Free radical production during photo-assisted NADPH reduction of four alpha-nitroarenofurans.
Generation of radical anions during NADPH reduction of four mutagenic and genotoxic alpha-nitroarenofurans was examined. ESR showed that free radicals were generated during reduction solely in the presence of light. Computer simulations of ESR spectra were in good agreement with the experimental ones.
Laboratoire de Réactivité de Surface et Structure, URA 1106 CNRS, Université Pierre et Marie Curie, Paris, France.
R
R
Zalma
H
H
Strapelias
O
O
Chalvet
J P
JP
Buisson
H
H
Pezerat
P
P
Demerseman
M
M
Duquesne
D001572:Benzofurans / Q000737:chemistry / Q000378:metabolism; D003198:Computer Simulation; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D005663:Furans / Q000737:chemistry / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D009581:Nitrofurans / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D010777:Photochemistry
D001572:Benzofurans; D005609:Free Radicals; D005663:Furans; D009153:Mutagens; D009581:Nitrofurans; C036334:2-nitrobenzofuran; D009249:NADP; C053501:2-nitronaphtho(2,1-b)furan