Effect of garlic on total serum cholesterol. A meta-analysis.
OBJECTIVE
To assess the size and consistency of garlic's effect on total serum cholesterol in persons with cholesterol levels greater than 5.17 mmol/L (200 mg/dL).


METHODS
Clinical trials were identified by a computerized literature search of MEDLINE and by an assessment of the bibliographies of published studies and reviews.


METHODS
Trials were selected if they were randomized and placebo-controlled and if at least 75% of their patients had cholesterol levels greater than 5.17 mmol/L (200 mg/dL). Studies were excluded if they did not provide enough data to compute effect size. Five of 28 studies were selected for review.


METHODS
Details of study design, patient characteristics, interventions, duration of therapy, and cholesterol measurements were extracted by one author and were verified by another.


RESULTS
Study quality was evaluated by multiple reviewers using a closed-ended questionnaire. Patients treated with garlic consistently showed a greater decrease in total cholesterol levels compared with those receiving placebo. Meta-analysis of homogeneous trials estimated a net cholesterol decrease attributable to garlic of 0.59 mmol/L (95% CI, 0.44 to 0.74) (23 mg/dL [CI, 17 to 29]) (P < 0.001).


CONCLUSIONS
Meta-analysis of the controlled trials of garlic to reduce hypercholesterolemia showed a significant reduction in total cholesterol levels. The best available evidence suggests that garlic, in an amount approximating one half to one clove per day, decreased total serum cholesterol levels by about 9% in the groups of patients studied.
Warshafsky
S
S
Department of Medicine, New York Medical College, Valhalla 10595.
Kamer
R S
RS
Sivak
S L
SL
D000284:Administration, Oral; D002784:Cholesterol / Q000097:blood*; D004304:Dosage Forms; D005260:Female; D005737:Garlic; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal; D012107:Research Design; D012680:Sensitivity and Specificity
D004304:Dosage Forms; D002784:Cholesterol