title: Chronic neuropsychological impairment resulting from disulfiram overdose.
abstract: The present case study examines the sequelae of disulfiram overdose and resulting chronic organic brain syndrome, with a 45-year-old, white, male alcoholic. Previous reports have discussed acute organic brain syndromes that are reversed after discontinuance of the drug. This particular case, however, resulted in significant cerebral impairment that was irreversible. Full neuropsychological testing which describes the extent of these neurologic deficits is presented, along with some possible reasons for these chronic sequelae.
authors.affiliation: Health Sciences Center, University of Virginia, Charlottesville 22908.
authors.forename: T V
authors.initials: TV
authors.lastname: Ryan
authors.forename: A D
authors.initials: AD
authors.lastname: Sciara
authors.forename: J T
authors.initials: JT
authors.lastname: Barth
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000437:Alcoholism / Q000534:rehabilitation*; D003072:Cognition Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D004221:Disulfiram / Q000506:poisoning* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D008318:Malpractice / Q000331:legislation & jurisprudence; D008508:Medication Errors; D008875:Middle Aged; D009483:Neuropsychological Tests; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology
chemical_list: D004221:Disulfiram