title: Origin of senescence: a review.
abstract: The aging process is controlled by dual mechanisms. One is the mechanism which programs ultimate cell death and therefore determines the life-span at birth. The other is the mechanism which causes aging stochastically by damaging certain substances with time in life. Now, these mechanisms have been investigated on genetical bases. Whatever the mechanisms involved in aging, increasing evidence suggests the important roles of oxygen free radicals in the process of aging.
authors.affiliation: Department of Molecular Biology, School of Medicine, Tokai University, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans
chemical_list: D005609:Free Radicals