Menstrual-associated sleep disorder: an unusual hypersomniac variant associated with both menstruation and amenorrhea with a possible link to prolactin and metoclopramide.
A 42-year-old female presented with a history of hypersomnia associated with her menstrual periods. The menstrual periods abated coincident with the use of metoclopramide. The hypersomnolence, however, did not abate, but rather became more brief and erratic in its periodicity. The hypersomnolence was associated with marked elevations in the serum prolactin level.
Department of Neurology, University of Arizona, Tucson.
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Bamford
D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced / Q000188:drug therapy; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects / Q000378:metabolism*; D008774:Methylphenidate / Q000008:administration & dosage / Q000627:therapeutic use; D008787:Metoclopramide / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D017286:Polysomnography; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012895:Sleep, REM
D008774:Methylphenidate; D011388:Prolactin; D008787:Metoclopramide