Effect of saiboku-to (TJ-96) on bronchial asthma. Induction of glucocorticoid receptor, beta-adrenaline receptor, IgE-Fc epsilon receptor expression and its effect on experimental immediate and late asthmatic reaction.
A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 agonists and suppressed mACh receptor at the same time. Saiboku-to increased tyrosine aminotransferase (TAT) production, which was inhibited by actinomycin-D, thus having steroid-like activity. In mite-allergic asthma, Saiboku-to inhibited the induction of expression of IgE-Fc epsilon R/CD23 in the lymphocytes by mite allergen. It also inhibited IgE production by mite allergens. In experimental asthma in guinea pigs the use of Saiboku-to resulted in a decrease in the number of eosinophils in the bronchoalveolar lavage fluid during late asthmatic response. These findings suggest that Saiboku-to may be effective in inhibiting both the expression of IgE-Fc epsilon R2 and the induction of expression of IgE-Fc epsilon R1. Saiboku-to also has a steroid-like action and polyhedral anti-asthmatic activities.
Nakajima
S
S
Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
Tohda
Y
Y
Ohkawa
K
K
Chihara
J
J
Nagasaka
Y
Y
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D020835:Medicine, Kampo; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000187:drug effects*; D011965:Receptors, Glucocorticoid / Q000032:analysis / Q000187:drug effects*; D017455:Receptors, IgE / Q000032:analysis / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D011943:Receptors, Adrenergic, beta; D011965:Receptors, Glucocorticoid; D017455:Receptors, IgE; C045086:saiboku-to; D007073:Immunoglobulin E