Sites of B-cell activation in vivo.
Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites, the periarteriolar lymphoid sheath-associated foci and germinal centers.
Kelsoe
G
G
Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore 21201-1559.
Zheng
B
B
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002455:Cell Division; D006801:Humans; D007114:Immunization; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology