Verucopeptin, a new antitumor antibiotic active against B16 melanoma. II. Structure determination.
The structure of a new antibiotic verucopeptin has been determined by the spectroscopic analyses and chemical degradation studies. It is a 19-membered cyclodepsipeptide which is structurally related to azinothricin and A83586C.
Sugawara
K
K
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Toda
S
S
Moriyama
T
T
Konishi
M
M
Oki
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology; D047630:Depsipeptides; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010456:Peptides, Cyclic; C082424:verucopeptin