[Levels of beta-endorphin in serum of patients with chronic renal failure treated with hemodialysis during a test which stimulates hypoglycemia after insulin].
In patients with chronic renal failure (CRF) an elevated serum beta-endorphin (BE) level and lack of a twenty-four-hour BE-secretory pattern were found. BE and other opioid peptides participate significantly in the development of the uremic syndrome and its complications. On the other hand hemodialytic treatment is an important factor influencing the concentration of most hormones. In healthy subjects insulin-induced hypoglycemia as well as exogenous corticotropin releasing hormone (CRH) produce a rise in serum BE since BE, beta-lipotropin and ACTH come from the common precursor proopiomelanocortin (POMC). This paper intended to evaluate the curve of serum BE concentration during such a test in uremic patients on hemodialytic treatment. 13 patients with CRF hemodialysed 4 to 38 months (mean: 17 months) and 14 healthy subjects were examined. In each of them crystalline insulin (0.1 units/kg of body mass) was given intravenously and blood samples were collected every 30 minutes. BE concentration was measured by radioimmunoassay without previous chromatographic separation. The test was performed after an overnight rest in the morning in persons staying at the recumbent position. An adequate hypoglycemia was obtained in every subject. Basal serum BE concentration was significantly higher in patients with CRF than in healthy subjects and correlated positively with duration of hemodialytic treatment. After 60 min. from insulin injection in both groups the peak BE level was observed whereas after 120 min. in returned to the initial values. The curve of BE concentration in patients with CRF ran on a significantly higher level than in healthy subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
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Oddział Nefrologii i Odział Sztucznej Nerki, Specjalistyczny Szpital Miejski Stalownik, Bielsku-Białej.
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D000328:Adult; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood*; D007328:Insulin; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D006435:Renal Dialysis; D001615:beta-Endorphin / Q000097:blood*
D007328:Insulin; D001615:beta-Endorphin
Stezenie beta-endorfiny w surowicy krwi u chorych z przewlekła niewydolnościa nerek leczonych hemodializami w teście stymulacji hipoglikemia poinsulinowa.