[TNF and TNF receptors: structure, mechanism of action, role in disease and therapy].
In this article, the topics on TNF and TNF receptors presented in the 4th International Conference on Tumor Necrosis Factor and Related Cytokines (Netherlands, May, 1992) are briefly summarized in Japanese, based on Dr. Benjamin Bonavida's report (Cancer Update, supplement 8, 1992) with permission. Following categorized themes were discussed in the meeting: 1) regulation of TNF synthesis, especially at the transcriptional level, 2) TNF receptors, including type I (55 kd), type II (75 kd) and soluble forms, 3) TNF cytotoxicity and immunomodulation with considerations for mechanisms, 4) TNF and infectious diseases such as Plasmodium falciparum infection, 5) TNF and inflammatory diseases such as rheumatoid arthritis and 6) TNF and cancer, in attempts to overcome drug resistance and TNF toxicity.
Mayo Clinic, University of California, Los Angeles.
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Morimoto
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Bonavida
D001172:Arthritis, Rheumatoid / Q000628:therapy; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D016778:Malaria, Falciparum / Q000628:therapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry / Q000502:physiology / Q000627:therapeutic use
D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha