Interaction of motor neurone disease plasma with glucose transport.
Abnormal glucose metabolism has been implicated in motor neurone disease (MND) and this was studied by measuring the transport of non-metabolisable glucose analogue, 3-O-methyl-D-glucose in normal erythrocyte at 20 degrees C, pH 7.4, in the presence of plasma from normal controls and patients with MND. The glucose uptake was elevated by 34% in the presence of plasma from MND patients (n = 21) when compared with age matched controls (n = 28; p < 0.001). The uptake of glucose was not influenced by gender or any age dependent variations. The relationship of this effect to glucose under-utilisation in the CNS needs to be explored.
Karim
A R
AR
Department of Neuropathology, Midland Centre for Neurosurgery and Neurology, Smethwick, Warley, United Kingdom.
Virk
P K
PK
Rossi
M L
ML
Williams
A C
AC
Sturman
S G
SG
D000328:Adult; D000368:Aged; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008757:Methylglucosides / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D010949:Plasma / Q000378:metabolism
D008757:Methylglucosides; D005947:Glucose