title: Zidovudine plus interferon alfa-2b treatment in patients with HIV and chronic active viral hepatitis.
abstract: Results are reported for a small study of 11 patients positive for HIV and with chronic active viral hepatitis. Low dose zidovudine/interferon alfa-2b combined treatment produced a general reduction in alanine aminotransferase activities and increased the CD4 lymphocyte count, hepatitis B e seroconversion, and the loss of HIV p24 antigen. The treatment was well tolerated and progression of HIV disease was not seen.
authors.affiliation: L. Spallanzani Hospital for Infectious Diseases, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Visco
authors.forename: L
authors.initials: L
authors.lastname: Alba
authors.forename: S
authors.initials: S
authors.lastname: Grisetti
authors.forename: P
authors.initials: P
authors.lastname: Guarascio
authors.forename: P
authors.initials: P
authors.lastname: Narciso
authors.forename: P
authors.initials: P
authors.lastname: Sette
authors.forename: C
authors.initials: C
authors.lastname: Struglia
authors.forename: G
authors.initials: G
authors.lastname: Tossini
authors.forename: V
authors.initials: V
authors.lastname: Tozzi
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000628:therapy*; D006509:Hepatitis B / Q000628:therapy; D006526:Hepatitis C / Q000628:therapy; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D011994:Recombinant Proteins; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D015215:Zidovudine