Midline cerebral malformations and schizophrenia.
To investigate a possible association of midline cerebral malformations with psychotic disorders, MRI and CT scans were blindly evaluated for 52 patients with schizophrenia, 9 with schizoaffective disease, and 79 consecutive nonpsychotic control subjects. Midline abnormalities were present in 10 of 61 patients (16.4%) versus 4 of 79 control subjects (5.1%; P < 0.05, chi-square). Of 52 schizophrenic patients, 8 had abnormalities of the septum pellucidum (SP): 5 had cavum vergae (CaV), 2 had cavum septum pellucidum (CaSP), and 1 had agenesis of the corpus callosum and SP. Of 9 schizoaffective patients, 2 had SP abnormalities: 1 CaV and 1 CaSP. Abnormalities of the SP, especially CaV, were significantly more frequent in women than in men (P < 0.02, chi-square).
Scott
T F
TF
Department of Neurology, Medical College of Pennsylvania, Pittsburgh.
Price
T R
TR
George
M S
MS
Brillman
J
J
Rothfus
W
W
D000328:Adult; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging; D002552:Cerebral Ventricles / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D012189:Retrospective Studies; D012559:Schizophrenia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012688:Septum Pellucidum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed