[Severe bone malformations in fetal valproic acid disease].
The dysmorphogenic and teratogenic effects of valproic acid, when administered to pregnant women, have been noted in several reports. We report the case of a 3-month-old infant with multiple congenital anomalies, including severe skeletal malformations, congenital heart defect and facial dysmorphism, whose mother was treated with valproic acid (1000 mg/day) throughout the pregnancy. This is the second published case reporting major skeletal malformations and supports the possible teratogenic effects of valproic acid.
Lorenzo Sanz
G
G
Sección de Neuropediatría, Hospital Ramón y Cajal, Madrid.
Serna Saugar
C
C
Quintana Castilla
A
A
Lozano Giménez
C
C
Aparicio Meix
J M
JM
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D001842:Bone and Bones / Q000002:abnormalities*; D005145:Face / Q000002:abnormalities*; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects*
D014635:Valproic Acid
Malformaciones esqueléticas severas en la fetopatía por ácido valproico.