title: Influence of angiotensin converting enzyme inhibition on exercise performance and clinical symptoms in chronic heart failure: a multicentre, double-blind, placebo-controlled trial.
abstract: One hundred and seven patients with chronic heart failure (NYHA class II to IV) stabilized on digitalis and/or diuretics, recruited from 11 centres were randomized into a double-blind, placebo-controlled study to assess the effect of 12 weeks of cilazapril therapy on exercise tolerance and clinical status. Thirty-five patients were randomized to placebo and 72 to cilazapril at a starting dose of 1 mg daily; titration to cilazapril 2.5 mg at week 4 and 5 mg at week 8 (or matching placebo) was carried out in patients who did not improve clinically. Demographic characteristics, including exercise test duration increased from 402 s (+/- 17 SEM) at baseline to 462 s (+/- 19 SEM) at week 12 for the cilazapril group (+15%) and from 405 s (+/- 23 SEM) at baseline to 408 s (+/- 30 SEM) at week 12 in patients on placebo (+1%) (P < 0.001). In the placebo group, patients able to exercise for more than 6 min at baseline showed an increase in exercise duration at week 12 while those able to exercise for up to 6 min at baseline showed a decrease (P = ns). In contrast, cilazapril-treated patients showed an increase in exercise tolerance regardless of baseline exercise test duration; patients with the most impaired exercise tolerance at baseline showed a greater improvement than patients with mildly impaired baseline exercise tolerance (P < 0.05 vs placebo). NYHA class improved by at least one grade in 51% of the cilazapril group vs 32% in the placebo group (P = ns). At the end of the trial, 15% of the patients were non-responders on cilazapril vs 41% on placebo (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Cardiovascular Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Dössegger
authors.forename: E
authors.initials: E
authors.lastname: Aldor
authors.forename: M G
authors.initials: MG
authors.lastname: Baird
authors.forename: S
authors.initials: S
authors.lastname: Braun
authors.forename: J G
authors.initials: JG
authors.lastname: Cleland
authors.forename: R
authors.initials: R
authors.lastname: Donaldson
authors.forename: L J
authors.initials: LJ
authors.lastname: Jansen
authors.forename: M D
authors.initials: MD
authors.lastname: Joy
authors.forename: J A
authors.initials: JA
authors.lastname: Marin-Neto
authors.forename: E
authors.initials: E
authors.lastname: Nogueira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000503:physiopathology; D017315:Cilazapril / Q000627:therapeutic use*; D004311:Double-Blind Method; D005080:Exercise Test; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D017315:Cilazapril