Leydig cell tumor: a case report with reference to its endocrinological features.
We reported an adult case of Leydig cell tumor, which demonstrated an increase of serum estradiol (E2) and suppression of serum testosterone (T) before orchiectomy. The direct inhibitory action of the elevated E2 on the enzymes involved in steroidogenesis and the negative feedback action on luteinizing hormone (LH) secretion of the E2 possibly caused the suppression of serum T. A human chorionic gonadotropin test before the operation revealed the elevation of T and E2, although the response was poor compared with that in normal subjects. However, the postoperative test showed no elevation of these hormones. This result may indicate that the Leydig cell tumor preserves a response to LH stimulation.
Department of Urology, Sapporo Medical College, Japan.
N
N
Masumori
Y
Y
Kumamoto
N
N
Itoh
T
T
Tsukamoto
N
N
Miyao
M
M
Koroku
T
T
Hirose
S
S
Takahashi
D006063:Chorionic Gonadotropin; D002996:Clomiphene; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006728:Hormones / Q000097:blood*; D006801:Humans; D007984:Leydig Cell Tumor / Q000097:blood* / Q000473:pathology / Q000601:surgery; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D010901:Pituitary Function Tests; D013736:Testicular Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D006728:Hormones; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone