The peculiar journey of a selfish chromosome: mouse t haplotypes and meiotic drive.
Mouse t haplotypes are descendents of a variant form of chromosome 17 that evolved the ability to propagate itself at the expense of the wild-type homolog from heterozygous +/t males. Although once enigmatic, these widespread selfish chromosomes have revealed many of their secrets in response to a combined assault with molecular, genetic and phylogenetic techniques. This review summarizes the current understanding of t haplotypes and their raison d'être.
Department of Molecular Biology, Princeton University, NJ 08544-1014.
L M
LM
Silver
D000818:Animals; D002874:Chromosome Mapping; D005804:Genes, Lethal; D006239:Haplotypes; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D008540:Meiosis; D051379:Mice / Q000235:genetics*; D009154:Mutation; D010802:Phylogeny