title: Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.
abstract: Myelin/oligodendrocyte glycoprotein (MOG) is found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system, and it is a target antigen in experimental autoimmune encephalomyelitis and multiple sclerosis. We have isolated bovine, mouse, and rat MOG cDNA clones and shown that the developmental pattern of MOG expression in the rat central nervous system coincides with the late stages of myelination. The amino-terminal, extracellular domain of MOG has characteristics of an immunoglobulin variable domain and is 46% and 41% identical with the amino terminus of bovine butyrophilin (expressed in the lactating mammary gland) and B-G antigens of the chicken major histocompatibility complex (MHC), respectively; these proteins thus form a subset of the immunoglobulin superfamily. The homology between MOG and B-G extends beyond their structure and genetic mapping to their ability to induce strong antibody responses and has implications for the role of MOG in pathological, autoimmune conditions. We colocalized the MOG and BT genes to the human MHC on chromosome 6p21.3-p22. The mouse MOG gene was mapped to the homologous band C of chromosome 17, within the M region of the mouse MHC.
authors.affiliation: Centre National de la Recherche Scientifique Unité 1488, Université de Paris VI, France.
authors.forename: D
authors.initials: D
authors.lastname: Pham-Dinh
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: J L
authors.initials: JL
authors.lastname: Nussbaum
authors.forename: G
authors.initials: G
authors.lastname: Roussel
authors.forename: P
authors.initials: P
authors.lastname: Pontarotti
authors.forename: N
authors.initials: N
authors.lastname: Roeckel
authors.forename: I H
authors.initials: IH
authors.lastname: Mather
authors.forename: K
authors.initials: K
authors.lastname: Artzt
authors.forename: K F
authors.initials: KF
authors.lastname: Lindahl
authors.forename: A
authors.initials: A
authors.lastname: Dautigny
mesh_terms: D000375:Aging / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D002417:Cattle; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D005803:Genes, Immunoglobulin; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009185:Myelin Proteins; D009186:Myelin Sheath / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid
chemical_list: C571326:MOG protein, human; D008562:Membrane Glycoproteins; C571327:Mog protein, mouse; C571328:Mog protein, rat; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger