Chromium and parenteral nutrition in children.
Chromium (Cr) dosage was assayed in i.v. nutrition, serum, and losses of five children on total parenteral nutrition for > or = 4 weeks. The Cr supply (4.7 +/- 1.2 micrograms/kg/day) was above recommended levels (0.5 microgram/kg/day). Serum (18.2 +/- 1.8 micrograms/L) and urine (37.4 +/- 10.5 micrograms/L) were also higher than control values (0.7-0.9 microgram/L and 0.2-0.8 microgram/L, respectively). Serum and urine Cr concentrations displayed a positive correlation. Serum Cr and Fe showed a negative correlation. These results confirm the potential toxicity of Cr previously reported in animals. Cr levels of i.v. nutrition solutes should be checked thoroughly.
Bougle
D
D
Pédiatrie A, CHU Clémenceau, Caen, France.
Bureau
F
F
Deschrevel
G
G
Hecquard
C
C
Neuville
D
D
Drosdowsky
M
M
Duhamel
J F
JF
D002648:Child; D002857:Chromium / Q000008:administration & dosage* / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism; D010288:Parenteral Nutrition
D002857:Chromium; D007501:Iron