[The effect of foridon on the cerebral circulation in non-narcotized animals].
In chronic experiments in rabbits, foridone, 0.3 mg/kg, i.v., caused a significant increase in overall and local cerebral circulation and pO2 in various brain regions. In conscious rats, foridone given in the same dose under 30-min carotid occlusion resulted in a less profound decrease in brain blood supply to the baseline level during recirculation and prevented disturbances in oxidative processes in brain tissue and development of brain edema.
Miller
L G
LG
Zakharova
M A
MA
Dubur
G Ia
GIa
Kastron
V V
VV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D002121:Calcium Channel Blockers; D009543:Nifedipine; C045912:ryodipine
Vliianie foridona na mozgovoe krovoobrashchenie u nenarkotizirovannykh zhivotnykh.