Quinolones and macrolides: roles in respiratory infections.
Newer agents in these classes can be useful when standard antibiotics may be contraindicated or ineffective. They are well tolerated gastrointestinally and have excellent tissue penetration when given orally, allowing shorter courses at lower dosages. Quinolones are especially effective against nosocomial infections, macrolides against community-acquired infections.
Khan
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State University of New York, Stony Brook Health Sciences Center School of Medicine, N.Y.
D042462:4-Quinolones; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002985:Clinical Protocols / Q000592:standards; D004250:DNA Topoisomerases, Type II / Q000187:drug effects; D003663:Decision Trees; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D018942:Macrolides; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012333:RNA, Messenger / Q000187:drug effects; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D018942:Macrolides; D012333:RNA, Messenger; D004250:DNA Topoisomerases, Type II