title: Evaluation of hemostatic function following Norplant implant removal.
abstract: Norplant implant use in Singapore showed a decrease in vitamin K-dependent Factors II, V, VII and reduction in fibrinolytic activity at the end of 5 years of use. Increased platelet numbers and accelerated platelet aggregation were also found throughout the 5 years of Norplant use. It thus appears that unlike the combined pill, prolonged Norplant use does not activate the coagulation system and does not enhance a state of hypercoagulation. On removal of the Norplant implants at the end of 5 years, the significant changes seen in hemostatic function observed with Norplant use remained.
authors.affiliation: Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: D F
authors.initials: DF
authors.lastname: Loke
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000032:analysis; D001792:Blood Platelets / Q000187:drug effects; D004343:Drug Implants; D005260:Female; D006400:Hematocrit; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D011517:Prothrombin Time; D012846:Singapore; D013375:Substance Withdrawal Syndrome; D013997:Time Factors; D014812:Vitamin K / Q000032:analysis
chemical_list: D001779:Blood Coagulation Factors; D004343:Drug Implants; D014812:Vitamin K; D016912:Levonorgestrel