Detecting heterogeneity with the affected-pedigree-member (APM) method.
We have developed a novel test of heterogeneity based on the APM method. We present tests of this method on both empiric and simulated data.
Matise
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Department of Human Genetics, University of Pittsburgh, PA 15261.
Weeks
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D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001900:Boston / Q000453:epidemiology; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D010375:Pedigree; D013223:Statistics as Topic / Q000379:methods
D005819:Genetic Markers