[Expression and function of cardiovascular local renin-angiotensin system].
Cardiovascular renin-angiotensin system plays an important roll in physiological and pathological status. Its autocrine and paracrine functions are to regulate vascular tone, cardiac contractility and to regulate cardiac and vascular growth. It is well known that systemic hypertension induces cardiac hypertrophy, and it can be prevented by antihypertensive drugs. But its mechanism is still unclear. In our study all antihypertensive drugs could prevent left ventricular hypertrophy of genetic hypertension model SHR. Left ventricular Angiotensinogen m-RNA expression of SHR was 2 fold higher than WKY's. All antihypertensive drugs could also prevent left ventricular angiotensinogen m-RNA expression. It is suggested that mechanism of left ventricular hypertrophy which is induced by systemic hypertension is related with cardiac angiotensinogen m-RNA expression. And it can be modulated by any kind of antihypertensive drug treatments.
Kudou
T
T
Cardiovascular medicine of Hokkaido University.
Kawaguchi
H
H
Okamoto
H
H
Kitabatake
A
A
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012084:Renin-Angiotensin System / Q000502:physiology*