In vitro tests of neurotoxicity.
This review presents some of the newer techniques in the rapidly advancing area of neurotoxicity testing in vitro. They are not described at length, and more details can be obtained from the cited references. In vitro testing offers the possibility of relatively inexpensive screening of large numbers of pharmaceutical compounds, formulations, and environmental substances. The level of sophistication attained in this field may soon allow much more accurate safety limits to be set, as specific mechanisms of neurotoxicity are elucidated.
Abdulla
E M
EM
Department of Neuroscience, Institute of Psychiatry, London, England, U.K.
Campbell
I C
IC
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D046508:Culture Techniques / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D004594:Electrophysiology; D016501:Neurites / Q000187:drug effects; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D014116:Toxicology / Q000379:methods*