The use of platelets as models for neurons: possible applications to the investigation of eating disorders.
The pathogenesis of eating disorders is still unclear. However, there is evidence that neurotransmitters may be involved in the control of satiety/appetite. Investigating these disorders could be facilitated if a readily available human cell model were to reflect central nervous system (CNS) function. Platelets may satisfy, at least partially, this requirement. We discuss here the use of platelets as neuronal models with an emphasis on eating disorders.
Barradas
M A
MA
Department of Chemical Pathology & Human Metabolism, Royal Free Hospital School of Medicine, (University of London), UK.
Mikhailidis
D P
DP
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism; D001068:Feeding and Eating Disorders / Q000378:metabolism*; D066298:In Vitro Techniques; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*