Can soluble antigens induce CD8+ cytotoxic T-cell responses? A paradox revisited.
Cytotoxic T lymphocyte (CTL) induction usually follows processing of antigens via endogenous pathways before presentation on the cell surface in association with MHC class I molecules. Soluble antigens do not, in general, induce specific CTL responses. Here, Syamal Raychaudhuri and John Morrow suggest that a novel adjuvant formulation can elicit CTL responses to soluble antigens and discuss the implications for vaccine development.
Raychaudhuri
S
S
IDEC Pharmaceuticals Corporation, La Jolla, CA 92037.
Morrow
W J
WJ
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D016827:CD8 Antigens; D015395:Histocompatibility Antigens Class I; D006801:Humans; D066298:In Vitro Techniques; D010586:Phagocytes / Q000276:immunology; D011506:Proteins / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000276:Adjuvants, Immunologic; D016827:CD8 Antigens; D015395:Histocompatibility Antigens Class I; D011506:Proteins