Sneddon's syndrome and phospholipid antibodies.
We present a case of Sneddon's syndrome with high titers of antiphospholipid antibodies (APLA), in which the leading symptom was an incapacitating memory defect. MRI revealed vasculitic lesions of the central nervous system (CNS). Therefore immunosuppressive therapy was started with steroids and cyclophosphamide pulses. The transient beneficial effects of such a therapy will be discussed.
Mesa
H A
HA
Department of Rheumatology and Clinical Immunology, University of Freiburg Medical Center, Freiburg, Germany.
Lang
B
B
Schumacher
M
M
Vaith
P
P
Peter
H H
HH
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000209:etiology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000209:etiology; D017445:Skin Diseases, Vascular / Q000150:complications / Q000276:immunology* / Q000523:psychology; D013577:Syndrome
D017152:Antibodies, Antiphospholipid; D003520:Cyclophosphamide