title: Wave V latency shifts with age and sex in normals and patients with cochlear hearing loss: development of a predictive model.
abstract: In order to study the combined effect of age, sex and cochlear hearing loss on the auditory brainstem response in an adult population, absolute wave V latency measurements were made in 117 ears of 64 patients with cochlear hearing loss and 105 ears of 58 otologically normal control subjects. Among normals, wave V latency was found to increase with age. Latencies in female subjects were significantly shorter than in male subjects. The best predictive model for wave V latency in normals was: wave V latency (ms) = 4.982 + 0.007 x age + 0.091 x sex, where age is measured in years and sex is given a value of 1 for females and 2 for males. In patients with hearing loss, wave V latency increase was determined largely by the degree of hearing loss and the effect of age was moderate. The influence of sex was minimal. Wave V latency in patients with hearing loss was predicted by the formula: wave V latency (ms) = 4.911 + 0.007 x hearing loss + 0.004 x age + 0.081 x sex. These predictive models can be utilized to accurately estimate expected wave V latency in patients with cochlear hearing loss.
authors.affiliation: Department of Otolaryngology, Christian Medical College and Hospital, Vellore, India.
authors.forename: V
authors.initials: V
authors.lastname: Rupa
authors.forename: A K
authors.initials: AK
authors.lastname: Dayal
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D015834:Cochlear Diseases / Q000175:diagnosis* / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors