Role of cyclic GMP in airway smooth muscle relaxation.
The evidence in favor of a role for cyclic GMP as a mediator of relaxation in airway smooth muscle is reviewed. All of the criteria usually used to decide whether a cyclic nucleotide is the mediator of a particular response appear to have been satisfied, at least to some extent, for a causal relationship between cyclic GMP elevation and relaxation of airway smooth muscle.
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
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D000818:Animals; D006152:Cyclic GMP / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D009126:Muscle Relaxation / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology; D012143:Respiratory Physiological Phenomena
D011494:Protein Kinases; D006152:Cyclic GMP