title: [The crystalline lens as a model for studying the cellular and molecular mechanisms of differentiation in the adult organism].
abstract: This review summarizes the published and authors own data about characteristics of expression of tissue-specific lens proteins (crystallins) during differentiation of lens epithelial cells into lens fibers in adult mammals, birds, reptiles, and amphibians. Information is analyzed about the presence, synthesis, and localization of different crystallins in lens epithelium and fiber cells of lens cortex and nucleus which correspond to sequential stages of lens cell differentiation. The data available suggest that morphologically similar differentiation of lens epithelial cells into fibers in different classes of vertebrates is accompanied by different programs for activation (and/or increase) of tissue-specific protein synthesis.
authors.forename: V N
authors.initials: VN
authors.lastname: Simirskiĭ
authors.forename: A T
authors.initials: AT
authors.lastname: Mikhaĭlov
authors.forename: K S
authors.initials: KS
authors.lastname: Aleĭnikova
mesh_terms: D000663:Amphibians; D000818:Animals; D001717:Birds; D002454:Cell Differentiation / Q000502:physiology; D003459:Crystallins / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D007908:Lens, Crystalline / Q000166:cytology* / Q000378:metabolism; D008322:Mammals
chemical_list: D003459:Crystallins
vernacular_title: Khrustalik kak model' dlia izucheniia kletochnykh i molekuliarnykh mekhanizmov differentsirovki vo vzroslom organizme.