title: Locomotor and exploratory activity in three inbred strains of mice from young adulthood to senescence.
abstract: Nine variables measuring activity and exploratory behavior were collected for nine independent groups of three inbred strains of mice (BALB/c, C57BL/6, and DBA/2) at three ages (150, 400, and 750 days). An analysis of variance measuring differences of performances and a covariance analysis estimating the evolution of scores with age shows that (1) some variables are unaffected by age; (2) a strain-age interaction is observed for some variables; (3) some groups do not exhibit any age-related change for certain variables; and (4) the level of ability of age-related behavior varies across groups. These data argue for rejection of a general factor of aging and suggest that we are dealing with two distinct phenotypes: performance, and age-related modification of the performance, which therefore are not linked.
authors.affiliation: Laboratoire Génétique, Neurogénétique et Comportement, Université Paris V, France.
authors.forename: L
authors.initials: L
authors.lastname: Lhotellier
authors.forename: F
authors.initials: F
authors.lastname: Perez-Diaz
authors.forename: C
authors.initials: C
authors.lastname: Cohen-Salmon
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D005106:Exploratory Behavior; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C / Q000502:physiology*; D008810:Mice, Inbred C57BL / Q000502:physiology*; D008811:Mice, Inbred DBA / Q000502:physiology*; D009043:Motor Activity; D012044:Regression Analysis