title: Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children.
abstract: Rates of acquisition and mean duration of nasal carriage of different serotypes of Streptococcus pneumoniae have been estimated by fitting a stochastic model to longitudinal carriage data in children from Papua New Guinea. Immunogenicity and two indices of relative invasiveness were determined for each serotype. Immunogenic serotypes were less frequently acquired and were carried for shorter periods, but no relationship between immunogenicity and invasiveness was apparent using either index of invasiveness. Frequent invasion was associated with a high acquisition rate and high frequency and prolonged duration of carriage. Carriage studies can provide a broad indication of which serotypes cause invasive disease but not the proportion of disease due to individual serotypes; some serotypes which cause invasive disease (e.g. serotype 46) are not found even in extensive carriage studies. The antibiotic resistance of carriage organisms, however, does approximate the resistance patterns of invasive organisms and thus may be used to monitor changing patterns of antimicrobial susceptibility in the community.
authors.affiliation: Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province.
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Lehmann
authors.forename: J
authors.initials: J
authors.lastname: Montgomery
authors.forename: M
authors.initials: M
authors.lastname: Gratten
authors.forename: I D
authors.initials: ID
authors.lastname: Riley
authors.forename: M P
authors.initials: MP
authors.lastname: Alpers
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D002353:Carrier State / Q000453:epidemiology; D002648:Child; D006801:Humans; D008137:Longitudinal Studies; D015233:Models, Statistical; D009297:Nasal Mucosa / Q000382:microbiology; D010219:Papua New Guinea / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D012703:Serotyping / Q000379:methods; D013269:Stochastic Processes; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D000907:Antibodies, Bacterial