title: Sequences related to the ox pancreatic ribonuclease coding region in the genomic DNA of mammalian species.
abstract: Mammalian pancreatic ribonucleases form a family of homologous proteins that has been extensively investigated. The primary structures of these enzymes were used to derive phylogenetic trees. These analyses indicate that the presence of three strictly homologous enzymes in the bovine species (the pancreatic, seminal, and cerebral ribonucleases) is due to gene duplication events which occurred during the evolution of ancestral ruminants. In this paper we present evidence that confirms this finding and that suggests an overall structural conservation of the putative ribonuclease genes in ruminant species. We could also demonstrate that the sequences related to ox ribonuclease coding regions present in genomic DNA of the giraffe species are the orthologues of the bovine genes encoding the three ribonucleases mentioned above.
authors.affiliation: Dipartimento di Chimica Organica e Biologica, Università di Napoli, Italy.
authors.forename: H J
authors.initials: HJ
authors.lastname: Breukelman
authors.forename: J J
authors.initials: JJ
authors.lastname: Beintema
authors.forename: E
authors.initials: E
authors.lastname: Confalone
authors.forename: C
authors.initials: C
authors.lastname: Costanzo
authors.forename: M P
authors.initials: MP
authors.lastname: Sasso
authors.forename: A
authors.initials: A
authors.lastname: Carsana
authors.forename: M
authors.initials: M
authors.lastname: Palmieri
authors.forename: A
authors.initials: A
authors.lastname: Furia
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000235:genetics*; D003001:Cloning, Molecular; D017124:Conserved Sequence; D004247:DNA; D008322:Mammals / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D012259:Ribonuclease, Pancreatic / Q000235:genetics*; D013045:Species Specificity
chemical_list: D004247:DNA; D012259:Ribonuclease, Pancreatic