title: Antiepileptic effect of antiepilepsirine in pentylenetetrazol and amygdala kindled rats.
abstract: Antiepilepsirine (AES) is a new antiepileptic drug developed in China. Anticonvulsant effects of AES were studied in both pentylenetetrazol (PTZ, n = 20) and amygdala kindled (n = 10) rats. AES was given once per day by oral gavage for 4 weeks. On days 7, 14, 21 and 28, all rats were tested 2 h after daily AES administration: PTZ and amygdala kindled rats were given a PTZ injection (30 mg/kg, i.p.) or amygdala stimulation (400 microA, 1 s), respectively. Behavior was observed, and seizures were graded. AES (300 or 500 mg/kg) produced sustained, dose dependent, protective effects against PTZ induced seizures in PTZ kindled rats, while AES (500 mg/kg) had no effects in amygdala kindled rats.
authors.affiliation: Children's Hospital, Columbus, OH 43205.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Vieth
authors.forename: R C
authors.initials: RC
authors.lastname: Landes
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: P D
authors.initials: PD
authors.lastname: Walson
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004827:Epilepsy / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000927:Anticonvulsants; D010880:Piperidines; C037547:ilepcimide; D010433:Pentylenetetrazole