Proton MR and human cervical neoplasia: ex vivo spectroscopy allows distinction of invasive carcinoma of the cervix from carcinoma in situ and other preinvasive lesions.
The concept that high-resolution (8.5-T) hydrogen-1 magnetic resonance (MR) spectroscopy can be used as an adjunct to conventional histologic diagnosis of cervical neoplasia was investigated. Cervical biopsy specimens (n = 159) were examined with H-1 MR spectroscopy and the results compared with results of histopathologic analysis. A high-resolution lipid MR spectrum was observed in 39 of 40 invasive carcinomas, whereas the 119 preinvasive samples showed little or no lipid spectrum but were characterized by a strong unresolved resonance between 3.8 and 4.2 ppm. Peak ratios of the methylene/methyl and the unresolved/methylene resonances allowed accurate distinction between invasive and preinvasive epithelial malignancy (P < .0001). Since MR spectroscopic examination does not destroy the specimen, the specimens remained intact for further testing and histopathologic analysis. The authors conclude that H-1 MR spectroscopy can independently allow distinction between invasive and preinvasive lesions of the cervix and has the potential to assist in clinical management of cervical cancer.
Delikatny
E J
EJ
Membrane NMR Unit, University of Sydney, New South Wales, Australia.
Russell
P
P
Hunter
J C
JC
Hancock
R
R
Atkinson
K H
KH
van Haaften-Day
C
C
Mountford
C E
CE
D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology