Acute hypertensive response to saline induced by vanadate, an insulinomimetic agent.
OBJECTIVE
To investigate whether the reported insulin-like properties of vanadate may have hypertensinogenic actions in Sabra rats.


METHODS
Comparison of [3H]-deoxyglucose muscle uptake as well as blood pressure and its response to acute volume expansion and pressors infusions in 16 vanadate-treated (VT) and 12 control rats.


METHODS
Rats drank either tap water or 0.2 g/l vanadate for 4 weeks. A trace amount of [3H]-deoxyglucose was administered intravenously to evaluate its plasma half-life and tissue uptake. Intra-arterial blood pressure was recorded in response to acute intravenous saline (4 ml/100 g body weight) and to incremental bolus injections of noradrenaline and angiotensin II (Ang II).


RESULTS
Skeletal muscle uptake of [3H]-deoxyglucose was significantly higher in VT than in control rats. There was no difference between the blood pressure of VT or control rats; however, 2 h after saline loading the mean intra-arterial blood pressure was significantly higher in VT than in control rats. The Ang II-induced blood pressure rise was also significantly higher in VT rats.


CONCLUSIONS
The insulin-like activity of vanadate may be associated with salt-sensitive hypertension.
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
M
M
Bursztyn
J
J
Mekler
D000818:Animals; D003847:Deoxyglucose / Q000493:pharmacokinetics; D006973:Hypertension / Q000139:chemically induced*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000378:metabolism; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D014638:Vanadates / Q000494:pharmacology*
D007328:Insulin; D014638:Vanadates; D012965:Sodium Chloride; D003847:Deoxyglucose