Stimulation of 5-HT1A and 5-HT2/5-HT1C receptors induce oxytocin release in the male rat.
Plasma oxytocin responses to the 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), buspirone and ipsapirone, and the 5-HT2/5-HT1C receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane (DOI) have been studied in conscious, freely moving male rats. All four compounds caused dose-related increases in plasma oxytocin concentrations after intravenous administration. Oxytocin responses to 8-OH-DPAT were significantly attenuated by pretreatment with the 5-HT1A receptor antagonist NAN-190 while responses to DOI were blocked by pretreatment with the 5-HT2/5-HT1C receptor antagonist ritanserin. Since vasopressin concentration did not change despite the marked elevation in plasma oxytocin, these results suggest that 5-HT1A and 5-HT2/5-HT1C receptors all stimulate oxytocin secretion, and this effect does not reflect a general neurohypophyseal hormone release.
Bagdy
G
G
Laboratory of Experimental Medicine, National Institute of Psychiatry and Neurology, Budapest, Hungary.
Kalogeras
K T
KT
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D002065:Buspirone / Q000494:pharmacology; D008297:Male; D010121:Oxytocin / Q000097:blood / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D000662:Amphetamines; D010879:Piperazines; D011743:Pyrimidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; D016713:Ritanserin; D010121:Oxytocin; C043077:ipsapirone; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine; D002065:Buspirone