Preliminary results of short-term combination immunosuppressions of mizoribine, azathioprine, and prednisolone with pretreatment to canine kidney transplantation.
Serial combinations of immunosuppressive drugs (mizoribine: Mi, azathioprine: Az, and prednisolone: Pr) were administered for renal heterotopic allotransplantation in 50 mixed-breed dogs and 4 beagle dogs. The dogs were randomly divided in 5 groups depending upon immunosuppressive protocols. All immunosuppressive protocols were started at 5 days prior to transplantation and discontinued on the eighth day after transplantation. The mean survival time for the allograft recipients in the group receiving Az and Pr [Az (2.5) & Pr group; Az dosage, 2.5 mg/kg once a day with Pr] was 16.2 +/- 2.4 days and in the group receiving Az, Mi, and Pr (Mi & Az & Pr group; Mi dosage, 5.0 mg/kg once a day with Az and Pr), it was 14.0 +/- 2.6 days. These results were significantly longer than the control group (mean survival time, 8.7 +/- 2.4 days; P < 0.01). There was no statistical difference in survival time between these two groups. Groups with combinations of Az and Pr had significant elevations of hepatic enzymes (ALT and ALP) during the 7 days of immunosuppressive treatment after kidney transplantation. The Mi & Az & Pr group had lower elevations of hepatic enzymes than groups with combinations of Az and Pr. The combination immunosuppression of Mi, Az, and Pr with pre-treatment for canine, kidney transplantation revealed relatively fewer side-effects for the liver and longer survival-time.
Minami
T
T
Department of Veterinary Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Watanabe
T
T
Muto
M
M
Wakao
Y
Y
Suzuki
T
T
Takahashi
M
M
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004359:Drug Therapy, Combination; D006085:Graft Survival / Q000187:drug effects; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology* / Q000502:physiology; D011239:Prednisolone / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*; D013997:Time Factors; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D011239:Prednisolone; D003404:Creatinine; D000410:Alanine Transaminase; D001379:Azathioprine