title: Quantitative monitoring of capsular contraction around smooth and textured implants.
abstract: The purpose of this study was to assess the efficacy of textured silicone implants in reducing the incidence of capsular contracture. Each of 10 female New Zealand, albino rabbits received 2 saline-filled implants, 1 on either side of the lateral chest wall. The surface of 1 implant was smooth silicone, whereas the other implant's surface was textured silicone. Magnetic resonance imaging (MRI) scans of the implants were performed at 0, 9, 17, 26, 34, and 40 weeks after implantation. Data from the MRI scans were used to calculate the effective surface area of implants at each analysis interval. This technique provided a noninvasive method of monitoring implant contraction as a function of time. Eight rabbits completed the study. Four of 8 smooth implants developed contractures, whereas none of the textured implants developed contracture. For the 4 smooth implants that developed contractures, MRI scans calculated 72 +/- 12% contraction at 17 weeks, but the Baker palpation test detected only mild firmness. From 17 to 40 weeks, the mean percentage of contraction for these implants changed minimally, but their mean Baker score increased from mild to severe (II to IV). Quantitative data from MRI scans were much more predictive of final implant contraction than palpation (Baker test), applanation tonometry, or indentation tonometry. The latter two tests only detected the final stages of severe implant contraction.
authors.affiliation: Plastic Surgery Research, University of Virginia Health Sciences Center, Charlottesville 22908.
authors.forename: R M
authors.initials: RM
authors.lastname: Brohim
authors.forename: P A
authors.initials: PA
authors.lastname: Foresman
authors.forename: G M
authors.initials: GM
authors.lastname: Grant
authors.forename: M B
authors.initials: MB
authors.lastname: Merickel
authors.forename: G T
authors.initials: GT
authors.lastname: Rodeheaver
mesh_terms: D000818:Animals; D004867:Equipment Design; D005260:Female; D015994:Incidence; D008279:Magnetic Resonance Imaging; D019736:Prostheses and Implants / Q000009:adverse effects*; D011817:Rabbits; D012828:Silicones; D013499:Surface Properties; D013997:Time Factors
chemical_list: D012828:Silicones