Acetylation phenotypes and environmental chemical exposure of people with idiopathic systemic lupus erythematosus.
OBJECTIVE
To test the hypotheses that there is an excess percentage of slow acetylators among patients with idiopathic systemic lupus erythematosus (SLE) and that these patients had excessive exposure to environmental amines and hydrazines before the onset of illness.


METHODS
Case-control study with structured interview and acetylation phenotyping.


RESULTS
No excess proportion of slow acetylators or environmental amine exposure was found.


CONCLUSIONS
Slow acetylation phenotype and exposure to environmental amines are not principal causes of idiopathic SLE.
Reidenberg
M M
MM
Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
Drayer
D E
DE
Lorenzo
B
B
Strom
B L
BL
West
S L
SL
Snyder
E S
ES
Freundlich
B
B
Stolley
P D
PD
D000107:Acetylation / Q000187:drug effects; D000328:Adult; D000588:Amines / Q000494:pharmacology*; D003622:Dapsone / Q000008:administration & dosage; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012907:Smoking / Q000009:adverse effects
D000588:Amines; D006834:Hydrazines; D003622:Dapsone