Phagocyte recognition of cells undergoing apoptosis.
A key feature of apoptosis is that cells undergoing this programmed form of death are recognized by phagocytes and ingested while still intact, protecting tissues from the potentially harmful consequences of exposure to the contents of the dying cells. This article reviews recent data which indicate that phagocyte recognition of apoptotic cells as 'senescent-self' involves at least three classes of receptors on the phagocyte surface, while apoptotic cells may display their 'edible' status in a number of different ways.
Dept of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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J
Savill
V
V
Fadok
P
P
Henson
C
C
Haslett
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development; D002450:Cell Communication; D006801:Humans; D037102:Lectins / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000502:physiology; D009842:Oligopeptides / Q000502:physiology; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis; D010718:Phosphatidylserines / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology
D037102:Lectins; D009842:Oligopeptides; D010718:Phosphatidylserines; D011956:Receptors, Cell Surface; C047981:arginyl-glycyl-aspartic acid