Photosensitization with methylene-linked porphyrin dimers.
The photodynamic therapy (PDT) efficacy of a series of porphyrin dimers linked by methylene groups was evaluated using the radiation-induced fibrosarcoma (RIF) tumor model. Longer chain length led to greater efficacy and increased dimer hydrophobicity. This result was correlated with the persistence of porphyrins in plasma, but not with tissue levels.
Kessel
D
D
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201.
Chang
C K
CK
Henderson
B W
BW
D000818:Animals; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D008833:Microcirculation / Q000187:drug effects; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000633:toxicity; D012867:Skin / Q000098:blood supply; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D017319:Photosensitizing Agents; D011166:Porphyrins