title: Role of sputum cytology in the diagnosis of mediastinal germ cell tumor.
abstract: A rare case of germ cell tumor of the mediastinum infiltrating the lung and metastasizing to the supraclavicular lymph node in a 25-year-old male is presented. The patient presented with a history of superior vena cava syndrome and chest roentgenograms revealed an abnormal mediastinum. Primary positive diagnosis was made cytologically on sputum specimens. The peculiar cell type found in the Papanicolaou stained sputum smears were correlated with fine needle aspiration cytology of lung and lymph node, and confirmed the histologic pattern of the tumor metastasizing to the lymph node. To our knowledge, the present case is the first report of a primary mediastinal seminoma (germinoma) infiltrating the lung and diagnosed by sputum cytology. These results suggest the usefulness of sputum examination as an adjunctive diagnostic procedure in the detection of patients with possible lung infiltrated germinal neoplasms.
authors.affiliation: Division of Cytopathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: K R
authors.initials: KR
authors.lastname: Pillai
authors.forename: S
authors.initials: S
authors.lastname: Kannan
authors.forename: V P
authors.initials: VP
authors.lastname: Gangadharan
authors.forename: E K
authors.initials: EK
authors.lastname: Abraham
authors.forename: B
authors.initials: B
authors.lastname: Chandralekha
authors.forename: G R
authors.initials: GR
authors.lastname: Pillai
authors.forename: N S
authors.initials: NS
authors.lastname: Amma
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D004407:Dysgerminoma / Q000175:diagnosis* / Q000556:secondary; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D013183:Sputum / Q000166:cytology*