Octreotide changes serum thyrotropin (TSH) glycoisomer distribution as assessed by lectin chromatography in a TSH macroadenoma patient.
A 28-yr-old woman with hyperthyroidism due to a TSH/GH-secreting macroadenoma was treated preoperatively with octreotide to attain euthyroidal status. Lectin chromatography, performed on her immunopurified serum TSH obtained at baseline and 1 week after 50 micrograms three times daily octreotide therapy, revealed a significant increase in ricin binding after octreotide. This result is consistent with increased amounts of TSH isoforms with more exposed galactose residues. Further clinical studies to elucidate the effects of pharmacological agents on serum TSH isoforms and TSH bioactivity are needed.
Francis
T B
TB
Endocrine-Metabolic Service, Walter Reed Army Institute of Research, Washington D.C. 20307.
Smallridge
R C
RC
Kane
J
J
Magner
J A
JA
D000236:Adenoma / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D000328:Adult; D002845:Chromatography; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology; D015282:Octreotide / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000601:surgery; D012276:Ricin / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D013972:Thyrotropin / Q000097:blood* / Q000378:metabolism
D013972:Thyrotropin; D012276:Ricin; D015282:Octreotide