title: Should nonsteroidal anti-inflammatory drugs be used to treat osteoarthritis?
abstract: Millions of individuals with osteoarthritis have experienced relief of joint pain and improvement in mobility as a result of taking nonsteroidal anti-inflammatory drugs (NSAIDs). These agents are currently considered the drug of choice for treatment of osteoarthritis (OA). Despite their efficacy and nearly universal use in OA, the role of NSAIDs in managing this disorder recently has become controversial. This article reviews the issues that lie at the heart of the problem.
authors.affiliation: Rheumatology Division, Indiana University School of Medicine, Indianapolis.
authors.forename: K D
authors.initials: KD
authors.lastname: Brandt
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D002358:Cartilage, Articular / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007596:Joints / Q000503:physiopathology; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D010146:Pain
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal