title: Hereditary spastic paraplegia associated with epilepsy, mental retardation and hearing impairment.
abstract: Epilepsy rarely occurs in patients with hereditary spastic paraplegia (HSP), and is not included in the description of the 'complicated' form of HSP by Harding. We report 3 patients with HSP in a family of two generations. Two of them also had epilepsy, mental retardation and hearing impairment. The disorder was inherited as an autosomal dominant trait.
authors.affiliation: Neurological Institute, Veterans General Hospital-Taipei, Taiwan, Republic of China.
authors.forename: J S
authors.initials: JS
authors.lastname: Yih
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: M S
authors.initials: MS
authors.lastname: Su
authors.forename: S C
authors.initials: SC
authors.lastname: Tsai
authors.forename: R H
authors.initials: RH
authors.lastname: Lin
authors.forename: K N
authors.initials: KN
authors.lastname: Lin
authors.forename: H C
authors.initials: HC
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000235:genetics; D005190:Family; D005260:Female; D006311:Hearing Disorders / Q000150:complications* / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000150:complications* / Q000235:genetics; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D015419:Spastic Paraplegia, Hereditary / Q000150:complications* / Q000235:genetics