Inhibitory effects of 3-nitrophloroglucinecarboxylic acid derivatives on Epstein-Barr virus early antigen induction.
The inhibitory effects of two series of 3-nitrophloroglucinecarboxylic acid derivatives, 3-nitro-2,4,6-trihydroxythiobenzamides (II) and 3-nitro-phloroglucinecarboxylates (III), on Epstein-Barr virus early antigen (EBV-EA) induction were examined using Raji cells. Some of them strongly inhibited the induction, N-nonyl and O-decyl derivatives being the most potent inhibitors among the thioamides and esters, respectively. These results suggest the possibility that these two 3-nitrophloroglucinecarboxylic acid derivatives may be listed as novel inhibitors of tumor promotion.
Life Science Research Laboratory, Japan Tobacco Inc., Yokohama.
I
I
Honda
H
H
Tokuda
M
M
Kozuka
K
K
Yoneyama
H
H
Nishino
A
A
Iwashima
M
M
Shibagaki
M
M
Noma
N
N
Takahashi
S
S
Yoshida
D000956:Antigens, Viral / Q000096:biosynthesis / Q000187:drug effects*; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000276:immunology; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D010696:Phloroglucinol