[Interaction of NAD with the GABA-ergic system of the rat brain].
After administration of corazole content of gamma-aminobutyric acid (GABA) was increased in the rat brain within 2 min and 10 min by 28% and 80%, respectively. Content of the GABA was distinctly decreased in the prespastic phase. During this period specific binding of 3H-muscimol to the GABA receptors was decreased. NAD at concentrations 10(-6) M and 10(-7) M activated the GABA receptors and inhibited binding of 14C-GABA to the synaptosomes of both intact rats and the animals treated with the convulsant agent. NAD appears to cause an effect as an inhibitory neurotransmitter at the postsynaptic level.
A I
AI
Fomenko
P K
PK
Parkhomets
G V
GV
Donchenko
S P
SP
Stepanenko
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D009118:Muscimol / Q000378:metabolism; D009243:NAD / Q000378:metabolism* / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000032:analysis; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000737:chemistry / Q000378:metabolism*
D011963:Receptors, GABA-A; D009243:NAD; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D010433:Pentylenetetrazole