title: [New diagnostic and therapeutic aspects of hyper-IgE syndrome. Report of 3 cases].
abstract: Three female patients, 46, 34, and 19 years old, diagnosed of hyper-IgE syndrome are reported. The most relevant clinical findings are recurrent sinopulmonary tract infections, cold staphylococcal abscesses and chronic dermatitis. All patients presented elevated serum IgE levels (> 3,000 U/ml) and blood eosinophilia (> 0.6 x 10(9) cel/l). Two patients presented impaired antibody forming capacity to tetanus and pneumococcal antigens; one of these patients also had low serum IgG2 levels. After initiation of the intravenous gammaglobulin therapy, a marked improvement of infectious problems was observed. The controversial pathophysiology of this syndrome, the antibody deficiency present in some patients and the rationale for intravenous gammaglobulin therapy are discussed.
authors.affiliation: Sección de Inmunología, Hospital Son Dureta, Palma de Mallorca.
authors.forename: N
authors.initials: N
authors.lastname: Matamoros Florí
authors.forename: J
authors.initials: J
authors.lastname: Milá Llambí
authors.forename: M
authors.initials: M
authors.lastname: Hernández González
authors.forename: M R
authors.initials: MR
authors.lastname: Juliá Benique
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged
chemical_list: D016756:Immunoglobulins, Intravenous; D007073:Immunoglobulin E
vernacular_title: Nuevos aspectos diagnósticos y terapéuticos del síndrome de hiper-IgE. A propósito de 3 casos.