[The effect of mexidol on the development of experimental peroxide athero-arteriosclerosis].
A rabbit model of peroxide atherosclerosis was used to examine the new psychotropic drug Mexydol for its angioprotective properties. The agent was found to inhibit atheroarteriosclerotic manifestations such as hyperlipemia, activated lipid peroxidation, lower activity of the antioxidative system and to produce protective effects on the local vascular mechanisms of atherogenesis, by diminishing the severity of aortic lesion.
Deviatkina
T A
TA
Kovalenko
E G
EG
Smirnov
L D
LD
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D010847:Picolines / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011817:Rabbits
D000975:Antioxidants; D008055:Lipids; D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate
Vliianie meksidola na razvitie éksperimental'nogo perekisnogo ateroarterioskleroza.