Effects of choline-esterase inhibitor in experimental acute pancreatitis in rats. Preliminary results.
Choline-esterase inhibitor (C1-INH), a regulatory alpha-glycoprotein, was administered at different dosages and intervals to rats with induced acute pancreatitis. When compared to controls, treated rats showed no significant differences in the severity of histopathological lesions, such as edema and single cell necrosis. On the other hand, both mortality and extent of massive necrosis were significantly affected by C1-INH administration regardless of the dosages.
Vesentini
S
S
Surgical Department, University of Verona, Italy.
Benetti
L
L
Bassi
C
C
Bonora
A
A
Campedelli
A
A
Zamboni
G
G
Castelli
P
P
Pederzoli
P
P
D000208:Acute Disease; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use*; D008297:Male; D010195:Pancreatitis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D002800:Cholinesterase Inhibitors; D003174:Complement C1 Inactivator Proteins