Morphine sulfate, transdermal fentanyl citrate and ketorolac tromethamine: effects on postoperative pulmonary function.
The physiological effects of morphine sulfate and fentanyl citrate on postoperative pulmonary function demonstrate varying degrees of respiratory depression related to dose, route of administration and pre-existing pathologies. Current postoperative analgesic therapies that include concomitant use of narcotic agonists and nonsteroidal anti-inflammatory drugs require adjustment of drug dosages to provide adequate pain relief while avoiding drug-induced complications. Specific nursing considerations include understanding therapeutic and adverse effects of these agents on pain and ventilation, continuous pain assessment and early recognition and treatment of respiratory depression.
Mason
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Vanderbilt University School of Nursing, Nashville, Tenn.
D000279:Administration, Cutaneous; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D003422:Critical Care; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D020911:Ketorolac Tromethamine; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009730:Nursing Assessment; D010149:Postoperative Pain / Q000188:drug therapy* / Q000451:nursing; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000451:nursing* / Q000503:physiopathology / Q000628:therapy; D014046:Tolmetin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D014325:Tromethamine / Q000008:administration & dosage / Q000009:adverse effects*
D000700:Analgesics; D004338:Drug Combinations; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D009020:Morphine; D014046:Tolmetin; D005283:Fentanyl