Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets.
Familial Alzheimer diseases is a neurological disorder of adult onset. Three research centers have each contributed their families and genetic linkage data for combined analyses. The data from the Duke and Boston centers, comprising 73 pedigrees for whom numerous markers on chromosomes 19 and 21 were typed are described.
Pericak-Vance
M A
MA
Division of Neurology, Duke University Medical Center, Durham, NC 27710.
St George-Hyslop
P H
PH
Gaskell
P C
PC
Growdon
J
J
Crain
B J
BJ
Hulette
C
C
Gusella
J F
JF
Yamaoka
L
L
Tanzi
R E
RE
Roses
A D
AD
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001900:Boston / Q000453:epidemiology; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D010375:Pedigree
D005819:Genetic Markers