[Arrhythmias due to energy mosaic caused by gene mutations for energy transducing system in myocardium].
Recently, accumulation of oxygen damages and mutations in mitochondrial DNA during the life of an individual has been demonstrated to occur synergistically at a exponential rate. The mutations were caused by inherited germ line mutations and damage of mitochondrial DNA by active oxygen. Mitotic segregation of the mutated mitochondrial DNA causes energy mosaic among myofibire leading to arrhythmias. Two major mitochondrial DNA mutations, point mutations and deletion, detected by the total base sequencing among the patients were demonstrated and discussed.
Ozawa
T
T
Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya.
D001145:Arrhythmias, Cardiac / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D004734:Energy Metabolism; D017353:Gene Deletion; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism*; D009154:Mutation; D017354:Point Mutation
D004272:DNA, Mitochondrial