Characterization of a new human bladder cancer cell line, UCRU-BL-28.
A new human bladder cancer cell line, UCRU-BL-28 has been established and characterized from a relapsed, cisplatin resistant, grade II, stage T4 tumor. This line is tumorigenic in nude mice and reflects the pathology of the original tumor. The morphology, the expression of tumor-associated antigens and EGF receptors, and the ability to grow both in an anchorage independent manner and in the absence of serum is explored. The BL-28 line has 71-74XXY chromosomes, with del 5q, der(9) and i(19q). Further studies on the molecular basis of bladder cancer, chemosensitivity to cisplatin, growth factor production and tissue invasion are under way.
Russell
P J
PJ
Kanematsu Laboratory, Royal Prince Alfred Hospital, New South Wales, Australia.
Palavidis
Z
Z
Rozinova
E
E
Philips
J
J
Wills
E J
EJ
Lukeis
R
R
Wass
J
J
Raghavan
D
D
D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D006801:Humans; D007621:Karyotyping; D011003:Ploidies; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor