Combined therapy of mitomycin C and Chinese medical herbs on experimental liver cancer.
In this research, ICR male mice were chosen for intrahepatic implantation of sarcoma 180 tumor cells (1 x 10(7)). The mice were randomly divided into various groups 24 hours after implantation. One of the groups was the tumor control, the others were singly or combinedly treated with mitomycin C (MMC) and Shih Chuan-Ta-Pu-Tang (SCTPT) or Shi-Hung-One (SHO). The results revealed that the mortality rate (MR60) in the tumor control was 100% and the mean survival time (MST60) was 21.11 +/- 10.69 days. The best therapeutic effect appeared in the group treated with the combination of MMC and SHO, its MR6o was 55.0% and MST 60 was 47.0 +/- 13.4 days.
Hau
D M
DM
Institute of Radiation Biology, National Tsing Hua University, Hsinchu, Taiwan.
Chen
T H
TH
Cheng
J F
JF
You
J S
JS
D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016685:Mitomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate
D004365:Drugs, Chinese Herbal; D016685:Mitomycin