title: Mitotic activity in colorectal mucosa of healthy subjects in two Italian areas with different dietary habits.
abstract: The proliferative activity was evaluated in colorectal biopsies of 39 healthy subjects living in two distinct geographical areas, Trieste in northern and Florence in central Italy. Subjects living in Trieste had a significantly higher mitotic activity compared with subjects living in Florence (mitoses/cells counted x 100 were 0.17 +/- 0.04 in Trieste and 0.089 +/- 0.02 in Florence). The results of a dietary questionnaire also showed that subjects in Trieste consumed significantly fewer starches, fibers, nitrites, and proteins. However, no correlation was evident between the consumption of these nutrients and intestinal proliferation.
authors.affiliation: Department of Pharmacology, University of Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Caderni
authors.forename: F
authors.initials: F
authors.lastname: Bianchini
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: M T
authors.initials: MT
authors.lastname: Spagnesi
authors.forename: M
authors.initials: M
authors.lastname: Gabbrielli
authors.forename: U
authors.initials: U
authors.lastname: Ginanneschi
authors.forename: A
authors.initials: A
authors.lastname: Lagi
authors.forename: A
authors.initials: A
authors.lastname: Montigiani
authors.forename: F
authors.initials: F
authors.lastname: Cipriani
authors.forename: D
authors.initials: D
authors.lastname: Palli
mesh_terms: D000328:Adult; D000368:Aged; D002455:Cell Division; D003106:Colon / Q000166:cytology*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D012007:Rectum / Q000166:cytology*