title: Significance of MRI changes after surgery of the skull base.
abstract: Magnetic resonance (MR) imaging is commonly used in the followup of patients who have undergone surgical removal of tumors from the cranial base to assess the possibility of tumor recurrence, persistence, or surgical complications. Interpretations of this study must be cautious because postoperative enhanced signals are encountered frequently. Although technological improvements continue to enhance the usefulness of MR images for followup, problems remain in differentiating between fibrotic, reconstructive changes, and tumor recurrence. In this study, the hospital records and MR findings of 215 patients who had undergone skull base surgery were reviewed. The study was prompted by negative operative exploration in three patients in whom postoperative MR images strongly suggested tumor recurrence. One-year follow-up images were available in 174 patients. Of these, 94% showed signal enhancement on the 1-year follow-up study. Progressive changes were observed in 14% of patients. The correlation of preoperative MR findings and surgery, with regard to dural involvement, vascular involvement, cranial nerve infiltration, and extent of intracranial infiltration, was analyzed in 28 patients. Methods to facilitate the detection of tumor recurrence using MR images are reviewed.
authors.affiliation: Division of Otolaryngology, University of Mississippi Medical Center, Jackson 39216-4505.
authors.forename: V K
authors.initials: VK
authors.lastname: Anand
authors.forename: J P
authors.initials: JP
authors.lastname: Arrowood
authors.forename: R B
authors.initials: RB
authors.lastname: Patel
authors.forename: J P
authors.initials: JP
authors.lastname: Leonetti
authors.forename: O
authors.initials: O
authors.lastname: al-Mefty
mesh_terms: D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D011184:Postoperative Period; D015995:Prevalence; D012086:Reoperation; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery