A new neuritogenetic compound BU-4514N produced by Microtetraspora sp.
A novel neuritogenetic compound BU-4514N was isolated from the fermentation broth of Microtetraspora sp. T689-92. It showed significant NGF-mimic activity and antibacterial activity against Gram-positive bacteria. Structural studies revealed that BU-4514N was a new chemotype antibiotic related to lydicamycin.
Toda
S
S
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Yamamoto
S
S
Tenmyo
O
O
Tsuno
T
T
Hasegawa
T
T
Rosser
M
M
Oka
M
M
Sawada
Y
Y
Konishi
M
M
Oki
T
T
D000192:Actinomycetales / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009414:Nerve Growth Factors / Q000737:chemistry; D016501:Neurites; D016716:PC12 Cells / Q000187:drug effects / Q000648:ultrastructure; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009414:Nerve Growth Factors; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C082416:BU 4514N