[The adaptive response of B cells in culture to the action of cytotoxic agents. I. The stimulation of immunoglobulin synthesis and secretion by myeloma cells, hybridomas and human lymphocytes under the influence of adriamycin and ethidium bromide].
Effects of cytotoxic drugs, doxorubicin (adriamycin) and ethidium bromide, on immunoglobulin production have been studied in B-cell hybridomas, myelomas and human lymphocytes. Doxorubicin, and in a lesser extent ethidium bromide, are shown to enhance immunoglobulin production both in drug-resistant and drug-sensitive cell lines. Enhancement of immunoglobulin production is accompanied with that of the number of antibody forming cells and with immunoglobulin synthesis in these cells.
Davtian
T K
TK
Meliksetian
M B
MB
Ignatova
T N
TN
Aleksanian
Iu T
IuT
D000222:Adaptation, Physiological / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D004317:Doxorubicin / Q000633:toxicity*; D004996:Ethidium / Q000633:toxicity*; D006801:Humans; D006825:Hybridomas / Q000187:drug effects* / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects*; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology*; D013268:Stimulation, Chemical; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000276:immunology
D007136:Immunoglobulins; D004317:Doxorubicin; D004996:Ethidium
Adaptivnyĭ otvet B-kletok v kul'ture na deĭstvie tsitotoksicheskikh agentov. I. Stimuliatsiia sinteza i sekretsii immunoglobulinov kletkami mielom, gibridomy i limfotsitami cheloveka pod vliianiem adriamitsina i bromistogo étidiia.