Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers.
Proton-decoupled, 31P three-dimensional (3-D) chemical shift imaging (CSI) spectra have been acquired from the entire human brain using a new dual tuned resonator. The resonator operates in quadrature mode to provide improved sensitivity, excellent B1 homogeneity and reduced power deposition at both frequencies. Proton-decoupled and fully NOE enhanced, 31P spectra were acquired from normal volunteers using Waltz-4 proton decoupling with continuous wave bi-level excitation applied through a second radio frequency channel. Well resolved peaks in the phosphomonoester (PME) and phosphodiester regions were obtained from nonlocalized FIDs and spectra localized with 3-D CSI without processing for resolution enhancement. pH measurements made over large regions of the brain using the P(i) resonance show no significant variations (6.9 +/- 0.02) for a single individual. The improved spectral resolution and sensitivity of the PME resonances results in more well defined metabolite images of the PME peak region.
Murphy-Boesch
J
J
Department of NMR, Fox Chase Cancer Center, Philadelphia, PA 19111.
Stoyanova
R
R
Srinivasan
R
R
Willard
T
T
Vigneron
D
D
Nelson
S
S
Taylor
J S
JS
Brown
T R
TR
D001921:Brain / Q000033:anatomy & histology*; D001923:Brain Chemistry; D005997:Glycerylphosphorylcholine / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010710:Phosphates / Q000032:analysis; D010714:Phosphatidylethanolamines / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus; D011522:Protons
D010710:Phosphates; D010714:Phosphatidylethanolamines; D011522:Protons; D010725:Phosphocreatine; C002449:glycerophosphoethanolamine; D010758:Phosphorus; D005997:Glycerylphosphorylcholine