[Distribution of cofactor-dependent anti-cardiolipin antibodies in collagen diseases].
Cofactor-dependent IgG anti-cardiolipin antibodies (ACA) were examined in sera from various connective tissue diseases by ELISA using purified human beta 2-glycoprotein I. The frequency and titer of cofactor-dependent IgG ACA were higher in patients with SLE than in those with other diseases, such as RA, SSc, PM/DM, overlap syndrome, and MCTD. The predictive value for SLE was 95%. However, all of the ACA were not cofactor-dependent in SLE patients. These results indicated that cofactor-dependent IgG ACA were specific for SLE patients, but the epitopes of ACA were heterogenous, depending on various clinical manifestations.
Yamamoto
M
M
Laboratory Medicine, Keio University School of Medicine.
Kaburaki
J
J
Kuwana
M
M
Kawai
S
S
Matsuura
E
E
Ikeda
Y
Y
D017153:Antibodies, Anticardiolipin / Q000378:metabolism*; D003095:Collagen Diseases / Q000276:immunology*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D011237:Predictive Value of Tests; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D006023:Glycoproteins; D007074:Immunoglobulin G; D053482:beta 2-Glycoprotein I