title: Investigation of a biodegradable, implantable antibiotic delivery system on rate of wound infection.
abstract: Biodel, a bioabsorbable polymer, may be adapted to serve as an antibiotic delivery system for high local concentrations of drugs. In an autocontaminated, irradiated wound model with a high intrinsic infection rate, implanted gentamicin-impregnated Biodel beads prevented wound infections in the submental area of rats.
authors.affiliation: Section of Plastic and Reconstructive Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.
authors.forename: M T
authors.initials: MT
authors.lastname: Sasmor
authors.forename: W D
authors.initials: WD
authors.lastname: Morain
authors.forename: L M
authors.initials: LM
authors.lastname: Balestrero
authors.forename: B J
authors.initials: BJ
authors.lastname: Camp
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D015169:Colony Count, Microbial; D004337:Drug Carriers; D004343:Drug Implants; D005839:Gentamicins / Q000008:administration & dosage*; D011108:Polymers; D011833:Radiation Injuries, Experimental / Q000382:microbiology; D051381:Rats; D014946:Wound Infection / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D004337:Drug Carriers; D004343:Drug Implants; D005839:Gentamicins; D011108:Polymers