How tautological are interspecies correlations of carcinogenic potencies?
Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.
Freedman
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Statistics Department, University of California, Berkeley 94720.
Gold
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Slone
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D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology*; D051381:Rats; D012107:Research Design; D013045:Species Specificity; D013223:Statistics as Topic