Endothelial denudation in HHL-rabbit aortas.
The purpose of this study has been to develop a rabbit model for the assessment and follow up of angioplastic techniques which would be comparable to human arteriosclerosis. Segments of the abdominal aortas of 10 homozygous Heritable Hyperlipidemic rabbits were treated with 2 endothelial denudation procedures and collected at sacrifice after 1 week, 1 month, 2 or 3 months. Nondenuded segments of the 3 month group were taken as native controls. All sections were stained with hematoxilin/eosin and Elastica van Gieson. Pronounced intimal thickening with fibrosis, sometimes with atheromatosis developed after 1, 2, and 3 months. After 2 months calcium deposits and after 3 months frayed inner elastic membranes were found. The control segments revealed a lesser pathogenic expression with intact inner elastic membranes. In conclusion, a substantial increase in the pathogenic expression or the development of stenoses could not be obtained by 2 endothelial denudation procedures at the age of about 5 months.
Möller
K O
KO
Klinik für Chirurgie, Medizinische Universität zu Lübeck.
Lind
B M
BM
Baretton
G
G
D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics / Q000473:pathology*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006720:Homozygote; D006949:Hyperlipidemias / Q000235:genetics / Q000473:pathology*; D006938:Hyperlipoproteinemia Type II / Q000235:genetics / Q000473:pathology; D008297:Male; D011817:Rabbits; D017539:Tunica Intima / Q000473:pathology