Effects of testosterone on the development of endometrial tumors in female rats.
Long-term treatment of mature virgin female rats with a high dose of testosterone (24 weeks at a total dose of 300 mg) was associated with the development of endometrial adenomatous hyperplasia and resulted in a high incidence of adenocarcinoma when administered in combination with 7,12-dimethyl-benz[a]anthracene (DMBA; 2 mg in 0.1 ml sesame oil) introduced into the uterine cavity. Adenomatous hyperplasia occurred in all testosterone-treated rats, both with and without ovaries. Testosterone may promote the induction of endometrial tumors by DMBA.
Terada
S
S
Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Japan.
Suzuki
N
N
Uchide
K
K
Akasofu
K
K
Nishida
E
E
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D004714:Endometrial Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D013739:Testosterone; D015127:9,10-Dimethyl-1,2-benzanthracene