title: Drug and alcohol use and neuropsychological performance in asymptomatic HIV infection.
abstract: The effect of drug and alcohol abuse on neuropsychological performance was examined in 132 human immunodeficiency virus-seropositive gay or bisexual men. Syndromal (diagnostic) criteria of alcohol/drug abuse based on DSM-III-R were used, and quantitative estimates of alcohol consumption were obtained. Very few differences appeared between substance abuse subgroups formed on the basis of recency or severity of drug use. There were some correlations with the quantitative estimate of alcohol use, but not on the measures previously found to differentiate seronegative and asymptomatic seropositive gay men. These data indicate that alcohol use does affect neuropsychological performance but does not account for the differences observed in studies of seronegative and seropositive subjects.
authors.affiliation: Department of Psychiatry, Ohio State University, Columbus 43210.
authors.forename: R A
authors.initials: RA
authors.lastname: Bornstein
authors.forename: R
authors.initials: R
authors.lastname: Fama
authors.forename: P
authors.initials: P
authors.lastname: Rosenberger
authors.forename: C C
authors.initials: CC
authors.lastname: Whitacre
authors.forename: M F
authors.initials: MF
authors.lastname: Para
authors.forename: H A
authors.initials: HA
authors.lastname: Nasrallah
authors.forename: R J
authors.initials: RJ
authors.lastname: Fass
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D006679:HIV Seropositivity / Q000097:blood* / Q000150:complications; D006716:Homosexuality; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000175:diagnosis; D009483:Neuropsychological Tests; D011930:Reaction Time; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications / Q000175:diagnosis* / Q000523:psychology