Biphasic increase of calcitonin gene-related peptide-like immunoreactivity in rat hypoglossal motoneurons after nerve transection.
In the hypoglossal system the regulation of calcitonin gene-related peptide (CGRP) following peripheral nerve transection and prevention of reinnervation was studied using immunocytochemistry. In the adult rat axotomy resulted in a biphasic increase of CGRP-immunoreactivity (IR) with a first peak after 2 days and a second peak after 18 days. In addition to an increase in staining intensity the number of CGRP-IR motoneurons was also increased. The lesion-induced alterations of CGRP-expression in the hypoglossal nucleus correspond to those described in other motor system. A possible contribution of CGRP to degeneration/regeneration processes is discussed.
Grothe
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Department of Anatomy and Cell Biology, University of Marburg, Germany.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D003714:Denervation; D007002:Hypoglossal Nerve / Q000378:metabolism* / Q000601:surgery; D007150:Immunohistochemistry; D009046:Motor Neurons / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation
D015740:Calcitonin Gene-Related Peptide