[Structural basis of mutagenicity of heterocyclic amines].
The CASE (computer-automated structure evaluation) was used to gain an understanding of the basis of mutagenicity of heterocyclic amines. It was found that the activity of these molecules was dependent upon the amino connected with the carbon in the benzene cycle, and the position of nitrogens in the heterocycle was also important. Both the sensitivity and specificity of the CASE system established in my laboratory approached 1.00.
Fu
Z D
ZD
Shanghai Railway Medical College.
D000588:Amines / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007256:Information Systems; D015394:Molecular Structure; D009153:Mutagens; D013329:Structure-Activity Relationship
D000588:Amines; D006571:Heterocyclic Compounds; D009153:Mutagens