title: Amphotericin B and its delivery by liposomal and lipid formulations.
abstract: In recent years, new formulations of the original amphotericin B preparation (Fungizone) have been devised in order to overcome toxicity problems that frequently occur. These preparations represent an improved method of drug delivery, with an increased therapeutic index and a decrease in toxicity to mammalian cell membranes. The new formulations have different physico-chemical characteristics and differ in pharmacokinetic parameters. Their effects must be compared with conventional amphotericin B to ascertain potential roles in future antifungal therapy.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, University of London, U.K.
authors.forename: C
authors.initials: C
authors.lastname: Gates
authors.forename: R J
authors.initials: RJ
authors.lastname: Pinney
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers; D006801:Humans; D008055:Lipids; D008081:Liposomes
chemical_list: D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D000666:Amphotericin B