Intrinsic alterations of diaphragm muscle in experimental cardiomyopathy.
Diaphragmatic function was investigated in the cardiomyopathic Syrian hamster (CSH) from the dilated Bio 53:58 strain, after long-term therapy with the angiotensin-converting enzyme inhibitor perindopril. Twenty-two 1-month old CSHs were treated during a 5-month period by either oral gavage with perindopril (1 mg/kg/day) (n = 11) or placebo (n = 11). Control hamsters from the F1B strain received placebo (n = 7). Mechanical properties were studied in isolated diaphragm strips electrically stimulated in both twitch and tetanic conditions. Compared with F1B control hamsters, peak active tension and positive (+dP/dtmax) and negative (-dP/dtmax) peaks of isometric tension derivative were significantly depressed in placebo treated CSHs. Compared with placebo-treated CSHs, peak active tension was significantly higher in perindopril-treated CSHs in both twitch (25 +/- 4 vs 16 +/- 1 mN/mm2; p < 0.01) and tetanus modes (56 +/- 4 vs 38 +/- 2 mN/mm2; p < 0.01). Moreover, +dP/dtmax and -dP/dtmax were improved significantly in twitch (p < 0.01 and p < 0.01, respectively) and tetanus modes (p < 0.05 and p < 0.01, respectively). We conclude that, in the CSH, long-term therapy with the angiotensin-converting enzyme inhibitor perindopril helped to preserve the diaphragmatic function.
Lecarpentier
Y
Y
Service de Physiologie UFR, Centre Hospitalier Universitaire de Bicêtre, Le Kremlin-Bicêtre, France.
Pery
N
N
Coirault
C
C
Scalbert
E
E
Desche
P
P
Suard
I
I
Lambert
F
F
Chemla
D
D
D000110:Acetylcholinesterase / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D001696:Biomechanical Phenomena; D006224:Cricetinae; D003964:Diaphragm / Q000187:drug effects* / Q000503:physiopathology; D006333:Heart Failure / Q000201:enzymology / Q000503:physiopathology / Q000517:prevention & control*; D007211:Indoles / Q000627:therapeutic use*; D007537:Isometric Contraction / Q000187:drug effects; D020913:Perindopril
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D000110:Acetylcholinesterase; D020913:Perindopril