title: Quantification of transpulmonary echocontrast effects.
abstract: Videodensity of left heart and right heart were studied after intravenous injection of increasing dosages of 0.01-0.02 and 0.04 mL/kg bodyweight of Albunex in 10 healthy volunteers. The increase in videodensity in the left ventricle was always lower than in the right ventricle. Possible explanations are diffusion of gases caused by ambient pressures changes and change in microspheres distribution due to the sieving effect of the lung capillary bed. These phenomena were studied in vitro and were consistent with clinical observations. These limitations restrict a quantitative assessment of left heart echocontrast after intravenous injection.
authors.affiliation: Department of Cardiology and Experimental Echocardiography, Thoraxcenter, University Hospital Dijkzigt, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: de Jong
authors.forename: F J
authors.initials: FJ
authors.lastname: ten Cate
authors.forename: W B
authors.initials: WB
authors.lastname: Vletter
authors.forename: J R
authors.initials: JR
authors.lastname: Roelandt
mesh_terms: D000328:Adult; D000418:Albumins; D003287:Contrast Media; D015150:Echocardiography, Doppler / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008863:Microspheres; D010477:Perfusion; D014741:Video Recording
chemical_list: D000418:Albumins; C060687:Albunex; D003287:Contrast Media