Pulmonary involvement by mycosis fungoides. A case showing angiocentric lesions and granulomas.
We describe an unusual case of pulmonary involvement by mycosis fungoides in a 31-year-old woman. Disseminated disease had developed despite cutaneous irradiation and systemic combination chemotherapy. Microscopy of biopsied tumour deposits in the lung showed a polymorphous, angiocentric lymphoid infiltrate, including atypical cells with convoluted nuclei which displayed a T-cell phenotype. Numerous epithelioid granulomas were also present. These histological appearances represent an unusual pattern of pulmonary involvement by disseminated mycosis fungoides.
Kitching
P A
PA
Department of Pathology, University Hospital of Wales, Cardiff, U.K.
Gibbs
A R
AR
D000328:Adult; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology*; D009182:Mycosis Fungoides / Q000150:complications / Q000473:pathology* / Q000628:therapy; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy