title: [A case of sporadic and transient bradyarrhythmias in a patient with a glioma in the medulla oblongata].
abstract: In a 20-year-old female patient with a brain stem glioma in the medulla oblongata in association with paraplegia and respiratory paralysis, bradyarrhythmias such as sinus bradycardia and sinus arrest repeated sporadically and transiently, but soon subsided as radiotherapy was being delivered to the glioma in the medulla oblongata. The bradyarrhythmias were differentiated from sick sinus syndrome in their sporadic and transient character. The patient responded normally to atropine, isoproterenol, and phenylephrine. Parasympathetic nerve reflexes induced by Aschner's, Czermak's, and Valsalva's maneuvers and sympathetic nerve reflex induced by change of body position were within normal limits. Although EKG abnormalities associated with diseases of the central nervous system are frequently due to intracranial hypertension and/or irritation of the hypothalamus, the bradyarrhythmias in this patient were possibly due to vagus stimulation caused by the glioma in the medulla.
authors.affiliation: Department of Anesthesiology, Chiba Cancer Center Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Kawasaki
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Kon
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D001919:Bradycardia / Q000209:etiology*; D001932:Brain Neoplasms / Q000150:complications*; D005260:Female; D005910:Glioma / Q000150:complications*; D006801:Humans; D008526:Medulla Oblongata