title: Decrease in vivo of cysteine endopeptidases in blood of patients with tumor of the larynx.
abstract: Since cysteine endopeptidase (cathepsins B and L) have been proposed to be implicated in tumor malignancy, we have attempted to decrease these in vivo. Large amounts of urine cysteine peptidase inhibitors (UCPI) are present in the urine of patients. Our results indicate protective effects of a UCIP preparation against human serum cysteine endopeptidases.
authors.affiliation: ENT Department of Regional Hospital, Wroclaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Mikulewicz
authors.forename: I
authors.initials: I
authors.lastname: Berdowska
authors.forename: J
authors.initials: J
authors.lastname: Jarmułowicz
authors.forename: M
authors.initials: M
authors.lastname: Siewiński
mesh_terms: D000328:Adult; D002846:Chromatography, Affinity; D003546:Cysteine Endopeptidases / Q000097:blood* / Q000652:urine; D015853:Cysteine Proteinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000652:urine; D008297:Male
chemical_list: D015853:Cysteine Proteinase Inhibitors; D003546:Cysteine Endopeptidases