title: [Rhabdomyolysis caused by pravastatin and type 1 macrocreatine kinase].
abstract: The authors report a case of rhabdomyolysis which occurred in a 61 year old woman who was receiving pravastatin and who was also found to present with type 1 macrocreatine kinase. Drug induced rhabdomyolysis is common, particularly with HMG Coenzyme A reductase inhibitors. The authors describe the onset of an adverse effect of this type with pravastatin, a recently marketed drug, as has been previously described for lovastatin and simvastatin. The concomitant detection of macrocreatine kinase, the incidence of which is estimated to be between 2 and 5% in the population, raises the question of whether rhabdomyolysis of this type may occur preferentially in patients with this biological anomaly.
authors.affiliation: Service de Cardiologie C, Hôpital Cardiologique, Centre Hospitalier Régional Universitaire, Lille.
authors.forename: E
authors.initials: E
authors.lastname: Decoulx
authors.forename: A
authors.initials: A
authors.lastname: Millaire
authors.forename: P
authors.initials: P
authors.lastname: de Groote
authors.forename: G
authors.initials: G
authors.lastname: Mahieux
authors.forename: G
authors.initials: G
authors.lastname: Ducloux
mesh_terms: D003402:Creatine Kinase / Q000032:analysis* / Q000502:physiology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008875:Middle Aged; D017035:Pravastatin / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*
chemical_list: D003402:Creatine Kinase; D017035:Pravastatin
vernacular_title: Rhabdomyolyse sous pravastatine et macrocréatine kinase de type 1.