HLA-B8,DR3 phenotype and the antibody response against Epstein-Barr virus.
Antibodies against the viral capsid antigen (VCA) and nuclear antigens (EBNAs) of the Epstein-Barr virus (EBV) were determined in a sample of Sicilian population. A significant correlation was observed between HLA-B8,DR3 phenotype and reduced titres of antibodies to EBNAs, whereas HLA-B8,DR3 positive individuals displayed levels of antibodies to VCA comparable to those of HLA-B8,DR3 negative ones. These results further strengthen the suggestion that HLA-B8,DR3 positive subjects are low responders and that the depth of immune response depends on the fashion of antigenic challenge.
Istituto di Patologia generale, Università di Palermo, Italy.
C
C
Caruso
G
G
Candore
A T
AT
Colucci
D
D
Cigna
F
F
Sammartano
P
P
Ammatuna
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D036022:Capsid Proteins; D004268:DNA-Binding Proteins / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D020022:Genetic Predisposition to Disease; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D006239:Haplotypes; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012802:Sicily
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D007074:Immunoglobulin G