Analysis of genetic variability of populations of herpes simplex viruses.
An analysis of genetic variability of herpes simplex virus type 1 and type 2 populations of the Madrid (Spain) area has been carried out by digestion of viral DNA with restriction endonucleases. The index of nucleotide diversity indicated that herpes simplex virus type 1 has a slightly, although statistically significant, higher degree of heterogeneity than type 2. A phylogenetic tree for each type of virus has been constructed. The evolutionary pattern followed by both types of viruses ('star-like' topology) suggest that all the isolates analyzed evolved from a unique origin for each type of virus.
Centro Nacional de Biología Celular y Retrovirus, Instituto de Salud Carlos III, Madrid, Spain.
J M
JM
Rojas
J
J
Dopazo
E
E
Martín-Blanco
C
C
López-Galíndez
E
E
Tabarés
D000818:Animals; D005814:Genes, Viral; D014644:Genetic Variation; D010802:Phylogeny; D015183:Restriction Mapping; D018139:Simplexvirus / Q000145:classification / Q000235:genetics*; D014709:Vero Cells