title: Biogenic amines regulate avian immunity.
abstract: Alzet mini-osmotic pumps were implanted subcutaneously to administer norepinephrine (NE) and epinephrine (E) to 6-wk-old line UNH 105 chickens. Dose-time studies showed the most effective NE and E dose and exposure time on two chicken cellular immune responses: the phytohemagglutinin (PHA) wattle response and leukocyte migration. Administration of 1 microgram/h NE for 72 h suppressed significantly the wattle stimulation index [2.48 +/- .3 (SE)] compared to that of saline controls (4.1 +/- .3) but enhanced mean leukocyte migration (7.7 +/- .3 versus 4.9 +/- .3). Epinephrine at 1 microgram/h for 72 h significantly suppressed the wattle index (1.8 +/- .2) compared to that of controls (2.8 +/- .3) but E at 1 microgram/h for 48 h enhanced leukocyte migration (9.5 +/- .2 versus 6.4 +/- .2). Continuous administration of NE and E at physiological levels alters cell-mediated immunity and appears to have an immune regulatory role in the chicken.
authors.affiliation: Department of Biology, Central Michigan University, Mt. Pleasant 48859.
authors.forename: F M
authors.initials: FM
authors.lastname: McCorkle
authors.forename: R L
authors.initials: RL
authors.lastname: Taylor
mesh_terms: D000818:Animals; D002464:Cell Migration Inhibition; D002645:Chickens / Q000276:immunology*; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage*; D010835:Phytohemagglutinins; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D010835:Phytohemagglutinins; D009638:Norepinephrine; D004837:Epinephrine