HIV-1-related neurological disease.
Infection due to human immunodeficiency virus type 1 (HIV-1) frequently leads to neurological complications that may involve each part of the neuraxis. A brief discussion is presented of the nature of involvement, appropriate treatment modalities, and the diagnostic approach to such problems. Emphasis will be placed on AIDS dementia complex (ADC). A summary of the current understanding of the pathogenesis of ADC will be presented and used as a platform for discussion of future therapeutic interventions.
Brew
B J
BJ
National Centre in HIV Epidemiology and Clinical Research, St. Vincent's Medical Centre, Sydney, Australia.
D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000188:drug therapy / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology