Suicide inhibition of monoamine oxidases A and B by (-)-deprenyl. A computer-aided solution for determining inhibition specificity.
An analytical solution to the differential equations describing the kinetics of the suicide inhibition of a two-enzyme system has been derived and the modelling of suicide inhibition of the monoamine oxidases A and B (MAO A and B, EC 1.4.3.4) by a quasi-selective agent, (-)-deprenyl, is presented as an example. A new parameter, the specificity index is defined and used in a model which describes the specific and non-specific binding of (-)-deprenyl to MAO B and MAO A, respectively. This type of analysis may be of therapeutic value by indicating optimal dosage of quasi-selective MAO B inhibitors for the treatment of Parkinson's disease.
Batke
J
J
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest.
Gaál
J
J
D000818:Animals; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D012642:Selegiline / Q000494:pharmacology*; D013379:Substrate Specificity
D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline