title: Cytogenetic changes in 67 cranial and spinal meningiomas: relation to histopathological and clinical pattern.
abstract: The cytogenetic analysis of 67 meningiomas (58 intracranial and 9 spinal tumors) identified chromosomal abnormalities in 63% of cases. When chromosomes involved in numerical and structural changes with a frequency of more than one standard deviation above the mean were considered, distinct cytogenetic patterns could be identified according to sex, anatomical location and histology. The chromosomes more frequently affected were 1, 2, 3, 4, 8, 14, 15, 19, 22, Y. No conclusion could be drawn regarding the prognostic significance of these karyotypic alterations.
authors.affiliation: Laboratory of Cytogenetics, Maison Blanche Hospital, Reims, France.
authors.forename: M
authors.initials: M
authors.lastname: Doco-Fenzy
authors.forename: P
authors.initials: P
authors.lastname: Cornillet
authors.forename: B
authors.initials: B
authors.lastname: Scherpereel
authors.forename: B
authors.initials: B
authors.lastname: Depernet
authors.forename: S
authors.initials: S
authors.lastname: Bisiau-Leconte
authors.forename: D
authors.initials: D
authors.lastname: Ferre
authors.forename: M
authors.initials: M
authors.lastname: Pluot
authors.forename: J P
authors.initials: JP
authors.lastname: Graftiaux
authors.forename: J R
authors.initials: JR
authors.lastname: Teyssier
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D012737:Sex Factors; D013120:Spinal Cord Neoplasms / Q000235:genetics* / Q000473:pathology; D014407:Tumor Cells, Cultured