Inhibition of lipid peroxidation by piperine during experimental inflammation in rats.
Carrageenin induced rat paw oedema shows a direct co-relationship with liver lipid peroxidation and not with kidney or brain. Pretreatment with piperine or oxyphenylbutazone reduced the liver lipid peroxidation, acid phosphatase and oedema induced by carrageenin. However, no such co-relationship was observed with treatment of these anti-inflammatory agents in control animals. It is, therefore, suggested that the inhibition of these liver enzymes is non specific in nature.
Dhuley
J N
JN
Laboratory of Pharmacology, Hindustan Antibiotics Ltd, Pimpri, Pune, India.
Raman
P H
PH
Mujumdar
A M
AM
Naik
S R
SR
D000470:Alkaloids; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D052117:Benzodioxoles; D002351:Carrageenan; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D051381:Rats
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D002351:Carrageenan; C008922:piperine