Electrophysiological changes accompanying DSP-4 lesions of rat locus coeruleus neurons.
The electrophysiological characteristics of intracellularly recorded locus coeruleus (LC) neurons in brain stem slices from DSP-4 treated animals have been compared to those from untreated controls. LC neurons from DSP-4 treated animals had action potentials and Ca2+ spikes (elicited in the presence of TTX) of significantly reduced duration compared to controls. These observations suggest that chemical axotomy with DSP-4 reduces Ca2+ conductance in neurons of the locus coeruleus.
Magnuson
D S
DS
Department of Physiology, University of Ottawa, Ont., Canada.
Staines
W A
WA
Marshall
K C
KC
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000502:physiology; D001596:Benzylamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008125:Locus Coeruleus / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology*; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D013779:Tetrodotoxin / Q000494:pharmacology
D001596:Benzylamines; D009498:Neurotoxins; D014179:Neurotransmitter Uptake Inhibitors; D013779:Tetrodotoxin; C012102:DSP 4