Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation.
The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.
Kamiyama
T
T
Nippon Roche Research Center, Kanagawa, Japan.
Itezono
Y
Y
Umino
T
T
Satoh
T
T
Nakayama
N
N
Yokose
K
K
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D018942:Macrolides; C082780:tetrafibricin