Effect of triacylglycerols on erythrocyte deformability in vitro.
With Reid's filtration technique as a bioassay for evaluating red blood cell (RBC) deformability, we found that tripalmitolein, triolein and trilinolein improved the deformability of calcium-loaded RBC while glycerol, linoleic acid, dilinoleoyl phosphatidyl choline, trilpalmitin, tristearin, trilinolenin and triarachidonin did not. Maximal effect of tripalmitolein, triolein and trilinolein was achieved at 10(-9), 10(-10) and 10(-8) M respectively. We propose that only those triacylglycerols which contain fatty acids with one or two double bonds could modify RBC membrane fluidity and improve RBC deformability.
Hong
C Y
CY
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, ROC.
Lai
L J
LJ
Shiao
M S
MS
Chiang
B N
BN
D004305:Dose-Response Relationship, Drug; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006801:Humans; D014280:Triglycerides / Q000494:pharmacology*
D014280:Triglycerides