Leuprolide acetate depot decreases the number of nucleolar organizer regions in uterine leiomyomata.
Women with symptomatic uterine myomas were randomized to receive LA depot or placebo for 12 weeks before myomectomy. Silver staining nucleolar organizer regions (AgNORs) per nuclei were assessed in the tissue obtained at the time of myomectomy. Myoma tissue from women treated with LA depot before myomectomy had significantly fewer AgNORs per nuclei than myoma tissue obtained from women treated with placebo. Leuprolide acetate depot may reduce the number of proliferating cells in myomas.
Department of Obstetrics and Gynecology, State University of New York at Stony Brook 11794-8091.
R L
RL
Barbieri
M
M
Dilena
J
J
Chumas
M S
MS
Rein
A J
AJ
Friedman
D000328:Adult; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000648:ultrastructure*; D016729:Leuprolide / Q000494:pharmacology*; D009697:Nucleolus Organizer Region / Q000187:drug effects*; D014594:Uterine Neoplasms / Q000097:blood / Q000648:ultrastructure*
D003692:Delayed-Action Preparations; D004958:Estradiol; D016729:Leuprolide