Increased transcription of interleukin-6 in the brains of mice with chronic enterovirus infection.
An animal model of chronic enteroviral infection was established by using PCR to detect viral genomes in animal tissues and to compare levels of transcription of a variety of cytokines in the brain. Chronic coxsackie-virus B1 infection was found in both brain and skeletal muscle of mice infected as neonates. The viral infection cleared by 240 days post-infection. Elevated levels of tumour necrosis factor alpha and interleukin-6 (IL-6) would appear to be linked to acute and chronic infection respectively. Levels of IL-6 return to normal upon clearance of the virus.
University of Glasgow, Department of Neurology, Southern General Hospital, U.K.
J S
JS
Gillespie
H M
HM
Cavanagh
W M
WM
Behan
L J
LJ
Morrison
F
F
McGarry
P O
PO
Behan
D000818:Animals; D001921:Brain / Q000382:microbiology*; D002908:Chronic Disease; D003384:Coxsackievirus Infections / Q000235:genetics*; D029822:Enterovirus B, Human; D015870:Gene Expression; D015850:Interleukin-6 / Q000235:genetics*; D007378:Interleukins / Q000235:genetics; D051379:Mice; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D015850:Interleukin-6; D007378:Interleukins; D012333:RNA, Messenger