title: A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
abstract: Gerstmann-Sträussler-Scheinker disease in the Indiana kindred is pathologically characterized by prion protein amyloid deposits and neurofibrillary tangles (NFT) with paired helical filaments (PHF). Using antibodies to various domains of the tau molecule, we investigated the composition of PHF in this family by immunocytochemistry and immunoblot analysis. The results indicate that A68 is a component of NFT in this family as it is in Alzheimer's disease, and suggest that post-translational modifications of tau leading to formation of A68 are not unique to Alzheimer's disease.
authors.affiliation: Istituto Neurologico Carlo Besta, Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tagliavini
authors.forename: G
authors.initials: G
authors.lastname: Giaccone
authors.forename: F
authors.initials: F
authors.lastname: Prelli
authors.forename: L
authors.initials: L
authors.lastname: Verga
authors.forename: M
authors.initials: M
authors.lastname: Porro
authors.forename: J Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: M R
authors.initials: MR
authors.lastname: Farlow
authors.forename: B
authors.initials: B
authors.lastname: Frangione
authors.forename: B
authors.initials: B
authors.lastname: Ghetti
authors.forename: O
authors.initials: O
authors.lastname: Bugiani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology* / Q000648:ultrastructure; D016098:Gerstmann-Straussler-Scheinker Disease / Q000235:genetics / Q000473:pathology*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D007196:Indiana; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D016874:Neurofibrillary Tangles / Q000473:pathology* / Q000648:ultrastructure; D016875:tau Proteins
chemical_list: C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D016875:tau Proteins