BCR-ABL rearrangement in a child with acute myelogenous leukaemia without a Philadelphia chromosome.
We describe a BCR/ABL rearrangement positive but Philadelphia chromosome negative status in a 9-year-old boy suffering from an acute myelogenous leukaemia (AML). This case was detected in a prospective PCR screening procedure including 21 children with newly diagnosed AML and 150 children with acute lymphoblastic leukaemia (ALL). We found a 5.4% incidence of BCR/ABL rearrangement positive cases in pre-B and c-ALL in childhood.
Department of Paediatric Oncology, Children's University Hospital, Giessen, Germany.
A
A
Borkhardt
R
R
Repp
J
J
Harbott
M
M
Lakomek
J W
JW
Janssen
S
S
Schlieben
C R
CR
Bartram
F
F
Lampert
D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis; D015321:Gene Rearrangement; D016313:Genes, abl / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction
D004273:DNA, Neoplasm