title: Effect of ignoring genotype-environment interaction on segregation analysis of quantitative traits.
abstract: Thirty replicates of 200 nuclear families (6 members each) were generated under three GxE interaction models. Segregation analyses of these data were performed using a regressive model taking into account an interaction effect or not. Results showed that ignoring the GxE interaction markedly decreased the power for accepting a major gene and led to serious bias in parameter estimates.
authors.affiliation: INSERM, Unité 258, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Tiret
authors.forename: L
authors.initials: L
authors.lastname: Abel
authors.forename: R
authors.initials: R
authors.lastname: Rakotovao
mesh_terms: D000328:Adult; D002675:Child, Preschool; D003327:Coronary Disease / Q000235:genetics*; D004777:Environment; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009010:Monte Carlo Method; D012044:Regression Analysis