Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.
A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's antihypertensive effect occurred within 4 hours. In contrast, hydrochlorothiazide (HCTZ) increased serum concentrations of urea, triglycerides, and glucose, without affecting cholesterol.
Beyer
K H
KH
Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033.
Ward
T D
TD
Vary
J E
JE
Gelarden
R T
RT
Knutson
D W
DW
Vesell
E S
ES
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004573:Electrolytes / Q000097:blood; D005260:Female; D006146:Guanidines / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D006852:Hydrochlorothiazide / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011719:Pyrazines / Q000097:blood / Q000494:pharmacology*; D051437:Renal Insufficiency / Q000097:blood*; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D004573:Electrolytes; D006146:Guanidines; D011719:Pyrazines; D014280:Triglycerides; D006852:Hydrochlorothiazide; C056104:2-pyrazinoylguanidine; D014508:Urea; D002784:Cholesterol