A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists.
Portoghese
P S
PS
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Moe
S T
ST
Takemori
A E
AE
D000818:Animals; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D010111:Oxymorphone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors / Q000187:drug effects*; D013141:Spiro Compounds / Q000378:metabolism / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014649:Vas Deferens / Q000187:drug effects
D017465:Receptors, Opioid, delta; D013141:Spiro Compounds; C082822:7-spiroindanyloxymorphone; D010111:Oxymorphone