The development of dermatitis infiltrated by gamma delta T cells in IL-7 transgenic mice.
Transgenic mice constitutively expressing IL-7 developed severe dermatitis with erythroderma and alopecia. The skin lesions were characterized by massive infiltration of mononuclear cells. Immunofluorescence staining showed that most of the infiltrating cells were T cells with the majority bearing the gamma delta TCR other than the V gamma 5 moiety. Furthermore, the number of gamma delta T cells had increased in the lymphoid organs of the dermatitis animals. These findings indicate the strong relationship between the expression of IL-7 and the development of gamma delta T cells in vivo and the pathological involvement of proliferated and/or activated gamma delta T cells in skin disease.
Uehira
M
M
Shionogi Research Laboratories, Shionogi & Co., Ltd, Osaka, Japan.
Matsuda
H
H
Hikita
I
I
Sakata
T
T
Fujiwara
H
H
Nishimoto
H
H
D000818:Animals; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D002465:Cell Movement; D003872:Dermatitis / Q000276:immunology* / Q000473:pathology; D005434:Flow Cytometry; D007150:Immunohistochemistry; D015851:Interleukin-7 / Q000096:biosynthesis / Q000097:blood / Q000502:physiology*; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013601:T-Lymphocytes / Q000502:physiology*
D000911:Antibodies, Monoclonal; D015851:Interleukin-7; D016692:Receptors, Antigen, T-Cell, gamma-delta