title: Endothelin-1-induced gastric ulcer is attenuated by cetraxate.
abstract: We investigated the effect of the anti-ulcer drug cetraxate on the development of the gastric ulcer induced by the submucosal injection of endothelin-1 in the rat gastric body, and its effects on gastric mucosal hemodynamics and tissue oxygenation by Laser doppler flowmetry and tissue spectrophotometry. Endothelin-1 induced gastric ulcer (ulcer length: 11.85 +/- 0.89 mm, mean +/- SEM, n = 4) which was strongly attenuated by cetraxate (ulcer length: 3.27 +/- 0.3 mm, mean +/- SEM, n = 8, p < 0.0001). Cetraxate maintained also tissue oxygenation without causing any significant effect on the endothelin-1-induced changes in gastric mucosal blood flow and volume. These results show that cetraxate exerts its cytoprotective action partly by maintaining mucosal oxygenation.
authors.affiliation: Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Lazaratos
authors.forename: H
authors.initials: H
authors.lastname: Kashimura
authors.forename: A
authors.initials: A
authors.lastname: Nakahara
authors.forename: H
authors.initials: H
authors.lastname: Fukutomi
authors.forename: T
authors.initials: T
authors.lastname: Osuga
authors.forename: T
authors.initials: T
authors.lastname: Miyauchi
authors.forename: K
authors.initials: K
authors.lastname: Goto
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D016232:Endothelins / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy*; D014148:Tranexamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000897:Anti-Ulcer Agents; D016232:Endothelins; C000665:cetraxate; D014148:Tranexamic Acid