Increased incidence of anti-dsDNA autoantibody concentration in sera of workers occupationally exposed to diisocyanates.
Sera of 87 industrial workers with a history of occupational exposition to various diisocyanates, toluene diisocyanate, hexamethylene diisocyanate and methylene-diphenyl diisocyanate were analyzed for antibodies to isocyanate-conjugated human serum albumin and for anti-dsDNA autoantibodies. Ten workers (approx. 11%) were shown to have elevated anti-dsDNA autoantibody concentrations and 13 revealed antibodies to isocyanate-modified human serum albumin. The overlap of both tests being positive was calculated at about 40%. It would seem, therefore, that routine estimation of anti-dsDNA autoantibodies could provide additional useful information for the clinical diagnosis of occupational health impairment due to isocyanate exposure.
Czuppon
A B
AB
Department of Allergology, Ruhr-University of Bochum, Germany.
Marczynski
B
B
Scheer
E
E
Hartmann
R
R
Baur
X
X
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D003485:Cyanates / Q000276:immunology / Q000633:toxicity*; D004247:DNA / Q000276:immunology*; D006801:Humans; D017953:Isocyanates; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D014051:Toluene 2,4-Diisocyanate / Q000633:toxicity; D001559:Benzhydryl Compounds
D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D003485:Cyanates; D004247:DNA; D017953:Isocyanates; D014051:Toluene 2,4-Diisocyanate; C026408:anti-IgE antibodies; C015262:1,6-hexamethylene diisocyanate; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds