Arterial bridging for repair of peripheral nerve gap: a comparative study.
A new experimental model was designed in which the regeneration of rat femoral nerve across a 8 mm excised gap was investigated after insertion of the distal and proximal stumps into the anatomically and functionally intact femoral artery (AIAB). This model was compared with groups of free artery and autologous nerve grafting. After a period of 12 weeks, a histological and electrophysiological analysis was carried out, which demonstrated that the AIAB and autologous nerve grafting group had a significantly higher percentage of regeneration compared with the free artery-graft group. The nerve regeneration and intraneural vascular reconstruction that occurred within AIAB group were more successful than those that occurred in the artery and nerve-grafting groups.
Cataltepe
O
O
Department of Neurosurgery, Hacettepe University Medical School, Ankara, Turkey.
Ozcan
O E
OE
Onur
R
R
Demirhan
B
B
Ruacan
S
S
Erbengi
A
A
D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D001158:Arteries / Q000473:pathology / Q000637:transplantation*; D001369:Axons / Q000473:pathology / Q000502:physiology; D005263:Femoral Artery / Q000637:transplantation; D005267:Femoral Nerve / Q000473:pathology / Q000601:surgery; D008866:Microsurgery / Q000379:methods*; D009416:Nerve Regeneration / Q000502:physiology*; D010525:Peripheral Nerves / Q000473:pathology / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000502:physiology*; D014945:Wound Healing