Sexual differences in sensitivity to methamphetamine toxicity.
Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.
Department of Psychology, Rutgers University, New Brunswick, NJ.
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GC
Wagner
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Tekirian
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Cheo
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009420:Nervous System / Q000187:drug effects*; D012727:Sex Characteristics
D008694:Methamphetamine; D004298:Dopamine