title: Effect of the reduction of skin contamination on the internal dose of creosote workers exposed to polycyclic aromatic hydrocarbons.
abstract: Ten creosote-exposed workers of a wood impregnation plant participated in this study, which took place in two consecutive weeks on a Monday, after a weekend off. On one of the two days each worker wore Tyvek coveralls underneath his normal workclothes. Dermal contamination measurements (pyrene on exposure pads) and biological monitoring (urinary 1-OH-pyrene) were performed to measure the reduction of both the skin contamination and the internal dose. The total pyrene skin contamination of workers not wearing coveralls ranged between 47 and 1510 micrograms.d-1 (0.2-7.5 mumol.d-1). On the average, the coveralls reduced the pyrene contamination on the workers' skin by about 35 (SD 63)%. The excreted amount of 1-OH-pyrene in urine decreased significantly from 6.6 to 3.2 micrograms (30.2 to 14.7 nmol). Multiple regression analysis showed that skin contamination by polycyclic aromatic hydrocarbons is the main determinant of the internal exposure dose of creosote workers.
authors.affiliation: Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Van Rooij
authors.forename: E M
authors.initials: EM
authors.lastname: Van Lieshout
authors.forename: M M
authors.initials: MM
authors.lastname: Bodelier-Bade
authors.forename: F J
authors.initials: FJ
authors.lastname: Jongeneelen
mesh_terms: D000328:Adult; D001944:Breath Tests; D003407:Creosote; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000517:prevention & control*; D016273:Occupational Exposure; D011481:Protective Clothing; D011721:Pyrenes / Q000009:adverse effects* / Q000493:pharmacokinetics; D012044:Regression Analysis; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012871:Skin Diseases / Q000139:chemically induced / Q000517:prevention & control*; D013997:Time Factors; D014934:Wood
chemical_list: D011721:Pyrenes; D003407:Creosote; C030984:pyrene