Trisomy 8 as a recurrent clonal abnormality in breast cancer?
The results of cytogenetic investigations on one benign and 15 malignant breast tumors are described. Trisomy 7, 8, 18, and 21 and monosomy X occurred as clonal numerical aberrations, and inv(7)(q21q31) and t(4;12)(q21;p13) occurred as clonal structural aberrations. Only trisomy 8 was a recurrent karyotypic abnormality, however. Thus, we assumed that trisomy 8 as an early genetic change characterizes a subtype of ductal breast carcinomas.
Center of Human Genetics and Genetic Counseling, University of Bremen, Germany.
J
J
Bullerdiek
E
E
Leuschner
E
E
Taquia
U
U
Bonk
S
S
Bartnitzke
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics*; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D014314:Trisomy; D014407:Tumor Cells, Cultured