title: Synthesis of some new thioethers of 1,2,4-triazine-3-hydrazones and assays for their anticancer and anti human immune virus activities.
abstract: A number of various thioethers derived from 3-hydrazone-5,6-diphenyl-1,2,4-triazines have been synthesized and evaluated for anticancer and anti HIV activities. The structures are supported by elemental analysis, IR, UV and 1H-NMR spectral data. Most of the tested compounds displayed a significant activity against Leukemia/Lymphoma, CNS, Ovarian and Small cell lung cancer.
authors.affiliation: Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt.
authors.forename: R M
authors.initials: RM
authors.lastname: Abdel-Rahman
authors.forename: M
authors.initials: M
authors.lastname: Seada
authors.forename: M
authors.initials: M
authors.lastname: Fawzy
authors.forename: I
authors.initials: I
authors.lastname: el-Baz
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006678:HIV / Q000187:drug effects*; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D006835:Hydrazones; D014227:Triazines