title: Invasive aspergillosis in leukemic children.
abstract: Two cases of invasive aspergillosis are reported. Case 1, a 3-year-old boy with leukemic transformation of myelodysplastic syndrome, had an aspergillus infection in the hand, resulting in necrosis of the thumb. Case 2, an 18-year-old girl with acute megakaryoblastic leukemia, had an aspergillus skin infection on the wrist, accompanied by swelling and discoloration of the arm. In Case 2, angiography revealed a hypovascular lesion and vascular irregularity, suggesting that vessels were involved. Intraarterial infusion of urokinase and amphotericin B led to improvement of these symptoms in this patient. The combination of urokinase and an antifungal drug should be considered for intractable aspergillus infections involving the extremities.
authors.affiliation: Department of Pediatrics, Gunma University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shitara
authors.forename: S
authors.initials: S
authors.lastname: Yugami
authors.forename: M
authors.initials: M
authors.lastname: Sotomatu
authors.forename: Y
authors.initials: Y
authors.lastname: Oshima
authors.forename: H
authors.initials: H
authors.lastname: Ijima
authors.forename: T
authors.initials: T
authors.lastname: Kuroume
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology*; D002675:Child, Preschool; D003881:Dermatomycoses / Q000209:etiology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications*; D008297:Male; D013927:Thrombosis / Q000209:etiology / Q000628:therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D000666:Amphotericin B; D014568:Urokinase-Type Plasminogen Activator