Effects of serine protease inhibitor FOY-305 and heparin on the growth of squamous cell carcinoma.
Effects of serine proteinase inhibitor FOY-305 and heparin on autochthonous skin carcinoma were examined using ddY female mice with single tumor induced by methylcholanthrene. FOY-305 given intraperitoneally for 9 consecutive weeks inhibited the growth of the pre-existing dermal tumors. Heparin alone was equally therapeutically effective. However, heparin induced severe mucocutaneous bleeding of the gastrointestinal mucosa. In contrast, the combined administration of FOY-305 and heparin suppressed tumor growth without any visible side effects. There was a significant increase in well differentiated cancer cells in mice treated with FOY-305 and heparin in combination, suggesting that co-administration of FOY-305 and heparin may be useful for the treatment of squamous cell carcinoma.
Ohkoshi
M
M
Department of Oral Surgery, Faculty of Medicine, University of Tokyo, Japan.
Akagawa
T
T
Nakajima
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D004952:Esters; D005260:Female; D016670:Gabexate / Q000031:analogs & derivatives*; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D006493:Heparin / Q000494:pharmacology* / Q000633:toxicity; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013997:Time Factors
D004952:Esters; D006146:Guanidines; D015842:Serine Proteinase Inhibitors; C034532:camostat; D016670:Gabexate; D008748:Methylcholanthrene; D006493:Heparin