Age-related nonrandom chromosomal abnormalities in human low-grade astrocytomas.
We report a cytogenetic investigation of 55 low-grade astrocytomas in 52 patients, 15 children and 37 adults. In addition to numerical aberrations such as trisomy 7 and gonosomal losses, we found structural and/or numerical aberrations of chromosome 1 in eight astrocytomas. There was a striking difference between the rearranged chromosomes in pediatric and adult patients. Whereas the pediatric tumors revealed monosomies 1p with accompanying trisomy 1q, the astrocytomas in adults showed partial or complete monosomies 1q.
Thiel
G
G
Institut für Medizinische Genetik der Medizinischen Fakultät (Charité) der Humboldt-Universität zu Berlin.
Lozanova
T
T
Vogel
S
S
Kintzel
D
D
Jänisch
W
W
Witkowski
R
R
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001254:Astrocytoma / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D014314:Trisomy