title: Minimization of hemolysis in centrifugal blood pumps: influence of different geometries.
abstract: Centrifugal blood pumps are of substantial importance for intraoperative extracorporeal circulation and for temporary cardiac assist. Their development and improvement raises many specific questions, especially on mechanical blood properties, flow distribution, and the resulting biocompatibility. In this comprehensive study the influence of various pump geometries on blood trauma was investigated. For this purpose analytical calculations, hydrodynamic performance, numerical simulation, in vitro hemolysis tests and in vivo experiments were used. The gap between rotor and housing was found to be crucial showing a distinct minimum of hemolysis at a gap of 1.5 mm (in vitro increase of plasma free hemoglobin per 100 ml plasma an hour: delta fHb/hour = 2.4 +/- 0.83 mg%/h at 1.5 mm versus 12 +/- 2.2 mg%/h at 2.5 mm; p < 0.05). Housing diameter and shape of the vanes were of less importance for blood traumatization (d = 60 mm: delta fHb/hour = 6.36 +/- 1.8 mg%/h; d = 70 mm: fHb = 7.1 +/- 1.9 mg%/h; straight radial vanes: 5.2 +/- 1.8 mg%/h; straight inclined vanes: 6.8 +/- 1.2 mg%/h; flexed vanes: 6.1 +/- 2.0 mg%/h). Three animal experiments confirmed the optimization of geometry, with a mean fHb of 2.5 to 3.2 mg% in steady state. Hydrodynamic efficiency revealed to be a necessary, but not a sufficient and sensitive criterion for hemolysis minimization (e.g. changes of eta < 10% for changes of fHb > 500%). Numerical simulation gives an improved insight in flow distribution, but can not yet be applied for quantification of blood trauma.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: 2nd Department of Surgery, University of Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Schima
authors.forename: M R
authors.initials: MR
authors.lastname: Müller
authors.forename: D
authors.initials: D
authors.lastname: Papantonis
authors.forename: C
authors.initials: C
authors.lastname: Schlusche
authors.forename: L
authors.initials: L
authors.lastname: Huber
authors.forename: C
authors.initials: C
authors.lastname: Schmidt
authors.forename: W
authors.initials: W
authors.lastname: Trubel
authors.forename: H
authors.initials: H
authors.lastname: Thoma
authors.forename: U
authors.initials: U
authors.lastname: Losert
authors.forename: E
authors.initials: E
authors.lastname: Wolner
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D005112:Extracorporeal Circulation / Q000295:instrumentation*; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006353:Heart-Assist Devices; D006461:Hemolysis; D006801:Humans; D012212:Rheology; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials