title: Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract.
abstract: We have extended our earlier observations on pain relief produced by intravesical instillation of capsaicin (10 microM in saline) in patients with hypersensitive disorders of the lower urinary tract. Patients in group A (n = 15) received intravesical capsaicin on days 0, 14 and 28: on each occasion the drug produced a warm or burning sensation, reduction in bladder capacity and a delayed, transient improvement or disappearance of symptoms. Patients in group B (n = 5) received intravesical capsaicin (10 microM at cystometry) 3 times on day 0. The initial sensation of warmth was experienced on each occasion, indicating that no significant desensitisation has been produced by the first instillation. Clinical improvement similar to that found in group A was observed. Three patients (group C) received warm saline (42 degrees C) at cystometry. This produced a pricking sensation, no change at cystometry and no subjective clinical improvement. Apart from the initial sensation of warmth, no patient in group A or B experienced side effects, either local or systemic. These findings confirm that intravesical instillation of capsaicin has a beneficial effect on patients with hypersensitive bladder disorders. Counter-irritation rather than desensitisation of primary afferents could be a possible mechanism of action. Further studies are needed to establish whether the intravesical administration of capsaicin or capsaicin-like agents represents a new form of treatment for relief of bladder pain.
authors.affiliation: Department of Pharmacology, A. Menarini Pharmaceuticals, Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Barbanti
authors.forename: C A
authors.initials: CA
authors.lastname: Maggi
authors.forename: P
authors.initials: P
authors.lastname: Beneforti
authors.forename: P
authors.initials: P
authors.lastname: Baroldi
authors.forename: D
authors.initials: D
authors.lastname: Turini
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D002211:Capsaicin / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D012678:Sensation Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001745:Urinary Bladder Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D014554:Urination / Q000187:drug effects
chemical_list: D002211:Capsaicin