title: Suppression of DNA synthesis and induction of apoptosis in rat prostate by human seminal plasma inhibin (HSPI).
abstract: In vivo administration of HSPI (10.7 kDa FSH suppressing peptide of prostate) to intact adult male rats was found to suppress the basal levels of incorporation of 3H-thymidine into DNA of ventral and dorsolateral lobes of the prostate, in a dose-dependent manner. Interestingly, microscopic examination of the prostate histology of HSPI treated rats revealed a significantly increased incidence of apoptotic bodies which are indicative of cell death. In another experiment, HSPI was also found to suppress the active DNA synthesis in testosterone-induced regrowth of prostate in castrated rats. Thus HSPI can suppress the basal and stimulated DNA synthesis and also induce apoptotic cell death in rat prostate.
authors.affiliation: Endocrinology Unit, Tata Memorial Centre, Parel, Bombay, India.
authors.forename: S D
authors.initials: SD
authors.lastname: Mundle
authors.forename: N A
authors.initials: NA
authors.lastname: Sheth
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007265:Inhibins / Q000097:blood / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009919:Orchiectomy; D011467:Prostate / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012661:Semen / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D013739:Testosterone; D007265:Inhibins; D004247:DNA