The use of monoclonal antibodies to achieve immunological tolerance.
Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.
Immunology Division, Dept of Pathology, Cambridge, UK.
H
H
Waldmann
S
S
Cobbold
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000628:therapy; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008285:Major Histocompatibility Complex; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents