title: Pseudo-symmetrical difluoroketones. Highly potent and specific inhibitors of HIV-1 protease.
abstract: A series of novel, pseudo-symmetrical difluoroketones which are highly potent inhibitors of the HIV-1 protease (IC50 = 1.55-0.02 nM) were synthesized. These compounds also possess good antiviral activity by inhibition of the cytopathic effect of HIV-13B in MT-4 cells in vitro.
authors.affiliation: Abbott Laboratories, Abbott Park, IL 60064-3500.
authors.forename: H L
authors.initials: HL
authors.lastname: Sham
authors.forename: D A
authors.initials: DA
authors.lastname: Betebenner
authors.forename: N
authors.initials: N
authors.lastname: Wideburg
authors.forename: A C
authors.initials: AC
authors.lastname: Saldivar
authors.forename: W E
authors.initials: WE
authors.lastname: Kohlbrenner
authors.forename: A
authors.initials: A
authors.lastname: Craig-Kennard
authors.forename: S
authors.initials: S
authors.lastname: Vasavanonda
authors.forename: D J
authors.initials: DJ
authors.lastname: Kempf
authors.forename: J J
authors.initials: JJ
authors.lastname: Clement
authors.forename: J E
authors.initials: JE
authors.lastname: Erickson
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D007659:Ketones; D011994:Recombinant Proteins