Regional chromosomal assignment of the Kell blood group locus (KEL) to chromosome 7q33-q35 by fluorescence in situ hybridization: evidence for the polypeptide nature of antigenic variation.
The gene encoding the Kell blood group polypeptide has been localized to chromosome 7q33-35 by in situ hybridization using a biotinylated 1.1-kb DNA fragment containing the 3' half of the human cDNA. This assignment is in accord with genetic localization using antigenic variation as a marker, and strongly suggests that Kell antigenic determinants are part of the polypeptide chain rather than the associated sugar molecules.
Murphy
M T
MT
Department of Biochemistry, University of Glasgow, UK.
Morrison
N
N
Miles
J S
JS
Fraser
R H
RH
Spurr
N K
NK
Boyd
E
E
D000940:Antigenic Variation; D001483:Base Sequence; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D015342:DNA Probes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007626:Kell Blood-Group System / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D015342:DNA Probes; D007626:Kell Blood-Group System