[Behavior of post-occlusion systolic blood pressure after long duration blockade. Effect of induced hypertension].
A suprasystolic blockade (300 mm Hg) was applied for 50 to 60 min to the thigh of the affected leg with a blood pressure cuff in 13 patients with occlusions of the femoral artery. Afterwards, the pre-postocclusive systolic pressure difference was clearly less in most patients than before the compression manoeuvre. This reduction of the systolic pressure gradient, which was greatest in the first hour and slowly decreased in subsequent days, is likely to be based on a dilatation of the collateral arteries. The reaction was especially pronounced in patients with isolated occlusion of the femoral artery. Since the entire collateral circulation is largely in the region of the cuff compression in these cases, the collateral dilatation might arise from the powerful and long lasting pressure. In 9 patients it was investigated whether an increase of systemic blood pressure induced by hypertension can be transduced more effectively to the postocclusive arterial system when the collateral arteries are "paralyzed". The heterogeneous results show that such an effect can evidently only be expected when the collateral circulation is restricted to the thigh. However, such conditions are probably not usual in poorly compensated stage IV following Fontaine, in which a temporary peripheral increase of blood pressure is likely to be reasonable for therapy.
Klinik für Gefässerkrankungen der LVA Rheinprovinz.
D
D
Neuerburg-Heusler
W
W
Schoop
D000328:Adult; D000802:Angiotensin Amide / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007511:Ischemia / Q000503:physiopathology / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D015424:Reperfusion; D013599:Systole / Q000187:drug effects / Q000502:physiology*; D014111:Tourniquets
D000802:Angiotensin Amide