[The anti-arrhythmic action of exogenous creatine phosphate and its effect on myocardial electrophysiological parameters in acute heart failure].
The experiments on rats with overload heart failure have shown that creatine phosphate (CP) used in a single dose at the peak of severe signs of cardiac decompensation was found to produce a short-term normalization of rhythm and an increase in heart rate. With multiple doses, the agent slowed down the development of bradycardia, prevented arrhythmias and promoted the rise of longevity in the experimental animals. At the same time, exogenous CP failed to affect energy-dependent processes of re- and depolarization which were impaired in the myocardium in acute heart failure.
Khanina
N Ia
NIa
Savel'ev
V A
VA
Vikulova
O V
OV
D000208:Acute Disease; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D004594:Electrophysiology; D004734:Energy Metabolism / Q000187:drug effects; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D010725:Phosphocreatine / Q000627:therapeutic use*; D051381:Rats
D000889:Anti-Arrhythmia Agents; D010725:Phosphocreatine
Antiaritmicheskoe deĭstvie ékzogennogo kreatinfosfata i ego vliianiia na élektrofiziologicheskie parametry miokarda pri ostroĭ serdechnoĭ nedostatochnosti.