title: [Endotoxemia in severely burned patients].
abstract: Plasma endotoxin was determined by modified synthetic chromogenic limulus amebocyte lysate assay in 35 severely burned patients (30% to 98% TBSA). The results showed that the level of circulating endotoxin markedly increased during the early stage after injury, with a peak value at the 3rd postburn days. The relationship between burn size and the endotoxin value was significant (P < 0.01); The incidence of endotoxemia in the 35 patients was 36.8% to 74.7%. The plasma endotoxin concentrations of 7 burned patients with multiple system organ failure (MSOF) raced from 0.512 to 1.127 EU/ml, significantly higher than those of 10 patients without MSOF (0.216-0.553 EU/ml) at 3, 14, 21 and 28 postburn days. Endotoxemia in severely burned patients commonly occurred and was closely related to the development of sepsis and MSOF after burn injury. Dynamic observation of the changes in circulating endotoxin concentration was valuable as a marker for predicting sepsis and MSOF in critically ill patients with burns.
authors.affiliation: Trauma Center, Postgraduate Medical College, 304 Hospital of People's Liberation Army, Beijing.
authors.forename: Y M
authors.initials: YM
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000150:complications / Q000382:microbiology*; D002648:Child; D004731:Endotoxins / Q000097:blood*; D004926:Escherichia coli; D005260:Female; D006801:Humans; D008033:Limulus Test; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology*; D011550:Pseudomonas aeruginosa
chemical_list: D004731:Endotoxins