[Drugs involved in toxic epidermal necrolysis (Lyell's syndrome)].
Drug-induced toxic epidermal necrolysis (Lyell's syndrome) is a rare, potentially lethal disease that is characterized by the sudden necrosis of the epidermis and frequently associated with mucous and systemic involvement. Even though the etiology of the disease is probably multifactorial (including viral infections and anomalies of drug metabolism), its iatrogenic origin is the principally recognized cause. We have drawn up a substantial list of the culprit drugs showing their frequency of involvement in the syndrome.
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Service de Dermatopathologie et de Dermatologie, CHU du Sart Tilman, Liège, Belgique.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D004364:Pharmaceutical Preparations / Q000145:classification; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D013449:Sulfonamides / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D004364:Pharmaceutical Preparations; D013449:Sulfonamides
Les médicaments responsables de nécrolyse épidermique toxique (syndrome de Lyell).