title: Activities of two 9-deazaguanine analogue inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955, in vitro and in vivo.
authors.affiliation: Department of Immunopathology, Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Ann Arbor, Michigan 48105.
authors.forename: R B
authors.initials: RB
authors.lastname: Gilbertsen
authors.forename: M K
authors.initials: MK
authors.lastname: Dong
authors.forename: U
authors.initials: U
authors.lastname: Josyula
authors.forename: J C
authors.initials: JC
authors.lastname: Sircar
authors.forename: D J
authors.initials: DJ
authors.lastname: Wilburn
authors.forename: M C
authors.initials: MC
authors.lastname: Conroy
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003848:Deoxyguanine Nucleotides / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D013876:Thiophenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D003848:Deoxyguanine Nucleotides; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D013876:Thiophenes; C070377:CI 972; C076778:9-deaza-9-(3-thienylmethyl)guanine; D006147:Guanine; C029603:deoxyguanosine triphosphate; D011683:Purine-Nucleoside Phosphorylase