Molecular mechanisms involved in catecholamine regulation of sodium transport.
The catecholamines dopamine and norepinephrine, play a central role in the regulation of sodium homeostasis and blood pressure. Dopamine inhibits tubular Na+, K(+)-ATPase activity and increases sodium excretion. Norepinephrine stimulates Na+, K(+)-ATPase activity and decreases urinary sodium excretion. The signaling pathway by which these two opposite first messengers regulate Na+, K(+)-ATPase activity involves the dopamine-specific protein phosphatase-1 inhibitor, DARPP-32, and the norepinephrine-activated protein phosphatase-2B, calcineurin. Aberrations in the renal dopamine/norepinephrine system may be the cause of alterations in the regulation of sodium excretion during ontogeny and in salt-sensitive hypertension.
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
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Meister
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Aperia
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000096:biosynthesis; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D006801:Humans; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010750:Phosphoproteins; D011941:Receptors, Adrenergic / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002395:Catecholamines; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine