[Change of right ventricle performance caused by intravenous nitroglycerin infusion in patients with isolated mitral stenosis].
The impact of intravenous infusion of nitroglycerin (NTG) on the conditions of the right ventricle (RV) load was assessed in a group of 27 patients with isolated mitral stenosis (SM). Swan-Ganz catheter was used to assess the parameters influencing preload and afterload of the RV at rest and during effort of its performance under NTG. NTG infusion caused lowering of RV filling pressure at rest (from 5.1 +/- 2.8 to 3.2 +/- 1.9 mm Hg, p < 0.001), and during effort (from 7.6 +/- 3.6 to 4.9 +/- 2.2 mg Hg, p < 0.001), lowering of mean pulmonary artery pressure at rest (from 27 +/- 10.7 to 19.8 +/- 9.2 mm Hg, p < 0.001) and during effort (from 48.6 +/- 15.5 to 39.4 +/- 16.1 mm Hg, p < 0.001), and lowering of capillary wedge pressure at rest (from 17.1 +/- 6.9 to 12.7 +/- 6.2 mm Hg, p < 0.001) and during effort (from 32.9 +/- 10.1 to 25.9 +/- 8.4 mm Hg, p < 0.001). NTG infusion lowers pulmonary vascular resistance at rest (from 2.5 +/- 1.6 to 1.9 +/- 1.5 W.u., p < 0.001) and during effort (from 2.9 +/- 2.0 to 2.4 +/- 1.9 W.u., p < 0.001). NTG causes beneficial lowering of the stroke work index of the RV at rest (from the average of 9.9 +/- 5.3 to the average of 6.4 +/- 3.9 pm/m2, p < 0.001) and during effort (from the average of 19.1 +/- 9.1 to the average of 15.7 +/- 9.0 pm/m2, p < 0.001). Beneficial hemodynamic effect of NTG on preload and afterload of the RV in patients with isolated SM was demonstrated.
Rajecka
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Instytut Kardiologii Warszawa-Anin.
D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000188:drug therapy*; D005996:Nitroglycerin / Q000008:administration & dosage*; D016278:Ventricular Function, Right / Q000187:drug effects*
D005996:Nitroglycerin
Zmiana warunków obciazenia prawej komory wywołana dozylnym wlewem nitrogliceryny u chorych ze zwezeniem lewego ujścia zylnego.