title: Influence of meal ingestion on insulin profiles following intraperitoneal delivery.
abstract: This study evaluated the effect of meal ingestion on intraperitoneal insulin absorption in type I diabetic patients with an implanted pump for long-term intraperitoneal insulin delivery. On four separate occasions, patients (n = 7) were administered 15 IU insulin as a 20-minute square-wave infusion using their implanted device; hypoglycemia was prevented by intravenous infusion of 10% dextrose at a variable rate. Two studies were performed during fasting conditions (n = 2 fasting tests) and two studies after the administration of an 800-kcal standard meal (n = 2 postprandial tests). An insulin peak of 630 +/- 545.4 pmol/L (mean +/- SD) in fasting tests and 696 +/- 420.5 pmol/L in postprandial tests was reached in the peripheral circulation after 45 +/- 11.7 and 45 +/- 14.7 minutes, respectively, with no significant difference between the two experimental conditions. Areas under the insulin curves were not significantly different in fasting and postprandial tests (51,500 +/- 34,278 v 50,916 +/- 20,558 pmol/L.min-1, respectively; NS). In type I diabetic patients receiving long-term intraperitoneal insulin therapy, the increase in splanchnic blood flow following ingestion of a standard meal does not accelerate the appearance of insulin in the peripheral circulation.
authors.affiliation: Istituto Scientifico H San Raffaele, University of Milano, School of Medicine, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Scavini
authors.forename: A I
authors.initials: AI
authors.lastname: Pincelli
authors.forename: C
authors.initials: C
authors.lastname: Cruciani
authors.forename: B
authors.initials: B
authors.lastname: Giberti
authors.forename: E
authors.initials: E
authors.lastname: Orsi
authors.forename: G
authors.initials: G
authors.lastname: Galimberti
authors.forename: G
authors.initials: G
authors.lastname: Petrella
authors.forename: M
authors.initials: M
authors.lastname: Cristallo
authors.forename: G
authors.initials: G
authors.lastname: Pozza
authors.forename: P
authors.initials: P
authors.lastname: Micossi
mesh_terms: D000328:Adult; D001775:Blood Circulation; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism; D004435:Eating / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D015918:Infusion Pumps, Implantable; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose