Differanisole A, an inducer of the differentiation of Friend leukemic cells, induces stalk cell differentiation in Dictyostelium discoideum.
Differanisole A isolated from the conditioned medium of a soil microorganism, Chaetomium strain RB-001, is an inducer of the differentiation of the Friend leukemic cells (mouse leukemia cells). The chemical structure of this substance is very similar to that of stalk cell differentiation-inducing factor (DIF) isolated from the cellular slime mould, Dictyostelium discoideum. We examined the effects of differanisole A on Dictyostelium HM44 cells, a mutant strain which is defective in DIF production, and found this substance to be an inducer of stalk cell differentiation in D. discoideum.
Department of Botany, Faculty of Science, Kyoto University, Japan.
Y
Y
Kubohara
K
K
Okamoto
Y
Y
Tanaka
K
K
Asahi
A
A
Sakurai
N
N
Takahashi
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002723:Chlorobenzoates / Q000737:chemistry / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D004023:Dictyostelium / Q000166:cytology / Q000187:drug effects*; D006588:Hexanones / Q000737:chemistry / Q000494:pharmacology; D004915:Leukemia, Erythroblastic, Acute; D051379:Mice; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D002723:Chlorobenzoates; D006588:Hexanones; C053433:1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; C046689:differanisole A; D000242:Cyclic AMP