[Portal blood levels of 5-FU administered intraperitoneally].
Portal blood levels of 5-FU were measured after intraperitoneal administration of 15 mg/kg of 5-FU in two patients who had a bypass operation for unresectable pancreatic cancer. The portal concentration of 5-FU increased rapidly. Tmax was 8-11 minutes and Cmax was 29-31 micrograms/ml. The peripheral blood levels followed the portal levels. Also, AUC of the portal levels seemed to be higher than the peripheral levels. The direct instillation of 5-FU into the peritoneal cavity might offer an alternative means of achieving higher regional drug levels, such as intraperitoneal and intraportal levels, without enhanced systemic toxicity.
Kakizaki
K
K
Dept. of Surgery, Sendai National Hospital.
Teshima
S
S
Yamauchi
H
H
D005472:Fluorouracil / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D010190:Pancreatic Neoplasms / Q000097:blood / Q000188:drug therapy; D011169:Portal Vein
D005472:Fluorouracil