title: Metabolites of the plasticizer di(2-ethylhexyl)phthalate in urine samples of workers in polyvinylchloride processing industries.
abstract: Little is known about occupational exposure to the plasticizer di(2-ethylhexyl)phthalate (CAS number 117-81-7), a compound widely used in polyvinylchloride (PVC) plastics. We have studied the uptake of DEHP in workers by determining the concentrations of four metabolites of DEHP in urine samples, i.e., mono(2-ethylhexyl)phthalate (MEHP), mono(5-carboxy-2-ethylpentyl)phthalate, mono(2-ethyl-5-oxohexyl)phthalate, and mono(2-ethyl-5-hydroxyhexyl)phthalate. In addition DEHP concentrations in the air were determined by personal air sampling. Nine workers in a PVC boot factory exposed to a maximum of 1.2 mg/m3 DEHP showed an increase in the urinary concentrations of all four metabolites over the workshift. These results were obtained on both the first and the last day of the workweek. With the exception of MEHP, the increases in the concentrations of the metabolites during a workday were statistically significant. Six workers from a PVC cable factory exposed to a maximum of 1.2 mg/m3 DEHP showed a one- to fourfold increase in the concentrations of the four metabolites over the workshift, but these increases were not statistically significant. These results indicate that measurement of DEHP metabolites in urine samples may be of use for monitoring the occupational exposure to DEHP.
authors.affiliation: University of Nijmegen, Department of Toxicology, The Netherlands.
authors.forename: H A
authors.initials: HA
authors.lastname: Dirven
authors.forename: P H
authors.initials: PH
authors.lastname: van den Broek
authors.forename: A M
authors.initials: AM
authors.lastname: Arends
authors.forename: H H
authors.initials: HH
authors.lastname: Nordkamp
authors.forename: A J
authors.initials: AJ
authors.lastname: de Lepper
authors.forename: P T
authors.initials: PT
authors.lastname: Henderson
authors.forename: F J
authors.initials: FJ
authors.lastname: Jongeneelen
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000378:metabolism / Q000652:urine*; D002617:Chemical Industry; D004051:Diethylhexyl Phthalate / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D011143:Polyvinyl Chloride
chemical_list: D000395:Air Pollutants, Occupational; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate