Involvement of alpha 1- but not alpha 2-adrenergic systems in the antagonizing effect of paeoniflorin on scopolamine-induced deficit in radial maze performance in rats.
Paeoniflorin, a major constituent of peony root (1 mg/kg, p.o.), attenuated scopolamine-induced deficit in radial maze performance. Both prazosin (0.5 mg/kg, i.p.) and yohimbine (0.3 mg/kg, i.p.) neither impaired radial maze performance by itself nor augmented the scopolamine-induced performance deficit. Prazosin significantly blocked the antagonizing effect of paeoniflorin on the scopolamine deficit, whereas yohimbine did not affect the paeoniflorin effect. These data suggest that the alpha 1-adrenergic but not alpha 2-adrenergic systems are involved in the antagonizing effect of paeoniflorin on the scopolamine deficit in radial maze performance in rats.
Section of Pharmacology, Research Institute for Wakan-Yaku, Japan.
H
H
Ohta
K
K
Matsumoto
H
H
Watanabe
M
M
Shimizu
D000818:Animals; D001565:Benzoates; D001952:Bridged-Ring Compounds; D005960:Glucosides / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D039821:Monoterpenes; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D012601:Scopolamine / Q000037:antagonists & inhibitors*; D015016:Yohimbine / Q000494:pharmacology; D006027:Glycosides
D001565:Benzoates; D001952:Bridged-Ring Compounds; D005960:Glucosides; D039821:Monoterpenes; D011224:Prazosin; D011942:Receptors, Adrenergic, alpha; D012601:Scopolamine; D015016:Yohimbine; C015423:peoniflorin; D006027:Glycosides