Endothelin-1-induced gastric ulcer is attenuated by cetraxate.
We investigated the effect of the anti-ulcer drug cetraxate on the development of the gastric ulcer induced by the submucosal injection of endothelin-1 in the rat gastric body, and its effects on gastric mucosal hemodynamics and tissue oxygenation by Laser doppler flowmetry and tissue spectrophotometry. Endothelin-1 induced gastric ulcer (ulcer length: 11.85 +/- 0.89 mm, mean +/- SEM, n = 4) which was strongly attenuated by cetraxate (ulcer length: 3.27 +/- 0.3 mm, mean +/- SEM, n = 8, p < 0.0001). Cetraxate maintained also tissue oxygenation without causing any significant effect on the endothelin-1-induced changes in gastric mucosal blood flow and volume. These results show that cetraxate exerts its cytoprotective action partly by maintaining mucosal oxygenation.
Lazaratos
S
S
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
Kashimura
H
H
Nakahara
A
A
Fukutomi
H
H
Osuga
T
T
Miyauchi
T
T
Goto
K
K
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D016232:Endothelins / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy*; D014148:Tranexamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D016232:Endothelins; C000665:cetraxate; D014148:Tranexamic Acid