title: Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation.
abstract: The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.
authors.affiliation: Nippon Roche Research Center, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kamiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Itezono
authors.forename: T
authors.initials: T
authors.lastname: Umino
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: N
authors.initials: N
authors.lastname: Nakayama
authors.forename: K
authors.initials: K
authors.lastname: Yokose
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C082780:tetrafibricin