Intestinal permeability to [51Cr]EDTA in infectious diarrhea.
Orally administered [51Cr]EDTA was used to measure intestinal permeability in subjects with infectious diarrhea and in those without gastrointestinal complaints. [51Cr]EDTA was given to 87 subjects: 63 controls (32 normal controls, and 31 disease controls), and 24 patients with infectious diarrhea. Approximately 100 microCi of [51Cr]EDTA was given orally after an overnight fast. Urine was collected for the following 24 hr. Intestinal permeability to [51Cr]EDTA in both normal volunteers and in patients with a variety of diseases not associated with intestinal injury was low and results were in a relatively narrow range. Mean 24-hr urinary excretion of [51Cr]EDTA, calculated as a percent of the administered dose, in controls was 1.6% (0.2-3.5%). Patients with infectious diarrhea associated with invasive pathogens and/or intestinal inflammation had increased excretion of [51Cr]EDTA (mean 6.1%, P < 0.0001), with elevated excretions in 75%. These results demonstrate that intestinal infections must be considered as possible causes for increased intestinal permeability as assessed by the [51Cr]EDTA test.
Zuckerman
M J
MJ
Department of Medicine, Texas Tech University Health Sciences Center, El Paso 79905.
Watts
M T
MT
Bhatt
B D
BD
Ho
H
H
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002860:Chromium Radioisotopes; D003967:Diarrhea / Q000378:metabolism*; D004492:Edetic Acid / Q000493:pharmacokinetics*; D005260:Female; D005759:Gastroenteritis / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010539:Permeability
D002860:Chromium Radioisotopes; D004492:Edetic Acid