Retinal cone dysfunction of supernormal rod ERG type. Five new cases.
Five patients, not related to each other, showed clinical signs, including electroretinograms, of a retinal dysfunction which mainly affected the cone system, but also involved the rod responses in a peculiar way. ERG b-wave threshold under dark adapted conditions was elevated. In contrast, rod b-wave sensitivity was enhanced with medium to high intensity flash stimulation. Furthermore, all patients had a severe reduction of the oscillatory potentials. The findings are discussed with special emphasis on a hypothetical disturbance in the cyclic guanosine monophosphate metabolism, involving both photoreceptors and cells of the inner plexiform layer responsible for retinal feedback mechanisms.
Rosenberg
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National Eye Clinic for The Visually Impaired, Hellerup, Denmark.
Simonsen
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SE
D000328:Adult; D002648:Child; D003623:Dark Adaptation; D004596:Electroretinography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009991:Oscillometry; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000503:physiopathology*; D012164:Retinal Diseases / Q000503:physiopathology*; D012684:Sensory Thresholds