Placental involvement in paracoccidioidomycosis.
A case of juvenile-type paracoccidioidomycosis in a pregnant woman is reported. The disease pre-dated pregnancy and antifungal treatment was being administered when she became pregnant. A premature male infant was delivered with no evidence of infection. Microscopic examination of the placenta showed numerous Paracoccidioides brasiliensis yeast forms in the intervillous space, enmeshed in a macrophagic-phagocytic reaction, with damage of the trophoblastic layer. Placental transfer of specific P. brasiliensis antibodies was demonstrated.
Blotta
M H
MH
Departamento de Patologia Clínica, Faculdade de Ciências Médicas da UNICAMP, Campinas, São Paulo, Brazil.
Altemani
A M
AM
Amaral
E
E
Silva
L J
LJ
Camargo
Z P
ZP
D000293:Adolescent; D000908:Antibodies, Fungal / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D007136:Immunoglobulins / Q000097:blood; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007958:Leukocyte Count; D008297:Male; D010229:Paracoccidioidomycosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D010920:Placenta / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D013601:T-Lymphocytes / Q000276:immunology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000908:Antibodies, Fungal; D015704:CD4 Antigens; D016827:CD8 Antigens; D007136:Immunoglobulins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination