Nitric oxide activates buccal motor patterns in Lymnaea stagnalis.
The mollusc, Lymnaea stagnalis, has been used as a model to study the mechanisms of nitric oxide (NO)-dependent processes in the CNS. Putative NO-containing neurones in Lymnaea are localized in the buccal ganglia, predominantly in areas where sensory neurones known to regulate feeding are found. The NO-generating substance, S-nitrosocysteine (S-NC, 5 x 10(-5)-10(-3 M) activates feeding movements of the buccal mass and modulates the activity of buccal motoneurones. An inhibitor of NO synthase, NG-methyl-L-arginine (10(-4) M) decreases the frequency of background buccal movements and has opposite effects to S-NC on the buccal motoneurones. We suggest that NO is a messenger in the CNS of Lymnaea and may be involved in coordination of feeding motor patterns.
Moroz
L L
LL
Department of Physiology, University of Leeds, UK.
Park
J H
JH
Winlow
W
W
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D008058:Dihydrolipoamide Dehydrogenase / Q000032:analysis; D005247:Feeding Behavior / Q000187:drug effects; D005724:Ganglia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006651:Histocytochemistry; D008195:Lymnaea / Q000502:physiology*; D009046:Motor Neurons / Q000187:drug effects; D009068:Movement / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology*; D019335:Nitroarginine; D026403:S-Nitrosothiols
D026403:S-Nitrosothiols; D019335:Nitroarginine; D009569:Nitric Oxide; C021315:S-nitrosocysteine; D001120:Arginine; D008058:Dihydrolipoamide Dehydrogenase; D003545:Cysteine