Methods for evaluation of anti-asthma drugs in the primate.
Use of the primate is gaining popularity in the definition of anti-asthma drugs. The present report describes three novel tests of (1) bronchodilatation, (2) hyperreactivity and (3) anti-inflammatory activity in the rhesus monkey. All tests are based on standard clinical techniques and the relevance and application of the tests to subsequent clinical evaluation is addressed.
Foster
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Preclinical Research, Sandoz Pharma AG, Basel, Switzerland.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D008253:Macaca mulatta; D008297:Male
D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents