title: Role of the transcription activator virF and the histone-like protein YmoA in the thermoregulation of virulence functions in yersiniae.
abstract: The chromosome of Y. enterocolitica encodes a heat-stable enterotoxin, Yst, being related to STI. The capacity to produce Yst generally disappears during storage of the strains. In these strains, the yst gene is intact but remains silent. The pYV plasmid encodes the eleven secreted antihost proteins called Yops as well as the outer membrane protein YadA. The Yops are secreted by a novel, pYV-encoded secretion mechanism. This mechanism which does not involve the removal of an N-terminal signal sequence, is encoded by the pYV virA and virC loci. The virC locus contains 13 genes called yscA-M. The virA locus encodes the LcrD membrane protein. The yop, yadA and ysc genes form the yop regulon controlled by transcriptional activator VirF. Transcription of the yop, yadA, ysc and virF genes is controlled by temperature. A chromosome-encoded histone-like protein, called YmoA, is involved in the thermoregulation of the yop regulon, which suggests that this thermoregulation could result from temperature-induced changes in DNA topology. The phenotype of ymoA mutants resembles that of osmZ or drdX mutants of E. coli but YmoA is not the Yersinia homologue of the E. coli histone H1. The YmoA histone is also involved in the silencing of the yst gene.
authors.affiliation: Microbial Pathogenesis Unit, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: G R
authors.initials: GR
authors.lastname: Cornelis
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002876:Chromosomes, Bacterial; D004268:DNA-Binding Proteins; D004768:Enterotoxins / Q000235:genetics; D005798:Genes, Bacterial; D010957:Plasmids; D013696:Temperature; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic; D014774:Virulence / Q000235:genetics / Q000502:physiology; D037521:Virulence Factors; D015008:Yersinia enterocolitica / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D004768:Enterotoxins; D015534:Trans-Activators; D037521:Virulence Factors; C079210:YmoA protein, Yersinia enterocolitica