Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor.
Salvino
J M
JM
Department of Medicinal Chemistry and Enzymology, Sterling Winthrop Pharmaceutical Research Division, Pennsylvania 19426-0900.
Seoane
P R
PR
Douty
B D
BD
Awad
M M
MM
Dolle
R E
RE
Houck
W T
WT
Faunce
D M
DM
Sawutz
D G
DG
D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive; D006168:Guinea Pigs; D006801:Humans; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009281:Naphthalenes / Q000138:chemical synthesis / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D009281:Naphthalenes; D009943:Organophosphorus Compounds; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter