title: Comparison of the virulence for mice of Mycobacterium avium and Mycobacterium intracellulare identified by DNA probe test.
abstract: The virulence of various serovars of Mycobacterium avium and M. intracellulare identified by DNA probe test was compared with each other. We found species- and serovar-dependencies of M. avium complex (MAC) virulence to mice in terms of mortality, incidence of lung lesions and bacterial load in the visceral organs, as follows. First, human- or environment-derived M. intracellulare was more virulent for mice, as compared to M. avium isolated from patients or environmental sources. Second, the virulence of MAC isolates belonging to serovars 1, 8, 9 (M. avium), 14 and 16 (M. intracellulare) is in the order of serovars 16 > 14 > 8 > 1 > 9. These aspects were different from those for MAC virulence to human and bird, swine and cattle.
authors.affiliation: Department of Microbiology and Immunology, Shimane Medical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tomioka
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: D J
authors.initials: DJ
authors.lastname: Dawson
mesh_terms: D000818:Animals; D015342:DNA Probes; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009162:Mycobacterium avium / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D015269:Mycobacterium avium Complex / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D012703:Serotyping; D016019:Survival Analysis; D014376:Tuberculosis / Q000662:veterinary*; D014774:Virulence
chemical_list: D015342:DNA Probes