title: Mitogenic activity and immunological properties of bolesatine, a lectin isolated from the mushroom Boletus satanas Lenz.
abstract: 1. A lectin has been purified from the mushroom Boletus satanas Lenz. 2. The protein, called bolesatine, is mitogenic for human T lymphocytes in a dose- and time-dependent manner. 3. Optimal mitogenic doses induce the release of interleukin-1 alpha and interleukin-2 from mononuclear cell cultures.
authors.affiliation: Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Licastro
authors.forename: M C
authors.initials: MC
authors.lastname: Morini
authors.forename: O
authors.initials: O
authors.lastname: Kretz
authors.forename: G
authors.initials: G
authors.lastname: Dirheimer
authors.forename: E E
authors.initials: EE
authors.lastname: Creppy
authors.forename: F
authors.initials: F
authors.lastname: Stirpe
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D005656:Fungal Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology*; D009183:Mycotoxins; D012756:Sheep; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
chemical_list: D005656:Fungal Proteins; D007375:Interleukin-1; D007376:Interleukin-2; D037102:Lectins; D008934:Mitogens; D009183:Mycotoxins; C060924:Bolesatine protein, Boletus satanas