Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.
The sequence pattern CxxCxnGxCxxxGxmGCPP, thus far found in the small subunits from 21 different nickel hydrogenases, appears also to be present in the PSST polypeptide from NADH:ubiquinone oxidoreductase (Complex I) of beef-heart mitochondria. There is only one difference: the first cysteine residue is a leucine in the PSST subunit. The large nickel-binding subunit of nickel hydrogenases shows a surprising homology with the 49 kDa subunit of mitochondrial Complex I.
Albracht
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E.C. Slater Institute, BioCentrum, University of Amsterdam, The Netherlands.
D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D002417:Cattle; D008929:Mitochondria, Heart / Q000201:enzymology*; D008969:Molecular Sequence Data; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry
D009532:Nickel; D016660:NAD(P)H Dehydrogenase (Quinone)