1-Carboranyl-3-(2-methylaziridino)-2-propanol. Synthesis, selective uptake by B-16 melanoma, and selective cytotoxicity toward cancer cells.
1-Carboranyl-3-(2-methylaziridino)-2-propanol (MACB) was prepared from the reaction of 1-carboranyl-2,3-epoxypropane with metalated methylaziridines having copper [Cu(CN)Li2]1/2 or lead (PbBu3) as the metal. MACB exhibited relatively high growth inhibition toward some cancer cells, and selective uptake of MACB by B-16 melanoma was accomplished.
Yamamoto
Y
Y
Department of Chemistry, Faculty of Science, Tohoku University, Sendai, Japan.
Nakamura
H
H
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001388:Aziridines / Q000138:chemical synthesis*; D006801:Humans; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000378:metabolism; D020005:Propanols; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D001388:Aziridines; D020005:Propanols