[Current contribution of molecular biology in the diagnosis of hepatitis B].
Recent advances in molecular biology had led to a better understanding of the pathology of hepatitis B virus. The polymerase chain reaction technique has shown that the genome of hepatitis B virus is highly variable. Mutations in the pre-core region are associated with HBe Ag negative chronic hepatitis and fulminant hepatitis B; moreover, rare cases of hepatitis due to HBV with mutations within the S gene have been reported in HBV-vaccinated patients. The aim of this paper is to assess the clinical, serological and therapeutic features of hepatitis B variants.
Brenard
R
R
Hépato-gastroentérologie, Hôpital St-Joseph, Gilly.
D016678:Genome; D006509:Hepatitis B / Q000235:genetics* / Q000382:microbiology; D006510:Hepatitis B Antibodies; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D006521:Hepatitis, Chronic / Q000235:genetics; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction
D006510:Hepatitis B Antibodies
Apports récents de la biologie moléculaire dans le diagnostic des hépatites dues au virus B.