[The inhibition of bile acid synthesis in cultured rabbit hepatocytes by bezafibrate].
Primary culture of rabbit hepatocytes was used for study the influence of hypolipidemic drug bezafibrate on bile acid production. Bezafibrate inhibits bile acid synthesis from endogenous and exogenous (lipoprotein) cholesterol at concentration range 1-10 micrograms/ml. Such inhibitory action of bezafibrate on bile acid synthesis should be kept in mind while applying hypolipidemic treatment.
Novikov
D K
DK
Kosykh
V A
VA
Repin
V S
VS
D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D002250:Carbon Radioisotopes; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013997:Time Factors
D001647:Bile Acids and Salts; D002250:Carbon Radioisotopes; D001629:Bezafibrate
Ingibirovanie sinteza zhelchnykh kislot v kul'tiviruemykh gepatotsitakh krolika bezafibratom.