Carcinosarcoma of the adrenal cortex presenting with mineralocorticoid excess.
An adrenal carcinosarcoma is reported in a 79-year-old woman presenting with clinical signs of hyperaldosteronism. The tumor weighed 199 g and consisted of areas typical of adrenal carcinoma and areas of sarcoma. The sarcomatous component of the tumor showed osteogenic and chondroid differentiation. Vimentin stained both the carcinomatous and sarcomatous regions. Four months after resection, the patient developed metastases. This is the third reported case of adrenal carcinosarcoma and the only case in which hyperaldosteronism or bony differentiation was observed.
Barksdale
S K
SK
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20894.
Marincola
F M
FM
Jaffe
G
G
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000368:Aged; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications; D007150:Immunohistochemistry; D008901:Mineralocorticoids / Q000096:biosynthesis*
D008901:Mineralocorticoids