Effect of antihypertensive treatment on psychomotor performance in the elderly.
The psychomotor effects of control of hypertension were studied in a parallel group comparison of 25 elderly hypertensives (aged 61-79 years; SBP = 192 (range 162-212) mmHg; DBP = 112 (range 98-124) mmHg) shown to have psychomotor impairment when not on antihypertensive treatment. Single blind treatment was commenced with placebo or a diuretic: atenolol, nifedipine or captopril (5 x n = 5). A range of tests using an automated psychomotor test battery showed a significant improvement compared with placebo in tests of attention and psychomotor speed in subjects rendered normotensive (n = 18) after treatment for one week (SDST + 3.8, P < 0.001; CAT + 1.2, P < 0.03; PWAT + 1.9, P < 0.004; INSP -49.5 ms, P < 0.001). Subgroup analysis suggested greater improvement in psychomotor performance with captopril, but this was equivocal because of the small sample size in each group. Hence, the psychomotor effects of treatment with nifedipine and captopril were compared in a further 13 hypertensives (aged 62-76 years; SBP = 178 (range 169-193) mmHg; DBP = 106 (range 97-117) mmHg) in a double-blind crossover study. With both drugs, control of hypertension was associated with a significant and comparable improvement in several psychomotor performance measures. The results suggest that impaired psychomotor performance due to hypertension improves with antihypertensive treatment. The improvement appears to be related to control of hypertension rather than to the direct CNS effects of antihypertensive drugs.
Kalra
L
L
Department of Health Care of the Elderly, Kings College School of Medicine and Dentistry, London, UK.
Jackson
S H
SH
Swift
C G
CG
D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance / Q000502:physiology*; D016037:Single-Blind Method
D000959:Antihypertensive Agents