Reduced incidence of stress ulcer in germ-free Sprague Dawley rats.
Recent findings with respect to the role of spiral gram-negative bacteria in peptic ulcer disease have stimulated interest in discerning the role of these agents in stress ulcer disease. We tested the hypothesis that a standard restraint-cold ulcerogenic procedure would fail to produce ulcers in axenic rats. Axenic, as well as normal Sprague Dawley rats, were exposed to a cold-restraint procedure. The germ-free condition was maintained throughout the study in the axenic rats. Axenic rats had significantly fewer ulcers as compared to normal rats exposed to the standard cold-restraint procedure, as well as handling control rats. The data represent the first report suggesting a microbiologic component in the development of stress ulcer using the rat model.
Paré
W P
WP
Department of Veterans Affairs Medical Center, Perry Point, MD 21902.
Burken
M I
MI
Allen
E D
ED
Kluczynski
J M
JM
D000704:Analysis of Variance; D000818:Animals; D005753:Gastric Mucosa / Q000382:microbiology; D005856:Germ-Free Life; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D015994:Incidence; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000382:microbiology* / Q000473:pathology / Q000523:psychology*; D013315:Stress, Psychological / Q000150:complications*