Wilms' tumor in the Li-Fraumeni cancer family syndrome.
Scrutiny of the family pedigrees of a population-based series of 176 children diagnosed with Wilms' tumor between 1954 and 1990, along with a review of the literature on the Li-Fraumeni cancer family syndrome, indicate that Wilms' tumor may be an uncommon component of the syndrome and that a small proportion of children with Wilms' tumor may be members of Li-Fraumeni syndrome (LFS) families.
CRC Paediatric & Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, U.K.
A L
AL
Hartley
J M
JM
Birch
K
K
Tricker
S A
SA
Wallace
A M
AM
Kelsey
M
M
Harris
P H
PH
Jones
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D010375:Pedigree; D013577:Syndrome; D009396:Wilms Tumor / Q000235:genetics*