Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes.
Programmed cell death (apoptosis) is triggered in immature thymocytes and T-cell hybridomas by signalling via the CD3-T-cell receptor pathway. In this paper, Dieter Kabelitz and colleagues catalogue the recently accumulating evidence that apoptosis can also be initiated in mature peripheral T cells; this may constitute an important aspect of cellular immune regulation.
Kabelitz
D
D
Paul-Ehrlich Institute, Dept of Immunology, Langen, Germany.
Pohl
T
T
Pechhold
K
K
D000486:Allergy and Immunology / Q000639:trends; D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D017252:CD3 Complex; D002454:Cell Differentiation; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell