Ditiocarb: decomposition in aqueous solution and effect of the volatile product on its pharmacological use.
The kinetic profile for the decomposition of ditiocarb sodium salt in aqueous solution was achieved with UV-visible absorption spectrometry. The kinetic profile indicates that the decomposition reaction is hydrogen ion-catalyzed over the entire 4-10 pH range and enables the determination of the value of the acid-base equilibrium constant (Ka = 4.0.10(-4) at 5 degrees C). Decomposition of ditiocarb produces volatile carbon disulfide, exclusive of hydrogen sulfide, as shown with electrochemical methods. This feature is of interest from a toxicological point of view.
Martens
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T
Laboratoire de Chimie Analytique, URA C.N.R.S., Faculté de Pharmacie, Paris, France.
Langevin-Bermond
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D
Fleury
M B
MB
D004050:Ditiocarb / Q000737:chemistry* / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D012996:Solutions; D014835:Volatilization
D012996:Solutions; D004050:Ditiocarb