Chronic barbiturate treatment increases NMDA receptors but decreases kainate receptors in mouse cortex.
Chronic phenobarbital effects on brain NMDA and kainate receptors were assessed using [3H]MK-801 and [3H]kainate. Mice fed a phenobarbital diet for 7 days had a higher density of MK-801 binding sites (NMDA receptors) but a lower density of kainate receptors in cortex than control mice. No changes in MK-801 or kainate binding were observed in hippocampus. The results suggest brain area specific adaptation of certain glutamate receptors to chronic barbiturate treatment.
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Department of Pharmacology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Tabakoff
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B
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000378:metabolism / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010634:Phenobarbital / Q000494:pharmacology*; D017470:Receptors, Glutamate / Q000187:drug effects*; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*
D016291:Dizocilpine Maleate; D010634:Phenobarbital; D017470:Receptors, Glutamate; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate