Extraction and analysis by high-performance liquid chromatography of antibiotics in a drug delivery system for farmed fish.
Simple assays for extraction and determination of the concentrations of the antibiotics oxytetracycline, oxolinic acid, and flumequine in a drug dosage form for farmed fish are described. HPLC with UV detection was used in the analyses. The recovery of all three drugs was approximately 100%, and the precision varied from 0.5-3.0%. The methods are applicable to the production control, quality control, and stability control of the products.
Rogstad
A
A
Apothekernes Laboratorium, Oslo, Norway.
Weng
B
B
D016573:Agrochemicals / Q000032:analysis*; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis*; D000890:Anti-Infective Agents / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D005399:Fishes; D024841:Fluoroquinolones; D007202:Indicators and Reagents; D010093:Oxolinic Acid / Q000032:analysis; D010118:Oxytetracycline / Q000032:analysis; D011786:Quality Control; D011807:Quinolizines / Q000032:analysis; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D016573:Agrochemicals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007202:Indicators and Reagents; D011807:Quinolizines; D010093:Oxolinic Acid; C012976:flumequine; D010118:Oxytetracycline