Oculogyric crisis possibly related to pentazocine.
OBJECTIVE
To report and describe the apparent first case of acute oculogyric crisis following administration of pentazocine, and to discuss the possible mechanism for this reaction.
Patient case and relevant review of literature. The patient, a 39-year-old woman, developed acute oculogyric crisis following administration of Talacen (pentazocine and acetaminophen) for pain relief. The crisis resolved after discontinuation of the medication and administration of intravenous diphenhydramine 50 mg.


CONCLUSIONS
Based on the temporal relationship of drug administration to occurrence of the event, pentazocine is implicated as the cause of this acute oculogyric crisis. A plausible mechanism for precipitation of this crisis is the agonism of pentazocine on sigma opiate receptors, with postulated subsequent modulation of dopamine receptors.
Burstein
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AH
Division of Neuropharmacology, Dent Neurologic Institute, Millard Fillmore Hospital, Buffalo, NY 14209.
Fullerton
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D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D015835:Ocular Motility Disorders / Q000139:chemically induced*; D010423:Pentazocine / Q000009:adverse effects* / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects
D011957:Receptors, Opioid; D010423:Pentazocine