title: Measurement of absolute blood iodine concentration during digital subtraction ventriculography.
abstract: A system to measure the absolute iodine concentration (mg iodine/milliliter blood) in the left ventricle (LV) during digital subtraction ventriculography has been developed. The technique uses a catheter to draw blood from the LV through a detection cell. This occurs as the iodine bolus passes through the heart. The cell determines iodine concentration by measuring x-ray attenuation as the iodinated blood passes between a low-power x-ray tube and a diode detector. In vitro and in vivo testing of the system was conducted. The system response was linear (r = 0.99) with respect to iodine concentration. This response was independent of hematocrit. Dispersion of contrast medium in the catheter caused distortion of the shape of the time-concentration curve. The impulse response of the system was measured and found to be independent of hematocrit. A correction algorithm based on Wiener filter deconvolution was developed. In vitro testing using simulated time-concentration curves demonstrated that the rms error in the iodine measurement after dispersion correction did not exceed 4% over the region of the time-concentration curve extending from the peak to the point on the tail where the signal fell to 50% of its peak value. Cardiac output was measured from the time-concentration curve via the indicator-dilution method in an animal model. This cardiac output measurement (COI) agreed closely with cardiac output measured simultaneously with an aortic flow probe (CO(P)), namely, COI = 1.02 CO(P)-0.03 L/min, r = 0.95, SEE = 10%, p < 0.001.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of Wisconsin School of Medicine, Madison 53792.
authors.forename: T P
authors.initials: TP
authors.lastname: Fuerst
authors.forename: M S
authors.initials: MS
authors.lastname: Van Lysel
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000502:physiology*; D004285:Dogs; D006801:Humans; D007455:Iodine / Q000097:blood*; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D007455:Iodine