Reduction of reperfusion injury by recombinant human superoxide dismutase administered intravenously just prior to reperfusion.
The reduction of reperfusion injury by intravenous administration of recombinant human superoxide dismutase (r-hSOD) was evaluated in a dog model. Two hours of left anterior coronary artery clamping were followed by 30 min of partial reperfusion and 30 min of full reperfusion. In the SOD group, r-hSOD (100,000 U/kg) was given intravenously 5 min before reperfusion. Measured left ventricular (LV) segments were classified thermographically by temperature drop into central (> or = 2 degrees C) and marginal (< 2 degrees C) areas. The regional LV functions were evaluated by percentages of both segmental (%SS) and active (%AS) shortening. In the central area, the %SS values after reperfusion were -9% in the control group and -3% in the SOD group (p < 0.05). The respective %AS values were 6 and 29% (p < 0.01). In the marginal area, both groups had %SS values of -3% and respective %AS values of 34 and 22% (all not significant) after reperfusion. In the central area, there was significantly better LV function recovery in the SOD group than in the control group.
First Department of Surgery, Saitama Medical School, Japan.
K
K
Neya
S
S
Takamoto
K
K
Morita
T
T
Matsuda
S
S
Kyo
Y
Y
Yokote
R
R
Omoto
D000818:Animals; D004285:Dogs; D007262:Infusions, Intravenous; D015425:Myocardial Reperfusion / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D013997:Time Factors
D011994:Recombinant Proteins; D013482:Superoxide Dismutase