title: [Charcoal and isoflurane alveolar washout in low-flow circuit].
abstract: The inclusion of charcoal filters in anaesthetic low-flow systems contributes to the acceleration of the kinetics of isoflurane (Forane). In twenty subjects, scheduled for extra- and intracranial surgery, ventilated with a low-flow system (Ohmeda Excel OAV7750 with rebreathing cassette) with a mean total flow of 0.7 l/min, awakening was complete within 5 minutes from stopping isoflurane and including charcoal in the circuit. At the awakening, the expiratory concentration of isoflurane was 0.23% (95% confidence intervals: 0.19-0.27%): these values are similar to those of MACawake of isoflurane after fast alveolar washout. The use of charcoal during low-flow anaesthesia makes low-flow systems more flexible in their use; the anaesthetic level is more easily controllable and accidental overdosing of volatile anaesthetics can be immediately removed.
authors.affiliation: Istituto Polidisciplinare di Anestesia, Rianimazione e Terapia Antalgica, Università degli Studi di Trieste.
authors.forename: E
authors.initials: E
authors.lastname: Romano
authors.forename: M
authors.initials: M
authors.lastname: Pegoraro
authors.forename: A
authors.initials: A
authors.lastname: Vacri
authors.forename: C
authors.initials: C
authors.lastname: Pecchiari
authors.forename: E
authors.initials: E
authors.lastname: Auci
mesh_terms: D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation / Q000295:instrumentation* / Q000379:methods; D002606:Charcoal; D005260:Female; D005374:Filtration; D006801:Humans; D007530:Isoflurane / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli
chemical_list: D002606:Charcoal; D007530:Isoflurane
vernacular_title: Carboni attivi e washout alveolare dell'isofluorano in circuito a basso flusso.