title: Recombinant alpha interferon for chronic hepatitis B in anti-HIV positive patients receiving zidovudine.
abstract: In this pilot study of the effects of interferon alfa in 10 anti-HIV positive, chronic hepatitis B patients treated with zidovudine (AZT), tolerance to interferon was good and similar to that in anti-HIV negative patients. After treatment, the HIV stage and CD4 lymphocyte count were unchanged. In two patients hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg) disappeared and the serum alanine aminotransferase (ALT) returned to normal; loss of hepatitis B surface antigen (HBsAg) with absence of histopathological activity was observed after treatment in one of these patients. These preliminary results need to be confirmed by a larger study.
authors.affiliation: Service d'Hépatologie, Hôpital Beaujon, Clichy, France.
authors.forename: P
authors.initials: P
authors.lastname: Marcellin
authors.forename: N
authors.initials: N
authors.lastname: Boyer
authors.forename: J F
authors.initials: JF
authors.lastname: Colin
authors.forename: M
authors.initials: M
authors.lastname: Martinot-Peignoux
authors.forename: V
authors.initials: V
authors.lastname: Lefort
authors.forename: S
authors.initials: S
authors.lastname: Matheron
authors.forename: S
authors.initials: S
authors.lastname: Erlinger
authors.forename: J P
authors.initials: JP
authors.lastname: Benhamou
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006679:HIV Seropositivity / Q000150:complications / Q000628:therapy*; D006509:Hepatitis B / Q000150:complications / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011994:Recombinant Proteins; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D015215:Zidovudine