Assessment of the mutagenic activity of some acenaphtho(1,2-b)quinolines.
The mutagenic activity of four substituted acenaphtho(1,2-b)quinolines were evaluated using the Ames test (Salmonella assay). The compounds tested were acenaphtho(1,2-b)quinoline (1) and its 10-methoxy (2), 10-methyl (3) and 10-nitro (4) derivatives. Compounds 1 and 3 were found to be non-mutagenic, but compound 2 was found to be mutagenic with metabolic activation only. However, compound 4 was found to be very active with or without activation.
Ray
J K
JK
Department of Chemistry, Indian Institute of Technology, Kharagpur.
Kar
G K
GK
D000073:Acenaphthenes / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D000073:Acenaphthenes; D009153:Mutagens