title: Radiation therapy of giant aggressive keratoacanthomas.
abstract: METHODS
  Giant aggressive keratoacanthoma is a rare destructive subset of keratoacanthoma that frequently involves the facial region, grows rapidly to a large size, and often recurs after surgical management. The effectiveness of ionizing radiation therapy was examined in a retrospective study involving 16 patients; 14 of the tumors had recurred after surgical therapy.
  
  
  RESULTS
  All tumors resolved with satisfactory cosmetic results and without recurrence following a fractionated course of superficial radiation therapy.
  
  
  CONCLUSIONS
  Radiation therapy is an effective therapeutic modality for giant aggressive keratoacanthomas.
authors.affiliation: Department of Dermatology, University of Pennsylvania Medical School, Philadelphia.
authors.forename: H
authors.initials: H
authors.lastname: Goldschmidt
authors.forename: W K
authors.initials: WK
authors.lastname: Sherwin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005148:Facial Dermatoses / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007636:Keratoacanthoma / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged