Tetrodotoxin enhances light-induced c-fos gene expression in the rabbit retina.
Action potentials within the rabbit retina were blocked by the intravitreal injection of tetrodotoxin (TTX), and c-fos expression was studied after exposure to flashing light. Light induced Fos proteins in a minority of neurons in the inner nuclear and ganglion cell layers of control retinas. Pretreatment with TTX increased the number of Fos-positive cells and the levels of c-fos mRNA. Wide-field amacrine cells, which presumably generate action potentials, may have an inhibitory role in light-stimulated rabbit retina.
Department of Neurology, University of California, San Francisco.
J
J
Koistinaho
K J
KJ
Hicks
S M
SM
Sagar
D000818:Animals; D015152:Blotting, Northern; D004298:Dopamine / Q000502:physiology; D005136:Eye Proteins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000528:radiation effects; D016762:Genes, fos; D008297:Male; D010775:Photic Stimulation; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D011817:Rabbits; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013268:Stimulation, Chemical; D013779:Tetrodotoxin / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005136:Eye Proteins; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine