[Pulsed steroid therapy for active ulcerative colitis patients].
Six severe and 7 moderately severe ulcerative colitis patients were treated by pulsed steroid therapy. For one course of the therapy, either 0.5 or 1 gram of hydrocortisone-21 sodium succinate or methylprednisolone sodium succinate was given once a day intravenously for 3 consecutive days, following 4 days with no infusion. The patients were treated for 3 to 6 courses. Ten patients entered clinical remission, 1 patient improved, and therapy failed for 2 patients. Judged endoscopically, 5 patients achieved remission. Six patients improved and 2 patients did not improve. Severe side effect was not noted as to stop the medication. One patient had hyperglycemia for a few days after the start of the first course, this patient received total parenteral nutrition. Three patients showed moon face. Steroid withdrawal syndrome did not develop.
Oshitani
N
N
Third Department of Internal Medicine, Osaka City University Medical School.
Kitano
A
A
Okabe
H
H
Nakamura
S
S
Matsumoto
T
T
Kobayashi
K
K
D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage*; D008875:Middle Aged
D008776:Methylprednisolone Hemisuccinate; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone