[Expression of human papillomavirus (HPV) gene in HPV-positive laryngeal tumors and activity of the HPV long control region in cultured normal laryngeal epithelial cells].
Expression of the human papillomavirus (HPV) gene was examined in HPV-positive laryngeal tumors. Moreover, the activity of the HPV long control region (LCR) was tested in cultured laryngeal epithelial cells. HPV-11 early genes were heterogeneously expressed in adult laryngeal papillomas. We found one laryngeal carcinoma case in whom the HPV-16 transforming genes, E6 and E7, were expressed. Both HPV-11 and -16 LCRs were active in cultured laryngeal epithelial cells from vocal cords. These results suggest that laryngeal epithelial and tumor cells are target cells for HPV gene expression.
Tsutsumi
K
K
Department of Otorhinolaryngology, St. Marianna University School of Medicine, Kawasaki.
Hoshikawa
T
T
Suzuki
T
T
Takeyama
I
I
D000328:Adult; D000368:Aged; D015344:DNA Probes, HPV; D004848:Epithelium / Q000382:microbiology; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000382:microbiology; D007830:Larynx / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D027383:Papillomaviridae / Q000235:genetics*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D015344:DNA Probes, HPV