title: [Immunoprophylaxis of recurrence of T1 G2 bladder tumors with interferon alpha-2b].
abstract: Assessment of results with -2b Interferon used as prophylaxis in 20 patients who underwent surgery for T1,G2 urothelial vesical tumours. Dosage was weekly intravesical instillation of 50 x 10(6) IU for three months and then monthly up to one year treatment. Mean follow-up was 17.20 months (4-41 months). Relapse rate over this time was 50%, all before 15 months, a relapsing ratio of 2.82% patients/month and a disease-free interval of 27.5 months. Chances of being disease-free at 30 months is 48.21%. Progression of disease, whether in grade or stage, was observed in 25% cases. No patient showed relevant changes or side effects during treatment, except for 5 patients who reported mictional symptoms mainly during the first 3 months, none of which required discontinuation of treatment. From the data obtained, it can be deduced that for the time being no reason justifies the use of -2b Interferon versus other conventional chemotherapeutical or immunotherapeutical (BCG) agents in the prophylaxis of this type of tumours.
authors.affiliation: Servicio de Urología, Hospital General de Albacete.
authors.forename: A S
authors.initials: AS
authors.lastname: Salinas Sánchez
authors.forename: I
authors.initials: I
authors.lastname: Hernández Millán
authors.forename: J M
authors.initials: JM
authors.lastname: Pastor Guzmán
authors.forename: M
authors.initials: M
authors.lastname: Martínez Martín
authors.forename: L
authors.initials: L
authors.lastname: Cañamares Pabolaza
authors.forename: J A
authors.initials: JA
authors.lastname: Virseda Rodríguez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control*; D009367:Neoplasm Staging; D011994:Recombinant Proteins; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
vernacular_title: Inmunoprofilaxis de recidivas de tumores vesicales T1 G2 con interferón alpha-2b.