Cushing's disease presenting as pubertal arrest.
The clinical features of Cushing's disease in childhood are usually abnormal fat distribution, moon face, growth failure and hirsutism. Laboratory studies include evidence of cortisol and ACTH hypersecretion. This report concerns a boy who presented only with arrested puberty and growth failure as physical evidence of Cushing's syndrome and showed rapid progression of puberty once pituitary adenomas were removed.
Zadik
Z
Z
Pediatric Endocrine Unit, Kaplan Hospital, Rehovot, Israel.
Cooper
M
M
Chen
M
M
Stern
N
N
D000236:Adenoma / Q000601:surgery; D000293:Adolescent; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D003907:Dexamethasone; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006130:Growth Disorders / Q000209:etiology; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010911:Pituitary Neoplasms / Q000601:surgery; D011388:Prolactin / Q000097:blood; D011628:Puberty, Delayed / Q000209:etiology*
D007987:Gonadotropin-Releasing Hormone; D003907:Dexamethasone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D006854:Hydrocortisone