Delayed cardiotoxicity following quinine overdose: a case report.
Quinine poisoning typically results in a constellation of non-life threatening symptoms which include tinnitus, deafness, nausea, vomiting, vision changes, headache, and hypotension. Cardiac conduction defects, dysrhythmias, and cardiovascular collapse have all been reported after overdose and generally occur within 8 hours of ingestion. We report a unique case of delayed cardiotoxicity following quinine ingestion. Toxicity included marked ventricular conduction abnormalities for which serum alkalinization appeared to be therapeutically beneficial, and torsades de pointes requiring overdrive pacing for termination.
Bodenhamer
J E
JE
Department of Emergency Medical Services, Denver General Hospital, Colorado 80204-4507.
Smilkstein
M J
MJ
D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D011803:Quinine / Q000506:poisoning*; D013406:Suicide, Attempted; D013997:Time Factors; D016171:Torsades de Pointes / Q000139:chemically induced
D011803:Quinine