Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.
The activation of the secretory pathway for the amyloid protein precursor (APP) by phorbol 12-myristate 13-acetate in human glioblastoma A-172 cells leads to a decrease in intracellular beta-amyloidogenic fragments derived from APP. The result suggests that a metabolic switch of APP from the endosomal/lysosomal pathway to a secretion route occurs after PMA treatment.
Fukushima
D
D
Minase Research Institute, Ono Pharmaceutical Co. Ltd., Osaka, Japan.
Konishi
M
M
Maruyama
K
K
Miyamoto
T
T
Ishiura
S
S
Suzuki
K
K
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000470:Alkaloids / Q000494:pharmacology; D016564:Amyloid beta-Protein Precursor / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D005910:Glioma; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D007700:Kinetics; D008970:Molecular Weight; D010446:Peptide Fragments / Q000302:isolation & purification / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D047428:Protein Kinase Inhibitors; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000302:isolation & purification; D019311:Staurosporine; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014162:Transfection; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D016564:Amyloid beta-Protein Precursor; D007546:Isoquinolines; D010446:Peptide Fragments; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011994:Recombinant Proteins; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D011493:Protein Kinase C; D019311:Staurosporine; D013755:Tetradecanoylphorbol Acetate