title: Effect of zinc therapy on natural killer cell activity in inflammatory bowel disease.
abstract: Disturbances in zinc metabolism have been documented in patients with inflammatory bowel disease. In this study we evaluated the effect of in vivo treatment with zinc on the in vitro natural killer cell activity in thirteen inflammatory bowel disease patients, with stable disease and mild-moderate disease activity, in a double-blind randomized cross-over trial. The results of our study show a long-lasting effect of in vivo zinc administration, which decreased peripheral blood natural killer cell activity in inflammatory bowel disease.
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital Leiden, The Netherlands.
authors.forename: Y
authors.initials: Y
authors.lastname: Van de Wal
authors.forename: A
authors.initials: A
authors.lastname: Van der Sluys Veer
authors.forename: H W
authors.initials: HW
authors.lastname: Verspaget
authors.forename: T P
authors.initials: TP
authors.lastname: Mulder
authors.forename: G
authors.initials: G
authors.lastname: Griffioen
authors.forename: E A
authors.initials: EA
authors.lastname: Van Tol
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
mesh_terms: D000328:Adult; D002470:Cell Survival / Q000187:drug effects; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000276:immunology; D003424:Crohn Disease / Q000188:drug therapy / Q000276:immunology; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology*; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D015032:Zinc / Q000097:blood / Q000627:therapeutic use*
chemical_list: D015032:Zinc