title: Simplified measurement of protein-bound iodine with epithermal neutron activation analysis.
abstract: A refined method for the measurement of protein-bound iodine (PBI) in blood serum was demonstrated by the use of epithermal neutron activation analysis (ENAA). PBI in ammonium sulfate-precipitated serum protein, after epithermal neutron activation, was determined by high resolution gamma-ray spectrometry. From our results, the PBI concentration was 67.8 +/- 2.2 ng/mL. Good agreement was obtained with published data, ranging from 40 to 80 ng/mL, which had been obtained using different analytical techniques. The validity of these techniques for PBI has been born out by a very good accuracy and simplicity without temperature dependence.
authors.affiliation: Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, Republic of China.
authors.forename: F I
authors.initials: FI
authors.lastname: Chou
authors.forename: H D
authors.initials: HD
authors.lastname: Lin
authors.forename: J C
authors.initials: JC
authors.lastname: Wei
authors.forename: A Y
authors.initials: AY
authors.lastname: Wang
authors.forename: J G
authors.initials: JG
authors.lastname: Lo
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002104:Cadmium; D006801:Humans; D007455:Iodine / Q000097:blood*; D009501:Neutron Activation Analysis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis
chemical_list: D001798:Blood Proteins; D002104:Cadmium; D007455:Iodine