Histochemical and immunocytochemical study of ubiquitinated neuronal inclusions in amyotrophic lateral sclerosis.
Ubiquinated cytoplasmic inclusions are a characteristic feature of the anterior horn cell pathology of amyotrophic lateral sclerosis. The underlying abnormality leading to the production of these inclusions in this neurodegenerative motor system disease is unknown. Despite the application of a wide range of histochemical and immunocytochemical techniques we have been unable to identify a core constituent protein in these intraneuronal inclusions. A novel approach to this problem is required.
Department of Neuropathology, Royal London Hospital.
K
K
Mather
J E
JE
Martin
M
M
Swash
G
G
Vowles
A
A
Brown
P N
PN
Leigh
D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure*; D013116:Spinal Cord / Q000473:pathology; D014452:Ubiquitins / Q000276:immunology / Q000378:metabolism*
D014452:Ubiquitins