title: Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
authors.affiliation: Syntex Discovery Research, Palo Alto, California 94304.
authors.forename: K A
authors.initials: KA
authors.lastname: Walker
authors.forename: D J
authors.initials: DJ
authors.lastname: Kertesz
authors.forename: D M
authors.initials: DM
authors.lastname: Rotstein
authors.forename: D C
authors.initials: DC
authors.lastname: Swinney
authors.forename: P W
authors.initials: PW
authors.lastname: Berry
authors.forename: O Y
authors.initials: OY
authors.lastname: So
authors.forename: A S
authors.initials: AS
authors.lastname: Webb
authors.forename: D M
authors.initials: DM
authors.lastname: Watson
authors.forename: A Y
authors.initials: AY
authors.lastname: Mak
authors.forename: P M
authors.initials: PM
authors.lastname: Burton
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D051381:Rats; D013237:Stereoisomerism; D058886:Sterol 14-Demethylase; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000814:Aniline Compounds; D000924:Anticholesteremic Agents; C548418:CYP51A1 protein, human; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D013440:Sulfides; C082410:azalanstat; D002784:Cholesterol; D010088:Oxidoreductases; D058886:Sterol 14-Demethylase