[Elevation of serum apo E-rich HDL concentration in a patient with cholestatic liver disease].
A remarkable elevation of serum HDL cholesterol concentration (165mg/dl) was found in a 42-year-old Japanese male with chronic pancreatitis who had been cholestatic for several years. An abnormal slow alpha-migrating lipoprotein, larger in particle size and more enriched with cholesteryl ester and apo E than normal HDL, was found in the patient's plasma. Quantitative determination of apo E-rich HDL revealed a striking increase of this lipoprotein in plasma. After choledocho-jejunostomy, a prompt and remarkable decrease of plasma apo E-rich HDL was observed, indicating a direct contribution of cholestasis to the accumulation of apo E-rich HDL in plasma in this patient.
Umemori
Y
Y
Clinical Laboratories, Asahikawa Medical College Hospital.
Chiba
H
H
Moriyama
T
T
Takeda
S
S
Hosokawa
H
H
Nobuoka
M
M
Makino
M
M
Eto
M
M
Akiyama
K
K
D000328:Adult; D001057:Apolipoproteins E / Q000097:blood*; D001651:Cholestasis, Extrahepatic / Q000097:blood*; D003137:Common Bile Duct Diseases / Q000097:blood*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008107:Liver Diseases / Q000097:blood; D008297:Male
D001057:Apolipoproteins E; D008075:Lipoproteins, HDL