title: Control of inflammatory processes by adhesion glycoproteins.
abstract: Cell surface adhesive glycoproteins are principal regulators of nearly all aspects of immune/inflammatory responses. Using monoclonal antibodies to individual adhesion molecules, the expression and contribution of specific molecules in the pathogenesis of allergen-induced airway hyperresponsiveness in monkeys has been studied. Results confirm the importance of cell adhesion and demonstrate that antagonism of a single adhesion molecule may provide a novel therapeutic approach.
authors.affiliation: Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
authors.forename: C D
authors.initials: CD
authors.lastname: Wegner
authors.forename: R H
authors.initials: RH
authors.lastname: Gundel
authors.forename: L
authors.initials: L
authors.lastname: Churchill
authors.forename: L G
authors.initials: LG
authors.lastname: Letts
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004727:Endothelium / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007962:Leukocytes / Q000502:physiology; D011485:Protein Binding
chemical_list: D015815:Cell Adhesion Molecules