Study of cyclosporin A blood level during the early post-liver-transplantation period.
Correlations between acute rejection rate, cyclosporin A(CsA) blood level and CsA dose were studied in a group of 58 patients for 1 month following liver transplant. Therapy included prednisolone, azathioprine and CsA administered by continuous IV infusion. Blood CsA levels were measured by high performance liquid chromatography. No patient required renal dialysis. An acute rejection episode was recorded in 24 patients (group 1) between days 4 and 28 (mean 8 days), while 34 patients (group 2) showed no signs of rejection. A significant difference was observed (p < 0.05) between blood CsA levels (mean +/- SEM over the 6 days preceding the rejection episode in group 1 patients, and the first 6 postoperative days in group 2 patients (101 +/- 7 vs 121 +/- 5 ng/ml). The mean daily dose of CsA calculated over the same time period was significantly lower (p < 0.001) in group 1 patients (46 +/- 2 vs 60 +/- 2 mg/day). In addition, over the 8 days following surgery, only 54% of patients in group 1 attained a mean blood CsA level of a least 100 ng/ml, compared to 94% in group 2.
Masini
J P
JP
Département d'Anesthésie-Réanimation, Hôpital Saint-Antoine, Paris.
Poirier
J M
JM
Weissenburger
J
J
Desnault
H
H
Hannoun
L
L
Balladur
P
P
Nordlinger
B
B
Parc
R
R
Lienhart
A
A
Cheymol
G
G
D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
D016572:Cyclosporine