title: Silver acetate mouth spray as an aid in smoking cessation: results of a double-blind trial.
abstract: BACKGROUND
  We studied the use of an aversive technique to improve the outcome of smoking-cessation efforts. We hypothesized that a silver acetate mouth spray, which produces a strong aversive taste when cigarettes are smoked, would increase the quit rate among smokers.
  
  
  METHODS
  Our study was a double-blind, placebo-controlled trial that was carried out in a private family practice office in an urban area. We studied 42 smokers, who were recruited by advertisement and who were motivated to quit by self-report. They were randomly assigned active spray or placebo spray; all were given a written list of behavioral suggestions. The spray was to be used every 2 hours for 3 weeks during which time the subjects were to keep diaries of cigarette smoking and spray use. Biochemical measures (salivary thiocyanate and cotinine) were recorded at entry, at 3 weeks, and at 3 months.
  
  
  RESULTS
  Thirty smokers completed the study. No differences were found between the two groups in quit rate or number of cigarettes smoked.
  
  
  CONCLUSIONS
  Silver acetate aversive spray did not increase quit rate among motivated smokers.
authors.affiliation: Department of Family Medicine, St. Joseph's Medical Center, Yonkers, NY.
authors.forename: R
authors.initials: R
authors.lastname: Morrow
authors.forename: P
authors.initials: P
authors.lastname: Nepps
authors.forename: M
authors.initials: M
authors.lastname: McIntosh
mesh_terms: D000085:Acetates / Q000008:administration & dosage*; D019342:Acetic Acid; D000336:Aerosols; D001348:Aversive Therapy / Q000379:methods*; D004311:Double-Blind Method; D005194:Family Practice; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D009055:Mouth; D010865:Pilot Projects; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology
chemical_list: D000085:Acetates; D000336:Aerosols; D019342:Acetic Acid