Signal transduction events leading to T-cell lymphokine gene expression.
The expression of T-cell derived lymphokines is regulated by signal transduction events initiated by the T-cell antigen receptor and other T-cell surface molecules. Substantial progress has been made in characterizing the signal transduction events initiated at the plasma membrane of the T cell and their targets which control lymphokine gene expression in the nucleus. This review will summarize recent progress in this area of investigation.
Fraser
J D
JD
Dept of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143.
Straus
D
D
Weiss
A
A
D000818:Animals; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D008222:Lymphokines / Q000235:genetics*; D010750:Phosphoproteins / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D008222:Lymphokines; D010750:Phosphoproteins; D011948:Receptors, Antigen, T-Cell