Effect of divergent selection for immune responsiveness and of major histocompatibility complex on resistance to Marek's disease in chickens.
Lines of chickens selected for nine generations for high (H) or low (L) antibody response to SRBC, a randombred control (C) line, and an F1 cross between H and L lines were challenged for resistance to Marek's disease (MD). Hens only were challenged at day-old by contact with virulent MD Strain K. Birds were serologically typed for MHC erythrocyte antigens. Chicks from the L and H lines died earlier and later, respectively, than the C chicks, whereas time of death did not differ between F1 birds and the L chicks. Mortality in the L line (70.1%) was higher than in the C line (42.8%), but mortality in the H line (40.9%) was not lower than in the C line or the F1 cross (47.5%). Effects of MHC genotypes and haplotypes on mortality from MD were estimated within lines with a logistic regression model. Effect of MHC was moderate in the H line (P < .10) and highly significant in the C line (P < .005). Effects of MHC genotypes were similar in the H and C line but differed in the L and F1. Heritability of mortality from MD estimated with a threshold model including relationships between individuals was .40 when all lines were grouped together, whereas heritability estimated for each line separately was .45, .51, and .78 in the H, C, and L lines, respectively. Correlations between estimated breeding values for antibody response to SRBC and mortality from MD varied between lines and sexes. Correlations also were affected by whether or not the MHC effect was taken into account.
Department of Animal Husbandry, Wageningen Agricultural University, The Netherlands.
M H
MH
Pinard
L L
LL
Janss
R
R
Maatman
J P
JP
Noordhuizen
A J
AJ
van der Zijpp
D000818:Animals; D000917:Antibody Formation; D002645:Chickens; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005838:Genotype; D006239:Haplotypes; D008381:Herpesvirus 2, Gallid / Q000276:immunology* / Q000472:pathogenicity; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D008297:Male; D008380:Marek Disease / Q000276:immunology* / Q000401:mortality; D011336:Probability; D012756:Sheep; D014774:Virulence