title: Oral absorption and bioavailability of fenbendazole in the dog and the effect of concurrent ingestion of food.
abstract: Fenbendazole was administered orally without food to six beagle dogs at 2.5, 5.0, 10, 20, 40 and 80 mg/kg of body weight. Increasing the dose rate did not significantly increase the amount of fenbendazole absorbed. In a separate study fenbendazole was administered to the same six beagle dogs at a dose rate of 20 mg/kg of bodyweight in food with high, medium and low fat content. The food provided 1.52, 0.70 or 0.34 g of fat per kg of body weight. Administration of fenbendazole in food with different fat contents did not affect its relative bioavailability. Administration of fenbendazole at a dose rate of 20 mg/kg in food, irrespective of fat content, did however significantly increase its bioavailability when compared to administration of the same dose as a bolus on an empty stomach.
authors.affiliation: Department of Veterinary Pharmacology, University of Glasgow Veterinary School, UK.
authors.forename: Q A
authors.initials: QA
authors.lastname: McKellar
authors.forename: E A
authors.initials: EA
authors.lastname: Galbraith
authors.forename: P
authors.initials: P
authors.lastname: Baxter
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001562:Benzimidazoles / Q000097:blood; D001682:Biological Availability; D004041:Dietary Fats / Q000494:pharmacology*; D004285:Dogs / Q000378:metabolism*; D004435:Eating; D005273:Fenbendazole / Q000493:pharmacokinetics*; D005502:Food; D007408:Intestinal Absorption
chemical_list: D001562:Benzimidazoles; D004041:Dietary Fats; D005273:Fenbendazole; C011030:oxfendazole