title: Follow up study of workers exposed to man made mineral fibres.
abstract: A survey of workers in seven man made mineral fibre (MMMF) production plants, the subject of a previous report, was conducted, with other blue collar workers serving as regional comparisons. Based on the median reading of chest radiographs by five readers, a low prevalence of small opacities, all at the 1/0 and 1/1 profusion levels, was again found: for workers with MMMFs, 23/1435 (1.6%); for comparison workers, 2/305 (0.7%). Spirometric measurements indicated generally healthy populations, and were not related to presence of opacities. Ninety three per cent (21/23) of MMMF workers with opacities worked at the two plants with the highest exposures to fine fibres, resulting in a dose-response relation across plants. For one location, the prevalences of opacities for the MMMF and comparison workers were not significantly different (5.9% (13/220) v 3.1% (2/65)). No comparison x ray films were obtained for the MMMF plant with the highest prevalence (6.6%), so a second phase of the study was conducted, with pre-employment films from these two plants. On this second reading, the prevalence of opacities was lower; there were no significant differences between the two groups of films, and no relation between opacities and exposure indices. There was considerable inter and intrareader variability. These results indicate no adverse clinical, functional or radiographic signs of effects of exposure to MMMFs in these workers.
authors.affiliation: Tulane University School of Medicine, Department of Medicine, New Orleans, Louisiana 70112.
authors.forename: J M
authors.initials: JM
authors.lastname: Hughes
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: H W
authors.initials: HW
authors.lastname: Glindmeyer
authors.forename: Y Y
authors.initials: YY
authors.lastname: Hammad
authors.forename: H
authors.initials: H
authors.lastname: Weill
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D015995:Prevalence; D011859:Radiography; D012907:Smoking; D013997:Time Factors
chemical_list: D008903:Minerals