title: Simultaneous recording of blood volume shifts in different vascular beds in man by a versatile scintigraphic method.
abstract: A device was developed to record the blood volume changes occurring in the lung and calf during postural changes, physical exercise, and the Valsalva maneuver in man. The changes in regional counting rates from the right middle lung and the calf mirrored the well-known changes in venous return that are expected to occur in response to the above-mentioned external stimuli. Thus a sustained decrease in lung blood volume was noted on assumption of the erect posture as well as during the forced expiration of the Valsalva maneuver. In addition a rapid increase and a sharp decrease in lung blood volume took place at the very onset and at the very end of walking, respectively. The calf blood volume declined immediately at the onset of walking, increased slightly in the ensuing two minutes, and returned to baseline quickly at the termination of walking. The authors' method enables real-time equilibrium blood pool scintigraphy to be recorded continuously and simultaneously from different districts over sustained periods of time irrespective of the posture and the physical activity performed by the patient. Their method might improve knowledge of the systemic circulatory responses to selective physiologic and therapeutic interventions in health and disease.
authors.affiliation: Centro di Fisiologia Clinica e Ipertensione, Ospedale Maggiore, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Baccelli
authors.forename: S
authors.initials: S
authors.lastname: Terrani
authors.forename: P
authors.initials: P
authors.lastname: Pacenti
authors.forename: E
authors.initials: E
authors.lastname: Omboni
authors.forename: M
authors.initials: M
authors.lastname: Bergonzi
authors.forename: P
authors.initials: P
authors.lastname: Reggiani
authors.forename: F
authors.initials: F
authors.lastname: Sardella
authors.forename: M
authors.initials: M
authors.lastname: Catalano
authors.forename: R
authors.initials: R
authors.lastname: Bianchi
mesh_terms: D001810:Blood Volume / Q000502:physiology*; D001811:Blood Volume Determination / Q000295:instrumentation; D004867:Equipment Design; D015637:Gated Blood-Pool Imaging / Q000295:instrumentation / Q000379:methods*; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging; D008168:Lung / Q000098:blood supply* / Q000000981:diagnostic imaging; D011187:Posture / Q000502:physiology; D013667:Technetium; D014636:Valsalva Maneuver; D016138:Walking / Q000502:physiology
chemical_list: D013667:Technetium