[Anti-ulcer effect of the drug OF-743 in an acid model of ulcer formation by the Okabe method].
The application of acetic acid (100%) on gastric serosa produces hemorrhagic lesions, erosions and ulcers in the gastric mucosa of rats. Intraperitoneal injections of OF-743, a derivative of sydnonimine during 3 days after the acid application have revealed lesser expressed mucosal lesions: only hemorrhagic lesions and rather small erosions. The lesions degree in rats subjected to the action of OF-743 was 2.7 as compared with 4.4 in control rats without OF-743. Our findings indicate that OF-743 shows not only protective antiulcer action, as it was discovered earlier, but has also curative antiulcer effect.
Iuziuk
T N
TN
Samonina
G E
GE
Ashmarin
I P
IP
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D013558:Sydnones / Q000627:therapeutic use*
D000085:Acetates; D000897:Anti-Ulcer Agents; D013558:Sydnones; C072808:OF 743; D019342:Acetic Acid
Protivoiazvennyĭ éffekt preparata OF-743 na kislotnoĭ modeli iazvoobrazovaniia po metody Okabe.