Production and role of macrophage colony stimulating factor (CSF-1 or M-CSF) in hematological pathology.
M-CSF, an homodimeric glycoprotein initially identified as a Colony Stimulating Factor, can now be considered as a cytokine-produced by multiple cell types, including T cells and acting on hematological and non hematological tissues. In this short article, we bring evidence that the production of M-CSF is inducible in T cells in vitro and in vivo and that it plays a central role in several hematological disorders. A particular emphasis will be given to EBV induced hemophagocytic syndromes and to related disorders during the oral presentation.
Praloran
V
V
Laboratoire d'Hématologie Expérimentale, Faculté de Médecine, Limoges, France.
Mechinaud-Lacroix
F
F
D000818:Animals; D006402:Hematologic Diseases / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000502:physiology
D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor