title: Design and discovery of new drugs by stepping-up and stepping-down approaches.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033.
authors.forename: E J
authors.initials: EJ
authors.lastname: Lien
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D013329:Structure-Activity Relationship