[The "anti-Ki" syndrome: major clinical features].
OBJECTIVE
To describe the major clinical features of patients with high titers of anti-Ki antibodies.


RESULTS
Four of 172 patients with connective tissue diseases showed high titers (> 1/256) of anti-Ki antibodies. In these four patients, (1) the common clinical findings were alopecia, disabling chronic fatigue, muscle weakness, tenosynovitis, dry mouth, and abnormal glucose tolerance test; (2) anti-Ki antibodies were positive not only in patients with sicca lupus, but also in those with nonsicca lupus. In this case, anti-insulin receptor antibody was positive and there was a regulatory insufficiency of the pituitary. (3) Symptoms of anti-Ki antibodies share many clinical and laboratory features of chronic fatigue syndrome and fibromyalgia, that is, they may share either a common etiologic agents or a common pathogenetic pathway or both.


CONCLUSIONS
"Anti-Ki antibody" syndrome may be a subset of sicca lupus.
Matsunaga
K
K
1st Department of Internal Medicine, Urafune Hospital Yokohama City University School of Medicine.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001483:Base Sequence; D015673:Fatigue Syndrome, Chronic / Q000209:etiology; D005260:Female; D005356:Fibromyalgia / Q000209:etiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008875:Middle Aged; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000276:immunology*
D001323:Autoantibodies; D009687:Nuclear Proteins