Linkage analysis of a complex disease: application to familial Alzheimer's disease.
Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 21 was assessed using single-locus and two-locus models of inheritance. Families were divided into groups determined by their average age at onset. The youngest group produced higher lod scores for markers on chromosome 21 while an older group showed evidence for linkage to markers on chromosome 19. Two-locus models of disease were used to analyze the youngest group for linkage to pairs of markers on chromosome 21 and an older group with markers on chromosome 19.
Neuman
R J
RJ
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110-1093.
Rice
J P
JP
Hampe
C L
CL
Burroughs
T E
TE
Moldin
S O
SO
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D008957:Models, Genetic
D005819:Genetic Markers