title: Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum.
abstract: Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.
authors.affiliation: Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492.
authors.forename: F
authors.initials: F
authors.lastname: Mayerl
authors.forename: Q
authors.initials: Q
authors.lastname: Gao
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: S E
authors.initials: SE
authors.lastname: Klohr
authors.forename: J A
authors.initials: JA
authors.lastname: Matson
authors.forename: D R
authors.initials: DR
authors.lastname: Gustavson
authors.forename: D M
authors.initials: DM
authors.lastname: Pirnik
authors.forename: R L
authors.initials: RL
authors.lastname: Berry
authors.forename: C
authors.initials: C
authors.lastname: Fairchild
authors.forename: W C
authors.initials: WC
authors.lastname: Rose
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D014334:Tropolone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; C082786:eupenifeldin; D014334:Tropolone