[Phospholipid antibodies (lupus anticoagulant and cardiolipin antibodies). Detection and clinical significance].
Phospholipid antibodies may be detected by their ability to prolong phospholipid dependent coagulation tests, and are then called lupus anticoagulants. When ELISA tests with cardiolipin as coating antigen are used, the term anticardiolipin antibodies is employed. The association with thrombosis is best documented in patients with systemic lupus erythematosus. However, the "antiphospholipid syndrome", i.e. repeated thrombotic episodes and/or foetal loss in combination with a high positive anticardiolipin antibody test and/or an unequivocally positive lupus anticoagulant test, may be seen in individuals without any known underlying disease. The article describes techniques for the detection of antiphospholipid antibodies and adequate processing and handling of plasma samples.
Wisløff
F
F
Hematologisk forskningslaboratorium, Ullevål sykehus, Oslo.
Sletnes
K E
KE
Schjetlein
R
R
D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology*; D008875:Middle Aged
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor
Fosfolipidantistoffer (lupusantikoagulant og kardiolipinantistoffer). Påvisning og klinisk betydning.