Growth factors and wound healing.
BACKGROUND
Over the last decade, there has been an exponential increase in our knowledge of the biology of growth factors. The hope has been and remains that these potent biologic agents will effect a fundamental improvement in the way we treat wounds.


OBJECTIVE
We will discuss the biology of growth factors and the dramatic effects these proteins have on cell proliferation, cell chemotaxis, and on the formation of extracellular matrix molecules.


RESULTS
Growth factors are extremely potent biologic agents that show promise in accelerating wound repair in both animal and human studies. They improve granulation tissue, enhance tensile strength, and promote reepithelialization. Cosmetic effects are also to be expected by antagonizing and blocking the action of these peptides.


CONCLUSIONS
Growth factors are likely to become an important therapeutic tool for the dermatologic surgeon.
Falanga
V
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Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida.
D000818:Animals; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D014945:Wound Healing / Q000502:physiology*
D006133:Growth Substances