title: Enhanced mass resolving power, sensitivity, and selectivity in laser desorption Fourier transform ion cyclotron resonance mass spectrometry by ion axialization and cooling.
abstract: Ion cooling and axialization produced by azimuthal quadrupolar excitation in the presence of ion-neutral collisions are applied to laser desorption Fourier transform ion cyclotron resonance mass spectrometry (LD/FT/ICR-MS). With this technique, the large kinetic and internal energies of ions generated by laser desorption processes can be cooled effectively by collisions of ions with neutral argon atoms (at > 5 x 10(-7) Torr). After sufficient cooling in the source compartment of a dual ion trap, the axialized ions may be transferred to the analyzer compartment for detection at much lower pressure (and thus much higher mass resolving power). Enhancements in both FT/ICR mass resolving power and sensitivity are observed; moreover, ion isolation with high selectivity at high pressure is also demonstrated.
authors.affiliation: Department of Chemistry, Ohio State University, Columbus 43210.
authors.forename: S
authors.initials: S
authors.lastname: Guan
authors.forename: M C
authors.initials: MC
authors.lastname: Wahl
authors.forename: T D
authors.initials: TD
authors.lastname: Wood
authors.forename: A G
authors.initials: AG
authors.lastname: Marshall
mesh_terms: D001128:Argon; D003080:Cold Temperature; D005583:Fourier Analysis; D007700:Kinetics; D013058:Mass Spectrometry; D011312:Pressure; D012235:Rhodamines / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D012235:Rhodamines; C026188:rhodamine 6G; D001128:Argon