title: The detection of ventricular dysfunction and carditis in children with Kawasaki disease using equilibrium multigated blood pooling ventriculography and 99Tcm-HMPAO-labelled WBC heart scans.
abstract: Thirty-seven children (11 girls, 26 boys; aged 2.8 +/- 2.2 years) with Kawasaki disease (KD) were included in the study. The biventricular functions were evaluated by equilibrium multigated blood pooling ventriculography (EMBPV) and the severity of carditis was decided by Tc-hexamethylpropyleneamine oxime (HMPAO) labelled white blood cell (WBC) heart scans (Tc-WBC). The results showed that 43% (16/37) of the KD cases with the severe carditis by Tc-WBC had the worst left ventricular ejection fraction (LVEF) (55.4 +/- 15.6%) and right ventricular ejection fraction (RVEF) (43.7 +/- 12.2%) by EMBPV; 24% (9/37) of the cases with the mild carditis had the best LVEF (63.5% +/- 8.2%) and RVEF (53.7% +/- 11.2%); the remaining 32% (12/37) had moderately severe carditis and biventricular function (LVEF: 58.2 +/- 17.2% and RVEF: 46.9 +/- 19.5%). Because Tc-WBC cannot only detect the severity of carditis but also predict impairment of ventricular function accurately, the choice of Tc-WBC should be preferable for KD-a common inflammatory cardiovascular disease in children.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Republic of China.
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: K S
authors.initials: KS
authors.lastname: Hsieh
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: S H
authors.initials: SH
authors.lastname: Yeh
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D015637:Gated Blood-Pool Imaging; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000000981:diagnostic imaging / Q000209:etiology; D007962:Leukocytes; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D016276:Ventricular Function / Q000502:physiology*
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime