Synthesis of epoxypropyloxy chromones and allyl hydroxy chromones and in vitro-in vivo activity on protoscoleces of Echinococcus multilocularis (Cestoda).
Derivatives with epoxypropyloxy, allyloxy and allyl hydroxychromone structures were synthesized and tested against protoscoleces of Echinococcus multilocularis. Compounds IV-IX were tested in vitro and compound VII proved the most active of them with, at 0.1 mmol.L-1, 98% dead protoscoleces in open vesicles after 24 hours and 80% in closed vesicles within 96 hours. Compound VII was tested in vivo on Meriones unguiculatus infested by Echinococcus multilocularis, but was found to be rather inactive.
Haddad
B
B
Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille II 3, France.
Bethegnies
G
G
Marcincal-Lefebvre
A
A
Duriez
T
T
Afchain
D
D
Thuillier
P
P
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004443:Echinococcosis / Q000188:drug therapy* / Q000469:parasitology; D004446:Echinococcus / Q000187:drug effects*; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005849:Gerbillinae; D007814:Larva / Q000187:drug effects; D008297:Male; D051379:Mice
D000871:Anthelmintics; D002867:Chromones; D004852:Epoxy Compounds