title: Lignified materials as medicinal resources. VI. Anti-HIV activity of dehydrogenation polymer of p-coumaric acid, a synthetic lignin, in a quasi-in-vivo assay system as an intermediary step to clinical trials.
abstract: After the dehydrogenation polymer of p-coumaric acid, a synthetic lignin, was intravenously injected into mice, the serum was collected immediately, 15 min, 1 h, 5 h, and 24 h after the injection. The serum thus obtained was added to the assay medium containing MT-4 cells infected with HTLV-IIIB (an HIV-1 strain). Inhibition of the cytopathogenicity of HIV by these serum preparations was assayed by the MTT method. The result revealed that lignins could be a promising class of anti-HIV agents with an unidentified unique mode of action.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Naoe
authors.forename: Y
authors.initials: Y
authors.lastname: Kawazoe
authors.forename: H
authors.initials: H
authors.lastname: Sakagami
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Yamamoto
mesh_terms: D000998:Antiviral Agents / Q000097:blood / Q000494:pharmacology*; D002478:Cells, Cultured; D003373:Coumaric Acids / Q000097:blood / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D011108:Polymers / Q000494:pharmacology*; D011422:Propionates
chemical_list: D000998:Antiviral Agents; D003373:Coumaric Acids; D011108:Polymers; D011422:Propionates; C495469:p-coumaric acid