The acute toxicity and in vivo antitumour activity against L1210 leukemia of triphenyltin 3,5-diisopropylsalicylate, bis (di-n-butyl-(s)-2-pyrrolidone-5-carboxylato)tin oxide and di-n-butyltin bis(3-amino-4-methylbenzoate).
Triphenyltin 3,5-di-isopropylsalicylate, compound 1, is characterized by a maximum tolerated dose (MTD) of 20 mg/kg. Bis[di-n-butyl(2-pyrrolidone-5-carboxylato)tin] oxide, compound 2, and (di-n-butyltin bis(3-amino-4-methyl-benzoate), compound 3, exhibit similar acute toxicities (MTD = 8 mg/kg) despite their lower in vitro activity, as compared to compound 1, against the two human tumor cell lines MCF-7 and WiDr. All three are inactive in vivo against L1210 leukemia in mice.
Gielen
M
M
Free University of Brussels (V.U.B.), Faculty of Applied Sciences, Department of General and Organic Chemistry (AOSC), Belgium.
de Vos
D
D
Meriem
A
A
Boualam
M
M
el Khloufi
A
A
Willem
R
R
D062365:Aminobenzoates / Q000627:therapeutic use / Q000633:toxicity*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009947:Organotin Compounds / Q000627:therapeutic use / Q000633:toxicity*; D011760:Pyrrolidinones / Q000627:therapeutic use / Q000633:toxicity*; D012459:Salicylates / Q000627:therapeutic use / Q000633:toxicity*; D062368:meta-Aminobenzoates
D062365:Aminobenzoates; D000970:Antineoplastic Agents; D009947:Organotin Compounds; D011760:Pyrrolidinones; D012459:Salicylates; D062368:meta-Aminobenzoates; C082973:di-n-butyltin bis(3-amino-4-methylbenzoate); C082971:triphenyltin 3,5-diisopropylsalicylate; C082972:bis(di-n-butyl-2-pyrrolidone-5-carboxylato)tin oxide