title: Sesquiterpene lactone contact sensitivity: clinical patterns of Compositae dermatitis and relationship to chronic actinic dermatitis.
abstract: A mix of 3 sesquiterpene lactones (SL) (SL mix 0.1%) was evaluated over a 4-year period. Of 7420 patients with eczema investigated by patch testing, 135 (68 male, 67 female) (1.8%) demonstrated positive reactions, 114 (84%) considered clinically relevant. Females outnumbered males until the age of 60, after which men were more commonly affected. The clinical patterns varied from patients presenting with generalized eczema (20%) or eczema of the hands and face (24%), to patients with hand (36%) or facial eczema (11%) alone. 48 patients were investigated for suspected photosensitivity and 29 (21 male, mean age 69 years, and 8 female, mean age 66 years) had abnormal cutaneous monochromatic irradiation tests. These results highlight the varied clinical presentation of SL contact dermatitis and its association with chronic actinic dermatitis. The SL mix proved reliable and safe, supporting its inclusion in the European standard series of contact allergens.
authors.affiliation: St John's Institute of Dermatology, St Thomas's Hospital, London, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Ross
authors.forename: H
authors.initials: H
authors.lastname: du Peloux Menagé
authors.forename: J L
authors.initials: JL
authors.lastname: Hawk
authors.forename: I R
authors.initials: IR
authors.lastname: White
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D017449:Dermatitis, Allergic Contact / Q000150:complications* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007783:Lactones / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000150:complications* / Q000473:pathology; D010944:Plants; D012717:Sesquiterpenes / Q000009:adverse effects*; D045787:Sesquiterpenes, Eudesmane
chemical_list: D007783:Lactones; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C083030:dehydrocostus lactone; C002602:costunolide; C004363:alantolactone