Increased soluble IL-2 receptor in serum of patients with systemic lupus erythematosus.
We estimated the concentration of soluble IL-2R (sIL-2R) in the serum of patients with systemic lupus erythematosus (SLE) and examined the relationship between the serum levels of sIL-2R and clinical features or laboratory data. We found that elevated levels of sIL-2R were present in the serum of SLE patients with discoid rash, and sIL-2R concentrations were correlated with the soluble CD4 and soluble CD8 concentrations but not with classical serological marker, anti-DNA antibody or complement titer.
Sawada
S
S
Department of Internal Medicine, Nerima Hikarigaoka Hospital, Nihon University School of Medicine, Japan.
Hashimoto
H
H
Iijma
S
S
Tokano
Y
Y
Matsukawa
Y
Y
Takei
M
M
Ishikawa
H
H
Kang
H
H
Tomura
K
K
Mitamura
K
K
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D015941:Complement Hemolytic Activity Assay; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008875:Middle Aged; D009994:Osmolar Concentration; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012995:Solubility
D000974:Antibodies, Antinuclear; D015704:CD4 Antigens; D016827:CD8 Antigens; D015375:Receptors, Interleukin-2; D004247:DNA