[Value of ketoconazole in the treatment of Cushing disease].
Ketoconazole has been successfully used in short-term treatment of Cushing's syndrome. We treated 4 patients who had Cushing's disease with ketoconazole administered during 5 to 18 months. Two of them are still controlled after 15 months of treatment and 7 months after treatment was withdrawn. In the other two patients, treatment was ineffective primarily and after 5 months. Our data confirm the usefulness of ketoconazole in the treatment of Cushing's disease, but they also show that primary resistance and tachyphylaxis in long-term treatment may occur, as previously reported.
Pascal
V
V
Clinique Médicale et Endocrinologique, Hôpital de Brabois, Vandoeuvre-les-Nancy.
Denet
S
S
Weryha
G
G
Kaminski
P
P
Leclère
J
J
Hartemann
P
P
D000328:Adult; D000368:Aged; D003480:Cushing Syndrome / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D007654:Ketoconazole
Intérêt du kétoconazole dans le traitement de la maladie de Cushing.