title: Administration of vitamin K to newborn infants and childhood cancer.
abstract: OBJECTIVE
  To investigate whether childhood cancer is associated with intramuscular administration of vitamin K to newborn infants.
  
  
  METHODS
  Routines for administration of vitamin K to infants born after normal deliveries during 1973-89 were obtained from maternity hospitals. Occurrence of cancer up to the end of 1991 was identified by comparing these records with the national cancer registry. Adherence to the routine method of administering vitamin K was checked with the medical records of a sample of 396 infants (196 who had developed childhood cancer and 200 controls).
  
  
  METHODS
  All maternity hospitals in Sweden.
  
  
  METHODS
  1,384,424 full term infants born after non-instrumental deliveries, 1,085,654 of whom were born in units where vitamin K was routinely given by intramuscular injection and 272,080 of whom were born where it was given orally.
  
  
  METHODS
  Odds ratios for cancer after intramuscular administration of vitamin K versus oral administration after stratification for year of birth.
  
  
  RESULTS
  Adherence to routine method of administering vitamin K was 92% in the 235 cases where individual information could be found. The risk of cancer after intramuscular administration of vitamin K was not elevated compared with that after oral administration: odds ratios of 1.01 (95% confidence interval 0.88 to 1.17) for all childhood cancers and 0.90 (0.70 to 1.16) for childhood leukaemia.
  
  
  CONCLUSIONS
  The alleged association between intramuscular vitamin K prophylaxis to newborn infants and childhood cancer could not be verified in the present study of full term infants born after non-instrumental delivery.
authors.affiliation: Department of Public Health and Epidemiology, National Board of Health, Stockholm, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Ekelund
authors.forename: O
authors.initials: O
authors.lastname: Finnström
authors.forename: J
authors.initials: J
authors.lastname: Gunnarskog
authors.forename: B
authors.initials: B
authors.lastname: Källén
authors.forename: Y
authors.initials: Y
authors.lastname: Larsson
mesh_terms: D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular / Q000009:adverse effects; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D014812:Vitamin K / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014812:Vitamin K