Nasal administration of IgA to individuals with hypogammaglobulinemia.
Many immunodeficient patients constantly carry non-typable Hemophilus influenzae (NTHI) in the nasopharynx, despite seemingly adequate antibiotic therapy. We have studied the effect of nasal administration of IgA on nasopharyngeal colonization in 5 patients with hypogammaglobulinemia, with a productive cough, especially in the mornings, who were constant carriers of NTHI in the nasopharynx, and had IgA, 1 ml 6 times/day, given nasally for 14 days. Nasopharyngeal cultures were obtained on days 0, 7, 14 and 28. Two of the patients became culture-negative during the treatment, and the cough was alleviated in all patients.
Lindberg
K
K
Department of Otorhinolaryngology, Huddinge University Hospital, Sweden.
Samuelson
A
A
Rynnel-Dagöö
B
B
Smith
E
E
Hammarström
L
L
D000281:Administration, Intranasal; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D002353:Carrier State / Q000382:microbiology / Q000628:therapy*; D015169:Colony Count, Microbial; D003371:Cough / Q000150:complications; D005260:Female; D006192:Haemophilus Infections / Q000382:microbiology / Q000628:therapy*; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D007070:Immunoglobulin A / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000382:microbiology*
D007070:Immunoglobulin A