title: [Anti-centriole antibodies and high neuron-specific enolase activity in a patient with Raynaud phenomenon, cerebrovascular lesions, and ischemic finger necrosis--a functional relationship?].
abstract: In a 49-year-old patient with acute thrombangitis obliterans, several vascular risk factors and associated features of collagen vascular disease, we observed anti-centriole autoantibodies and a strongly elevated neuron-specific enolase (NSE). The latter could not be attributed to an underlying malignant or neuroendocrine disease. The recent identification of NSE as a centrosomal protein suggests a causal relationship between anti-centriole autoantibodies and elevated serum NSE levels.
authors.affiliation: Abteilung Rheumatologie, Medizinische Universitätsklinik Freiburg.
authors.forename: T
authors.initials: T
authors.lastname: Terreri
authors.forename: A
authors.initials: A
authors.lastname: Niederhoff
authors.forename: M
authors.initials: M
authors.lastname: Zabel
authors.forename: U
authors.initials: U
authors.lastname: Blum
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications*; D002502:Centrioles / Q000276:immunology*; D002561:Cerebrovascular Disorders / Q000150:complications*; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000150:complications; D008875:Middle Aged; D009336:Necrosis; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011928:Raynaud Disease / Q000150:complications*
chemical_list: D001323:Autoantibodies; D010751:Phosphopyruvate Hydratase
vernacular_title: Anti-Zentriolen-Antikörper und hohe neuronenspezifische Enolase-Aktivität bei einer Patientin mit Raynaud-Phänomen, zerebrovaskulären Läsionen und ischämischen Fingernekrosen--ein assoziierter Befund?