Complement component C3-derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation.
Two neutrophil chemotactic factors have been purified from the exudate of chronic-phase of rat carrageenin-induced inflammation. Both the factors were derived from the third component of complement (C3); one was an NH2-terminal fragment (C3a) of alpha chain of C3 and another chemoattractant was a COOH-terminal fragment of beta chain, which was referred to as C3 beta c, on the basis of their molecular masses and NH2-terminal amino acid sequences. C3a exhibits potent chemotactic activity for rat neutrophils, and C3 beta c is a novel basic neutrophil chemoattractant with molecular mass of about 11 kDa, suggesting that both chemoattractants play a role in the neutrophil infiltration into inflammatory site of carrageenin-induced inflammation in rats.
Nakagawa
H
H
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Komorita
N
N
D000595:Amino Acid Sequence; D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D002630:Chemotactic Factors / Q000302:isolation & purification*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D003176:Complement C3 / Q000302:isolation & purification / Q000378:metabolism*; D015926:Complement C3a / Q000302:isolation & purification / Q000378:metabolism; D003179:Complement C3b; D006097:Granulation Tissue / Q000737:chemistry*; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000502:physiology*; D010446:Peptide Fragments / Q000302:isolation & purification / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
C082625:C3 beta c; D002630:Chemotactic Factors; D003176:Complement C3; D010446:Peptide Fragments; D015926:Complement C3a; D003179:Complement C3b; D002351:Carrageenan