Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.
Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using monoclonal antibodies, IL-1 prolonged the in vitro survival of polymorphonuclear cells (PMN) through IL-1R I, and IL-4 antagonized the action of IL-1 by inducing expression and release of IL-1R II. Dexamethasone also induced expression and release of the IL-1R II in PMN. These results, together with the effect of antibodies to IL-1R on IL-1-induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1. The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action.
Colotta
F
F
Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Re
F
F
Muzio
M
M
Bertini
R
R
Polentarutti
N
N
Sironi
M
M
Giri
J G
JG
Dower
S K
SK
Sims
J E
JE
Mantovani
A
A
D000911:Antibodies, Monoclonal; D002470:Cell Survival / Q000276:immunology; D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000502:physiology*; D015847:Interleukin-4 / Q000502:physiology*; D008970:Molecular Weight; D009000:Monocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D017472:Receptors, Interleukin-1 / Q000145:classification / Q000187:drug effects / Q000502:physiology*
D000911:Antibodies, Monoclonal; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D015847:Interleukin-4; D003907:Dexamethasone