[The effect of ethanol on the occurrence of peptides with antibacterial effects in the rat myocardium]].
The effect of 7% ethanol on the peptide content in the myocardium was studied during prolonged exposition. The protein-free extract from the myocardium of controls as well as experimental groups following 1-8 weeks ethanol administration contained peptides with antibacterial activity. Long-term ethanol administration resulted in changes in physico-chemical properties of peptides both compared with controls and also among the experimental groups mutually. The changes were manifested by differences in the elution profiles following gel chromatography and RF values after electrophoresis or by different amino acid composition. The results are compared with the influence of peptides on the growth of bacterial cultures S. aureus. Ethanol administration induced diminution of the diameter of the inhibitory zones. This effect was most marked in the group fed with ethanol for 3 and 8 weeks. (Fig. 5, Ref. 17.)
Adam
J
J
Katedra lekárskej chémie a biochémie LF UPJS, Kosice, Slovakia.
Surzin
J
J
Chavková
Z
Z
Grega
B
B
D000596:Amino Acids / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents; D002850:Chromatography, Gel; D000431:Ethanol / Q000494:pharmacology*; D006321:Heart / Q000382:microbiology*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000254:growth & development*; D014020:Tissue Extracts / Q000494:pharmacology
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D014020:Tissue Extracts; D000431:Ethanol
Vplyv etanolu na výskyt antibakteriálne úcinkujúcich peptidov myokardu potkanov.