title: Serum interleukin-1 alpha and soluble interleukin-2 receptor concentrations in cystic fibrosis.
abstract: Interleukin (IL)-1 and IL-2 may participate in the systemic inflammatory response and hypergammaglobulinaemia observed in patients with cystic fibrosis. Thirty seven patients with cystic fibrosis were compared with 25 normal controls. High IgG and IgM concentrations were associated with more severe pulmonary disease. IL-1 alpha and soluble IL-2 receptor concentrations were higher in the cystic fibrosis group than in the controls and also correlated with concentrations of IgG and IgM. These results suggest that these cytokines may contribute to enhanced immunoglobulin synthesis and silent inflammatory activity in clinically stable patients with cystic fibrosis.
authors.affiliation: Department of Child Health, King's College Hospital, London.
authors.forename: P
authors.initials: P
authors.lastname: Greally
authors.forename: M J
authors.initials: MJ
authors.lastname: Hussain
authors.forename: D
authors.initials: D
authors.lastname: Vergani
authors.forename: J F
authors.initials: JF
authors.lastname: Price
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005541:Forced Expiratory Volume; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007375:Interleukin-1 / Q000378:metabolism*; D008168:Lung / Q000503:physiopathology; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D014797:Vital Capacity
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1; D015375:Receptors, Interleukin-2