Multiple genes for G protein-coupled receptors and their expression in lingual epithelia.
Using the polymerase chain reaction (PCR), we identified a gene family including more than 60 members which encoded similar G protein-coupled seven-transmembrane receptors. Sequence analyses of six representatives out of the 60 PCR clones showed that they had significant structural similarity to olfactory and optic receptors. Their expression is restricted in the surface of lingual epithelia.
Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan.
K
K
Abe
Y
Y
Kusakabe
K
K
Tanemura
Y
Y
Emori
S
S
Arai
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004848:Epithelium / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D015870:Gene Expression; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011956:Receptors, Cell Surface / Q000235:genetics*; D016415:Sequence Alignment; D013649:Taste / Q000502:physiology; D014059:Tongue / Q000502:physiology*
D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins