The oxytocin secretory response during suckling in the hypoosmolar lactating rat.
Secretion of oxytocin into the peripheral circulation of rats is stimulated by suckling and inhibited by hypoosmolality. We compared the oxytocin secretory response to suckling in 1 week post partum lactating rats rendered hyponatremic for 48 h to matched lactating normonatremic cohorts. Pituitary content of oxytocin and peripheral oxytocin secretory responses to suckling were equivalent in normonatremic and hyponatremic animals. We conclude that induction of sustained hyponatremia for 48 h does not inhibit suckling-induced oxytocin release in lactating rats.
Department of Medicine, University of Pittsburgh School of Medicine, PA 15261.
P L
PL
Bononi
J E
JE
Janosky
J A
JA
Amico
D000818:Animals; D000833:Animals, Suckling; D003894:Deamino Arginine Vasopressin; D005260:Female; D007010:Hyponatremia / Q000139:chemically induced / Q000503:physiopathology*; D007774:Lactation / Q000502:physiology*; D009994:Osmolar Concentration; D010121:Oxytocin / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values
D010121:Oxytocin; D003894:Deamino Arginine Vasopressin