Rumbrin, a new cytoprotective substance produced by Auxarthron umbrinum. I. Taxonomy, production, isolation and biological activities.
Rumbrin has been isolated from a fungus, Auxarthron umbrinum, by a screening program designed to find microorganism-produced cytoprotective substances. It was purified by use of column chromatography on silica gel, reversed phase HPLC and then isolated as fine red needles. Rumbrin prevented cell death caused by calcium overload and exhibited a potent inhibitory activity against lipid peroxidation.
Yamagishi
Y
Y
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Matsuoka
M
M
Odagawa
A
A
Kato
S
S
Shindo
K
K
Mochizuki
J
J
D000818:Animals; D002121:Calcium Channel Blockers / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D005285:Fermentation; D005658:Fungi / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects*; D051379:Mice; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology; D011758:Pyrroles / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
D002121:Calcium Channel Blockers; D011753:Pyrones; D011758:Pyrroles; C082417:rumbrin