title: The effect of fluoride application on fluoride release and the antibacterial action of glass ionomers.
abstract: The aim of this study was to investigate whether the release of fluoride and the antimicrobial effect of freshly mixed glass ionomers could be prolonged by application of fluoride on aged material. Test slabs of freshly mixed and aged (14 d in water) conventional and silver glass ionomer (Ketac-Fil and Ketac-Silver, Espe, Seefeld, Germany) and composite (Silux Plus, 3M, St. Paul, MN) were fitted into the bottom of a test tube. A layer of S. mutans Ingbritt cells was centrifuged onto the test slabs, and the samples were incubated for 20 h in 1.7% sucrose solution. After the incubation, pH, F, and Ca contents of the fluid phase, and F, Mg, P, and K contents of the cells were determined. The aged glass-ionomer samples were then covered with toothpaste (0.1% F) or with fluoride gel (1.25% F), and the composite samples with fluoride gel. After being thoroughly rinsed, S. mutans cells were incubated on the samples as above. The pH fall was significantly inhibited by freshly mixed glass ionomers, and there were changes in cellular cation and phosphorus contents. Large amounts of fluoride were found in the fluid and cells. For old glass ionomers, no inhibitory effect on pH fall could be seen. Fluoride release had decreased to a low level.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Faculty of Dentistry, University of Kuopio, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Seppä
authors.forename: H
authors.initials: H
authors.lastname: Forss
authors.forename: B
authors.initials: B
authors.lastname: Ogaard
mesh_terms: D000704:Analysis of Variance; D017438:Bisphenol A-Glycidyl Methacrylate / Q000494:pharmacology; D016722:Cermet Cements / Q000494:pharmacology; D005460:Fluorides, Topical / Q000737:chemistry* / Q000494:pharmacology; D005782:Gels; D005899:Glass Ionomer Cements / Q000737:chemistry / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008298:Maleates / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects*; D013678:Technology, Pharmaceutical; D013997:Time Factors
chemical_list: D016722:Cermet Cements; D005460:Fluorides, Topical; D005782:Gels; D005899:Glass Ionomer Cements; D008298:Maleates; D017438:Bisphenol A-Glycidyl Methacrylate; C040964:Ketac-Fil