Immunizing potential of ultraviolet-attenuated cercariae of Schistosoma mansoni in rodent hosts.
Schistosoma mansoni cercariae attenuated with ultraviolet (UV) irradiation (254 nm) at a dose of 18 mJ/cm2 induced partial resistance against a homologous challenge in male ICR mice and male Hartley guinea pigs. The reduction in the adult worm burden was 51% and 37% +/- 13%, respectively. On the other hand, male and female Mongolian gerbils (Meriones unguiculatus) vaccinated with UV-attenuated cercariae exhibited marginal resistance (13% +/- 9% and 22% +/- 10%, respectively). This raises the possibility that gerbils might have an unknown immune-characteristic nature. The usefulness of UV-attenuated cercariae is discussed with respect to the control of the disease.
Kamiya
H
H
Department of Parasitology, Hirosaki University School of Medicine, Japan.
Ozaki
T
T
Nakayama
H
H
Inaba
T
T
D000818:Animals; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005260:Female; D005849:Gerbillinae; D006168:Guinea Pigs; D007114:Immunization; D007814:Larva / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012377:Rodentia / Q000276:immunology / Q000469:parasitology; D012550:Schistosoma mansoni / Q000276:immunology* / Q000528:radiation effects*; D012555:Schistosomiasis mansoni / Q000276:immunology*; D014466:Ultraviolet Rays; D014613:Vaccines, Attenuated / Q000276:immunology*
D014613:Vaccines, Attenuated