title: [Treatment of hyperthyroidism in children with antithyroid drugs].
abstract: Sixteen cases of pediatric hyperthyroidism treated by antithyroid drugs are reported. First-line treatment with carbimazole in a mean dose of 19 mg/m2 initially and 7 mg/m2 after one year ensured control of the disease within 6 weeks. Mean follow-up was 4 years. Only two children were able to discontinue the drug, after 9.1 years and 4.6 years. Two other patients had thyroidectomy, after 6.7 years and 3.4 years. The main disadvantages of antithyroid drugs are the need for prolonged treatment and the risk of recurrence. An attempt at treatment discontinuation is warranted in patients with good disease control of 2 to 3 years duration, goiter size reduction, improved exophthalmos, and decreased anti-TSH receptor antibodies.
authors.affiliation: Unité d'Endocrinologie Pédiatrique, Hôpital Necker, Enfants Malades, Paris.
authors.forename: H
authors.initials: H
authors.lastname: Thibault
authors.forename: D
authors.initials: D
authors.lastname: Clausse-Moysoulier
authors.forename: R
authors.initials: R
authors.lastname: Brauner
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D015992:Body Mass Index; D002231:Carbimazole / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D007223:Infant; D008297:Male; D012008:Recurrence; D013889:Thiouracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013954:Thyroglobulin / Q000037:antagonists & inhibitors; D013960:Thyroid Function Tests; D013965:Thyroidectomy
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D013889:Thiouracil; D002231:Carbimazole; D013954:Thyroglobulin; C019269:benzylthiouracil
vernacular_title: Traitement de l'hyperthyroïdie de l'enfant par les antithyroïdiens.