Functional limitation of recruitable collaterals in human subjects--ST segment deviation on intracoronary electrocardiogram during transient coronary occlusion induced by balloon inflation.
Three patients showed ST elevation on precordial electrocardiogram and ST depression on intracoronary electrocardiogram during angioplasty of the left anterior descending coronary arteries (LAD). While none of the patients had spontaneously visible collaterals, all showed transient recruitable collaterals to the LAD. No evident collaterals into the diagonal branches were observed. Possibly, if the intracoronary electrocardiogram represents the potential changes of the epicardial surface in the vicinity of the guidewire tip, then endocardial ischemia may have developed even though epicardial ischemia was not observed, due to relatively sufficient blood flow through the recruitable collaterals to the LAD. ST elevation on the precordial electrocardiogram may have represented epicardial and endocardial ischemia of the diagonal branches, where the recruitable collaterals could not protect against transmural ischemia. These phenomena suggests that the recruitable collaterals are functionally limited during acute coronary occlusion, even though the collaterals are well developed.
Yoshio
H
H
Second Department of Internal Medicine, Kanazawa University School of Medicine, Japan.
Shimizu
M
M
Takeda
R
R
Murakami
T
T
Mifune
J
J
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D003097:Collateral Circulation; D003326:Coronary Circulation; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged