title: [Evaluation of the effect of the sodium hyaluronate ophthalmic solution on tear film stability--non-contact specular microscopic evaluation].
abstract: Sodium hyaluronate solution is known to relieve various dry eye symptoms by suppressing the breakup of the preocular tear film. Using tear film stability as a parameter, we examined in 12 volunteers the time and concentration-dependent effects of sodium hyaluronate on their short precorneal tear film breakup time (BUT, 10 sec. or less) at a low tear volume (15 mm or less by using the phenol red thread test). Each subject underwent four separate study periods, receiving one of the following four ophthalmic solutions during each period: 0.05, 0.1, 0.3% w/v sodium hyaluronate (molecular weight, about 1,000,000) or the vehicle alone. BUT was measured non-invasively using a non-contact specular microscope before and 5, 15, 30, 60, 120, and 180 minutes after drug application. While BUT was not significantly prolonged after instilling either the vehicle or 0.05% solution, it was significantly increased at all times after applying either 0.1% or 0.3% solution, as compared to preinstillation. These results indicate that sodium hyaluronate solutions at concentrations of at least 0.1% can be effective in alleviating symptoms of dry eye.
authors.affiliation: Department of Ophthalmology, Osaka Seamen's Insurance Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hamano
authors.forename: K
authors.initials: K
authors.lastname: Horimoto
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Komemushi
mesh_terms: D000328:Adult; D015352:Dry Eye Syndromes / Q000188:drug therapy; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008853:Microscopy / Q000379:methods; D009883:Ophthalmic Solutions; D013666:Tears / Q000187:drug effects*; D013997:Time Factors
chemical_list: D009883:Ophthalmic Solutions; D006820:Hyaluronic Acid