Reduced total complement haemolytic activity in schizophrenic patients.
Serum concentrations of the third and fourth components of the complement system and total complement haemolytic activity were measured in 167 psychiatric patients. Total complement haemolytic activity was decreased in chronic schizophrenic patients as compared to healthy controls and bipolar patients. The relatively diminished total haemolytic activity was not attributable to drug treatment. It is not clear if the reduced total haemolytic activity is an epiphenomenon or related to the involvement of an autoimmune process in the pathophysiology of schizophrenia.
Spivak
B
B
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva, Israel.
Radwan
M
M
Brandon
J
J
Baruch
Y
Y
Stawski
M
M
Tyano
S
S
Weizman
A
A
D001327:Autoimmune Diseases / Q000276:immunology*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000276:immunology / Q000523:psychology; D002908:Chronic Disease; D003167:Complement Activation / Q000187:drug effects / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003866:Depressive Disorder / Q000188:drug therapy / Q000276:immunology / Q000523:psychology; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy / Q000276:immunology*; D012565:Schizophrenic Psychology
D003176:Complement C3; D003181:Complement C4; D016651:Lithium Carbonate; D006220:Haloperidol