Comparative bioavailability study of acetaminophen solutions used in hospital formulary.
To learn the influence of polyethylene glycol (PEG) on bioavailability, this study compared the bioavailability of acetaminophen in the presence of 10% ethanol (acetaminophen-ethanol liquid) to that in the presence of 10% PEG (acetaminophen-PEG liquid) since these two preparations are commonly used in hospital formulary. The results in Thai male volunteers showed there was not significantly different.
Prakongpan
S
S
Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Puncoke
R
R
Nagai
T
T
D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol; D005572:Formularies, Hospital as Topic; D006801:Humans; D008297:Male; D011092:Polyethylene Glycols; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
D012996:Solutions; D000082:Acetaminophen; D000431:Ethanol; D011092:Polyethylene Glycols