Resistance and susceptibility of bovine cells expressing herpesviral glycoprotein D homologs to herpesviral infections.
Bovine cell lines individually expressing two related herpesviral proteins, pseudorabies virus glycoprotein 50 and herpes simplex virus type 1 glycoprotein D, were examined for their susceptibility/resistance to infection with several alphaherpesviruses. Cell lines expressing gp50 or gD-1 resisted plaque formation by the homologous virus more than by the heterologous viruses. Bovine cells expressing bovine herpesvirus 1 glycoprotein IV (gIV) were susceptible to infection with three other bovine herpesviruses: bovine herpesvirus 2, bovine herpesvirus 4 (BHV-4) and alcelaphine herpesvirus 1. One line of gIV-expressing cells was resistant to the formation of BHV-4 plaques, suggesting that a cell-associated factor may be responsible for inhibiting cell-to-cell spread.
Department of Veterinary Science, University of Wisconsin-Madison 53706.
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Lohff
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Letchworth
D000818:Animals; D002417:Cattle; D002460:Cell Line; D005347:Fibroblasts / Q000382:microbiology*; D006564:Herpesviridae / Q000235:genetics / Q000254:growth & development*; D001911:Herpesvirus 2, Bovine / Q000254:growth & development; D014759:Viral Envelope Proteins / Q000096:biosynthesis* / Q000235:genetics; D014762:Viral Interference; D010948:Viral Plaque Assay
D014759:Viral Envelope Proteins; C039447:glycoprotein D, Human herpesvirus 1; C042966:pseudorabies virus glycoproteins