title: Chromosome typing in lymphangioleiomyomatosis of the lung with and without tuberous sclerosis.
abstract: Two cases of lymphangioleiomyomatosis (LLM) of the lungs are compared, one with tuberous sclerosis and the other representing an isolated lung involvement. An increased frequency of complex chromosomal rearrangements was found in peripheral lymphocytes of the patient with tuberous sclerosis, in comparison to the patient with isolated lymphangioleiomyomatosis. Telomeric associations were found in cultured pulmonary smooth muscle cells from the patient with isolated LLM.
authors.affiliation: Institute of Pathology, University of Graz, Medical School, Austria.
authors.forename: H H
authors.initials: HH
authors.lastname: Popper
authors.forename: R
authors.initials: R
authors.lastname: Gamperl
authors.forename: M G
authors.initials: MG
authors.lastname: Pongratz
authors.forename: P
authors.initials: P
authors.lastname: Kullnig
authors.forename: F M
authors.initials: FM
authors.lastname: Jüttner-Smolle
authors.forename: R
authors.initials: R
authors.lastname: Pfragner
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007621:Karyotyping; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008203:Lymphangiomyoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D014402:Tuberous Sclerosis / Q000150:complications / Q000235:genetics*