[Hemodynamic changes in waking rats with acute streptozotocin diabetes after administration of the combined V2/V1 vasopressin antagonist].
The hemodynamic effect of combined V2/V1 arginine vasopressin (AVP) antagonist in conscious rats with acute 24 hour streptozotocin (STZ)--induced diabetes was studied using the microsphere technique. The rats were made diabetic with a single intravenous injection of STZ (60 mg/kg). One day after STZ administration the hemodynamic parameters in the experimental animals were measured before and 10 minutes after AVP antagonist injection (50 mg/kg, i.v.). The hemodynamic alterations observed post-antagonist included: 1) an increase in the total peripheral resistance (1.84 +/- 0.15 vs. 1.31 +/- 0.12 mm Hg/ml/min per 100 g before antagonist administration, p < 0.05), 2) a decrease in the cardiac index (49.0 +/- 3.1 vs. 68.7 +/- 5.2 ml/min/100 g before antagonist administration, p < 0.05) and stroke volume (0.40 +/- 0.03 vs. 0.57 +/- 0.06 ml before antagonist administration, p < 0.05), 3) a significant (p < 0.05) decrease in the blood flow to the skin, skeletal muscle, stomach, small intestine and kidneys. The mean arterial pressure and heart rate remained unchangeable post-antagonist. These data suggest that AVP is responsible, at least in part, for prominent hemodynamic alterations observed in conscious rats with 24 hour STZ-induced diabetes.
L V
LV
Kuznetsova
N A
NA
Medvedeva
O S
OS
Medvedev
D000208:Acute Disease; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D051381:Rats; D017483:Receptors, Vasopressin / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014667:Vasopressins / Q000037:antagonists & inhibitors*; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D017483:Receptors, Vasopressin; C094084:vasopressin, 1-adamantanacetyl-2-(O-ethyl)Tyr-4-Val-6-aminobutyryl-8,9-Arg-; D014667:Vasopressins; D001127:Arginine Vasopressin