Biochemical modifications in the blood and the heated fluids during intraperitoneal chemohyperthermia.
The biochemical changes in blood during intraperitoneal chemohyperthermia (IPCH) were examined by carrying out complete assessments before and after the operation. These assessments were made up of 23 parameters: Na, K, Cl, CO2, urea, creatinine, proteins, glucose, calcium, phosphates, magnesium, bilirubin, uric acid, lactic acid, CRP, ASAT, ALAT, CK, LDH, gamma-GT, ALP, lipase, and amylase. Only 5 of these parameters showed significant changes: proteins, urea, ALP, gamma-GT, lactic acid. The protein and urea levels decreased due to hemodilution induced by the perfusion of fluids. ALP and gamma-GT levels decreased, possibly due to localized inhibition of secretion. Lactic acid levels increased due to the movement of lactates from the heated fluid into the blood. The study of biochemical changes within the heated fluids was made using the following parameters: CA 125, CA 19-9, CEA, ASAT, ALAT, CK, LDH, gamma-GT, ALP, lipase, uric acid, phosphates, proteins, Na, K, Cl, urea, creatinine, and magnesium. Between the beginning and the end of IPCH, significant increases were found in the levels of CA 125 (+173%), proteins (+190%), ASAT (+130%), LDH (+103%), K+ (+232%), PO4 (+134%), and uric acid (+99%). These increases indicate the existence of a significant degree of cellular lysis.
Department of Biochemistry, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
C
C
Berny
A
A
Mialon
M
M
Manchon
K E
KE
Le
G
G
Panteix
P
P
Baltassat
F N
FN
Gilly
P Y
PY
Carry
A
A
Sayag
G
G
Braillon
D000008:Abdominal Neoplasms / Q000097:blood* / Q000628:therapy; D000230:Adenocarcinoma / Q000097:blood / Q000628:therapy; D001826:Body Fluids / Q000737:chemistry; D001943:Breast Neoplasms / Q000097:blood / Q000628:therapy; D003110:Colonic Neoplasms / Q000097:blood / Q000628:therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007263:Infusions, Parenteral; D008654:Mesothelioma / Q000097:blood / Q000628:therapy; D008937:Mitomycins / Q000008:administration & dosage*; D010051:Ovarian Neoplasms / Q000097:blood / Q000628:therapy; D010865:Pilot Projects
D008937:Mitomycins