Lys- and Leu-aminopeptidase activity after acute toluene exposure in the rat brain.
Changes in Lys- and Leu-aminopeptidase activities in several brain regions of the rat, after acute toluene administration, are described in this research. Aminopeptidase activity has been suggested as a candidate regulator of the degradation of several neuroactive peptides. Lys-aminopeptidase activity was significantly decreased in the thalamus, amygdala, and medulla oblongata. Leu-aminopeptidase activity was significantly decreased in the thalamus and cerebellum. It is suggested that these aminopeptidase activities could play a part in the mechanism of toluene neurotoxicity.
De Gandarias
J M
JM
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Echevarria
E
E
Irazusta
J
J
Casis
E
E
Casis
L
L
D000626:Aminopeptidases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D007931:Leucyl Aminopeptidase / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014050:Toluene / Q000633:toxicity*
D014050:Toluene; D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; C056860:lysyl aminopeptidase