title: Cytotoxic and antibacterial effects of orthodontic appliances.
abstract: The cytotoxic and antibacterial effects of orthodontic appliances were assessed. Metallic devices used in orthodontics, such as molar bands, brackets, and archwires were tested by the agar overlay cytotoxicity test with mouse fibroblast cells. The same devices were tested for antibacterial effect with Streptococcus mutans and S. sanguis. The multicomponent devices, which are bonded with silver- and copper-based brazing alloys, were more cytotoxic than the single-component devices, probably because copper is more cytotoxic than nickel. The devices had a definite, but low, antibacterial effect, as compared with the 0.05% chlorhexidine positive control. A cytotoxic effect of the devices per se might contribute to a localized gingivitis. It is uncertain whether orthodontic devices have any significant inhibitory effect on dental plaque viability.
authors.affiliation: NIOM, Scandinavian Institute of Dental Materials, Haslum, Norway.
authors.forename: M R
authors.initials: MR
authors.lastname: Grimsdottir
authors.forename: A
authors.initials: A
authors.lastname: Hensten-Pettersen
mesh_terms: D000818:Animals; D003343:Corrosion; D003722:Dental Alloys / Q000494:pharmacology / Q000633:toxicity*; D003773:Dental Plaque / Q000382:microbiology; D005347:Fibroblasts; D005891:Gingivitis / Q000209:etiology; D005779:Immunodiffusion; D051379:Mice; D009532:Nickel / Q000494:pharmacology / Q000633:toxicity; D009967:Orthodontic Appliances / Q000009:adverse effects*; D013193:Stainless Steel / Q000494:pharmacology / Q000633:toxicity; D013295:Streptococcus mutans / Q000187:drug effects*; D013298:Streptococcus sanguis / Q000187:drug effects; D014025:Titanium / Q000494:pharmacology / Q000633:toxicity
chemical_list: D003722:Dental Alloys; C040654:titanium nickelide; D013193:Stainless Steel; D009532:Nickel; D014025:Titanium