title: University of Wisconsin preservation solution compared with Euro Collins preservation solution in pediatric liver transplantation.
abstract: Orthotopic liver transplantation has become the accepted treatment for end-stage liver disease in children. To evaluate the efficacy of the University of Wisconsin (UW) preservation solution in pediatric liver transplantation, a group of 34 livers preserved with UW solution was compared in a nonrandomized fashion with a historical control group of 34 livers preserved with Euro Collins (EC) solution. Primary graft nonfunction did not occur in either group. Both groups were similar with respect to age, sex, weight, diagnosis, severity of the recipient's condition, donor condition at harvest, donor/recipient blood type match, and immunosuppressive management. The UW group had a significantly higher bilirubin, AST, ALT, and GGT during the first week after transplantation when compared with the EC group but no significant differences were noted after the ninth post-transplant day. No differences were noted when the groups were compared as to surgery time (9.1 v 8.4 hours), blood volumes replaced (1.8 v 2.0), number of ICU days (5.0 v 6.5), total number of infections per graft (1.0 v 0.8), total hospital days (31 v 30), and hospital cost ($134,000 v $126,000). The total preservation time was improved from 7 hours (range, 3.2 to 9.9) in the EC group to 13.9 hours (range, 6.9 to 22.3) in the UW group (P < .001). UW solution allows a significant increase in cold ischemic time in liver transplantation when compared with EC. This increase in preservation time resulted in no detrimental effect when compared with EC and potentially led to milder episodes of rejection in the postoperative period.
authors.affiliation: Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-8580.
authors.forename: T H
authors.initials: TH
authors.lastname: Renard
authors.forename: W S
authors.initials: WS
authors.lastname: Andrews
authors.forename: M G
authors.initials: MG
authors.lastname: Schlatter
authors.forename: C
authors.initials: C
authors.lastname: Conlin
mesh_terms: D000241:Adenosine; D000293:Adolescent; D000493:Allopurinol; D002648:Child; D002675:Child, Preschool; D005260:Female; D005978:Glutathione; D006084:Graft Rejection; D006801:Humans; D006982:Hypertonic Solutions; D007223:Infant; D007239:Infections / Q000209:etiology; D007328:Insulin; D008099:Liver / Q000503:physiopathology; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011183:Postoperative Complications; D011887:Raffinose
chemical_list: C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose