Gonadal function in men with testicular germ cell cancer: the influence of cisplatin-based chemotherapy.
Exocrine and endocrine gonadal function is abnormal in some of the testicular cancer patients who have been treated with orchidectomy alone and receive no cytotoxic treatment. A review of the literature reveals that cisplatin-based chemotherapy seems to induce additional long-term damage to spermatogenesis and Leydig cell function. Most patients regain active spermatogenesis after chemotherapy, whereas subclinical Leydig cell dysfunction persists. In order to elucidate whether the cisplatin-induced gonadal toxicity has clinical implications, observation periods exceeding those previously reported are required.
Danish Cancer Society, Department of Experimental Clinical Oncology, Arhus.
P V
PV
Hansen
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Hansen
D000293:Adolescent; D000328:Adult; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007985:Leydig Cells / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000503:physiopathology; D013091:Spermatogenesis / Q000187:drug effects*; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
D002945:Cisplatin