Platelet-derived growth factor and dexamethasone combined with a collagen matrix induce regeneration of the periodontium in monkeys.
Platelet-derived growth factor (PDGF) and the glucocorticoid dexamethasone combined with a collagen carrier matrix (CM) induced regeneration of the periodontium in monkeys. Regeneration was stringently defined as: (1) new cementum, (2) new supra-crestal bone extending coronally from the residual alveolar interdental septum and (3) functionally-oriented periodontal ligament fibers attaching new cementum to new bone. A single application of PDGF/dexamethasone/CM or CM was placed in debrided lesions of experimental periodontitis displaying 3-5 mm of attachment loss associated with horizontal and angular bony defects. Regeneration, judged histologically by these criteria and quantified by computer assisted histomorphometry after 4 weeks, was present only in PDGF/dexamethasone/CM treated lesions and not in those treated with CM or debridement alone. PDGF/dexamethasone/CM induced 5-fold more new cementum and ligament, and 7-fold more supra-crestal bone than control treatments. The presence of substantial amounts of regenerated periodontium including increased height of the alveolar bone; fill of vertically resorbed interdental alveolar septa in PDGF/dexamethasone/CM treated lesions suggests that this combination may provide a new therapeutic agent for the regeneration of lesions of periodontitis associated with horizontal as well as angular bony defects.
Rutherford
R B
RB
University of Connecticut School of Dental Medicine, Farmington 06030.
Ryan
M E
ME
Kennedy
J E
JE
Tucker
M M
MM
Charette
M F
MF
D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D003094:Collagen; D003739:Dental Cementum / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use*; D004848:Epithelium / Q000473:pathology; D016557:Guided Tissue Regeneration, Periodontal; D008252:Macaca fascicularis; D008297:Male; D010513:Periodontal Ligament / Q000473:pathology; D010518:Periodontitis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010519:Periodontium / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D019736:Prostheses and Implants; D013524:Surgical Flaps
D010982:Platelet-Derived Growth Factor; D003907:Dexamethasone; D003094:Collagen