Experimental galactose neuropathy: quantitative changes in intramembranous particles in fracture faces of the perineurium.
Peripheral nerves in rats fed a diet containing 40% galactose develop endoneurial oedema related to the accumulation of interstitial galactitol and sodium. Biochemical studies of the perineurium in galactose neuropathy indicate an increase in membrane bound Na+/K(+)-ATPase activity. The present study has analysed the intramembraneous particles (IMPs) on the P membrane fracture faces of the perineurium in galactose-fed rats and has demonstrated a significant increase in the density of IMPs. This finding may reflect changes in the perineurial cell membranes in galactose neuropathy, such as increased membrane bound Na+/K(+)-ATPase activity.
Department of Anatomy and Cell Biology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
N G
NG
Beamish
C
C
Stolinski
P K
PK
Thomas
R H
RH
King
D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D005614:Freeze Fracturing; D005690:Galactose; D008565:Membrane Proteins / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008565:Membrane Proteins; D005690:Galactose