title: Hemostatic study before onset of disseminated intravascular coagulation.
abstract: Early diagnosis is necessary for the treatment of disseminated intravascular coagulation (DIC), but criteria for the stage preceding the diagnosis of DIC (pre-DIC) have not yet been established. To clarify hemostatic abnormalities that occur before the onset of DIC, we performed hemostatic studies in 117 patients within at least a week before the onset of DIC (pre-DIC), in 237 patients with DIC, and in 50 patients without DIC or pre-DIC (non-DIC). Levels of FDP, PT, and fibrinogen, and platelet counts were significantly abnormal after the onset of DIC, but not before. Thrombin-antithrombin III complex (TAT), plasmin-alpha 2 plasmin inhibitor complex (PIC), and FDP-D-dimer levels were significantly higher before the onset of DIC compared to the non-DIC patients. Hemostatic abnormalities were observed within a week before the onset of DIC. Monitoring the plasma levels of TAT, PIC, and FDP-D-dimer might be useful for the diagnosis of a pre-DIC condition.
authors.affiliation: 2nd Department of Internal Medicine, College of Medical Science, Mie University School of Medicine, Tsu-city, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: K
authors.initials: K
authors.lastname: Minamikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Wakita
authors.forename: T
authors.initials: T
authors.lastname: Nakase
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: M
authors.initials: M
authors.lastname: Ohiwa
authors.forename: S
authors.initials: S
authors.lastname: Tamaki
authors.forename: A
authors.initials: A
authors.lastname: Deguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Deguchi
mesh_terms: D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000175:diagnosis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D010447:Peptide Hydrolases / Q000032:analysis; D013997:Time Factors
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases