Acute renal failure from inhalation of mycotoxins.
Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending 8 h in a granary which had been closed for several months, a farmer and his wife suffered temporary respiratory distress; 24 h later, the woman developed nonoliguric ARF and biopsy revealed tubulonecrosis which healed in 24 days. Toxic substances were not found, but a strain of A. ochraceus producing ochratoxin was isolated from the wheat.
Di Paolo
N
N
Nephrology and Dialysis Department, Regional Hospital of Siena, Italy.
Guarnieri
A
A
Loi
F
F
Sacchi
G
G
Mangiarotti
A M
AM
Di Paolo
M
M
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000280:Administration, Inhalation; D000383:Agriculture; D000818:Animals; D001235:Aspergillus ochraceus / Q000302:isolation & purification; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology; D009793:Ochratoxins / Q000009:adverse effects* / Q000633:toxicity; D011817:Rabbits; D014908:Triticum / Q000382:microbiology
D009793:Ochratoxins