Influence of ketorolac tromethamine on clot elastic strength in humans as assessed by thromboelastography.
OBJECTIVE
To evaluate the effect of ketorolac tromethamine on coagulation using thromboelastography (TEG).


METHODS
TEGs were performed in each patient before and after ketorolac administration. Each patient's predrug results were used as control measurements for comparison with the postdrug results.


METHODS
Medical center surgical unit.


METHODS
Twenty ASA physical status I and II patients undergoing minor elective surgery; 12 healthy volunteers.


METHODS
TEGs were performed in all subjects before and 60 minutes after the intramuscular (IM) administration of ketorolac tromethamine 60 mg. Ten surgical patients were studied in the intraoperative period, and 10 surgical patients were studied in the postoperative period. The 12 healthy volunteers did not undergo a surgical procedure.


RESULTS
Specific parameters assessed from the TEGs were reaction time (R time), coagulation time (RK time), clot formation rate (angle of deflection), and maximum clot strength (maximum amplitude of deflection). Ketorolac administration did not cause statistically significant changes in these parameters in any of the three groups studied.


CONCLUSIONS
IM administration of ketorolac tromethamine 60 mg did not significantly alter the speed of formation or viscoelastic strength of clots as measured by TEG. These results provide additional support for prior clinical studies confirming the safety of ketorolac administration in the perioperative period.
Reinhart
D J
DJ
Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas.
Latson
T W
TW
Whitten
C W
CW
Klein
K W
KW
Allison
P M
PM
Patel
M
M
D000328:Adult; D000700:Analgesics / Q000097:blood / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004338:Drug Combinations; D004548:Elasticity; D004724:Endoscopy; D005260:Female; D006801:Humans; D020911:Ketorolac Tromethamine; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009300:Nasal Septum / Q000601:surgery; D009666:Nose / Q000473:pathology; D011182:Postoperative Care; D013916:Thrombelastography; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D014325:Tromethamine / Q000494:pharmacology*; D014914:Whole Blood Coagulation Time
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin