title: [Variations in hemostasis and fibrinolysis during the treatment of acute myocardial infarct (AMI) with tissue-type plasminogen activator (TTPA). A study of 17 cases].
abstract: The aim of this trial was to estimate changes in the coagulation and fibrinolysis systems during the thrombolytic treatment with recombinant human tissue-type plasminogen activator (rt-PA) in patients with acute myocardial infarction and correlate with hemorrhagic complications. We studied 17 patients with a 3 hours-continuous systemic infusion of 100 mg of rt-PA. Prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen splits products, plasminogen, alfa-2-antiplasmin (a-2AP) and antithrombin III (AT-III) were performed before, during and after infusion. Most patients showed lengthening coagulation times. Fibrinogen and plasminogen were decreased and PDF was increased. No variations in alpha-2AP or AT-III were observed. The recuperation of fibrinogen levels occurred in 3 hours and there was hyperfibrinogenemia after day 3. No hemorrhagic complication was observed in patients with abnormalities in these coagulation or fibrinolytic tests.
authors.affiliation: Departamento de Hematología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
authors.forename: R
authors.initials: R
authors.lastname: Izaguirre Avila
authors.forename: A
authors.initials: A
authors.lastname: Ruiz de Chávez Cervantes
authors.forename: R
authors.initials: R
authors.lastname: Villavicencio
authors.forename: A
authors.initials: A
authors.lastname: Gómez Trigos
authors.forename: R
authors.initials: R
authors.lastname: Mar Chavira
authors.forename: M del C
authors.initials: Mdel C
authors.lastname: Spíndola
authors.forename: J M
authors.initials: JM
authors.lastname: Casanova
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006470:Hemorrhage / Q000097:blood / Q000209:etiology; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator
vernacular_title: Variaciones en la hemostasia y fibrinolisis durante el tratamiento del infarto agudo del miocardio (IAM) con activador tisular del plasminógeno (atPIG). Estudio de 17 casos.