Dendritic cells are potent antigen-presenting cells for microbial superantigen.
Dendritic cells (DC) were found to be more efficient than macrophages (MO) in activating T cell responses to Staphylococcal enterotoxin B (SEB) using the hanging drop techniques and DC as antigen presenting cells (APC). When superantigen was presented via DC, the activation of T cells was not dependent on antigen processing and MHC class II molecules IA and IE were involved.
Antigen Presentation Research Group, Clinical Research Centre, Harrow, Middlesex.
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Iqball
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Bhatt
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Bedford
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Borriello
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Knight
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000378:metabolism; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D004768:Enterotoxins / Q000276:immunology* / Q000378:metabolism; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology / Q000378:metabolism; D011108:Polymers / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology
D000942:Antigens, Bacterial; D004768:Enterotoxins; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D011108:Polymers; D005557:Formaldehyde; C031818:enterotoxin B, staphylococcal; C003043:paraform