Role of vasoactive intestinal polypeptide (VIP), secretin and gastrin in the genesis of the late exocrine pancreatic hypersecretion, food intake dependent in conscious dogs.
Plasma levels of vasoactive intestinal polypeptide (VIP), secretin and gastrin were studied in four saphenous vein-catheterized dogs during the first 12 h after ingestion of a standard solid meal. Under these conditions we found significant postprandial increases in secretion only, which rose from a basal value of 219 +/- 27 pg/ml to 449 +/- 66 pg/ml 60 min postprandial (p < 0.001), and remained elevated until 4 h after food intake. However, no increase was seen from 8 to 12 h in any of the hormones studied, indicating that they are not directly involved in the enhancement of exocrine pancreatic secretion during this period.
Huertas
J R
JR
Department of Physiology, Institute of Nutrition and Food Technology, Faculty of Pharmacy, University of Granada, Spain.
Mañas
M
M
Ballesta
M C
MC
Mataix
F J
FJ
Martinez-Victoria
E
E
D000818:Animals; D004032:Diet; D004285:Dogs; D004435:Eating / Q000502:physiology*; D005260:Female; D005755:Gastrins / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D012633:Secretin / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D014660:Vasoactive Intestinal Peptide