Reduction of thyroxine-induced necrotic foci and thrombi in the mouse liver by androgen, oestrogen and glucocorticoid but not by progesterone.
Injections of thyroxine (T4) at a dose of 10 micrograms/mouse/day into castrated adult female or male C57BL/6 mice for 3 weeks induced multiple necrotic foci and portal thrombi in the liver at high incidences. However, injections of T4 into intact female or male mice resulted in the marked decrease in their incidences. Furthermore, injections of 5 alpha-dihydrotestosterone at doses more than 50 micrograms/mouse/day, oestradiol-17 beta at doses of 0.2 and 1 micrograms/mouse/day or dexamethasone at doses more than 20 micrograms/mouse/day into castrated female mice markedly reduced incidences of necrotic foci and thrombi induced by T4, while injections of progesterone did not show any effects on them. The present results indicate that an excess of thyroid hormone causes the hepatic impairment in castrated mice and that androgen and oestrogen at physiological doses, and glucocorticoid at pharmacological doses prevent it.
Yamamoto
R
R
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Oda
M
M
Yamamoto
T
T
Nishizawa
Y
Y
Tsuji
M
M
Terada
N
N
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D015994:Incidence; D007279:Injections, Subcutaneous; D008099:Liver / Q000098:blood supply / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009336:Necrosis; D011169:Portal Vein; D011374:Progesterone / Q000494:pharmacology; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy* / Q000453:epidemiology; D013974:Thyroxine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*
D012739:Gonadal Steroid Hormones; D013196:Dihydrotestosterone; D011374:Progesterone; D004958:Estradiol; D003907:Dexamethasone; D013974:Thyroxine