[Resistance to the action of insulin].
The author analyses the insulin and glucagon effect on glycaemia regulation. The structure of glucose transporters and insulin receptors is described in some detail. Finally the author attempts to explain the insulin resistance mechanism based on a post receptor alteration that would be advantageous in traditional nutrition, but is noxious in a western type society, due to excessive caloric intake.
Azevedo
M da S
Mda S
Instituto de Química Fisiológica, Faculdade de Medicina de Lisboa.
D001692:Biological Transport; D001786:Blood Glucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism
D001786:Blood Glucose; D011972:Receptor, Insulin; D005947:Glucose
Resistência à acção da insulina.