[The pathogenetic basis for using antiestrogens in treating patients with hyperplastic processes of the endometrium in the postmenopause].
Estradiol and progesterone cytosol receptors, tamoxifen relative binding capacity in endometrial tissue samples, serum estradiol and progesterone levels were studied in 60 postmenopausal patients with hyperplastic processes in the endometrium. Estradiol and progesterone receptor levels were increased in glandular cystic polyp tissue, in atypical hyperplastic tissue samples, and in well-differentiated adenocarcinoma tissue. High estradiol levels were detected in the blood sera of patients with glandular cystic polyps, atypical and glandular hyperplasia. Tamoxifen relative binding capacity was the highest in glandular cystic polyps and glandular hyperplasia. Forty patients were treated with 17-hydroxyprogesterone capronate. The data on the status of cytosol receptors and tamoxifen relative binding capacity as well as clinical findings give grounds to include antiestrogens into therapeutic complex for postmenopausal patients with endometrial hyperplasia.
Vysotskiĭ
M M
MM
Krasnova
I A
IA
Kostyleva
O I
OI
Eremin
V L
VL
D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003600:Cytosol / Q000737:chemistry; D004714:Endometrial Hyperplasia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004717:Endometrium / Q000737:chemistry / Q000473:pathology; D004958:Estradiol / Q000097:blood; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D011374:Progesterone / Q000097:blood; D011959:Receptors, Estradiol / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
D004965:Estrogen Antagonists; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol
Patogeneticheskoe obosnovanie primeneniia antiéstrogenov v lechenii bol'nykh s giperplasticheskimi protsessami éndometriia v periode postmenopauzy.