title: The effect of high or low dietary calcium on bone and calcium homeostasis in young male rats.
abstract: Young male rats (100 g body weight) were fed diets containing varying amounts of calcium. Body weight and bone development were studied together with various endocrine parameters, including blood levels of Ca2+, calcitonin, parathyroid hormone, vitamin D, and gastrin, and the enterochromaffin-like (ECL) cell-related parameters gastric mucosal histidine decarboxylase activity and histamine concentration. A diet containing 0.5% calcium resulted in optimum body weight gain and bone development. A lower calcium intake impaired body weight gain and bone development. The impairment was manifested in reduced bone calcium content whereas the size of the bones was unaffected. The net absorption of calcium seemed to be proportional to the calcium intake. A low calcium diet (0.03%) raised the circulating levels of 1,25(OH)2D and parathyroid hormone and lowered 25(OH)D3 and Ca2+, whereas a high calcium diet (5.46%) raised calcitonin, Ca2+, 25(OH)D3, and 1,25(OH)2D. In addition, the low calcium diet lowered the circulating gastrin concentration and the histidine decarboxylase activity and histamine content of the ECL cells in the gastric mucosa. A high calcium diet raised the circulating gastrin concentration, but the rise was not associated with an increase in the histidine decarboxylase activity and histamine content.
authors.affiliation: Department of Pharmacology, University of Lund, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Persson
authors.forename: R
authors.initials: R
authors.lastname: Gagnemo-Persson
authors.forename: R
authors.initials: R
authors.lastname: Håkanson
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D004759:Enterochromaffin Cells / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D005755:Gastrins / Q000097:blood; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014807:Vitamin D / Q000097:blood
chemical_list: D002136:Calcium, Dietary; D005755:Gastrins; D014807:Vitamin D; D002116:Calcitonin; D002118:Calcium