Two-locus and bivariate segregation analysis of HDL-C and apo AI.
Two-locus and bivariate segregation analyses of HDL-C and apo AI were carried out using the GAW8 Berkeley data set. For HDL-C, results are ambiguous. Both the mixed environmental model and the mixed Mendelian model fit the data equally well. For apo AI, however, univariate one-locus segregation analysis suggests a Mendelian major gene controlling its levels. Moreover, two-locus analysis suggests a second major gene is involved. Bivariate segregation analysis indicates these data cannot resolve the question as to whether a single Mendelian major gene with pleiotropic effects controls levels of both HDL-C and apo AI in humans.
Xu
J F
JF
Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
Prenger
V L
VL
Coresh
J
J
Beaty
T H
TH
D016632:Apolipoprotein A-I / Q000235:genetics*; D008076:Cholesterol, HDL / Q000235:genetics*; D003198:Computer Simulation; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL