Changes in serum immunoreactive inhibin-alpha during photoperiod-induced testicular regression and recrudescence in the golden hamster.
Serum immunoreactive inhibin-alpha (irI alpha), FSH, LH, and testosterone (T) were measured in male golden hamsters during short-day-induced testicular regression and during testicular recrudescence following the transfer from short to long days. Serum FSH levels were maximally suppressed within 2 wk of transfer to short days. In contrast to FSH, irI alpha levels were not fully reduced until after 6 wk of exposure to short days, closely paralleling the timing of testicular regression. LH and T levels were also reduced within two 2k, with maximal suppression observed between 6 and 8 wk. Conversely, when males with regressed testes were transferred to long days, serum FSH rose to peak (25 ng/ml) levels by 3 wk and then declined to usual long-day levels. In contrast, serum irI alpha levels rose gradually, reaching adult long-day levels following 10 wk of exposure. Serum LH and T levels rose to peak levels between 5 and 8 wk before declining to adult levels. FSH, LH, and irI alpha levels were also measured after castration in male hamsters maintained on long or short days. Twenty-four hours after castration, levels of irI alpha were reduced in long-day males to levels comparable to those observed in castrated short-day males. Serum irI alpha levels respond slowly to abrupt changes in FSH levels after transfer to either long or short days, suggesting that testicular irI alpha secretion may not be directly and immediately influenced by circulating FSH levels in the hamster.(ABSTRACT TRUNCATED AT 250 WORDS)
Kirby
J D
JD
Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208.
Jetton
A E
AE
Ackland
J F
JF
Turek
F W
FW
Schwartz
N B
NB
D000818:Animals; D006224:Cricetinae; D005640:Follicle Stimulating Hormone / Q000097:blood; D007265:Inhibins / Q000097:blood*; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008647:Mesocricetus; D009919:Orchiectomy; D017440:Photoperiod; D013737:Testis / Q000033:anatomy & histology / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone