title: Laryngeal imaging by computerized tomography and magnetic resonance following radiation therapy: a need for caution.
abstract: For patients with laryngeal tumours, the use of computerized tomography (CT) or magnetic resonance imaging (MR) may facilitate accurate staging by the demonstration of cartilage invasion or tumour extension to areas such as the pre-epiglottic space. The role of imaging in the follow-up of patients after radiotherapy, however, has not been examined. A prospective study of 18 patients undergoing laryngectomy was performed. The results of pre-operative CT and MR imaging were correlated with the pathological findings from whole organ axial sections of the laryngeal specimens. In five patients (28 per cent) both CT and MR images were significantly impaired by movement artefact. In the eight patients without previous radiotherapy, seven had adequate quality imaging and both CT and MR accurately demonstrated the site, size and extent of laryngeal tumour. In eight of the ten patients following radiation therapy the presence of tumour was correctly identified, however there was a poor correlation between the imaging and pathological findings. Two patients had radionecrosis alone. Neither CT nor MR imaging could differentiate between radionecrosis and recurrent tumour.
authors.affiliation: Institute of Laryngology and Otology, London.
authors.forename: R J
authors.initials: RJ
authors.lastname: Briggs
authors.forename: A P
authors.initials: AP
authors.lastname: Gallimore
authors.forename: P D
authors.initials: PD
authors.lastname: Phelps
authors.forename: D J
authors.initials: DJ
authors.lastname: Howard
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D007830:Larynx / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011446:Prospective Studies; D011832:Radiation Injuries / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed