Marked pulmonary function abnormalities in a case of HIV-associated pulmonary hypertension.
Recent reports have suggested an association between primary pulmonary hypertension and human immunodeficiency virus (HIV) infection. This appears to be an accelerated syndrome, associated with a relatively brief duration of symptoms, yet prominent right ventricular failure and severe pulmonary hypertension on presentation. We present a case of a primary pulmonary hypertension in a 35-year-old HIV-seropositive hemophiliac. His accelerated clinical course is consistent with previously reported cases of HIV-related pulmonary hypertension. However, this patient's pulmonary function tests revealed marked hyperinflation, a decreased diffusing capacity, and no airflow obstruction. To our knowledge, this very usual constellation of pulmonary function changes has not been described previously in this syndrome.
Diaz
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Department of Internal Medicine, Ohio State University, Columbus.
Clanton
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TL
D000328:Adult; D002303:Cardiac Output, Low / Q000150:complications / Q000503:physiopathology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D016278:Ventricular Function, Right