Effects of opiates on neuronal development in the rat cerebral cortex.
Quantitative morphological characteristics of cells in the primary somatosensory cortex of 6-day-old rats were examined following continuous maternal administration of morphine (10 mg/kg/day), naltrexone (10 mg/kg/day), or saline vehicle from gestation day 12. Naltrexone reduced neuronal packing density and significantly increased cortical thickness but had not effect on neuronal number, while morphine reduced neuronal packing density and the number of neurons without affecting cortical thickness. These results suggest that blockade of endogenous opioid function during development enhances neuronal maturation in this brain region, while perinatal morphine administration might act to restrict cortical cell proliferation and maturation. Thus, the effect of ontogenetic activation of opioid receptors by endogenous opioid compounds could be similar to but less severe than the effect of exogenous opiate exposure on cortical cell development.
Department of Anatomy & Reproductive Biology, University of Hawaii School of Medicine, Honolulu 96822.
J V
JV
Seatriz
R P
RP
Hammer
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development*; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists; D009294:Narcotics / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000187:drug effects / Q000254:growth & development
D009292:Narcotic Antagonists; D009294:Narcotics; D009271:Naltrexone; D009020:Morphine