title: Involvement of prostaglandins in chilli-induced early gastric vascular damage in adult Wistar rat.
abstract: OBJECTIVE
  To explore the role of prostaglandins in protecting against chilli-induced early gastric vascular damage.
  
  
  METHODS
  Early gastric vascular damage was induced in rats by oral administration of 8 mg/Kg chilli extract. The damage was assessed by estimating spectrophotometrically the amount of Evan's blue leaking into gastric tissue and luminal contents 10 min after exposure to chilli. Further groups of rats were pretreated with misoprostol (10, 25 or 50 micrograms/Kg) or dazmegrel (1, 5 or 25 mg) to evaluate their protective effects.
  
  
  RESULTS
  Both misoprostol and dazmegrel were able to reduce gastric vascular damage induced by chilli in a dose-dependent fashion.
  
  
  CONCLUSIONS
  Prostaglandins may play a role in protecting against chilli-induced early gastric vascular damage.
authors.affiliation: Department of Pharmacology, Seth G S Medical College, Bombay.
authors.forename: U M
authors.initials: UM
authors.lastname: Thatte
authors.forename: N R
authors.initials: NR
authors.lastname: Pai
authors.forename: M A
authors.initials: MA
authors.lastname: Varade
authors.forename: P S
authors.initials: PS
authors.lastname: Anklesaria
authors.forename: S A
authors.initials: SA
authors.lastname: Dahanukar
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000009:adverse effects*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply; D005756:Gastritis / Q000209:etiology* / Q000517:prevention & control; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D016595:Misoprostol / Q000627:therapeutic use; D011292:Premedication; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
chemical_list: D007093:Imidazoles; D011453:Prostaglandins; D016595:Misoprostol; C039242:dazmegrel; D013930:Thromboxane-A Synthase; D002211:Capsaicin