title: Relationship between viral antibodies and bronchial hyperresponsiveness in 495 unselected children and adolescents.
abstract: The purpose of this study was to investigate whether recent and previous subclinical viral respiratory infection can explain the presence of increased bronchial responsiveness to histamine. We studied a randomly selected population of 495 children and adolescents, aged 7-16 years, from Copenhagen. If the subjects had had symptoms of respiratory infection recently, the examination was postponed for at least 6 weeks. Bronchial hyperresponsiveness (BHR) to inhaled histamine was found in 79 (16%) of the subjects, of whom 28 had asthma. Forty-eight subjects (10%) had increased levels of serum IgM antibodies against either parainfluenza, influenza, adenovirus, or respiratory syncytial virus (RSV), reflecting a recently acquired infection. No association between BHR and antibodies against respiratory viruses was found, as 7 (8.9%) of the 79 subjects with BHR and 41 (9.9%) of the 416 subjects without BHR had viral antibodies. Furthermore, no association between degree of bronchial responsiveness and viral antibodies was found. Moreover, 251 individuals (51%) had signs of earlier RSV infection, i.e. IgG antibodies against RSV. No relationship was found between age of the subjects and the presence of antibodies against either respiratory viruses in general or IgG-RSV. No relationship was found between the presence of antibodies against RSV and BHR; furthermore, evidence of earlier RSV infection was unrelated to the level of lung function and degree of bronchial responsiveness. We conclude that increased bronchial responsiveness in asymptomatic, unselected schoolchildren and adolescents is not likely to be caused by recent or previous viral respiratory infections.
authors.affiliation: Department of Medicine B, University Hospital, Copenhagen, Denmark.
authors.forename: V
authors.initials: V
authors.lastname: Backer
authors.forename: C S
authors.initials: CS
authors.lastname: Ulrik
authors.forename: N
authors.initials: N
authors.lastname: Bach-Mortensen
authors.forename: G
authors.initials: G
authors.lastname: Glikmann
authors.forename: C H
authors.initials: CH
authors.lastname: Mordhorst
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D001985:Bronchial Provocation Tests; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005541:Forced Expiratory Volume; D006632:Histamine; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D011897:Random Allocation; D012141:Respiratory Tract Infections / Q000097:blood* / Q000150:complications; D012882:Skin Tests; D014777:Virus Diseases / Q000097:blood* / Q000150:complications
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E; D006632:Histamine