[The effect of cerebrocrast and nicardipine on the blood supply and metabolism of the brain in cats with intracranial hemorrhage].
Intravenous cerebrocrast, 1 g/kg/min, and nicardipine, 0.5 g/kg/min, given to cats during 60 min one day after cerebral hemorrhage were found to produce an improvement of cerebral blood supply and oxygen consumption along with a moderate fall of blood pressure. The favourable effect of cerebrocrast on brain oxygen and carbohydrate metabolism was mediated by increased brain blood supply. As compared to cerebrocrast, nicardipine induced a more prolonged antihypertensive response and more pronounced effects on cerebral tissue metabolism, by substantially decreasing brain lactate production.
Chernysheva
G A
GA
Plotnikov
M B
MB
Bisenieks
E A
EA
Makarova
N V
NV
Ul'driks
Ia R
IaR
Dubur
G Ia
GIa
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002415:Cats; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D004095:Dihydropyridines / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects; D009529:Nicardipine / Q000494:pharmacology* / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D004095:Dihydropyridines; D014665:Vasodilator Agents; C073838:2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine; D009529:Nicardipine
Vliianie tserebrokrasta i nikardipina na krovoobrashchenie i metabolizm mozga koshek pri vnutrimozgovom krovoizliianiĭ.