Antitumor activity of homo-aza-steroidal esters of p-N, N-bis(2-chloroethyl)aminophenoxyacetic acid.
The homo-aza-steroidal esters of carboxylic derivatives of N, N-bis (2-chloroethyl) aniline are reviewed. In particular, we discuss the antitumor activity of the esters of homo-aza steroids in which the p-N,N-bis(2-chloroethyl)aminophenoxyacetic acid is linked to the C-3 or C-17 position, while the lactam nucleus is linked to the D or A ring of the modified steroid respectively. The current literature indicates clearly that the potential of these esters is due to the synergistic activity of both the lactam and the p-N,N-bis(2-chloroethyl)aminophenoxyacetic acid.
Catsoulacos
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School of Health and Sciences, Department of Pharmacy, University of Patras, Greece.
Catsoulacos
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D
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001378:Azasteroids; D003110:Colonic Neoplasms / Q000188:drug therapy*; D006718:Homosteroids / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use*; D010642:Phenoxyacetates / Q000627:therapeutic use*; D013256:Steroids; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001378:Azasteroids; D006718:Homosteroids; D009588:Nitrogen Mustard Compounds; D010642:Phenoxyacetates; D013256:Steroids; C082605:4-N,N-bis(2-chloroethyl)aminophenoxyacetic acid; C100060:phenesterin