Aggressive drug therapy for rheumatoid arthritis.
Recent data indicate that rheumatoid arthritis is more often systemic, progressive, and disabling than benign, and that it reduces life expectancy. The new evidence argues for a dramatic alteration in pharmacologic management. If several months of rest, exercise, and anti-inflammatory therapy are ineffectual, aggressive treatment with disease-modifying antirheumatic and immunosuppressive agents may be in order.
McGuire
J L
JL
Stanford University School of Medicine.
Ridgway
W M
WM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006046:Gold / Q000009:adverse effects; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D013601:T-Lymphocytes / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006046:Gold; D008727:Methotrexate