Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells.
Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-architecture only with other grafted cells and not with the host's cells.
Rosenfeld
J V
JV
Walter and Eliza Hall Institute of Medical Research, Parkville, Vic., Australia.
Richards
L J
LJ
Bartlett
P F
PF
D000818:Animals; D002465:Cell Movement; D002531:Cerebellum / Q000196:embryology / Q000502:physiology*; D005260:Female; D016332:Fetal Tissue Transplantation; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D011689:Purkinje Cells / Q000502:physiology* / Q000637:transplantation*; D015398:Signal Transduction