title: Dengue epidemic in the stage of Rio de Janeiro, Brazil, 1990-1: co-circulation of dengue 1 and dengue 2 serotypes.
abstract: During 1990 and 1991, dengue fever was detected in the State of Rio de Janeiro, Brazil. It occurred in two epidemic waves; one, from January to August 1990, caused predominantly by dengue virus type 1 (DEN-1) the other from October 1990 to May 1991 caused by type 2 virus (DEN-2). Dengue was confirmed by virus isolation and/or IgM capture enzyme-linked immunosorbent assay (MAC-ELISA) in 2109/5964 (35.4%) of the cases. DEN-2 virus was isolated from 180 patients. HAI tests indicated that of these previous infection with DEN-1 had occurred in 130 (72%). The epidemic was classified as dengue fever, but severe and even fatal cases occurred in association with secondary infection.
authors.affiliation: Departamento de Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: R M
authors.initials: RM
authors.lastname: Nogueira
authors.forename: M P
authors.initials: MP
authors.lastname: Miagostovich
authors.forename: E
authors.initials: E
authors.lastname: Lampe
authors.forename: R W
authors.initials: RW
authors.lastname: Souza
authors.forename: S M
authors.initials: SM
authors.lastname: Zagne
authors.forename: H G
authors.initials: HG
authors.lastname: Schatzmayr
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000382:microbiology; D003716:Dengue Virus / Q000145:classification / Q000302:isolation & purification; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D012703:Serotyping
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M