Netropsin inhibits the increase of intracellular Ca(2+)-dependent serine proteinase activity in sporulating Bacillus megaterium.
Netropsin suppressed the increase of intracellular proteolytic activity when added to B. megaterium incubated in a sporulation medium. The inhibited enzyme was a Ca(2+)-dependent serine proteinase. Sporulation and protein turnover in later sporulation phases were inhibited as well. Different concentrations of netropsin affected various aspects of protein catabolism differently.
Department of Cell and Molecular Microbiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.
H
H
Kucerová
J
J
Chaloupka
D001410:Bacillus megaterium / Q000187:drug effects / Q000201:enzymology*; D002118:Calcium / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D009024:Morphogenesis / Q000187:drug effects; D009429:Netropsin / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000096:biosynthesis* / Q000187:drug effects; D013171:Spores, Bacterial / Q000187:drug effects*
D009429:Netropsin; D012697:Serine Endopeptidases; D002118:Calcium