title: In-vivo and in-vitro sensitivity of Plasmodium falciparum to chloroquine at Indian Oil Corporation, Mathura (U.P.).
abstract: In vivo and in vitro susceptibility of Plasmodium falciparum to chloroquine were conducted at Indian Oil Corporation (IOC), Mathura, India. 18 out of 31 cases showed resistance [minimum inhibitory concentration (MIC) 8 pmol] in in vitro study. EC50 and EC90 values estimated from log-probit analysis for resistant isolates were 0.66 and 1.44 microM/litre, and for sensitive isolates 0.28 and 0.96 microM/litre blood respectively. In vivo tests identified 13 cases (40.62%) as resistant and 19 cases (59.73%) as sensitive out of 32 cases. All the cases belonged to IOC, Mathura complex, or its vicinity.
authors.affiliation: Malaria Research Centre (Field Station), BHEL Complex, Ranipur, Hardwar, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Dua
authors.forename: P K
authors.initials: PK
authors.lastname: Kar
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: V P
authors.initials: VP
authors.lastname: Sharma
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006801:Humans; D007194:India; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development
chemical_list: D002738:Chloroquine