title: Alveolar soft-part sarcoma: evidence for its myogenic origin and for the involvement of 17q25.
abstract: A typical case of alveolar soft-part sarcoma was examined using ultrastructural, immunohistochemical and cytogenetic methods. Immunohistochemical stains were performed on frozen sections and showed strong desmin expression with the three anti-desmin antibodies used. In addition, the tumour cells were weakly positive for vimentin and myosin. Neural markers were negative. Chromosomal analysis showed consistent involvement of 17q25--an abnormality which has been reported in another alveolar soft-part sarcoma. The histogenesis of alveolar soft-part sarcoma is still debatable but our findings support a myogenic origin. The finding of an apparently identical chromosomal abnormality in two of three thus far examined cases of alveolar soft-part sarcoma is of interest and must await further confirmation, but it may result in the identification of a chromosomal marker for this enigmatic tumour and thus pave the way for further molecular elucidation.
authors.affiliation: Department of Pathology, Catholic University of Leuven, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: R
authors.initials: R
authors.lastname: De Vos
authors.forename: B
authors.initials: B
authors.lastname: Van Damme
authors.forename: I
authors.initials: I
authors.lastname: De Wever
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: V J
authors.initials: VJ
authors.lastname: Desmet
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17; D003893:Desmin / Q000378:metabolism; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology; D009218:Myosins / Q000378:metabolism; D018234:Sarcoma, Alveolar Soft Part / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D003893:Desmin; D005819:Genetic Markers; D014746:Vimentin; D009218:Myosins