The paraoxonase polymorphism in a Saudi Arabian population.
The paraoxonase polymorphism was analysed in the serum of 248 individuals from Saudi Arabia. The phenotyping method used was one based on the ratio of paraoxonase/arylesterase, described in earlier studies. The distribution of this ratio in the sample was trimodal and it provided a good resolution for the identification of three phenotypes: A-homozygotes with low activity; B-homozygotes with high activity; AB-the corresponding heterozygotes, with intermediate activity. Gene frequencies were 0.7296 for the allele A with low activity and 0.2704 for the allele B with high activity. These frequencies are close to those observed in Caucasian samples from North America and Europe. Phenotypic frequencies in the sample fit the Hardy-Weinberg equilibrium.
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109.
C P
CP
Nogueira
D A
DA
Evans
B N
BN
La Du
D000328:Adult; D043303:Aryldialkylphosphatase; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D005260:Female; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010744:Phosphoric Monoester Hydrolases / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D012529:Saudi Arabia
D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase