Reduced [3H]SCH 23390 binding and DA-sensitive adenylyl cyclase in the limbic system of ethanol-preferring rats.
Dopamine (DA) D1 receptors and the response of adenylyl cyclase (AC) to dopamine stimulation were studied in the limbic areas and the caudate-putamen of Sardinian ethanol-preferring (SP), Sardinian ethanol-non-preferring (SNP) and Wistar unselected (UW) rats. SP rats exhibited a significantly lower number of D1 receptors, measured using [3H]SCH 23390 binding, and a decreased response to DA stimulation than SNP and UW animals. Since SP rats have also a lower number of D2 receptors, the results suggest that an altered dopaminergic transmission may underlie their innate alcohol preference.
Institute of Pharmacology, University of Siena, Italy.
M G
MG
De Montis
C
C
Gambarana
G L
GL
Gessa
D
D
Meloni
A
A
Tagliamonte
E
E
Stefanini
D000262:Adenylyl Cyclases / Q000378:metabolism; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D001552:Benzazepines / Q000493:pharmacokinetics*; D002421:Caudate Nucleus / Q000503:physiopathology; D008032:Limbic System / Q000503:physiopathology*; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D011699:Putamen / Q000503:physiopathology; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D017447:Receptors, Dopamine D1 / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D013570:Synaptic Membranes / Q000502:physiology
D001552:Benzazepines; D017447:Receptors, Dopamine D1; D000262:Adenylyl Cyclases