title: Amyloid precursor protein is found in lysosomes.
abstract: The major component of Alzheimer's disease amyloid is a small polypeptide referred as the amyloid beta protein, which is derived from a larger precursor, amyloid precursor protein (APP). Cell fractionation and immunological studies on the APP molecule indicate that APP is localized either in the neuron and astrocyte and that the molecule is recovered from lysosomal fraction.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tagawa
authors.forename: M
authors.initials: M
authors.lastname: Yazaki
authors.forename: T
authors.initials: T
authors.lastname: Kinouchi
authors.forename: K
authors.initials: K
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Sorimachi
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Ishiura
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002460:Cell Line; D006801:Humans; D007120:Immunochemistry; D008247:Lysosomes / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D014162:Transfection
chemical_list: D016564:Amyloid beta-Protein Precursor