Hydralazine predisposes to acute cutaneous vasculitis following urography with iopamidol.
We report a 60-year-old woman with renovascular hypertension who developed a severe cutaneous vasculitis 24 h after the injection of iopamidol during urography. A review of the literature suggests that her concomitant hydralazine therapy probably predisposed her to this reaction, as similar reactions have occurred in systemic lupus erythematosus, and hydralazine can induce a LE-like syndrome. We recommend that urography should be avoided in patients receiving hydralazine.
Reynolds
N J
NJ
Department of Dermatology, Bristol Royal Infirmary, U.K.
Wallington
T B
TB
Burton
J L
JL
D000075202:Contraindications; D004357:Drug Synergism; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects*; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging; D007479:Iopamidol / Q000009:adverse effects*; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced; D010309:Parotitis / Q000139:chemically induced; D014456:Ulcer / Q000139:chemically induced; D014567:Urography / Q000009:adverse effects*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology
D006830:Hydralazine; D007479:Iopamidol