Non-traumatic rhabdomyolysis complicating antihistamine overdose.
Antihistamines are common over the counter medications which are frequently involved in overdoses. The usual clinical course is dominated by the anticholinergic affects of these agents; it includes significant autonomic and central nervous system effects and direct cardiac toxicity (1). We report a case of a suicide attempt in a young adult male where ingestion of the antihistamines diphenhydramine and doxylamine was complicated by non-traumatic rhabdomyolysis and acute renal failure.
Frankel
D
D
Renal Division, Erie County Medical Center, Buffalo, NY 14215.
Dolgin
J
J
Murray
B M
BM
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D000328:Adult; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004155:Diphenhydramine / Q000506:poisoning*; D004319:Doxylamine / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D013406:Suicide, Attempted
D004155:Diphenhydramine; D004319:Doxylamine; D003404:Creatinine