title: Effects of rhubarb tannins on renal function in rats with renal failure.
abstract: The effects of tannins purified from Rhei Rhizoma on various parameters of renal function were investigated in rats with adenine-induced renal failure. The glomerular filtration rate, renal plasma flow and renal blood flow were significantly increased in rats given (-)-epicatechin 3-O-gallate at a dose of 5 or 10 mg/kg body weight/day for 24 days. Administration of 5 mg of procyanidin B-2 3,3'-di-O-gallate also led to a significant increase in renal functional parameters. However, unlike the former two components, procyanidin C-1 3,3',3''-tri-O-gallate caused aggravation of renal function.
authors.affiliation: Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yokozawa
authors.forename: K
authors.initials: K
authors.lastname: Fujioka
authors.forename: H
authors.initials: H
authors.lastname: Oura
authors.forename: G
authors.initials: G
authors.lastname: Nonaka
authors.forename: I
authors.initials: I
authors.lastname: Nishioka
mesh_terms: D000225:Adenine; D000818:Animals; D044946:Biflavonoids; D002392:Catechin; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D010946:Plants, Medicinal; D044945:Proanthocyanidins; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D012250:Rheum / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013634:Tannins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D044946:Biflavonoids; D044945:Proanthocyanidins; D013634:Tannins; C479578:procyanidin B; C479583:procyanidin C; D002392:Catechin; D000225:Adenine