title: A new model to test platelet adhesion under dynamic conditions. Application to the evaluation of a titanium nitride coating.
abstract: In order to evaluate under dynamic circumstances the in vitro platelet adhesion induced by rigid materials such as ceramic coatings deposited on selected substrates, a new model simulating a tube has been designed. In vitro platelet adhesion was assessed with this new model: the material was titanium nitride (TiN) deposited on Ti6A14V (TA6V) titanium alloy by a physical vapor deposition (PVD) process. The results were compared to those obtained with complete titanium carbide (TiC) graphite tubes coated with TiN by a chemical vapor deposition (CVD) process. The difference observed (less than 25%) in favour of the new system, could be due to the better surface state of the construction materials of this system. In fact it is a systemic error. However TiN confirms its good performance as a blood-contacting biomaterial.
authors.affiliation: Laboratoire de Biophysique, Université de Bordeaux II, France.
authors.forename: I
authors.initials: I
authors.lastname: Dion
authors.forename: C
authors.initials: C
authors.lastname: Baquey
authors.forename: P
authors.initials: P
authors.lastname: Havlik
authors.forename: J R
authors.initials: JR
authors.lastname: Monties
mesh_terms: D000497:Alloys; D001672:Biocompatible Materials; D004577:Electron Probe Microanalysis; D006353:Heart-Assist Devices; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D014025:Titanium; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C031462:titanium alloy (TiAl6V4); C041500:titanium nitride; D014025:Titanium