Anti-inflammatory activity of two flavonoids from Tanacetum microphyllum.
The CH2Cl2 extract of Tanacetum microphyllum aerial parts exhibited anti-inflammatory activity and yielded two anti-inflammatory flavonoids: 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone (centaureidin) [1], and 5,3'-dihydroxy-4'-methoxy-7-carbomethoxyflavonol [2]. This is the first report of the chemical composition of Ta. microphyllum and of the isolation of centaureidin from the genus Tanacetum.
Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
M J
MJ
Abad
P
P
Bermejo
A
A
Villar
S
S
Valverde
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D044948:Flavonols; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013030:Spain; D013056:Spectrophotometry, Ultraviolet
C083162:5,3'-dihydroxy-4'-methoxy-7-carbomethoxyflavonol; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; C083161:centaureidin; D002351:Carrageenan