Oral cornstarch therapy: is persorption harmless?
Sediments prepared from freshly voided urine of four patients with glycogenosis Ia, or leucine-sensitive hypoglycaemia, on oral cornstarch therapy contained starch granules, evidence for persorption i.e. the incorporation of undissolved starch particles. In these patients, amyluria was more marked than in untreated controls. While cornstarch therapy is successful and causes few side-effects, the possibility of late adverse reactions to persorbed starch should not be disregarded.
Gitzelmann
R
R
Department of Pediatrics, University of Zürich, Kinderspital, Switzerland.
Spycher
M A
MA
D000284:Administration, Oral; D000328:Adult; D002648:Child; D005260:Female; D005953:Glycogen Storage Disease Type I / Q000188:drug therapy* / Q000652:urine; D006801:Humans; D007003:Hypoglycemia / Q000188:drug therapy* / Q000652:urine; D007223:Infant; D008297:Male; D013213:Starch / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000652:urine
D013213:Starch