Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique.
The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.
Anderson
H R
HR
Department of Ophthalmology, Queen's University of Belfast, UK.
Stitt
A W
AW
Gardiner
T A
TA
Lloyd
S J
SJ
Archer
D B
DB
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced*; D004195:Disease Models, Animal; D004285:Dogs; D005947:Glucose / Q000008:administration & dosage; D015203:Reproducibility of Results; D013311:Streptozocin; D013943:Thymol / Q000008:administration & dosage
D001786:Blood Glucose; C007905:Hartman's solution; D013943:Thymol; D013311:Streptozocin; D000496:Alloxan; D005947:Glucose