[The effect of malonic acid on the rate of fibroblast proliferation in culture].
The influence of malonic acid on the proliferation rate of cultured human fetal [correction of embryo] skin fibroblasts was investigated. Addition of malonate to the serum-less incubation mixture stimulated fibroblast proliferation. The maximum stimulation occurred in the medium at the 0.01 mM concentration of malonic acid. When the cells were cultured in the medium with serum, the influence of malonate on the cells proliferation increased.
Davydov
V V
VV
Freĭdin
M I
MI
D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D003470:Culture Media; D016895:Culture Media, Serum-Free; D004305:Dose-Response Relationship, Drug; D005333:Fetus; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008314:Malonates / Q000494:pharmacology*; D012867:Skin / Q000166:cytology
D003470:Culture Media; D016895:Culture Media, Serum-Free; D008314:Malonates; C030290:malonic acid
Vliianie malonovoĭ kisloty na skorost' proliferatsii fibroblastov v kul'ture.