Coordinated regulation of amino sugar-synthesizing and -degrading enzymes in Escherichia coli K-12.
The intracellular concentration of the enzyme glucosamine-6-phosphate synthase, encoded by the gene glmS in Escherichia coli, is repressed about threefold by growth on the amino sugars glucosamine and N-acetylglucosamine. This regulation occurs at the level of glmS transcription. It is not due just to the presence of intracellular amino sugar phosphates, because mutations which derepress the genes of the nag regulon (coding for proteins involved in the uptake and metabolism of N-acetylglucosamine) also repress the expression of glmS in the absence of exogenous amino sugars.
Plumbridge
J A
JA
Institut de Biologie Physico-Chimique (URA1139), Paris, France.
Cochet
O
O
Souza
J M
JM
Altamirano
M M
MM
Calcagno
M L
ML
Badet
B
B
D000117:Acetylglucosamine / Q000378:metabolism; D019747:Aldose-Ketose Isomerases; D000581:Amidohydrolases / Q000235:genetics / Q000378:metabolism; D000606:Amino Sugars / Q000378:metabolism*; D001483:Base Sequence; D002238:Carbohydrate Epimerases / Q000235:genetics / Q000378:metabolism; D004790:Enzyme Induction; D004794:Enzyme Repression; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D005944:Glucosamine / Q000378:metabolism; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
D000606:Amino Sugars; D012333:RNA, Messenger; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D000581:Amidohydrolases; C018717:N-acetylglucosamine-6-phosphate deacetylase; C020582:glucosamine-6-phosphate isomerase; D002238:Carbohydrate Epimerases; D019747:Aldose-Ketose Isomerases; D005944:Glucosamine; D000117:Acetylglucosamine