title: Doxorubicin, mitomycin C and 5-fluorouracil in the treatment of hormone refractory adenocarcinoma of the prostate: a Southwest Oncology Group study.
abstract: In a Southwest Oncology Group phase II clinical trial, 68 patients with hormone refractory carcinoma of the prostate were treated with a combination of doxorubicin, mitomycin C and 5-fluorouracil. Of the patients 11 were classified as good risk and 57 as poor risk. There were 1 complete and 10 partial remissions for a response rate of 16.2% (exact 95% confidence interval 8.4 to 27.1%). Median survival was 9 months (maximum 14) for good risk patients and 10 months (maximum 42) for poor risk patients. Toxicity was significant with leukopenia identified as dose limiting. Because of the low rate of response and significant toxicity, this regimen cannot be recommended as standard therapy for metastatic hormone refractory prostate cancer.
authors.affiliation: Southwest Oncology Group Statistical Center, Seattle, Washington.
authors.forename: B
authors.initials: B
authors.lastname: Blumenstein
authors.forename: E D
authors.initials: ED
authors.lastname: Crawford
authors.forename: J H
authors.initials: JH
authors.lastname: Saiers
authors.forename: R L
authors.initials: RL
authors.lastname: Stephens
authors.forename: S E
authors.initials: SE
authors.lastname: Rivkin
authors.forename: C A
authors.initials: CA
authors.lastname: Coltman
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate
chemical_list: D016685:Mitomycin; D004317:Doxorubicin; D005472:Fluorouracil