A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.
A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its intron/exon structure was determined and shown to be conserved with all other members of the cytokine receptor family. The physical distance between the CRF2-4 gene and its IFNAR neighbor has been narrowed to less than 35 kb.
Lutfalla
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G
Laboratory of Viral Oncology, IRSC, CNRS, Villejuif, France.
Gardiner
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K
Uzé
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G
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002891:Chromosomes, Human, Pair 21; D004247:DNA / Q000235:genetics; D005091:Exons; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D053710:Interleukin-10 Receptor beta Subunit; D008562:Membrane Glycoproteins; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D017433:Protein Structure, Secondary; D018121:Receptors, Cytokine; D011971:Receptors, Immunologic / Q000235:genetics*; D017471:Receptors, Interferon / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
C081846:IL10RB protein, human; D053710:Interleukin-10 Receptor beta Subunit; D008562:Membrane Glycoproteins; D018121:Receptors, Cytokine; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D004247:DNA