Endocervical glandular atypia and adenocarcinoma: a correlation of cytology and histology.
Of the 34,384 cervical smears sampled by cervical scraping and Cytobrush, reactive glandular atypia was found in 1.7%, low-grade glandular atypia in 0.08%, and high-grade glandular atypia/adenocarcinoma in 0.05%. Cells of reactive glandular atypia and low-grade atypia could be distinguished from those of high-grade atypia/adenocarcinoma by the architecture of the cellular aggregates, nuclear morphology, and nuclear-cytoplasmic ratios. Further histologic studies found that most reactive and low-grade atypias were associated with condyloma, squamous dysplasia, carcinoma in situ, and cervicitis. Eighty-two percent of women with cellular evidence of high-grade atypia/adenocarcinoma were confirmed to have in situ or invasive adenocarcinoma of the cervix. Although Cytobrush samples seem to improve the detection of early-stage glandular neoplasms, many minor atypias unrelated to cervical carcinogenesis are also detected.
Nasu
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Department of Pathology, University of California, Los Angeles School of Medicine.
Meurer
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W
Fu
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D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology*; D002278:Carcinoma in Situ / Q000150:complications / Q000473:pathology; D002449:Cell Aggregation; D002466:Cell Nucleolus / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology*; D003218:Condylomata Acuminata / Q000150:complications / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology*; D002575:Uterine Cervicitis / Q000150:complications / Q000473:pathology; D014626:Vaginal Smears