title: Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women.
abstract: Bone mineral density (BMD) and risk factors for osteoporosis were assessed in 348 apparently healthy women over 70 years of age (mean 82.3 years). BMD was measured at both hips and the dominant distal radius. With stepwise multiple regression the best determinants of BMD, selected from anthropometric measurements, age, and years since menopause, were body weight and years since menopause (R2 between 0.07 and 0.20, p < 0.001). Risk and protective factors for osteoporosis were analyzed as indicator variables by multiple regression and corrected for confounding by age, years since menopause, and body weight. Significantly lower BMD at the hip was found in participants with impaired mobility (-5%) and users of loop diuretics (-5%). Use of thiazide(like) diuretics did not influence BMD significantly at any site. Users of oral corticosteroids had a significantly lower BMD at the hip and the distal radius (range -9.1 to -24.3%). Participants with a history of Colles' fracture (n = 56) had a significantly lower BMD at the other radius (-12.9%). The mean calcium intake from dairy products was high (mean 921 mg/day), only 11% having an intake below 500 mg. A relation of calcium intake with BMD could not be detected at any measurement site. We conclude that BMD cannot be adequately predicted in elderly women. Risk factors for low BMD in the elderly are low body weight, high number of years since menopause, impaired mobility, and use of loop diuretics and oral corticosteroids. Calcium intake was not a risk factor in this study, but the number of individuals on a low calcium intake was small.
authors.affiliation: Institute for Research in Extramural Medicine (EMGO-Institute), Vrije Universiteit, Amsterdam.
authors.forename: M E
authors.initials: ME
authors.lastname: Ooms
authors.forename: P
authors.initials: P
authors.lastname: Lips
authors.forename: A
authors.initials: A
authors.lastname: Van Lingen
authors.forename: H A
authors.initials: HA
authors.lastname: Valkenburg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D005269:Femur / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008593:Menopause; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012307:Risk Factors