[A preliminary cytogenetic study of uterine leiomyoma].
Thirty fresh samples of uterine leiomyoma were disaggregated in collagenase (200kU/L) and cultured for 3-10 days with incubator. Of 30 cases, 27 cases of uterine leiomyoma obtained karyotypes and the rate of successful cultured was 90%, 9 cases showed abnormal karyotypes. Structural changes were frequently seen. Breakpoint of chromosome were 12q13-15 (7 cases), 14q24 (6 cases), 7q31-32 (3 cases). Specific chromosomal rearrangements were t(12;14) (q13-15; q24) and del (7) (q31-32). Our data suggested that chromosome 12q13-15, 14q24, 7q31-32 may be related to the proliferation of uterine leiomyoma.
Xiu
Z F
ZF
Nanjing Gu-lou Hospital.
D000328:Adult; D000368:Aged; D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology