Study of potassium citrate treatment of crystalluric nephrolithiasis.
Patients with crystalluric nephrolithiasis were treated orally with aqueous potassium citrate solution three times a day with a large quantity of water. After administration of potassium citrate, citric acid (P < 0.001) and potassium (P < 0.001) excretion was significantly increased. Increase in protein (P < 0.05) and uric acid (P < 0.05) excretion in urine revealed their association with the crystallization process. Crystals were absent in 12 (71%) out of 17 patients. Calcium excretion in urine was significantly decreased (P < 0.05). A decrease of calcium ions availability to oxalate ions to form calcium oxalate crystals may result in the prevention of calcium oxalate stone formation.
Khanniazi
M K
MK
Department of Nephro-Urology, Jinnah Post Graduate Medical Centre, University of Karachi, Pakistan.
Khanam
A
A
Naqvi
S A
SA
Sheikh
M A
MA
D000328:Adult; D000863:Antacids / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D002951:Citrates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019343:Citric Acid; D003460:Crystallization; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000188:drug therapy*; D008297:Male; D011507:Proteinuria / Q000139:chemically induced; D014527:Uric Acid / Q000652:urine
D000863:Antacids; D002951:Citrates; D014527:Uric Acid; D019343:Citric Acid; D002118:Calcium