Effects of a new calcium antagonist, CD-832, on experimental coronary artery spasm in miniature pigs.
The effects of a new calcium antagonist, CD-832, on experimental coronary artery spasms were studied in Göttingen miniature pigs. Pigs underwent endothelial denudation at the left anterior descending coronary artery using a balloon catheter. Changes in the diameter of the denuded and nondenuded site in response to an intracoronary administration of serotonin (10 micrograms/kg) or histamine (10 micrograms/kg) were assessed quantitatively by selective coronary arteriography 1 week after endothelial denudation. Percent reductions of the coronary artery diameter induced by serotonin or histamine in the denuded site were significantly greater than those in the nondenuded site (p < 0.01). Coronary artery spasm induced by serotonin or histamine in the denuded site was attenuated in a dose-dependent manner by intravenous infusion of CD-832 (10 and 30 micrograms/kg/min) or nifedipine (1 and 3 micrograms/kg/min). The degrees of inhibition of coronary artery spasm by CD-832 were similar to those produced by nifedipine. CD-832 and nifedipine at the high dose caused comparable increases in the basal coronary artery diameter. These results suggest that CD-832 may be a useful drug for the treatment of coronary artery spasm.
Takahashi
T
T
Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Fukai
T
T
Hata
H
H
Kasuya
H
H
Kuga
T
T
Egashira
K
K
Takeshita
A
A
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000517:prevention & control*; D004195:Disease Models, Animal; D006632:Histamine; D007262:Infusions, Intravenous; D007650:Ketanserin / Q000627:therapeutic use; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011859:Radiography; D012701:Serotonin; D013552:Swine; D013556:Swine, Miniature
C082828:CD 832; D002121:Calcium Channel Blockers; D009536:Niacinamide; D012701:Serotonin; D006632:Histamine; D007650:Ketanserin; D009543:Nifedipine