title: Anomalous bronchospasm following inhalation of (+) isoprenaline by asthmatics.
abstract: Sympathomimetics (beta-adrenergic agonists) presently used in asthma therapy comprise racemic mixtures of bronchodilator and non-bronchodilator enantiomers. In a randomized, double-blind placebo-controlled study, asthmatic subjects inhaled a nebulized solution of the non-bronchodilator (+) enantiomer of isoprenaline. Substantial decreased forced expiratory volume (FEV1) was detected in 2 patients and of the remaining 8, a single subject had increased reactivity to histamine 7 h after inhalation of (+) isoprenaline. These effects of (+) isoprenaline may contribute to anomalous effects of (+/-) isoprenaline in asthma.
authors.affiliation: Swiss Institute of Allergy and Asthma Research (SIAF), Basel.
authors.forename: T T
authors.initials: TT
authors.lastname: Hansel
authors.forename: F
authors.initials: F
authors.lastname: Schwarz
authors.forename: B
authors.initials: B
authors.lastname: Villiger
authors.forename: R
authors.initials: R
authors.lastname: Naef
authors.forename: B P
authors.initials: BP
authors.lastname: Richardson
authors.forename: J
authors.initials: J
authors.lastname: Morley
mesh_terms: D000280:Administration, Inhalation; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000139:chemically induced*; D004311:Double-Blind Method; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage / Q000009:adverse effects*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
chemical_list: D007545:Isoproterenol