Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle.
The complete amino acid sequence of an invertebrate calcium channel alpha 1-subunit from housefly (Musca domestica) larvae (designated Mdl alpha 1) has been deduced by cDNA cloning and sequence analysis. Mdl alpha 1 shares higher percent sequence identity with 1,4-dihydropyridine (DHP)-sensitive L-type than with DHP-insensitive calcium channels. As shown by whole mount in situ hybridization and immunostaining Mdl alpha 1 is predominantly expressed in the larval body wall musculature.
Grabner
M
M
Institut für Biochemische Pharmakologie, Universität Innsbruck, Austria.
Bachmann
A
A
Rosenthal
F
F
Striessnig
J
J
Schultz
C
C
Tautz
D
D
Glossmann
H
H
D000595:Amino Acid Sequence; D000818:Animals; D015220:Calcium Channels / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D004095:Dihydropyridines / Q000494:pharmacology; D015870:Gene Expression; D006793:Houseflies / Q000737:chemistry* / Q000235:genetics; D017403:In Situ Hybridization; D007814:Larva / Q000378:metabolism; D008969:Molecular Sequence Data; D009132:Muscles / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D017421:Sequence Analysis; D017385:Sequence Homology; D014018:Tissue Distribution
D015220:Calcium Channels; D018076:DNA, Complementary; D004095:Dihydropyridines; D012333:RNA, Messenger; C038806:1,4-dihydropyridine