Changes in complement and immunoglobulin G receptor expression on neutrophils associated with Porphyromonas gingivalis-induced inhibition of phagocytosis.
We examined the phagocytic capacity and receptor expression on neutrophils stimulated with Porphyromonas gingivalis soluble products. Stimulated neutrophils had decreased phagocytic capacities and altered expression of CR1, CR3, Fc gamma RII, and Fc gamma RIII. For cases in which TLCK (N-alpha-p-tosyl-L-lysine chloromethyl ketone) neutralized the effects of the stimuli, the P. gingivalis-derived factors causing the phenomena seem to be trypsin-like proteases.
Tai
H
H
Department of Periodontology, Niigata University School of Dentistry, Japan.
Kobayashi
T
T
Hara
K
K
D006801:Humans; D016177:Macrophage-1 Antigen / Q000032:analysis*; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D016966:Porphyromonas gingivalis / Q000276:immunology*; D011480:Protease Inhibitors / Q000494:pharmacology; D017463:Receptors, Complement 3b / Q000032:analysis*; D017452:Receptors, IgG / Q000032:analysis*
D016177:Macrophage-1 Antigen; D011480:Protease Inhibitors; D017463:Receptors, Complement 3b; D017452:Receptors, IgG