Anti-Mlsa-like effect of CBA/J anti DBA2 antibody in in vitro MLRs between Mls incompatible combinations.
Antisera from CBA/J (H-2k,Mlsa) mice hyperimmunised with DBA2 (H-2d,Mlsa) and/or AKR (H-2k,Mlsa) splenocytes, can block in vitro MLRs against Mlsa determinants. These two antisera are furthermore specifically cytotoxic against targets expressing H-2 components but not against Mlsa-bearing targets. In these experimental models the anti-Mlsa-like effects of CBA/J anti-DBA2 and CBA/J anti AKR antibodies seem to be associated with an autoreactive immune response in CBA/J mice elicited by DBA2 and AKR splenocytes, respectively. In this report we propose that anti-Mlsa antibodies can also be generated in a situation in which Mlsa is presented as 'altered self' in conjunction with allo-determinants.
De Giorgi
L
L
Immunology Department, Rayne Institute, St Thomas' Hospital, London, UK.
De Matos
C
C
Matossian-Rogers
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D064532:Histocompatibility Antigen H-2D; D007114:Immunization; D007518:Isoantibodies / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA / Q000235:genetics / Q000276:immunology*; D008811:Mice, Inbred DBA / Q000235:genetics / Q000276:immunology*; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D016747:Minor Lymphocyte Stimulatory Antigens / Q000235:genetics / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D007518:Isoantibodies; D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta