Successful childbirth by a patient with congenital factor XI deficiency and an acquired inhibitor.
Acquired inhibitors in factor XI deficiency (FXI) are rare. The presence of an inhibitor during pregnancy poses a potential haemorrhagic risk to the fetus. We report an uncomplicated pregnancy and successful childbirth by a woman with congenital FXI deficiency and an acquired inhibitor, and discuss the persistence of residual FXI activity in the presence of an inhibitor.
Ginsberg
S S
SS
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Clyne
L P
LP
McPhedran
P
P
Duffy
T P
TP
Hanson
T
T
D000328:Adult; D002585:Cesarean Section; D005172:Factor XI / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005173:Factor XI Deficiency / Q000097:blood*; D005260:Female; D006801:Humans; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*
D005172:Factor XI