Sumatriptan relieves and prevents peri-operative migraine attacks.
The novel use of sumatriptan as an adjunct to the management of general anaesthesia in patients with a history of migraine is described. In two unpremedicated patients awaiting day surgery an acute pre-operative attack of migraine was successfully terminated by the injection of sumatriptan, allowing surgery to proceed uneventfully under general anaesthesia without postoperative complications. Two other patients with a history of severe habitual vomiting after general anaesthesia, who also had a history of migraine, were each given a prophylactic injection of sumatriptan after induction of anaesthesia and for the first time emerged from general anaesthesia free of these distressing complications.
Department of Anaesthesia, Frimley Park Hospital, Surrey.
J G
JG
Hannington-Kiff
D000328:Adult; D000768:Anesthesia, General; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008875:Middle Aged; D008881:Migraine Disorders / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D018170:Sumatriptan; D014839:Vomiting / Q000517:prevention & control
D007211:Indoles; D017366:Serotonin Receptor Agonists; D013449:Sulfonamides; D018170:Sumatriptan