Antiviral activity of a synthetic double-stranded polyribonucleotide interferon inducer in a murine AIDS retrovirus model. Role of augmentation of natural killer cell activity and synergy with oral AZT.
Black
P L
PL
Division of Antiviral Drug Products, Food and Drug Administration, Rockville, Maryland 20857.
McKinnon
K M
KM
Wooden
S L
SL
Ussery
M A
MA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology* / Q000031:analogs & derivatives; D004357:Drug Synergism; D007155:Immunologic Factors / Q000494:pharmacology*; D007369:Interferon Inducers / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D016183:Murine Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D011070:Poly I-C / Q000494:pharmacology*; D011107:Polylysine / Q000494:pharmacology* / Q000031:analogs & derivatives; D011925:Rauscher Virus / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D007155:Immunologic Factors; D007369:Interferon Inducers; D011107:Polylysine; D015215:Zidovudine; C019531:poly ICLC; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C