Hepatic candidiasis: persistent pyrexia in a patient with acute myeloid leukaemia after recovery from consolidation therapy-induced neutropenia.
Fever, a frequent manifestation in acute leukaemia patients who develop treatment-induced neutropenia, usually resolves when the neutrophil count returns to normal irrespective of whether an infective agent is isolated or not. A persistent pyrexia following neutrophil recovery and associated with multiple negative microbiological cultures should signal a careful search for a deep-seated fungal infection in any leukaemic patient who is complete remission. We report here a 39-year-old Chinese man with acute myeloid leukaemia in first complete remission whose unresolved fever after recovery from consolidation therapy-induced neutropenia was ultimately confirmed to be caused by focal hepatic candidal microabscesses by an open liver biopsy.
Ong
S T
ST
Department of Medicine, National University of Singapore.
Kueh
Y K
YK
D000328:Adult; D000677:Amsacrine / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001706:Biopsy; D002177:Candidiasis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D003596:Cytosine / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005334:Fever / Q000209:etiology*; D015725:Fluconazole / Q000627:therapeutic use; D005490:Focal Infection / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000188:drug therapy*; D008107:Liver Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009503:Neutropenia / Q000139:chemically induced* / Q000150:complications; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
D000677:Amsacrine; D005047:Etoposide; D003596:Cytosine; D015725:Fluconazole