Mycobacterium avium antigenuria in patients with AIDS and disseminated M. avium disease.
A 22,500-Da antigen apparently specific to Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum has been identified by Western immunoblotting. By use of a dot immunoassay, this antigen was found in the urine of 64% of patients with AIDS and disseminated M. avium disease. It was not found in the urine of healthy control subjects. Detection of antigenuria might provide the basis for rapid diagnosis of M. avium disease in patients with AIDS.
Sippola
A A
AA
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Gillespie
S L
SL
Lewis
J A
JA
Daniel
T M
TM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000652:urine; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology / Q000652:urine*; D015153:Blotting, Western; D006041:Goats; D006801:Humans; D009161:Mycobacterium / Q000276:immunology; D009164:Mycobacterium Infections / Q000150:complications / Q000276:immunology*; D009162:Mycobacterium avium / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial