Intrathecal injection of high-dose meglumine amidotrizoate with complete recovery.
Rarely we are faced with accidental spinal injection of potentially toxic substances. We present 2 cases in which amidetrizoate, water-soluble ionic contrast medium, was accidentally injected intrathecally. Our treatment consisted of vigorous hydration and barbiturate coma. This report suggests that for water-soluble ionic contrast media increasing cerebrospinal fluid circulation by vigorous hydration may be as effective as spinal lavage in diminishing toxicity.
Maruyama
K
K
Department of Anesthesiology, Mie University Hospital, Japan.
Setoguchi
Y
Y
Maruyama
J
J
Shimizu
T
T
Chikusa
H
H
Takeuchi
M
M
Ogihara
Y
Y
Muneyuki
M
M
D000328:Adult; D001921:Brain / Q000187:drug effects*; D003128:Coma / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000628:therapy; D003422:Critical Care / Q000379:methods; D003974:Diatrizoate Meglumine / Q000493:pharmacokinetics / Q000506:poisoning*; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D012640:Seizures / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000628:therapy; D014057:Tomography, X-Ray Computed
D003974:Diatrizoate Meglumine