Expression of C-myc p62 oncoprotein in multiple myeloma: an immunohistochemical study of 180 cases.
The immunohistochemical expression of C-myc p62 oncoprotein was investigated using the immunoperoxidase method and the monoclonal antibody (Mab) MYC 1-9E10 in bone marrow paraffin sections. 180 cases of multiple myeloma (MM) were studied. C-myc expression was found to correlate well with the grade of malignancy, type of myeloma and tumor cell burden (p < 0.001). A relationship was also observed between C-myc p62 and IgA-secreting myelomas. It was found that intermediate grade myelomas are heterogeneous as far as C-myc expression is concerned. Our findings strongly suggest that C-myc might be involved in myelomutagenesis. The evaluation of its expression in MM may be helpful in determining the grade of malignancy and possibly the biological behaviour of this tumor.
Skopelitou
A
A
Pathology Department, University of Athens Medical School, Greece.
Hadjiyannakis
M
M
Tsenga
A
A
Theocharis
S
S
Alexopoulou
V
V
Kittas
C
C
Agnantis
N
N
D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000473:pathology*; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D015870:Gene Expression; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D009101:Multiple Myeloma / Q000378:metabolism* / Q000473:pathology*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*
D000911:Antibodies, Monoclonal; D016271:Proto-Oncogene Proteins c-myc