title: Absence of brain antibodies in the sera of relapsing-remitting multiple sclerosis patients is not due to the formation of immune complexes.
abstract: Using an enzyme-linked immunoadsorbent assay, we looked, whether the formation of idiotype-anti-idiotype complexes was responsible for the absence of antibodies in the sera of MS patients. We tested 18 relapsing-remitting and 26 chronic progressive patients versus 44 age- and sex-matched controls. We did not find elevated titres of immune complexes in the sera of the multiple sclerosis patients.
authors.affiliation: Department of Neurology, University of Ulm, Germany.
authors.forename: A E
authors.initials: AE
authors.lastname: Henneberg
authors.forename: U
authors.initials: U
authors.lastname: Elsner
authors.forename: H H
authors.initials: HH
authors.lastname: Kornhuber
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000276:immunology*; D015922:Complement C1q / Q000276:immunology; D015933:Complement C3d / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D015922:Complement C1q; D015933:Complement C3d