[Renal structure and function in experimental diabetic rats following unilateral nephrectomy].
Renal structure and function in 50 streptozotocin-induced diabetic rats having unilateral nephrectomy and the effect of captopril treatment were observed for 3 months. The glomerular filtration rate, renal plasma flow, KW/BW, mean glomerular volume, wide glomerular basement membrane, glomerular mesangial cell proliferation as well as the ratio of 6-keto-PGF1 alpha/TXB2 of kidney tissue in the diabetic rats were significantly increased than those in the non-diabetic rats. These indexes were not significantly different between groups with and without captopril treatment. The results mentioned above illustrated that the obvious renal injury in diabetic rats receiving unilateral nephrectomy could be found as early as in the 3rd month of the experiment. These changes might be related to the metabolic abnormality of glucose and prostaglandins in the kidney and no effect of low dose captopril were noted on the renal injury.
Liu
Z
Z
Department of Endocrinology, PLA General Hospital, Beijing.
D000818:Animals; D002216:Captopril / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005919:Glomerular Filtration Rate; D007328:Insulin / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D002216:Captopril