Hormonal and biochemical profiles of premenstrual syndrome. Treatment with essential fatty acids.
Women diagnosed as suffering from premenstrual syndrome and symptom free controls were compared on hormonal parameters, glucose tolerance, mineralocorticoids, cholesterols, triglycerides, apolipoprotein (a), magnesium and calcium in the follicular and luteal phases of the menstrual cycle. The effect of treatment with essential fatty acids on the biochemical variables was also evaluated in a randomized, double-blind crossover design. The results showed that the hormonal and biochemical profiles of women with PMS and symptom free controls were markedly similar, except for aldosterone which was lower in the follicular and luteal phases and cholesterol which was higher in the follicular phase in women with PMS. No effects of treatment with essential fatty acids were found for any of the biochemical variables studied.
Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
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Cerin
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Collins
B M
BM
Landgren
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Eneroth
D000328:Adult; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D004573:Electrolytes / Q000097:blood; D005228:Fatty Acids, Essential / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D005498:Follicular Phase; D005951:Glucose Tolerance Test; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008041:Linoleic Acids; D017270:Lipoprotein(a) / Q000097:blood / Q000187:drug effects; D008183:Luteal Phase; D008901:Mineralocorticoids / Q000097:blood; D031665:Oenothera biennis; D010938:Plant Oils; D011293:Premenstrual Syndrome / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood; D017965:gamma-Linolenic Acid
D004573:Electrolytes; D005228:Fatty Acids, Essential; D012739:Gonadal Steroid Hormones; D000960:Hypolipidemic Agents; D008041:Linoleic Acids; D017270:Lipoprotein(a); D008901:Mineralocorticoids; D010938:Plant Oils; D014280:Triglycerides; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D002784:Cholesterol