Kinetics of relaxation responses to vasorelaxants in intact and adventitia- and endothelium-denuded isolated rabbit thoracic aorta.
1. Although the relaxation responses to 5'-N-ethylcarboxamidoadenosine and sodium nitroprusside were stable, the relaxation response to isoproterenol partially desensitized as was observed by the partial regaining of tissue tension. 2. The apparent rate constant for relaxation by all three vasorelaxants was decreased in the presence of the adventitia and endothelium. 3. The magnitude of the relaxation responses for all three vasorelaxants and the apparent rate constant for isoproterenol desensitization were similar in intact and denuded tissues.
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John's University, Jamaica, NY 11439.
H L
HL
Wiener
F A
FA
Sehba
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D006152:Cyclic GMP / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011817:Rabbits; D014665:Vasodilator Agents / Q000493:pharmacokinetics / Q000494:pharmacology*
D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine; D019830:Adenosine-5'-(N-ethylcarboxamide); D006152:Cyclic GMP; D000241:Adenosine