Changes in retinal nerve fiber layer thickness after reduction of intraocular pressure in chronic open-angle glaucoma.
OBJECTIVE
The authors evaluated the relative nerve fiber layer height changes in glaucomatous eyes after reduction of intraocular pressure (IOP) after trabeculectomy using image analysis techniques.


METHODS
Optic disc topography and relative nerve fiber layer height of 12 eyes of 12 patients with chronic open-angle glaucoma were measured using a Rodenstock optic nerve head analyzer and Caprioli's program for nerve fiber layer height determination before trabeculectomy and at 2 or more months after surgery.


RESULTS
Changes in relative nerve fiber layer height after surgery, as well as those in cup volume and rim area, showed statistically significant correlation with the degree of reduction of IOP (Spearman's correlation coefficient = 0.66; P < 0.05). Changes in the mean deviation of Humphrey visual field showed a slight correlation with IOP reduction (Spearman's correlation coefficient = 0.55; P < 0.1).


CONCLUSIONS
Nerve fiber layer height changes that may occur after trabeculectomy are pressure-dependent.
Sogano
S
S
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Tomita
G
G
Kitazawa
Y
Y
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005901:Glaucoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005902:Glaucoma, Open-Angle / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology; D012160:Retina / Q000473:pathology*; D014130:Trabeculectomy