A familial/genetic study of plasma serine and glycine concentrations.
Plasma serine and glycine concentrations were assayed in a sample of 28 nuclear families (n = 108). Complex segregation analysis of these familial data reveals significant genetic control of concentrations via a single major gene locus. The serine and glycine metabolizing enzyme serine hydroxymethyltransferase (SHMT) is suggested as the most likely candidate for this single major gene locus.
Devor
E J
EJ
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
Waziri
R
R
D004298:Dopamine / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005998:Glycine / Q000097:blood* / Q000235:genetics; D006801:Humans; D007389:Internal-External Control; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D011618:Psychotic Disorders / Q000097:blood / Q000235:genetics*; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics; D012694:Serine / Q000097:blood*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D012694:Serine; D005680:gamma-Aminobutyric Acid; D005947:Glucose; D005998:Glycine; D004298:Dopamine