[Acute pharmacological block of the renin-angiotensin system and the recovery of intrarenal hemodynamics in patients with chronic glomerulonephritis].
A test with capoten, inhibitor of angiotensin-converting enzyme, was employed to assess intrarenal hemodynamics (renal functional reserve-RFR) in 17 patients with morphologically confirmed chronic glomerulonephritis (CGN) in intact renal function without hypertension. Capoten induced three types of changes: RFR increased (9 cases, 7 patients recovered RFR), RFR without changes (5 cases), RFR decreased (3 cases, 2 patients lost RFR). It is stated that indications to inhibitors of angiotensin-II-converting enzyme in CGN should be based on the initial intrarenal hemodynamics and its changes in response to acute capoten test. Capoten is to be administered in initially reduced or absent RFR and is not to the used in normal RFR without hypertension and functioning kidneys. RFR recovery in the acute capoten test allows long-term treatment with inhibitors of angiotensin-converting enzyme.
Kutyrina
I M
IM
Tareeva
I E
IE
Zverev
K V
KV
Rogov
V A
VA
D000293:Adolescent; D000328:Adult; D002216:Captopril / Q000627:therapeutic use; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000187:drug effects*
D002216:Captopril