Selective IgM deficiency in a patient with Hashimoto's disease.
A 70-year-old man with Hashimoto's disease had selective IgM deficiency, while other immunoglobulin levels were normal. In vitro mixing experiments were carried out in which B cells and T cells from the patient and from a healthy control donor were co-cultured in the presence of pokeweed mitogen, in order to investigate the etiology of IgM hypoproduction. The results indicated that the patient had B-cell dysfunction, involving the impairment of B-cell differentiation. In addition, both IgG of the healthy control donor and thyroid hormone may play important roles in the pathogenesis of this case.
Kimura
S
S
Department of Internal Medicine, Nishijin Hospital, Kyoto, Japan.
Tanigawa
M
M
Nakahashi
Y
Y
Inoue
M
M
Yamamura
Y
Y
Kato
H
H
Sugino
S
S
Kondo
M
M
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000172:deficiency*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology*
D007075:Immunoglobulin M