A simple and efficacious criterion based on serum LH levels to time hCG administration for human in vitro fertilization.
OBJECTIVE
To test the efficacy of a simple criterion--LH level--for administration of hCG in an IVF program.


METHODS
Prospective, with retrospective analysis of other criteria for hCG administration.


METHODS
University hospital IVF program.


METHODS
Eighty-four patients, in 110 cycles, were given 150-300 IU at 10-11 A.M. daily beginning on day 3 of the cycle. Serum LH measured daily 8:30-9:30 A.M., hCG administered on night of day LH level first exceeded J, defined as minimum value + (day 3 value-minimum) x 1/3.


METHODS
Pregnancy (after IVF + ET); serum concentrations of estradiol and LH.


RESULTS
Total and ongoing pregnancy per cycle: 35% and 27% respectively. If hCG is administered one day early or late by the J criterion, the pregnancy rate is reduced.


CONCLUSIONS
Pregnancies occurred over wide follicle diameter (14-21 mm) and estradiol level (229-2,050 pg/mL) ranges. LH is recommended for timing hCG administration.
Jinno
M
M
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
Sugimura
K
K
Kobayashi
T
T
Nozawa
S
S
Itoh
S
S
Takeshita
E
E
Kikuchi
H
H
D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007986:Luteinizing Hormone / Q000097:blood*; D008597:Menstrual Cycle / Q000097:blood; D006080:Ovarian Follicle / Q000033:anatomy & histology; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin; D004958:Estradiol; D007986:Luteinizing Hormone