Peripheral endotoxin induces hypothalamic immunoreactive interleukin-1 beta in the rat.
Interleukin-1 (IL-1) is a polypeptide produced by a variety of cells and contributes to the general host response to inflammation. It displays a wide spectrum of inflammatory, metabolic, physiological, haematopoietic and immunological activities. Brain cells, including neurones, microglia, endothelial cells and astrocytes can all produce IL-1 beta in response to various physiological and pathological stimuli. In this report we show that peripherally administered endotoxin stimulates the appearance of immunoreactive IL-1 beta (IL-1 beta) in the rat hypothalamus as measured by an ultrasensitive, highly specific enzyme amplified immunometric assay for rat IL-1 beta.
Hillhouse
E W
EW
Department of Clinical Biochemistry, School of Biomedical and Biomolecular Sciences, University of Newcastle, Newcastle upon Tyne.
Mosley
K
K
D000818:Animals; D000918:Antibody Specificity; D004731:Endotoxins / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007118:Immunoassay; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical
D004731:Endotoxins; D007375:Interleukin-1