Synergy characterization for Enterococcus faecalis strains displaying moderately high-level gentamicin and streptomycin resistance.
Synergy of 14 Enterococcus faecalis strains displaying moderately high-level aminoglycoside resistance (MICs, 500 and 256 to 1,000 micrograms/ml for gentamicin and streptomycin, respectively) was characterized by time-kill studies. All strains proved resistant to penicillin plus the respective aminoglycoside. Strains with moderately high-level aminoglycoside resistance should be considered to exhibit high-level resistance in severe infections.
Bantar
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Laboratorio de Bacteriología Clínica, Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina.
Micucci
M
M
Fernandez Canigia
L
L
Smayevsky
J
J
Bianchini
H M
HM
D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013307:Streptomycin / Q000008:administration & dosage / Q000494:pharmacology*
D005839:Gentamicins; D013307:Streptomycin