Modified high-performance liquid chromatographic method for analysis of drotaverine in human plasma.
An HPLC method is described for the determination of drotaverine in plasma; papaverine is used as the internal standard. The lower limit of quantitation is 50 ng ml-1 with an inter-assay precision (RSD) of below 4%. The method has been validated and successfully used to assay clinical trial samples in healthy volunteers.
Lalla
J K
JK
Principal K.M. Kundnani College of Pharmacy, Bombay, India.
Shah
M U
MU
Jain
M B
MB
Sharma
A H
AH
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010208:Papaverine / Q000031:analogs & derivatives* / Q000097:blood; D010276:Parasympatholytics / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet
D010276:Parasympatholytics; C005317:drotaverin; D010208:Papaverine