Glomerulocystic disease: unilateral involvement of a horseshoe kidney and in trisomy 18.
Two occurrences of glomerulocystic kidney disease (GCD) in children younger than 1 year are described. One child was 3 months old with trisomy 18; the other child was 6 months old with GCD localized to one side of a horseshoe kidney. Lectin and immunohistochemical studies in tissue from the second child suggested that the entire nephron may be affected in GCD. There may also be overlap of morphological features between GCD and early stages of autosomal dominant polycystic kidneys.
New Orleans Children's Hospital, Louisiana State University Medical Center.
R D
RD
Craver
J
J
Ortenberg
R
R
Baliga
D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007223:Infant; D007668:Kidney / Q000002:abnormalities*; D052177:Kidney Diseases, Cystic / Q000150:complications / Q000235:genetics* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D014314:Trisomy