Interstitial deletion of the long arm of chromosome 11 determined by fluorescence in situ hybridization.
An interstitial deletion, del(11)(q14q22), found in a female infant was examined by fluorescence in situ hybridization with cosmid DNA markers mapped on the long arm of chromosome 11. Three cosmids mapped on 11q14.1-11q22.1 region were not hybridized to the del(11) chromosome, while all the other DNA markers mapped on 11cen-11q14.1 and 11q23.1-11qter region gave hybridization signals on the del(11) chromosome. Cytogenetic analysis after R-banding confirmed an apparent deletion of 11q14-q22, but containing a small R-negative band, a part of 11q22.3 and/or 11q14.1, in the middle part of del(11) chromosome. The karyotype thus was determined to be 46,XX,del(11)(q14.1q22.3).
Hori
T
T
Division of Genetics, National Institute of Radiological Sciences, Chiba, Japan.
Masuno
M
M
Wakazono
A
A
Takahashi
E
E
Katakura
R
R
Orii
T
T
D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003360:Cosmids; D005260:Female; D005453:Fluorescence; D005819:Genetic Markers; D006801:Humans; D017403:In Situ Hybridization; D007223:Infant; D007621:Karyotyping
D005819:Genetic Markers