[The gastric anatomico-functional aspects (parietal cell mass, stimulated acid secretion and gastrinemia) in pernicious anemia].
We present here a study of parietal cell mass, stimulated acid secretion and basal gastrinemia both in the course of isolated chronic atrophic gastritis of the body-fundus and in chronic atrophic gastritis of the body-fundus associated with pernicious anemia. Analysis of our results evidences an overlapping cyto-secretory profile characterized by hypoparietalism with hypo-achlorhydria. The higher basal gastrinemia levels in pernicious anemia depend on the histological status of the antral mucosa--which was always normal in the patients with pernicious anemia--rather than any substantial morpho-functional differences of the body-fundus. We thus conclude that the term "atrophic gastritis" should be abolished, and that the term "chronic atrophic gastritis" be used to describe both conditions.
Testino
G
G
Divisione di Gastroenterologia ed Endoscopia Digestiva, Ospedale San Martino, Genova.
Menardo
G
G
Palombino
M A
MA
Cornaggia
M
M
De Iaco
F
F
Molinari
F
F
D000752:Anemia, Pernicious / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005748:Gastric Fundus; D005755:Gastrins / Q000097:blood*; D005757:Gastritis, Atrophic / Q000097:blood / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000473:pathology*; D010418:Pentagastrin; D013270:Stomach / Q000503:physiopathology*
D005755:Gastrins; D010418:Pentagastrin
Aspetti anatomo-funzionali gastrici (massa cellulare parietale, secrezione acida stimolata e gastrinemia) in corso di anemia perniciosa.