title: Lipoprotein abnormalities in hypertriglyceridaemic patients on long-term haemodialysis.
abstract: OBJECTIVE
  To analyse by ultracentrifugation in a zonal rotor the plasma lipoproteins in hypertriglyceridaemic patients on long-term haemodialysis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Tertiary referred care centre.
  
  
  METHODS
  Ten consecutive hypertriglyceridaemic patients on haemodialysis and 12 consecutive healthy controls.
  
  
  METHODS
  Plasma lipid and lipoprotein cholesterol concentrations, lipoprotein physical properties and compositions, apolipoprotein concentrations.
  
  
  RESULTS
  Hypertriglyceridaemia in patients undergoing haemodialysis is characterized by an increased amount of small and slow floating very-low density lipoproteins (VLDL), higher concentrations of intermediate density lipoproteins (IDL) and small and dense low-density lipoprotein (LDL) particles; reduced levels of high-density lipoproteins (HDL), in particular of HDL2. The lipoprotein composition of such patients indicates reduced cholesterol ester and increased triglyceride content. Compared to controls, they have lower levels of plasma apolipoprotein A-I and A-II and higher B, C-II, C-III and E values.
  
  
  CONCLUSIONS
  The lipoprotein abnormalities observed in hypertriglyceridaemic patients undergoing haemodialysis have recently been associated with an increased incidence of vascular complications and may in part explain the high incidence of vascular disease reported in these subjects.
authors.affiliation: Department of Internal Medicine, University of Padova, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Zambon
authors.forename: A
authors.initials: A
authors.lastname: Zambon
authors.forename: N
authors.initials: N
authors.lastname: Stabellini
authors.forename: G
authors.initials: G
authors.lastname: Tarroni
authors.forename: P
authors.initials: P
authors.lastname: Gilli
authors.forename: G
authors.initials: G
authors.lastname: Crepaldi
authors.forename: E
authors.initials: E
authors.lastname: Manzato
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D014461:Ultracentrifugation
chemical_list: D008074:Lipoproteins