title: Age-related digoxin-alprazolam interaction.
abstract: A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpatients receiving long-term digoxin (0.25 mg daily) randomly received oral administration of either 1.0 or 0.5 mg alprazolam per day for 7 days. In each dosage group, three patients were older than and three were younger than 65 years of age. The area under the concentration-time curve for serum digoxin increased significantly in patients receiving 1 mg alprazolam daily, and this increase was more pronounced in patients older than 65 years of age. Clinical digoxin toxicity developed in one elderly patient who was receiving 1 mg/day alprazolam.
authors.affiliation: Department of Pharmacology, Dokuz Eylul University Hospital, Inciralti, Izmir, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Guven
authors.forename: Y
authors.initials: Y
authors.lastname: Tuncok
authors.forename: S
authors.initials: S
authors.lastname: Guneri
authors.forename: C
authors.initials: C
authors.lastname: Cavdar
authors.forename: J
authors.initials: J
authors.lastname: Fowler
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D000525:Alprazolam / Q000494:pharmacology*; D004077:Digoxin / Q000097:blood / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008875:Middle Aged
chemical_list: D004077:Digoxin; D000525:Alprazolam