Occurrence of paroxysmal synchronous EEG discharges in subcortical arteriosclerotic encephalopathy (Binswanger's disease).
A 72-year-old patient with von Recklinghausen's disease showed akinetic mutism within 6 months of the onset of dementia. The findings of diffuse cerebral atrophy on CT and periodic synchronous discharges (PSDs) in EEG suggested Creutzfeldt-Jakob disease. However, autopsy findings of diffuse softening of the subcortical white matter and marked arteriosclerotic changes of the subcortical arterioles with sparing of the cortex in the cerebrum confirmed a diagnosis of Binswanger's disease. Binswanger's disease should be included in the differential diagnosis of dementia showing PSDs in EEG.
Kuroda
Y
Y
Department of Internal Medicine, Saga Medical School, Japan.
Ikeda
A
A
Kurohara
K
K
Kakigi
R
R
Ryuh
S
S
Kouda
H
H
Misago
N
N
Sugihara
H
H
D000368:Aged; D001344:Autopsy; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D006801:Humans; D008297:Male; D017253:Neurofibromatoses / Q000150:complications