[Chemical-physical compatibility of thiocolchicoside and nonsteroidal anti-inflammatory drugs].
The combined therapy requires the knowledge of possible interactions between the drugs used. In the case of parenteral formulations the physiochemical stability must be preliminarily verified in an extemporary mixture. The study protocol should be able to make evident possible variations of the main physicochemical parameters at room temperature and in stress conditions. Examples of drug-drug interactions are taken from literature to better define the issue of compatibility in solution. The results of an experimental study between an injectable thiocolchicoside, a well-known miorelaxants and some non-steroidal antiinflammatory drugs are also reported.
Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano.
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Pifferi
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003078:Colchicine / Q000031:analogs & derivatives* / Q000737:chemistry; D004344:Drug Incompatibility; D009125:Muscle Relaxants, Central / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009125:Muscle Relaxants, Central; D003078:Colchicine; C004280:thiocolchicoside