Influence of lisinopril on urinary electrolytes excretion after furosemide in healthy subjects.
It has been reported that the urinary excretions of chloride (Cl), potassium (K), and magnesium (Mg), but not sodium (Na), after furosemide, a loop diuretic, were decreased by pretreatment with lisinopril, an ACE inhibitor in hypertensive subjects. The electrolytes disturbance induced by furosemide might be ameliorated by lisinopril. The present study re-examines this potential drug interaction in healthy subjects. Lisinopril (20 mg) or its matching placebo was given orally using a double-blind, crossover design. Four hours after lisinopril administration, furosemide (20 mg) was injected intravenously and urine was collected during the following intervals: 0-0.5, 0.5-1, 1-1.5, 1.5-2, 2-3, 3-4, and 4-6 hours. Blood samples for plasma furosemide concentration were obtained at 0.5, 1, 1.5, 2, 3, 4, and 6 hours after the agent. There were no significant differences between the two trials in plasma concentrations of furosemide or urinary excretions of the agent. Urine volume and urinary excretions of electrolytes (Na, Cl, K, and Mg) after the furosemide with lisinopril administration were not significantly different from those of placebo at any observation period. These results suggest that the urinary excretions of electrolytes after furosemide administration are not influenced by pretreatment with lisinopril.
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
T
T
Sudoh
A
A
Fujimura
T
T
Shiga
T
T
Tateishi
K
K
Sunaga
K
K
Ohashi
A
A
Ebihara
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D004311:Double-Blind Method; D004347:Drug Interactions; D004573:Electrolytes / Q000652:urine*; D005665:Furosemide / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D017706:Lisinopril; D008297:Male; D011292:Premedication; D012083:Renin / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D004573:Electrolytes; D005665:Furosemide; D017706:Lisinopril; D012083:Renin