Liposomal amphotericin B bases of therapeutic index increase.
Liposomes represent for amphotericin B (AmB) a promising delivery system that may reduce the important toxicity of the drug. Liposomal AmB has a higher therapeutic index than AmB alone and allows to use larger doses. The mechanism of reduced toxicity may be related to a better targeting ability, a protective effect, and a selective transfer of liposomes. Anyway the liposomes intercalated AmB tends to be uptaken by organs that belong to the reticuloendothelial system, where fungi, the target cells, are localized.
Legrand
P
P
Laboratoire de Physique et Chimie Biomoléculaires, Université Pierre et Marie Curie, Paris.
Vertut-Doï
A
A
Bolard
J
J
D000666:Amphotericin B / Q000008:administration & dosage* / Q000633:toxicity; D000818:Animals; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes
D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B