Study of the HLA-DP beta 1 locus by the polymerase chain reaction technique in patients with Hodgkin's disease.
BACKGROUND
A number of reports have studied associations between Hodgkin's disease and HLA. Some of them established correlation between several antigens and Hodgkin's disease, and others found no correlations.


METHODS
The HLA DP locus was determined by the polymerase chain reaction method in 31 Hodgkin's disease patients and 58 healthy controls.


RESULTS
No significant difference between patients and controls was noted.


CONCLUSIONS
Further investigations are needed to confirm the hypothesis of a possible role of the HLA complex as one of the factors involved in Hodgkin's disease.
Pellegris
G
G
Division of Immunohematology, Istituto Nazionale Tumori, Milano, Italy.
Lombardo
C
C
Cantoni
A
A
Devizzi
L
L
Balzarotti
M
M
D001483:Base Sequence; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen