[Immunologic diagnosis and treatment in the cases of unexplained habitual abortion].
One hundred and fourty-eight cases of habitual abortion were screened for etiologies. We found 40.5% (60/148) were unexplained. Among them, 34 cases were volunteers for receiving repeated active immunolization with low-dose of lymphocyte from their husbands or other donors, and 12 cases were taken as control. The successful pregnant rate was 86.4% (19/22) in treatment group which is higher significantly than in control (P < 0.05). meanwhile, used by microlymphocytotoxic antibody test and one-way mixed lymphocyte reaction and its inhibition test, the observations on immunologic state before and after vaccination were made in 19 cases. We found both the positive rate of microlymphocytotoxic antibody test and the relative suppressive rate of lymphocyte response were increased significantly post-vaccination than pre-vaccination. These results not only confirmed that active immunization was effective, but also suggested that habitual abortion may be associated with the lack of protective antibody and/or block antibody.
Lin
Q D
QD
Ren Ji Hospital of Shanghai Second Medical University.
D000026:Abortion, Habitual / Q000175:diagnosis* / Q000628:therapy*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011247:Pregnancy