Bacterial adherence and epithelial cell cytokine production.
Epithelial cell lines produce the cytokines IL-1 alpha, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.
Svanborg
C
C
Dept. of Medical Microbiology, University of Lund, Sweden.
Agace
W
W
Hedges
S
S
Linder
H
H
Svensson
M
M
D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis*; D004848:Epithelium / Q000276:immunology / Q000382:microbiology; D004926:Escherichia coli / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology / Q000382:microbiology; D014551:Urinary Tract / Q000276:immunology / Q000382:microbiology
D016207:Cytokines