A comparison of the efficacy of danofloxacin and tylosin in the control of Mycoplasma gallisepticum infection in broiler chicks.
Groups of chicks were infected with a virulent strain of Mycoplasma gallisepticum (MG) and treated with either danofloxacin or tylosin while one infected group was left untreated and a further group was uninfected and untreated. Control of clinical signs and mortality was better with danofloxacin than tylosin and there was significantly (P < 0.05) greater weight gain with danofloxacin at 21 days after infection. However at necropsy the prevalence of lesions of the airsac walls was similar in both groups. MG was recovered from fewer live chicks for the first week following treatment with danofloxacin, but at 2 weeks and at necropsy, at the termination of the experiment, it was recovered from a similar proportion of birds in both treated groups. This was reflected also in the serological results at the end of the trial.
Jordan
F T
FT
Department of Veterinary Pathology, University of Liverpool Veterinary Field Station, Cheshire, UK.
Horrocks
B K
BK
Jones
S K
SK
Cooper
A C
AC
Giles
C J
CJ
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002645:Chickens; D024841:Fluoroquinolones; D008297:Male; D009175:Mycoplasma Infections / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D015363:Quinolones / Q000627:therapeutic use*; D015645:Tylosin / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C068581:danofloxacin; D015645:Tylosin