[Metabolism in experimental chronic ischemic heart disease].
An increase in frequency of heart contractions, changes in the bioelectrical heart activity and decrease of the force-pump heart function are observed in the rabbits with model chronic ischemic heart disease lipid metabolism in significantly changed the concentration of cholesterol in the right ventricle myocardium as well as the concentrations of unsaturated lipid acids in the heart tissues increase, while the content of saturated lipid acids and antioxidant activity of plasma decrease. Bioenergetic processes change as follows: succinate-dehydrogenase and alpha-keto-glutarate-dehydrogenase activity decrease, while the concentrations of glycogen, lactic and pyruvic acids and lactate dehydrogenase activity in the heart tissues increase.
Bardov
V G
VG
Shmuter
G M
GM
Omel'chuk
S T
ST
Suchkov
B P
BP
Cherniavskaia
E N
EN
Uzhva
N F
NF
Maslenko
A A
AA
Ivanov
E V
EV
Anisimov
E N
EN
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D002908:Chronic Disease; D004195:Disease Models, Animal; D006003:Glycogen / Q000378:metabolism; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D050356:Lipid Metabolism; D009200:Myocardial Contraction / Q000502:physiology; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000378:metabolism*; D010084:Oxidation-Reduction; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism
D002791:Cholesterol, Dietary; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D006003:Glycogen; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase
Osobennosti metabolizma pri khronicheskoĭ ischemicheskoĭ bolezni serdtsa v éksperimente.