title: [Severe bone malformations in fetal valproic acid disease].
abstract: The dysmorphogenic and teratogenic effects of valproic acid, when administered to pregnant women, have been noted in several reports. We report the case of a 3-month-old infant with multiple congenital anomalies, including severe skeletal malformations, congenital heart defect and facial dysmorphism, whose mother was treated with valproic acid (1000 mg/day) throughout the pregnancy. This is the second published case reporting major skeletal malformations and supports the possible teratogenic effects of valproic acid.
authors.affiliation: Sección de Neuropediatría, Hospital Ramón y Cajal, Madrid.
authors.forename: G
authors.initials: G
authors.lastname: Lorenzo Sanz
authors.forename: C
authors.initials: C
authors.lastname: Serna Saugar
authors.forename: A
authors.initials: A
authors.lastname: Quintana Castilla
authors.forename: C
authors.initials: C
authors.lastname: Lozano Giménez
authors.forename: J M
authors.initials: JM
authors.lastname: Aparicio Meix
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D001842:Bone and Bones / Q000002:abnormalities*; D005145:Face / Q000002:abnormalities*; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D014635:Valproic Acid
vernacular_title: Malformaciones esqueléticas severas en la fetopatía por ácido valproico.