Protein kinase inhibitors do not block the expression of established enhancement in identified Hermissenda B-photoreceptors.
One-trial conditioning of Hermissenda produces short- and long-term enhancement of generator potentials in identified type B-photoreceptors. The induction of short-term enhancement is blocked by kinase inhibitors and down-regulation of protein kinase C. We now report that established short- and long-term enhancement produced by one-trial conditioning is not reversed by the kinase inhibitors H-7 or sphingosine. These results indicate that persistent protein kinase C activity is not required in the maintenance or expression of enhancement.
Crow
T
T
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.
Forrester
J
J
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000818:Animals; D003214:Conditioning, Classical; D005071:Evoked Potentials / Q000187:drug effects; D007546:Isoquinolines / Q000494:pharmacology*; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013110:Sphingosine / Q000494:pharmacology*; D013997:Time Factors
D007546:Isoquinolines; D010879:Piperazines; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D011493:Protein Kinase C; D013110:Sphingosine