title: [Are there prognostic parameters for predicting the success of regional chemotherapy in nonresectable liver metastases of colorectal cancer?].
abstract: When compared with systemic therapy, hepatic arterial chemotherapy significantly increases the response rate for hepatic metastases from colorectal carcinomas. However, only 2 studies showed a significant prolongation of survival. In our study on 54 patients tumor related characteristics and the response to regional chemotherapy were correlated to the success of the treatment. In a linear discriminant analysis the response to regional chemotherapy was the main prognostic factor for the 1-year survival, rate, followed by positive lymph nodes in the Lig. hepatoduodenale. The other pretherapeutic factors such as liver involvement and CEA rate were of less importance.
authors.affiliation: Chirurgische Klinik und Poliklinik, Klinikum Steglitz der Freien Universität Berlin.
authors.forename: J
authors.initials: J
authors.lastname: Boese-Landgraf
authors.forename: R
authors.initials: R
authors.lastname: Häring
authors.forename: G
authors.initials: G
authors.lastname: Berger
authors.forename: B
authors.initials: B
authors.lastname: Weber
authors.forename: W
authors.initials: W
authors.lastname: Hopfenmüller
authors.forename: K
authors.initials: K
authors.lastname: Hager
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D005472:Fluorouracil
vernacular_title: Gibt es prognostische Parameter, die den Erfolg einer regionalen Chemotherapie bei nichtresektablen Lebermetastasen kolorektaler Karzinome vorhersagen?