Immunothermotherapy and related TNS induction in mice.
Induction of tumor necrosis factor in sera (TNS) as a multidisciplinary cancer therapy by the administration of a combination of 2-carboxyethylgermanium sesquioxide (Ge-132) and lipopolysaccharide (LPS) on Meth-A sarcoma-bearing mice was attempted. In addition to the above TNS induction therapy (TNS therapy) per se, the potential on the above parameters by employing a multidisciplinary cancer therapy (immunothermotherapy), in which TNS therapy was coupled with regional hyperthermia treatment, was investigated. This immunothermotherapy enhanced the antitumor effects produced by the above TNS therapy.
Kuwabara
M
M
Department of Veterinary Radiology, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005857:Germanium / Q000627:therapeutic use*; D006979:Hyperthermia, Induced; D007167:Immunotherapy; D008070:Lipopolysaccharides / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011422:Propionates; D012513:Sarcoma, Experimental / Q000097:blood / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000970:Antineoplastic Agents; D008070:Lipopolysaccharides; D009942:Organometallic Compounds; D011422:Propionates; D014409:Tumor Necrosis Factor-alpha; D005857:Germanium; C066750:propagermanium