[Expression and function of x-mla genes associated with leukemic transformation of cells].
Expression of genes, associated with leukemic transformation and called x-mla, was studied in cells of various types of experimental leukemia and in homologous normal cells. Augmentation of x-mla expression in malignant haemopoietic cells and lack or very low expression in normal tissues and non-haemopoietic tumors of mice and rats has been revealed. The involving of x-mla in proliferation control of leukemic but not normal cells has been shown. Product of x-mla--p46 was synthesized in cell-free translational system and purified. Its amino acid composition was determined and its mitogenic, RNAase activities, and ability to phosphorylation have been investigated.
Smirnova
I A
IA
Kishinskaia
E G
EG
Butenko
Z A
ZA
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002455:Cell Division / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002474:Cell-Free System; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D009363:Neoplasm Proteins / Q000096:biosynthesis; D010766:Phosphorylation; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012260:Ribonucleases / Q000378:metabolism
D000596:Amino Acids; D009363:Neoplasm Proteins; D012260:Ribonucleases
Issledovanie ékspressii i funktsiĭ genov x-mla, assotsiirovannykh s leĭkoznoĭ transformatsieĭ kletok.