title: Detecting heterogeneity with the affected-pedigree-member (APM) method.
abstract: We have developed a novel test of heterogeneity based on the APM method. We present tests of this method on both empiric and simulated data.
authors.affiliation: Department of Human Genetics, University of Pittsburgh, PA 15261.
authors.forename: T C
authors.initials: TC
authors.lastname: Matise
authors.forename: D E
authors.initials: DE
authors.lastname: Weeks
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001900:Boston / Q000453:epidemiology; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D010375:Pedigree; D013223:Statistics as Topic / Q000379:methods
chemical_list: D005819:Genetic Markers