title: Double cardiomyoplasty: acute versus chronic results.
abstract: We previously found that double cardiomyoplasty using both acutely raised, unconditioned latissimus dorsi muscles increased cardiac output by 9.6% (1,547 +/- 154 versus 1,695 +/- 166 mL/min), stroke volume by 18.2% (12.1 +/- 0.6 versus 14.3 +/- 0.7 mL), peak left ventricular pressure by 18.4% (98 +/- 3 versus 116 +/- 5 mm Hg), and peak right ventricular pressure by 62.5% (24 +/- 2 versus 39 +/- 4 mm Hg) (p < 0.05 for all differences). In this study 10 dogs underwent double cardiomyoplasty: 3 died perioperatively, and 7 underwent 8 weeks of muscle conditioning. After the conditioning period, the muscle flaps did not contract in 2 of the 7 dogs. Hemodynamics were measured in the remaining 5 dogs. Using fatigue-resistant muscle, cardiac output decreased by 3.7% (1,279 +/- 262 versus 1,233 +/- 274 mL/min), stroke volume decreased by 9.0% (9.5 +/- 1.2 versus 8.8 +/- 1.2 mL), and peak left ventricular pressure increased by 10.6% (82.1 +/- 6.5 versus 90.8 +/- 3.2 mm Hg), but not significantly. Peak right ventricular pressure increased significantly by 31.3% (24.3 +/- 2.1 versus 31.9 +/- 3.6 mm Hg; p < 0.05). Hemodynamic effects of individual left or right muscle contractions versus bilateral muscle stimulation were not significantly different except for a greater percentage increase in peak right ventricular pressure (right, 24.9 +/- 2.1 mm Hg unstimulated versus 28.0 +/- 2.1 stimulated; left, 26.3 +/- 0.9 mm Hg unstimulated versus 30.7 +/- 2.4 mm Hg stimulated; bilateral, 24.3 +/- 2.1 mm Hg unstimulated versus 31.9 +/- 3.4 mm Hg stimulated; p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Cardiothoracic Surgery, Wayne State University, School of Medicine, Detroit, Michigan.
authors.forename: R
authors.initials: R
authors.lastname: Ruggiero
authors.forename: G A
authors.initials: GA
authors.lastname: Thomas
authors.forename: H
authors.initials: H
authors.lastname: Niinami
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: T L
authors.initials: TL
authors.lastname: Hooper
authors.forename: R L
authors.initials: RL
authors.lastname: Hammond
authors.forename: R
authors.initials: R
authors.lastname: Fietsam
authors.forename: F W
authors.initials: FW
authors.lastname: Mocek
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: H O
authors.initials: HO
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D002302:Cardiac Output; D006348:Cardiac Surgical Procedures; D004285:Dogs; D013318:Stroke Volume; D013524:Surgical Flaps; D016277:Ventricular Function, Left