title: HIV-2 infection in Bissau, West Africa, 1987-1989: incidence, prevalences, and routes of transmission.
abstract: In a community study, the HIV-1 and HIV-2 antibody status of the inhabitants of 100 randomly chosen houses in Bissau, West Africa, were followed from 1987 to 1989. There was no HIV-1 infection alone, while the HIV-2 seroprevalence in adults was 8.9% (58 of 652) in 1987 and 10.1% (61 of 603) in 1989. HIV-2 seroprevalence in 15- to 39-year-olds was 6.1% in 1987 and 11.3% in newcomers in 1989 [the Mantel-Haentzel weighted relative risk (RRMH) = 1.86; 95% confidence interval (CI): 1.07-3.24]. Three hundred thirty adults who were HIV-2 seronegative in 1987 were reexamined in 1989; seven had seroconverted. Follow-up time was 700 person years, giving an incidence of HIV-2 infection of 1 per 100 person years. With a history of sexually transmitted disease (STD), the RR of seroconverting was 9.95 (2.31-42.80). Blood transfusions received since 1987 did not result in seroconversions. No case of vertical transmission of HIV-2 was seen. There was an excess mortality in those who were HIV-2 seropositive; however, it was statistically significant only for children (RR = 22.27; 95% CI: 6.92-71.70; p < 0.0001), not for adults (RR = 2.16; 95% CI: 0.81-5.76; p = 0.23), when considering death from disease only.
authors.affiliation: Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: A G
authors.initials: AG
authors.lastname: Poulsen
authors.forename: P
authors.initials: P
authors.lastname: Aaby
authors.forename: A
authors.initials: A
authors.lastname: Gottschau
authors.forename: B B
authors.initials: BB
authors.lastname: Kvinesdal
authors.forename: F
authors.initials: F
authors.lastname: Dias
authors.forename: K
authors.initials: K
authors.lastname: Mølbak
authors.forename: E
authors.initials: E
authors.lastname: Lauritzen
mesh_terms: D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006169:Guinea-Bissau / Q000453:epidemiology; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000401:mortality / Q000635:transmission; D015528:HIV Seroprevalence; D015498:HIV-2 / Q000276:immunology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012749:Sexually Transmitted Diseases / Q000150:complications
chemical_list: D015483:HIV Antibodies