HLA-DPA1 and HLA-DPB1 in rheumatoid arthritis and its subsets.
The aim of this study was to examine the relationship between HLA-DP and susceptibility to articular and extra-articular features (Felty's syndrome and vasculitis) of rheumatoid arthritis (RA). The possible association of DP types with severity of articular disease was also analysed. No statistically significant associations were observed between HLA-DP alleles and articular or extra-articular features of RA, or to the severity of the arthritis when p was corrected for the number of alleles tested.
Hutchings
C J
CJ
University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford.
Hillarby
M C
MC
McMahon
M J
MJ
Ollier
W E
WE
Grennan
D M
DM
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D005258:Felty Syndrome / Q000235:genetics / Q000276:immunology*; D005787:Gene Frequency; D006682:HLA-DP Antigens / Q000235:genetics*; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D014657:Vasculitis / Q000235:genetics / Q000276:immunology*
D006682:HLA-DP Antigens; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; C071172:HLA-DPA1 antigen; C071170:HLA-DPB1 antigen