title: Elevated serum levels of IL-8 in patients with HIV infection.
abstract: Serum levels of IL-8 were determined in HIV-infected individuals and the results were compared with those for HIV- controls. The IL-8 levels were measured by an ELISA with a MoAb and a polyclonal antibody to recombinant IL-8. The means and 95% confidence intervals of IL-8 in sera of 36 HIV-infected individuals and 32 matched controls were 275 and 216-349 pg/ml, and 8 and 4-14 pg/ml, respectively, showing a 34-fold increase in IL-8 in the circulation of HIV-infected individuals. This increase does not appear to be related to the disease state, infection or systemic medical agents. This finding suggests the possible involvement of IL-8 in the pathogenesis of HIV-induced disease.
authors.affiliation: Department of Child Development, Kumamoto University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Miike
authors.forename: R P
authors.initials: RP
authors.lastname: Nelson
authors.forename: W L
authors.initials: WL
authors.lastname: Trudeau
authors.forename: R F
authors.initials: RF
authors.lastname: Lockey
authors.forename: J
authors.initials: J
authors.lastname: Yodoi
mesh_terms: D000328:Adult; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000097:blood* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D007375:Interleukin-1; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha