Different effects of three aldosterone treatments on plasma aldosterone and salt intake.
Adrenalectomized male rats received a nominal dose of 47.6 micrograms/day aldosterone for 14 days by daily injections, osmotic minipumps, or controlled-release pellets. Plasma aldosterone concentrations were barely detectable (< 20 pg/ml) 24 h after rats received aldosterone by injection, remained constant at 200 pg/ml in rats with osmotic minipumps, and dropped from > 500 to 75 pg/ml during the first week after implantation of controlled-release pellets. For the most part, the effects of the different treatments on NaCl intake were related to their effects on plasma aldosterone levels according to a U-shaped function. However, NaCl intake was dissociated from plasma aldosterone levels when treatment first began or was discontinued. NaCl intake may be a function of the amount of aldosterone delivered but not necessarily plasma aldosterone concentration.
Tordoff
M G
MG
Monell Chemical Senses Center, Philadelphia, PA 19104-3308.
Hughes
R L
RL
Pilchak
D M
DM
D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology; D000450:Aldosterone / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects / Q000502:physiology; D004435:Eating / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012982:Sodium, Dietary / Q000008:administration & dosage*; D014882:Water-Electrolyte Balance / Q000187:drug effects* / Q000502:physiology
D012982:Sodium, Dietary; D000450:Aldosterone