title: Falling intracranial pressure: an important element in the genesis of intracranial hemorrhage in the beagle puppy.
abstract: To study the role of extravascular intracranial pressure (ICP) in the genesis of intracranial hemorrhage in the beagle puppy, we measured ICP in animals on the day of birth, untreated 3-day-old controls, and 3-day-old animals treated from birth with prolactin. Baseline ICP varied substantially in all 3 groups. Only 8% of this variability was attributable to variability in mean arterial pressure and central venous pressure. ICP was lower in the 3-day-old controls, animals at high risk for intracranial hemorrhage after a hypovolemic/hypotensive insult followed by rapid volume expansion, than in the other groups which are at lower risk. Administration of a hyperosmolar insult, intraperitoneal glycerol, to animals whose ICP was relatively high promptly lowered ICP. After this treatment, the risk of intracranial hemorrhage was markedly increased in these previously low-risk groups. We conclude that the normal neonatal decrease in brain water content and the consequent fall in ICP substantially increase the risk of intracranial hemorrhage in the beagle puppy, a model which appears similar in pathophysiology to hemorrhage in the preterm human infant.
authors.affiliation: Department of Pediatrics and Pathology, University of Utah School of Medicine, Salt Lake City.
authors.forename: D M
authors.initials: DM
authors.lastname: Coulter
authors.forename: W M
authors.initials: WM
authors.lastname: Gooch
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001826:Body Fluids / Q000502:physiology; D001921:Brain / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007427:Intracranial Pressure / Q000502:physiology*; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology
chemical_list: D011388:Prolactin; D005990:Glycerol