A high resolution deletion map of human chromosome Xp22.
We have developed a 32-interval deletion panel for human chromosome Xp22 spanning about 30 megabases of genomic DNA. DNA samples from 50 patients with chromosomal rearrangements involving Xp22 were tested with 60 markers using a polymerase chain reaction strategy. The ensuing deletion map allowed us to confirm and refine the order of previously isolated and newly developed markers. Our mapping panel will provide the framework for mapping new sequences, for orienting chromosome walks in the region and for projects aimed at isolating genes responsible for diseases mapping to Xp22.
Schaefer
L
L
Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.
Ferrero
G B
GB
Grillo
A
A
Bassi
M T
MT
Roth
E J
EJ
Wapenaar
M C
MC
van Ommen
G J
GJ
Mohandas
T K
TK
Rocchi
M
M
Zoghbi
H Y
HY
Ballabio
A
A
D001483:Base Sequence; D002460:Cell Line; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017384:Sequence Deletion; D016324:Sequence Tagged Sites; D014960:X Chromosome
D015342:DNA Probes; D005819:Genetic Markers; D004247:DNA