J5 prevents endotoxin shock in suckling rats.
A sublethal dose of endotoxin (lipopolysaccharide: LPS) can induce endotoxin tolerance. It is not well known whether LPS feeding causes endotoxemia and endotoxin tolerance in the newborn. Since Rc mutant Escherichia coli LPS (J5) does not have toxic or lethal effects, J5 is used to induce endotoxin tolerance in this study. This study showed that both an intraperitoneal (ip) injection and feeding of Rc mutant Escherichia coli LPS (J5) induced endotoxin tolerance in suckling rats.
Yoshioka
T
T
Department of Pediatrics, Loyola University of Chicago, Maywood, IL 60153.
Goto
M
M
Kodama
M
M
Gottschalk
M E
ME
Anderson
C L
CL
Young
M R
MR
Zeller
W P
WP
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D004731:Endotoxins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004926:Escherichia coli; D007108:Immune Tolerance; D007274:Injections, Intraperitoneal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000517:prevention & control*
D004731:Endotoxins