title: Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids.
abstract: The effect of fats high in individual, prevalent saturated dietary fatty acids on lipoproteins and hemostatic variables in young healthy subjects was evaluated in a randomized strictly controlled metabolic feeding study. Three experimental diets: shea butter (S; 42% stearic acid), palm oil (P; 43% palmitic palmitic acid), and palm-kernel oil with high-oleic sunflower oil (ML; 10% myristic acid, 30% lauric acid) were served to 15 men for 3 wk each, separated by washout periods. Diet S compared with diet P resulted in significant reduction in plasma cholesterol (22%) LDL cholesterol (26%), apolipoprotein B (18%), HDL cholesterol (12%), apolipoprotein A-I (13%), and a 13% lower factor VII coagulant activity (P = 0.001). Similar differences were observed between diets S and ML. In conclusion, intake of shea butter high in stearic acid favorably affects blood lipids and factor VII coagulant activity in young men, compared with fats high in saturated fatty acids with 12-16 carbons.
authors.affiliation: Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Tholstrup
authors.forename: P
authors.initials: P
authors.lastname: Marckmann
authors.forename: J
authors.initials: J
authors.lastname: Jespersen
authors.forename: B
authors.initials: B
authors.lastname: Sandström
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001054:Apolipoproteins A / Q000032:analysis; D001055:Apolipoproteins B / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D005167:Factor VII / Q000032:analysis*; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007850:Lauric Acids / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008297:Male; D019814:Myristic Acid; D009227:Myristic Acids / Q000494:pharmacology; D010169:Palmitic Acids / Q000494:pharmacology; D010960:Plasminogen Activators / Q000097:blood; D012712:Serum Globulins / Q000032:analysis; D013229:Stearic Acids / Q000494:pharmacology
chemical_list: D001054:Apolipoproteins A; D001055:Apolipoproteins B; D004041:Dietary Fats; D005227:Fatty Acids; D007850:Lauric Acids; D008055:Lipids; D009227:Myristic Acids; D010169:Palmitic Acids; D012712:Serum Globulins; D013229:Stearic Acids; D019814:Myristic Acid; C030358:lauric acid; C031183:stearic acid; D005167:Factor VII; D002784:Cholesterol; D010960:Plasminogen Activators