Leukocyte adhesion.
Adhesion of leukocytes is a major event in the induction and effector phases of the immune response, as well as in inflammatory reactions. T-cell activation requires interaction with antigen-presenting cells (APC), B-cell activation needs cognate interaction with T-cells, while cytotoxic T cells strongly bind target cells. Migration of leukocytes into inflammatory areas is mediated by a crucial step of leukocyte binding to endothelial cells followed by trans-endothelial migration. Adhesion molecules mediating these various cell to cell interactions belong to three families, i.e. the immunoglobulin superfamily, integrins and selectins.
Fischer
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INSERM U 132, Hôpital Necker-Enfants Malades, Paris, France.
D000917:Antibody Formation; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000145:classification / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D007962:Leukocytes / Q000502:physiology*
D015815:Cell Adhesion Molecules