title: Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement--cutaneous presentation of Richter's syndrome.
abstract: The development of a large-cell non-Hodgkin's lymphoma in a patient suffering from chronic lymphocytic leukaemia is known as Richter's syndrome, representing one of the possible anaplastic transformations of the leukaemia. Cutaneous involvement is an extremely rare event. The case of a 45-year-old man with B-cell chronic lymphocytic leukaemia is reported. Five years later multiple cutaneous nodules developed on his extremities. Biopsies of the skin showed a diffuse large-cell lymphoma, bearing the same cell surface immunoglobulin light chain isotype as the leukaemia, suggesting the original relationship between both neoplasms.
authors.affiliation: Department of Dermatology, 12 de Octubre Hospital Medical School, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Zarco
authors.forename: J J
authors.initials: JJ
authors.lastname: Lahuerta-Palacios
authors.forename: L
authors.initials: L
authors.lastname: Borrego
authors.forename: R
authors.initials: R
authors.lastname: Toscano
authors.forename: R
authors.initials: R
authors.lastname: Gil
authors.forename: L
authors.initials: L
authors.lastname: Iglesias
mesh_terms: D000328:Adult; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000648:ultrastructure*; D013577:Syndrome