title: Two sisters with multiple sclerosis, lamellar ichthyosis, beta thalassaemia minor and a deficiency of factor VIII.
abstract: Two of four sisters have multiple sclerosis (MS), lamellar ichthyosis, beta thalassaemia minor and a quantitative deficit of factor VIII-von Willebrand complex. The mother and the other sisters have only beta thalassaemia minor. The association of MS and a cluster of genetically determined diseases is rare. Such families could offer a new approach to the investigation of the polygenetic background of MS.
authors.affiliation: Institute of Clinical Neurology, University of Brescia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Capra
authors.forename: F
authors.initials: F
authors.lastname: Mattioli
authors.forename: B
authors.initials: B
authors.lastname: Kalman
authors.forename: N
authors.initials: N
authors.lastname: Marcianò
authors.forename: A
authors.initials: A
authors.lastname: Berenzi
authors.forename: A
authors.initials: A
authors.lastname: Benetti
mesh_terms: D000328:Adult; D005190:Family; D005260:Female; D006467:Hemophilia A / Q000150:complications / Q000235:genetics*; D006801:Humans; D017490:Ichthyosis, Lamellar / Q000150:complications / Q000235:genetics*; D009103:Multiple Sclerosis / Q000150:complications / Q000235:genetics*; D010375:Pedigree; D017086:beta-Thalassemia / Q000150:complications / Q000235:genetics*