Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties.
Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.
Kato
S
S
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Shindo
K
K
Kawai
H
H
Odagawa
A
A
Matsuoka
M
M
Mochizuki
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005285:Fermentation; D000860:Hypoxia / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013302:Streptomyces / Q000737:chemistry*
D011758:Pyrroles; C082418:pyrrolostatin; D011392:Proline