The NMDA receptor antagonist MK-801 protects against the development of morphine tolerance after intrathecal administration.
Kest
B
B
Department of Psychology, University of California, Los Angeles 90024.
Mogil
J S
JS
Shamgar
B E
BE
Kao
B
B
Liebeskind
J C
JC
Marek
P
P
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004361:Drug Tolerance; D007278:Injections, Spinal; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D009020:Morphine