Use of the regressive models in linkage analysis of quantitative traits.
Use of the regressive models to account for residual familial correlations in linkage analysis of complex quantitative traits can increase the power to detect linkage. This is especially observed when the effect of the gene to be mapped is small or when the residual correlations are substantial.
Demenais
F
F
Unité de Recherche de Génétique des Maladies Humaines (INSERM U.358), Centre d'Etude du Polymorphisme Humain, Paris, France.
Lathrop
M
M
D002874:Chromosome Mapping; D003198:Computer Simulation; D030342:Genetic Diseases, Inborn / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D009010:Monte Carlo Method