[Anti-ischemic therapy with verapamil. Improving prognosis by secondary prevention after acute myocardial infarct].
Calcium antagonists reduce myocardial oxygen demand and increase the oxygen supply to the myocardium via a coronary dilating effect. For the treatment of silent myocardial ischämia and of stable and instable angina pectoris, studies with verapamil revealed an anti-ischemic efficacy comparable with that of beta blockers and nitrates. Studies of secondary prophylaxis after acute myocardial infarction reveal a cardioprotective effect of verapamil in terms of a reduction in mortality and re-infarction rates. Calcium antagonists have further organ-protective effects such as a reduction of left ventricular wall hypertrophy and a slowing effect on the progression of arteriosclerotic vascular changes.
Dotzer
F
F
Medizinische Abteilung, Krankenhaus München-Perlach.
Gromer
H
H
D003326:Coronary Circulation / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000401:mortality; D009566:Nitrates / Q000627:therapeutic use; D011379:Prognosis; D014700:Verapamil / Q000009:adverse effects / Q000627:therapeutic use*
D009566:Nitrates; D014700:Verapamil
Antiischämische Therapie mit Verapamil. Prognoseverbesserung durch Sekundärprophylaxe nach akutem Myokardinfarkt.