Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis.
A 4-year-old female with nephrotic syndrome secondary to focal segmental glomerulosclerosis (FSGS) was treated with pulse methylprednisolone and chlorambucil therapy. She subsequently developed fatal Pneumocystis carinii pneumonia (PCP). This is the first report of a pediatric patient whose treatment for FSGS resulted in PCP, raising the issue of PCP prophylaxis for these patients.
Murphy
J L
JL
Department of Pediatrics, University of California, Davis, Sacramento 95817.
Kano
H L
HL
Chenaille
P J
PJ
Makker
S P
SP
D002675:Child, Preschool; D002699:Chlorambucil / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000209:etiology*; D011020:Pneumonia, Pneumocystis / Q000209:etiology*
D002699:Chlorambucil; D008775:Methylprednisolone