Apomorphine induced hypothermia, stereotypy and changes in dopamine D2 mRNA expression.
The changes in DA-D2 receptor mRNA expression following apomorphine induced hypothermia and stereotypy were determined. Rectal temperatures and stereotypy were measured daily after apomorphine injection to Sprague-Dawley rats for 7 days. DA-D2 mRNA expression was determined by Northern blot analysis. Apomorphine caused a dose dependent decrease and increase in rectal temperatures and stereotypy respectively. Northern blot analysis indicated a relative abundance of the DA-D2 receptor message at the high and a reduction at the lower dose of apomorphine. The result showed that the agonist activity could influence the expression of DA-D2 receptor mRNA.
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Department of Pharmacology, Meharry Medical College, Nashville, TN 37208.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D015152:Blotting, Northern; D001831:Body Temperature / Q000187:drug effects*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis* / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D001058:Apomorphine