title: Selective loss and selective sparing of neurons in the thalamic reticular nucleus following human cardiac arrest.
abstract: Neurons in the portion of the human thalamic reticular nucleus (RT) associated with the prefrontal cortex and mediodorsal thalamic nuclei were found to be selectively vulnerable to ischemic neuronal damage following relatively short (< or = 5-min) duration cardiac arrest. In contrast, selective sparing of these RT neurons occurred in cases with longer (> 10-min) duration of arrest that was sufficient to produce extensive ischemic neuronal damage throughout the cerebral cortex and thalamic relay nuclei. The selective degeneration of RT neurons appears to require the sustained activity of corticothalamic or thalamocortical projections to the RT following the ischemic insult. Loss of RT neurons associated with the frontal cortex and mediodorsal thalamus may be the biological basis of some types of persisting cognitive deficits in attentional processing experienced by patients following cardiac arrest, open heart surgery, or other forms of brief global cerebral ischemia.
authors.affiliation: Head Injury Center, University of Pennsylvania, Philadelphia 19104.
authors.forename: D T
authors.initials: DT
authors.lastname: Ross
authors.forename: D I
authors.initials: DI
authors.lastname: Graham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002452:Cell Count; D002470:Cell Survival; D002648:Child; D002675:Child, Preschool; D006323:Heart Arrest / Q000473:pathology*; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D013787:Thalamic Nuclei / Q000473:pathology*