[Changes in the level of cyclic nucleotides in the left and right sensorimotor areas of the cerebral cortex in rats after corazol-induced kindling].
Levels of cAMP and cGMP in the left and right areas of the rat sensorimotor cortex (SMC) 7 days after pentylenetetrazole kindling (30 days) were determined by radioimmunological assay. It is shown that levels of cyclic nucleotides remained unchanged in rats SMC 7 days after single injection of seizure dose (70 mg/kg) of pentylenetetrazole. Levels of cAMP and cGMP in SMC increased by 2-3 times after 30-day administration of physiological saline as compared to single injection; cortical asymmetry of cAMP and cGMP is absent. Differences in the levels of cyclic nucleotides in sensitive and low-sensitive animals to pentylenetetrazole were not revealed. When kindling was completed cGMP level increased in right SMC and it decreased in left SMC as compared to control animals; cAMP level was unaltered in left and increased in right SMC. The role of cortical asymmetry of cyclic nucleotides development of seizure state is discussed.
Glebov
R N
RN
Karpova
M N
MN
Goriacheva
T V
TV
Mikhal'skaia
I O
IO
Spasskaia
M E
ME
Pankov
O Iu
OIu
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004292:Dominance, Cerebral / Q000187:drug effects* / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009044:Motor Cortex / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000242:Cyclic AMP; D006152:Cyclic GMP; D010433:Pentylenetetrazole
Izmeneniia urovenia tsiklicheskikh nukleotidov v levoĭ i pravoĭ sensomotornoĭ oblasti kory mozga krys posle korazolovogo kindlinga.