title: Inhibition of Acanthamoeba species by Pseudomonas aeruginosa: rationale for their selective exclusion in corneal ulcers and contact lens care systems.
abstract: Cocultivation of Acanthamoeba castellanii and Acanthamoeba polyphaga with live Pseudomonas aeruginosa and with broth filtrates of P. aeruginosa proved equally lethal to the Acanthamoeba spp. The P. aeruginosa-induced amebicidal activity is apparently toxin mediated and has two operative modes: it can function through binding of P. aeruginosa to the ameba membrane and in the presence of one or more P. aeruginosa exoproducts.
authors.affiliation: Clinical Microbiology Laboratories, Mount Sinai Hospital, New York, New York 10029.
authors.forename: M N
authors.initials: MN
authors.lastname: Qureshi
authors.forename: A A
authors.initials: AA
authors.lastname: Perez
authors.forename: R M
authors.initials: RM
authors.lastname: Madayag
authors.forename: E J
authors.initials: EJ
authors.lastname: Bottone
mesh_terms: D000048:Acanthamoeba / Q000254:growth & development* / Q000382:microbiology / Q000472:pathogenicity; D000818:Animals; D001422:Bacterial Adhesion; D003261:Contact Lenses / Q000009:adverse effects*; D003320:Corneal Ulcer / Q000209:etiology*; D004463:Ecology; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity / Q000502:physiology*