Verucopeptin, a new antitumor antibiotic active against B16 melanoma. I. Taxonomy, production, isolation, physico-chemical properties and biological activity.
A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It should potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D x 1 treatment schedule.
Nishiyama
Y
Y
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Sugawara
K
K
Tomita
K
K
Yamamoto
H
H
Kamei
H
H
Oki
T
T
D000192:Actinomycetales / Q000737:chemistry*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D005285:Fermentation; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010456:Peptides, Cyclic; C082424:verucopeptin