[The effects of intravenous lidocaine on baroreflex control of heart rate in man].
The effects of intravenous lidocaine on arterial baroreflex control of heart rate were investigated using both the pressor and depressor tests in 16 adult patients. Baroreflex sensitivity was unchanged 5 and 20 minutes after lidocaine 1.5 mg.kg-1 bolus injection according to the results of both the pressor and depressor tests. Resetting of the baroreflex, tachycardia and increased blood pressure were also observed after lidocaine injection. Clinically the results obtained in the present study suggest that it is safe to use lidocaine even when reduction of blood pressure by hypovolemia or declamping the main artery is expected and when a rise in blood pressure due to cross-clamping of the main artery is foreseen. However, intravenous lidocaine tended to produce tachycardia, and baroreflex sensitivity was unchanged after lidocaine injection according to the results of the depressor test. This means that tachycardia readily occurs during hypotension. This may suggest that intravenous lidocaine is not always advantageous for patients with ischemic heart disease.
Wajima
Z
Z
Department of Anesthesiology, Nippon Medical School, Tokyo.
Yoshikawa
T
T
Ogura
A
A
Kawahara
T
T
Inoue
T
T
Ogawa
R
R
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D012018:Reflex / Q000187:drug effects*; D013610:Tachycardia / Q000139:chemically induced
D008012:Lidocaine