Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A.
Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of delaminomycin A was determined to be 3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]- 1,6,8- trimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthyl]carbonyl]-5- hydroxypyrrolidine-2,4-dione by analyses of spectral properties and chemical studies.
Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
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Ueno
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Someno
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Sawa
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Iinuma
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Naganawa
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Ishizuka
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Takeuchi
D000276:Adjuvants, Immunologic / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D011760:Pyrrolidinones / Q000737:chemistry* / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D013302:Streptomyces / Q000737:chemistry*; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D011760:Pyrrolidinones; D011956:Receptors, Cell Surface; D013764:Tetrahydronaphthalenes; C052131:extracellular matrix receptor; C082438:delaminomycin A