A comparison of serotonin (5-HT) blood levels and activity of 5-HT2 antagonists in adjuvant arthritic Lewis and Wistar rats.
The total plasma 5-HT levels of adjuvant arthritic rats were increased in animals of both strains in comparison to healthy controls. The exception was day 1, when the 5-HT plasma level in arthritic Lewis rats was decreased by 77%, but only by 17% in Wistar rats. Treatment with the 5-HT2 receptor antagonist ritanserin caused a significant inhibition of macroscopic arthritis at day 14 in Lewis but not in Wistar rats. The total plasma 5-HT level was significantly decreased by the 5-HT2 antagonists in both strains at various times. 5-HT as an autacoid with effects on the T-lymphocytes and on delayed hypersensitivity reactions might be responsible, at least in part, for strain differences regarding the incidence of secondary lesions in rat adjuvant arthritis.
Pertsch
M
M
Institut Pharmakologie, Fachbereich Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Deutschland.
Krause
E
E
Hirschelmann
R
R
D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D004198:Disease Susceptibility; D005260:Female; D007650:Ketanserin / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D016713:Ritanserin / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood*; D013045:Species Specificity
D016713:Ritanserin; D012701:Serotonin; D007650:Ketanserin