Functional significance of protein kinase C in human T-cell activation: a new therapeutic class?
The assumption that protein kinase C activation is necessary for T-cell activation in response to MHC class II restricted antigen-presentation is supported by several lines of circumstantial evidence. We have developed potent, cell-permeable and selective inhibitors of PKC to test this hypothesis. Our data demonstrate the crucial role for PKC in T-cell activation and that selective orally bioavailable PKC inhibitors are efficacious in preventing T-cell driven chronic inflammatory responses in vivo.
Hallam
T J
TJ
Roche Research Centre, Welwyn Garden City, Herts, U.K.
D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy / Q000517:prevention & control; D008213:Lymphocyte Activation / Q000502:physiology*; D008301:Maleimides / Q000494:pharmacology; D051379:Mice; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000276:immunology*; D051381:Rats; D013601:T-Lymphocytes / Q000201:enzymology* / Q000276:immunology*
D007211:Indoles; D008301:Maleimides; C071924:Ro 31-8425; D011493:Protein Kinase C