title: Physics and engineering of transcatheter cardiac tissue ablation.
abstract: Ablation of arrhythmogenic cardiac tissues has emerged as one of the most important advances in cardiac electrophysiology. With the introduction of transcatheter ablation, the treatment of ventricular tachycardia, Wolff-Parkinson-White syndrome and other cardiac arrhythmias has progressed from an expensive and painful surgical therapy accompanied by a long recovery period to the less expensive, less traumatic transcatheter approach. The feasibility of cardiac ablation, along with the increasing number of physicians using the technique, requires understanding of the anatomic and electrophysiologic bases of transcatheter ablation as well as the different technologies, their limitations and complications. This report provides an overview of the physical, scientific and technical aspects of cardiac ablation performed with the methods currently available and a summary of the limitations of each method and expected future technologic developments in this growing field. Emphasis is placed on radiofrequency and direct current energies, the primary methods now used. Methods such as cryoablation and laser, and microwave and chemical ablation are discussed with less detail because the method of delivering energy for these ablative procedures has not been fully developed.
authors.affiliation: Electrophysiology Laboratory, University of Wisconsin-Milwaukee Clinical Campus, Sinai Samaritan Medical Center 53201.
authors.forename: B
authors.initials: B
authors.lastname: Avitall
authors.forename: M
authors.initials: M
authors.lastname: Khan
authors.forename: D
authors.initials: D
authors.lastname: Krum
authors.forename: J
authors.initials: J
authors.lastname: Hare
authors.forename: C
authors.initials: C
authors.lastname: Lessila
authors.forename: A
authors.initials: A
authors.lastname: Dhala
authors.forename: S
authors.initials: S
authors.lastname: Deshpande
authors.forename: M
authors.initials: M
authors.lastname: Jazayeri
authors.forename: J
authors.initials: J
authors.lastname: Sra
authors.forename: M
authors.initials: M
authors.lastname: Akhtar
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000601:surgery; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods / Q000639:trends; D004738:Engineering; D004867:Equipment Design; D006801:Humans; D055585:Physical Phenomena; D010825:Physics