[Feasibility of establishing genetic homeostasis in human populations using a complex of genetic markers].
The information that we have about functional connection of different phenotypes of independent loci served for identification of their reciprocal behavior in cohorts differed in healthy status from the same population. Coefficients of correlation were computed between phenotypes according to the scheme: everyone with all in a Buryat, on the basis of the distribution of 17 genetic loci. Their space was transformed to a standardized one of eigenvectors. Calculation of the distances between genotypes was performed using the Euclidean formula. The same distances were estimated using an alternative formula of reverse cosine from correlation. It was determined: 1) subgroups of ecological risk and adaptive norm have peculiarities of phenotypical combinations; 2) the number of reliable correlations between phenotypes 2.5 times exceeded that in the adaptive part of the population as compared with unfavourable cohort (according to the health status); 3) the proportion of attractably connected phenotypes (the effect of their interaction) was higher than the corresponding repulsive connected ones (the effect of their repulsion) in the adaptive standard subgroup; 4) on the contrary, the proportion of repulsively connected phenotypes prevailed over the corresponding attractably associated ones in the ecological risk subgroup; 5) there were smaller genetic distances between phenotypes in the adaptive norm subgroup as compared with those in the ecological risk cohort. All these data permit to narrate about considerably greater functional balance of the studied portion of the genome in the clinically healthy subgroups that express the display of genetic homeostasis in complex discrete nonlinked characters. Interloci correlation between Hp and Cerumen systems in the three populations studied were obtained.
Agapova
R K
RK
Spitsyn
V A
VA
Novoradovskiĭ
A G
AG
D000222:Adaptation, Physiological; D002874:Chromosome Mapping; D005819:Genetic Markers; D005828:Genetics, Population; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008433:Mathematics; D010641:Phenotype; D012307:Risk Factors; D012426:Russia
D005819:Genetic Markers
Vozmozhnost' ustanovleniia geneticheskogo gomeostaza v populiatsiiakh cheloveka po kompleksu markerov genov.