Penetration of rifampicin into the brain tissue and cerebral extracellular space of rats.
Rifampicin is used to treat neurosurgical shunt infections because of its excellent in-vitro activity against staphylococci and its adequate penetration into the CSF. However, nothing is known about rifampicin concentrations in the cerebral extra-cellular space (CES). We measured the penetration of rifampicin into the CES of anaesthetized rats by microdialysis using low-flow and equilibrium methods. Depending on the method, rifampicin concentrations in the CES were 0.3-1% of the serum concentration or 3-8% of brain tissue concentration, respectively. These experimental data in animals suggest that the recommended dose of rifampicin in man might be inadequate for treatment of some brain infections.
Mindermann
T
T
Neurosurgical University Clinics, University Hospitals Basle, Switzerland.
Landolt
H
H
Zimmerli
W
W
Rajacic
Z
Z
Gratzl
O
O
D000818:Animals; D001681:Biological Assay; D001921:Brain / Q000378:metabolism*; D003956:Dialysis; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012293:Rifampin / Q000493:pharmacokinetics* / Q000494:pharmacology; D012505:Sarcina / Q000187:drug effects
D012293:Rifampin