Ondansetron in the treatment of intractable nausea associated with theophylline toxicity.
OBJECTIVE
To report the efficacy of ondansetron in the treatment of a patient poisoned with theophylline.


METHODS
A 36-year-old man who ingested 6 g of sustained-release theophylline.


METHODS
Ondansetron 8 mg intravenously after clinical failure of other antiemetics.


RESULTS
Subjective relief of nausea within minutes, enabling the patient to tolerate multiple doses of activated charcoal and whole bowel irrigation.


CONCLUSIONS
Ondansetron may offer an alternative to present antiemetic therapy in the poisoned patient.
Sage
T A
TA
Department of Pharmacy, Department of Veterans Affairs Medical Center, San Diego, CA.
Jones
W N
WN
Clark
R F
RF
D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D009325:Nausea / Q000188:drug therapy* / Q000209:etiology; D017294:Ondansetron / Q000627:therapeutic use*; D011041:Poisoning / Q000628:therapy; D013806:Theophylline / Q000008:administration & dosage / Q000506:poisoning*; D014839:Vomiting / Q000188:drug therapy / Q000209:etiology
D003692:Delayed-Action Preparations; D017294:Ondansetron; D013806:Theophylline