Origins of DNA replication that function in eukaryotic cells.
This past year has seen a significant increase in our understanding of eukaryotic origins of replication, of the proteins that identify these origins, of DNA sequences that promote their unwinding, and of transcription factors that stimulate origin activity. DNA replication begins at specific sites in both simple and complex genomes, but origins in complex genomes may include nuclear structure as well as DNA sequence.
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Roche Institute of Molecular Biology, Nutley, New Jersey 07110-1199.
D000818:Animals; D004261:DNA Replication; D006801:Humans