title: Gingival crevicular blood for assessment of blood glucose in diabetic patients.
abstract: In this study 50 patients with diabetes mellitus had gingival crevicular blood from periodontal probing collected in small plastic pipettes. The pipettes transferred the crevicular blood to a non-wipe glucose self-monitoring instrument. At the same time, finger-stick capillary blood measurements were analyzed in the same glucose self-monitoring instrument, and venous blood was collected for measurement in a laboratory glucose analyzer. Each laboratory measurement was corrected from a serum glucose value to a whole blood glucose value by a function of the patient's hematocrit. This corrected glucose value allowed direct comparison of the laboratory measurement to the intraoral and finger-stick whole blood measurements. The patient blood glucose concentrations ranged from 59 mg/dl to 366 mg/dl. The gingival crevicular blood exhibited a correlation of r = 0.975 (P < .0001) to the corrected laboratory standard measurement, with a mean prediction error (bias) of -4.11 mg/dl and a root mean square error (precision) of 17.43 mg/dl. The finger-stick blood had a correlation of r = 0.983 (P < .0001) to the corrected laboratory standard, with a mean prediction error of 4.65 mg/dl and a root mean square error of 14.48 mg/dl. The American Diabetic Association recommends that the prediction error of blood glucose monitoring devices fall within 15% of the laboratory standard. Using this criterion 92% of the gingival crevicular measurements and 90% of the finger-puncture measurements fell within 15% of the laboratory value.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Periodontics, University of Missouri-Kansas City, School of Dentistry.
authors.forename: R C
authors.initials: RC
authors.lastname: Parker
authors.forename: J W
authors.initials: JW
authors.lastname: Rapley
authors.forename: W
authors.initials: W
authors.lastname: Isley
authors.forename: P
authors.initials: P
authors.lastname: Spencer
authors.forename: W J
authors.initials: WJ
authors.lastname: Killoy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015982:Bias; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation* / Q000592:standards; D001800:Blood Specimen Collection / Q000295:instrumentation / Q000379:methods*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D005881:Gingiva / Q000098:blood supply*; D005884:Gingival Hemorrhage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose