[Exposure to DMTP by sprayers and the urinary excretion of metabolites].
Exposure in vinyl hothouses to DMTP (0,0-dimethyl-s-(2-methoxy-1,3,4-thiadiazol-5(4H)-onyl-(4)-m ethyl)- dithiophosphate) was studied in 5 spray-operators and one assistant worker. To determine the level of exposure to DMTP, concentrations in the atmosphere, concentration in atmosphere near the operators breathing zone, skin levels from penetration through the operator's clothing, and urinary excretion of metabolites of DMTP (2,3-dihydro-5-methoxy-3-methyl-sulphonyl methyl-1,3,4-thiadiazol-2-one and 2,3-dihydro-5-methoxy-3-methyl-sulphinyl methyl-1,3,4-thiadiazol-2-one) were measured. The results were as follows; 1. DMTP concentrations in the atmosphere were 10.0-18.0 micrograms/m3, and concentrations in the atmosphere near the operators breathing zone were 5.4-33.6 micrograms/m3 during spraying. 2. Metabolites of DMTP were detected in all sprayers. Levels were 1.5 to 31.6 micrograms/day for the sulphonyl-metabolite. But it was not detected in the assistant sprayer. 3. Urinary concentrations of the DMTP metabolite were maximum 15-20 h after spraying. 4. Amount of DMTP adherent on the skin was estimated to be 0.4 to 71.3 micrograms for spray-operators. Variations resulted from differences in condition of protective clothing. 5. DMTP appeared to be absorbed not only through the respiratory system, but also through the skin.
Ueda
T
T
Department of Public Health, Kansai Medical University.
Kosaka
M
M
Yoshida
M
M
Nakazono
N
N
Hara
I
I
D005260:Female; D006801:Humans; D007306:Insecticides / Q000493:pharmacokinetics / Q000652:urine*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D009946:Organothiophosphorus Compounds / Q000493:pharmacokinetics / Q000652:urine*; D012137:Respiratory System / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
D007306:Insecticides; D009946:Organothiophosphorus Compounds; C005828:methidathion