Cardiac weight in hypertension induced by nitric oxide synthase blockade.
Wistar rats given a nitric oxide synthase inhibitor, NG-nitro-L-arginine-methyl ester (L-NAME), for 4 weeks develop time- and dose-dependent hypertension without cardiac hypertrophy. This initial study of the relation between left ventricular weight and L-NAME-induced hypertension has now been extended by giving 50 mg/kg per day L-NAME to Wistar rats (n = 30) for 8 weeks and comparing results with those from control rats (n = 10) and two-kidney, one clip rats (n = 14). Although L-NAME rats and two-kidney, one clip rats had increased systolic blood pressures during the last 3 weeks of the experiment (202 +/- 24 and 224 +/- 16 mm Hg, respectively), the ratio of left ventricular weight to body weight of L-NAME rats (2.12 +/- 0.32 mg/g) was not statistically different from that of control rats (1.93 +/- 0.13 mg/g), whereas that of two-kidney, one clip rats was increased (2.85 +/- 0.20 mg/g). The plasma renin activity of L-NAME rats was not significantly different from that of control rats. Two L-NAME rat subgroups were defined according to the presence of left ventricular hypertrophy (ratio of left ventricular weight to body weight > 2.19 mg/g, control mean +2 SD) (6 of 25) or its absence (19 of 25). Systolic blood pressure, plasma renin activity, and cardiac angiotensin converting enzyme activity of L-NAME rats with left ventricular hypertrophy were significantly higher than those of the subgroup without.(ABSTRACT TRUNCATED AT 250 WORDS)
Arnal
J F
JF
INSERM Unit 367, Paris, France.
el Amrani
A I
AI
Chatellier
G
G
Ménard
J
J
Michel
J B
JB
D000809:Angiotensins / Q000097:blood; D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006352:Heart Ventricles / Q000187:drug effects / Q000473:pathology; D006973:Hypertension / Q000139:chemically induced / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D009206:Myocardium / Q000473:pathology*; D019331:NG-Nitroarginine Methyl Ester; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D013997:Time Factors
D000809:Angiotensins; D009320:Atrial Natriuretic Factor; D001120:Arginine; D012083:Renin; D019331:NG-Nitroarginine Methyl Ester