Partial androgen insensitivity--are all tissues equal?
Nonaromatizable androgens, administered in high doses to an adult patient with partial androgen insensitivity, failed to result in a change in phallic size despite a clear decline in SHBG and gonadotropin levels. These findings raise the question of differential tissue sensitivity to androgens. Because ancillary laboratory testing does not predict reliably the genital response, a therapeutic trial should be advocated in such cases.
Keely
E J
EJ
University of Manitoba, Health Sciences Centre, Winnipeg, Canada.
Belsham
D D
DD
Wrogemann
K
K
Faiman
C
C
D000328:Adult; D000728:Androgens / Q000494:pharmacology*; D001667:Binding, Competitive; D004351:Drug Resistance; D005347:Fibroblasts / Q000378:metabolism; D005837:Genitalia, Male / Q000378:metabolism / Q000473:pathology; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D008297:Male; D010413:Penis / Q000002:abnormalities; D011944:Receptors, Androgen / Q000378:metabolism; D012016:Reference Values; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D012867:Skin / Q000378:metabolism / Q000473:pathology
D000728:Androgens; D006062:Gonadotropins; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin