title: Use of tissue plasminogen activator for reopening of clotted dialysis catheters.
abstract: The use of central venous catheters as permanent vascular access in chronic hemodialysis is complicated by clotting. We have tried a nonallergenic thrombolytic agent, tissue plasminogen activator (t-PA), to dissolve catheter luminal thrombosis. Eight patients, 7 in chronic hemodialysis and 1 treated by immune adsorption had 18 treatments with locally applied t-PA (2 mg/2 cm3). Fifteen out of 16 treatments with longer bolus dwell than 60 min were successful. No side effects occurred. t-PA dissolves clot formation efficiently and safely, the drug is nonallergenic and can therefore be given repeatedly.
authors.affiliation: Medical Department B, National Hospital of Norway, Oslo.
authors.forename: D
authors.initials: D
authors.lastname: Paulsen
authors.forename: A
authors.initials: A
authors.lastname: Reisoether
authors.forename: M
authors.initials: M
authors.lastname: Aasen
authors.forename: P
authors.initials: P
authors.lastname: Fauchald
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects; D002405:Catheterization, Central Venous; D006801:Humans; D006435:Renal Dialysis; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator