title: Nasal hyperreactivity. A histamine provocation model.
abstract: The aim of the study was to see whether it is possible to select non-allergic persons with hyperreactivity, especially in the nose, from healthy individuals with a histamine standardization test. Another aim was to elucidate whether a so-called priming effect could be present in such a non-allergic disorder. Seven patients with a history of perennial rhinitis, expressed as either or both swelling or discharge from the nose and a negative allergic investigation, were examined on three up to seven consecutive occasions. Rhinostereometry was used to register the reaction in the mucous membrane to a solution of histamine in successively increased concentrations. The results showed a statistically significant difference between this group compared with a control group of healthy volunteers. We could not detect any increase in the sensitivity during repeated provocations.
authors.affiliation: Department of Otorhinolaryngology, Södersjukhuset, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Ohm
authors.forename: J E
authors.initials: JE
authors.lastname: Juto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000503:physiopathology; D009299:Nasal Provocation Tests; D012220:Rhinitis / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D006632:Histamine