[Radiation therapy of nasopharyngeal carcinoma: treatment results and prognostic factors].
Between September 1977 and December 1989, 89 consecutive patients with nasopharyngeal carcinoma were treated with radiation therapy. The study included 66 men and 23 women whose ages ranged from 17 to 80 years (mean, 55 years). Five-year survival rates according to stage were as follows: Stage I + II (n = 10), 90%; Stage III (n = 10), 43%; Stage IV (n = 65), 47%. Important factors for predicting poor prognosis in this series, as were shown by the stepwise proportional hazard (Cox) model, were the level of lactate dehydrogenase (LDH) and neck node involvement (Ho's classification). LDH level also influenced nodal failure (p = 0.0002) and distant metastasis (p = 0.006).
Department of Radiation Therapy, Center for Adult Diseases, Osaka.
M
M
Chatani
Y
Y
Matayoshi
N
N
Masaki
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology / Q000401:mortality / Q000532:radiotherapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate; D016896:Treatment Outcome
D007770:L-Lactate Dehydrogenase