Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum.
Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.
Mayerl
F
F
Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492.
Gao
Q
Q
Huang
S
S
Klohr
S E
SE
Matson
J A
JA
Gustavson
D R
DR
Pirnik
D M
DM
Berry
R L
RL
Fairchild
C
C
Rose
W C
WC
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D014334:Tropolone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; C082786:eupenifeldin; D014334:Tropolone