Upstream region of a nuclear gene encoding the alpha-subunit of the human mitochondrial F0F1 ATP synthase.
An expressed nuclear gene (ATPA) that encodes the alpha-subunit of the human mitochondrial F0F1 ATP synthase complex was isolated from a human genomic library. The nucleotide sequence of the 5'-flanking region of this gene was determined. No typical TATA or CCAAT boxes were found in this region. The 5'-flanking region of this gene contains several sequences that are found in a number of nuclear genes that encode proteins of the mitochondrial oxidative phosphorylation system and which might play a role in regulating their expression. The nucleotide sequence of the 5'-flanking region of the human ATPA gene is highly homologous (overall homology approx. 70%) to the corresponding region of the bovine ATPA1 gene.
Department of Molecular and Cell Biology, University of Texas, Dallas, Richardson 75083-0688.
E M
EM
Jordan
G A
GA
Breen
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000201:enzymology; D008969:Molecular Sequence Data; D006180:Proton-Translocating ATPases / Q000235:genetics*; D014162:Transfection
D015500:Chloramphenicol O-Acetyltransferase; D006180:Proton-Translocating ATPases