title: [Response of superficial bladder carcinoma to prophylacit treatment with mitomycin-C versus interferon. Preliminary study].
abstract: The efficacy of two protocols for the prevention of relapse using Mitomycin-C and alpha-Interferon in 56 patients with surface bladder carcinoma (stages Ta-T1) treated with TUR was compared in a prospective study. Relapse percentages and rates, related to the tumours' presentation characteristics (single, multiple, primary, recurrent), as well as their systemic and local toxicity, were evaluated. The study of statistical significance is made using the squared-chi test, and it is completed with a Fisher's test for groups containing few elements for accuracy. The results show no statistical differences (log rank p = 0.313) between the two groups of endovesical therapy, both confirming to be effective as adjuvant therapy to TUR in surface bladder tumours.
authors.affiliation: Servicio de Urología, Hospital Regional Universitario Reina Sofía, Córdoba.
authors.forename: J C
authors.initials: JC
authors.lastname: Regueiro López
authors.forename: F R
authors.initials: FR
authors.lastname: Alvarez-Cienfuegos
authors.forename: M
authors.initials: M
authors.lastname: Leva Vallejo
authors.forename: R
authors.initials: R
authors.lastname: Prieto Castro
authors.forename: J A
authors.initials: JA
authors.lastname: Merchan García
authors.forename: J L
authors.initials: JL
authors.lastname: Saceda López
authors.forename: M J
authors.initials: MJ
authors.lastname: Requena Tapia
authors.forename: R L
authors.initials: RL
authors.lastname: López-Pardo
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control*; D009367:Neoplasm Staging; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D016898:Interferon-alpha; D016685:Mitomycin
vernacular_title: Respuesta en el carcinoma superficial de vejiga al tratamiento profiláctico con Mitomycin-C versus interferon. Estudio preliminar.