title: Signal transduction events leading to T-cell lymphokine gene expression.
abstract: The expression of T-cell derived lymphokines is regulated by signal transduction events initiated by the T-cell antigen receptor and other T-cell surface molecules. Substantial progress has been made in characterizing the signal transduction events initiated at the plasma membrane of the T cell and their targets which control lymphokine gene expression in the nucleus. This review will summarize recent progress in this area of investigation.
authors.affiliation: Dept of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143.
authors.forename: J D
authors.initials: JD
authors.lastname: Fraser
authors.forename: D
authors.initials: D
authors.lastname: Straus
authors.forename: A
authors.initials: A
authors.lastname: Weiss
mesh_terms: D000818:Animals; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D008222:Lymphokines / Q000235:genetics*; D010750:Phosphoproteins / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008222:Lymphokines; D010750:Phosphoproteins; D011948:Receptors, Antigen, T-Cell