title: Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?
abstract: Tamoxifen and 4-hydroxytamoxifen protect isolated human low-density lipoproteins (LDLs) against copper-ion-dependent lipid peroxidation: 4-hydroxytamoxifen is more protective than tamoxifen or 17 beta-oestradiol. 4-Hydroxytamoxifen and 17 beta-oestradiol also prevent the increase in the electrophoretic mobility of LDL caused by exposure to copper ions, presumably by protection of the apoprotein B of LDL against oxidative modification. Our observations may help to account for the cardioprotective benefits reported to be associated with tamoxifen therapy and prophylaxis in breast cancer.
authors.affiliation: Pharmacology Group, King's College, University of London, U.K.
authors.forename: H
authors.initials: H
authors.lastname: Wiseman
authors.forename: G
authors.initials: G
authors.lastname: Paganga
authors.forename: C
authors.initials: C
authors.lastname: Rice-Evans
authors.forename: B
authors.initials: B
authors.lastname: Halliwell
mesh_terms: D003300:Copper / Q000494:pharmacology*; D004587:Electrophoresis, Agar Gel; D004958:Estradiol / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000187:drug effects / Q000302:isolation & purification; D008970:Molecular Weight; D010084:Oxidation-Reduction; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D008077:Lipoproteins, LDL; D013629:Tamoxifen; C016601:afimoxifene; D004958:Estradiol; D003300:Copper