Rapid karyotyping in ectopic pregnancies.
The aim of this study was to determine the feasibility of karyotyping ectopic Fallopian tube pregnancies utilizing dividing cytotrophoblast cells. Villi from 78 ectopic conceptuses were processed by the direct chromosome technique and cytogenetic diagnosis was successful in 60 cases (76.9 per cent). The amount of villi obtained, as well as villus morphology, was correlated with cytogenetic success rate. Histological examination of the Fallopian tube was also carried out. A total of 47 cases were chromosomally abnormal (78.3 per cent), which is the highest frequency of cytogenetic abnormalities reported to date.
Cohen
D
D
Departamento de Genética Humana, Sanatorio de la Mujer, Rosario, Argentina.
Bragos
I
I
Berta
C
C
Fodor
M
M
Alonso
E
E
Nasio
C
C
Kreiman
L
L
Pineda
R
R
D015193:Chorionic Villi Sampling; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005187:Fallopian Tubes / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000235:genetics* / Q000473:pathology; D011296:Prenatal Diagnosis