title: ADP-ribosylation of neurofilaments by a cytoplasmic ADP-ribose transferase associated with free mRNP.
abstract: ADP-ribosylation of neurofilaments by an ADP-ribose transferase isolated from cytoplasmic ribonucleoprotein particles is demonstrated. The 150 kDa neurofilament subunit appears to be the main ADP-ribose acceptor with the transfer of ADP-ribose dimers or monomers. A binding of about 1 mole ADP-ribose per 8 moles of neurofilament subunits has been recorded. An interaction between neurofilaments' ADP-ribosylation and their phosphorylation state is demonstrated.
authors.affiliation: Centre de Neurochimie, C.N.R.S., Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Jesser
authors.forename: F
authors.initials: F
authors.lastname: Hog
authors.forename: C
authors.initials: C
authors.lastname: Chypre
authors.forename: J F
authors.initials: JF
authors.lastname: Leterrier
authors.forename: P
authors.initials: P
authors.lastname: Mandel
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000818:Animals; D015153:Blotting, Western; D002413:Cations, Divalent / Q000494:pharmacology; D002417:Cattle; D003600:Cytosol / Q000201:enzymology; D004591:Electrophoresis, Polyacrylamide Gel; D007382:Intermediate Filaments / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009243:NAD / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D051381:Rats; D012261:Ribonucleoproteins / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D002413:Cations, Divalent; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases