title: Control of hemorrhage during renal failure with triglycyl-lysine-vasopressin.
abstract: A 35-year-old man with chronic renal failure developed toxic epidermal necrolysis due to combination antibiotic therapy for a community acquired pneumonia. During wound care for his toxic epidermal necrolysis, he developed massive bleeding, a 4 to 6 unit blood loss at each dressing change, due to uremia-associated platelet dysfunction and thrombocytopenia. After failure of standard therapy, the man was treated with intravenous triglycyl-lysine-vasopressin, a selective peripheral vasoconstrictor. Transfusion requirements stopped during treatment. This man went on to full recovery with complete wound healing. Triglycyl-lysine-vasopressin effectively reduced skin blood loss in this man with toxic epidermal necrolysis and an intrinsic hemostatic defect, and may be useful in other patients with cutaneous blood loss.
authors.affiliation: Department of Surgery, University of Michigan Medical Center, Ann Arbor.
authors.forename: W L
authors.initials: WL
authors.lastname: Garner
authors.forename: J L
authors.initials: JL
authors.lastname: Rodriguez
authors.forename: P D
authors.initials: PD
authors.lastname: Thomson
authors.forename: F C
authors.initials: FC
authors.lastname: Brosius
authors.forename: D J
authors.initials: DJ
authors.lastname: Smith
mesh_terms: D000328:Adult; D001458:Bandages; D002056:Burns / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008236:Lypressin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D000077585:Terlipressin
chemical_list: D008236:Lypressin; D000077585:Terlipressin