[Synthesis and antigenic activity of peptides from core- and NS3-proteins of hepatitis C virus].
We synthesized the 20-34 and 22-34 fragments of the core and 1269-1282 fragment of the NS3 protein of the hepatitis C virus. The peptides were prepared by the solid-phase synthesis using activated esters and symmetrical anhydrides of Boc-amino acids. Peptide 20-34 demonstrated positive reaction in ELISA with all individual sera from HCV chronic patients. Peptide 1269-1282 reacted with 33% patients sera.
Semiletov
Iu A
IuA
Firsova
T V
TV
Shibnev
V A
VA
Viazov
S O
SO
D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000276:immunology*; D016174:Hepacivirus / Q000737:chemistry*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000276:immunology; D014758:Viral Core Proteins / Q000737:chemistry*; D017361:Viral Nonstructural Proteins / Q000737:chemistry*
D000956:Antigens, Viral; D010446:Peptide Fragments; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins