title: Effects of mebendazole, albendazole, and praziquantel on succinate dehydrogenase, fumarate reductase, and malate dehydrogenase in Echinococcus granulosus cysts harbored in mice.
abstract: Echinococcus granulosus cyst wall possess high biochemical activities of malate dehydrogenase (MD) and fumarate reductase (FR), but low activity of succinate dehydrogenase (SD), suggesting that the cyst wall may utilize a partial reverse tricarboxylic acid cycle. When infected mice were given intragastrically with mebendazole, 25-50 mg.kg-1.d-1, albendazole 300 mg.kg-1.d-1 or praziquantel 500 mg.kg-1.d-1 for 7-14 d, no apparent effects on SD and FR activities of the cyst wall were found, while the MD activity was suppressed by all the 3 drugs, the inhibition rates being 34.6-61.6%, 59.8%, and 50.6%, respectively. The results suggested that MD may not be an important target for the antihydatidosis drugs.
authors.affiliation: Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai.
authors.forename: S H
authors.initials: SH
authors.lastname: Xiao
authors.forename: J J
authors.initials: JJ
authors.lastname: Feng
authors.forename: H F
authors.initials: HF
authors.lastname: Guo
authors.forename: P Y
authors.initials: PY
authors.lastname: Jiao
authors.forename: M Y
authors.initials: MY
authors.lastname: Yao
authors.forename: W
authors.initials: W
authors.lastname: Jiao
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D004443:Echinococcosis / Q000201:enzymology; D004446:Echinococcus / Q000201:enzymology*; D005260:Female; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008463:Mebendazole / Q000494:pharmacology*; D051379:Mice; D010088:Oxidoreductases / Q000378:metabolism*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011223:Praziquantel / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
chemical_list: D011223:Praziquantel; D008463:Mebendazole; D010088:Oxidoreductases; D008291:Malate Dehydrogenase; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH); D013385:Succinate Dehydrogenase; D015766:Albendazole