Direct determination of the enantiomers of halofantrine and its pharmacologically active metabolite N-desbutylhalofantrine by high-performance liquid chromatography.
The enantiomers of halofantrine and its main metabolite, N-desbutylhalofantrine, were separated on two different polysaccharide-based chiral stationary phases. The steroselective biotransformation of halofantrine was determined using rat liver homogenates. (-)-Halofantrine is metabolized preferentially.
Terefe
H
H
Institute of Pharmaceutical Chemistry, University of Münster, Germany.
Blaschke
G
G
D000818:Animals; D000962:Antimalarials / Q000032:analysis* / Q000493:pharmacokinetics; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D010616:Phenanthrenes / Q000032:analysis* / Q000493:pharmacokinetics; D051381:Rats; D013237:Stereoisomerism
D000962:Antimalarials; D010616:Phenanthrenes; C044961:1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol; C023768:halofantrine