title: Extracerebral toxoplasmosis in AIDS. Histological and immunohistological findings based on 80 autopsy cases.
abstract: Despite the great amount of literature concerning toxoplasmic encephalitis in AIDS patients, little is known about extracerebral toxoplasmosis. Therefore we conducted a study of 80 autopsy cases to estimate the frequency of extracerebral toxoplasmosis. A control group of 50 cases was completely negative for all markers applied. In 35 of the 80 AIDS-cases (43.7%), organisms could be detected. In 13 cases (16.2%) there was an extracerebral toxoplasmosis; 4 cases (5%) showed only extracerebral involvement and in 9 cases (11.2%), extracerebral toxoplasmosis occurred in combination with cerebral manifestations. In 22 cases (27.5%), only cerebral toxoplasmosis was found. The following organs were involved: cardiac muscle (15%), lungs (6.2%), liver (5%), pancreas (5%), gastrointestinal tract (6.2%), adrenal glands (5%), lymph nodes (5%) and testis (3.7%). In individual cases further organs, not mentioned above, were involved. Pseudocysts could be demonstrated within necroses and inflammatory foci by conventional staining, whereas trophozoites became apparent only immunohistologically.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Rudolf Virchow, Berlin, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Jautzke
authors.forename: M
authors.initials: M
authors.lastname: Sell
authors.forename: U
authors.initials: U
authors.lastname: Thalmann
authors.forename: K
authors.initials: K
authors.lastname: Janitschke
authors.forename: J
authors.initials: J
authors.lastname: Gottschalk
authors.forename: D
authors.initials: D
authors.lastname: Schürmann
authors.forename: B
authors.initials: B
authors.lastname: Ruf
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000311:Adrenal Glands / Q000382:microbiology; D000818:Animals; D002102:Cadaver; D004064:Digestive System / Q000382:microbiology; D006321:Heart / Q000382:microbiology; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008854:Microscopy, Electron; D010179:Pancreas / Q000382:microbiology; D012189:Retrospective Studies; D014122:Toxoplasma / Q000302:isolation & purification; D014123:Toxoplasmosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology*