title: In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid.
abstract: We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isolates were susceptible to < or = 0.25 microgram of ceftriaxone per ml, < or less 0.5 microgram of cefixime per ml, < or = 0.125 microgram of ciprofloxacin per ml, and < or = 0.06 microgram of ofloxacin per ml. Erythromycin was active against all isolates (MIC for 90% of isolates tested, 0.25 microgram/ml), as was azithromycin (MIC, < or = micrograms/ml). In contrast, all but one isolate were resistant to > or = 8.0 micrograms of tetracycline per ml, 11.1% of the isolates were resistant to and 40.9% of the isolates were resistant to trimethoprim-sulfamethoxazole (MIC, > or = 4/76 microgram/ml.)
authors.affiliation: Division of Sexually Transmitted Diseases Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
authors.forename: J S
authors.initials: JS
authors.lastname: Knapp
authors.forename: A F
authors.initials: AF
authors.lastname: Back
authors.forename: A F
authors.initials: AF
authors.lastname: Babst
authors.forename: D
authors.initials: D
authors.lastname: Taylor
authors.forename: R J
authors.initials: RJ
authors.lastname: Rice
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D002602:Chancroid / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D004917:Erythromycin / Q000494:pharmacology; D006191:Haemophilus ducreyi / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013785:Thailand / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D002443:Ceftriaxone