[Repairing mechanisms of lupus nephritis in NZB/NZW mice by bone marrow transplantation].
We have recently found that allogenic bone marrow transplantation (BMT) can be used to treat lupus nephritis in NZB x NZW F1 (B/W F1) and BXSB mice. To elucidate why and how glomerular damage is repaired, serial renal biopsies were carried out using B/W F1 mice before, and after BMT. Donor-derived B cells and macrophages with normal functions developed two weeks after BMT, whereas donor-derived functional T cells were generated after seven weeks of BMT. Visceral epithelial cells as well as macrophages in the glomeruli were activated (probably by T cell-derived lymphokines) at this time; they showed marked phagocytic activity, resulting in clearance of immune complexes (ICs) and repair of damaged basement membranes. These results suggest that normal T cell functions, which have the capacity to activate macrophages and epithelial cells, are essential in repairing IC-mediated glomerular damage.
Nishioka
N
N
Department of Internal Medicine, Osaka Red Cross Hospital, Japan.
Ikehara
S
S
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism; D016026:Bone Marrow Transplantation; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D007668:Kidney / Q000276:immunology / Q000378:metabolism; D008181:Lupus Nephritis / Q000601:surgery*; D051379:Mice; D008814:Mice, Inbred NZB; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D000936:Antigen-Antibody Complex; D016207:Cytokines