A new receptor protein kinase from chick embryo related to type II receptor for TGF-beta.
We have isolated cDNA encoding a new member of protein kinase family from chicken embryo cDNA library. The deduced amino acid sequence comprises a cysteine-rich extracellular domain, a single hydrophobic transmembrane domain, and a cytoplasmic serine/threonine kinase domain. Two short inserts are contained in the kinase domain. The primary structure shows that it belongs to the receptor-type serine/threonine kinase subfamily and is most similar to Daf-1. Conserved cysteine residues in the ectodomain suggest the protein as a receptor for a peptide growth factor of TGF-beta family.
Department of Pharmacology, Kawasaki Medical School, Kurashiki, Japan.
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Sumitomo
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Saito
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Nohno
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002642:Chick Embryo; D018076:DNA, Complementary / Q000302:isolation & purification; D008969:Molecular Sequence Data; D010802:Phylogeny; D017346:Protein Serine-Threonine Kinases; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D000077293:Receptor, Transforming Growth Factor-beta Type I; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D018125:Receptors, Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta; D020794:Receptor Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I