Anaplastic large-cell Ki-1 lymphoma. Pulmonary presentation mimicking miliary tuberculosis.
An unusual presentation of anaplastic large-cell (ALC) Ki-1 lymphoma is described, in which pulmonary involvement mimicked miliary tuberculosis. Lung involvement is uncommon in this type of lymphoma, and it is not clear from previous reports whether this was a presenting feature. Bone marrow involvement, rare in Ki-1 lymphoma, also was present in this case. Despite therapy skin involvement subsequently developed, and the patient died 3 months after presentation. Postmortem examination revealed lymphomatous involvement of the heart, liver, kidneys, stomach, and lymph nodes. This case highlights the need for awareness of ALC Ki-1 lymphoma particularly when it presents at uncommon extranodal sites.
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P M
PM
Department of Anatomical Pathology, University of Cape Town, South Africa.
Macrae
M B
MB
Hammond
J M
JM
Aronson
I
I
Johnson
C A
CA
Potgieter
P D
PD
Jacobs
P
P
D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D001344:Autopsy; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen; D007668:Kidney / Q000473:pathology; D017493:Leukocyte Common Antigens / Q000032:analysis; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000473:pathology; D012867:Skin / Q000737:chemistry / Q000473:pathology; D013270:Stomach / Q000473:pathology; D014391:Tuberculosis, Miliary / Q000175:diagnosis* / Q000473:pathology
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen; D017493:Leukocyte Common Antigens