Effects of the sesquiterpene capsidiol on isolated guinea-pig ileum and trachea, and on prostaglandin synthesis in vitro.
The sesquiterpene capsidiol, isolated from elicited, cultured cells of Nicotiana silvestris, inhibits contraction induced by the agonists, histamine, acetylcholine, bradykinin, and barium chloride in the isolated guinea-pig ileum. In addition, capsidiol inhibits contraction induced by histamine and carbachol in the isolated guinea-pig trachea in a nonspecific and noncompetitive but concentration-dependent manner. Capsidiol also inhibits prostaglandin synthesis (cyclooxygenase) in vitro in a concentration dependent manner.
Nasiri
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Department of Pharmacognosy, Biomedical Centre of Uppsala University, Sweden.
Holth
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Björk
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D000818:Animals; D002478:Cells, Cultured; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010947:Plants, Toxic; D011453:Prostaglandins / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes; D014026:Nicotiana / Q000737:chemistry* / Q000166:cytology; D014132:Trachea / Q000187:drug effects; D000094162:Phytoalexins
D010276:Parasympatholytics; D010936:Plant Extracts; D011453:Prostaglandins; D012717:Sesquiterpenes; D013729:Terpenes; C081843:capsidiol; D000094162:Phytoalexins