title: Combination of anticholinergic agent and H2 receptor antagonist in duodenal ulcer treatment--a randomized, double blind multicenter study.
abstract: BACKGROUND
  The acid suppressive abilities of H2 receptor antagonists and anticholinergics have been claimed to be additive.
  
  
  METHODS
  A multicenter, double-blind, randomized trial comparing ranitidine (150 mg) plus propantheline bromide 15 mg at bedtime to ranitidine 300 mg alone at bedtime was conducted in 161 patients with endoscopically confirmed uncomplicated duodenal ulcer.
  
  
  RESULTS
  After six weeks of therapy, ulcer healing rates in the two groups were comparable ie 80% in the combination group (ranitidine + propantheline) and 79.4% in the ranitidine group. Pain relief after one, two and four weeks of treatment was also comparable in the two groups. Side effects to drugs were minor and comparable in both the groups.
  
  
  CONCLUSIONS
  A combination of 150 mg ranitidine and 15 mg propantheline bromide is as efficacious as 300 mg ranitidine in inducing healing of uncomplicated duodenal ulcers, with similar side-effects but at greatly reduced cost.
authors.affiliation: Indira Gandhi Institute of Medical Sciences, Patna.
authors.forename: B K
authors.initials: BK
authors.lastname: Agrawal
authors.forename: A
authors.initials: A
authors.lastname: Suman
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: S L
authors.initials: SL
authors.lastname: Broor
authors.forename: P
authors.initials: P
authors.lastname: Rajasambandam
authors.forename: K R
authors.initials: KR
authors.lastname: Palaniswamy
authors.forename: A T
authors.initials: AT
authors.lastname: Mohan
authors.forename: J P
authors.initials: JP
authors.lastname: Gupta
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011413:Propantheline / Q000008:administration & dosage / Q000627:therapeutic use*; D011899:Ranitidine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011413:Propantheline; D011899:Ranitidine