The effect of casein phosphopeptides on calcium utilization in young ovariectomized rats.
The effect of casein phosphopeptides (CPPs) on Ca utilization in ovariectomized (OVX) rats was studied. A mixture of CPPs corresponding to the amino acid sequences 1-25 and 1-28 in the beta-casein was isolated from the tryptic digest of beta-casein (beta CPP). After being fed a low Ca diet for 30 days, OVX rats were fed experimental diets of which the Ca level was 0.1%, 0.3% or 0.5% with or without 0.15% beta CPP for 28 days. During days 1-3 of the Ca refeeding period, rats fed beta CPP with 0.5% Ca showed a higher Ca absorption than control rats not supplemented with beta CPP. During days 7-9 and 26-28, there were no significant differences in Ca and P balances between the beta CPP group and the control group for each dietary Ca level. Femoral Ca and P contents from rats fed beta CPP tended to be higher than those from control rats. These results suggest that beta CPP supplementation could have an effect on Ca absorption at a certain degree of Ca deficiency.
Central Research Institute, Meiji Milk Products Co., Ltd., Higashimurayamashi, Japan.
H
H
Tsuchita
I
I
Sekiguchi
T
T
Kuwata
C
C
Igarashi
I
I
Ezawa
D000042:Absorption; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D015519:Bone Density; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D002364:Caseins / Q000737:chemistry / Q000494:pharmacology*; D004063:Digestion; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects; D005260:Female; D005269:Femur / Q000737:chemistry; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000378:metabolism*; D010052:Ovariectomy; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D010748:Phosphopeptides / Q000737:chemistry / Q000494:pharmacology*; D016226:Phosphorus, Dietary / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects
D000596:Amino Acids; D002136:Calcium, Dietary; D002364:Caseins; D010446:Peptide Fragments; D010748:Phosphopeptides; D016226:Phosphorus, Dietary