title: A fluoroscopy-based computed tomography scanner for small specimen research.
abstract: OBJECTIVE
  A small-laboratory computed tomography (CT) system using a fluoroscopic system and a personal computer was fabricated and tested. The motivation for building this specimen scanner was to provide medical researchers with the capability of using CT as a practical tool in their research, as well as to provide an opportunity for hands-on CT instruction.
  
  
  METHODS
  The CT system was constructed using mostly off-the-shelf items; however, the CT stage itself was custom fabricated and software development was necessary. In addition, a personal computer and a standard fluoroscopy system were used.
  
  
  RESULTS
  The spatial resolution was found to match the 228-microns sampling limitation, yielding approximately 2 line pairs per mm. Iodine contrast sensitivity studies showed that 1% solution of 370 mg/ml iodine solution was easily detected (P = .05).
  
  
  CONCLUSIONS
  A small CT scanner for specimen research can be economically constructed, and is capable of good performance. The authors found substantial interest on the part of small animal researchers involved in a wide variety of medical research.
authors.affiliation: Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: J M
authors.initials: JM
authors.lastname: Boone
authors.forename: G M
authors.initials: GM
authors.lastname: Alexander
authors.forename: J A
authors.initials: JA
authors.lastname: Seibert
mesh_terms: D000818:Animals; D005471:Fluoroscopy; D008961:Models, Structural; D051381:Rats; D012984:Software; D015898:Tomography Scanners, X-Ray Computed