[Effects of cyclosporine A on the distribution of a glucose load].
Cyclosporin A (CsA) is an immunosuppressive drug, but it has also a marked action on carbohydrate metabolism. This study was designed to define the role of a single CsA administration in glucose load distribution. Results show that CsA seems to modify glucose load distribution; in fact it influences considerably glycemia and hepatic, cardiac and muscular glycogen levels, particularly after glucose load. The present experiments suggest that CsA has an antagonist action on insulin release elicited by glucose. This effect may be due to a modification of Ca2+ cellular levels in pancreatic beta-cells. Reduction of insulin release may develop a "pharmacologic diabetes" with metabolism deviated towards gluconeogenesis.
Hopps
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Facoltà di Scienze MM. FF. e NN., Cattedra di Farmacologia, Università degli Studi di Palermo.
Vetri
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P
Biondi
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F
Fontana
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G
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005943:Gluconeogenesis / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D016572:Cyclosporine; D005947:Glucose
Effetti della ciclosporina A sulla distribuzione di un carico di glucosio.