Progressive nemaline rod myopathy in a woman coinfected with HIV-1 and HTLV-2.
Nemaline-rod myopathy was recently reported in eight young males infected with human immune deficiency virus type 1 (HIV-1). A 41-year-old woman had a 2-year history of progressive proximal-muscle weakness. Muscle biopsy demonstrated the presence of nemaline rods, predominantly in type 1 fibers. She was coinfected with HIV-1 and HTLV-2, as evidenced by positive polymerase chain reaction and serology. There was no lymphopenia or CD4 lymphopenia, despite an abnormal T-cell subset ratio, high CD8 count, skin anergy, and depressed in vitro response to mitogens. This case raises the possibility that dual infection may play a role in the pathogenesis of the rare nemaline-rod myopathies of HIV-infected patients.
Maytal
J
J
Division of Pediatric Neurology, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
Horowitz
S
S
Lipper
S
S
Poiesz
B
B
Wang
C Y
CY
Siegal
F P
FP
D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D015497:HIV-1; D015491:HTLV-II Infections / Q000150:complications* / Q000473:pathology; D006801:Humans; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology*; D009210:Myofibrils / Q000473:pathology