title: Possible antifertility agents belonging to substituted indoles.
abstract: Of the 21 compounds evaluated for antiimplantation and abortifacient activities, compounds (A1, A2, A4 and B1) and compounds (C1, C2, D1 and D3) were found to exhibit 40% and 30% antiimplantation activity, respectively, in female rats when given orally on days 1-5 postcoitum. The remaining 13 compounds were found to be inactive. All of the 21 compounds were also tested for the abortifacient activity, but all were found to be inactive.
authors.affiliation: Department of Chemistry, Gulbarga University, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Hiremath
authors.forename: A C
authors.initials: AC
authors.lastname: Bajji
authors.forename: S H
authors.initials: SH
authors.lastname: Rao
mesh_terms: D000019:Abortifacient Agents / Q000737:chemistry; D000818:Animals; D003281:Contraceptives, Postcoital / Q000737:chemistry; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013723:Teratogens / Q000633:toxicity
chemical_list: D000019:Abortifacient Agents; D003281:Contraceptives, Postcoital; D007211:Indoles; D013723:Teratogens