Immediate rearrangements of human sperm chromosomes following in-vivo irradiation.
The short-term effects of radiotherapy on sperm chromosomes was evaluated in two Hodgkin patients. Sperm cytogenetics were analysed by using human-hamster cross-fertilization. Immediately after irradiation, most sperm metaphases from the first patient exhibited multiple rearrangements, whereas in the second one, the incidence of such abnormalities was only slightly increased. Multi-fragmented chromosomes and structural aberrations of the chromatid-type were observed, suggesting a specific immediate response.
Rousseaux
S
S
Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, France.
Sèle
B
B
Cozzi
J
J
Chevret
E
E
D000818:Animals; D002869:Chromosome Aberrations / Q000502:physiology; D006224:Cricetinae; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D015321:Gene Rearrangement / Q000502:physiology*; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics; D011878:Radiotherapy / Q000009:adverse effects; D013091:Spermatogenesis / Q000528:radiation effects; D013094:Spermatozoa / Q000528:radiation effects*; D013997:Time Factors