title: Transforming growth factor-beta in rat kidney during compensatory renal growth.
abstract: Transforming growth factor-beta (TGF-beta) inhibits the DNA synthesis and stimulates the alkaline phosphatase activity of cultured renal cortical tubular cells. When unilateral nephrectomy was performed, TGF-beta activity content gradually decreased in the remaining kidney. An immunohistochemical study of the remaining kidney after uninephrectomy, however, showed that the expression of TGF-beta increased by the third day after uninephrectomy in the proximal tubular cells and an autoradiographic study revealed that TGF-beta expressing tubular cells were different from proliferating cells during compensatory renal growth. These results indicate that the total renal TGF-beta content decreases after uninephrectomy, while the expression of TGF-beta in the proximal tubular cells may increase and act as a brake for compensatory renal hyperplasia.
authors.affiliation: Department of Urology, Nagasaki University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kanda
authors.forename: T
authors.initials: T
authors.lastname: Igawa
authors.forename: M
authors.initials: M
authors.lastname: Taide
authors.forename: J
authors.initials: J
authors.lastname: Eguchi
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Nomata
authors.forename: J
authors.initials: J
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Kanetake
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D015151:Immunoblotting; D007150:Immunohistochemistry; D007668:Kidney / Q000254:growth & development* / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta