15-Deoxyspergualin, a novel immunosuppressive drug: studies of the mechanism of action.
Tepper
M A
MA
Department of Immunology, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492.
Nadler
S
S
Mazzucco
C
C
Singh
C
C
Kelley
S L
SL
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D015375:Receptors, Interleukin-2 / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects
D006146:Guanidines; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D016572:Cyclosporine; C037258:gusperimus