title: Lys- and Leu-aminopeptidase activity after acute toluene exposure in the rat brain.
abstract: Changes in Lys- and Leu-aminopeptidase activities in several brain regions of the rat, after acute toluene administration, are described in this research. Aminopeptidase activity has been suggested as a candidate regulator of the degradation of several neuroactive peptides. Lys-aminopeptidase activity was significantly decreased in the thalamus, amygdala, and medulla oblongata. Leu-aminopeptidase activity was significantly decreased in the thalamus and cerebellum. It is suggested that these aminopeptidase activities could play a part in the mechanism of toluene neurotoxicity.
authors.affiliation: Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: De Gandarias
authors.forename: E
authors.initials: E
authors.lastname: Echevarria
authors.forename: J
authors.initials: J
authors.lastname: Irazusta
authors.forename: E
authors.initials: E
authors.lastname: Casis
authors.forename: L
authors.initials: L
authors.lastname: Casis
mesh_terms: D000626:Aminopeptidases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D007931:Leucyl Aminopeptidase / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014050:Toluene / Q000633:toxicity*
chemical_list: D014050:Toluene; D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; C056860:lysyl aminopeptidase