title: [Distribution of harringtonine positively and negatively charged liposome in rat tissues].
abstract: Distribution of harringtonine positively and negatively charged liposome (HL(+), HL(-)) and harringtonine free drug (FH) in rat tissues were measured by HPLC. Their LD50 in mice were compared. The results showed that distribution of HL(+), HL(-), In vivo may be changed, that the amount of HL(+), HL(-) was increased in the liver, lung, and spleen and in these tissues it was 2-30-fold higher than that of HF after iv 2 h. HL(+), HL(-) may aid to permeate through the blood-brain, blood-testicle barrier, and to reduce acute lethal toxicity. Areas under the time curve of HL(+), HL(-) in brain and testis within 2 h were 2-4.5 times as much as those of HF. There were significant differences in the fate between negatively and positively charged liposomes in vivo.
authors.affiliation: Nanjing Institute of Materia Medica, Nanjing, China.
authors.forename: H L
authors.initials: HL
authors.lastname: Wu
authors.forename: G Y
authors.initials: GY
authors.lastname: Weng
authors.forename: X M
authors.initials: XM
authors.lastname: Zhou
authors.forename: D D
authors.initials: DD
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001814:Blood-Testis Barrier; D004337:Drug Carriers; D005260:Female; D006248:Harringtonines / Q000493:pharmacokinetics* / Q000633:toxicity; D008081:Liposomes; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D006248:Harringtonines; D008081:Liposomes; C062500:harringtonin