Segmental tubular sodium reabsorption in type 1 diabetes.
Segmental tubular sodium reabsorption in Type 1 (insulin-dependent) diabetes was measured in 36 patients in a cross-sectional study including one group (n = 13) without significant albuminuria (UalbV < 30 mg 24 h-1), one group (n = 16) with albuminuria in the range from 30 to 300 mg 24 h-1, and a group (n = 7) with nephropathy (UalbV > 300 mg 24 h-1). Lithium clearance was used to measure end proximal delivery. From end proximal delivery, 51Cr-EDTA clearance (GFR) and sodium clearance, segmental tubular reabsorption was calculated. For all patients, GFR was directly correlated with end proximal delivery (r = 0.62, p < 0.0005), while end proximal delivery was inversely correlated to fractional proximal reabsorption (r = -0.71, p < 0.0005). In the subgroup with UalbV less than 30 mg 24 h-1, the direct correlation between GFR and end proximal delivery was also significant (r = 0.77, p < 0.05). In the group with nephropathy (UalbV > 300 mg 24 h-1), mean GFR and end proximal delivery were decreased and fractional proximal reabsorption was increased, but there was still a positive correlation between GFR and end proximal delivery (r = 0.75, p < 0.05) and an inverse correlation between end proximal delivery and fractional proximal reabsorption (r = -0.85, p < 0.05). It is concluded that in these groups of diabetic patients the end proximal delivery is increased while GFR is increased.(ABSTRACT TRUNCATED AT 250 WORDS)
Dieperink
H
H
Laboratory of Nephropathology, Odense University Hospital, Denmark.
Eshøj
O
O
Leyssac
P P
PP
Feldt-Rasmussen
B
B
D000328:Adult; D000419:Albuminuria; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000652:urine; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D012964:Sodium / Q000378:metabolism*
D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D012964:Sodium