Atopic ocular disease.
Atopy arises from a complex interplay between immunogenetic controls and complex environmental allergens. Family studies of atopic patients indicate a polygenic control of IgE production overlayed with exposure to certain ubiquitous environmental antigens. Ultrapurified antigen studies in families indicate that HLA-D immune response genes, notably HLA-DR/Dw2, are implicated in some atopic responses. IgE-binding factors and gene regulation of proteins controlling glycosylation of them also influence the serum levels of IgE, as do the levels of at least two cytokines, IL-4 and gamma interferon.
Barney
N P
NP
Foster
C S
CS
D000485:Allergens; D003233:Conjunctivitis, Allergic / Q000235:genetics* / Q000276:immunology; D005802:Genes, MHC Class II / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000235:genetics
D000485:Allergens; D006684:HLA-DR Antigens; D007073:Immunoglobulin E