Antagonistic modulation of human cytomegalovirus replication by transforming growth factor beta and basic fibroblastic growth factor.
We studied the effect of two cytokines, basic fibroblastic growth factor (bFGF) and transforming growth factor beta (TGF-beta) on human cytomegalovirus (HCMV) replication in cultured human lung fibroblasts. We show that TGF-beta increases HCMV production, probably by a transcriptional mechanism, and that bFGF represses HCMV replication in a dose-dependent manner. These actions were antagonistic and the mechanisms involved were independent of the effects of these factors on cell DNA synthesis and proliferation.
Unité d'Immunologie Virale, Institut Pasteur, Paris, France.
J
J
Alcami
C V
CV
Paya
J L
JL
Virelizier
S
S
Michelson
D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000187:drug effects; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D005347:Fibroblasts; D006801:Humans; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects* / Q000235:genetics
D004279:DNA, Viral; D016212:Transforming Growth Factor beta; D016222:Fibroblast Growth Factor 2