[The effect of alpha-melanocyte-stimulating hormone and its analog on the growth of human melanoma cell lines with different phenotypes].
Investigation of physiological effects of alpha-MSH and its analog (NLe4, D-Phe7)-alpha-MSH on human melanoma cells with different phenotypes has shown that these peptides have a growth-modulating activity. The effect of inhibition or activation of the growth of melanoma cells depended on their phenotypes. (NLe4, D-Phe7)-alpha-MSH activated 1.5-2.5-fold the growth of amelanotic BRO cells at concentrations of 10(-6)-10(-12) M, but inhibited the growth of melanin-producing MS cells under the same conditions not affecting the growth of human lung fibroblasts.
Morozova
L F
LF
D'iakov
V L
VL
Sukhanov
V A
VA
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000166:cytology / Q000187:drug effects; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D010641:Phenotype; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects; D000521:alpha-MSH / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*
D000521:alpha-MSH; C027756:MSH, 4-Nle-7-Phe-alpha-