title: Impaired fibrinolytic activity induced by ingestion of butter: effect of increased plasma lipids on the fibrinolytic activity.
abstract: To investigate the effects of the increased plasma lipid level on fibrinolysis, we measured the levels of fibrinolytic components in serially obtained plasma samples from healthy volunteers after the intake of different amounts of butter. Plasma triglyceride level increased significantly after butter intake compared to the control group. Eight hours after the intake of 100g of butter, plasminogen activator inhibitor 1 (PAI-1) level in plasma was significantly higher and euglobulin clot lysis time was significantly prolonged compared to those of the control group. There was no effect on plasma tissue plasminogen activator level. These results suggest that the temporary increase in plasma triglyceride level induced high PAI-1 level, resulting in impaired fibrinolytic activity. The effect of temporary hyperlipidemia on platelet function was also analyzed and revealed that the response of platelets to ADP and collagen was lower in the butter intake group compared to those of the control.
authors.affiliation: Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka-ken, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kozima
authors.forename: T
authors.initials: T
authors.lastname: Urano
authors.forename: K
authors.initials: K
authors.lastname: Serizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: A
authors.initials: A
authors.lastname: Takada
mesh_terms: D000293:Adolescent; D000328:Adult; D002079:Butter / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D010974:Platelet Aggregation / Q000187:drug effects; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides; D002079:Butter; D010959:Tissue Plasminogen Activator