Avian Eimeria: effects of gamma irradiation on development of cross-species immunity in foreign and natural host birds.
Repeated inoculation (immunization) of white leghorn chickens with oocysts of the turkey coccidium, Eimeria adenoeides, resulted in significantly improved weight gain and feed-conversion ratios (feed efficiency) after E. tenella challenge. However, the development E. tenella in the immunized chickens did not differ markedly from that in unimmunized chickens, and intestinal lesions remained severe (greater than 3.0). Apparently improved weight gain and feed efficiency can be maintained in the presence of extensive parasite development. The ability to elicit cross-protective immunity was abrogated when the E. adenoeides oocysts were exposed to 15 kRad of gamma irradiation before inoculation into the chickens. Sporozoites existing from irradiated oocysts of E. acervulina also failed to immunize the chickens against challenge with E. tenella but protected chickens almost completely against homologous challenge with E. acervulina. The results indicate that cross-species immunity is not elicited by all developmentally arrested sporozoites and that the ability to produce cross-species immunity can be destroyed by gamma irradiation of the immunizing species.
Augustine
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PC
U.S. Department of Agriculture, Agricultural Research Center, Livestock and Poultry Science Institute, Beltsville, Maryland 20705.
Danforth
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HD
Jenkins
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MC
D000818:Animals; D002645:Chickens / Q000276:immunology* / Q000469:parasitology; D003048:Coccidiosis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D004435:Eating; D004539:Eimeria / Q000276:immunology* / Q000528:radiation effects; D005720:Gamma Rays; D007109:Immunity / Q000528:radiation effects; D008854:Microscopy, Electron / Q000662:veterinary; D011201:Poultry Diseases / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D013045:Species Specificity; D014611:Vaccination / Q000662:veterinary*; D015430:Weight Gain