title: Fatty replacement of bone marrow after radiation therapy for Hodgkin disease: quantification with chemical shift imaging.
abstract: The authors studied the long-term fatty replacement of bone marrow in 23 patients who had received radiation therapy for Hodgkin disease, with T1-weighted magnetic resonance imaging and quantitative chemical shift imaging. T1-weighted images revealed a mostly homogeneous high-signal-intensity pattern, in contrast to the hypointense pattern of nonirradiated marrow. The degree of fatty replacement was objectively assessed with chemical shift imaging, comparing patients to age-matched healthy volunteers. The authors found an increase in relative fat signal of 37% in the thoracic spine and 34% in the lumbar spine. The relative fat signal of nonirradiated pelvic and femoral marrow was decreased by 8%, indicating marrow reconversion. No radiation dose dependence was found in the range from 25 to 50 Gy. No signs of marrow regeneration were observed 15-126 months after radiation therapy. With chemical shift imaging, the degree of long-term radiogenic fatty replacement of the bone marrow can be quantified, confirming the lack of regeneration after radiation therapy for Hodgkin disease.
authors.affiliation: Department of Radiology, German Cancer Research Center, Heidelberg.
authors.forename: H U
authors.initials: HU
authors.lastname: Kauczor
authors.forename: B
authors.initials: B
authors.lastname: Dieti
authors.forename: G
authors.initials: G
authors.lastname: Brix
authors.forename: K
authors.initials: K
authors.lastname: Jarosch
authors.forename: M V
authors.initials: MV
authors.lastname: Knopp
authors.forename: G
authors.initials: G
authors.lastname: van Kaick
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006410:Hematopoiesis / Q000528:radiation effects*; D006689:Hodgkin Disease / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013997:Time Factors