[Radiation-induced cerebrovasculopathy: a case report and review of the literature].
We reported a case of a patient who suffered from a cerebrovasculopathy after irradiation therapy for astrocytoma located at the left temporal lobe. An eleven year-old boy who presented himself with headache and vomiting as his chief complaints received partial removal of a tumor. Histological diagnosis of the tumor was astrocytoma (grade II). His preoperative cerebral angiograms showed mass sign solely, without stenosis or occlusion of the cerebral vessel. Postoperatively, he was treated with irradiation therapy involving the whole brain with a total of 30 Gy, and gamma knife therapy. Six months after irradiation, he started suffering from frequent cerebral ischemic attacks, but there was no regrowth of the tumor visible on CT scans. Cerebral angiograms were made again, and revealed multifocal stenoses in the bilateral internal carotid arteries, middle cerebral arteries, and the anterior cerebral artery. His symptoms did not improve after conservative treatment with steroids, calcium antagonist, or low molecular weight dextran. Although he received a superficial temporal artery-middle cerebral artery (STA-MCA) anastomoses bilaterally, multiple cerebral infarctions appeared. Although irradiation therapy is acceptable in patients with brain tumor, a cerebrovasculopathy after irradiation should be considered as one of the most important complications, and the risk incurred by irradiation therapy should lead to more careful consideration and caution when treating intracranial brain tumors, especially in children. From our experience, the usefulness of bypass surgery for radiation-induced cerebrovasculopathy is still controversial.
Ikeyama
Y
Y
Department of Neurosurgery, Ube Industries Central Hospital.
Abiko
S
S
Kurokawa
Y
Y
Okamura
T
T
Watanabe
K
K
Inoue
S
S
Fujii
Y
Y
D001254:Astrocytoma / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000532:radiotherapy; D002548:Cerebral Revascularization; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000601:surgery; D002648:Child; D006801:Humans; D008297:Male; D011832:Radiation Injuries / Q000209:etiology* / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects*; D013702:Temporal Lobe