Trends in peptic ulcer mortality in Sydney from 1971 to 1987.
Gastric and duodenal ulcer (GU,DU) mortality in Western countries has varied over time by age and sex. Temporal variation raises the question of whether these ulcers have an environmental etiology. Using death certificate data, we investigated peptic ulcer mortality time trends from 1971 to 1987 in Sydney, Australia, and whether ulcer mortality and overall mortality in Sydney were similar with regard to time trends and associations with demographic and environmental factors. In men in all age groups and in women age < 65, GU and DU mortality decreased. In women age > or = 70, GU mortality remained constant and DU mortality increased. Average age at ulcer death increased: from 1971 to 1987, ulcer deaths at age > or = 70 rose from 52 to 80% of all ulcer deaths. In men who died at age 30-54, GU and DU mortality decreased relative to overall mortality. In women who died at age > or = 55, DU mortality increased relative to overall mortality. Compared with overall mortality, the ulcer mortality rate was affected more adversely by lower social class and lack of the marriage tie, and smoking rates tended to correlate more strongly with GU mortality. The greater-than-expected decrease in GU and DU mortality in younger men and the increase in DU mortality in elderly women suggest important changes in as yet unidentified environmental risk factors for ulcer mortality within the young adult male and elderly female general populations.
McIntosh
J H
JH
Department of Medicine, University of Sydney, New South Wales, Australia.
Byth
K
K
Tsang
N
N
Berman
K
K
Holliday
F M
FM
Piper
D W
DW
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002423:Cause of Death; D003644:Death Certificates; D005260:Female; D006801:Humans; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D010437:Peptic Ulcer / Q000209:etiology / Q000401:mortality*; D012907:Smoking / Q000009:adverse effects; D012923:Social Class; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal