Antioxidant enzymes in the liver of rats treated with carbon-tetrachloride after parathyroidectomy.
Liver of rats treated with carbon-tetrachloride (CCl4) after parathyroidectomy (unilateral as well as bilateral) showed decreased malondialdehyde and increased glutathione levels. Activities of glutathione dependent enzymes, viz.: glutathione peroxidase and glutathione reductase and another anti-peroxidative enzyme, i.e. catalase, have been correlated with decreased rate of lipid peroxidation. Present experimental evidence suggests that removal of the parathyroid gland(s) results in hypocalcemic conditions that inhibit the generation of hydroperoxides through antioxidant enzymes.
Rana
S V
SV
Department of Zoology, Meerut University, India.
Rastogi
S
S
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D016105:Parathyroidectomy; D010741:Phospholipases A / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D002251:Carbon Tetrachloride; D002374:Catalase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D010741:Phospholipases A; D005978:Glutathione; D002118:Calcium