title: [Primary hyperreninemia. An unusual cause of secondary arterial hypertension].
abstract: In 1975, scintigraphy revealed a 6.5 x 5 cm tumour in the region of the left adrenal in a 36-year-old man with known hypertension for 5 years (systolic pressure up to 250 mm Hg, diastolic up to 130 mm Hg). A laparotomy was performed for a suspected phaeochromocytoma. A tumour was located in the upper pole of the kidney and removed together with the kidney. The blood pressure quickly returned to normal after the operation: it remained stable for the following 17 years (between 130/80 to 150/90 mm Hg). Originally the tumour could not be clearly classified either clinically or histologically. But recently the paraffin-imbedded tumour specimen was re-examined by immunohistochemistry and in-situ hybridization. This identified a renin-producing tumour so that primary reninism was the cause of the arterial hypertension.
authors.affiliation: Innere Abteilung, Universität Bonn.
authors.forename: R
authors.initials: R
authors.lastname: Kreutz
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: U
authors.initials: U
authors.lastname: Pfeifer
authors.forename: J M
authors.initials: JM
authors.lastname: Gasc
authors.forename: D
authors.initials: D
authors.lastname: Ganten
authors.forename: F J
authors.initials: FJ
authors.lastname: Kessler
mesh_terms: D000328:Adult; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology*; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D012083:Renin / Q000378:metabolism*
chemical_list: D012083:Renin
vernacular_title: Primärer Hyperreninismus. Eine seltene Ursache der sekundären arteriellen Hypertonie.