Lipoprotein abnormalities in hypertriglyceridaemic patients on long-term haemodialysis.
OBJECTIVE
To analyse by ultracentrifugation in a zonal rotor the plasma lipoproteins in hypertriglyceridaemic patients on long-term haemodialysis.


METHODS
Case-control study.


METHODS
Tertiary referred care centre.


METHODS
Ten consecutive hypertriglyceridaemic patients on haemodialysis and 12 consecutive healthy controls.


METHODS
Plasma lipid and lipoprotein cholesterol concentrations, lipoprotein physical properties and compositions, apolipoprotein concentrations.


RESULTS
Hypertriglyceridaemia in patients undergoing haemodialysis is characterized by an increased amount of small and slow floating very-low density lipoproteins (VLDL), higher concentrations of intermediate density lipoproteins (IDL) and small and dense low-density lipoprotein (LDL) particles; reduced levels of high-density lipoproteins (HDL), in particular of HDL2. The lipoprotein composition of such patients indicates reduced cholesterol ester and increased triglyceride content. Compared to controls, they have lower levels of plasma apolipoprotein A-I and A-II and higher B, C-II, C-III and E values.


CONCLUSIONS
The lipoprotein abnormalities observed in hypertriglyceridaemic patients undergoing haemodialysis have recently been associated with an increased incidence of vascular complications and may in part explain the high incidence of vascular disease reported in these subjects.
Zambon
S
S
Department of Internal Medicine, University of Padova, Italy.
Zambon
A
A
Stabellini
N
N
Tarroni
G
G
Gilli
P
P
Crepaldi
G
G
Manzato
E
E
D000368:Aged; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D014461:Ultracentrifugation
D008074:Lipoproteins