Magnesium sulphate increases lymphocyte adenosine 3':5'-cyclic monophosphate in humans.
We determined the effect of i.v. magnesium sulphate, which is often combined with beta 2-adrenoceptor agonists for tocolytic therapy, on lymphocyte cyclic AMP production, extracellular magnesium and blood calcium concentrations. Sixteen healthy volunteers received i.v. magnesium sulphate 1 g h-1 over 8 h; seven volunteers also had infusion of NaCl 18 mg h-1 as control. Venous blood was taken pre- and post-infusion to determine basal lymphocyte cyclic AMP and the increase evoked by 0.1 mM isoprenaline, as well as serum and plasma concentrations of total and non-protein-bound magnesium and calcium. Following magnesium sulphate there was a significant rise in the isoprenaline-evoked increase in cyclic AMP (P < 0.05) and in the magnesium concentrations (P < 0.01) and a decrease in the free calcium concentration (P < 0.01).
Department of Obstetrics, University of Zurich, Switzerland.
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Von Mandach
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Bürgi
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Huch
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Huch
D000328:Adult; D002118:Calcium / Q000097:blood; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male
D008278:Magnesium Sulfate; D000242:Cyclic AMP; D008274:Magnesium; D007545:Isoproterenol; D002118:Calcium