title: Endothelial function in congestive heart failure.
abstract: There is evidence that the endothelium plays an important role in the control of human vascular tone by releasing endothelium-derived nitric oxide and, therefore, a defective endothelial function could be involved in the increased peripheral vasoconstriction of patients with chronic congestive heart failure. To investigate endothelial function in humans in vivo, agents such as acetylcholine, a short-acting stimulator of the release of endothelium-derived nitric oxide, has been used. Conversely, N-mono-methyl-L-arginine, a specific inhibitor of nitric oxide synthesis from L-arginine, has recently been shown to decrease blood flow during infusion into the brachial artery of healthy volunteers (control subjects) by inhibiting the basal release of nitric oxide. Consistent with experimental studies, the blood flow response to acetylcholine is blunted in patients with chronic heart failure compared with healthy age-matched volunteers. In contrast, the decrease in blood flow induced by N-mono-methyl-L-arginine appears to be exaggerated in congestive heart failure. The blood flow response to nitroglycerin or sodium nitroprusside, endothelium-independent vasodilators, is usually preserved in patients with chronic, nonedematous heart failure, indicating a normal response of the vascular smooth muscle of resistance vessels to exogenous nitric oxide. In contrast, the dilator response of the radial artery diameter to nitroglycerin and flow-dependent dilation is impaired in patients with chronic heart failure, indicating that the abnormal flow-mediated relaxation of large arteries may be caused by both endothelial and structural abnormalities.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Medizinische Klinik III, University of Freiburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Drexler
authors.forename: D
authors.initials: D
authors.lastname: Hayoz
authors.forename: T
authors.initials: T
authors.lastname: Münzel
authors.forename: H
authors.initials: H
authors.lastname: Just
authors.forename: R
authors.initials: R
authors.lastname: Zelis
authors.forename: H R
authors.initials: HR
authors.lastname: Brunner
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D014661:Vasoconstriction / Q000502:physiology
chemical_list: D009569:Nitric Oxide