The tyrosine kinase connection: how GPI-anchored proteins activate T cells.
How can crosslinking of cell-surface glycosylphosphatidylinositol-anchored proteins activate T cells when the proteins do not reach the cytosol? Recent results show that glycosylphosphatidylinositol-anchored proteins associate with tyrosine kinases of the src family. Kinase activity is stimulated when glycosylphosphatidylinositol-anchored proteins are crosslinked. How the proteins are linked across the membrane, however, remains an intriguing mystery.
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Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794-5215.
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D004705:Endocytosis; D016391:Genes, src; D017261:Glycosylphosphatidylinositols / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D046911:Macromolecular Substances; D008563:Membrane Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D051379:Mice; D005810:Multigene Family; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051076:Proto-Oncogene Proteins c-fyn; D015398:Signal Transduction / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D017261:Glycosylphosphatidylinositols; D046911:Macromolecular Substances; D008563:Membrane Lipids; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C494957:FYN protein, human; C494960:Fyn protein, mouse; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D051076:Proto-Oncogene Proteins c-fyn