title: Lithium-induced nephrogenic diabetes insipidus treated with indomethacin.
abstract: NDI occurs in 5% to 20% of patients receiving long-term lithium therapy. The associated polyuria usually resolves within 3 weeks of lithium discontinuance but can persist beyond a year. For such patients, hydrochlorothiazide and amiloride therapy has been hampered by the delayed effect and intrinsic side effects of these agents. We have described the case of a 66-year-old man with a history of bipolar disorder treated with lithium who was transferred to the intensive care unit with coma. Indomethacin therapy, at a dose of 50 mg every 8 hours, was begun and improvement of the NDI state was observed within 3 hours of lithium administration. There was complete normalization of mental status and laboratory studies after 36 hours. A complete 3-week course of indomethacin was required to keep the patient free of symptoms of NDI. We have also discussed the role of indomethacin in reversing lithium-induced NDI and reviewed pertinent prior reports in the literature.
authors.affiliation: Department of Medicine, University of South Florida, College of Medicine, Tampa.
authors.forename: E J
authors.initials: EJ
authors.lastname: Martinez
authors.forename: J T
authors.initials: JT
authors.lastname: Sinnott
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez-Paz
authors.forename: R L
authors.initials: RL
authors.lastname: Oehler
mesh_terms: D000208:Acute Disease; D000368:Aged; D003919:Diabetes Insipidus / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy; D016651:Lithium Carbonate / Q000009:adverse effects*; D008297:Male
chemical_list: D016651:Lithium Carbonate; D007213:Indomethacin