title: A semiconductor silicon PIN diode matrix detector for measurement of 133Xe washout in small regional skin areas.
abstract: Local variations in microvascularization are expected in lesions and lesion-free skin of patients with pressure sores. To investigate these variations, methods for studies of the regional blood flow rate within small skin areas are needed. Regional blood flow can be estimated by measuring the washout of 133Xe from the tissue. This study describes a 2 x 12 Si PIN diode matrix detector capable of 133Xe detection, and equipped with a collimator to improve the spatial resolution. Thus the regional blood flow in subcutaneous skin areas down to about 2 cm2 can be investigated when the atraumatic epicutaneous labelling technique is used. The capability of the matrix detector and its collimator is described by laboratory investigations. In pilot investigations three normal subjects and three paraplegics with pressure sores were studied. In each individual study the detector matrix was divided into six square areas containing four diode detectors each. Thus six 133Xe disappearance rate constants from adjacent subcutaneous tissue could be determined simultaneously.
authors.affiliation: Department of Biomedical and Clinical Engineering, University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: J H
authors.initials: JH
authors.lastname: Jensen
authors.forename: J L
authors.initials: JL
authors.lastname: Sørensen
authors.forename: E N
authors.initials: EN
authors.lastname: Hauge
authors.forename: P
authors.initials: P
authors.lastname: Sejrsen
authors.forename: J
authors.initials: J
authors.lastname: Bojsen
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D010264:Paraplegia / Q000150:complications*; D003668:Pressure Ulcer / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes