IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.
IP-10 is a member of the -C-X-C-chemokine superfamily of proinflammatory cytokines whose secretion is induced by interferon gamma (IFN-gamma) and lipopolysaccharide (LPS). To date no function has been described for IP-10. We have genetically engineered tumor cells to secrete high levels of murine IP-10 and demonstrate that while IP-10 has no effect on the growth of these tumor cells in culture, it elicits a powerful host-mediated antitumor effect in vivo. The IP-10 antitumor response is T lymphocyte dependent, non-cell autonomous, and appears to be mediated by the recruitment of an inflammatory infiltrate composed of lymphocytes, neutrophils, and monocytes. These results document an important biologic property of IP-10 and raise the possibility that some of the T cell-directed effects of IFN-gamma and LPS may be mediated by this chemokine.
Luster
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AD
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
Leder
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P
D000818:Animals; D001483:Base Sequence; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D003001:Cloning, Molecular; D016207:Cytokines / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D066298:In Vitro Techniques; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000473:pathology; D008969:Molecular Sequence Data; D005810:Multigene Family; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014407:Tumor Cells, Cultured
D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D016207:Cytokines; D009838:Oligodeoxyribonucleotides