Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury.
Core temperature was measured in rats 24 hr. after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine. An extraordinarily powerful interaction was noted among seizures, physical restraint, and acepromazine-produced hypothermia (24 degrees C) compared to the other 7 treatments (> 35 degrees C). The putative poikilothermic response is commensurate with the loss of mammalian behaviors that follow these seizures. Implications for survival during the acute stages of brain injury are suggested.
Bureau
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Laurentian University, Sudbury, Ontario, Canada.
Persinger
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MA
D000075:Acepromazine / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology*; D002712:Chlorides; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D008032:Limbic System / Q000187:drug effects* / Q000503:physiopathology; D008094:Lithium; D018021:Lithium Chloride; D008297:Male; D009474:Neurons / Q000502:physiology; D010862:Pilocarpine; D051381:Rats; D012149:Restraint, Physical; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013226:Status Epilepticus / Q000139:chemically induced / Q000503:physiopathology
D002712:Chlorides; D010862:Pilocarpine; D000075:Acepromazine; D008094:Lithium; D018021:Lithium Chloride