[Transdermal application of 10% lidocaine-gel for management of pain associated with herpes zoster].
We have developed transdermally applicable 10% lidocaine aqueous gel containing an absorption promoter and applied it for 15 patients suffering from severe pain in acute or subacute phase of herpes zoster. The patients, consisting of 7 males and 8 females with a mean age 58.5 +/- 13.0 (SD) yrs, had skin eruptions of herpes zoster for the past 2 months. Lidocaine-gel was applied locally to the diseased skin with or without an occlusive dressing. In 14 of the 15 patients (93%), a remarkable reduction of pain (below 10% of pretreatment level) was obtained after 9.9 +/- 5.6 (SD) times of lidocaine-gel treatments. There was no adverse systemic reactions or local skin damages. None of them developed post-herpetic neuralgia. The lidocaine-gel treatment appears to be very useful for reduction of pain associated with acute or subacute phase of herpes zoster.
Shimoda
O
O
Department of Anesthesiology, Kumamoto Rosai Hospital, Yatsushiro.
Kano
T
T
Takaki
M
M
Tashima
T
T
Tashiro
M
M
Ikuta
Y
Y
Morioka
T
T
Nakano
M
M
Mishima
M
M
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005782:Gels; D006562:Herpes Zoster / Q000503:physiopathology*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D010146:Pain / Q000188:drug therapy*; D012869:Skin Absorption
D005782:Gels; D008012:Lidocaine