[Effect of nylestriol on postmenopausal uterine endometrium].
Curettage was performed in 139 postmenopausal women before as well as 6 months, 12 months and 36 months after Nylestiol (CEE3) therapy, for totally 205 times. It was found that CEE3 could induce endometrial proliferation and uterine breakthrough bleeding, much greater in women using 2 mg of CEE3 than in those using 1 mg. Ciliated cell were present in the proliferative endometrium after CEE3. The endometrial tissues obtained in curettage in women after 12 months' therapy was similar to that of 6 months' therapy. No more endometrium was obtained after 36 months' therapy. Provera were given for women who had proliferative endometrium after 6-12 months' therapy with CEE3 1-2 mg/2w. There were no changes of endometrium. This suggested that further study the interval and dosage of provera should be given with CEE3.
Liu
J L
JL
General Hospital of Chinese PLA, Beijing.
D000368:Aged; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D008593:Menopause; D008875:Middle Aged; D011800:Quinestrol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014592:Uterine Hemorrhage / Q000139:chemically induced
C010722:nylestriol; D017258:Medroxyprogesterone Acetate; D011800:Quinestrol