Hemodialysis and iopamidol clearance after subclavian venography.
OBJECTIVE
The dialyzability of iopamidol is unknown and was investigated in patients undergoing long-term hemodialysis for chronic renal failure.


METHODS
Ten patients received 30 ml Niopam 300 (Bracco SpA, Milan, Italy) (identical to 18372 mg iopamidol) intravenously into a forearm vein to investigate for occult subclavian stenosis.


RESULTS
The elimination half-life of iopamidol before hemodialysis was 69.6 hours and during 4 hours of hemodialysis was 3.5 hours. A single 4-hour hemodialysis cleared 55.7% (95% Ci 51-5-59.8) of the administered dose, while second and third dialyses cleared 25.3% (95% Ci 21.4-29.1) and 10.1% (95% Ci 7.7-12.6) of the administered dose, respectively. Two patients with significant residual urine excretion excreted more than 10% of the administered dose in the urine. For anuric patients, extrarenal clearance provided total body clearance of up to 0.266 L/hr.


CONCLUSIONS
Hemodialysis is a rapid and efficient means of clearing iopamidol provided it is performed soon after the contrast study.
Donnelly
P K
PK
Department of Surgery, Leicester University, England.
Burwell
N
N
McBurney
A
A
Ward
J W
JW
Walls
J
J
Watkin
E M
EM
D000328:Adult; D000368:Aged; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007479:Iopamidol / Q000008:administration & dosage / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013350:Subclavian Vein
D007479:Iopamidol