Signet-ring stromal tumor of the ovary: a histochemical, immunohistochemical and ultrastructural study.
We report a signet-ring stromal tumour found in the ovary of a 50-year-old woman. The solid tumour was composed of spindle and round cells which stained with vimentin and some round cells were vacuolated and had the appearance of signet-ring cells. The vacuoles were negative with periodic acid-Schiff, with and without diastase digestion, with alcian blue, Sudan III, alpha-1-antitrypsin and alpha-fetoprotein stains. Ultrastructurally, they were membrane bound and contained scantly flocculent material. Some neoplastic cells contained intracytoplasmic eosinophilic globules which were positive with alpha-1-antitrypsin. Signet-ring stromal tumour is a benign, morphologically distinctive type of ovarian stromal tumour, which may present problems in differential diagnosis with other stromal and non stromal ovarian neoplasms.
Departamento de Anatomía Patológica, Hospital La Paz, Madrid, Spain.
A
A
Suárez
J
J
Palacios
E
E
Burgos
C
C
Gamallo
D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis
D014746:Vimentin