Possibility of targeting treatment for ischemic heart disease with liposome (I).
This paper reports the basic research on the possibility of using targeting treatment for ischemic heart disease with liposome as drug carrier. Studies have been performed on isolated rat cardiomyocytes, or isolated perfused rat and rabbit hearts. Results show that cardiomyocytes may interact with liposome through fusion, endocytosis, adsorption and molecular exchange of phospholipid. Forms of cellular uptake of liposome depend chiefly on the physicochemical properties of liposomes. Anoxia changes the pattern of liposome uptake by cardiomyocytes and increases uptake of liposomes. Uptake of liposomes, especially of positively charged liposomes by ischemic myocardium is significantly increased. The quantity of increase of liposome uptake is in the following order: ischemia-reperfusion area > peripheral area of the infarct > non-ischemic area > infarcted area. The above results indicate that liposome as drug carrier might promote the delivery of drug into ischemic myocardium and cardiomyocytes.
Tang
C S
CS
Department of Pathophysiology, Beijing Medical University, PRC.
Su
J Y
JY
Li
Z P
ZP
Zhang
L Z
LZ
Yang
J
J
Qi
M
M
Liu
F A
FA
Tang
J
J
D000818:Animals; D015687:Cell Hypoxia; D004337:Drug Carriers; D004705:Endocytosis; D066298:In Vitro Techniques; D008081:Liposomes / Q000378:metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D004337:Drug Carriers; D008081:Liposomes