The influence of maternal nicotine exposure on neonatal lung metabolism. Protective effect of ascorbic acid.
The aim of the present study was to establish whether ascorbic acid supplementation (1 mg/kg/body mass/day) during pregnancy and lactation will prevent the effect of maternal nicotine exposure (1 mg/kg/body weight/day) on neonatal lung carbohydrate, DNA and protein metabolism. The data show that the adult lung ascorbic acid content was reduced by 76% after exposure to nicotine. In contrast, maternal nicotine exposure during pregnancy and lactation has no effect on neonatal lung ascorbic acid content. However, ascorbic acid supplementation during pregnancy and lactation prevented the adverse effects of maternal nicotine exposure on neonatal lung carbohydrate, DNA and protein metabolism.
Maritz
G S
GS
Department of Physiological Sciences, University of the Western Cape, Bellville, South Africa.
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001205:Ascorbic Acid / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D005260:Female; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D007774:Lactation; D008168:Lung / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008431:Maternal-Fetal Exchange; D009538:Nicotine / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D007773:Lactates; D009538:Nicotine; D006003:Glycogen; D004247:DNA; D001205:Ascorbic Acid