title: Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
abstract: The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S. Here, we review a series of results which speak to the elements of RB structure which contribute to this activity. Included is its internal colinear protein receptor domain (i.e. the 'pocket').
authors.affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: D M
authors.initials: DM
authors.lastname: Livingston
authors.forename: W
authors.initials: W
authors.lastname: Kaelin
authors.forename: T
authors.initials: T
authors.lastname: Chittenden
authors.forename: X
authors.initials: X
authors.lastname: Qin
mesh_terms: D002455:Cell Division / Q000187:drug effects; D016193:G1 Phase; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D012516:Osteosarcoma; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000502:physiology*; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: D005839:Gentamicins; D011993:Recombinant Fusion Proteins; D016160:Retinoblastoma Protein; C010680:antibiotic G 418