title: Acetylation phenotypes and environmental chemical exposure of people with idiopathic systemic lupus erythematosus.
abstract: OBJECTIVE
  To test the hypotheses that there is an excess percentage of slow acetylators among patients with idiopathic systemic lupus erythematosus (SLE) and that these patients had excessive exposure to environmental amines and hydrazines before the onset of illness.
  
  
  METHODS
  Case-control study with structured interview and acetylation phenotyping.
  
  
  RESULTS
  No excess proportion of slow acetylators or environmental amine exposure was found.
  
  
  CONCLUSIONS
  Slow acetylation phenotype and exposure to environmental amines are not principal causes of idiopathic SLE.
authors.affiliation: Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
authors.forename: M M
authors.initials: MM
authors.lastname: Reidenberg
authors.forename: D E
authors.initials: DE
authors.lastname: Drayer
authors.forename: B
authors.initials: B
authors.lastname: Lorenzo
authors.forename: B L
authors.initials: BL
authors.lastname: Strom
authors.forename: S L
authors.initials: SL
authors.lastname: West
authors.forename: E S
authors.initials: ES
authors.lastname: Snyder
authors.forename: B
authors.initials: B
authors.lastname: Freundlich
authors.forename: P D
authors.initials: PD
authors.lastname: Stolley
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000328:Adult; D000588:Amines / Q000494:pharmacology*; D003622:Dapsone / Q000008:administration & dosage; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012907:Smoking / Q000009:adverse effects
chemical_list: D000588:Amines; D006834:Hydrazines; D003622:Dapsone