title: Diabetes and its complications may be caused by inadequate circulation. A new concept.
abstract: Students of diabetes have noted that the so-called vascular complications of the disease appear with little or no consistency. Uncontrolled patients may have no vascular problems. Contrarywise obsessive compulsive individuals who follow every dietary regimen perfectly and take their prescriptions faithfully may have horrendous vascular difficulties. These experiences brought me to the conclusion that the 'complications' were really a component of the disease rather than the result of it. In an effort to find a unified concept of the disease it seemed reasonable to conclude that inadequate circulation to the islets may be a cause of the chemical constellation that we call diabetes. Vascular pathology may appear haphazardly in various arteries. Thus some will develop cerebrovascular disease, others coronary manifestations while still other patients will experience peripheral vascular symptoms. Is it not possible that defective circulation to the pancreas might be an aetiological factor in the development of diabetes? These observations lend credence to the concept that arterial pathology may actually precede the appearance of clinical diabetes.
authors.forename: H
authors.initials: H
authors.lastname: Berger
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000209:etiology*; D003925:Diabetic Angiopathies / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007515:Islets of Langerhans / Q000098:blood supply; D008954:Models, Biological
chemical_list: D001786:Blood Glucose