Peripheral esterases in the rat: effects of classical inducers.
Liver microsomal paraoxonase, aryl esterase and fluazifop butyl esterase (carboxylesterase) were induced by pretreatment of rat with phenobarbitone but not by beta-naphthoflavone or clofibric acid. In the extrahepatic tissues lung cytosolicfluazifop butyl and phenylacetate esterase were induced.
McCracken
N W
NW
Toxicology Unit, Medical School, Newcastle University, UK.
Blain
P G
PG
Williams
F M
FM
D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology*; D002995:Clofibric Acid / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D004950:Esterases / Q000096:biosynthesis* / Q000187:drug effects* / Q000378:metabolism; D006540:Herbicides / Q000378:metabolism / Q000493:pharmacokinetics; D006868:Hydrolysis; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008168:Lung / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010261:Paraoxon / Q000378:metabolism / Q000493:pharmacokinetics; D010634:Phenobarbital / Q000494:pharmacology*; D010648:Phenylacetates / Q000378:metabolism / Q000493:pharmacokinetics; D011725:Pyridines / Q000378:metabolism / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000201:enzymology; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D006540:Herbicides; D010648:Phenylacetates; D011725:Pyridines; C050585:fluazifop-butyl; D002995:Clofibric Acid; D019324:beta-Naphthoflavone; D004950:Esterases; C025136:phenylacetic acid; D010261:Paraoxon; D010634:Phenobarbital