title: Effect of antihormones on endometrial receptors and protein secretion.
abstract: The antiestrogen tamoxifen and the antiprogestin RU 486 both interact with respective hormones at the receptor level, RU 486 as a pure antagonist which inhibits endometrial development, the downregulation of estrogen and progesterone receptors and the production of endometrial protein, such as PP14, during the secretory phase of the menstrual cycle. Tamoxifen, on the other hand, has both agonistic and antagonistic action.
authors.affiliation: Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Bygdeman
authors.forename: M L
authors.initials: ML
authors.lastname: Swahn
authors.forename: K
authors.initials: K
authors.lastname: Gemzell-Danielsson
authors.forename: P
authors.initials: P
authors.lastname: Svalander
mesh_terms: D004717:Endometrium / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D011960:Receptors, Estrogen / Q000187:drug effects; D011980:Receptors, Progesterone / Q000187:drug effects; D013629:Tamoxifen / Q000494:pharmacology*
chemical_list: D011506:Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013629:Tamoxifen; D015735:Mifepristone