Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters.
Gonadotropin-releasing hormone analogs (GnRH-A) have been added to the armentarium in the therapy of hormone-dependent breast cancer in premenopausal women. The effect of chronic GnRH-A-treatment in premenopausal women is based on the suppression of the hypothalamus-pituitary-ovarian axis and the reduction of sex-steroid serum levels. In addition, a number of experimental and clinical data have been accumulated indicating a direct action of GnRH-A on breast cancer cells and tissue. In this study we analyzed 235 human breast cancer biopsies for specific GnRH-A-binding. We demonstrate high affinity GnRH-A binding sites in human breast cancer tissues. The evaluation of clinical data showed no correlation of the level of GnRH-A-binding with classical tumor parameters.
Department of Gynaecology and Obstetrics, University of Heidelberg, Germany.
K H
KH
Baumann
L
L
Kiesel
M
M
Kaufmann
G
G
Bastert
B
B
Runnebaum
D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive / Q000502:physiology; D001706:Biopsy; D001943:Breast Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D002064:Buserelin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000378:metabolism; D011966:Receptors, LHRH / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism; D016196:S Phase / Q000502:physiology
D011960:Receptors, Estrogen; D011966:Receptors, LHRH; D011980:Receptors, Progesterone; C081829:buserelin receptor; D002064:Buserelin