[Sensitivity of chlorpromazine-modified eryhtrocytes to cold stress].
Development peculiarities of hypertonic cold shock of erythrocytes modified with chlorpromazine were studied, maximum protection effect under cooling of cells is registered when using chlorpromazine in the concentration 7 x 10(-5) M. Spectrin denaturation does not change general pattern of the effect of different concentrations of amphipat on sensitivity of erythrocytes to the cold shock but it sensitizes cells modified by chlorpromazine (7 x 10(-5) M) to the further cooling. Differences between native cells and erythrocytes with denatured spectrin are levelled at higher concentrations of amphypat, certain protective effect being observed at certain values of the medium tonicity.
Shpakova
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LV
D002746:Chlorpromazine / Q000494:pharmacology*; D003080:Cold Temperature; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D011489:Protein Denaturation; D012462:Saline Solution, Hypertonic; D012769:Shock / Q000097:blood*; D013049:Spectrin / Q000737:chemistry
D012462:Saline Solution, Hypertonic; D013049:Spectrin; D002746:Chlorpromazine
Chuvstvitel'nost' modifitsirovannykh khlorpromazinom éritrotsitov k kholodovomu shoku.