Early diagnosis of ectopic arginine vasopressin secretion.
We describe a patient who presented with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) 2 months before clinical evidence of bronchogenic malignancy. Because of the potential for the ectopic production of atrial natriuretic peptide (ANP) to mimic SIADH, both hormones were measured in this hyponatremic patient to seek a possible marker of tumor activity. A hypertonic saline infusion at presentation revealed excessive osmotically decoupled secretion of arginine vasopressin but a normal ANP response.
Coyle
S
S
Department of Chemical Pathology, St. James's University Hospital, Leeds, UK.
Penney
M D
MD
Masters
P W
PW
Walker
B E
BE
D000368:Aged; D001127:Arginine Vasopressin / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D018288:Carcinoma, Small Cell / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis*; D008297:Male; D012462:Saline Solution, Hypertonic
D012462:Saline Solution, Hypertonic; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor