[Effect of verapamil with renal disease basic-prescription on hemorheology indexes of type II nephrotic syndrome].
24 cases of type II nephrotic syndrome were studied and divided randomly into two groups. Group A: 12 cases treated with verapamil; Group B: 12 cases treated with verapamil plus Renal Disease Basic-prescription (RDBP). Hemorheology indexes were measured in the two groups before and 4 weeks after the treatment. The results showed hyperviscosity was obviously improved in group A after verapamil administration (P < 0.05), but the improvement in group B was much more significant than that in group A. The results mentioned above indicate that calcium channel blocker has an anticoagulant effect with inhibiting platelet aggregation, and Peach kernel, Safflower, etc of RDBP played a role in prohibiting platelets aggregation, anticoagulation and promoting microcirculation. However the combination of the two methods has better effect in improving the hypercoagulable state of nephrotic syndrome.
Liang
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Guangdong Medical College.
Li
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D000293:Adolescent; D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012212:Rheology; D014700:Verapamil / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D014700:Verapamil