[Does the administration of derivatives of vitamin D to dairy cows in late pregnancy for the prevention of parturient paresis affect the maternal-fetal mineral metabolism?].
Intramuscular injection of 1 alpha-hydroxyvitamin D3 (with or without 25-hydroxyvitamin D3) to highly pregnant dairy cows caused a significant increase of ionized calcium in blood and of total calcium and inorganic phosphate with a concomitant decrease of magnesium in blood plasma 3,5 +/- 1,9 days later (resp. 12-48 h a.p.). This brought about a higher Ca level at parturition preventing parturient paresis. The changes of maternal mineral and vitamin D status had no effect on the mineral concentrations of blood in newborn calves. However, the increase in calcium and phosphate concentrations in maternal blood after injection was accompanied by an increase of the minerals in the amniotic fluid reflecting their strong reciprocal exchange. On the other hand, the composition of allantoic fluid showed no significant changes. Therefore, analysis of both fetal fluids does not refer to disorders of fetal mineral metabolism. As a consequence, there seems to be no potential risk of intoxication after a prepartal injection of the substances to the mother for their offspring.
Zepperitz
H
H
Tierärztliche Gemeinschaftspraxis Neubukow, Universität, Leipzig.
Grün
E
E
D000818:Animals; D002112:Calcifediol / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D006887:Hydroxycholecalciferols / Q000494:pharmacology / Q000627:therapeutic use*; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D008903:Minerals / Q000378:metabolism*; D010319:Parturient Paresis / Q000517:prevention & control*; D011247:Pregnancy
D004338:Drug Combinations; D006887:Hydroxycholecalciferols; D008903:Minerals; D002112:Calcifediol; C008088:alfacalcidol
Hat die Verabreichung von Derivaten des Vitamin D an hochträchtige Milchkühe zur Prophylaxe der Gebärparese Auswirkungen auf den maternal-fetalen Mineralstoff-wechsel?