title: The effects of aging on diurnal water intake and melatonin binding in the suprachiasmatic nucleus.
abstract: In vitro autoradiography was used to quantify [125I]melatonin binding in young rats and in aged rats that were screened for diurnal drinking prior to neurobiological study. Among the aged subjects studied, some rats exhibited a blunted diurnal rhythm in that a decreased percentage of water was consumed during the dark phase. Other aged animals maintained a strong nocturnal pattern of water intake similar to young rats. The density of [125I]melatonin binding in the suprachiasmatic nucleus (SCN) of the hypothalamus was significantly correlated with diurnal drinking, i.e. lower binding was associated with a more blunted rhythm. Thus, [125I]melatonin binding in the SCN may provide a marker for age-related decline in some aspects of biological functions.
authors.affiliation: Department of Psychology, University of North Carolina, Chapel Hill 27599.
authors.forename: J M
authors.initials: JM
authors.lastname: Whealin
authors.forename: R D
authors.initials: RD
authors.lastname: Burwell
authors.forename: M
authors.initials: M
authors.lastname: Gallagher
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002940:Circadian Rhythm / Q000502:physiology*; D004326:Drinking / Q000502:physiology*; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D051381:Rats; D013493:Suprachiasmatic Nucleus / Q000033:anatomy & histology / Q000378:metabolism*
chemical_list: D008550:Melatonin