[Studies on structures of urinary metabolites of quinotolast, a new oral anti-allergics].
Metabolites of quinotolast in the human, rat and dog urine were isolated chromatographically and their structures were determined spectroscopically. para-Hydroxy substitution to the phenoxyl function of quinotolast, and glucoside or glucuronide conjugate to its tetrazole ring were observed.
Kihara
N
N
Analytical Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
Sato
A
A
Kitamura
S
S
Okamoto
Y
Y
Yasuda
T
T
D000818:Animals; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005960:Glucosides / Q000652:urine*; D006801:Humans; D008297:Male; D011807:Quinolizines / Q000493:pharmacokinetics*; D051381:Rats; D013777:Tetrazoles / Q000493:pharmacokinetics*
D005960:Glucosides; D011807:Quinolizines; D013777:Tetrazoles; C074666:quinotolast