract: Between 1958 and 1990, 82 patients with acral lentiginous melanoma were treated by the Tulane Surgical Service with regional perfusion, excision of lesion, and lymph node dissection. The patient group comprised 27 white men, 29 white women, 18 black men, and 8 black women, with an average age of 61 years. More foot lesions than hand lesions were reported, and all the lack men had foot lesions. In stage I patients, overall 5-year survival rates were 65% at 5 years and 44% at 10 years, with differences by race and gender. The black men did poorest, with a 13% 10-year survival rate. Survival rates were worse with increasing disease stage when calculated using univariate analysis. The 5-year survival rate of all patients with stage III and stage IV disease was 26%. A multivariate analysis was performed in 78 of 82 patients in whom all variables of Clark's level, age, race, stage, and sex were known. A strong relationship was observed between decreasing survival time and increasing Clark's level, with stage of marginal significance. In a multivariate analysis of patients with stage I disease, an increasing level of invasion was found to be significant, with a trend for a relationship to thickness. A trend toward decreased survival time was observed in men and blacks.
authors.affiliation: Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112.
authors.forename: C M
authors.initials: CM
authors.lastname: Sutherland
authors.forename: F J
authors.initials: FJ
authors.lastname: Mather
authors.forename: J H
authors.initials: JH
authors.lastname: Muchmore
authors.forename: R D
authors.initials: RD
authors.lastname: Carter
authors.forename: R J
authors.initials: RJ
authors.lastname: Reed
authors.forename: E T
authors.initials: ET
authors.lastname: Krementz
mesh_terms: D000367:Age Factors; D044383:Black People; D005260:Female; D005528:Foot / Q000473:pathology*; D006225:Hand / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000556:secondary; D008875:Middle Aged; D009367:Neoplasm Staging; D012737:Sex Factors; D012878:Skin Neoplasms / Q000473:pathology*; D015996:Survival Rate; D044465:White People