title: Protein-losing enteropathy and hypoalbuminemia in AIDS.
abstract: OBJECTIVE
  To assess the contribution of protein-losing enteropathy to AIDS-associated hypoalbuminemia.
  
  
  METHODS
  Prospective assessment of patients with AIDS.
  
  
  METHODS
  An urban county hospital (Los Angeles & University of Southern California Medical Center. USA).
  
  
  METHODS
  Four groups of patients with AIDS were studied: (1) patients with normal serum albumin (> or = 3.9 g/dl) and normal bowel habits; (2) patients with normal serum albumin and diarrhea (> or = four loose or watery stools per day for > or = 2 weeks); (3) patients with hypoalbuminemia (< or = 3.0 g/dl) and normal bowel habits; and (4) patients with hypoalbuminemia and diarrhea.
  
  
  METHODS
  Fecal alpha 1-antitrypsin concentration was used as a measure of protein loss in the gut.
  
  
  RESULTS
  Patients with hypoalbuminemia had a significantly higher mean fecal alpha 1-antitrypsin concentration than those with normal albumin (10.8 +/- 3.0 mg/g dry stool versus 2.4 +/- 0.4 mg/g dry stool; P < or = 0.001). Although mean fecal alpha 1-antitrypsin concentrations were similar in patients with and without diarrhea in the normal albumin group, patients with hypoalbuminemia and diarrhea had significantly higher levels of fecal alpha 1-antitrypsin than those with hypoalbuminemia and normal bowel habits (17.3 +/- 5.8 mg/g dry stool versus 4.6 +/- 1.0 mg/g dry stool; P = 0.009). Twelve out of 36 (33%) patients with normal albumin had elevation of fecal alpha 1-antitrypsin compared with 33 (70%) of 47 patients with hypoalbuminemia (P < or = 0.001). Linear regression analysis showed a significant negative correlation between serum albumin and fecal alpha 1-antitrypsin concentration (r = -0.38; P < or = 0.001). Fecal alpha 1-antitrypsin was significantly higher in patients with mucosal disease visualized at upper endoscopy or flexible sigmoidoscopy than in those without gross abnormalities (13.5 +/- 5.8 mg/g dry stool versus 2.4 +/- 0.7 mg/g dry stool; P = 0.005).
  
  
  CONCLUSIONS
  Protein-losing enteropathy is common in patients with AIDS and may contribute to the development of hypoalbuminemia in these patients.
authors.affiliation: Division of Gastroenterology, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: L
authors.initials: L
authors.lastname: Laine
authors.forename: F
authors.initials: F
authors.lastname: Garcia
authors.forename: K
authors.initials: K
authors.lastname: McGilligan
authors.forename: A
authors.initials: A
authors.lastname: Malinko
authors.forename: F R
authors.initials: FR
authors.lastname: Sinatra
authors.forename: D W
authors.initials: DW
authors.lastname: Thomas
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000150:complications; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications*; D000328:Adult; D003967:Diarrhea / Q000097:blood / Q000150:complications; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011504:Protein-Losing Enteropathies / Q000097:blood / Q000150:complications*; D012044:Regression Analysis; D012514:Sarcoma, Kaposi / Q000150:complications; D012709:Serum Albumin / Q000172:deficiency*; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D000515:alpha 1-Antitrypsin