title: Simultaneous presentation of symptomatic subependymomas in siblings: case reports and review.
abstract: Two young adult siblings independently developed similar neurological complaints that included headaches, photophobia, nausea, and intermittent lancinating facial pains. Magnetic resonance imaging revealed fourth ventricular lesions that required surgery in both patients. A pathological review revealed subependymomas with virtually identical histological features. The clinical features and common pathological findings of both patients suggest that familial subependymomas may have a maldevelopmental origin with genetic implications.
authors.affiliation: Department of Neurologic Surgery, Mayo Clinic, Mayo Medical School, Rochester, Minnesota.
authors.forename: T M
authors.initials: TM
authors.lastname: Cheng
authors.forename: R J
authors.initials: RJ
authors.lastname: Coffey
authors.forename: B R
authors.initials: BR
authors.lastname: Gelber
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D001933:Brain Stem; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D009857:Oncogenes; D010375:Pedigree