title: Experimental evidence of genetic determinism in high susceptibility to intestinal pinworm infection in mice: a hybrid zone model.
abstract: In the hybrid zone of the two mouse subspecies Mus musculus musculus and Mus musculus domesticus, mice with hybrid genotypes harbour, on the average, more helminth parasites (cestodes and nematodes) than mice of the two parental taxa. In order to determine the roles played by genetic parameters in this phenomenon, mice with recombined and parental genotypes were experimentally infected with the intestinal pinworm Aspiculuris tetraptera, a natural parasite of the house mouse. The results showed that the high susceptibility of the hybrid zone mice is genetically determined. In addition, this study shows the occurrence of variability among resistant parental populations.
authors.affiliation: Laboratoire de Parasitologie Comparée (URA 698, CNRS), Université de Montpellier II, France.
authors.forename: C
authors.initials: C
authors.lastname: Moulia
authors.forename: N
authors.initials: N
authors.lastname: Le Brun
authors.forename: J
authors.initials: J
authors.lastname: Dallas
authors.forename: A
authors.initials: A
authors.lastname: Orth
authors.forename: F
authors.initials: F
authors.lastname: Renaud
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000835:Animals, Wild / Q000235:genetics / Q000469:parasitology; D003433:Crosses, Genetic; D003718:Denmark; D020022:Genetic Predisposition to Disease; D051379:Mice; D009349:Nematode Infections / Q000235:genetics*; D013045:Species Specificity; D014774:Virulence