[Sleepiness. Experimental models].
Some experimental models of sleepiness are reviewed. The model of the narcoleptic dog is the best one to study the mechanisms of cataplexy. Idiopathic sleepiness can be experimentally studied by acting upon either circadian or homeostatic regulation of sleep. The paradoxical sleep rebound which occurs after its previous suppression has been explained by different theories which are summarized. Finally, the decrease of waking which follows either lesion or pharmacological alterations is useful to develop new molecules which can increase waking, in a safe manner.
Jouvet
M
M
Département de médecine expérimentale, Faculté de médecine, Lyon, France.
D000818:Animals; D001143:Arousal / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*
La somnolence. Modèles expérimentaux.