Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas.
It has been realized for some time that the loss of epithelial differentiation in carcinomas, which is accompanied by higher mobility and invasiveness of the tumor cells, is a consequence of reduced intercellular adhesion. A variety of recent reports have indicated that the primary cause for the 'scattering' of the cells in invasive carcinomas is a loss of the integrity of intercellular adherens junctions often involving loss of a functional cell-cell adhesion molecule E-cadherin. In the present review, permanent and transient molecular mechanisms are discussed which lead to the impairment of junctional integrity of cells and thus the progression of carcinomas toward a more metastatic state.
Institute of Cell Biology (Tumor Research), University of Essen Medical School, Germany.
W
W
Birchmeier
K M
KM
Weidner
J
J
Hülsken
J
J
Behrens
D000818:Animals; D001483:Base Sequence; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002645:Chickens; D004273:DNA, Neoplasm / Q000737:chemistry; D015972:Gene Expression Regulation, Neoplastic; D017228:Hepatocyte Growth Factor / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D011401:Promoter Regions, Genetic; D051381:Rats; D014407:Tumor Cells, Cultured
D015820:Cadherins; D004273:DNA, Neoplasm; D017228:Hepatocyte Growth Factor