Mechanism for splenocyte-mitogenesis induced in mice by water-extract of coniferous slash pine.
A water extract of wood chips of coniferous slash pine induced appreciable splenocyte-mitogenesis in healthy adult, aged, and also tumour-bearing mice. Mitogenesis was induced mainly in B-cell subset of splenocytes. The induction was not mediated by IL-2 or IFN gamma released from the activated helper T-cell. It may be worth noting that this extract could be included in a new type of immunomodulator for promotion of the host defense mechanism.
Kawazoe
T
T
2nd Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
Hongo
S
S
Takeda
M
M
Sato
T
T
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D003208:Concanavalin A; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D037102:Lectins; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D037121:Plant Lectins; D013154:Spleen / Q000187:drug effects / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D014197:Trees
D007376:Interleukin-2; D037102:Lectins; D008070:Lipopolysaccharides; D010936:Plant Extracts; D037121:Plant Lectins; D003208:Concanavalin A; D007371:Interferon-gamma; D013936:Thymidine