[Ultrastructural and biochemical enzymatic properties of right ventricular muscles during hindlimb suspension in rats].
As a result of exposure to microgravitational forces, the body fluids are shifted from lower part of the body to upper part with a volume of about 2 liters. Many reports on the hemodynamic, humoral, and other biomedical aspects of the body exposed by weightlessness have been reported. A 45 degree head-down tail suspension was introduced to examine ultrastructure and biochemical analyses on the right and left ventricles in rats. Increases in oxydative enzyme activities and relatively increase in m-CK(mitochondrial creatine kinase) were recognized in the right ventricle after suspension for 2 weeks. Mitochondrial volume and density of mitochondrial cristae were also increased. Direct measurement of right ventricular systolic pressure of suspended rats were significantly higher (28.99 +/- 3.11 mmHg) than that of control rats (20.99 +/- 2.94 mmHg), (p < 0.01).
Kunishima
T
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Department of Physiology, St. Marianna University School of Medicine, Kanagawa, Japan.
D000818:Animals; D001835:Body Weight; D003402:Creatine Kinase / Q000378:metabolism; D006352:Heart Ventricles / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008954:Models, Biological; D009206:Myocardium / Q000201:enzymology* / Q000648:ultrastructure*; D009929:Organ Size; D010732:Phosphofructokinase-1 / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014893:Weightlessness / Q000009:adverse effects*
D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D010732:Phosphofructokinase-1; D003402:Creatine Kinase