[The effect of pyrazole on the conformational state of cell membrane phospholipids].
A change of conformation of phospholipids in the presence of pyrazole was studied by the method of 1H-NMR spectroscopy with the use of hydrophilic paramagnetic probes Pr3+. It was shown that the ratio of transformation of the polar groups of the bilayer surface of sonicated phosphatidyl-choline increased in the presence of pyrazole as compared to the experimental values of the induced pseudocontact shifts of the phosphorylcholine groups. It was established that the earlier discovered complexes of pyrazole-phospholipids in the inert solution exhibited in the water phase.
Nasibullin
R S
RS
Sultanova
V S
VS
Zagitov
G N
GN
Zeleev
M Kh
MKh
D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D008051:Lipid Bilayers; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010743:Phospholipids / Q000737:chemistry*; D011720:Pyrazoles / Q000494:pharmacology*
D008051:Lipid Bilayers; D010743:Phospholipids; D011720:Pyrazoles; C031280:pyrazole
Vliianie pirazola na konformatsionnoe sostoianie fosfolipidov kletochnykh membran.