Cigarette smoke exposure of school children: effect of passive smoking and vitamin E supplementation on blood antioxidant status.
Despite similar vitamin E concentrations, erythrocytes of 25 children of smoking parents had an increased tendency (p < 0.01) to peroxidize in vitro as compared with those of 28 children of nonsmoking parents. This difference was abolished by vitamin E supplementation (100 mg alpha-tocopherol acetate/day for 14 days). The increased susceptibility to erythrocyte peroxidation in the smokers may reflect lower erythrocyte glucose-6-phosphate dehydrogenase, glutathione peroxidase and superoxide dismutase activities (p < 0.001, p < 0.005, and p < 0.02, respectively) in children of smoking parents. Children of smoking parents seem to be under sustained oxidant stress with increased plasma-conjugated dienes (p < 0.01) and dehydroascorbate (p < 0.002) concentrations. Total plasma cholesterol was similar in children of smoking and nonsmoking parents, and was unaffected by vitamin E supplementation. Indices of sustained oxidant stress in children of smoking parents were partially ameliorated by vitamin E supplementation.
Jendryczko
A
A
Department of Drug Chemistry, Medical School in Katowice, Sosnowiec, Poland.
Szpyrka
G
G
Gruszczyński
J
J
Kozowicz
M
M
D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D002214:Capsules; D002374:Catalase / Q000097:blood; D002648:Child; D002784:Cholesterol / Q000097:blood; D003683:Dehydroascorbic Acid / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D000975:Antioxidants; D002214:Capsules; D017392:Thiobarbituric Acid Reactive Substances; D014028:Tobacco Smoke Pollution; D014810:Vitamin E; D002784:Cholesterol; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid