title: Single-dose versus 3-day prophylaxis with ciprofloxacin in transurethral surgery. A clinical trial.
abstract: In 235 patients who underwent transurethral surgery, perioperative oral ciprofloxacin prophylaxis was given as a single dose 500 mg versus a 3-day regimen. Out of 180 evaluable patients, 84 received a single dose and 96 received a 3-day course. In the single dose prophylaxis group there were 5 failures and in the 3-day prophylaxis group there were 6 failures. The difference is not significant. In 17 patients whose urine culture preoperatively yielded microorganisms the 3-day prophylaxis significantly eradicated the bacteriuria in 83% of the patients.
authors.affiliation: Urologic Department, University Hospital, Maastricht, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Bijl
authors.forename: R A
authors.initials: RA
authors.lastname: Janknegt
mesh_terms: D016470:Bacteremia / Q000382:microbiology / Q000517:prevention & control*; D001437:Bacteriuria / Q000382:microbiology / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D014551:Urinary Tract / Q000601:surgery*
chemical_list: D002939:Ciprofloxacin