Is Tourette syndrome a cause of sudden infant death syndrome and childhood obstructive sleep apnea?
The cause of sudden infant death syndrome (SIDS) is unknown. Sleep-related impairment of respiratory control and arousal are postulated; hyperdopaminergic and hyposerotonergic dysfunction may contribute to events leading to infant apnea and SIDS. Psychosocial adversity and impulsive and compulsive behaviors characterize some families of SIDS victims. Tourette syndrome (TS) is a common hereditary neurobehavioral disorder characterized by the frequent presence of impulsive and compulsive behaviors. Sleep disorders are common and include sleep apnea and abnormal arousal. Hyperdopaminergic and hyposerotonergic abnormalities are postulated to contribute to the pathophysiology of the disorder. The following is a report of the presence of incidents of infant apnea and SIDS in families in which TS was present. In an additional TS family, a child had obstructive sleep apnea syndrome (OSAS). Results of a preliminary survey suggest that TS gene carriers are at increased risk of life-threatening apneas of infancy and that the prevalence of SIDS in such families may be 2 to 5 times the prevalence in the general population. The presence in some pedigrees of sleep apnea in children and adults suggest that in some instances disorders of sleep-related ventilatory control and arousal occurring throughout the life-span share common pathophysiological mechanisms.
Sverd
J
J
Sagamore Children's Psychiatric Center, Office of Mental Health, State of New York, Dix Hills 11746.
Montero
G
G
D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D015995:Prevalence; D012891:Sleep Apnea Syndromes / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D013398:Sudden Infant Death / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D005879:Tourette Syndrome / Q000150:complications* / Q000453:epidemiology / Q000235:genetics