title: [Success of cyclosporine therapy in two patients with PSS].
abstract: Two PSS patients, unresponsive to D-penicillamine, steroid, cyclophosphamide and plasma exchange therapy, were treated with cyclosporine. One patient complained scleroderma, dysphagia and dyspnea during movement after treatment with steroid, plasma exchange and cyclophosphamide. He showed a increased Leu3a/2a ratio (6.72). About 3 months after treatment with cyclosporine, these complain decreased with normalization of elevated Leu 3 a/2 a ratio. 1 year after treatment, %DLco increased 86% from 50% and pneumonitis findings of chest X-ray and chest CT were also improved. Another patient who complained Raynaud's phenomenon and scleroderma which had extended over his abdomen despite treatment with steroid and cyclophosphamide. 1 month after treatment with cyclosporine, improvement of these phenomenon were recognized. It is concluded that cyclosporine can be an effective agent in the treatment of PSS.
authors.affiliation: Department of Medicine, Kidney Center Tokyo Women's Medical College.
authors.forename: C
authors.initials: C
authors.lastname: Higuchi
authors.forename: T
authors.initials: T
authors.lastname: Sanaka
authors.forename: H
authors.initials: H
authors.lastname: Nihei
authors.forename: N
authors.initials: N
authors.lastname: Sugino
mesh_terms: D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000188:drug therapy*
chemical_list: D016572:Cyclosporine