A case of Sjögren's syndrome complicating immune-mediated aplastic anaemia.
A 78-year-old Japanese woman with Sjögren's syndrome complicating immune-mediated aplastic anaemia is described. A diagnosis of aplastic anaemia was made from severe pancytopenia with hypoplastic marrow. Laboratory studies suggested an association of bone marrow suppressive T-lymphocytes with the pathogenesis of aplastic anaemia. Following the administration of mepithiostan and prednisolone, pancytopenia improved gradually. Two years after the onset of aplastic anaemia, Raynaud's phenomenon developed and examinations revealed the existence of keratoconjunctivitis sicca and anti-SSA/Ro and anti-SSB/La antibodies.
Satoh
M
M
Department of Internal Medicine, National Murayama Hospital, Tokyo, Japan.
Yamagata
H
H
Watanabe
F
F
Matsushita
Y
Y
Nakayama
S
S
Murakami
M
M
Matsuyama
J
J
Oshima
S
S
Akizuki
M
M
D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000150:complications*; D013601:T-Lymphocytes / Q000502:physiology