[Ocular complications of intracarotid chemotherapies with nitrosourea agents].
The authors report ocular complications in intracarotid chemotherapy with Nitrosyl-urea on 39 patients with intracerebral malignant tumor (anaplastic astrocytoma). Internal carotid infusion catheter was in infra-ophthalmic position. They also report 13 ocular complications (33% of cases) as arterial retinal occlusions essentially, ipsilateral to catheter site. Their study and literature revue emphasize five ocular toxicity factors; intracarotid catheter position, type of drug, its quantity, its solubility and solvent, the rate of infusion.
Rigal-Sastourne
J C
JC
Clinique d'Ophtalmologie, Hôpital d'Instruction des Armées du Val de Grâce, Paris.
Bidaux
F
F
Mir
F
F
Crepy
P
P
Lucas
B
B
Renard
J P
JP
Derosier
C
C
Maurin
J F
JF
Bourgeois
H
H
D000328:Adult; D000368:Aged; D002343:Carotid Artery, Internal; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D012164:Retinal Diseases / Q000139:chemically induced
D009607:Nitrosourea Compounds
Complications oculaires des chimiothérapies intracarotidiennes par nitroso-urées.