title: Role of vasoactive intestinal polypeptide (VIP), secretin and gastrin in the genesis of the late exocrine pancreatic hypersecretion, food intake dependent in conscious dogs.
abstract: Plasma levels of vasoactive intestinal polypeptide (VIP), secretin and gastrin were studied in four saphenous vein-catheterized dogs during the first 12 h after ingestion of a standard solid meal. Under these conditions we found significant postprandial increases in secretion only, which rose from a basal value of 219 +/- 27 pg/ml to 449 +/- 66 pg/ml 60 min postprandial (p < 0.001), and remained elevated until 4 h after food intake. However, no increase was seen from 8 to 12 h in any of the hormones studied, indicating that they are not directly involved in the enhancement of exocrine pancreatic secretion during this period.
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology, Faculty of Pharmacy, University of Granada, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Huertas
authors.forename: M
authors.initials: M
authors.lastname: Mañas
authors.forename: M C
authors.initials: MC
authors.lastname: Ballesta
authors.forename: F J
authors.initials: FJ
authors.lastname: Mataix
authors.forename: E
authors.initials: E
authors.lastname: Martinez-Victoria
mesh_terms: D000818:Animals; D004032:Diet; D004285:Dogs; D004435:Eating / Q000502:physiology*; D005260:Female; D005755:Gastrins / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D012633:Secretin / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
chemical_list: D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D014660:Vasoactive Intestinal Peptide