Fibroblast-stimulating factor 1, a novel lymphokine produced in schistosomal egg granulomas, stimulates liver fat-storing cells in vitro.
We report that the novel lymphokine fibroblast-stimulating factor 1, produced within hepatic schistosomal egg granulomas, stimulates liver fat-storing cells (FSC) in vitro to proliferate and express fibronectin genes. Because FSC are critical in hepatic fibrogenesis generally, we propose that in vivo stimulation of FSC by fibroblast-stimulating factor 1 may be an important step in schistosomal liver fibrosis.
Greenwel
P
P
Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, Massachusetts 02111.
Wyler
D J
DJ
Rojkind
M
M
Prakash
S
S
D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects*; D005353:Fibronectins / Q000235:genetics; D006099:Granuloma / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008222:Lymphokines / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010063:Ovum; D011347:Procollagen / Q000235:genetics; D012547:Schistosoma / Q000378:metabolism*; D012552:Schistosomiasis / Q000378:metabolism*
D005353:Fibronectins; D008222:Lymphokines; D011347:Procollagen