title: Cross-sectional and longitudinal analyses of stimulated parotid salivary constituents in healthy, different-aged subjects.
abstract: BACKGROUND
  Salivary gland dysfunction has traditionally been associated with old age, and complaints of xerostomia are common in an elderly population. Measurement of certain salivary constituents can provide information about the functional ability of discrete areas of the salivary gland. To our knowledge, this is the first longitudinal study to examine levels of salivary constituents in stimulated parotid saliva in a population of different-aged persons.
  
  
  METHODS
  The levels of five salivary constituents (total protein, lactoferrin, proline-rich proteins, sodium, and potassium) were measured in stimulated parotid saliva of 47 healthy, unmedicated men and women over a 10.5 year period.
  
  
  RESULTS
  There were no significant age-related decreases in the presence of total protein, lactoferrin, proline-rich proteins, sodium, and potassium in this exocrine secretion.
  
  
  CONCLUSIONS
  These data confirm and extend previous cross-sectional studies of salivary constituents, indicating that parotid gland function is maintained in healthy aging individuals.
authors.affiliation: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland.
authors.forename: A J
authors.initials: AJ
authors.lastname: Wu
authors.forename: J C
authors.initials: JC
authors.lastname: Atkinson
authors.forename: P C
authors.initials: PC
authors.lastname: Fox
authors.forename: B J
authors.initials: BJ
authors.lastname: Baum
authors.forename: J A
authors.initials: JA
authors.lastname: Ship
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007781:Lactoferrin / Q000032:analysis; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000378:metabolism*; D011188:Potassium / Q000032:analysis; D011392:Proline / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D012964:Sodium / Q000032:analysis
chemical_list: D011506:Proteins; D011392:Proline; D012964:Sodium; D007781:Lactoferrin; D011188:Potassium