title: [The enhancement of immune suppression by local laser irradiation in rats exposed to cyclophosphane].
abstract: The authors experimentally studied where low-energy laser radiation (LELR) can be used to enhance cyclophosphanum-induced immunodepression. Preliminary LELR of the adrenal region and cyclophosphanum, 4 mg/kg, resulted in a more profound decrease in the intensity of a primary immune response as compared to the controls received a pseudoradiation and the cytostatic in the same dosage. The findings suggest that laser radiation can be applied to the adrenal region in the clinical setting to reduce a dose of the cytostatic administered and hence adverse effects, by preserving the therapeutical level of immunodepression.
authors.forename: T V
authors.initials: TV
authors.lastname: Konchugova
authors.forename: S B
authors.initials: SB
authors.lastname: Pershin
authors.forename: A A
authors.initials: AA
authors.lastname: Minenkov
mesh_terms: D000311:Adrenal Glands; D000818:Animals; D001921:Brain; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007108:Immune Tolerance / Q000187:drug effects* / Q000528:radiation effects*; D007114:Immunization; D007834:Lasers; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects
chemical_list: D003520:Cyclophosphamide
vernacular_title: Usilenie immunnoĭ supressii lokal'nymi lazernymi oblucheniiami u krys, podvergnutykh vozdeĭstviiu tsiklofosfana.