[Liver damage during administration of itraconazole (Trisporal)].
Three case histories are described of patients, two women aged 62 and 57 and a man aged 75 years, who developed symptomatic hepatic injury five to six weeks after starting itraconazole treatment. In two of them the biochemical pattern of liver injury was cholestatic. Other causes of hepatic injury were excluded. Monitoring serum liver enzymes is advisable in patients treated with itraconazole for one month or longer.
Academisch Ziekenhuis, afd. Dermatologie, Leiden.
A P
AP
Lavrijsen
K J
KJ
Balmus
W M
WM
Nugteren-Huying
A C
AC
Roldaan
J W
JW
van 't Wout
B H
BH
Stricker
D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole