title: Retinal cone dysfunction of supernormal rod ERG type. Five new cases.
abstract: Five patients, not related to each other, showed clinical signs, including electroretinograms, of a retinal dysfunction which mainly affected the cone system, but also involved the rod responses in a peculiar way. ERG b-wave threshold under dark adapted conditions was elevated. In contrast, rod b-wave sensitivity was enhanced with medium to high intensity flash stimulation. Furthermore, all patients had a severe reduction of the oscillatory potentials. The findings are discussed with special emphasis on a hypothetical disturbance in the cyclic guanosine monophosphate metabolism, involving both photoreceptors and cells of the inner plexiform layer responsible for retinal feedback mechanisms.
authors.affiliation: National Eye Clinic for The Visually Impaired, Hellerup, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Rosenberg
authors.forename: S E
authors.initials: SE
authors.lastname: Simonsen
mesh_terms: D000328:Adult; D002648:Child; D003623:Dark Adaptation; D004596:Electroretinography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009991:Oscillometry; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000503:physiopathology*; D012164:Retinal Diseases / Q000503:physiopathology*; D012684:Sensory Thresholds