Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population.
An association study of the insertion/deletion (I/D) polymorphism located in intron 16 of the ACE gene with essential hypertension in the Japanese population was performed. The 287 bp I/D polymorphism was detected by polymerase chain reaction. Derived allele frequencies for insertion and deletion were not significantly different between 133 hypertensive and 104 normotensive subjects. A significant relationship between I/D polymorphism and plasma ACE activity was observed in the normotensive group, but not in hypertensives. These results suggest that I/D polymorphism of the gene is not implicated in Japanese hypertensive subjects, and that studies involving various ethnic groups are important.
Department of Geriatric Medicine, Osaka University Medical School, Japan.
K
K
Higashimori
Y
Y
Zhao
J
J
Higaki
A
A
Kamitani
T
T
Katsuya
J
J
Nakura
T
T
Miki
H
H
Mikami
T
T
Ogihara
D000328:Adult; D001483:Base Sequence; D004277:DNA, Single-Stranded; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D007564:Japan; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D004277:DNA, Single-Stranded; D007703:Peptidyl-Dipeptidase A