The release of the marked insulin J125 from ointment in vitro and in vivo.
The ointments with marked insulin J125 were prepared on suitable ointment bases. The dynamics of the released insulin from ointment in vitro and in vivo was analyzed. It has been noticed that the most of the marked insulin J125 was released in vitro and in vivo from eucerin and that there is a correlation between the amount of released insulin from ointment basis in vitro and in vivo.
Department of Applied Pharmacy and Drug Technology, Medical Silesian Academy, Sosnowies, Poland.
F
F
Ryszka
B
B
Galoch
B
B
Dolinska
G
G
Zientarska
D000818:Animals; D007328:Insulin / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes; D008297:Male; D009824:Ointments; D051381:Rats; D017208:Rats, Wistar; D013552:Swine
D007328:Insulin; D007457:Iodine Radioisotopes; D009824:Ointments