Low doses of radiation induce systemic production of cytokines: possible contribution to leukemogenesis.
Experiments were conducted to explore the possible effect of low-dose irradiation on cytokine production in mice. SJL/J and C57BL/6J mice were exposed to 3 Gy and 4 Gy respectively. At various time intervals thereafter, lung-conditioned media, bone-marrow-conditioned media and sera were collected. Interleukin-6 and macrophage-colony-stimulating-factor activities were tested. Interleukin-6 in lung-conditioned media from both strains was found to be significantly induced by irradiation. Macrophage-colony-stimulating-factor activity was greatly enhanced in sera of irradiated SJL/J mice as well as in bone-marrow-conditioned media of both strains. The kinetics of the radiation-induced interleukin 6 and macrophage-colony-stimulating-factor activity differed in the 2 strains. SJL/J and C57BL/6J mice have been previously shown to be susceptible to low-dose-radiation-induced leukemia. The coleukemogenic effects of both cytokines in 3 different models of experimental leukemogenesis is demonstrated.
Tartakovsky
B
B
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Goldstein
O
O
Krautghamer
R
R
Haran-Ghera
N
N
D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D003907:Dexamethasone / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D015850:Interleukin-6 / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D007942:Leukemia, Experimental / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains
D016207:Cytokines; D015850:Interleukin-6; D003907:Dexamethasone; D016173:Macrophage Colony-Stimulating Factor