title: Evaluation of the analgesic effect of metoclopramide after opioid-free analgesia.
abstract: Metoclopramide may enhance opioid analgesia, but it is not known if the drug is analgesic itself. This question was examined in a double-blind, randomized study of 38 patients undergoing knee arthroscopy with opioid-free anaesthesia comprising propofol, isoflurane and nitrous oxide in oxygen. At the end of surgery, patients received either metoclopramide 0.5 mg kg-1 or placebo i.v. After operation, they received patient-controlled analgesia with pethidine for 3 h, during which period, pain score was assessed on a visual analogue scale (VAS). There were no significant differences between the groups in the patterns of pethidine consumption. However, the VAS-pain scores tended to be smaller in the metoclopramide group; this difference was significant 30 min after operation. These results do not demonstrate conclusively a clinically relevant analgesic action of metoclopramide.
authors.affiliation: Department of Anaesthesiology, Linköping University Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Lisander
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled; D000700:Analgesics / Q000494:pharmacology*; D000768:Anesthesia, General; D001182:Arthroscopy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D008614:Meperidine / Q000008:administration & dosage; D008787:Metoclopramide / Q000494:pharmacology* / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000700:Analgesics; D008614:Meperidine; D008787:Metoclopramide