[Study of combined hepatocellular and cholangiocarcinoma].
Four patients with combined hepatocellular and cholangiocarcinoma were studied. One case received hepatic arterial infusion therapy (HAIT), 2 hepatectomy and the case with extrahepatic cholangiocarcinoma underwent enucleation. According to Allen's classification, two were combined type and the others mixed type. Tumor ploidy patterns on flow cytometric DNA analysis were aneuploid in 2 cases with curative resection, of which one is still alive 6 years and 3 months after surgery. It suggested that the patient's survival was affected by the pathological factors more than the ploidy patterns of the tumor. A case treated by HAIT improved considerably in terms of symptoms and evidenced reduction in the size of the deposits. Selection of anticancer agents sensitive to both hepatocellular and cholangiocarcinoma is required.
Shimoyama
T
T
1st Dept. of Surgery, Nagasaki University School of Medicine, Japan.
Shimizu
T
T
Miyashita
K
K
Kusano
H
H
Jibiki
M
M
Akamine
S
S
Akama
Y
Y
Itoyanagi
N
N
Nakamura
A
A
Yasutake
T
T
D002759:Adenoma, Bile Duct / Q000235:genetics / Q000473:pathology*; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011379:Prognosis
D004273:DNA, Neoplasm