Toward a novel metal-based chemotherapy against tropical diseases. 1. Enhancement of the efficacy of clotrimazole against Trypanosoma cruzi by complexation to ruthenium in RuCl2(clotrimazole)2.
Sánchez-Delgado
R A
RA
Biological Chemistry Laboratories, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas.
Lazardi
K
K
Rincón
L
L
Urbina
J A
JA
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D003022:Clotrimazole / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D012428:Ruthenium / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000138:chemical synthesis*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D014344:Trypanocidal Agents; D012428:Ruthenium; D003022:Clotrimazole