Deposition of ciprofloxacin, prednisolone phosphate, and prednisolone acetate in SeeQuence disposable contact lenses.
We noted opaque deposits in SeeQuence disposable contact lenses in three patients with persistent epithelial defects who were being treated with topical ciprofloxacin and prednisolone acetate. In each patient, the contact lenses with deposits were removed and replaced. High performance liquid chromatography analysis revealed the deposits to be precipitates of ciprofloxacin and prednisolone acetate. We incubated new SeeQuence disposable contact lenses in ciprofloxacin, prednisolone phosphate, and prednisolone acetate alone and in combination. Precipitates did form when ciprofloxacin was combined with either prednisolone acetate or prednisolone phosphate. We recommend removal and replacement of contact lenses should these deposits develop to prevent the possibility of corneal toxicity.
West Virginia University, Department of Ophthalmology, Morgantown 26506-9193.
M S
MS
Macsai
A K
AK
Goel
M M
MM
Michael
G M
GM
Wall
K D
KD
Sternitzke
R L
RL
Abshire
D000368:Aged; D002939:Ciprofloxacin / Q000009:adverse effects*; D003263:Contact Lenses, Hydrophilic; D003316:Corneal Diseases / Q000188:drug therapy; D003460:Crystallization; D004209:Disposable Equipment; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011239:Prednisolone / Q000009:adverse effects / Q000031:analogs & derivatives*
D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; C009022:prednisolone phosphate; C009935:prednisolone acetate; D011239:Prednisolone