[Infection and systemic lupus erythematosus: analysis of a series of 145 patients].
Systemic lupus erythematosus (SEL) is a chronic inflammatory disease, which often requires corticosteroid treatment, being infection a common cause of both morbidity and mortality. We report the infectious episodes from 145 SLE patients revisited through 1975-1991, with a 6.8 years mean follow-up period. The relationship between each episode and several variables, especially corticosteroid treatment a month before the infectious episode, was analyzed. Forty two infections were diagnosed in 32 patients (22.06%). A significant increase in the number of infections among SLE patients with daily corticosteroids treatment was observed with respect to that of SLE patients with alternate day treatment (p < 0.001). The administration corticosteroids in alternate day form, if possible, can decrease the infection incidence in SLE patients.
Formiga Pérez
F
F
Servicio de Medicina Interna, Hospital de Bellvitge-Princeps d'Espanya, Barcelona.
Moga Sampere
I
I
Canet González
R
R
Pac Ferraz
M
M
Mitjavila Villero
F
F
Fernández Nogués
F
F
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies
D000305:Adrenal Cortex Hormones
Infección y lupus eritematoso sistémico: análisis de una serie de 145 pacientes.