Suppression of plasma endothelin-1 level by alpha-human atrial natriuretic peptide and angiotensin converting enzyme inhibition in normal men.
The effect of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) on plasma endothelin-1 (ET-1) level was examined in 6 healthy subjects. Intravenous infusion of alpha-ANP (0.1 micrograms/kg/min) resulted in significant falls in plasma renin activity and aldosterone, but without effect on ET-1 level. An angiotensin converting enzyme inhibitor, captopril, increased plasma renin activity and decreased aldosterone, respectively. However, plasma ET-1 levels were not modified by captopril. In cases with alpha-hANP infusion after captopril (25 mg, p.o.,), the renin-angiotensin-aldosterone system was further inhibited compared with the first group, and ET-1 at 60 min was significantly suppressed from the baseline. These data suggest that alpha-hANP when combined with captopril brings about the suppression of plasma ET-1 concentrations in men.
Uemasu
J
J
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Matsumoto
H
H
Kitano
M
M
Kawasaki
H
H
D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004231:Diuresis; D016232:Endothelins / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D012016:Reference Values; D012083:Renin / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D012964:Sodium / Q000652:urine
D016232:Endothelins; D012709:Serum Albumin; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D002216:Captopril; D012964:Sodium; D012083:Renin