A formulation for correlating properties of peptides and its application to predicting human immunodeficiency virus protease-cleavable sites in proteins.
A mathematical frame has been established to generally formulate the correlating properties of peptides. The formulation can be used to study the specificity of multisite enzymes, particularly in predicting the susceptible sites in proteins by human immunodeficiency virus (HIV) proteases, and hence can serve as a supplementary means in designing HIV protease inhibitors as potential drugs against acquired immunodeficiency syndrome.
Chou
J J
JJ
Department of Physics, University of Michigan, Ann Arbor 48104.
D000595:Amino Acid Sequence; D001665:Binding Sites; D015195:Drug Design; D016333:HIV Protease / Q000378:metabolism*; D017320:HIV Protease Inhibitors / Q000737:chemistry; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011506:Proteins; D016333:HIV Protease