The unstable melC operon of Streptomyces antibioticus is codeleted with a Tn4811-homologous locus.
The melC operon of Streptomyces antibioticus is unstable, undergoing frequent spontaneous deletions. All the delta melC mutants analyzed also lost 2-kb V1 DNA, which contained two open reading frames (ORFs) homologous to ORF4 (a putative oxidoreductase gene) and ORF5 (a putative AraC-type regulatory gene) of Tn4811. The two ORFs may constitute an accessory unit of a different transposon.
Institute of Genetics, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
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Yu
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Chen
D000595:Amino Acid Sequence; D001483:Base Sequence; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005784:Gene Amplification; D008543:Melanins / Q000235:genetics*; D008969:Molecular Sequence Data; D009876:Operon; D015183:Restriction Mapping; D017384:Sequence Deletion; D013303:Streptomyces antibioticus / Q000235:genetics*
D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D008543:Melanins