Erythrocyte Na+/Li+ countertransport and glomerular hyperfiltration in insulin-dependent diabetics.
Erythrocyte Na+/Li+ countertransport activity was investigated in 11 controls and 22 recent onset type I (insulin-dependent) diabetic patients with normal and high glomerular filtration rates. No differences in Vmax were observed in hyperfiltering compared to normofiltering patients or controls. The Na+/Li+ activity was correlated with blood glucose levels in insulin-dependent diabetics showing good glycemic control. Total cholesterol and triglyceride concentrations were similar among the three groups. In conclusion, enhanced Na+/Li+ countertransport activity is not associated, in our case, with diabetic condition per se and with early glomerular hyperfiltration and cannot be used as a marker of renal involvement in recent onset insulin-dependent diabetics.
Rota
R
R
Département de Néphrologie, Hôpital Necker, Paris, France.
Timsit
J
J
Hannedouche
T
T
Ikeni
A
A
Boitard
C
C
Guicheney
P
P
D000328:Adult; D017920:Antiporters; D001786:Blood Glucose / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D004912:Erythrocytes / Q000737:chemistry / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007678:Kidney Glomerulus / Q000502:physiology*; D008297:Male; D014280:Triglycerides / Q000097:blood
D017920:Antiporters; D001786:Blood Glucose; D002352:Carrier Proteins; D014280:Triglycerides; C045885:sodium-lithium countertransporter; D002784:Cholesterol