[Clinical observation of the effect of pretreatment with nifedipine in preventing oxygen free radicals in the cardiopulmonary release bypass operation].
The effect of pretreatment with nifedipine in preventing oxygen free radicals release was observed in the cardiopulmonary bypass (CPB) operation. Twenty cases were divided into two groups for comparison. Nifedipine (0.6 mg/kg) was given to the test group. MDA, XO, UA and SOD were measured. These examinations were taken at pre-aortic clamping, 15 min after aortic clamping, and 30, 60, 120, 180 min after reperfusion. The results indicated that pretreatment with nifedipine reduced oxygen free radicals release in the CPB operation.
Xiao
X
X
Tian
Z
Z
Wu
X
X
Yin
Q
Q
Huang
X
X
Yuan
H
H
Shi
Y
Y
D000293:Adolescent; D000328:Adult; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006330:Heart Defects, Congenital / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009543:Nifedipine / Q000627:therapeutic use*; D010100:Oxygen / Q000378:metabolism; D011292:Premedication; D013482:Superoxide Dismutase / Q000378:metabolism*
D005609:Free Radicals; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D009543:Nifedipine; D010100:Oxygen