A defect in the neuroendocrine axis in rheumatoid arthritis: pathogenetic implications.
Evidence is presented that there is a defect in the hypothalamic response to inflammatory stimuli in patients with rheumatoid arthritis which leads to a subnormal cortisol response. This defect may be one factor contributing to the chronicity of RA.
Panayi
G S
GS
United Medical School, Guy's Hospital, London, U.K.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007249:Inflammation / Q000209:etiology; D009490:Neurosecretory Systems / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology
D006854:Hydrocortisone