In vivo kinetics of oxidatively modified HDL.
The kinetics of oxidatively modified high-density lipoprotein (HDL) in vivo were investigated. 125I-labeled oxidized (Ox) HDL and 131I-labeled native (N) HDL were injected simultaneously into control and WHHL rabbits. The fractional catabolic rates of 125I-labeled Ox-HDL were significantly greater than those of 131I-labeled N-HDL in both control (2.52 +/- 0.36/day vs 0.94 +/- 0.02/day) and WHHL rabbits (4.07/day vs 1.32/day). Oxidized HDL was catabolized faster than native HDL and was taken up primarily by the liver, spleen, and kidney.
Liu
R
R
Saku
K
K
Zhang
B
B
Hirata
K
K
Shiomi
M
M
Arakawa
K
K
D000818:Animals; D007668:Kidney / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits; D013154:Spleen / Q000378:metabolism
D008075:Lipoproteins, HDL