title: The development of systemic sclerosis (scleroderma) following augmentation mammoplasty.
abstract: We describe 3 patients developing systemic sclerosis (scleroderma) following breast augmentation with paraffin injections, and saline and silicone gel filled implants. Although previously considered inert, silicone appears capable of inducing human adjuvant disease including scleroderma in the susceptible individual. The occurrence of systemic sclerosis following the use of silicone implants however, appears to be uncommon.
authors.affiliation: University of Toronto Rheumatic Disease Unit, Wellesley Hospital, ON, Canada.
authors.forename: B E
authors.initials: BE
authors.lastname: Appleton
authors.forename: P
authors.initials: P
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects*; D008875:Middle Aged; D010232:Paraffin; D019736:Prostheses and Implants / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000209:etiology*; D012828:Silicones; D012965:Sodium Chloride
chemical_list: D012828:Silicones; D012965:Sodium Chloride; D010232:Paraffin