title: DNA ploidy of basal cell carcinoma determined by image cytometry of fresh smears.
abstract: Image analysis of nuclear DNA content (DNA ploidy) was performed on smears of basal cell carcinoma (BCC) obtained during Mohs microscopically-controlled surgery from 51 tumors. DNA ploidy was compared with histologic growth pattern and the contour of the invading edge. There was a statistically significantly increased frequency of DNA aneuploidy in smears from BCC exhibiting partial or total diffuse (infiltrative and superficial multicentric) growth patterns (80%; 32 of 40) as compared to solely circumscribed growth patterns (0%; 0 of 11) (p < 0.001).
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Herzberg
authors.forename: J A
authors.initials: JA
authors.lastname: Garcia
authors.forename: B J
authors.initials: BJ
authors.lastname: Kerns
authors.forename: P A
authors.initials: PA
authors.lastname: Jordan
authors.forename: J C
authors.initials: JC
authors.lastname: Pence
authors.forename: S M
authors.initials: SM
authors.lastname: Rotter
authors.forename: L M
authors.initials: LM
authors.lastname: Dzubow
mesh_terms: D000782:Aneuploidy; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D005434:Flow Cytometry; D006801:Humans; D007091:Image Processing, Computer-Assisted; D011003:Ploidies; D012878:Skin Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm