Inositol trisphosphate and calcium signalling.
Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.
AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK.
M J
MJ
Berridge
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D015220:Calcium Channels; D002453:Cell Cycle; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D005260:Female; D005306:Fertilization; D019204:GTP-Binding Proteins / Q000502:physiology; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism / Q000502:physiology*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008297:Male; D008954:Models, Biological; D009473:Neuronal Plasticity; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology; D011950:Receptors, Cholinergic / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear; D012433:Ryanodine / Q000494:pharmacology; D019837:Ryanodine Receptor Calcium Release Channel; D015290:Second Messenger Systems; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic; D018160:Receptors, Cytoplasmic and Nuclear; D019837:Ryanodine Receptor Calcium Release Channel; D012433:Ryanodine; D015544:Inositol 1,4,5-Trisphosphate; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; D002118:Calcium