Comparative study of short term results in two multidrug regimens in multibacillary leprosy.
Thirty lepromatous and Borderline lepromatous leprosy patients were treated with multidrug therapy in an open trial. Fifteen of them received the standard WHO multidrug regimen ie., rifampicin 600 mg and clofazimine 300 mg monthly, supervised, and dapsone 100 mg daily and clofazimine 100 mg on alternate days as self administered; the other 15 received a modified multidrug therapy regimen comprising of rifampicin 600 mg, clofazimine 100 mg and dapsone 100 mg daily for 21 days as suggested by the Indian Association of Leprologists, followed by the standard WHO regimen. The observation period was six months. Clinical, bacteriological, histological and immunological parameters were studied. The fall in morphological index was much faster in patients receiving modified multidrug therapy regimen compared to those receiving the standard WHO regimen. Otherwise, there was no difference between the two groups of patients. Five patients developed type I (upgrading) reaction with one developing ulnar nerve paralysis. No untoward effects of drugs were noted in the study subjects except for darkening of skin colour of all the patients.
Singh
R P
RP
Military Hospital, Jabalpur.
Tiwari
V D
VD
Chattopadhyay
S P
SP
D000328:Adult; D000368:Aged; D002991:Clofazimine / Q000008:administration & dosage* / Q000009:adverse effects; D003622:Dapsone / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D015440:Leprosy, Lepromatous / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage* / Q000009:adverse effects
D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin