Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle.
Eighteen of 91 seven- to nine-month-old Belgian white and blue double-muscled male fattening cattle developed typical signs of shipping fever. They were all injected intramuscularly once a day for three days with 5 mg/kg of enrofloxacin, and in addition nine selected at random were injected intramuscularly five times at 12 hour intervals with 0.1 mg/kg of metrenperone, a 5-hydroxytryptamine blocker, the other nine receiving a placebo. During the outbreak of shipping fever metrenperone showed effective antipyretic properties, and all the calves treated with it made a complete recovery. Moreover, during the 360 day fattening period following the outbreak, the cattle treated with metrenperone gained on average 45.4 kg more weight than the control cattle.
Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Belgium.
B
B
Genicot
F
F
Mouligneau
F
F
Rollin
J K
JK
Lindsey
R
R
Close
P
P
Lekeux
D000818:Animals; D000890:Anti-Infective Agents; D002417:Cattle; D004196:Disease Outbreaks / Q000662:veterinary*; D004359:Drug Therapy, Combination; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D012766:Pasteurellosis, Pneumonic / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015363:Quinolones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012119:Respiration; D012129:Respiratory Function Tests / Q000662:veterinary; D015430:Weight Gain
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010880:Piperidines; D015363:Quinolones; D000077422:Enrofloxacin; C046881:metrenperone