title: Absorption of zidovudine in patients with diarrhoea.
abstract: Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentration and AUC after a single oral dose of 200 mg, were the same as those reported in 6 healthy male volunteers (3.1 vs 4.0 mumol.l-1 and 7.2 vs 5.2 mumol.h.l-1, respectively). Since the bioavailability of zidovudine is not particularly impaired, oral zidovudine therapy can be maintained in patients with diarrhoea.
authors.affiliation: Department of Clinical Pharmacy, Bicetre Hospital, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Zorza
authors.forename: L
authors.initials: L
authors.lastname: Beaugerie
authors.forename: A M
authors.initials: AM
authors.lastname: Taburet
authors.forename: Y
authors.initials: Y
authors.lastname: Le Quintrec
authors.forename: E
authors.initials: E
authors.lastname: Singlas
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000378:metabolism*; D000328:Adult; D001682:Biological Availability; D002908:Chronic Disease; D003967:Diarrhea / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D015215:Zidovudine / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*
chemical_list: D015215:Zidovudine