Microsatellite polymorphisms and the genetic linkage map of the human genome.
The use of simple sequence repeats as polymorphic genetic markers has significantly facilitated the construction of reference maps of the human chromosomes and the mapping of mendelian genetic diseases. These markers display major advantages over other systems, including restriction fragment length polymorphisms and satellites, but also have some limitations.
Weissenbach
J
J
Unitê de Génétique Moléculaire Humaine, CNRS URA 1445, Institut Pasteur, Paris, France.
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D004276:DNA, Satellite / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D004276:DNA, Satellite