Vaccination with hatched but non-activated, non-viable oncospheres of Taenia taeniaeformis in rats.
The usefulness of hatched but non-activated oncospheres as a candidate vaccine was evaluated using a Taenia taeniaeformis/rat system, since preparation of these oncospheres in vitro is known to be very simple. The findings were: (1) rats vaccinated with non-viable oncospheres became completely resistant to challenge infection; (2) intra-venous injection was the most effective to induce complete resistance; (3) a single oncosphere was sufficient to induce complete resistance in infected rats, whereas approximately 50 and 500 non-viable oncospheres were required to evoke strong and complete resistance, respectively, in vaccinated rats. The usefulness of non-viable oncospheres without adjuvant is discussed.
Ito
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Department of Parasitology, Gifu University School of Medicine, Japan.
Hashimoto
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D000818:Animals; D003551:Cysticercosis / Q000517:prevention & control*; D007275:Injections, Intravenous; D008297:Male; D011897:Random Allocation; D051381:Rats; D013047:Specific Pathogen-Free Organisms; D013621:Taenia / Q000276:immunology*; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage
D014612:Vaccines