Naltrexone treatment attenuates the inhibitory effect of nicotine treatment on serum LH in rats.
The hypothesis that endogenous opioids might have a role in mediating the suppressive effects of nicotine on serum LH concentrations in rats was investigated. Naltrexone treatment prevented the inhibitory effect of high doses of nicotine on serum LH concentrations. Nicotine treatment also prevented the stimulatory effect of naltrexone on serum LH concentrations. These results suggest that the inhibitory effects of nicotine on serum LH concentrations involve an opioidergic component.
Hodson
C A
CA
Department of Obstetrics and Gynecology, East Carolina University School of Medicine, Greenville, North Carolina 27858.
Davenport
A
A
Price
G
G
Burden
H W
HW
D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004359:Drug Therapy, Combination; D007986:Luteinizing Hormone / Q000097:blood* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009271:Naltrexone / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009271:Naltrexone; D009538:Nicotine; D003907:Dexamethasone; D007986:Luteinizing Hormone