[Diclofenac does not change the characteristics of anesthetic induction with midazolam].
To examine the possible interaction between diclofenac and midazolam, 20 patients undergoing orthopedic or traumatologic surgery were studied. All were anesthetized with 0.3 mg/kg intravenous midazolam after having been premedicated randomly with either placebo (control group, n = 10) or with 1 mg/kg intravenous diclofenac (n = 10). Anesthetic characteristics (rate of induction and depth) were similar in both groups, indicating that no clinical interaction between the two drugs can be identified.
Departamento de Anestesiología y Reanimación, Hospital Clínic i Provincial, Barcelona.
E
E
Carrero
J
J
Castillo
A
A
Bogdanovich
C
C
Lapena
M A
MA
Nalda
D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D004008:Diclofenac / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D011229:Preanesthetic Medication
D004008:Diclofenac; D008874:Midazolam