[Intraperitoneal chemo-hyperthermia in the treatment of peritoneal carcinomatosis of ovarian origin. Initial cases, physiopathologic data].
The authors report the first results using intraperitoneal hyperthermic chemotherapy with mitomycin C or cisplatinum with protective hypothermia up to 32 degrees C in four cases of peritoneal carcinomatosis secondary to cancer of the ovary which was resistant to conventional treatment. They were stage III and IV in the FIGO classification. There were no post-operative complications. Two patients are still alive 4 and 6 months after intraperitoneal hyper-chemotherapy. Hypothermia has its own action of destroying tumour cells and potentiates the effects of chemotherapy. We have, following the work of the japanese, devised a therapeutic regime combining chemotherapy and intraperitoneal hyperthermia.
Salle
B
B
Service de chirurgie B, Centre Hospitalier Lyon Sud, Saint-Genis-Laval.
Gilly
F N
FN
Carry
P Y
PY
Sayag
A
A
Brachet
A
A
Braillon
G
G
D000368:Aged; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D012074:Remission Induction
D016685:Mitomycin; D002945:Cisplatin
Chimio-hyperthermie intrapéritonéale dans le traitement des carcinoses péritonéales d'origine ovarienne. Premières observations, données physiopathologiques.