Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.
Recent studies have demonstrated that a locus at 11p15.5 confers susceptibility to insulin dependent diabetes mellitus (IDDM). This locus has been shown to lie within a 19 kb region. We present a detailed sequence comparison of the predominant haplotypes found in this region in a population of French Caucasian IDDM patients and controls. Identification of polymorphisms both associated and unassociated with IDDM has allowed us to define further the region of association to 4.1 kb. Ten polymorphisms within this region are in strong linkage disequilibrium with each other and extend across the insulin gene locus and the variable number tandem repeat (VNTR) situated immediately 5' to the insulin gene. These represent a set of candidate disease polymorphisms one or more of which may account for the susceptibility to IDDM.
Lucassen
A M
AM
Molecular Immunology group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Julier
C
C
Beressi
J P
JP
Boitard
C
C
Froguel
P
P
Lathrop
M
M
Bell
J I
JI
D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D015804:HLA-DR4 Antigen; D007328:Insulin; D004247:DNA