title: [HIV-related non-Hodgkin lymphoma in 45 patients; a retrospective analysis].
abstract: Non-Hodgkin lymphoma is seen in approximately 5% of patients with AIDS. In recent years, the incidence has increased due to an extension of the average lifespan of HIV-infected individuals. In this article we describe the histological and clinical features of 45 patients with HIV-related non-Hodgkin lymphoma seen at the Academic Medical Centre between 1984 and 1991. There were 43 men and 2 women with a median age of 40 years. Most patients had high-grade B-cell lymphoma; 85% had extranodal sites. Prognosis was poor: overall median survival was only 3.8 months. Twelve patients were treated with 3 or more courses of chemotherapy: their median survival was 8 months. In 7 of 12 patients a complete remission was obtained; their median survival was 18 months. A history of AIDS was a poor prognostic factor.
authors.affiliation: Afd. Interne Geneeskunde, Academisch Medisch Centrum, Amsterdam.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kersten
authors.forename: M J
authors.initials: MJ
authors.lastname: Mertens
authors.forename: S T
authors.initials: ST
authors.lastname: Pals
authors.forename: P
authors.initials: P
authors.lastname: Reiss
authors.forename: M H
authors.initials: MH
authors.lastname: van Oers
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016019:Survival Analysis
vernacular_title: Met HIV samenhangend non-Hodgkin-lymfoom bij 45 patiënten; een retrospectieve analyse.