Alternative splicing of the mRNA encoding the alpha subunits of the G(o) GTP-binding protein during brain development and in neuronal cell lines.
The RNA encoding the alpha subunit of the G(o) GTP-binding protein is alternatively spliced in some tissues to produce mRNAs encoding two distinct forms of the protein which differ at the carboxyl terminus. This alternative splicing process is observed at all stages during development of the rat brain and heart and in some but not all neuronal cell lines. These effects are discussed both in terms of the regulation of the alternative splicing event and the functional role(s) of the two forms of the protein which it produces.
Horn
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Department of Biochemistry, University College and Middlesex School of Medicine, London, UK.
Latchman
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DS
D016475:3T3 Cells; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology; D001921:Brain / Q000196:embryology* / Q000254:growth & development / Q000502:physiology*; D002460:Cell Line; D004622:Embryo, Mammalian / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D019204:GTP-Binding Proteins / Q000235:genetics*; D051379:Mice; D009474:Neurons / Q000502:physiology*; D012326:RNA Splicing; D051381:Rats
D019204:GTP-Binding Proteins