Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer.
We evaluated the prognostic significance of p53 mutations and an allelic loss of chromosome 3p in 71 patients with non-small cell lung cancer who underwent potentially curative resection. p53 mutations were detected in 35 cases (49%), while 3p deletions were observed in 34 of 70 informative cases (49%). The presence of the p53 mutation was associated with a shortened survival in all patients (P = 0.014 by log rank test), including those in early stages of the disease (stage I or II, n = 48) (P = 0.016 by log rank test). Multivariate analysis by the Cox proportional hazards model also revealed that p53 mutation was an independent yet unfavorable prognostic factor (P = 0.013). Patients with 3p deletion tended to have a poorer prognosis, but not to a statistically significant extent.
Laboratory of Immunology, Aichi Cancer Center Research Institute, Japan.
Y
Y
Horio
T
T
Takahashi
T
T
Kuroishi
K
K
Hibi
M
M
Suyama
T
T
Niimi
K
K
Shimokata
K
K
Yamakawa
Y
Y
Nakamura
R
R
Ueda
D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000601:surgery; D002893:Chromosomes, Human, Pair 3 / Q000502:physiology*; D005260:Female; D017353:Gene Deletion; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D011379:Prognosis