[Immunoglobulin deposition in skeletal muscle in polymyositis and dermatomyositis].
An immunohistochemical study was conducted using the biotin avidin technique in 22 muscle specimens from PM/DM patients and 19 control subjects. Deposition of IgG, IgM or C3 in the wall of capillaries and small vessels was demonstrated in 72.7% of PM/DM patients and in 31.6% of those with other neuromuscular disorders. This finding supports the contention that immunoglobulins and complement-mediated immunoreaction may play an important role in PM/DM pathogenesis.
Chen
L
L
PUMC Hospital, Beijing.
Guo
Y
Y
D003176:Complement C3 / Q000378:metabolism; D003882:Dermatomyositis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D009132:Muscles / Q000276:immunology*; D017285:Polymyositis / Q000276:immunology*
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M