Delayed matching-to-sample, object retrieval, and discrimination reversal deficits in chronic low dose MPTP-treated monkeys.
Cognitive deficits following chronic exposure to low doses of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were studied in monkeys asymptomatic for a gross parkinsonian motor disorder. Monkeys developed deficits in performance of delayed matching-to-sample, visual pattern discrimination reversal, and object retrieval tasks, all tasks that rely upon the integrity of the frontal-striatal axis. Performance on a visual pattern discrimination task, that relies primarily on inferotemporal cortex function, remained intact. These results extend previous findings of frontal-like cognitive deficits in MPTP-treated monkeys and further support the use of this model for studying the pathophysiology of the cognitive deficits associated with parkinsonism.
Schneider
J S
JS
Center for Neurological Research, Hahnemann University School of Medicine, Philadelphia, PA 19102.
Roeltgen
D P
DP
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003072:Cognition Disorders / Q000139:chemically induced* / Q000523:psychology; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008254:Macaca nemestrina; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009483:Neuropsychological Tests; D013997:Time Factors
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine