Prevalence of Helicobacter pylori in patients with chronic renal failure.
The prevalence of Helicobacter pylori (H. pylori) was investigated in 164 consecutive patients with different degrees of renal function; group I (normal renal function) n = 84, group II (chronic renal failure, CLCR > or = 5 < 90 ml/min) n = 45, group III (haemodialysis therapy) n = 35, to test the hypothesis that the resulting different concentrations of urea in the gastric juice would have an influence on the colonization of the gastric mucosa by these urea-splitting bacteria. As every individual method for the detection of H. pylori shows disadvantages, the results of the detection methods used (urease test, Warthin-Starry stain, bacterial cultivation, direct examination of the processed sample by phase-contrast microscopy) were combined in a cumulative evaluation. These calculated cumulative indices for the antrum and corpus showed no statistically significant differences between the studied groups. The prevalence of H. pylori ranged from 34 to 54%. The histopathological findings were similar in all groups. In spite of the fact that patients with renal dysfunction had significantly higher levels of serum gastrin (P < 0.05), there was no influence on the gastric juice pH value. The relationship between the cumulative index and ammonia concentration in gastric juice was found to be linear (P < 0.05). The higher urea levels in the blood and gastric juice of patients with renal failure do not seem to be a risk factor for infection with H. pylori.
Department of Internal Medicine II, Technical University of Aachen, Germany.
U
U
Gladziwa
G
G
Haase
S
S
Handt
J
J
Riehl
H
H
Wietholtz
K V
KV
Dakshinamurty
W M
WM
Glöckner
H G
HG
Sieberth
D000641:Ammonia / Q000032:analysis; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000382:microbiology; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007676:Kidney Failure, Chronic / Q000382:microbiology* / Q000473:pathology; D010437:Peptic Ulcer / Q000382:microbiology; D013276:Stomach Ulcer / Q000382:microbiology
D005755:Gastrins; D000641:Ammonia