Intraocular extracellular cyclic nucleotide concentrations: the influence of vitreous surgery.
Levels of cAMP (23.1 pmol/ml) and cGMP (22.6 pmol/ml) are nearly equal in normal rabbit vitreous, although aqueous cAMP levels (29.9 pmol/ml) are 10 times higher than aqueous cGMP levels (2.6 pmol/ml) (P < 0.01). Intravitreal cAMP values decrease slightly 1 week after vitrectomy and lensectomy and return to normal whether the retina is attached, detached, or surgically removed. In contrast, intravitreal cGMP levels are profoundly depressed at 7 days (approximating normal aqueous levels) and are more than 50% lower than normal 30-42 days after surgery. The presence of these cyclic nucleotides in intraocular fluid and their responsiveness after surgery may signify a potential regulatory role in the physiologic responses of the eye to retinal detachment and its repair.
Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.
J
J
Dalma-Weiszhauz
M
M
Blumenkranz
M
M
Hartzer
E
E
Hernandez
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D008297:Male; D011817:Rabbits; D012163:Retinal Detachment / Q000378:metabolism; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
D000242:Cyclic AMP; D006152:Cyclic GMP