[The efficacy of phenol antioxidants in vitro and in vivo].
The antioxidative activity of ionol, 2,2'methylene-bis(6-tert-butyl-4-methylphenol), 2,2-ethylenebis (6-tert-butyl-4-methylphenol), 2,2-propylenebis (6-tert-butyl-4-methylphenol, 2,2-butylenebis (6-tert-butyl-4-methylphenol) was studied in models and in albino rats with experimental hyperthyroidism. The most intensive extinguishing of induced chemiluminescence was found to be produced by 2,2-methylenebis (6-tert-butyl-4-methylphenol) and 2,2-ethylenebis (6-tert-butyl-4-methylphenol). These substances produced the most inhibitory effects on lipid peroxidation in the heart of hyperthyroidism animals.
Vadziuk
S N
SN
Gorodetskiĭ
I T
IT
Faĭfura
V V
VV
Klishch
I N
IN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects; D006980:Hyperthyroidism / Q000188:drug therapy / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008163:Luminescent Measurements; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D000975:Antioxidants; D010636:Phenols
Effektivnost' fenol'nykh antioksidantov in vitro i in vivo.