title: [The effect of the amino sugar glucosamine on the endogenous intoxication processes in pulmonary edema in rats].
abstract: The effects of glycosamine aminosugar on the processes of endotoxicosis and lipid peroxidation were thoroughly studied in rats with toxic pulmonary edema. There was a glycosamine-induced decrease in markers of endotoxicosis, such as medium-weight molecular peptides and malonic dialdehyde in serum and lung tissue. Administration of exogenous glucosamine resulted in its incorporation into the membranes of target organs, connective tissue and normalized the levels of endogenous N-acetyl-glucosamine, which finally determined antitoxic and antioxidative properties in this aminosugar.
authors.forename: S I
authors.initials: SI
authors.lastname: Pliushch
authors.forename: I A
authors.initials: IA
authors.lastname: Zupanets
authors.forename: S M
authors.initials: SM
authors.lastname: Drogovoz
authors.forename: S G
authors.initials: SG
authors.lastname: Isaev
mesh_terms: D000643:Ammonium Chloride; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005944:Glucosamine / Q000378:metabolism / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D046911:Macromolecular Substances; D008315:Malondialdehyde / Q000378:metabolism; D008970:Molecular Weight; D010455:Peptides / Q000187:drug effects / Q000378:metabolism; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats
chemical_list: D046911:Macromolecular Substances; D010455:Peptides; D000643:Ammonium Chloride; D008315:Malondialdehyde; D005944:Glucosamine
vernacular_title: Vliianie aminosakhara gliukozamina na sostoianie protsessov éndotoksikoza pri oteke legkikh u krys.