Estimation of reference intervals from a SENIEUR protocol compatible aged population for immunogerontological studies.
Because many laboratory values change with age, the study of healthy aging as well as diagnosis of disease in geriatric patients requires specific age-corrected reference intervals. We have established such reference intervals for a healthy population aged 65-74 years by selection of a sample group applying the clinical criteria of the SENIEUR protocol and we have compared them with those of a young control group (20-33 years) fulfilling the same criteria. Significant or minor elevations were seen, e.g. for plasma concentrations of fasting glucose, urea, total and LDL-cholesterol, triglycerides, gamma-glutamyl-transferase, alkaline phosphatase, erythrocyte sedimentation rate and serum neopterin levels. These reference intervals can be used for selecting a SENIEUR compatible population aged between 65 and 74 years. Additionally, plasma lipid parameters (cholesterol, triglycerides) are proposed to be included in the SENIEUR protocol.
Stulnig
T
T
Institute for General and Experimental Pathology, University of Innsbruck, Austria.
Mair
A
A
Jarosch
E
E
Schober
M
M
Schönitzer
D
D
Wick
G
G
Huber
L A
LA
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood* / Q000276:immunology; D002985:Clinical Protocols; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D012016:Reference Values
D008055:Lipids