Ischaemia-reperfusion injury in the rat kidney: effect of a single dose of sodium bicarbonate.
The protective effect of intravenous 8.4 per cent sodium bicarbonate on renal function after ischaemia was evaluated in rats subjected to 45 or 90 min warm unilateral renal ischaemia. Two groups of control animals received normal or 3 per cent saline. All solutions were given by bolus injection 3 h before ischaemia. Renal function was significantly protected in animals receiving bicarbonate. Vascular congestion of the inner stripe of the renal medulla was prevented. The survival rate in the group undergoing 90-min ischaemia was 70 per cent for animals receiving bicarbonate and nil in those given saline. Preoperative alkalinization confers significant functional and morphological protection in the ischaemic kidney.
Department of Surgery, Mater Misericordiae Hospital, Dublin, Ireland.
G M
GM
Lennon
P C
PC
Ryan
J M
JM
Fitzpatrick
D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000401:mortality / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D012964:Sodium / Q000008:administration & dosage*; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D017693:Sodium Bicarbonate; D012964:Sodium