Trifluoperazine inhibition of insulin-induced increase in skeletal muscle glucose uptake.
The ability of trifluoperazine, a calmodulin blocker, to prevent increases in skeletal muscle glucose uptake induced by insulin was tested. Insulin significantly increased glucose uptake by the rat hindlimb and trifluoperazine (10(-6) M) completely inhibited this increase. We conclude that calmodulin is a factor involved in the regulation of insulin-mediated glucose transport in muscle cells.
Guarner
V
V
Departamento de Fisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Hernández
E H
EH
Huerto
R
R
Gorostiza
P
P
Valenzuela
F
F
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002147:Calmodulin / Q000037:antagonists & inhibitors; D005947:Glucose / Q000378:metabolism*; D006614:Hindlimb / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007329:Insulin Antagonists / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014268:Trifluoperazine / Q000494:pharmacology*
D001786:Blood Glucose; D002147:Calmodulin; D007328:Insulin; D007329:Insulin Antagonists; D014268:Trifluoperazine; D005947:Glucose