title: Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: a longitudinal evaluation.
abstract: A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.
authors.affiliation: Laboratory of Neurosciences, National Institute on Aging, NIH, Bethesda, MD 20892.
authors.forename: P
authors.initials: P
authors.lastname: Pietrini
authors.forename: N P
authors.initials: NP
authors.lastname: Azari
authors.forename: C L
authors.initials: CL
authors.lastname: Grady
authors.forename: J A
authors.initials: JA
authors.lastname: Salerno
authors.forename: A
authors.initials: A
authors.lastname: Gonzales-Aviles
authors.forename: L L
authors.initials: LL
authors.lastname: Heston
authors.forename: K D
authors.initials: KD
authors.lastname: Pettigrew
authors.forename: B
authors.initials: B
authors.lastname: Horwitz
authors.forename: J V
authors.initials: JV
authors.lastname: Haxby
authors.forename: M B
authors.initials: MB
authors.lastname: Schapiro
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism* / Q000523:psychology; D000647:Amnesia / Q000378:metabolism* / Q000523:psychology; D001923:Brain Chemistry / Q000502:physiology*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D012307:Risk Factors; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose