Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) and concurrent psychotropic drug administration.
Gilbert's Syndrome is a benign familial condition in which unconjugated hyperbilirubinemia occurs in the absence of structural liver disease or hemolysis. Phenothiazines and tricyclic medications are often withheld in patients with preexisting liver disease. The authors present four patients with Gilbert's Syndrome and concurrent psychiatric illness. Administration of phenothiazine antipsychotics or tricyclic antidepressants proved beneficial and produced no adverse effects on hepatic function. The authors discuss clinical aspects of Gilbert's Syndrome in psychiatric patients and conclude that phenothiazine antipsychotic medication should not necessarily be withheld from these patients.
Durst
R
R
Talbieh Mental Health Center, Jerusalem, Israel.
Jabotinsky-Rubin
K
K
Dorevitch
A
A
Kikinzon
L
L
Tur-Kaspa
R
R
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D005260:Female; D005476:Fluphenazine / Q000627:therapeutic use; D005878:Gilbert Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D010259:Paranoid Disorders / Q000150:complications / Q000188:drug therapy; D010640:Phenothiazines / Q000627:therapeutic use*; D012557:Schizoid Personality Disorder / Q000150:complications / Q000188:drug therapy
D000929:Antidepressive Agents, Tricyclic; D010640:Phenothiazines; D005476:Fluphenazine