[Cyclophosphamide bolus therapy in lupus nephritis--status of the clinical study].
In order to establish a low-dose cumulative cyclophosphamide therapy for lupus nephritis, 21 patients were either randomized for at least 3 i.v. cyclophosphamide pulses until remission occurred or for 12 pulses. 18/21 patients developed a remission after an average of 7.3 pulses and a cumulative cyclophosphamide dose of 9.3 g. Side effects were only mild.
Witte
T
T
Abteilung für Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover.
Schaumann
D
D
Hein
R
R
Neumann
K H
KH
Koch
K M
KM
Deicher
H
H
Schmidt
R E
RE
D003520:Cyclophosphamide / Q000008:administration & dosage*; D006801:Humans; D008181:Lupus Nephritis / Q000188:drug therapy*
D003520:Cyclophosphamide
Cyclophosphamidbolus-Therapie bei Lupusnephritis--Stand der Therapiestudie.