Neuropsychological deficits in abstinent cocaine abusers: preliminary findings after two weeks of abstinence.
Sixteen subjects hospitalized for treatment of cocaine dependence were administered a battery of neuropsychological tests within 72 h of last cocaine use and again approximately 2 weeks later. Twenty-one non-cocaine using control subjects, matched for age, gender, ethnicity and education, also received neuropsychological testing. Abstinence from mood altering substances during the 2-week study period was verified for both groups on three occasions using quantitative urine analysis. The results suggest that recent cocaine use is associated with impairment in memory, visuospatial abilities, and concentration during the acute phase of withdrawal, independent of withdrawal-related depression. Furthermore, many of these deficits appear to persist at least 2 weeks beyond cessation of cocaine use.
Alcohol and Drug Treatment Program, West Los Angeles VA Medical Center, Brentwood Division, CA 90073.
J
J
Berry
W G
WG
van Gorp
D S
DS
Herzberg
C
C
Hinkin
K
K
Boone
L
L
Steinman
J N
JN
Wilkins
D000328:Adult; D003042:Cocaine / Q000009:adverse effects*; D003210:Concept Formation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000187:drug effects; D011340:Problem Solving / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D015813:Substance Abuse Detection; D016320:Substance Abuse Treatment Centers; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000523:psychology; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
D003042:Cocaine