Unusual rheumatological and cardiological manifestations of acute myelogenous leukemia in a patient with Klinefelter's syndrome.
We report the case of a 40-year-old man with Klinefelter's syndrome who presented with a complex multisystem illness, the predominant manifestations of which were rheumatological and cardiological. This disorder coincided with a diagnosis of acute myelogenous leukemia evolving out of a myelodysplastic syndrome and resolved completely after chemotherapy. It is concluded that the hematological malignancy probably played a causal role in the development of this unusual illness which was likely immunologically mediated.
Dow
G
G
Division of Hematology, Vancouver General Hospital, British Columbia, Canada.
Reid
G D
GD
Horsman
D E
DE
Barnett
M J
MJ
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D002872:Chromosome Deletion; D005334:Fever / Q000209:etiology; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008297:Male; D010996:Pleural Effusion / Q000209:etiology; D011289:Preleukemia / Q000150:complications; D012216:Rheumatic Diseases / Q000209:etiology* / Q000276:immunology