Bone marrow microenvironment of patients with systemic lupus erythematosus.
In an attempt to clarify the hematologic abnormality in systemic lupus erythematosus (SLE), we studied the bone marrow microenvironment of 8 women with this disease. The number of fibroblast colonies was similar to that of healthy control individuals. Culture supernatants of monocytes obtained from the patients with SLE showed a diminished production of the hemopoietic growth factor required to stimulate bone marrow fibroblasts. As the activity of the humoral factor released from SLE monocytes was diminished, such a reduction may play a role in the pathogenesis of the hematologic abnormality seen in SLE.
Otsuka
T
T
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nagasawa
K
K
Harada
M
M
Niho
Y
Y
D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology*; D001855:Bone Marrow Diseases / Q000209:etiology; D003114:Colony-Forming Units Assay; D017077:Culture Media, Conditioned; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D016298:Hematopoietic Cell Growth Factors / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009000:Monocytes / Q000378:metabolism / Q000473:pathology
D017077:Culture Media, Conditioned; D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors