title: Oral 1,25(OH)2D3 pulse therapy for the treatment of secondary hyperparathyroidism.
abstract: We examined the effect of oral 1,25(OH)2D3 pulse therapy in hemodialyzed patients with secondary hyperparthyroidism (2 degrees HPT). Prescription of 6.0 micrograms 1,25(OH)2D3 once a week combined with calcium carbonate as a phosphate binder during the last 5 days a week for 12 weeks resulted in improvement of mild to moderate 2 degrees HPT despite no significant differences in serum total calcium and phosphate concentration. In addition, the effect was greater in cases with mild 2 degrees HPT. A single administration of 6 micrograms 1,25(OH)2D3 reduced the parathyroid hormone concentration in patients with mild 2 degrees HPT or with a short duration of hemodialysis. Tmax of the serum 1,25(OH)2D3 after single administration of 6.0 micrograms 1,25(OH)2D3 was individually different (range, 0.4-20.9 hrs). It is recommended that early employment of oral 1,25(OH)2D3 pulse therapy be undertaken once a week combined with prescription of calcium salt as a phosphate binder during the last 5 days a week for the treatment of 2 degrees HPT refractory to conventional therapy, since there is no risk of aluminum accumulation with satisfactory control of the serum total calcium and phosphate concentration.
authors.affiliation: Nishi-Kofu National Hospital, Yamanashi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Kinosita
authors.forename: M
authors.initials: M
authors.lastname: Yanai
authors.forename: T
authors.initials: T
authors.lastname: Kuno
authors.forename: Y
authors.initials: Y
authors.lastname: Nagura
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002117:Calcitriol / Q000008:administration & dosage / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy*; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D002117:Calcitriol; D002119:Calcium Carbonate