Cardiovascular and pulmonary effects of betamethasone during midtrimester on fetal rats.
In order to elucidate the effects of corticosteroids on fetal hearts during midtrimester, pregnant rats were injected with a daily dose of betamethasone (1 mg/kg) from the 12th day through the 17th day of pregnancy. The fetal cardiovascular and pulmonary systems were studied on the 21st day of pregnancy (term). The treated fetuses showed the following signs of hydrops fetalis: retarded growth, pale, edematous skin, and decreased movement. The thymus and lung displayed prominent hypoplasia. The morphometry of the treated fetuses revealed: decreased right ventricle mass by 37% and decreased left ventricle mass by 29%. We concluded betamethasone had a significant effect on the developing fetal cardiovascular system, inducing hydrops fetalis. Additionally, beta-methasone caused hypoplasia of the thymus and lung.
Wu
F F
FF
Department of Pediatric Cardiology, Tokyo Women's Medical College, Japan.
Momma
K
K
Takao
A
A
D000818:Animals; D001623:Betamethasone / Q000494:pharmacology* / Q000633:toxicity; D002319:Cardiovascular System / Q000187:drug effects / Q000196:embryology*; D005260:Female; D005865:Gestational Age; D006321:Heart / Q000187:drug effects / Q000196:embryology; D015160:Hydrops Fetalis / Q000139:chemically induced; D008168:Lung / Q000187:drug effects / Q000196:embryology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000187:drug effects / Q000196:embryology
D001623:Betamethasone