Neuroleptic malignant syndrome induced by nemonapride.
A 17-year-old girl with acute schizophrenic symptoms who after the administration of 9 mg P.O. of nemonapride, developed a neuroleptic malignant syndrome, a rare but serious adverse effect of neuroleptic medication, is reported. She recovered after the administration of dantrolene. This side effect induced by nemonapride has not been reported previously. Nemonapride is a highly selective dopamine D-2 antagonist, equivalent to haloperidol. It is supposed that nemonapride can induce the neuroleptic malignant syndrome similar to haloperidol.
Kubota
T
T
Department of Neuropsychiatry, Kohritsu Mattoh Ishikawa Central Hospital, Mattoh, Japan.
D000293:Adolescent; D001549:Benzamides / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D011759:Pyrrolidines / Q000009:adverse effects*; D012559:Schizophrenia / Q000139:chemically induced
D001549:Benzamides; D011759:Pyrrolidines; C030265:nemonapride