Malignant osteopetrosis treated with high doses of 1 alpha-hydroxyvitamin D3 and interferon gamma.
A male infant with malignant osteopetrosis was treated with high doses of 1 alpha-hydroxyvitamin D3 and interferon gamma. Therapy with 1 alpha-hydroxyvitamin D3 increased the serum calcium level despite the markedly elevated serum level of 1 alpha, 25-dihydroxyvitamin D before treatment. Recombinant human interferon gamma increased neither the bone mineral nor matrix turnover, and was not tolerated because of bone marrow suppression.
Kubo
T
T
Department of Pediatrics, Okayama University Medical School, Japan.
Tanaka
H
H
Ono
H
H
Moriwake
T
T
Kanzaki
S
S
Seino
Y
Y
D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology / Q000627:therapeutic use*; D007223:Infant; D007371:Interferon-gamma / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010022:Osteopetrosis / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D011994:Recombinant Proteins
D006887:Hydroxycholecalciferols; D011994:Recombinant Proteins; D007371:Interferon-gamma; C008088:alfacalcidol