title: How tautological are interspecies correlations of carcinogenic potencies?
abstract: Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.
authors.affiliation: Statistics Department, University of California, Berkeley 94720.
authors.forename: D A
authors.initials: DA
authors.lastname: Freedman
authors.forename: L S
authors.initials: LS
authors.lastname: Gold
authors.forename: T H
authors.initials: TH
authors.lastname: Slone
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology*; D051381:Rats; D012107:Research Design; D013045:Species Specificity; D013223:Statistics as Topic