[Accumulation of hydroxylated PCB metabolites in blood].
In order to investigate some potential accumulate properties of hydroxylated PCB metabolites, blood and tissues such as livers, kidneys, lungs and adipose tissue from rats exposed to a commercial PCB (Aroclor 1254) were analyzed for hydroxylated PCBs (OH-PCBs). A large number of OH-PCBs were detected in the liver 1 day after exposure among which almost 13 have been identified in the blood. OH-PCBs were retained selectively in the blood probably due to binding between the OH-PCBs and a protein in serum. One major OH-PCB determined in rat blood was 4-OH-2', 3, 3', 4', 5-pentaCB formed from 2, 3, 3', 4, 4'-pentaCB after NIH shift. Blood of a grey seal from the Baltic also contained at least 8 OH-PCB congeners with 2 major compounds determined as 4-OH-2', 3, 3', 4', 5-pentaCB and 4-OH-2, 3, 3', 4', 5, 5'-hexaCB. Thus, 4-OH-2', 3, 3', 4', 5-pentaCB is the most retainable OH-PCB congener in blood from rats and seal. Human serum have also been found to contain a few number of OH-PCBs at concentration of 0.6 ng/g serum which corresponds to one fourth of PCB level.
Kuroki
H
H
Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
Haraguchi
K
K
Saito
H
H
Masuda
Y
Y
Wehler
E K
EK
Bergman
A
A
D000818:Animals; D001140:Aroclors / Q000493:pharmacokinetics / Q000506:poisoning; D020111:Chlorodiphenyl (54% Chlorine); D004785:Environmental Pollutants / Q000097:blood; D006801:Humans; D008297:Male; D010636:Phenols / Q000097:blood*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D046048:Seals, Earless / Q000097:blood
D001140:Aroclors; D004785:Environmental Pollutants; D010636:Phenols; D020111:Chlorodiphenyl (54% Chlorine); D011078:Polychlorinated Biphenyls