[Cyclic ureas. 2. Racemates and enantiomers of imidazolidin-2-ones: synthesis, configuration and sedative-hypnotic action].
The racemates and the enantiomers of the imidazolidin-2-ones 2a and 2b, which can be considered as cyclic ureas, are obtained from the racemates and the enantiomers of the hydantoins 1a and 1b by reduction with LiAlH4/AlCl3. The enantiomers that are dextrorotating in ethanol possess S-configuration. In a study with Wistar-rats, 2a and 2b show sedative-hypnotic activity. The enantiomers exhibit marked enantioselective differences in their potency.
Knabe
J
J
Fachrichtung Pharmazeutische Chemie, Universität des Saarlandes.
Büch
H P
HP
Biwersi
J
J
D000818:Animals; D005260:Female; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008968:Molecular Conformation; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
D006993:Hypnotics and Sedatives; D007093:Imidazoles
Racemate und Enantiomere von Imidazolidin-2-onen Synthese, Konfiguration und sedativ-hypnotische Wirkung.