Effects of cicletanine on the urinary excretion of prostanoids and kallikrein, and on renal function in man.
The effects of cicletanine, a new antihypertensive agent, on the prostaglandin-kallikrein system and the renin-angiotensin system were studied. A single oral dose of 200 mg cicletanine or placebo was administered to 9 healthy male volunteers, with samples of blood and urine obtained before and 2 hours after drug administration. Cicletanine increased the urine flow, urinary excretion of sodium, and fractional excretion of sodium by 47%, 115%, and 104%, respectively. While the excretion of 6-keto-prostaglandin-F1 alpha was enhanced significantly, urinary excretion of thromboxane-B2, prostaglandin-E2, and kallikrein were unchanged. Cicletanine also did not alter plasma renin activity, plasma aldosterone concentration, or creatinine clearance. These observations suggest that cicletanine may suppress sodium reabsorption at the nephron, and it may stimulate prostacyclin generation with no effect on that of thromboxane-A2. Thus cicletanine may be beneficial in the management of cardiovascular disorders in which the equilibrium between prostacyclin and thromboxane is disturbed.
Tsunoda
K
K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Abe
K
K
Omata
K
K
Hagino
T
T
Minami
N
N
Munakata
M
M
Yoshida
K
K
Sakuma
H
H
Misawa
S
S
Arima
S
S
D000284:Administration, Oral; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001692:Biological Transport; D006801:Humans; D007610:Kallikreins / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D011453:Prostaglandins / Q000652:urine; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism; D014563:Urodynamics / Q000187:drug effects*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000959:Antihypertensive Agents; D011453:Prostaglandins; D011725:Pyridines; D000450:Aldosterone; D012964:Sodium; C038068:cicletanine; D007610:Kallikreins; D012083:Renin