Influence of dietary lipids on glucuronidation and sulfation of phenol and its para substituent in the rat.
Rats were fed corn oil-free or corn oil-containing diets for 4 weeks to determine their effect on the competition between glucuronidation and sulfation in phenol and its para substituents. The activities of uridine diphosphate-glucuronyltransferase (UDPGT) on chemicals were enhanced with a 12% corn oil diet, whereas sulfotransferase activity showed no significant change. Following the intravenous injection of p-ethylphenol and p-tert-butylphenol, an increase of glucuronide and a decrease of sulfate were observed in the rats fed the corn oil diet. In contrast, no significant changes were observed in phenol and p-phenylphenol. These results are discussed in association with van der Waals volume (Vw) of substituent and phospholipid dependence of UDPGT.
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Daiichi Pure Chemicals Co., Ltd., Ibaraki, Japan.
D000818:Animals; D002855:Chromatography, Thin Layer; D003314:Corn Oil / Q000494:pharmacology; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D005965:Glucuronates / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010636:Phenols / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence; D013431:Sulfates / Q000378:metabolism*; D015238:Sulfotransferases / Q000378:metabolism
D004041:Dietary Fats; D005965:Glucuronates; D010636:Phenols; D010743:Phospholipids; D013431:Sulfates; D003314:Corn Oil; D014453:Glucuronosyltransferase; D015238:Sulfotransferases