Erythema formation in magnesium-deficient albino rats. A non-invasive model for the screening of anti-inflammatory agents and oral mineral supplements.
The enteral bioavailability of magnesium firmly bound to a fire-proof, inert SiO2-Al2O3 matrix (ground magnesia boats) was studied in magnesium-deficient albino Sprague-Dawley rats, with and without blocking gastric hydrochloric acid secretion with omeprazole. Magnesium was absorbed, although to a small degree, also at anacidity. Pronounced erythema, developing after only some days in hypomagnesemic hypercalcemic rats, are proposed as a non-invasive model for the screening of antiinflammatory substances. Using this model significant protective effects were proven for cromoglycate, polyenthylene glycol 400, and omeprazole; the latter, however, seems more likely to act via a magnesium-sparing mechanism.
Classen
C U
CU
Department of Pharmacology and Toxicology of Nutrition, University of Hohenheim, Fed. Rep. of Germany.
Abele
C
C
Schimatschek
H F
HF
Friedberg
K D
KD
Classen
H G
HG
Haubold
W
W
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001682:Biological Availability; D004205:Cromolyn Sodium / Q000494:pharmacology; D004032:Diet; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004890:Erythema / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D008274:Magnesium / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000150:complications / Q000473:pathology*; D008903:Minerals / Q000627:therapeutic use*; D009853:Omeprazole / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000893:Anti-Inflammatory Agents; D008903:Minerals; D011092:Polyethylene Glycols; D008274:Magnesium; D009853:Omeprazole; D004205:Cromolyn Sodium