Induction of lipid-protein mismatch by xenobiotics with general membrane targets.
Many membrane-active xenobiotics, such as organic solvents or general anesthetics, are without specific target sites. A common, but as yet ill-defined physical mechanism of action is usually assumed. Displacement of 'boundary' lipid activators from functional membrane proteins by the induction of lipid/protein mismatch is now established as a candidate common physical mechanism. Multiple binding site kinetics demonstrate that xenobiotics can be strongly inhibitory at realistic membrane concentrations of below 4 mol%. A general equation for inhibition is derived.
Sandermann
H
H
Institut für Biochemische Pflanzenpathologie, GSF München, Neuherberg, Germany.
D001665:Binding Sites; D007700:Kinetics; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D015262:Xenobiotics / Q000494:pharmacology*
D008563:Membrane Lipids; D008565:Membrane Proteins; D015262:Xenobiotics