Abnormal pituitary-adrenocortical response in early HIV-1 infection.
The corticotropin-adrenocortical response to cold pressor challenge was investigated in a study of human immunodeficiency virus (HIV) infection. Data obtained from 16 HIV-1-positive and 28 HIV-1-negative subjects are presented in this report. After the insertion of a venicatheter and following 30 min of rest, the subjects immersed one of their hands in an ice-water mixture for 2 min, and serial blood samples were obtained for the determination of ACTH and cortisol levels. The results show a significant blunting in the ACTH response and marginally lower levels of cortisol, over all time points, in HIV-1-positive subjects compared to that in HIV-1-negative subjects.
Center for Biopsychosocial Studies on AIDS, University of Miami, School of Medicine, Florida.
M
M
Kumar
A M
AM
Kumar
R
R
Morgan
J
J
Szapocznik
C
C
Eisdorfer
D000324:Adrenocorticotropic Hormone / Q000097:blood; D003080:Cold Temperature; D015658:HIV Infections / Q000097:blood / Q000503:physiopathology*; D015497:HIV-1; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology*
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone