Ranitidine-induced acute interstitial nephritis with epithelial cell foot process fusion.
Although acute interstitial nephritis has been well described with the histamine H2-receptor antagonist cimetidine, we found only one previous case report of ranitidine-induced interstitial nephritis in the literature. We describe an additional patient who developed acute interstitial nephritis after taking ranitidine. Electron microscopy showed focal fusion of the epithelial cell foot processes that was not described in the previous report of ranitidine-induced interstitial nephritis.
Gaughan
W J
WJ
Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
Sheth
V R
VR
Francos
G C
GC
Michael
H J
HJ
Burke
J F
JF
D000208:Acute Disease; D000368:Aged; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008561:Membrane Fusion; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology*; D011899:Ranitidine / Q000009:adverse effects*
D011899:Ranitidine