[The enhanced bioavailability of mebendazole in echinococcosis patients when used with Essentiale].
Mebendasole is better absorbed in the gastrointestinal tract if administered together with essential to patients with hydatid disease. Thirty-four patients with alveolar and hydatid echinococcosis were administered mebendasol in a daily dose of 50 mg/kg in 4 doses and essentiale in a daily dose of 600-1000 mg in 4 doses. A total of 86 therapeutic courses, 30 days each, were carried out. The treatment was sufficiently well tolerated. Mebendasole levels in the course of therapy surpassed the minimal effective ones in 2/3 of the patients, that is, they were significantly higher than in administration of mebendasole alone.
Shcherbakov
A M
AM
Lur'e
A A
AA
D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002648:Child; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004443:Echinococcosis / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D013997:Time Factors
D010713:Phosphatidylcholines; C011246:essential 303 forte; D008463:Mebendazole
Povyshenie biodostupnosti mebendazola u bol'nykh ékhinokokozami pri ego primenenii s éssentsiale.