99mTc-antimyosin antibody imaging for the detection of acute myocardial infarction in human beings.
111In-antimyosin imaging is a highly sensitive and specific technique for the detection of myocardial necrosis. Two new methods of labeling antimyosin with 99mTc have been developed, and were compared with the standard 111In-antimyosin imaging technique in 29 patients with acute myocardial infarction. Fourteen patients (group I) received directly labeled 99mTc-antimyosin, and 15 (group II) were given RP-1 conjugated 99mTc-antimyosin. 99mTc-antimyosin imaging was performed at 6, 12, and 24 hours, and 111In-antimyosin imaging was done at 24 and 48 hours following injection. The images were interpreted by three blinded observers. In group I, 99mTc-antimyosin uptake could be detected in 3, 6, and 12 cases at 6, 12, and 24 hours, respectively, compared with only 8 cases at 24 hours with 111In-antimyosin. At 48 hours all patients showed 111In-antimyosin uptake. In group II, 99mTc-antimyosin uptake could be detected in 2, 3, and 6 cases at 6, 12, and 24 hours, respectively, compared with 8 and 12 cases at 24 and 48 hours, respectively, with 111In-antimyosin. Gated blood pool studies could be obtained in all patients following 99mTc-antimyosin injection and could be used to identify regional wall motion abnormalities. The plasma half-lives of 99mTc-antimyosin in group I and group II were 2.67 +/- 0.3 hours and 4.23 +/- 0.3 hours, respectively, and the plasma half-life of 111In-antimyosin was 6.3 +/- 0.4 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
Senior
R
R
Department of Cardiology, Northwick Park Hospital, Harrow, Middlesex, United Kingdom.
Bhattacharya
S
S
Manspeaker
P
P
Liu
X J
XJ
Leppo
J A
JA
Lahiri
A
A
D000368:Aged; D000911:Antibodies, Monoclonal / Q000097:blood; D016009:Chi-Square Distribution; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000379:methods; D006207:Half-Life; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007205:Indium Radioisotopes / Q000097:blood; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology; D009218:Myosins / Q000276:immunology; D009942:Organometallic Compounds / Q000097:blood; D015609:Organotechnetium Compounds / Q000097:blood; D012044:Regression Analysis; D013997:Time Factors
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C082980:technetium Tc99m-antimyosin; C058899:imciromab pentetate; D009218:Myosins