Differanisole A, an inducer of the differentiation of Friend leukemic cells, induces stalk cell differentiation in Dictyostelium discoideum.
Differanisole A isolated from the conditioned medium of a soil microorganism, Chaetomium strain RB-001, is an inducer of the differentiation of the Friend leukemic cells (mouse leukemia cells). The chemical structure of this substance is very similar to that of stalk cell differentiation-inducing factor (DIF) isolated from the cellular slime mould, Dictyostelium discoideum. We examined the effects of differanisole A on Dictyostelium HM44 cells, a mutant strain which is defective in DIF production, and found this substance to be an inducer of stalk cell differentiation in D. discoideum.
Kubohara
Y
Y
Department of Botany, Faculty of Science, Kyoto University, Japan.
Okamoto
K
K
Tanaka
Y
Y
Asahi
K
K
Sakurai
A
A
Takahashi
N
N
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002723:Chlorobenzoates / Q000737:chemistry / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D004023:Dictyostelium / Q000166:cytology / Q000187:drug effects*; D006588:Hexanones / Q000737:chemistry / Q000494:pharmacology; D004915:Leukemia, Erythroblastic, Acute; D051379:Mice; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D002723:Chlorobenzoates; D006588:Hexanones; C053433:1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; C046689:differanisole A; D000242:Cyclic AMP