Automatic determination of amylocaine and bromhexine by atomic absorption spectrometry.
An automatic method for the determination of amylocaine and bromhexine hydrochloride by atomic absorption spectrometry (AAS) is proposed. The drugs were determined indirectly by formation of reineckates, extraction into 1,2-dichloroethane and measurement of chromium in the organic phase. The chemical conditions and experimental variables influencing the performance of the flow system of the liquid-liquid extractor were established. The proposed method allows the determination of amylocaine and bromhexine at concentrations between 3 and 120 micrograms ml-1 with a relative standard deviation of 1 and 3%, respectively, even in the presence of other synthetic drugs.
Eisman
M
M
Department of Analytical Chemistry, Faculty of Sciences, University of Córdoba, Spain.
Gallego
M
M
Valcárcel
M
M
D001322:Autoanalysis; D001565:Benzoates / Q000032:analysis*; D001964:Bromhexine / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D013054:Spectrophotometry, Atomic; D013861:Thiocyanates
D001565:Benzoates; D007202:Indicators and Reagents; D013861:Thiocyanates; C001818:Reinecke Salt; D001964:Bromhexine; C015677:amylocaine