title: Quantitative interpretation of magnetization transfer.
abstract: Magnetization transfer contrast (MTC) experiments using off-resonance irradiation have been performed with an agar gel model by systematically varying offset frequency, amplitude of the RF irradiation and gel concentration. The experimental results are shown to be quantitatively modelled by a two-pool system consisting of a liquid pool with a Lorentzian line shape and a small semisolid pool with a Gaussian lineshape. The fitted model yields physically realistic fundamental parameters with a T2 of the semisolid pool of 13 microseconds. Further analysis shows that the off-resonance irradiation MTC experiment had significant limitations in its ability to saturate the semisolid pool without directly affecting the liquid component.
authors.affiliation: Sunybrook Health Science Centre, University of Toronto, Ontario, Canada.
authors.forename: R M
authors.initials: RM
authors.lastname: Henkelman
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: Q S
authors.initials: QS
authors.lastname: Xiang
authors.forename: G J
authors.initials: GJ
authors.lastname: Stanisz
authors.forename: S D
authors.initials: SD
authors.lastname: Swanson
authors.forename: M J
authors.initials: MJ
authors.lastname: Bronskill
mesh_terms: D000362:Agar; D005782:Gels; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008961:Models, Structural; D008962:Models, Theoretical
chemical_list: D005782:Gels; D000362:Agar