title: In vivo kinetics of oxidatively modified HDL.
abstract: The kinetics of oxidatively modified high-density lipoprotein (HDL) in vivo were investigated. 125I-labeled oxidized (Ox) HDL and 131I-labeled native (N) HDL were injected simultaneously into control and WHHL rabbits. The fractional catabolic rates of 125I-labeled Ox-HDL were significantly greater than those of 131I-labeled N-HDL in both control (2.52 +/- 0.36/day vs 0.94 +/- 0.02/day) and WHHL rabbits (4.07/day vs 1.32/day). Oxidized HDL was catabolized faster than native HDL and was taken up primarily by the liver, spleen, and kidney.
authors.forename: R
authors.initials: R
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Saku
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: M
authors.initials: M
authors.lastname: Shiomi
authors.forename: K
authors.initials: K
authors.lastname: Arakawa
mesh_terms: D000818:Animals; D007668:Kidney / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits; D013154:Spleen / Q000378:metabolism
chemical_list: D008075:Lipoproteins, HDL