title: Autologous bone marrow transplantation. A review of the principles and complications.
abstract: High-dose chemotherapy and autologous bone marrow transplantation (ABMT) is now used routinely in an attempt to cure patients with poor-prognosis malignant diseases. This aggressive and intensive treatment requires a highly trained health-care team. Nurses specializing in the care of these patients are essential to maintain patient well-being and ensure a good outcome. High-dose therapy leads to myelosuppression and tissue damage, and the resultant infections, bleeding, and organ toxicities are frequently either unusual or more severe than those seen with conventional-dose antineoplastic therapies. Organ toxicities can affect both short-term and long-term functional status. Disabling or even fatal consequences of treatment can occur during the transplant or months or years later. A specialized knowledge base and an understanding of the way this therapy affects the patient is required not only for the acute inpatient period, but also for the long term. A team approach to these complex patients with a central role for the nurse clinician will lead to optimal patient care.
authors.affiliation: Bone Marrow Transplant Program, Hospital of the University of Pennsylvania, Philadelphia.
authors.forename: E M
authors.initials: EM
authors.lastname: Lin
authors.forename: D K
authors.initials: DK
authors.lastname: Tierney
authors.forename: E A
authors.initials: EA
authors.lastname: Stadtmauer
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology / Q000379:methods / Q000451:nursing / Q000523:psychology; D006801:Humans; D009720:Nurse Clinicians; D010348:Patient Care Team; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000276:immunology / Q000379:methods / Q000451:nursing / Q000523:psychology