title: Multifocal giant cell glioblastoma: case report.
abstract: Glioblastoma multiforme (GM) of the cerebellum is a rare tumour. A variant of GM, a multifocal giant cell glioblastoma, initially presenting in the cerebellum, has not previously been reported. A giant cell glioblastoma occurring in a 46-year-old man who presented initially with a cerebellar tumour is described. One month after excision of the tumour, the patient had a grand mal seizure. Computed tomography (CT) showed a low-density lesion in the left temporal lobe. Four months later he developed dysphasia and right-sided hemiparesis. Repeat CT scan revealed a large temporal lobe tumour which was excised, and histologically found to be a giant-cell glioblastoma with histopathological similarities to the original cerebellar tumour. The clinical course, computed tomographic and pathological features of this tumour are described and discussed.
authors.affiliation: Royal Preston Hospital, Fulwood, Preston, United Kingdom.
authors.forename: H C
authors.initials: HC
authors.lastname: Parekh
authors.forename: R R
authors.initials: RR
authors.lastname: Sharma
authors.forename: S S
authors.initials: SS
authors.lastname: Prabhu
authors.forename: A J
authors.initials: AJ
authors.lastname: Keogh
authors.forename: P J
authors.initials: PJ
authors.lastname: Lynch
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology; D011379:Prognosis; D011859:Radiography