Genetics of cancer predisposition and progression.
The development of human cancer is a multistep process that entails a progressively more malignant phenotype through the evolution of cellular subsets with increasing numbers of genetic alterations. Here we review the molecular genetics of human cancer predisposition and progression and describe paradigmatic cancer types and cancer syndromes. We also briefly consider the future impact of molecular biology on cancer diagnosis and treatment.
Schwechheimer
K
K
Ludwig Institute for Cancer Research, San Diego Branch, La Jolla.
Cavenee
W K
WK
D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D005799:Genes, Dominant; D005808:Genes, Recessive; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D009857:Oncogenes; D011519:Proto-Oncogenes; D017384:Sequence Deletion