Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation.
The effect of 5-HT3 receptor antagonists such as ondansetron, ICS 205-930, MDL 72222, metoclopramide, and zacopride was investigated on the ethanol as well as diazepam withdrawal phenomena in the present study. There was a significant increase in locomotor activity in the ethanol- as well as diazepam-withdrawn rats. The treatment of rats with 5-HT3 receptor antagonists during withdrawal phase did not modify the effect. The ethanol-withdrawn rats were more sensitive to pentylenetetrazole (PTZ)-induced convulsions as compared to control animals. 5-HT3 receptor antagonists did not attenuate the increased sensitivity of ethanol-withdrawn rats to PTZ. These observations indicated that 5-HT3 receptor antagonists are ineffective in attenuating hyperlocomotor activity following abrupt termination of chronic administration of ethanol or diazepam, and increased sensitivity to PTZ in the ethanol-withdrawn rats.
Mehta
A K
AK
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
Ticku
M K
MK
D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced; D012702:Serotonin Antagonists; D013268:Stimulation, Chemical; D013375:Substance Withdrawal Syndrome / Q000523:psychology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D000431:Ethanol; D003975:Diazepam; D010433:Pentylenetetrazole