title: Emulsification and fatty-acid chain length affect the utilization of medium-chain triglycerides by neonatal pigs.
abstract: Three experiments were conducted using 52 pigs between 22 and 35 h of birth to determine the effects of emulsification and fatty-acid chain length on utilization of medium-chain triglycerides (MCT). After a 4-h period during which feed was withheld, pigs were force-fed 6 mL of nonemulsified (NE) MCT or 20 mL of a 30% (vol/vol) Tween 80-(polyoxy-ethylene [20] sorbitan monooleate) MCT emulsion, marking time 0, and serial blood samples were drawn throughout 8 h for analysis of medium-chain fatty acid (MCFA) concentrations by HPLC. In Exp. 1, pigs received either NE or emulsified Tri-C4, -C5, -C6, or -C7. The emulsified treatments were discontinued due to deaths caused by coma resulting from high concentrations (up to 12 mM) of plasma MCFA. Concentrations in pigs fed emulsified MCT were 2.5-fold higher than those in pigs fed NE MCT. In pigs fed NE MCT, concentrations of even-chain-length MCFA were higher than those of odd-chain-length MCFA (P < .001), with a tendency for C6 to be higher than C4 (P < .1). In Exp. 2 and 3, pigs received an equimolar mixture of MCT in either emulsified or NE form. In Exp. 2, the mixture contained Tri-C4 through Tri-C7; whereas, in Exp. 3 the mixture contained Tri-C4, -C6, -C8, and -C10. A three-way interaction (emulsion x fatty acid x sample time; P < .05) was observed in both experiments.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Animal Sciences, University of Illinois, Urbana 61801.
authors.forename: T M
authors.initials: TM
authors.lastname: Wieland
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.forename: J
authors.initials: J
authors.lastname: Odle
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D003128:Coma / Q000139:chemically induced / Q000662:veterinary; D004063:Digestion; D004655:Emulsions; D005227:Fatty Acids / Q000097:blood / Q000737:chemistry*; D007408:Intestinal Absorption; D011136:Polysorbates; D011897:Random Allocation; D013552:Swine / Q000378:metabolism*; D013553:Swine Diseases / Q000139:chemically induced; D014280:Triglycerides / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D004655:Emulsions; D005227:Fatty Acids; D011136:Polysorbates; D014280:Triglycerides