title: Disseminated infection with Trichosporon beigelii. Report of a case and review of the cutaneous and histologic manifestations.
abstract: BACKGROUND
  Trichosporonosis is a potentially life-threatening disseminated infection with Trichosporon beigelii, the causative agent of the white piedra. Systemic infection by this fungus has been most frequently described in immunocompromised hosts with neutropenia, but one case has been reported in the acquired immunodeficiency syndrome setting. We report a second case of trichosporonosis in a patient with acquired immunodeficiency syndrome and review the clinical and histologic characteristics of cutaneous involvement with this opportunistic fungal pathogen.
  
  
  METHODS
  Trichosporonosis occurs most commonly in neutropenic patients receiving chemotherapy. We describe the second case developing in the acquired immunodeficiency syndrome setting. Cutaneous involvement occurred in approximately 30% of patients and most frequently presented as purpuric papules and nodules with central necrosis or ulceration. Biopsy specimens of these lesions revealed dermal invasion by fungal elements, and culture was positive in greater than 90% of the cases.
  
  
  CONCLUSIONS
  Disseminated infection with T beigelii can occur in immunosuppressed patients, including those with acquired immunodeficiency syndrome particularly if associated with neutropenia. Cutaneous involvement is common, presenting as purpuric papules and nodules. Biopsy and culture of cutaneous findings can help establish an accurate diagnosis resulting in rapid and appropriate treatment.
authors.affiliation: Department of Internal Medicine, University Medical Center, St. Louis, Mo.
authors.forename: G T
authors.initials: GT
authors.lastname: Nahass
authors.forename: S P
authors.initials: SP
authors.lastname: Rosenberg
authors.forename: C L
authors.initials: CL
authors.lastname: Leonardi
authors.forename: N S
authors.initials: NS
authors.lastname: Penneys
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D000328:Adult; D003881:Dermatomycoses / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008297:Male; D012514:Sarcoma, Kaposi / Q000209:etiology; D012536:Scalp Dermatoses / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D014250:Trichosporon