In vitro methods for assessing human hepatic drug metabolism: their use in drug development.
Wrighton
S A
SA
Department of Drug Metabolism, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Vandenbranden
M
M
Stevens
J C
JC
Shipley
L A
LA
Ring
B J
BJ
Rettie
A E
AE
Cashman
J R
JR
D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D010105:Oxygenases / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming)