Hepato-biliary and renal excretion in mice of charged and neutral gadolinium complexes of cyclic tetra-aza-phosphinic and carboxylic acids.
Tissue distribution of 21 new 157/153Gd complexes was measured at 5 min and 24 hr after an intravenous injection into mice. A complex was judged to be stable in vivo when the percentage of 153Gd retained in the liver and skeleton at 24 hr was comparable with that of 153Gd(DOTA)-. Complexes varied in net charge and lipophilicity and 20 were phosphinic or carboxylic acid derivatives of tetra-aza-cyclo-dodecane. Three anionic, lipophilic complexes were cleared predominantly by the hepato-biliary pathway and were stable in vivo. The remaining 18 complexes were cleared mainly by the kidneys. Of these 18, 1 anionic, 8 neutral, and 3 cationic complexes were stable in vivo. These findings augur well for the future of hepato-biliary and general purpose Gd contrast enhancing agents for MRI.
Medical Research Council, Radiobiology Unit, Chinton, Oxon, UK.
A
A
Harrison
C A
CA
Walker
K A
KA
Pereira
D
D
Parker
L
L
Royle
K
K
Pulukkody
T J
TJ
Norman
D000818:Animals; D001659:Biliary Tract / Q000378:metabolism*; D003287:Contrast Media; D005682:Gadolinium; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009942:Organometallic Compounds; D013997:Time Factors; D014018:Tissue Distribution
D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium