Localization of four human serum amyloid A (SAA) protein superfamily genes to chromosome 11p: characterization of a fifth SAA-related gene sequence.
The serum amyloid A proteins (SAAs) are heterogeneous differentially expressed apolipoproteins of M(r) 12-19 kDa. Four SAA loci have been described. Two of the loci (SAA1 and SAA2) encode acute-phase SAAs (A-SAAs), which exhibit a dramatic transient increase in serum concentration in response to inflammatory stimuli; a third locus (SAA3) defines a pseudogene; and a fourth locus (SAA4) encodes a constitutively expressed SAA (C-SAA). Using locus-specific polymerase chain reaction, we have definitively assigned all four well-characterized SAA loci, SAA1, -2, -3, and -4, to chromosome 11p. In addition, we have more fully characterized an ill-defined sequence previously misidentified by others as SAA4, which also maps to chromosome 11p and may represent a fifth SAA locus.
Sellar
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Department of Genetics, Trinity College, Dublin, Ireland.
Whitehead
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AS
D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D016133:Polymerase Chain Reaction; D000685:Serum Amyloid A Protein / Q000235:genetics*
D000685:Serum Amyloid A Protein; D004247:DNA