Neuropsychological and neurophysiological assessment of the central effects of interleukin-2 administration.
Neuropsychiatric disturbances may occur following interleukin-2 (IL2) administration. We studied the effects of IL2 infusion on cerebral functions in 7 patients with neuropsychological tests and event-related evoked potentials (P300). We observed a failure in the cognitive performances, an increase in latency, and a decrease in amplitude of P300. These effects followed IL2 administration and were reversible.
Caraceni
A
A
Pain Therapy and Palliative Care Division, National Cancer Institute of Milan, Italy.
Martini
C
C
Belli
F
F
Mascheroni
L
L
Rivoltini
L
L
Arienti
F
F
Cascinelli
N
N
D000328:Adult; D003072:Cognition Disorders / Q000139:chemically induced*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D008545:Melanoma / Q000503:physiopathology / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects; D011994:Recombinant Proteins / Q000009:adverse effects
D007376:Interleukin-2; D011994:Recombinant Proteins