Higher relative risk of spondyloarthropathies among B27 positive Indonesian Chinese than native Indonesians.
We assessed the prevalence of HLA-B27 among ethnic Indonesian and Indonesian Chinese patients with ankylosing spondylitis (AS) or related spondyloarthropathies, and also among healthy controls. HLA-B27 was found in 23 (62.2%) of 37 Chinese patients and 4% of 176 Chinese healthy controls (p < 0.001). In contrasts only 2 (8.3%) of 24 native Indonesian patients and 13 (9%) of 145 healthy controls were HLA-B27+, indicating the lack of association of HLA-B27 with spondyloarthropathies in native Indonesians. These findings also suggest that HLA-B27 Chinese Indonesians carry a greater relative risk of developing AS and related spondyloarthropathies than native Indonesians, although the prevalence of HLA-B27 in the general population is more than 2 times higher in native Indonesians.
Nasution
A R
AR
Department of Medicine, University of Indonesia, Jakarta.
Mardjuadi
A
A
Suryadhana
N G
NG
Daud
R
R
Muslichan
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000208:ethnology; D003430:Cross-Sectional Studies; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000453:epidemiology / Q000276:immunology; D012307:Risk Factors; D013122:Spinal Diseases / Q000453:epidemiology / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology*
D015796:HLA-B27 Antigen