Effects of menatetrenone on bone loss induced by ovariectomy in rats.
The effects of menatetrenone, a vitamin K2 homologue, on bone loss induced by ovariectomy in rats were studied in 3 experiments. Menatetrenone was given as a dietary supplement. In experiment 1, at 2 weeks postovariectomy, menatetrenone (10 mg/kg/day given for 2 weeks) inhibited the decrease in bone density of the femoral metaphysis induced by the ovariectomy. In experiment 2, menatetrenone (3 or 30 mg/kg/day given for 6 months) inhibited the decrease in bone strength of the femur and the decrease in calcium and hydroxyproline content of the femoral diaphysis at 6 months postovariectomy. In experiment 3, menatetrenone treatment, at 30 or 100 mg/kg/day for 6 months, protected against the decrease in bone strength and calcium and hydroxyproline content in the bone loss model induced by ovariectomy and calcium-deficient diet. These findings suggest that menatetrenone protects against the bone loss induced by ovariectomy.
Department of Drug Research II, Eisai Co., Ltd., Tokyo, Japan.
Y
Y
Akiyama
K
K
Hara
I
I
Ohkawa
T
T
Tajima
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002136:Calcium, Dietary / Q000008:administration & dosage; D005260:Female; D005269:Femur / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D010052:Ovariectomy; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D024482:Vitamin K 2 / Q000031:analogs & derivatives
D002136:Calcium, Dietary; D024482:Vitamin K 2; D014812:Vitamin K; C030814:menatetrenone