title: Ageing in the autonomic nervous system: a result of nerve-target interactions? A review.
abstract: There are few generalisations that can be made regarding the changes that occur in autonomic nerves during ageing. Old age has different effects, including loss of neurones, loss of axon branches and alterations in neurotransmitters and other intracellular features. However, these age-related events are associated with particular and often small groups of neurones and are frequently species specific. Changes occur at different periods during development and maturity without any obvious age-stage at which neurodegenerative changes come to predominate. Some of the observations regarding neuronal changes in old age can be interpreted as the result of altered interactions between neurones and their peripheral target tissues. Recent studies in my laboratory support this contention. The neurotrophic theory has been used to explain such interactions during early development and it seems possible that, for example, alterations in the access of neurones to target-derived growth factors may underlie some of the changes that have been observed in old age. Plasticity in the mature autonomic nervous system may also be governed by similar relationships between nerves and their target tissues.
authors.affiliation: Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: Cowen
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001341:Autonomic Nervous System / Q000254:growth & development / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D005725:Ganglia, Autonomic / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010641:Phenotype
chemical_list: D009414:Nerve Growth Factors