Aetiology of acute sporadic non-A, non-B viral hepatitis in India.
Non-A, non-B (NANB) hepatitis viruses are now classified as hepatitis E (enterically transmitted) and hepatitis C (parenterally transmitted). India experiences a large number of epidemics of the enteric disease every year. In addition, about 70% of the sporadic cases among adults are also due to NANB hepatitis. With the availability of an immunoblot assay for the detection of anti-HEV-IgM and the polymerase chain reaction (PCR) for the detection of HCV-RNA, serum samples from epidemic and sporadic NANB patients were screened for these markers. We found that a large number of cases from the epidemics were HEV, though a few remained undiagnosed, while of the sporadic cases only a few could be diagnosed as HCV or HEV; a large proportion remained undiagnosed.
Arankalle
V A
VA
National Institute of Virology, Pune India.
Chobe
L P
LP
Jha
J
J
Chadha
M S
MS
Banerjee
K
K
Favorov
M O
MO
Kalinina
T
T
Fields
H
H
D000208:Acute Disease; D001483:Base Sequence; D004196:Disease Outbreaks; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000175:diagnosis / Q000453:epidemiology*; D016751:Hepatitis E / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015151:Immunoblotting; D007075:Immunoglobulin M / Q000097:blood*; D007194:India / Q000453:epidemiology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012367:RNA, Viral / Q000097:blood*
D006508:Hepatitis Antibodies; D006514:Hepatitis B Surface Antigens; D007075:Immunoglobulin M; D012367:RNA, Viral