Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events: a cohort study.
We performed a population-based study of over 100,000 users of diclofenac, naproxen, or piroxicam to identify cases of important blood, skin, central nervous system, kidney, pancreas, or pulmonary disorders caused by these drugs. In three cases a causal relation seemed likely; one of hemolytic anemia attributed to diclofenac, one of neutropenia attributed to naproxen, and one of pancreatitis attributed to piroxicam. In 13 additional cases a causal connection seemed unlikely but could not be fully ruled out. We conclude that such illnesses are uncommonly caused by the three agents studied.
Jick
H
H
Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, MA 02173-5207.
Derby
L E
LE
García Rodríguez
L A
LA
Jick
S S
SS
Dean
A D
AD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D015331:Cohort Studies; D004008:Diclofenac / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D009288:Naproxen / Q000009:adverse effects; D009503:Neutropenia / Q000139:chemically induced*; D010195:Pancreatitis / Q000139:chemically induced*; D010894:Piroxicam / Q000009:adverse effects; D013921:Thrombocytopenia / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D004008:Diclofenac; D009288:Naproxen