title: Increased serum level of interleukin-5 in a patient with episodic angioedema and eosinophilia syndrome.
abstract: A case of episodic angioedema and eosinophilia syndrome is reported. An 18-year-old male suffered from monthly episodes of angioedema, pruritic papules, weight gain, and fever for twelve years. During the episodes, peripheral eosinophils and serum levels of interleukin (IL)-5, an eosinophil proliferating cytokine were elevated. Extensive evaluations disclosed neither visceral involvement nor evidence of parasitic infections, collagen diseases, or neoplastic disorders. Corticosteroid treatment brought about a dramatic clinical improvement concomitant with decrement of eosinophils and serum IL-5 was observed. These observations suggest that IL-5 may be a causative factor for this pathological state.
authors.affiliation: Department of Internal Medicine (Section 4), Sapporo Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Kogawa
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Sakamaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kohgo
authors.forename: K
authors.initials: K
authors.lastname: Hamabe
authors.forename: N
authors.initials: N
authors.lastname: Ishiyama
authors.forename: H
authors.initials: H
authors.lastname: Enokihara
authors.forename: Y
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000293:Adolescent; D000799:Angioedema / Q000276:immunology*; D004802:Eosinophilia / Q000276:immunology*; D006801:Humans; D015848:Interleukin-5 / Q000097:blood*; D008297:Male; D012008:Recurrence; D013577:Syndrome
chemical_list: D015848:Interleukin-5