[Changes in 31P-MR spectroscopy in murine experimental tumor (SCC VII) after irradiation].
Changes in the phosphate metabolism of transplanted squamous cell carcinoma VII (SCC VII) tumor were studied after irradiation using in vivo 31P-magnetic resonance spectroscopy (MRS). The results were as follows. 1) Phosphocreatine (PCr), gamma-,alpha- and beta-ATP, inorganic phosphate (Pi), phosphomonoester (PME) and phosphodiester (PDE) were detected in 31P-MR spectroscopy of SCC VII solid tumor. 2) 31P-MRS parameters, including PCr, beta-ATP, PCr/Pi, beta-ATP, beta-ATP/Pi and pH, increased after irradiation, then decreased with tumor regrowth. 3) Pi, PME and PDE decreased transiently after irradiation, and thereafter increased gradually. 4) PCr/Pi showed the most remarkable increase (p < 0.05) of all parameters following irradiation. Therefore, it may be employed as a therapeutic index in radiation therapy. Because PCr/Pi decreased again after irradiation prior to regrowth of tumor, it may be used to predict tumor regrowth. From these results, it was suggested that 31P-MRS was useful for monitoring the effects of radiation therapy, and regrowth after irradiation.
Department of Radiology, Aichi Medical University.
H
H
Hori
Y
Y
Itoh
M
M
Aihara
Y
Y
Ayakawa
N
N
Miyata
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D010710:Phosphates / Q000032:analysis*
D014408:Biomarkers, Tumor; D010710:Phosphates