Phospholipase D and cell signaling.
Phospholipase D, which hydrolyzes phospholipids (primarily phosphatidylcholine) to generate phosphatidic acid, has emerged as a critical component in cellular signal transduction. Research during the past year has confirmed and extended the view that phosphatidic acid and its dephosphorylated product, sn-1,2-diacylglycerol, are important intracellular second messengers and that the coupling of phospholipase D to specific receptors occurs through multiple mechanisms involving protein kinase C, protein tyrosine kinase, Ca2+ and GTP-binding proteins.
Schering-Plough Research Institute, Kenilworth, New Jersey.
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D000818:Animals; D002118:Calcium / Q000502:physiology; D004075:Diglycerides / Q000502:physiology; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000502:physiology; D008563:Membrane Lipids / Q000378:metabolism; D008954:Models, Biological; D010712:Phosphatidic Acids / Q000502:physiology; D010739:Phospholipase D / Q000502:physiology*; D010743:Phospholipids / Q000378:metabolism; D011493:Protein Kinase C / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction
C011439:1,2-diacylglycerol; D004075:Diglycerides; D008563:Membrane Lipids; D010712:Phosphatidic Acids; D010743:Phospholipids; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C; D010739:Phospholipase D; D019204:GTP-Binding Proteins; D002118:Calcium