[Effect of heparin on the interaction between platelets with collagen].
An effect of a standard heparin preparation on the interaction between blood platelets and collagen has been investigated. The experiments have shown, that the addition of heparin in the concentration of 0.3; 0.6 or 0.9 IU/mL did not change the interaction between blood platelets and collagen. Such interaction increased, when heparin concentration was 1,2 IU/mL, and remained unchanged despite the further increase in heparin concentration. The authors suggest that such a course of this interaction results from the stimulating action of heparin added in adequate concentration on protein release from platelet alpha granulations--which bound GP II b/III a complex with collagen.
Komarnicki
M
M
Kliniki Hematologii Instytutu Chorób Wewnetrznych AM.
Kaźmierczak
M
M
Krupa
D
D
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged
D006493:Heparin; D003094:Collagen
Wpływ heparyny na interakcje krwinek płytkowych z kolagenem.