Expression of alpha isoforms of the Na,K-ATPase in human heart.
We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase alpha-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5%, alpha 1, 15% alpha 2 and 22.5% alpha 3 on average. There was an increase in expression of the alpha 3 isoform in samples from failing hearts, but expression of all three isoforms decreased in pressure-overloaded right ventricle (RV).
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
R
R
Zahler
M
M
Gilmore-Hebert
J C
JC
Baldwin
K
K
Franco
E J
EJ
Benz
D000818:Animals; D001921:Brain / Q000201:enzymology; D009202:Cardiomyopathies / Q000201:enzymology; D004285:Dogs; D015870:Gene Expression; D006352:Heart Ventricles; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D007668:Kidney / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D012333:RNA, Messenger / Q000032:analysis; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis*
D007527:Isoenzymes; D012333:RNA, Messenger; D000254:Sodium-Potassium-Exchanging ATPase