[Modification of ischemia and reperfusion damage of skeletal muscles with allopurinol: in vivo 31P MR spectroscopy of the posterior limb of the rat].
The effect of Allopurinol on energy metabolism (re-utilisation of hypoxanthine) was studied in a in vivo skeletal muscle ischemia rat model by 31-P-MR spectroscopy. Allopurinol-treatment showed no benefit to the kinetics of PCr/(Pi + PCr) and ATP/(Pi + PCr). The role of re-utilisation of hypoxanthine has to be further investigated.
Department Chirurgie, Kantonsspital, Universität Basel.
L
L
Gürke
A
A
Marx
P
P
Erhard
P M
PM
Sutter
J
J
Landmann
M
M
Heberer
D000255:Adenosine Triphosphate / Q000378:metabolism; D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D006614:Hindlimb / Q000294:innervation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009132:Muscles / Q000098:blood supply*; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism*
D010710:Phosphates; D010725:Phosphocreatine; D000493:Allopurinol; D000255:Adenosine Triphosphate