title: Prostaglandin biosynthesis inhibitory activity of some indian-1 acids in relation to their anti-inflammatory activity and ulcerogenic potency.
abstract: Continuation of our work towards development of some newer non-steroidal anti-inflammatory agents led us to some substituted indian-1-acids with low ulcerogenic liability. Prostaglandin biosynthesis inhibitory activity of these indian acids and their acid dissociation constants were evaluated in view of their activity profile.
authors.affiliation: Department of Chemical Technology, Calcutta University, India.
authors.forename: A
authors.initials: A
authors.lastname: Mukhopadhyay
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.forename: S C
authors.initials: SC
authors.lastname: Lahiri
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D015232:Dinoprostone / Q000096:biosynthesis*; D006168:Guinea Pigs; D007189:Indans / Q000494:pharmacology* / Q000633:toxicity; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007189:Indans; D015232:Dinoprostone