Paniceins and related sesquiterpenoids from the Mediterranean sponge Reniera fulva.
Two novel sesquiterpenes, fulvanin 1 [1] and fulvanin 2 [2], have been isolated from the Mediterranean sponge Reniera fulva. Compound 2 is a sesquiterpenoid linked to a hydroquinone. Also found in Reniera fulva are four known paniceins, a group of aromatic sesquiterpenoids linked to a quinol, isolated previously from Halichondria panicea. The total assignments of 13C-nmr spectra of paniceins have been made with the aid of 2D1H-13C correlation techniques, confirming their structures. The paniceins were tested in the in vitro disease-oriented primary antitumor screen at NCI, Bethesda. Paniceins C and B3 showed cytotoxicity against NCI-H522 non-small lung cancer cells and CCRF-CEM leukemia cells, while panicein A hydroquinone revealed more selective cytotoxicity against the latter ones.
Casapullo
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A
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
Minale
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L
Zollo
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F
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes