Antiherpes virus agents: a review.
In this review, after some considerations about the structure of the virus and the viral replicative cycle, herpes virus diseases in man are described. The most important antiherpes virus drugs until now discovered are then reported analyzing and examining their chemical structure related to their mechanism of action and their pharmacological activity. Finally, defects of antiherpes virus drugs currently in therapy are shown, in order to outline which directions future developments will have to follow.
Istituto di Chimica Farmaceutica e Tossicologica, Università di Pisa, Italy.
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Lapucci
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Macchia
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Parkin
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006564:Herpesviridae / Q000737:chemistry / Q000187:drug effects*; D006566:Herpesviridae Infections / Q000188:drug therapy; D006801:Humans
D000998:Antiviral Agents