Potential indications for octreotide in gastroenterology: summary of workshop.
The potential therapeutic applications of somatostatin and octreotide in gastroenterology involve gut neuro-endocrine tumours, bleeding varices, bleeding peptic ulcers, gastro-intestinal fistulae, pancreatic fistulae, dumping syndrome, pancreatic pseudocysts, short bowel syndrome, acute pancreatitis, AIDS-related diarrhoea, intestinal subacute obstruction, idiopathic 'diarrhoea', irritable bowel syndrome and GIT tumours. Octreotide has a longer duration of action than somatostatin and can be administered by subcutaneous injection, thus making it suitable for long-term administration. Many of the potential gastro-intestinal indications require long-term administration and thus octreotide would be the agent of choice.
Burroughs
A K
AK
Hepatobiliary and Liver Transplantation Unit, Royal Free Hospital and School of Medicine, London, UK.
Malagelada
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D003109:Colonic Diseases, Functional / Q000188:drug therapy; D003967:Diarrhea / Q000188:drug therapy; D004377:Dumping Syndrome / Q000188:drug therapy; D004932:Esophageal and Gastric Varices / Q000188:drug therapy; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006801:Humans; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use*; D010182:Pancreatic Diseases / Q000188:drug therapy*; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy; D012778:Short Bowel Syndrome / Q000188:drug therapy; D013997:Time Factors
D015282:Octreotide