Accessory subunits and sodium channel inactivation.
Recent studies have shown that the accessory subunits of the voltage-gated sodium channel can modify its inactivation properties. Other studies have demonstrated that the cytoplasmic linker between domains III and IV is critical for fast inactivation. Future work should help to define the mechanisms by which these processes occur, and how mutations affecting sodium channel inactivation result in human neurological diseases.
Department of Microbiology and Molecular Genetics, University of California, Irvine 92717-4025.
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D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D008969:Molecular Sequence Data; D015222:Sodium Channels / Q000502:physiology*
D015222:Sodium Channels