[The effectiveness of immunization with vaccinia virus type "MVA" against an infection with cowpox virus type "OPV 85" in rabbits].
The immunological efficacy of vacciniavirus "MVA" was tested against a dermal and intradermal infection with cowpoxvirus "OPV 85" in rabbits: A single vaccination with "MVA" provided only insufficient immunity, a revaccination induced good immunity. Intramuscular immunizations protected better than subcutaneous applications. Immunized rabbits showed "revaccination reactions" after infection with "OPV 85" indicating a cellular immunity. After immunization with "MVA" and after infection with cowpoxvirus "OPV 85" all rabbits developed N- and ELISA-antibodies. HAI-antibodies were not found after immunization, but indicated a multiplication of cowpoxvirus after challenge. Vacciniavirus "MVA" is suggested for immunization of man and animal against possible infections with cowpoxvirus and cowpoxlike viruses.
Munz
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E
Institut für Vergleichende Tropenmedizin und Parasitologie, Tierärztliche Fakultät, Universität München, Deutschland.
Linckh
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S
Renner-Müller
I C
IC
Reimann
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M
D000818:Animals; D015605:Cowpox / Q000517:prevention & control* / Q000662:veterinary; D007273:Injections, Intramuscular / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D011817:Rabbits; D014611:Vaccination / Q000662:veterinary; D014616:Vaccinia virus / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage
D014765:Viral Vaccines
Die Wirksamkeit einer Immunisierung mit Vaccinia-Virus Stamm "MVA" gegen eine Infektion mit Kuhpocken-Virus Stamm "OPV 85" beim Kaninchen.