title: Destabilization of egg lecithin liposomes on the skin after topical application measured by perturbed gamma gamma angular correlation spectroscopy (PAC) with 111In.
abstract: Unilamellar and oligolamellar liposomes were topically applied to the skin of porcine ears. Perturbed angular correlation spectroscopy of 111In-DTPA, initially entrapped into the liposomes, was used to study the release kinetics of the hydrophilic probe. After drying of the liposomal suspensions, a decrease of the time-integrated perturbation factor <G22(infinity)> within 30 min indicated destabilization of the liposomes and total marker release in the upper epidermal layers.
authors.affiliation: Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schubert
authors.forename: M
authors.initials: M
authors.lastname: Joos
authors.forename: M
authors.initials: M
authors.lastname: Deicher
authors.forename: R
authors.initials: R
authors.lastname: Magerle
authors.forename: J
authors.initials: J
authors.lastname: Lasch
mesh_terms: D000818:Animals; D007205:Indium Radioisotopes; D008081:Liposomes / Q000032:analysis*; D004369:Pentetic Acid; D010713:Phosphatidylcholines / Q000737:chemistry; D012867:Skin / Q000737:chemistry*; D013057:Spectrum Analysis; D013552:Swine
chemical_list: D007205:Indium Radioisotopes; D008081:Liposomes; D010713:Phosphatidylcholines; D004369:Pentetic Acid