title: Positron emission tomography diagnosis of pulmonary metastases in osteogenic sarcoma.
abstract: Positron emission tomography (PET) is an imaging technique that can produce high-quality tomographic images reflective of the metabolic characteristics of imaged tissue. Among the many positron-emitting tracers utilized in conjunction with PET is [18F]fluoride ion; it is actively taken up in bone in proportion to bone metabolic activity, analogous to standard nuclear medicine bone scanning agents such as technetium methylenediphosphonate ([99mTc]MDP). Whole-body imaging with PET and [18F]fluoride ion generates tomographic images that are useful in mapping patterns of bone metabolism, as well as identifying extraosseous site of bone formation or calcification. We report the case of a patient with polyostotic fibrous dysplasia, metastatic osteogenic sarcoma, and a breast mass, who presented with pulmonary nodules, in whom [18F] fluoride ion/PET imaging was useful in confirming the nature of the pulmonary nodules.
authors.affiliation: Division of Hematology-Oncology, UCLA School of Medicine 90024.
authors.forename: N
authors.initials: N
authors.lastname: Tse
authors.forename: C
authors.initials: C
authors.lastname: Hoh
authors.forename: R
authors.initials: R
authors.lastname: Hawkins
authors.forename: M
authors.initials: M
authors.lastname: Phelps
authors.forename: J
authors.initials: J
authors.lastname: Glaspy
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications; D005462:Fluorine Radioisotopes; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D012516:Osteosarcoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000556:secondary; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes