Perfluorooctane sulfonic acid is a potent inducer of peroxisomal fatty acid beta-oxidation and other activities known to be affected by peroxisome proliferators in mouse liver.
Perfluorooctane sulfonic acid is almost as potent as perfluorooctanoic acid in causing increases in peroxisomal fatty acid beta-oxidation, peroxisomal catalase activity, omega-hydroxylation of lauric acid, cytosolic epoxide hydrolase activity and cytosolic DT-diaphorase activity. Octane sulfonic acid was ineffective at doses used for perfluorooctane sulfonic acid and perfluorooctanoic acid. The results support the theory of co-regulation of these parameters and peroxisome proliferation. The fact that perfluorooctane sulfonic acid causes peroxisome proliferation challenges the hypothesis that the first step in this process is formation of a thioester between the proliferator (the carboxylic group) and coenzyme A.
Department of Biochemistry, Wallenberg Laboratory, Stockholm University, Sweden.
A K
AK
Sohlenius
A M
AM
Eriksson
C
C
Högström
M
M
Kimland
J W
JW
DePierre
D000214:Acyl Coenzyme A / Q000378:metabolism; D000476:Alkanesulfonates / Q000494:pharmacology*; D017738:Alkanesulfonic Acids; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003600:Cytosol / Q000201:enzymology; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism*; D005466:Fluorocarbons / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008830:Microbodies / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D015262:Xenobiotics / Q000494:pharmacology
D000214:Acyl Coenzyme A; D000476:Alkanesulfonates; D017738:Alkanesulfonic Acids; D005227:Fatty Acids; D005466:Fluorocarbons; D000960:Hypolipidemic Agents; D015262:Xenobiotics; C076994:perfluorooctane sulfonic acid