[Effect of immobilization of amidopyrine in polyvinyl alcohol on mutagenicity of yeast].
Frequency of gene mutations was studied on the yeast Saccharomyces cerevisiae after treatment with amidopyrine (AP) and polyvinyl alcohol (PVA). PVA was found to have no mutagenic activity, whereas AP increased mutation frequency in dependence of drug concentrations (15 and 30 mg/ml) and the duration of cell treatment (4 and 24 hours). Immobilization of AP in PVA led to decrease in drug mutagenicity.
Korzhenevskaia
M A
MA
Mikheev
V S
VS
D000632:Aminopyrine / Q000737:chemistry / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009154:Mutation; D011142:Polyvinyl Alcohol; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*
D000632:Aminopyrine; D011142:Polyvinyl Alcohol
Effekt immobilizatsii amidopirina v polivinilovom spirte na mutagennost' drozhzheĭ.