title: [Determination of fibrinogen content in human blood plasma using thrombin-like enzyme of ancistron N and analysis of hemostasis under presence of blood coagulation inhibitors].
abstract: The cases of non-coagulation or only partial coagulation of blood plasma fibrinogen under the effect of thrombin have been revealed while examining the homeostasis-state in practically healthy elderly and old people and those with hypertonic disease. These cases have been analyzed. It is shown that the suggested method of fibrinogen determination in blood plasma using thrombin-like enzyme ancistrone-H extracted from venom of snakes (Agkistrodon halys halys) permits determining the fibrinogen content in blood plasma even in the cases connected with the presence of circulating coagulation inhibitors in plasma. The determination is not hindered by the introduction of exogenous heparin, including low-molecular heparins of the fraxiparin type.
authors.forename: T N
authors.initials: TN
authors.lastname: Platonova
authors.forename: O O
authors.initials: OO
authors.lastname: Sushko
authors.forename: D O
authors.initials: DO
authors.lastname: Colovĭov
authors.forename: Ia M
authors.initials: IaM
authors.lastname: Iena
mesh_terms: D000368:Aged; D001780:Blood Coagulation Tests; D003435:Crotalid Venoms; D005340:Fibrinogen / Q000032:analysis*; D006487:Hemostasis; D006801:Humans; D006973:Hypertension / Q000097:blood*; D012697:Serine Endopeptidases
chemical_list: D003435:Crotalid Venoms; D005340:Fibrinogen; D012697:Serine Endopeptidases; C063190:ancistron N
vernacular_title: Vyznachennia vmistu fibrynogenu v plazmi krovi liudyny za dopomogoiu trombinopodibnogo fermentu antsystronu-H ta analiz stanu gemostazu pry naiavnosti ingibitoriv zsidannia krovi.