High-dose cytarabine neurotoxicity: MR findings during the acute phase.
The authors report an acute cerebral and cerebellar syndrome in a patient treated with high-dose cytarabine. Diffuse high-intensity lesions in the central white matter on T2-weighted MR completely reversed with resolution of the clinical syndrome. Although the autopsy revealed cerebellar injury, the cerebral cortex was grossly and microscopically normal, consistent with a reversible process.
Vaughn
D J
DJ
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.
Jarvik
J G
JG
Hackney
D
D
Peters
S
S
Stadtmauer
E A
EA
D000208:Acute Disease; D000328:Adult; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D016879:Salvage Therapy
D003561:Cytarabine