Effects of ciprofloxacin and enrofloxacin on zoxazolamine kinetics, plasma concentration and sleeping times in mice.
The treatment of CD1 male mice with either ciprofloxacin (CP) or enrofloxacin (EF) prior to zoxazolamine (ZX) administration increased the mean ZX sleeping times to, respectively, 162 and 156% of the control (ZX alone). At the end of the sleeping time, the mean ZX plasma concentration in controls was 27.2 micrograms/ml and was not different in EF- or CP-treated groups (87% and 95% of controls, respectively). The animals coadministered with CP or EF and ZX eliminated the latter more slowly than the controls. The estimated zero-time drug concentration of the disposition curves of both the CP- and EF-treated groups as well as the apparent half-life of elimination and apparent overall rate of elimination of the CP-treated group were different from the control values.
Department of Pharmacology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
P M
PM
Vancutsem
J G
JG
Babish
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000494:pharmacology*; D004347:Drug Interactions; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D015363:Quinolones / Q000494:pharmacology*; D012021:Reflex, Abnormal / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D015049:Zoxazolamine / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D002939:Ciprofloxacin; D015049:Zoxazolamine