title: Buspirone therapy for Type A behavior, hostility, and perceived stress in cardiac patients.
abstract: Hostility is considered to be a risk factor for coronary artery disease. Despite the findings of reduced serotonergic function and effectiveness of treatment with serotonergic agents in similar symptom complexes, there have been no attempts at using serotonergic psychopharmacologic agents to treat this population. We conducted an 8-week open trial of 10 type A, irritable men with coronary artery disease and no diagnosable psychiatric (axis I) condition to examine the effects of buspirone on these subjects. Buspirone appears to significantly reduce type A behavior, hostility, anxiety, impatience, and perceived stress.
authors.affiliation: Department of Psychiatry and Preventive Medicine, Massachusetts General Hospital, Boston 02114.
authors.forename: A B
authors.initials: AB
authors.lastname: Littman
authors.forename: M
authors.initials: M
authors.lastname: Fava
authors.forename: K
authors.initials: K
authors.lastname: McKool
authors.forename: S
authors.initials: S
authors.lastname: Lamon-Fava
authors.forename: E
authors.initials: E
authors.lastname: Pegg
mesh_terms: D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects*; D002065:Buspirone / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy* / Q000523:psychology; D006791:Hostility; D006801:Humans; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment; D014434:Type A Personality
chemical_list: D002065:Buspirone