Norethindrone alters apolipoprotein E concentration and isoform expression in rat plasma high-density lipoproteins.
The administration of norethindrone, a synthetic progestin, to female rats caused marked decreases in the cholesterol and protein contents of high-density lipoproteins (HDL). A 84% decrease in the total apolipoprotein (apo) E of HDL was associated with a 80% decrease in the proportions of apoE isoforms E1 and E2, whereas E3 and E4 were unchanged. This appears to be the first demonstration of hormonally-induced modification of the apoE phenotype.
Valette
A
A
INSERM U. 260, Faculté de Médecine, Marseille, France.
Mercier
L
L
Vérine
A
A
Delpéro
C
C
Boyer
J
J
D000818:Animals; D001057:Apolipoproteins E / Q000097:blood / Q000187:drug effects*; D005260:Female; D007525:Isoelectric Focusing; D008075:Lipoproteins, HDL / Q000097:blood*; D009640:Norethindrone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001057:Apolipoproteins E; D008075:Lipoproteins, HDL; D009640:Norethindrone