title: Fibrinogen and fibrin derivatives in traumatized patients: relation to injury severity and posttraumatic pulmonary dysfunction.
abstract: In a prospective study including 30 traumatized patients, levels of fibrinogen, fibrinopeptide A (FpA), fibrin monomers (FM) and fibrin degradation products (FbDP) were measured on admission and on days 1, 2, 3 and 7 after the incident. High levels of FpA, FM and FbDP were observed immediately after the trauma. Fibrinogen levels increased during the first 7 posttraumatic days whereas FpA and FM decreased. FbDP was significantly higher on day 7 than on day 3. All variables were to some extent correlated to the injury severity score. FbDP were significantly lower on the day after admission in 4 patients who developed pulmonary dysfunction compared with patients without this complication.
authors.affiliation: Department of Orthopedics, Aalborg Hospital, Denmark.
authors.forename: J V
authors.initials: JV
authors.lastname: Sørensen
authors.forename: H P
authors.initials: HP
authors.lastname: Jensen
authors.forename: H B
authors.initials: HB
authors.lastname: Rahr
authors.forename: L C
authors.initials: LC
authors.lastname: Borris
authors.forename: M R
authors.initials: MR
authors.lastname: Lassen
authors.forename: O
authors.initials: O
authors.lastname: Fedders
authors.forename: J P
authors.initials: JP
authors.lastname: Haase
authors.forename: F
authors.initials: F
authors.lastname: Knudsen
mesh_terms: D000293:Adolescent; D000328:Adult; D006259:Craniocerebral Trauma / Q000097:blood* / Q000150:complications; D005260:Female; D005337:Fibrin / Q000032:analysis*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005340:Fibrinogen / Q000032:analysis*; D005342:Fibrinolysis; D005344:Fibrinopeptide A / Q000032:analysis*; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood* / Q000150:complications; D011446:Prospective Studies; D011654:Pulmonary Edema / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005344:Fibrinopeptide A; D005337:Fibrin; D005340:Fibrinogen