Limited sequence divergence of HTLV-I of Indian HAM/TSP patients from a prototype Japanese isolate.
Nucleotide sequences of two HTLV-I proviruses isolated from Indian patients with HAM/TSP were analyzed. The sequence data of the env, pX, and LTR regions showed 98-99% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese ATL patient, indicating that HTLV-I isolates in India and Japan are similar, with minor variations. However, certain small sequences of noncoding regions in the pX and LTR showed differences of 6.1 and 7.2%, respectively, thus the conclusion could vary depending on the regions and length of the sequences used for comparison.
Hashimoto
K
K
Department of Cellular and Molecular Biology, University of Tokyo, Japan.
Lalkaka
J
J
Fujisawa
J
J
Singhal
B S
BS
Machigashira
K
K
Kubota
R
R
Suehara
M
M
Osame
M
M
Yoshida
M
M
D000328:Adult; D001483:Base Sequence; D005260:Female; D005814:Genes, Viral / Q000235:genetics*; D015752:Genes, env / Q000235:genetics; D016355:Genes, pX / Q000235:genetics; D014644:Genetic Variation; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology / Q000235:genetics*; D011533:Proviruses / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid