Adeno-associated virus: integration at a specific chromosomal locus.
Recent characterization of integration of the human parvovirus, adeno-associated virus, has uncovered the exciting occurrence of targeted integration. Thus far, such specific integration has been found to be unique among the eukaryotic viruses. The molecular details of the steps involved in virus integration are actively being pursued and should yield significant information for our understanding of the mechanisms of DNA transposition.
Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
R J
RJ
Samulski
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002522:Chlorocebus aethiops; D000229:Dependovirus / Q000235:genetics* / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D006378:Helper Viruses / Q000502:physiology; D006801:Humans; D007668:Kidney; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011533:Proviruses / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D012091:Repetitive Sequences, Nucleic Acid; D014775:Virus Activation; D016662:Virus Integration; D014779:Virus Replication