title: Increase in platelet count following short course therapy with recombinant alpha-2b-interferon in immune thrombocytopenic purpura in childhood.
abstract: Two boys, aged three and seven years with immune thrombocytopenic purpura continued to show platelet counts below 20,000/mm3 inspite of treatment with high dose gammaglobulin and steroids. Alpha-2b-interferon injections were followed by normalisation of platelet counts in both patients. No side effects were seen. Alpha-interferon may be a safe and effective treatment for childhood-ITP.
authors.affiliation: Children's Hospital, Philipp's University, Marburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Behrenbeck
authors.forename: F
authors.initials: F
authors.lastname: Riedel
authors.forename: C H
authors.initials: CH
authors.lastname: Rieger
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000628:therapy*; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins