HbA1c in children attending summer camps organized by l'Aide aux Jeunes Diabétiques. Evidence for a harmful effect of lipohypertrophies in the early years of diabetes.
Glycated haemoglobin was determined by using the spot test method for blood sampling in all the children and teenagers attending the summer camps organized by l'Aide aux Jeunes Diabétiques in July 1989. A questionnaire was completed for each subject, relating age, the duration of the disease, the insulin regimen, the level of knowledge, the intensivity of urine and blood glucose self monitoring, and the presence of lipohypertrophies. The statistical analysis of the data suggests that the two only parameters which were found to have an influence on the level of glycated haemoglobin were the duration of the disease and the presence of lipohypertrophies: in the early years of diabetes (up to 4 years), HbA1c was significantly lower in patients without lipohypertrophies (7.90 +/- 0.18%, n = 78), than in those with lipohypertrophies (8.60 +/- 0.22%, n = 46, m +/- SEM, p < 0.02). This study should focus the attention of clinicians on the deleterious effect of lipohypertrophies, which can be observed very early on in the course of the disease.
Reach
G
G
Aide aux Jeunes Diabétiques, Paris, France.
Cahané
M
M
Vias
M
M
Papoz
L
L
Forhan
A
A
Guillemin
C
C
D000293:Adolescent; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring; D002165:Camping; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000473:pathology*; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006984:Hypertrophy; D012044:Regression Analysis; D012871:Skin Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D011795:Surveys and Questionnaires; D013997:Time Factors; D014837:Voluntary Health Agencies
D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin