[The effect of blocking the reticuloendothelial system on the metabolism of low density lipoproteins in rabbits].
Intravenous ethyl oleate-induced blockade of the reticulo-endothelial apparatus (REA) in rabbits was found to reduce the elimination rate of both native and 125I-modified (acetylated) low lipoproteins. Lower lipoprotein catabolism is likely to result in hyperlipidemia observed in REA blockade. At the same time the latter was shown to induce the changes in low lipoproteins, which diminished their capacity to interact with fibroblasts, on the one hand, and to stimulate their macrophage uptake.
Denisenko
A D
AD
Vinogradov
A G
AG
Pivovarova
Iu I
IuI
Kuznetsov
A S
AS
Klimov
A N
AN
D000818:Animals; D007457:Iodine Radioisotopes / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D009829:Oleic Acids / Q000494:pharmacology; D011817:Rabbits
D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL; D009829:Oleic Acids; C033180:ethyl oleate
Vliianie blokady retikuloéndotelial'noĭ sistemy na metabolizm lipoproteinov nizkoĭ plotnosti u krolika.