[The effect of the calcium channel blockers cinnarizine and flunarizine on the duration of hexobarbital-induced sleep i rats].
The effect of the calcium channel blockers cinnarizine (20 mg/kg) and flunarizine (10 mg/kg) on hexobarbital sleeping time in rats has been studied. We have found that cinnarizine when applied intraperitoneally once 1 h or 4 h before hexobarbital and repeatedly for 5 days once daily prolongs sleeping time significantly. When cinnarizine has been introduced simultaneously with phenobarbital (60 mg/kg) for 5 days once daily the sleeping time that was expected to be shortened by phenobarbital only has been obtained to return to control values. Flunarizine has not been found to affect sleeping time significantly either alone or in the presence of phenobarbital. Latencies have not been altered by any of both agents.
Marazova
K D
KD
Lozeva
V G
VG
Belcheva-Beronova
A
A
D000818:Animals; D002936:Cinnarizine / Q000494:pharmacology*; D004347:Drug Interactions; D005444:Flunarizine / Q000494:pharmacology*; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D002936:Cinnarizine; D006591:Hexobarbital; D005444:Flunarizine
Vliianie blokatorov kal'tsievykh kanalov tsinnarizina i flunarizina na prodolzhitel'nost' geksobarbitalovogo sna u krys.