Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex-linked recessive lethal assay.
Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex-linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4-8 micrograms ml-1 and 15-20 mg ml-1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant.
Letterman Army Institute of Research, San Francisco, CA 94129-6800.
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Gupta
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Korte
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Reddy
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D008040:Genetic Linkage; D006146:Guanidines / Q000633:toxicity*; D009152:Mutagenicity Tests; D009154:Mutation; D009604:Nitrosoguanidines / Q000633:toxicity*; D014960:X Chromosome / Q000187:drug effects*
D006146:Guanidines; D009604:Nitrosoguanidines; C056179:nitroguanidine