title: Reproducibility of antipyrine half-lives in elderly subjects.
abstract: Antipyrine half-life determined on three to five separate occasions over a period ranging from 3 weeks to 1 year was highly reproducible in each of 20 elderly subjects (12 women and 8 men; mean age, 83 years). The mean within-subject coefficient of variation for antipyrine half-life was 9.6%, whereas the between-subject coefficient of variation was 33.3%. These findings indicate high reproducibility of individual rates of drug metabolism in medically stable elderly subjects.
authors.affiliation: Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033.
authors.forename: E S
authors.initials: ES
authors.lastname: Vesell
authors.forename: T M
authors.initials: TM
authors.lastname: DeAngelo
authors.forename: I R
authors.initials: IR
authors.lastname: Katz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000983:Antipyrine / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D015203:Reproducibility of Results
chemical_list: D000983:Antipyrine