CD33, CD4-double positive blastic transformation in a patient with chronic myelogenous leukemia.
We report a 19-year-old female with blastic transformation of chronic myelogenous leukemia whose blasts had CD33 and CD4 phenotypes, although no significant characteristics were detected by morphological and histochemical analysis. In a colony assay with hematopoietic growth factors, the blasts proliferated and differentiated into myelo-monocytic lineage, particularly in the presence of GM-CSF or IL-3 + G-CSF. The blasts transformed from CML were assumed to be myelo-monocytic progenitor cells, corresponding to GM colonies. Blastic transformation expressing such a phenotype has not been reported previously.
Hirayama
Y
Y
Department of Internal Medicine (Section 4), Sapporo Medical College, Japan.
Kohgo
Y
Y
Kanisawa
Y
Y
Fujii
S
S
Ikeda
K
K
Matsunaga
T
T
Ito
Y
Y
Sakamaki
S
S
Niitsu
Y
Y
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D001752:Blast Crisis / Q000276:immunology* / Q000473:pathology; D015704:CD4 Antigens / Q000032:analysis*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology* / Q000473:pathology; D063268:Sialic Acid Binding Ig-like Lectin 3
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D015704:CD4 Antigens; D063268:Sialic Acid Binding Ig-like Lectin 3