Chronic methanesulfonyl fluoride enhances one-trial per day reward learning in aged rats.
Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly greater speed and accuracy on a 1 trial/day discriminative reward learning task. The chronic MSF treatment resulted in a 56% decrease in brain AChE activity but no discernable locomotor side effects and no liver damage as indicated by aspartate transferase activity.
Malin
D H
DH
University of Houston-Clear Lake, TX 77058.
Plotner
R E
RE
Radulescu
S J
SJ
Ferebee
R N
RN
Lake
J R
JR
Negrete
P G
PG
Schaefer
P J
PJ
Crothers
M K
MK
Moss
D E
DE
D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000523:psychology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D004193:Discrimination Learning / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012201:Reward; D013450:Sulfones / Q000494:pharmacology* / Q000633:toxicity
D002800:Cholinesterase Inhibitors; D013450:Sulfones; C005109:methanesulfonyl fluoride; D001219:Aspartate Aminotransferases; D000110:Acetylcholinesterase