title: The role of small nuclear RNAs in RNA splicing.
abstract: Recent genetic and biochemical experiments have revealed an intimate and dynamic role for small nuclear RNAs (snRNAs) in multiple steps of RNA-splicing reactions. Both snRNA-substrate and snRNA-snRNA interactions are involved. These interactions concern not only splice site and branch point definition, but also the catalytic reactions of the first and second steps of splicing. Studies reveal a striking conservation between snRNA interactions and interactions found in RNAs encoded by genes with group II self-splicing introns.
authors.affiliation: Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186.
authors.forename: M
authors.initials: M
authors.lastname: McKeown
mesh_terms: D000818:Animals; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D012326:RNA Splicing; D012342:RNA, Small Nuclear / Q000378:metabolism*
chemical_list: D012342:RNA, Small Nuclear