title: Brucellosis: imported and laboratory-acquired cases, and an overview of treatment trials.
abstract: Following the successful eradication of Brucella abortus infection in cattle, human brucellosis in England and Wales has become an uncommon imported disease. Culture of the organism presents a major laboratory hazard, and difficulties in identification may occur using a biochemical test-strip method. An overview of recent treatment trials of brucellosis indicates that regimens combining streptomycin and doxycycline are associated with a higher success rate (judged by the frequency of treatment failure and relapse following therapy) than combinations of rifampicin and doxycycline.
authors.affiliation: University of Oxford, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK.
authors.forename: G A
authors.initials: GA
authors.lastname: Luzzi
authors.forename: R
authors.initials: R
authors.lastname: Brindle
authors.forename: P N
authors.initials: PN
authors.lastname: Sockett
authors.forename: J
authors.initials: J
authors.lastname: Solera
authors.forename: P
authors.initials: P
authors.lastname: Klenerman
authors.forename: D A
authors.initials: DA
authors.lastname: Warrell
mesh_terms: D000293:Adolescent; D000328:Adult; D002006:Brucellosis / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission*; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007757:Laboratory Infection / Q000209:etiology*; D008297:Male; D014195:Travel; D014852:Wales / Q000453:epidemiology