title: Inheritance of intrahepatic cholestasis of pregnancy in one kindred.
abstract: We report three sisters with intrahepatic cholestasis of pregnancy (ICP) and the pedigree of the family, including six generations. ICP was observed in five successive generations; most of the patients also had cholelithiasis. The uniform expression, the complete penetrance of the trait and the direct parent-to-child transmission support the Mendelian dominant mode of inheritance. Determination of HLA A, B and C haplotype was made in five ICP patients, without any findings of HLA type common to everyone. X-linked inheritance cannot be excluded in this study.
authors.affiliation: Department of Obstetrics and Gynaecology, Kanta-Häme Central Hospital, Hämeenlinna, Finland.
authors.forename: M L
authors.initials: ML
authors.lastname: Hirvioja
authors.forename: S
authors.initials: S
authors.lastname: Kivinen
mesh_terms: D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000235:genetics* / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D010375:Pedigree; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology
chemical_list: D006680:HLA Antigens