The combined immunological and antinociceptive defects of beige-J mice: the possible existence of a 'mu-repressin'.
A selective non-responsiveness to the analgesic effects of opioid mu receptor-, but not opioid delta receptor-, mediated antinociception in the tail-flick test has been identified in C57BL/6J-bgJ (beige-J) mice. The beige-J mutation is also known to give rise to multiple immunological disorders and immune cell dysfunctions. A link between these apparently disparate manifestations has been examined in a series of studies using, for example, adoptive transfer of spleen cells. The findings appear to have broad implications for the link between the immune and opioid systems.
Drug Discovery Research, R.W. Johnson Pharmaceutical Research Institute, PA 19477-0776.
R B
RB
Raffa
J R
JR
Mathiasen
E S
ES
Kimball
J L
JL
Vaught
D000818:Animals; D007109:Immunity / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology* / Q000502:physiology*; D010146:Pain / Q000235:genetics* / Q000503:physiopathology; D017465:Receptors, Opioid, delta / Q000235:genetics; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000235:genetics*
D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu