Lineage promiscuity in leukemia studies of T-cell receptor and immunoglobulin genes.
Using appropriate DNA probes, the configurations of the T-cell receptor beta-chain genes and immunoglobulin heavy-chain genes were studied in patients diagnosed as having the following malignancies: 7 chronic myeloid leukemia, 13 acute myeloblastic leukemia, 9 acute lymphocytic leukemia and 20 chronic lymphocytic leukemia. Rearrangements not corresponding to the immunotype were unexpectedly found in lineage neoplasias.
Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, Clermont-Ferrand, France.
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D
Bernard
Y J
YJ
Bignon
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F
Lavenue
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J
Pauchard
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F
Demeocq
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P
Travade
P
P
Philippe
M
M
Legros
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Cure
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J
Chassagne
D002051:Burkitt Lymphoma / Q000097:blood / Q000235:genetics; D015321:Gene Rearrangement; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D005803:Genes, Immunoglobulin; D005838:Genotype; D006801:Humans; D016130:Immunophenotyping; D007938:Leukemia / Q000097:blood / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000235:genetics; D015461:Leukemia, Prolymphocytic, T-Cell / Q000097:blood / Q000235:genetics; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000235:genetics