Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers.
Proton-decoupled, 31P three-dimensional (3-D) chemical shift imaging (CSI) spectra have been acquired from the entire human brain using a new dual tuned resonator. The resonator operates in quadrature mode to provide improved sensitivity, excellent B1 homogeneity and reduced power deposition at both frequencies. Proton-decoupled and fully NOE enhanced, 31P spectra were acquired from normal volunteers using Waltz-4 proton decoupling with continuous wave bi-level excitation applied through a second radio frequency channel. Well resolved peaks in the phosphomonoester (PME) and phosphodiester regions were obtained from nonlocalized FIDs and spectra localized with 3-D CSI without processing for resolution enhancement. pH measurements made over large regions of the brain using the P(i) resonance show no significant variations (6.9 +/- 0.02) for a single individual. The improved spectral resolution and sensitivity of the PME resonances results in more well defined metabolite images of the PME peak region.
Department of NMR, Fox Chase Cancer Center, Philadelphia, PA 19111.
J
J
Murphy-Boesch
R
R
Stoyanova
R
R
Srinivasan
T
T
Willard
D
D
Vigneron
S
S
Nelson
J S
JS
Taylor
T R
TR
Brown
D001921:Brain / Q000033:anatomy & histology*; D001923:Brain Chemistry; D005997:Glycerylphosphorylcholine / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010710:Phosphates / Q000032:analysis; D010714:Phosphatidylethanolamines / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus; D011522:Protons
D010710:Phosphates; D010714:Phosphatidylethanolamines; D011522:Protons; D010725:Phosphocreatine; C002449:glycerophosphoethanolamine; D010758:Phosphorus; D005997:Glycerylphosphorylcholine