Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse.
To investigate the effects of angiotensin-converting enzyme (ACE) inhibitors on the cellular function and structure in a variety of organs during the aging process, one hundred CF1 mice were divided into four groups of 25 animals each. Groups A, B, and C received enalapril in drinking water from weaning until the age of 24 mo. Doses administered were (in mg/l): group A, 20; group B, 10; group C, 5. Group D is the control. Animals were killed, and morphometric studies were performed in heart, kidney, liver, and spleen. As a result, there was a decrease of renal and myocardial sclerosis and an increase in the number of mitochondria in heart and liver cells, which is associated with a significant increase in survival of animals receiving ACE inhibitors. These findings lead us to think that natural aging mechanisms have been altered in those animals.
Ferder
L
L
Institute of Nephrology, Jewish Hospital, University of Buenos Aires, Argentina.
Inserra
F
F
Romano
L
L
Ercole
L
L
Pszenny
V
V
D000375:Aging / Q000502:physiology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000648:ultrastructure
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril