[Clinico-radiological correlation in thalassemia intermedia].
Fifteen thalassemia intermedia patients were considered, whose clinical and radiological findings were examined and compared. Eight patients underwent regular transfusion therapy. All patients underwent total body CT: the volume of ectopic erythropoiesis foci was calculated by a digital calculation algorithm (ROI volume). This work was aimed at correlating the quantitative measures of ectopic erythropoiesis assessed by CT with serum level of erythropoietin (EPO) and of trasferrin-free receptors (TfR) in both transfused and non-transfused patients, also considering the volume changes of ectopic erythropoiesis and bone changes over 36 months' follow-up. A direct correlation was demonstrated between serum transferrin and ectopic erythropoietic masses in transfusion-dependent patients: in fact, increased values of serum transferrin correspond to the enlargement of these masses and to bone lesion worsening.
Sergiacomi
G
G
Istituto di Radiologia, Università degli Studi di Roma Tor Vergata, Ospedale S. Eugenio, Roma.
Palma
E
E
Cianciulli
P
P
Forte
L
L
Papa
G
G
Simonetti
G
G
D000293:Adolescent; D000328:Adult; D002648:Child; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D008297:Male; D011990:Receptors, Transferrin / Q000032:analysis; D014057:Tomography, X-Ray Computed; D017086:beta-Thalassemia / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology
D011990:Receptors, Transferrin; D004921:Erythropoietin
Correlazioni clinico-radiologiche nella talassemia intermedia.