title: [Ultrastructural study of azidothymidine-induced melanoderma in an AIDS patient].
abstract: We report an ultrastructural study of azidothymidine-induced melanoderma. The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis, and in dermal Factor XIIIa-positive dendrocytes. Such observation suggests an increased melanogenesis in melanocytes associated to a defect in the degradation of melanosomes normally occurring during epidermal maturation.
authors.affiliation: Service de Dermatopathologie, CHU du Sart Tilman, Université de Liège.
authors.forename: T
authors.initials: T
authors.lastname: Hermanns-Lê
authors.forename: F
authors.initials: F
authors.lastname: Gérardy-Goffin
authors.forename: M
authors.initials: M
authors.lastname: Giet-Lesuisse
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000473:pathology*; D012867:Skin / Q000648:ultrastructure; D015215:Zidovudine / Q000009:adverse effects*
chemical_list: D015215:Zidovudine
vernacular_title: Etude ultrastructurale de la mélanodermie induite par l'azidothymidine chez un patient sidéen.