Elevation of human cerebrospinal fluid clusterin concentration is associated with acute neuropathology.
Clusterin is a serum glycoprotein which is an inhibitor of complement and is expressed in many tissues in cell injury and death. It has been identified normal and pathological brain tissue and is a component of normal human cerebrospinal fluid (CSF). We have measured the clusterin concentration of 115 abnormal and normal human CSF samples and related these data to the patient's clinical diagnoses. CSF clusterin levels in patients with neurodegenerative and meningeal disease were within the normal range. Twelve of 15 patients with demyelination, however, had significant elevation of CSF clusterin concentration. This was not a specific finding for multiple sclerosis as elevated clusterin levels were also seen in patients with other acute neuropathology. Determination of CSF clusterin concentration may be of clinical value in neurological diagnosis.
Department of Nephrology, St. Vincent's Hospital, Melbourne, Australia.
M
M
Polihronis
K
K
Paizis
G
G
Carter
L
L
Sedal
B
B
Murphy
D000208:Acute Disease; D000775:Anesthesia, Spinal; D015153:Blotting, Western; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D051152:Clusterin; D003186:Complement C9 / Q000134:cerebrospinal fluid; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid; D006023:Glycoproteins / Q000134:cerebrospinal fluid*; D006801:Humans; D018832:Molecular Chaperones; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D009994:Osmolar Concentration; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid; D012016:Reference Values
C495242:CLU protein, human; D002556:Cerebrospinal Fluid Proteins; D051152:Clusterin; D003186:Complement C9; D006023:Glycoproteins; D018832:Molecular Chaperones