Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour.
The molecular characterization of a human testicular proteoglycan, the progenitor of a seminal plasma glycosaminoglycan-bearing peptide, was achieved by cDNA cloning. Its protein core encompasses several domains encountered in various proteins associated with adhesion, migration and cell proliferation. An osteonectin-like domain, a Kazal-like sequence and a 46-amino-acid motif around a Cys-Trp-Cys-Val peptide encountered in cell-surface antigens, cell-adhesion molecules and growth-factor-binding proteins are distributed within the testican protein core. Testican is the progenitor of the unique heparan/chondroitin-sulfate-bearing peptide present in human seminal plasma, a feature which might confer additional potentialities to this hybrid proteoglycan.
Centre National de la Recherche Scientifique URA 1188, Université Paris V, France.
P M
PM
Alliel
J P
JP
Perin
P
P
Jollès
F J
FJ
Bonnet
D018171:Agrin; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry; D015676:Osteonectin / Q000737:chemistry; D011498:Protein Precursors / Q000737:chemistry* / Q000235:genetics; D011509:Proteoglycans / Q000737:chemistry* / Q000235:genetics; D013737:Testis / Q000737:chemistry*; D013954:Thyroglobulin / Q000737:chemistry
D018171:Agrin; D009419:Nerve Tissue Proteins; D015676:Osteonectin; D011498:Protein Precursors; D011509:Proteoglycans; D004247:DNA; D013954:Thyroglobulin