title: Phase II study of goserelin for patients with postmenopausal metastatic breast cancer.
abstract: OBJECTIVE
  To determine the response rate of postmenopausal breast cancer patients to the gonadotropin-releasing hormone (GN-RH) agonist, Zoladex (goserelin; ICI Pharma, Wilmington, DE).
  
  
  METHODS
  A multi-institutional single-agent trial in postmenopausal patients was conducted. Serum levels of follicle-stimulating hormone (FSH), testosterone, and estradiol were requested before and after Zoladex treatment.
  
  
  RESULTS
  For estrogen receptor-positive (ER+) patients, the response rate was 11%, with one complete response (CR) and three partial responses (PRs) among 36 eligible patients. Responses were of short duration. There were no responses among 16 estrogen receptor-negative (ER-) patients.
  
  
  CONCLUSIONS
  GN-RH agonists have activity in ER+ postmenopausal patients, but response rates are not as high as with other available endocrine therapies and the duration of response is short.
authors.affiliation: University of Wisconsin Comprehensive Cancer Center, Madison.
authors.forename: T
authors.initials: T
authors.lastname: Saphner
authors.forename: A B
authors.initials: AB
authors.lastname: Troxel
authors.forename: D C
authors.initials: DC
authors.lastname: Tormey
authors.forename: D
authors.initials: D
authors.lastname: Neuberg
authors.forename: N J
authors.initials: NJ
authors.lastname: Robert
authors.forename: K J
authors.initials: KJ
authors.lastname: Pandya
authors.forename: J H
authors.initials: JH
authors.lastname: Edmonson
authors.forename: R J
authors.initials: RJ
authors.lastname: Rosenbluth
authors.forename: M D
authors.initials: MD
authors.lastname: Abeloff
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood; D017273:Goserelin / Q000627:therapeutic use*; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011960:Receptors, Estrogen / Q000378:metabolism; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D012739:Gonadal Steroid Hormones; D011960:Receptors, Estrogen; D017273:Goserelin; D005640:Follicle Stimulating Hormone