title: Nuclear organization of pre-mRNA processing.
abstract: Recent studies have suggested that small nuclear ribonucleoprotein particles (snRNPs), non-snRNP splicing factors, and several heterogeneous nuclear RNP proteins change their organization within the cell in response to transcriptional activity. Several of the RNA substrates with which these factors interact have been shown to localize in tracks that are associated with regions in which splicing factors are concentrated (nuclear speckles). It is now thought that pre-mRNA splicing may occur within these tracks.
authors.affiliation: Cold Spring Harbor Laboratory, New York.
authors.forename: D L
authors.initials: DL
authors.lastname: Spector
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012261:Ribonucleoproteins / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012322:RNA Precursors; D012261:Ribonucleoproteins; D012319:RNA Polymerase II