Distribution of I, II and III subtypes of voltage-sensitive Na+ channel mRNA in the rat brain.
We examined the expression of the I, II and III subtypes of voltage-sensitive Na+ channel mRNA in the rat brain using in situ hybridization histochemistry with oligonucleotide probes. The distribution of cells with strongly positive signals was characteristic for each subtype. Synthesis of each subtype of Na+ channel protein may be regulated by differential mRNA expression.
First Department of Anatomy, Osaka City University Medical School, Japan.
T
T
Furuyama
Y
Y
Morita
S
S
Inagaki
H
H
Takagi
D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D001923:Brain Chemistry; D001933:Brain Stem / Q000737:chemistry / Q000648:ultrastructure; D006624:Hippocampus / Q000737:chemistry / Q000648:ultrastructure; D017403:In Situ Hybridization; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000737:chemistry; D015345:Oligonucleotide Probes; D016548:Prosencephalon / Q000737:chemistry / Q000648:ultrastructure; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D015222:Sodium Channels / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D015222:Sodium Channels