Development of human papillomavirus-associated Buschke-Löwenstein penile carcinoma during cyclosporine therapy for generalized pustular psoriasis.
Buschke-Löwenstein-type giant penile condyloma developed in a human immunodeficiency virus-negative, 25-year-old man after 4 years of intermittent cyclosporine therapy (5 mg/kg/day) for pustular psoriasis. Microscopic examination showed multifocal areas of invasive squamous cell carcinoma. Dot blot analysis of amplified polymerase chain reaction products with primers directed at the L1 region demonstrated signals for several human papillomavirus genotypes, including human papillomavirus type 16, that correlated with different histologic patterns consisting of verrucous and bowenoid changes and invasive carcinoma. This case conforms to the enhanced risk of cutaneous carcinogenesis from either papillomavirus infection or chronic actinic damage that has become evident in patients with organ allografts and cyclosporine therapy.
Piepkorn
M
M
Department of Medicine (Dermatology), University of Washington School of Medicine, Seattle 98195.
Kumasaka
B
B
Krieger
J N
JN
Burmer
G C
GC
D000328:Adult; D003218:Condylomata Acuminata / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D015344:DNA Probes, HPV / Q000032:analysis; D006801:Humans; D008297:Male; D027383:Papillomaviridae; D010412:Penile Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics; D016133:Polymerase Chain Reaction; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy; D013997:Time Factors; D014412:Tumor Virus Infections / Q000139:chemically induced* / Q000175:diagnosis
D015344:DNA Probes, HPV; D016572:Cyclosporine