(+/-) isoprenaline revisited: adverse effects of sympathomimetics in asthma.
It is a matter of concern that regular, excessive use of contemporary sympathomimetics has been associated with morbidity and mortality from asthma. As a consequence, restrictions on sympathomimetic usage have recently been advocated in asthma management guidelines. he association between excessive use of inhaled (+/-)isoprenaline and an epidemic of asthma deaths in the 1960s provides a precedent; hence, we have reviewed the numerous clinical and experimental reports concerning (+/-) isoprenaline to provide insight into the present controversy.
Hansel
T T
TT
Swiss Institute of Allergy and Asthma Research (SIAF), Sandoz Pharma Ltd., Basel.
Schwarz
F
F
Villiger
B
B
Morley
J
J
D001249:Asthma / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007545:Isoproterenol / Q000009:adverse effects*; D017410:Practice Guidelines as Topic; D013566:Sympathomimetics / Q000009:adverse effects*; D016896:Treatment Outcome
D013566:Sympathomimetics; D007545:Isoproterenol