Repeated alcohol intake changes circadian rhythm of ambulatory blood pressure.
The blood pressure of 7 clinically healthy volunteering social drinkers was studied while they consumed, with a crossover design for 5 days, either 40 g of alcohol by day or fruit juice, with the two spans on alcohol and juice being separated by a one-week washout. Whereas the rhythm-adjusted mean was not changed, a clear statistically significant increase in the circadian double amplitude was found. The study provides a model for a rapidly achieved circadian amplitude hypertension which may precede an elevation of the overall blood pressure mean in the natural course of the disease.
Kumagai
Y
Y
Chronobiology Laboratories, University of Minnesota.
Shiga
T
T
Sunaga
K
K
Fukushima
C
C
Cornélissen
G
G
Ebihara
A
A
Halberg
F
F
D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D003971:Diastole / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008991:Monitoring, Physiologic; D013599:Systole / Q000187:drug effects / Q000502:physiology
D000431:Ethanol