title: Histologic investigation of the biologic behavior of different hydroxyapatite plasma-sprayed coatings in rabbits.
abstract: The aim of this study was to investigate bone response to and biostability of three different hydroxyapatite (HA)-coatings. Therefore, coated and uncoated titanium implants were inserted into the tibia of rabbits. Implantation times were at 3 and 12 weeks. The histological evaluation included measurement of the amount of bone apposition to the various implant surfaces. The results demonstrated at 3 and 12 weeks no marked differences in bony reaction at the cortical level to the different implant materials. However, compared with the 3-week specimens, at 12 weeks extensive maturation of the woven bone callus had occurred. In addition, all 12-week implants induced bone formation in the medullary cavity. It was also noted that all HA-coatings showed loss of coating thickness. Quantitative determination of bone contact demonstrated that all 12-week implants showed the same high amount of bone apposition.
authors.affiliation: Department of Oral Function and Prosthetic Dentistry, Dental School, University of Nijmegen, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
authors.forename: J P
authors.initials: JP
authors.lastname: van der Waerden
authors.forename: J G
authors.initials: JG
authors.lastname: Wolke
mesh_terms: D000818:Animals; D001846:Bone Development; D002516:Ceramics / Q000633:toxicity*; D005260:Female; D006882:Hydroxyapatites / Q000633:toxicity*; D008863:Microspheres; D010316:Particle Size; D019736:Prostheses and Implants; D011817:Rabbits; D014025:Titanium; D014961:X-Ray Diffraction
chemical_list: D006882:Hydroxyapatites; D014025:Titanium