Relationship between 90-kilodalton heat shock protein, estrogen receptor, and progesterone receptor in human mammary tumors.
To determine, if, as previously observed with rodent uterus, the 90 kilodalton heat shock protein (HSP-90) might be under estrogenic regulation in human mammary tumors, we analyzed its relationship with estrogen and progesterone receptors. A positive relationship between estrogen receptor and HSP-90 was observed when these were normalized to HSP-70 levels (to normalize for the intrinsic variations in each tumor, independent of any hormonal dependence).
Cell & Molecular Biology Department, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720.
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Shyamala
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Schweitzer
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SJ
Ullrich
D001943:Breast Neoplasms / Q000737:chemistry* / Q000648:ultrastructure*; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D006360:Heat-Shock Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone