Effect of okadaic acid on leukocyte movement.
The effect of Okadaic acid (OA), a potent inhibitor of intracellular phosphatases, on neutrophil movement was studied. 1) Random movement was suppressed by OA at a concentration of 200 ng/ml. 2) Chemotaxis was suppressed by OA at concentrations between 50 and 100 ng/ml and completely suppressed at concentrations above 200 ng/ml. 3) Phagocytosis (latex particles) was suppressed by OA at concentrations more than 100 ng/ml.
Department of Bacteriology, Osaka City University Medical School, Japan.
M
M
Yokota
N
N
Tatsumi
I
I
Yano
D000293:Adolescent; D000328:Adult; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004988:Ethers, Cyclic / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D019319:Okadaic Acid; D010587:Phagocytosis / Q000187:drug effects; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*
D004988:Ethers, Cyclic; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases