Involvement of protein kinase C in various cellular systems transducting ischemia evoked signal.
(1) We favour a hypothesis that the delayed neuronal injury in hippocampus is initiated by the increase of intracellular calcium concentration, activating transiently Ca-dependent protein kinase. (2) The secondary effects of the postischemic, short-lasting PKC translocation/activation could involve: an activation of cAMP signaling pathway; an activation of early response protein like ornitine decarboxylase.
Zabłocka
B
B
Department of Neurochemistry, Polish Academy of Sciences, Warsaw.
Domańska-Janik
K
K
D000818:Animals; D002545:Brain Ischemia / Q000201:enzymology / Q000503:physiopathology*; D006624:Hippocampus / Q000201:enzymology / Q000502:physiology*; D006801:Humans; D011493:Protein Kinase C / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D011493:Protein Kinase C