title: Bilateral multicentric papillary renal tumors with heteroclonal origin based on tissue-specific karyotype instability.
abstract: BACKGROUND
  Papillary chromophilic renal tumors were cytogenetically characterized by combined trisomies 7 and 17 along with other numeric chromosome aberrations. They occurred as bilateral multifocal lesions.
  
  
  METHODS
  A patient was presented who simultaneously developed bilateral multicentric papillary renal tumors. Tissue specimens from six tumors and tumor-free kidneys were cytogenetically characterized.
  
  
  RESULTS
  The tumors showed trisomy of chromosomes 7, 16, and 17 along with various other numeric abnormalities. In normal tissue from both kidneys, a wide variety of clonal and nonclonal numeric and structural chromosome aberrations were found.
  
  
  CONCLUSIONS
  The cytogenetic heteroclonality of the tumors strongly favors the assumption that they arose as independent primaries. A tissue-specific karyotype instability may be the basic event of multiple tumorigenesis.
authors.affiliation: Department of Human Genetics, University of Saarland, Homburg/Saar, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Henn
authors.forename: T
authors.initials: T
authors.lastname: Zwergel
authors.forename: B
authors.initials: B
authors.lastname: Wullich
authors.forename: M
authors.initials: M
authors.lastname: Thönnes
authors.forename: K D
authors.initials: KD
authors.lastname: Zang
authors.forename: G
authors.initials: G
authors.lastname: Seitz
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology / Q000601:surgery