[Is it possible to individualize microvillous large-cell lymphoma among sinusoid lymphomas?].
Microvillous non-hodgkin lymphomas are large cell malignant lymphomas with a sinus growth pattern and the presence of cytoplasmic processes detected by electron microscopy. Microvillous non-hodgkin lymphomas appear to be of B cell lineage. Neoplasms considered in the differential diagnosis include anaplastic large cell Ki-1 lymphomas, malignant histiocytosis and metastatic carcinoma or malignant melanoma. A panel of markers are usually sufficient to recognize all of these neoplasms except microvillous lymphomas. We report a case of microvillous non-hodgkin lymphoma characterized by a histologic pattern mimicking those of anaplastic large cell Ki-1 lymphoma. However, immunohistochemistry study failed to demonstrate presence of activation antigen such as Ki-1, EMA, interleukin 2 receptor. Ultrastructural study showed that neoplastic cells exhibited filliform cytoplasmic processes. This report raise the possibility of an overlap between microvillous non-hodgkin lymphomas and anaplastic large cell Ki-1 lymphomas of B-cell lineage. It must be emphasized that, initially, these two kinds of lymphomas were defined with different morphologic technologies.
Mosnier
J F
JF
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Beaujon, Clichy.
Molas
G
G
Gay
D
D
Loncle
T
T
Hénin
D
D
D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000556:secondary / Q000648:ultrastructure; D003937:Diagnosis, Differential; D054747:Histiocytic Sarcoma / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000648:ultrastructure*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000648:ultrastructure; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000648:ultrastructure; D008871:Microvilli / Q000473:pathology; D008875:Middle Aged
D014408:Biomarkers, Tumor
Faut-il individualiser le lymphome à grandes cellules microvilleuses parmi les lymphomes intrasinusaux?