title: Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus.
abstract: OBJECTIVE
  To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE).
  
  
  METHODS
  TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects.
  
  
  RESULTS
  No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgroup of SLE. Furthermore, there was no evidence for significant linkage disequilibrium between TAP2 and HLA-DQ/DR in SLE.
  
  
  CONCLUSIONS
  These data suggest that TAP2 is not a disease susceptibility gene for SLE and that the disease-predisposing haplotypes do not extend as far as TAP2. This indicates that any HLA-DP association with SLE must be independent of other class II (DQ/DR) associations.
authors.affiliation: University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford.
authors.forename: E J
authors.initials: EJ
authors.lastname: Davies
authors.forename: R P
authors.initials: RP
authors.lastname: Donn
authors.forename: M C
authors.initials: MC
authors.lastname: Hillarby
authors.forename: D M
authors.initials: DM
authors.lastname: Grennan
authors.forename: W E
authors.initials: WE
authors.lastname: Ollier
mesh_terms: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics*; D004198:Disease Susceptibility; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D000949:Histocompatibility Antigens Class II; C071692:TAP2 protein, human