European collaborative study of antibiotic prophylaxis for transurethral resection of the prostate.
A prospective randomised trial was undertaken in nine European Hospitals to test antibiotic prophylaxis for men undergoing transurethral resection of the prostate. Of the men with no significant growth (< 10(4) cfu ml-1) in their preoperative urine, 247 received a single 1 gram dose of ceftazidime with the induction of anaesthesia, 256 received 1 g daily from the time of induction of anaesthesia until removal of the urethral catheter (but < or = 5 days) and 261 received no prophylaxis. Of evaluable patients 83 (33.9%), 45 (18.7%) and 29 (11.6%) of the no-prophylaxis, single-dose and multidose groups, respectively, developed urinary tract infection in the immediate post-operative period. There were significantly fewer febrile episodes and fewer prescriptions for alternative antibiotics in teh ceftazidime-treated groups. For men developed peri-operative septicaemia and all were in the no-prophylaxis group. We conclude that patients, even those with culture-negative urine pre-operatively, benefit from antibiotic prophylaxis and that antibiotic prophylaxis should be considered for all men undergoing prostatic surgery as a routine procedure.
Hargreave
T B
TB
University Department of Urology, Western General Hospital, Edinburgh, Scotland.
Botto
H
H
Rikken
G H
GH
Hindmarsh
J R
JR
McDermott
T E
TE
Mjolnerod
O K
OK
Petays
P
P
Schalkhäuser
K
K
Stellos
A
A
D000368:Aged; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control; D001437:Bacteriuria / Q000382:microbiology; D002442:Ceftazidime / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011446:Prospective Studies; D011468:Prostatectomy
D002442:Ceftazidime