A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins.
We have previously used exon amplification to identify the ADD1 gene in cosmid Y24 from the Huntington's disease (HD) region of 4p16.3. The same technique has now yielded a second gene from this cosmid. This gene appears to encode a novel member of a superfamily of transporter proteins that includes active and passive transporters in a number of species. The predicted protein of 455 amino acids displays sequence similarity with the E. coli tetracycline resistance efflux protein encoded by cloning vector pBR322, and with a number of related transporters. This gene should open a route to isolating additional mammalian members of this growing superfamily.
Duyao
M P
MP
Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston.
Taylor
S A
SA
Buckler
A J
AJ
Ambrose
C M
CM
Lin
C
C
Groot
N
N
Church
D
D
Barnes
G
G
Wasmuth
J J
JJ
Housman
D E
DE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4; D004926:Escherichia coli / Q000235:genetics*; D005091:Exons; D015723:Gene Library; D005796:Genes; D005798:Genes, Bacterial; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D011323:Primates / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013753:Tetracycline Resistance / Q000235:genetics; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D026901:Membrane Transport Proteins; D012097:Repressor Proteins; D000099291:Adducins; C519998:MFSD10 protein, human; C034811:tetracycline resistance-encoding transposon repressor protein