[The effect of a diet enriched with omega-3 polyunsaturated fatty acids on the indices of the blood fibrinolytic system in patients in the initial stages of ischemic heart disease].
The diet of 17 patients with coronary heart disease whose angina duration was no more than 5 months was daily supplemented by 6.15 g of omega 3-polyunsaturated fatty acids (PUFA) in 125 g of canned Far-Eastern sardine for 4 weeks. This resulted in increases of eucosapentaenic and docosahexaenic acids (from 1.28 +/- 0.72 to 9.02 +/- 2.83 and from 2.48 +/- 0.91 to 6.54 +/- 2.01%, respectively; p = 0.0003) in the total lipid fraction of serum. The proportion of omega 6-PUFA decreased at the expense of a decline in the levels of linoleic acid from 24.9 +/- 3.9 to 19.7 +/- 5.2% (p = 0.0014). Triglycerides fell from 162.3 +/- 55.2 to 103.9 +/- 42.4 mg/dl (p < 0.0005). The mean activity values of the tissue activator inhibitor plasminogen and C-protein, the levels of plasminogen, antithrombin III, and fibrinogen remained unchanged. The changes found in the tissue activator inhibitor plasminogen were associated with the baselines of lauric and myristic acids. Thus, a short-term fish diet which leads to profound changes in the fatty acid spectrum in blood and to favourable lipid shifts fails to cause profibrinolytic changes in parameters of the fibrinolytic system.
M V
MV
Pyzh
N A
NA
Gratsianskiĭ
A B
AB
Dobrovol'skiĭ
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000178:diet therapy; D001780:Blood Coagulation Tests; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005215:Fasting / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000178:diet therapy*; D005082:Physical Exertion; D013997:Time Factors
D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D008055:Lipids; D008074:Lipoproteins