Morphine effect on proliferation of normal and tumor cells of immune origin.
The influence of morphine on proliferation of human tumor K562 and lymphoid cells was studied and compared with that on the mitogen-induced proliferation of human peripheral blood mononuclear cells (PBMC). Morphine was shown to act as a suppressor of both cellular DNA synthesis (50% and more as compared to control) and the cellular population growth of mitogen-induced PBMC, B-lymphoma Namalva cells and EBV-transformed lymphocytes. Morphine activated proliferation of myeloid K562 and T-lymphoma Yurkat cells 1.5-fold. It is supposed that the opposite effects of morphine on proliferation of cell lines of immune origin reveal the difference in modulation of diverse immune cell types by morphine.
A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia.
M G
MG
Sergeeva
Z V
ZV
Grishina
S D
SD
Varfolomeyev
D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D004854:Herpesvirus 4, Human; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D016393:Lymphoma, B-Cell / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000473:pathology; D008934:Mitogens / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000473:pathology; D014407:Tumor Cells, Cultured
D008934:Mitogens; D009020:Morphine