Biological characteristics of a novel immunosuppressant, IR-1116, specific for B lymphocytes.
Matsumoto
S
S
Takeda Chemical Industries, Discovery Research Division, Osaka, Japan.
Marui
S
S
Shiho
O
O
Tsukamoto
K
K
Yoshimura
N
N
Oka
T
T
D000328:Adult; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation / Q000276:immunology*; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012717:Sesquiterpenes / Q000494:pharmacology*; D013997:Time Factors; D014184:Transplantation, Homologous
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; C079842:IR 1116; D016572:Cyclosporine