Cytotoxic sesquiterpenes from Nardostachys chinensis.
Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.
Itokawa
H
H
Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
Masuyama
K
K
Morita
H
H
Takeya
K
K
D000818:Animals; D016923:Cell Death / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D012717:Sesquiterpenes