Mos and the cell cycle: the molecular basis of the transformed phenotype.
The product of the mos proto-oncogene is a serine/threonine kinase that is expressed at high levels in germ cells. Mos is a regulator of meiotic maturation, and is required for the initiation and progression of oocyte meiotic maturation that leads to the production of unfertilized eggs. Mos is also a component of cytostatic factor, an activity that is believed to arrest oocyte maturation at meiotic metaphase II. There is evidence showing that the Mos protein is associated with tubulin in unfertilized eggs and transformed cells, raising the possibility that it is involved in the microtubular reorganization that occurs during M-phase. Inappropriate expression of its M-phase activity during interphase of the cell cycle may be responsible for its transforming activity.
Yew
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ABL-Basic Research Program, NCI-Frederick Cancer Research & Development Center, Maryland 21702.
Strobel
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M
Vande Woude
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GF
D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002453:Cell Cycle / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D016200:Maturation-Promoting Factor / Q000502:physiology; D008540:Meiosis; D008980:Moloney murine sarcoma virus / Q000235:genetics / Q000502:physiology; D017232:Oncogene Proteins v-mos / Q000235:genetics / Q000502:physiology*; D009865:Oocytes / Q000378:metabolism; D010641:Phenotype; D011494:Protein Kinases / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D017231:Proto-Oncogene Proteins c-mos / Q000235:genetics / Q000502:physiology*; D011519:Proto-Oncogenes; D008941:Spindle Apparatus / Q000378:metabolism
C000715470:MAS1 protein, human; D017232:Oncogene Proteins v-mos; D000090063:Proto-Oncogene Mas; D011494:Protein Kinases; D017231:Proto-Oncogene Proteins c-mos; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D016200:Maturation-Promoting Factor