Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia.
Kest
B
B
Department of Psychology, University of California, Los Angeles 90024.
Mogil
J S
JS
Sternberg
W F
WF
Liebeskind
J C
JC
Sadowski
B
B
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000698:Analgesia; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D005260:Female; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D017473:Receptors, Opioid, kappa / Q000187:drug effects / Q000235:genetics*; D013315:Stress, Psychological / Q000523:psychology; D013550:Swimming; D015854:Up-Regulation / Q000235:genetics*
D000700:Analgesics; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; C051844:norbinaltorphimine; D009271:Naltrexone; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D009020:Morphine