Successful treatment of simultaneous pulmonary Pseudallescheria boydii and Aspergillus terreus infection with oral itraconazole.
Pseudallescheria boydii and Aspergillus terreus are unusual opportunistic fungal pathogens that are often resistant to chemotherapy with amphotericin B. We report a case of simultaneous invasive pulmonary infection with these organisms occurring in a bone marrow transplant recipient who was successfully treated with the oral azole itraconazole.
Goldberg
S L
SL
Bone Marrow Transplant Program, Temple University Comprehensive Cancer Center, Philadelphia, Pennsylvania.
Geha
D J
DJ
Marshall
W F
WF
Inwards
D J
DJ
Hoagland
H C
HC
D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D001230:Aspergillus / Q000187:drug effects; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology; D003646:Debridement; D006086:Graft vs Host Disease / Q000150:complications / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008168:Lung / Q000000981:diagnostic imaging / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D008297:Male; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D011541:Pseudallescheria / Q000187:drug effects; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole