title: Effect of in vivo He-Ne laser irradiation on biogenic amine levels in rat brain.
abstract: In order to elucidate the metabolic modifications induced in rat brain by low power He-Ne laser irradiation in vivo, the variations in the biogenic amine levels in cortex, striatum and hippocampus were studied. Noradrenaline (NA), dopamine (DA) and serotonin (5-HT) were evaluated by HPLC-EC on irradiated rats, untreated rats (controls) and rats which had undergone restraint stress (stressed). The results obtained on groups of four to eight rats assayed individually showed that irradiation caused a strong increase in 5-HT in striatum and hippocampus, a small but significant decrease in NA in cortex, and DA levels were not significantly affected. Restraint stress per se led to a considerable decrease in 5-HT and DA in striatum and hippocampus, but did not significantly alter the NA levels.
authors.affiliation: Istituto di Farmacologia e Farmacognosia, Facoltà di Farmacia, Università di Torin, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Cassone
authors.forename: A
authors.initials: A
authors.lastname: Lombard
authors.forename: V
authors.initials: V
authors.lastname: Rossetti
authors.forename: R
authors.initials: R
authors.lastname: Urciuoli
authors.forename: P M
authors.initials: PM
authors.lastname: Rolfo
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D002540:Cerebral Cortex / Q000378:metabolism / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism / Q000528:radiation effects; D004298:Dopamine / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000528:radiation effects; D007834:Lasers; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012149:Restraint, Physical; D012701:Serotonin / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D001679:Biogenic Amines; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine