Acyclovir susceptibilities of herpes simplex virus strains isolated from solid organ transplant recipients after acyclovir or ganciclovir prophylaxis.
We determined the acyclovir (ACV) susceptibilities of herpes simplex virus (HSV) isolates (n = 18) recovered from solid organ transplant patients after antiviral prophylaxis with ACV or ganciclovir. All isolates tested were susceptible to ACV (50% inhibitory concentration, < 1 microM). A clinical review of patients with HSV disease showed that all improved with specific anti-HSV therapy, and no recurrences were reported.
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455.
G
G
Boivin
A
A
Erice
D D
DD
Crane
D L
DL
Dunn
H H
HH
Balfour
D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000517:prevention & control; D004352:Drug Resistance, Microbial; D015774:Ganciclovir / Q000627:therapeutic use*; D006561:Herpes Simplex / Q000517:prevention & control; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics; D014184:Transplantation, Homologous / Q000502:physiology*; D010948:Viral Plaque Assay
D015774:Ganciclovir; D000212:Acyclovir