[Characterization of enterobacteria producing the broad-spectrum antibiotics microcins].
As a result of screening among 11956 enterobacteria strains isolated from feces of normal children, grown-ups and lambs, seven active microcin-producing strains were obtained. The microcins were shown to be peptides or their derivatives with a low molecular weight (less than 10,000) and a broad spectrum of activity, mainly against gram-negative bacteria. According to cross immunity criteria the microcins studied belonged to two different types. Those of type I could be further classified into two subtypes on the account of difference in the spectrum of antibacterial activity. In 5 cases out of 7 the microcin-producing ability and immunity to microcins have been attributed to plasmids that the strains harboured. The effect of microcins on sensitive cells depended on ompR and ompF gene products.
Khmel'
I A
IA
Manokhina
I M
IM
Basiuk
E I
EI
Metlitskaia
A Z
AZ
Lipasova
V A
VA
Romanova
Iu M
IuM
Bondarenko
V M
VM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001430:Bacteriocins / Q000096:biosynthesis*; D004352:Drug Resistance, Microbial / Q000235:genetics; D004755:Enterobacteriaceae / Q000235:genetics / Q000378:metabolism*; D005798:Genes, Bacterial; D006801:Humans; D010957:Plasmids; D012756:Sheep
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C020411:microcin
Kharakteristika énterobakteriĭ, produtsiruiushchikh antibiotiki shirokogo spektra deĭstviia mikrotsiny.