Investigation of a biodegradable, implantable antibiotic delivery system on rate of wound infection.
Biodel, a bioabsorbable polymer, may be adapted to serve as an antibiotic delivery system for high local concentrations of drugs. In an autocontaminated, irradiated wound model with a high intrinsic infection rate, implanted gentamicin-impregnated Biodel beads prevented wound infections in the submental area of rats.
Sasmor
M T
MT
Section of Plastic and Reconstructive Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.
Morain
W D
WD
Balestrero
L M
LM
Camp
B J
BJ
D000818:Animals; D001673:Biodegradation, Environmental; D015169:Colony Count, Microbial; D004337:Drug Carriers; D004343:Drug Implants; D005839:Gentamicins / Q000008:administration & dosage*; D011108:Polymers; D011833:Radiation Injuries, Experimental / Q000382:microbiology; D051381:Rats; D014946:Wound Infection / Q000382:microbiology / Q000517:prevention & control*
D004337:Drug Carriers; D004343:Drug Implants; D005839:Gentamicins; D011108:Polymers