Evaluation of bioavailability upon oral administration of phytonadione preparations in beagle dogs.
Bioavailability of phytonadione was investigated after oral administration to beagle dogs. The administrations of phytonadione in a surfactant solution (preparation a) and in an oleic acid solution (preparations b) greatly increased the bioavailability of phytonadione. The AUCs of preparations a and b were about 2.5 times larger than those of commercially available tablets A and C. This result well corresponded to the results of the dissolution test previously reported. The absorption of phytonadione from the gastro-intestinal tract was affected by food and the bioavailability was largely increased under non-fasted conditions. However, a large scatter was observed in the data, and it was found that the evaluation of the bioavailability of phytonadione preparations could not be done in non-fasted animals.
Tokumura
T
T
Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
Tsushima
Y
Y
Machida
Y
Y
Kayano
M
M
Nagai
T
T
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D005079:Excipients; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009829:Oleic Acids / Q000494:pharmacology; D012995:Solubility; D012996:Solutions; D013501:Surface-Active Agents / Q000494:pharmacology; D013607:Tablets; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000493:pharmacokinetics*
D005079:Excipients; D009829:Oleic Acids; D012996:Solutions; D013501:Surface-Active Agents; D013607:Tablets; D010837:Vitamin K 1