Liquid chromatographic study of the stability of 5-halogeno-2'-deoxyuridines.
The stability of a series of 5-halogeno-2'-deoxyuridines was investigated using liquid chromatography as the analytical technique. Characteristics and profiles of the acidic, neutral and alkaline degradation are described, together with Arrhenius relationships and activation parameters for weakly acidic media.
Van Schepdael
A
A
Katholieke Universiteit Leuven, Instituut voor Farmaceutische Wetenschappen, Belgium.
Ossembe
N
N
Herdewijn
P
P
Roets
E
E
Hoogmartens
J
J
D001973:Bromodeoxyuridine / Q000032:analysis; D002021:Buffers; D002853:Chromatography, Liquid; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000032:analysis*; D004355:Drug Stability; D005467:Floxuridine / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007065:Idoxuridine / Q000032:analysis; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet
D002021:Buffers; D005467:Floxuridine; C012244:5-chloro-2'-deoxyuridine; D001973:Bromodeoxyuridine; D007065:Idoxuridine; D003857:Deoxyuridine