Rearrangement of the N-myc oncogene in acute leukemias: a case report.
Rearrangements of the N-myc oncogene have not been described in the literature. The authors present a case of ANLL with the N-myc gene rearranged out of 16 ANLLs and 11 ALLs. While the proportion of the blast cells in the case reported was 85%, the rearranged gene gave a hybridization band which was less intense than that of the germline band, making it probable that this gene rearrangement is present in a leukemia subclone. The c-myc oncogene as well as Ig and TcR genes were in germline configurations. The presence of the rearranged N-myc in the reported case could imply an alternative mechanism of mutation of this oncogene in the pathogenesis of hematological malignancies.
Casares
S
S
Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Rodriguez
J M
JM
Martin
A
A
Parrado
A
A
D000368:Aged; D015703:Antigens, CD / Q000097:blood; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D015321:Gene Rearrangement; D016259:Genes, myc; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics* / Q000276:immunology; D009000:Monocytes / Q000502:physiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics; D015183:Restriction Mapping
D015703:Antigens, CD; D015342:DNA Probes; D004273:DNA, Neoplasm; D006684:HLA-DR Antigens