[Jaccoud's type arthritis in a patient with unclassified connective tissue disease complicated with alveolar cell carcinoma].
The association between Jaccoud's type arthritis and systemic lupus erythematosus (SLE) is well recognized. Myositis, various arthropathy, and an assortment of miscellaneous connective tissue disorders have been described in association with malignancies. To date however Jaccoud's type arthritis has not been reported in unclassified connective tissue disease (UCTD) complicated with alveolar cell carcinoma (ACC). We describe a UCTD patient who presented LE cells, fluorescent antinuclear antibody (FANA), developing nonerosive, deforming arthritis and ACC. The case is a 59-year-old female who was admitted to our department in November, 1991 for exacerbated exertional dyspnea. She presented with UCTD of six years duration, characterized during follow-up by no history of rheumatic fever or Sjögren's syndrome, nor SLE. Five years later from onset of UCTD, her fingers developed a marked ulnar deviation, as well as pronounced swan-neck deformities. However, radiology did not show the marginal erosions of rheumatoid arthritis. A chest radiograph revealed a reticulogranular shadow in allover lung field, and a lung scintigram showed perfusion dominant mismatched defect in bilateral lower lung field. A transbronchial lung biopsy of B8a was diagnostic for ACC.
Second Department of Internal Medicine, Saitama Medical School.
M
M
Tanaka
T
T
Suzuki
T
T
Katagiri
T
T
Asaoka
H
H
Kiuchi
Y
Y
Dohi
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000150:complications* / Q000473:pathology; D001168:Arthritis / Q000150:complications*; D003240:Connective Tissue Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D008875:Middle Aged