The hibernating myocardium in ischaemia and congestive heart failure.
Hibernating myocardium refers to the presence of persistent myocardial and left ventricular dysfunction at rest due to reduced coronary blood flow that can be partially or completely restored to normal by myocardial revascularization. An increasing amount of data show it is most likely a downgrading of cardiac function so that blood flow and myocardial function are once again in a state of equilibrium. It has been demonstrated to occur in patients with unstable angina, chronic stable angina, acute myocardial infarction and in left ventricular dysfunction and/or congestive heart failure. Salvage of this viable myocardium by successful revascularization improves left ventricular dysfunction and probably also patient survival. Therefore, diagnosis of hibernating myocardium is important because it does not render left ventricular dysfunction a necessary contraindication to revascularization, nor does it leave the patient with chronic heart failure a candidate only for cardiac transplantation. Instead, these patients should have complete revascularization by coronary bypass surgery/percutaneous transluminal coronary angioplasty as soon as possible.
Rahimtoola
S H
SH
Griffith Center, University of Southern California School of Medicine, Los Angeles.
D000787:Angina Pectoris / Q000503:physiopathology; D000789:Angina, Unstable / Q000503:physiopathology; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000502:physiology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*