title: Placental involvement in paracoccidioidomycosis.
abstract: A case of juvenile-type paracoccidioidomycosis in a pregnant woman is reported. The disease pre-dated pregnancy and antifungal treatment was being administered when she became pregnant. A premature male infant was delivered with no evidence of infection. Microscopic examination of the placenta showed numerous Paracoccidioides brasiliensis yeast forms in the intervillous space, enmeshed in a macrophagic-phagocytic reaction, with damage of the trophoblastic layer. Placental transfer of specific P. brasiliensis antibodies was demonstrated.
authors.affiliation: Departamento de Patologia Clínica, Faculdade de Ciências Médicas da UNICAMP, Campinas, São Paulo, Brazil.
authors.forename: M H
authors.initials: MH
authors.lastname: Blotta
authors.forename: A M
authors.initials: AM
authors.lastname: Altemani
authors.forename: E
authors.initials: E
authors.lastname: Amaral
authors.forename: L J
authors.initials: LJ
authors.lastname: Silva
authors.forename: Z P
authors.initials: ZP
authors.lastname: Camargo
mesh_terms: D000293:Adolescent; D000908:Antibodies, Fungal / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D007136:Immunoglobulins / Q000097:blood; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007958:Leukocyte Count; D008297:Male; D010229:Paracoccidioidomycosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D010920:Placenta / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D013601:T-Lymphocytes / Q000276:immunology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000908:Antibodies, Fungal; D015704:CD4 Antigens; D016827:CD8 Antigens; D007136:Immunoglobulins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination