Varicella infection complicated with meningitis after immunization.
A healthy 45 month old boy who had received varicella vaccine 21 months previously developed aseptic meningitis along with an episode of varicella. The presence of viral DNA in cerebrospinal fluid (CSF) detected by polymerase chain reaction (PCR) with Southern blot hybridization confirmed the relationship between the symptoms and the CSF pleocytosis. This is the first reported case of this complication of varicella meningitis occurring in a child with documented immunization and seroconversion.
Department of Pediatrics, Showa Hospital, Kohnan, Japan.
H
H
Naruse
H
H
Miwata
T
T
Ozaki
Y
Y
Asano
J
J
Namazue
K
K
Yamanishi
D000914:Antibodies, Viral / Q000097:blood; D001345:Autoradiography; D015139:Blotting, Southern; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000382:microbiology; D002644:Chickenpox / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology*; D019433:Chickenpox Vaccine; D002675:Child, Preschool; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D008297:Male; D008587:Meningitis, Viral / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology*; D016133:Polymerase Chain Reaction; D014611:Vaccination / Q000009:adverse effects*; D014613:Vaccines, Attenuated / Q000009:adverse effects*; D014765:Viral Vaccines / Q000009:adverse effects*
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D004279:DNA, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines