Synthesis and characterization of human neutrophil elastase inhibitors derived from aromatic esters of phenylalkanoic acids.
Kirschenheuter
G P
GP
Cortech, Inc., Denver, CO 80221.
Oleksyszyn
J
J
Spruce
L W
LW
Wieczorek
M
M
Kloppel
T M
TM
Simon
S R
SR
Cheronis
J C
JC
D010450:Endopeptidases / Q000378:metabolism; D005109:Extracellular Matrix / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D019272:Leukocyte Elastase; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D010654:Phenylbutyrates / Q000138:chemical synthesis / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology; D013329:Structure-Activity Relationship
D010654:Phenylbutyrates; D011480:Protease Inhibitors; D010450:Endopeptidases; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase