Stereochemistry and dynamics of the inclusion complex of (S)-(+)-fenoprofen with cyclomaltoheptaose (beta-cyclodextrin).
The inclusion complex of the calcium salt of (S)-2-(3-phenoxyphenyl)propionic acid with cyclomaltoheptaose (beta-cyclodextrin) was investigated by 1H NMR spectroscopy. The stoichiometry of the complex was determined by the continuous variation method and the association constant by the Benesi-Hildebrand procedure. Measurements of proton selective relaxation rates allowed the dynamics of the complex to be investigated and the determination of intermolecular 1H(1H)-NOE enhancements revealed the stereochemistry in solution.
Uccello-Barretta
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G
Centro di Studio del CNR per le Macromolecole Stereordinate ed Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Pisa, Italy.
Chiavacci
C
C
Bertucci
C
C
Salvadori
P
P
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D003505:Cyclodextrins / Q000737:chemistry*; D005279:Fenoprofen; D006859:Hydrogen; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D008969:Molecular Sequence Data; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D006859:Hydrogen; C031215:betadex; D005279:Fenoprofen