[The capacity of Yersinia pestis toxin to decrease the functional response of human thrombocytes to stimulation by hormones].
Yersinia pestis toxin (fraction II by E. Baker) (YPT) inhibited the aggregation of human platelets as well as elevation of [Ca2+], induced by different agonists (ADP, PAF, Thrombin). Agonist-induced Ca2+ mobilization and Ca2+ influx were dose-dependently inhibited by the toxin. The effect was rapid, developing during the first minute of incubation with toxin. In contrast to murine lethal protein (MLP), the platelet-inhibiting activity was thermostable and was eliminated in the course of MLA purification from YPT. These data indicate that Yersinia pestis component, unlike MLP, could influence the Ca(2+)-dependent processes in human platelets.
Cherkasova
T D
TD
Bochkov
V N
VN
Iurkiv
V A
VA
Pokrovskiĭ
V I
VI
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001427:Bacterial Toxins / Q000302:isolation & purification / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors; D015010:Yersinia pestis
D001427:Bacterial Toxins; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D002118:Calcium
Sposobnost' toksina Yersinia pestis umen'shat' funktsional'nyĭ otvet trombotsitov cheloveka na stimuliatsiiu gormonami.