[A method for the primary selection of immunomodulators by the level of 5'-nucleotidase activity in the macrophages of peritoneal exudate].
A method of primary selection of immunomodulators based on measuring of ecto 5'-nucleotidase activity level of macrophages of peritoneal exudate was developed. Immunostimulators were found to decrease the activity level, while immunosuppressors increased the activity. The preparations having no immunomodulatory effect do not change the activity of this enzyme.
G B
GB
Kirillicheva
M S
MS
Solov'eva
I G
IG
Baturina
M A
MA
Tumanian
D015720:5'-Nucleotidase / Q000187:drug effects*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001202:Ascitic Fluid / Q000201:enzymology*; D001424:Bacterial Infections / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D012044:Regression Analysis
D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D015720:5'-Nucleotidase