A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure.
The efficacy of the interferon stimulator named Stronger Neo Minophagen-C (SNMC) derived form the plant G. glabra was studied at a dose of 40 or 100 ml daily for 30 days followed by thrice weekly intravenously for 8 wk in 18 patients of subacute hepatic failure due to viral hepatitis. The survival rate amongst these patients was 72.2 per cent, as compared to the earlier reported rate of 31.1 per cent in 98 patients who received supportive therapy (P < 0.01). Death in four of the five patients was due to associated infections leading to hepatorenal failure and terminal coma. Further studies are necessary to standardize the dose and duration of therapy with SNMC in subacute hepatic failure.
Acharya
S K
SK
Department of Gastroenterology & Human Nutrition, All India Institute of Medical Sciences, New Delhi.
Dasarathy
S
S
Tandon
A
A
Joshi
Y K
YK
Tandon
B N
BN
D000293:Adolescent; D000328:Adult; D003545:Cysteine / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005998:Glycine / Q000627:therapeutic use*; D006035:Glycyrrhiza / Q000737:chemistry*; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use*; D017093:Liver Failure / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010946:Plants, Medicinal
D004338:Drug Combinations; D007369:Interferon Inducers; D009828:Oleanolic Acid; C009781:neominophagen C; D003545:Cysteine; D005998:Glycine