Microangiography--a sensitive method for studying experimental diabetic nephropathy.
Microangiographic and conventional histopathologic investigations of the kidney were compared in 15 alloxan diabetic and 7 nondiabetic control rats. Contrary to the relatively sparse histologic lesions, microangiography disclosed advanced vascular abnormalities, including arteriolar aneurysms, which increased with the duration of diabetes. It is concluded that microangiography is a sensitive and suitable method for studying the development of microvascular lesions of the kidney in experimental diabetes.
Merikanto
J
J
Department of Diagnostic Radiology, University Hospital, Umeå, Sweden.
Hietala
S O
SO
Lithner
F
F
Hägg
E
E
Päivänsalo
M
M
D000496:Alloxan; D000792:Angiography; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000000981:diagnostic imaging* / Q000473:pathology; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008833:Microcirculation / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012680:Sensitivity and Specificity
D000496:Alloxan