Lack of association between HLA antigen DR3 and alpha 1-antitrypsin deficiency in liver transplant recipients.
The relationship between alpha 1-antitrypsin deficiency (alpha 1-ATD) and the HLA antigen system was studied in 32 liver transplant recipients. Despite previous reports of an association of HLA antigen DR3 with homozygosity for alpha 1-AT ZZ, no such association was seen in this population of alpha 1-ATD homozygous ZZ patients with advanced hepatic disease. Thus, the reported association of HLA class II antigens and homozygosity for the Z allele for alpha 1-AT may be an artifact of either a small study population or geographic inbreeding and a coincidental association of certain HLA antigens with the presence of homozygosity for the Z allele of alpha 1-AT.
Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania.
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A
Casavilla
R
R
Gordon
D H
DH
van Thiel
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TE
Starzl
D000293:Adolescent; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D015803:HLA-DR3 Antigen / Q000032:analysis*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012016:Reference Values; D019896:alpha 1-Antitrypsin Deficiency
D015803:HLA-DR3 Antigen