Is 5HT1A receptor subsensitivity a trait marker for late luteal phase dysphoric disorder? A pilot study.
Prolactin responses to buspirone challenges were examined in seven women with late luteal phase dysphoric disorder and the same number of healthy controls. The responses were found to be blunted during the follicular phase in the women with LLPDD suggesting that 5-HT1A receptor subsensitivity is perhaps a trait rather than a state marker for LLPDD.
Yatham
L N
LN
Department of Psychiatry, Nova Scotia Hospital, Dartmouth.
D000284:Administration, Oral; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002065:Buspirone; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000502:physiology*; D010865:Pilot Projects; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D011388:Prolactin / Q000097:blood*; D011446:Prospective Studies; D011985:Receptors, Serotonin / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1
D015415:Biomarkers; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D011388:Prolactin; D002065:Buspirone