[The effect of new biologically active substances on effector T-lymphocytes in vitro].
Levamisole has been demonstrated to stimulate the activity of T effectors in patients with rheumatic arthritis directly and indirectly via production of the factors influencing effector functions. The organosilicon compound minval was beneficial both in patients and donors. Its activity was mediated by the production of factors in donors, whereas in patients it showed direct and indirect actions, being higher than that of levamisole. The bioflavonoid derived from the Rosa L. root was shown to exert no action on T-effector function.
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D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001782:Blood Donors; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D017646:Organosilicon Compounds; D010936:Plant Extracts / Q000494:pharmacology; D012828:Silicones / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D000276:Adjuvants, Immunologic; D005419:Flavonoids; D017646:Organosilicon Compounds; D010936:Plant Extracts; D012828:Silicones; D007978:Levamisole; C033818:1-(chloromethyl)silatrane
Vliianie novykh biologicheski aktivnykh veshchestv na éffektornye T-limfotsity in vitro.