Antiribosomal P protein antibodies in different populations of patients with systemic lupus erythematosus.
We report a significantly increased prevalence of antiribosomal P protein antibodies in Malaysian Chinese patients (38%) with SLE compared to white Caucasian (13%) and Afro-Caribbean (20%) patients. The increased prevalence was not due to a generalized increase in autoantibody production because anti-dsDNA and anti-SSA antibodies were present in comparable frequencies in the three ethnic groups while anti-Sm and anti-SSB antibodies were rarely found in the Malaysian Chinese patients.
Teh
L S
LS
Rheumatology Research Centre, University Hospital of Wales, Heath Park, Cardiff.
Lee
M K
MK
Wang
F
F
Manivasagar
M
M
Charles
P J
PJ
Nicholson
G D
GD
Hay
E M
EM
Isenberg
D A
DA
Amos
N
N
Williams
B D
BD
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis*; D044466:Asian People; D044383:Black People; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000235:genetics / Q000276:immunology*; D015800:Protozoan Proteins; D012269:Ribosomal Proteins / Q000276:immunology*; D044465:White People
D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins