Increased serum level of interleukin-5 in a patient with episodic angioedema and eosinophilia syndrome.
A case of episodic angioedema and eosinophilia syndrome is reported. An 18-year-old male suffered from monthly episodes of angioedema, pruritic papules, weight gain, and fever for twelve years. During the episodes, peripheral eosinophils and serum levels of interleukin (IL)-5, an eosinophil proliferating cytokine were elevated. Extensive evaluations disclosed neither visceral involvement nor evidence of parasitic infections, collagen diseases, or neoplastic disorders. Corticosteroid treatment brought about a dramatic clinical improvement concomitant with decrement of eosinophils and serum IL-5 was observed. These observations suggest that IL-5 may be a causative factor for this pathological state.
Murakami
T
T
Department of Internal Medicine (Section 4), Sapporo Medical College, Japan.
Kato
J
J
Kogawa
K
K
Watanabe
N
N
Sakamaki
S
S
Kohgo
Y
Y
Hamabe
K
K
Ishiyama
N
N
Enokihara
H
H
Niitsu
Y
Y
D000293:Adolescent; D000799:Angioedema / Q000276:immunology*; D004802:Eosinophilia / Q000276:immunology*; D006801:Humans; D015848:Interleukin-5 / Q000097:blood*; D008297:Male; D012008:Recurrence; D013577:Syndrome
D015848:Interleukin-5