title: Short communication: adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma.
abstract: Of five patients with epidermoid carcinoma of the lung who were treated with small fields of 80 Gy in 40 fractions/8-11 weeks (TDF123-129) to the hilar region, four patients developed marked stenosis of the proximal bronchi without tumour progression and died of pulmonary insufficiency 1-3 years after radiotherapy. These results should serve as a warning against escalation of the radiation dose, and the upper optimal dose might prove to be less than 80 Gy for the treatment of pulmonary hilar lesions.
authors.affiliation: Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: N
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
authors.forename: H
authors.initials: H
authors.lastname: Niibe
mesh_terms: D000368:Aged; D001980:Bronchi / Q000528:radiation effects*; D016084:Bronchoconstriction; D002283:Carcinoma, Bronchogenic / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D011879:Radiotherapy Dosage; D012131:Respiratory Insufficiency / Q000209:etiology