title: [Evaluation of hepatic damage in personnel in the anesthesiology- resuscitation department in relation to halothane exposure].
abstract: In a simple uncontrolled toxicological study 27 workers of an anesthesiology-resuscitation department of a hospital type III were examined. Besides detailed clinical examination, determination of basic hematological and biochemical parameters as well as ultrasonography, also selected parameters of proteosynthetic function of the liver, some so-called proteins of the acute phase and the biological half-life of antipyrine were established in the workers under study. The occurrence of pathological findings in the picture of the examinations performed was related to long-term professional exposure to halothane over the period of one year before the examination. With regard to the possibility of chronic hepatotoxic damage, appropriate attention should be paid to workers of anesthesiology-resuscitation departments, concerning particularly entrance medical examinations and regular screening and follow-up of their health condition, including check-ups hepatic parameters. (Tab. 4, Ref. 23.)
authors.affiliation: Subkatedra klinickej farmakológie ILF v Bratislave, Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Glasa
authors.forename: L
authors.initials: L
authors.lastname: Turecký
authors.forename: J
authors.initials: J
authors.lastname: Holomán
mesh_terms: D000328:Adult; D000776:Anesthesiology; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006282:Health Personnel; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis*; D016273:Occupational Exposure
chemical_list: D006221:Halothane
vernacular_title: Hodnotenie hepatálneho poskodenia u pracovníkov anestéziologicko-resuscitacného oddelenia vzhl'adom na expozíciu halothanu.