title: Changes in parvalbumin-immunoreactive neurons in the rat hippocampus following a kainic acid lesion.
abstract: Changes in a sub-population of hippocampal non-pyramidal neurons following a unilateral lesion with kainic acid were examined using an antibody raised against the Ca-binding protein parvalbumin. A loss of 71-97% of the parvalbumin-immunoreactive neurons occurred at the three post-lesion times studied (1, 2 and 4 weeks) in all areas of the ipsilateral hippocampus, but no such loss was observed in the dentate gyrus. Resistant parvalbumin-immunoreactive neurons occurred principally in stratum pyramidale and displayed altered morphology from the normal with swollen dendrites and dendritic varicosities. The contralateral hippocampus exhibited losses of parvalbumin-immunoreactive cells, but this was restricted to stratum oriens of CA1. This data demonstrates the loss of a specific and important population of non-pyramidal neurons which might be responsible for the chronic loss of functional inhibition seen in this animal model of temporal lobe epilepsy.
authors.affiliation: Department of Human Morphology, University of Southampton, UK.
authors.forename: N
authors.initials: N
authors.lastname: Best
authors.forename: J
authors.initials: J
authors.lastname: Mitchell
authors.forename: K G
authors.initials: KG
authors.lastname: Baimbridge
authors.forename: H V
authors.initials: HV
authors.lastname: Wheal
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D007158:Immunologic Techniques; D007608:Kainic Acid / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D010320:Parvalbumins; D007608:Kainic Acid