Characterisation of the central nervous depressant activity of a commercially available valerian root extract.
The evaluation of a commercially available valerian root extract (Valdispert) revealed pronounced sedative properties in the mouse with respect to a reduction in motility and an increase in the thiopental sleeping-time. A direct comparison with diazepam and chlorpromazine revealed a moderate sedative activity for the tested extract. The extract showed only weak anticonvulsive properties.
Leuschner
J
J
LPT Laboratory of Pharmacology, Hamburg, Fed. Rep. of Germany.
Müller
J
J
Rudmann
M
M
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D012890:Sleep / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology; D014632:Valerian
D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D010936:Plant Extracts; D013874:Thiopental; D003975:Diazepam; D002746:Chlorpromazine; D010433:Pentylenetetrazole