title: Effects of low-frequency magnetic fields on fetal development in rats.
abstract: We studied effects of alternating magnetic fields on the embryonic and fetal development of rats. Mated females of the Han:Wistar-strain were sham exposed or exposed continuously to a 50-Hz field or to a 20,000 pulse-per-second (pps) sawtooth magnetic field from day 0 to day 20 of pregnancy for 24 h/day until necropsied on day 20. The respective peak-to-peak intensities of the fields were 35.6 microT (sinewave) and 15.0 microT (sawtooth). Each treatment group contained 72 bred females. Control animals were kept under the same conditions without the magnetic field. No adverse effects were seen in the dams. The mean numbers of implantations and living fetuses per litter were statistically significantly increased in the 50-Hz group. There were, however, three total resorptions of litters in dams of the control group, which contributed to the difference in the number of living fetuses. The corrected body-mass gains (gains without uterine content) of dams were similar in all groups. Pregnancy rates, incidences of resorptions, late fetal deaths, and fetal body masses were similar in all groups. The incidence of fetuses with minor skeletal anomalies was statistically significantly increased in both exposed groups. Only one serious malformation (anophthalmia, sawtooth-exposed group) and a few minor visceral malformations were found. In conclusion, the magnetic fields used in this study did not increase the incidence of major malformations or resorptions in Wistar rats. The increased number of skeletal anomalies and implantations we observed indicates, however, that some developmental effects in rats may attend exposure to time-varying magnetic fields.
authors.affiliation: National Public Health Institute, Department of Toxicology, University of Kuopio, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Huuskonen
authors.forename: J
authors.initials: J
authors.lastname: Juutilainen
authors.forename: H
authors.initials: H
authors.lastname: Komulainen
mesh_terms: D000016:Abnormalities, Radiation-Induced; D000818:Animals; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005327:Fetal Resorption / Q000209:etiology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar