L-deprenyl increases GFAP immunoreactivity selectively in activated astrocytes in rat brain.
L-deprenyl is a selective inhibitor of monoamine oxidase (MAO) B, an enzyme predominantly localized in astrocytes. We have investigated the effect of treatment with L-deprenyl (0.25 mg kg-1 day-1) on glial fibrillary acidic protein (GFAP) immunoreactivity (IR) after lesioning the rat striatum with an injection cannula. No effect of drug treatment on GFAP IR was found in unlesioned striata. A significant increase (p < 0.01 vs saline treated rats) in GFAP IR was found in the tissue surrounding the lesion in striata of rats treated with L-deprenyl for 4 days after the lesion. When post-treated for 42 days, however, L-deprenyl no longer increased GFAP IR although reactive astrocytes were still present in the lesioned area. These results suggest that L-deprenyl can enhance the activation of astrocytes during a critical time-period following a striatal injury.
Biagini
G
G
Department of Human Physiology, University of Modena, Italy.
Zoli
M
M
Fuxe
K
K
Agnati
L F
LF
D000818:Animals; D001253:Astrocytes / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D001921:Brain / Q000166:cytology; D003342:Corpus Striatum / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012642:Selegiline / Q000494:pharmacology*
D005904:Glial Fibrillary Acidic Protein; D012642:Selegiline; D008995:Monoamine Oxidase