title: [Oxidative phosphorylation uncoupling in hyperthyroidism as a result of activating cyclosporin-sensitive pores in the inner mitochondrial membrane by water soluble modulators from rat liver cytoplasm].
abstract: Small concentrations of low molecular weight modulators of the functional state of rat liver cytoplasm mitochondria, which uncouple oxidative phosphorylation, induce phosphate-dependent transport of potassium and hydrogen ions. In contrast, high concentrations of these compounds induce nonspecific transport of monovalent cations and sucrose (K+ > H+ > Na+ > or = Li+ > sucrose). The effect of cytoplasmic modulators on oxidative phosphorylation and permeability of the inner mitochondrial membrane in inhibited by cyclosporin A and controlled by physiological concentrations of Ca2+. It is assumed that ion transport across the inner mitochondrial membrane in the presence of cytoplasmic modulators is implemented by the same cyclosporin-sensitive transport system which in damaged mitochondria functions as a nonspecific pore.
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Gaĭnutdinov
authors.forename: V V
authors.initials: VV
authors.lastname: Konov
authors.forename: R N
authors.initials: RN
authors.lastname: Ishmukhamedov
authors.forename: T N
authors.initials: TN
authors.lastname: Zakharova
authors.forename: M A
authors.initials: MA
authors.lastname: Khalilova
authors.forename: M I
authors.initials: MI
authors.lastname: Asparov
mesh_terms: D000818:Animals; D001692:Biological Transport; D002412:Cations; D002463:Cell Membrane Permeability / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism*; D006980:Hyperthyroidism / Q000378:metabolism*; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010085:Oxidative Phosphorylation; D051381:Rats; D012995:Solubility; D013395:Sucrose / Q000378:metabolism; D014867:Water
chemical_list: D002412:Cations; D014867:Water; D013395:Sucrose; D016572:Cyclosporine
vernacular_title: Razobshchenie okislitel'nogo fosforilirovaniia pri gipertireoze kak sledstvie aktivatsii tsiklosporinchuvstvitel'noĭ pory vo vnutrenneĭ membrane mitokhondriĭ vodorastvorimymi moduliatorami iz tsitoplazmy pecheni krysy.