[Type IV collagenase activities in human colorectal cancers and its role in cancer invasion and metastasis].
In 36 patients with colorectal cancers, type IV collagenase activities were measured in cancer and non-cancer tissues for evaluating its role in the process of cancer invasion and metastasis. The colorectal cancer tissues revealed remarkably higher activities than the distant normal and tumor-neighboring mucosa (p < 0.001). The activities in the colorectal cancer tissues with high-grade histological venous invasion were higher than those with low-grade histological venous invasion (p < 0.005). But no differences of the activities were found between patients with and without hepatic metastasis. These results suggest that the type IV collagenase plays an important role in the cancer invasion to the blood vessels around the primary site in colorectal cancers.
Ambiru
S
S
First Department of Surgery, School of Medicine, Chiba University.
Miyazaki
M
M
Ito
H
H
Kaiho
T
T
Ando
K
K
Otawa
S
S
Ogata
A
A
Hayashi
S
S
Yasuda
N
N
Sarashina
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017364:Collagenases / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis
D017364:Collagenases