title: Genetic structure in the Garfagnana (Tuscany, Italy): a study of eight protein markers by isoelectric focusing.
abstract: The genetic structure of the human population in a random sample of 238 unrelated individuals from Garfagnana (Tuscany, Italy) was studied for five highly polymorphic serum proteins (GC, TF, PI, AHSG, ORM1) and three red cell isozymes (ACP, PGM1, ESD) by isoelectric focusing. Comparison with the gene frequencies from other districts of Tuscany has shown no significant deviation in seven out of eight polymorphic protein systems. Subtype allele frequencies of orosomucoid 1 (ORM1), which were not yet determined in Italian populations, are as follow: ORM1*F1 = 0.586, ORM1*F2 = 0.021, and ORM1*S = 0.393. The most striking features of this unique sample were the relatively high frequencies of PGM1*2B (0.093) and PI*I (0.013) alleles.
authors.affiliation: Institut für Anthropologie und Humangenetik, Universität München, BRD.
authors.forename: S
authors.initials: S
authors.lastname: Weidinger
authors.forename: R
authors.initials: R
authors.lastname: Hallwachs
authors.forename: G
authors.initials: G
authors.lastname: Paoli
authors.forename: R
authors.initials: R
authors.lastname: Stanyon
mesh_terms: D000483:Alleles; D001798:Blood Proteins / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D007525:Isoelectric Focusing; D007527:Isoenzymes / Q000097:blood / Q000235:genetics*; D007558:Italy
chemical_list: D001798:Blood Proteins; D005819:Genetic Markers; D007527:Isoenzymes