title: Immunohistochemical localization of paraquat in skin and eye of rat.
abstract: Immunohistochemical techniques were used to observe the localization of paraquat in the skin and eyes of rats. Paraquat poisoned rats were killed 3 h, 12 h, 24 h, 3 days, 7 days and 10 days after intravenous administration of paraquat. In skin, paraquat was localized in the ducts of sweat glands and sebaceous glands between 3 and 10 days after paraquat injection. In eyes, weak positive findings were observed in nerve fibers of retina between 3 and 10 days after the injection. In cornea, paraquat was localized in epithelial cells at the first 3 h and between 3 and 10 days after paraquat administration. Since skin occupies a vast area of the body in animals, as an organ, it seems to be an important storage pool for the redistribution of paraquat.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nagao
authors.forename: W D
authors.initials: WD
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Itakura
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Yagi
authors.forename: T
authors.initials: T
authors.lastname: Oono
authors.forename: T
authors.initials: T
authors.lastname: Takatori
mesh_terms: D000818:Animals; D005123:Eye / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D010269:Paraquat / Q000493:pharmacokinetics* / Q000506:poisoning; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D010269:Paraquat