[The effect of 3-mercaptopropionic acid on the toxicity of GABA-lytics for mice].
The influence of 3-mercaptopropionic acid (3-MPA) on toxicities of bicuculline and picrotoxin was evaluated in mice. It was demonstrated that 3-MPA pretreatment for 5 min increased the toxicities of bicuculline and picrotoxin by 26% and 31%, respectively. 3-MPA did not alter the binding of (3H)TBOB and (3H)GABA to synaptosomal brain membranes of intact mice. The changes in toxicity may be associated with increased binding of GABA-antagonists to their receptors due to decreased brain GABA.
Golovko
A I
AI
Sofronov
G A
GA
Kliuntina
T V
TV
D015097:3-Mercaptopropionic Acid / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000633:toxicity*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000378:metabolism; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004357:Drug Synergism; D018756:GABA Antagonists; D008024:Ligands; D008297:Male; D051379:Mice; D010852:Picrotoxin / Q000633:toxicity*; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000378:metabolism
D015097:3-Mercaptopropionic Acid; D001640:Bicuculline; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018756:GABA Antagonists; D008024:Ligands; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid; C046308:tert-butylbicyclo-2-benzoate
Vliianie 3-merkaptopropionovoĭ kisloty na toksichnost' GAMK-litikov dlia mysheĭ.