title: Antigen-presenting cell types.
abstract: Different antigen-presenting cells elicit responses in different T-cell populations for primary activation, secondary stimulation and cytotoxic effector functions. Maturing bone marrow derived dendritic cells may acquire and process antigens, transport them to lymph nodes and activate naive T cells located there. By contrast, follicular dendritic cells, acquiring antigen-antibody complexes, maintain 'memory' via B-cell activation. Effector memory T cells recognize various tissue cells bearing antigen and we speculate that they may also target specialized antigen-presenting dendritic populations.
authors.affiliation: Clinical Research Centre, Harrow, Middlesex, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Knight
authors.forename: A J
authors.initials: AJ
authors.lastname: Stagg
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D001854:Bone Marrow Cells; D002465:Cell Movement; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D006681:HLA-D Antigens / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D051381:Rats; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000941:Antigens; D015703:Antigens, CD; D006681:HLA-D Antigens; D015395:Histocompatibility Antigens Class I