Measurements of cerebral blood flow and metabolism in severe head injury using the Kety-Schmidt technique.
Global cerebral blood flow (CBF) was measured serially for up to 10 days after severe head injury, and related to outcome. Twenty-five of the patients had a reduced CBF, 47 had a normal CBF, and 30 had an elevated CBF. Patients with a reduced CBF had a poorer outcome than patients with a normal or elevated CBF. There were no differences in the type of injury, initial GCS, severity of intracranial hypertension in each CBF group. Systemic factors did not significantly contribute to the differences in CBF among the 3 groups. A logistic regression model of the effect of CBF on neurological outcome was developed. When adjusted of variables which were found to be significant confounders, including age, initial Glasgow Coma Score, hemoglobin, cerebral perfusion pressure, and cerebral oxygen consumption, a reduced CBF remained significantly associated with an unfavorable neurological outcome.
Robertson
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Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
D000328:Adult; D001921:Brain / Q000098:blood supply*; D001925:Brain Damage, Chronic / Q000401:mortality / Q000503:physiopathology*; D001930:Brain Injuries / Q000401:mortality / Q000503:physiopathology*; D003422:Critical Care; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D016489:Head Injuries, Closed / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009609:Nitrous Oxide; D010101:Oxygen Consumption / Q000502:physiology; D011379:Prognosis; D015996:Survival Rate; D014948:Wounds, Gunshot / Q000401:mortality / Q000503:physiopathology
D009609:Nitrous Oxide