Effects of chronic treatment with phenazone on the hot-plate test and [3H]serotonin binding sites in pons and cortex membranes of the rat.
Many reports indicate that nonsteroidal anti-inflammatory drugs exert their antinociceptive effect through adrenergic and serotoninergic systems. We investigated the acute and chronic effects of phenazone on the pain threshold and on brain serotonin binding sites. A relationship between phenazone serum levels and the antinociceptive effect was found; acute treatment with phenazone provokes a significant decrease in serotonin binding sites both in the pons and cerebral cortex after 2, 4 and 8 h, but not after 24 h. After 15 and 30 days of treatment, the number of binding sites increases both in the pons and cortex.
Sandrini
M
M
Institute of Pharmacology, University of Modena, Italy.
Vitale
G
G
Pini
L A
LA
Sternieri
E
E
Bertolini
A
A
D000818:Animals; D000983:Antipyrine / Q000097:blood / Q000494:pharmacology*; D001665:Binding Sites; D002540:Cerebral Cortex / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000494:pharmacology; D017288:Pain Threshold / Q000187:drug effects*; D011149:Pons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*
D011985:Receptors, Serotonin; D009020:Morphine; D000983:Antipyrine