[Nonbacterial thrombotic endocarditis--a study of 171 case reports].
A descriptive term nonbacterial thrombotic endocarditis (NBTE) is used currently instead of the former name marantic endocarditis. The study describes 171 cases of NBTE encountered in autopsies over a period of 22 years (an incidence of 0.93% in adults). Malignancy was present in 59% of cases. Tumors relatively most frequently associated with NBTE were carcinomas of the ovaries, biliary system, pancreas, lung, and stomach. The vegetations were located mostly on the left-sided valves (mitral 64%, aortic 24%, both 9%). The involved valves were otherwise normal in 82%, and they were previously damaged in 18%. Systemic emboli from valvular vegetations occurred in 41% of patients, with splenic, cerebral, and renal circulations being most frequently affected. Pulmonary embolism was noted in 43%. The state of nutrition at autopsy was within normal limits in 35%; there was undernourishment or cachexia in 40%, and overweight or obesity in 22% of patients. The main pathogenetic factor in NBTE seems to be a state of hypercoagulation.
Steiner
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Fingerlandův ústav patologie LF UK, Hradec Králové.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004696:Endocarditis / Q000150:complications / Q000473:pathology*; D006351:Heart Valves / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D013927:Thrombosis / Q000150:complications / Q000473:pathology*
Nebakteriální trombotická endokarditida--studie 171 prípadu.