Absence of brain antibodies in the sera of relapsing-remitting multiple sclerosis patients is not due to the formation of immune complexes.
Using an enzyme-linked immunoadsorbent assay, we looked, whether the formation of idiotype-anti-idiotype complexes was responsible for the absence of antibodies in the sera of MS patients. We tested 18 relapsing-remitting and 26 chronic progressive patients versus 44 age- and sex-matched controls. We did not find elevated titres of immune complexes in the sera of the multiple sclerosis patients.
Henneberg
A E
AE
Department of Neurology, University of Ulm, Germany.
Elsner
U
U
Kornhuber
H H
HH
D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000276:immunology*; D015922:Complement C1q / Q000276:immunology; D015933:Complement C3d / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D015922:Complement C1q; D015933:Complement C3d