Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone.
The synthetic C-terminal peptide fragment of human growth hormone, Leu-Arg-Ile-Val Gln-Cys-Arg-Val-Ser-Glu-Gly-Ser-Cys-Gly-Phe (hGH 177-191), was shown to have antilipogenic activity identical with that of the intact molecule of human growth hormone (hGH). No significant lipolytic effect of hGH 177-191 was found as determined by the rate of glycerol release from epididymal fat pads of the peptide-treated rats. The results support the suggestion that the functional domain responsible for the antilipogenic activity of hGH resides in the C-terminal region of the molecule and that the main physiological effect of hGH in lipid metabolism is at the level of lipogenesis.
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Department of Biochemistry, Monash University, Clayton, Victoria, Australia.
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D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002784:Cholesterol / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology; D005990:Glycerol / Q000097:blood / Q000378:metabolism; D013006:Growth Hormone / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis*; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D008055:Lipids; D010446:Peptide Fragments; D014280:Triglycerides; C035327:somatotropin (177-191); D003907:Dexamethasone; D013006:Growth Hormone; D002784:Cholesterol; D005990:Glycerol