[The effect of genetically determined factors on the development and course of sarcoidosis].
Intricate aspects of sarcoidosis course are studied. Examination included 75 Russian patients with sarcoidosis of the respiratory organs: 44 of them had newly diagnosed process and its spontaneous regression and in 31 the disease took a recurrent course. In all patients the HLA system of classes I and II were detected by means of a standard microlymphocytotoxic test; electrophoresis in polyacrylamide and starch gels was used to determine the genotypes of erythrocyte enzymes and/the groups of specific proteins. In sarcoidosis patients the rate of occurrence of antigens B7 and B8 was characteristically increased (22.7 and 27.3%) as compared to the group of healthy subjects (21.5 and 15.1%) and there was a rise of total homozygosity and heterozygosity reduction for the ESD, ACP, PGM-1 loci, which obviously may affect the disease course. Investigations are in progress.
Dushimbekova
K A
KA
Romanov
V V
VV
Pospelov
L E
LE
D000328:Adult; D001798:Blood Proteins / Q000235:genetics; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012008:Recurrence; D012426:Russia; D012507:Sarcoidosis / Q000097:blood / Q000208:ethnology / Q000235:genetics*
D001798:Blood Proteins; D006680:HLA Antigens
Vliianie genetichski determinirovannykh faktorov na razvitie i techenie sarkoidoza.