Control of inflammatory processes by adhesion glycoproteins.
Cell surface adhesive glycoproteins are principal regulators of nearly all aspects of immune/inflammatory responses. Using monoclonal antibodies to individual adhesion molecules, the expression and contribution of specific molecules in the pathogenesis of allergen-induced airway hyperresponsiveness in monkeys has been studied. Results confirm the importance of cell adhesion and demonstrate that antagonism of a single adhesion molecule may provide a novel therapeutic approach.
Wegner
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CD
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
Gundel
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RH
Churchill
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L
Letts
L G
LG
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004727:Endothelium / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007962:Leukocytes / Q000502:physiology; D011485:Protein Binding
D015815:Cell Adhesion Molecules