title: Application of multiple modelling to hyperthermia estimation: reducing the effects of model mismatch.
abstract: Multiple model estimation is a viable technique for dealing with the spatial perfusion model mismatch associated with hyperthermia dosimetry. Using multiple models, spatial discrimination can be obtained without increasing the number of unknown perfusion zones. Two multiple model estimators based on the extended Kalman filter (EKF) are designed and compared with two EKFs based on single models having greater perfusion zone segmentation. Results given here indicate that multiple modelling is advantageous when the number of thermal sensors is insufficient for convergence of single model estimators having greater perfusion zone segmentation. In situations where sufficient measured outputs exist for greater unknown perfusion parameter estimation, the multiple model estimators and the single model estimators yield equivalent results.
authors.affiliation: Electrical and Computer Engineering Department, University of Arizona, Tucson 86721.
authors.forename: J K
authors.initials: JK
authors.lastname: Potocki
authors.forename: H S
authors.initials: HS
authors.lastname: Tharp
mesh_terms: D001831:Body Temperature; D003198:Computer Simulation; D005069:Evaluation Studies as Topic; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods / Q000706:statistics & numerical data; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy