Treatment of Crohn's disease recurrence after ileoanal anastomosis by azathioprine.
Ileoanal anastomosis is a surgical procedure performed in patients with ulcerative colitis. In a small number of patients operated on for ulcerative colitis, Crohn's disease occurs in the reservoir, mimicking pouchitis, and may lead to pouch excision and to a permanent terminal ileostomy. Two patients with recurrent Crohn's disease in the reservoir after ileoanal anastomosis were treated with azathioprine for 18 and 24 months, respectively. Azathioprine induced a complete clinical and endoscopic remission. These two observations suggested that immunosuppressive drugs were a good option for permanent ileostomy in cases of recurrence of Crohn's disease in the reservoir after ileoanal anastomosis.
Berrebi
W
W
Service d'Hepatogastroenterologie, Hôpital Cochin, Paris, France.
Chaussade
S
S
Bruhl
A L
AL
Pariente
A
A
Valleur
P
P
Hautefeuille
P
P
Couturier
D
D
D000293:Adolescent; D000328:Adult; D001003:Anal Canal / Q000601:surgery; D000714:Anastomosis, Surgical; D001379:Azathioprine / Q000627:therapeutic use*; D003424:Crohn Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D011184:Postoperative Period; D012008:Recurrence
D001379:Azathioprine