title: Effect of growth hormone treatment on craniofacial growth in Turner's syndrome.
abstract: A cephalometric study was performed in 19 patients with Turner's syndrome, aged 8.7-16.5 years. A lateral roentgen-encephalogram was taken before and after two years of treatment with biosynthetic growth hormone in a dose of 24 IU/m2/week. During two years of growth hormone treatment, the mandibular length increased mainly due to vertical growth. The initially posteriorly rotated mandible showed an anterior rotation, although the normal position was not reached. The other linear measurements and angles did not change during treatment. No indications were found for an increase in the disproportionate growth or for excessive chin growth as a sign of acromegaly during growth hormone treatment. In conclusion, growth hormone treatment in patients with Turner's syndrome resulted in an increase in mandibular length, mainly due to vertical growth of the ramus and in the anterior rotation of the mandible.
authors.affiliation: Department of Paediatrics, University of Utrecht, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Rongen-Westerlaken
authors.forename: E
authors.initials: E
authors.lastname: vd Born
authors.forename: B
authors.initials: B
authors.lastname: Prahl-Andersen
authors.forename: A
authors.initials: A
authors.lastname: von Teunenbroek
authors.forename: P
authors.initials: P
authors.lastname: Manesse
authors.forename: B J
authors.initials: BJ
authors.lastname: Otten
authors.forename: I
authors.initials: I
authors.lastname: vd Tweel
authors.forename: A M
authors.initials: AM
authors.lastname: Kuijpers-Jagtman
authors.forename: H A
authors.initials: HA
authors.lastname: Delemarre vd Waal
authors.forename: N M
authors.initials: NM
authors.lastname: Drayer
mesh_terms: D000172:Acromegaly / Q000139:chemically induced; D000293:Adolescent; D002508:Cephalometry; D002648:Child; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008334:Mandible / Q000187:drug effects / Q000254:growth & development; D008445:Maxillofacial Development / Q000187:drug effects*; D012886:Skull / Q000187:drug effects / Q000254:growth & development; D014424:Turner Syndrome / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D013006:Growth Hormone