title: [Secondary cases of meningococcal disease in The Netherlands, 1989-1990; a reappraisal of chemoprophylaxis].
abstract: OBJECTIVE
  To assess the secondary attack rate (SAR) of meningococcal disease among the household contacts of primary patients and to describe the use of chemoprophylaxis in the Netherlands.
  
  
  METHODS
  Descriptive, nation-wide survey.
  
  
  METHODS
  Information was collected of patients with meningococcal disease, reported between April 1st, 1989 and April 30th, 1990, and their household contacts. A household contact suffering from meningococcal disease between 24 hours and 1 month after hospital admission of the primary patient, was considered to be a secondary case. Chemoprophylaxis was considered appropriate if rifampicin or minocycline had been prescribed to all household contacts within a maximum of one day after admission of the primary patient.
  
  
  RESULTS
  There were 5 secondary cases (SAR: 0.3%). Chemoprophylaxis was prescribed to 627 of 1130 household contacts (55%). Of those the prophylaxis was considered appropriate in 46%. 2 secondary cases were not given any prophylaxis, 2 received penicillin and 1 rifampicin. Of the primary patients, 6% were given prophylaxis during their hospital stay. All meningococci, isolated from pairs of secondary and primary patients, were rifampicin sensitive.
  
  
  CONCLUSIONS
  The SAR of meningococcal disease in the Netherlands is similar to that in other countries. Although prescription of chemoprophylaxis is not recommended by the government, it is prescribed to 55% of the household contacts, and in almost half of these instances it was considered to be appropriate. Chemoprophylaxis is rarely prescribed to primary patients. Recommendations concerning chemoprophylaxis in the Netherlands are in need of reappraisal. Based on the results from this study and the literature, the prescription of chemoprophylaxis to all household contacts of a patient with meningococcal disease, and to the index patient, is recommended.
authors.affiliation: Vrije Universiteit, Instituut voor Extramuraal Geneeskundig Onderzoek, Amsterdam.
authors.forename: R J
authors.initials: RJ
authors.lastname: Scholten
authors.forename: H A
authors.initials: HA
authors.lastname: Bijlmer
authors.forename: J
authors.initials: J
authors.lastname: Dankert
authors.forename: H A
authors.initials: HA
authors.lastname: Valkenburg
mesh_terms: D000328:Adult; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D008911:Minocycline / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D008911:Minocycline; D012293:Rifampin
vernacular_title: Secundaire gevallen van meningokokkenziekte in Nederland, 1989-1990; chemoprofylaxe opnieuw bezien.