Secondary localized cutaneous amyloid in Bowen's disease.
A case of Bowen's disease is described in which striking quantities of amyloid were detected in the papillary dermis visualized easily by routine haematoxylin and eosin staining. The material showed positive labelling with an antikeratin monoclonal antibody consistent with the proposed origin of the amyloid as degenerate keratinocytes. The pathobiology of amyloid associated with dysplastic squamous lesions is discussed.
Speight
E L
EL
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Milne
D S
DS
Lawrence
C M
CM
D000682:Amyloid / Q000032:analysis*; D001913:Bowen's Disease / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007866:Leg; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology
D000682:Amyloid