title: [Prognostic value of the tissue expression of human chorionic gonadotropin (beta-HCG) in infiltrating transitional carcinoma of the bladder].
abstract: Study of the ectopic secretion of Human Chorionic Gonadotrophin (beta-HCG) in the tumoral tissue of 62 patients diagnosed with infiltrant transitional carcinoma of the bladder. The inmunohistochemical tests showed specific stains in 15/62 patients. Bi-varied analysis showed that vesical tumours with beta-HCG ectopic expression present associated nodular disease with a significantly higher prevalence (p = 0.02). Survival of patients with beta-HCG+ tumours was overall lower that of patients with beta-HCG-tumours, but this difference did not reach statistical significance. Multivariate analysis of survival showed no prognostic value for the tissue expression of beta-HCG, when it is considered as an isolated variable. Complete local response was seen in 5/6 beta-HCG+ patients treated with pre-operative chemo and radiotherapy and in 1/4 patients treated with pre-operative radiotherapy. Tissular expression of beta-HCG is a poor prognostic factor due to its relationship with another 2 variables of larger predictive capability: the presence of metastatic nodular disease and the infiltration of venous and/or lymphatic structures of the vesical wall.
authors.affiliation: Departamento de Urología, Facultad de Medicina, Universidad de Navarra, Pamplona.
authors.forename: F
authors.initials: F
authors.lastname: De Castro
authors.forename: C
authors.initials: C
authors.lastname: Robledo
authors.forename: L
authors.initials: L
authors.lastname: Agüera
authors.forename: D
authors.initials: D
authors.lastname: Rosell
authors.forename: J E
authors.initials: JE
authors.lastname: Robles
authors.forename: J J
authors.initials: JJ
authors.lastname: Zudaire
authors.forename: J M
authors.initials: JM
authors.lastname: Berián
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000401:mortality* / Q000628:therapy; D006063:Chorionic Gonadotropin / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin
vernacular_title: Valor pronóstico de la expresión tisular de gonadotrofina coriónica humana (beta-HCG) en el carcinoma transicional infiltrante de vejiga.