The carbamate insecticide ZZ-Aphox induced structural changes of gills, liver, gall-bladder, heart, and notochord of Rana perezi tadpoles.
Embryos of Rana perezi were kept under laboratory conditions and treated with carbamate ZZ-Aphox at chronic doses of 0.02% and 0.14% for 9 weeks. Both the histological study and the analysis of mortality show a direct relationship between the dosage and the effects of the pesticide. The histological study of the survivors over 56 days show damages in gills, liver, gall-bladder, heart, and notochord. Damages on the epithelial of gills (on their distal portion) and gall-bladder recover over a few days, whereas those provoked on the compacting of the hepatic parenchyma and the hepatocytes, the auricle and the perintocohordal collagenic fibers alter their structure in a lasting way. Potentials of such alterations are discussed, with special reference to the possible interference of the pesticide on the successful synthesis of the supporting connective sheaths.
Pilar Honrubia
M
M
Dpto. Biología Celular y Anatomía, Universidad de León, Spain.
Paz Herráez
M
M
Alvarez
R
R
D000818:Animals; D002219:Carbamates / Q000633:toxicity*; D005704:Gallbladder / Q000187:drug effects / Q000473:pathology*; D007814:Larva / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D009672:Notochord / Q000187:drug effects / Q000473:pathology*; D011743:Pyrimidines; D011898:Ranidae; D015996:Survival Rate
D002219:Carbamates; D011743:Pyrimidines; C011994:pirimicarb