title: Trifluoperazine inhibition of insulin-induced increase in skeletal muscle glucose uptake.
abstract: The ability of trifluoperazine, a calmodulin blocker, to prevent increases in skeletal muscle glucose uptake induced by insulin was tested. Insulin significantly increased glucose uptake by the rat hindlimb and trifluoperazine (10(-6) M) completely inhibited this increase. We conclude that calmodulin is a factor involved in the regulation of insulin-mediated glucose transport in muscle cells.
authors.affiliation: Departamento de Fisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
authors.forename: V
authors.initials: V
authors.lastname: Guarner
authors.forename: E H
authors.initials: EH
authors.lastname: Hernández
authors.forename: R
authors.initials: R
authors.lastname: Huerto
authors.forename: P
authors.initials: P
authors.lastname: Gorostiza
authors.forename: F
authors.initials: F
authors.lastname: Valenzuela
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002147:Calmodulin / Q000037:antagonists & inhibitors; D005947:Glucose / Q000378:metabolism*; D006614:Hindlimb / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007329:Insulin Antagonists / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014268:Trifluoperazine / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D002147:Calmodulin; D007328:Insulin; D007329:Insulin Antagonists; D014268:Trifluoperazine; D005947:Glucose