Bacterial vaginosis and prematurity in Indonesia: association in early and late pregnancy.
OBJECTIVE
Our objective was to examine the association between preterm delivery and bacterial vaginosis in early and late pregnancy.


METHODS
We evaluated 490 pregnant women at three hospitals in Jakarta, Indonesia, for bacterial vaginosis at 16 to 20 weeks' and 28 to 32 weeks' gestation and observed them through delivery.


RESULTS
We found significant associations between preterm delivery (gestational age < 37 weeks) and bacterial vaginosis diagnosed at 16 to 20 weeks' gestation (odds ratio 2.0, 95% confidence interval 1.0 to 3.9) but not with bacterial vaginosis diagnosed at 28 to 32 weeks' gestation (odds ratio 1.5, 95% confidence interval 0.7 to 3.0). The rates of preterm delivery were almost doubled for women who had bacterial vaginosis in early pregnancy (20.5%) as compared with women who had bacterial vaginosis only in late pregnancy (10.7%).


CONCLUSIONS
Only bacterial vaginosis diagnosed early in the second trimester of pregnancy plays a major role as a risk factor for preterm delivery.
Riduan
J M
JM
Division of Sexually Transmitted Diseases/Human Immunodeficiency Virus Prevention, Centers for Disease Control, Atlanta, GA 30333.
Hillier
S L
SL
Utomo
B
B
Wiknjosastro
G
G
Linnan
M
M
Kandun
N
N
D000328:Adult; D000367:Age Factors; D004522:Educational Status; D005260:Female; D005865:Gestational Age; D006801:Humans; D007214:Indonesia; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000382:microbiology*; D011247:Pregnancy; D012307:Risk Factors; D012907:Smoking; D013997:Time Factors; D014245:Trichomonas Infections; D016585:Vaginosis, Bacterial / Q000150:complications*