title: A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins.
abstract: We have previously used exon amplification to identify the ADD1 gene in cosmid Y24 from the Huntington's disease (HD) region of 4p16.3. The same technique has now yielded a second gene from this cosmid. This gene appears to encode a novel member of a superfamily of transporter proteins that includes active and passive transporters in a number of species. The predicted protein of 455 amino acids displays sequence similarity with the E. coli tetracycline resistance efflux protein encoded by cloning vector pBR322, and with a number of related transporters. This gene should open a route to isolating additional mammalian members of this growing superfamily.
authors.affiliation: Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston.
authors.forename: M P
authors.initials: MP
authors.lastname: Duyao
authors.forename: S A
authors.initials: SA
authors.lastname: Taylor
authors.forename: A J
authors.initials: AJ
authors.lastname: Buckler
authors.forename: C M
authors.initials: CM
authors.lastname: Ambrose
authors.forename: C
authors.initials: C
authors.lastname: Lin
authors.forename: N
authors.initials: N
authors.lastname: Groot
authors.forename: D
authors.initials: D
authors.lastname: Church
authors.forename: G
authors.initials: G
authors.lastname: Barnes
authors.forename: J J
authors.initials: JJ
authors.lastname: Wasmuth
authors.forename: D E
authors.initials: DE
authors.lastname: Housman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4; D004926:Escherichia coli / Q000235:genetics*; D005091:Exons; D015723:Gene Library; D005796:Genes; D005798:Genes, Bacterial; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D011323:Primates / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013753:Tetracycline Resistance / Q000235:genetics; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D026901:Membrane Transport Proteins; D012097:Repressor Proteins; D000099291:Adducins; C519998:MFSD10 protein, human; C034811:tetracycline resistance-encoding transposon repressor protein