title: Functional-morphological effect of the synthetic atrial natriuretic factor (ANF 101-126) on the zona glomerulosa cells of adrenal cortex.
abstract: The effects of atrial natriuretic factor (ANF) on the adrenal steroidogenesis were examined in the zona glomerulosa of rats in vivo. ANF administration provoked a significant decrease in the width of zona glomerulosa (P < 0.01) and a significant enlargement of nuclei of zona glomerulosa cells (P < 0.01). Ultrastructurally conspicuous change was observed in mitochondria of the cells of the zona glomerulosa treated with ANF, representing elongated mitochondria with "parallel arrays" of tubules with pipe-like structure. In vitro autoradiography 125I-labelled ANF binding displayed a significant decrease of a specific receptor site in the zona glomerulosa treated with ANF. A significant lowering in plasma levels of aldosterone was observed in ANF-treated rats. These findings could be interpreted as an inhibitory effect of ANF on adrenal steroidogenesis of the glomerular zone by action through a specific ANF-receptor.
authors.affiliation: Department of Pathology, Nagasaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: K
authors.initials: K
authors.lastname: Shigematsu
authors.forename: A
authors.initials: A
authors.lastname: Nakatani
authors.forename: J
authors.initials: J
authors.lastname: Irie
authors.forename: T
authors.initials: T
authors.lastname: Kamio
authors.forename: H
authors.initials: H
authors.lastname: Tsuchiyama
mesh_terms: D000450:Aldosterone / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D008297:Male; D008854:Microscopy, Electron; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015384:Zona Glomerulosa / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D010446:Peptide Fragments; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; C043970:atrial natriuretic factor 26, rat; D003345:Corticosterone