Perfluorocarbon effects on rabbit blood-retinal barrier permeability.
Studies have been made of the effects of intravitreal perfluoro-n-octane on the permeability to fluorescein of the blood-retinal barrier in rabbits. At day 1 after injection, there is increased aqueous humor fluorescence that reflects the physical disturbance to the eye following injection. From that time through 7 weeks, there is no evidence of any overt toxicity to the blood-retinal barrier. The retention in the vitreous of a small volume of perfluoro-n-octane following its intraoperative use would not be expected to induce a toxic response. Some effect on an already compromised retina cannot, however, be excluded.
Green
K
K
Department of Ophthalmology Medical College of Georgia, Augusta 30912-3400.
Slagle
T
T
Chaknis
M J
MJ
Cheeks
L
L
Chang
S
S
D000818:Animals; D001692:Biological Transport; D001813:Blood-Retinal Barrier; D002463:Cell Membrane Permeability; D019793:Fluorescein; D005452:Fluoresceins / Q000493:pharmacokinetics; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D015590:Fluorophotometry; D011817:Rabbits; D014822:Vitreous Body
D005452:Fluoresceins; D005466:Fluorocarbons; C073608:perfluorooctane; D019793:Fluorescein