[A giant esophageal ulcer in a hemophiliac with HIV infection].
A 21-year-old man with hemophilia B and human immunodeficiency virus (HIV) infection was admitted with hematemesis and melena. After admission, esophagogram and endoscopy showed a single giant ulcer with ovoid shape and slightly irregular margins in the middle esophagus. Biopsy specimens of the esophageal ulcer showed non-specific granulation and etiology was unknown. Therapeutic trails of famotidine, sodium alginate, acyclovir, and amphotericin B did not result in favorable response. With a combination therapy of dexamethasone and sucralfate, the swallowing pain was rapidly disappeared with gradual improvement of the ulcer. To our knowledge, this is the first report of a giant esophageal ulcer in a HIV infected patient in Japan.
Muraoka
K
K
Department of Pediatrics, Saga Prefectural Hospital.
Hara
T
T
Kajiwara
T
T
Simoda
Y
Y
Miyamoto
Y
Y
Miyazaki
S
S
D000284:Administration, Oral; D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004935:Esophageal Diseases / Q000188:drug therapy / Q000209:etiology*; D015658:HIV Infections / Q000150:complications*; D002836:Hemophilia B / Q000209:etiology*; D006801:Humans; D008297:Male; D013392:Sucralfate / Q000008:administration & dosage; D014456:Ulcer / Q000188:drug therapy / Q000209:etiology
D013392:Sucralfate; D003907:Dexamethasone