Divergent differentiation in small round-cell tumours of the soft tissues with neural features--an analysis of 10 cases.
A series of 10 small round-cell tumours, having in common evidence of neural differentiation, were investigated by immunohistochemistry and electronmicroscopy. In seven, evidence of divergent muscle and/or epithelial differentiation was found. This phenomenon thus appears more common than previously appreciated and suggests that there may be a continuous and overlapping phenotypic spectrum from Ewing's tumour of soft tissue to intra-abdominal desmoplastic small cell tumour.
Department of Histopathology, Christie Hospital, Manchester, UK.
J M
JM
Pearson
M
M
Harris
B P
BP
Eyden
S S
SS
Banerjee
D000293:Adolescent; D000328:Adult; D002454:Cell Differentiation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000473:pathology; D012512:Sarcoma, Ewing / Q000235:genetics / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013899:Thoracic Neoplasms / Q000473:pathology