title: The effect of lidocaine on growth of cells of head and neck squamous cell carcinoma.
abstract: The effect of lidocaine on the growth rate of human squamous cell carcinoma of the head and neck area was investigated in tissue culture. As growth parameters, the mean cell area, the total cell area, the field area and the total number of cells have been measured by digital image analysis. The carcinoma's two cell types--round and spindle--were recorded separately to verify different patterns of alteration. All parameters did not decrease significantly when lidocaine was given as a single dose prior to the culture. A significant decrease (p < 0.05) at day 6, 9 and 12 in culture was found when lidocaine (7 micrograms ml-1) was added to the culture medium.
authors.affiliation: Department of Maxillofacial Surgery, Georg-August-University of Gottingen, Germany.
authors.forename: K G
authors.initials: KG
authors.lastname: Wiese
authors.forename: M
authors.initials: M
authors.lastname: Korabiowska
authors.forename: J
authors.initials: J
authors.lastname: Tyrak
authors.forename: S
authors.initials: S
authors.lastname: Bartkowski
authors.forename: J
authors.initials: J
authors.lastname: Stypukowska
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000503:physiopathology; D002455:Cell Division / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D003470:Culture Media; D005153:Facial Neoplasms / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007267:Injections; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D009062:Mouth Neoplasms / Q000473:pathology / Q000503:physiopathology; D012878:Skin Neoplasms / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D003470:Culture Media; D008012:Lidocaine