title: Oral ciprofloxacin for treatment of severe infections.
abstract: Twenty adult patients with severe infections were treated with oral ciprofloxacin, 500 or 750 mg twice daily. Treatment ranged from 8 to 25 days. Efficacy was good: 14 patients (70%) were cured, four (20%) improved and there were only two (10%) failures. Tolerance was very satisfactory, the most common side-effects being mild gastrointestinal symptoms (three patients). Only one adverse laboratory result was observed: a transient rise in blood urea nitrogen and creatinine levels. None of the adverse effects led to discontinuation of treatment. Thus, ciprofloxacin presents as a promising drug for treatment of severe infections caused by susceptible organisms when ambulatorial therapy, at least during a large part of the treatment, is possible and desirable.
authors.affiliation: Hospital do Servidor Público Estadual, Sâo Paulo, Brazil.
authors.forename: I M
authors.initials: IM
authors.lastname: Lobo
authors.forename: N F
authors.initials: NF
authors.lastname: Silva
authors.forename: M C
authors.initials: MC
authors.lastname: Assef
authors.forename: C
authors.initials: C
authors.lastname: Mangini
authors.forename: M L
authors.initials: ML
authors.lastname: Silva
authors.forename: M L
authors.initials: ML
authors.lastname: Bortoletto
authors.forename: J S
authors.initials: JS
authors.lastname: Mendonça
authors.forename: G C
authors.initials: GC
authors.lastname: Levi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000188:drug therapy; D001424:Bacterial Infections / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011446:Prospective Studies; D012871:Skin Diseases / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D002939:Ciprofloxacin