[The effects of chronic cilazapril treatment on sympathetic vasomotor tonus: a spectral analysis study of pressure variability].
Animal experiments suggest that an important component of the antihypertensive effects of ACE inhibitors might derive from an inhibition of the sympathetic vasomotor tone. We addressed this problem on 22 mildly hypertensive subjects (48 +/- 2 years; arterial pressure 151 +/- 3/95 +/- 1 mmHg), in whom sympathetic vasomotor tone was non invasively inferred by the power of the low frequency component (0.1 Hz) of the spontaneous oscillations of systolic arterial pressure (LFSAP), during placebo and after 4 weeks of treatment with a new ACE inhibitor, cilazapril, 5 mg per os oid. LFSAP was computed at rest and during physical (active orthostatism) and mental (computerized attentional test and mental arithmetic) stimuli capable of enhancing sympathetic drive. Cilazapril treatment reduced resting arterial pressure to 128 +/- 3/80 +/- 2 mmHg, without affecting heart rate (78 +/- 2 and 74 +/- 2 b/min, respectively). The increases in LFSAP produced by standing were significantly greater during placebo than during active treatment (delta LFSAP = 10 +/- 3 and 5 +/- 2 mmHg2, respectively). These data suggest that an important reduction of sympathetic vasomotor tone accompanies the antihypertensive effects of chronic ACE-inhibitor treatment.
Pagani
M
M
Istituto Scienze Biomediche, Ospedale L Sacco, Università degli Studi, Milano.
Lucini
D
D
Pizzinelli
P
P
Brera
V
V
Sommariva
D
D
Di Michele
R
R
Malliani
A
A
D001794:Blood Pressure / Q000187:drug effects*; D002908:Chronic Disease; D017315:Cilazapril / Q000494:pharmacology* / Q000627:therapeutic use; D004341:Drug Evaluation; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus / Q000187:drug effects*; D012815:Signal Processing, Computer-Assisted; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D014666:Vasomotor System / Q000187:drug effects* / Q000503:physiopathology
D017315:Cilazapril
Effetti del trattamento cronico con cilazapril sul tono vasomotorio simpatico: studio con analisi spettrale della variabilità pressoria.