Long-term results after percutaneous retrogasserian glycerol rhizotomy in patients with trigeminal neuralgia.
We have evaluated the long-term results of percutaneous retrogasserian glycerol rhizotomy (PRGR) in 60 patients with classical trigeminal neuralgia. Complete initial pain relief was achieved in 93% of the patients. Numbness was initially reported by 3/4 of the patients and at follow-up by 1/3, while long-lasting dysaesthesias were an important side effect in 38% of previously untreated patients. The half-life of the method was 47 months in our material, and this figure compares favourably with other previously reported series. The method carries a significant risk of long-lasting and troublesome sensory disturbances. Another disadvantage of the method, reported in the present long-term study, was the high incidence of recurrent neuralgia. We are unable to identify predictors of recurrent neuralgia after PRGR, although major recurrences were more common in patients with unchanged facial sensation postoperatively. In conclusion, PRGR offers safe and reliable relief of pain in patients with trigeminal neuralgia. In spite of the high incidence of recurrence and of long-lasting dysaesthesias it is, in our opinion, the method of choice in the elderly, and particularly suitable for patients at high risk.
Department of Neurosurgery, Rikshopitalet, National Hospital, Oslo, Norway.
H
H
Slettebø
H
H
Hirschberg
K F
KF
Lindegaard
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005990:Glycerol / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012008:Recurrence; D013126:Spinal Nerve Roots / Q000187:drug effects*; D016896:Treatment Outcome; D012668:Trigeminal Ganglion / Q000187:drug effects*; D014277:Trigeminal Neuralgia / Q000628:therapy*
D005990:Glycerol