title: Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels.
abstract: Groups of 122 Peruvian adults of low socioeconomic level (SEL) and 125 of high SEL received a randomly allocated 5 x 10(9)- or 5 x 10(8)-CFU dose of CVD 103-HgR live oral cholera vaccine or a placebo. The vaccine was well tolerated. Vibriocidal seroconversions occurred in 78% of high-SEL and 72% of low-SEL subjects who ingested the high dose and in 78 and 49%, respectively, of those who received the low dose.
authors.affiliation: Instituto de Medicina Tropical, Universidad Peruana Cayetano Heredia, Lima.
authors.forename: E
authors.initials: E
authors.lastname: Gotuzzo
authors.forename: B
authors.initials: B
authors.lastname: Butron
authors.forename: C
authors.initials: C
authors.lastname: Seas
authors.forename: M
authors.initials: M
authors.lastname: Penny
authors.forename: R
authors.initials: R
authors.lastname: Ruiz
authors.forename: G
authors.initials: G
authors.lastname: Losonsky
authors.forename: C F
authors.initials: CF
authors.lastname: Lanata
authors.forename: S S
authors.initials: SS
authors.lastname: Wasserman
authors.forename: E
authors.initials: E
authors.lastname: Salazar
authors.forename: J B
authors.initials: JB
authors.lastname: Kaper
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D004311:Double-Blind Method; D006801:Humans; D010568:Peru; D012959:Socioeconomic Factors; D014611:Vaccination; D014734:Vibrio cholerae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines