[Histopathological study of subcutaneous heterograft of human gastric cancer in nude mice treated with 211At labelled monoclonal antibody].
The histopathological changes of subcutaneous heterograft of human gastric cancer in nude mice were examined 5-10 days after intravenous injection of a single dose of 211At labelled McAb(211At-3H11). The results showed that there was a relatively selective localization and therapeutic effect as biomissile, which led to a radiation response of gastric cancer cells (GCCs) and decreased the mitosis of GCCs with a dose-response correlation among the 8, 16, and 24 microCi 211At-3H11 groups. The effectiveness of a single dose of 211At-3H11 injected intravenously in the tumor bearing nude mice lasted not longer than 5-6 days, meanwhile in the mice exposed to the dosage of 16 or 24 microCi, mitosis in GCCs disappeared, and at the same time there was no obvious repair or regeneration of GCCs.
Luo
D Y
DY
Institute for Nuclear Science and Technology, Sichuan University, Chengdu.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001246:Astatine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy*
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D001246:Astatine