title: Acute renal failure from inhalation of mycotoxins.
abstract: Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending 8 h in a granary which had been closed for several months, a farmer and his wife suffered temporary respiratory distress; 24 h later, the woman developed nonoliguric ARF and biopsy revealed tubulonecrosis which healed in 24 days. Toxic substances were not found, but a strain of A. ochraceus producing ochratoxin was isolated from the wheat.
authors.affiliation: Nephrology and Dialysis Department, Regional Hospital of Siena, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Di Paolo
authors.forename: A
authors.initials: A
authors.lastname: Guarnieri
authors.forename: F
authors.initials: F
authors.lastname: Loi
authors.forename: G
authors.initials: G
authors.lastname: Sacchi
authors.forename: A M
authors.initials: AM
authors.lastname: Mangiarotti
authors.forename: M
authors.initials: M
authors.lastname: Di Paolo
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000280:Administration, Inhalation; D000383:Agriculture; D000818:Animals; D001235:Aspergillus ochraceus / Q000302:isolation & purification; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology; D009793:Ochratoxins / Q000009:adverse effects* / Q000633:toxicity; D011817:Rabbits; D014908:Triticum / Q000382:microbiology
chemical_list: D009793:Ochratoxins