title: [A combination of immunostimulants as a method for correcting secondary immunodeficiencies].
abstract: The specific features of the action of combinations of immunostimulants (levamisole, prodigiozan, methyluracil) on a primary immune response to EB, GST and resistance to experimental infection have been studied. It has been shown that levamisole eliminates stimulation by methyluracil and prodigiozan of a primary immune response, lithium carbonate is also an antagonist of prodigiozan. Vitamin E increases the stimulating effect of prodigiozan rather than oxymethacil. The effect of vitamin A depends on the dose. Levamisole does not change the influence of prodigiozan and methyluracil on GST and, like prodigiozan, suppresses GST stimulated by lithium carbonate. The combination of prodigiozan and methyluracil to a large extent than the agent given alone increases resistance to an infection and efficiency of antibiotic therapy. The combination of methyluracil and levamisole increases only the effect of the antibiotic.
authors.forename: E K
authors.initials: EK
authors.lastname: Alekhin
authors.forename: D N
authors.initials: DN
authors.lastname: Lazareva
authors.forename: A Sh
authors.initials: ASh
authors.lastname: Bogdanova
authors.forename: L A
authors.initials: LA
authors.lastname: Riabchinskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Mufazalova
authors.forename: D D
authors.initials: DD
authors.lastname: Khasanova
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic
vernacular_title: Sochetanie immunostimuliatorov kak metod korrektsii vtorichnykh immunodefitsitov.