[The anti-arrhythmia action of low-molecular polyvinylpyrrolidone in experimental arrhythmias].
The experiments on 258 albino rats and on 74 albino mice have established that low molecular polyvinylpyrrolidone (PVP) has antiarrhythmic effects. When administered intravenously on a adrenaline model of arrhythmia, PVP and ethmozine showed a very close activity, but PVP resulted in a lower incidence of mortality and proarrhythmia. The action of PVP was weaker than that of ethmozine when they were used in an aconitine model. Oral PVP acted on aconitine-induced arrhythmia stronger and longer than did ethmozine. It is advisable to study the mechanisms of antiarrhythmic activity of PVP.
Mirzaev
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NA
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine; D008297:Male; D051379:Mice; D008970:Molecular Weight; D016293:Moricizine / Q000627:therapeutic use; D011205:Povidone / Q000627:therapeutic use*; D051381:Rats
D000889:Anti-Arrhythmia Agents; D016293:Moricizine; D011205:Povidone; D000157:Aconitine; D004837:Epinephrine
Ob antiaritmicheskom deĭstvii nizkomolekuliarnogo polivinilpirrolidona pri éksperimental'nykh aritmiiakh.