The power of systematic genealogical study in familial Alzheimer disease.
Several kindreds (N, C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.
Bruni
A C
AC
USSL 17, Lamezia Terme.
Montesi
M P
MP
Rainero
I
I
Ferini-Strambi
L
L
Macciardi
F
F
Pinessi
L
L
Gei
G
G
Fragiacomo
D
D
Bergamini
L
L
D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree