[Potential nephrotoxicity of 2nd generation cephalosporins: cefuroxime versus cefotiam].
Forty-one hospitalized patients were randomized to be treated with cefuroxime (4.05 g/die) or cefotiam (5.30 g/die). Several patients received additionally furosemide (0.5 mg/kg body weight) intravenously. Serum creatinine and creatinine clearance did not show significant differences during versus after treatment in any of the groups. Cefotiam or cefotiam/furosemide treated patients displayed higher proteinuria and higher urinary excretion of lysosomal enzymes (leucine aminopeptidase) than patients treated with cefuroxime or cefuroxime/furosemide. Our data indicate higher tubulotoxicity of cefotiam compared to cefuroxime.
Riegel
W
W
Medizinische Universitätsklinik IV, Homburg/Saar.
Hörl
W H
WH
D000328:Adult; D000368:Aged; D015310:Cefotiam / Q000009:adverse effects* / Q000627:therapeutic use; D002444:Cefuroxime / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007931:Leucyl Aminopeptidase / Q000652:urine; D008875:Middle Aged; D011446:Prospective Studies; D011507:Proteinuria / Q000139:chemically induced
D005665:Furosemide; D015310:Cefotiam; D007931:Leucyl Aminopeptidase; D002444:Cefuroxime
Potentielle Nephrotoxizität von Cephalosporinen der 2. Generation: Cefuroxim versus Cefotiam.