Effect of pentoxifylline on sperm motion.
The ability of pentoxifylline to stimulate sperm motility characteristics was assessed. The effect of pentoxifylline was immediate and lasted for 240 min. The percent motility was increased 1.5-fold when compared with the control at 120, 180, and 240 min after pentoxifylline treatment. Significant increases in velocity and amplitude of lateral head displacement by the agent were observed at 120 min after the start of incubation. Conversely, linearity was reduced by pentoxifylline. Beat-cross frequency did not show any significant change by the agent at any time point. Sperm swelling was not influenced by pentoxifylline throughout the experiment. It would appear that pentoxifylline stimulates sperm motion in vitro with no change of the sperm membrane.
Fuse
H
H
Department of Urology, Toyama Medical and Pharmaceutical University, Japan.
Sakamoto
M
M
Ohta
S
S
Katayama
T
T
D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D012815:Signal Processing, Computer-Assisted; D013081:Sperm Motility / Q000187:drug effects*
D010431:Pentoxifylline