Macaque salivary proline-rich protein: structure, evolution, and expression.
Proline-rich proteins are a family of proteins that exhibit unique features including an unusual high proline content and salivary-specificity. As a major constituent in the salivary secretion of higher primates, proline-rich proteins may have biological roles in oral lubrication and protection. In this article, the genomic structure and regulation by cAMP of one of the macaque salivary proline-rich protein genes, MnP4, is reviewed. The evolution of this multigene family of proteins is also discussed.
Department of Pharmacology, University of Minnesota, Medical School, Minneapolis 55455.
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D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D015971:Gene Expression Regulation, Enzymologic; D008252:Macaca fascicularis; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000235:genetics*; D011392:Proline / Q000737:chemistry* / Q000235:genetics*; D055232:Proline-Rich Protein Domains; D012471:Salivary Proteins and Peptides / Q000737:chemistry* / Q000235:genetics*
D010455:Peptides; D012471:Salivary Proteins and Peptides; D011392:Proline