Synchronized inversion recovery-spin echo sequences for precise in vivo T1 measurement of human myocardium: a pilot study on 22 healthy subjects.
An ECG-triggered, two-sequence MRI technique is proposed for the precise measurement of proton T1 relaxation times of the human myocardium at a field strength of 0.5 T. The combination of an inversion recovery (IR) sequence and a spin echo (SE) sequence is not new. It is, however, rarely used in quantitative in vivo cardiac studies. Our approach employs a synchronization of the 90 degrees read pulse to the systolic period. In a study of 22 healthy volunteers, the globally measured T1 value was estimated to be 714 +/- 23 ms. Four of the volunteers also underwent additional imaging scans for the purposes of reproducibility assessment. The T1 precision was found to be 3.9 +/- 1.1% for the IR/SE combination and 16.9 +/- 5.3% for a combination of SE sequences. Total imaging time for the IR and SE sequences was 19.2 +/- 3.0 mins. The relative rapidity of this classic technique and the T1 precision obtained give this technique an obvious application in the discrimination of normal and diseased myocardium. In the same study, valuable supplementary tissue characterization is provided by T2, calculated from the SE sequence. T2 was evaluated to be 50 +/- 3 ms.
Walker
P M
PM
Laboratoire de Biophysique, Faculté de Médecine, Université de Nancy I, France.
Marie
P Y
PY
Mezeray
C
C
Bessieres
M
M
Escanyé
J M
JM
Karcher
G
G
Danchin
N
N
Mattei
S
S
Villemot
J P
JP
Bertrand
A
A
D000328:Adult; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects