title: An evaluation of pre- and postoperative nonsteroidal antiinflammatory drugs in patients undergoing knee arthroscopy. A prospective, randomized, double-blinded study.
abstract: The potential benefits of a nonsteroidal antiinflammatory drug to 67 patients undergoing knee arthroscopy were evaluated in a prospective, randomized, placebo-controlled, double-blinded study. Group A received the drug (diclofenac, 75 mg twice daily) for 3 to 5 days before and for 7 days after surgery. Group B received a placebo preoperatively and the drug postoperatively. Group C received a placebo at both times. Codeine was available postoperatively for all patients if needed. Outcomes reported by the subjects included pain, crutch use, and return to activities. Outcomes assessed by physicians included knee effusion, range of motion, and gait. Knee flexion and extension strengths were measured isokinetically pre- and postoperatively. Pain scores on the 1st postoperative day were higher in Group C than in Group A. Pain scores at all other time points were not significantly different in the three treatment groups. Groups A and B required less codeine during the first 72 hours after surgery than Group C (mean, 2.9 +/- 1.0 versus 6.8 +/- 1.0 pills). Recovery of function, recovery of strength, and physical examination parameters were not significantly different in the three treatment groups. Diclofenac was an effective analgesic in the immediate postoperative period. Recovery from arthroscopy, however, was not enhanced by taking the drug.
authors.affiliation: Division of Orthopaedic Surgery, University of North Carolina, Chapel Hill 27599-7055.
authors.forename: W E
authors.initials: WE
authors.lastname: Nelson
authors.forename: R C
authors.initials: RC
authors.lastname: Henderson
authors.forename: L C
authors.initials: LC
authors.lastname: Almekinders
authors.forename: R A
authors.initials: RA
authors.lastname: DeMasi
authors.forename: T N
authors.initials: TN
authors.lastname: Taft
mesh_terms: D000293:Adolescent; D000328:Adult; D001182:Arthroscopy; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000502:physiology; D010149:Postoperative Pain / Q000188:drug therapy*; D011292:Premedication; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D004008:Diclofenac