Scleroderma and the carcinoid syndrome.
The follow up of a case of the carcinoid syndrome complicated by scleroderma is reported, in which progress of the disease may have been halted by treatment with a combination of cyproheptadine, parachlorophenylalanine and prednisolone. Impairment of tryptophan and 5-hydroxytryptamine (serotonin) metabolism appears central to the development of skin fibrosis in the carcinoid syndrome and may be indicative of important mechanisms in the pathogenesis of idiopathic scleroderma.
Ratnavel
R C
RC
Department of Dermatology, Addenbrooke's Hosital, Cambridge, UK.
Burrows
N P
NP
Pye
R J
RJ
D000328:Adult; D001132:Arm; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000209:etiology / Q000473:pathology; D008303:Malignant Carcinoid Syndrome / Q000150:complications* / Q000473:pathology; D012598:Sclerosis; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology