title: Decrease of isoprene concentrations in blood during general anesthesia.
abstract: Isoprene is present in human breath and in human blood. The fact that isoprene concentrations in breath are linked to states of sleep and wakefulness led us to study its concentration in blood of 12 patients before, during, and after general anesthesia. Isoprene concentrations in blood of patients before anesthesia were 3.3 +/- 1.6 micrograms/liter. During anesthesia, isoprene concentrations decreased to 0.9 +/- 0.5 micrograms/liter. One hour after the end of anesthesia isoprene increased to levels similar to or higher than the preanesthetic ones.
authors.affiliation: Laboratoire de Pharmacologie et Toxicologie, Centre Hospitalier Universitaire, Angers, France.
authors.forename: A
authors.initials: A
authors.lastname: Cailleux
authors.forename: X
authors.initials: X
authors.lastname: Moreau
authors.forename: A
authors.initials: A
authors.lastname: Delhumeau
authors.forename: P
authors.initials: P
authors.lastname: Allain
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D002070:Butadienes / Q000097:blood*; D005260:Female; D045782:Hemiterpenes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010420:Pentanes; D012890:Sleep / Q000502:physiology
chemical_list: D002070:Butadienes; D045782:Hemiterpenes; D010420:Pentanes; C005059:isoprene