[Immune-efficacy of recombinant vaccinia HB vaccine on middle school students of Uigur nationality].
Immunization efficacy of HB vaccine which is gene engineering vaccine of vaccinia virus recombinant was studied. A total of 206 middle school students of Uygur nationality in Hami, Xinjiang was vaccinated. A varying dosage of 10 micrograms, 5 micrograms, and 2.5 micrograms and 0, 1, 2 months schedule was carried out. The results showed that a seroconversion rate of 100%, 92.4% and 83.5%, in respect to 10 micrograms, 5 micrograms and 2.5 micrograms dosages were found while the mIU/ml values were 129.25, 132.27 and 121.18 respectively. The difference between seroconversion rates of 10 micrograms and 2.5 micrograms was significant (P < 0.05), whereas, that between conversion rate due to 10 micrograms and 5 micrograms was not (P > 0.05). Results in a year after primary immunization showed seroconversion rates of the three groups being 97.10%, 89.80% and 76.00% (P < 0.05); mIU/ml value were 151.0, 95.2 and 71.6 (P < 0.01), showing that the 10 micrograms group gave superior results to the 5 micrograms and 2.5 micrograms groups.
Li
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Hami Hongxing Hospital, Xinjiang.
D000293:Adolescent; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D008297:Male; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic