The effect of 1,4-dihydropyridine and 1,4-dihydroindeno[1,2-b]pyridine derivatives on glutathione S-transferase activity in vitro.
The 1,4-dihydropyridine (1,4-DHP) and 1,4-dihydroindeno[1,2-b]pyridine (1,4-DHIP) derivatives were investigated as glutathione S-transferase (GT) inhibitors. The obtained results indicate that some of the 1,4-DHP's containing lipophylic and bulky substituents have inhibitory effects on GT in vitro. The derivatives of 1,4-DHIP are more pronounced inhibitors.
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Laboratory of Membrane Active Compounds of Latvian Institute of Organic Synthesis, Riga.
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Vigante
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Duburs
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D000818:Animals; D002417:Cattle; D004095:Dihydropyridines / Q000494:pharmacology*; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology; D011725:Pyridines / Q000494:pharmacology*
D004095:Dihydropyridines; D011725:Pyridines; C038806:1,4-dihydropyridine; D005982:Glutathione Transferase