[Inhaled nonasbestos fibers; pulmonary concentrations and fiber size in autopsied urban residents].
Nonasbestos fiber concentrations and fiber size distribution in autopsied lung tissues of 53 urban residents (34 males and 19 females) were analyzed by low temperature ashing-analytical transmission electron microscopy. The following findings were obtained. 1. Pulmonary nonasbestos fibers were found in all samples. Fiber consisting mainly of aluminum and silicon represented 80.0% of the total nonasbestos fibers observed. 2. The geometric mean concentration of nonasbestos fiber was significantly higher in males (47.6 x 10(6) fibers/g dry lung) than in females (18.2 x 10(6) fibers/g dry lung) (p < 0.05). This may be caused by differences in occupational exposure to nonasbestos fibers between males and females. 3. In females, the geometric mean concentration of nonasbestos fibers of smokers (34.6 x 10(6) fibers/g dry lung) was higher than that of nonsmokers (11.4 x 10(6) fibers/g dry lung), while, in males, the geometric mean concentration of nonasbestos fibers was lower in smokers (53.9 x 10(6) fibers/g dry lung) than in nonsmokers (89.1 x 10(6) fibers/g dry lung). These differences were not statistically significant. 4. The mean value for the ratio of nonasbestos fiber to asbestos concentration which ranged from 2.3 to 268 in males, and from 1.3 to 52.0 in females, was 30.1 and 20.2 respectively. 5. The mean length, diameter and aspect ratio for nonasbestos fibers were 1.01 microns, 0.103 microns and 11.3, respectively. Although nonasbestos fibers were almost equal in length to asbestos, the mean diameter of nonasbestos fibers was almost one-half of that of asbestos. Most of nonasbestos fibers (99.0%) were too small to be visible by light microscopy.
Sakai
K
K
Nagoya City Public Health Research Institute.
Kojima
A
A
Hisanaga
N
N
Shibata
E
E
Ono
Y
Y
Takeuchi
Y
Y
Aoki
T
T
Takagi
H
H
Ando
T
T
Huang
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000535:Aluminum / Q000032:analysis*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007564:Japan; D008168:Lung / Q000737:chemistry* / Q000473:pathology; D008297:Male; D017348:Microscopy, Electron, Scanning Transmission; D008875:Middle Aged; D016273:Occupational Exposure; D012737:Sex Factors; D012825:Silicon / Q000032:analysis*; D012907:Smoking; D014505:Urban Population
D000535:Aluminum; D012825:Silicon