title: [Acute bronchospasm due to periwinkle alkaloid and mitomycin association].
abstract: We report six cases in which patients presented with acute dyspnoea following injections of either vindesine or vinorelbin. These patients were receiving chemotherapy in association with cisplatin, mitomycin, and vindesine or vinorelbin, for inoperable bronchial cancer. Three of the patients had evidence of airflow obstruction before these incidents. The clinical picture suggested bronchospasm and appeared in the two hours following an injection of the vinca alkaloid and a significant time away from the administration of the mitomycin. Additional respiratory support was necessary in one patient, the bronchial spasm stopped spontaneously in three cases, and following bronchodilator in two. The respiratory toxicity of vinca alkaloids (vindesine, vinblastin) was observed in 4% of the cases, uniquely when they were associated with mitomycin. Vinorelbin seems to possess the same respiratory toxicity. The bronchospasm, sometimes very severe, seems to occur in the two hours following the injection in the case of the cytotoxics and some time after the administration of mitomycin. The recurrence of the bronchospasm is a constant feature when the vinca alkaloid is readministered. This side effect is different to the pulmonary fibrosis due to mitomycin. Clinical follow up and spirometry is thus necessary in those patients receiving chemotherapy in which vinca alkaloids and mitomycin are associated and the regime should be followed after each administration of a vinca derivative. After the first episode of dyspnoea, it is probably wise to stop the administration of these anti-mitotics to prevent any further respiratory side-effects which could be more severe.
authors.affiliation: Département des maladies respiratoires, Hôpital Sainte-Marguerite, Marseille.
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Pradal
authors.forename: H
authors.initials: H
authors.lastname: Le Caer
authors.forename: D
authors.initials: D
authors.lastname: Montcharmont
authors.forename: D
authors.initials: D
authors.lastname: Vervloet
authors.forename: J P
authors.initials: JP
authors.lastname: Kleisbauer
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001984:Bronchial Neoplasms / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D008937:Mitomycins / Q000008:administration & dosage / Q000009:adverse effects; D012008:Recurrence; D012121:Respiration, Artificial; D013147:Spirometry; D014751:Vindesine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents; D008937:Mitomycins; D014751:Vindesine
vernacular_title: Bronchospasme aigu d à l'association alcaloïde de la pervenche-mitomycine.