Prognostic value of Helix pomatia in breast cancer. International (Ludwig) Breast Cancer Study Group.
Six hundred and eighty-four primary breast cancers from the International (Ludwig) Breast Cancer Study Group (IBCSG) were studied for Helix pomatia lectin (HPA) binding. There was a weak correlation between lymph node-positive and HPA positive (P = 0.04). In our series there was a large advantage in disease-free survival (DFS) and overall survival (OS) for node-negative patients (P < 0.0001 DFS and OS). However, there was no such advantage for HPA-negative patients (P = 0.23 DFS and P = 0.32 OS). We conclude that in this randomised patient group HPA is of no clinical predictive value.
D000116:Acetylgalactosamine / Q000032:analysis; D000328:Adult; D000818:Animals; D001940:Breast / Q000098:blood supply / Q000166:cytology / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006372:Helix, Snails; D006801:Humans; D037102:Lectins; D008593:Menopause; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D016019:Survival Analysis; D013997:Time Factors
C038095:Helix lectin; D037102:Lectins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D000116:Acetylgalactosamine