Urinary oxalate and glycolate excretion patterns in the first year of life: a longitudinal study.
To determine the range of normal values, we studied urinary excretion of oxalate and glycolate prospectively and longitudinally in a cohort of 30 healthy term infants. Random urine samples were obtained at 2 days, 2 weeks, and 2, 4, 6, and 9 months of age. The results had a log-normal distribution. The mean oxalate/creatinine ratio, as determined by the oxalate oxidase method, was 0.08 (in milligrams of oxalate to milligrams of creatinine) with a normalized range of 0.02 to 0.31. The mean ratio when oxalates were measured by using the Olthuis assay was 0.13 (range 0.03 to 0.53). The mean glycolate/creatinine ratio was 0.07 (range 0.02 to 0.26). These values did not correlate with increasing age. The oxalate/creatinine ratios were higher in formula-fed infants than in those who were fed human milk (0.14 +/- 0.16 vs 0.08 +/- 0.04; p < 0.01).
Morgenstern
B Z
BZ
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota 55905.
Milliner
D S
DS
Murphy
M E
ME
Simmons
P S
PS
Moyer
T P
TP
Wilson
D M
DM
Smith
L H
LH
D003404:Creatinine / Q000652:urine*; D006016:Glycolates / Q000652:urine*; D006801:Humans; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008895:Milk, Human; D010070:Oxalates / Q000652:urine*; D011446:Prospective Studies; D012016:Reference Values
D006016:Glycolates; D010070:Oxalates; C031149:glycolic acid; D003404:Creatinine