title: [Severity of myasthenia gravis is related to the degree of neuromuscular blocking effect by isoflurane].
abstract: We studied neuromuscular blocking effects of isoflurane using a neuromuscular transmission monitor in three myasthenia gravis patients. Severity of myasthenia gravis was different among three patients. T1 decreased by 12% in a mild case (I type), by 18% in a moderate case (IIa type) and by 42% in severe case (III type) during isoflurane anesthesia. Also, TOF ratio decreased by 12% in a mild case, by 22% in a moderate case, and 48% in a severe case during isoflurane anesthesia. We conclude that in patients with more severe myasthenia gravis, neuromuscular blocking effect of isoflurane is more potentiated.
authors.affiliation: Department of Anesthesiology, Akita University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Kadosaki
authors.forename: K
authors.initials: K
authors.lastname: Enzan
authors.forename: T
authors.initials: T
authors.lastname: Horiguchi
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D005260:Female; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*
chemical_list: D009466:Neuromuscular Blocking Agents; D007530:Isoflurane