Effect of continuous arteriovenous haemofiltration on pharmacokinetics of amrinone.
This case report details the pharmacokinetic adjustments of an amrinone infusion in a paediatric patient who developed multiorgan system failure with anuric renal failure and was prescribed continuous arteriovenous haemofiltration. A significant proportion of clearance of amrinone is nonrenal. Near normal amrinone clearance can occur in patients with hepatic and renal dysfunction if continuous arteriovenous haemofiltration is used. Hepatic dysfunction with renal failure may require a reduction in the continuous amrinone infusion rate as previously reported for neonates.
Lawless
S
S
Department of Pediatric Anesthesia/Critical Care, Alfred I. duPont Institute, Wilmington, Delaware.
Restaino
I
I
Azin
S
S
Corddry
D
D
D058186:Acute Kidney Injury / Q000150:complications / Q000628:therapy; D000676:Amrinone / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D005260:Female; D006207:Half-Life; D006440:Hemofiltration; D006801:Humans; D008657:Metabolic Clearance Rate; D009102:Multiple Organ Failure / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D006435:Renal Dialysis
D000676:Amrinone