Efficacy of monoclonal antibodies against adhesion molecules in animal models of asthma.
Cell surface adhesive glycoproteins are principal regulators of nearly all aspects of immune/inflammatory responses. Using monoclonal antibodies to individual adhesion molecules, the expression and contribution of specific molecules in the pathogenesis of allergen-induced airway hyperresponsiveness in monkeys has been deciphered. Results confirm the importance of cell adhesion and demonstrate that antagonism of a single adhesion molecule may provide a novel therapeutic approach.
Wegner
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Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
Gundel
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RH
Letts
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LG
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001249:Asthma / Q000628:therapy*; D015815:Cell Adhesion Molecules / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000628:therapy; D008992:Monkey Diseases / Q000628:therapy; D011323:Primates; D009626:Terminology as Topic
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules