title: Immunodeficiency with increased immunoglobulin M associated with growth hormone insufficiency.
abstract: Growth hormone deficiency associated with hypogammaglobulinemia has been reported only in a few publications. Our patient was a male with recurrent episodes of infections. Serum immunoglobulin (Ig) G was extremely low although IgM concentration was much greater than the normal limit. Growth hormone responses to insulin, 1-Dopa and growth hormone-releasing hormone were low. The mean growth hormone concentration during sleep was less than the normal limit. These results are consistent with hyper-IgM immunodeficiency associated with growth hormone deficiency. The mode of transmission appears to be autosomal dominant. This combination has not been reported previously.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Tottori University, Yonaga, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohzeki
authors.forename: K
authors.initials: K
authors.lastname: Hanaki
authors.forename: H
authors.initials: H
authors.lastname: Motozumi
authors.forename: H
authors.initials: H
authors.lastname: Ohtahara
authors.forename: H
authors.initials: H
authors.lastname: Hayashibara
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Shiraki
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuji
authors.forename: H
authors.initials: H
authors.lastname: Emura
mesh_terms: D000293:Adolescent; D006130:Growth Disorders / Q000150:complications / Q000235:genetics / Q000276:immunology*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D010375:Pedigree
chemical_list: D007075:Immunoglobulin M; D013006:Growth Hormone