title: Common swine leucocyte antigen (SLA) haplotypes in NIH and Sinclair miniature swine have similar effects on the expression of an inherited melanoma.
abstract: Mixed lymphocyte culture and serological typing of NIH and Sinclair miniature swine indicate that the two herds share a common SLA haplotype. NIH haplotype a (International Haplotype H10) appears identical to Sinclair haplotype B, which has significant effects on the penetrance of Sinclair swine cutaneous malignant melanoma (SSCM). Offspring of crosses between melanoma-bearing Sinclair swine homozygous for the B haplotype and non-melanoma NIH aa swine have tumour incidence identical to Sinclair melanoma BB x Sinclair non-melanoma BB offspring. Our results provide further support for the involvement of the swine leucocyte antigen (SLA) complex in the inheritance of SSCM, and identify a new source of non-tumour animals that have all of the genes for SSCM except those at the tumour-initiator locus.
authors.affiliation: Department of Genetics, University of Illinois, Chicago 60612.
authors.forename: R G
authors.initials: RG
authors.lastname: Tissot
authors.forename: C W
authors.initials: CW
authors.lastname: Beattie
authors.forename: M S
authors.initials: MS
authors.lastname: Amoss
authors.forename: J D
authors.initials: JD
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Schumacher
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006239:Haplotypes; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000662:veterinary*; D012878:Skin Neoplasms / Q000235:genetics / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000235:genetics*; D013556:Swine, Miniature / Q000235:genetics* / Q000276:immunology
chemical_list: D006649:Histocompatibility Antigens