Chloride channels.
Cl- channels have various functions such as regulation of cell volume, transepithelial transport, and control of excitability in nerve and muscle. Several different structural classes of Cl- channels have been identified recently by molecular cloning. The importance of these different classes of Cl- channels can be seen from the inherited diseases resulting from mutations in some of the genes encoding them. Mutagenesis studies are beginning to shed light on their structure-function relationships.
Centre for Molecular Neurobiology (ZMNH), Hamburg University, Germany.
T J
TJ
Jentsch
D000818:Animals; D018118:Chloride Channels; D002712:Chlorides / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*
D018118:Chloride Channels; D002712:Chlorides; D008565:Membrane Proteins