Transfusion-associated graft-versus-host disease in an immunocompetent patient following accidental injury.
We report a case of transfusion-associated graft-vs.-host disease (TA-GVHD) in a previously healthy, 58 year old Japanese man following an accidental injury. Despite intensive treatment, the patient died 22 days after the transfusion. Although many cases of fatal TA-GVHD have been reported in immunocompetent patients, only two are known to have developed this disorder unrelated to a surgical procedure. This is the first such case to be confirmed by HLA typing. Our report suggests that TA-GVHD can occur even in a healthy, immunocompetent recipient. Thus, it seems necessary to establish guidelines for the irradiation of cellular blood products before transfusion.
Kobayashi
H
H
Second Department of Internal Medicine, Shinshu University School of Medicine, Nagano-Ken, Japan.
Kitano
K
K
Kishi
E
E
Hara
K
K
Ishida
F
F
Saito
H
H
Ota
M
M
Furuta
S
S
D000058:Accidental Falls; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006406:Hematoma / Q000209:etiology / Q000628:therapy*; D006650:Histocompatibility Testing; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D065227:Transfusion Reaction