title: Development of periapical lesions.
abstract: The purpose of the present study was to follow the development of periapical lesions both radiographically and histologically in infected teeth with open and sealed root canals. The mandibular premolars from five adult monkeys were used in the experiment. Sealed infected teeth developed radiographic signs of periapical pathosis significantly earlier than unsealed teeth. Although, histological signs of pathology could be seen periapically at earlier observation periods, sealed teeth consistently developed these changes earlier than unsealed teeth. Furthermore, the histological periapical pathology differed somewhat between the two groups in that unsealed teeth showed a multi-focal diffuse pattern of spreading.
authors.affiliation: Department of Oral Histology and Cell Biology, School of Dentistry, Karolinska Institutet, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Jansson
authors.forename: H
authors.initials: H
authors.lastname: Ehnevid
authors.forename: S
authors.initials: S
authors.lastname: Lindskog
authors.forename: L
authors.initials: L
authors.lastname: Blomlöf
mesh_terms: D000818:Animals; D003773:Dental Plaque / Q000382:microbiology; D003786:Dental Pulp Cavity / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D006097:Granulation Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D008252:Macaca fascicularis; D009336:Necrosis; D010483:Periapical Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D010484:Periapical Granuloma / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D010486:Periapical Tissue / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D011842:Radicular Cyst / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D011859:Radiography; D012389:Root Canal Obturation; D015035:Zinc Oxide-Eugenol Cement
chemical_list: D015035:Zinc Oxide-Eugenol Cement