title: Acute and subchronic oral toxicity of technical quinalphos in rats.
abstract: The organophosphate insecticide quinalphos is extensively used in agriculture. Information on the mammalian toxicity of quinalphos is limited. The acute po LD50 of technical quinalphos was 19.95 mg/kg in males and 13.78 mg/kg in female rats. Administration of 0.75, 1.50 or 3.0 mg/kg/d technical quinalphos for 90 d po to rats produced poisoning and death. Male rats were more susceptible to quinalphos than female rats in the subchronic toxicity studies based on mortality, enzyme profiles and cholinesterase inhibition.
authors.affiliation: Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
authors.forename: R B
authors.initials: RB
authors.lastname: Raizada
authors.forename: M K
authors.initials: MK
authors.lastname: Srivastava
authors.forename: R P
authors.initials: RP
authors.lastname: Singh
authors.forename: R A
authors.initials: RA
authors.lastname: Kaushal
authors.forename: K P
authors.initials: KP
authors.lastname: Gupta
authors.forename: T S
authors.initials: TS
authors.lastname: Dikshith
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; C009145:quinalphos