Multiple lentigines syndrome in a Nigerian family.
Three cases of the multiple lentigines syndrome are reported in a Nigerian family, involving a father and two of his children. The major abnormalities in this syndrome include: multiple lentigines, cardiac defects, genitourinary malformations, neurological deficits, growth retardation, cephalofacial dysmorphism and a family history consistent with an autosomal dominant mode of inheritance. We hereby report these cases in whom the main features are multiple lentigines, ocular hypertelorism, electrocardiographic defects and a pattern consistent with an autosomal dominant mode of inheritance.
Kubeyinje
E P
EP
Department of Medicine, University of Benin Teaching Hospital, Nigeria.
Onunu
A N
AN
Obasohan
A O
AO
D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology; D000328:Adult; D002648:Child; D004562:Electrocardiography; D005147:Facial Bones / Q000002:abnormalities; D005260:Female; D005799:Genes, Dominant; D006130:Growth Disorders / Q000150:complications / Q000151:congenital* / Q000235:genetics; D006319:Hearing Loss, Sensorineural / Q000151:congenital; D006330:Heart Defects, Congenital / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D006972:Hypertelorism / Q000150:complications* / Q000235:genetics / Q000473:pathology; D007911:Lentigo / Q000150:complications / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D008297:Male; D009549:Nigeria; D012008:Recurrence; D012874:Skin Diseases, Infectious / Q000209:etiology*; D012886:Skull / Q000002:abnormalities; D013577:Syndrome; D014564:Urogenital Abnormalities