Radiosensitivity, blood perfusion and tumour oxygenation after perflubron emulsion injection.
The effect of 90% and/or 100% w/v perflubron (perfluorooctyl bromide (PFOB); Alliance Pharmaceutical Corp.) emulsions on radiosensitivity, tumour relative perfusion and oxygenation was studied using EMT6 tumours in nude mice. Perflubron (2-15 ml/kg) emulsion was injected. The mice inhaled carbogen for 30 min and 60 min prior to irradiation. The radiosensitizing effect of the 90% w/v emulsion was maximal at 4 ml/kg. The tumour relative perfusion diminished after injection of both 100% and 90% w/v emulsions in carbogen-breathing mice at a dose of 15 ml/kg. This drop could explain the lack of efficiency of these treatments at this high concentration. Lastly, tumour oxygenation was increased after administration of perflubron emulsion plus carbogen.
Vitu-Loas
L
L
Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.
Thomas
C
C
Chavaudra
N
N
Guichard
M
M
D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000494:pharmacology; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D006842:Hydrocarbons, Brominated; D007267:Injections; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000378:metabolism* / Q000532:radiotherapy; D051379:Mice; D008819:Mice, Nude; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; C011700:carbogen; C003072:perflubron; D010100:Oxygen