Antiproliferative action of the steroid RU486 in cultured human lymphoma cells.
The antiproliferative properties of the synthetic steroid RU486 on the human lymphoma cell line Daudi are described. In suspension cultures, RU486 (10 microM) caused a time dose and cell density dependent reduction of cell proliferation. This effect was reversed within 48 h of withdrawal of RU486 from the growth medium. High concentrations of foetal calf serum can mask the inhibitory effect. In semi-solid cultures RU486 also impaired cell proliferation. Thus RU486 was able to suppress in this tumor cell line the expression of some properties frequently associated with the transformed status of the cells.
Schuster
C
C
Unité Propre de Recherche No. 9002 du CNRS, Strasbourg, France.
Chasserot-Golaz
S
S
Beck
G
G
D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D006801:Humans; D008223:Lymphoma; D015735:Mifepristone / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D015735:Mifepristone