Sequential imputation and multipoint linkage analysis.
A novel Monte Carlo method for linkage analyses involving large pedigrees and many polymorphic loci is introduced. Issues related to the efficiency of the method are discussed.
Kong
A
A
Department of Statistics, University of Chicago, IL 60637.
Cox
N
N
Frigge
M
M
Irwin
M
M
D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D009010:Monte Carlo Method; D010375:Pedigree
D005819:Genetic Markers