title: [High dose intravenous immunoglobulins in therapeutic arsenal in autoimmune and systemic diseases].
abstract: Immune globulin are extracted from plasma pooled from 1000 or more donors. Each lot should contain at least 90% of intact IgG. Intravenous immune globulin are recommended unequivocally for some diseases: acute autoimmune thrombocytopenic purpura of childhood, autoimmune erythroblastopenia, haemophilia with anti-VIII antibodies, Kawasaki's syndrome, and perhaps, Guillain-Barré syndrome. Nevertheless, this therapy has been reported to be beneficial for more than 35 diseases thought to be produced by immunopathology. Large amounts of immune globulin, such as 400 to 2000 mg/kg are proposed over a period of two to five days. The safety of this treatment, which may be introduced without any special structure, is a very interesting quality of the intravenous immune globulin therapy. However, comparative efficacy against reference therapy, surveillance for long-term positive and adverse effects and cost-effectiveness should be carried out.
authors.affiliation: Service de Médecine J, Centre Hospitalier Régional et Universitaire de Nancy, Hôpitaux de Brabois, Vandoeuvre-lès-Nancy.
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: P
authors.initials: P
authors.lastname: Kaminsky
authors.forename: M
authors.initials: M
authors.lastname: Duc
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D016756:Immunoglobulins, Intravenous
vernacular_title: Les immunoglobulines intraveineuses à fortes doses dans l'arsenal thérapeutique des maladies auto-immunes et des maladies de système.