[Selective blood sampling from the sinus petrosus inferior: a comparison of CRF and TRH stimulation].
In 10 patients with hypophyseal Cushing microadenomas, selective bilateral sampling from the inferior petrosal sinuses was performed and the effect of stimulation by iv TRH and CRF was compared. On the side of the microadenoma. ACTH concentration rose from 650 +/- 242 pg/ml to 2712 +/- 843 pg/ml following injection of CRF and 2025 +/- 242 pg/ml after TRH. Contralateral values were 165 +/- 79 pg/ml, 490 +/- 200 pg/ml and 165 +/- 72 pg/ml respectively. Prolactin concentration on the side of the adenoma was 98 +/- 49 ng/ml before stimulation, 236 +/- 62 ng/ml after CRF and 747 +/- 168 ng/ml after TRH. Contralateral concentration was 22 +/- 10 ng/ml, 64 +/- 19 ng/ml respectively. Sampling localised all adenomas correctly, whereas contrast-enhanced MRT diagnosed only four adenomas.
Klinik für Radiologie, Abteilung für innere Medizin--Endokrinologie, Johannes-Gutenberg-Universität, Mainz.
H
H
Schild
T
T
Strack
H
H
Strunk
P
P
Mildenberger
J
J
Schrezenmeir
G
G
Kahaly
J
J
Beyer
D000236:Adenoma / Q000097:blood* / Q000175:diagnosis; D000324:Adrenocorticotropic Hormone / Q000097:blood; D003287:Contrast Media; D003346:Corticotropin-Releasing Hormone; D003392:Cranial Sinuses / Q000473:pathology*; D003480:Cushing Syndrome / Q000097:blood* / Q000175:diagnosis; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D004369:Pentetic Acid; D010865:Pilot Projects; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000097:blood* / Q000175:diagnosis; D011388:Prolactin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013997:Time Factors
D003287:Contrast Media; D009942:Organometallic Compounds; D013973:Thyrotropin-Releasing Hormone; D004369:Pentetic Acid; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D003346:Corticotropin-Releasing Hormone; D005682:Gadolinium; D019786:Gadolinium DTPA