Studies of topical carbonic anhydrase inhibitors: ocular hypotensive effect of thiadiazole derivatives.
A series of thiadiazole derivatives were topically applied in gels or suspensions to rabbits to determine their ocular hypotensive effect. As a result, the compounds with higher corneal permeabilities showed stronger effect in lowering IOP. In addition, gels also caused stronger effect than suspensions. Different concentrations of gel preparations produced diverse ocular hypotensive effects. A linear relationship between the integrated IOP response and logarithm concentration of inhibitor was found. It is proposed that the ocular hypotensive effect was attributed to the level of inhibitor in ciliary body.
Chiang
C H
CH
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Lee
A R
AR
Lin
C H
CH
D000287:Administration, Topical; D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D003315:Cornea / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D015814:Ocular Hypotension / Q000188:drug therapy* / Q000503:physiopathology; D011817:Rabbits; D013830:Thiadiazoles / Q000494:pharmacology*
D002257:Carbonic Anhydrase Inhibitors; D013830:Thiadiazoles