title: [Physiopathology of scleroderma].
abstract: Scleroderma (systemic sclerosis) is a connective tissue disease characterized by an excessive accumulation of collage in the main body organs. The subsequent progressive fibrosis may result in severe functional impairment of the tissue(s) involved. In this paper, recent advances in the understanding of the disease are reviewed. Particular emphasis is placed on the role played by vascular lesions, inflammatory cell infiltrates, autoimmunity and possibly abnormal secretion of cytokines in the disturbance of connective tissue production. A better knowledge of the pathophysiological process involved in scleroma might lead to the development of new therapeutic approaches.
authors.affiliation: Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: R
authors.initials: R
authors.lastname: Fleischmajer
authors.forename: J S
authors.initials: JS
authors.lastname: Perlish
authors.forename: F X
authors.initials: FX
authors.lastname: Maquart
authors.forename: B
authors.initials: B
authors.lastname: Kalis
mesh_terms: D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis; D002196:Capillaries / Q000473:pathology; D003094:Collagen / Q000032:analysis; D016207:Cytokines / Q000502:physiology; D005355:Fibrosis; D006801:Humans; D007111:Immunity, Cellular; D012595:Scleroderma, Systemic / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply
chemical_list: D001323:Autoantibodies; D016207:Cytokines; D003094:Collagen
vernacular_title: Physiopathologie de la sclérodermie.