Application of microwave heating to the synthesis of [18F]fluoromisonidazole.
A modified synthesis of [18F]fluoromisonidazole is reported which makes use of microwave heating to reduce the synthesis time to ca 70 min from EOB. A remote system for column purification, concentration and delivery to an HPLC syringe, which reduces the total absorbed dose to the operator, is also described.
McCarthy
T J
TJ
Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110.
Dence
C S
CS
Welch
M J
MJ
D006361:Heating / Q000379:methods*; D008872:Microwaves; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C031843:fluoromisonidazole; D008920:Misonidazole