title: [Load of autosomal recessive diseases in populations of Kirov Province and its relationship to consanguinity].
abstract: The dependence of the load of autosomal recessive disorders on a variation of random inbreeding in the populations of the 9th Districts of the Kirov Province was investigated. The values of the Fst varied between different districts from 0.00021 to 0.0011 and the values of load of AR--from 0.73 to 2.01 affected per 1000. There is a close significant correlation (r = 0.90) between the parameters in the population studied which increased under analysis of the population considering the coefficients of random inbreeding.
authors.forename: E K
authors.initials: EK
authors.lastname: Ginter
authors.forename: R A
authors.initials: RA
authors.lastname: Memdova
authors.forename: G I
authors.initials: GI
authors.lastname: El'chinova
authors.forename: O V
authors.initials: OV
authors.lastname: Brusintseva
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kadoshnikova
authors.forename: N V
authors.initials: NV
authors.lastname: Petrova
authors.forename: A M
authors.initials: AM
authors.lastname: Bukina
authors.forename: A M
authors.initials: AM
authors.lastname: Alalykin
mesh_terms: D003241:Consanguinity; D005260:Female; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D008297:Male; D012426:Russia
vernacular_title: Otiagoshchennost' autosomno-retsessivnoĭ patologieĭ populiatsiĭ Kirovskoĭ oblasti i ee sviaz' inbridingom.