title: Does decreased skeletal uptake of 99mTc-methylene bisphosphonate in irradiated bone indicate the absence of bone metastases?
abstract: Reduced uptake of 99mTc-methylene bisphosphonate (99mTc-MBP) was found in irradiated bone in all of 13 tumour-free patients who had undergone radiotherapy (30-40 Gy) due to seminoma 3-8 years prior to bone scintigraphy. Decreased uptake of 99mTc phosphate compounds can not per se be interpreted as a sign of absence of metastases or reduced tumour burden.
authors.affiliation: Department of Medical Oncology, Norwegian Radium Hospital, Oslo.
authors.forename: S D
authors.initials: SD
authors.lastname: Fosså
authors.forename: M
authors.initials: M
authors.lastname: Winderen
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000528:radiation effects; D000328:Adult; D001011:Aorta; D004407:Dysgerminoma / Q000532:radiotherapy*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000528:radiation effects*; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000378:metabolism / Q000528:radiation effects; D008875:Middle Aged; D011877:Radionuclide Imaging; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000528:radiation effects*
chemical_list: D013669:Technetium Tc 99m Medronate