title: [Value of ketoconazole in the treatment of Cushing disease].
abstract: Ketoconazole has been successfully used in short-term treatment of Cushing's syndrome. We treated 4 patients who had Cushing's disease with ketoconazole administered during 5 to 18 months. Two of them are still controlled after 15 months of treatment and 7 months after treatment was withdrawn. In the other two patients, treatment was ineffective primarily and after 5 months. Our data confirm the usefulness of ketoconazole in the treatment of Cushing's disease, but they also show that primary resistance and tachyphylaxis in long-term treatment may occur, as previously reported.
authors.affiliation: Clinique Médicale et Endocrinologique, Hôpital de Brabois, Vandoeuvre-les-Nancy.
authors.forename: V
authors.initials: V
authors.lastname: Pascal
authors.forename: S
authors.initials: S
authors.lastname: Denet
authors.forename: G
authors.initials: G
authors.lastname: Weryha
authors.forename: P
authors.initials: P
authors.lastname: Kaminski
authors.forename: J
authors.initials: J
authors.lastname: Leclère
authors.forename: P
authors.initials: P
authors.lastname: Hartemann
mesh_terms: D000328:Adult; D000368:Aged; D003480:Cushing Syndrome / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007654:Ketoconazole
vernacular_title: Intérêt du kétoconazole dans le traitement de la maladie de Cushing.