Effect of alkyldimethylamine oxides on anaerobic sporulating bacteria of genus Clostridium.
Antibacterial activity of alkyldimethylamine oxides and Iodaminox was determined in vitro in 11 strains of clostridia. The most efficient was (1-methyldodecyl)dimethylamine oxide (MIC = 7.8-78 mumol/L). Iodaminox was about twice as efficient (MIC = 3.9-31 mumol/L). The bactericidal activity of both compounds was tested at different periods of exposure, ambient pH and cultivation temperature on three species of clostridia. The activity of both compounds was the highest at pH 6 and 40 degrees C.
Cigáneková
V
V
Department of Microbiology and Virology, Faculty of Science, Comenius University, Bratislava, Slovakia.
Kallová
J
J
D000693:Anaerobiosis; D003013:Clostridium / Q000187:drug effects* / Q000502:physiology; D004123:Dimethylamines / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D007466:Iodophors / Q000494:pharmacology; D010087:Oxides / Q000494:pharmacology*; D013171:Spores, Bacterial
D004123:Dimethylamines; D004202:Disinfectants; D007466:Iodophors; D010087:Oxides; C052699:iodaminox