Evidence for the long-term biological distribution of Technegas particles.
Technegas is a suspension of structured graphite ellipsoids, between 5 and 20 nm in aerodynamic diameter and labelled, in a carrier gas of argon, with 99Tcm. Its emergence and rapidly expanding clinical usage (105,000 studies, 22 countries), as a unique dry insoluble microaerosol for diagnostic lung imaging, has prompted a review of reports of experiments on lung clearance with other aerosols. No direct comparison exists although it is clear that experimental inhalation insults which deliver to the alveoli a mass of material orders of magnitude greater than Technegas are well tolerated by human volunteers.
Department of Medicine and Clinical Science, J.C.S.M.R., Australian National University, Canberra.
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Burch
D000336:Aerosols / Q000493:pharmacokinetics; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D013997:Time Factors
D000336:Aerosols; C056708:Technegas; D013670:Sodium Pertechnetate Tc 99m