Preference and aversion for deterrent chemicals in two species of Peromyscus mouse.
Deterrent chemicals such as quinine hydrochloride (QHC1) are generally considered to be aversive to mammals at all detectable concentrations. However, several species contain individuals that drink solutions containing low concentrations of deterrents in preference to plain water. The present study examines this paradoxical preference in two species of mouse, Peromyscus melanotis and P. aztecus. Preliminary findings had suggested that whereas some P. aztecus prefer low concentrations of QHC1, no P. melanotis prefer any concentration of QHC1. Experiment 1 tested the hypothesis that individual mice that prefer low concentrations of QHC1 would respond similarly to four other deterrents described by humans as bitter and/or astringent (ouabain, hop extract, sucrose octaacetate, and tannic acid) in 48-h, two-bottle choice tests. Peromyscus aztecus displayed a large amount of intraspecific variation in response to all five deterrents. Those P. aztecus that drank low concentrations of QHC1 in preference to plain water were significantly more likely to respond similarly to low concentrations of the other deterrents. No P. melanotis displayed a preference for any concentration of either deterrent. Experiment 2 examined the temporal stability of the response to 0.1 mM QHC1 in P. aztecus over six consecutive choice tests. Mice were divided into three groups based on their initial response to the QHC1 solution (preference, no response, or rejection) and then subjected to the 12-day test. The response of mice within each of the groups did not change significantly over time.(ABSTRACT TRUNCATED AT 250 WORDS)
Glendinning
J I
JI
Department of Biological Science, Florida State University, Tallahassee 32306.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005421:Flavoring Agents / Q000494:pharmacology*; D005518:Food Preferences / Q000187:drug effects*; D047348:Hydrolyzable Tannins / Q000494:pharmacology; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D010542:Peromyscus; D010936:Plant Extracts / Q000494:pharmacology*; D011803:Quinine / Q000494:pharmacology; D012931:Social Environment; D013045:Species Specificity; D013395:Sucrose / Q000031:analogs & derivatives / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
D005421:Flavoring Agents; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; C026879:sucrose octaacetate; D013395:Sucrose; D010042:Ouabain; D011803:Quinine