Adducts to macromolecules in the biological monitoring of workers exposed to polycyclic aromatic hydrocarbons.
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants. Human exposure occurs through diet, smoking, and polluted air. In some groups of workers exposed to PAHs, epidemiological studies have revealed an increased mortality risk for neoplasms. This paper reviews the principal methods that have been developed recently for the detection of PAH adducts to white blood cell DNA and blood proteins (hemoglobin, albumin) and summarizes observations made on occupationally exposed subjects.
dell'Omo
M
M
Unit of Industrial Toxicology and Occupational Medicine, Catholic University of Louvain, Clos Chapelle-aux-Champs, Brussels, Belgium.
Lauwerys
R R
RR
D001798:Blood Proteins / Q000187:drug effects*; D004247:DNA / Q000187:drug effects*; D004784:Environmental Monitoring; D006801:Humans; D016273:Occupational Exposure; D011083:Polycyclic Compounds / Q000633:toxicity*
D001798:Blood Proteins; D011083:Polycyclic Compounds; D004247:DNA