Noninvasive measurement of human ascending colon volume.
The capacitance and motor functions of the colon are important determinants of its overall function. A simple, noninvasive method to quantify regional colonic volume is required for further physiologic and pharmacologic studies. Our aim was to determine whether measurements of human ascending colon (AC) volume using two-dimensional (2-D) images are as accurate as estimates using three-dimensional (3-D) images. Five healthy male volunteers each ingested a methacrylate-coated capsule containing 99Tcm-labelled Amberlite pellets. Two-and 3-D images were obtained using a gamma camera with single photon emission computed tomography (SPECT) capability. Ascending colon volume was estimated by a variable region of interest (VROI) program and by full-width half-maximum (FWHM) analysis, and results were compared to the volume estimates by SPECT. Full-width half-maximum analysis yielded volume estimates that were not significantly different from SPECT (slope = 1.093; t = 0.51; P > 0.5), whereas VROI estimates were significantly different from volume measurements by SPECT and, hence, considered less accurate (slope = 0.438; t = 4.93; P < 0.02). Thus, the less expensive and more easily available planar imaging technique with analysis by FWHM estimates AC volume as accurately as SPECT.
Badley
A D
AD
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905.
Camilleri
M
M
O'Connor
M K
MK
D000328:Adult; D002214:Capsules; D003106:Colon / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008689:Methacrylates; D012117:Resins, Synthetic / Q000008:administration & dosage; D013667:Technetium / Q000008:administration & dosage; D015899:Tomography, Emission-Computed, Single-Photon
D002214:Capsules; D008689:Methacrylates; D012117:Resins, Synthetic; D013667:Technetium; C046797:amberlite