[3 years experience with the Capture-R-Solid Phase antibody identification test].
Solid-phase capture methodology is very helpful to find and identify red cell antibodies. Cold agglutinins like anti-I, anti-H, anti-IH, anti-P1, anti-Lea, anti-Leb, anti-M, or anti-N cannot be detected if they are isolated IgM class antibodies. It is very doubtful that these antibodies are of any clinical importance. We missed one IgM Anti-Lea, but we found additional 40 IgG class antibodies with known clinical importance which neither could be detected nor identified by conventional test procedures.
Blutspendezentrale Saarland, Stadt Saarbrücken, BRD.
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D000373:Agglutinins / Q000032:analysis; D001782:Blood Donors; D001788:Blood Grouping and Crossmatching; D003450:Cryoglobulins; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007518:Isoantibodies / Q000032:analysis*; D011237:Predictive Value of Tests
D000373:Agglutinins; D003450:Cryoglobulins; D007075:Immunoglobulin M; D007518:Isoantibodies; C029443:cold agglutinins