Single-dose versus 3-day prophylaxis with ciprofloxacin in transurethral surgery. A clinical trial.
In 235 patients who underwent transurethral surgery, perioperative oral ciprofloxacin prophylaxis was given as a single dose 500 mg versus a 3-day regimen. Out of 180 evaluable patients, 84 received a single dose and 96 received a 3-day course. In the single dose prophylaxis group there were 5 failures and in the 3-day prophylaxis group there were 6 failures. The difference is not significant. In 17 patients whose urine culture preoperatively yielded microorganisms the 3-day prophylaxis significantly eradicated the bacteriuria in 83% of the patients.
Bijl
W
W
Urologic Department, University Hospital, Maastricht, The Netherlands.
Janknegt
R A
RA
D016470:Bacteremia / Q000382:microbiology / Q000517:prevention & control*; D001437:Bacteriuria / Q000382:microbiology / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D014551:Urinary Tract / Q000601:surgery*
D002939:Ciprofloxacin