Azidothymidine (AZT)-induced siderosis.
Azidothymidine (AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT-treated mice.
Pollack
S
S
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
Weaver
J
J
D000818:Animals; D004195:Disease Models, Animal; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism; D006418:Heme / Q000032:analysis; D007501:Iron / Q000032:analysis; D008099:Liver / Q000737:chemistry; D008264:Macrophages / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D012806:Siderosis / Q000209:etiology*; D015215:Zidovudine / Q000009:adverse effects*
D006418:Heme; D015215:Zidovudine; D007501:Iron