title: Human T-lymphotropic virus type I seroprevalence among Japanese Americans.
abstract: The epidemiology of human T-lymphotropic virus type I (HTLV-I) infection is not well defined in Japanese Americans. This impairs using approaches that could reduce viral transmission and monitor carriers for the disease. Using enzyme-linked immunosorbent assay and p21e recombinant Western blot testing, HTLV-I antibody was measured in unlinked samples from Japanese-American patients at 4 physicians' offices in San Francisco, California. Of 442 patients, 4 (0.9%; 95% confidence interval 0.25%, 2.3%) were confirmed seropositive, all with an HTLV-I rather than an HTLV-II pattern on Western blot. Seroprevalence was highest among the issei or immigrant generation (3/230 or 1.3%) compared with the second-generation nisei (1/191 or 0.5%) or third-generation sansei (0 of 17). Prevalence did not differ by age or sex, although the number of positive subjects in each subgroup was small. Of 88 patients with familial origins in endemic areas of southern Japan, none were seropositive. In this sample of Japanese Americans, HTLV-I seroprevalence was lower than in residents of endemic southern Japan but higher than among American blood donors. The prevalence was most similar to that in nonendemic areas of Japan. The public health implications of HTLV-I infection among Japanese Americans are discussed.
authors.affiliation: Department of Laboratory Medicine, University of California, San Francisco 94143-0884.
authors.forename: E L
authors.initials: EL
authors.lastname: Murphy
authors.forename: K F
authors.initials: KF
authors.lastname: Varney
authors.forename: N T
authors.initials: NT
authors.lastname: Miyasaki
authors.forename: R J
authors.initials: RJ
authors.lastname: Moore
authors.forename: J I
authors.initials: JI
authors.lastname: Umekubo
authors.forename: A N
authors.initials: AN
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Khayam-Bashi
mesh_terms: D000328:Adult; D000368:Aged; D001213:Asian; D016001:Confidence Intervals; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000208:ethnology*; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies; D014481:United States / Q000453:epidemiology
chemical_list: D015481:HTLV-I Antibodies