[The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency].
Experiments in rats with different sensitivity to hypobaric hypoxia established bimodal distribution of antipyrine and isoniazide half-lives. Moreover, the low-sensitive rats were rapid acetylators and slow oxidizers, but the high-sensitive ones vice versa. The slowing down of antipyrine and isoniazide metabolism is supposed to be the most rational reaction of oxygen-dependent systems to the lack of oxygen in tissues.
Sharapov
V I
VI
Kolpakov
M A
MA
Grek
O R
OR
D000208:Acute Disease; D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D001273:Atmosphere Exposure Chambers; D004198:Disease Susceptibility; D006207:Half-Life; D000860:Hypoxia / Q000097:blood*; D007538:Isoniazid / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000983:Antipyrine; D007538:Isoniazid