title: Exercise training decreases plasma cholesteryl ester transfer protein.
abstract: To assess the effect of exercise on the plasma concentration of cholesterol ester transfer protein (CETP) and its possible influence in mediating the exercise-associated redistribution of cholesterol among plasma lipoproteins, we measured plasma CETP in 57 healthy normolipidemic men and women before and after 9 to 12 months of exercise training. The training protocol resulted in significant changes in VO2max (mean +/- SD, +5.3 +/- 3.5 mL.kg-1 x min-1), body weight (-2.5 +/- 3.5 kg), plasma triglycerides (-25.7 +/- 36.3 mg/dL), high-density lipoprotein cholesterol (HDL-C) (+2.6 +/- 6.2 mg/dL), and ratios of total cholesterol to HDL-C (-0.30 +/- 0.52) and low-density lipoprotein cholesterol (LDL-C) to HDL-C (-0.18 +/- 0.45) (all P < or = .05) but no change in lipoprotein(a). CETP concentration (in milligrams per liter) fell significantly in response to training in both men (n = 28, 2.47 +/- 0.66 to 2.12 +/- 0.43; % delta = 14.2%; P < .005) and women (n = 29, 2.72 +/- 1.01 to 2.36 +/- 0.76; % delta = 13.2%; P < .047). The CETP change was observed both in subjects who lost weight (n = 28, delta mean weight = -5.0 kg; delta CETP = -0.42 +/- 0.79; % delta = 15.4%; P < .009) and in those who were weight stable (n = 29, delta mean weight = -0.12 kg; delta CETP = -0.29 +/- 0.78; % delta = 10.4%; P < .055).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110-1093.
authors.forename: R L
authors.initials: RL
authors.lastname: Seip
authors.forename: P
authors.initials: P
authors.lastname: Moulin
authors.forename: T
authors.initials: T
authors.lastname: Cocke
authors.forename: A
authors.initials: A
authors.lastname: Tall
authors.forename: W M
authors.initials: WM
authors.lastname: Kohrt
authors.forename: K
authors.initials: K
authors.lastname: Mankowitz
authors.forename: C F
authors.initials: CF
authors.lastname: Semenkovich
authors.forename: R
authors.initials: R
authors.lastname: Ostlund
authors.forename: G
authors.initials: G
authors.lastname: Schonfeld
mesh_terms: D000368:Aged; D002352:Carrier Proteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters / Q000378:metabolism*; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D015431:Weight Loss
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters; D006023:Glycoproteins; D008074:Lipoproteins; D002784:Cholesterol