title: Replacement of the thoracic aorta with collagen-impregnated woven Dacron grafts. Early results.
abstract: We used the collagen-impregnated woven double-velour Dacron graft in 120 patients undergoing 122 aortic reconstructions. Seventy-nine aortic root, ascending, or arch replacements were performed during cardiopulmonary bypass with or without circulatory arrest; 53 of the 79 were for acute aortic dissection. In addition, three infants and one child underwent repair of truncus arteriosus. There were no deaths caused by hemorrhage or bleeding-related complications. For aortic root replacement, the impervious nature of the collagen-impregnated woven double velour Dacron graft allowed elimination of wrap-around techniques. Eight deaths occurred as a result of multisystem organ failure, which followed late diagnosis of type A dissection. Two patients underwent reoperation for late complications of type A dissection. Thirty-nine patients underwent treatment for disease of the descending aorta; eight of these patients underwent a central cannulation technique with profound hypothermic cardiopulmonary bypass. The other 31 underwent repair with aortic crossclamping without bypass. Four of these patients died: two as a result of multisystem organ failure, one as a result of uncontrolled bleeding from the native dissected aorta, and one as a result of intestinal necrosis. Follow-up studies for 2 months to 5 years revealed three late deaths caused by the rupture of a persistent aneurysmal false lumen after type A dissection. The intraoperative advantages of the collagen-impregnated woven double velour Dacron graft represent an important advance in vascular graft technology. Its handling and suturing characteristics are excellent, and the graft is completely impervious in its originally manufactured state. Needle holes self-seal rapidly. Medium-term follow-up by clinical, angiographic, computed tomographic, and magnetic resonance imaging techniques showed no late graft complications--specifically, no dilatation or thrombus formation.
authors.affiliation: Oxford Heart Centre, John Radcliffe Hospital, Headington, England.
authors.forename: S
authors.initials: S
authors.lastname: Westaby
authors.forename: A
authors.initials: A
authors.lastname: Parry
authors.forename: N
authors.initials: N
authors.lastname: Giannopoulos
authors.forename: R
authors.initials: R
authors.lastname: Pillai
mesh_terms: D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000601:surgery; D001013:Aorta, Thoracic / Q000293:injuries / Q000601:surgery*; D001014:Aortic Aneurysm / Q000601:surgery; D001807:Blood Vessel Prosthesis; D002648:Child; D003094:Collagen; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications / Q000401:mortality; D012086:Reoperation; D014338:Truncus Arteriosus / Q000601:surgery
chemical_list: D011093:Polyethylene Terephthalates; D003094:Collagen