(6R)-6-(substituted methyl)penicillanic acid sulfones: new potent beta-lactamase inhibitors.
A series of (6R)-6-(substituted methyl)penicillanic acid sulfones has been prepared starting from the corresponding 6-(substituted methylene)penicillanates. The new sulfones 9a, 9b, 9c and 9d have been shown to be potent beta-lactamase inhibitors.
F. Hoffmann-La Roche AG, Basel, Switzerland.
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D000818:Animals; D051379:Mice; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000138:chemical synthesis / Q000494:pharmacology*; D018805:Sepsis / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors
D013450:Sulfones; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid