title: Solid phase radionuclide esophageal motility in polymyositis and dermatomyositis.
abstract: Polymyositis (PM) and dermatomyositis (DM) may be associated with motor dysfunction of the entire gastrointestinal tract. Abnormal esophageal motor function is a well-recognized complication of these diseases. In this study, we used a solid phase esophageal study to evaluate the motor function in patients with PM or DM. Twenty-three patients and 36 age-matched normal volunteers were studied. Each subject was placed in a supine position above a gamma camera linked to a computer and was given a 4-ml bolus of solid gelatin containing 1 mCi of Tc-99m phytate. Data were acquired in the list mode. A computer method modified from Kelim and Wald and Russell et al. was used to calculate the following: A) total mean transit time (MTT); B) residual fraction after the first swallow (RF); and C) retrograde index (RI). All values are presented as mean +/- standard deviation (SD). The Student's t-test was used to test statistical significance. Our preliminary results suggest: 1) delayed esophageal emptying is common (17/23) in PM/DM, indicating frequent malfunction of the smooth muscle of the upper gastrointestinal tract in PM/DM and 2) measurement of esophageal motility may monitor disease activity in PM/DM.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: C P
authors.initials: CP
authors.lastname: Chang
authors.forename: J L
authors.initials: JL
authors.lastname: Lan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003882:Dermatomyositis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015154:Esophageal Motility Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004947:Esophagus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D017285:Polymyositis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging
chemical_list: D015609:Organotechnetium Compounds; C026177:technetium phytate; D010833:Phytic Acid