title: [Augmented activity of the adrenal medulla in young men with positive family history of essential hypertension].
abstract: Serum adrenaline (AD) and noradrenaline (NA) were measured by RIA method in two groups of young males: group S (n = 54) with positive family history of essential hypertension (EH) and group K (n = 9) with negative family history of EH (mean age: 24.6 +/- 3.3 i 23.6 +/- 3.6 years respectively). AD and NA concentrations were estimated in basic conditions (AD1, NA1) and after 10 min of passive vertical posture(AD2, NA2). In group S AD1 concentration was higher than in group K (54.4 +/- 24.4 i 37.8 +/- 15.6 pg/ml respectively, p < 0.05). In group S a positive correlation was found between mean systolic blood pressure (SBP) and mean heart rate (HR) estimated during 5-hours monitoring by Spacelab IGR 5300 ambulatory blood pressure and heart rate monitoring system (r = 0.5, p < or = 0.01). Pearson's correlation coefficient (Pcc). In this same group positive correlations were also found between AD2 and SBP - r = 0.31, p < 0.05 (Pcc) and between AD2 and HR: r = 0.33, p < 0.05 (Pcc). Results of 5-hours blood pressure monitoring showed that 15 of 54 males from group S had SBP > 139 mmHg (group S1). In group S1, AD1 and AD2 concentrations were higher than in group K (AD1: 366 +/- 144; 206 +/- 85, p < 0.01 and AD2: 626 +/- 266; 369 +/- 156 fmol/ml, p < 0.05 respectively). No differences were found in AD1, AD2, NA1 and NA2 concentration between group K and normotensive (SBB < 140 mmHg) males with positive family history of EH: group S2. In young males with positive family history of EH, the elevation of blood pressure might be caused by an augmented activity of the adrenal medulla.
authors.affiliation: Kliniki Nadciśnienia Tetniczego i Chorób Naczyń AM w Warszawie.
authors.forename: M
authors.initials: M
authors.lastname: Czarkowski
authors.forename: K
authors.initials: K
authors.lastname: Chojnowski
authors.forename: M
authors.initials: M
authors.lastname: Osikowska-Loksztejn
authors.forename: J
authors.initials: J
authors.lastname: Chodakowska
mesh_terms: D000313:Adrenal Medulla / Q000503:physiopathology*; D000328:Adult; D004837:Epinephrine / Q000097:blood; D005190:Family; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic; D009638:Norepinephrine / Q000097:blood; D011187:Posture / Q000502:physiology; D011863:Radioimmunoassay
chemical_list: D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Zwiekszona aktywność rdzenia nadnerczy u młodych mezczyzn z rodzinnym ryzykiem pierwotnego nadciśnienia tetniczego.