Pharmacokinetic considerations in critical care.
As an applied science, pharmacokinetics permits the clinician to predict serum drug concentrations (SDCs) and associated pharmacologic responses, estimate dosage requirements, and assess unexpected drug responses. Therapeutic drug monitoring operationalizes the principles of pharmacokinetics through a multidisciplinary approach to the assessment and application of patient SDC data. Complicating the assessment of patients receiving these drugs is the tendency for physiologic changes and drug interactions to influence SDCs and associated pharmacologic responses. In determining the best dosing regimen for a particular patient, it is important to consider factors such as age, weight, major organ function, and concurrent drugs and disease states.
Reynolds
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JR
D000367:Age Factors; D001835:Body Weight; D015897:Comorbidity; D003422:Critical Care; D004334:Drug Administration Schedule; D004347:Drug Interactions; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D006801:Humans; D010348:Patient Care Team; D010599:Pharmacokinetics