Toxoplasmosis neuroretinitis.
BACKGROUND
Neuroretinitis is a distinct clinical entity consisting of moderate to severe visual loss, optic nerve head edema, macular exudate in a stellate pattern, and variable vitreous inflammation. Although the etiology is usually postviral or idiopathic, an acute infectious cause occasionally is demonstrated.


METHODS
Five juvenile or young adult patients with neuroretinitis are presented with serologic evidence of Toxoplasma gondii infection. Four of the five patients were treated with systemic antibiotics and corticosteroids; one patient was not treated.


RESULTS
With a mean follow-up period of 50 months, visual acuity returned to 20/25 or better in four patients, with one patient regaining visual acuity of 20/60. Two patients had one or more recurrent episodes of neuroretinitis, distinguishing toxoplasmosis from idiopathic neuroretinitis, which is usually a monophasic illness.


CONCLUSIONS
Toxoplasmosis infection is a rare, but potentially treatable, form of neuroretinitis and should be included in the differential diagnosis of "Leber's idiopathic stellate retinopathy."
Fish
R H
RH
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas.
Hoskins
J C
JC
Kline
L B
LB
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009902:Optic Neuritis / Q000188:drug therapy / Q000469:parasitology* / Q000503:physiopathology; D011241:Prednisone / Q000627:therapeutic use; D012008:Recurrence; D012173:Retinitis / Q000188:drug therapy / Q000469:parasitology* / Q000503:physiopathology; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy / Q000503:physiopathology; D014792:Visual Acuity
D000900:Anti-Bacterial Agents; D011241:Prednisone