Postnatal development of nonshivering thermogenesis in rats: effects of rearing temperature.
A comparative chronological study (from 1 to 33 days post partum) was performed to establish the capacity for nonshivering thermogenesis (NST) in rats born and reared at 28 degrees C and at 16 degrees C. The resting metabolism measured at 33 degrees C was higher in the 16 degrees C rats than in the 28 degrees C rats from the 3rd day. When expressed per weight or per surface area units it was higher in 16 degrees C pups than in 28 degrees C pups until the end of the 3rd week. In fact the resting metabolism was significantly proportional to different powers of weight (W0.67 at 16 degrees C and W0.75 at 28 degrees C) during the suckling period. At birth, respiratory quotient (RQ) was the same in both groups (0.70); it increased slowly to the end of the 3rd week (about 0.80). During the 3rd week RQ was lower in 16 degrees C rats than in 28 degrees C animals. This indicates that 16 degrees C rats are more dependent on the milk supplied by their mother. After weaning there were no differences in RQ values (0.90). Rectal temperature was low in both groups on day 1 (about 32 degrees C). It increased until weaning when it stabilized at 37 degrees C. From day 1 to day 18, it was significantly lower in cold reared rats. The capacity for NST was measured by investigating the effect of an injection of norepinephrine (NE) on the metabolic rate at 33 degrees C.(ABSTRACT TRUNCATED AT 250 WORDS)
Bertin
R
R
Laboratorie d'Adaptation Energétique à l'Environment, Ecole Pratique des Hautes Etudes, Paris, France.
De Marco
F
F
Mouroux
I
I
Portet
R
R
D000064:Acclimatization / Q000502:physiology; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001833:Body Temperature Regulation / Q000502:physiology*; D003080:Cold Temperature; D004298:Dopamine / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration; D013696:Temperature
D004298:Dopamine; D009638:Norepinephrine