Comparative renal hemodynamic effects of lisinopril, verapamil, and amlodipine in patients with chronic renal failure.
We investigated the effects of lisinopril, verapamil, and amlodipine in 26 hypertensive patients with chronic renal disease of varying etiologies. Blood pressure, urine protein excretion, glomerular filtration rate (GFR), and renal blood flow (RBF) (inulin and para-aminohippurate clearance) were determined before and after 2 to 3 months of therapy. All three agents lowered blood pressure with minimal side effects in many, but not all, patients. Patients who had a significant lowering of blood pressure in response to lisinopril and verapamil had favorable renal hemodynamic responses as well--GFR remained stable, RBF was stable or increased, and filtration fraction, renal vascular resistance, and proteinuria tended to decrease. Patients whose blood pressure did not decrease had less favorable responses. In the small number of patients who received amlodipine, lowering of blood pressure was associated with a small decrease in GFR. Our results demonstrate a heterogeneity in response to antihypertensive agents in patients with renal disease. We therefore conclude that treatment of such patients should be individualized, and suggest that choice of therapy depend on adequate blood pressure response in conjunction with stabilization of renal function and urine protein excretion. Our data do not support the use of a drug in these circumstances if it does not lower systemic blood pressure.
August
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Cardiovascular Center, New York Hospital-Cornell Medical Center, New York 10021.
Lenz
T
T
Laragh
J H
JH
D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004151:Dipeptides / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*; D017706:Lisinopril; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011507:Proteinuria / Q000652:urine; D012079:Renal Circulation / Q000187:drug effects*; D012083:Renin / Q000097:blood; D014700:Verapamil / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D004151:Dipeptides; D017311:Amlodipine; D014700:Verapamil; D017706:Lisinopril; D012083:Renin; D011188:Potassium