title: Effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats.
abstract: The effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats were studied. Following the administration of 2,5-dimethylpyrazine (100 mg/kg, s.c.) the weight of prostate and seminal vesicles, as well as testosterone levels in plasma were significantly decreased. One isomer of dimethylpyrazine, 2,6-dimethylpyrazine (100 mg/kg, s.c.), affected only the seminal vesicles, while 2,3-dimethylpyrazine had no influence on accessory reproductive organs. Following administration of 100 mg/kg of 2,5-dimethylpyrazine, acid phosphatase activity in the prostate and fructose content in the seminal vesicles were also significantly decreased compared with tissues from vehicle-treated animals. Weight of the testes and acid phosphatase activity therein were not affected following the administration of 2,5-dimethylpyrazine, nor were numbers of spermatozoa in the epididymis. These results showed that 2,5-dimethylpyrazine induced decrease in prostate and seminal vesicle weight by inhibiting testosterone uptake and reducing plasma testosterone levels.
authors.affiliation: Laboratory for Pharmaceutical Education, Tokyo College of Pharmacy, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Shimizu
authors.forename: A
authors.initials: A
authors.lastname: Ohta
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D004822:Epididymis / Q000187:drug effects / Q000201:enzymology; D005632:Fructose / Q000378:metabolism; D005837:Genitalia, Male / Q000187:drug effects*; D007536:Isomerism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects / Q000201:enzymology; D011506:Proteins / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000187:drug effects / Q000201:enzymology; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000201:enzymology; D013739:Testosterone / Q000097:blood
chemical_list: D011506:Proteins; D011719:Pyrazines; D005632:Fructose; D013739:Testosterone; D000135:Acid Phosphatase; C075524:2,5-dimethylpyrazine