NMDA glutamatergic receptors, labelled with [3H]MK-801, in brain samples from drug-free depressed suicides.
Glutamate receptors of the NMDA-subtype were quantitated by binding of [3H]dizocilpine maleate (MK-801) in nine brain regions from 22 suicide victims (20-60 yr), with a firm retrospective diagnosis of depression, who had not recently received antidepressant drugs, and 20 age- and sex-matched controls. [3H]MK-801-binding did not differ between suicides and controls in any region studied. Suicides who died violently did not differ from non-violent suicides and controls. A significative negative correlation was found between age and NMDA receptor-binding in the frontal cortex of suicide victims, but not in controls. This preliminary study provides little evidence for an important role of NMDA-binding sites in the pathophysiology of depression.
Holemans
S
S
Laboratoire de Neurochimie Université Catholique de Louvain, Brussels, Belgium.
De Paermentier
F
F
Horton
R W
RW
Crompton
M R
MR
Katona
C L
CL
Maloteaux
J M
JM
D000328:Adult; D000367:Age Factors; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D003863:Depression / Q000378:metabolism* / Q000473:pathology; D016291:Dizocilpine Maleate / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D017470:Receptors, Glutamate / Q000032:analysis* / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis* / Q000378:metabolism; D013405:Suicide
D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate