[Association between fibrinogen and blood sedimentation rate in combined extracorporal and fibrinogen reducing drug therapy].
Fibrinogen appears to play an important role in atherogenesis, whereby high levels of fibrinogen can lead to a disturbance of the haemorheologic pattern. To evaluate the association between fibrinogen and blood sedimentation rate (BSR) 40 patients suffering from cerebral multi-infarct disease underwent a single heparin-induced extracorporeal LDL < fibrinogen > precipitation (HELP). Subsequently they were randomly assigned to two groups, either receiving sustained-release bezafibrate 400 mg daily (n = 21) or placebo (n = 19) over a period of eight weeks. HELP led to a statistically significant reduction of fibrinogen (p < 0.0001). At the end of the trial the difference between the bezafibrate group and the controls became significant (p < 0.05). The BSR strictly followed the course of fibrinogen, indicating a significant reduction after HELP (p < 0.0001 for both BSR values) and a difference between both groups at the end of the study (p < 0.05 and p < 0.03, respectively). The correlation between fibrinogen and BSR remained significant during the whole trial.
Walzl
M
M
Universitätsklinik für Neurologie, Graz.
Walzl
B
B
Schied
G
G
Lechner
H
H
D000368:Aged; D001629:Bezafibrate / Q000008:administration & dosage* / Q000009:adverse effects; D001781:Blood Component Removal; D001799:Blood Sedimentation / Q000187:drug effects*; D002544:Cerebral Infarction / Q000097:blood / Q000628:therapy*; D003131:Combined Modality Therapy; D015161:Dementia, Multi-Infarct / Q000097:blood / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008077:Lipoproteins, LDL; D005340:Fibrinogen; D001629:Bezafibrate
Die Assoziation zwischen Fibrinogen und Blutsenkungs-Geschwindigkeit bei kombinierter extrakorporaler und medikamentöser fibrinogensenkender Therapie.