Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients with remote metastasis.
Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients without remote metastasis were significantly higher than those in the control non-cancer patients. Moreover, these parameters in the cancer patients with remote (liver or lung) metastasis were significantly higher than those in the cancer patients without remote metastasis. After radical curative operations, these parameters were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B in the pathogenesis of tumor metastasis, and also suggest that these parameters might be possible indicators for tumor malignancy such as remote metastasis.
Hirano
T
T
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Manabe
T
T
Takeuchi
S
S
D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000737:chemistry / Q000652:urine; D002401:Cathepsin B / Q000032:analysis* / Q000097:blood / Q000652:urine; D003110:Colonic Neoplasms / Q000097:blood / Q000737:chemistry / Q000652:urine; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013274:Stomach Neoplasms / Q000097:blood / Q000737:chemistry / Q000652:urine
D002401:Cathepsin B