title: Psychiatric manifestations of olivo-ponto-cerebellar atrophy and treatment with clozapine.
abstract: Patients with multiple system atrophy, a neurodegenerative disease entity, have a high incidence of associated mental disturbances such as a mood disorder with or without psychotic features. Treatment of the psychiatric symptoms, without compromising neurological status, is often complicated and unsuccessful. This article describes a patient with olivo-ponto-cerebellar atrophy and treatment-resistant psychotic depression whose psychiatric symptoms were successfully treated with clozapine without aggravating the neurological disabilities.
authors.affiliation: University Hospitals of Cleveland, Ohio.
authors.forename: M A
authors.initials: MA
authors.lastname: Parsa
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: C
authors.initials: C
authors.lastname: Dubrow
authors.forename: L F
authors.initials: LF
authors.lastname: Ramirez
authors.forename: H Y
authors.initials: HY
authors.lastname: Meltzer
mesh_terms: D003024:Clozapine / Q000627:therapeutic use*; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D009849:Olivopontocerebellar Atrophies / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D003024:Clozapine