Paroxetine binding in the blood platelets of post-traumatic stress disorder patients.
Platelet serotonin (5-HT) uptake, as determined by 3H-paroxetine (PA) binding, was studied in 20 Post-traumatic Stress Disorder (PTSD) patients and 20 normal controls. Kd (an inverse measure of affinity of 3H-PA binding to uptake sites) and Bmax (maximum number of 3H-PA binding sites) of 3H-PA binding were significantly decreased in PTSD patients as compared to normal controls. However, there was no difference in Kd or Bmax between PTSD patients with and without a diagnosis of major depression. The Bmax of 3H-PA binding was negatively correlated with state dependent anxiety score whereas Kd was positively correlated with the Mississippi Scale for Combat-Related PTSD score. The role of serotonergic processes in the psychobiology of PTSD is discussed.
Arora
R C
RC
Section on Biological Psychiatry, Department of Veterans Affairs, Edward Hines, Jr, Hospital (116A7), Hines, IL 60141.
Fichtner
C G
CG
O'Connor
F
F
Crayton
J W
JW
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D017374:Paroxetine / Q000097:blood*; D012701:Serotonin / Q000378:metabolism; D013313:Stress Disorders, Post-Traumatic / Q000097:blood*; D014316:Tritium
D014316:Tritium; D012701:Serotonin; D017374:Paroxetine