Urinary levels of IL-6 in patients with active lupus nephritis.
Using the IL-6 dependent hybridoma, MH60.BSF2, we measured urinary levels of interleukin 6 (IL-6) in 29 patients with active lupus nephritis. We detected IL-6 activity in the urine of 24 (83%) of 29 patients before the initiation of therapy. The median value of urinary IL-6 levels in patients with a histologic diagnosis of WHO class IV on renal biopsy was significantly higher than that in patients with other classes (p < 0.01). After treatment, urinary levels of IL-6 decreased significantly (p < 0.001). These data suggest that urinary levels of IL-6 may be a valuable tool for monitoring the progression of lupus nephritis.
Iwano
M
M
First Department of Internal Medicine, Nara Medical University, Japan.
Dohi
K
K
Hirata
E
E
Kurumatani
N
N
Horii
Y
Y
Shiiki
H
H
Fukatsu
A
A
Matsuda
T
T
Hirano
T
T
Kishimoto
T
T
D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000652:urine*; D007668:Kidney / Q000473:pathology; D008181:Lupus Nephritis / Q000188:drug therapy / Q000473:pathology / Q000652:urine*; D008297:Male; D013997:Time Factors
D015415:Biomarkers; D015850:Interleukin-6