title: Accurate and precise blood glucose measurement in the hypoglycaemic range.
abstract: The aim of the study was to evaluate the performance of an electrochemical blood glucose sensor, the satellite G, in the low-normal and hypoglycaemic range. Eighty-five venous blood samples with glucose concentrations below 4.0 mmol I-1 from six patients with Type 1 diabetes undergoing induced hypoglycaemia were measured in duplicate on the sensor and a reference method, the Yellow Springs whole blood glucose analyser. The sensor values correlated well with the reference method (r = 0.9, p < 0.001) with a mean absolute percentage bias of 10.7%. The 95% confidence limits of agreement between methods were +0.7 and -0.6 mmol I-1 with a mean difference of 0.004 mmol I-1. More than 80% of the sensor measurements were within 20%, and 60% were within 10% of the reference method. Measured over all samples, the sensor had a coefficient of variation of 7.2% for paired measurements. The coefficients of variation of 20 measurements on each of two samples with glucose concentrations of 1.3 and 2.6 mmol I-1 were 9.1% and 5.8%, respectively. We conclude that the satellite G measures blood glucose accurately and precisely in the low range.
authors.affiliation: Diabetes Unit, Hope Hospital, Salford, UK.
authors.forename: K L
authors.initials: KL
authors.lastname: Tieszen
authors.forename: A W
authors.initials: AW
authors.lastname: Patrick
authors.forename: E
authors.initials: E
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Williams
authors.forename: T L
authors.initials: TL
authors.lastname: Dornan
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000175:diagnosis*; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose