[Antagonistic effects of cholinergic drugs on xylazine induced sedation].
Xylazine induced sedation in mice was observed as a kind of inhibition of exploratory activity. The reversible cholinesterase inhibitor cui xing ning (0.25-1.0 m.kg-1), the precursor of acetylcholine, choline bromide (100-300 mg.kg-1), and the M-receptor agonist arecoline (1.0-5.0 mg.kg-1) were shown to significantly antagonize xylazine (5.0 mg.kg-1) induced sedation. While cui xing ning (0.25 mg.kg-1) shifted the dose-response curve of xylazine induced sedation to the right, hemicholinum-3 (3 micrograms icv), which inhibits the synthesis of acetylcholine, shifted the dose-response curve to the left. These results suggest that the xylazine induced sedation may be partly due to a reduced central cholinergic function. Cui xing ning may have some value in the treatment of xylazine overdose and antagonize the anesthesia induced by anesthetics combined with xylazine.
Ding
R G
RG
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
Huang
S J
SJ
Yang
J S
JS
D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006426:Hemicholinium 3 / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D014991:Xylazine / Q000037:antagonists & inhibitors*
D002219:Carbamates; D002800:Cholinesterase Inhibitors; D007211:Indoles; C034763:cui xing ning; D014991:Xylazine; D006426:Hemicholinium 3; D001115:Arecoline