title: Clear cell odontogenic carcinoma with lymph node metastasis.
abstract: Clear cell odontogenic tumors are rare. Review of the literature showed 9 cases with a prominent clear cell component. These lesions have exhibited an aggressive behavior characterized by an infiltrative local growth pattern, recurrence, or metastases. We report a case of an odontogenic tumor that exhibited a biphasic pattern and was characterized by lymph node involvement identical histologically to the primary tumor. We conclude that the presence of a clear cell component in an ameloblastomatous tumor should be viewed as a sign of de-differentiation, and that a malignancy with or without metastases should be considered and ruled out in such cases.
authors.affiliation: University of Medicine and Dentistry of New Jersey and University Hospital, Newark.
authors.forename: M
authors.initials: M
authors.lastname: Milles
authors.forename: J L
authors.initials: JL
authors.lastname: Doyle
authors.forename: M
authors.initials: M
authors.lastname: Mesa
authors.forename: S
authors.initials: S
authors.lastname: Raz
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008441:Maxillary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009808:Odontogenic Tumors / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed