[The pharmacological properties of coenzyme A disulfide].
Coenzyme A disulfide (CoA disulfide) was pharmacologically studied. It has been found to normalize lipid and carbohydrate metabolism when given in a dose of 2 mg/kg, i.m., in diverse liver dysfunctions. It possesses an antihypoxic action under hemic and histotoxic hypoxia. When given in small doses (80-160 micrograms/kg, i.v.), CoA disulfide depresses the function of cellular hemostasis.
Avakumov
V M
VM
Krylov
Iu F
IuF
Karaev
A L
AL
Muliar
A G
AG
Smirnova
T N
TN
Kovler
M A
MA
Filina
E A
EA
D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism; D003065:Coenzyme A / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006487:Hemostasis / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy / Q000378:metabolism; D011488:Protein Deficiency / Q000188:drug therapy / Q000378:metabolism; D051381:Rats
C017145:coenzyme A disulfide; D003065:Coenzyme A
Farmakologicheskie svoĭstva kofermenta A-disulfida.