[Evolution of delta bilirubin/conjugated bilirubins ratio in serum after live transplantation].
Serum delta-bilirubin measured in relationship to total bilirubin could be a liver function test in hepatobiliary diseases and even a marker of early rejection after liver transplantation. Delta-bilirubin bound to albumin constitutes with mono and diglucuroconjugates, conjugated bilirubins. We determined the delta-bilirubin/conjugated bilirubins ratio and studied its value in various complications in 16 liver recipients. The results were compared with alanine aminotransferase activity and prothrombin index. Hyperbilirubinemia and a delta-bilirubin/conjugated bilirubins ratio lower than 40% were observed initially. After 15 days, the delta-bilirubin/conjugated bilirubins ratio evolved differently according to the functional state of the graft, which allowed to distinguish three patient groups: in patients with good graft function, the ratio increased regularly to reach 65% or more on the 30th day; in patients with dysfunctional episodes, the ratio was always less than or equal to 40% and did not increase after the 15th day; in other patients, the ratio was lower than 40% and dropped suddenly before death. After liver transplantation, the delta-bilirubin/conjugated bilirubins ratio may be a simple liver function marker. Alone, however, it cannot be used to assess acute rejection.
Cherruau
B
B
Laboratoire de Biochimie A, Hôpital Cochin, Paris.
Nguyen-Dai
D
D
Calmus
Y
Y
Dang-Vu
B
B
Marien
M
M
Houssin
D
D
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood*; D005260:Female; D006084:Graft Rejection / Q000503:physiopathology; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011516:Prothrombin / Q000032:analysis; D013997:Time Factors
D011516:Prothrombin; D000410:Alanine Transaminase; D001663:Bilirubin
Evolution du rapport delta bilirubine/bilirubines conjuguées dans le sérum après transplantation hépatique.