Impaired bacterial killing in early obstructive jaundice.
Sprague-Dawley rats were challenged with intraperitoneal injection of 10(7) Streptococcus pneumoniae 10 days after common duct ligation (BDL) or sham celiotomy (SC). Quantitative bacterial cultures were performed on liver, spleen, lung, kidney, and heart blood samples obtained 4 hours after injection. All 13 (100%) BDL animals had positive heart blood cultures, but only 6 of 12 (50%) SC animals remained bacteremic (p < 0.05). Significantly more viable organisms were recovered from lung, liver, spleen, and kidney of BDL animals compared with SC controls. BDL impaired the host's ability to kill this encapsulated gram-positive organism. Viable bacteria remained in all organs studied, which was associated with continuing bacteremia.
Scott-Conner
C E
CE
Department of Surgery, University of Mississippi School of Medicine, Jackson 39216-4505.
Grogan
J B
JB
Scher
K S
KS
Bernstein
J M
JM
Bailey-Berk
C
C
D000818:Animals; D016470:Bacteremia / Q000503:physiopathology*; D002779:Cholestasis / Q000503:physiopathology*; D003250:Constriction; D008297:Male; D010587:Phagocytosis / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013296:Streptococcus pneumoniae