title: Non-traumatic rhabdomyolysis complicating antihistamine overdose.
abstract: Antihistamines are common over the counter medications which are frequently involved in overdoses. The usual clinical course is dominated by the anticholinergic affects of these agents; it includes significant autonomic and central nervous system effects and direct cardiac toxicity (1). We report a case of a suicide attempt in a young adult male where ingestion of the antihistamines diphenhydramine and doxylamine was complicated by non-traumatic rhabdomyolysis and acute renal failure.
authors.affiliation: Renal Division, Erie County Medical Center, Buffalo, NY 14215.
authors.forename: D
authors.initials: D
authors.lastname: Frankel
authors.forename: J
authors.initials: J
authors.lastname: Dolgin
authors.forename: B M
authors.initials: BM
authors.lastname: Murray
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D000328:Adult; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004155:Diphenhydramine / Q000506:poisoning*; D004319:Doxylamine / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D013406:Suicide, Attempted
chemical_list: D004155:Diphenhydramine; D004319:Doxylamine; D003404:Creatinine