title: Proton MR and human cervical neoplasia: ex vivo spectroscopy allows distinction of invasive carcinoma of the cervix from carcinoma in situ and other preinvasive lesions.
abstract: The concept that high-resolution (8.5-T) hydrogen-1 magnetic resonance (MR) spectroscopy can be used as an adjunct to conventional histologic diagnosis of cervical neoplasia was investigated. Cervical biopsy specimens (n = 159) were examined with H-1 MR spectroscopy and the results compared with results of histopathologic analysis. A high-resolution lipid MR spectrum was observed in 39 of 40 invasive carcinomas, whereas the 119 preinvasive samples showed little or no lipid spectrum but were characterized by a strong unresolved resonance between 3.8 and 4.2 ppm. Peak ratios of the methylene/methyl and the unresolved/methylene resonances allowed accurate distinction between invasive and preinvasive epithelial malignancy (P < .0001). Since MR spectroscopic examination does not destroy the specimen, the specimens remained intact for further testing and histopathologic analysis. The authors conclude that H-1 MR spectroscopy can independently allow distinction between invasive and preinvasive lesions of the cervix and has the potential to assist in clinical management of cervical cancer.
authors.affiliation: Membrane NMR Unit, University of Sydney, New South Wales, Australia.
authors.forename: E J
authors.initials: EJ
authors.lastname: Delikatny
authors.forename: P
authors.initials: P
authors.lastname: Russell
authors.forename: J C
authors.initials: JC
authors.lastname: Hunter
authors.forename: R
authors.initials: R
authors.lastname: Hancock
authors.forename: K H
authors.initials: KH
authors.lastname: Atkinson
authors.forename: C
authors.initials: C
authors.lastname: van Haaften-Day
authors.forename: C E
authors.initials: CE
authors.lastname: Mountford
mesh_terms: D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology