title: Cardiovascular and renal effects of hypoxia in conscious carotid body-denervated rats.
abstract: The contribution of peripheral arterial chemoreceptors to cardiovascular and renal responses to acute hypocapnic hypoxia is currently not well understood. We compared the effects of normobaric hypoxia on mean arterial blood pressure (MABP), heart rate, glomerular filtration rate (GFR), renal blood flow (RBF), and renal volume and electrolyte excretion in conscious unilaterally nephrectomized carotid body-denervated (n = 10) and sham-operated (n = 10) control rats. Thirty minutes of normobaric hypoxia (12.5% O2) resulted in significant reductions in arterial PO2 and PCO2 as well as decreases in MABP, GFR, RBF, and renal sodium, potassium, and water excretion. These effects occurred more rapidly and/or were significantly more pronounced in carotid body-denervated than in sham-operated rats. These data indicate that moderate acute hypocapnic hypoxia has profound effects on systemic and renal hemodynamics as well as on renal excretory function in conscious rats. We conclude that stimulation of the peripheral arterial chemoreceptors can partially offset the hypoxia-induced decreases in MABP, RBF, GFR, urine flow, and urinary sodium and potassium excretion, thereby helping to maintain cardiovascular as well as fluid and electrolyte homeostasis.
authors.affiliation: Department of Pharmacology, University of Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Behm
authors.forename: H
authors.initials: H
authors.lastname: Mewes
authors.forename: W H
authors.initials: WH
authors.lastname: DeMuinck Keizer
authors.forename: T
authors.initials: T
authors.lastname: Unger
authors.forename: R
authors.initials: R
authors.lastname: Rettig
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002319:Cardiovascular System / Q000503:physiopathology*; D002344:Carotid Body / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000503:physiopathology; D003714:Denervation; D005919:Glomerular Filtration Rate / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000502:physiology; D012964:Sodium / Q000652:urine
chemical_list: D012964:Sodium; D011188:Potassium