title: An outbreak of pellagra related to changes in dietary niacin among Mozambican refugees in Malawi.
abstract: Between February and October 1990, 18,276 cases of pellagra dermatitis (due to niacin deficiency) were reported among 285,942 Mozambican refugees in Malawi. Overall, 6.3% of the refugee population developed pellagra and the attack rate was 7.8 times higher among women than men. This outbreak followed a 5-month cessation of groundnut distribution (the major source of niacin) to refugees. A matched-pair case-control study confirmed the protective role of the daily consumption of groundnuts (Odds Ratio [OR] = 0.08), as well as the independent role of garden ownership (OR = 0.34), and home maize milling (OR = 0.3). Recommended corrective action included early case finding and treatment, distribution of niacin tablets, prompt identification of groundnut supply on the world market, fortification with niacin of the food ration and diversification of the food basket through access to local markets.
authors.affiliation: Institut National d'Agronomie, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Malfait
authors.forename: A
authors.initials: A
authors.lastname: Moren
authors.forename: J C
authors.initials: JC
authors.lastname: Dillon
authors.forename: A
authors.initials: A
authors.lastname: Brodel
authors.forename: G
authors.initials: G
authors.lastname: Begkoyian
authors.forename: M G
authors.initials: MG
authors.lastname: Etchegorry
authors.forename: G
authors.initials: G
authors.lastname: Malenga
authors.forename: P
authors.initials: P
authors.lastname: Hakewill
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004032:Diet / Q000009:adverse effects*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D008297:Male; D009073:Mozambique / Q000208:ethnology; D009525:Niacin / Q000172:deficiency*; D010383:Pellagra / Q000453:epidemiology* / Q000209:etiology*; D012036:Refugees
chemical_list: D009525:Niacin