title: Hydantoin syndrome with holoprosencephaly: a possible rare teratogenic effect.
abstract: We report on a newborn girl with lobar holoprosencephaly and clinical signs of hydantoin syndrome. During pregnancy the mother was treated with diphenylhydantoin and primidon for psychomotor and petit mal seizures. The possible relationship between hydantoin syndrome, holoprosencephaly, and maternal intake of anticonvulsants during pregnancy is discussed.
authors.affiliation: Institute of Human Genetics, University of Erlangen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Kotzot
authors.forename: J
authors.initials: J
authors.lastname: Weigl
authors.forename: W
authors.initials: W
authors.lastname: Huk
authors.forename: H D
authors.initials: HD
authors.lastname: Rott
mesh_terms: D000014:Abnormalities, Drug-Induced; D005260:Female; D016142:Holoprosencephaly / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D010672:Phenytoin / Q000009:adverse effects*; D011859:Radiography; D013577:Syndrome
chemical_list: D010672:Phenytoin