Somatic ribosomal changes induced by long-term potentiation of the perforant path-hippocampal CA1 synapses.
The present study quantified ribosomes, as an ultrastructural marker of neuronal protein synthesis, following long-term potentiation (LTP) in the hippocampal CA1 region in vitro. Sixty min after LTP-inducing, high-frequency stimulation of the perforant path, the total number of ribosomes, the number of polysomes, and the number of membrane-bound ribosomes increased significantly. These increases are a postsynaptic morphological correlate consistent with enhanced protein synthesis following the induction of LTP in the perforant path-CA1 system.
Wenzel
J
J
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
Desmond
N L
NL
Levy
W B
WB
D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000502:physiology* / Q000648:ultrastructure; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D011132:Polyribosomes / Q000502:physiology / Q000648:ultrastructure; D011712:Pyramidal Tracts / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012270:Ribosomes / Q000502:physiology* / Q000648:ultrastructure*; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure