title: Chromium and parenteral nutrition in children.
abstract: Chromium (Cr) dosage was assayed in i.v. nutrition, serum, and losses of five children on total parenteral nutrition for > or = 4 weeks. The Cr supply (4.7 +/- 1.2 micrograms/kg/day) was above recommended levels (0.5 microgram/kg/day). Serum (18.2 +/- 1.8 micrograms/L) and urine (37.4 +/- 10.5 micrograms/L) were also higher than control values (0.7-0.9 microgram/L and 0.2-0.8 microgram/L, respectively). Serum and urine Cr concentrations displayed a positive correlation. Serum Cr and Fe showed a negative correlation. These results confirm the potential toxicity of Cr previously reported in animals. Cr levels of i.v. nutrition solutes should be checked thoroughly.
authors.affiliation: Pédiatrie A, CHU Clémenceau, Caen, France.
authors.forename: D
authors.initials: D
authors.lastname: Bougle
authors.forename: F
authors.initials: F
authors.lastname: Bureau
authors.forename: G
authors.initials: G
authors.lastname: Deschrevel
authors.forename: C
authors.initials: C
authors.lastname: Hecquard
authors.forename: D
authors.initials: D
authors.lastname: Neuville
authors.forename: M
authors.initials: M
authors.lastname: Drosdowsky
authors.forename: J F
authors.initials: JF
authors.lastname: Duhamel
mesh_terms: D002648:Child; D002857:Chromium / Q000008:administration & dosage* / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism; D010288:Parenteral Nutrition
chemical_list: D002857:Chromium; D007501:Iron