[The number, distribution and effects of interleukin-2 receptor and CD4 antigens in benign and malignant lymphoproliferative diseases].
An analysis of immunophenotypes was made in benign and malignant lymphoproliferative diseases (35 cases) and short cultured lymphocytes of chronic tonsillitis (15 cases). The number, distribution and variation of interleukin-2 receptor (IL-2R, CD25) and CD4 positive cells in the above lesions were studied. The results showed that (1) there were more or less IL-2R+ and CD4+ cells presented in the tissues of benign lymphoproliferative lesions; (2) IL-2R antigen was also presented in some tumor and non-tumor cells with CD4+ reaction but it was not found in the cells with CD1+ or/and CD8+ reactions; (3) IL-2R and CD4 antigens were expressed in the proliferated lymphocytes stimulated by PHA. Although IL-2R antigen is not a specific marker to certain types of lymphocytes, it has some relations with immunophenotypes of lymphocytes. The functions and effects of IL-2, IL-2R and helper T lymphocytes were also discussed.
Liu
W
W
Su
Z
Z
Wang
L
L
Xu
S
S
Chen
Q
Q
Zhang
Z
Z
D015704:CD4 Antigens / Q000097:blood*; D002478:Cells, Cultured; D006801:Humans; D008199:Lymphadenitis / Q000276:immunology / Q000473:pathology; D008223:Lymphoma / Q000276:immunology / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer; D014069:Tonsillitis / Q000276:immunology / Q000473:pathology; D014407:Tumor Cells, Cultured
D015704:CD4 Antigens; D015375:Receptors, Interleukin-2