title: Extracorporeal venovenous recirculation for the treatment of hypothermia during elective aortic surgery: a phase I study.
abstract: BACKGROUND
  Hypothermia caused by massive transfusion or prolonged exposure during operation is difficult to reverse and is associated with adverse side effects. This prospective, randomized study evaluated a technique using extracorporeal venovenous recirculation (EVR) through a roller pump-driven device with a commercial countercurrent heat exchanger used for treatment of hypothermia (temperature < 35.5 degrees C) occurring during elective aortic operation.
  
  
  METHODS
  Patients undergoing aortic operation had routine prophylaxis against hypothermia including ventilator cascades, warming blankets, and low-velocity fluid warmers. When core temperature was less than 35.5 degrees C, patients were randomized to continue existing therapy (control, n = 7) or EVR (n = 8), performed through two large-bore venous lines.
  
  
  RESULTS
  There were no differences in age, sex, weight, body surface area, Acute Physiology and Chronic Health Evaluation II score, fluid replacement, length of operation, blood lost or given, induction temperature, red blood cell or platelet structure, hemolysis, length of intensive care unit or hospital stay, complications, or mortality rates. EVR was associated with increased final core temperature (35.5 degrees +/- 0.8 degrees [EVR] vs 33.8 degrees +/- 0.9 degrees [control]; p < 0.005) and body heat content (-13.9 +/- 62.3 kcal [EVR] vs -118.2 +/- 62.2 kcal [control]; p < 0.01), with heat gained being proportional to flow rate.
  
  
  CONCLUSIONS
  These data show that EVR provides a safe and effective method for the treatment of hypothermia.
authors.affiliation: Department of Surgery, Ohio State University College of Medicine, Columbus 43210.
authors.forename: J S
authors.initials: JS
authors.lastname: Gregory
authors.forename: L
authors.initials: L
authors.lastname: Flancbaum
authors.forename: W L
authors.initials: WL
authors.lastname: Smead
authors.forename: T E
authors.initials: TE
authors.lastname: Reilley
authors.forename: O
authors.initials: O
authors.lastname: Jonasson
mesh_terms: D000368:Aged; D001011:Aorta / Q000601:surgery*; D001831:Body Temperature; D004867:Equipment Design; D004868:Equipment Failure; D006801:Humans; D007035:Hypothermia / Q000503:physiopathology / Q000628:therapy*; D007431:Intraoperative Complications / Q000628:therapy*; D008875:Middle Aged; D011446:Prospective Studies