Treatment effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to), on autoimmune MRL/MP-lpr/lpr mice.
MRL/Mp-lpr/lpr (MRL/lpr) mice were treated with a traditional Chinese herbal medicine, Ren-shen-yang-rong-tang (Japanese name: Ninjin-youei-to, NYT) intraperitoneally (i.p.) every 3 days or per os (p.o.) 6 times/week from before the onset of autoimmune disease (6 weeks of age). Fifty percent survival time was found in placebo-controlled male and female mice of 28 and 22 weeks of age, respectively. NYT-treatment markedly prolonged the survival time of MRL/lpr mice. That is, 50% survival time was 43 weeks in the i.p.-treated male mice and 30 weeks of age in the p.o.-treated female mice. Further, NYT-treatment significantly reduced occurrence of thymic atrophy and prevented the anomalous accumulation of B220+ T-cells in lymph node and spleen, both of which are characteristic in MRL/lpr mice. Moreover, grades of proteinuria were significantly reduced in both the i.p.- and p.o.-treated groups compared with the control groups. Such clinical benefit and increased survival time were interestingly not associated with the decrease in the level of autoantibodies.
Traditional Chinese Medicine Research Laboratories, Kanebo Ltd, Osaka, Japan.
S
S
Nakai
T
T
Kawakita
N N
NN
Zhou
K
K
Matsuura
M
M
Oka
H
H
Nagasawa
Y
Y
Saito
A
A
Suzuki
K
K
Himeno
K
K
Nomoto
D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008206:Lymphatic Diseases / Q000517:prevention & control; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008817:Mice, Mutant Strains; D011507:Proteinuria / Q000188:drug therapy; D013163:Splenomegaly / Q000517:prevention & control; D013950:Thymus Gland / Q000187:drug effects
D000974:Antibodies, Antinuclear; D004365:Drugs, Chinese Herbal; C072867:ren-shen-yang-rong-tang