A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys.
The effects of a human GM-CSF/IL-3 fusion protein (PIXY321) were examined in a primate model of rebound hematopoiesis following sublethal irradiation. The results demonstrated an enhanced rate of both neutrophil and platelet regeneration, as well as functional activation of circulating neutrophils.
Williams
D E
DE
Department of Experimental Hematology, Immunex Corporation, Seattle, Washington 98101.
Dunn
J T
JT
Park
L S
LS
Frieden
E A
EA
Seiler
F R
FR
Farese
A M
AM
Macvittie
T J
TJ
D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D004355:Drug Stability; D004797:Enzyme-Linked Immunosorbent Assay; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000493:pharmacokinetics / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000378:metabolism; D007377:Interleukin-3 / Q000493:pharmacokinetics / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D011993:Recombinant Fusion Proteins / Q000493:pharmacokinetics / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D007377:Interleukin-3; C078524:PIXY321 fusion protein, recombinant; D011993:Recombinant Fusion Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006861:Hydrogen Peroxide