Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania.
Membrane phospholipids were measured in platelets of seven medication-free patients in the manic phase of bipolar affective disorder and seven healthy comparison subjects. The relative percentage of platelet membrane phosphatidylinositol-4,5-bisphosphate was significantly higher in the manic patients than in the comparison subjects. These results are consistent with an enhanced neuronal second messenger response after 5-hydroxytryptamine receptor stimulation followed by neurotransmitter release.
Brown
A S
AS
Department of Psychiatry, University of Pittsburgh School of Medicine, Pa.
Mallinger
A G
AG
Renbaum
L C
LC
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood*; D001792:Blood Platelets / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000097:blood*
D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols