title: A comparison of propofol with other injectable anaesthetics in a rat model for measuring cardiovascular parameters.
abstract: Prolonged, stable, non-recovery anaesthesia is required for the assessment of the effects of novel compounds on the cardiovascular system. A comparison of injectable anaesthetic agents and combinations (thiobarbital, fentanyl-fluanisone and midazolam, propofol, fentanyl-fluanisone and propofol, and alphaxalone/alphadolone) was made in laboratory rats and the following parameters assessed over 3 h: blood pressure, heart rate and rhythm, respiration rate and depth, analgesia, ease of induction and maintenance of anaesthesia. It was found that propofol, with fentanyl-fluanisone premedication, provided stress-free induction, easily controlled anaesthesia, good analgesia and muscle relaxation for surgery, for up to 3 h duration. Heart rate, blood pressure and respiration remained stable and within normal limits during this time. The other anaesthetics/combinations assessed did not rate as highly in these respects. Propofol, following fentanyl-fluanisone premedication, would appear to be a useful and safe anaesthetic for use in rodents, which avoids significant effects on heart rate or blood pressure.
authors.affiliation: Zeneca Central Toxicology Laboratory, Cheshire, UK.
authors.forename: A
authors.initials: A
authors.lastname: Brammer
authors.forename: C D
authors.initials: CD
authors.lastname: West
authors.forename: S L
authors.initials: SL
authors.lastname: Allen
mesh_terms: D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002090:Butyrophenones / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D011277:Pregnanediones / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D013874:Thiopental / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D002090:Butyrophenones; D011277:Pregnanediones; C005014:fluanisone; C006477:alphaxalone; C009457:thiobarbital; D010424:Pentobarbital; D013874:Thiopental; C033418:alphadolone; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol