Possible antifertility agents belonging to substituted indoles.
Of the 21 compounds evaluated for antiimplantation and abortifacient activities, compounds (A1, A2, A4 and B1) and compounds (C1, C2, D1 and D3) were found to exhibit 40% and 30% antiimplantation activity, respectively, in female rats when given orally on days 1-5 postcoitum. The remaining 13 compounds were found to be inactive. All of the 21 compounds were also tested for the abortifacient activity, but all were found to be inactive.
Hiremath
S P
SP
Department of Chemistry, Gulbarga University, India.
Bajji
A C
AC
Rao
S H
SH
D000019:Abortifacient Agents / Q000737:chemistry; D000818:Animals; D003281:Contraceptives, Postcoital / Q000737:chemistry; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013723:Teratogens / Q000633:toxicity
D000019:Abortifacient Agents; D003281:Contraceptives, Postcoital; D007211:Indoles; D013723:Teratogens