title: Surgical intervention for complications caused by late radiation damage of the small bowel: a retrospective analysis.
abstract: We studied the records of 46 patients who had been operated on between 1974 and 1990 in The Netherlands Cancer Institute because of complications due to late radiation damage of the small bowel. Data were collected on preoperative history, surgical intervention, postoperative complications and survival. By means of Cox's proportional hazards regression analysis we sought to identify factors that contribute to complication-risk and survival. The following factors led to an increase in complication-risk: hypoalbuminemia, more than one laparotomy prior to irradiation and a short interval (< 12 months) between irradiation and surgical intervention. The following factors related to a poorer survival: incomplete resection of the primary tumor and a short interval (< 12 months) between irradiation and surgical intervention. The type of surgical intervention did not have cumulative prognostic value in relation to complication-risk or survival. As patients undergoing resections differed considerably from patients undergoing bypass-procedures, no conclusions could be drawn about the superiority of one technique over the other. We think that both types of intervention have their own field of indication.
authors.affiliation: Department of Surgery, Netherlands Cancer Institute, Amsterdam.
authors.forename: H K
authors.initials: HK
authors.lastname: van Halteren
authors.forename: E
authors.initials: E
authors.lastname: Gortzak
authors.forename: B G
authors.initials: BG
authors.lastname: Taal
authors.forename: T J
authors.initials: TJ
authors.lastname: Helmerhorst
authors.forename: B M
authors.initials: BM
authors.lastname: Aleman
authors.forename: A A
authors.initials: AA
authors.lastname: Hart
authors.forename: F A
authors.initials: FA
authors.lastname: Zoetmulder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000528:radiation effects / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology; D016016:Proportional Hazards Models; D011832:Radiation Injuries / Q000209:etiology / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects; D012044:Regression Analysis; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative / Q000379:methods; D013997:Time Factors