[Clinical and experimental study on effect of jin-qi-jiang-tang-pian on qi-yin deficiency and hyperactivity of diabetes mellitus].
The purpose of this study was to verify the effect of Jin-Qi-Jiang-Tang-Pian (JQJTP) on fasting blood glucose (FBG), postcibal blood glucose (PBG), total cholesterol (TC), triglycerides (TG), acetylcholine esterase (AchE), insulin, RBC-superoxide dismutase (RBC-SOD) and malondialdehyde (MDA). Efficacy was observed in 40 cases of diabetes mellitus, 20 cases administered with Yu-Quan Pian (YQP) were taken as control. Each group took drugs for two months. After treatment with Jin-Pi-Jiang-Tang-Pian, FBG, PBG, AchE were apparently dropped and RBC-SOD increased, as compared with patients of the YQP group (P < 0.05-0.01), and major symptoms of diabetes were improved. In experimental study, model rats suffering from diabetes induced by alloxan were observed, the rats' blood sugar level above 11.1 mmol/L were chosen for observation. These rats were divided into JQJTP group, YQP group and control group. It was found that JQJTP was able to lower blood sugar, TG and MDA (P < 0.05-0.001) significantly, with a increase of the SOD/MDA, as compared with those of patients of the control groups.
Liang
X C
XC
Peking Union Medical College Hospital, Beijing.
Xie
M Z
MZ
Guo
S S
SS
D000368:Aged; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008875:Middle Aged; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D013607:Tablets
D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D013607:Tablets; D008315:Malondialdehyde; D013482:Superoxide Dismutase