[IR-spectroscopic study of the interaction of chromium salts with native DNA].
Infrared spectra of some unoriented films of DNA contained CrCl3, K2Cr2O7 and Cr2(SO4)3 have been obtained at relative humidities (r.h.) 0 to 93%. Chromium cations were shown to interact with phosphoric groups of DNA molecules. Cr2(SO4)3 or K2Cr2O7 content exceeds 0.1 Cr/P, the sugar-phosphate backbone of the double helix becomes irregular and nucleic bases unstacked, i.e. denaturation of DNA occurs. A very small amount of the salt, less than 0.01 Cr/P contained in DNA films prevents the conformational transition of the double helix from the B to A form induced by r.h. decreasing. The efficiency of the chromium salts in preventing the transition falls in the row: Cr2(SO4)3 > K2Cr2O7-CrCl3.
Montrel'
M M
MM
Shabarchina
L I
LI
Pletneva
T V
TV
Ershov
Iu A
IuA
D000818:Animals; D002712:Chlorides; D002857:Chromium / Q000737:chemistry*; D017608:Chromium Compounds; D004247:DNA / Q000737:chemistry*; D005399:Fishes; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D011192:Potassium Dichromate / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013431:Sulfates / Q000737:chemistry*
D002712:Chlorides; D017608:Chromium Compounds; D013431:Sulfates; D002857:Chromium; C040874:chromium sulfate; D004247:DNA; C017133:chromous chloride; D011192:Potassium Dichromate
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