[Complicated febrile convulsion vs herpes-encephalitis].
Since Acyclovir is available a sufficient treatment of herpes simplex virus (HSV) encephalitis exists. Febrile convulsions may occur as the initial manifestation of an encephalitis, particularly of an HSV encephalitis. Within 25 months out of 151 children with febrile convulsions five children with complicated febrile convulsions were admitted at the pediatric department of Graz. In all children HSV antibodies in serum and cerebrospinal fluid (CSF) were negative and the diagnosis of an HSV encephalitis was made by positive CSF HSV polymerase chain reaction (PCR). Therefore, in any suspected case, i.e. in any case of a complicated febrile convulsion, CSF should be investigated including a HSV PCR to rapidly confirm or exclude HSV encephalitis.
Universitäts-Kinderklinik Graz, Osterreich.
M
M
Millner
D000212:Acyclovir / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000201:enzymology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D016133:Polymerase Chain Reaction; D012640:Seizures / Q000175:diagnosis / Q000209:etiology*; D018139:Simplexvirus / Q000187:drug effects*
D000212:Acyclovir