title: Alveolar-arterial oxygen gradient in acute chest syndrome of sickle cell disease.
abstract: In 44 episodes of acute chest syndrome of sickle cell disease occurring in 37 children, simple clinical severity score, duration of hospital stay, transfusion data, and alveolar-arterial oxygen gradient were analyzed as indicators of severity of disease. The alveolar-arterial oxygen gradient, measured during breathing of room air, proved, on multivariate analysis, to be the strongest predictor of both clinical severity and the need for blood transfusion.
authors.affiliation: State University of New York-Children's Medical Center of Brooklyn 11203.
authors.forename: U
authors.initials: U
authors.lastname: Emre
authors.forename: S T
authors.initials: ST
authors.lastname: Miller
authors.forename: S P
authors.initials: SP
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Rao
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000628:therapy; D001158:Arteries; D001784:Blood Gas Analysis; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005260:Female; D006450:Hemoglobin SC Disease / Q000150:complications / Q000628:therapy; D006801:Humans; D007223:Infant; D008171:Lung Diseases / Q000097:blood* / Q000209:etiology*; D008297:Male; D015999:Multivariate Analysis; D011650:Pulmonary Alveoli / Q000098:blood supply; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013577:Syndrome; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy