title: Linkage detection by the Affected-Pedigree-Member method: what is really tested?
abstract: We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
authors.affiliation: INSERM, Unité 155, Paris, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Babron
authors.forename: M
authors.initials: M
authors.lastname: Martinez
authors.forename: C
authors.initials: C
authors.lastname: Bonaïti-Pellié
authors.forename: F
authors.initials: F
authors.lastname: Clerget-Darpoux
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D002869:Chromosome Aberrations / Q000453:epidemiology / Q000235:genetics; D025063:Chromosome Disorders; D002888:Chromosomes, Human, Pair 19; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D009657:North Carolina / Q000453:epidemiology; D010375:Pedigree; D013223:Statistics as Topic / Q000379:methods
chemical_list: D005819:Genetic Markers