title: Effect of ticlopidine on the cutaneous circulation in peripheral vascular disease.
abstract: To assess the effect of ticlopidine on the cutaneous circulation, 25 patients with lower limb ischemia were investigated just before and at two hours after being given a 200 mg oral dose of ticlopidine. The transcutaneous partial pressure of oxygen (PtcO2) and the skin temperature were determined at 35 limb sites and 9 chest walls sites. Both the PtcO2 and the skin temperature were significantly increased at two hours after the administration of ticlopidine (p < 0.01). The findings suggest that ticlopidine can improve the cutaneous microcirculation in patients with peripheral vascular disease.
authors.affiliation: 1st Department of Surgery, Tokyo Medical and Dental University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Qian
authors.forename: T
authors.initials: T
authors.lastname: Iwai
mesh_terms: D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous; D004341:Drug Evaluation; D005260:Female; D005734:Gangrene / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D007511:Ischemia / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D012867:Skin / Q000098:blood supply* / Q000187:drug effects*; D012881:Skin Temperature / Q000187:drug effects; D013909:Thorax; D013988:Ticlopidine / Q000627:therapeutic use*
chemical_list: D013988:Ticlopidine