Effects of rhubarb tannins on renal function in rats with renal failure.
The effects of tannins purified from Rhei Rhizoma on various parameters of renal function were investigated in rats with adenine-induced renal failure. The glomerular filtration rate, renal plasma flow and renal blood flow were significantly increased in rats given (-)-epicatechin 3-O-gallate at a dose of 5 or 10 mg/kg body weight/day for 24 days. Administration of 5 mg of procyanidin B-2 3,3'-di-O-gallate also led to a significant increase in renal functional parameters. However, unlike the former two components, procyanidin C-1 3,3',3''-tri-O-gallate caused aggravation of renal function.
Yokozawa
T
T
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Fujioka
K
K
Oura
H
H
Nonaka
G
G
Nishioka
I
I
D000225:Adenine; D000818:Animals; D044946:Biflavonoids; D002392:Catechin; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D010946:Plants, Medicinal; D044945:Proanthocyanidins; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D012250:Rheum / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013634:Tannins / Q000737:chemistry / Q000494:pharmacology*
D044946:Biflavonoids; D044945:Proanthocyanidins; D013634:Tannins; C479578:procyanidin B; C479583:procyanidin C; D002392:Catechin; D000225:Adenine