Developmental expression of major myelin proteins in hypomyelinated pt mutant rabbit.
A term "paralytic tremor" (pt) is attributed to a neurological mutation of Chinchilla rabbits, affecting the development of the central nervous system (CNS). A quantification of myelin protein content indicates the strong CNS hypomyelination during the development (1-120 postnatal days). SDS-PAGE electrophoresis of total brain homogenates, followed by immunoblotting, shows a reduced concentration of major myelin-connected proteins. MBP deficiency corresponds approximately to the level of the hypomyelination, whereas PLP expression is drastically reduced.
Sypecka
J
J
Department of Neurochemistry, Medical Research Center, Polish Academy of Sciences, Warsaw.
Tosic
M
M
Dolivo
M
M
Domańska-Janik
K
K
Matthieu
J M
JM
D000375:Aging / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry; D002682:Chinchilla; D003711:Demyelinating Diseases / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009185:Myelin Proteins / Q000096:biosynthesis*; D011817:Rabbits
D009185:Myelin Proteins