Effect of the rice bran-derived phytosterol cycloartenol ferulic acid ester on the central nervous system.
In order to investigate the effect of cycloartenol ferulic acid ester (CFE, CAS 21238-33-5), a component of gamma-oryzanol which is a phytosterol derived from rice bran, on the central nervous system, a variety of pharmacological tests were performed. It was shown that CFE had a suppressant effect on the central nervous system, but its properties were different from those of existing major and minor tranquilizers. In addition, its efficacy in several models of cerebral dysfunction was demonstrated. Since any clear effects could not be obtained under the treatments with gamma-oryzanol, CFE seems to be more useful than gamma-oryzanol. Thus the results of this study suggest that CFE may serve as a new plant-derived cerebral activator possessing a wide range of pharmacological actions.
Hiraga
Y
Y
Zeria Pharmaceutical Co., Ltd., Central Research Laboratories, Saitama, Japan.
Nakata
N
N
Jin
H
H
Ito
S
S
Sato
R
R
Yoshida
A
A
Mori
T
T
Ozeki
M
M
Ikeda
Y
Y
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D003220:Conflict, Psychological; D003373:Coumaric Acids / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D012275:Oryza / Q000737:chemistry*; D010424:Pentobarbital / Q000494:pharmacology; D010840:Phytosterols / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy
D000927:Anticonvulsants; D003373:Coumaric Acids; D000960:Hypolipidemic Agents; D010840:Phytosterols; C055272:cycloartenol ferulic acid ester; D012110:Reserpine; D010424:Pentobarbital