Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants.
Various xanthones as well as quercetin have been shown to exhibit antiplatelet activity. A series of anthraquinones analogues structurally related to xanthones and a series of quercetin-related compounds were tested for their antiplatelet effects. Emodin, frangulin B, kaempferol tetraacetate, quercetin-3-O-galactoside octaacetate, rhamnazin triacetate, and rhamnetin tetraacetate were found to be potent antiplatelet agents, and 1,8-dihydroxy-6-methoxy-3-methylanthraquinone 8-O-rhamnosyl-(1-->2)-glucoside, rhamnustrioside undecaacetate, rutin decaacetate, and quercetin-3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-galactopyranos ide decaacetate showed significant antiplatelet effects. Quercetin showed vasorelaxing action in rat thoracic aorta.
Chung
M I
MI
Natural Products Research Center, Kaohsiung Medical College, Taiwan, Republic of China.
Gan
K H
KH
Lin
C N
CN
Ko
F N
FN
Teng
C M
CM
D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013624:Taiwan; D014665:Vasodilator Agents / Q000302:isolation & purification* / Q000494:pharmacology
D000880:Anthraquinones; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D011794:Quercetin