(1S, 3R)-ACPD protects synaptic transmission from hypoxia in hippocampal slices.
The influence of (1S, 3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S, 3R)-ACPD], an agonist of the metabotropic glutamate receptor (mGluR), on recovery from in vitro hypoxia was investigated. Transverse hippocampal slices were exposed to a severe hypoxia, and the recovery of field excitatory postsynaptic potentials (fEPSPs) of CA1 neurons was monitored 1 hr after reoxygenation. If 20 microM (1S, 3R)-ACPD was present during hypoxia, the recovery of the fEPSPs was significantly higher compared to controls. This protective effect was not observed, when the mGluR-antagonist L-2-amino-3-phosphonopropionate (L-AP3, 300 microM) was coapplied with (1S, 3R)-ACPD.
Institute for Neurobiology, Department of Neurophysiology, Magdeburg, Germany.
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D000409:Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D018691:Excitatory Amino Acid Antagonists; C000211:2-amino-3-phosphonopropionic acid; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D000409:Alanine