Nucleolar changes in the oocytes of newborn rats treated with follicle stimulating hormone (FSH).
In the ovaries of newborn rats the exogenous follicle stimulating hormone (FSH) given in a large dose leads to the appearance of uncommon structures in the nucleoli of the oocytes. Fuzzy filaments sometimes with chiasma-like connections appear and ring-like structures in connection with, or independent of, the nucleoli are seen. The results demonstrate the possible appearance of a morphological response of oocytes to FSH prior to any detectable biochemical or receptor binding evidence.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Madarász
B
B
D000818:Animals; D000831:Animals, Newborn; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D008854:Microscopy, Electron; D009865:Oocytes / Q000187:drug effects / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar
D005640:Follicle Stimulating Hormone