Effect of antigen-specific immunoadsorption on antibody kinetics in a rat model.
The investigation of antibody kinetics following antigen-specific immunoadsorption in alkaline phosphatase immunized rats revealed significantly lower antibody levels than in untreated controls over a follow-up period of 6 weeks. A rebounding antibody synthesis as a result of specific depletion was not observed. Non-adsorption of specific antiidiotypic antibodies may explain these findings.
Zeuner
R A
RA
2nd Medical Clinic, Univ. of Kiel, FRG.
Béress
R
R
Schroeder
J O
JO
Euler
H H
HH
D000469:Alkaline Phosphatase / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000302:isolation & purification* / Q000378:metabolism; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology*; D003488:Cyanogen Bromide / Q000737:chemistry; D005260:Female; D007114:Immunization; D007163:Immunosorbent Techniques; D008954:Models, Biological; D051381:Rats; D017207:Rats, Sprague-Dawley; D012685:Sepharose / Q000737:chemistry
D000906:Antibodies; D000941:Antigens; D012685:Sepharose; D000469:Alkaline Phosphatase; D003488:Cyanogen Bromide