title: Two-locus and bivariate segregation analysis of HDL-C and apo AI.
abstract: Two-locus and bivariate segregation analyses of HDL-C and apo AI were carried out using the GAW8 Berkeley data set. For HDL-C, results are ambiguous. Both the mixed environmental model and the mixed Mendelian model fit the data equally well. For apo AI, however, univariate one-locus segregation analysis suggests a Mendelian major gene controlling its levels. Moreover, two-locus analysis suggests a second major gene is involved. Bivariate segregation analysis indicates these data cannot resolve the question as to whether a single Mendelian major gene with pleiotropic effects controls levels of both HDL-C and apo AI in humans.
authors.affiliation: Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
authors.forename: J F
authors.initials: JF
authors.lastname: Xu
authors.forename: V L
authors.initials: VL
authors.lastname: Prenger
authors.forename: J
authors.initials: J
authors.lastname: Coresh
authors.forename: T H
authors.initials: TH
authors.lastname: Beaty
mesh_terms: D016632:Apolipoprotein A-I / Q000235:genetics*; D008076:Cholesterol, HDL / Q000235:genetics*; D003198:Computer Simulation; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL