title: Reproducibility of resting cerebral blood flow measurements with H2(15)O positron emission tomography in humans.
abstract: Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H2(15)O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean +/- SD) for the first (40.3 +/- 6.4) and second (39.3 +/- 6.5) measurements was not significantly different (mean % difference 2.3 +/- 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.
authors.affiliation: Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
authors.forename: E
authors.initials: E
authors.lastname: Matthew
authors.forename: P
authors.initials: P
authors.lastname: Andreason
authors.forename: R E
authors.initials: RE
authors.lastname: Carson
authors.forename: P
authors.initials: P
authors.lastname: Herscovitch
authors.forename: K
authors.initials: K
authors.lastname: Pettigrew
authors.forename: R
authors.initials: R
authors.lastname: Cohen
authors.forename: C
authors.initials: C
authors.lastname: King
authors.forename: C E
authors.initials: CE
authors.lastname: Johanson
authors.forename: S M
authors.initials: SM
authors.lastname: Paul
mesh_terms: D000328:Adult; D000339:Affect; D002560:Cerebrovascular Circulation; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D010104:Oxygen Radioisotopes; D012016:Reference Values; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D012146:Rest; D014055:Tomography, Emission-Computed; D014867:Water
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water