Mucosal de novo cancer of the rectum following radiation therapy for uterine cancer.
A 54-year-old woman who underwent a hysterectomy and radiation therapy for carcinoma of the uterine cervix developed mucosal de novo cancer of the rectum 12 years later. The rectal lesion was elevated, measuring 0.8 x 0.7 x 0.3 cm, and its surface was relatively smooth. Microscopically, this tumor consisted of a well-differentiated tubular adenocarcinoma which had invaded the depth of the mucosa. Late radiation injuries were observed around the tumor. We diagnosed this lesion as a radiation-induced mucosal de novo adenocarcinoma of the rectum on the basis of the criteria of Black and Ackerman (Clin Radiol 16:278, 1965). This case underscores the need for careful long-term follow-up studies of the large intestines of patients who underwent therapeutic irradiation for uterine cancer.
Department of Pathology, Nagasaki University School of Medicine, Japan.
T
T
Matsuo
M
M
Ito
I
I
Sekine
M
M
Kishikawa
K
K
Taketomi
D000230:Adenocarcinoma / Q000209:etiology* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*