Morphometric analysis of the hypoactivity of FSH-immunoreactive cells in estrogen-primed male rats.
In order to evaluate the repercussions of estradiol treatment on the morphology and activity of FSH-producing cells, an immunocytochemical and morphometric study was carried out in male rats treated chronically with estradiol, relating those findings to serum FSH levels at the time of sacrifice. Chronic administration of estradiol led to a decrease (p < 0.01) in serum hormone levels that was accompanied by a marked decrease in cellular size (p < 0.01) due to a decrease in nuclear and cytoplasmic area. Our findings suggest for the adult male rat an inhibitory effect on the synthesis and release of FSH following testicular atrophy induced by treatment with estradiol.
Sánchez
F
F
Department of Human Anatomy and Histology, University of Salamanca.
Carretero
J
J
Rubio
M
M
Riesco
J M
JM
Vázquez
R
R
D000704:Analysis of Variance; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007150:Immunohistochemistry; D008297:Male; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004958:Estradiol; D005640:Follicle Stimulating Hormone