Introduction: protein phosphorylation and signal transduction in bacteria.
A single type of reversible protein-phosphorylating system, the ATP-dependent protein kinase/phosphatase system, is employed in signal transduction in eukaryotes. By contrast, recent work has revealed that three types of protein-phosphorylating systems mediate signal transduction in bacteria. These systems are (1) classical protein kinase/phosphatase systems, (2) sensor-kinase/response-regulator systems, and (3) the multifaceted phosphoenolpyruvate-dependent phosphotransferase system. Physiological, structural, and mechanistic aspects of these three evolutionarily distinct systems are discussed in the papers of this written symposium.
Department of Biology, University of California at San Diego, La Jolla 92093-0116.
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Saier
D000255:Adenosine Triphosphate / Q000378:metabolism; D000494:Allosteric Regulation; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000378:metabolism*; D008954:Models, Biological; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
D001426:Bacterial Proteins; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; D010749:Phosphoprotein Phosphatases