title: Transcranial Doppler ultrasonography in senile dementia: neuropsychological correlations.
abstract: Blood flow velocities were measured in right and left middle cerebral arteries (MCAs) and in basilar artery (BA) on rest conditions by transcranial Doppler ultrasonography in three groups of patients: a) Alzheimer's disease patients (AD, N = 12, age = 63.5 +/- 6.6 years), b) patients with multi-infarct dementia (MID, N = 12, age = 72.8 +/- 9.0 years), and c) control subjects (CS, N = 12, age = 57.20 +/- 7.5 years). TCD measures were taken through the temporal window for MCA recordings, and transforaminal approach for BA recordings, with a 2 MHz ultrasonic probe using a TC-2000S (EME). A significantly (p < 0.05) decrease in TCD measures was found in right and left MCA and BA of dementia patients with respect to controls. Data analysis included a significant correlation between blood flow velocities and Hachinski scores (p < 0.016) in multi-infarct dementia patients. These results appear to show a general hypoperfusion pattern in the brain of senile dementia patients.
authors.affiliation: Department of Digital Diagnosis, Basic and Clinical Neurosciences Research Center, La Coruña, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Caamaño
authors.forename: M J
authors.initials: MJ
authors.lastname: Gómez
authors.forename: R
authors.initials: R
authors.lastname: Cacabelos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D001488:Basilar Artery / Q000000981:diagnostic imaging / Q000502:physiology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D003704:Dementia / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology*; D015161:Dementia, Multi-Infarct / Q000000981:diagnostic imaging / Q000503:physiopathology; D004453:Echoencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014655:Vascular Resistance / Q000502:physiology