title: Adult onset polymyositis/dermatomyositis: clinical and laboratory features and treatment response in 75 patients.
abstract: OBJECTIVE
  To determine possible similarities and differences in clinical and laboratory features and treatment response between patients in Singapore with polymyositis (PM) and dermatomyositis (DM) and reported series.
  
  
  METHODS
  Case records of adult patients (16 years old and above) referred to the 3 main electromyographic (EMG) laboratories in Singapore between 1 June 1986 and 31 May 1991 were reviewed if the referring diagnosis was myositis or myopathy for investigation. A computer search for adult patients with a diagnosis of PM/DM (ICD codes 710.3, 710.4, 517.8) who attended the main rheumatology and neurology centre during this period was also carried out. The criteria for PM/DM proposed by Bohan and Peter was adopted.
  
  
  RESULTS
  The incidence of PM/DM was 7.7 cases per million population per year. There were 35 PM and 40 DM cases with a median age at diagnosis of 50.7 years (SD: 16.7) and significantly more females in the PM group (p < 0.05). At presentation, 86.7% had proximal myopathy, 34.7% had arthralgia/arthritis and 18.7% had cutaneous vasculitis. The creatine kinase level was elevated in 89.3% of patients and positive EMG and muscle biopsy in 79.4% and 76.4% respectively. Systemic lupus erythematosus was the commonest associated connective tissue disease. The percentage of patients with malignancy was higher in DM compared with PM (p < 0.01) and they were significantly older (mean age 61.8 years) (p < 0.001). Patients who achieved remission were significantly younger (mean age 46.4 years, p < 0.05). The overall mortality rate was 26.7% with infection and malignancy as the main causes of death.
  
  
  CONCLUSIONS
  The results of the study suggest ethnicity does not influence the expression of PM/DM in view of the considerable similarities in frequency and clinical expression of disease in the population studied compared with series from other countries.
authors.affiliation: Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
authors.forename: E T
authors.initials: ET
authors.lastname: Koh
authors.forename: A
authors.initials: A
authors.lastname: Seow
authors.forename: B
authors.initials: B
authors.lastname: Ong
authors.forename: P
authors.initials: P
authors.lastname: Ratnagopal
authors.forename: H
authors.initials: H
authors.lastname: Tjia
authors.forename: H H
authors.initials: HH
authors.lastname: Chng
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003882:Dermatomyositis / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000208:ethnology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology; D017285:Polymyositis / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000208:ethnology / Q000503:physiopathology; D012189:Retrospective Studies; D012737:Sex Factors; D012846:Singapore / Q000453:epidemiology