title: Pharmacokinetics of ibuprofen in lactating dairy cows.
abstract: The pharmacokinetics of ibuprofen were studied in 6 adult lactating dairy cows after a single IV or oral administration of ibuprofen (25 mg/kg of body weight). Ibuprofen concentrations in milk and serum were analyzed by use of high-performance liquid chromatography. The lower limit of detection of the ibuprofen assay was 50 ng/ml. Serum ibuprofen concentration-time curves after IV administration best fit an open two-compartment model. Harmonic mean volume of distribution at steady state was 0.14 (range, 0.12 to 0.17) L/kg, elimination half-life was 1.55 (range, 1.33 to 1.73) hours, and total clearance was 86.2 (range, 68.8 to 106.2) ml/kg/h. Harmonic mean oral bioavailability was 99% (range, 79 to 112). Adverse effects were not observed in cows given ibuprofen.
authors.affiliation: Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849.
authors.forename: F J
authors.initials: FJ
authors.lastname: DeGraves
authors.forename: K L
authors.initials: KL
authors.lastname: Anderson
authors.forename: D P
authors.initials: DP
authors.lastname: Aucoin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D007052:Ibuprofen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D007774:Lactation / Q000378:metabolism*; D008657:Metabolic Clearance Rate
chemical_list: D007052:Ibuprofen