title: [SP1 serum levels in pregnancy with Rh isoimmunization].
abstract: The authors examined in 37 pregnant women hospitalized on account of Rh incompatibility during the second and third trimester 71 serum specimens for levels of trophoblast specific beta 1-glycoprotein (SP1), using the method of simple radial immunodiffusion. In the group of 16 women with Rh incompatibility whose pregnancy terminated by delivery of a normal neonate, in 22% the SP1 levels were higher than 1.5 x the median value for the given gestation week (MoM). In 17 pregnancies where the foetus suffered from haemolytic disease the SP1 levels were higher than 1.5 MoM in 45% of the examined foetuses. Markedly elevated SP1 levels of 2.3 and 2.4 MoM were recorded in two pregnancies with hydrops of the foetus.
authors.affiliation: I. ústav pro lékarskou chemii a biochemii 1. LF UK, Praha.
authors.forename: L
authors.initials: L
authors.lastname: Fialová
authors.forename: I
authors.initials: I
authors.lastname: Malbohan
authors.forename: L
authors.initials: L
authors.lastname: Mikulíková
authors.forename: Z
authors.initials: Z
authors.lastname: Lacinová
authors.forename: Z
authors.initials: Z
authors.lastname: Hájek
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D012203:Rh Isoimmunization / Q000097:blood*
chemical_list: D011268:Pregnancy-Specific beta 1-Glycoproteins
vernacular_title: Sérové hladiny SP1 u tĕhotenství s Rh izoimunizací.