title: Granulation tissue polyposis associated with carcinoid tumours of the small intestine.
abstract: We report two patients with ileal carcinoid tumours which were associated with polyps due to mucosal granulation tissue proliferation. In both cases the tumours had extensively infiltrated the small bowel wall and mesentery, and one had hepatic metastases. The mucosal surface of each specimen showed numerous, pale brown, sessile polyps which were restricted to the intestinal segment involved by carcinoid tumour, although not always closely related to neoplastic cells. The polyps were formed by the proliferation of capillaries, smooth muscle cells and myofibroblasts as demonstrated by immunohistochemistry and electronmicroscopy.
authors.affiliation: Department of Histopathology, Royal Devon and Exeter Hospital, Liverpool, UK.
authors.forename: R O
authors.initials: RO
authors.lastname: Allibone
authors.forename: J
authors.initials: J
authors.lastname: Hoffman
authors.forename: J R
authors.initials: JR
authors.lastname: Gosney
authors.forename: T R
authors.initials: TR
authors.lastname: Helliwell
mesh_terms: D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology* / Q000601:surgery; D005260:Female; D006097:Granulation Tissue / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology* / Q000601:surgery; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D007417:Intestinal Polyps / Q000473:pathology* / Q000601:surgery; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery