Prospective randomized study of piperacillin/tazobactam therapy of surgically treated intra-abdominal infection. The Piperacillin/Tazobactam Intra-Abdominal Infection Study Group.
A randomized prospective trial was undertaken in adult patients with serious intra-abdominal infections to determine whether a new combination of antibiotic therapy could prove as efficacious as the combination that has been widely used in practice in the recent decade (clindamycin and gentamicin). Three hundred thirty-one patients were randomized in a 2:1 ratio, with the larger number of patients being treated parenterally with piperacillin and tazobactam. The results showed that both the clinical and microbiologic performance of the piperacillin/tazobactam combination was better than that of clindamycin and gentamicin. This clinical equivalence permits overall cost savings without compromising the existing quality of antimicrobial therapy for intra-abdominal infection.
Polk
H C
HC
University of Louisville School of Medicine, Kentucky.
Fink
M P
MP
Laverdiere
M
M
Wilson
S E
SE
Garber
G E
GE
Barie
P S
PS
Hebert
J C
JC
Cheadle
W G
WG
D000005:Abdomen; D000038:Abscess / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001064:Appendicitis / Q000188:drug therapy; D001424:Bacterial Infections / Q000188:drug therapy* / Q000601:surgery*; D002761:Cholangitis / Q000188:drug therapy; D002764:Cholecystitis / Q000188:drug therapy; D002981:Clindamycin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004238:Diverticulitis / Q000188:drug therapy; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000008:administration & dosage; D010538:Peritonitis / Q000188:drug therapy; D010878:Piperacillin / Q000008:administration & dosage; D011446:Prospective Studies; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
D005839:Gentamicins; D065093:beta-Lactamase Inhibitors; D002981:Clindamycin; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin