Gonadal dysgerminoma-seminoma associated with severe hypercalcemia.
A case is reported, of a 25-year-old phenotypic female, karyotypic male patient with metastatic gonadal dysgerminoma-seminoma and severe hypercalcemic paraneoplastic syndrome. Patient manifested normal female external genitalia, vagina, uterus, and fallopian tubes but with 46 XY karyotype. Adnexal gonads were calcified. External beam radiation therapy resolved the hypercalcemic state. Exploratory laparotomy after irradiation revealed gonadoblastoma originating from dysgenetic gonads.
Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Y N
YN
Bakri
M
M
Akhtar
D000328:Adult; D012734:Disorders of Sex Development / Q000150:complications*; D004407:Dysgerminoma / Q000150:complications*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008297:Male; D010051:Ovarian Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010641:Phenotype; D013736:Testicular Neoplasms / Q000150:complications*