Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell.
A cDNA clone encoding bone morphogenetic protein 4 (BMP 4) has been isolated from a primary fetal rat calvarial cell cDNA library. Sequencing of this clone has revealed a single open reading frame encoding a 408 amino acid protein. Comparison of 5' noncoding exon 1 portion of this cDNA with that of human bone and prostate BMP4 cDNA shows that BMP4 gene expression may possess tissue specificity.
University of Texas Health Science Center at San Antonio 78284-7877.
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Chen
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Feng
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Feng
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Harris
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Mundy
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Harris
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins; D001859:Bone Neoplasms / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002460:Cell Line; D003001:Cloning, Molecular; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats
D019485:Bone Morphogenetic Proteins; D011506:Proteins; D012333:RNA, Messenger