An acute and focal osteopenia model using ovariectomized rats: a rapid detection of the protective effect of salmon calcitonin.
A screening method for anti-osteoporotics using ovariectomized rats was designed using a compact method to monitor the bone density. It was found that ovariectomy (OVX) of Wistar female rats (11 weeks old) induced acute and focal osteopenia within 2 weeks, which responded well to intermittent salmon calcitonin (SCT: 5 and 20 U/kg, s.c., every other day) employed as the standard anti-osteoporotic and injected up to 4 weeks with or without a delay of 2 weeks after OVX.
Nakamuta
H
H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Sasaki
M
M
Ichikawa
M
M
Koida
M
M
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000473:pathology / Q000517:prevention & control*; D002116:Calcitonin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004967:Estrogens / Q000172:deficiency; D005260:Female; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000473:pathology
D000700:Analgesics; D004967:Estrogens; C028815:salmon calcitonin; D002116:Calcitonin