Linkage analysis of Alzheimer's disease with methods using relative pairs.
Four relative-pair methods for detecting genetic linkage were applied to familial Alzheimer's disease data. Results obtained using an extended Haseman-Elston test and a weighted rank pairwise correlation test, which both use information from all relative pairs, were consistent with previously published likelihood results and appear to be more powerful than affected sib pair methods.
Blossey
H
H
Department of Statistics, University of Washington, Seattle 98195.
Commenges
D
D
Olson
J M
JM
D000544:Alzheimer Disease / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D016555:Matched-Pair Analysis; D010375:Pedigree
D005819:Genetic Markers