Design, synthesis and some uses of receptor-specific agonists and antagonists of vasopressin and oxytocin.
Selective agonists and antagonists are powerful tools for studies on AVP and OT receptors and on the physiological and pathophysiological roles of AVP and OT. Here we show how some of these peptides and their radiolabelled derivatives were designed. We also present examples of the currently available cyclic and linear OT and AVP agonists and antagonists from our laboratories.
Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo 43699-0008.
M
M
Manning
W H
WH
Sawyer
D000595:Amino Acid Sequence; D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D015198:Designer Drugs / Q000627:therapeutic use; D015195:Drug Design; D008969:Molecular Sequence Data; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011869:Radioligand Assay; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin / Q000187:drug effects*
D065092:Antidiuretic Hormone Receptor Antagonists; D015198:Designer Drugs; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D010121:Oxytocin