title: Smooth pursuit eye movement deficits after pontine nuclei lesions in humans.
abstract: Eye movements were recorded electroculographically in four patients with basal pontine lesions, demonstrated by MRI. The most prominent eye movement abnormality observed was mild to severe impairment of smooth pursuit and optokinetic nystagmus, mainly ipsilateral to the lesion. This abnormality is thought to result from damage to the pontine nuclei, which form a crucial relay between the cerebral cortex and the cerebellum controlling smooth pursuit. Abnormalities of saccades and the vestibulo-ocular reflex in one patient are also discussed.
authors.affiliation: Clinique Neurologique, Hôpital de la Salpêtrière, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Gaymard
authors.forename: C
authors.initials: C
authors.lastname: Pierrot-Deseilligny
authors.forename: S
authors.initials: S
authors.lastname: Rivaud
authors.forename: S
authors.initials: S
authors.lastname: Velut
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology; D004585:Electrooculography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000503:physiopathology; D011149:Pons / Q000473:pathology / Q000503:physiopathology*; D011698:Pursuit, Smooth / Q000502:physiology*