Overexpression of an elongation factor-1 gamma-hybridizing RNA in colorectal adenomas.
While it is apparent that colorectal carcinogenesis results from a series of genetic alterations manifested phenotypically by the adenoma-to-carcinoma sequence, the early events that occur in the process of tumorigenesis have not been elucidated. We previously demonstrated that human elongation factor-1 (EF-1) gamma-hybridizing RNA was overexpressed in 25 of 29 colorectal carcinomas. To determine if the overexpression of this mRNA occurs early in tumor development, we examined 25 adenomas and corresponding normal-appearing distant mucosae from 20 patients without familial adenomatous polyposis (FAP). We observed overexpression at a level of twofold or more in 14 (56%) of the 25 adenomas, indicating that overexpression of EF-1 gamma RNA is often a relatively early event in the development of non-FAP colorectal cancer.
Department of Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
B
B
Ender
P
P
Lynch
Y H
YH
Kim
N V
NV
Inamdar
K R
KR
Cleary
M L
ML
Frazier
D000236:Adenoma / Q000235:genetics*; D011125:Adenomatous Polyposis Coli / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D015152:Blotting, Northern; D015179:Colorectal Neoplasms / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D010445:Peptide Elongation Factors / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*
D010445:Peptide Elongation Factors; D012333:RNA, Messenger; D004247:DNA