Immunological responses in an infant after cyclosporine A exposure during pregnancy.
Pregnancy in transplant recipients is not uncommon. Cyclosporin A may be used as an immunosuppressive drug in these patients. Almost no data exist on the effects of cyclosporin A on the immune system of infants who have been exposed to this drug in utero. The infant of a liver transplant recipient was followed during the first 2 years of life. Shortly after birth all lymphocyte subsets were low, especially for B-cells. The distribution of lymphocytes returned to low normal ranges within the first 2 years of life, except for CD8 values that stayed below normal. There were no signs of persistent adverse effects of cyclosporin A on the functional integrity of the immune system.
Baarsma
R
R
Department of Paediatrics, University Hospital, Groningen, The Netherlands.
Kamps
W A
WA
D016175:B-Lymphocyte Subsets / Q000187:drug effects*; D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007231:Infant, Newborn / Q000097:blood / Q000276:immunology*; D007958:Leukocyte Count; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013601:T-Lymphocytes / Q000187:drug effects*
D016572:Cyclosporine