title: Activity on the central nervous system of Himanthalia elongata.
abstract: We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused very significant reductions in spontaneous locomotor activity, hypermotility, and rectal temperature. It postponed pentylenetetrazole-induced death and a slight increase of sleeping time was noted in the sodium pentobarbital-induced sleep test . A significant effect was only noted on motor coordination at high doses. F1 showed significant analgesic effects on the hot-plate test at all of the assayed doses but not on the writhing test, where only the highest dose showed significant activity.
authors.affiliation: Departamento de Farmacologia, Farmacia y Tecnología Farmacéutica, Universidad de Santiago, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Anca
authors.forename: M
authors.initials: M
authors.lastname: Lamela
authors.forename: J M
authors.initials: JM
authors.lastname: Calleja
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D008297:Male; D051379:Mice; D000459:Phaeophyceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D010936:Plant Extracts