Hepatotoxic effects in a child receiving valproate and carnitine.
L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid. We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.
Murphy
J V
JV
Neurology Section, Children's Mercy Hospital, Kansas City, Missouri 64108.
Groover
R V
RV
Hodge
C
C
D002331:Carnitine / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D017211:Treatment Failure; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D014635:Valproic Acid; D002331:Carnitine