The effect of (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine (HPMPC) on bovine herpesvirus-1 (BHV-1) infection and reactivation in cattle.
A reproducible pattern of respiratory disease was produced in calves inoculated intranasally with a pathogenic strain of bovine herpesvirus-1 (BHV-1). A latent infection was established which could be reactivated by means of corticosteroid administration. Groups of calves were given a single dose of 20 mg/kg of (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine (HPMPC) either the day before or the day following virus inoculation. The drug markedly reduced clinical signs and virus replication; the therapeutic dose appeared to be more effective than the dose given one day before virus inoculation. The establishment of latency was not prevented and a single dose of HPMPC, the day before a course of dexamethasone (6 weeks after the acute infection), did not prevent virus shedding.
Department of Clinical Veterinary Medicine, Cambridge, UK.
S E
SE
Gilliam
H J
HJ
Field
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001831:Body Temperature; D002417:Cattle; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D003907:Dexamethasone / Q000494:pharmacology; D004361:Drug Tolerance; D005069:Evaluation Studies as Topic; D005123:Eye / Q000382:microbiology; D007242:Herpesvirus 1, Bovine / Q000187:drug effects; D007241:Infectious Bovine Rhinotracheitis / Q000188:drug therapy*; D008297:Male; D009296:Nasal Cavity / Q000382:microbiology; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use* / Q000633:toxicity; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003907:Dexamethasone; D003596:Cytosine; D000077404:Cidofovir