title: [PreS-sequence of the hepatitis B virus envelope: molecular biology and immunology].
abstract: Current data on molecular biology and immunology of the proteins of hepatitis B viral capsid encoded by the preS-region of HBV genome are reviewed. Main attention is paid to study of the immune properties of the capsid proteins, to search of immune dominant epitopes encoded in preS-sequences. The medical and biological significance of the research is shown as exemplified by search of preS-antigens and anti-preS-antibodies in serum from patients suffering hepatitis B. The use of preS-sequences as components of vaccine preparations is discussed.
authors.forename: I V
authors.initials: IV
authors.lastname: Sominskaia
authors.forename: S M
authors.initials: SM
authors.lastname: Sergeeva
authors.forename: P P
authors.initials: PP
authors.lastname: Pumpen
mesh_terms: D000914:Antibodies, Viral; D016679:Genome, Viral; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D016056:Immunodominant Epitopes; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D016056:Immunodominant Epitopes; D014759:Viral Envelope Proteins
vernacular_title: PreS-posledovatel'nosti obolochki virusa gepatita B: molekuliarnaia biologiia i immunologiia.