Comparative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections in children.
The relative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections was assessed in 2- to 9-year-old children living in two different Bolivian rural communities. Both agents were equally very effective (100% cure rate) in treating ascariasis. Albendazole was clearly more active than mebendazole against hookworm infections, both in terms of egg reduction rate (92.8% vs. 62.4%) and cure rate (81.8% vs. 17.2%). As far as trichuriasis is concerned, albendazole produced a higher egg reduction rate than mebendazole (45.7% vs 15%), but a lower cure rate (33.3% vs 60%). Both drugs were well tolerated.
Bartoloni
A
A
Cattedra di Malattie Infettive, Università di Firenze, Italy.
Guglielmetti
P
P
Cancrini
G
G
Gamboa
H
H
Roselli
M
M
Nicoletti
A
A
Paradisi
F
F
D000367:Age Factors; D015766:Albendazole / Q000008:administration & dosage* / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D001196:Ascariasis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D017164:Ascaris lumbricoides; D001838:Bolivia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000469:parasitology; D006725:Hookworm Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D006801:Humans; D008463:Mebendazole / Q000008:administration & dosage* / Q000627:therapeutic use; D010270:Parasite Egg Count; D015995:Prevalence; D012424:Rural Population; D016896:Treatment Outcome; D014257:Trichuriasis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology
D008463:Mebendazole; D015766:Albendazole