title: Reduced portosystemic hemodynamic responsiveness after orthostasis in patients with cirrhosis.
abstract: We studied portosystemic hemodynamic responsiveness after 1 min orthostasis in nine patients with cirrhosis and nine age-matched normal subjects. Orthostasis increased diastolic arterial pressure, which is a close indicator of arterial tone, in normal subjects (+17%, P < 0.01). In contrast, no significant change in diastolic arterial pressure was observed in patients with cirrhosis (-3%, NS). The increase in heart rate was less in patients with cirrhosis than in normal subjects (+15% vs +28%, P < 0.05). Orthostasis also decreased portal blood flow, which was assessed by an echo-Doppler flowmetry, in normal subjects (-27%, P < 0.01), but in patients with cirrhosis it was not modified (-3%, NS). Plasma noradrenaline concentration showed similar increase in both groups (normal vs cirrhosis; +61% vs +55%, NS). Although the change in plasma noradrenaline concentration was related with that in diastolic arterial pressure (r = 0.71, P < 0.05) and inversely with that in portal blood flow (r = -0.69, P < 0.05) in normal subjects, no such significant correlation was found in patients with cirrhosis. We conclude that (1) a reduced hemodynamic responsiveness to sympathetic stimulation exists on both systemic and portohepatic vascular beds and (2) such a blunted baroreflex function is probably located at the receptor or effector level in patients with cirrhosis.
authors.affiliation: Department of Medicine II, Kurume University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwao
authors.forename: A
authors.initials: A
authors.lastname: Toyonaga
authors.forename: M
authors.initials: M
authors.lastname: Ikegami
authors.forename: M
authors.initials: M
authors.lastname: Sumino
authors.forename: K
authors.initials: K
authors.lastname: Oho
authors.forename: M
authors.initials: M
authors.lastname: Sakaki
authors.forename: H
authors.initials: H
authors.lastname: Shigemori
authors.forename: K
authors.initials: K
authors.lastname: Tanikawa
authors.forename: J
authors.initials: J
authors.lastname: Iwao
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011168:Portal System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011187:Posture / Q000502:physiology*; D012044:Regression Analysis; D012083:Renin / Q000097:blood; D012212:Rheology / Q000706:statistics & numerical data; D014463:Ultrasonography
chemical_list: D012083:Renin; D009638:Norepinephrine