Use of viscosigens to stabilize vitamin B12 solutions against photolysis.
Glycerol stabilizes cyanocob(III)alamin (vitamin B12) against anaerobic photolysis by a high-intensity UV light source or a low-intensity fluorescent light source. The likely mechanism for stabilization by viscosigens is a decrease in diffusion and an enhancement of radical-pair recombination. Glycerol (25% or greater) stabilizes therapeutic doses of vitamin B12 in single-dose Tubex injection vials against adventitious photolysis by fluorescent light.
Grissom
C B
CB
Department of Chemistry, University of Utah, Salt Lake City 84112.
Chagovetz
A M
AM
Wang
Z
Z
D004058:Diffusion; D004355:Drug Stability; D005362:Ficoll / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry*; D008027:Light; D012996:Solutions; D014466:Ultraviolet Rays; D014783:Viscosity; D014805:Vitamin B 12 / Q000737:chemistry* / Q000528:radiation effects*
D012996:Solutions; D005362:Ficoll; D014805:Vitamin B 12; D005990:Glycerol