Indolinonic and quinolinic aminoxyls as protectants against oxidative stress.
A study on thermally and peroxyl radical induced oxidation of linolenic acid micelles in the presence of different concentrations of aminoxyls was carried out in order to test their efficiency as antioxidants in lipid peroxidation. The extent of peroxidation was measured by the malondialdehyde (MDA) produced and by oxygen consumption evaluated using an oxygraph. The results obtained indicate that indolinonic and quinolinic aminoxyls synthesized by us could be used as effective antioxidants in biological systems.
Academy of Physical Education, Department of Bioenergetics and Medical Academy, Gdansk, Poland.
J
J
Antosiewicz
E
E
Bertoli
E
E
Damiani
L
L
Greci
J
J
Popinigis
S
S
Przybylski
F
F
Tanfani
M
M
Wozniak
D000975:Antioxidants; D003497:Cyclic N-Oxides / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000494:pharmacology*; D008042:Linolenic Acids / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D008823:Micelles; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D011804:Quinolines / Q000494:pharmacology*
D000975:Antioxidants; D003497:Cyclic N-Oxides; D007211:Indoles; D008042:Linolenic Acids; D008823:Micelles; D011804:Quinolines; D008315:Malondialdehyde; C003959:TEMPO