[Studies of immunoglobulin surface expression in lymphocytes of peripheral blood, bone marrow and lymph nodes in patients with B-cell chronic lymphocytic leukemia].
The expression of surface immunoglobulins (SIg) on peripheral blood, bone marrow, and lymph node lymphocytes was studied in a group of 10 patients with B cell chronic lymphocytic leukaemia. In 4 patients differences in the SIg phenotypes were found when cells from blood, bone marrow and lymph nodes were examined. Peripheral blood lymphocytes were characterized as a monoclonal B cell population whereas in the marrow or lymph node lymphocytes a tendency toward poly-clonality was found. We suggest that these differences reflect the origin of the initial leukaemic transformation: intra versus extra-medullar. In case of intramedullary origin of leukaemia the transformed clone infiltrates subsequently lymph nodes or other lymphoid structures. In leukaemia of extra-medullar origin the bone marrow is infiltrated later and therefore the tendency toward polyclonal SIg picture of the bone marrow lymphocytes contrasts with the monoclonality of the peripheral blood cells.
Rupniewska
Z
Z
Kliniki Hematologii AM w Lublinie.
Wach
M
M
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*
D011947:Receptors, Antigen, B-Cell
Badania powierzchniowych immunoglobulin limfocytów krwi obwodowej, szpiku i wezła chłonnego chorych z przewlekła białaczka limfatyczna B komórkowa.