[Expression of left ventricular ANF-gene in rat with cardiac hypertrophy].
Plasma concentration of ANF and expression of left ventricular ANF-gene in rats with cardiac hypertrophy induced by abdominal aortic partial ligation were analyzed by RIA and Northern blot respectively. Results showed that plasma concentration of ANF and level of left ventricular ANF-mRNA in cardiac hypertrophic rats increased markedly, indicating that the cardiac load may induce transcription and expression of left ventricular ANF-gene. This effect could be potentiated by intracellular calcium modulator taurine and inhibited by vasodilator hydralazine.
Xia
L
L
Laboratory of Cardiovascular Molecular Biology and Cardiopulmonary Endocrinology, Beijing Medical University.
Dong
M G
MG
Xu
D L
DL
Yang
H
H
Tang
C S
CS
Tang
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D015152:Blotting, Northern; D006332:Cardiomegaly / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D006973:Hypertension / Q000150:complications; D008297:Male; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic
D012333:RNA, Messenger; D009320:Atrial Natriuretic Factor