[Hepatocyte polyploidization in chronic liver diseases in man].
Levels of hepatocyte ploidy were investigated in patients with chronic viral hepatitis, alcohol hepatitis, and liver cirrhosis. It was shown that in spite of some decrease in the share of mononucleate diploid hepatocytes these cells equally make the main part of hepatocyte population (about 80% on the average) both during chronic liver diseases and in the norm. In chronic hepatitis and cirrhosis processes of polyploidization in the human liver, unlike those in livers of laboratory animals (rats and mice), are accomplished with much lower rates and characterized by accumulation of binucleate diploid cells. These processes differ from those occurring under ageing. Reparative regeneration of human liver under chronic hepatitis and cirrhosis is accomplished on the whole by proliferation of mononucleate diploid hepatocytes but processes of polyploidization in the liver of some patients can play a significant role in reparative liver growth.
Kudriavtsev
B N
BN
Kudriavtseva
M V
MV
Sakuta
G A
GA
Skorina
A D
AD
Shteĭn
G I
GI
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000648:ultrastructure; D002908:Chronic Disease; D004247:DNA / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000648:ultrastructure*; D008107:Liver Diseases / Q000473:pathology*; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D011123:Polyploidy
D004247:DNA