Lagunamycin, a novel 5-lipoxygenase inhibitor. I. Taxonomy, fermentation, physico-chemical properties and biological characteristics.
Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08 microM) without lipid peroxidation.
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Y
Y
Nihei
M
M
Hasegawa
K
K
Suzuki
S
S
Yamamoto
M
M
Hanada
T
T
Furumai
Y
Y
Fukagawa
T
T
Oki
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D003979:Diazonium Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D016859:Lipoxygenase Inhibitors; D051379:Mice; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D003979:Diazonium Compounds; D016859:Lipoxygenase Inhibitors; D015363:Quinolones; C082420:lagunamycin