title: A case of necrobiosis lipoidica treated with systemic corticosteroid.
abstract: A 43-year-old woman had asymptomatic eruptions on the anterior sides of both legs for 5 years. Biopsy specimens revealed the typical findings of necrobiosis lipoidica. An immunofluorescence study demonstrated no deposits of immunoglobulins, complement, or fibrinogen in vessel walls. Immunohistochemical staining revealed CD4 positive lymphocytes dominating in the lesion and strong expression of ICAM-1 on the endothelial cells, giant cells, lymphocytes and dermal fibroblasts in the lesion. The eruptions resolved remarkably with oral corticosteroid therapy.
authors.affiliation: Department of Dermatology, Mie University School of Medicine, Tsu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D009335:Necrobiosis Lipoidica / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D010248:Paramethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D003176:Complement C3; D007136:Immunoglobulins; C032128:paramethasone acetate; D010248:Paramethasone