[Therapy of Crohn disease by immunomodulation with 7S immunoglobulins].
Immunoregulatory disturbances play an important role in pathophysiology of Crohn's disease. Because of this fact we tried to improve the situation in therapy-resistant cases by additional intravenous application of 10 g 7S-immunoglobulin (Venimmun) for 10 days. The first patient with active Crohn's disease (CDAI 209) showed a steroid-related psychosis. Therapy had to be changed. During therapy with immunoglobulin Crohn's disease activity index decreased by 97 points. Activity index fell in another patient during therapy from 363 to 150 points. Both patients came into remission by additional therapy with 7S-immunoglobulin. The number of leucocytes decreased and the number of lymphocytes increased. CD4/CD8 ratio in the peripheral blood changed in favour of suppressor cells and soluble interleukin-2 receptors were reduced. Immunoregulatory effects seem to be responsible for successful immunoglobulin therapy in Crohn's disease.
Schmidt
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C
Gastroenterologische Abteilung, Universität Bonn.
D000328:Adult; D003424:Crohn Disease / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D008297:Male
Therapie des Morbus Crohn durch Immunmodulation mit 7S-Immunoglobulinen.