Postoperative gastroparesis and tachygastria--response to electric stimulation and erythromycin.
BACKGROUND
The purpose of this study was to correlate clinical course, gastric emptying, and gastric myoelectric activity in a patient after gastric operation and to determine the effect of electric stimulation and the administration of erythromycin on the patient's gastric rhythm.


METHODS
Daily myoelectric recordings were obtained through implanted gastric electrodes after truncal vagotomy and gastroenterostomy for an obstructing duodenal ulcer.


RESULTS
The patient had acute postoperative delayed gastric emptying, accompanied initially by stomal edema but subsequently associated with persistent tachygastria. The gastric rhythm was only transiently slowed by multiple attempts at electroversion but appeared to respond dramatically to intravenous erythromycin therapy. Although delayed gastric emptying persisted on radionuclide gastric emptying studies, the patient slowly improved clinically with continued erythromycin therapy.


CONCLUSIONS
Disturbances in gastric rhythm may accompany postoperative gastroparesis, although in our patient the dysrhythmias appeared to occur secondary to gastric outlet obstruction. Although his stomach could be paced, pacing was not effective in restoring a normal gastric rhythm. In contrast, intravenous erythromycin therapy was associated with rapid restoration of a normal gastric rhythm and slow improvement in gastric function.
Hocking
M P
MP
Department of Surgery, University of Florida College of Medicine, Gainesville.
D000714:Anastomosis, Surgical; D004558:Electric Stimulation; D004917:Erythromycin / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects; D017219:Gastric Outlet Obstruction / Q000209:etiology / Q000601:surgery*; D005763:Gastroenterostomy; D006801:Humans; D007583:Jejunum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology* / Q000601:surgery; D013276:Stomach Ulcer / Q000150:complications / Q000601:surgery; D014628:Vagotomy
D004917:Erythromycin