title: Hormonal regulation of human testicular inhibin alpha and beta B subunit messenger RNAS.
abstract: Changes in messenger ribonucleic acids (mRNAs) of human testicular inhibin alpha and beta B subunits induced by human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) were assessed in vivo and in vitro. After a single administration of hMG, inhibin alpha mRNA in the human testis significantly increased, whereas inhibin beta B mRNA remained unchanged. Administration of hCG induced a slight increase in inhibin alpha mRNA without affecting inhibin beta B mRNA. In experiments in vitro using the testicular organ culture technique, an exposure to hMG for 24 hours induced a dose-related significant increase in inhibin alpha mRNA. Inhibin beta B mRNA was not affected by either hCG or hMG exposure. These results indicate that luteinizing hormone (hCG) as well as follicle stimulating hormone (hMG) may play a role in the regulation of human testicular inhibin alpha mRNA, although the mechanism of the LH action is not clear.
authors.affiliation: Department of Urology, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Namiki
authors.forename: N
authors.initials: N
authors.lastname: Kondoh
authors.forename: K
authors.initials: K
authors.lastname: Matsumiya
authors.forename: S
authors.initials: S
authors.lastname: Sakoda
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimune
authors.forename: A
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D000328:Adult; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007265:Inhibins / Q000235:genetics*; D007986:Luteinizing Hormone / Q000502:physiology*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis*; D013737:Testis / Q000502:physiology*
chemical_list: D012333:RNA, Messenger; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone