Further analysis of ricin's pyrogenic effect.
Ricin (RIC) the toxic protein of castor oil seeds (Ricinus communis, Euphorbiaceae;) given intraperitoneally in sublethal doses causes fever in a dose-dependent manner in the following mammals: rabbit, cat, guinea pig, rat and vervet monkey. This hitherto unknown property of ricin calls attention to its use as a pyrogen-substance in the pharmacological screening of new antipyretic drugs.
Balint
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GA
Dept. of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000818:Animals; D002415:Cats; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D011749:Pyrogens / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012276:Ricin / Q000633:toxicity*; D013045:Species Specificity
D011749:Pyrogens; D012276:Ricin