title: Induced resistance and susceptibility to cerebral ischemia in gerbil hippocampal neurons by prolonged but mild hypoperfusion.
abstract: Brief periods of non-lethal cerebral ischemia can induce resistance against subsequent lethal ischemia. In this study, asymptomatic gerbils after unilateral carotid artery ligation were subjected to 5 min of forebrain ischemia. The prolonged but mild hypoperfusion, by carotid occlusion, induced susceptibility at 1 day and tolerance at 30 days to lethal ischemia in the hippocampal neurons. The neuroprotective effect correlated well with induction of heat shock protein 72 in the hippocampal neurons. These results suggested that neuronal cells possess a cellular response to sublethal hypoperfusion and can survive forthcoming ischemic stress.
authors.affiliation: First Department of Internal Medicine, Osaka University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Kitagawa
authors.forename: A
authors.initials: A
authors.lastname: Taguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: R
authors.initials: R
authors.lastname: Hata
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Ueda
authors.forename: N
authors.initials: N
authors.lastname: Handa
authors.forename: T
authors.initials: T
authors.lastname: Kamada
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002339:Carotid Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005849:Gerbillinae; D006360:Heat-Shock Proteins / Q000276:immunology / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006651:Histocytochemistry; D015151:Immunoblotting; D002546:Ischemic Attack, Transient / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009474:Neurons / Q000502:physiology*
chemical_list: D006360:Heat-Shock Proteins