Expansion of gut associated immunoglobulin A secreting lymphocytes in rheumatoid arthritis correlates with high levels of serum IgA.
We report the emergence of polyclonal expansion of gut lymphocyte associated tissues producing IgA in a patient with rheumatoid arthritis associated with a high serum IgA concentration. The role of IgA in rheumatoid arthritis is reviewed.
Jorgensen
C
C
Department of Immuno-Rheumatology, Centre Gui-de-Chauliac, Montpellier, France.
Anaya
J M
JM
Barneon
G
G
Sany
J
J
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology*; D008214:Lymphocytes / Q000378:metabolism*; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
D007070:Immunoglobulin A; D011241:Prednisone; D008727:Methotrexate