Antiendometrial autoantibodies are generated in patients with endometriosis.
OBJECTIVE
Our aim was to investigate endometrial antigens involved in the autoimmunity of endometriosis.


METHODS
We detected endometrial antigens against which autoantibodies directed with Western blotting.


RESULTS
Thirteen (72.2%), 14 (77.8%), and 15 (83.3%) of 18 serum samples from endometriosis patients had antibodies reactive against endometrial antigen wtih MW of 26 kd, 34 kd, and 42 kd, respectively, while 6 (33.3%), 8 (44.4%), and 8 (44.4%) of 18 samples from normal control women reacted against these antigens, respectively. The frequencies of antibodies to the endometrial antigens were significantly (P < 0.05) higher in the endometriosis patients than in the normal control women. Antibodies in peritoneal fluid (PF) reacted against antigens with MW of 26, 34, 38, 42, and 64 kd, while those from the normal control reacted against antigens with MW of 38, 42, and 64 kd. Serum samples from normal fertile males did not show any reactivity against these endometrial antigens.


CONCLUSIONS
Our results show that autoantibodies reactive against endometrial antigens are present in patients with endometriosis.
Gorai
I
I
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan.
Ishikawa
M
M
Onose
R
R
Hirahara
F
F
Minaguchi
H
H
D000328:Adult; D001202:Ascitic Fluid / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology*; D004715:Endometriosis / Q000276:immunology*; D004717:Endometrium / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
D001323:Autoantibodies; D001324:Autoantigens