Hereditary spastic paraparesis. Clinical and genetic data from a large Dutch family.
A large Dutch family is presented with pure hereditary spastic paraparesis. Pedigree analysis indicates autosomal dominant inheritance with complete penetrance and possibly anticipation in successive generations. These observations may have implications for genetic studies. Linkage studies in this family have excluded more than 40% of the autosomal genome.
Bruyn
R P
RP
Department of Neurology, Oudenrijn Hospital, Utrecht, The Netherlands.
van Deutekom
J
J
Frants
R R
RR
Padberg
G W
GW
D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D001405:Reflex, Babinski; D012026:Reflex, Stretch; D012737:Sex Factors; D015419:Spastic Paraplegia, Hereditary / Q000175:diagnosis* / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000175:diagnosis; D014057:Tomography, X-Ray Computed