Spontaneous resolution of acquired factor X deficiency in amyloidosis.
We describe the case of a 51-year-old man with systemic amyloidosis in whom factor X activity was initially 6% of the normal. Amyloidosis was responsible for congestive heart failure and a nephrotic syndrome but there was no bleeding diathesis. A 12-month trial of melphalan and prednisone failed to improve cardiac and renal dysfunction; factor X levels remained low. Eighteen months after this treatment was stopped, factor X spontaneously normalized although renal insufficiency persisted. We suggest that the possibility of a spontaneous factor X recovery must be considered when evaluating efficacy of therapeutic agents in amyloidosis.
le Quellec
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Department of Internal Medicine A, Saint-Eloi Hospital, Montpellier, France.
Sotto
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Ciurana
A J
AJ
D000686:Amyloidosis / Q000150:complications*; D005171:Factor X Deficiency / Q000097:blood* / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous