title: Somatostatin receptor scintigraphy in malignant lymphoma: first results and comparison with glucose metabolism measured by positron-emission tomography.
abstract: Somatostatin receptor scintigraphy with 111In-labeled octreotide was performed in 22 patients with suspected or known malignant lymphoma. The majority of extra-abdominal lesions (21/24 = 87.5%) were correctly localized, however, only one of nine intraabdominal lymphomas could be detected. No significant correlation was found between scintigraphic results and histological type of lymphoma. Metabolic imaging by positron-emission tomography with 18F-labeled deoxyglucose yielded a higher rate of detection of lymphoma manifestations (92% vs 64%) and better tumor contrast. Further prospective studies are needed to establish the clinical relevance of somatostatin receptor scintigraphy in malignant lymphoma.
authors.affiliation: Department of Nuclear Medicine, Technical University of Aachen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Bares
authors.forename: P
authors.initials: P
authors.lastname: Galonska
authors.forename: W
authors.initials: W
authors.lastname: Dempke
authors.forename: S
authors.initials: S
authors.lastname: Handt
authors.forename: U
authors.initials: U
authors.lastname: Büll
authors.forename: R
authors.initials: R
authors.lastname: Osieka
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006099:Granuloma / Q000000981:diagnostic imaging; D006689:Hodgkin Disease / Q000000981:diagnostic imaging; D006801:Humans; D006965:Hyperplasia; D007205:Indium Radioisotopes; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging; D008297:Male; D015282:Octreotide / Q000031:analogs & derivatives; D004369:Pentetic Acid / Q000031:analogs & derivatives; D010954:Plasmacytoma / Q000000981:diagnostic imaging; D017481:Receptors, Somatostatin / Q000032:analysis*; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D005462:Fluorine Radioisotopes; D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D019788:Fluorodeoxyglucose F18; C071632:SDZ 215-811; D004369:Pentetic Acid; D003847:Deoxyglucose; D005947:Glucose; D015282:Octreotide