title: Prenatal detection of neuroblastoma: a ten-year experience from the Dana-Farber Cancer Institute and Children's Hospital.
abstract: OBJECTIVE
  To assess the relative frequency of, the clinical and pathological correlates in, and the prognosis of the subset of infants with neuroblastoma who were identified initially by prenatal ultrasonography.
  
  
  METHODS
  Retrospective review of all patients with neuroblastoma evaluated between 1982 and 1992.
  
  
  METHODS
  Large, urban, tertiary care children's hospital in Boston, Massachusetts.
  
  
  METHODS
  Eleven infants with neuroblastoma initially detected with prenatal sonograms were identified.
  
  
  RESULTS
  Nine patients had adrenal tumors; two had thoracic paraspinal tumors. Typical diagnostic evidence for neuroblastoma including a palpable abdominal mass and elevations in urinary catecholamines were not commonly seen postnatally. These patients had multiple favorable prognostic indicators including low stage of disease (10/11), favorable biological markers including cellular DNA content (5/5) and N-myc oncogene copy number (5/5), and histopathology suggestive for neuroblastoma in situ (7/11). All patients were treated by surgical resection. One patient exhibited progression of disease postoperatively, but demonstrated a complete clinical response to multiagent chemotherapy. Overall survival in our population was excellent with no deaths seen at a mean follow-up of 37 months (range 3 to 120 months).
  
  
  CONCLUSIONS
  Patients with neuroblastoma identified by prenatal ultrasonography generally, although not exclusively, follow a clinically favorable course in which surgical resection is curative. Chemotherapy is not indicated unless substantial progression of disease occurs.
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.
authors.forename: P T
authors.initials: PT
authors.lastname: Ho
authors.forename: J A
authors.initials: JA
authors.lastname: Estroff
authors.forename: H
authors.initials: H
authors.lastname: Kozakewich
authors.forename: R C
authors.initials: RC
authors.lastname: Shamberger
authors.forename: C W
authors.initials: CW
authors.lastname: Lillehei
authors.forename: H E
authors.initials: HE
authors.lastname: Grier
authors.forename: L
authors.initials: L
authors.lastname: Diller
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000151:congenital / Q000000981:diagnostic imaging* / Q000453:epidemiology; D001900:Boston / Q000453:epidemiology; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000151:congenital / Q000000981:diagnostic imaging* / Q000453:epidemiology; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016216:Ultrasonography, Prenatal