Ischemic colitis in a patient with Crohn's disease taking an oral contraceptive and an ergotamine alkaloid.
A 22-year-old woman developed transient left-sided ischemic colitis with submucosal oedema and bleeding, six weeks after an uneventful right hemicolectomy for Crohn's disease. The thrombogenic properties of the contraceptive pill and the concomitant use of an ergotamine alkaloid were thought to be the cause of this complication in a patient at risk. An increase of procoagulant activity and underlying vascular injury has been described in Crohn's disease.
Department of Gastroenterology, Heilig Hart Kliniek, Belgium.
L
L
Rutgeerts
G
G
Ghillebert
W
W
Drognee
W
W
Tanghe
P
P
Vuylsteke
M
M
Decoster
D000328:Adult; D003092:Colitis / Q000139:chemically induced*; D003106:Colon / Q000098:blood supply*; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects*; D003424:Crohn Disease / Q000150:complications*; D004087:Dihydroergotamine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply; D007511:Ischemia / Q000139:chemically induced*
D003280:Contraceptives, Oral, Synthetic; D004087:Dihydroergotamine