Are leukotrienes or PAF involved in hyperbaric oxygen toxicity?
Several very selective leukotriene inhibitors, and a PAF inhibitor, suitable for in vivo use, have been tested for their effects on hyperbaric oxygen toxicity. The leukotriene D4 inhibitor, L660771, and the 5-lipoxygenase pathway inhibitor L663536, failed to affect convulsions or lung damage induced by hyperbaric oxygen (pressure range 515-615 kPa) in either rats or mice. The specific PAF antagonist L659989 showed marginal protection against hyperoxic convulsions and did not alter pulmonary damage. The specific LTB4 antagonist SC-41930 was very effective in inhibiting hyperbaric oxygen-induced convulsions in both rats and mice. SC-41930 also very significantly protected rats against pulmonary oxygen toxicity, but had only marginally significant effects on pulmonary protection in mice.
School of Physiology and Pharmacology, University of New South Wales, Kensington, Australia.
Y
Y
Lin
D
D
Jamieson
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D005260:Female; D005663:Furans / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors; D015289:Leukotrienes / Q000502:physiology*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010100:Oxygen / Q000633:toxicity*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011312:Pressure; D011422:Propionates / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D013189:SRS-A / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D013047:Specific Pathogen-Free Organisms; D002722:Chlorobenzenes
D001578:Benzopyrans; D005663:Furans; D007211:Indoles; D007975:Leukotriene B4; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D010100:Oxygen; D010972:Platelet Activating Factor; D011422:Propionates; D011804:Quinolines; D013189:SRS-A; C060893:MK-886; D002722:Chlorobenzenes; C059950:SC 41930; C054893:L 659989; C059141:verlukast