title: 8;21 translocation and multilineage involvement.
abstract: The translocation (8;21)(q22;q22) is commonly associated with acute myeloid leukemia (AML) M2 according to the French-American-British (FAB) classification. We describe 11 cases of t(8;21) diagnosed by strict FAB criteria. Six cases were diagnosed as AML M2, 3 cases as AML M4, 1 case as refractory anemia with excess of blasts in transformation, and 1 case as Philadelphia chromosome negative chronic myeloid leukemia in acceleration. Translocation (8;21) could thus occur in a wider variety of hematological abnormalities. Accordingly, we propose that t(8;21) may involve different hemopoietic lineages.
authors.affiliation: University Department of Pathology, Queen Mary Hospital, Hong Kong.
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
authors.forename: L M
authors.initials: LM
authors.lastname: Ching
authors.forename: H W
authors.initials: HW
authors.lastname: Liu
authors.forename: C P
authors.initials: CP
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Pollock
authors.forename: L C
authors.initials: LC
authors.lastname: Chan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002648:Child; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic