title: Early diagnosis of prostatic carcinoma may be achieved through in vitro culture of tumor cells harvested by prostatic massage.
abstract: As a new method for early diagnosis of prostatic carcinoma we succeeded in growing in vitro the epithelial cells which can be collected from prostatic fluid after rectal prostatic massage. We report here the updated and statistically analyzed series of data (174 patients) on this new approach, which allows all the harvested cells to express their biological features. The method reaches a sensitivity of 72-86% and a specificity of 88-100%. This noninvasive test, which is also suitable for mass screening, may be very useful for an early diagnosis of the neoplasm.
authors.affiliation: Department of Experimental Medicine, University of L'Aquila Medical School, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bologna
authors.forename: C
authors.initials: C
authors.lastname: Vicentini
authors.forename: G
authors.initials: G
authors.lastname: Corrao
authors.forename: C
authors.initials: C
authors.lastname: Festuccia
authors.forename: P
authors.initials: P
authors.lastname: Muzi
authors.forename: A
authors.initials: A
authors.lastname: Tubaro
authors.forename: L
authors.initials: L
authors.lastname: Biordi
authors.forename: L
authors.initials: L
authors.lastname: Miano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004848:Epithelium / Q000473:pathology; D005189:False Positive Reactions; D006801:Humans; D008297:Male; D008405:Massage; D008875:Middle Aged; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013048:Specimen Handling; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000473:pathology