White clot syndrome associated with renal failure.
In a minority of patients, heparin administration is associated with thrombocytopenia and this thrombocytopenia may be associated with thromboembolic events. Heparin-associated thromboembolism is described as heparin-associated thrombocytopenia and thrombosis or white clot syndrome. White clot syndrome is caused by antibodies to a heparin-platelet membrane complex. The diagnosis carries a high mortality and morbidity from limb thromboembolism. Treatment includes discontinuation of heparin, use of alternate anticoagulants, and aggressive treatment of thromboses. A case in which acute renal failure occurred in the setting of heparin treatment and thrombocytopenia is described, and evidence that renal failure was a result of white clot syndrome is provided.
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City 52242.
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Somers
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Sotolongo
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Bertolatus
D058186:Acute Kidney Injury / Q000209:etiology*; D016824:Antigens, Human Platelet / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000601:surgery; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000601:surgery; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D011183:Postoperative Complications / Q000188:drug therapy; D011485:Protein Binding; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy; D012082:Renal Veins; D018805:Sepsis / Q000150:complications; D013577:Syndrome; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications* / Q000276:immunology; D013927:Thrombosis / Q000139:chemically induced / Q000150:complications* / Q000276:immunology
D016824:Antigens, Human Platelet; D010980:Platelet Membrane Glycoproteins; D006493:Heparin