title: Survey of the association of deoxyribonuclease I polymorphism with disease.
abstract: The deoxyribonuclease I (DNase I) system was studied in 120 unrelated Japanese patients with liver disease, malignant neoplasms, alimentary-canal disease and inflammatory conditions with respect to the distribution of phenotypes and gene frequencies in serum samples. In patients with alimentary-canal disease a significant deficit of the DNase I phenotype 1-2 was demonstrated, which suggests that heterozygosity may confer protection against such disease. Furthermore, a significant association between the DNase I phenotype 2 and liver disease was found. The possible involvement of these phenotypes in the response to these diseases would appear to merit further study.
authors.affiliation: Department of Legal Medicine, Fukui Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yasuda
authors.forename: D
authors.initials: D
authors.lastname: Nadano
authors.forename: E
authors.initials: E
authors.lastname: Tenjo
authors.forename: H
authors.initials: H
authors.lastname: Takeshita
authors.forename: M
authors.initials: M
authors.lastname: Nakanaga
authors.forename: K
authors.initials: K
authors.lastname: Kishi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003850:Deoxyribonuclease I / Q000097:blood* / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D003850:Deoxyribonuclease I