Erythropoietin as a mitogen for fetal liver stromal cells which support erythropoiesis.
Fetal liver stromal cells established from 13-day-old embryos support erythropoiesis in vitro in combination with erythropoietin (Epo). Epo stimulated growth of these stromal cells in a dose-dependent manner and mRNA for Epo receptor was detected. These results suggest the possible involvement of Epo in the generation of the fetal erythropoietic microenvironment during development.
Ohneda
O
O
Department of Cell Biology, Tohoku University, Sendai, Japan.
Yanai
N
N
Obinata
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004920:Erythropoiesis; D004921:Erythropoietin / Q000235:genetics / Q000494:pharmacology*; D015870:Gene Expression; D008099:Liver / Q000166:cytology / Q000196:embryology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens; D012333:RNA, Messenger / Q000235:genetics
D008934:Mitogens; D012333:RNA, Messenger; D004921:Erythropoietin