title: Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats.
abstract: The effects of tetrahydroberberine (THB) on ischemic and reperfused myocardium were studied in comparison with verapamil (Ver). In anesthetized rats, THB and its analogues, l-THP and l-SPD, reduced the infarct size after 4 h of left anterior descending coronary artery (LAD) ligation. In Langendorff hearts, in common with Ver, THB 1 and 10 mumol.L-1 markedly decreased the incidences of ventricular tachycardia (VT) and ventricular fibrillation (VF) in the reperfusion period. The malondialdehyde content and xanthine oxidase activity were also decreased in global ischemic-reperfused hearts pretreated with THB (P < 0.01, or P < 0.05). It suggested that THB could protect the myocardium from ischemic and reperfusion injury.
authors.affiliation: Department of Pharmacology, Nanjing Medical College, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: B
authors.initials: B
authors.lastname: Xuan
authors.forename: D X
authors.initials: DX
authors.lastname: Li
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D001600:Berberine Alkaloids / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000889:Anti-Arrhythmia Agents; D001600:Berberine Alkaloids; D001599:Berberine; C010513:stepholidine; C014215:tetrahydropalmatine; D008315:Malondialdehyde; D014700:Verapamil; D014969:Xanthine Oxidase; C004645:canadine