Results of two years of growth hormone treatment followed by combined growth hormone and oestradiol in Turner syndrome. The Norwegian Turner Study Group.
The effects of treatment with human growth hormone (GH) for 2 years, followed by combined treatment with GH and oestradiol valerate, were studied in girls with Turner syndrome, aged 7.0-16.6 years. Height SDS (Turner standards) increased after GH treatment, and height velocity SDS (Turner standards) increased dramatically 6 months after the start of GH treatment and gradually declined after 2 years' treatment. A further increase occurred after 18 months of GH and oestradiol treatment in conjunction with the pubertal growth spurt, followed by a decline 6 months later. Height SDS for bone age increased during GH treatment, and remained virtually unchanged after the introduction of oestradiol. Predicted final height increased after the first year of GH treatment only. The use of GH and oestrogen treatment in Turner syndrome is discussed in the light of these preliminary results.
Department of Pediatrics, University of Bergen, Oslo, Norway.
J
J
Knudtzon
D
D
Aarskog
D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000097:blood; D009664:Norway; D011627:Puberty / Q000187:drug effects; D011795:Surveys and Questionnaires; D014424:Turner Syndrome / Q000188:drug therapy* / Q000523:psychology
D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone