Effect of desmopressin (DDAVP) on protein C and protein C inhibitors in uremia.
The effect of desmopressin (DDAVP) on protein C (PC) and PC inhibitors was investigated in 7 uremic predialysis patients, 7 hemodialysis patients and 7 controls. Significant decrease in PC activity was observed in all groups after DDAVP administration. Desmopressin did not influence PC antigen and two well-known PC inhibitors, plasminogen activator inhibitor-3 and alpha 1-antitrypsin. Thus, it is suggested that DDAVP-induced decrease in PC activity is not related to the changes in PC inhibitors; further studies are needed to clarify the precise mechanisms of the effect of DDAVP on PC in uremia.
Akpolat
T
T
Hacettepe University School of Medicine, Department of Nephrology, Ankara, Turkey.
Ozdemir
O
O
Arik
N
N
Demirkan
F
F
Sungur
C
C
Ozcebe
O
O
Dündar
S
S
Yasavul
U
U
Turgan
C
C
Kirazli
S
S
D000328:Adult; D000941:Antigens / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood; D011486:Protein C / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism*; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D000941:Antigens; D015849:Plasminogen Inactivators; D011486:Protein C; D000515:alpha 1-Antitrypsin; D003894:Deamino Arginine Vasopressin