The visualization of gastroenteropancreatic endocrine tumors.
In this review, we evaluate radiological techniques currently used to localize gastroenteropancreatic (GEP) endocrine tumors. We also describe the visualization, using intravenous administration of two isotope-labelled somatostatin analogs (123-I-Tyr3-octreotide and 111In-DTPA-octreotide), of islet cell tumors in 25 patients and carcinoids in 39 patients. The primary tumor as well as previously unrecognized distant metastases were visualized in 20 of the 25 patients (80%) and in 37 of the 39 (95%). Parallel in vitro detection of somatostatin receptors on those tumors also visualized in vivo showed that ligand binding to the tumor in vivo represents binding to specific somatostatin receptors. The detection of somatostatin receptors on tumors in vivo predicted a good suppressive effect of octreotide on hormonal hypersecretion by these tumors. It is an easy, quick and harmless procedure, valuable in the localization of primary endocrine pancreatic tumors and their often radiologically and clinically unrecognized metastases. Future prospective controlled studies comparing this procedure with other radiological investigative techniques should demonstrate its sensitivity and specificity and determine the place of somatostatin receptor imaging in the localization of GEP endocrine tumors.
Department of Medicine, Erasmus University, Rotterdam, The Netherlands.
S W
SW
Lamberts
J A
JA
Chayvialle
E P
EP
Krenning
D007516:Adenoma, Islet Cell / Q000737:chemistry / Q000175:diagnosis*; D002276:Carcinoid Tumor / Q000737:chemistry / Q000175:diagnosis; D003952:Diagnostic Imaging; D005770:Gastrointestinal Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D015282:Octreotide / Q000031:analogs & derivatives; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D004369:Pentetic Acid / Q000031:analogs & derivatives; D017481:Receptors, Somatostatin / Q000032:analysis
D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D017481:Receptors, Somatostatin; C045210:3-Tyr-octreotide; C071632:SDZ 215-811; D004369:Pentetic Acid; D015282:Octreotide