[The effect of kobazol and atsizol on the proliferation of mononuclear cells].
The authors studied the new imidazole-containing drugs cobazole and acizole for their effects on the proliferation of mononuclear cells from donors and patients with rheumatic arthritis. Acizole was found to produce no effects on mononuclear cell proliferation, whereas cobazole inhibited only the increased spontaneous proliferation of mononuclear cells in patients with rheumatic arthritis, which was due to a higher activity of nonspecific T-suppressor lymphocytes.
Shirinskiĭ
V S
VS
Zhuk
E A
EA
Domnina
E S
ES
Baĭkalova
L A
LA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000097:blood; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D003035:Cobalt / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000187:drug effects; D015032:Zinc / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D007093:Imidazoles; D008934:Mitogens; D009942:Organometallic Compounds; C085862:kobazol; C085860:atsizol; D003035:Cobalt; D015032:Zinc
Vliianie kobazola i atsizola na proliferatsiiu mononuklearnykh kletok.