title: Ultrasonic tissue characterization of experimental venous intimal hyperplasia.
abstract: Ultrasonic tissue characterization (UTC) employing slope and Y-intercept parameters from the normalized power spectrum of backscattered echoes was employed in vivo to study compositional changes in the walls of pig jugular veins in which thrombi were experimentally induced. Light microscopy revealed these changes to be intimal hyperplasia with an early predominance of smooth muscle cells and a later mixture of smooth muscle cells and collagen deposits. UTC distinguished intimal hyperplasia from previously reported data from luminal thrombosis UTC. Furthermore, UTC was able to discriminate between early (predominantly smooth muscle cells) and older (smooth muscle cells plus collagen deposits) intimal hyperplasia. The study suggests that intimal hyperplasia in the experimental model used may be organized thrombus and that UTC may be able to follow both the development of wall changes as well as luminal changes occurring in venous thrombosis.
authors.affiliation: Department of Surgery, Medical College of Pennsylvania, Philadelphia 19129.
authors.forename: R E
authors.initials: RE
authors.lastname: Parsons
authors.forename: B
authors.initials: B
authors.lastname: Sigel
authors.forename: E J
authors.initials: EJ
authors.lastname: Feleppa
authors.forename: R M
authors.initials: RM
authors.lastname: Golub
authors.forename: J
authors.initials: J
authors.lastname: Justin
authors.forename: V K
authors.initials: VK
authors.lastname: Swami
authors.forename: M
authors.initials: M
authors.lastname: Rorke
authors.forename: A
authors.initials: A
authors.lastname: Kalisz
authors.forename: C D
authors.initials: CD
authors.lastname: Long
authors.forename: A
authors.initials: A
authors.lastname: Can
mesh_terms: D000818:Animals; D003094:Collagen; D004195:Disease Models, Animal; D006965:Hyperplasia; D007601:Jugular Veins / Q000000981:diagnostic imaging* / Q000473:pathology*; D013552:Swine; D013924:Thrombophlebitis / Q000000981:diagnostic imaging / Q000473:pathology; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D003094:Collagen