The nucleotide sequence of human aminoacylase-1.
The nucleotide sequence of a cDNA coding for human aminoacylase-1 (N-acylamino acid aminohydrolase, ACY-1, EC 3.5.1.14) subunit has been determined. The amino acid sequence of human ACY-1 subunit deduced from its cDNA nucleotide sequence showed a high degree of identity (87.7%) with the corresponding protein from porcine [1], although the former is one amino acid residue longer than the latter. Of 12 histidine and 3 cysteine residues, conserved between the proteins from two species, some are anticipated to form the active site of ACY-1 as either catalytic residues or ligands for an essential Zn2+ atom.
Mitta
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Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Otsu, Japan.
Kato
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Tsunasawa
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D000581:Amidohydrolases / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013552:Swine
D004247:DNA; D000581:Amidohydrolases; C019672:aminoacylase I