[Study of urinary excretion of testosterone and epitestosterone glucuronides in children and adolescents].
Urinary testosterone to epitestosterone ratio (T/E) is used as a marker for illegal exogenous testosterone use. Mean value in healthy adults is 1.13 and 6 is the upper limit of the accepted range. Urinary excretion of these two steroids were studied in 57 children and teenagers at different pubertal stages, using gas chromatography coupled with mass spectrometry with selective ion detection. Urinary excretion of testosterone and epitestosterone increased significantly during puberty. Mean T/E ratio remained fairly constant but interindividual variations were marked and in one subject the T/E ratio exceeded 6. These data suggest that this test may yield false-positive results in adolescents.
Raynaud
E
E
Service d'Exploration Physiologique des Hormones et des Métabolismes, Hôpital Lapeyronie, Montpellier, France.
Audran
M
M
Pages
J C
JC
Brun
J F
JF
Fedou
C
C
Chanal
J L
JL
Orsetti
A
A
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002849:Chromatography, Gas; D004300:Doping in Sports; D004845:Epitestosterone / Q000652:urine*; D005965:Glucuronates / Q000652:urine*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D013739:Testosterone / Q000652:urine*
D005965:Glucuronates; D013739:Testosterone; D004845:Epitestosterone
Etude de l'excrétion urinaire des glucuronides de testostérone et d'épitestostérone chez l'enfant et l'adolescent.