Paradoxical bronchoconstriction with nebulized albuterol but not with terbutaline.
A 40-yr-old woman with severe chronic asthma complained that her regular nebulized albuterol was exacerbating her symptoms. Changing to regular nebulized terbutaline resulted in a marked improvement in her peak flow readings. Double-blind challenge with nebulized albuterol and terbutaline confirmed paradoxical bronchoconstriction with albuterol but not with terbutaline. This indicates that paradoxical bronchoconstriction to beta 2-agonists can be specific to the drug preparation used rather than a class effect, as has previously been suggested.
Finnerty
J P
JP
Faculty of Medicine, Southampton General Hospital, United Kingdom.
Howarth
P H
PH
D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D009330:Nebulizers and Vaporizers; D013726:Terbutaline / Q000008:administration & dosage / Q000627:therapeutic use*
D000336:Aerosols; D013726:Terbutaline; D000420:Albuterol