Effect of food on pravastatin pharmacokinetics and pharmacodynamics.
The pharmacokinetics and pharmacodynamics of pravastatin 20 mg administered twice daily when taken with or one hour before meals were evaluated in 24 hypercholesterolemic men in an 8-week, open-label, randomized, two-way crossover study. The bioavailability of pravastatin was reduced significantly (p < or = 0.001) when it was taken with meals (AUC dropped 31% and Cmax dropped 49%), and mean Tmax increased 50% (p < or = 0.01). The mean elimination t1/2 was unaffected by taking pravastatin with food. However, reductions in mean total cholesterol and low density lipoprotein cholesterol were identical whether pravastatin was given with or before meals. In both treatment groups, total cholesterol and low-density lipoprotein cholesterol were significantly reduced from baseline (p < 0.001). These results indicate that although the bioavailability of pravastatin is reduced when taken with meals, the lipid-lowering efficacy of pravastatin is not altered. It can be concluded that pravastatin can be ingested without regard to meal time.
Pan
H Y
HY
Genentech, South San Francisco.
DeVault
A R
AR
Brescia
D
D
Willard
D A
DA
McGovern
M E
ME
Whigan
D B
DB
Ivashkiv
E
E
D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005502:Food; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000493:pharmacokinetics* / Q000494:pharmacology*; D013997:Time Factors
D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol; D017035:Pravastatin