Effects of a human urinary kininogenase (SK-827) on cerebral and cutaneous microcirculation in rabbits.
Pharmacological effects of a human urinary kininogenase (SK-827) on the cerebral and cutaneous microcirculation were studied in anesthetized normal rabbits. Intravenous administration of SK-827 had no effect on the diameter of pial arterioles or the hemoglobin content (IHb) of the brain. On the other hand, SK-827 increased IHb of the skin, dose-dependently and dilated cutaneous arterioles transiently with increased capillary red blood cell velocity. These findings suggest that the pharmacological effects of SK-827 on the microcirculation of the brain and the skin differ from each other due to the activity of the autoregulatory mechanism.
Nagano
H
H
Department of Pharmacology, Mie Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Japan.
Suzuki
T
T
Hayashi
M
M
Asano
M
M
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000494:pharmacology* / Q000652:urine; D008833:Microcirculation / Q000187:drug effects; D011817:Rabbits; D012867:Skin / Q000098:blood supply*
D007610:Kallikreins