title: Chronic methanesulfonyl fluoride enhances one-trial per day reward learning in aged rats.
abstract: Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly greater speed and accuracy on a 1 trial/day discriminative reward learning task. The chronic MSF treatment resulted in a 56% decrease in brain AChE activity but no discernable locomotor side effects and no liver damage as indicated by aspartate transferase activity.
authors.affiliation: University of Houston-Clear Lake, TX 77058.
authors.forename: D H
authors.initials: DH
authors.lastname: Malin
authors.forename: R E
authors.initials: RE
authors.lastname: Plotner
authors.forename: S J
authors.initials: SJ
authors.lastname: Radulescu
authors.forename: R N
authors.initials: RN
authors.lastname: Ferebee
authors.forename: J R
authors.initials: JR
authors.lastname: Lake
authors.forename: P G
authors.initials: PG
authors.lastname: Negrete
authors.forename: P J
authors.initials: PJ
authors.lastname: Schaefer
authors.forename: M K
authors.initials: MK
authors.lastname: Crothers
authors.forename: D E
authors.initials: DE
authors.lastname: Moss
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000523:psychology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D004193:Discrimination Learning / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012201:Reward; D013450:Sulfones / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D002800:Cholinesterase Inhibitors; D013450:Sulfones; C005109:methanesulfonyl fluoride; D001219:Aspartate Aminotransferases; D000110:Acetylcholinesterase