title: Antithyroid antibodies underlying thyroid abnormalities and miscarriage or pregnancy induced hypertension.
abstract: OBJECTIVE
  To assess whether asymptomatic abnormalities, including thyroid auto-antibodies, were associated with an abnormal miscarriage rate or a poor obstetric outcome.
  
  
  METHODS
  Prospective study of thyroid auto-antibodies and thyroid function in an unselected obstetric population.
  
  
  METHODS
  Saint-Pierrie Hospital, Brussels, Belgium.
  
  
  METHODS
  Seven hundred and thirty consecutive pregnant women attending the antenatal clinic.
  
  
  METHODS
  Miscarriage and pregnancy induced hypertension.
  
  
  RESULTS
  Elevated antithyroperoxidase (TPO-Ab) and antithyroglobulin (TG-Ab) antibody titres are associated with an increased miscarriage rate. Also, asymptomatic thyroid abnormalities, mainly abnormal echo-structure but not antithyroid antibodies, are associated with pregnancy induced hypertension.
  
  
  CONCLUSIONS
  The presence of thyroid auto-antibodies during pregnancy constitutes a marker of increased risk of miscarriage and poor obstetric prognosis.
authors.affiliation: Department of Gynaecology and Obstetrics, Université Libre de Bruxelles, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Lejeune
authors.forename: J P
authors.initials: JP
authors.lastname: Grun
authors.forename: P
authors.initials: P
authors.lastname: de Nayer
authors.forename: G
authors.initials: G
authors.lastname: Servais
authors.forename: D
authors.initials: D
authors.lastname: Glinoer
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology* / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000276:immunology; D008875:Middle Aged; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology* / Q000276:immunology; D011446:Prospective Studies; D012307:Risk Factors; D013959:Thyroid Diseases / Q000276:immunology; D013961:Thyroid Gland / Q000002:abnormalities / Q000276:immunology*
chemical_list: D001323:Autoantibodies