title: Destructive spondyloarthropathy in a patient on continuous ambulatory peritoneal dialysis for 13 years.
abstract: Since 1984 there have been reports of a destructive spondyloarthropathy occurring in patients on long-term hemodialysis. The primary abnormality appears to be an accumulation of beta 2-microglobulin, which is not adequately removed by dialysis, and forms amyloid deposits in articular and periarticular tissues. We report a case of this disease in a patient treated only by peritoneal dialysis. While this form of treatment may delay the development of arthropathy, as compared to hemodialysis, it does not prevent it. An increasing incidence of this disorder may be expected, since increasing numbers of patients have been on long-term peritoneal dialysis.
authors.affiliation: Divisions of Nephrology, Toronto Hospital, Ontario, Canada.
authors.forename: G E
authors.initials: GE
authors.lastname: Digenis
authors.forename: G
authors.initials: G
authors.lastname: Davidson
authors.forename: N V
authors.initials: NV
authors.lastname: Dombros
authors.forename: A
authors.initials: A
authors.lastname: Katz
authors.forename: A
authors.initials: A
authors.lastname: Bookman
authors.forename: D G
authors.initials: DG
authors.lastname: Oreopoulos
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology; D002574:Cervical Vertebrae / Q000737:chemistry; D005260:Female; D006801:Humans; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D013122:Spinal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D001613:beta 2-Microglobulin