[Impaired function of polymorphonuclear neutrophilic granulocytes in rheumatoid arthritis].
The aim of this study was to investigate the PMN functions ingestion (I), bacterial killing (BK) as well as the chemiluminescence response to phorbol esters (PMACL) as a measure of PMN respiratory burst activity in RA compared to osteoarthritis and controls. Our findings demonstrated a significant reduction of I and BK in RA compared to OA and controls (p < 0.01 resp.) but an enhanced PMACL (p < 0.01). There was no significant difference of I, BK and PMACL in OA and control subjects. These data clearly demonstrated impaired PMN ingestion and bacterial killing yet enhanced PMACL in RA, thus contributing at least in part to altered host defense in these patients.
Marhoffer
W
W
Medizinische Klinik III und Poliklinik, Universität Giessen.
Stein
M
M
Federlin
K
K
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001770:Blood Bactericidal Activity; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000276:immunology*; D010003:Osteoarthritis / Q000276:immunology; D010587:Phagocytosis; D016897:Respiratory Burst; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D013755:Tetradecanoylphorbol Acetate
Eingeschränkte Funktion polymorphkerniger neutrophiler Granulozyten bei rheumatoider Arthritis.