title: Repeated alcohol intake changes circadian rhythm of ambulatory blood pressure.
abstract: The blood pressure of 7 clinically healthy volunteering social drinkers was studied while they consumed, with a crossover design for 5 days, either 40 g of alcohol by day or fruit juice, with the two spans on alcohol and juice being separated by a one-week washout. Whereas the rhythm-adjusted mean was not changed, a clear statistically significant increase in the circadian double amplitude was found. The study provides a model for a rapidly achieved circadian amplitude hypertension which may precede an elevation of the overall blood pressure mean in the natural course of the disease.
authors.affiliation: Chronobiology Laboratories, University of Minnesota.
authors.forename: Y
authors.initials: Y
authors.lastname: Kumagai
authors.forename: T
authors.initials: T
authors.lastname: Shiga
authors.forename: K
authors.initials: K
authors.lastname: Sunaga
authors.forename: C
authors.initials: C
authors.lastname: Fukushima
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: A
authors.initials: A
authors.lastname: Ebihara
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D003971:Diastole / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008991:Monitoring, Physiologic; D013599:Systole / Q000187:drug effects / Q000502:physiology
chemical_list: D000431:Ethanol