[Induction of synthesis of extracellular DNAase from Proteus mirabilis under the effect of compounds, blocking DNA replication].
The effects of mitomycin C and nalidixic acid on the biosynthesis of extracellular endodeoxyribonuclease in Proteus mirabilis have been studied. The presence of both antibiotics in the periodic and short-time cultures of washed off cells has increased both the activity of the DNAse and protein yield in cultural liquid and bacterial cells. PAGE-electrophoresis has shown the effect of mitomycin C to increase or induce the synthesis a large number of Proteus mirabilis extracellular proteins.
Iusupova
D V
DV
Sanzhmiatavyn
E
E
Sokolova
R B
RB
Petukhova
E V
EV
D004261:DNA Replication / Q000187:drug effects*; D003851:Deoxyribonucleases / Q000096:biosynthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D004790:Enzyme Induction; D016685:Mitomycin / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology*
D009268:Nalidixic Acid; D016685:Mitomycin; D003851:Deoxyribonucleases
Induktsiia sinteza vnekletochnoĭ DNKazy Proteus mirabilis pod vliianiem soedineniĭ, blokiruiushchikh replikatsiiu DNK.