title: A novel macrolactam-disaccharide antifungal antibiotic. Taxonomy, fermentation, isolation, physico-chemical properties, structure elucidation and biological activity.
abstract: A novel natural product (1), with antifungal activity was isolated from the culture broth of an actinomadurae. The active compound was separated from broth by n-butanol extraction and purified by silica gel and multicoil counter current chromatography. Physico-chemical data suggested the structure of this compound to be a novel macrolactam disaccharide related to Sch 38518 (3). The structure was determined by spectroscopic studies on the acetate derivative. It was active against Candida spp. (MIC's, 4 approximately 64 micrograms/ml) but less than the monosaccharide, Sch 38518 (MIC's, 1 approximately 16 micrograms/ml).
authors.affiliation: Schering-Plough Research Institute, Kenilworth, NJ 07033.
authors.forename: V R
authors.initials: VR
authors.lastname: Hegde
authors.forename: M G
authors.initials: MG
authors.lastname: Patel
authors.forename: V P
authors.initials: VP
authors.lastname: Gullo
authors.forename: A C
authors.initials: AC
authors.lastname: Horan
authors.forename: A H
authors.initials: AH
authors.lastname: King
authors.forename: F
authors.initials: F
authors.lastname: Gentile
authors.forename: G H
authors.initials: GH
authors.lastname: Wagman
authors.forename: M S
authors.initials: MS
authors.lastname: Puar
authors.forename: D
authors.initials: D
authors.lastname: Loebenberg
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000145:classification / Q000378:metabolism; D018942:Macrolides; D015394:Molecular Structure
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C075536:Sch 38518