Successful treatment of concomitant pulmonary nocardiosis and aspergillosis in an immunocompromised renal patient.
A case is reported of rapid onset concomitant pulmonary infection with Nocardia and Aspergillus fumigatus in a patient six weeks after the institution of immunosuppressive therapy for renal vasculitis. Pulmonary lesions completely resolved on treatment with a combination of imipenem, cotrimoxazole and a prolonged course of itraconazole.
Holt
R I
RI
Department of Nephrology, Royal London Hospital & Medical College, Whitechapel, UK.
Kwan
J T
JT
Sefton
A M
AM
Cunningham
J
J
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications; D015378:Imipenem / Q000627:therapeutic use; D016867:Immunocompromised Host; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008168:Lung / Q000000981:diagnostic imaging; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy; D008297:Male; D009617:Nocardia Infections / Q000150:complications / Q000188:drug therapy*; D011014:Pneumonia / Q000188:drug therapy* / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D006435:Renal Dialysis; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000935:Antifungal Agents; D017964:Itraconazole; D015378:Imipenem; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide; D011239:Prednisolone; D007654:Ketoconazole