Prevention of ethanol-induced gastric damage by the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 in rats.
The protective effects of the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 against ethanol-induced gastric damage were investigated. Gastric lesions were induced in rats by the oral administration of 1 ml of absolute ethanol. Ro 15-4513 (2.5-10 mg/kg, IP) or Ro 15-3505 (5-20 mg/kg, IP), administered 30 min before ethanol, protected against ethanol-induced gastric damage. The protective effects of these compounds were blocked by the benzodiazepine antagonist, flumazenil (10 mg/kg, IP). These results present evidence for the involvement of the GABA-benzodiazepine receptor complex in the pathogenesis of ethanol-induced gastric damage.
Najim
R A
RA
Department of Pharmacology, College of Medicine, University of Baghdad, Iraq.
Karim
K H
KH
D000818:Animals; D001386:Azides / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D001570:Benzodiazepinones / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D000431:Ethanol; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D001386:Azides; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000431:Ethanol; D005442:Flumazenil; C040725:Ro 15-3505; C042957:Ro 15-4513