SHIN, a low frequency red cell antigen, found in two Japanese blood donors.
A low frequency red cell antigen, SHIN, was detected in two Japanese blood donors. Red cells of the first propositus reacted, in pretransfusion tests, with the serum of a previously untransfused male patient. The second propositus was disclosed when anti-SHIN was used to screen red cells from 3,000 random blood donors in Tokyo: a frequency of 0.03% in this population. Family studies showed SHIN to be inherited as an autosomal dominant character and not to be part of the MNS, FY, JK or P1 blood group systems. Anti-SHIN is not a common antibody in normal sera but was found in about 10% of multispecific sera used in investigation of low frequency antigens.
Nakajima
H
H
Department of Forensic Medicine, Tokyo Medical and Dental University, Japan.
Satoh
H
H
Komatsu
F
F
Green
C A
CA
Tippett
P
P
Lubenko
A
A
D044466:Asian People / Q000235:genetics; D001782:Blood Donors; D001789:Blood Group Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D016130:Immunophenotyping; D007564:Japan; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D001789:Blood Group Antigens