Psychoactive drug induced alteration of tryptamine tetrazolium reductase activity in rat brain.
The psychoactive drugs imipramine, chlorpromazine and lithium chloride inhibit tryptamine tetrazolium reductase activity in vitro by 68, 60 and 33% respectively at a concentration of 1 x 10(-3) M while amphetamine negligibly inhibits the enzyme activity. No change in enzyme activity is observed in vivo.
Indian Institute of Chemical Biology, Jadavpur, Calcutta.
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D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002712:Chlorides / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D008297:Male; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats
D002712:Chlorides; D011619:Psychotropic Drugs; D008094:Lithium; C019669:amine tetrazolium reductase; D000587:Oxidoreductases Acting on CH-NH Group Donors; D018021:Lithium Chloride; D007099:Imipramine; D003913:Dextroamphetamine; D002746:Chlorpromazine