Protein kinase C: mediator or inhibitor of insulin action?
The role of protein kinase C in insulin signal transduction is controversial. It has been postulated that protein kinase C is activated by insulin and that the kinase is directly involved in insulin-mediated metabolic processes. In opposition to this view is the hypothesis that protein kinase C is not activated by insulin and, more importantly, may be responsible for attenuation of the insulin signal. The evidence for and against protein kinase C as a mediator of the insulin signal will be put in perspective followed by discussion of the possible role of the kinase in the pathogenesis of insulin resistance in type II diabetes.
Considine
R V
RV
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Caro
J F
JF
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology; D005544:Forecasting; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007329:Insulin Antagonists; D011493:Protein Kinase C / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D007328:Insulin; D007329:Insulin Antagonists; D011493:Protein Kinase C