Tricyclic dose requirements across pregnancy.
In a series of eight pregnant women, the authors found that the doses of tricyclic antidepressants required to achieve remission of symptoms and adequate serum levels increased during the second half of pregnancy. During the final trimester, the mean dose required was 1.6 times the mean dose required when the patients were not pregnant.
Pregnancy and Infant/Parent Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213.
K L
KL
Wisner
J M
JM
Perel
S B
SB
Wheeler
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000523:psychology; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third
D000929:Antidepressive Agents, Tricyclic