Effect of lead acetate and carbon particles on the expression of glutathione S-transferase YfYf in rat liver.
Administration of intracardiac lead acetate produces a complex response in glutathione S-transferase (GST) YfYf expression in rat liver. The earliest response, an elevation of GST expression in Kupffer cells, can be mimicked by administering a suspension of carbon particles. The second effect of lead acetate administration is a marked elevation of GST YfYf in some but not all hepatocytes (the 'patchy' response). This effect is most marked 48-76 h after administration of a single dose of lead acetate and is easily detected by immunoblotting. Dexamethasone down-regulates the lead response in hepatocytes.
Boyce
S J
SJ
Department of Biochemistry, Trinity College, Dublin, Ireland.
Mantle
T J
TJ
D000818:Animals; D002244:Carbon / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005982:Glutathione Transferase / Q000096:biosynthesis*; D007527:Isoenzymes / Q000096:biosynthesis* / Q000235:genetics; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007527:Isoenzymes; D009942:Organometallic Compounds; D002244:Carbon; D005982:Glutathione Transferase; C008261:lead acetate