title: Occupational dermatitis from isothiazolinones in the nylon production.
abstract: Kathon is a biocide consisting of a mixture of two isothiazolinone derivatives (5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one) in an approximate ratio of 3:1, respectively, and with MgCl2 and Mg(NO3)2 present as stabilizers. The isothiazolinones are marketed under several brand names, and the concentration of the active ingredient varies according to their intended application. At a concentration of 3-15 ppm it shows activity against a wide spectrum of fungi, gram-positive and gram-negative bacteria. Contact allergy to it has been caused by cosmetics and also by products used in the pottery and various other industries. Recently we had the opportunity to observe 6 cases of occupational allergic contact dermatitis from an isothiazolinone mixture named Grotan TK 2 in a large textile industry producing nylon. An oil emulsion containing isothiazolinones is used in the spinning phase of the work cycle to prevent bacterial contamination that would damage yarn quality; furthermore, it helps to decrease the electrostatic charge that is produced by high speed at which the yarn moves and also to decrease the breakage possibility.
authors.affiliation: Department of Dermatology, Ospedali Riuniti di Bergamo, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Valsecchi
authors.forename: P
authors.initials: P
authors.lastname: Leghissa
authors.forename: S
authors.initials: S
authors.lastname: Piazzolla
authors.forename: T
authors.initials: T
authors.lastname: Cainelli
authors.forename: P
authors.initials: P
authors.lastname: Seghizzi
mesh_terms: D002675:Child, Preschool; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000175:diagnosis / Q000209:etiology*; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009757:Nylons; D010328:Patch Tests; D013783:Textile Industry; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D009757:Nylons; D013844:Thiazoles; C037057:Kathon 886