title: Regulation by Ca2+ in the Yersinia low-Ca2+ response.
abstract: The Yersinia low-Ca2+ response (LCR) is a regulatory response in which a set of plasmid-borne operons is transcriptionally regulated at 37 degrees C in response to the presence or absence of mM concentrations of Ca2+. LCR-regulated operons encode secreted proteins with regulatory and virulence roles as well as non-secreted regulatory proteins and components of the secretion machinery. Downregulation by Ca2+ is imposed by a signalling cascade that includes secreted proteins and possibly also components of the secretion system and is hypothesized to act on membrane-bound inductive components. An important role in LCR induction is played by LcrD, an inner-membrane protein with homologues in several virulence-associated and flagella assembly-related systems in diverse bacterial species. The mechanism of signal transduction in response to Ca2+ is not known, and the proteins that bind DNA to downregulate transcription have not been identified.
authors.affiliation: Department of Microbiology and Immunology, University of Kentucky, Lexington 40536-0084.
authors.forename: S C
authors.initials: SC
authors.lastname: Straley
authors.forename: G V
authors.initials: GV
authors.lastname: Plano
authors.forename: E
authors.initials: E
authors.lastname: Skrzypek
authors.forename: P L
authors.initials: PL
authors.lastname: Haddix
authors.forename: K A
authors.initials: KA
authors.lastname: Fields
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D002118:Calcium / Q000502:physiology*; D005798:Genes, Bacterial; D009876:Operon; D010641:Phenotype; D010957:Plasmids / Q000235:genetics; D015398:Signal Transduction; D014774:Virulence / Q000235:genetics; D015007:Yersinia / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D002118:Calcium