[Activities of antibiotics against methicillin-resistant Staphylococcus aureus with particular reference to synergetic effect between ticarcillin and fosfomycin on penicillinase non-producing methicillin-resistant S. aureus].
We tested susceptibilities of 46 strains of clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) to arbekacin (ABK), tobramycin (TOB), ticarcillin (TIPC), clavulanic acid/ticarcillin (CVA/TIPC) and fosfomycin (FOM). Twelve strains had penicillinase activity. Most strains were resistant to TOB, TIPC, FOM and CVA/TIPC, but ABK inhibited 80% of the 46 MRSA strains at a concentration of 1.56 microgram/ml. The combination of ABK and FOM was indifferent. Synergism was observed, however, between FOM and TIPC against 79% of penicillinase non-producing MRSA. This synergism may mean that FOM inhibits the production of penicillin-binding protein 2' in some strains of penicillinase non-producing MRSA.
Morikawa
Y
Y
Department of Pediatrics, Yodogawa Christian Hospital.
Yoshioka
Y
Y
Toshima
M
M
D001426:Bacterial Proteins; D002352:Carrier Proteins; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D005578:Fosfomycin / Q000494:pharmacology*; D006602:Hexosyltransferases / Q000096:biosynthesis; D006801:Humans; D016106:Methicillin Resistance; D009097:Multienzyme Complexes / Q000096:biosynthesis; D002267:Muramoylpentapeptide Carboxypeptidase; D046915:Penicillin-Binding Proteins; D010405:Penicillinase / Q000378:metabolism; D010458:Peptidyl Transferases / Q000096:biosynthesis; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology; D013982:Ticarcillin / Q000494:pharmacology*
D001426:Bacterial Proteins; D002352:Carrier Proteins; D009097:Multienzyme Complexes; D046915:Penicillin-Binding Proteins; D005578:Fosfomycin; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D010405:Penicillinase; D013982:Ticarcillin