Pneumocystis carinii pneumonia among US children with perinatally acquired HIV infection.
OBJECTIVE
To describe epidemiologic characteristics of Pneumocystis carinii pneumonia (PCP) among children with perinatally acquired human immunodeficiency virus (HIV) infection to guide prevention efforts.


METHODS
National acquired immunodeficiency syndrome (AIDS) surveillance of children aged 0 through 12 years, a multisite surveillance study of HIV infection in children aged 0 through 12 years, and the national HIV serosurvey of childbearing women.


METHODS
Surveillance conducted by state and local health departments and reported to the Centers for Disease Control and Prevention 1982 through 1992.


RESULTS
Pneumocystis carinii pneumonia was reported in 1374 (37%) of 3665 perinatally acquired AIDS cases. Over half of these cases occurred between 3 and 6 months of age. In 183 (64%) of 275 PCP cases reported in the special surveillance study, PCP was the first or only AIDS-defining condition diagnosed, and in 44% of cases, the child had not been evaluated for HIV infection before diagnosis of PCP. The estimated median survival after diagnosis of PCP was 19 months.


CONCLUSIONS
Pneumocystis carinii pneumonia is a common and serious opportunistic infection that affects young children with HIV infection. Effective efforts to prevent PCP in this population will require identification as early as possible of children who may be infected with HIV.
Simonds
R J
RJ
Division of HIV/AIDS, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.
Oxtoby
M J
MJ
Caldwell
M B
MB
Gwinn
M L
ML
Rogers
M F
MF
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000151:congenital* / Q000401:mortality*; D006801:Humans; D007223:Infant; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D016036:Seroepidemiologic Studies; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology