[The enhancement of immune suppression by local laser irradiation in rats exposed to cyclophosphane].
The authors experimentally studied where low-energy laser radiation (LELR) can be used to enhance cyclophosphanum-induced immunodepression. Preliminary LELR of the adrenal region and cyclophosphanum, 4 mg/kg, resulted in a more profound decrease in the intensity of a primary immune response as compared to the controls received a pseudoradiation and the cytostatic in the same dosage. The findings suggest that laser radiation can be applied to the adrenal region in the clinical setting to reduce a dose of the cytostatic administered and hence adverse effects, by preserving the therapeutical level of immunodepression.
Konchugova
T V
TV
Pershin
S B
SB
Minenkov
A A
AA
D000311:Adrenal Glands; D000818:Animals; D001921:Brain; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007108:Immune Tolerance / Q000187:drug effects* / Q000528:radiation effects*; D007114:Immunization; D007834:Lasers; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects
D003520:Cyclophosphamide
Usilenie immunnoĭ supressii lokal'nymi lazernymi oblucheniiami u krys, podvergnutykh vozdeĭstviiu tsiklofosfana.