title: Acetylsalicylic acid has no effects on various isolated immune cells in vitro.
abstract: In addition to the well known biological effects of acetylsalicylic acid (ASA), its stimulating effect on the immune system has recently been described. In the present study, therefore, the influence of ASA on isolated leucocytes was investigated in vitro. Various concentrations of ASA, representing therapeutic concentrations, had neither an inhibitory nor a stimulating influence on the cytotoxicity of CD16-positive cells. The phytohaemagglutinin-induced proliferation of lymphocytes and the phagocytosis activity of monocytes and neutrophilic granulocytes was similarly unaffected. These results would indicate that the immunostimulating effects already described for ASA cannot be examined in isolated leucocytes in vitro and should be attributed to an interaction of various effector cells in vivo.
authors.affiliation: Institut für Immunbiologie, Universität Köln, Cologne, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Uhlenbruck
authors.forename: H
authors.initials: H
authors.lastname: Lötzerich
authors.forename: J
authors.initials: J
authors.lastname: Bernhardt
authors.forename: K
authors.initials: K
authors.lastname: Rogalla
mesh_terms: D001241:Aspirin / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects
chemical_list: D001241:Aspirin