[The effect of L-DOPA and 6-hydroxydopamine on the intracellular cAMP level in the kidneys of rats with impaired neurotrophic support of the organs].
The administration to rats surviving reflectory renal dystrophy of L-DOPA causing the disturbance in the function of mineralocorticoid receptors was demonstrated to be accompanied by an increase of cAMP concentration in the kidneys whereas 6-oxidopamine alleviating the damage of these receptors led to a reduction of cAMP content in the organ. It is assumed that catecholamine-activated adenylate-cyclase system and the processes initiated thereby which determine protein metabolism in renal tubule cells, among them protein subunits of mineralocorticoid receptors may take part in the mechanisms of functional disorders of mineralocorticoid receptors of the kidneys with impaired neurotrophic supply and in the mechanisms of normalization of this function.
Egorova
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LK
D000315:Adrenalectomy; D000818:Animals; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008901:Mineralocorticoids / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid / Q000187:drug effects / Q000378:metabolism; D012584:Sciatic Nerve / Q000502:physiology; D013997:Time Factors
D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid; D007980:Levodopa; D016627:Oxidopamine; D000242:Cyclic AMP