[Follow-up study of the development of autoantibodies in patients with chronic inflammatory bowel disease under anti-CD4 therapy].
7 of 22 patients with chronic inflammatory bowel diseases (Crohn's disease, ulcerative colitis) were treated with an anti-CD4-mAb. In the immunological monitoring the amounts of autoantibodies to pancreatic acini cells, to intestinal goblet cells, to granulocytes with perinuclear fluorescence pattern were examined and human anti-mouse-antibodies were measured. After anti-CD4 therapy the production of autoantibodies was widely unchanged. Therefore its use as parameter in the follow-up is restricted.
Buchwald
S
S
Institut für Immunologie, Rostock.
Emmrich
J
J
Seyfarth
M
M
Emmrich
F
F
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001323:Autoantibodies / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology*; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000628:therapy*; D003424:Crohn Disease / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D013997:Time Factors
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D015704:CD4 Antigens
Verlaufsstudie zum Auftreten von Autoantikörpern bei Patienten mit chronisch-entzündlichen Darmerkrankungen unter anti-CD4-Therapie.