Renal cell carcinoma with osteoclast-like giant cells.
Primary extraskeletal epithelial neoplasms with osteoclast-like giant cells are rare. We describe a case of renal cell carcinoma with a sarcomatoid component and non-neoplastic osteoclast-like giant cells. The giant cells were noted in both the conventional and the sarcomatoid components of the neoplasm. Immunohistochemical studies indicate that these cells are monocyte/histiocyte in origin and most probably a host stromal reaction to the neoplasm.
el-Naggar
A K
AK
Department of Pathology, M.D. Anderson Cancer Center, Houston, Texas.
Gaber
K
K
Ordonez
N G
NG
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology*; D010010:Osteoclasts / Q000473:pathology*
D007381:Intermediate Filament Proteins