Synergistic effect of ethanolic extract of propolis and antibiotics on the growth of staphylococcus aureus.
Ethanolic extract of propolis (EEP), known to possess marked antibacterial activity, was incubated with 8 different common antibiotics in culture medium containing a fixed amount of a standard strain of Staphylococcus aureus. The antibiotic compounds used were: penicillin G, doxycycline, streptomycin, cloxacillin, chloramphenicol, cefradine, ampicillin and polymyxin B. They were used in varying levels, ranging between 0.000005-125.0 micrograms/ml or units, resp. Firstly, their minimal inhibitory concentrations were established in the absence of EEP, than EEP was added in concentrations up to 600 micrograms/ml. EEP had a marked synergistic effect on the antibacterial activity of streptomycin and cloxacillin, and a moderate synergistic effect on the others, except ampicillin.
Krol
W
W
Department of Microbiology and Immunology, Silesian School of Medicine, Zabrze-Rokitnica, Poland.
Scheller
S
S
Shani
J
J
Pietsz
G
G
Czuba
Z
Z
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D000431:Ethanol; D008826:Microbial Sensitivity Tests; D011429:Propolis / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D000431:Ethanol; D011429:Propolis