[Biochemical indicators in the blood and liver in rats after administration of beta-escin].
The effect of beta-escin on selected parameters of carbohydrate and lipid metabolism was studied in blood and liver tissue. The aim was to established whether its administration would result in steatosis of the liver. Rats were given sodium salt of beta-escin in water solution orally by gavage in the dose of 10 mg/kg or 70 mg/kg. Analysis of blood samples and liver tissue showed that administration of beta-escin to healthy rats did not induce any substantial changes in the metabolic parameters studied. The rats did not develop steatosis. The biological half-life of antipyrine was only sightly prolonged. (Tab. 3, Fig. 1, Ref. 10.)
Ulicná
O
O
Farmakobiochemické laboratórium LFUK a III. interná klinika LFUK v Bratislave, Slovakia.
Volmut
J
J
Kupcová
V
V
Brixová
E
E
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000097:blood; D004928:Escin / Q000494:pharmacology*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D002241:Carbohydrates; D008055:Lipids; D004928:Escin; D000983:Antipyrine
Sledovanie vybraných biochemických ukazovatel'ov v krvi a peceni potkana po podaní beta-escínu.