Are leukotrienes or PAF involved in hyperbaric oxygen toxicity?
Several very selective leukotriene inhibitors, and a PAF inhibitor, suitable for in vivo use, have been tested for their effects on hyperbaric oxygen toxicity. The leukotriene D4 inhibitor, L660771, and the 5-lipoxygenase pathway inhibitor L663536, failed to affect convulsions or lung damage induced by hyperbaric oxygen (pressure range 515-615 kPa) in either rats or mice. The specific PAF antagonist L659989 showed marginal protection against hyperoxic convulsions and did not alter pulmonary damage. The specific LTB4 antagonist SC-41930 was very effective in inhibiting hyperbaric oxygen-induced convulsions in both rats and mice. SC-41930 also very significantly protected rats against pulmonary oxygen toxicity, but had only marginally significant effects on pulmonary protection in mice.
Lin
Y
Y
School of Physiology and Pharmacology, University of New South Wales, Kensington, Australia.
Jamieson
D
D
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D005260:Female; D005663:Furans / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors; D015289:Leukotrienes / Q000502:physiology*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010100:Oxygen / Q000633:toxicity*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011312:Pressure; D011422:Propionates / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D013189:SRS-A / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D013047:Specific Pathogen-Free Organisms; D002722:Chlorobenzenes
D001578:Benzopyrans; D005663:Furans; D007211:Indoles; D007975:Leukotriene B4; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D010100:Oxygen; D010972:Platelet Activating Factor; D011422:Propionates; D011804:Quinolines; D013189:SRS-A; C060893:MK-886; D002722:Chlorobenzenes; C059950:SC 41930; C054893:L 659989; C059141:verlukast