title: Anaphylactic reaction to ranitidine.
abstract: Ranitidine is a well-tolerated H2-receptor antagonist with a furan ring as nucleus. Anaphylactic reactions are seldom reported despite the wide use of the drug. We report a patient who presented an anaphylactic reaction with ranitidine (Zantac). The positive skin prick test and oral challenge suggest type I hypersensitivity. Specific IgE determination by RAST technique and histamine release test with ranitidine were negative. The patient did not react to other H2-receptor antagonists or to another furan-derivative (nitrofurantoin).
authors.affiliation: Servicio de Alergia, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Lázaro
authors.forename: J A
authors.initials: JA
authors.lastname: Compaired
authors.forename: B
authors.initials: B
authors.lastname: De La Hoz
authors.forename: J M
authors.initials: JM
authors.lastname: Igea
authors.forename: C
authors.initials: C
authors.lastname: Marcos
authors.forename: I
authors.initials: I
authors.lastname: Dávila
authors.forename: E
authors.initials: E
authors.lastname: Losada
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D011852:Radioallergosorbent Test; D011899:Ranitidine / Q000009:adverse effects*; D012882:Skin Tests
chemical_list: D011899:Ranitidine