title: Astasia-abasia revealing a primary Sjögren's syndrome.
abstract: A 63-year-old woman presented with mild arthralgias and inability to stand and walk without other significant neuropsychiatric abnormality. Neurological explorations showed intrathecal oligoclonal immunoglobulin production in CSF and numerous bright foci at brain MRI. A primary Sjögren's syndrome was concomitantly evidenced and was thought to be the cause of the astasia-abasia symptom by multiple brain involvement. Patient's condition gradually improved with hydroxychloroquine and corticosteroid therapy. Central nervous system involvement by primary Sjögren's syndrome is discussed.
authors.affiliation: Service de Rhumatologie, Hôpital Timone, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Lafforgue
authors.forename: E
authors.initials: E
authors.lastname: Toussirot
authors.forename: F
authors.initials: F
authors.lastname: Billé
authors.forename: P C
authors.initials: PC
authors.lastname: Acquaviva
mesh_terms: D001921:Brain / Q000473:pathology; D003291:Conversion Disorder / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D043025:Oligoclonal Bands; D011239:Prednisolone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D043025:Oligoclonal Bands; D006886:Hydroxychloroquine; D011239:Prednisolone