title: Lachnumon and lachnumol a, new metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. I. Producing organism, fermentation, isolation and biological activities.
abstract: Several chlorinated metabolites with nematicidal, antimicrobial, and cytotoxic activities were isolated from submerged cultures of the ascomycete Lachnum papyraceum. Three compounds were identified as (+)-mycorrhizin A (3), (+)-chloromycorrhizin A (4) and (+)-dechloromycorrhizin A (5). The occurrence of 5 as a natural product is new. Two compounds, lachnumon (1) and lachnumol A (2), were found to be new fungal metabolites with cytotoxic, nematicidal and antimicrobial activities.
authors.affiliation: Universität Kaiserslautern, Lehrbereich Biotechnologie, Fed. Rep. Germany.
authors.forename: M
authors.initials: M
authors.lastname: Stadler
authors.forename: H
authors.initials: H
authors.lastname: Anke
authors.forename: W R
authors.initials: WR
authors.lastname: Arendholz
authors.forename: F
authors.initials: F
authors.lastname: Hansske
authors.forename: U
authors.initials: U
authors.lastname: Anders
authors.forename: O
authors.initials: O
authors.lastname: Sterner
authors.forename: K E
authors.initials: KE
authors.lastname: Bergquist
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification*; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003511:Cyclohexanols / Q000302:isolation & purification*; D003512:Cyclohexanones / Q000302:isolation & purification*; D004852:Epoxy Compounds / Q000302:isolation & purification*; D005285:Fermentation; D007939:Leukemia L1210; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000935:Antifungal Agents; D000969:Antinematodal Agents; D003511:Cyclohexanols; D003512:Cyclohexanones; D004852:Epoxy Compounds; C082435:lachnumon; C082436:lachnumol A