NC-1300, a proton-pump inhibitor, requires gastric acid to exert cytoprotection in rat gastric mucosa.
Effect of gastric acid suppression on the cytoprotective effect of a single dose of NC-1300 given intragastrically was studied. NC-1300 given intragastrically prevented gastric mucosal damage caused by absolute ethanol in rats in a dose-related manner, while the drug given subcutaneously did not. Pretreatment with NC-1300 given subcutaneously to suppress acid secretion abolished the protective effect of NC-1300 given intragastrically, but not in the presence of 0.1 N HCl. Repeated intragastric administration of NC-1300 for 7 days failed to prevent the ethanol damage. These results suggest that NC-1300 requires gastric acid to exert a protective effect against ethanol in rat gastric mucosa.
Arakawa
T
T
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Fukuda
T
T
Higuchi
K
K
Koike
K
K
Satoh
H
H
Kobayashi
K
K
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism / Q000502:physiology*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives; D017494:Proton Pumps / Q000187:drug effects; D011708:Pylorus / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D017494:Proton Pumps; C048733:2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole; D000431:Ethanol; D000254:Sodium-Potassium-Exchanging ATPase; D009853:Omeprazole