Zaprinast, cicletanine, and verapamil attenuate overdrive pacing-induced myocardial ischemia in conscious rabbits.
In conscious rabbits equipped with right ventricular electrode and left ventricular polyethylene catheters, zaprinast and cicletanine, inhibitors of phosphodiesterase (PDE) V and PDEs I and V, respectively, as well as verapamil, a Ca2+ channel blocker, decreased intracavital ST-segment elevation induced by ventricular overdrive pacing (VOP). Zaprinast and cicletanine attenuated VOP-induced QT reduction and increase in left ventricular end-diastolic pressure (LVEDP), whereas verapamil increased LVEDP. These results suggest that inhibition of cGMP-PDEs can protect heart against ischemia.
Szilvassy
Z
Z
First Department of Medicine, Albert Szent-Györgyi University Medical School of Szeged, Hungary.
Jakab
I
I
Ferdinandy
P
P
Koltai
M
M
Lonovics
J
J
Tarrade
T
T
Braquet
P G
PG
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D006352:Heart Ventricles / Q000187:drug effects; D006439:Hemodynamics; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D011688:Purinones / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D011817:Rabbits; D014700:Verapamil / Q000627:therapeutic use*
D011688:Purinones; D011725:Pyridines; C038068:cicletanine; D014700:Verapamil; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; C011145:zaprinast