Immunosuppressive action of cyclophosphamide in mice: contribution of some factors to determination of strain differences.
Mechanisms of strain differences in susceptibility to cyclophosphamide (CP) has been investigated with BALB/c, DBA/2, CC57BR, and C57BL/6 mice. It was shown that the final immunosuppressive effects of CP is a result of a combination of such factors as the level of CP alkylating metabolites in the bloodstream and the sensitivity of the target cells to antiproliferative action of these metabolites. The importance of the immune status peculiarities has been discussed.
Pukhalsky
A L
AL
Laboratory of Immunogenetics, National Research Center of Medical Genetics, Moscow, Russia.
Toptygina
A P
AP
Viktorov
V V
VV
D000477:Alkylating Agents / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013045:Species Specificity
D000477:Alkylating Agents; D007166:Immunosuppressive Agents; C048341:mafosfamide; D003520:Cyclophosphamide