Critical examination of an enzyme immunoassay for detection of positive IgM antibodies against toxoplasma in newborns.
The Toxonostika IgM test, which has been examined in this study, is a modified antibody capture test (7). Evaluation with sera from newborns revealed that, like in the ELISA tested in 1988, doubtful or false positive results were obtained in 10% of the cases (6). Therefore, a positive toxoplasmosis IgM result in newborn sera should always be retested with another test system.
Dohr
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Institut für Medizinische Mikrobiologie, Westfälischen Wilhelms-Universität Münster, Germany.
Oehme
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D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis* / Q000276:immunology; D007231:Infant, Newborn; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000175:diagnosis*
D000913:Antibodies, Protozoan; D007075:Immunoglobulin M