title: Benign trichogenic tumours: a report of two cases supporting a simplified nomenclature.
abstract: We report two cases of a rare benign tumour of hair germ. Clinically, both were solitary, well-circumscribed, subcutaneous nodules located in the extremities. Histologically, the tumours were characterized by nests and thin cords of basaloid epithelial cells intimately associated with a cellular stroma. The basaloid cells exhibited peripheral palisading, keratinization in the form of keratotic cysts and squamoid transformation, and pilar differentiation. An unusual, but distinctive, cribriform pattern of growth was observed. There was no communication with the overlying epidermis. Abundant primitive hair germinal buds and rare more advanced abortive hair follicles were identified. These histological appearances encompass features of both trichoblastic fibroma and trichogenic trichoblastoma, thus distinguishing these neoplasms from other skin tumours and reinforcing the hypothesis that these tumours are closely related from a histogenetic point of view. The presence of overlapping histological features can be problematic for practising histopathologists who rarely encounter these conditions. With this in mind, the term benign trichogenic tumour may be more appropriate to encompass these two tumours and related neoplasms that appear to lie within the spectrum of hair follicle development.
authors.affiliation: Dermatopathology Division, Massachusetts General Hospital, Boston.
authors.forename: T Y
authors.initials: TY
authors.lastname: Wong
authors.forename: J A
authors.initials: JA
authors.lastname: Reed
authors.forename: S
authors.initials: S
authors.lastname: Suster
authors.forename: S D
authors.initials: SD
authors.lastname: Flynn
authors.forename: M C
authors.initials: MC
authors.lastname: Mihm
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005260:Female; D005350:Fibroma / Q000473:pathology*; D006201:Hair Diseases / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009626:Terminology as Topic