title: The potential of vervet monkeys (Cercopithecus aethiops) and baboons (Papio anubis) as models for the study of the immunology of Echinococcus granulosus infections.
abstract: Nine vervet monkeys and nine baboons were infected with eggs of Echinococcus granulosus per os. Six of the vervets and one of the baboons possessed hydatid cysts at autopsy, 15-28 months post-infection. The sequential IgG response to hydatid fluid and protoscolex antigens showed considerable inter-animal variation. Infected vervets and baboons became seropositive after an average of 8 months post-infection. Considerable fluctuation in the IgG response was observed, particularly to the hydatid fluid antigen which, in humans, may contribute to the existence of a significant proportion of seronegative individuals. Vervets, in particular, may be useful to study immunological events associated with exposure, development and resolution of hydatid disease in outbred human populations.
authors.affiliation: Department of Biological Sciences, University of Salford, UK.
authors.forename: M T
authors.initials: MT
authors.lastname: Rogan
authors.forename: I
authors.initials: I
authors.lastname: Marshall
authors.forename: G D
authors.initials: GD
authors.lastname: Reid
authors.forename: C N
authors.initials: CN
authors.lastname: Macpherson
authors.forename: P S
authors.initials: PS
authors.lastname: Craig
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D000947:Antigens, Helminth / Q000276:immunology; D002522:Chlorocebus aethiops / Q000469:parasitology; D004195:Disease Models, Animal; D004443:Echinococcosis / Q000276:immunology*; D004446:Echinococcus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D010215:Papio / Q000469:parasitology
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G