title: A linkage map of human chromosome 21:43 PCR markers at average intervals of 2.5 cM.
abstract: A genetic linkage map of human chromosome 21q (HC21q) containing 43 markers genotyped by the polymerase chain reaction in the CEPH pedigrees is presented. The markers placed on this map are highly polymorphic with an average heterozygosity of 61%. The average interval size of the markers localized at 1000:1 odds is 2.5 cM. The map has a total length of 65.5 cM, with male and female lengths of 47.7 and 83.3 cM, respectively. The genotypes used in the construction of this map were subjected to rigorous error checking, which is reflected in the shorter map length compared to previous maps; the estimated error rate in genotyping is less than 0.04%. As noted in previous linkage maps there is increased recombination in females on proximal HC 21q and in the male in a region near the telomere. This map of HC 21 represents a highly informative and dense meiotic linkage map and will be useful in linking disease phenotypes to loci on this chromosome.
authors.affiliation: Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914.
authors.forename: M G
authors.initials: MG
authors.lastname: McInnis
authors.forename: A
authors.initials: A
authors.lastname: Chakravarti
authors.forename: J
authors.initials: J
authors.lastname: Blaschak
authors.forename: M B
authors.initials: MB
authors.lastname: Petersen
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: D
authors.initials: D
authors.lastname: Avramopoulos
authors.forename: J L
authors.initials: JL
authors.lastname: Blouin
authors.forename: U
authors.initials: U
authors.lastname: König
authors.forename: C
authors.initials: C
authors.lastname: Brahe
authors.forename: T C
authors.initials: TC
authors.lastname: Matise
mesh_terms: D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D012727:Sex Characteristics
chemical_list: D005819:Genetic Markers