title: [Sarcomatous degeneration in Paget disease of bone. Apropos of a clinical case].
abstract: Sarcomatous degeneration is the most dreaded complication of Paget's disease of bone: this case report offers an opportunity for underlining the difficulties of differential diagnosis in a case of pulmonary metastatization in the presence of osteitis deformans. Immunohistochemical assay applied to the cytology of pulmonary needle-aspiration and surgical biopsy targeted to the suspected neoplastic lesion allowed correct diagnosis. This case confirms the very poor prognosis of this kind of neoplasm: the rapidity of the fatal outcome was not significantly influenced even by the most aggressive polychemotherapy. This poor prognosis appears to be related to a more aggressive growth of the neoplasm and to the reduced immunologic resistance of the elderly.
authors.affiliation: II Divisione di Medicina, Ospedale di Saronno.
authors.forename: L
authors.initials: L
authors.lastname: Banfi
authors.forename: G
authors.initials: G
authors.lastname: Corbella
authors.forename: F
authors.initials: F
authors.lastname: Guzzini
authors.forename: M
authors.initials: M
authors.lastname: Ceppi
mesh_terms: D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging* / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011379:Prognosis; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed
vernacular_title: Degenerazione sarcomatosa nella malattia ossea di Paget. A proposito di un caso clinico.