Polycythemia associated with primary systemic amyloidosis: elevated levels of hemopoietic factors and cytokines.
A 60-year-old man was diagnosed to have primary systemic amyloidosis (AL type) and polycythemia (Hgb 19.1 g/dl, WBC 14,600/microliters, and platelets 60.5 x 10(4)/microliters). In vitro colony assay for hemopoietic stem cells showed increased numbers of colony-forming units (CFU)-G, CFU-GM, CFU-E, and CFU-Meg. Serum levels of erythropoietin (Epo), granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-3 and IL-6 were elevated. The infiltration of amyloid fibrils into the hemopoietic factor-producing tissues may stimulate abnormal secretion of hemopoietic factors and cytokines, resulting in increased numbers of hemopoietic stem cells and polycythemia in the peripheral blood.
Nagasawa
T
T
Division of Hematology, University of Tsukuba, Ibaraki, Japan.
Yanagisawa
H
H
Hasegawa
Y
Y
Kanma
H
H
Abe
T
T
D000686:Amyloidosis / Q000097:blood* / Q000150:complications* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D003115:Colony-Stimulating Factors / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004921:Erythropoietin / Q000097:blood; D016298:Hematopoietic Cell Growth Factors / Q000097:blood*; D006801:Humans; D007377:Interleukin-3 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011086:Polycythemia / Q000097:blood* / Q000150:complications* / Q000473:pathology; D012016:Reference Values
D003115:Colony-Stimulating Factors; D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors; D007377:Interleukin-3; D015850:Interleukin-6; D004921:Erythropoietin