[Experimental reconstruction of the mediastinal trachea with autogenous material-hydroxyapatite-omentum complex].
Reconstruction of extensive tracheal defects remains a difficult surgical problem. An experiment with one stage reconstruction of the thoracic trachea was performed in 32 adult mongrel dogs using a complex consisted of 3 layers as follows; autogenous materials as the inner layer, Hydroxyapatite (HA) ring as the middle layer, pedicled omental flap as the outer layer. Mediastinal tracheal defects (3-5 rings) were created and primarily reconstructed with the autogenous materials (Group 1: Pericardium, Group 2: Full thickness skin), supported with horseshoe-shaped HA rings, then covered with the pedicled omental flap. In the tracheal lumen a temporary silicone tube stent was inserted, and following groups were provided according to the duration of insertion of the stent: Group 1a:1 week, Group 1b:6 weeks, Group 1c:6 months in the cases of pericardium, Group 2a:1 week and Group 2b:6 weeks in the cases of skin graft. Three were the cases of early death. In Group 1a (n = 4) and Group Ib (n = 8), severe or moderate stenosis was noted in most cases. In Group 1c (n = 7), no stenosis occurred and ciliated epithelium was seen in 2 dogs, however, stenosis occurred moderately in 3 dogs and severe in 2. In group 2a (n = 8), moderate stenosis was seen in 1 dog due to the displacement of HA ring. No stenosis occurred in 7 other dogs. In Group 2b (n = 2), HA rings had been naked due to necrosis or infection of the skin graft in both cases.(ABSTRACT TRUNCATED AT 250 WORDS)
Oizumi
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Second Department of Surgery, Yamagata University School of Medicine, Japan.
D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D017886:Durapatite; D005240:Feasibility Studies; D006882:Hydroxyapatites; D009852:Omentum / Q000637:transplantation*; D019736:Prostheses and Implants; D015607:Stents; D014132:Trachea / Q000473:pathology / Q000601:surgery*; D014135:Tracheal Stenosis / Q000209:etiology / Q000473:pathology
D001672:Biocompatible Materials; D006882:Hydroxyapatites; D017886:Durapatite