Extracellular matrix and gene expression in mammary epithelium.
Correct cellular environment is required for the differentiation of many cell types. In mammary epithelium the extracellular matrix as well as lactogenic hormones cooperate to direct accurate tissue-specific gene expression. Current evidence indicates that the promoters of milk protein genes contain elements that are regulated by both extracellular matrix and hormones. Some mechanisms by which the extracellular matrix might control transcription are considered.
Streuli
C H
CH
Department of Cell and Structural Biology, University of Manchester, UK.
D000818:Animals; D001485:Basement Membrane; D002454:Cell Differentiation; D004848:Epithelium / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008894:Milk Proteins / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype
D008894:Milk Proteins