title: Acute effects of shock waves on tumors assessed by magnetic resonance imaging. Possible role of blood flow reduction.
abstract: OBJECTIVE
  The effects of shock waves on experimental tumors in vivo by gadolinium(+)-DTPA-enhanced magnetic resonance imaging (MRI) are assessed.
  
  
  METHODS
  Two amelanotic hamster melanomas were implanted in the dorsal skin of 19 hamsters. In experiment 1 (n = 7), MRI of untreated tumors was performed before, and 5 and 15 minutes after intravenous injection of Gd(+)-DTPA. In experiment 2 (n = 12), 200 shock waves were applied on one of the implanted tumors. Magnetic resonance imaging was performed 15 minutes after treatment before, and 5 and 15 minutes after injection of Gd(+)-DTPA.
  
  
  RESULTS
  In experiment 1, signal intensities (SI) of untreated tumors increased after injection of Gd(+)-DTPA. In experiment 2, enhancement was significantly delayed in shock-wave-treated tumors as compared with controls. Histology of the treated tumors revealed vascular damage.
  
  
  CONCLUSIONS
  Differences in enhancement between shock-wave-treated and control tumors after injection of Gd(+)-DTPA are interpreted as the consequence of reduced and delayed accumulation of Gd(+)-DTPA in treated tumors due to shock wave induced vascular damage and reduced tumor perfusion.
authors.affiliation: Institute of Surgical Research, Ludwig Maximilians University Munich, Klinikum Grosshadern, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Gamarra
authors.forename: M
authors.initials: M
authors.lastname: Naegele
authors.forename: W
authors.initials: W
authors.lastname: Lumper
authors.forename: A E
authors.initials: AE
authors.lastname: Goetz
mesh_terms: D000818:Animals; D003287:Contrast Media; D006224:Cricetinae; D005682:Gadolinium; D019786:Gadolinium DTPA; D008096:Lithotripsy; D008279:Magnetic Resonance Imaging; D008297:Male; D008546:Melanoma, Experimental / Q000098:blood supply* / Q000175:diagnosis; D008647:Mesocricetus; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA