[The effect of hematoporphyrin derivative on the postradiation recovery of hemopoiesis in mice].
In experiments with mice exposed to gamma quanta (6.0 Gy) it was shown that a single injection of disodium salt of 2,4-di(alpha-methoxyethyl)deuteroporphyrin IX (50 and 12 mg/kg) both 15 min before and 15 min after irradiation promoted postirradiation regeneration of all bone marrow haemopoiesis compartments. The agent produced a more pronounced stimulatory effect when administered after irradiation.
Deshevoĭ
Iu B
IuB
Moroz
B B
BB
Bezin
G I
GI
Kovtun
V Iu
VIu
Ponomarev
G V
GV
Kirillova
G V
GV
D000818:Animals; D002588:Cesium Radioisotopes; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D017324:Hematoporphyrin Derivative / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors
D002588:Cesium Radioisotopes; D017324:Hematoporphyrin Derivative
Vliianie proizvodnogo gematoporfirina na postradiatsionnoe vosstanovlenie krovetvoreniia u mysheĭ.