Role of N-6 and N-3 fatty acids in the dietary treatment of metabolic disorders.
The impetus to examine the effects on n-3 PUFA was generated from epidemiologic studies of a traditional population largely dependent on the marine environment. These studies and clinical interventions support a recommendation to increase the consumption of n-3 fatty acids, particularly in communities that currently have a low n-3 fatty acid intake. If we are to be guided by the diet of other traditional hunter-gatherer populations, dependent on both terrestrial and marine sources of food, it is clear that we may need to reappraise the importance of long chain PUFA of the n-6 series such as arachidonic acid. Recent studies on such populations indicate that elevated arachidonic acid levels, when associated with elevated n-3 PUFA, are likely not to be harmful to health.
Collier
G R
GR
Department of Human Nutrition, Deakin University, Geelong, Australia.
Sinclair
A J
AJ
D016718:Arachidonic Acid / Q000008:administration & dosage / Q000494:pharmacology; D001777:Blood Coagulation; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy; D004035:Diet Therapy; D004041:Dietary Fats / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000494:pharmacology; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D008055:Lipids / Q000097:blood
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008055:Lipids; D016718:Arachidonic Acid