Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11.
Flynn
G A
GA
Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
Beight
D W
DW
Mehdi
S
S
Koehl
J R
JR
Giroux
E L
EL
French
J F
JF
Hake
P W
PW
Dage
R C
RC
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D015260:Neprilysin / Q000037:antagonists & inhibitors / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D011487:Protein Conformation; D051381:Rats; D011918:Rats, Inbred SHR; D013329:Structure-Activity Relationship; D013566:Sympathomimetics / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; D013566:Sympathomimetics; D015260:Neprilysin