The thyroid hormone receptor interferes with transcriptional activation via the AP-1 complex.
The nuclear thyroid hormone (T3) receptor, encoded by the c-erbA genes, represses transcriptional activation by the transcription factor AP-1 in a T3-dependent fashion. The viral homologue of the T3 receptor, the v-erbA gene product, does not repress AP-1 activity. Inhibition by T3 involves reduced binding of AP-1 to its cognate DNA target sequence. The reduction in AP-1 binding does not, however, result from competitive binding by the T3 receptor to the AP-1 response element.
Department of Anatomy & Embryology, AMC, Amsterdam, The Netherlands.
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ED
Schmidt
S J
SJ
Cramer
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Offringa
D001483:Base Sequence; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D004247:DNA / Q000378:metabolism; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D014284:Triiodothyronine / Q000378:metabolism
D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D011988:Receptors, Thyroid Hormone; D014284:Triiodothyronine; D004247:DNA; D015500:Chloramphenicol O-Acetyltransferase