title: Changing patterns in the treatment of early breast cancer: a historical perspective and a review of changing local trends.
abstract: Over the past 50 years, a variety of surgical procedures have been advocated for the treatment of operable breast cancer, ranging from local excision to supraradical mastectomy. Today, the surgical treatment of breast cancer remains highly contentious. We review the historical development of breast cancer surgery and analyse the available evidence supporting conservative procedures. We also express our opinions on the treatment of early breast cancer and illustrate the changing patterns of surgery with our experience at National University Hospital.
authors.affiliation: Department of Surgery, National University Hospital, Singapore.
authors.forename: E
authors.initials: E
authors.lastname: Sim
authors.forename: T C
authors.initials: TC
authors.lastname: Lim
authors.forename: W T
authors.initials: WT
authors.lastname: Tan
authors.forename: A
authors.initials: A
authors.lastname: Rauff
mesh_terms: D001943:Breast Neoplasms / Q000266:history* / Q000601:surgery; D005260:Female; D049668:History, 15th Century; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D008408:Mastectomy / Q000266:history* / Q000639:trends; D015411:Mastectomy, Modified Radical / Q000266:history / Q000639:trends; D015409:Mastectomy, Radical / Q000266:history / Q000639:trends