Dosimetry of iodine-123 iomazenil in humans.
The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq.
Verhoeff
N P
NP
Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
Busemann Sokole
E
E
Hengst
D
D
Stubbs
J B
JB
van Royen
E A
EA
D000328:Adult; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging; D005442:Flumazenil / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011874:Radiometry; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D005442:Flumazenil; C063038:iomazenil