title: Comparison of ondansetron with customary treatment in the prophylaxis of nausea and emesis induced by non-cisplatin containing chemotherapy.
abstract: One hundred cancer patients receiving non-cisplatin containing chemotherapy were entered in a prospective study in which the efficacy of ondansetron was compared with standard antiemetic treatments in the prophylaxis of nausea and emesis. During the first 24 h, 77% of patients on ondansetron reported complete control of emesis compared with 56% of those on customary treatments (p = 0.03). However, no statistically significant difference was observed between ondansetron and customary treatments in control of delayed emesis on days 2-5. Nor was any statistically significant difference seen between ondansetron and customary treatments in preventing acute or delayed nausea.
authors.affiliation: Department of Radiotherapy, Kuopio University Hospital, Finland.
authors.forename: I T
authors.initials: IT
authors.lastname: Jantunen
authors.forename: M K
authors.initials: MK
authors.lastname: Flander
authors.forename: M I
authors.initials: MI
authors.lastname: Heikkinen
authors.forename: T A
authors.initials: TA
authors.lastname: Kuoppala
authors.forename: L
authors.initials: L
authors.lastname: Teerenhovi
authors.forename: V V
authors.initials: VV
authors.lastname: Kataja
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy; D017294:Ondansetron / Q000627:therapeutic use*; D011446:Prospective Studies; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D017294:Ondansetron; D002945:Cisplatin