title: Intracavernous sodium nitroprusside: inappropriate impotence treatment.
abstract: On the basis of reports describing nitric oxide as a form of endothelium-derived relaxing factor and on our own experience with intracavernous use of nitric oxide-releasing substances in animal models, we undertook an approved human study of intracavernous sodium nitroprusside as a treatment for impotence. We report our early experience in which severe hypotension and only mild tumescence in our first 3 patients caused us to discontinue the trial.
authors.affiliation: Department of Urology, University of California Medical School, San Francisco 94143-0738.
authors.forename: G
authors.initials: G
authors.lastname: Brock
authors.forename: J
authors.initials: J
authors.lastname: Breza
authors.forename: T F
authors.initials: TF
authors.lastname: Lue
mesh_terms: D000368:Aged; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007267:Injections / Q000379:methods; D008297:Male; D009599:Nitroprusside / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010413:Penis; D017211:Treatment Failure
chemical_list: D009599:Nitroprusside