title: Reproductive toxicity of vincristine in male rats.
abstract: Gross morphological and gravimetric changes were observed in the male reproductive system of sexually mature rats as well as rats in pubertal transition, given a continuous treatment of vincristine at dose levels of 10/20 and 5/10 micrograms respectively per day, for 15 days. The treatment resulted in a drastic regression of entire male reproductive system, suggesting that vincristine would cause male reproductive toxicity.
authors.affiliation: School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
authors.forename: A
authors.initials: A
authors.lastname: Stanley
authors.forename: H I
authors.initials: HI
authors.lastname: Averal
authors.forename: M A
authors.initials: MA
authors.lastname: Akbarsha
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014750:Vincristine / Q000633:toxicity*
chemical_list: D014750:Vincristine