Lachnumon and lachnumol a, new metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. I. Producing organism, fermentation, isolation and biological activities.
Several chlorinated metabolites with nematicidal, antimicrobial, and cytotoxic activities were isolated from submerged cultures of the ascomycete Lachnum papyraceum. Three compounds were identified as (+)-mycorrhizin A (3), (+)-chloromycorrhizin A (4) and (+)-dechloromycorrhizin A (5). The occurrence of 5 as a natural product is new. Two compounds, lachnumon (1) and lachnumol A (2), were found to be new fungal metabolites with cytotoxic, nematicidal and antimicrobial activities.
Stadler
M
M
Universität Kaiserslautern, Lehrbereich Biotechnologie, Fed. Rep. Germany.
Anke
H
H
Arendholz
W R
WR
Hansske
F
F
Anders
U
U
Sterner
O
O
Bergquist
K E
KE
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification*; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003511:Cyclohexanols / Q000302:isolation & purification*; D003512:Cyclohexanones / Q000302:isolation & purification*; D004852:Epoxy Compounds / Q000302:isolation & purification*; D005285:Fermentation; D007939:Leukemia L1210; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000969:Antinematodal Agents; D003511:Cyclohexanols; D003512:Cyclohexanones; D004852:Epoxy Compounds; C082435:lachnumon; C082436:lachnumol A