[The pharmacokinetics of a new anti-arrhythmic substance, Z-2-amino-5-chlorobenzophenoneamidinohydrazone (AWD-G256)].
In 4 studies blood levels and metabolites of Z-2-amino-5-chlorobenzophenoneamidinohydrazoneacetate (AWD-G256) after different dosages and forms of application on patients and healthy volunteers were investigated. In addition the pharmacokinetic parameters were calculated. The determination of pharmacokinetic parameters was possible only after i.v. application of dosages higher than 0.30 mg.kg-1 b.m. as well as p.o. administration of dosages higher than 100 mg. The blood level curve after i.v. application demonstrated a 2-compartment model and after p.o. application a 1-compartment model. Exact pharmacokinetic data can't be clear estimated with this studies.
Farker
K
K
Institut für Klinische Pharmakologie, Friedrich-Schiller-Universität Jena.
Henschel
L
L
Marschner
J P
JP
Reimann
I
I
Volkmann
H
H
Hoffmann
A
A
D000284:Administration, Oral; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001577:Benzophenones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D006835:Hydrazones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
D000889:Anti-Arrhythmia Agents; D001577:Benzophenones; D006835:Hydrazones; C080444:(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate
Untersuchungen zur Pharmakokinetik der neuen antiarrhythmischen Substanz Z-2-Amino-5-chlorbenzophenonamidinohydrazonacetat (AWD-G256).