Cytogenetic and molecular studies in the Prader-Willi and Angelman syndromes: an overview.
The majority of patients with Angelman syndrome and Prader-Willi syndrome have a cytogenetic and molecular deletion of chromosome 15q11q13 with the primary difference being in the parental origin of deletion. Our current understanding of the cytogenetics and molecular genetics of these 2 clinically distinct syndromes will be discussed in this review.
Knoll
J H
JH
Genetics Division, Children's Hospital, Boston, Massachusetts.
Wagstaff
J
J
Lalande
M
M
D017204:Angelman Syndrome / Q000235:genetics*; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D005260:Female; D006801:Humans; D008297:Male; D011218:Prader-Willi Syndrome / Q000235:genetics*; D011963:Receptors, GABA-A / Q000235:genetics
D011963:Receptors, GABA-A