title: A detailed genetic map for the X chromosome of the malaria vector, Anopheles gambiae.
abstract: Anopheles gambiae, the primary vector of human malaria in Africa, is responsible for approximately a million deaths per year, mostly of children. Despite its significance in disease transmission, this mosquito has not been studied extensively by genetic or molecular techniques. To facilitate studies on this vector, a genetic map has been developed that covers the X chromosome at an average resolution of 2 centimorgans. This map has been integrated with the chromosome banding pattern and used to localize a recessive, sex-linked mutation (white eye) to within 1 centimorgan of flanking markers.
authors.affiliation: Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.
authors.forename: L
authors.initials: L
authors.lastname: Zheng
authors.forename: F H
authors.initials: FH
authors.lastname: Collins
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: F C
authors.initials: FC
authors.lastname: Kafatos
mesh_terms: D000483:Alleles; D000818:Animals; D000852:Anopheles / Q000235:genetics*; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D017344:Genes, Insect; D005808:Genes, Recessive; D005819:Genetic Markers; D007303:Insect Vectors / Q000235:genetics*; D008288:Malaria / Q000635:transmission; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D011995:Recombination, Genetic; D014960:X Chromosome
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers