A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys.
The effects of a human GM-CSF/IL-3 fusion protein (PIXY321) were examined in a primate model of rebound hematopoiesis following sublethal irradiation. The results demonstrated an enhanced rate of both neutrophil and platelet regeneration, as well as functional activation of circulating neutrophils.
Department of Experimental Hematology, Immunex Corporation, Seattle, Washington 98101.
D E
DE
Williams
J T
JT
Dunn
L S
LS
Park
E A
EA
Frieden
F R
FR
Seiler
A M
AM
Farese
T J
TJ
Macvittie
D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D004355:Drug Stability; D004797:Enzyme-Linked Immunosorbent Assay; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000493:pharmacokinetics / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000378:metabolism; D007377:Interleukin-3 / Q000493:pharmacokinetics / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D011993:Recombinant Fusion Proteins / Q000493:pharmacokinetics / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D007377:Interleukin-3; C078524:PIXY321 fusion protein, recombinant; D011993:Recombinant Fusion Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006861:Hydrogen Peroxide