Anaphylactic reaction to ranitidine.
Ranitidine is a well-tolerated H2-receptor antagonist with a furan ring as nucleus. Anaphylactic reactions are seldom reported despite the wide use of the drug. We report a patient who presented an anaphylactic reaction with ranitidine (Zantac). The positive skin prick test and oral challenge suggest type I hypersensitivity. Specific IgE determination by RAST technique and histamine release test with ranitidine were negative. The patient did not react to other H2-receptor antagonists or to another furan-derivative (nitrofurantoin).
Lázaro
M
M
Servicio de Alergia, Hospital Ramón y Cajal, Madrid, Spain.
Compaired
J A
JA
De La Hoz
B
B
Igea
J M
JM
Marcos
C
C
Dávila
I
I
Losada
E
E
D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D011852:Radioallergosorbent Test; D011899:Ranitidine / Q000009:adverse effects*; D012882:Skin Tests
D011899:Ranitidine