title: Experimentally induced laminar necrosis, status verrucosus, focal cortical dysplasia reminiscent of microgyria, and porencephaly in the rat.
abstract: Different types of cortical malformation were produced, following focal cortical freezing, electrocoagulation, focal cortical aspiration or gentle brushing of uncovered meninges, in newborn or 1- to 3-day-old rats. Malformations included laminar necrosis of the cerebral cortex, status verrucosus, focal cortical dysplasia reminiscent of microgyria, and porencephaly. Similar procedures from postnatal day 4 onwards, at a time when a reactive astrogliosis is possible, produced cavitating infarcts and tissue scars. Cytoarchitectonic studies revealed an abnormal distribution of different types of pyramidal and non-pyramidal neurons in these malformations. These indicated three subtypes of focal cortical dysplasia, which probably depend on different pathogenic mechanisms. Autoradiographic studies with [3H] methylthymidine showed normal positioning of late-generated neuroblasts in the cerebral cortex, thus suggesting preserved migration. The present experimentally induced cortical malformations are useful models of similar cortical abnormalities in humans.
authors.affiliation: Unidad Neuropatología, Hospital Príncipes de España, Universidad de Barcelona, Hospitalet de Llobregat, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Ferrer
authors.forename: S
authors.initials: S
authors.lastname: Alcántara
authors.forename: I
authors.initials: I
authors.lastname: Catalá
authors.forename: M J
authors.initials: MJ
authors.lastname: Zújar
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D002540:Cerebral Cortex / Q000002:abnormalities / Q000473:pathology*; D004195:Disease Models, Animal; D005615:Freezing; D008578:Meninges / Q000473:pathology*; D009336:Necrosis; D009474:Neurons / Q000473:pathology*; D010320:Parvalbumins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
chemical_list: D015415:Biomarkers; D010320:Parvalbumins; D014316:Tritium; D013936:Thymidine