title: Structure and function of the bacteriophage T7 RNA polymerase (or, the virtues of simplicity).
abstract: A consideration of the properties of a number of mutants of T7 RNA polymerase, together with emerging structural information (Sousa et al., 1993) allows an interpretation of the the mechanics of transcription by this relatively simple RNA polymerase. Evidence indicating features in common with other nucleotide polymerases (such as DNA polymerases and reverse transcriptases) is reviewed.
authors.affiliation: Department of Microbiology and Immunology, Morse Institute of Molecular Genetics, SUNY Health Science Center, Brooklyn 11203-2098.
authors.forename: W T
authors.initials: WT
authors.lastname: McAllister
mesh_terms: D017123:Bacteriophage T7 / Q000235:genetics; D001483:Base Sequence; D004279:DNA, Viral / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011485:Protein Binding; D014158:Transcription, Genetic; D014764:Viral Proteins
chemical_list: D004279:DNA, Viral; D004268:DNA-Binding Proteins; D014764:Viral Proteins; C062210:bacteriophage T7 RNA polymerase; D012321:DNA-Directed RNA Polymerases