title: Spontaneous resolution of acquired factor X deficiency in amyloidosis.
abstract: We describe the case of a 51-year-old man with systemic amyloidosis in whom factor X activity was initially 6% of the normal. Amyloidosis was responsible for congestive heart failure and a nephrotic syndrome but there was no bleeding diathesis. A 12-month trial of melphalan and prednisone failed to improve cardiac and renal dysfunction; factor X levels remained low. Eighteen months after this treatment was stopped, factor X spontaneously normalized although renal insufficiency persisted. We suggest that the possibility of a spontaneous factor X recovery must be considered when evaluating efficacy of therapeutic agents in amyloidosis.
authors.affiliation: Department of Internal Medicine A, Saint-Eloi Hospital, Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: le Quellec
authors.forename: A
authors.initials: A
authors.lastname: Sotto
authors.forename: A J
authors.initials: AJ
authors.lastname: Ciurana
mesh_terms: D000686:Amyloidosis / Q000150:complications*; D005171:Factor X Deficiency / Q000097:blood* / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous