[Effects of NGF on chromaffin adrenaline-containing cells of adrenal medulla of rabbits transplanted into brains of mice].
The graft of chromaffin adrenaline-containing (A) cells of rabbit adrenal medulla implanted to mouse brain and treated with NGF contains more survived cells 1 month after grafting than adrenal medulla alone. The cells developed either an intermediate (e.g. chromaffin cell and neuron) or a neuron-like phenotypes accompanied with a decrease in an immunoreactivity for PNMT (phenyletanolamine-N-methyltransferase). A gap junctions and attached plaques were found between grafted cells. The grafts received a synaptic input. The NGF influence on the fate of chromaffin A-containing cells is discussed.
Jousselin-Hosaja
M
M
Université Pierre-et-Marie-Curie, Département de Neurobiologie des Signaux Intercellulaires, CNRS, Paris, France.
Derbin
C
C
D000313:Adrenal Medulla / Q000166:cytology*; D000818:Animals; D001921:Brain / Q000601:surgery*; D002837:Chromaffin Granules / Q000737:chemistry / Q000187:drug effects / Q000637:transplantation* / Q000648:ultrastructure*; D004837:Epinephrine / Q000032:analysis*; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000494:pharmacology*; D011817:Rabbits
D009414:Nerve Growth Factors; D004837:Epinephrine
Effets du NGF sur les cellules chromaffines à adrénaline de la médullo-surrénale de lapin greffées dans le cerveau de la souris.