title: Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor.
abstract: Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of alpha-tocopherol to alpha-tocopherol quinone.
authors.affiliation: Wellcome Research Laboratories, Beckenham, Kent, UK.
authors.forename: A
authors.initials: A
authors.lastname: Graham
authors.forename: N
authors.initials: N
authors.lastname: Hogg
authors.forename: B
authors.initials: B
authors.lastname: Kalyanaraman
authors.forename: V
authors.initials: V
authors.lastname: O'Leary
authors.forename: V
authors.initials: V
authors.lastname: Darley-Usmar
authors.forename: S
authors.initials: S
authors.lastname: Moncada
mesh_terms: D002460:Cell Line; D006801:Humans; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008565:Membrane Proteins; D009566:Nitrates / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011971:Receptors, Immunologic / Q000378:metabolism*; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D014810:Vitamin E / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D008565:Membrane Proteins; D009566:Nitrates; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D014810:Vitamin E; C039642:peroxynitric acid