title: Regional blood flow and oxygen transport in septic shock.
abstract: OBJECTIVE
  To measure the blood flow distribution and regional oxygen transport in hyperdynamic septic shock during hypotension and after correction by vasopressor doses of dopamine or norepinephrine.
  
  
  METHODS
  Prospective, randomized, controlled trial.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  Ten patients with hyperdynamic septic shock (ages ranging from 45.1 +/- 16.6 yrs) and a control group of 11 postoperative cardiac surgery patients (ages ranging from 54.8 +/- 7.9 yrs).
  
  
  METHODS
  Systemic and regional hemodynamics and oxygen transport were measured in ten patients with hyperdynamic septic shock during hypotension and after vasopressor therapy (norepinephrine or dopamine). Oxygen consumption (VO2) was measured by indirect calorimetry and splanchnic and leg blood flow with indocyanine green infusion.
  
  
  RESULTS
  Splanchnic blood flow and VO2 (p < .05) were increased in septic shock during hypotension and during vasopressor therapy. Both dopamine and norepinephrine increased systemic blood flow and VO2 independently of the arterial lactate level. Despite the relatively small changes in systemic oxygen transport, major regional changes occurred in oxygen delivery and VO2, and these changes were unpredictable from systemic changes.
  
  
  CONCLUSIONS
  Regional changes in oxygen transport in septic shock cannot be predicted from the changes in the whole body. The increased oxygen demand in the splanchnic region is the main risk factor for splanchnic tissue hypoxia in septic shock.
authors.affiliation: Department of Intensive Care, Kuopio University Hospital, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Ruokonen
authors.forename: J
authors.initials: J
authors.lastname: Takala
authors.forename: A
authors.initials: A
authors.lastname: Kari
authors.forename: H
authors.initials: H
authors.lastname: Saxén
authors.forename: J
authors.initials: J
authors.lastname: Mertsola
authors.forename: E J
authors.initials: EJ
authors.lastname: Hansen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002153:Calorimetry, Indirect; D001026:Coronary Artery Bypass; D004298:Dopamine / Q000494:pharmacology / Q000627:therapeutic use; D005263:Femoral Artery / Q000502:physiology*; D005268:Femoral Vein / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007208:Indocyanine Green; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects; D011446:Prospective Studies; D012039:Regional Blood Flow; D015657:Respiratory Transport; D012772:Shock, Septic / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology*; D013152:Splanchnic Circulation / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D007773:Lactates; D014409:Tumor Necrosis Factor-alpha; D019344:Lactic Acid; D007208:Indocyanine Green; D004298:Dopamine; D009638:Norepinephrine