Differential pattern of beta-amyloid protein deposition within cortical sulci and gyri in Alzheimer's disease.
We have quantified the pattern of beta-amyloid protein (beta AP) deposition in the sulci and gyri of the frontal cortex in Alzheimer's disease. The distribution pattern in the frontal cortex gyri is unequivocally different from the pattern found in the frontal sulci. These findings, in conjunction with our previous studies, reflect a differential vulnerability between the sulci and the gyri with respect to Alzheimer's disease pathology, sulci being affected to a greater extent. It is probable that the different patterns of deposition relate to the underlying cytoarchitecture of the cortex.
Clinton
J
J
Department of Anatomy and Cell Biology, St Mary's Hospital Medical School, Imperial College, London.
Roberts
G W
GW
Gentleman
S M
SM
Royston
M C
MC
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000276:immunology / Q000378:metabolism*; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology
D016229:Amyloid beta-Peptides