[Expression of human papillomavirus (HPV) gene in HPV-positive laryngeal tumors and activity of the HPV long control region in cultured normal laryngeal epithelial cells].
Expression of the human papillomavirus (HPV) gene was examined in HPV-positive laryngeal tumors. Moreover, the activity of the HPV long control region (LCR) was tested in cultured laryngeal epithelial cells. HPV-11 early genes were heterogeneously expressed in adult laryngeal papillomas. We found one laryngeal carcinoma case in whom the HPV-16 transforming genes, E6 and E7, were expressed. Both HPV-11 and -16 LCRs were active in cultured laryngeal epithelial cells from vocal cords. These results suggest that laryngeal epithelial and tumor cells are target cells for HPV gene expression.
Department of Otorhinolaryngology, St. Marianna University School of Medicine, Kawasaki.
K
K
Tsutsumi
T
T
Hoshikawa
T
T
Suzuki
I
I
Takeyama
D000328:Adult; D000368:Aged; D015344:DNA Probes, HPV; D004848:Epithelium / Q000382:microbiology; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000382:microbiology; D007830:Larynx / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D027383:Papillomaviridae / Q000235:genetics*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D015344:DNA Probes, HPV