Synthesis and pharmacological evaluation of a novel series of alpha-picolinium hydrazone analogues with anticipated antidiabetic activity.
A new series of substituted alpha-picolinium p-dimethylaminobenzalhydrazine derivatives and their o-hydroxy analogues has been prepared for evaluation of their efficacy as potential hypoglycemic agents. The synthesis was achieved by condensation of N-amino-alpha-picolinium perchlorate derivatives with the corresponding aromatic aldehydes. The structure of the synthesized products was inferred from elemental and spectral data. The hypoglycemic effect, antimicrobial activity and toxicity of the hitherto and possibly new chemotherapeutic agents were evaluated. Based on screening data, a possible structure-activity relationship has been discussed.
Girges
M M
MM
Chemistry Department, Mansoura University, Egypt.
Hanna
M A
MA
Gawinecki
R
R
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010847:Picolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010847:Picolines