Differential effects of leukotriene C4 on endothelin-1 and prostacyclin release by cultured vascular cells.
Nanomolar concentrations of leukotriene C4 and phorbol 12-myristate acetate, a protein kinase C activator, stimulated endothelin-1 release by vascular endothelial but not smooth muscle cells. For both agonists, attenuation of this stimulatory effect was observed at higher concentrations, concomitant with but independent of enhanced prostacyclin biosynthesis.
Patrignani
P
P
Laboratory of Cardiovascular Pharmacology, University of Chieti, G. D. Annuzio School of Medicine, Italy.
Modica
R
R
Bertolero
F
F
Patrono
C
C
D015121:6-Ketoprostaglandin F1 alpha / Q000276:immunology / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D016232:Endothelins / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016232:Endothelins; D013189:SRS-A; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D013755:Tetradecanoylphorbol Acetate