title: [The effect of parenteral administration of 25-hydroxycholecalciferol and 1 alpha-hydroxycholecalciferol on the mineral concentrations in the blood of cows in late pregnancy].
abstract: The effect of 1 - 3 intramuscular injections of the vitamin D3 metabolite 25-OHD3, synthetic 1 alpha-OHD3, and a combination of both on the plasma concentrations of calcium (Ca), inorganic phosphate (P(i)) and magnesium (Mg) was tested in 67 older dry dairy cows. Administering 4,0 mg 25-OHD3 reduced Ca and P(i) for some time while Mg blood levels remained constant. Injecting 210 micrograms 1 alpha-OHD3 plus 2.0 mg 25-OHD3 only brought a marked increase in P(i) concentrations, whereas 420 micrograms 1 alpha-OHD3 plus 4.0 mg 25-OHD3, and 350 micrograms 1 alpha-OHD3 alone significantly raised Ca and P(i) levels beginning on the 2nd day after injection and lasting for at least 6 days. These higher levels can be maintained by repeated injections. Another effect of injecting 1 alpha-OHD3 was to depress Mg blood levels, and a negative effect on the Ca and vitamin D3 metabolism is suggested which may cause hypocalcaemia when the effect of 1 alpha-OHD3 subsides. Metastatic calcifications of soft tissues were observed in some 1 alpha-OHD3-treated cows.
authors.affiliation: Medizinische Tierklinik der Veterinärmedizinischen Fakultät, Universität, Leipzig.
authors.forename: H
authors.initials: H
authors.lastname: Zepperitz
authors.forename: H
authors.initials: H
authors.lastname: Schwabe
mesh_terms: D000818:Animals; D002112:Calcifediol / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle / Q000097:blood*; D005260:Female; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular / Q000662:veterinary; D008903:Minerals / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood* / Q000187:drug effects
chemical_list: D006887:Hydroxycholecalciferols; D008903:Minerals; D002112:Calcifediol; C008088:alfacalcidol
vernacular_title: Zur Wirkung von parenteral appliziertem 25-Hydroxycholecalciferol und 1 alpha-Hydroxy-cholecalciferol auf die Mineralstoffkonzentrationen im Blutplasma von hochträchtigen Kühen.