Iron(III) chloride injection increases nigral uric acid in guinea-pig.
The present study was carried out to determine if iron chloride (FeCl3) injections into the substantia nigra of guinea-pigs produced changes in nigro-striatal uric acid levels. Two-weeks following unilateral injection of FeCl3 (185 nmol Fe3+), ipsilateral uric acid levels were increased 176% over contralateral levels in the substantia nigra. No effect on striatal uric acid levels was observed. Iron chloride injection produced a 74% depletion of dopamine levels in the ipsilateral striatum. Ipsilateral/contralateral ratios were significantly decreased for striatal dopamine and significantly increased for nigral uric acid when compared with saline-injected controls. The results of this work indicate that FeCl3 injections into the substantia nigra of guinea-pigs produce a significant, localized increase in tissue uric acid levels two weeks after treatment.
Ward
V L
VL
Department of Chemistry, East Carolina School of Medicine, East Carolina University, Greenville, NC 27858.
McGinty
J F
JF
Church
W H
WH
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D002712:Chlorides; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D005290:Ferric Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D007267:Injections; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*; D014527:Uric Acid / Q000378:metabolism*
D002712:Chlorides; D005290:Ferric Compounds; D014527:Uric Acid; D001205:Ascorbic Acid; C024555:ferric chloride; D004298:Dopamine