title: Effects of fluvoxamine, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers.
abstract: The effects of fluvoxamine (50 or 100 mg), alone and in combination with ethanol (0.8 g/kg), on psychomotor and cognitive performance and on autonomic nervous system reactivity were studied in healthy male volunteers. Fluvoxamine produced neither serious psychomotor or cognitive impairment nor alterations in autonomic nervous system functioning at these doses. There was no evidence that fluvoxamine exacerbated, or improved, ethanol-induced impairments of memory or any other measures evaluated. Fluvoxamine tended to improve recognition, but not free recall, of words.
authors.affiliation: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892.
authors.forename: M
authors.initials: M
authors.lastname: Linnoila
authors.forename: J M
authors.initials: JM
authors.lastname: Stapleton
authors.forename: D T
authors.initials: DT
authors.lastname: George
authors.forename: E
authors.initials: E
authors.lastname: Lane
authors.forename: M J
authors.initials: MJ
authors.lastname: Eckardt
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood / Q000523:psychology; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D001341:Autonomic Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000493:pharmacokinetics; D016666:Fluvoxamine / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D009638:Norepinephrine / Q000097:blood; D010555:Personality Inventory; D011597:Psychomotor Performance / Q000187:drug effects*; D014706:Verbal Learning / Q000187:drug effects
chemical_list: D000431:Ethanol; D016666:Fluvoxamine; D009638:Norepinephrine