Tuftsin-bearing liposomes as drug vehicles in the treatment of experimental aspergillosis.
Encapsulation of amphotericin B in tuftsin-bearing liposomes greatly increased its efficacy in treatment of human aspergillosis in mice. Also, the drug efficacy was significantly increased by pretreating the animals with drug-free tuftsin-bearing liposomes. These results demonstrate that macrophage activation can considerably enhance the therapeutic efficacy of antifungal drugs, like amphotericin B.
Owais
M
M
Institute of Microbial Technology, Chandigarh, India.
Ahmed
I
I
Krishnakumar
B
B
Jain
R K
RK
Bachhawat
B K
BK
Gupta
C M
CM
D000595:Amino Acid Sequence; D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D014405:Tuftsin / Q000008:administration & dosage* / Q000627:therapeutic use
D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B; D014405:Tuftsin