title: Degeneration of skeletal and cardiac muscles in c-myb transgenic mice.
abstract: In order to reveal cellular processes sensitive to abnormal c-myb expression in vivo, transgenic mice were produced by introducing the c-myb nuclear proto-oncogene under the ubiquitous transcriptional regulatory unit of the cytoplasmic beta-actin gene. Expression of c-myb in thymus did not cause apparent abnormality, but the mice unexpectedly developed degenerative abnormalities in skeletal and cardiac muscles; this occurred predominantly in males. Expression of c-myb in skeletal muscle was correlated with an inflammation of muscle and was accompanied by vacuolar degeneration of muscle fibres, their regeneration, and lymphocyte infiltration. The identical pathological progression in cardiac muscle was associated with cardiomegaly.
authors.affiliation: Laboratories of Molecular Oncology, Institute of Physical and Chemical Research, (RIKEN), Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Furuta
authors.forename: S
authors.initials: S
authors.lastname: Aizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Suda
authors.forename: Y
authors.initials: Y
authors.lastname: Ikawa
authors.forename: H
authors.initials: H
authors.lastname: Nakasgoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Nishina
authors.forename: S
authors.initials: S
authors.lastname: Ishii
mesh_terms: D000199:Actins / Q000235:genetics; D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D004247:DNA; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009135:Muscular Diseases / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D020598:Proto-Oncogene Proteins c-myb; D013950:Thymus Gland / Q000473:pathology
chemical_list: D000199:Actins; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D004247:DNA; D011505:Protein-Tyrosine Kinases