Activities of two 9-deazaguanine analogue inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955, in vitro and in vivo.
Gilbertsen
R B
RB
Department of Immunopathology, Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Ann Arbor, Michigan 48105.
Dong
M K
MK
Josyula
U
U
Sircar
J C
JC
Wilburn
D J
DJ
Conroy
M C
MC
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003848:Deoxyguanine Nucleotides / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D013876:Thiophenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D003848:Deoxyguanine Nucleotides; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D013876:Thiophenes; C070377:CI 972; C076778:9-deaza-9-(3-thienylmethyl)guanine; D006147:Guanine; C029603:deoxyguanosine triphosphate; D011683:Purine-Nucleoside Phosphorylase