title: Disseminated skeletal tuberculosis with skull involvement.
abstract: We report a patient with widespread osteolytic lesions, including extensive involvement of the skull, due to Mycobacterium tuberculosis. Response to treatment with antituberculosis drugs was slow with appearance of new lesions while on therapy despite a sensitive organism. Excision of diseased skull bone was eventually done, after which no new lesions appeared in the ensuing 14 months.
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong.
authors.forename: M
authors.initials: M
authors.lastname: Ip
authors.forename: E
authors.initials: E
authors.lastname: Tsui
authors.forename: K L
authors.initials: KL
authors.lastname: Wong
authors.forename: B
authors.initials: B
authors.lastname: Jones
authors.forename: C F
authors.initials: CF
authors.lastname: Pung
authors.forename: H
authors.initials: H
authors.lastname: Ngan
mesh_terms: D000293:Adolescent; D000921:Antibody-Producing Cells / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D012886:Skull / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D014394:Tuberculosis, Osteoarticular / Q000000981:diagnostic imaging* / Q000276:immunology / Q000628:therapy