The effect of long-term ingestion of glucocorticoids on liver and serum plasma in rats.
The effect of chronic hydrocortisone administration (0.5 mg/kg) on the liver and plasma lipid content was assessed in Wistar rats. It was found after that the liver cholesterol content was significantly increased 6 months of hydrocortisone treatment. At the same time, the distribution of liver phospholipid fractions was altered. The fatty acid composition of liver lipids showed a significant increase of 22:6 n-3. Decreased levels of cholesterol and LDL-cholesterol were found in the plasma of the hydrocortisone-treated rats.
Petrovic
G
G
Institute for Medical Research, Belgrade, Serbia.
Ristic
V
V
Vrbaski
S
S
Ristic
M
M
Suzic
S
S
D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D005227:Fatty Acids; D008055:Lipids; D008077:Lipoproteins, LDL; D010743:Phospholipids; D002784:Cholesterol; D006854:Hydrocortisone