A microsatellite-based index map of human chromosome 11.
We have constructed a continuous index map of 25 microsatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygosities of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 10(5):1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the index map with the cytogenetic map. The map will facilitate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.
Litt
M
M
Oregon Health Sciences University, Portland 97201.
Kramer
P
P
Hauge
X Y
XY
Weber
J L
JL
Wang
Z
Z
Wilkie
P J
PJ
Holt
M S
MS
Mishra
S
S
Donis-Keller
H
H
Warnich
L
L
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004276:DNA, Satellite / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D004276:DNA, Satellite; D005819:Genetic Markers