Diabetes increases excretion of urinary malonaldehyde conjugates in rats.
The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992) Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.
Gallaher
D D
DD
Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108.
Csallany
A S
AS
Shoeman
D W
DW
Olson
J M
JM
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000652:urine; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde