Intraoperative chemohyperthermia in the management of digestive cancers. A general review of literature.
Intraoperative chemohyperthermia is a new method in the treatment of peritoneal seedings from digestive cancers, which combines surgery, intraperitoneal chemotherapy (mitomycin C and/or cisplatyl) and peritoneal hyperthermia. After a brief reminder on the general principles concerning high temperature action, a review of literature is made: 5 teams have performed this technique. We differentiate the indications, design features and results of each team. The results show a mean survival after 2 years of 35% (in peritoneal carcinomatosis) up to 78% (in gastric serosal invasion, peritoneal seeding free). The best result of the method is the drying up of cancerous ascites, allowing a more comfortable survival.
Department of Anesthesia, Centre Hospitalier, Lyon-Sud, Pierre-Bénite, France.
A C
AC
Sayag
F N
FN
Gilly
P Y
PY
Carry
J P
JP
Perdrix
G
G
Panteix
A
A
Brachet
V
V
Banssillon
G
G
Braillon
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004067:Digestive System Neoplasms / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D007432:Intraoperative Period; D008937:Mitomycins / Q000008:administration & dosage; D013696:Temperature; D013997:Time Factors
D008937:Mitomycins; D002945:Cisplatin