title: [Effect of vitamin C on prostatilen mutagenicity in mice].
abstract: Frequencies of sperm head anomalies (SHA) and chromosome aberrations (CA) in bone marrow cells were studied after injection of drugs, prostatilen and vitamin C into the male mice Mus musculus. It was found that prostatilen (5, 10 and 50 mkg) increased the frequency of both SHA and CA. Vitamin C (14 and 140 mkg) induced no CA but increased SHA frequency at the dose of 140 mkg. The joint action of the drugs led to decrease in SHA frequency for all dose combinations. Antimutagenic action of vitamin C in the CA test was recorded for only 14 mkg dose.
authors.forename: V P
authors.initials: VP
authors.lastname: Bolonina
authors.forename: V S
authors.initials: VS
authors.lastname: Mikheev
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D008297:Male; D051379:Mice; D010455:Peptides / Q000037:antagonists & inhibitors*; D013077:Sperm Head / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D010455:Peptides; C069549:prostatilen; D001205:Ascorbic Acid
vernacular_title: Effekt vitamina C na mutagennost' prostatilena u mysheĭ.