title: Early stage of development in testicular choriocarcinomas.
abstract: Choriocarcinoma is the most malignant among germ cell tumors in the testis. However little is known about the early stage of its development. To understand the development of testicular choriocarcinomas, twenty cases of testicular choriocarcinoma were studied histologically and immunohistochemically. It was found that in the early stage of development, choriocarcinomas imitate the morphologic or functional differentiation of normal trophoblasts. It was also found that some choriocarcinomas regress spontaneously in the early stage. The majority of choriocarcinomas seemed to develop by first going through the embryonal carcinoma phase. However, there were some choriocarcinomas that showed no relationship with embryonal carcinoma.
authors.affiliation: Department of Pathology, Niigata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Motoyama
authors.forename: N
authors.initials: N
authors.lastname: Sasano
authors.forename: S
authors.initials: S
authors.lastname: Yonezawa
authors.forename: O
authors.initials: O
authors.lastname: Matsuzaki
authors.forename: A
authors.initials: A
authors.lastname: Kawaoi
authors.forename: Y
authors.initials: Y
authors.lastname: Kamata
authors.forename: S
authors.initials: S
authors.lastname: Sasou
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.forename: R
authors.initials: R
authors.lastname: Takanashi
authors.forename: T
authors.initials: T
authors.lastname: Sano
mesh_terms: D002822:Choriocarcinoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D013736:Testicular Neoplasms / Q000473:pathology*; D013997:Time Factors