Polygenic disease.
Considerable success is now being achieved in defining genetic susceptibility loci in polygenic disease. In particular, new susceptibility loci have been identified in hypertension, type I and type II diabetes, asthma and malaria infection. The approaches and tools for mapping such susceptibility determinants are becoming more clearly defined and the identification of further susceptibility genes is likely to be in demand in the near future.
Bell
J I
JI
Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK.
D000818:Animals; D001249:Asthma / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics