[Distribution of harringtonine positively and negatively charged liposome in rat tissues].
Distribution of harringtonine positively and negatively charged liposome (HL(+), HL(-)) and harringtonine free drug (FH) in rat tissues were measured by HPLC. Their LD50 in mice were compared. The results showed that distribution of HL(+), HL(-), In vivo may be changed, that the amount of HL(+), HL(-) was increased in the liver, lung, and spleen and in these tissues it was 2-30-fold higher than that of HF after iv 2 h. HL(+), HL(-) may aid to permeate through the blood-brain, blood-testicle barrier, and to reduce acute lethal toxicity. Areas under the time curve of HL(+), HL(-) in brain and testis within 2 h were 2-4.5 times as much as those of HF. There were significant differences in the fate between negatively and positively charged liposomes in vivo.
Wu
H L
HL
Nanjing Institute of Materia Medica, Nanjing, China.
Weng
G Y
GY
Zhou
X M
XM
Cheng
D D
DD
D000818:Animals; D001812:Blood-Brain Barrier; D001814:Blood-Testis Barrier; D004337:Drug Carriers; D005260:Female; D006248:Harringtonines / Q000493:pharmacokinetics* / Q000633:toxicity; D008081:Liposomes; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D004337:Drug Carriers; D006248:Harringtonines; D008081:Liposomes; C062500:harringtonin