title: [Genotoxic modification of nucleic acid bases and biological consequences of it. Review and prospects of experimental and computational investigations].
abstract: The review is presented of experimental and computational data on the influence of genotoxic modification of bases (deamination, alkylation, oxidation) on the structure and biological functioning of nucleic acids. Pathways are discussed for the influence of modification on coding properties of bases, on possible errors of nucleic acid biosynthesis, and on configurations of nucleotide mispairs. The atomic structure of nucleic acid fragments with modified bases and the role of base damages in mutagenesis and carcinogenesis are considered.
authors.forename: V I
authors.initials: VI
authors.lastname: Poltev
authors.forename: V I
authors.initials: VI
authors.lastname: Bruskov
authors.forename: N V
authors.initials: NV
authors.lastname: Shuliupina
authors.forename: R
authors.initials: R
authors.lastname: Rein
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.forename: R
authors.initials: R
authors.lastname: Ornstein
authors.forename: J
authors.initials: J
authors.lastname: Miller
mesh_terms: D000478:Alkylation; D000586:Amination; D001483:Base Sequence; D004249:DNA Damage; D008969:Molecular Sequence Data; D009153:Mutagens / Q000737:chemistry*; D009696:Nucleic Acids / Q000096:biosynthesis / Q000737:chemistry*; D017382:Reactive Oxygen Species
chemical_list: D009153:Mutagens; D009696:Nucleic Acids; D017382:Reactive Oxygen Species
vernacular_title: Genotoksicheskaia modifikatsiia osnovaniĭ nukleinovykh kislot i ee biologicheskie posledstviia. Obzor i perspektivy éksperimental'nykh i raschetno-teoreticheskikh issledovaniĭ.