title: Relationship of interleukin-4 to isotypic distribution of anti-double-stranded DNA antibodies in systemic lupus erythematosus.
abstract: IgG subclasses of anti-double-stranded DNA antibodies were determined in 182 patients with systemic lupus erythematosus. All isotypes were detected, but IgG1 and IgG3 were predominant (62 and 51% of the cases, respectively). An average of 64 +/- 27% was IgG1, 16 +/- 22% IgG2, 16 +/- 19% IgG3 and 4 +/- 10% IgG4. The rank order or frequency was IgG1, IgG3, IgG2 and IgG4 in patients with musculoskeletal involvement; IgG1, IgG2, IgG3 and IgG4 in those with renal complications; IgG3, IgG1, IgG2 and IgG4 in those with cutaneous involvement; and IgG1, IgG3, IgG2 and IgG4 in those with hematological manifestations. Interleukin-4 (IL-4) was detectable in 17 of 36 selected patients, as opposed to 1 of 40 normal controls. The percentage of the total autoantibody contributed by IgG1 was significantly higher (p < 0.03) in these patients than in the remainder with undetectable levels of IL-4.
authors.affiliation: Laboratoire d'Immunologie, CHU, Brest, France.
authors.forename: M
authors.initials: M
authors.lastname: Dueymes
authors.forename: J
authors.initials: J
authors.lastname: Barrier
authors.forename: J F
authors.initials: JF
authors.lastname: Besancenot
authors.forename: J
authors.initials: J
authors.lastname: Clèdes
authors.forename: C
authors.initials: C
authors.lastname: Conri
authors.forename: G
authors.initials: G
authors.lastname: Dien
authors.forename: A A
authors.initials: AA
authors.lastname: Drosos
authors.forename: J M
authors.initials: JM
authors.lastname: Dueymes
authors.forename: P
authors.initials: P
authors.lastname: Galanaud
authors.forename: B
authors.initials: B
authors.lastname: Grobois
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood*; D004247:DNA / Q000276:immunology*; D005260:Female; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000145:classification; D015847:Interleukin-4 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D000974:Antibodies, Antinuclear; D007132:Immunoglobulin Isotypes; D015847:Interleukin-4; D004247:DNA