title: R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. II. Physico-chemical properties and structure determination.
abstract: R1128 A, B, C and D, new non-steroidal estrogen-receptor antagonists, were isolated from the cultured broth of Streptomyces sp. No. 1128. Their structures were elucidated to be 1,3,6-trihydroxy-8-alkylanthraquinones on the basis of their physico-chemical properties and spectroscopic data.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hori
authors.forename: S
authors.initials: S
authors.lastname: Takase
authors.forename: N
authors.initials: N
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: M
authors.initials: M
authors.lastname: Okuhara
authors.forename: M
authors.initials: M
authors.lastname: Kohsaka
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; C082781:1,3,6-trihydroxy-8-n-propylanthraquinone; C082782:1,3,6-trihydroxy-8-n-butylanthraquinone; C082783:1,3,6-trihydroxy-8-(3-methylbutyl)anthraquinone; C082784:1,3,6-trihydroxy-8-n-pentylanthraquinone