Isoniazid induced encephalopathy in dialysis patients.
Three dialysis patients with extrapulmonary tuberculosis developed confusion 4-14 days after commencement of treatment with anti-tuberculosis drugs, despite the use of prophylactic pyridoxine. Full recovery of conscious state resulted within 1 week in all patients after stopping isoniazid. In 2 patients confusion recurred on rechallenge of the drug. The risk factors of isoniazid induced encephalopathy and the dosage of isoniazid in uraemic patients were discussed.
Cheung
W C
WC
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
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Cheng
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D000328:Adult; D003221:Confusion / Q000139:chemically induced* / Q000517:prevention & control; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000150:complications; D008875:Middle Aged; D011736:Pyridoxine / Q000627:therapeutic use; D006435:Renal Dialysis; D014376:Tuberculosis / Q000150:complications
D011736:Pyridoxine; D007538:Isoniazid