title: The maintenance of self-tolerance.
abstract: Two signal models for lymphocyte activation build on the Talmage/Burnet concept that receptor diversity is generated within the immune system by a random process, and that individual lymphocytes carry a single receptor on their surface that determines their specificity. Such models cannot use a concept of signal one anergy (or deletion) to explain the maintenance of self-tolerance in terms of the Bretscher/Cohn theory if they abandon the concept of associative recognition.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262.
authors.forename: K J
authors.initials: KJ
authors.lastname: Lafferty
authors.forename: R G
authors.initials: RG
authors.lastname: Gill
mesh_terms: D000486:Allergy and Immunology / Q000266:history; D000818:Animals; D015551:Autoimmunity; D049673:History, 20th Century; D006801:Humans; D007108:Immune Tolerance; D007519:Isoantigens / Q000276:immunology; D008213:Lymphocyte Activation / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D014181:Transplantation Immunology
chemical_list: D007519:Isoantigens