title: Central serous chorioretinopathy in endogenous hypercortisolism.
abstract: OBJECTIVE
  To examine the potential association of central serous chorioretinopathy with endogenous hypercortisolism (Cushing's syndrome).
  
  
  METHODS
  Ophthalmologic survey of consecutively admitted patients with endogenous Cushing's syndrome.
  
  
  METHODS
  An eye clinic of a research center (National Eye Institute, Bethesda, Md).
  
  
  METHODS
  Sixty consecutive patients with confirmed endogenous Cushing's syndrome.
  
  
  METHODS
  Findings from complete ophthalmologic evaluation.
  
  
  RESULTS
  Three (5%) of 60 patients had one or more episodes of appropriately documented central serous chorioretinopathy. In all cases, the episodes occurred during the period of hypercortisolism.
  
  
  CONCLUSIONS
  Central serous chorioretinopathy is an uncommon manifestation of endogenous Cushing's syndrome. Since central serous chorioretinopathy has been associated with other hypercortisolemic states, we suggest that glucocorticoids may play a role in the development of this disease.
authors.affiliation: Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, National Institutes of Health, Bethesda, Md.
authors.forename: E A
authors.initials: EA
authors.lastname: Bouzas
authors.forename: M H
authors.initials: MH
authors.lastname: Scott
authors.forename: G
authors.initials: G
authors.lastname: Mastorakos
authors.forename: G P
authors.initials: GP
authors.lastname: Chrousos
authors.forename: M I
authors.initials: MI
authors.lastname: Kaiser-Kupfer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015862:Choroid Diseases / Q000150:complications* / Q000209:etiology; D003480:Cushing Syndrome / Q000150:complications*; D005122:Exudates and Transudates; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000175:diagnosis / Q000652:urine; D012164:Retinal Diseases / Q000150:complications* / Q000209:etiology
chemical_list: D005938:Glucocorticoids