Immunopotentiation of synthetic oligopeptides by chemical conjugation to iscoms.
A method has been devised for coupling cysteine-containing peptides to pre-formed immune stimulating complexes (iscoms). Four different peptides were used and the peptide-iscom conjugates were evaluated as immunogens in mice. It was demonstrated that highly immunogenic peptide-iscom conjugates can be prepared provided that the peptides are successfully linked to the carrier iscoms.
Larsson
M
M
National Veterinary Institute, Department of Virology, Uppsala, Sweden.
Lövgren
K
K
Morein
B
B
D000276:Adjuvants, Immunologic; D000818:Animals; D002213:Capsid / Q000737:chemistry; D036022:Capsid Proteins; D002352:Carrier Proteins; D006063:Chorionic Gonadotropin / Q000737:chemistry; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000737:chemistry; D016882:ISCOMs / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D009842:Oligopeptides / Q000737:chemistry*; D015800:Protozoan Proteins / Q000737:chemistry
D000276:Adjuvants, Immunologic; D036022:Capsid Proteins; D002352:Carrier Proteins; D006063:Chorionic Gonadotropin; D016882:ISCOMs; D009842:Oligopeptides; D015800:Protozoan Proteins; D007987:Gonadotropin-Releasing Hormone