Zirconocene complexes of unsaturated organic molecules: new vehicles for organic synthesis.
Transition metals are known to stabilize high-energy species and to activate otherwise unreactive ones. The zirconocene unit stabilizes highly strained alkynes and alkenes, allowing their use in selective carbon-carbon bond-forming reactions. This unit also increases the reactivity of unactivated molecules, enabling them to participate in nontraditional transformations. A general route has been developed that allows a wider variety of unsaturated fragments to participate in these reactions. The use of these zirconocene complexes in organic synthesis has led to the development of novel routes to a number of polyfunctionalized organic molecules.
Broene
R D
RD
Department of Chemistry, Massachusetts Insitute of Technology, Cambridge 02139.
Buchwald
S L
SL
D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
D009942:Organometallic Compounds; D015040:Zirconium