Inhibition of non-enzymatic lipid peroxidation by 'Essentiale' a drug enriched in phosphatidylcholine in ethanol-induced liver injury.
The effect of 'Essentiale'--a drug, now clinically listed in European countries in the treatment of liver diseases was examined in ethanol-induced liver injury in rats (free access to a 20% ethanol solution for 3 months). The antioxidant enzymes, SOD (superoxide dismutase), CAT (catalase), GSH-R (glutathione reductase), non-protein and total SH groups as well as TBA-rs contents were investigated. Following treatment, we found beneficial effects in SOD and CAT activities. The above enzyme activities were restored after a 3-month drug administration. Furthermore, 'Essentiale' treatment normalized TBA-rs levels in the liver. These effects have been briefly discussed.
Chwiecko
M
M
Department of Inorganic and Analytical Chemistry, Medical Academy, Bialystok, Poland.
Holownia
A
A
Bielawska
A
A
Farbiszewski
R
R
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008104:Liver Cirrhosis, Alcoholic / Q000201:enzymology*; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D010713:Phosphatidylcholines; C011246:essential 303 forte; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase