[The action of sulfur-containing and methemoglobin-forming compounds in renal ischemia].
Rat experiments demonstrated that cystamine showed a dose-dependent effect in renal ischemia. Ischemia was induced by ligation of renal vessels and the ureter for 90 minutes. Unithiol given in a single dose before ischemia produced no protective effect. Preadministration of sodium nitrite in doses causing slight to moderate hemic hypoxia could not diminish reoxygenation ischemic lesions.
Vorob'eva
N D
ND
Anikin
G D
GD
D000818:Animals; D003538:Cystamine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000139:chemically induced; D007511:Ischemia / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply*; D008706:Methemoglobin / Q000187:drug effects*; D051381:Rats; D012977:Sodium Nitrite / Q000627:therapeutic use*; D014494:Unithiol / Q000627:therapeutic use*
D014494:Unithiol; D008706:Methemoglobin; D012977:Sodium Nitrite; D003538:Cystamine
Deĭstvie serosoderzhashchikh i metgemoglobinobrazuiushchikh soedineniĭ pri ishemii pochki.