Standardization of prothrombin times in newborn infants.
The prothrombin time (PT) for patients receiving warfarin varies widely, reflecting the heterogeneity of thromboplastin reagents. The International Committee on Thrombosis and Haemostasis recommends that PT values for these patients be expressed as international normalized ratios. This study showed that thromboplastin reagents also significantly influence PT values in neonatal plasma and that expressing PT values as international normalized ratios decreases this variability.
Pinto
M
M
Department of Paediatrics, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Mitchell
L
L
McCusker
P
P
Andrew
M
M
D000328:Adult; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007202:Indicators and Reagents; D007231:Infant, Newborn; D011517:Prothrombin Time; D012015:Reference Standards; D012680:Sensitivity and Specificity
D007202:Indicators and Reagents