title: POU-domain proteins: structure and function of developmental regulators.
abstract: POU-domain proteins are a group of developmental regulators found in organisms as distant as worm and man. The sequence conservation of the POU-domain has allowed the characterization of increasing numbers of proteins containing the domain, many of which act to control the generation and maintenance of differentiated cell phenotypes in organs as diverse as skin and brain. Analysis of the means by which POU-domain proteins regulate transcription has led to a further understanding of how this group initiates specific developmental programs.
authors.affiliation: Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla 92093-0648.
authors.forename: M
authors.initials: M
authors.lastname: Wegner
authors.forename: D W
authors.initials: DW
authors.lastname: Drolet
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D050809:POU Domain Factors; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D050809:POU Domain Factors; D014157:Transcription Factors; D004247:DNA