Interaction between ultraviolet A and ultraviolet B radiations in skin cancer induction in hairless mice.
The rate of tumor induction by UV-A radiation rises more slowly with time and accumulated dose than that by UV-B radiation. It has recently been shown that this difference disappears when frank papillomas are excluded from the analysis. Thus, the rate of development of "nonpapillomas" (mainly squamous cell carcinomas and precursors) can be fully characterized by a typical tumor induction time, e.g., the time until 50% of the mice bear tumors. This has opened the possibility to investigate how UV-A and UV-B exposures add up in the induction of squamous cell carcinomas, which is an important issue in risk assessments of artificial UV-A sources for cosmetic or medical purposes. We present the results of an experiment in which 6 groups of 24 albino SKH:HR1 mice were treated daily for 600 days with either effective UV-A radiation, effective UV-B radiation, or combinations of both. The observed times it took for 50% of the mice to bear tumors in the combination groups were compared with those calculated on the basis of arithmetical addition of effective UV-A and effective UV-B doses. We did not find a statistically significant (P < 0.05) deviation from additivity.
Berg
R J
RJ
Institute of Dermatology, University Hospital Utrecht, The Netherlands.
de Gruijl
F R
FR
van der Leun
J C
JC
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010212:Papilloma / Q000209:etiology; D012878:Skin Neoplasms / Q000209:etiology*; D014466:Ultraviolet Rays