Supraspinal mediation of dopamine-serotonin interactions in extrapyramidal motor functions in the rat.
The effects of intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administrated 8-OH-DPAT on catalepsy, induced by the specific DA D2 antagonist raclopride (16 mg kg-1 s.c.), were studied in rats. It was found that 8-OH-DPAT (0.5 or 2.0 micrograms kg-1) injected by the i.c.v. route produced a statistically significant of raclopride-induced catalepsy at both doses. In contrast, 8-OH-DPAT (0.2 or 2.0 micrograms kg-1) given by the i.t. route had no statistically significant effect on the raclopride-induced catalepsy. These results suggest that the antagonistic effect of 8-OH-DPAT on catalepsy, induced by DA blocking agents, is primarily mediated at the supraspinal level.
Department of Psychology, University of Stockholm, Sweden.
M L
ML
Wadenberg
V
V
Hillegaart
O G
OG
Berge
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D065127:Dopamine D2 Receptor Antagonists; D005116:Extrapyramidal Tracts / Q000166:cytology / Q000502:physiology*; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D020891:Raclopride; D051381:Rats; D017207:Rats, Sprague-Dawley; D012457:Salicylamides / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D065127:Dopamine D2 Receptor Antagonists; D012457:Salicylamides; D012701:Serotonin; D020891:Raclopride; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D004298:Dopamine