Regulated expression of the major histocompatibility complex class I genes.
The major histocompatibility complex (MHC) class I gene products are known to play a fundamental role in foreign antigen presentation to the cellular immune system. Much attention has been directed to the study of MHC class I gene expression as a means to understanding the processes by which MHC class I-mediated immune responses are regulated. Two areas of considerable interest have emerged, including regulation at the levels of transcriptional control and antigenic peptide-induced transport of MHC class I molecules. With an emphasis on these major areas of research, we review recent developments on the molecular and biochemical mediators and events of MHC class I gene regulation.
Tatake
R J
RJ
Department of Pathology, University of Connecticut Health Center, Farmington 06030.
Zeff
R A
RA
D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
D015395:Histocompatibility Antigens Class I