[Study on hydrolytic kinetics of metronidazole-phosphate in rabbit plasma by HPLC].
A HPLC method for the simultaneous determination of metronidazole and metronidazole-phosphate in rabbit plasma has been established. This method is simple, sensitive, reproducible and has a good linearity. It has been used to study the hydrolytic kinetics of metronidazole-phosphate in rabbit plasma. The results show that hydrolytic process of metronidazole-phosphate in vitro at 37 degrees C follows a first order kinetics with the rate constant 0.016 min-1 and half-life 43 min.
Qu
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S
Li
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T
Liu
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S
Yan
Y
Y
Chen
X
X
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D007700:Kinetics; D008795:Metronidazole / Q000031:analogs & derivatives / Q000097:blood*; D011817:Rabbits; D012995:Solubility
D008795:Metronidazole