Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in rats.
Graded injections of argipressin (Arg, 150, 300, and 600 ng/1.5 microliters CSF, 2 min) into the medial amygdaloid body in anesthetized rats produced a dose-related increase in the mean arterial pressure and heart rate (Maximal delta MAP = 2.9 +/- 1.5 kPa, Maximal delta HR = 67 +/- 38 bpm), which lasting > 40 min at 600 ng dosage. Naloxone (15 micrograms/15 microliters CSF) injected into the lateral ventricle blocked the cardiovascular responses to Arg. These results suggest that Arg exerts a central action on the cardiovascular system via the opioid in the lateral ventricle.
Jiang
N C
NC
Department of Physiology, Guiyang Medical College, China.
Gao
L
L
Chen
C
C
Pan
Y
Y
Liu
D C
DC
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D001127:Arginine Vasopressin; D009270:Naloxone