Recurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization.
Donor cell leukemia after BMT has been documented in a small number of cases mainly by cytogenetic studies. We describe a case of leukemia relapse in a 16-year-old girl 1 year after BMT from her histocompatible brother. Relapse in donor cells was initially suspected on the basis of cytogenetic analysis and confirmed by DNA in situ hybridization in blast cells using a Y chromosome-specific probe.
Mouratidou
M
M
Hematology Division, Greek Anticancer Institute Athens.
Sotiropoulos
D
D
Deremitzaki
K
K
Spathas
D H
DH
Hoffbrand
A V
AV
Prentice
H G
HG
Papanastasiou
K
K
Tsakanikas
S
S
Tsaftaridis
P
P
Stamatelou
M
M
D000293:Adolescent; D000951:Antigens, Neoplasm; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000276:immunology / Q000601:surgery*; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000276:immunology; D012008:Recurrence; D014019:Tissue Donors; D014998:Y Chromosome
D000951:Antigens, Neoplasm; D015342:DNA Probes; D004273:DNA, Neoplasm