title: Tourniquet-related hypotension in venous stasis ulcer excision.
abstract: Extremity tourniquets are widely used to achieve bloodless dissection in the surgical field. Excision of venous stasis ulcers (VSU) is aided by tourniquet use because of large dilated veins associated with venous stasis disease. We present 3 patients with hypotensive shock occurring 10 to 15 minutes after tourniquet release after excision of venous stasis ulcers. All patients had long histories of venous stasis changes and two-thirds had prior histories of deep vein thromboses and pulmonary embolism. Mean tourniquet inflation time was 34 minutes and there were electrocardiographic changes in two-third of the patients. All patients responded rapidly to standard resuscitation measures and in all 3 postoperative testing for pulmonary embolus and myocardial infarction was negative. Wound cultures revealed no organisms in 1 patient, mixed Gram-positive cocci in another, and greater than 10(5) Serratia marcescens in the third patient. Although small decreases in blood pressure and blood pH, and increases in blood lactate, PcO2, and creatinine phosphokinase, are normally associated with the use of extremity tourniquets, hypotensive shock has not been reported. The combined effect of tourniquet ischemia and venous stasis changes may cause hypotensive shock by (1) an endotoxic bolus upon tourniquet release, (2) pulmonary microembolization of platelet, fibrin, and leukocyte aggregates causing vasoactive substance release, and (3) synergistic effects of platelet-activating factor, a known mediator of endotoxic shock. The untoward events noted in these patients may be prevented by (1) proximal to distal dissection of the ulcer with initial ligation of large veins, (2) pretreatment with steroids and/or platelet-activating factor antagonists, and/or (3) slow release of the tourniquet.
authors.affiliation: Division of Plastic, Reconstructive, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, NC.
authors.forename: D L
authors.initials: DL
authors.lastname: Feldman
authors.forename: M
authors.initials: M
authors.lastname: Wigod
authors.forename: W
authors.initials: W
authors.lastname: Barwick
authors.forename: L S
authors.initials: LS
authors.lastname: Levin
mesh_terms: D000328:Adult; D006801:Humans; D007022:Hypotension / Q000209:etiology*; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D012769:Shock / Q000209:etiology / Q000503:physiopathology; D014111:Tourniquets / Q000009:adverse effects*; D014647:Varicose Ulcer / Q000601:surgery*