Lung injury by furanoterpenoids isolated from Fusarium solani infected sweet potato, Ipomea batatas.
Intraperitoneal administration (1 mg/kg body/wt./day for 21 days) of crude extract of furanoterpenoids, isolated from F. solani damaged I. batatas caused pulmonary oedema in albino rats. The elevated broncho alveolar lavage (BAL) angiotensin converting enzyme (ACE), lactate dehydrogenase (LDH) and protein levels indicated lung damage. The estimation of pulmonary extracellular surfactant phospholipids showed an alteration in various phospholipid fractions.
Parasakthy
K
K
Department of Biochemistry, University of Madras, India.
Shanthi
S
S
Devaraj
S N
SN
D000818:Animals; D005670:Fusarium / Q000502:physiology; D008168:Lung / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000633:toxicity*; D014675:Vegetables / Q000382:microbiology
D010936:Plant Extracts; D013729:Terpenes