Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24.
The authors examined the dose response relationship between plasma ACTH and cortisol concentrations after the administration of various doses of ACTH1-24 (0.025 micrograms, 0.125 micrograms, 0.25 micrograms, 1 microgram, 250 micrograms) in dexamethasone-suppressed normal volunteers. A logarithmic dose-response relationship between the dose of ACTH administered and plasma cortisol concentration was found. Although there was considerable variability in plasma ACTH concentrations, there was, however, a definite correlation between area under the curve for ACTH and area under the curve for cortisol after the various doses of ACTH.
Department of Psychiatry, Duke University Medical Center, Durham, NC.
K R
KR
Krishnan
M N
MN
Miller
M J
MJ
Helms
D
D
Reed
J C
JC
Ritchie
C B
CB
Nemeroff
B J
BJ
Carroll
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003366:Cosyntropin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects; D012016:Reference Values
D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone