Binding of nuclear proteins to transcription regulatory elements in selenium deficiency.
Dietary selenium deficiency in rats increased binding of liver nuclear proteins to DNA regulatory sequences which activate transcription in response to oxidative stress. In contrast, binding to the activator protein-1 control sequence, which is inhibited by oxidation, was decreased in selenium deficiency.
Christensen
M J
MJ
Department of Food Science and Nutrition, Brigham Young University, Provo, UT 84602.
Pusey
N W
NW
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005809:Genes, Regulator; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D011485:Protein Binding; D011506:Proteins; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*
D000975:Antioxidants; D009687:Nuclear Proteins; D011506:Proteins; D016755:Proto-Oncogene Proteins c-jun; D015534:Trans-Activators; D004247:DNA; D005979:Glutathione Peroxidase; D012643:Selenium