title: A new technique using cultured epithelial sheets for the management of epistaxis associated with hereditary haemorrhagic telangiectasia.
abstract: A new technique for the treatment of severe epistaxis associated with hereditary haemorrhagic telangiectasia is described. The nasal septum and inferior turbinates, surgically denuded of respiratory epithelium, were grafted using autografts of cultured epithelial sheets derived from buccal epithelium. All patients upon whom this technique has been used have shown considerable lessening in the frequency and severity of their epistaxes although two patients received grafts on two occasions, in each case approximately three months apart. It is postulated that a nasal lining of stratified squamous epithelium is likely to be more resistant to trauma than the normal respiratory type, and this is supported by the observation that bleeds very seldom occur from the oral cavity in this syndrome.
authors.affiliation: Department of Otolaryngology, Kent and Sussex Hospital, Tunbridge Wells.
authors.forename: C M
authors.initials: CM
authors.lastname: Milton
authors.forename: J C
authors.initials: JC
authors.lastname: Shotton
authors.forename: D J
authors.initials: DJ
authors.lastname: Premachandran
authors.forename: B M
authors.initials: BM
authors.lastname: Woodward
authors.forename: J W
authors.initials: JW
authors.lastname: Fabre
authors.forename: R J
authors.initials: RJ
authors.lastname: Sergeant
mesh_terms: D002478:Cells, Cultured; D002610:Cheek; D004844:Epistaxis / Q000209:etiology / Q000601:surgery*; D004848:Epithelium / Q000637:transplantation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000601:surgery*; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications*; D014182:Transplantation, Autologous; D014420:Turbinates / Q000601:surgery*