title: A microsatellite-based index map of human chromosome 11.
abstract: We have constructed a continuous index map of 25 microsatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygosities of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 10(5):1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the index map with the cytogenetic map. The map will facilitate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.
authors.affiliation: Oregon Health Sciences University, Portland 97201.
authors.forename: M
authors.initials: M
authors.lastname: Litt
authors.forename: P
authors.initials: P
authors.lastname: Kramer
authors.forename: X Y
authors.initials: XY
authors.lastname: Hauge
authors.forename: J L
authors.initials: JL
authors.lastname: Weber
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: P J
authors.initials: PJ
authors.lastname: Wilkie
authors.forename: M S
authors.initials: MS
authors.lastname: Holt
authors.forename: S
authors.initials: S
authors.lastname: Mishra
authors.forename: H
authors.initials: H
authors.lastname: Donis-Keller
authors.forename: L
authors.initials: L
authors.lastname: Warnich
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004276:DNA, Satellite / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers