Foetal loss and infant deaths in families of children with soft-tissue sarcoma.
Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis.
Hartley
A L
AL
CRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.
Birch
J M
JM
Blair
V
V
Kelsey
A M
AM
Morris Jones
P H
PH
D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005190:Family; D005260:Female; D005313:Fetal Death / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D008423:Maternal Age; D017253:Neurofibromatoses / Q000235:genetics; D011247:Pregnancy; D012208:Rhabdomyosarcoma / Q000235:genetics*; D012509:Sarcoma / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*