Differential effect of subchronic dexamethasone treatment on serotonin-2 and beta-adrenergic receptors in the rat cerebral cortex and hippocampus.
The effect of the 10-day dexamethasone administration on serotonin-2 (5-HT2) and beta-adrenergic receptor binding sites was evaluated in rat cerebral cortex and hippocampus. The dexamethasone treatment (1, 2 and 5 mg/kg) significantly increased the density of the 5-HT2 receptor binding sites in a dose-dependent manner, whereas a decreased density of beta-adrenergic receptor binding sites was observed in rat cortex. In contrast, there were no significant differences in the densities of the 5-HT2 or beta-adrenergic receptor binding sites in rat hippocampus using dexamethasone. The results suggest that dexamethasone differentially modulates the 5-HT2 and beta-adrenergic receptor binding sites in rat brain.
Division of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan.
Y
Y
Kuroda
M
M
Mikuni
N
N
Nomura
K
K
Takahashi
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007650:Ketanserin / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009928:Organ Specificity; D011412:Propanolamines / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D011965:Receptors, Glucocorticoid / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects*; D015854:Up-Regulation / Q000187:drug effects
D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D011965:Receptors, Glucocorticoid; D011985:Receptors, Serotonin; C028697:dexamethasone receptor; D003907:Dexamethasone; D007650:Ketanserin; C033394:CGP 12177