Muslims with non-insulin dependent diabetes fasting during Ramadan: treatment with glibenclamide.
OBJECTIVE
To compare the efficacy of two glibenclamide regimens in patients with non-insulin dependent diabetes who were fasting during Ramadan and regular glibenclamide treatment in the non-fasting group.


METHODS
Non-randomised control group of patients who did not fast during Ramadan and two groups of patients who fasted randomised equally to one of two regimens: to take their usual morning dose of glibenclamide in the evening and their usual evening dose before dawn; or to follow this pattern but to reduce the total dose by a quarter.


METHODS
Two university hospitals, one private hospital, and two private clinics in Casablanca and Rabat, Morocco.


METHODS
591 diabetic patients (198 men, 391 women, two unspecified) with similar duration of diabetes and length and amount of glibenclamide treatment, of whom 542 completed the study.


METHODS
Serum fructosamine and total glycated haemoglobin concentrations and number of hypoglycaemic events.


RESULTS
At the end of Ramadan there were no significant differences between the groups in fructosamine concentration (400 mumol/l in controls and 381 mumol/l and 376 mumol/l in the fasting groups); percentage of glycated haemoglobin (14.7%, 14.0%, and 13.6%); or number of hypoglycaemic events during Ramadan (11, 14, and 10).


CONCLUSIONS
Glibenclamide is effective and safe for patients with non-insulin dependent diabetes who fast during Ramadan. The easiest regimen is to take the normal morning dose (together with any midday dose) at sunset and any evening dose before dawn.
Belkhadir
J
J
Medical Department E, University Hospital Ibn Sina, Rabat, Morocco.
el Ghomari
H
H
Klöcker
N
N
Mikou
A
A
Nasciri
M
M
Sabri
M
M
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female; D019270:Fructosamine; D005905:Glyburide / Q000008:administration & dosage / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000032:analysis; D006595:Hexosamines / Q000097:blood; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007514:Islam; D008297:Male; D008875:Middle Aged
D019270:Fructosamine; D005905:Glyburide; D006442:Glycated Hemoglobin; D006595:Hexosamines