title: Subchronic toxicity study of methyl hesperidin in mice.
abstract: A subchronic toxicity study of methyl hesperidin was performed using B6C3F1 mice. The flavonoid was administered to groups of ten males and ten females in dietary levels of 0, 0.3, 0.6, 1.25, 2.5 and 5.0% for 13 weeks. No significant treatment-related differences were found in data for body weights, food and water consumption, hematology, clinical chemistry and organ weights. Furthermore, no effects of treatment were observed on gross and histopathological examination of the major organs. The present experiment thus demonstrated that methyl hesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet.
authors.affiliation: First Department of Pathology, Nagoya City University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kawabe
authors.forename: S
authors.initials: S
authors.lastname: Tamano
authors.forename: M A
authors.initials: MA
authors.lastname: Shibata
authors.forename: M
authors.initials: M
authors.lastname: Hirose
authors.forename: S
authors.initials: S
authors.lastname: Fukushima
authors.forename: N
authors.initials: N
authors.lastname: Ito
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006569:Hesperidin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects
chemical_list: D006569:Hesperidin; C052037:methyl hesperidin