Flavonone and chalcone derivatives from Cryptocarya kurzii.
Four complex flavanones, kurziflavolactones A [2], B [3], C [4], and D [5] and a complex chalcone 6 with an unprecedented carbon side chain on the flavanone or chalcone A ring have been isolated from a Malaysian plant, Cryptocarya kurzii (Lauraceae). Their structures were determined by extensive spectroscopic analysis, especially 2D nmr experiments. Compounds 3 and 6 showed slight cytotoxicity against KB cells, with IC50 values of 4 and 15 micrograms/ml, respectively. A biosynthetic pathway for the formation of these compounds is suggested.
Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur- Yvette, France.
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Sévenet
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Remy
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Païs
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Hamid
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Zeng
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002599:Chalcone / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D010946:Plants, Medicinal / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C083159:kurziflavolactone A; C083160:kurziflavolactone C; D002599:Chalcone