Antifungal macrocyclic polylactones from Penicillium verruculosum.
Three macrocyclic polylactones have been isolated from Penicillium verruculosum. Two were found to be novel and the third to be identical with NG-012(1). Their structures were elucidated by spectroscopic and chemical methods. A full assignment of 1H- and 13C-resonances in acetone-d6 are given for all three compounds. The compounds show antifungal activity.
Breinholt
J
J
Novo Nordisk A/S, Plant Protection Division, Bagsvaerd, Denmark.
Jensen
G W
GW
Nielsen
R I
RI
Olsen
C E
CE
Frisvad
J C
JC
D000818:Animals; D000935:Antifungal Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010407:Penicillium / Q000145:classification / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D007783:Lactones; D010636:Phenols; C078926:NG 011; C082788:BK223 C