Influence of factors in the digestive tract on the progression of chronic renal failure.
To elucidate the mechanisms by which factors in the digestive tract influence the progressive chronic renal failure in rats, we employed the oral adsorbent, AST-120, which can adsorb certain uremic toxins in the gastrointestinal fluid. Administration of AST-120 firstly delayed the appearance of systemic hypertension, secondly delayed the increase in the amount of urinary protein excretion, and finally delayed the emergence of glomerular hypertrophy and glomerulosclerosis. The data obtained did not provide evidence for an inhibitory effect of AST-120 on hypertension. Our results therefore suggest that a pressor substance or its precursor exists in the digestive tract of rats with chronic renal failure.
Takahashi
S
S
Nishi-Kofu National Hospital, Yamanashi, Japan.
Okada
K
K
Shimamura
T
T
D000327:Adsorption; D000818:Animals; D001794:Blood Pressure; D002244:Carbon / Q000627:therapeutic use*; D004064:Digestive System / Q000378:metabolism*; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D007677:Kidney Function Tests; D008297:Male; D010087:Oxides / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014118:Toxins, Biological / Q000378:metabolism*
D010087:Oxides; D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D002244:Carbon; C040896:AST 120