Impairment of baroreceptor reflexes following kainic acid lesions of the lateral tegmental field.
We examined the effects of kainic acid lesions of the lateral tegmental field on baroreceptor function in the anesthetized cat. Kainic acid lesions prevented the reflex inhibition of inferior cardiac sympathetic nerve activity observed during an increase in blood pressure. The temporal locking of sympathetic slow waves to the cardiac cycle was also abolished following tegmental field lesions. Finally, the periodicity of sympathetic nerve discharge shifted to a higher frequency range following kainic acid lesions. These observations are consistent with the conclusion that lesions of the lateral tegmental field impair baroreceptor reflexes.
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Upjohn Co., Kalamazoo, MI 49001.
McCall
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002415:Cats; D003714:Denervation; D004058:Diffusion; D007608:Kainic Acid / Q000008:administration & dosage / Q000633:toxicity*; D008526:Medulla Oblongata / Q000166:cytology / Q000502:physiology; D008845:Microinjections; D010525:Peripheral Nerves / Q000502:physiology; D011311:Pressoreceptors / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology; D013681:Tegmentum Mesencephali / Q000187:drug effects / Q000502:physiology*
D007608:Kainic Acid