title: Pharmacokinetics of minocycline and vancomycin in rabbits.
abstract: The pharmacokinetic disposition of minocycline and vancomycin was studied in New Zealand White rabbits before initiating an experimental staphylococcal endocarditis protocol. Minocycline was administered in a multiple-dose regimen of 3 mg/kg i.v. every 12 h, 3 mg/kg i.v. every 8 h, and 6 mg/kg i.v. every 8 h. Vancomycin was given in a similar fashion using regimens of 75 mg/kg i.v. every 12 h and 50 mg/kg i.v. every 8 h. Multiple serum samples were obtained after the fifth dose and drug concentrations were analyzed by microbiologic assay. The pharmacokinetic parameters for each of the drug regimens were calculated using a two-compartment model by nonlinear least-squares regression. No statistically significant differences were noted in the volume of distribution or the half-life of the individual dosing regimens for either agent. As a result of this study, it appears that a minocycline regimen of 6 mg/kg i.v. every 8 h and a vancomycin regimen of 50 mg/kg i.v. every 8 h are appropriate dosing schemes for a comparative study of these agents in rabbits.
authors.affiliation: Department of Pharmacy, Hartford Hospital, CT 06115.
authors.forename: D P
authors.initials: DP
authors.lastname: Nicolau
authors.forename: C D
authors.initials: CD
authors.lastname: Freeman
authors.forename: C H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: R
authors.initials: R
authors.lastname: Quintiliani
mesh_terms: D000818:Animals; D005260:Female; D006207:Half-Life; D008911:Minocycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D014640:Vancomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D014640:Vancomycin; D008911:Minocycline