Generation of effector cytotoxic T cells from cytotoxic T cell precursors: role of soluble factors.
Cytotoxic T lymphocytes (CTL) have long been recognized as playing a major role in the immune response to alloantigens and viral antigens as well as tumor antigens. The progress of the last decade in the identification and characterization of soluble factors involved in the regulation of the immune response has greatly improved our knowledge of the mechanisms of CTL activation and regulation. This review will summarize the data available in the literature regarding different lymphokines and their specific activity on CTL. In addition it will point out a few of the elements of the systems that hamper its full understanding and it will suggest possible directions for future research.
Palladino
G
G
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104-4268.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006801:Humans; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology* / Q000502:physiology
D008222:Lymphokines