Anomalous bronchospasm following inhalation of (+) isoprenaline by asthmatics.
Sympathomimetics (beta-adrenergic agonists) presently used in asthma therapy comprise racemic mixtures of bronchodilator and non-bronchodilator enantiomers. In a randomized, double-blind placebo-controlled study, asthmatic subjects inhaled a nebulized solution of the non-bronchodilator (+) enantiomer of isoprenaline. Substantial decreased forced expiratory volume (FEV1) was detected in 2 patients and of the remaining 8, a single subject had increased reactivity to histamine 7 h after inhalation of (+) isoprenaline. These effects of (+) isoprenaline may contribute to anomalous effects of (+/-) isoprenaline in asthma.
Hansel
T T
TT
Swiss Institute of Allergy and Asthma Research (SIAF), Basel.
Schwarz
F
F
Villiger
B
B
Naef
R
R
Richardson
B P
BP
Morley
J
J
D000280:Administration, Inhalation; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000139:chemically induced*; D004311:Double-Blind Method; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage / Q000009:adverse effects*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
D007545:Isoproterenol