Excitatory amino acid receptors and epilepsy.
The rapid pace of discovery in the molecular biology of glutamate receptors includes advances concerning the N-methyl-D-aspartate receptor. New information emerging in this area is already affecting the study of epilepsy in animal models and provides novel opportunities to extrapolate directly to human disease through isolation and chromosomal localization of human glutamate receptor genes. These discoveries are being exploited for improved understanding and treatment of human epilepsy.
Department of Neurology, Duke University Medical Center, Durham, NC 27710.
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McNamara
D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000503:physiopathology; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology; D017774:Long-Term Potentiation / Q000235:genetics / Q000502:physiology; D017470:Receptors, Glutamate / Q000235:genetics / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000502:physiology*
D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate