Unbalanced translocation (1;7) and inversion 16 in a patient with acute myelocytic leukemia.
Pericentric inversion of chromosome 16 has been delineated as a characteristic chromosome abnormality of acute myelomonocytic leukemia with abnormal eosinophils and a favorable prognosis. By contrast, unbalanced translocation (1;7) has been reported as frequently associated with therapy-related leukemia, and patients with this karyotypic abnormality are susceptible to severe infections which lead to a poor prognosis. Here we report the first case of acute myelocytic leukemia in which the complexed chromosomal aberrations of der(7)t(1;7)(cen;cen) and inv(16) were found simultaneously in the patient's leukemia cells. Eosinocytosis has not been observed so far, but life-threatening pneumonia developed during the remission induction therapy.
Tasaka
T
T
First Department of Internal Medicine, Kagawa Medical School, Japan.
Nagai
M
M
Bando
S
S
Sayo
Y
Y
Murata
M
M
Sasaki
K
K
Ikeda
K
K
Takahara
J
J
D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic