Intracellular parasitism of Legionella and signaling in eukaryotic cells.
In this review the phenomenon of antibacterial activity of phagocytes and its relationship to the general system of signal transduction in eukaryotic cells is examined. Data are reviewed that support the hypothesis that interference in transduction of regulatory signals during microbial invasion could be caused by specific bacterial products and lead to an inadequate bactericidal response, and hence multiplication of the bacteria in a host. In this connection, information concerning virulence factors of the facultative intracellular parasite Legionella is discussed.
Belyi
Y F
YF
N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D007875:Legionella / Q000276:immunology*; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction
D011494:Protein Kinases; D019204:GTP-Binding Proteins