Transient neonatal hypercholesterolemia. Lack of relationships with dehydroepiandrosterone sulfate.
In order to obtain new information about the relationship between transient neonatal hypercholesterolemia and adrenal gland function, we have studied 39 healthy babies found hypercholesterolemic at birth and 39 healthy controls with normal cholesterol levels. The results of this study have shown that levels of dehydroepiandrosterone sulfate in cord blood were not significantly different in the hypercholesterolemic subjects compared with normolipidemic controls (1.4 +/- 0.5 micrograms/dl vs 1.3 +/- 0.5 mu/dl). Moreover correlations between this hormone and levels of total and LDL-cholesterol were not only not statistically significant but even positive (respectively r = +0.207 and +0.195). These data suggest that dehydroepiandrosterone sulfate measurements in cord blood do not give any further information about transient neonatal hypercholesterolemia.
Averna
M R
MR
Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy.
Barbagallo
C M
CM
Di Paola
G
G
La Placa
F P
FP
Scafidi
V
V
Dimita
U
U
Notarbartolo
A
A
D000311:Adrenal Glands / Q000502:physiology; D001053:Apolipoproteins / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology*; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood
D001053:Apolipoproteins; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate