Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas.
Department of Pathology, Gade Institute, Bergen, Norway.
L A
LA
Akslen
A O
AO
Myking
H
H
Salvesen
J E
JE
Varhaug
D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology
D066246:ErbB Receptors