Influence of ventral tegmental area (A10 region) on flight behaviour elicited by hypothalamic stimulation in the cat.
The influence of the ventral tegmental area (VTA) (dopaminergic A10 group neurons) on flight behaviour, induced by hypothalamic stimulation, was studied in the cat. Co-stimulation of hypothalamus and VTA (ipsi- or contralateral) induced an increase of the flight latency. Slow-motion analysis of flight behaviour showed that this increase was due to the augmentation of the fixation latency (FL) whereas the upright latency (UL) was not modified. Sulpiride injection (50 mg/kg i.p.) provoked the disappearance of VTA effect without affecting the basal behavioural sequence. The results show that DA A10 group neurons increase the attentive component of the flight reaction, suggesting a possible influence of the DA A10 system on the mechanisms modulating focused attention in the animal.
Crescimanno
G
G
Institute of Human Physiology, University of Palermo, Italy.
Ferdico
M
M
Emmi
A
A
Sorbera
F
F
D'Amelio
M
M
Amato
G
G
D000758:Anesthesia; D000818:Animals; D001288:Attention / Q000187:drug effects; D002415:Cats; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D004924:Escape Reaction / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D013469:Sulpiride / Q000494:pharmacology; D013681:Tegmentum Mesencephali / Q000502:physiology*
D013469:Sulpiride; D004298:Dopamine