In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic.
In in vitro susceptibility tests, the new penem CP-70,429 showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,429 was stable to various types of beta-lactamases except for the enzyme from X. maltophilia and was 16- to 128-fold more active than the other compounds against beta-lactamase-producing strains of Enterobacter cloacae and Citrobacter freundii.
Minamimura
M
M
Episome Institute, Gunma, Japan.
Taniyama
Y
Y
Inoue
E
E
Mitsuhashi
S
S
D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology*; D004355:Drug Stability; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000201:enzymology; D007769:Lactams; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000378:metabolism*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D007769:Lactams; D047090:beta-Lactams; C082897:sulopenem; D001618:beta-Lactamases