[The effect of bromocryptin on rotational activity in rats].
The experiments were made in rats with unilateral lesion to the nigrostriatal tract, which was induced by the highly active dopaminergic neurotoxin 1-methyl-4-phenyl-pyridinium. The rotational activity of rats was evaluated after intragastric and subcutaneous bromocryptine given in a single dose of 10 mg/kg and 25 mg/kg one, two, three and four times. The highest effect of the drug was seen when it was used in the maximum dose of 25 mg/kg, but when the agent is repeatedly given in the above dose, it failed to enhance the rotational activity of rats. The findings may provide evidence for possibilities of increasing the doses of bromocryptine in practical medicine, and for designing the injectable dosage form of the drug.
Omel'nitskiĭ
P P
PP
Sokolov
S Ia
SIa
Kucherianu
V G
VG
Atadzhanov
M A
MA
D015655:1-Methyl-4-phenylpyridinium; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D012399:Rotation; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D001971:Bromocriptine; D015655:1-Methyl-4-phenylpyridinium
Vliianie bromokriptina na rotatsionnuiu aktivnost' krys.