title: Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens.
abstract: Human colonic intraepithelial lymphocytes from control subjects down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens or phytohaemagglutinin (PHA). In contrast, human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens. These findings may be important in the development and maintenance of the mucosal immunological activation of inflammatory bowel disease.
authors.affiliation: Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Dalton
authors.forename: M C
authors.initials: MC
authors.lastname: Dipaolo
authors.forename: G K
authors.initials: GK
authors.lastname: Sachdev
authors.forename: B
authors.initials: B
authors.lastname: Crotty
authors.forename: P
authors.initials: P
authors.lastname: Hoang
authors.forename: D P
authors.initials: DP
authors.lastname: Jewell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000276:immunology*; D002478:Cells, Cultured; D003093:Colitis, Ulcerative / Q000276:immunology; D003106:Colon / Q000276:immunology* / Q000473:pathology; D003424:Crohn Disease / Q000276:immunology; D015536:Down-Regulation / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013745:Tetanus Toxoid / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D010835:Phytohemagglutinins; D013745:Tetanus Toxoid