Interaction of Mycoplasma arthritidis superantigen with human T cells.
To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the V beta 17 gene segment; however, other V beta may also be used and not all V beta 17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive V beta sequences suggests that MAM does not interact with a single site encoded by a V beta segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site.
Department of Medicine, Cornell University Medical College, New York, New York 10021.
D N
DN
Posnett
A S
AS
Hodtsev
S
S
Kabak
S M
SM
Friedman
B C
BC
Cole
N
N
Bhardwaj
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens; D000942:Antigens, Bacterial; D001665:Binding Sites / Q000235:genetics; D002460:Cell Line; D017124:Conserved Sequence; D006801:Humans; D051379:Mice; D008934:Mitogens / Q000276:immunology*; D008969:Molecular Sequence Data; D009174:Mycoplasma / Q000276:immunology*; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment; D018089:Superantigens; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000942:Antigens, Bacterial; D008934:Mitogens; C052996:Mycoplasma arthritidis mitogen; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens