title: Noradrenergic-GABAergic interaction in anterior hypothalamus from normotensive and sinoaortic denervated rats.
abstract: 1. GABA content is decreased in anterior hypothalamus and medulla oblongata of hypertensive rats by sinoaortic denervation (SAD) when compared to control animals which underwent a sham-operation (sham). 2. Lesion of noradrenergic pathways by 6-hydroxydopamine (6-OHDA), intracerebroventricularly administered, induced depletion of noradrenergic content in frontal cortex, anterior and posterior hypothalamus in both SAD and sham-operated rats. 3. As a consequence of this noradrenergic depletion there was an increase of GABA content in anterior hypothalamus only, from sham- and SAD-operated animals, without changes in other areas. 4. There is a noradrenergic-GABAergic interaction in the anterior hypothalamus of normotensive rats which is not impaired in hypertensive rats by sinoaortic denervation.
authors.affiliation: Instituto de Investigaciones Farmacológicas--CONICET, Buenos Aires, Argentina.
authors.forename: D
authors.initials: D
authors.lastname: Solignac
authors.forename: M A
authors.initials: MA
authors.lastname: Enero
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D003714:Denervation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007032:Hypothalamus, Anterior / Q000502:physiology*; D007276:Injections, Intraventricular; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D016627:Oxidopamine / Q000008:administration & dosage / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects; D012849:Sinoatrial Node / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000502:physiology*
chemical_list: D010656:Phenylephrine; D005680:gamma-Aminobutyric Acid; D016627:Oxidopamine; D009638:Norepinephrine