Cell growth on immobilized cell growth factor. 6. Enhancement of fibroblast cell growth by immobilized insulin and/or fibronectin.
A cell growth factor protein (insulin) and/or a cell-adhesion protein (fibronectin) were immobilized on surface-hydrolyzed poly(methyl methacrylate) membranes. The growth of mouse fibroblast cells STO was accelerated by the immobilized insulin. This acceleration was enhanced by introduction of spacer arms. Coimmobilization of insulin and fibronectin was very effective for the acceleration of cell growth.
Ito
Y
Y
Department of Polymer Chemistry, Faculty of Engineering, Kyoto University, Japan.
Inoue
M
M
Liu
S Q
SQ
Imanishi
Y
Y
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology*; D005353:Fibronectins / Q000493:pharmacokinetics / Q000494:pharmacology*; D007328:Insulin / Q000493:pharmacokinetics / Q000494:pharmacology*; D008768:Methylmethacrylates; D051379:Mice
D001672:Biocompatible Materials; D005353:Fibronectins; D007328:Insulin; D008768:Methylmethacrylates