Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats.
The effects of tetrahydroberberine (THB) on ischemic and reperfused myocardium were studied in comparison with verapamil (Ver). In anesthetized rats, THB and its analogues, l-THP and l-SPD, reduced the infarct size after 4 h of left anterior descending coronary artery (LAD) ligation. In Langendorff hearts, in common with Ver, THB 1 and 10 mumol.L-1 markedly decreased the incidences of ventricular tachycardia (VT) and ventricular fibrillation (VF) in the reperfusion period. The malondialdehyde content and xanthine oxidase activity were also decreased in global ischemic-reperfused hearts pretreated with THB (P < 0.01, or P < 0.05). It suggested that THB could protect the myocardium from ischemic and reperfusion injury.
Zhou
J
J
Department of Pharmacology, Nanjing Medical College, China.
Xuan
B
B
Li
D X
DX
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D001600:Berberine Alkaloids / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D001600:Berberine Alkaloids; D001599:Berberine; C010513:stepholidine; C014215:tetrahydropalmatine; D008315:Malondialdehyde; D014700:Verapamil; D014969:Xanthine Oxidase; C004645:canadine