[The new antidepressant tetrindole].
The antidepressive effects of tetrindole versus pyrazidole (pirlindole) and imipramine were studied in animal experiments. Tetrindole was found to be more active than pyrazidole and imipramine in a behavioral model of Porsolt, in antagonism with reserpine, in potentiation with 5-hydroxytryptophan, L-dopa and clonidine. The action of terindole is related to its ability to exert reversible inhibitory effects on MAO A activity. Tetrindole is less toxic than pyrazidole and imipramine.
Mashkovskiĭ
M D
MD
Glushkov
R G
RG
Shvedov
V I
VI
Andreeva
N I
NI
Golovina
S M
SM
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000633:toxicity; D001362:Avoidance Learning / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology* / Q000633:toxicity; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D017079:Exercise Tolerance / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology; D007928:Lethal Dose 50; D008568:Memory / Q000187:drug effects; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013550:Swimming
D000928:Antidepressive Agents; D002227:Carbazoles; D008996:Monoamine Oxidase Inhibitors; C082644:tetrindole; D007099:Imipramine; C009830:pirlindole
Novyĭ antidepressant tetrindol.