[Effects of exercise in the growing stage in mice and of Astragalus membranaceus on immune functions].
A study was carried out to examine the effects of forced running exercise in the growing stage in male ICR mice and of Astragalus membranaceus (As) on their immune functions. The mice were divided at 4 weeks of age into 4 groups. The first group of mice received forced running exercise (E-group), the second group was given As (As-group), the third group received the forced running exercise and was given As (E+As-group) and the fourth group was a control receiving no treatment. The exercise received was forced running at 15 m/min on a flat floor without any slope for 60min a day. The mice of groups E and E+As were exercised 5 times a week for 12 weeks. The mice of groups As and E+As were given As p. o. at 200 mg/kg per day (5 days/week) for 12 weeks. The results obtained were as follows: 1. After 12 weeks of forced running exercise, the weight of the anterior tibialis muscle and succinate dehydrogenase activity in the anterior tibialis muscle increased significantly in groups E and E+As compared with the control group. Thymus weight showed a tendency to increase in groups E and E+As as compared with the control group. 2. The potentiation of the phagocytic function of the reticuloendothelial system examined by the carbon clearance method was seen in groups E, As and E+As. 3. Superoxide anion production of peritoneal macrophages significantly increased in groups As and E+As, but not in group E. 4. The acid phosphatase activity of peritoneal macrophages in groups E, As and E+As significantly increased compared with the control group. 5. Interleukin 1 production by macrophages remained in all groups. 6. The proliferation of splenocytes induced by Con A in groups E, As and E+As significantly increased compared with the control group. These results suggested that forced running exercise in the growing stage in mice and the administration of As enhanced immune functions and that they might also intensify the functioning of the host defense system.
Department of Hygiene, Gifu University School of Medicine.
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Sugiura
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Nishida
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Inaba
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Iwata
D000135:Acid Phosphatase / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D027885:Astragalus propinquus; D001835:Body Weight; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007375:Interleukin-1 / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D009043:Motor Activity / Q000187:drug effects*; D009132:Muscles / Q000201:enzymology; D009929:Organ Size; D010587:Phagocytosis / Q000187:drug effects*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D013481:Superoxides; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase