Ductal adenoma of the breast. An immunohistochemical study of five cases.
The immunohistochemical features of 5 ductal adenomas of the breast were investigated. The tumours were composed by tubular glands lined by cells with both luminal and basal/myoepithelial immunophenotypes. Tubules were encircled by an intact basement membrane as demonstrated by staining for laminin and type IV collagen. Areas of dense fibrosis, a usual finding in these lesions, stained for fibronectin, type III collagen and contained vimentin and actin positive spindle cells, consistent with myofibroblasts. These observations confirm a double epithelial and myoepithelial differentiation in these lesions and seem to support the suggestion that ductal adenomas result from sclerosis of ductal papillomas.
Department of Anatomical Pathology, Hospital of Treviglio, Italy.
M
M
Guarino
D
D
Reale
S
S
Squillaci
G
G
Micoli
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D003598:Cytoskeletal Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010212:Papilloma / Q000737:chemistry / Q000473:pathology*
D003598:Cytoskeletal Proteins