Regression of allopurinol-induced peripheral neuropathy after drug withdrawal.
A patient experienced an axonomyelinic peripheral neuropathy during a long-term allopurinol treatment. The symptoms and signs regressed after drug withdrawal, and the nerve conduction velocities and distal latencies improved. The incidence of allopurinol-induced peripheral neuropathy is very low. Thus, facilitatory factors have to be sought.
Clinique des Maladies du Système Nerveux, CHU Timone, Marseille, France.
J P
JP
Azulay
O
O
Blin
P
P
Valentin
P
P
Abegg
J F
JF
Pellissier
G
G
Serratrice
D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D006073:Gout / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology; D010292:Paresthesia / Q000139:chemically induced* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D011930:Reaction Time / Q000187:drug effects; D013497:Sural Nerve / Q000187:drug effects / Q000473:pathology; D009435:Synaptic Transmission / Q000187:drug effects
D000493:Allopurinol