title: Dosimetry of iodine-123 iomazenil in humans.
abstract: The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq.
authors.affiliation: Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: N P
authors.initials: NP
authors.lastname: Verhoeff
authors.forename: E
authors.initials: E
authors.lastname: Busemann Sokole
authors.forename: D
authors.initials: D
authors.lastname: Hengst
authors.forename: J B
authors.initials: JB
authors.lastname: Stubbs
authors.forename: E A
authors.initials: EA
authors.lastname: van Royen
mesh_terms: D000328:Adult; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging; D005442:Flumazenil / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011874:Radiometry; D011877:Radionuclide Imaging; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D005442:Flumazenil; C063038:iomazenil