Estimation of vaccine efficacy from epidemics of acute infectious agents under vaccine-related heterogeneity.
A stochastic epidemic model is formulated for the study of the protective effects of vaccination in a population that is stratified by vaccine-related factors. The epidemic model is transformed into a counting process, and then martingale-based methods are used to provide estimators of vaccine efficacy and their variances. Following an example, various extensions of the model are discussed.
Division of Biostatistics, Emory University School of Public Health, Atlanta, Georgia.
I M
IM
Longini
M E
ME
Halloran
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M
Haber
D000208:Acute Disease; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000453:epidemiology*; D006801:Humans; D007114:Immunization; D008433:Mathematics; D015233:Models, Statistical; D014612:Vaccines
D014612:Vaccines