[Approach to the study of natural peptides from structure to functions. III. Structural organization of an adrenorphin molecule and its synthetic analogs].
Spatial structure of the peptide hormone adrenorphin was investigated by the theoretical conformational method. A solution of the "reverse conformational problem" for adrenorphin made it possible to predict a series of the modified synthetic analogues, which may assume one of the low-energy conformations of the native hormone.
Akhmedov
N A
NA
Makhmudova
T A
TA
Popov
E M
EM
D000595:Amino Acid Sequence; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D004744:Enkephalin, Methionine; C039700:adrenorphin
Podkhod k izucheniiu prirodnykh peptidov ot struktury k funktsii. III. Strukturnaia organizatsiia molekuly adrenorfina i ego iskusstvennykh analogov.