title: Intracavernous application of SIN-I in rabbit and man: functional and toxicological results.
abstract: The mode of action of the active metabolite SIN-I of the vasodilator prodrug molsidomine was studied in vitro and in vivo in corpus cavernosum of rabbit and man. SIN-I produces a dose-dependent relaxation of isolated human cavernous smooth muscle strips. In the rabbit, the intracavernous application of SIN-I increased the intracavernous pressure to a full erection (approximately 100 cm H2O). This response was highly reproductible. SIN-I was also injected intracavernously 6 times in five rabbits over 2 weeks; no inflammatory or fibrotic reactions were found on histology. SIN-I may be a reliable drug for the treatment of impotence without side-effects.
authors.affiliation: Urologische Klinik, Medizinischen Hochschule, Hannover, Germany.
authors.forename: M F
authors.initials: MF
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Taher
authors.forename: H
authors.initials: H
authors.lastname: Krah
authors.forename: J
authors.initials: J
authors.lastname: Staubesand
authors.forename: A J
authors.initials: AJ
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Kircher
authors.forename: B
authors.initials: B
authors.lastname: Mayer
authors.forename: U
authors.initials: U
authors.lastname: Jonas
authors.forename: W G
authors.initials: WG
authors.lastname: Forssmann
authors.forename: C G
authors.initials: CG
authors.lastname: Stief
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008981:Molsidomine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000187:drug effects* / Q000473:pathology; D011817:Rabbits; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; C002385:linsidomine; D008981:Molsidomine