Cobalt-mesoporphyrin inhibits heme oxygenase activity but it does not induce lipid peroxidation in rat brain membranes during photoirradiation.
We examined the effects of cobalt-mesoporphyrin (CoMP) in vitro. The porphyrin inhibited the activity of rat splenic heme oxygenase but scarcely stimulated peroxidation of lipids in a membrane fraction from rat brain during photoirradiation. The apparent inhibition constant for CoMP was 344 nM. It is suggested that CoMP may be a promising candidate for a chemopreventive of neonatal hyperbilirubinemia that is not associated with phototoxicity.
Keino
H
H
Department of Perinatology, Institute for Developmental Research, Aichi, Japan.
Banno
T
T
Mimura
S
S
Kashiwamata
S
S
D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000528:radiation effects* / Q000648:ultrastructure; D002462:Cell Membrane / Q000201:enzymology / Q000528:radiation effects / Q000648:ultrastructure; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors* / Q000502:physiology; D006932:Hyperbilirubinemia / Q000378:metabolism / Q000517:prevention & control; D008027:Light; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D008652:Mesoporphyrins / Q000494:pharmacology* / Q000627:therapeutic use; D008665:Metalloporphyrins / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013347:Subcellular Fractions
D008652:Mesoporphyrins; D008665:Metalloporphyrins; D006419:Heme Oxygenase (Decyclizing)