title: Effect of triacylglycerols on erythrocyte deformability in vitro.
abstract: With Reid's filtration technique as a bioassay for evaluating red blood cell (RBC) deformability, we found that tripalmitolein, triolein and trilinolein improved the deformability of calcium-loaded RBC while glycerol, linoleic acid, dilinoleoyl phosphatidyl choline, trilpalmitin, tristearin, trilinolenin and triarachidonin did not. Maximal effect of tripalmitolein, triolein and trilinolein was achieved at 10(-9), 10(-10) and 10(-8) M respectively. We propose that only those triacylglycerols which contain fatty acids with one or two double bonds could modify RBC membrane fluidity and improve RBC deformability.
authors.affiliation: Department of Medicine, Veterans General Hospital, Taipei, Taiwan, ROC.
authors.forename: C Y
authors.initials: CY
authors.lastname: Hong
authors.forename: L J
authors.initials: LJ
authors.lastname: Lai
authors.forename: M S
authors.initials: MS
authors.lastname: Shiao
authors.forename: B N
authors.initials: BN
authors.lastname: Chiang
mesh_terms: D004305:Dose-Response Relationship, Drug; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006801:Humans; D014280:Triglycerides / Q000494:pharmacology*
chemical_list: D014280:Triglycerides