Enhanced bFGF gene expression in response to transforming growth factor-beta stimulation of AKR-2B cells.
Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor beta resulted in an induction of basic fibroblast growth factor (bFGF) mRNA and bFGF protein in the stimulated cells. In contrast to bFGF, acidic fibroblast growth factor (aFGF) was not induced by TGF beta. The mitogenic effect of transforming growth factor beta on AKR-2B cells may be mediated by the induction of bFCF in these cells.
Pertovaara
L
L
Department of Pathology, University of Helsinki, Finland.
Saksela
O
O
Alitalo
K
K
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D051379:Mice; D012333:RNA, Messenger / Q000096:biosynthesis; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000494:pharmacology*
D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D016212:Transforming Growth Factor beta; D016222:Fibroblast Growth Factor 2