Growth factors of the future.
Hematopoietic growth factors stimulate proliferation and enhance functional activity of hematopoietic cells. Erythropoietin, recombinant human (rh) granulocyte colony stimulating factor (CSF), rh granulocyte macrophage CSF and rh interferon have been proven to be a clinically useful therapy. Several other cytokines with other unique effects are being developed for possible clinical usage. The purpose of this manuscript is to review novel uses of current approved cytokines and potential application of experimental growth factors.
Nemunaitis
J
J
Directory of Hematopoiesis Program, Western Pennsylvania Cancer Institute, Pittsburgh 15224.
D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016207:Cytokines / Q000627:therapeutic use*; D005544:Forecasting; D006133:Growth Substances / Q000627:therapeutic use*; D006402:Hematologic Diseases / Q000188:drug therapy; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007378:Interleukins / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use
D016207:Cytokines; D006133:Growth Substances; D016298:Hematopoietic Cell Growth Factors; D007155:Immunologic Factors; D007378:Interleukins; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha