Morphine-induced hyperactivity in rats--a rebound effect?
The behavioural nature of the delayed hyperactivity induced by systemic administration of morphine was studied in rats. Different components of motility induced by morphine with or without naloxone or haloperidol at different times were analyzed by observation and quantified by an Opto-Varimex-3 Activity Meter. By this automatic recording system motility was discriminated into horizontal and two different vertical components and the total distance run by each of the rats was quantified by a computer program. Simultaneously the running pattern was recorded by a XY-plotter. By means of these recordings, three subsequent phases of behaviour could be recorded after morphine (15 mg/kg i.p.): 1. a depressed phase (akinesia) lasting 1.5-2 h, followed, 2. by an intermediate phase for 1-1.5 h, still dominated by akinesia but interrupted by sudden bursts of hyperactivity. Finally, 3. a hyperactivity phase lasted for 1.5-2 h, characterized by an equal enhancement of locomotor activity and stereotypy. After 30 mg/kg of morphine the hyperactivity was predominantly characterized by locomotor activity and stereotypy and rearing were less prominent than after the smaller dose. Naloxone (2 mg/kg i.p.) given at the beginning of the hyperactivity phase significantly antagonized rearing but not other motility parameters. However, coadministration of naloxone (2 mg/kg i.p.) simultaneously with morphine (15 mg/kg) clearly antagonized akinesia and completely prevented the development of the delayed hyperactivity. Haloperidol (0.2 mg/kg i.p.) at the beginning of the hyperactivity phase clearly antagonized all of the motility parameters seen during this phase.(ABSTRACT TRUNCATED AT 250 WORDS)
Magnus-Ellenbroek
B
B
Psychiatric Hospital, University of Göttingen, Federal Republic of Germany.
Havemann-Reinecke
U
U
D000818:Animals; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical
D009270:Naloxone; D009020:Morphine; D006220:Haloperidol