title: N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides with antiinflammatory, analgesic, antipyretic and platelet antiaggregating activities.
abstract: The synthesis of a series of N-substituted 4-carboxy-1-phenyl-1H-pyrazole-5-propanamides by reaction of 1-phenyl-1H-oxepino[4,3-c]pyrazole-4(8H),6(7H)-dione with aromatic primary amines is described. Some amides showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as moderate antiinflammatory, analgesic and antipyretic activities in rats or mice.
authors.affiliation: Istituto di Scienze Farmaceutiche dell'Università Viale Benedetto XV, Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Menozzi
authors.forename: L
authors.initials: L
authors.lastname: Mosti
authors.forename: P
authors.initials: P
authors.lastname: Schenone
authors.forename: M
authors.initials: M
authors.lastname: D'Amico
authors.forename: C
authors.initials: C
authors.lastname: Falzarano
authors.forename: F
authors.initials: F
authors.lastname: Rossi
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010975:Platelet Aggregation Inhibitors; D011720:Pyrazoles