title: Clinicopathologic study of 212 cases of peripheral T-cell lymphoma among the Japanese.
abstract: BACKGROUND
  Postthymic/peripheral T-cell malignancy shows significant histopathologic and clinical diversity, even in its prognosis, and the correlations remain to be debated.
  
  
  METHODS
  The clinicopathologic features of 212 Japanese patients with these neoplasms were investigated.
  
  
  RESULTS
  There were 131 male and 81 female patients, whose ages ranged from 2 to 90 years (mean, 51.7 years). Lymphadenopathy was the most frequent clinical presentation, and the patients also had frequent skin lesions, hyperimmunoglobulinemia, hypercalcemia, and a rapid clinical course. Furthermore, the differences in the histologic features of each subcategory reflected the clinical pictures. The immunophenotypic analysis was indispensable in establishing a correct diagnosis, and the high-grade tumors often showed loss of pan-T antigens.
  
  
  CONCLUSIONS
  The histopathologic classification proposed by Suchi et al., which has been incorporated into the updated Kiel classification, showed a good prognostic correlation.
authors.affiliation: Department of Pathology, Aichi Cancer Center Hospital, Nagoya, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Suchi
authors.forename: T
authors.initials: T
authors.lastname: Koshikawa
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Oyama
authors.forename: M
authors.initials: M
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Motoori
authors.forename: R
authors.initials: R
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000145:classification / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D015996:Survival Rate
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015481:HTLV-I Antibodies; D011948:Receptors, Antigen, T-Cell