Chromosome 22 monosomy in a radiation-induced meningioma.
We report for the first time on the cytogenetics of a radiation-induced meningioma, in a patient without neurofibromatosis. Chromosome 22 monosomy was found in more than 50% of the cells examined. These findings seem to suggest that the same kind of chromosomal aberrations are found in both "idiopathic" and radiation-induced meningiomas and that a common etiopathogenetic mechanism might be at work in meningiomas of whatever origin.
Pagni
C A
CA
Istituto di Neurochirurgia, Università di Torino.
Canavero
S
S
Fiocchi
F
F
Ponzio
G
G
D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*