title: Evaluation of 99Tcm-teboroxime scintigraphy for the differentiation of reversible from fixed defects: comparison with 201T1 redistribution and reinjection imaging.
abstract: The aim of this study was to compare 99Tcm-teboroxime and 201T1 myocardial studies with particular regard to the classification of perfusion defects as reversible or fixed. Twenty patients with a history of previous myocardial infarction and suspected effort ischaemia underwent exercise 201T1 scintigraphy with early (4 h) redistribution and reinjection scans, exercise and rest 99Tcm-teboroxime imaging and coronary angiography. Using a qualitative scoring of static planar images, the perfusion defects were classified as reversible or fixed. 201T1 and 99Tcm-teboroxime gave comparable results in the evaluation of the individual vessels (sensitivity 65%, specificity 80% and 85%, respectively). The stress-redistribution 201T1 sequence classified 45 defects as reversible and 28 as fixed, the stress-rest 99Tcm-teboroxime studies classified 47 as reversible and 26 as fixed (NS). The stress-reinjection 201T1 images, however, characterized 64 defects as reversible and nine as fixed (P < 0.005 versus 201T1 redistribution, P < 0.0005 versus 99Tcm-teboroxime rest). In conclusion, this study shows that rest 99Tcm-teboroxime and 201T1 redistribution give comparable results but that significantly more defects are classified as fixed by 99Tcm-teboroxime than by 201T1 if reinjection of the latter tracer is performed.
authors.affiliation: Department of Clinical Pathophysiology, University of Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bisi
authors.forename: R
authors.initials: R
authors.lastname: Sciagrà
authors.forename: G M
authors.initials: GM
authors.lastname: Santoro
authors.forename: F
authors.initials: F
authors.lastname: Zerauschek
authors.forename: P F
authors.initials: PF
authors.lastname: Fazzini
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015609:Organotechnetium Compounds; D010091:Oximes; D005082:Physical Exertion / Q000502:physiology*; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D013794:Thallium Radioisotopes; C060156:technetium Tc 99m teboroxime