Reproducibility of resting cerebral blood flow measurements with H2(15)O positron emission tomography in humans.
Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H2(15)O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean +/- SD) for the first (40.3 +/- 6.4) and second (39.3 +/- 6.5) measurements was not significantly different (mean % difference 2.3 +/- 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.
Matthew
E
E
Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Andreason
P
P
Carson
R E
RE
Herscovitch
P
P
Pettigrew
K
K
Cohen
R
R
King
C
C
Johanson
C E
CE
Paul
S M
SM
D000328:Adult; D000339:Affect; D002560:Cerebrovascular Circulation; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D010104:Oxygen Radioisotopes; D012016:Reference Values; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D012146:Rest; D014055:Tomography, Emission-Computed; D014867:Water
D010104:Oxygen Radioisotopes; D014867:Water