title: [Perioperative perfusion in children: evaluation of a new perfusion solution].
abstract: A new intravenous solution (B66) containing 0.9% dextrose in water for infusion therapy in infants and children was assessed. Forty-one children, aged between 6 months and 11 years, scheduled for elective non haemorrhagic surgery, were randomly assigned to two groups: children in group I (n = 22) were given 1% dextrose in lactated Ringer's solution (RLG1), and those in group II (n = 19) the commercially available solution B66 (0.9% dextrose in lactated Ringer's solution). The fluids were administered throughout the study with volumetric infusion pumps (IVAC 541). The infusion rate was adapted to children's weight and age. Blood samples for blood glucose, sodium and protein concentration assessments were obtained at induction (T0), on arrival in the recovery room (T1), than 30 and 60 min later (T2 and T3). Preoperative blood glucose concentrations were within the normal range for all children except for two, who had asymptomatic hypoglycaemia (2.2 and 2.3 mmol.l-1). Postoperative blood glucose concentrations were higher in both groups. This increase was significantly greater in the RLG1 group than in the B66 group. The highest mean figures at T1 were 6.8 +/- 1.5 mmol.l-1 and 5.2 +/- 1.0 mmol.l-1 in the RLG1 and B66 groups respectively. Total protein levels decreased postoperatively significantly in both groups. Preoperative age-related differences in total protein concentrations were also observed postoperatively. Sodium concentrations remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Département d'Anesthésie-Réanimation Chirurgicale, Hôpital Saint-Vincent-de-Paul, Paris.
authors.forename: I
authors.initials: I
authors.lastname: Geib
authors.forename: M C
authors.initials: MC
authors.lastname: Dubois
authors.forename: L
authors.initials: L
authors.lastname: Gouyet
authors.forename: I
authors.initials: I
authors.lastname: Murat
authors.forename: C
authors.initials: C
authors.lastname: Saint-Maurice
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D007552:Isotonic Solutions / Q000008:administration & dosage*; D011184:Postoperative Period; D011897:Random Allocation; D012964:Sodium / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D007552:Isotonic Solutions; D012964:Sodium
vernacular_title: Perfusion périopératoire chez l'enfant: évaluation d'un soluté de perfusion.