Effect of aspirin on mitochondrial lipids in experimental myocardial infarction in rats.
The effect of aspirin (0.45 mg/100 g body wt, orally for 60 days) on mitochondrial lipids induced by isoproterenol (200 mg/Kg body wt, Sc for 2 days) was studied in rats. In isoproterenol treated rats, marked increases in cholesterol, free fatty acids, triglycerides and lipid peroxides in heart mitochondria were observed. The phospholipid level was lowered with a significant increase in the activity of phospholipase. The activity of Na+K(+)-ATPase registered a decrease and the activity of Ca(2+)-ATPase increased in isoproterenol treatment. Aspirin treatment is found to counteract the effect of isoproterenol on lipid and lipid peroxide formation and associated enzyme changes in heart mitochondria.
Department of Biochemistry, University of Madras, India.
T S
TS
Manjula
C S
CS
Devi
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D007545:Isoproterenol / Q000633:toxicity; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D009203:Myocardial Infarction / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol; D001241:Aspirin