Bioactive and other sesquiterpenoids from Porella cordeana.
Bioassay-directed fractionation of the MeCOEt extract of Porella cordeana yielded drimenin [1] and aristolone [4], which were moderately toxic towards DNA-repair-deficient mutants of Saccharomyces cerevisiae. Three inactive sesquiterpenes, 7-ketoisodrimenin [2], 7-ketoisodrimenin-5-ene [3], and norpinguisanolide, were also obtained. Compounds 2 and 3 are new.
Harrigan
G G
GG
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
Ahmad
A
A
Baj
N
N
Glass
T E
TE
Gunatilaka
A A
AA
Kingston
D G
DG
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D012717:Sesquiterpenes