title: Comparison of humoral immune responses to trivalent influenza split vaccine in young, middle-aged and elderly people.
abstract: A total of 296 volunteers in five different groups were immunized with one dose of the commercial 1991-1992 trivalent split influenza vaccine formulation A/Singapore/6/86 (H1N1), A/Beijing/353/89 (H3N2) and B/Yamagata/16/88. The groups differed in age (young adults, middle-aged and elderly) and history of previous vaccination. Antibodies were determined in pre- and postvaccination sera by haemagglutination inhibition assay and the results were evaluated as geometric mean titre, mean fold antibody increase, protection and response rates. No significant age-related differences among the protection rates were found. The proportion of vaccinees with antibodies > or = 40 ranged between 70 and 95%. Compared with the H3N2 and B components the antibody response to the H1N1-component was low. Residents of a nursing home fully vaccinated the previous year developed 7.6-8.4-fold antibody increases and showed 96-100% protection rates.
authors.affiliation: Robert Koch-Institute, Department Schöneweide, Federal Health Office, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Glathe
authors.forename: S
authors.initials: S
authors.lastname: Bigl
authors.forename: A
authors.initials: A
authors.lastname: Grosche
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000914:Antibodies, Viral / Q000096:biosynthesis*; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines