Inhibitory effect of intraduodenal administration of somatostatin analogue SDZ CO 611 on rat pancreatic exocrine secretion.
The inhibitory effect of the intraduodenal administration of a new somatostatin analogue, SDZ CO 611 (SDZ), on pancreatic secretion was evaluated in the rat. The exocrine pancreas was stimulated by either intravenous infusion of both secretion (0.06 CU/kg/h) and cholecystokinin octapeptide (CCK-8) (0.03 microgram/kg/h) or intraduodenal infusion of oleic acid (0.25 mmol/h) or casein (200 mg/h). Intraduodenal administration of SDZ in three different doses, 0.5, 1.0, and 2.0 mg/kg/h, resulted in dose-related inhibition of pancreatic secretion, including juice volume, bicarbonate, and amylase, stimulated by exogenous secretin and CCK. Intraduodenal oleic acid- and casein-induced increases in pancreatic secretion in terms of juice volume, bicarbonate, and amylase were also significantly suppressed by intraduodenal administration of SDZ in a dose of 2.0 mg/kg/h. Moreover, SDZ (2.0 mg/kg/h) significantly inhibited basal pancreatic secretion. It is concluded that the intraduodenal administration of SDZ inhibits pancreatic secretion stimulated by exogenous secretin and CCK-8 in physiological doses and by intestinal nutrients in the rat.
Shiratori
K
K
Department of Medicine and Gastroenterology, Tokyo Women's Medical College, Japan.
Watanabe
S
S
Takeuchi
T
T
D000818:Animals; D001481:Basal Metabolism; D002364:Caseins / Q000494:pharmacology; D002766:Cholecystokinin / Q000502:physiology; D004386:Duodenum; D007263:Infusions, Parenteral; D008297:Male; D015282:Octreotide / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012633:Secretin / Q000502:physiology
D002364:Caseins; D009829:Oleic Acids; C082402:SDZ CO 611; D012633:Secretin; D019301:Oleic Acid; D002766:Cholecystokinin; D015282:Octreotide