Psychiatric manifestations of olivo-ponto-cerebellar atrophy and treatment with clozapine.
Patients with multiple system atrophy, a neurodegenerative disease entity, have a high incidence of associated mental disturbances such as a mood disorder with or without psychotic features. Treatment of the psychiatric symptoms, without compromising neurological status, is often complicated and unsuccessful. This article describes a patient with olivo-ponto-cerebellar atrophy and treatment-resistant psychotic depression whose psychiatric symptoms were successfully treated with clozapine without aggravating the neurological disabilities.
Parsa
M A
MA
University Hospitals of Cleveland, Ohio.
Simon
M
M
Dubrow
C
C
Ramirez
L F
LF
Meltzer
H Y
HY
D003024:Clozapine / Q000627:therapeutic use*; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D009849:Olivopontocerebellar Atrophies / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology
D003024:Clozapine