title: In vitro antimicrobial activity of CP-99433 compared with other fluoroquinolones.
abstract: CP-99433 is a new C-7 diazabicyclofluoroquinolone with a broad spectrum of activity that includes Enterobacteriaceae, Gram-positive cocci, and nonenteric Gram-negative bacilli. Potent activity was demonstrated against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC90, 0.5 microgram/ml), Xanthomonas maltophilia (MIC90, 1 microgram/ml), and all Streptococcus species (MIC90s, 0.25-1 microgram/ml). Only CP-99433 was active against Enterococcus faecium (MIC50, 2 micrograms/ml). CP-99433 also demonstrated activity against several ciprofloxacin-resistant staphylococci. Additional studies of CP-99433 activity appear indicated.
authors.affiliation: Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
authors.forename: D M
authors.initials: DM
authors.lastname: Johnson
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: M E
authors.initials: ME
authors.lastname: Erwin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D015365:Enoxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; C082982:CP 99433; D015365:Enoxacin