The mouse iduronate sulfatase gene: identification of a novel transcript.
Complementary DNAs, cDNAs, coding for iduronate sulfatase (IDS, E.C.3.1.6.13) have been isolated and characterized in man and mouse. The murine cDNA (MTA16) was highly homologous to the human counterpart. By screening the same mouse thymus cDNA library another cDNA (MTA13) was isolated: it is 1831 bp long and is identical to a part of the MTA16 cDNA in its 5' region, but it is completely divergent in the 3' region. Characterization of the MTA13 mRNA as well as its genomic organization are presented. The results herein reported support the hypothesis that MTA13 and MTA16 mRNAs are encoded by the same gene.
Daniele
A
A
Dipartimento di Biochimica e Biotechnologie Mediche Medical School, University of Naples Federico II, Italy.
Russo
T
T
Ballabio
A
A
Di Natale
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D007066:Iduronate Sulfatase / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013950:Thymus Gland; D014158:Transcription, Genetic
D012333:RNA, Messenger; D007066:Iduronate Sulfatase