title: Ultrastructure of plasma cells in a patient with J chain disease.
abstract: Ultrastructural analysis of plasma cells was performed in a 74-year-old female patient with J chain disease. By electron microscopy, various characteristic findings were observed: lobulated nuclei, multinuclei, single sac loop-like structures, flocculent filament-like substances, nuclear inclusion bodies, cytoplasmic inclusion bodies, and multilamellar bodies. Our prior studies pointed out a poor prognosis in myeloma patients with these findings.
authors.affiliation: Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sawamura
authors.forename: H
authors.initials: H
authors.lastname: Kurabayashi
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Sakura
authors.forename: J
authors.initials: J
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Naruse
authors.forename: J
authors.initials: J
authors.lastname: Tsuchiya
mesh_terms: D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007072:Immunoglobulin D / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M / Q000097:blood; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D010950:Plasma Cells / Q000648:ultrastructure*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M; D003520:Cyclophosphamide; D011239:Prednisolone