Lack of evidence for maternal effect in familial Alzheimer's disease.
Mitochondrial defects may be involved in Alzheimer's disease (AD) by lowering the oxidative phosphorylation efficiency at an earlier age. To investigate the possible contribution of an inherited mitochondrial DNA defect to familial AD (FAD), we examined the Genetic Analysis Workshop (GAW) data for evidence of maternal transmission and the effect on the age of onset. We found no evidence in support of inherited mitochondrial defects in the GAW FAD kindreds.
Payami
H
H
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201-3098.
Hoffbuhr
K
K
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001900:Boston / Q000453:epidemiology; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers; D009154:Mutation; D009657:North Carolina / Q000453:epidemiology; D014861:Washington / Q000453:epidemiology
D004272:DNA, Mitochondrial