Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth.
The effects of the flavonoid quercetin on cell proliferation and voltage-dependent K+ current were studied on mouse neuroblastoma x glioma hybrid cells. In the presence of 1% fetal calf serum, quercetin inhibited both cell proliferation and K+ current with effective doses inducing half-maximum effects of 10 microM and 70 microM respectively. Valinomycin (1 nM) antagonized 80% of the growth-inhibitory effects of 10 microM quercetin. The results suggest that at least a part of the anti-proliferative effect of quercetin is mediated by a K+ channel blockade. They further confirm a role for K+ channels in mitogenesis and cell proliferation.
Rouzaire-Dubois
B
B
Laboratoire de Physiologie Cellulaire, URA CNRS 1121, Orsay, France.
Gérard
V
V
Dubois
J M
JM
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004553:Electric Conductivity; D005312:Fetal Blood; D005910:Glioma / Q000473:pathology; D006822:Hybrid Cells; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011794:Quercetin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014634:Valinomycin / Q000494:pharmacology
D015221:Potassium Channels; D014634:Valinomycin; D000255:Adenosine Triphosphate; D004247:DNA; D011794:Quercetin