title: [The influence of indoor environmental factors on the onset of allergic disease].
abstract: To predict and prevent the onset of allergic diseases, we studied the effects of indoor environmental factors, such as diet, on pregnant women and carried out follow-up studies on their infants. Blood samples were collected at random from women who were diagnosed as pregnant (n = 2045). Umbilical cord blood was collected at delivery (n = 1453). To evaluate the efficacy of food guidance, the pregnant women were divided into two groups--one receiving simple diet guidance starting in the later stages of pregnancy, and one receiving no guidance whatsoever. A follow-up survey on allergic symptoms was done on their two-year-old infants, revealing a lower incidence of symptomatic manifestations in the diet guidance group (p < 0.001). Respiratory symptoms (p < 0.05) were associated with maternal smoking and outside work during pregnancy. A study on food guidance in combination with environmental factors revealed that the incidence of respiratory symptoms in two-year-old infants whose mothers received diet guidance in a good indoor environment was held down to around 36.1%, while the incidence in infants whose mothers received diet guidance in a poor indoor environment was 48.1%.
authors.affiliation: Division of Allergy, National Children's Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Akimoto
authors.forename: A
authors.initials: A
authors.lastname: Akasawa
authors.forename: H
authors.initials: H
authors.lastname: Chiba
authors.forename: Y
authors.initials: Y
authors.lastname: Iikura
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects*; D002675:Child, Preschool; D004032:Diet; D005260:Female; D006798:Housing; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000517:prevention & control; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D011247:Pregnancy; D012307:Risk Factors