title: The carbamate insecticide ZZ-Aphox induced structural changes of gills, liver, gall-bladder, heart, and notochord of Rana perezi tadpoles.
abstract: Embryos of Rana perezi were kept under laboratory conditions and treated with carbamate ZZ-Aphox at chronic doses of 0.02% and 0.14% for 9 weeks. Both the histological study and the analysis of mortality show a direct relationship between the dosage and the effects of the pesticide. The histological study of the survivors over 56 days show damages in gills, liver, gall-bladder, heart, and notochord. Damages on the epithelial of gills (on their distal portion) and gall-bladder recover over a few days, whereas those provoked on the compacting of the hepatic parenchyma and the hepatocytes, the auricle and the perintocohordal collagenic fibers alter their structure in a lasting way. Potentials of such alterations are discussed, with special reference to the possible interference of the pesticide on the successful synthesis of the supporting connective sheaths.
authors.affiliation: Dpto. Biología Celular y Anatomía, Universidad de León, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pilar Honrubia
authors.forename: M
authors.initials: M
authors.lastname: Paz Herráez
authors.forename: R
authors.initials: R
authors.lastname: Alvarez
mesh_terms: D000818:Animals; D002219:Carbamates / Q000633:toxicity*; D005704:Gallbladder / Q000187:drug effects / Q000473:pathology*; D007814:Larva / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D009672:Notochord / Q000187:drug effects / Q000473:pathology*; D011743:Pyrimidines; D011898:Ranidae; D015996:Survival Rate
chemical_list: D002219:Carbamates; D011743:Pyrimidines; C011994:pirimicarb