title: Pharmacokinetics and anthelmintic efficacy of febantel in the racing pigeon (Columba livia).
abstract: This paper reports on the pharmacokinetics and the efficacy of febantel against Capillaria obsignata and Ascaridia columbae in the racing pigeon. Febantel was rapidly cleared from the circulation and highly metabolized. The efficacy of febantel against Capillaria and Ascaridia was studied on lightly and heavily infected pigeons. The efficacy against Ascaridia was 100% for the faecal egg count reduction (FECR) as well as for the worm reduction in all treated pigeons. After two treatments with febantel against Capillaria in heavily infected pigeons the FECR amounted to 96.7% and worm reduction was 95%. In order to effectively remove both parasites from the host, repeated treatments with febantel at a short interval could be the treatment of choice.
authors.affiliation: Laboratory of Pharmaceutical Technology, University of Gent, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Baert
authors.forename: S
authors.initials: S
authors.lastname: Van Poucke
authors.forename: H
authors.initials: H
authors.lastname: Vermeersch
authors.forename: J P
authors.initials: JP
authors.lastname: Remon
authors.forename: J
authors.initials: J
authors.lastname: Vercruysse
authors.forename: P
authors.initials: P
authors.lastname: Bastiaensen
authors.forename: P
authors.initials: P
authors.lastname: De Backer
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001198:Ascaridiasis / Q000188:drug therapy / Q000662:veterinary*; D001682:Biological Availability; D001715:Bird Diseases / Q000188:drug therapy*; D002195:Capillaria; D010856:Columbidae / Q000378:metabolism*; D017189:Enoplida Infections / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006146:Guanidines / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male
chemical_list: D000871:Anthelmintics; D006146:Guanidines; C017309:febantel