Chronic hypomagnesemia and hypokalemia due to renal wasting in siblings.
A 13 year old girl with carpopedal spasm is presented. Investigation values showed hypomagnesemia and hypokalemia. Her younger brother and sister demonstrated the same biochemical abnormalities without any symptoms. Their urinary excretion of magnesium and potassium were inappropriately high compared with their serum levels. Treatment with oral magnesium sulfate failed to correct the abnormalities, but serum levels of magnesium and potassium were just below the lower limits. This familial disease may represent congenital renal wasting of magnesium and potassium.
Iwata
F
F
Department of Pediatrics, Tobu Regional Hospital, Tokyo, Japan.
Hanawa
Y
Y
Takashima
H
H
D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D004573:Electrolytes / Q000652:urine; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000652:urine; D008275:Magnesium Deficiency / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000652:urine; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008297:Male; D015499:Renal Tubular Transport, Inborn Errors / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000652:urine; D013577:Syndrome
D004573:Electrolytes; D008278:Magnesium Sulfate