title: Exogenous neuropeptide Y blocks myoelectric activity in the upper gastrointestinal tract of starved dogs. Brain neuropeptide Y converts a fasting pattern of myoelectric activity to a fed pattern.
abstract: The effect of intracerebroventricular (ICV) neuropeptide Y (NPY) on the migrating motor complex (MMC) was examined in five starved dogs. Myoelectric activity was recorded using gastric, duodenal, and jejunal electrodes. Intragastric pressure was monitored via a gastric fistula, and ICV injections were given through a cerebroventricular guide. Recordings were made with no ICV injection and before and after 250-microliters bolus injections of vehicle as control (0.1% dog serum albumin in saline) or 500 pmol/kg NPY. The mean interval between MMCs was 98 +/- 10 min without ICV injection and 96 +/- 7 min after control solution. After ICV injection of NPY no further MMCs were recorded in any dog, even though the study was continued for a minimum of 3.5 h. Instead, the myoelectric pattern became indistinguishable from that in fed dogs. We conclude that central NPY plays a role in modulation of upper gastrointestinal myoelectric activity. This may reflect a central regulatory role for NPY in the coordination of feeding.
authors.affiliation: Division of Gastrointestinal Surgery, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: H J
authors.initials: HJ
authors.lastname: Thomson
authors.forename: J G
authors.initials: JG
authors.lastname: Geoghegan
authors.forename: M
authors.initials: M
authors.lastname: Farouk
authors.forename: L A
authors.initials: LA
authors.lastname: Saperstein
authors.forename: K
authors.initials: K
authors.lastname: Chung
authors.forename: W C
authors.initials: WC
authors.lastname: Meyers
authors.forename: T N
authors.initials: TN
authors.lastname: Pappas
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D004285:Dogs; D005215:Fasting / Q000502:physiology*; D005260:Female; D005502:Food; D005769:Gastrointestinal Motility / Q000502:physiology*; D007276:Injections, Intraventricular; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D013997:Time Factors
chemical_list: D009478:Neuropeptide Y