A multi-organ, axially distributed model of capillary permeability for a magnetic resonance imaging contrast agent.
Capillary permeability was resolved from uptake data for eight rat organs with gadoteridol, which is a stable, well-tolerated, nonionic, highly water soluble, gadolinium-containing, magnetic resonance imaging contrast agent. The extracellular kinetics were elucidated with an axially distributed, plasma interstitial fluid model and measured plasma flow, organ plasma volume, and interstitial fluid volume. The molecular and biological properties of gadoteridol and this kinetic model provide magnetic resonance imaging with a tool to begin measuring physiologic processes.
Eaton
S M
SM
Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903.
Wedeking
P
P
Tweedle
M F
MF
Eckelman
W C
WC
D000818:Animals; D002199:Capillary Permeability / Q000502:physiology*; D003287:Contrast Media / Q000493:pharmacokinetics*; D005682:Gadolinium; D006571:Heterocyclic Compounds / Q000493:pharmacokinetics; D007668:Kidney / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008954:Models, Biological; D009392:Nephrectomy; D009929:Organ Size / Q000502:physiology; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium