Cerebrovascular histopathology after intracarotid infusion of Gelfoam in the rat.
To evaluate the histopathology of Gelfoam on the cerebral vasculature, 42 Sprague-Dawley rats weighing 250 to 300 g received internal carotid artery infusions of 0.3 ml of Gelfoam solution (5 mg/ml) or normal saline (0.9%). The animals were killed at 1 hour, 5 hours, 3 days, 1 week, 2 weeks, and 4 weeks after the infusion. The brains were removed, sectioned, and stained with hematoxylin and eosin. Examination of brain sections revealed Gelfoam emboli lodged primarily in the small leptomeningeal arteries. At 5 hours after infusion, inflammatory cells were noted in the arterial walls with vessel occlusion. Further canalization of vessels was noted at 1 week. At 4 weeks, Gelfoam was not seen in the specimens. This study suggests that Gelfoam acts as an embolic agent in vessels over short periods of time with no residual inflammatory activity postinfusion.
Razack
N
N
Department of Neurosurgery, University of Miami, Florida.
Soloniuk
D S
DS
Perkins
E
E
Chandrasoma
P T
PT
D000818:Animals; D001167:Arteritis / Q000139:chemically induced / Q000473:pathology; D002343:Carotid Artery, Internal; D002536:Cerebral Arteries / Q000473:pathology; D002544:Cerebral Infarction / Q000139:chemically induced / Q000209:etiology; D004621:Embolization, Therapeutic / Q000009:adverse effects; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage*; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D008578:Meninges / Q000098:blood supply; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors