Ageing and blood pressure regulation: dose-response relationships for angiotensin, blood pressure, atrial natriuretic peptide and aldosterone in normal subjects of varying ages.
1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) but not with age. 3. This is consistent with the response of ANP to AII being mediated partly by the rise in blood pressure, independent of ageing. 4. As expected in a selected normotensive population, there was no correlation between basal blood pressure and age, but pressor slope was positively correlated with age. 5. Thus, dose-response relationships may be an index of age-induced alterations in pressure regulatory mechanisms.
Finn
W L
WL
University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Australia.
Tunny
T J
TJ
Klemm
S A
SA
Ryan
S J
SJ
Gordon
R D
RD
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D000804:Angiotensin II; D000450:Aldosterone; D009320:Atrial Natriuretic Factor