Cardiac glycoside-induced elevation of intracellular Na+ ion concentration in human erythrocytes studied by 23Na NMR spectroscopy: relationship between inotropy speed and elevation rate of intracellular Na+ ion concentration.
Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin, and its four derivatives was measured using 23Na NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic effect and the time to maximum of Na+ concentrations in human erythrocyte, determined by 23Na NMR.
Tanase
T
T
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Murakami
N
N
Nagatsu
A
A
Sakakibara
J
J
D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010210:Papillary Muscles / Q000187:drug effects; D011442:Proscillaridin / Q000031:analogs & derivatives / Q000494:pharmacology; D012964:Sodium / Q000097:blood*; D012975:Sodium Isotopes; D013816:Thermodynamics
D002301:Cardiac Glycosides; D012975:Sodium Isotopes; D012964:Sodium; D011442:Proscillaridin