Respinomycins A1, A2, B, C and D, a novel group of anthracycline antibiotics. II. Physico-chemical properties and structure elucidation.
Respinomycins A1, A2, B, C and D were revealed to be novel anthracycline antibiotics with molecular formulae of C51H72N2O20, C43H58N2O15, C35H43NO14, C36H45NO14 and C51H70N2O22, respectively. Their structures were determined by means of 1H-1H COSY, 13C-1H COSY and HMBC spectra. The structure of the aglycone of respinomycins was unambiguously determined by LSPD experiments and NOESY. The common skeleton of respinomycins is a new type and is distinguished from that of the nogalamycin group.
Ubukata
M
M
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Uzawa
J
J
Osada
H
H
Isono
K
K
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C072160:respinomycin A1; C082425:respinomycin A2; C082431:respinomycin B; C082432:respinomycin C; C082433:respinomycin D