title: Isolated pontine lesion in algid cerebral malaria: clinical features, management, and magnetic resonance imaging findings.
abstract: Malaria, the most important of all tropical diseases, causes approximately one million deaths per year. In Plasmodium falciparum malaria, the organs most affected are the brain, kidneys, lungs, and liver. Cerebral involvement is the most important lethal complication with a mortality rate of up to 50%. We report a patient with malignant, tertian falciparum malaria with an initial parasitemia rate of 60% and severe cerebral, hepatorenal, and pulmonary involvement. In addition to the severe diffuse encephalopathy, an initial neurologic examination showed signs of a pontine lesion that was confirmed by cerebral magnetic resonance imaging. We therefore conclude that cerebral malaria may be responsible for focal neurologic lesions that can be demonstrated by this procedure.
authors.affiliation: Department of Neurology, University Hospital, Innsbruck, Austria.
authors.forename: A W
authors.initials: AW
authors.lastname: Kampfl
authors.forename: G G
authors.initials: GG
authors.lastname: Birbamer
authors.forename: B E
authors.initials: BE
authors.lastname: Pfausler
authors.forename: H P
authors.initials: HP
authors.lastname: Haring
authors.forename: E
authors.initials: E
authors.lastname: Schmutzhard
mesh_terms: D000328:Adult; D016913:Blood Component Transfusion; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D016779:Malaria, Cerebral / Q000473:pathology* / Q000628:therapy; D015767:Mefloquine / Q000627:therapeutic use; D010949:Plasma; D011149:Pons / Q000473:pathology*; D011803:Quinine / Q000627:therapeutic use
chemical_list: D011803:Quinine; D015767:Mefloquine