[Accuracy in estimating decompensation in type I diabetes].
Within the framework of a grant project the authors selected 30 patients, mean age 12.91 +/- 3.23 years with insulin dependent diabetes with a mean duration of 8 +/- 3.63 years treated so far by two doses of insulin per day: 0.49 +/- 0.21 UI/kg, ratio 3.1: 1.8 +/- 0.5: 0.3 rapid and NPH insulin, and an evening dose of 0.29 +/- 0.13 IU/kg with a ratio 2.4: 1.2 +/- 0.3: 0.2 rapid and NPH insulin, compensated on values of glycated haemoglobin HBA1c one month before assessment 6.31 +/- 1.84% and HBA1c at the time of assessment 7.52 +/- 2.13, with a residual capacity of the pancreas-C peptide values 0.70 +/- 0.20 ng/l. In this group the authors monitored, using a Biostator, the course of the 24-hour blood sugar level while the patients adhered to an individual dietary regime and insulin dosage. From the continual curve the authors selected with regard to time, typical peaks of the curve various types of profiles incl. those commonly used in practice. In those the authors compared the accuracy of calculation of compensation indexes. They found a different sensitivity of M-value, MGB a MAGE indexes, depending on the time of blood sampling used for their calculation and on the position of the selected blood sugar level in relation to the peaks of the blood sugar level. A significant finding was the marked influence on the accuracy of all indexes, but mainly of index MAGE, exerted by blood sugar levels associated with small meals and the nocturnal blood sugar level.(ABSTRACT TRUNCATED AT 250 WORDS)
Utĕsený
J
J
Výzkumný ústav zdraví dítĕte, Brno.
Hanák
R
R
D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008991:Monitoring, Physiologic
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin