Interpretive criteria and quality control parameters for determining bacterial susceptibility to fosfomycin tromethamine.
Studies with fosfomycin tromethamine disks containing 200 micrograms of fosfomycin and 50 micrograms of glucose-6-phosphate confirmed the following zone diameter criteria for the NCCLS method: < or = 12 mm for resistant (MIC > or = 256 micrograms/ml), 13-15 mm for intermediate (MIC 128 micrograms/ml) and > or = 16 mm for susceptible (MIC < or = 64 micrograms/ml). Additional studies defined acceptable MIC and zone diameter ranges for the following quality control strains: Escherichia coli ATCC 25922, MIC 0.5 to 4.0 micrograms/ml, zone diameter 23 to 29 mm; Staphylococcus aureus ATCC 25923, zone diameter 26 to 32 mm; Pseudomonas aeruginosa ATCC 27813, MIC 2.0 to 8.0 micrograms/ml; and Enterococcus faecalis, ATCC 29212, MIC 16 to 64 micrograms/ml.
Barry
A L
AL
Clinical Microbiology Institute, Tualatin, Oregon 97062.
Pfaller
M A
MA
Fuchs
P C
PC
Tenover
F C
FC
Reller
L B
LB
Allen
S D
SD
Hardy
D J
DJ
Gerlach
E H
EH
D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D005578:Fosfomycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000592:standards*; D011786:Quality Control; D012044:Regression Analysis; D014325:Tromethamine / Q000031:analogs & derivatives* / Q000494:pharmacology
D014325:Tromethamine; D005578:Fosfomycin