[New central analgesic-acting triaminopyridines].
New Triaminopyridines with a Central Analgesic Activity 2-Amino-3-((prop-1-en-3-yl)oxycarbonylamino)-6-(4-fluorobenzyla mino) pyridine hydrochloride (D-19050) is a centrally and peripherally acting analgesic with rapid onset, long duration of action and a good therapeutic range. D-19050 can be obtained in a 5-step-synthesis starting from 2,6-dichloropyridine.
Emig
P
P
Forschung der Asta Medica AG, Frankfurt/Main.
Nickel
B
B
Weischer
C H
CH
Szelenyi
I
I
Engel
J
J
D000631:Aminopyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D004357:Drug Synergism; D004597:Electroshock; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D051381:Rats
D000631:Aminopyridines; D000700:Analgesics; D002219:Carbamates; C082620:D 19050; D009270:Naloxone; D000431:Ethanol; D006591:Hexobarbital
Neue zentralanalgetisch wirksame Triaminopyridine.