Okadaic acid inhibits insulin stimulation of both ornithine decarboxylase and spermidine transport in hepatocyte cultures.
1. Okadaic acid inhibited basal ODC activity in rat hepatocytes in culture and prevented any increase in ODC activity and in the rate of spermidine uptake promoted by both insulin and hypotonicity. 2. The increase promoted by AIB was not counteracted by okadaic acid.
Colombatto
S
S
Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italy.
Grillo
M A
MA
D000818:Animals; D002478:Cells, Cultured; D004988:Ethers, Cyclic / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019319:Okadaic Acid; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D065108:Ornithine Decarboxylase Inhibitors; D051381:Rats; D013095:Spermidine / Q000378:metabolism*
D004988:Ethers, Cyclic; D007328:Insulin; D065108:Ornithine Decarboxylase Inhibitors; D019319:Okadaic Acid; D009955:Ornithine Decarboxylase; D013095:Spermidine