title: Acarosan and the Acarex test in the control of house dust mite allergens in the home.
abstract: House dust mites are believed to be major triggers for allergic disease in atopic individuals. As part of a programme controlling dietary and aero-allergen exposure in high-risk infants, an acaricidal foam and powder (Acarosan) was applied to bedroom and main living room carpets, as well as upholstered furniture, on four occasions in the first year of life. Dust was assayed for mite antigen (Der p1) and these results compared with the semi-quantitative assay of guanine content (Acarex Test). After nine months mean Der p1 levels had decreased by 70% in the treatment group. Proportionally, the greatest fall occurred in those items that had the highest initial mite antigen content. The Acarex score does show a correlation with Der p1 levels, but cannot replace antigen assay when accurate data is required. A chemical acaricide may help reduce house dust mite antigen levels, but is not by itself sufficient to reduce levels below that considered critical for sensitisation.
authors.affiliation: Clinical Allergy Research Unit, St Mary's Hospital, Newport, Isle of Wight.
authors.forename: S
authors.initials: S
authors.lastname: Ridout
authors.forename: R
authors.initials: R
authors.lastname: Twiselton
authors.forename: S
authors.initials: S
authors.lastname: Matthews
authors.forename: M
authors.initials: M
authors.lastname: Stevens
authors.forename: L
authors.initials: L
authors.lastname: Matthews
authors.forename: S H
authors.initials: SH
authors.lastname: Arshad
authors.forename: D W
authors.initials: DW
authors.lastname: Hide
mesh_terms: D000485:Allergens; D000818:Animals; D001565:Benzoates; D004391:Dust; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007223:Infant; D007306:Insecticides; D008925:Mites; D013983:Tick Control / Q000379:methods
chemical_list: D000485:Allergens; D001565:Benzoates; D004391:Dust; D007306:Insecticides; C006723:benzyl benzoate