title: [Value of thrombolytic therapy in childhood].
abstract: Indications for fibrinolytic therapy in infants and young children differ significantly from those in adults. In preterm and newborn infants, it is mostly the catheter-associated thrombosis following catheterisation of the umbilical artery or vein that requires fibrinolytic therapy. In young children the main indication is arterial thrombosis after cardiac catheterisation. Based on the current literature and our own experience guidelines as well as recommendations for dosages are given for systemic and local therapy with streptokinase, urokinase and recombinant tissue plasminogen activator.
authors.affiliation: Abt. III Pädiatrische Kardiologie, Medizinischen Hochschule, Hannover.
authors.forename: M
authors.initials: M
authors.lastname: Wilken
mesh_terms: D001780:Blood Coagulation Tests; D002408:Catheters, Indwelling; D002648:Child; D000075202:Contraindications; D004305:Dose-Response Relationship, Drug; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005343:Fibrinolytic Agents
vernacular_title: Stellenwert der Thrombolysetherapie im Kindesalter.