Comparative effects of gold on the interactions of transcription factors with DNA.
We have previously hypothesized that a mode of action of the anti-rheumatic gold salt, aurothiomalate (AuTM), is the inhibition of DNA binding by transcription factors. Studies of the progesterone receptor (PR), which has a zinc finger structure in the DNA binding domain, were consistent with this hypothesis (1). Here we show that AuTM also markedly inhibits DNA binding by the transcription factor AP-1 and has less potent effects for AP-2, NF-1 and TFIID.
Handel
M L
ML
Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, Australia.
Sivertsen
S
S
Watts
C K
CK
Day
R O
RO
Sutherland
R L
RL
D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000187:drug effects*; D006052:Gold Sodium Thiomalate / Q000494:pharmacology*; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D006052:Gold Sodium Thiomalate