title: Acute encephalopathy, hypertension and gram negative sepsis in sickle cell disease.
abstract: The case histories of two patients with sickle cell disease and gram negative sepsis complicated by encephalopathy and hypertension is presented. The first patient had 2 episodes of "hypertensive encephalopathy" before control of her blood pressure was achieved while the second patient had only one. The occurrence, though apparently rare, can have serious implications. Possible mechanisms are discussed and the need to monitor the blood pressure of children with sickle cell disease is stressed.
authors.affiliation: Department of Paediatrics, College of Medical Sciences, Borno State, Nigeria.
authors.forename: G O
authors.initials: GO
authors.lastname: Akpede
authors.forename: A I
authors.initials: AI
authors.lastname: Airede
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications*; D016470:Bacteremia / Q000097:blood / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D001794:Blood Pressure; D002648:Child; D003128:Coma / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy