Cutaneous Nocardia farcinica infection in a nonimmunocompromised patient: case report and review.
Nocardia farcinica, the etiologic agent of bovine farcy, is microbiologically related to but distinct from Nocardia asteroides. N. farcinica is noted for its propensity to cause serious systemic infection in both normal and immunocompromised hosts and its marked degree of resistance to multiple antimicrobial agents. We present a case in which a nonimmunocompromised patient who sustained a contaminated facial laceration developed an abscess due to N. farcinica with underlying osteomyelitis. The severity of the infection necessitated surgical debridement followed by administration of intravenous amikacin therapy. The isolate was susceptible to amikacin and trimethoprim-sulfamethoxazole but resistant to erythromycin in vitro. Therapy with trimethoprim-sulfamethoxazole was started but was discontinued because of the patient's intolerance to the drug. Intramuscular amikacin was substituted, resulting in complete resolution of the infection. The history, epidemiology, and microbiological characteristics of this interesting and unusual microorganism are reviewed.
Schiff
T A
TA
Department of Dermatology, New York University Medical Center, New York 10016.
McNeil
M M
MM
Brown
J M
JM
D000038:Abscess / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology* / Q000601:surgery; D000583:Amikacin / Q000627:therapeutic use; D003646:Debridement; D004342:Drug Hypersensitivity / Q000209:etiology; D004352:Drug Resistance, Microbial; D005151:Facial Injuries / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009615:Nocardia / Q000187:drug effects / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology* / Q000601:surgery; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology* / Q000601:surgery; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects; D014946:Wound Infection / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology* / Q000601:surgery
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000583:Amikacin