Sequence homology between a bacterial metalloproteinase and eukaryotic matrix metalloproteinases.
The origin and evolution of matrix metalloproteinases represent an exciting subject of study. Recently, various reports have searched for a relationship between bacterial and eukaryotic metalloproteinases. In this report, we constructed a phylogenetic tree using the amino acid sequence of one bacterial metalloproteinase and eight eukaryotic matrix metalloproteinases and performed multiple alignments with some of these sequences. We concluded that there is a familial relationship between members of the four major branches represented in the tree.
de Souza
S J
SJ
Brentani
R
R
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry*; D017364:Collagenases / Q000737:chemistry / Q000145:classification; D016974:Dickeya chrysanthemi / Q000235:genetics; D053507:Matrix Metalloproteinase 11; D008666:Metalloendopeptidases / Q000737:chemistry*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011817:Rabbits / Q000235:genetics; D012617:Sea Urchins / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software; D013045:Species Specificity
D001426:Bacterial Proteins; D017364:Collagenases; D053507:Matrix Metalloproteinase 11; D008666:Metalloendopeptidases; C082635:metalloprotease B, Erwinia chrysanthemi; C024344:envelysin