[Physiological and pathophysiological role of endothelin-endothelin receptors system in cardiovascular system].
Since the discovery of a potent endothelium-derived vasoconstrictor peptide, termed endothelin (ET) in 1988, recent studies using molecular biology technique have revealed the existence of ET isopeptides (ET-1, ET-2, ET-3) and receptor subtypes (ETA, ETB). In cardiovascular system, ET family plays important roles not only in regulation of vascular tonus as a vasoconstrictor, but also in cardiovascular remodeling as a growth factor. Development and application of antagonists selective for ETA and ETB receptor and inhibitor of ET-converting enzyme should elucidate pathophysiological roles of ET family and its receptors in cardiovascular diseases.
Hirata
Y
Y
2nd Department of Internal Medicine, Tokyo Medical and Dental University.
D000595:Amino Acid Sequence; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D016232:Endothelins / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D017466:Receptors, Endothelin / Q000737:chemistry*
D016232:Endothelins; D017466:Receptors, Endothelin