Transmembrane signalling through the T-cell-receptor-CD3 complex.
Recent data support the existence of activation motifs within different subunits of the T-cell-receptor-CD3 complex. This architecture generates a receptor composed of discrete modules, each capable of being coupled to an effector pathway. Although new T-cell specific protein tyrosine kinases have recently been identified, the nature of the proximal non-receptor protein tyrosine kinase linking the T-cell receptor complex to essential signalling effectors remains unknown. Developmentally regulated differences in T-cell-receptor-CD3 assembly or stability may lead to the expression of isoforms displaying different sets of activation motifs. Whether this may be the basis of differential signalling during T-cell development is still a matter of speculation.
Malissen
B
B
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
Schmitt-Verhulst
A M
AM
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D016384:Consensus Sequence; D005786:Gene Expression Regulation; D008213:Lymphocyte Activation / Q000502:physiology*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D051076:Proto-Oncogene Proteins c-fyn; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000502:physiology*; D011946:Receptors, Antigen / Q000235:genetics / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D011961:Receptors, Fc / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*
D046911:Macromolecular Substances; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D011946:Receptors, Antigen; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc; C054979:antigen T cell receptor, zeta chain; D011505:Protein-Tyrosine Kinases; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D051076:Proto-Oncogene Proteins c-fyn