SDZ CO 611: a highly potent glycated analog of somatostatin with improved oral activity.
To obtain orally active octreotide (Sandostatin, SMS 201-995) analogs a new class of glycated somatostatin derivatives were synthesized by the Amadori reaction (Maillard reaction). The synthesis, chemical and biological characterization of a series of new compounds is described. These oligopeptides bind with high affinity to somatostatin receptors and retain full biological activity. Whereas generally polypeptide hormones are almost completely inactive after oral administration, we report here for the first time that these analogs show remarkably high activity by the oral route. Thus for example SDZ CO 611, the D(+)-maltose Amadori derivative of octreotide, has about 10 times higher oral effect bioavailability than octreotide while maintaining the selectivity, metabolic stability and long duration of action of the parent compound.
Albert
R
R
Sandoz Pharma Ltd., Preclinical Research Department, Basle, Switzerland.
Marbach
P
P
Bauer
W
W
Briner
U
U
Fricker
G
G
Bruns
C
C
Pless
J
J
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D006031:Glycosylation; D013006:Growth Hormone / Q000378:metabolism; D066298:In Vitro Techniques; D008253:Macaca mulatta; D015416:Maillard Reaction; D008297:Male; D015282:Octreotide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats
C082402:SDZ CO 611; D013006:Growth Hormone; D015282:Octreotide