Lack of association between antiphospholipid antibodies and migraine.
We prospectively studied the prevalence of lupus anticoagulant, anticardiolipin antibodies (aCL) and various haemostatic parameters in 71 patients with migraine and compared the results with a control group of 32 subjects with back pain never having experienced migraine. The patients with migraine were divided into two groups: group I with migraine without (n = 18) and with aura lasting less than 60 min (n = 24) and group II with migraine with prolonged aura or migrainous infarction (complicated migraine, n = 29). The following results were obtained: a) no difference in aCL positivity was noted between migrainous patients and controls and between common migraine and complicated migraine patients and b) no statistically significant difference in haemostatic parameters (except for thrombin-antithrombin III complexes) was found between the two groups of migraine and between aCL positive and negative migrainous patients. These data suggest that anticardiolipin antibodies are not involved in the pathogenesis of migraine complications.
Tsakiris
D A
DA
Coagulation and Fibrinolysis Laboratory, University Hospital of Basel, Switzerland.
Kappos
L
L
Reber
G
G
Marbet
G A
GA
Le Floch-Rohr
J
J
Roux
E
E
de Moerloose
P
P
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D000990:Antithrombin III / Q000032:analysis; D001416:Back Pain / Q000097:blood / Q000276:immunology; D001798:Blood Proteins / Q000032:analysis; D002544:Cerebral Infarction / Q000209:etiology; D005260:Female; D006487:Hemostasis; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000145:classification / Q000150:complications / Q000276:immunology*; D010447:Peptide Hydrolases / Q000032:analysis; D011446:Prospective Studies
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D001798:Blood Proteins; D016682:Lupus Coagulation Inhibitor; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases