title: [Transport of ions into human erythrocytes in various forms of hemolytic anemia: a correlation analysis].
abstract: The activity of Na+, K(+)-ATPase (ouabain-inhibited 86Rb influx), Na+, K+ cotransport (ouabain-insensitive furosemide-inhibited 86Rb or 22Na influx), Na+/Na+ exchange (ouabain-insensitive phloretin-inhibited 22Na influx) and Na+/Li+ exchange (ouabain-insensitive Na0(+)-depended Li+ efflux) as well as the passive permeability of the erythrocyte membrane for Na+, K+ and Li+ have been studied in patients with primary (microspherocytosis, hemoglobinopathy) and secondary (autoimmune) hemolytic anemia. The activities of the Na+, K(+)-pump and Na+, K(+)-cotransport were increased in patients with microspherocytosis-by 45% and 70%, respectively. In patients with hemoglobinopathy the Na+/Li+ exchange and passive permeability for K+ were increased 2-3-fold in comparison with the control with the control group. The increased passive permeability for K+ may partly be due to the increased K+, Cl(-)-cotransport. In patients with autoimmune anemia the 3-fold increase in the passive permeability for monovalent cations and the 2-fold increased activity of Na+, K+ cotransport were found. There was no significant correlation between the Na+/Na+ and Na+/Li+ exchange which suggests that the cellular mechanisms of activity control in those ion transport systems differ essentially. No correlation was found between the passive permeability for Na+ and K+ either. These data indicate that simple diffusion (leakage) is not the only pathway for the passive permeability of the erythrocyte membrane for monovalent cations.
authors.forename: S N
authors.initials: SN
authors.lastname: Orlov
authors.forename: N I
authors.initials: NI
authors.lastname: Pokudin
authors.forename: L S
authors.initials: LS
authors.lastname: El'-Rabi
authors.forename: V I
authors.initials: VI
authors.lastname: Brusovanik
authors.forename: A A
authors.initials: AA
authors.lastname: Kubatiev
mesh_terms: D000293:Adolescent; D000328:Adult; D000743:Anemia, Hemolytic / Q000378:metabolism*; D001692:Biological Transport; D002412:Cations; D002463:Cell Membrane Permeability; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002412:Cations
vernacular_title: Transport ionov v éritrotsitakh cheloveka pri razlichnykh formakh gemoliticheskoĭ anemii: korreliatsionnyĭ analiz.