Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.
Anandamide (arachidonylethanolamide) is a brain constituent which binds to the cannabinoid receptor. We now report the first in vivo examination of this ligand. Anandamide administered i.p. in mice, caused lowering of activity in an immobility and in an open field test, and produced hypothermia and analgesia. These effects parallel those caused by psychotropic cannabinoids.
Fride
E
E
Department of Natural Products, Hebrew University, Pharmacy School, Jerusalem, Israel.
Mechoulam
R
R
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D001095:Arachidonic Acids; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry / Q000502:physiology*; D013759:Dronabinol / Q000494:pharmacology; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D053284:Polyunsaturated Alkamides; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000187:drug effects*; D013268:Stimulation, Chemical
D000577:Amides; D001095:Arachidonic Acids; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated; D053284:Polyunsaturated Alkamides; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D013759:Dronabinol; C078814:anandamide