Naftidrofuryl affects neurite regeneration by injured adult auditory neurons.
Afferent auditory neurons are essential for the transmission of auditory information from Corti's organ to the central auditory pathway. Auditory neurons are very sensitive to acute insult and have a limited ability to regenerate injured neuronal processes. Therefore, these neurons appear to be a limiting factor in restoration of hearing function following an injury to the peripheral auditory receptor. In a previous study nerve growth factor (NGF) was shown to stimulate neurite repair but not survival of injured auditory neurons. In this study, we have demonstrated a neuritogenesis promoting effect of naftidrofuryl in an vitro model for injury to adult auditory neurons, i.e. dissociated cell cultures of adult rat spiral ganglia. Conversely, naftidrofuryl did not have any demonstrable survival promoting effect on these in vitro preparations of injured auditory neurons. The potential uses of this drug as a therapeutic agent in acute diseases of the inner ear are discussed in the light of these observations.
Department of Oto-Rhino-Laryngology, University of Liege, Belgium.
P P
PP
Lefebvre
H
H
Staecker
G
G
Moonen
T R
TR
van de Water
D000818:Animals; D002452:Cell Count; D002470:Cell Survival; D003470:Culture Media; D046508:Culture Techniques; D016222:Fibroblast Growth Factor 2; D007797:Laminin; D009257:Nafronyl / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010455:Peptides; D051381:Rats; D017208:Rats, Wistar; D013136:Spiral Ganglion / Q000187:drug effects* / Q000293:injuries* / Q000503:physiopathology
D003470:Culture Media; D007797:Laminin; D010455:Peptides; D016222:Fibroblast Growth Factor 2; C008973:polyornithine; D009257:Nafronyl