Polyneuropathy complicating bone marrow and solid organ transplantation.
We report a generalized polyneuropathy coincident with the occurrence of graft-versus-host disease in four patients undergoing bone marrow transplantation and accompanying solid organ rejection (heart and kidney) in two patients. The neuropathy affected proximal and distal muscles, demonstrated hyporeflexia or areflexia, and usually had elevated CSF protein. Electrophysiologic studies did not meet strict criteria for demyelination. The signs of neuropathy improved after immunosuppressive treatment or simultaneous to the resolution of graft-versus-host disease or tissue rejection. Polyneuropathy must be considered as a potential complication of tissue transplantation.
Amato
A A
AA
Department of Neurology, Ohio State University School of Medicine, Columbus.
Barohn
R J
RJ
Sahenk
Z
Z
Tutschka
P J
PJ
Mendell
J R
JR
D000328:Adult; D016026:Bone Marrow Transplantation; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D004594:Electrophysiology; D006086:Graft vs Host Disease / Q000150:complications* / Q000378:metabolism; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology
D002556:Cerebrospinal Fluid Proteins