Coincident indices of exons and introns.
In this paper, the coincident index, proposed by W. F. Friedman in cryptology, is made use of in DNA sequence analysis and exon prediction. The coincident index of exons exceeds that of introns by many times, and is mainly affected by window length, which is correlated negatively with the coincident index. An optimal exon prediction scheme was obtained by experimental analysis with an orthogonal table. Besides exons, many other special sites such as tandem repeats can be identified by using the coincident index approach. The application of this approach to the ARV-2 (AIDS associated retrovirus 2) genome found three new possible coding regions and some unusual base composition regions which are probably related to definite biological functions.
Institute of Biophysics, Academia Sinica, Beijing, P.R. China.
J
J
Xu
R
R
Chen
L
L
Ling
R
R
Shen
J
J
Sun
D001482:Base Composition; D003062:Codon; D004247:DNA / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005091:Exons / Q000235:genetics*; D005796:Genes; D016679:Genome, Viral; D006801:Humans; D007438:Introns / Q000235:genetics*; D008433:Mathematics; D017422:Sequence Analysis, DNA / Q000379:methods* / Q000706:statistics & numerical data
D003062:Codon; D004279:DNA, Viral; D004247:DNA