Involvement of prostaglandins in chilli-induced early gastric vascular damage in adult Wistar rat.
OBJECTIVE
To explore the role of prostaglandins in protecting against chilli-induced early gastric vascular damage.


METHODS
Early gastric vascular damage was induced in rats by oral administration of 8 mg/Kg chilli extract. The damage was assessed by estimating spectrophotometrically the amount of Evan's blue leaking into gastric tissue and luminal contents 10 min after exposure to chilli. Further groups of rats were pretreated with misoprostol (10, 25 or 50 micrograms/Kg) or dazmegrel (1, 5 or 25 mg) to evaluate their protective effects.


RESULTS
Both misoprostol and dazmegrel were able to reduce gastric vascular damage induced by chilli in a dose-dependent fashion.


CONCLUSIONS
Prostaglandins may play a role in protecting against chilli-induced early gastric vascular damage.
Thatte
U M
UM
Department of Pharmacology, Seth G S Medical College, Bombay.
Pai
N R
NR
Varade
M A
MA
Anklesaria
P S
PS
Dahanukar
S A
SA
D000818:Animals; D002211:Capsaicin / Q000009:adverse effects*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply; D005756:Gastritis / Q000209:etiology* / Q000517:prevention & control; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D016595:Misoprostol / Q000627:therapeutic use; D011292:Premedication; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D007093:Imidazoles; D011453:Prostaglandins; D016595:Misoprostol; C039242:dazmegrel; D013930:Thromboxane-A Synthase; D002211:Capsaicin