Calcium acetate versus calcium carbonate as phosphorus binders in patients on chronic haemodialysis: a controlled study.
The first reported double-blind cross-over comparison between the phosphorus binders calcium carbonate and calcium acetate was undertaken in 15 stable patients on chronic maintenance haemodialysis. Detailed registration of diet and analysis of the protein catabolic rate suggested an unchanged phosphorus intake during the study. It was found that predialytic serum phosphate concentration was significantly decreased by 0.11 mmol/l (0.34 mg/dl) (P = 0.021, 95% confidence limits 0.02-0.21 mmol/l; 0.06-0.65 mg/dl) during calcium acetate treatment. The calcium phosphate product was insignificantly decreased during treatment with calcium acetate whereas we could not exclude the possibility that calcium concentration had increased.
Ring
T
T
Department of Medicine C, Aalborg Hospital, Denmark.
Nielsen
C
C
Andersen
S P
SP
Behrens
J K
JK
Sodemann
B
B
Kornerup
H J
HJ
D000085:Acetates / Q000378:metabolism / Q000627:therapeutic use*; D019342:Acetic Acid; D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000097:blood; D002119:Calcium Carbonate / Q000378:metabolism / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000378:metabolism*; D016226:Phosphorus, Dietary / Q000494:pharmacology; D006435:Renal Dialysis; D013997:Time Factors
D000085:Acetates; D001639:Bicarbonates; D010281:Parathyroid Hormone; D016226:Phosphorus, Dietary; D010758:Phosphorus; D002119:Calcium Carbonate; D019342:Acetic Acid