Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis.
Picroliv showed a dose (3-12 mg/kg, po for 7 days) dependent choleretic activity as evidenced by increase in bile flow and its contents (bile salts and bile acids). Significant anticholestatic activity was also observed against carbon tetrachloride induced cholestasis in conscious rat, anaesthetized guinea pig and cat. Picroliv was more active than the known hepatoprotective drug silymarin.
Saraswat
B
B
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Division of Pharmacology, Lucknow, India.
Visen
P K
PK
Patnaik
G K
GK
Dhawan
B N
BN
D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis; D002251:Carbon Tetrachloride; D002415:Cats; D002779:Cholestasis / Q000517:prevention & control*; D002934:Cinnamates / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use; D014641:Vanillic Acid / Q000627:therapeutic use*
D001647:Bile Acids and Salts; D002934:Cinnamates; D006027:Glycosides; D010936:Plant Extracts; D012838:Silymarin; C057463:kutkin; D002251:Carbon Tetrachloride; D014641:Vanillic Acid