A gene homologous to the reg gene is expressed in the human pancreas.
We have determined the nucleotide sequence of regl a human genomic DNA fragment homologous to the reg gene which is expressed in the exocrine pancreas and regenerating islets. Sequence comparisons of reg and regl suggested similar exon-intron organisation. Based on this assumption, specific oligonucleotides for regl exons were used to demonstrate expression of the regl gene in pancreas and liver. The proteins encoded by reg and regl comprise 166 amino acids and differ by 22 amino acids only.
Bartoli
C
C
Unité 315 de l'INSERM, Marseille, France.
Gharib
B
B
Giorgi
D
D
Sansonetti
A
A
Dagorn
J C
JC
Bergé-Lefranc
J L
JL
D000595:Amino Acid Sequence; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA; D015870:Gene Expression; D006801:Humans; D051847:Lithostathine; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D010179:Pancreas / Q000378:metabolism*; D010750:Phosphoproteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D002135:Calcium-Binding Proteins; D051847:Lithostathine; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; C497617:REG1A protein, human; D012333:RNA, Messenger; D004247:DNA