title: Alfentanil in daycase anaesthesia. Assessment of a single dose on the quality of anaesthesia and recovery.
abstract: The effect of the addition of a single dose of 7 micrograms.kg-1 of alfentanil to a propofol/enflurane anaesthetic on the quality of anaesthesia and recovery was assessed. A total of 53 ASA grade 1 or 2 patients who underwent daycase dental surgery were allocated randomly to receive either alfentanil or saline. The study was blinded so that neither the anaesthetist nor the assessor was aware of which solution had been given. Patients in the alfentanil group took significantly longer to recommence spontaneous ventilation (p = 0.035). Both techniques provided good quality of anaesthesia. Postoperative morbidity was common (45% of patients), but there was no difference between the groups. The rate of recovery was similar in the two groups and no patient required hospital admission after the final assessment at 3 h. Drowsiness was only mild to moderate in both groups at 24 h. A single dose of alfentanil can be administered safely as part of a daycase anaesthetic without increasing morbidity, although there appears to be little advantage in doing so.
authors.affiliation: Department of Anaesthesia, Queen's Medical Centre, Nottingham.
authors.forename: O N
authors.initials: ON
authors.lastname: Bagshaw
authors.forename: P
authors.initials: P
authors.lastname: Singh
authors.forename: A R
authors.initials: AR
authors.lastname: Aitkenhead
mesh_terms: D000328:Adult; D015760:Alfentanil; D000556:Ambulatory Surgical Procedures; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental; D000768:Anesthesia, General; D004311:Double-Blind Method; D004737:Enflurane; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D015742:Propofol
chemical_list: D015760:Alfentanil; D004737:Enflurane; D015742:Propofol