Dermatofibrosarcoma protuberans appearing during pregnancy.
Dermatofibrosarcoma protuberans is an uncommon skin tumor with a high potential for local recurrence if not adequately excised. There are only two reports in the literature describing dermatofibrosarcoma protuberans that enlarged considerably during pregnancy. On the other hand, the new development or enlargement of dermatofibromas in pregnancy is well documented. We present 2 additional patients in whom a dermatofibrosarcoma protuberans appeared and grew rapidly during pregnancy. Immunohistochemical studies were negative for estrogen and progesterone receptors. The possible pathophysiology and surgical management are presented and discussed.
Har-Shai
Y
Y
Department of Plastic and Reconstructive Surgery, Rambam Medical Center, Haifa, Israel.
Govrin-Yehudain
J
J
Ullmann
Y
Y
Kerner
H
H
Cohen
H I
HI
Lichtig
C
C
Bergman
R
R
Cohen
A
A
Kuten
A
A
Friedman-Birnbaum
R
R
D000328:Adult; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008938:Mitosis / Q000502:physiology; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000601:surgery*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone