[The ornithine decarboxylase activity of the epidermis in psoriasis as a biochemical index of the hyperproliferative process].
The mean levels of activity of the key enzyme of polyamine biosynthesis, ornithine decarboxylase, in epidermis damaged by psoriasis were 6-fold higher than in normal epidermis. In contrast to the literature data, the activity of the enzyme in uninvolved psoriatic epidermis was also 4-fold higher on DNA basis than that in normal human epidermis. The data obtained suggest that determination of the ornithine decarboxylase activity in epidermis might be considered as the enzyme test for measuring of any hyperproliferative process in the skin, including psoriasis. The inductive synthesis of ornithine decarboxylase is both early and possibly mandatory specific biochemical property of hyperproliferative process of any etiology.
Kagramanova
A T
AT
Tishchenko
L D
LD
Berezov
T T
TT
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002455:Cell Division / Q000502:physiology; D004817:Epidermis / Q000737:chemistry / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008115:Liver Regeneration / Q000502:physiology; D009955:Ornithine Decarboxylase / Q000032:analysis / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism; D011565:Psoriasis / Q000201:enzymology*; D051381:Rats
D015415:Biomarkers; D011073:Polyamines; D009955:Ornithine Decarboxylase