Spectrum of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders. A proposal for classification and guidelines for management and treatment.
Primary cutaneous CD30 (Ki-1)-positive, large cell lymphomas (LCLs) represent a recently recognized group of cutaneous T-cell lymphomas with a favorable prognosis. The characteristic features of this cutaneous lymphoma are reviewed, differences with primary noncutaneous CD30+ LCLs emphasized, and its relation with other CD30+ cutaneous lymphoproliferative disorders, in particular lymphomatoid papulosis, is discussed. These primary cutaneous CD30+ LCLs, lymphomatoid papulosis, and related conditions represent a clinical and histologic continuum. A classification with practical guidelines for the management and treatment of patients within this spectrum of lymphoproliferative disorders is presented.
Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands.
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Willemze
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Beljaards
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D006801:Humans; D017730:Ki-1 Antigen; D008223:Lymphoma; D016403:Lymphoma, Large B-Cell, Diffuse; D016410:Lymphoma, T-Cell, Cutaneous; D008232:Lymphoproliferative Disorders / Q000145:classification; D012878:Skin Neoplasms
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen