[The inhibiting effect of ortofen and indomethacin in relation to the development of induced nervous system tumors in rats].
The anticarcinogenic effects of the nonsteroidal antiinflammatory drugs ortophen and indomethacin on carcinogenesis of the nervous and renal systems were studied. Glial tumors of the brain and spinal cord, neurinomas of peripheral nerves and renal mesenchymal tumors were induced in rats through a single transplacental administration of N-ethyl-N-nitrosourea, 75 mg/kg body weight. Ortophen and indomethacin each used in a dose of 20 mg/litre of drinking water in the period of postnatal life were effective in inhibiting the growth of brain and spinal cord tumors, showed a statistically insignificant tendency to suppress the growth of peripheral nervous tumors, but failed to affect the growth of renal tumors.
Bespalov
V G
VG
Aleksandrov
V A
VA
Petrov
A S
AS
Lidak
M Iu
MIu
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D005038:Ethylnitrosourea; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D004008:Diclofenac; D005038:Ethylnitrosourea; D007213:Indomethacin
Tormoziashchiĭ éffekt ortofena i indometatsina v otnoshenii razvitiia indutsirovannykh opukholeĭ nervnoĭ sistemy u krys.