title: One-day therapy for treatment of Helicobacter pylori infection.
abstract: The present study evaluated the effect of a one-day high-dose combined therapy on Helicobacter pylori infection. Thirty-two consecutive patients (suffering from either peptic ulcer or nonulcer dyspepsia) with Helicobacter pylori infection received omeprazole (40 mg) + bismuth subcitrate (240 mg x 4) + amoxicillin suspension (2000 mg x 4) + metronidazole (500 mg x 4), for only one day. Endoscopy, histology, culture, and susceptibility studies were done at entry and 30 and 90 days after the treatment day. Successful eradication was obtained in 23/32 (72%) patients and gastritis had resolved in 95% of these. Side effects were induced by the treatment in 6/32 (19%) patients, but these were all self-limiting, short-lasting, and did not require any specific treatment. Development of bacterial resistance to metronidazole occurred in 6/9 (67%) non-eradicated patients. These data suggest that one-day treatment with high doses of amoxicillin, metronidazole, bismuth, and omeprazole represents an effective, safe, and inexpensive therapeutic approach for the treatment of H. pylori infection.
authors.affiliation: Institute of Medical Clinic and Gastroenterology, Sant'Orsola Hospital, University of Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tucci
authors.forename: R
authors.initials: R
authors.lastname: Corinaldesi
authors.forename: V
authors.initials: V
authors.lastname: Stanghellini
authors.forename: G F
authors.initials: GF
authors.lastname: Paparo
authors.forename: S
authors.initials: S
authors.lastname: Gasperoni
authors.forename: G
authors.initials: G
authors.lastname: Biasco
authors.forename: O
authors.initials: O
authors.lastname: Varoli
authors.forename: M
authors.initials: M
authors.lastname: Ricci-Maccarini
authors.forename: L
authors.initials: L
authors.lastname: Barbara
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D002908:Chronic Disease; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage; D009942:Organometallic Compounds / Q000008:administration & dosage; D010437:Peptic Ulcer / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D008795:Metronidazole; D000658:Amoxicillin; C002791:bismuth tripotassium dicitrate; D009853:Omeprazole