title: Effect of obesity and fertility status on sex steroid levels in men.
abstract: Endocrine studies were performed on fertile and infertile obese men and compared with fertile and infertile nonobese men in order to determine the independent and codependent effects of obesity and fertility status on the male hypothalamic-pituitary gonadal axis. The obese infertile group exhibited significant endocrinologic changes as compared with fertile nonobese control group which was not observed in any of the other three groups. Serum testosterone was significantly lower. The testosterone/estradiol ratio was significantly lower despite a lack of significant change in serum estradiol levels. Serum steroid hormone binding globulin (SHBG) was significantly lower which correlated with elevated bioavailability of both testosterone and estradiol in the obese infertile group. Serum luteinizing hormone levels were no different, suggesting that free testosterone levels were unchanged. Obese infertile men exhibit endocrinologic changes that are not observed in men with either obesity or infertility alone. Reduction of serum SHBG, total testosterone, and testosterone/estradiol ratio appear to be a marker of infertility among obese men.
authors.affiliation: Department of Urology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: J P
authors.initials: JP
authors.lastname: Jarow
authors.forename: J
authors.initials: J
authors.lastname: Kirkland
authors.forename: D R
authors.initials: DR
authors.lastname: Koritnik
authors.forename: W T
authors.initials: WT
authors.lastname: Cefalu
mesh_terms: D015415:Biomarkers; D004958:Estradiol / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*
chemical_list: D015415:Biomarkers; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol