title: A phase II evaluation of human lymphoblastoid interferon (Wellferon) in relapsed high grade malignant glioma. Medical Research Council Brain Tumour Working Party.
abstract: During the 1980s a number of studies suggested there might be a role for interferon in the treatment of high grade gliomas. In the light of these reports a formal Phase II evaluation of human lymphoblastoid interferon (Wellferon) was undertaken in patients with high grade gliomas which had relapsed after conventional radiotherapy; 14 patients were treated and no objective clinical responses were seen. This indicates that the overall response rate to interferon therapy in this situation would be less than 20%. It is therefore concluded that interferon administration is unlikely to be of value in the management of relapsed high grade gliomas.
authors.affiliation: Department of Radiotherapy, Royal Hospital, Wolverhampton, UK.
authors.forename: T J
authors.initials: TJ
authors.lastname: Priestman
authors.forename: N M
authors.initials: NM
authors.lastname: Bleehen
authors.forename: R
authors.initials: R
authors.lastname: Rampling
authors.forename: S
authors.initials: S
authors.lastname: Stenning
authors.forename: A J
authors.initials: AJ
authors.lastname: Nethersell
authors.forename: J
authors.initials: J
authors.lastname: Scott
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
chemical_list: D016898:Interferon-alpha