Leukemic dermal infiltrate at the exit site of a central venous catheter.
This report describes the case of a minimally differentiated acute myeloid leukemia (FAB M0) diagnosed in a 55-year-old woman. During a second chemotherapy-induced complete remission, a subcutaneous nodule appeared at the scar of a recently removed Hickman catheter, which when biopsied revealed leukemic infiltration of the dermis and hypodermis. The patient had a bone marrow relapse three weeks later. The authors review similar recent reports and emphasize the importance of recognizing this particular type of cutaneous leukemic relapse.
Martino
R
R
Department of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Sureda
A
A
Sitjas
D
D
Nomdedéu
J
J
Domingo-Albòs
A
A
D000208:Acute Disease; D000677:Amsacrine / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001853:Bone Marrow / Q000473:pathology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology*; D017254:Leukemic Infiltration; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D009366:Neoplasm Seeding; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D016879:Salvage Therapy; D012867:Skin / Q000473:pathology*; D014751:Vindesine / Q000008:administration & dosage
D014408:Biomarkers, Tumor; D000677:Amsacrine; D003561:Cytarabine; D005047:Etoposide; D003520:Cyclophosphamide; D011239:Prednisolone; D008942:Mitoxantrone; D014751:Vindesine; D003630:Daunorubicin