Early and transient effects of neutron irradiation on dopamine receptors in the adult rat brain.
The early neurochemical effects of neutron-gamma radiation exposures were studied through ligand dopamine D1, D2 receptors binding experiments. The parameters of binding were investigated on crude preparations from striatum at different delays (from 2 to 72 hours) after irradiation. An early and transient increase in the total number of sites was seen after exposure, even at infra-lethal dose. This 'radiosensitivity' was higher for D1 than for D2 receptor. It is assumed that these modifications could participate in the early neuro-vegetative syndrome observed in irradiated persons.
Martin
C
C
Unité de Radioprotection, Centre de Recherches du Service de Santé des Armées, Grenoble, La Tronche, France.
Rubio
I
I
Fatome
M
M
D000818:Animals; D001552:Benzazepines / Q000378:metabolism; D001665:Binding Sites / Q000528:radiation effects; D001921:Brain / Q000378:metabolism*; D008297:Male; D009502:Neutrons; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000528:radiation effects*; D017448:Receptors, Dopamine D2 / Q000528:radiation effects*; D013134:Spiperone / Q000378:metabolism; D013997:Time Factors
D001552:Benzazepines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013134:Spiperone