Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Walker
K A
KA
Syntex Discovery Research, Palo Alto, California 94304.
Kertesz
D J
DJ
Rotstein
D M
DM
Swinney
D C
DC
Berry
P W
PW
So
O Y
OY
Webb
A S
AS
Watson
D M
DM
Mak
A Y
AY
Burton
P M
PM
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D051381:Rats; D013237:Stereoisomerism; D058886:Sterol 14-Demethylase; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis* / Q000494:pharmacology
D000814:Aniline Compounds; D000924:Anticholesteremic Agents; C548418:CYP51A1 protein, human; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D013440:Sulfides; C082410:azalanstat; D002784:Cholesterol; D010088:Oxidoreductases; D058886:Sterol 14-Demethylase