Lack of preferential V beta usage in synovial T cells of rheumatoid arthritis patients.
The T-cell receptor V beta subfamily repertoires of synovial and peripheral T cells of 8 rheumatoid arthritis (RA) patients were determined using the polymerase chain reaction. Three normal controls were included. Some of the rheumatoid synovial samples did not express the complete range of V beta families and lacked as many as 6 gene families. However, these patients showed considerable individual variation in expression. Overall, the data do not support preferential T-cell receptor V beta usage in synovial T cells of RA patients either in comparison to their autochthonous peripheral T cells or to peripheral T cells of normal subjects.
Department of Microbiology, Istanbul School of Medicine, Turkey.
F
F
Dedeoglu
H
H
Kaymaz
N
N
Seaver
S F
SF
Schluter
D E
DE
Yocum
J J
JJ
Marchalonis
D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology; D001483:Base Sequence; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D013583:Synovial Membrane / Q000473:pathology*; D013601:T-Lymphocytes
D016693:Receptors, Antigen, T-Cell, alpha-beta