title: Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice.
abstract: Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.
authors.affiliation: National Center for Toxicological Research, Jefferson, AR 72079.
authors.forename: P P
authors.initials: PP
authors.lastname: Fu
authors.forename: K L
authors.initials: KL
authors.lastname: Dooley
authors.forename: L S
authors.initials: LS
authors.lastname: Von Tungeln
authors.forename: T
authors.initials: T
authors.lastname: Bucci
authors.forename: R W
authors.initials: RW
authors.lastname: Hart
authors.forename: F F
authors.initials: FF
authors.lastname: Kadlubar
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics; D002911:Chrysenes / Q000493:pharmacokinetics; D004249:DNA Damage; D002149:Energy Intake; D005508:Food Deprivation; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice
chemical_list: D002273:Carcinogens; D002911:Chrysenes; C035986:6-nitrochrysene