Effects of oral rinsing with triclosan and sodium lauryl sulfate on dental plaque formation: a pilot study.
Mouthwashes containing 0.3% or 0.15% triclosan in combination with 1.5% sodium lauryl sulfate (SLS) produced a significant reduction in plaque formation in a test panel of 11 students who refrained from oral hygiene during the test periods, during which they rinsed twice daily with different mouthwashes. Pl.I. was evaluated after each test period. A mouthwash containing only 1.5% SLS inhibited plaque to almost the same degree. In both cases, the major effect was on the buccal/lingual surfaces, where score 2 was changed to score 0. Addition of triclosan appeared to reduce the untoward side-effects of mouth-washes containing SLS alone (i.e. desquamation and a burning sensation in the mouth).
Waaler
S M
SM
Dental Faculty, University of Oslo, Norway.
Rölla
G
G
Skjörland
K K
KK
Ogaard
B
B
D000328:Adult; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D009067:Mouthwashes / Q000627:therapeutic use*; D010865:Pilot Projects; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
D009067:Mouthwashes; D012967:Sodium Dodecyl Sulfate; D014260:Triclosan