title: Evaluation of cold air challenge data in a population sample using a model of bronchial hyperreactivity and disposition to bronchial obstruction.
abstract: To explore the role of bronchial hyperreactivity and obstruction after cold air challenge, data from a cross-sectional study of more than 7,000 10-year-old children were used. Current knowledge of hyperreactivity is primarily based on pharmacological provocation tests with variable prechallenge flow rates and their decrease relative to baseline. Using forced expiratory volume (FEV) in 1 sec values before and after cold air challenge, however, it is possible to define a subsample of children with predominant hyperreactivity and a subsample with predominant obstruction after challenge. The prevalence of respiratory symptoms and the diagnoses in the two subsamples were compared. The analysis showed that children with bronchial obstruction have nearly the same frequency of respiratory symptoms as those with bronchial hyperreactivity. A combined model of bronchial obstruction and hyperreactivity was, therefore, more predictive of symptoms than a model of hyperreactivity alone.
authors.affiliation: GSF-Forschungszentrum fuer Umwelt und Gesundheit, Institut fuer Epidemiologie, Neuherberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Wjst
authors.forename: S
authors.initials: S
authors.lastname: Dold
authors.forename: P
authors.initials: P
authors.lastname: Reitmeir
authors.forename: A
authors.initials: A
authors.lastname: Wulff
authors.forename: T
authors.initials: T
authors.lastname: Nicolai
authors.forename: E
authors.initials: E
authors.lastname: von Mutius
mesh_terms: D000388:Air; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000503:physiopathology*; D002648:Child; D003080:Cold Temperature; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008954:Models, Biological; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity