[Structural and function of the human macrophage scavenger receptor].
Macrophage scavenger receptors (MSR) mediate the binding, internalization and processing of the wide range of negatively charged macromolecules. Functional receptors are trimers of two C-terminally different subunit containing 6 functional domains; cytoplasmic, transmembrane, spacer, alpha-helical coiled-coil, collagen-like, type specific domain. The C-terminal region of the collagen-like domain is essential for the ligand recognition of MSR. Human MSR gene consists of 11 exons, and two types of mRNAs are generated by alternative splicing from exon 8 to either exon 9 (type II) or to exons 10 and 11 (type I). Exon 1 encodes the 5' untranslated resion followed by a 12 kb intron which separates the transcription initiation site and the translation initiation site. Exon 2 encodes a cytoplasmic domain; Exon 3, a transmembrane domain; Exons 4 and 5, an alpha-helical coiled-coil; and exon 6 to 8, a collagen-like domain. The MSR gene consists of a mosaic of exons which encode the functional domains. The arrangement of exons helped determine the fine structural characteristics of functional domains.
Third Department of Internal Medicine, University of Tokyo.
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Asaoka
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Matsumoto
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Itakura
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Kodama
D001161:Arteriosclerosis / Q000209:etiology; D001483:Base Sequence; D005487:Foam Cells / Q000502:physiology; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A
D008077:Lipoproteins, LDL; C495139:MSR1 protein, human; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A