title: Radioisotope assessment of heart damage in hypertransfused thalassaemic patients.
abstract: Twenty-five thalassaemic patients treated with repeated blood transfusion (BT) and intensive iron removal therapy were studied by echocardiography and rest/stress equilibrium gated radionuclide angiocardiography (EGNA). Stress left ventricular ejection fraction (LVEF) showed an important negative correlation with number of BTs (r = -0.75). Abnormal values of stress LVEF were measured after 200 BTs: these data demonstrate the effectiveness of stress LVEF in the follow-up of patients who have undergone repeated BTs and the clinical importance of intensive chelation therapy. Peak filling rate did not show diagnostic value in the early detection of iron cardiotoxicity. However, its inverse correlation with BT (r = -60) indicates that iron overload depresses the diastolic parameters.
authors.affiliation: Department of Experimental Medicine, University La Sapienza, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Scopinaro
authors.forename: M
authors.initials: M
authors.lastname: Banci
authors.forename: A
authors.initials: A
authors.lastname: Vania
authors.forename: R
authors.initials: R
authors.lastname: Tavolaro
authors.forename: O
authors.initials: O
authors.lastname: Schillaci
authors.forename: A
authors.initials: A
authors.lastname: Tisei
authors.forename: B
authors.initials: B
authors.lastname: Werner
authors.forename: G
authors.initials: G
authors.lastname: Digilio
authors.forename: F
authors.initials: F
authors.lastname: Ventriglia
authors.forename: V
authors.initials: V
authors.lastname: Colloridi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004452:Echocardiography; D005260:Female; D015637:Gated Blood-Pool Imaging; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007501:Iron / Q000009:adverse effects*; D008297:Male; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000628:therapy*
chemical_list: D007501:Iron