The outer membranes of Brucella spp. are not barriers to hydrophobic permeants.
The patterns of susceptibility to hydrophobic and hydrophilic drugs and the uptake of the fluorescent probe N-phenyl-naphthylamine in Brucella spp., Haemophilus influenzae, Escherichia coli, and deep rough Salmonella minnesota mutants were compared. The results show that the outer membranes of smooth and naturally rough Brucella spp. do not represent barriers to hydrophobic permeants and that this absence of a barrier relates at least in part to the properties of Brucella lipopolysaccharide.
Martínez de Tejada
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G
Departamento de Microbiología, Universidad de Navarra, Pamplona, Spain.
Moriyón
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I
D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000378:metabolism; D002002:Brucella / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D002463:Cell Membrane Permeability; D004926:Escherichia coli / Q000502:physiology; D006193:Haemophilus influenzae / Q000502:physiology; D008070:Lipopolysaccharides / Q000378:metabolism; D012475:Salmonella / Q000502:physiology
D008070:Lipopolysaccharides; C005444:N-phenyl-1-naphthylamine; D015057:1-Naphthylamine