Neurohypophyseal peptides as regulators of growth and development. A review.
In addition to their classical hormonal role, the neurohypophyseal peptides vasopressin (AVP) and oxytocin (OT) are also implicated as regulators of growth and development. Mitogenic actions of AVP are particularly well characterized and may underly the potential role of AVP as an autocrine regulator of tumor growth. Effects of AVP and OT on neural development are suggested by numerous studies, but definitive physiological evidence is lacking. Current studies on the molecular characterization of AVP and OT receptors, and on transgenic animals will provide insights into the developmental actions of neurohypophyseal peptides.
Carter
D A
DA
Neuropeptide Laboratory, National University of Singapore.
Fai
C K
CK
Murphy
D
D
D000818:Animals; D001127:Arginine Vasopressin / Q000502:physiology*; D001921:Brain / Q000254:growth & development; D002455:Cell Division; D006128:Growth / Q000502:physiology*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology; D010121:Oxytocin / Q000502:physiology*; D015290:Second Messenger Systems; D015398:Signal Transduction
D001127:Arginine Vasopressin; D010121:Oxytocin