Tianeptine raises dopamine and blocks stress-induced noradrenaline release in the rat frontal cortex.
The effects of various doses of tianeptine on extracellular concentrations of dopamine were studied in the frontal cortex and nucleus accumbens of the rat. At 5 and 10 mg/kg intraperitoneally, tianeptine raised extracellular dopamine in the nucleus accumbens but only the higher dose caused a significant increase in the frontal cortex. At 10 mg/kg tianeptine significantly raised the concentrations of dihydroxyphenylacetic acid and homovanillic acid in both brain regions. In another experiment, 10 and 20 mg/kg tianeptine did not modify the extracellular concentrations of noradrenaline in the frontal cortex but dose dependently blocked the increase in extracellular noradrenaline caused by restraint stress.
Sacchetti
G
G
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Bonini
I
I
Waeterloos
G C
GC
Samanin
R
R
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006719:Homovanillic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013841:Thiazepines / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid