A minute deletion of the Y chromosome in men with azoospermia.
We analyzed deoxyribonucleic acid from 50 Japanese men with azoospermia whose Y chromosomes were cytogenetically normal. A total of 26 loci was examined in each patient. Of these patients 6 had small interstitial deletions, each of which was located within the distal part of Yq11. Five of these 6 patients lacked the same 2 loci, DYS7C and DYS1, while 1 patient had a larger deletion including DYS7C but not DYS1. More than 10% of all men with azoospermia of unknown origin may have minute interstitial deletions of the Y chromosome surrounding the DYS7C locus. The proximal part of this zone presumably encompasses the gene deletion that causes azoospermia.
Nagafuchi
S
S
Department of Human Genetics, School of International Health, University of Tokyo, Japan.
Namiki
M
M
Nakahori
Y
Y
Kondoh
N
N
Okuyama
A
A
Nakagome
Y
Y
D000328:Adult; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D014998:Y Chromosome / Q000648:ultrastructure*
D004247:DNA