[In vitro differentiation and Fc receptor expression of eosinophils].
Eosinophils express Fc gamma R II, together with some, if any, Fc gamma R I or Fc gamma R III. Fc epsilon R II is thought to be expressed only on the hypodense subpopulation of eosinophils. Dibutyryl cyclic AMP (dbcAMP) and gamma interferon (IFN-gamma) enhanced Fc gamma R II expression on both peripheral eosinophils and eosinophils derived in vitro by IL-5 from cord blood monoclear cells. IFN-gamma also enhanced Fc gamma R III expression on peripheral eosinophils only and not on IL-5-generated eosinophils. dbcAMP suppressed the IFN-gamma-induced Fc gamma R III expression on peripheral eosinophils. Other cytokines tested did not show any effect on Fc gamma R or Fc epsilon R II expression. These results suggest that expression of Fc gamma R subclasses and Fc epsilon R II on eosinophils is regulated differently and that cAMP and IFN-gamma play important roles in the regulation of Fc gamma R expression.
Department of Pediatrics, Hyogo Prefectural Tsukaguchi Hospital.
H
H
Akutagawa
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Mayumi
D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation; D002478:Cells, Cultured; D004804:Eosinophils / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology / Q000502:physiology; D017455:Receptors, IgE / Q000378:metabolism*; D017452:Receptors, IgG / Q000378:metabolism*
D017455:Receptors, IgE; D017452:Receptors, IgG; D003994:Bucladesine; D007371:Interferon-gamma