title: [D-dimer and plasminogen activator of the urokinase type: personal experiences with breast cancer].
abstract: Plasma values of d-dimer, a stable end product of plasmin-induced fibrinolysis, were ascertained in 128 female patients with mammary carcinoma. These patients demonstrated significantly increased d-dimers in comparison with the control group with benign mammary disease (p < 0.01). The sensitivity and specificity of d-dimer were slightly higher than those of the established tumour marker CA 15-3 and CEA. There was no correlation between d-dimers in the plasma and increased expression of urokinase plasminogen activator (UPA) in the tissue. Increased d-dimers in the plasma of female patients with mammary carcinoma reflect multi-factoral interactions between carcinoma growth and the haemostatic-fibrinolytic system, and may be used as tumour markers.
authors.affiliation: Frauenklinik, Fakultät für Klinische Medizin, Universität Heidelberg, Klinikum Mannheim.
authors.forename: M
authors.initials: M
authors.lastname: Neises
authors.forename: T
authors.initials: T
authors.lastname: Schäfer
authors.forename: H J
authors.initials: HJ
authors.lastname: Strittmatter
authors.forename: A
authors.initials: A
authors.lastname: Wischnik
authors.forename: P
authors.initials: P
authors.lastname: Dettmar
authors.forename: F
authors.initials: F
authors.lastname: Melchert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000097:blood; D003131:Combined Modality Therapy; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D015409:Mastectomy, Radical; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000201:enzymology; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000201:enzymology / Q000601:surgery; D012307:Risk Factors; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: D-Dimer und Plasminogen Aktivator vom Urokinasetyp: Eigene Erfahrungen bei Mammakarzinomen.