Nonfatal prolonged overdosage of pyrimethamine in an infant: measurement of plasma and urine levels using HPLC with diode-array detection.
A nonfatal case of accidental prolonged overdosage of pyrimethamine (10 times the usual dose for 10 days) in a seven-week-old infant treated for congenital toxoplasmosis is presented. The drug was identified and quantitated in plasma and urine using an HPLC technique with diode-array detection. Initial plasma concentration of pyrimethamine was 6.22 micrograms/mL. Results are discussed in light of the existing literature.
Institut de Médecine Légale, Faculte de Médecine, Strasbourg, France.
A
A
Tracqui
I
I
Mikail
P
P
Kintz
P
P
Mangin
D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007223:Infant; D011739:Pyrimethamine / Q000032:analysis* / Q000097:blood / Q000506:poisoning* / Q000652:urine; D013053:Spectrophotometry; D014125:Toxoplasmosis, Congenital / Q000188:drug therapy
D011739:Pyrimethamine