Factors for osseous repair and delivery. Part I.
The healing fracture, autograft, and allograft repair are associated with a panoply of unique biochemical and cellular processes. Temporal harmony between the components of these processes can ensure restoration of form and function to bony deficiencies incurred as a consequence of developmental deformity, traumatic incident, or surgical resection. Part I of this editorial describes the chronobiology of the stages of several types of naturally occurring bone repair materials and the interaction of the component cells and their biochemical products. The emphasis is on growth and inductive factors, which are keys to promoting bone regeneration.
Hollinger
J
J
Department of Physiology, Walter Reed Army Medical Center, Washington, DC 20307-5300.
D000818:Animals; D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration / Q000502:physiology*; D016025:Bone Transplantation; D002909:Chronobiology Phenomena; D004815:Epidermal Growth Factor / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D017102:Fracture Healing / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D011506:Proteins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D011506:Proteins; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I