title: Circulating immune complexes in Hodgkin's disease. Reactivity of IgG isolated from circulating immune complexes.
abstract: In our earlier report on circulating immune complexes (CIC) from sera of patients with Hodgkin's disease (HD), we demonstrated disease-associated increase in the intensity of a 40kD (pl 5.6) polypeptide in the CIC. In extension of these investigations, we now report that the 40kD moiety exists in CIC as a complex with IgG, and that IgG isolated from such CIC samples from sera of patients with HD shows preferential reactivity with the typical large binucleate Reed-Sternberg (R-S) cells in the sections of disease-involved lymph nodes from HD patients.
authors.affiliation: Biological Chemistry Division, Cancer Research Institute, Parel, Bombay, India.
authors.forename: A V
authors.initials: AV
authors.lastname: Nerurkar
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
authors.forename: B P
authors.initials: BP
authors.lastname: Gothoskar
mesh_terms: D000912:Antibodies, Neoplasm / Q000276:immunology* / Q000302:isolation & purification; D000936:Antigen-Antibody Complex / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000302:isolation & purification; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000276:immunology* / Q000302:isolation & purification; D016539:Reed-Sternberg Cells / Q000276:immunology
chemical_list: D000912:Antibodies, Neoplasm; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D007074:Immunoglobulin G