title: Epidural morphine in goats after hindlimb orthopedic surgery.
abstract: Morphine (0.1 mg/kg) diluted with 0.9% saline to a volume of 0.13 mL/kg was administered into the epidural space at the lumbosacral junction in 10 halothane-anesthetized goats immediately before discontinuation of halothane. The same volume of 0.9% saline was given to control group of eight anesthetized goats. Both groups had undergone an orthopedic procedure that replaced the anterior cruciate ligament with a patellar tendon autograft. The appearance and unprovoked behavior of goats in the morphine group were significantly different (p < .05) from the saline groups. The goats in the morphine group were more sedate and struggled less during recovery. Epidural morphine did not produce respiratory depression or bloat during a 9 hour observation period. Heart rate, respiratory rate, and blood pressure (mean, systolic, and diastolic) of the morphine group did not differ from those of the control group.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
authors.forename: L S
authors.initials: LS
authors.lastname: Pablo
mesh_terms: D015360:Analgesia, Epidural / Q000662:veterinary*; D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery; D006041:Goats / Q000502:physiology*; D006221:Halothane; D006439:Hemodynamics / Q000187:drug effects*; D006614:Hindlimb; D009020:Morphine / Q000494:pharmacology*; D010149:Postoperative Pain / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary*; D012119:Respiration / Q000187:drug effects; D013710:Tendons / Q000637:transplantation
chemical_list: D009020:Morphine; D006221:Halothane