title: [A case of so-called benign metastasizing leiomyoma responsive to progesterone].
abstract: A 47-year-old female, who had undergone hysterectomy and unilateral oophorectomy in 1975, was admitted to our hospital in 1989 because chest X-ray films revealed an increase in size and number of pulmonary nodules for two years. On admission, a left inguinal tumor was found and histologically it consisted of smooth muscle cells with nuclear atypia arranged in interlacing fascicles. An open-lung biopsy was performed. Pulmonary tumors revealed similar histology to the inguinal tumor. They were diagnosed as metastatic low-grade leiomyosarcoma, so-called benign metastasizing leiomyoma (BML), on the basis of location and history, reinforced by mild histologic atypia. The tumor contained a high progesterone receptor level (400 fmol/mg). Therefore, medroxyprogesterone acetate, 600 mg daily, was administered orally. At two years the pulmonary lesions had regressed. BML is a rare condition, considered to be pulmonary metastasis from low-grade leiomyosarcoma of the uterus. Measuring estrogen and progesterone receptors in lung biopy material may help determine the most appropriate therapy.
authors.affiliation: Second Department of Internal Medicine, Gunma University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Motegi
authors.forename: N
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Y
authors.initials: Y
authors.lastname: Sando
authors.forename: M
authors.initials: M
authors.lastname: Ubukata
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: I
authors.initials: I
authors.lastname: Yoshida
mesh_terms: D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy / Q000556:secondary*; D007890:Leiomyosarcoma / Q000188:drug therapy / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D008875:Middle Aged; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000473:pathology*
chemical_list: D008525:Medroxyprogesterone