title: T cell mediated immunosuppression.
abstract: Suppressor T cells down-regulate the activity of other cells in the immune system, and, albeit controversial, are believed to play a role in immunological tolerance and immunoregulation. Significant progress has been made in characterizing suppressor T cells and their receptors, and in elucidating mechanisms of immunosuppression. This knowledge is important for understanding the immune system and certain disease states and for favorably manipulating immunity.
authors.affiliation: Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany.
authors.forename: D B
authors.initials: DB
authors.lastname: Murphy
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D017209:Apoptosis; D015551:Autoimmunity; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007108:Immune Tolerance; D016219:Immunotherapy, Adoptive; D008954:Models, Biological; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013491:Suppressor Factors, Immunologic