Concanavalin A enhances ATP resynthesis via de novo pathway in postischemic rat hearts.
Acute post-ischemic cardiac failure was studied in isolated rat hearts. Xylitol, glutamine, aspartic acid and glycine were added during reperfusion, resulting in no inotropic effect. Concanavalin A had a moderate inotropic effect. When concanavalin A added with xylitol, glutamine, aspartic acid and glycine, a rapid recovery of myocardial function and high-energy phosphate was achieved.
Tan
Z T
ZT
Department of Surgery, Colorado Health Sciences Center, Denver 80262.
Tan
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Wang
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XW
D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology*; D004357:Drug Synergism; D005973:Glutamine / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D014993:Xylitol / Q000494:pharmacology
D005973:Glutamine; D003208:Concanavalin A; D001224:Aspartic Acid; D000255:Adenosine Triphosphate; D005998:Glycine; D014993:Xylitol