title: A pilot study using 99mTc to measure lead and platinum in the human kidney.
abstract: A pilot study has been conducted to investigate the hypothesis that the chemotherapeutic drug, cisplatinum, can mobilize skeletal lead. In vivo measurements of lead and platinum in the kidney of chemotherapy patients were performed with the technique of x-ray fluorescence, using 99mTc in a backscatter geometry. The results of the pilot study were inconclusive; the majority of patients exhibited no evidence of kidney lead at the level of system sensitivity, and negligible blood and urine lead levels.
authors.affiliation: Medical Physics Group, School of Physics and Space Research, University of Birmingham, England.
authors.forename: A C
authors.initials: AC
authors.lastname: Todd
authors.forename: D R
authors.initials: DR
authors.lastname: Chettle
authors.forename: M C
authors.initials: MC
authors.lastname: Scott
authors.forename: L J
authors.initials: LJ
authors.lastname: Somervaille
authors.forename: R A
authors.initials: RA
authors.lastname: Braithwaite
authors.forename: R P
authors.initials: RP
authors.lastname: Beaney
authors.forename: E J
authors.initials: EJ
authors.lastname: Buxton
mesh_terms: D002945:Cisplatin / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007668:Kidney / Q000737:chemistry* / Q000000981:diagnostic imaging; D007854:Lead / Q000032:analysis* / Q000097:blood / Q000652:urine; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D010865:Pilot Projects; D010984:Platinum / Q000032:analysis*; D011877:Radionuclide Imaging; D013052:Spectrometry, X-Ray Emission; D013667:Technetium
chemical_list: D007854:Lead; D010984:Platinum; D013667:Technetium; D002945:Cisplatin