title: Cardiac glycoside-induced elevation of intracellular Na+ ion concentration in human erythrocytes studied by 23Na NMR spectroscopy: relationship between inotropy speed and elevation rate of intracellular Na+ ion concentration.
abstract: Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin, and its four derivatives was measured using 23Na NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic effect and the time to maximum of Na+ concentrations in human erythrocyte, determined by 23Na NMR.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanase
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: A
authors.initials: A
authors.lastname: Nagatsu
authors.forename: J
authors.initials: J
authors.lastname: Sakakibara
mesh_terms: D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010210:Papillary Muscles / Q000187:drug effects; D011442:Proscillaridin / Q000031:analogs & derivatives / Q000494:pharmacology; D012964:Sodium / Q000097:blood*; D012975:Sodium Isotopes; D013816:Thermodynamics
chemical_list: D002301:Cardiac Glycosides; D012975:Sodium Isotopes; D012964:Sodium; D011442:Proscillaridin