title: Hypersensitivity to heparin; a case report.
abstract: Hypersensitivity reactions to heparin are very rare. A generalized hypersensitivity reaction including as fever and skin rash to a porcine- and bovine-derived heparin preparation was observed in a hemodialysis patient due to the nephrotic syndrome. The patient revealed peripheral eosinophilia and normal serum IgE. The results of a drug lymphocyte stimulating test on heparin were positive. Following prednisolone administration and infusion of nafamostat mesilate as anticoagulant therapy during hemodialysis, the high fever and generalized urticaria disappeared. Caution is required when conducting heparin therapy on hemodialysis patients.
authors.affiliation: Department of Internal Medicine, Murakami Memorial Hospital, Asahi University, Gifu, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Katoh
authors.forename: S
authors.initials: S
authors.lastname: Terashima
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahara
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Tatsukawa
authors.forename: K
authors.initials: K
authors.lastname: Ida
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D000368:Aged; D004342:Drug Hypersensitivity / Q000209:etiology*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D006435:Renal Dialysis
chemical_list: D006493:Heparin