[The antidepressive properties of anaprilin].
After chronic administration of propranolol (1 and 5 mg/kg) to rats for 14 days, the time course of forced swimming was changed, by decreasing the rhythmic index of depression. With propranolol, the depressogenic properties of reserpine and clonidine were attenuated. The antidepressive activity of propranolol was associated with cerebral beta-adrenoceptor block.
Arushanian
E B
EB
Beĭer
E V
EV
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003000:Clonidine; D003863:Depression / Q000188:drug therapy / Q000209:etiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D012110:Reserpine; D013550:Swimming; D013997:Time Factors
D000928:Antidepressive Agents; D012110:Reserpine; D011433:Propranolol; D003000:Clonidine
Antidepressivnye svoĭstva anaprilina.