title: Theoretical considerations for the design and development of a drug: influence of pharmacokinetics and dosage regimen on receptor interactions.
authors.affiliation: Genentech Inc., South San Francisco, California 94080.
authors.forename: J
authors.initials: J
authors.lastname: Mordenti
authors.forename: A
authors.initials: A
authors.lastname: Rescigno
mesh_terms: D001665:Binding Sites; D004334:Drug Administration Schedule; D015195:Drug Design; D008433:Mathematics; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000493:pharmacokinetics; D010599:Pharmacokinetics; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011955:Receptors, Drug / Q000378:metabolism*; D013454:Sulfoxides / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors; D011955:Receptors, Drug; D013454:Sulfoxides; C074915:G 4120