Reproducibility of antipyrine half-lives in elderly subjects.
Antipyrine half-life determined on three to five separate occasions over a period ranging from 3 weeks to 1 year was highly reproducible in each of 20 elderly subjects (12 women and 8 men; mean age, 83 years). The mean within-subject coefficient of variation for antipyrine half-life was 9.6%, whereas the between-subject coefficient of variation was 33.3%. These findings indicate high reproducibility of individual rates of drug metabolism in medically stable elderly subjects.
Vesell
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ES
Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033.
DeAngelo
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TM
Katz
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D000368:Aged; D000369:Aged, 80 and over; D000983:Antipyrine / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D015203:Reproducibility of Results
D000983:Antipyrine