Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A.
Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of delaminomycin A was determined to be 3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]- 1,6,8- trimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthyl]carbonyl]-5- hydroxypyrrolidine-2,4-dione by analyses of spectral properties and chemical studies.
Ueno
M
M
Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
Someno
T
T
Sawa
R
R
Iinuma
H
H
Naganawa
H
H
Ishizuka
M
M
Takeuchi
T
T
D000276:Adjuvants, Immunologic / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D011760:Pyrrolidinones / Q000737:chemistry* / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D013302:Streptomyces / Q000737:chemistry*; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D011760:Pyrrolidinones; D011956:Receptors, Cell Surface; D013764:Tetrahydronaphthalenes; C052131:extracellular matrix receptor; C082438:delaminomycin A