p53 protein expression in Reed-Sternberg cells of Hodgkin's disease.
Hodgkin's disease (HD) is perceived to be a malignant disease of the lymphoid system. One of the main obstacles into the investigation of the cell biology of Hodgkin's disease is the relative paucity of Reed-Sternberg cells (or variants), the presumed neoplastic component of this condition, which often make up less than 1% of the total cell number.
Gupta
R K
RK
ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, England, UK.
Norton
A J
AJ
Lister
T A
TA
Bodmer
J G
JG
D002467:Cell Nucleus / Q000737:chemistry; D016158:Genes, p53 / Q000235:genetics; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D016539:Reed-Sternberg Cells / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D016159:Tumor Suppressor Protein p53