Effect of lithium salts on the microstructure of the thymus and on vitamin C content in some lymphatic organs, the liver and suprarenal glands in F1 mouse crosses (CBA x C57BL).
The administration of lithium chloride (LiCl) to mice by intraperitoneal injection caused involution in the thymus, both in the cortex and medulla. Lithium also considerably decreased vitamin C (ascorbic acid) content in all of the organs that were studied: thymus, lymph nodes, spleen, suprarenal glands, and liver.
Department of Animal Physiology, Jagiellonian University, Cracow, Poland.
W
W
Ficek
J
J
Lesniewska
D
D
Mrowca
D000311:Adrenal Glands / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects*; D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis*; D002712:Chlorides / Q000008:administration & dosage*; D003433:Crosses, Genetic; D005260:Female; D007274:Injections, Intraperitoneal; D008094:Lithium / Q000008:administration & dosage*; D018021:Lithium Chloride; D008099:Liver / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects*; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects*
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride; D001205:Ascorbic Acid