title: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
abstract: The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
authors.affiliation: Department of Medicine, Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC 27710.
authors.forename: E H
authors.initials: EH
authors.lastname: Corder
authors.forename: A M
authors.initials: AM
authors.lastname: Saunders
authors.forename: W J
authors.initials: WJ
authors.lastname: Strittmatter
authors.forename: D E
authors.initials: DE
authors.lastname: Schmechel
authors.forename: P C
authors.initials: PC
authors.lastname: Gaskell
authors.forename: G W
authors.initials: GW
authors.lastname: Small
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D016229:Amyloid beta-Peptides / Q000378:metabolism; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001057:Apolipoproteins E