Atopic dermatitis--messengers, second messengers and cytokines.
Atopic dermatitis (AD) shows many complex and interacting abnormalities of pharmacology, immunology and cellular control. Recent research in atopy has concentrated on abnormalities of cytokine production by T-helper cells. It is possible that cytokine imbalance causes many of the pharmacological and immunological changes seen in the disease. However, studies of second messenger control of cytokine release show that different second messenger signals may relate to the release and activation of particular cytokines. This review summarizes these findings and discusses how the second messenger defects reported in AD may relate to the abnormal cytokine profiles and the pharmacological abnormalities seen in the condition.
St Helier Hospital, Carshalton, UK.
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Holden
D000242:Cyclic AMP / Q000378:metabolism; D016207:Cytokines / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016207:Cytokines; D010716:Phosphatidylinositols; D000242:Cyclic AMP