Intracavernous application of SIN-I in rabbit and man: functional and toxicological results.
The mode of action of the active metabolite SIN-I of the vasodilator prodrug molsidomine was studied in vitro and in vivo in corpus cavernosum of rabbit and man. SIN-I produces a dose-dependent relaxation of isolated human cavernous smooth muscle strips. In the rabbit, the intracavernous application of SIN-I increased the intracavernous pressure to a full erection (approximately 100 cm H2O). This response was highly reproductible. SIN-I was also injected intracavernously 6 times in five rabbits over 2 weeks; no inflammatory or fibrotic reactions were found on histology. SIN-I may be a reliable drug for the treatment of impotence without side-effects.
Meyer
M F
MF
Urologische Klinik, Medizinischen Hochschule, Hannover, Germany.
Taher
A
A
Krah
H
H
Staubesand
J
J
Becker
A J
AJ
Kircher
M
M
Mayer
B
B
Jonas
U
U
Forssmann
W G
WG
Stief
C G
CG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008981:Molsidomine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000187:drug effects* / Q000473:pathology; D011817:Rabbits; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D014665:Vasodilator Agents; C002385:linsidomine; D008981:Molsidomine