Lignified materials as medicinal resources. VI. Anti-HIV activity of dehydrogenation polymer of p-coumaric acid, a synthetic lignin, in a quasi-in-vivo assay system as an intermediary step to clinical trials.
After the dehydrogenation polymer of p-coumaric acid, a synthetic lignin, was intravenously injected into mice, the serum was collected immediately, 15 min, 1 h, 5 h, and 24 h after the injection. The serum thus obtained was added to the assay medium containing MT-4 cells infected with HTLV-IIIB (an HIV-1 strain). Inhibition of the cytopathogenicity of HIV by these serum preparations was assayed by the MTT method. The result revealed that lignins could be a promising class of anti-HIV agents with an unidentified unique mode of action.
Shimizu
N
N
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Naoe
T
T
Kawazoe
Y
Y
Sakagami
H
H
Nakashima
H
H
Murakami
T
T
Yamamoto
N
N
D000998:Antiviral Agents / Q000097:blood / Q000494:pharmacology*; D002478:Cells, Cultured; D003373:Coumaric Acids / Q000097:blood / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D011108:Polymers / Q000494:pharmacology*; D011422:Propionates
D000998:Antiviral Agents; D003373:Coumaric Acids; D011108:Polymers; D011422:Propionates; C495469:p-coumaric acid