2-Hydroxyhexadecanoic and 8,9,13-trihydroxydocosanoic acid accumulation by yeasts treated with fumonisin B1.
Fumonisin B1 is a sphingolipid-like compound that enhances the accumulation of yeast sphingolipids and 2-hydroxy fatty acids. These lipids occur both as freely extractable and cell bound components in yeast fermentations. Both free and bound 2-hydroxy fatty acids produced by Pichia sydowiorum NRRL Y-7130 were increased when fumonisin B1 (50 mg/L) was added to the usual growth medium containing yeast extract/malt extract/peptone/glucose. Fumonisin-treated cultures contained 38 mg/L more 2-hydroxyhexadecanoic and 15 mg/L more 2-hydroxyoctadecanoic acids than did untreated cultures. By contrast, fumonisin inhibited the accumulation of free 8,9,13-trihydroxydocosanoic acid in Rhodotorula sp. YB-2501 cultures, leading to 240 mg/L lower trihydroxy acid production than by untreated cultures.
Kaneshiro
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Agricultural Research Service, U.S. Department of Agriculture, Peoria, Illinois 61604.
Vesonder
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RF
Peterson
R E
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Bagby
M O
MO
D002274:Carcinogens, Environmental / Q000378:metabolism; D002855:Chromatography, Thin Layer; D037341:Fumonisins; D006880:Hydroxy Acids / Q000378:metabolism*; D009183:Mycotoxins / Q000494:pharmacology*; D010169:Palmitic Acids / Q000378:metabolism*; D010843:Pichia / Q000187:drug effects / Q000378:metabolism*; D012248:Rhodotorula / Q000187:drug effects / Q000378:metabolism*
D002274:Carcinogens, Environmental; D037341:Fumonisins; D006880:Hydroxy Acids; D009183:Mycotoxins; D010169:Palmitic Acids; C081820:8,9,13-trihydroxydocosanoic acid; C056933:fumonisin B1; C024707:2-hydroxyhexadecanoic acid