title: [99mTc-MAG3-kidney function scintigraphy without and with captopril in the diagnosis of renovascular hypertension].
abstract: In this study, the diagnostic value of renal function scintigraphy performed both without and with ACE inhibition has been evaluated using the new radiopharmaceutical 99mTc-MAG3. In cases of decompensated renal artery stenoses, the typical scan finding with this tubular excreted agent was shown to be a distinct parenchymal nuclide retention in combination with a delayed appearance of the radiotracer in the pelvic system. Using this criterion in 43 patients with suspected renovascular hypertension, sensitivity and specificity were 89 and 88%, respectively. Bilateral positive findings were non-specific; excluding them from the study, specificity increased to 100%. In renal insufficiency, captopril scans seem to be of reduced diagnostic value. Summarising our experiences, renal function scintigraphy using 99mTc-MAG3 without and with captopril was proved to be a reliable non-invasive method to detect or exclude haemodynamically relevant renal artery stenosis.
authors.affiliation: Klinik mit Poliklinik für Nuklearmedizin, Johannes-Gutenberg-Universität, Mainz.
authors.forename: R
authors.initials: R
authors.lastname: Piepenburg
authors.forename: A
authors.initials: A
authors.lastname: Bockisch
authors.forename: J
authors.initials: J
authors.lastname: Andreas
authors.forename: C
authors.initials: C
authors.lastname: Düber
authors.forename: P
authors.initials: P
authors.lastname: Kann
authors.forename: G
authors.initials: G
authors.lastname: Maier
authors.forename: K
authors.initials: K
authors.lastname: Hahn
mesh_terms: D002216:Captopril / Q000008:administration & dosage; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D017263:Technetium Tc 99m Mertiatide
chemical_list: D017263:Technetium Tc 99m Mertiatide; D002216:Captopril
vernacular_title: 99mTc-MAG3-Nierenfunktionsszintigraphie ohne und mit Captopril zur Diagnostik der renovaskulären Hypertonie.