[Anti-centriole antibodies and high neuron-specific enolase activity in a patient with Raynaud phenomenon, cerebrovascular lesions, and ischemic finger necrosis--a functional relationship?].
In a 49-year-old patient with acute thrombangitis obliterans, several vascular risk factors and associated features of collagen vascular disease, we observed anti-centriole autoantibodies and a strongly elevated neuron-specific enolase (NSE). The latter could not be attributed to an underlying malignant or neuroendocrine disease. The recent identification of NSE as a centrosomal protein suggests a causal relationship between anti-centriole autoantibodies and elevated serum NSE levels.
Terreri
T
T
Abteilung Rheumatologie, Medizinische Universitätsklinik Freiburg.
Niederhoff
A
A
Zabel
M
M
Blum
U
U
Peter
H H
HH
D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications*; D002502:Centrioles / Q000276:immunology*; D002561:Cerebrovascular Disorders / Q000150:complications*; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000150:complications; D008875:Middle Aged; D009336:Necrosis; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011928:Raynaud Disease / Q000150:complications*
D001323:Autoantibodies; D010751:Phosphopyruvate Hydratase
Anti-Zentriolen-Antikörper und hohe neuronenspezifische Enolase-Aktivität bei einer Patientin mit Raynaud-Phänomen, zerebrovaskulären Läsionen und ischämischen Fingernekrosen--ein assoziierter Befund?