Pharmacokinetic interaction between epirubicin and the multidrug resistance reverting agent D-verapamil.
The potential for a pharmacokinetic interaction between epirubicin and the second-generation multidrug resistance modulating agent D-verapamil (DVPM) has been investigated in six patients with advanced colorectal cancer. Our results indicate that a significant interaction takes place. Enhanced distribution of epirubicin from the serum and altered disposition might, in fact, explain the increased level of myelotoxicity in this pilot as well as in other clinical phase II studies involving DVPM.
Scheithauer
W
W
Department of Internal Medicine I, Vienna University Medical School, Austria.
Schenk
T
T
Czejka
M
M
D003110:Colonic Neoplasms / Q000188:drug therapy*; D004351:Drug Resistance; D015251:Epirubicin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use*
D015251:Epirubicin; D014700:Verapamil