8;21 translocation and multilineage involvement.
The translocation (8;21)(q22;q22) is commonly associated with acute myeloid leukemia (AML) M2 according to the French-American-British (FAB) classification. We describe 11 cases of t(8;21) diagnosed by strict FAB criteria. Six cases were diagnosed as AML M2, 3 cases as AML M4, 1 case as refractory anemia with excess of blasts in transformation, and 1 case as Philadelphia chromosome negative chronic myeloid leukemia in acceleration. Translocation (8;21) could thus occur in a wider variety of hematological abnormalities. Accordingly, we propose that t(8;21) may involve different hemopoietic lineages.
Kwong
Y L
YL
University Department of Pathology, Queen Mary Hospital, Hong Kong.
Ching
L M
LM
Liu
H W
HW
Lee
C P
CP
Pollock
A
A
Chan
L C
LC
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002648:Child; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic