Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle.
Eighteen of 91 seven- to nine-month-old Belgian white and blue double-muscled male fattening cattle developed typical signs of shipping fever. They were all injected intramuscularly once a day for three days with 5 mg/kg of enrofloxacin, and in addition nine selected at random were injected intramuscularly five times at 12 hour intervals with 0.1 mg/kg of metrenperone, a 5-hydroxytryptamine blocker, the other nine receiving a placebo. During the outbreak of shipping fever metrenperone showed effective antipyretic properties, and all the calves treated with it made a complete recovery. Moreover, during the 360 day fattening period following the outbreak, the cattle treated with metrenperone gained on average 45.4 kg more weight than the control cattle.
Genicot
B
B
Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Belgium.
Mouligneau
F
F
Rollin
F
F
Lindsey
J K
JK
Close
R
R
Lekeux
P
P
D000818:Animals; D000890:Anti-Infective Agents; D002417:Cattle; D004196:Disease Outbreaks / Q000662:veterinary*; D004359:Drug Therapy, Combination; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D012766:Pasteurellosis, Pneumonic / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015363:Quinolones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012119:Respiration; D012129:Respiratory Function Tests / Q000662:veterinary; D015430:Weight Gain
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010880:Piperidines; D015363:Quinolones; D000077422:Enrofloxacin; C046881:metrenperone