title: Cisplatin-based chemotherapy in recurrent or high risk ovarian granulosa-cell tumor patients.
abstract: Nine chemotherapy-naive women with recurrent (2 patients) or high risk factors (bilateral or extraovarian spread, poorly-differentiated tumor, age > or = 40 years at diagnosis, residual disease after surgery) granulosa-cell tumors were treated with cisplatin, cyclophosphamide with or without doxorubicin (PAC, PC) or cisplatin, etoposide and bleamycin (PVP-16B). Toxicity was acceptable and the most frequently encountered adverse reactions were WHO grade 3 gastrointestinal toxicity in 77% of patients, and grade 3 myelosuppression in 22% of cases. Clinical complete response was achieved in the 2 patients with recurrent disease. Five patients underwent second look surgery which documented: complete response in 3 patients, partial response in 1 patient and progressive disease in 1 case. Median survival was 85 months (range 14-103). Cisplatin-based cytotoxic regimens may be of benefit in the treatment of recurrent or high risk granulosa-cell tumors.
authors.affiliation: Istituto Nazionale per la Ricerca sul Cancro, Genova.
authors.forename: S
authors.initials: S
authors.lastname: Chiara
authors.forename: L
authors.initials: L
authors.lastname: Merlini
authors.forename: E
authors.initials: E
authors.lastname: Campora
authors.forename: M
authors.initials: M
authors.lastname: Bruzzone
authors.forename: S
authors.initials: S
authors.lastname: Giudici
authors.forename: R
authors.initials: R
authors.lastname: Rosso
authors.forename: N
authors.initials: N
authors.lastname: Ragni
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006106:Granulosa Cell Tumor / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin