Skeletal myogenesis: genetics and embryology to the fore.
The MyoD family of transcription factors are expressed in the skeletal muscles of vertebrate and invertebrate embryos and have dominant regulatory activities that indicate their important developmental functions in myogenic lineage determination and muscle differentiation. Genetic studies, however, reveal that individually, myoD-related genes are not essential for myogenic lineage determination in mouse and Caenorhabditis elegans embryos, but have differentiation functions and perhaps redundant functions in lineage determination that remain to be defined by further genetic studies.
Emerson
C P
CP
Institute for Cancer Research, Fox Chase Cancer Center, PA 19111.
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins; D005314:Embryonic and Fetal Development / Q000235:genetics; D006801:Humans; D007448:Invertebrates / Q000196:embryology / Q000235:genetics; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000235:genetics; D005810:Multigene Family; D009124:Muscle Proteins / Q000235:genetics* / Q000502:physiology; D009132:Muscles / Q000196:embryology*; D017570:MyoD Protein; D051787:Myogenic Regulatory Factor 5; D018006:Myogenic Regulatory Factors; D018008:Myogenin; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology; D010750:Phosphoproteins / Q000235:genetics* / Q000502:physiology; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D014714:Vertebrates / Q000196:embryology / Q000235:genetics
D004268:DNA-Binding Proteins; C497417:MYF5 protein, human; C503799:MYOG protein, human; D009124:Muscle Proteins; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D051787:Myogenic Regulatory Factor 5; D018006:Myogenic Regulatory Factors; D018008:Myogenin; D009687:Nuclear Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D014157:Transcription Factors; C063403:myogenic factor 6