[CD23: structures, functions and practical perspectives in allergy reactions].
CD23, the low-affinity receptor for IgE, is a surface cell marker and surface CD23 is cleaved into soluble fragments by an autocatalytic mechanism. cDNA clone encoding for CD23 has been isolated and structural studies realized. CD23 is expressed by B and T lymphocytes and by other cells including tumor cells. IL4 and IgE are the most potent inducer of CD23 expression. CD23 has multiple functions: B cell growth and differentiation, capacity to present antigen, cellular mobility, inflammation... The serum sCD23 level is often increased in allergic patients.
Département de pédiatrie, pavillon S, hôpital E-Herriot, Lyon, France.
A
A
Lachaux
D
D
Kaiserlian
D002462:Cell Membrane / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D017455:Receptors, IgE / Q000502:physiology / Q000648:ultrastructure
D017455:Receptors, IgE