title: Diabetes increases excretion of urinary malonaldehyde conjugates in rats.
abstract: The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992) Lipids 27, 124-128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.
authors.affiliation: Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108.
authors.forename: D D
authors.initials: DD
authors.lastname: Gallaher
authors.forename: A S
authors.initials: AS
authors.lastname: Csallany
authors.forename: D W
authors.initials: DW
authors.lastname: Shoeman
authors.forename: J M
authors.initials: JM
authors.lastname: Olson
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000652:urine; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde