Challenges in the therapy of HIV infection.
Drugs that inhibit HIV replication have been shown to have clinical utility in patients with HIV infection. However, the immunological improvement induced by available anti-HIV therapies in patients with AIDS is incomplete and transient. Explanations for this may include immunological barriers to complete reconstitution, low therapeutic indices of the available drugs, and the development of viral resistance. An understanding of these processes may provide important leads for the development of improved therapy for AIDS.
Yarchoan
R
R
Medicine branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Mitsuya
H
H
Broder
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy*; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015224:Dideoxynucleosides / Q000494:pharmacology / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000276:immunology / Q000628:therapy*; D017320:HIV Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D017320:HIV Protease Inhibitors