Ramoplanin susceptibility testing criteria.
Ramoplanin and mupirocin are two antimicrobial agents that may be applied topically. They had similar potencies against susceptible gram-positive cocci, but they differed in their spectra of activity. In plastic microdilution trays, the in vitro activity of ramoplanin was slightly diminished but that activity was restored by the addition of bovine serum albumin (0.02%). Susceptible strains were defined as those for which MICs of ramoplanin were < or = 2.0 micrograms/ml (without bovine serum albumin) and which had > or = 11-mm zones around 60-micrograms ramoplanin disks. Criteria for a resistant category cannot be defined at this time.
Barry
A L
AL
Clinical Microbiology Institute, Tualatin, Oregon 97062.
Pfaller
M A
MA
Fuchs
P C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003470:Culture Media; D047630:Depsipeptides; D004352:Drug Resistance, Microbial; D005069:Evaluation Studies as Topic; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D016712:Mupirocin / Q000494:pharmacology; D010456:Peptides, Cyclic; D012710:Serum Albumin, Bovine
D000900:Anti-Bacterial Agents; D003470:Culture Media; D047630:Depsipeptides; D010456:Peptides, Cyclic; C041438:ramoplanin; D012710:Serum Albumin, Bovine; D016712:Mupirocin