title: Renal effects of naphtha exposure among automotive workers.
abstract: As part of a study on health effects of naphtha exposure, the association between naphtha exposure and urinary excretion of total protein, albumin, beta-N-acetyl-D-glucosaminidase (beta-NAG), and beta 2-microglobulin was assessed prospectively over 1 year among workers at an automotive plant that used naphtha to calibrate fuel injectors. Participants consisted of 248 workers who provided spot urine samples in June 1988 among whom 181 workers provided specimens again in June 1989. Naphtha air concentrations at the plant ranged from 6 to 790 mg/m3 and the length of exposure ranged from 0.8 to 7.3 years. In both 1988 and 1989, the overall distribution of the four measures of renal function appeared consistent with that of an unexposed population. In cross-sectional analyses, there were no statistically significant associations in the expected direction between cumulative or recent naphtha exposure and the measures of renal function. In longitudinal analyses, the change in beta-NAG was positively associated with the change in recent naphtha exposure (P = .009). The effect of the naphtha exposure during 1 workweek was assessed among 17 workers who provided urine samples Monday preshift, Monday postshift, and Friday postshift. No associations were found. The results of this study do not provide strong evidence of naphtha-associated renal effects at these levels of exposure.
authors.affiliation: Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor 48109.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Rocskay
authors.forename: T G
authors.initials: TG
authors.lastname: Robins
authors.forename: M A
authors.initials: MA
authors.lastname: Schork
authors.forename: D
authors.initials: D
authors.lastname: Echeverria
authors.forename: S P
authors.initials: SP
authors.lastname: Proctor
authors.forename: R F
authors.initials: RF
authors.lastname: White
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000419:Albuminuria / Q000139:chemically induced* / Q000175:diagnosis; D000473:Alkanes / Q000009:adverse effects*; D001336:Automobiles; D005260:Female; D006801:Humans; D007221:Industry; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000175:diagnosis; D007677:Kidney Function Tests; D008297:Male; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D016273:Occupational Exposure / Q000009:adverse effects*; D011446:Prospective Studies; D011507:Proteinuria / Q000139:chemically induced / Q000175:diagnosis; D012307:Risk Factors
chemical_list: D000395:Air Pollutants, Occupational; D000473:Alkanes; C004544:naphtha