[Thrombolytic effect of plasmin, miniplasmin and fibrinolysin in simulated intraocular hemorrhage].
The fibrinolytic properties of the preparations of plasmin (Pm), mixture of plasminogen and streptokinase (Pg+Sk), miniplasmin (m-Pm) and fibrinolysin have been investigated on the models of rabbit's hyphema. The action of preparations of Pm and Pg+Sk had approximately equal therapeutic index--the total destruction of clots proceeded for 12.0 days, that was 6.6 days less than in the control group. The therapeutic effect for m-Pm was 3.6 days. The dose of preparation of m-Pm, necessary for total destruction of clots, was 15-20% greater than for the same dose of Pg+Sk. The preparation of fibrinolysin, used in the same quantities of proteolytic activity, as Pg and m-Pg, (16 caseinolytic units per 1 injection) had no therapeutic effect.
Metelitsyna
I P
IP
Petretskaia
O S
OS
Rodin
S S
SS
Andrianov
S I
SI
D000818:Animals; D004195:Disease Models, Animal; D005341:Fibrinolysin / Q000627:therapeutic use*; D006988:Hyphema / Q000188:drug therapy*; D010446:Peptide Fragments / Q000627:therapeutic use*; D011817:Rabbits
D010446:Peptide Fragments; C019493:miniplasmin; D005341:Fibrinolysin
Tromboliticheskoe deĭstvie plazmina, miniplazmina i fibrinolizina v usloviiakh modelirovaniia vnutriglaznogo krovoizliianiia.