title: The association of Helicobacter pylori with differentiated-type early gastric cancer.
abstract: BACKGROUND
  Recent studies have indicated that infection with Helicobacter pylori is closely associated with increased risk for gastric cancer. Previous studies, however, usually have been made on cases of advanced gastric cancer.
  
  
  METHODS
  The Congo red-methylene blue test was performed on 19 healthy subjects, 24 patients with early gastric cancer of differentiated type, and 17 patients with early cancer of undifferentiated type. H. pylori infection was examined by culture of biopsy specimens obtained from noncancerous antral mucosa.
  
  
  RESULTS
  H. pylori was detected in 19 (79%) of 24 patients with differentiated-type early gastric cancer, but in only 5 (29%) of 17 patients with undifferentiated-type early gastric cancer; this difference was statistically significant. It also was detected significantly more frequently in patients with differentiated cancers than in healthy subjects.
  
  
  CONCLUSIONS
  H. pylori infection was closely associated with differentiated-type gastric cancers, but not with undifferentiated types.
authors.affiliation: Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tatsuta
authors.forename: H
authors.initials: H
authors.lastname: Iishi
authors.forename: S
authors.initials: S
authors.lastname: Okuda
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Yokota
mesh_terms: D000367:Age Factors; D001706:Biopsy; D005753:Gastric Mucosa / Q000382:microbiology; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D008875:Middle Aged; D011230:Precancerous Conditions / Q000382:microbiology; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology