title: Interference screw fixation of cervical grafts. A combined in vitro biomechanical and in vivo animal study.
abstract: The dislodgement of an anterior bone graft in the cervical spine is a frequent complication of attempted fusion following discectomy or corpectomy. It has been hypothesized that fixation augmented with interference screws may increase the pullout strength of the construct and decrease the rate of these complications. In vitro mechanical tests and in vivo sheep studies were conducted to compare interference screw fixation methods for enhancing the fixation between the bone graft and the adjacent vertebra. Using human cadaver cervical spines, the anterior pullout strengths of cervical bone grafts were compared using fixation with and without the addition of interference screws for the in vitro mechanical testing. The mean pullout forces for a Smith-Robinson type bone graft alone was 58.1 N (SD 11.4 N); for the graft augmented with two 3.5 mm cancellous bone screws, 153.9 N (58.9 N); and for the graft with four 3.5 mm screws, 217.1 N (SD 69.9 N). The pullout strengths of the two- and four-3.5 mm screw constructs were significantly greater than the strength of the graft alone (P < 0.05). Similarly placed 2.7 mm cortical screws of the same length provided increased pullout strength (123.7 N 38.6 N and 142.5 N 38.2 N for two- and four-screw constructs, respectively); however, in comparison to the graft alone, these differences were not statistically significant. For both screw types, the four-screw fixations were stronger than the two-screw fixations, although these differences were not statistically significant. For the in vivo portion of the study, a single-level anterior cervical discectomy and fusion were performed on 20 sheep.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Orthopedic Surgery, State University of New York, Health Science Center, Syracuse.
authors.forename: P
authors.initials: P
authors.lastname: Vazquez-Seoane
authors.forename: J
authors.initials: J
authors.lastname: Yoo
authors.forename: D
authors.initials: D
authors.lastname: Zou
authors.forename: L A
authors.initials: LA
authors.lastname: Fay
authors.forename: B E
authors.initials: BE
authors.lastname: Fredrickson
authors.forename: J C
authors.initials: JC
authors.lastname: Handal
authors.forename: H A
authors.initials: HA
authors.lastname: Yuan
authors.forename: W T
authors.initials: WT
authors.lastname: Edwards
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001863:Bone Screws; D016025:Bone Transplantation; D002102:Cadaver; D002574:Cervical Vertebrae / Q000502:physiology / Q000601:surgery*; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D007403:Intervertebral Disc / Q000601:surgery*; D019344:Lactic Acid; D008297:Male; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D012756:Sheep; D013123:Spinal Fusion; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid