On the potential role of proopiomelanocortin in skin physiology and pathology.
Pro-opiomelanocortin (POMC) is the precursor of ACTH, alpha-MSH and beta-endorphin, neuropeptides with multiple regulatory functions. Both the pituitary gland and peripheral tissues such as mammalian skin are capable of generating POMC-derived neuropeptides. Mammalian skin is also a target for POMC products; their possible roles in skin physiology and pathology are discussed in this communication.
Slominski
A
A
Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, New York 12208.
Paus
R
R
Wortsman
J
J
D000595:Amino Acid Sequence; D000818:Animals; D016384:Consensus Sequence; D005786:Gene Expression Regulation; D006801:Humans; D008322:Mammals / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D015213:Neuroimmunomodulation / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D011333:Pro-Opiomelanocortin / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D011956:Receptors, Cell Surface / Q000502:physiology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D012880:Skin Pigmentation / Q000502:physiology
D009479:Neuropeptides; D011956:Receptors, Cell Surface; D011333:Pro-Opiomelanocortin