[Changes in renal cortical thromboxane A2, prostaglandin F1 alpha and effects of dazoxiben, chuan xiong on in situ immune complex glomerulonephritis in rats].
We investigated the relation between the changes of TXA2-PG1 alpha balance and glomerular injury, and the effects of Dazoxiben, Chuan Xiong on in situ immune complex glomerulonephritis (ISICGN) produecd by C-BSA in rats. After two weeks of immunization, the level of renal cortical TXB2 and urine protein was increased, while that of 6-keto-PGF1 alpha was decreased. Four weeks later, the changes as mentioned above were more significant, and platelet aggregation revealed an increase of maximal aggregation. Positive correlation was seen between urine protein and renal cortical TXA2, and negative correlation between urine protein and 6-keto-PGF1 alpha. Histological examination showed morphological changes. Two treated-groups showed significant reduction of urine protein and renal cortical TXB2, but increase of 6-keto-PGF1 alpha. Besides the changes like worm-eaten in electron-dense deposits, foot process fusion disappeared. The thickened GBM and mesangial proliferation were lessened, especially in Dazoxiben group. These results suggests that there is a TXA2-PG1 alpha imbalance in ISICGN, and TXA2 plays an important pathogenetic role in the onset and progression of glomerulonephritis. Dazoxiben and Chuan Xiong might improve TXA2-PG1 alpha imbalance and attenuate glomerular injury to some extent in ISICGN.
Yuan
W
W
Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012710:Serum Albumin, Bovine; D013929:Thromboxane B2 / Q000378:metabolism*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D000936:Antigen-Antibody Complex; D004365:Drugs, Chinese Herbal; D007093:Imidazoles; C029166:dazoxiben; D012710:Serum Albumin, Bovine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D013930:Thromboxane-A Synthase