Prevention of AIDS in HIV-infected people by means of T cells stimulated with microbial superantigens?
It has been shown that neuroleukin, a secretary product of T cells, is partly homologous to HIV gp 120 envelope protein. Since HIV naive T cells sometimes induce the production of antibodies against HIV coat proteins in a new host, it is suggested that the development of AIDS in HIV-infected people could be prevented by means of T cells stimulated with superantigens of either bacterial or viral origin.
Kellokoski Hospital, Finland.
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Elomaa
D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D000942:Antigens, Bacterial; D000956:Antigens, Viral; D005956:Glucose-6-Phosphate Isomerase / Q000276:immunology; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D000956:Antigens, Viral; D005956:Glucose-6-Phosphate Isomerase