title: Isolation of camelliaside C from "tea seed cake" and inhibitory effects of its derivatives on arachidonate 5-lipoxygenase.
abstract: A new flavonol glycoside, camelliaside C, was isolated from "tea seed cake" prepared from the defatted seeds of Camellia sinensis O. Kuntze. The structure was determined as kaempferol 3-O-beta-D-galactopyranosyl-(1-->2)-beta-D-glucopyranoside by spectroscopic methods (FAB-MS, UV, IR, 1H- and 13C-NMR) and the enzymatic transformation of camelliaside C to astragalin. Camelliaside C showed an inhibitory effect on the arachidonate 5-lipoxygenase of RBL-1 cells (IC50:1.4 x 10(-4)M) as did camelliaside A and B isolated from the same product.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sekine
authors.forename: Y
authors.initials: Y
authors.lastname: Arai
authors.forename: F
authors.initials: F
authors.lastname: Ikegami
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: S
authors.initials: S
authors.lastname: Shindo
authors.forename: T
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: S
authors.initials: S
authors.lastname: Okonogi
authors.forename: I
authors.initials: I
authors.lastname: Murakoshi
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D005419:Flavonoids; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044949:Kaempferols; D016859:Lipoxygenase Inhibitors; D008969:Molecular Sequence Data; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D013662:Tea / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D005419:Flavonoids; D006027:Glycosides; D044949:Kaempferols; D016859:Lipoxygenase Inhibitors; D013662:Tea; C083110:camelliaside C; D011794:Quercetin