Effects of CA antagonists on ethanol-induced excitation in habituated and nonhabituated mice: interaction with stress factors?
The effects of CA antagonists on ethanol induced locomotion in habituated (N) and nonhabituated (NH) mice was examined. H-mice were exposed to the testing apparatus for 4 days before testing. Mice were pretreated with pimozide (D2 antagonist), Schering 23390 (D1 antagonist), phenoxybenzamine (alpha 1 antagonist), or yohimbine (alpha 2 antagonist). Mice were then treated with ethanol. H mice had lower activity scores compared to NH mice. Ethanol produced an increase in activity for both groups. In NH animals, pimozide attenuated excitation in inverse relation to the ethanol dosage. In H mice, pimozide attenuated excitation only at doses that in themselves produced a decrease in activity. Schering 23390 reduced excitation only at doses that affected activity per se in both groups. Phenoxybenzamine reduced excitation dose-dependently in both groups. Yohimbine decreased excitation in both groups. Results suggest that stress emanating from a novel environment may affect not only activity per se but also the interaction between CA antagonists and ethanol.
Koechling
U M
UM
Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
Amit
Z
Z
D018674:Adrenergic Antagonists; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D002395:Catecholamines / Q000037:antagonists & inhibitors*; D065127:Dopamine D2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D004777:Environment; D000431:Ethanol / Q000494:pharmacology*; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010643:Phenoxybenzamine / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D013315:Stress, Psychological / Q000523:psychology*; D015016:Yohimbine / Q000494:pharmacology
D018674:Adrenergic Antagonists; D001552:Benzazepines; D002395:Catecholamines; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D010643:Phenoxybenzamine; D010868:Pimozide; D015016:Yohimbine; D000431:Ethanol