The structures of aplysinamisines I, II, and III; new bromotyrosine-derived alkaloids from the Caribbean sponge Aplysina cauliformis.
Three new bromotyrosine-derived alkaloids, aplysinamisines I [4], II [5], and III [6], were isolated from the sponge Aplysina cauliformis collected in Puerto Rico and their chemical structures elucidated on the basis of spectroscopic methods. Compounds 4-6 showed marginal antimicrobial activity, and aplysinamisines II [5] and III [6] displayed modest cytotoxicity.
Rodríguez
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Department of Chemistry, University of Puerto Rico, Río Piedras 00931-3346.
Piña
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology; D011161:Porifera / Q000378:metabolism*; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010080:Oxazoles; D013141:Spiro Compounds; C082607:aplysinamisine I; C082608:aplysinamisine II; C082609:aplysinamisine III; D014443:Tyrosine; C082610:3,5-dibromotyrosine