[Rejection and tripterygium wilfordii treated small bowel allografts in pigs: pathological studies].
Segmental small bowel allografts in pigs were examined histologically to elucidate the rejection process. The specimens were obtained by biopsy at regular intervals after transplantation. Early characteristics of acute rejection were marked by infiltration of mononuclear cells in the lamina propria. Moderate rejection showed increased infiltrated mononuclear cells and mucosal lesions. Mucosal necrosis occurred in the acute phase of rejection. Rejection was seen in the animals that received only low-dose cyclosporin A but not in those treated with tripterygium wilfordii (TW) and low-dose cyclosporin A. These results suggest that mucosal biopsy as a way of monitoring rejection can show sequential pattern of changes. Normal morphological appearance of TW-treated allografts confirmed that TW is an effective immunosuppressant.
Zhou
Z S
ZS
Department of Pathology and General Surgery, Jinling Hospital, Nanjing.
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology / Q000637:transplantation*; D013552:Swine; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents