Historical control data of organ weight and gross findings in F344/DuCrj rats and B6C3F1 mice.
Organ weight and gross postmortem findings of control Fischer 344/DuCrj rats and B6C3F1 mice are presented from subchronic, chronic toxicity and carcinogenicity studies that were conducted over a 9 year period at our center (An-Pyo Center). The mean organ weight of the liver, kidney, spleen and the lung were increased associated with age in both species. The most common findings observed at 109 weeks in both species were thymic atrophy, enlargement of the spleen, dilation of the lumen of the uterus and ovarian cysts. Male and female Fischer 344/DuCrj rats commonly exhibited a granular surface of the kidneys, hypertrophy of and/or nodular pituitary glands and subcutaneous tissue masses. Multiple white patches and hypertrophy or atrophy of the testes, atrophy of the seminal vesicles and prostate and nodules in the pancreas were seen frequently in male rats. Malformative nodule in the liver was a common finding in female rats. The most common lesions seen in both male and female B6C3F1 mice were nodules in the liver and lungs and enlargement of the lymph nodes. Nodules on the preputial gland were commonly seen in the males. Sex differences were evident in the incidence of some of the above findings. These historical data will contribute to analyze the organ weight and gross findings at necropsy in long-term toxicity and carcinogenicity studies.
Iwata
H
H
Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan.
Hagiwara
T
T
Katoh
M
M
Yamamoto
S
S
Yamakawa
S
S
Shiga
A
A
Hirouchi
Y
Y
Kobayashi
K
K
Inoue
H
H
Enomoto
M
M
D000818:Animals; D000830:Animals, Laboratory; D001921:Brain / Q000473:pathology*; D015197:Carcinogenicity Tests / Q000662:veterinary; D005260:Female; D007668:Kidney / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008168:Lung / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D051381:Rats; D011916:Rats, Inbred F344; D012727:Sex Characteristics; D013154:Spleen / Q000473:pathology*; D014116:Toxicology