title: Application of X-ray crystallographic methods in the design of purine nucleoside phosphorylase inhibitors.
authors.affiliation: Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853.
authors.forename: S E
authors.initials: SE
authors.lastname: Ealick
authors.forename: Y S
authors.initials: YS
authors.lastname: Babu
authors.forename: C E
authors.initials: CE
authors.lastname: Bugg
authors.forename: M D
authors.initials: MD
authors.lastname: Erion
authors.forename: W G
authors.initials: WG
authors.lastname: Guida
authors.forename: J A
authors.initials: JA
authors.lastname: Montgomery
authors.forename: J A
authors.initials: JA
authors.lastname: Secrist
mesh_terms: D001665:Binding Sites; D003196:Computer Graphics; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: D004791:Enzyme Inhibitors; D011683:Purine-Nucleoside Phosphorylase