Lipids, lipoproteins and other coronary risk factors in Chinese male survivors of myocardial infarction.
OBJECTIVE
To assess the importance of an abnormal lipid profile as a risk factor in relation to non-biochemical risk factors, and to define the risk levels for lipid, lipoprotein and apolipoprotein in a Chinese population.


METHODS
Serum lipids, lipoproteins, apolipoproteins and other cardiovascular risk factors were studied in 89 Chinese men 3 months after acute myocardial infarction and 56 controls.


RESULTS
Cases had higher mean total cholesterol (TC), LDL- and VLDL-cholesterol, triglycerides and apolipoprotein B (Apo B), and lower mean HDL-cholesterol and apolipoprotein AI (Apo AI). Mean BMI was also higher, as was the prevalence of smokers and subjects with a history of hypertension. In univariate analysis, the odds ratios for TG > or = 1.6 mmol/l, LDL-cholesterol > or = 4.1 mmol/l, VLDL-cholesterol > or = 0.73 mmol/l, Apo B > or = 104 mg/dl were of the same order of magnitude as being a current smoker, having a BMI > or = 24.3 kg/m2, and a history of hypertension. High HDL-cholesterol (> or = 1.39 mmol/l) and Apo AI (> or = 139 mg/dl) were protective factors. The odds ratios for successively higher quartile values of cholesterol were not statistically significant. Multiple logistic regression identified smoking habit, history of hypertension, obesity, high Apo B and low Apo AI concentrations as independent risk factors for myocardial infarction.


CONCLUSIONS
In a Chinese population, low serum Apo AI and high Apo B are risk factors for myocardial infarction of a comparable magnitude to smoking, hypertension and obesity.
Woo
J
J
Department of Medicine, Chinese University of Hong Kong.
Ho
S C
SC
Wong
S L
SL
Woo
K S
KS
Tse
C Y
CY
Chan
K K
KK
Kay
C S
CS
Mak
W P
WP
Cheung
K O
KO
Lam
C W
CW
D016632:Apolipoprotein A-I / Q000032:analysis*; D001055:Apolipoproteins B / Q000097:blood*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D048909:Diabetes Complications; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications; D006973:Hypertension / Q000150:complications; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D016015:Logistic Models; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D009765:Obesity / Q000150:complications; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D015996:Survival Rate
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008055:Lipids; D008074:Lipoproteins