title: [Anthelmintic control of multiresistant nematodes in the gastrointestinal tract of imported goats].
abstract: Multiple resistant strains of Ostertagia and Trichostrongylus were detected in a flock of cashmere and angora goats imported from New Zealand. The ED50 values detected by in vitro EHA test were from 0.27 to 0.36 micrograms/ml (while the reference value of sensitivity is 0.10 microgram/ml TBZ). Multiple resistance to all the types of currently used anthelmintics was confirmed by in vivo FECRT, when the efficacy of recommended doses was lower than 90% (albendazole 74%, levamisole 86%, ivermectin 83%). Two control schemes were investigated. In the simultaneous application of anthelmintics in the double or triple of recommended doses (0.4 mg/kg ivermectin s.c., 30 mg/kg levamisole and 20 mg/kg albendazole p.o.) was effective. Examination of goats 7 and 8 months after treatment revealed the repeated presence of multiple resistant gastrointestinal nematodes. It is the first published case of intercontinental transfer of resistant strains of nematodes when importing small ruminants.
authors.affiliation: Helmintologický ústav SAV, Kosice.
authors.forename: J
authors.initials: J
authors.lastname: Corba
authors.forename: M
authors.initials: M
authors.lastname: Várady
authors.forename: J
authors.initials: J
authors.lastname: Praslicka
authors.forename: L
authors.initials: L
authors.lastname: Veselý
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D004351:Drug Resistance; D015511:Goat Diseases / Q000188:drug therapy* / Q000469:parasitology; D006041:Goats; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics
vernacular_title: Antihelmintické ovplyvnenie polyrezistentných nematódov gastrointestinálneho traktu u importovaných kôz.