T-cell responsiveness to LCMV segregates as a single locus in crosses between BALB/cA and C.B-17 mice. Evidence for regulation by a gene outside the Igh region.
The course of systemic infection with lymphocytic choriomeningitis virus (LCMV) was studied in BALB/cA and C.B-17 mouse strains differing in the immunoglobulin heavy chain region (Igh). Susceptibility to intracerebral infection and the ability to clear the virus differed significantly between these presumably congenic strains, suggesting that a gene in the Igh region might influence the course of this infection. A difference in virus spread prior to appearance of the immune response could not explain the observed differences. On the other hand, the differences in course of infection correlated with a difference in virus-specific T-cell responsiveness measured in terms of virus-specific cytotoxicity in vitro and delayed-type hypersensitivity in vivo. Analysis of F1, BC1 and F2 progeny showed that differential T-cell responsiveness was influenced by a single gene or gene complex; however, no linkage was found between this locus and the Igh-C region. Taken together, these results indicate that an additional, and previously unknown, genetic difference exists between these two mouse strains, and that the involved locus carries a gene which significantly affects T-cell responsiveness to LCMV.
Christensen
J P
JP
Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark.
Marker
O
O
Thomsen
A R
AR
D000818:Animals; D003433:Crosses, Genetic; D005803:Genes, Immunoglobulin / Q000235:genetics*; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D006968:Hypersensitivity, Delayed / Q000235:genetics / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008216:Lymphocytic Choriomeningitis / Q000235:genetics* / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013154:Spleen / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology*
D007143:Immunoglobulin Heavy Chains