title: A pilot clinical trial of the angiotensin-converting enzyme inhibitor ceranapril in Alzheimer disease.
abstract: This pilot clinical trial was a 15-week, double-blind, controlled, three-way crossover study evaluating cognitive effects of ceranapril in subjects with dementia of the Alzheimer type (age range 50-75 years). Computerized (CNTB) and noncomputerized cognitive test batteries revealed no significant results (p > 0.05). On further analysis of the data, however, a study of longer duration and/or higher dosages may be warranted.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey.
authors.forename: A
authors.initials: A
authors.lastname: Sudilovsky
authors.forename: N R
authors.initials: NR
authors.lastname: Cutler
authors.forename: J J
authors.initials: JJ
authors.lastname: Sramek
authors.forename: T
authors.initials: T
authors.lastname: Wardle
authors.forename: A E
authors.initials: AE
authors.lastname: Veroff
authors.forename: W
authors.initials: W
authors.lastname: Mickelson
authors.forename: J
authors.initials: J
authors.lastname: Markowitz
authors.forename: S
authors.initials: S
authors.lastname: Repetti
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009943:Organophosphorus Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D010865:Pilot Projects; D011392:Proline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D009943:Organophosphorus Compounds; D011392:Proline; C054518:ceronapril