[Effects of selenium on the glycolysis and gluconeogenesis system in rat liver].
We studied the effect of selenium on the glycolysis and gluconeogenesis system in the rat liver. Significant decreases in glucose level in the serum were observed from the 4th day after daily intraperitoneal (i.p.) administration of selenite (173 micrograms/kg, 78.9 micrograms/kg of selenium base equivalent). Selenium was also effective in reducing a precursor of gluconeogenesis, lactate, alanine or glycerol, in the serum. Moreover, there were significant decreases in the activities of pyruvate carboxylase and glucose-6-phosphatase, a rate-limiting enzyme of gluconeogenesis, in the liver of selenium-treated rates. On the contrary, the activities of glycokinase and phosphofructokinase, a rate-limiting enzyme of glycolysis, in the liver of rat treated with selenium significantly increased in comparison with the control group. These data, therefore, indicated that the hypoglycemic effect of selenium might be due to the acceleration of glucose metabolism and the inhibition of glucose synthesis in the liver, suggesting a decrease in a source of precursor supply for the gluconeogenesis.
Iizuka
Y
Y
Tohoku College of Pharmacy, Sendai, Japan.
Sakurai
E
E
Maeda
K
K
Hikichi
N
N
D000409:Alanine / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D005943:Gluconeogenesis / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects*; D007773:Lactates / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D010732:Phosphofructokinase-1 / Q000097:blood; D011766:Pyruvate Carboxylase / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*
D001786:Blood Glucose; D007773:Lactates; D010732:Phosphofructokinase-1; D011766:Pyruvate Carboxylase; D012643:Selenium; D000409:Alanine