title: Hyperglycemia in the acute phase of stroke is not caused by stress.
abstract: OBJECTIVE
  Hyperglycemia in the acute phase of stroke is associated with poor outcome. Whether hyperglycemia in nondiabetic stroke patients is caused by stress is controversial.
  
  
  METHODS
  We studied glucose levels and glycosylated hemoglobin in 91 consecutive patients with acute stroke admitted within 24 hours after onset of symptoms. In 27 unselected patients we also measured catecholamines on days 1 and 3 after onset.
  
  
  RESULTS
  Hyperglycemia was found in 39 (43%) of the patients, 55% of whom either had diabetes mellitus or latent diabetes; the others had idiopathic hyperglycemia. Norepinephrine levels were associated with the severity of the stroke (P = .005) and with hypertension (P = .03) but not with glucose levels, irrespective of whether or not the patients had diabetes.
  
  
  CONCLUSIONS
  We conclude that hyperglycemia in the acute phase of stroke cannot be explained by increased stress.
authors.affiliation: Department of Neurology, University Hospital Rotterdam, Dijkzigt, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: van Kooten
authors.forename: N
authors.initials: N
authors.lastname: Hoogerbrugge
authors.forename: P
authors.initials: P
authors.lastname: Naarding
authors.forename: P J
authors.initials: PJ
authors.lastname: Koudstaal
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002561:Cerebrovascular Disorders / Q000097:blood / Q000150:complications*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D013312:Stress, Physiological / Q000150:complications*
chemical_list: D001786:Blood Glucose; D004837:Epinephrine; D006442:Glycated Hemoglobin; D009638:Norepinephrine