title: Ten-year survey of quinolone resistance in Escherichia coli causing urinary tract infections.
abstract: In a ten-year survey (1983-1992) of quinolone resistance in Escherichia coli causing urinary tract infections in a general practice patient population, 9,934 strains were tested. Resistance increased remarkably from 1989 onwards. The rate of resistance to pipemidic acid was < or = 6% before 1989 and 18% in 1992; the rate of resistance to ciprofloxacin (MIC > or = 4 mg/l) was 0.8% in 1989 and 7.1% in 1992. Although the consumption of older quinolones decreased the total consumption of quinolones increased yearly.
authors.affiliation: Servicio de Microbiología y Unidad de Epidemiología Infecciosa, Hospital NS Aránzazu, San Sebastián, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Pérez-Trallero
authors.forename: M
authors.initials: M
authors.lastname: Urbieta
authors.forename: D
authors.initials: D
authors.lastname: Jimenez
authors.forename: J M
authors.initials: JM
authors.lastname: García-Arenzana
authors.forename: G
authors.initials: G
authors.lastname: Cilla
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000494:pharmacology / Q000627:therapeutic use; D003625:Data Collection; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008137:Longitudinal Studies; D009643:Norfloxacin / Q000494:pharmacology / Q000627:therapeutic use; D010876:Pipemidic Acid / Q000494:pharmacology / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D010876:Pipemidic Acid; D009643:Norfloxacin