Differences in acetylcholine receptor-antibody interactions between extraocular and extremity muscle fibers.
There are two types of motor nerve innervation patterns and AChR distributions in human EOM: single and multiple. The latter is further divided into two subgroups that are restricted to EOM and are not found in limb muscles. Epitopes that are unique to EOM end-plates exist. Some OMG patients have antibodies that are specifically targeted to those epitopes. These antibodies are functionally active and can cause AChR loss in EOM end-plates. In addition to AChRs, specific components constructing the microenvironment surrounding them may also be involved in the susceptibility of EOM in myasthenia gravis.
Oda
K
K
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D003598:Cytoskeletal Proteins / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D008565:Membrane Proteins; D051379:Mice; D009045:Motor Endplate / Q000276:immunology / Q000378:metabolism; D009157:Myasthenia Gravis / Q000276:immunology*; D009801:Oculomotor Muscles / Q000276:immunology*; D011978:Receptors, Nicotinic / Q000276:immunology / Q000378:metabolism*; D049411:Utrophin
D001323:Autoantibodies; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D011978:Receptors, Nicotinic; C483600:Utrn protein, mouse; D049411:Utrophin