title: Double lung transplantation for adult respiratory distress syndrome after recombinant interleukin 2.
abstract: Patients suffering from acute respiratory failure are considered poor candidates for lung transplantation (LT). We report a successful double lung transplantation performed in a patient with adult respiratory distress syndrome (ARDS). The 32-year-old woman received recombinant interleukin 2 (rIL-2) three months after an autologous bone marrow transplant for acute myelogenic leukemia as consolidation treatment. After four days of treatment with rIL-2, she developed ARDS which worsened over a three-week period, despite treatment. Lung transplantation was carried out as ultimate treatment. The postoperative course was uneventful. The patient is alive and in a good condition 11 months after LT. This case demonstrates the feasibility of LT in selected patients with ARDS. However, this case is exceptional since lung grafts should be utilized preferably for evaluated and accepted patients in transplant programs.
authors.affiliation: Centre Hospitalier Universitaire de Grenoble, Université Joseph Fourier, France.
authors.forename: P Y
authors.initials: PY
authors.lastname: Brichon
authors.forename: D
authors.initials: D
authors.lastname: Barnoud
authors.forename: C
authors.initials: C
authors.lastname: Pison
authors.forename: I
authors.initials: I
authors.lastname: Perez
authors.forename: M
authors.initials: M
authors.lastname: Guignier
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D016040:Lung Transplantation; D011859:Radiography; D011994:Recombinant Proteins / Q000009:adverse effects; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins