title: Response of ovary in young women experiencing laparoscopy under general anaesthesia.
abstract: This study investigated whether changes in circulating levels of immunoreactive oestradiol-17 beta (E2), progesterone (P) and testosterone (T) occur in women at follicular (n = 18, age 25 to 39 years) and luteal (n = 17, 25 to 39 years) phases of the normal menstrual cycles, experiencing laparoscopy after intravenous sedation with general anaesthesia. The pre- and intra-operative follicular phase plasma steroid hormone concentrations were 153.5 +/- 84.3 vs 297.4 +/- 220.8 pg/ml for E2, 2.0 +/- 3.2 vs 3.3 +/- 3.8 ng/ml for P and 746.6 +/- 415.9 vs 1325.8 +/- 535.1 pg/ml for T, respectively. The corresponding luteal phase steroid levels were 259.7 +/- 120.2 vs 382.7 +/- 188.7 pg/ml, 7.0 +/- 4.8 vs 9.9 +/- 6.1 ng/ml and 819.4 +/- 355.7 vs 1703.5 +/- 1058.1 pg/ml. Using the Wilcoxon rank sum test, intra-operative hormone levels with the exception of P in the luteal phase were found to be significantly elevated (p < 0.05). The results suggest that laparoscopy under general anaesthesia evokes increased secretion of ovarian hormones, possibly via the activation of hypothalamo-pituitary-ovarian axis.
authors.affiliation: University Department of Obstetrics & Gynaecology, National University Hospital, Singapore.
authors.forename: W P
authors.initials: WP
authors.lastname: Chow
authors.forename: A
authors.initials: A
authors.lastname: Loganath
authors.forename: K L
authors.initials: KL
authors.lastname: Peh
authors.forename: P C
authors.initials: PC
authors.lastname: Chew
authors.forename: R
authors.initials: R
authors.lastname: Gunasegaram
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005498:Follicular Phase; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D008183:Luteal Phase; D010053:Ovary / Q000378:metabolism*; D011374:Progesterone / Q000097:blood*; D013312:Stress, Physiological / Q000378:metabolism; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D011374:Progesterone; D004958:Estradiol