title: Selective IgM deficiency in a patient with Hashimoto's disease.
abstract: A 70-year-old man with Hashimoto's disease had selective IgM deficiency, while other immunoglobulin levels were normal. In vitro mixing experiments were carried out in which B cells and T cells from the patient and from a healthy control donor were co-cultured in the presence of pokeweed mitogen, in order to investigate the etiology of IgM hypoproduction. The results indicated that the patient had B-cell dysfunction, involving the impairment of B-cell differentiation. In addition, both IgG of the healthy control donor and thyroid hormone may play important roles in the pathogenesis of this case.
authors.affiliation: Department of Internal Medicine, Nishijin Hospital, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Tanigawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahashi
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamura
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Sugino
authors.forename: M
authors.initials: M
authors.lastname: Kondo
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000172:deficiency*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M