Azithromycin for treatment of severe Cryptosporidium diarrhea in two children with cancer.
Two children with cancer received azithromycin for Cryptosporidium-associated diarrhea that was unresponsive to supportive care. One child had choleriform diarrhea requiring daily fluid replacement of up to 65% of his total body weight; the other had protracted diarrhea and wasting. In both cases, administration of azithromycin was followed by prompt clinical improvement.
Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, TN 38105-2794.
S L
SL
Vargas
J L
JL
Shenep
P M
PM
Flynn
C H
CH
Pui
V M
VM
Santana
W T
WT
Hughes
D000284:Administration, Oral; D017963:Azithromycin; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000209:etiology; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D003968:Diarrhea, Infantile / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005440:Fluid Therapy; D006801:Humans; D007223:Infant; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications*; D009447:Neuroblastoma / Q000150:complications*; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000209:etiology; D012509:Sarcoma / Q000150:complications*
D004917:Erythromycin; D017963:Azithromycin