title: Neuropsychological and neurophysiological assessment of the central effects of interleukin-2 administration.
abstract: Neuropsychiatric disturbances may occur following interleukin-2 (IL2) administration. We studied the effects of IL2 infusion on cerebral functions in 7 patients with neuropsychological tests and event-related evoked potentials (P300). We observed a failure in the cognitive performances, an increase in latency, and a decrease in amplitude of P300. These effects followed IL2 administration and were reversible.
authors.affiliation: Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caraceni
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: F
authors.initials: F
authors.lastname: Belli
authors.forename: L
authors.initials: L
authors.lastname: Mascheroni
authors.forename: L
authors.initials: L
authors.lastname: Rivoltini
authors.forename: F
authors.initials: F
authors.lastname: Arienti
authors.forename: N
authors.initials: N
authors.lastname: Cascinelli
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000139:chemically induced*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D008545:Melanoma / Q000503:physiopathology / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects; D011994:Recombinant Proteins / Q000009:adverse effects
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins