Alterations in human lung adrenergic receptors in cancer.
Data on human lung alpha 1- and beta-adrenoceptors and the alpha 1/beta adrenergic ratio in cancer and chronic inflammatory processes are reported. The number of alpha 1-adrenergic sites markedly increased in lung cancer parenchyma, giving a ratio of alpha 1/beta binding sites of 12/1 in cancer but almost 1:1 in control specimens. The alpha 1/beta adrenergic ratio obtained both for mild and severe chronic pneumonia and tuberculosis lung parenchyma was similar to that demonstrated for normal tissue. The above findings suggest the cancer-induced enhancement in parenchymal alpha 1-adrenergic activity.
Research Center of Molecular Diagnostics and Therapy, Moscow, Russia.
T Y
TY
Kondratenko
I V
IV
Zacharova
N V
NV
Kuzina
Katukov VYu
E S
ES
Severin
Z Ch
ZCh
Kornilova
M I
MI
Perelman
D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D001665:Binding Sites; D002908:Chronic Disease; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000378:metabolism; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta