[The adrenergic mechanisms controlling the proliferation and differentiation of hematopoietic precursor cells under immobilization stress].
The role of adrenergic structures in mechanisms of erythro- and granulomonocytopoiesis precursor cell proliferation and differentiation under immobilization stress was antagonist administration inhibited stress-induced rise of erythroid, erythrogranulocyte and granulocyte hemopoietic islets erythrogranulocyte and granulocyte hemopoietic islets forming in the bone marrow. In vitro the alpha-adrenergic agonist had a direct activating effect on CFU-GM but on CFU-E growth in normal state (10(-5) M) and after immobilization (10(-9), 10(-7) M). At the same time beta-adrenergic agonist (10(-5) M) increased exclusively CFU-E growth after extreme influence. Thus, adrenergic mechanisms are of great importance in direct (receptor) and microenvironmental hemopoiesis-induced stimulation of the processes of proliferation and differentiation of hemopoietic precursors during stress.
Gol'dberg
E D
ED
Khlusov
I A
IA
Dygaĭ
A M
AM
Agafonov
V I
VI
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
D011941:Receptors, Adrenergic
Adrenergicheskie mekhanizmy kontrolia proliferatsii i differentsirovki krovetvornykh kletok-predshestvennikov v usloviiakh immobilizatsionnogo stressa.