[Biochemical parameters in the blood in patients during open-heart surgery. II. Malondialdehyde, superoxide dismutase and catalase as indicators of formation and elimination of free oxygen radicals].
Investigation of cardiosurgical patients have provided evidence for the generation of free oxygen radicals during open heart surgery. The finding of increased plasma malondialdehyde concentrations, considered to be an indicator of lipid peroxidation in cell membranes, is suggestive of this process. Simultaneously, the antiradical capacity of tissue was found to exhibit a decreasing trend, as established by the levels of superoxide dismutase and catalase in erythrocytes of peripheral blood which tended to diminish. The funding that no changes in the studied parameters were observed in the blood from the coronary sinus taken before and after interruption of coronary blood flow demonstrates that the commonly applied protection of the myocardium by hypothermic cardioplegic solution and topical cooling of the heart is effective in suppressing radical formation. (Fig. 5, Ref. 36.)
Barta
E
E
Ustav kardiovaskulárnych chorôb v Bratislave, Slovakia.
Cornák
V
V
Pechán
I
I
Luknárová
O
O
Verchovodko
P
P
Rendeková
V
V
D000328:Adult; D006348:Cardiac Surgical Procedures; D002374:Catalase / Q000097:blood*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D007432:Intraoperative Period; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
D005609:Free Radicals; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase
Sledovanie niektorých biochemických parametrov v krvi pacientov pocas operácie na otvorenom srdci. II. Malóndialdehyd, superoxiddismutáza a kataláza ako indikátory tvorby a odstranovania vol'ných kyslíkových radikálov.