[ANP changes induced by varying TSH].
Aim of our study was estimating if TSH could influence the timing of ANP release. About it we observed 70 male subjects: 40 were euthyroid patients aged 42 +/- 5 years (group A); 20 patients treated by thyroxine in doses sufficient for inhibiting TSH release, aged 45 +/- 7 years (group B). A third group (C) was composed by 10 subjects with high basal levels of serum T3 and T4 with no thyrostatic therapy, aged 40 +/- 9 years. These subjects underwent a TRH test estimating at -30', 0', 30', 60', 120' plasma concentrations of TSH, ANP, T3, T4. In reply to physiological stimulus induced on patients of group A we observed a significant increase of TSH values (max at 60') and ANP levels (max at 120'). No significant variations occurred during the TRH test in T3 and T4 concentrations. In groups B and C no important modifications were observed neither in TSH nor in ANP plasma levels. ANP secretion seems to be dependent from the secretory condition of hypothalamus-pituitary-thyroid axis both in physiological and pathological conditions.
Testa
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Istituto di Clinica Medica, Università degli Studi di Ancona.
Rasetti
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C
Ippoliti
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M
Boni
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M
De Sio
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G
Recchioni
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A
Testa
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R
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007037:Hypothyroidism / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012636:Secretory Rate / Q000187:drug effects; D013961:Thyroid Gland / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism; D013972:Thyrotropin / Q000502:physiology*; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000494:pharmacology / Q000627:therapeutic use
D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone; D009320:Atrial Natriuretic Factor; D013972:Thyrotropin; D013974:Thyroxine
Modificazioni dell'ANP indotte da variazioni del TSH.