title: MR imaging of muscle and tender points in fibromyalgia.
abstract: Fibromyalgia is a syndrome manifested by chronic, diffuse musculoskeletal aching and soreness, palpable muscle tender points, and other symptoms. Standardized clinical diagnostic criteria have recently been developed. Skeletal muscle has been postulated as the end organ in this disease. Biochemical, histologic, electromyographic, and conventional radiographic studies have demonstrated no definitive abnormality. This study sought to establish whether magnetic resonance (MR) imaging could demonstrate any abnormality in these patients. Eighteen patients were entered in the study, 14 of whom were able to complete their examinations. T1-weighted, T2-weighted, gradient-echo, and STIR (short-tau inversion-recovery) sequences were performed in all patients, with selected patients examined with T1-weighted, gadopentetate dimeglumine-enhanced sequences. The trapezius and suboccipital regions were imaged in patients who, clinically, had active fibromyalgia. No abnormalities could be detected. The authors conclude that the conventional MR imaging used in this study was unable to depict any primary skeletal muscle abnormality in fibromyalgia.
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, University Hospital, University of Western Ontario, London, Canada.
authors.forename: M M
authors.initials: MM
authors.lastname: Kravis
authors.forename: P L
authors.initials: PL
authors.lastname: Munk
authors.forename: G A
authors.initials: GA
authors.lastname: McCain
authors.forename: A D
authors.initials: AD
authors.lastname: Vellet
authors.forename: M F
authors.initials: MF
authors.lastname: Levin
mesh_terms: D000328:Adult; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis*; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine; D009132:Muscles / Q000473:pathology*; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA