[The character of the interaction of beta-carotene-15,15'-dioxygenase from rabbit small intestine with lycopene, 15,15'-dehydro-beta-carotene, lutein, and astaxanthine].
Interaction of rabbit small intestine mucosa beta-carotene 15,15'-dioxygenase with lycopene, 15,15'-dehydro-beta-carotene, lutein and astaxanthine is unaccompanied by the formation of products of enzymatic cleavage of the central double bond of these carotenoid molecules. Apo-carotenoids of lutein and lycopene are formed by nonenzymatic oxidation. Lycopene and 15,15'-dehydro-beta-carotene competitively inhibit the enzymatic oxidation of beta-carotene. Inhibition of the enzyme conversion by lutein and astaxanthin is less strong, being of a competitive-noncompetitive type. Enzymatic formation of retinal from beta-carotene depends on the accessibility of substrate molecules.
Ershov
Iu V
IuV
Dmitrovskiĭ
A A
AA
Bykhovskiĭ
V Ia
VIa
D000818:Animals; D002338:Carotenoids / Q000031:analogs & derivatives* / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology*; D014975:Lutein / Q000378:metabolism*; D000077276:Lycopene; D010105:Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011817:Rabbits; D012172:Retinaldehyde / Q000096:biosynthesis; D013379:Substrate Specificity; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives*; D050559:beta-Carotene 15,15'-Monooxygenase
D024341:Xanthophylls; D019207:beta Carotene; D002338:Carotenoids; C082383:15,15'-dehydro-beta-carotene; C005948:astaxanthine; D010105:Oxygenases; D050559:beta-Carotene 15,15'-Monooxygenase; D012172:Retinaldehyde; D000077276:Lycopene; D014975:Lutein
O kharaktere vzaimodeĭstviia beta-karotin-15,15'-dioksigenazy iz tonkogo kishechnika krolika s likopinom, 15,15'-degidro-beta-karotinom, liuteinom i astaksantinom.