[Ovulation induction using pulsatile GnRH in patients with hypothalamic amenorrhea: effects of changing the frequency and dosage on the luteal phase].
Effects of frequency and dose variation of GnRH administration by minipumps Zyklomat, were studied in five women during luteal phase. As controls were assumed the same patients; in fact they had been previously treated with pulsatile GnRH with constant dose and frequency all over the cycle. Then the patients received the same treatment but the dose and the frequency of infusion were changed in the luteal phase. Our data show an increase of mean levels of progesterone and oestradiol during the luteal phase and a better pregnancy rate when the frequency and the dose of GnRh administration were changed.
Vizziello
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Istituto di Ricovero e Cura a Carattere Scientifico S. De Bellis, Castellana Grotte Bari.
D'Amato
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Trentadue
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Fanizza
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D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy* / Q000209:etiology; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000172:deficiency / Q000494:pharmacology; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications; D007260:Infusion Pumps; D008183:Luteal Phase / Q000187:drug effects*; D008473:Median Eminence; D010062:Ovulation Induction; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol
Induzione dell'ovulazione con GnRH pulsatile in soggetti affetti da amenorrea ipotalamica: effetti della modificazione della frequenza e del dosagio sulla fase luteale.