[Pharmacokinetics model for targeted drug delivery systems].
Analyzing the observed phenomena and the data collected in research, we developed a multi-compartment linear recirculation model for targeted drug delivery systems and figured out the function formulas of the drug concentration-time in blood and target organ by computing. According to this model, the drug concentration-time curve for the target organ can be plotted with reference to the data on blood; the pharmacokinetics parameters of the target organ can also be obtained. We further detected the practicability of the model by using the curves of drug concentration-time in blood and target organ (liver) of liver-targeting nanoparticles obtained from animal tests. Based on the liver drug concentration-time curve calculated by the function formula of target organ and the statistical moment, the pharmacokinetics behaviour of the target organ (liver) was analysed and the pharmacokinetics parameters of liver were obtained. We suggest that the "relative targeting index" be used for quantitative evaluation of the targeted drug delivery system.
Zhang
Z
Z
Liao
G
G
Liu
P
P
D000818:Animals; D016503:Drug Delivery Systems; D008099:Liver / Q000378:metabolism; D008433:Mathematics; D051379:Mice; D008956:Models, Chemical; D010599:Pharmacokinetics; D051381:Rats