title: [A giant esophageal ulcer in a hemophiliac with HIV infection].
abstract: A 21-year-old man with hemophilia B and human immunodeficiency virus (HIV) infection was admitted with hematemesis and melena. After admission, esophagogram and endoscopy showed a single giant ulcer with ovoid shape and slightly irregular margins in the middle esophagus. Biopsy specimens of the esophageal ulcer showed non-specific granulation and etiology was unknown. Therapeutic trails of famotidine, sodium alginate, acyclovir, and amphotericin B did not result in favorable response. With a combination therapy of dexamethasone and sucralfate, the swallowing pain was rapidly disappeared with gradual improvement of the ulcer. To our knowledge, this is the first report of a giant esophageal ulcer in a HIV infected patient in Japan.
authors.affiliation: Department of Pediatrics, Saga Prefectural Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Muraoka
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Kajiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Simoda
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004935:Esophageal Diseases / Q000188:drug therapy / Q000209:etiology*; D015658:HIV Infections / Q000150:complications*; D002836:Hemophilia B / Q000209:etiology*; D006801:Humans; D008297:Male; D013392:Sucralfate / Q000008:administration & dosage; D014456:Ulcer / Q000188:drug therapy / Q000209:etiology
chemical_list: D013392:Sucralfate; D003907:Dexamethasone