Protection against Rh D-haemolytic disease of the newborn by a diminished transport of maternal IgG to the fetus.
IgG present in the circulation of newborn infants is predominantly of maternal origin. In cases of severe Rh D alloimmunization, the maternal anti-D anti-bodies may lead to Rh D-haemolytic disease of the newborn. However, an impaired placental transport of maternal IgG could be associated with the protection of the fetus/newborn against haemolytic disease as shown in this case report.
Dooren
M C
MC
Department of Immunohaematology, Central Laboratory of The Netherlands, Red Cross Blood Transfusion Service, Amsterdam.
Engelfriet
C P
CP
D001692:Biological Transport / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D004899:Erythroblastosis, Fetal / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology*; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000097:blood*
D007074:Immunoglobulin G; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen