title: Prediction of response to haloperidol dose reduction by Span of Apprehension measures for treatment-refractory schizophrenic patients.
abstract: Thirteen treatment-refractory schizophrenic patients participated in a haloperidol reduction study. Two of the subjects were unable to tolerate medication reduction. These subjects were comparable to the other patients in terms of initial clinical variables but were outliers on baseline accuracy and reaction time measures from the Span of Apprehension. The results suggest that aspects of basic visual processing and motor response speed may identify patients who require higher neuroleptic doses.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine.
authors.forename: M F
authors.initials: MF
authors.lastname: Green
authors.forename: J
authors.initials: J
authors.lastname: Mintz
authors.forename: L
authors.initials: L
authors.lastname: Bowen
authors.forename: B D
authors.initials: BD
authors.lastname: Marshall
authors.forename: T G
authors.initials: TG
authors.lastname: Kuehnel
authors.forename: J L
authors.initials: JL
authors.lastname: Hayden
authors.forename: R P
authors.initials: RP
authors.lastname: Liberman
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005556:Form Perception / Q000187:drug effects; D006220:Haloperidol / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D006220:Haloperidol