Alveolar-arterial oxygen gradient in acute chest syndrome of sickle cell disease.
In 44 episodes of acute chest syndrome of sickle cell disease occurring in 37 children, simple clinical severity score, duration of hospital stay, transfusion data, and alveolar-arterial oxygen gradient were analyzed as indicators of severity of disease. The alveolar-arterial oxygen gradient, measured during breathing of room air, proved, on multivariate analysis, to be the strongest predictor of both clinical severity and the need for blood transfusion.
Emre
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State University of New York-Children's Medical Center of Brooklyn 11203.
Miller
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Rao
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Rao
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D000208:Acute Disease; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000628:therapy; D001158:Arteries; D001784:Blood Gas Analysis; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005260:Female; D006450:Hemoglobin SC Disease / Q000150:complications / Q000628:therapy; D006801:Humans; D007223:Infant; D008171:Lung Diseases / Q000097:blood* / Q000209:etiology*; D008297:Male; D015999:Multivariate Analysis; D011650:Pulmonary Alveoli / Q000098:blood supply; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013577:Syndrome; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy