title: Experience with doxorubicin-bound polyisohexylcyanoacrylate nanoparticles on murine alveolar echinococcosis of the liver.
abstract: The parasiticidal properties of doxorubicin against the metacestode of Echinococcus multilocularis were investigated after binding of that drug to polyisohexylcyanoacrylate nanoparticles, a colloidal biodegradable drug carrier. A reduction of the hepatic parasite development and a reduced viability of the metacestode were observed in mice injected with 5 mg kg-1 body weight-1, but 7.5 mg kg-1 body weight-1 did not appear more efficient. Free doxorubicin or unbound nanoparticles had no antiparasitic activity.
authors.affiliation: Laboratoire de Parasitologie, Faculté de Médecine, Créteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Liance
authors.forename: F
authors.initials: F
authors.lastname: Nemati
authors.forename: C
authors.initials: C
authors.lastname: Bories
authors.forename: P
authors.initials: P
authors.lastname: Couvreur
mesh_terms: D000818:Animals; D003102:Colloids; D003487:Cyanoacrylates; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D004337:Drug Carriers; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D005260:Female; D051379:Mice; D008806:Mice, Inbred AKR
chemical_list: D003102:Colloids; D003487:Cyanoacrylates; D004337:Drug Carriers; C042633:poly(hexyl-2-cyanoacrylate); D004317:Doxorubicin