Correlation between clinical staging (FIGO) and prognostic groups with gestational trophoblastic disease.
OBJECTIVE
To compare the Charing Cross Hospital scoring system with FIGO staging for gestational trophoblastic disease.


METHODS
A retrospective analysis of patients referred to Charing Cross during the period 1979-1989.


METHODS
National referral centre.


METHODS
Two hundred and seven women with gestational trophoblastic disease presenting between 1979-1989.


METHODS
The women were classified according to the Charing Cross Hospital scoring system and FIGO clinical staging and the results of treatment compared.


RESULTS
Of the 207 women studied, there were 102 low risk, 39 medium risk and 66 high risk according to the Charing Cross system and 26 stage 0, 83 stage 1, 23 stage 2, 51 stage 3 and 24 stage 4 according to the FIGO system. If the FIGO system had been used to determine therapy, 17 women would have been at risk of undertreatment and nine of overtreatment. The main prognostic factors contributing to a higher Charing Cross score and thus more intensive chemotherapy from the outset were: HCG > 10(5), interval from antecedent pregnancy > 12 months and term delivery.


CONCLUSIONS
The Charing Cross scoring system incorporates factors predictive of the presence of drug resistant tumour and thus allows more appropriate use of chemotherapy from the start of treatment than is possible with the anatomically based FIGO staging. Moreover, the system is easy to apply relying only on history and clinical examination in addition to a reliable quantitative HCG assay.
Department of Medical Oncology, Charing Cross Hospital, London, UK.
D B
DB
Smith
L
L
Holden
E S
ES
Newlands
K D
KD
Bagshawe
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014328:Trophoblastic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology*