Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse.
We studied the effects of CGP 35348, a centrally active blocker of GABAB receptors, on scopolamine-induced amnesia for a passive avoidance response in the mouse. Both pre-training or post-training intraperitoneal administration of the GABAB antagonist (75, 150 and 300 mg/kg i.p.) significantly reduces the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results are in agreement with previous observations indicating a role for the GABAB receptors in the modulation of memory function, and suggest a possible role of GABAB receptor antagonists as nootropic drugs.
Department of Pharmacology, University of Milano, Italy.
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Bianchi
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Panerai
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D058787:GABA-A Receptor Antagonists; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D058787:GABA-A Receptor Antagonists; D009943:Organophosphorus Compounds; C066430:CGP 35348; D012601:Scopolamine