Familial lupoid thrombocytopenia.
Familial lupoid thrombocytopenia affecting three subjects in three generations is reported. All subjects had antinuclear antibodies with or without antibodies to single-stranded DNA, an increase in platelet-associated IgG, and a family member with an autoimmune disease. These findings implicate a genetic contribution. All subjects shared a common HLA haplotype.
Shimizu
K
K
Department of Medicine, Fujita Health University School of Medicine, Nagoya, Japan.
Katsuta
I
I
Uchikawa
T
T
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics; D001792:Blood Platelets / Q000276:immunology; D004277:DNA, Single-Stranded / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005192:Family Health; D005260:Female; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013921:Thrombocytopenia / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology
D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D006680:HLA Antigens; D007074:Immunoglobulin G