Functional heterogeneity of the caudate-putamen as revealed by c-fos induction in response to D1 receptor activation.
SKF 38,393, a dopamine receptor agonist which stimulates the D1 receptor, has been shown to activate c-fos to a detectable level in rats only when the striatum has been sensitized by a previous 6-OHDA lesion of the nigrostriatal tract. In the present study, we reexamine the effect of SKF 38,393 by in situ hybridization in non-lesioned mice and show an induction of c-fos mRNA which is restricted to the ventricular edge and to the caudal part of the caudoputamen (CP) even with large doses of SKF 38,393. These results suggest a functional heterogeneity in the CP in response to dopaminergic drugs, which could reflect the anatomical or neurochemical heterogeneity of the striatum itself and its neuroanatomical connections.
Arnauld
E
E
INSERM U. 176, Bordeaux, France.
Arsaut
J
J
Demotes-Mainard
J
J
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D016762:Genes, fos / Q000187:drug effects*; D017403:In Situ Hybridization; D051379:Mice; D011699:Putamen / Q000187:drug effects* / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000187:drug effects*
D017447:Receptors, Dopamine D1; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine