title: Ileal pouch arthritis.
abstract: The association between arthritis and intestinal inflammation is well established, but the pathogenesis of the inflammatory joint disease remains speculative. We report six patients who developed a polyarthritis following restorative proctocolectomy with an ileal pouch-anal anastomosis (IPAA) for extensive ulcerative colitis between 1983 and 1990. Six patients were identified with no complaint of joint symptoms before surgery. The average time to onset of arthritis following surgery was 8 months (1 week-yr). The typical features were of an acute symmetrical polyarthritis involving the peripheral and axial skeleton. Early morning stiffness was pronounced in two and minimal in the rest. Three patients were treated with a course of prednisolone and remain in remission (1-4 yr). We believe that this is a novel form of arthritis clearly linked to pouch surgery which may provide important clues to the role of gastrointestinal antigens in rheumatic diseases.
authors.affiliation: Department of Rheumatology, St Bartholomew's Hospital, London.
authors.forename: J M
authors.initials: JM
authors.lastname: Axon
authors.forename: P R
authors.initials: PR
authors.lastname: Hawley
authors.forename: E C
authors.initials: EC
authors.lastname: Huskisson
mesh_terms: D000328:Adult; D001168:Arthritis / Q000188:drug therapy / Q000209:etiology*; D003093:Colitis, Ulcerative; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*
chemical_list: D011239:Prednisolone