title: Analytical approaches to genomic evolution.
abstract: We model the non-local mechanisms of genomic evolution and propose methods for studying the evolutionary divergence of species based on these models. Mechanisms include the movement of segments of genomes within a single chromosome (transpositions), the reciprocal translocation of segments between two chromosomes, and the inversion of segments. Each of these is studied in the context of a different type of genomic data. We introduce the theory of phylogenetic invariants for evolutionary inference based on very long macromolecular sequences.
authors.affiliation: Université de Montréal, Centre de Recherches Mathématiques, Montréal, Québec, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Sankoff
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004272:DNA, Mitochondrial / Q000235:genetics; D016678:Genome; D006801:Humans; D051379:Mice; D008928:Mitochondria; D008957:Models, Genetic; D009154:Mutation; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014178:Translocation, Genetic
chemical_list: D004272:DNA, Mitochondrial