Methylflavonolamine protects aorta from atherosclerosis in cholesterol-fed rabbits.
The effect of methylflavonolamine [4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)-flavone hydrochloride, MFA], synthesized recently by the Shanghai Institute of Pharmaceutical Industry, on the development of atherosclerosis was studied in male New Zealand white rabbits fed cholesterol for 10 wk. MFA, 7 mg.kg-1 daily ip, did not significantly alter the serum total cholesterol, HDL, and triglyceride levels, but significantly lowered the aortic cholesterol and calcium contents. Atheromatous lesions covered 53.3 +/- 11.8% of the intimal surface of the aorta in the saline group and 11.3 +/- 2.3% in the MFA group (P < 0.01). We conclude that MFA suppresses cholesterol-induced atherosclerosis.
Zhang
M S
MS
Department of Pharmacology, Shanxi Medical College, Taiyuan, China.
Zhou
E F
EF
Wang
M Z
MZ
Li
X M
XM
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002118:Calcium / Q000097:blood; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D044948:Flavonols; D008297:Male; D011817:Rabbits
D002121:Calcium Channel Blockers; D002791:Cholesterol, Dietary; D005419:Flavonoids; D044948:Flavonols; C052073:SIPI 549; D002784:Cholesterol; D002118:Calcium