Effect of life in a constant light environment on the course of hypertension in Dahl rats.
An important goal for biobehavioral scientists is to evaluate treatments that might extend life in the presence and absence of disease. The prototypic example of such a treatment is food restriction. Importantly, we have shown that exposure to a life-long environment of constant light extends life in hamsters with severe, life-threatening heart disease. The purpose of this experiment was to determine whether constant light would also extend the life of rats with an inherited form of hypertension. Constant light neither delayed the progression of hypertension nor extended life in this model. These data suggest that constant light may have a more limited use as an experimental therapeutic modality to extend life as compared to food restriction.
Natelson
B H
BH
Neurobehavioral Unit (127A), VA Medical Center, East Orange, NJ 07018.
Servatius
R J
RJ
Tapp
W N
WN
Gross
J L
JL
Ottenweller
J E
JE
D000311:Adrenal Glands / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008027:Light; D008297:Male; D009929:Organ Size / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains