A toxin that recognizes muscarinic acetylcholine receptors. Preparation and characterization of crystals suitable for structural analysis.
Muscarinic toxin 2 from Dendroaspis angusticeps has been crystallized by vapour diffusion, in sodium acetate using sodium thiocyanate as a precipitant. Trigonal crystals (space group P3(1)21 or P3(2)21) have been obtained. The unit cell parameters are a = b = 64.2 A and c = 37.1 A. The presence of one molecule per asymmetric unit is estimated.
Ménez
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Département d'Ingenierie et d'Etudes des Proteines, Gif-sur-Yvette, France.
Ducruix
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A
D000818:Animals; D003460:Crystallization; D004546:Elapid Venoms / Q000737:chemistry*; D018727:Muscarinic Antagonists; D009498:Neurotoxins / Q000737:chemistry*; D011487:Protein Conformation; D030162:Reptilian Proteins; D012911:Snakes
D004546:Elapid Venoms; D018727:Muscarinic Antagonists; D009498:Neurotoxins; D030162:Reptilian Proteins; C070124:muscarinic toxin 2