title: Effects of rhynchophylline on motor activity of mice and serotonin and dopamine in rat brain.
abstract: Rhynchophylline (Rhy) reduced the spontaneous motor activity and enhanced the sedative and hypnotic effects of sodium pentobarbital in mice. The effects of Rhy on serotonin (5-HT) and dopamine (DA) concentrations in rat brain, and the release of 5-HT and DA from the regional brain slices were studied by a fluorescence detector. Rhy increased the 5-HT content in the hypothalamus and cortex, but reduced the DA concentrations in the cortex, amygdala, and spinal cord. Rhy promoted the release of endogenous DA from 4 brain regions. The release of 5-HT was increased in 2 brain regions and decreased in hypothalamus slice. However, Rhy inhibited the release of both 5-HT and DA evoked by high potassium.
authors.affiliation: Department of Pharmacology, Zunyi Medical College, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Shi
authors.forename: B
authors.initials: B
authors.lastname: Huang
authors.forename: Q
authors.initials: Q
authors.lastname: Wu
authors.forename: R X
authors.initials: RX
authors.lastname: Ren
authors.forename: X L
authors.initials: XL
authors.lastname: Xie
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D026121:Indole Alkaloids; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects*; D000078183:Oxindoles; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D026121:Indole Alkaloids; D000078183:Oxindoles; D012701:Serotonin; C052714:rhyncophylline; D004298:Dopamine