[Evaluation of renal function using 99mTc-MAG3: comparison with 123I-OIH and 99mTc-DTPA].
The utility of 99mTc-mercaptoacetyltriglycine (MAG3) with studied clinically. In the renography obtained with 99mTc-MAG3, the abdominal aorta and the common iliac arteries were clearly visualized in the vascular phase. Due to less background activity and high target to background ratio, the quality of 99mTc-MAG3 image was superior to that of 123I-OIH or 99mTc-DTPA image. The parameters on the renogram including Tmax, T2/3, and T1/2 were compared. The correlation of Tmax and T2/3 or T1/2 were not significant between 99mTc-MAG3 and 123I-OIH. Another parameter of C20/Cmax, where C20 and Cmax are renal activities at 20 min after injection and at Tmax respectively, showed an excellent correlation between 99mTc-MAG3 and 123I-OIH. Using C20/Cmax, pattern of renogram can be characterized numerically. Concerning about the relation between C20/Cmax and renogram pattern, standard renogram pattern showed the C20/Cmax value of less than 0.4, while hypofunctioning pattern showed more than 0.5. The correlation coefficient between the renal uptake of 99mTc-MAG3 and 123I-OIH was 0.880 with a correlation plot: "Y = 1.16X-0.043", where X and Y represent renal uptake of 99mTc-MAG3 and 123I-OIH, respectively. It can be concluded that 99mTc-MAG3 is useful renal imaging agent as an alternative to 123I-OIH, in order to evaluate the proximal tubular function and calculate ERPF.
Kanazawa University, School of Medicine.
T
T
Takayama
T
T
Aburano
N
N
Shuke
K
K
Yokoyama
T
T
Michigishi
B F
BF
Sun
N
N
Tonami
K
K
Hisada
T
T
Takabatake
H
H
Ohta
D000328:Adult; D000368:Aged; D005919:Glomerular Filtration Rate; D006801:Humans; D007457:Iodine Radioisotopes; D007668:Kidney / Q000503:physiopathology*; D008875:Middle Aged; D011866:Radioisotope Renography; D012079:Renal Circulation; D017263:Technetium Tc 99m Mertiatide; D016284:Technetium Tc 99m Pentetate; D014570:Urologic Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology
D007457:Iodine Radioisotopes; D017263:Technetium Tc 99m Mertiatide; D016284:Technetium Tc 99m Pentetate