title: The anti-metastatic effect of intravenously-inoculated BCG on prostate tumor cells.
abstract: The complication of metastasis from the primary tumor site to the distant organ is difficult to control. Tumor cells usually spread through the vascular system: lymphatics and/or blood; or by direct extension into adjacent sites. Transplantable prostate adenocarcinoma (PA-III) cells in L-W rats produces a tumor in the implant site and then spreads via the ipsilateral lymphatic route to the lungs in which new visible tumors develop. Viable bacillus Calmette-Guerin (BCG) was inoculated SC or IV into rats which were then inoculated either SC or IV with PA-III cells. They were examined thereafter for primary and for lung tumors. IV-inoculated BCG generated a strong intravascular intervention mechanism on metastatic PA-III cells in L-W rats. This immobilization mechanism was not demonstrable in rats that had been inoculated SC with BCG.
authors.affiliation: Lobund Laboratory, University of Notre Dame, IN 46556.
authors.forename: M
authors.initials: M
authors.lastname: Pollard
authors.forename: P H
authors.initials: PH
authors.lastname: Luckert
mesh_terms: D000230:Adenocarcinoma / Q000517:prevention & control* / Q000556:secondary; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008297:Male; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001500:BCG Vaccine