Application of X-ray crystallographic methods in the design of purine nucleoside phosphorylase inhibitors.
Ealick
S E
SE
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853.
Babu
Y S
YS
Bugg
C E
CE
Erion
M D
MD
Guida
W G
WG
Montgomery
J A
JA
Secrist
J A
JA
D001665:Binding Sites; D003196:Computer Graphics; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
D004791:Enzyme Inhibitors; D011683:Purine-Nucleoside Phosphorylase