Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge).
An isoprenyl guanidine, galegine, was isolated from the Western Australian sedge Schoenus asperocarpus (Cyperaceae). Synthetic galegine was shown to reproduce the clinical and pathological features of poisoning by this plant. Preliminary results suggest that the massive thoracic effusion observed in sedge poisoning is the result of a direct effect on pulmonary vascular permeability.
Huxtable
C R
CR
School of Veterinary Studies, Murdoch University, Western Australia.
Dorling
P R
PR
Colegate
S M
SM
D000818:Animals; D005260:Female; D006146:Guanidines / Q000302:isolation & purification / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010947:Plants, Toxic / Q000737:chemistry; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000473:pathology
D006146:Guanidines; C074315:galegine