[Activation of the fibrinolytic system following subcutaneous administration and inhalation of heparin].
Heparin was administered to 113 patients at risk of thrombosis classified to abdominal surgery either alone (subcutaneously or in inhalation) or in combination with anabolic steroid (nandrolone). No pharmaco-prophylaxis was used in 10 patients. On the day of surgery, heparin activated plasma fibrinolytic activity, prior to an introduction to anesthesia. Measurements of euglobulins clot lysis have shown an increase in endogenous fibrinolytic activity dependent and independent on Hageman's factor and an increase in exogenous fibrinolysis, tested after venous stasis was produced. Heparin had profibrinolytic activity, stimulating plasminogen activators in the blood plasma without the signs of hyperplasminemia. Fibrinolytic system response was the same following subcutaneous injection and heparin inhalations. Administration of heparin combined with anabolic steroid has no additional effect on plasma fibrinolytic activity.
Psuja
P
P
Kliniki Hematologii Instytutu Chorób Wewnetrznych.
Tokarz
A
A
Turowiecka
Z
Z
Sowier
J
J
Zawilska
K
K
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013927:Thrombosis / Q000517:prevention & control
D006493:Heparin
Aktywacja układu fibrynolitycznego po podskórnym i wziewnym podaniu heparyny.