title: Study of morphological manifestations of pulmonary arteries in experimental pulmonary hypertension provoked by administration of long-term, low-dose Na2EDTA--especially in aneurysmal changes and plexiform-like lesions.
abstract: In a previous paper (Yamaguchi et al. 1991) we informed that the administration of 1 ml. of 6% Na2EDTA every day intraperitoneally for two months led to the death of the guinea pigs, and autopsy revealed that the causes of death were right ventricular rupture ("rupturing") or severe right heart failure which was observed as extraordinary dilatation of the right ventricle ("non-rupturing"). The two different morphological causes of death were site dependent on the constriction of the pulmonary arteries, and the pulmonary arteries showed a fairly unique morphology. To analyze the morphological manifestations of the pulmonary arteries which were observed in the cases of extraordinarily dilated and thin ventricular luminal wall a decreased dose of Na2EDTA was administered every day for six months in order to maintain a reasonably long life of the animals through prevention of right ventricular rupture. In addition to the morphological manifestations reported in the previous paper, the longer term constriction of pulmonary arteries provoked aneurysmal changes, partially or totally, and the plexiform-like lesions which have been thought to be the most characteristic morphological one in pulmonary hypertension. The formative mechanisms are discussed.
authors.affiliation: Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Kaku
authors.forename: M
authors.initials: M
authors.lastname: Morisada
mesh_terms: D000783:Aneurysm / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D004492:Edetic Acid / Q000008:administration & dosage; D005260:Female; D006168:Guinea Pigs; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D011651:Pulmonary Artery / Q000473:pathology*; D013997:Time Factors
chemical_list: D004492:Edetic Acid