title: Cocaine depresses cerebral glucose utilization in fetal sheep.
abstract: To assess if cocaine alters cerebral glucose metabolism in the fetus, we infused cocaine 0.6 mg/min intravenously to 6 of 13 fetal sheep for the 55 min prior to measurement of glucose utilization by an autoradiographic method. Overall, local cerebral glucose utilization (LCGU) was lower in cocaine-exposed fetuses than in 7 controls (P = 0.058). In the cocaine-exposed fetuses, 33 of 34 structures had lower mean LCGU than in the comparable structures of control fetuses. In addition, the autoradiographs in 4 of 6 cocaine-exposed fetuses revealed thin, dark lines of increased glucose utilization within the central white matter of some frontal gyri which were not seen in any of the 7 control fetuses. These lines were distributed similarly to ones seen earlier in severely hypoxic newborn lambs. In fetal lambs, cocaine resulted in a generalized decrease in LCGU and a specific increase in glucose utilization in parts of cortical white matter of the frontal gyri, possibly secondary to local ischemia.
authors.affiliation: Department of Pediatrics, University of Florida, Gainesville 32610.
authors.forename: D J
authors.initials: DJ
authors.lastname: Burchfield
authors.forename: R M
authors.initials: RM
authors.lastname: Abrams
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000196:embryology; D001923:Brain Chemistry / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D005260:Female; D005947:Glucose / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000473:pathology; D007262:Infusions, Intravenous; D011247:Pregnancy; D012756:Sheep
chemical_list: D003042:Cocaine; D005947:Glucose