Immunocytochemical diagnosis of small cell undifferentiated carcinoma of the cervix.
Ethanol-fixed and Papanicolaou-stained smears of 5 cases of cervical small cell undifferentiated carcinoma and 10 control cases of non-small cell cervical cancer were immunocytochemically examined with monoclonal antibodies (MAbs) against cluster 1 small cell lung cancer (SCLC) antigen, which were found to react with neural cell adhesion molecules (N-CAM). MAbs against cluster 1 SCLC antigen used in this study were NCC-LU-243, NCC-LU-246 and anti-Leu-19. The expression of cluster 1 SCLC antigen was recognized by MAb NCC-LU-243 and NCC-LU-246 in all five cases and by anti-Leu-19 MAb in three. The cluster 1 SCLC antigen was not detected in any of the 10 non-small cell cervical cancers. These results suggest that cluster 1 SCLC antigen is stable and immunocytochemically detectable in Papanicolaou-stained smears and is helpful in the cytologic diagnosis of cervical small cell undifferentiated carcinoma.
Kamiya
M
M
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
Uei
Y
Y
Higo
Y
Y
Watanabe
Y
Y
Yamagishi
K
K
Shimosato
Y
Y
D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D015816:Cell Adhesion Molecules, Neuronal / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor; D015816:Cell Adhesion Molecules, Neuronal