Inhibiting effects of serotonin and serotonin antagonists on the migration of mononuclear leucocytes.
The effect of serotonin and the serotonin antagonists ketanserin, methiotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique. The migration of mononuclear leucocytes was inhibited by serotonin at 10(-4) and 10(-6)-10(-10)mol/l. An inhibition of the mononuclear leucocyte migration was also caused by ICS-205-930 at 10(-4)mol/l, ketanserin at 10(-4) and 10(-8)-10(-10)mol/l and methiotepine at 10(-4) and 10(-6)-10(-8)mol/l. No inhibiting effects of serotonin or the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration.
Bondesson
L
L
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Nordlind
K
K
Lidén
S
S
Sundström
E
E
D002465:Cell Movement / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology; D007650:Ketanserin / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000502:physiology; D008719:Methiothepin / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D000077526:Tropisetron
D007211:Indoles; D012702:Serotonin Antagonists; D012701:Serotonin; D008719:Methiothepin; D000077526:Tropisetron; D007650:Ketanserin