Platinum accumulation in the kidney and changes in creatinine clearance following chemotherapy with cisplatin in humans.
To evaluate the effects of repeated administration of cisplatin on kidney platinum (Pt) accumulation and renal function, Pt content in the kidney was determined in 31 autopsy cases and changes in creatinine clearance (CCr) were retrospectively assessed in 26 of 31 autopsy cases. There was no significant correlation between the cumulative dose of cisplatin and Pt content in the kidney. However, the kidney Pt level was correlated with the dose of cisplatin injected within a 7-month period prior to the patient's death. We suggest that the dose of cisplatin injected during a relatively short period before a patient's death affects Pt content in the kidney. Neither the total dose of cisplatin nor the Pt content in the kidney was significantly correlated with the decrease in CCr following chemotherapy with cisplatin.
Uozumi
J
J
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ueda
T
T
Yasumasu
T
T
Koikawa
Y
Y
Naito
S
S
Kumazawa
J
J
Kamura
T
T
Nakano
H
H
Sueishi
K
K
D002945:Cisplatin / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010984:Platinum / Q000378:metabolism*; D013997:Time Factors; D014565:Urogenital Neoplasms / Q000188:drug therapy
D010984:Platinum; D003404:Creatinine; D002945:Cisplatin