[An investigation of the effect of rostral ventrolateral medulla lesion on pressor response induced by electrical stimulation of hypothalamic paraventricular nucleus in the cat].
The experiments were performed on 20 adult cats anesthetized with chloralose and urethane, paralyzed and artificially ventilated. The rostral ventrolateral medulla (RVL) was explored by electrical stimulation. We found that an area, 3-5 mm rostral to the obex, 3-4 mm lateral to the midline, and 0-1 mm from the ventral surface of the medulla, was the most effective region for producing a pressor response. After bilateral microinjection of kainic acid into or electrolytic lesion of the above-mentioned active RVL area, a large decrease in arterial blood pressure was elicited, and the pressor response induced by electrical stimulation of the hypothalamic paraventricular nucleus (PA) was nearly eliminated. The results suggest that the RVL mediates the PA pressor response.
Qi
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J
Xu
M
M
Lu
Z
Z
D000818:Animals; D001794:Blood Pressure; D002415:Cats; D004558:Electric Stimulation; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology*
D007608:Kainic Acid