[Prevention of iodine-induced hyperthyroidism after coronary angiography].
Coronary angiography (CA) is followed by an iodine load of 15 to 20 mg for the thyroid and may be the cause of iodine-induced hyperthyroidism. 60 consecutive patients hospitalized for CA without any thyroid history were examined and 56 had thyroid diseases with normal thyroid function. 33 patients still showed a significant decrease of 20 min Technetium uptake (TcU) and an increase of urine iodine excretion because of iodine excess 12 weeks after CA. 3 patients developed latent hyperthyroidism. 27 patients received medication of 1 g natrium-perchlorate and 60 mg methimazole 24 hours before and on the day of CA. These patients showed normal TcU and urine iodine excretion 4 and 12 weeks after CA. 1 out of these 27 patients developed overt hyperthyroidism but had PTCA without premedication 2 weeks after CA. Since Iodine excess leads to iodine-induced hyperthyroidism even in euthyroids a prophylaxis with perchlorate and methimazole is generally recommended in patients with CA.
Abteilung für Nuklearmedizin, Landeskrankenhauses Feldkirch.
H
H
Fritzsche
W
W
Benzer
W
W
Furlan
D
D
Hammerle
W
W
Langsteger
P
P
Weiss
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000517:prevention & control; D007455:Iodine / Q000009:adverse effects*; D008297:Male; D008713:Methimazole / Q000008:administration & dosage; D008875:Middle Aged; D010472:Perchlorates / Q000008:administration & dosage; D011292:Premedication; D017670:Sodium Compounds; D013960:Thyroid Function Tests
D003287:Contrast Media; D010472:Perchlorates; D017670:Sodium Compounds; D008713:Methimazole; D007455:Iodine; C031068:sodium perchlorate