title: Rhabdomyolysis and acute renal failure in a patient with hypothyroidism.
abstract: A 61-year-old woman developed rhabdomyolysis and acute renal failure after strenuous walking. She had been treated for seven years with levothyroxine (T4) for hypothyroidism. On admission, her thyroid function test revealed marked hypothyroidism, suggesting poor drug compliance. Electromyographic and muscle biopsy findings were compatible with hypothyroid myopathy. Other diseases that could cause rhabdomyolysis were excluded. Her renal function completely recovered with peritoneal dialysis, and thyroid function normalized with 100 micrograms/day of T4. The present case suggests that rhabdomyolysis could occur in patients with hypothyroidism, especially those with poor drug compliance, in combination with other aggravating factors such as exercise.
authors.affiliation: Division of Endocrinology and Metabolism, Kantoh Central Hospital, Tokyo.
authors.forename: N
authors.initials: N
authors.lastname: Sekine
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Michikawa
authors.forename: T
authors.initials: T
authors.lastname: Enomoto
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: E
authors.initials: E
authors.lastname: Ozawa
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D010349:Patient Compliance; D010530:Peritoneal Dialysis; D005082:Physical Exertion; D012206:Rhabdomyolysis / Q000150:complications / Q000209:etiology*; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine