Inhibition of the neutrophil respiratory burst by neoglycoalbumin.
Both human serum fraction V albumin subjected to enhanced glycation by incubation with glucose, and a highly glycated albumin fraction prepared by m-phenyl boronic acid agarose affinity chromatography, when compared with albumin preparations of lesser glycation but equal concentration, inhibited the respiratory burst of the human neutrophil. Native albumin also inhibited the respiratory burst in proportion to its concentration. It is suggested that the neoglycoalbumin impairs glucose utilization by the neutrophil.
Candlish
J K
JK
Department of Pathology, National University of Singapore, Kent Ridge.
D000418:Albumins / Q000494:pharmacology*; D019270:Fructosamine; D006031:Glycosylation; D006595:Hexosamines / Q000032:analysis; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D016897:Respiratory Burst / Q000187:drug effects*
D000418:Albumins; D006595:Hexosamines; D019270:Fructosamine