Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin.
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Division of Pharmaceutics, College of Pharmacy, Ohio State University, Columbus 43210-1291.
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D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000378:metabolism / Q000493:pharmacokinetics; D001665:Binding Sites; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D000077146:Irinotecan; D007783:Lactones / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012709:Serum Albumin; D000077146:Irinotecan; D002166:Camptothecin