title: [Effect of dimethicone on pharmacokinetics and pharmacodynamics of ethyl biscoumacetate].
abstract: The influence of dimeticone (Gel de Polysilane Midy) on the pharmacokinetics and pharmacodynamics of oral ethyl biscoumacetate was studied in 6 healthy volunteers in a randomised single dose, two-way cross-over study. Each volunteer received at one week interval a single dose (300 mg) of ethyl biscoumacetate, either alone or with dimeticone. Ethyl biscoumacetate levels were measured in plasma for 24 hours. Pharmacodynamic parameters were measured for 96 hours. Ethyl biscoumacetate peak concentration was significantly higher when administered with dimeticone (40.3 +/- 25.3 mg/l vs 31.0 +/- 25.7 mg/l; p = 0.031), without significant change in the area under curve. Other pharmacokinetic and pharmacodynamic parameters did not differ significantly. The slight increase of the ethyl biscoumacetate bioavailability with dimeticone in repeated dosing might have pharmacodynamic consequence; a clinical trial should address this question.
authors.affiliation: Institut de Recherche Thérapeutique (IRT-Eclimed), Hôpital Cochin, Paris.
authors.forename: X
authors.initials: X
authors.lastname: Copie
authors.forename: J L
authors.initials: JL
authors.lastname: Pinquier
authors.forename: M
authors.initials: M
authors.lastname: Letrait
authors.forename: M H
authors.initials: MH
authors.lastname: Paltiat
authors.forename: J Y
authors.initials: JY
authors.lastname: Pello
authors.forename: E
authors.initials: E
authors.lastname: Rey
authors.forename: G
authors.initials: G
authors.lastname: Chanteclair
authors.forename: D
authors.initials: D
authors.lastname: de Lauture
authors.forename: G
authors.initials: G
authors.lastname: Olive
authors.forename: G
authors.initials: G
authors.lastname: Strauch
mesh_terms: D000328:Adult; D005017:Ethyl Biscoumacetate / Q000493:pharmacokinetics* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012841:Simethicone / Q000494:pharmacology*
chemical_list: D005017:Ethyl Biscoumacetate; D012841:Simethicone
vernacular_title: Effet du diméticone sur la pharmacocinétique et la pharmacodynamie du biscoumacétate d'éthyle.