title: Echo-planar MR imaging of human brain oxygenation changes.
abstract: Echo-planar magnetic resonance (MR) imaging was used to observe signal intensity changes in the human brain during hypoxia. Increasing arterial blood levels of deoxyhemoglobin (0%-42%) during prolonged apnea were monitored with a pulse oximeter and correlated with gray matter and white matter signal attenuation of 13% and 20%, respectively. The results suggest the possibility of using deoxyhemoglobin boluses as a physiologic, intravascular susceptibility contrast agent for assessment of local cerebral oxygen utilization.
authors.affiliation: Department of Neurosurgery, University of Erlangen, Germany.
authors.forename: M K
authors.initials: MK
authors.lastname: Stehling
authors.forename: F
authors.initials: F
authors.lastname: Schmitt
authors.forename: R
authors.initials: R
authors.lastname: Ladebeck
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D000860:Hypoxia / Q000097:blood; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen