title: Hypothalamic modulation of Purkinje cell activity in the anterior cerebellar vermis.
abstract: Intricate anatomical connections exist between the cerebellar vermis and the hypothalamus. This study examined the effects of electrical microstimulation of the hypothalamus on Purkinje cell activity in the anterior cerebellar vermis (ACV) in the awake rabbit. Single-pulse stimulation of the hypothalamus evoked robust, short-latency modifications of Purkinje cell discharge. Heterogeneous response profiles were observed with cells demonstrating patterns of either unimodal excitation, biphasic excitation/inhibition or complex triphasic responses. These results support the hypothesis that the hypothalamus and ACV are functionally interactive, and may promote further understanding of the role of the ACV in emotional behavior and autonomic responses.
authors.affiliation: Department of Psychology, University of Vermont, Burlington 05405-0134.
authors.forename: W F
authors.initials: WF
authors.lastname: Supple
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D004594:Electrophysiology; D007031:Hypothalamus / Q000502:physiology*; D008839:Microelectrodes; D011689:Purkinje Cells / Q000502:physiology*; D011817:Rabbits