title: Skin cancer caused by chronic arsenical poisoning--a report of three cases.
abstract: The association of arsenical poisoning with the development of skin cancer is well-known. In Malaysia, arsenic has been shown to coexist with tin in tin-mining land. Our preliminary investigation has shown that the level of arsenic in well water from a tin-mining area is high. We report 3 patients with cutaneous lesions typical of chronic arsenical poisoning such as hyperpigmentation, keratoses and skin cancer. These patients have positive histories of previous domicility in tin-mining areas. We conclude that these patients developed chronic arsenical poisoning from drinking well water polluted with arsenic from the tin-mining soil.
authors.affiliation: Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
authors.forename: R
authors.initials: R
authors.lastname: Jaafar
authors.forename: I
authors.initials: I
authors.lastname: Omar
authors.forename: A J
authors.initials: AJ
authors.lastname: Jidon
authors.forename: B W
authors.initials: BW
authors.lastname: Wan-Khamizar
authors.forename: B M
authors.initials: BM
authors.lastname: Siti-Aishah
authors.forename: S H
authors.initials: SH
authors.lastname: Sharifah-Noor-Akmal
mesh_terms: D000328:Adult; D020261:Arsenic Poisoning; D002277:Carcinoma / Q000139:chemically induced*; D002278:Carcinoma in Situ / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D008906:Mining; D012878:Skin Neoplasms / Q000139:chemically induced*; D014001:Tin; D014877:Water Pollution, Chemical; D014881:Water Supply
chemical_list: D014001:Tin