Lineage-restricted chromosome translocation in a benign fibrous tumor of the breast.
We describe a clonal chromosome rearrangement, t(4;14)(q24-25;q24.3), in a benign fibrous tumor of the breast. This is the first reported cytogenetic analysis of a fibrous tumor of the breast and the first evidence for clonality in these lesions. A combined immunohistochemical/cytogenetic study demonstrated that cells with the clonal translocation were mesenchymal. Epithelial cells, in contrast, had normal chromosomes.
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
F
F
Belda
S C
SC
Lester
J L
JL
Pinkus
G S
GS
Pinkus
J A
JA
Fletcher
D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D003582:Cytogenetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D014178:Translocation, Genetic