title: Normal levels of soluble CD4 in sera from patients with juvenile chronic arthritis.
abstract: Sera from a group of patients with juvenile chronic arthritis (JCA) were tested for soluble CD4 (sCD4). In most cases normal levels of the molecule were detected independent of disease activity. Similar results were obtained when sera from a population of adult rheumatoid arthritis (RA) patients were analyzed. Immunophenotypic studies of circulating mononuclear cells from seven JCA patients with active disease showed that T cells did not express activation markers. Finally, preliminary experiments showed that sCD4 levels were high in the synovial fluids from 3 RA patients as compared with paired serum determinations.
authors.affiliation: Laboratory of Immunopathology, Scientific Institute G. Gaslini, Genova, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Prigione
authors.forename: A
authors.initials: A
authors.lastname: Buoncompagni
authors.forename: M
authors.initials: M
authors.lastname: Cutolo
authors.forename: P
authors.initials: P
authors.lastname: Facchetti
authors.forename: G
authors.initials: G
authors.lastname: Morreale
authors.forename: V
authors.initials: V
authors.lastname: Pistoia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001171:Arthritis, Juvenile / Q000276:immunology*; D015704:CD4 Antigens / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values; D012217:Rheumatoid Factor / Q000032:analysis; D012995:Solubility; D013582:Synovial Fluid / Q000276:immunology
chemical_list: D015704:CD4 Antigens; D007075:Immunoglobulin M; D012217:Rheumatoid Factor