Myeloperoxidase deficiency in a patient with rheumatoid arthritis: oxygenation and radical activity by phagocytic cells.
Complete functional deficiency of the phagocytic cell enzyme, myeloperoxidase, is described in a patient with rheumatoid arthritis. Measurement of oxygenation and free radical activity by blood monocytes and polymorphonuclear leucocytes shows gross reduction in myeloperoxidase-dependent chemiluminescence. Implications of these data for theories linking reactive oxygen species to inflammatory tissue damage in rheumatoid arthritis are discussed.
Department of Medicine (Rheumatology), School of Clinical Medicine, Queen's University, Belfast.
A L
AL
Bell
G M
GM
Markey
H D
HD
Alexander
T C
TC
Morris
S A
SA
McMillan
J A
JA
McNally
D000328:Adult; D000911:Antibodies, Monoclonal; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D004789:Enzyme Activation; D005260:Female; D005609:Free Radicals; D006801:Humans; D008163:Luminescent Measurements; D009000:Monocytes / Q000378:metabolism / Q000502:physiology; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000172:deficiency*; D010586:Phagocytes / Q000378:metabolism / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism
D000911:Antibodies, Monoclonal; D005609:Free Radicals; D013481:Superoxides; D009195:Peroxidase