title: Sneddon's syndrome and phospholipid antibodies.
abstract: We present a case of Sneddon's syndrome with high titers of antiphospholipid antibodies (APLA), in which the leading symptom was an incapacitating memory defect. MRI revealed vasculitic lesions of the central nervous system (CNS). Therefore immunosuppressive therapy was started with steroids and cyclophosphamide pulses. The transient beneficial effects of such a therapy will be discussed.
authors.affiliation: Department of Rheumatology and Clinical Immunology, University of Freiburg Medical Center, Freiburg, Germany.
authors.forename: H A
authors.initials: HA
authors.lastname: Mesa
authors.forename: B
authors.initials: B
authors.lastname: Lang
authors.forename: M
authors.initials: M
authors.lastname: Schumacher
authors.forename: P
authors.initials: P
authors.lastname: Vaith
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000209:etiology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000209:etiology; D017445:Skin Diseases, Vascular / Q000150:complications / Q000276:immunology* / Q000523:psychology; D013577:Syndrome
chemical_list: D017152:Antibodies, Antiphospholipid; D003520:Cyclophosphamide