title: Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol .
abstract: The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. Following intracerebroventricular (i.c.v.) administration, N-DPB-THPO blocked tonic hindlimb extension in a dose- and time-dependent manner. At the doses tested no gross behavioral effects were noted.
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84108.
authors.forename: H S
authors.initials: HS
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Hunt
authors.forename: H H
authors.initials: HH
authors.lastname: Wolf
authors.forename: E A
authors.initials: EA
authors.lastname: Swinyard
authors.forename: E
authors.initials: E
authors.lastname: Falch
authors.forename: P
authors.initials: P
authors.lastname: Krogsgaard-Larsen
authors.forename: A
authors.initials: A
authors.lastname: Schousboe
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D018756:GABA Antagonists; D007276:Injections, Intraventricular; D007555:Isoxazoles / Q000494:pharmacology*; D051379:Mice; D012640:Seizures / Q000517:prevention & control; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D018756:GABA Antagonists; D007555:Isoxazoles; C081926:N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol; D005680:gamma-Aminobutyric Acid