[A new antileukemic drug, cytarabine ocfosfate].
Cytarabine ocfosfate (commercial name: Starasid) is a prodrug having stearyl group attached to phosphoric acid at 5' position of arabinose moiety of cytosine arabinoside (Ara-C). This drug is given orally. The mode of action is in the inhibition of DNA synthesis after conversion to Ara-CTP as in Ara-C. The drug is metabolized in the liver, producing the intermediate metabolite, C-C3PCA which is converted to Ara-C gradually. This property results in the maintenance of relatively long time the blood Ara-C levels. This was proved to be active clinically against acute leukemia and MDS.
Tsukagoshi
S
S
Cancer Chemotherapy Center, Japanese Foundation Cancer Research.
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D001088:Arabinonucleotides / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D003568:Cytidine Monophosphate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D004285:Dogs; D005260:Female; D006801:Humans; D007942:Leukemia, Experimental / Q000188:drug therapy; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D011355:Prodrugs / Q000008:administration & dosage*; D051381:Rats; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001088:Arabinonucleotides; D011355:Prodrugs; C061162:1-arabinofuranosylcytosine-5'-stearylphosphate; D003568:Cytidine Monophosphate