title: Magnetic resonance abnormalities in HIV infection: a study in the drug-user risk group.
abstract: Cognitive impairment is a frequent complication of advanced human immunodeficiency virus-1 (HIV-1) infection. However, structural imaging of the brain has not revealed abnormalities that precede the onset of clinical abnormalities. Cranial magnetic resonance (MR) studies were performed in 28 male subjects with intravenous drug use histories; nine were HIV-1 seronegative, 11 were HIV-1 seropositive but asymptomatic, and eight were seropositive and met symptomatic criteria for acquired immune deficiency syndrome (AIDS). Cortical atrophy, but not the degree of ventricular enlargement or signal abnormalities, was increased in the seropositive group compared with the seronegative group and also differed between asymptomatic seropositive and seronegative patients. An increased level of cortical atrophy may reflect the early impact of HIV-1 infection on the brain.
authors.affiliation: Psychiatry Service, Veterans Affairs Medical Center, Bronx, NY 10468.
authors.forename: L
authors.initials: L
authors.lastname: Handelsman
authors.forename: I S
authors.initials: IS
authors.lastname: Song
authors.forename: M
authors.initials: M
authors.lastname: Losonczy
authors.forename: S
authors.initials: S
authors.lastname: Park
authors.forename: J
authors.initials: J
authors.lastname: Jacobson
authors.forename: J
authors.initials: J
authors.lastname: Wiener
authors.forename: M
authors.initials: M
authors.lastname: Aronson
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000175:diagnosis / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006679:HIV Seropositivity / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008691:Methadone / Q000009:adverse effects; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D008691:Methadone