[Clinical significance of tumor cell DNA analysis in patients with large hepatocellular carcinoma treated with irradiation combined with traditional Chinese medicine].
There has not been reported that DNA ploidy status of hepatocellular carcinoma may be used to predict the prognosis of patients with large liver cancer treated with radiotherapy combined with Chinese traditional medicine. In this series, the ploidy of DNA pattern in 28 cases were analyzed. Of them, the diploid accounts for 57.14% and aneuploid for 42.86%. Correlative analysis indicated that the clinical course of the disease in diploid cases was less severe than those in aneuploid ones (P < 0.05) and the response to treatment of patients with diploid DNA pattern was better than that of aneuploid ones (P < 0.01). However, there was no significant correlation between ploidy of DNA pattern and tumor size, AFP level or degree of differentiation of cancer cells (P > 0.05), which indicated that the ploidy pattern may be of significance in the treatment outcome of large liver cancer by radiotherapy.
Liu
L M
LM
Cancer Hospital/Cancer Institute, Shanghai Medical University.
D000328:Adult; D000782:Aneuploidy; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000628:therapy*; D003037:Cobalt Radioisotopes; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000235:genetics*; D004171:Diploidy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011867:Radioisotope Teletherapy; D011882:Radiotherapy, High-Energy
D003037:Cobalt Radioisotopes; D004273:DNA, Neoplasm; D004365:Drugs, Chinese Herbal