Priming stimulation facilitates Hebb-type plasticity in the Schaffer collateral-commissural pathways of the mouse hippocampus.
Hebb-type plastic changes of synaptic transmission were analyzed in the Schäffer collateral-commissural pathways (SC) of the mouse hippocampal slice. Low frequency (0.05-0.1 Hz) SC stimulation (S2) was paired with intracellular depolarization (100-200 ms; 2-3 nA) of CA1 pyramidal. Postpairing facilitation of synaptic responses in picrotoxin-free medium occurred only when S2 was "primed" with neurons the preceding shock (S1) administered through the same electrode 200 ms before S2. Priming-determined disinhibition in local circuitry is supposed to be responsible for this phenomenon.
Fedorov
N B
NB
Institute of Brain Research, Russian Academy of Medical Science, Moscow.
Sergeeva
O A
OA
Skrebitsky
V G
VG
D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology / Q000379:methods; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D010566:Virulence Factors, Bordetella