Influence of the radioprotective agent WR 2721 on the striatal acetylcholinesterase activity in the rat.
The radioprotective thiophosphate S-2(3 amino-propyl-amino) phosphorothioic acid (WR 2721) induced an early reduction of striatal acetylcholinesterase activity followed by an increase, when intraperitoneally injected to rats, although it does not cross the blood-brain barrier. These results were obtained using an original technique which allows the measurements in the same animal for several days. Transient general oxidative metabolism inhibition might affect the extra-cellular enzyme amount or its activity.
Département de Radiobiologie, Centre de Recherche du Service de Santé des Armées, La Tronche, France.
D
D
Clarençon
M
M
Galonnier
G
G
Testylier
M
M
Fatôme
D000110:Acetylcholinesterase / Q000187:drug effects*; D004999:Amifostine / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000110:Acetylcholinesterase; D004999:Amifostine