[The role of photomodification, prevented by lipid peroxidation inhibitors, in the therapeutic effect of UV-irradiated blood in peritonitis in rats].
The blood of healthy animals was irradiated at 254 nm with incident dose 0.05 Einstein/m2 and was thirdly infused to the rats in volume 2 ml/Kg body weight. The infusion of irradiated blood decreased the lethality of rats. Maximal therapeutic action was observed at 7-9th day after peritonitis induction. This effect was completely inhibited by injection the cyclooxygenase inhibitors aspirin or indomethacin (but not lipid antioxidants BHT or alpha-tocopherol) into irradiated portion of blood before irradiation. The therapeutic effect of irradiated blood is due to cyclooxygenase activation by UV-radiation.
Sokolov
A Iu
AIu
Anosov
A K
AK
Roshchupkin
D I
DI
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001769:Blood / Q000378:metabolism / Q000528:radiation effects*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010538:Peritonitis / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D001241:Aspirin; D007213:Indomethacin
Rol' fotomodifikatsiĭ, predotvrashchaemykh ingibitorami peroksidatsii lipidov, v lechebnom deĭstvii UF-obluchennoĭ krovi pri peritonite u krys.