title: Successful childbirth by a patient with congenital factor XI deficiency and an acquired inhibitor.
abstract: Acquired inhibitors in factor XI deficiency (FXI) are rare. The presence of an inhibitor during pregnancy poses a potential haemorrhagic risk to the fetus. We report an uncomplicated pregnancy and successful childbirth by a woman with congenital FXI deficiency and an acquired inhibitor, and discuss the persistence of residual FXI activity in the presence of an inhibitor.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: S S
authors.initials: SS
authors.lastname: Ginsberg
authors.forename: L P
authors.initials: LP
authors.lastname: Clyne
authors.forename: P
authors.initials: P
authors.lastname: McPhedran
authors.forename: T P
authors.initials: TP
authors.lastname: Duffy
authors.forename: T
authors.initials: T
authors.lastname: Hanson
mesh_terms: D000328:Adult; D002585:Cesarean Section; D005172:Factor XI / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005173:Factor XI Deficiency / Q000097:blood*; D005260:Female; D006801:Humans; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*
chemical_list: D005172:Factor XI