title: Bioactive and other sesquiterpenoids from Porella cordeana.
abstract: Bioassay-directed fractionation of the MeCOEt extract of Porella cordeana yielded drimenin [1] and aristolone [4], which were moderately toxic towards DNA-repair-deficient mutants of Saccharomyces cerevisiae. Three inactive sesquiterpenes, 7-ketoisodrimenin [2], 7-ketoisodrimenin-5-ene [3], and norpinguisanolide, were also obtained. Compounds 2 and 3 are new.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
authors.forename: G G
authors.initials: GG
authors.lastname: Harrigan
authors.forename: A
authors.initials: A
authors.lastname: Ahmad
authors.forename: N
authors.initials: N
authors.lastname: Baj
authors.forename: T E
authors.initials: TE
authors.lastname: Glass
authors.forename: A A
authors.initials: AA
authors.lastname: Gunatilaka
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D012717:Sesquiterpenes