title: Effect of phenobarbitone on pituitary gland of male albino mice.
abstract: The effects of phenobarbitone on gonadotrophs and lactotrophs of pituitary gland were studied in male albino mice which were administered phenobarbitone 50 mg/kg body weight intraperitoneally (ip) daily for 14 days. A group of control mice were administered saline ip. In the experimental group, there was significant reduction in the average cell population of FSH cells in the cephalomedian area (P < 0.001) and in the lateral lobe (P < 0.01). The average volume of both FSH and LH cells was also significantly reduced (P < 0.001). The changes in the gonadotrophs of the experimental group could be attributed to the negative feedback action of testosterone which is being secreted from hypertrophied Leydig cells of testis.
authors.affiliation: Department of Anatomy, Kasturba Medical College, Mangalore.
authors.forename: D
authors.initials: D
authors.lastname: Chakraborty
authors.forename: S
authors.initials: S
authors.lastname: Karanth
mesh_terms: D000818:Animals; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D010634:Phenobarbital