[The effect of calcium antagonists on carbohydrate and lipid metabolism in diabetes mellitus].
The effect of calcium antagonists: nifedipine (corinfar, cordapheg), sensit, finoptin, foridon on carbohydrate and lipid metabolism was studied in intact and "alloxaned" rats as well as in non-insulin-dependent diabetes patients. It was found that the calcium channel blockers did not change glucose tolerance, normalized carbohydrate metabolism in some patients and decreased the level of triglycerides, B and pro-B lipoproteins. In some cases in intact and alloxane rats treated with finophin (isoptin), lactate decrease in blood and a tendency to insulin increase were often observed. The lipid metabolism was unchanged.
Morugova
T V
TV
Kamilov
F Kh
FKh
Lazareva
D N
DN
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002241:Carbohydrates / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats
D002121:Calcium Channel Blockers; D002241:Carbohydrates; D008055:Lipids
Vliianie antagonistov kal'tsiia na obmen uglevodov i lipidov pri sakharnom diabete.