["Critical point" as a risk factor of central nervous system hemorrhagic complications in patients with blastic phase of chronic myelogenous leukemia].
Clinical and neuropathological investigations have been performed on 29 patients deceased due to blastic phase of chronic myelogenous leukemia. The authors tried to determine if the risk of death due to hemorrhagic complications in the central nervous system (CNS) increased in the period of blastic phase with simultaneous hyperleukocytosis above 100 G/l and thrombocytopenia below 25 G/l. The results have revealed that in the above mentioned period named "critical point" the probability of death due to hemorrhages is over 7 times as high as during hyperleukocytosis without thrombocytopenia and almost twice as high as during thrombocytopenia without hyperleukocytosis.
Kliniki Neurologii, Pomorskiej A.M., Szczecinie.
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P
Nowacki
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B
Zdziarska
D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors