A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.
We report here the development of an orthotopic-transplant model of human patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary fat pad of nude mice where the tumor tissue grew extensively and metastasized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-science uses of the model are discussed.
Fu
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AntiCancer Inc., San Diego, CA 92110.
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Hoffman
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RM
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D015342:DNA Probes; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation / Q000379:methods; D014183:Transplantation, Heterologous / Q000379:methods
D015342:DNA Probes