Extinction of gene expression in somatic cell hybrids--a reflection of important regulatory mechanisms?
Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell differentiation.
Genecenter, Max Planck Institute for Biochemistry, Martinsried, Germany.
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Boshart
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Nitsch
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Schütz
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; D017868:Cyclic AMP-Dependent Protein Kinases; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology*; D051379:Mice; D011494:Protein Kinases / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000502:physiology
D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; C517834:PRKAR1A protein, human; C517835:Prkar1a protein, mouse; D011506:Proteins; D011494:Protein Kinases; D017868:Cyclic AMP-Dependent Protein Kinases