title: Phosphatidylserine in the outer leaflet of red blood cells from beta-thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes.
abstract: Investigation of red blood cells from beta-thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life-long platelet activation that are found in thalassemic patients.
authors.affiliation: Department of Membrane Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
authors.forename: V
authors.initials: V
authors.lastname: Borenstain-Ben Yashar
authors.forename: Y
authors.initials: Y
authors.lastname: Barenholz
authors.forename: E
authors.initials: E
authors.lastname: Hy-Am
authors.forename: E A
authors.initials: EA
authors.lastname: Rachmilewitz
authors.forename: A
authors.initials: A
authors.lastname: Eldor
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000648:ultrastructure; D004912:Erythrocytes / Q000737:chemistry* / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008264:Macrophages / Q000502:physiology; D010587:Phagocytosis / Q000502:physiology; D010718:Phosphatidylserines / Q000032:analysis* / Q000502:physiology; D015539:Platelet Activation / Q000502:physiology; D013927:Thrombosis / Q000097:blood / Q000209:etiology*; D017086:beta-Thalassemia / Q000097:blood*
chemical_list: D010718:Phosphatidylserines