title: Intrinsic effect of antihypertensive treatment with isradipine and metoprolol on large artery geometric and elastic properties.
abstract: The effects of isradipine and metoprolol were studied on the brachial arteries of two groups of 14 patients with hypertension, 90 minutes after the first dose and after 3 months of treatment. Diameter (pulsed Doppler) and compliance (pulse-wave velocity) were measured and calculated in isobaric conditions by way of a model that allowed discrimination of the active intrinsic drug action. Isradipine increased measured and isobaric diameter during short-term (p < 0.05) and long-term administration (p < 0.05), whereas metoprolol did not change it. Active diameter effects were different between drugs during short-term administration (p < 0.05). Isaradipine increased measured and isobaric compliance during short-term (p < 0.05) and long-term administration (p < 0.05). Short-term administration of metoprolol decreased measured compliance (p < 0.01). Metoprolol decreased isobaric compliance during short-term (p < 0.01) and long-term (p < 0.05) administration. Active compliance effects were different between drugs during short- and long-term administration (p < 0.01). These arterial intrinsic drug effects, independent of the pressure-lowering influence, suggested different mechanisms, consisting of a large artery smooth muscle relaxation for isradipine and an isometric arterial constriction for metoprolol.
authors.affiliation: Centre de Médecine Préventive Cardio-vasculaire, INSERM U 28, Hôpital Broussais, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Merli
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: M
authors.initials: M
authors.lastname: Del Pino
authors.forename: M
authors.initials: M
authors.lastname: Brautigam
authors.forename: D
authors.initials: D
authors.lastname: Welzel
authors.forename: J
authors.initials: J
authors.lastname: Levenson
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001916:Brachial Artery / Q000187:drug effects* / Q000503:physiopathology; D003187:Compliance / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D017275:Isradipine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008790:Metoprolol / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D008790:Metoprolol; D017275:Isradipine