title: Intrathecal injection of high-dose meglumine amidotrizoate with complete recovery.
abstract: Rarely we are faced with accidental spinal injection of potentially toxic substances. We present 2 cases in which amidetrizoate, water-soluble ionic contrast medium, was accidentally injected intrathecally. Our treatment consisted of vigorous hydration and barbiturate coma. This report suggests that for water-soluble ionic contrast media increasing cerebrospinal fluid circulation by vigorous hydration may be as effective as spinal lavage in diminishing toxicity.
authors.affiliation: Department of Anesthesiology, Mie University Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Maruyama
authors.forename: Y
authors.initials: Y
authors.lastname: Setoguchi
authors.forename: J
authors.initials: J
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Chikusa
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ogihara
authors.forename: M
authors.initials: M
authors.lastname: Muneyuki
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects*; D003128:Coma / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000628:therapy; D003422:Critical Care / Q000379:methods; D003974:Diatrizoate Meglumine / Q000493:pharmacokinetics / Q000506:poisoning*; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D012640:Seizures / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D003974:Diatrizoate Meglumine