Inhibition of albumin denaturation and anti-inflammatory activity of acetamido [(phenyl-4'-yl)-oxymethyl)]2-(p-substituted phenylamino)-1,2,4-triazoles and -1,3,4-thiadiazoles.
Acetamido [(phenyl-4'-yl)-oxymethyl)]-2-(p-substituted-phenylamino)-1,2,4-tr iazoles (4a-4d) and 1,3,4-thiadiazoles (5a-5d) inhibited the thermal denaturation of bovine serum albumin. As protein denaturation is implicated in inflammation, some compounds which showed good inhibition of denaturation were tested in vivo for anti-inflammatory activity by carrageenan induced edema in the rat paw. Although there was no complete correlation, compounds which showed good inhibition of denaturation also showed significant anti-inflammatory activity.
Nargund
L V
LV
Department of Pharmaceutical Chemistry, College of Pharmacy, J.N. Medical College, Belgaum, India.
Redd
G R
GR
Hariprasad
V
V
D000818:Animals; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D011489:Protein Denaturation / Q000187:drug effects; D051381:Rats; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D013830:Thiadiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D014230:Triazoles / Q000494:pharmacology* / Q000627:therapeutic use
D013830:Thiadiazoles; D014230:Triazoles; D012710:Serum Albumin, Bovine