title: The role of adhesion molecules in reperfusion injury.
abstract: Leukocytes can produce vascular injury following ischemia and reperfusion of tissue resulting in thrombosis, edema and necrosis. Leukocyte adhesion to endothelial cells allows formation of a protected microenvironment where inflammatory molecules can exceed anti-inflammatory molecules thus resulting in injury. Blocking adherence with monoclonal antibodies to adherence molecules can prevent reperfusion injury to a variety of organs. In particular, antibodies to CD18 and P-selectin have been shown to be effective in ameliorating injury.
authors.affiliation: University of Washington, Seattle 98195.
authors.forename: R K
authors.initials: RK
authors.lastname: Winn
authors.forename: N B
authors.initials: NB
authors.lastname: Vedder
authors.forename: D
authors.initials: D
authors.lastname: Mihelcic
authors.forename: L C
authors.initials: LC
authors.lastname: Flaherty
authors.forename: L
authors.initials: L
authors.lastname: Langdale
authors.forename: J M
authors.initials: JM
authors.lastname: Harlan
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology*; D007962:Leukocytes / Q000502:physiology*; D015427:Reperfusion Injury / Q000276:immunology* / Q000517:prevention & control; D012771:Shock, Hemorrhagic / Q000276:immunology
chemical_list: D015815:Cell Adhesion Molecules