Effects of some cephalosporins and teicoplanin on platelet aggregation.
Antibiotics may interfere with platelet (PLT) function, and beta-lactam antibiotics may interact with PLT aggregation, by inhibiting the binding of agonists of this aggregation (such as ADP and collagen) to specific receptor sites. In this study we have evaluated the relative in-vitro antiplatelet effects of some old and new cephalosporins (cefonicid, ceftazidime, ceftriaxone, cefotaxime, cefuroxime and flomoxef) and of teicoplanin, a new glycopeptide antibiotic. All the cephalosporins tested, and also teicoplanin, were found to have the potential to adversely affect human platelet aggregation only at high concentrations which are not achieved in vivo.
Cazzola
M
M
Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, Second University of Naples, Italy.
Matera
M G
MG
Santangelo
G
G
Lampa
E
E
Angrisani
M
M
Loffreda
A
A
Rossi
F
F
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects; D002511:Cephalosporins / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D017334:Teicoplanin / Q000494:pharmacology*
D002511:Cephalosporins; D010975:Platelet Aggregation Inhibitors; D017334:Teicoplanin; D000244:Adenosine Diphosphate; D003094:Collagen