title: Thrombolytic treatment for massive thrombosis of prosthetic cardiac valves.
abstract: OBJECTIVE
  To present the efficacy of thrombolytic treatment in place of emergency surgery in massive thrombosis of prosthetic cardiac valves (TPCV), and to set out the diagnostic criteria and the patients' evolution.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Coronary Care Unit of a Spanish reference hospital.
  
  
  METHODS
  7 patients admitted into the ICU with 10 episodes of TPCV and with advanced functional class.
  
  
  METHODS
  The diagnosis of TPCV was arrived at through clinical data and was confirmed by Doppler-echocardiography before treatment. Thrombolytic treatment (streptokinase, urokinase or rt-PA) was used. The analysis of paired samples between the data before and after treatment was used.
  
  
  RESULTS
  All the patients underwent an improvement in their clinical condition. A reduction of sPAP and in the mean transprosthetic gradient and an increase in the effective valvular area was achieved. Four patients needed surgical intervention during their follow-up. No case required emergency surgery. One patient died after surgery and the other 6 patients are alive after follow-up of 6-33 months. With the fibrinolytic treatment hemorrhagic complications were always controlled. None of the treated patients presented embolic complications.
  
  
  CONCLUSIONS
  Fibrinolytic treatment is the recommended initial treatment in cases of massive TPCV. When fibrinolysis is only partially successful, reoperation can be performed at lower risk. Doppler echocardiography is fundamental in the diagnosis of TPCV and in monitoring the response to fibrinolytic treatment.
authors.affiliation: Intensive Care Unit, General Hospital Virgen de las Nieves, Granada, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Guerrero López
authors.forename: G
authors.initials: G
authors.lastname: Vázquez Mata
authors.forename: A
authors.initials: A
authors.lastname: Reina Toral
authors.forename: I
authors.initials: I
authors.lastname: Rodríguez Bailón
authors.forename: E
authors.initials: E
authors.lastname: Fernández Mondéjar
authors.forename: P
authors.initials: P
authors.lastname: Aranegui Lasuen
mesh_terms: D000328:Adult; D003325:Coronary Care Units; D015150:Echocardiography, Doppler; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D011475:Prosthesis Failure; D012189:Retrospective Studies; D013300:Streptokinase / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy* / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D013300:Streptokinase; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator