QT prolongation by isoproterenol in anorexia nervosa.
A 17-year-old male with anorexia nervosa developed atypical prolongation of his corrected QT interval (QTc) when placed on isoproterenol for profound sinus bradycardia. His QTc normalized after the infusion was discontinued. Autonomic imbalance may explain the observed QTc lengthening. Because bradycardia associated with weight loss in anorexia is usually a physiologic adaptation and rarely symptomatic, aggressive chronotropic therapy may be not only unwarranted, but potentially deleterious.
Harris
J P
JP
Department of Pediatrics, University of Rochester Medical Center, New York 14642.
Kreipe
R E
RE
Rossbach
C N
CN
D000293:Adolescent; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology; D003866:Depressive Disorder / Q000523:psychology; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage / Q000009:adverse effects*; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000503:physiopathology / Q000523:psychology; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000523:psychology
D007545:Isoproterenol