Bayesian inference in multipoint gene mapping.
The problem of ordering and mapping genes on the basis of recombinant data and radiation hybrid data is formulated as a problem of Bayesian inference for an unknown permutation. The challenging computational problems posed by this approach are shown to be resolvable using Markov chain Monte Carlo methods.
Stephens
D A
DA
Department of Mathematics, Imperial College, London, UK.
Smith
A F
AF
D000465:Algorithms; D001499:Bayes Theorem; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008390:Markov Chains; D008957:Models, Genetic; D009010:Monte Carlo Method; D011995:Recombination, Genetic