title: Human brain fluoxetine concentrations.
abstract: Data on 22 subjects treated with fluoxetine suggest that magnetic resonance spectroscopy (MRS) of fluorine-19 can measure brain concentrations of fluoxetine/norfluoxetine in vivo. Fluoxetine accumulates in the human brain relative to plasma, with brain concentrations of fluoxetine/norfluoxetine ranging up to 10.7 micrograms/ml. Brain concentrations may reach a plateau between 6 and 8 months of treatment. The apparent concentration in brain relative to plasma is 20:1, roughly parallel to brain antidepressant concentration ratios in animal studies.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Arkansas for Medical Sciences, Little Rock.
authors.forename: C N
authors.initials: CN
authors.lastname: Karson
authors.forename: J E
authors.initials: JE
authors.lastname: Newton
authors.forename: R
authors.initials: R
authors.lastname: Livingston
authors.forename: J B
authors.initials: JB
authors.lastname: Jolly
authors.forename: T B
authors.initials: TB
authors.lastname: Cooper
authors.forename: J
authors.initials: J
authors.lastname: Sprigg
authors.forename: R A
authors.initials: RA
authors.lastname: Komoroski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D005473:Fluoxetine / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography
chemical_list: D005473:Fluoxetine