Tumor viruses in CD30-positive anaplastic large cell lymphomas.
CD30+ anaplastic large cell lymphoma (ALCL) represents a novel lymphoma entity at the borderline between Hodgkin's disease and non-Hodgkin's lymphomas. Phenotypic, genotypic, and karyotypic analyses have shown that ALCL are heterogeneous in cellular origin, and may be conceived as malignancies derived from activated, mainly T- or B-lymphoid cells, in some instances with an immature genotype. Epstein-Barr virus genomes and gene products, most notably the transformation-associated latent membrane protein (LMP), have been detected in a proportion of cases, and some cutaneous ALCL proved to harbor complete or incomplete HTLV-1 proviruses. These findings suggest that both EBV and HTLV-I, which are powerful inducers of CD30 expression in lymphoid cells in vitro, may contribute to the pathoetiology of ALCL.
Herbst
H
H
Institute of Pathology, Klinikum Steglitz, Free University Berlin, Germany.
Stein
H
H
D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis* / Q000096:biosynthesis; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000096:biosynthesis; D002277:Carcinoma / Q000737:chemistry / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D015490:HTLV-I Infections / Q000382:microbiology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D017730:Ki-1 Antigen; D008213:Lymphocyte Activation; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000382:microbiology*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000737:chemistry / Q000382:microbiology; D009363:Neoplasm Proteins / Q000032:analysis* / Q000096:biosynthesis; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000382:microbiology; D012191:Retroviridae Proteins / Q000032:analysis / Q000235:genetics; D012878:Skin Neoplasms / Q000382:microbiology*; D014412:Tumor Virus Infections / Q000382:microbiology*; D014764:Viral Proteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D004279:DNA, Viral; D017730:Ki-1 Antigen; D009363:Neoplasm Proteins; D012191:Retroviridae Proteins; D014764:Viral Proteins