title: Antifungal macrocyclic polylactones from Penicillium verruculosum.
abstract: Three macrocyclic polylactones have been isolated from Penicillium verruculosum. Two were found to be novel and the third to be identical with NG-012(1). Their structures were elucidated by spectroscopic and chemical methods. A full assignment of 1H- and 13C-resonances in acetone-d6 are given for all three compounds. The compounds show antifungal activity.
authors.affiliation: Novo Nordisk A/S, Plant Protection Division, Bagsvaerd, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Breinholt
authors.forename: G W
authors.initials: GW
authors.lastname: Jensen
authors.forename: R I
authors.initials: RI
authors.lastname: Nielsen
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: J C
authors.initials: JC
authors.lastname: Frisvad
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010407:Penicillium / Q000145:classification / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D007783:Lactones; D010636:Phenols; C078926:NG 011; C082788:BK223 C