Results of bone marrow transplants from human leukocyte antigen-identical sibling donors for treatment of childhood leukemias. A report from the International Bone Marrow Transplant Registry.
OBJECTIVE
Bone marrow transplantation is an effective treatment for leukemia. Cures are possible in 20-80% of transplant recipients depending on the stage of leukemia at the time of transplant. The antileukemia efficacy of transplants result from high-dose chemotherapy and/or radiation given pretransplant and from immune-mediated effects of the graft.


RESULTS
Success of the procedure is limited by transplant-related complications, including graft rejection, graft-vs.-host disease and interstitial pneumonia. Five-year leukemia-free survival ranges from approximately 25% for children transplanted with advanced leukemia, to > 60% in those transplanted in first remission of acute leukemia or first chronic phase of chronic myeloid leukemia.


CONCLUSIONS
Candidates for transplant include children failing conventional therapy and, possibly, those with early leukemia characterized by features predicting a poor response to conventional therapy.
Horowitz
M M
MM
International Bone Marrow Transplant Registry, Medical College of Wisconsin, Milwaukee 53226.
Bortin
M M
MM
D000206:Actuarial Analysis; D000741:Anemia, Aplastic / Q000601:surgery; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology / Q000706:statistics & numerical data*; D002648:Child; D003131:Combined Modality Therapy; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000209:etiology; D030342:Genetic Diseases, Inborn / Q000601:surgery; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000453:epidemiology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007391:International Cooperation; D007938:Leukemia / Q000601:surgery*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000401:mortality / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000401:mortality / Q000628:therapy; D009679:Nuclear Family; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000401:mortality / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000453:epidemiology / Q000209:etiology; D012042:Registries; D012074:Remission Induction; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D006680:HLA Antigens