[Interaction of midazolam and thiopental in amnestic effect].
Interaction of midazolam and thiopental in amnestic effect was studied in 30 adult patients who underwent elective surgery of lower extremities under epidural or spinal anesthesia in combination with oxygen, nitrous oxide and low concentration of sevoflurane. Combination of midazolam 2.0-3.0 mg (0.041 +/- 0.006 mg.kg-1) and thiopental 3-5 mg.kg-1 produced amnestic effect in 87% of patients. No side effects, such as decrease in O2 saturation, upper airway obstruction, cardiovascular depression and delayed emergence were observed with this small dose of midazolam. Administration of midazolam 2.0-3.0 mg before epidural, or spinal anesthesia in the operating room under observation of anesthesiologists, followed by thiopental 3-5 mg.kg-1, was safe and comfortable to the patients.
Koyama
K
K
Department of Anesthesiology, Saitama Medical Center, Saitama Medical School, Kawagoe.
Katayama
A
A
Yamada
T
T
Miyao
H
H
Kawasaki
J
J
Kawazoe
T
T
D000328:Adult; D000767:Anesthesia, Epidural; D000775:Anesthesia, Spinal; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D013514:Surgical Procedures, Operative / Q000523:psychology*; D013874:Thiopental / Q000494:pharmacology*
D013874:Thiopental; D008874:Midazolam