title: [Behavior of pachytene chromosomes in male mice heterozygotic for various translocations (Rb(8,17), T(16,17)43H)].
abstract: The electron microscopic analysis of synaptonemal complexes of the Robertsonian translocation heterozygotes (Rb/T) and heterozygotes of the reciprocal translocation (Rb(8, 17)/T(16, 17) 43H revealed three types of translocation configurations (TC). The observed TC were subdivided into three types according to the manner of synapsis: 1) full synapsis of homologues forming trivalent with interstitial centromere in 15%; 2) the centromeric asynapsis (8 and 17-16 chromosomes forming trivalent with the extension region of asynapsis and breakpoint of the reciprocal translocation on chromosome 17 in 70%; 3) centromeric asynapsis (only single chromosome 17-16 of trivalent, when the break point of reciprocal translocation and the absence of centromeric asynapsis of another chromosome 8 formed trivalent in 15%). The frequency of association between trivalents and the XY bivalents is 20% and close proximity is 15% for heterozygotes Rb/T. Which are fertile, while in the sterile heterozygotes Rb(8, 17)/T(16, 17) 43H it is 45% for association and 15% close proximity (total 60%). These data show the significant differences in the contact of translocation configurations with the XY bivalents of fertile heterozygotes, in comparison with the sterile. Thus, it is shown that the chromosome pairing of fertile and sterile mice is clearly distinguished.
authors.forename: L D
authors.initials: LD
authors.lastname: Safronova
authors.forename: V N
authors.initials: VN
authors.lastname: Orlov
mesh_terms: D000818:Animals; D002875:Chromosomes; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D008540:Meiosis / Q000235:genetics*; D051379:Mice; D013091:Spermatogenesis / Q000235:genetics; D014178:Translocation, Genetic
vernacular_title: Povedenie khromosom v pakhitene u samtsov mysheĭ, geterozigotnykh po razlichnym translokatsiiam (Rb(8,17),T(16,17)43H).