Kinetics of amorolfine in human nails.
Amorolfine penetrates rapidly into the nail after topical application. The kinetics of penetration follow an exponential law as expected, and the level of amorolfine measured in the nail (at least in the upper levels) already exceeds the MIC of most fungi causing onychomycosis after only 24 h of contact. After topical application amorolfine is detectable in the nail earlier and in higher concentrations than terbinafine and itraconazole after oral application.
Polak
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F. Hoffmann-La Roche Ltd, Pharma Division, Preclinical Research, Basel, Switzerland.
D000287:Administration, Topical; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D006801:Humans; D009025:Morpholines / Q000493:pharmacokinetics*; D009262:Nails / Q000378:metabolism*
D000935:Antifungal Agents; D009025:Morpholines; C038974:amorolfine