[The effect of peptide-type epiphyseal hormones on the functional activity of the human thyroid in vitro. The characteristics of the action of epiphyseal peptides on the accumulation of cyclic nucleotides in the thyrotoxic thyroid and on its secretory activity].
Reaction of the human TSH-sensitive and TSH-refractory thyroid, obtained from patients with hyperthyroidism, on pineal peptides was studied in vitro. It was shown, that pineal peptides (Epythalamine) are inhibitors of cAMP accumulation and hormone release only of normal and TSH-sensitive thyroid, but are ineffective in case of TSH-refractory thyroid. Thus, pineal peptides are modulators of specific TSH effect.
Rom-Bugoslavskaia
E S
ES
Gal'chinskaia
V Iu
VIu
Komarova
I V
IV
D000818:Animals; D002417:Cattle; D046508:Culture Techniques; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013971:Thyrotoxicosis / Q000503:physiopathology*; D013972:Thyrotropin / Q000494:pharmacology
D006728:Hormones; D009712:Nucleotides, Cyclic; D010455:Peptides; C027437:epithalamin; D013972:Thyrotropin
Vliianie épifizarnykh gormonov peptidnoĭ prirody na funktsional'nuiu aktivnost' shchitovidnoĭ zhelezy cheloveka v usloviiakh in vitro. Osobennosti vozdeĭstviia épifizarnykh peptidov na akkumuliatsiiu tsiklicheskikh nukleotidov v tireotoksicheskoĭ shchitovidnoĭ zheleze i ee sekretornuiu aktivnost'.