c-MYC repression of promoter activity through core promoter elements.
c-MYC was found to repress expression of the c-myc promoter in a transient assay system. Deletion constructs showed the cis-acting element(s) were common to both the P1 and P2 promoters. Further analysis involving replacement of the P2 TATA box and initiator elements with the SV40 late promoter initiator localized the cis-acting elements to the core promoter.
Lucas
J M
JM
Department of Hematology and Oncology, Ohio State University Hospital, Columbus.
Wilkie
N M
NM
Lang
J C
JC
D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D016274:Oncogene Protein p55(v-myc) / Q000494:pharmacology*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000494:pharmacology*; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D012097:Repressor Proteins / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D016274:Oncogene Protein p55(v-myc); D016271:Proto-Oncogene Proteins c-myc; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins