Path analysis and sib-pair linkage.
When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coefficient is developed and a method for fitting a covariance matrix predicted by a specific ordering of loci to an observed covariance matrix is proposed.
Carey
G
G
Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447.
Williamson
J A
JA
D004812:Epidemiologic Methods; D005190:Family; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D011336:Probability