title: Safety and efficacy of human growth hormone treatment in girls with Turner syndrome.
abstract: Six major adverse medical events (AMEs) and 44 minor AMEs were recorded in 6 and 23 patients, respectively, during human growth hormone (GH) treatment of Turner syndrome, equivalent to 118 treatment years. During the first year of GH treatment, there was no change in the SD score (SDS) for systolic or diastolic blood pressure. In a subgroup of 20 patients, there was no change in psychological tests, oral glucose tolerance, glycosylated haemoglobin or serum triglycerides over the first year of GH treatment. The mean total serum cholesterol level fell over this period. The low incidence of adverse medical problems during GH treatment complemented its efficacy. Height velocity in the first year was 7.7 +/- 1.8 cm/year (mean +/- SD) and was correlated with maternal height SDS, though not with paternal height SDS. Some 36% of first-year height velocity SDS could be predicted by the dose of GH and maternal height SDS.
authors.affiliation: Department of Child Health, Manchester University, Royal Manchester Children's Hospital, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Price
authors.forename: P E
authors.initials: PE
authors.lastname: Clayton
authors.forename: E H
authors.initials: EH
authors.lastname: Crowne
authors.forename: C R
authors.initials: CR
authors.lastname: Roberts
mesh_terms: D000293:Adolescent; D001519:Behavior / Q000187:drug effects; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D004688:Encopresis / Q000139:chemically induced / Q000523:psychology; D004775:Enuresis / Q000139:chemically induced / Q000523:psychology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008209:Lymphedema / Q000139:chemically induced; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012044:Regression Analysis; D012640:Seizures / Q000139:chemically induced; D013981:Tic Disorders / Q000139:chemically induced; D014280:Triglycerides / Q000097:blood; D014424:Turner Syndrome / Q000188:drug therapy* / Q000523:psychology
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D013006:Growth Hormone; D011994:Recombinant Proteins; D014280:Triglycerides