Wilms tumor in a patient with Prader-Willi syndrome.
The development of Wilms tumor in a patient with Prader-Willi syndrome prompted us to determine the parental origin of the genes implicated in both disorders because of the sex-specific parent-of-origin effects previously demonstrated for both conditions. A paternal chromosome 15q11-q13 deletion was demonstrated, but no changes were demonstrated in a limited analysis of chromosome 11p, which harbors two Wilms tumor suppressor genes, WT1 and WT2.
Coppes
M J
MJ
Department of Cancer Biology, Cleveland Clinic Foundation, Ohio.
Sohl
H
H
Teshima
I E
IE
Mutirangura
A
A
Ledbetter
D H
DH
Weksberg
R
R
D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications / Q000235:genetics*; D008297:Male; D011218:Prader-Willi Syndrome / Q000150:complications / Q000235:genetics*; D009396:Wilms Tumor / Q000150:complications / Q000235:genetics*