[D-dimer and plasminogen activator of the urokinase type: personal experiences with breast cancer].
Plasma values of d-dimer, a stable end product of plasmin-induced fibrinolysis, were ascertained in 128 female patients with mammary carcinoma. These patients demonstrated significantly increased d-dimers in comparison with the control group with benign mammary disease (p < 0.01). The sensitivity and specificity of d-dimer were slightly higher than those of the established tumour marker CA 15-3 and CEA. There was no correlation between d-dimers in the plasma and increased expression of urokinase plasminogen activator (UPA) in the tissue. Increased d-dimers in the plasma of female patients with mammary carcinoma reflect multi-factoral interactions between carcinoma growth and the haemostatic-fibrinolytic system, and may be used as tumour markers.
Neises
M
M
Frauenklinik, Fakultät für Klinische Medizin, Universität Heidelberg, Klinikum Mannheim.
Schäfer
T
T
Strittmatter
H J
HJ
Wischnik
A
A
Dettmar
P
P
Melchert
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000097:blood; D003131:Combined Modality Therapy; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D015409:Mastectomy, Radical; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000201:enzymology; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000201:enzymology / Q000601:surgery; D012307:Risk Factors; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood*
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D014568:Urokinase-Type Plasminogen Activator
D-Dimer und Plasminogen Aktivator vom Urokinasetyp: Eigene Erfahrungen bei Mammakarzinomen.