title: The power of systematic genealogical study in familial Alzheimer disease.
abstract: Several kindreds (N, C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.
authors.affiliation: USSL 17, Lamezia Terme.
authors.forename: A C
authors.initials: AC
authors.lastname: Bruni
authors.forename: M P
authors.initials: MP
authors.lastname: Montesi
authors.forename: I
authors.initials: I
authors.lastname: Rainero
authors.forename: L
authors.initials: L
authors.lastname: Ferini-Strambi
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: L
authors.initials: L
authors.lastname: Pinessi
authors.forename: G
authors.initials: G
authors.lastname: Gei
authors.forename: D
authors.initials: D
authors.lastname: Fragiacomo
authors.forename: L
authors.initials: L
authors.lastname: Bergamini
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree