title: Multivariate assessment of computer-analyzed corneal topographers.
abstract: Methodological aspects of multivariate statistical models to describe and to assess data from computer-analyzed corneal topographers (CACT) are considered. The data generated by repeated curvature mappings of calibrated steel balls are discussed in detail with the objective of formulating the basic questions and suggesting directions to assess data from clinical applications of CACT. The interpretation of seemingly straightforward concepts such as accuracy and precision is revisited with the objective of understanding its meaning in future clinical and experimental applications of CACT. Some of the statistical problems related to the analysis of corneal astigmatism based on CACT data are also discussed.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago 60612.
authors.forename: M A
authors.initials: MA
authors.lastname: Viana
authors.forename: I
authors.initials: I
authors.lastname: Olkin
authors.forename: T T
authors.initials: TT
authors.lastname: McMahon
mesh_terms: D001251:Astigmatism / Q000473:pathology; D003315:Cornea / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008433:Mathematics; D015233:Models, Statistical; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D015203:Reproducibility of Results