Microvascular density of the human paraventricular nucleus decreases with aging but not hypertension.
Microvascular density was determined in the supraoptic nuclei (SON) and paraventricular nuclei (PVN) of fixed brain tissue from 19 human subjects ranging in age from 30 to 85 years. Eight of these patients had hypertension. No sex- or hypertension-related differences in microvascular density were found in either the SON or PVN. However, capillary density decreased in the PVN with aging. These results indicate a differential pattern of microvascular loss in the human hypothalamus with aging.
Abernethy
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WB
Department of Radiology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1088.
Bell
M A
MA
Morris
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M
Moody
D M
DM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000502:physiology; D002196:Capillaries / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology; D008875:Middle Aged; D010286:Paraventricular Hypothalamic Nucleus / Q000098:blood supply*; D013495:Supraoptic Nucleus / Q000098:blood supply*