Studies on the renal excretion of the acyl glucuronide, phenolic glucuronide and sulphate conjugates of diflunisal.
1. In five healthy male volunteers given multiple doses of diflunisal (DF), renal clearances (CLR) of the acyl glucuronide (DAG), phenolic glucuronide (DPG) and sulphate (DS) conjugates were about 42, 25 and 13 ml min-1, respectively. 2. These relatively low CLR values are probably due largely to the very high plasma protein binding of the conjugates, found in vitro to be 99.0%, 97.8% and 99.45%, respectively. 3. Thus glomerular filtration plays the minor and active tubular secretion the major role in renal excretion of the three conjugates. 4. This conclusion was supported by the effect of probenecid co-administration, which decreased CLR of DAG and DPG by about 70%. CLR for DS could not be calculated when probenecid was co-administered (because of interference by probenecid metabolites in the analysis of DS in urine). 5. Water-induced diuresis had no effect on CLR of the DF conjugates, consistent with tubular reabsorption being negligible.
Dickinson
R G
RG
Department of Medicine, University of Queensland, Brisbane, Australia.
King
A R
AR
McKinnon
G E
GE
Hooper
W D
WD
Eadie
M J
MJ
Herkes
G K
GK
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D004061:Diflunisal / Q000097:blood / Q000494:pharmacology / Q000652:urine*; D004231:Diuresis / Q000187:drug effects; D004326:Drinking; D004347:Drug Interactions; D005965:Glucuronates / Q000652:urine; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000652:urine; D011339:Probenecid / Q000494:pharmacology; D011485:Protein Binding; D013431:Sulfates / Q000652:urine
D001798:Blood Proteins; D005965:Glucuronates; D010636:Phenols; D013431:Sulfates; D004061:Diflunisal; D011339:Probenecid