Reproductive toxicity of vincristine in male rats.
Gross morphological and gravimetric changes were observed in the male reproductive system of sexually mature rats as well as rats in pubertal transition, given a continuous treatment of vincristine at dose levels of 10/20 and 5/10 micrograms respectively per day, for 15 days. The treatment resulted in a drastic regression of entire male reproductive system, suggesting that vincristine would cause male reproductive toxicity.
Stanley
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A
School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
Averal
H I
HI
Akbarsha
M A
MA
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014750:Vincristine / Q000633:toxicity*
D014750:Vincristine