title: Facial thermography during nasal provocation tests with histamine and allergen.
abstract: Changes of skin temperature (T degree) of the nose area during nasal provocation tests with histamine and allergen were followed by means of an infrared thermography camera. By a colimator system in which temperatures measured on a given surface can be integrated and averaged, thermography allows the continuous and quantitative recording of the temperature during the whole procedure in a completely noninvasive way. In 10 normal subjects, increasing doses of histamine induced a dose-dependent rise of the nose external temperature. No significant change was observed with the vehicle solution. In six subjects allergic to grass pollen, the nebulization of increasing concentrations of a pollen extract induced a dose-dependent rise in T degree. The T degree rise observed after histamine or allergen corresponded to a marked nasal obstruction. The nebulization of the highest dose of the pollen extract did not induce any T degree rise in six nonallergic subjects. The continuous recording of the skin temperature by a noninvasive method might yield additional information on the vascular changes rapidly occurring during nasal challenges.
authors.affiliation: Division of Immunology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Seppey
authors.forename: C
authors.initials: C
authors.lastname: Hessler
authors.forename: M
authors.initials: M
authors.lastname: Bruchez
authors.forename: M
authors.initials: M
authors.lastname: Savary
authors.forename: A
authors.initials: A
authors.lastname: Pécoud
mesh_terms: D000328:Adult; D000485:Allergens / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005145:Face; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009299:Nasal Provocation Tests; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000503:physiopathology; D012881:Skin Temperature
chemical_list: D000485:Allergens; D006632:Histamine