title: [A decrease in the hydrodynamic resistance in the mesenteric arterioles of rats injected with the polyethylene oxide Polyox WSR-301].
abstract: The infusion of polyethylene oxide in anesthetised rats in a total dose of 10(-7) g/ml caused a 10-16% reduction in blood pressure. This injection has been associated with 17% decreased pressure (servo-nulling method) and 54% increased blood velocity (laser Doppler fluxmetry) in mesenteric arterioles (d - about 24 mu), but no increase in their internal diameter was observed (image-split method). Vasodilatation (adenosine, 10(-5) M) did not change the hemodynamic response of the arterioles to polymer infusion. These results suggest that microdisturbances of blood flow which can be diminished by drug-reducing polymers are more important for the vascular resistance to blood than it has been previously.
authors.forename: I A
authors.initials: IA
authors.lastname: Sokolova
authors.forename: A A
authors.initials: AA
authors.lastname: Shakhnazarov
authors.forename: M I
authors.initials: MI
authors.lastname: Timkina
authors.forename: M S
authors.initials: MS
authors.lastname: Poliakova
authors.forename: A V
authors.initials: AV
authors.lastname: Priezzhev
authors.forename: S G
authors.initials: SG
authors.lastname: Proskurin
authors.forename: N B
authors.initials: NB
authors.lastname: Savchenko
authors.forename: K F
authors.initials: KF
authors.lastname: Bikkulova
mesh_terms: D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000502:physiology; D055592:Biophysical Phenomena; D001703:Biophysics; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000502:physiology; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D011092:Polyethylene Glycols
vernacular_title: Umen'shenie gidrodinamicheskogo soprotivleniia v arteriolakh bryzheĭki krys pri in''ektsii poliétilenoksida Polyox WSR-301.