title: Estimation of reference intervals from a SENIEUR protocol compatible aged population for immunogerontological studies.
abstract: Because many laboratory values change with age, the study of healthy aging as well as diagnosis of disease in geriatric patients requires specific age-corrected reference intervals. We have established such reference intervals for a healthy population aged 65-74 years by selection of a sample group applying the clinical criteria of the SENIEUR protocol and we have compared them with those of a young control group (20-33 years) fulfilling the same criteria. Significant or minor elevations were seen, e.g. for plasma concentrations of fasting glucose, urea, total and LDL-cholesterol, triglycerides, gamma-glutamyl-transferase, alkaline phosphatase, erythrocyte sedimentation rate and serum neopterin levels. These reference intervals can be used for selecting a SENIEUR compatible population aged between 65 and 74 years. Additionally, plasma lipid parameters (cholesterol, triglycerides) are proposed to be included in the SENIEUR protocol.
authors.affiliation: Institute for General and Experimental Pathology, University of Innsbruck, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Stulnig
authors.forename: A
authors.initials: A
authors.lastname: Mair
authors.forename: E
authors.initials: E
authors.lastname: Jarosch
authors.forename: M
authors.initials: M
authors.lastname: Schober
authors.forename: D
authors.initials: D
authors.lastname: Schönitzer
authors.forename: G
authors.initials: G
authors.lastname: Wick
authors.forename: L A
authors.initials: LA
authors.lastname: Huber
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood* / Q000276:immunology; D002985:Clinical Protocols; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D012016:Reference Values
chemical_list: D008055:Lipids