[Efficacy of xiaoxingzhang guttae ophthalmic eye drops in the treatment of experimental herpes simplex keratitis].
The new guttae ophthalmic Xiaoxingzhang (XXZ) was extracted from Radix Actinidiae, a traditional Chinese herbal drug. The 50% inhibition concentration (IC50) of XXZ on type I Herpes Simplex Virus (HSV-1) in virus cell cultures is 165.48-174.73 micrograms/ml. However, XXZ concentrations greater than 400 micrograms/ml did not cause any microscopically visible disruption of vero cells. The efficacy of XXZ in the treatment of experimental Herpes Simplex Keratitis (HSK) in rabbits is higher than that of idoxuridine. The effective doses of XXZ are not toxic to corneal epithelium. The results suggest that XXZ as a new anti-HSV preparation is potentialy useful in the treatment of patients with HSK.
Zhang
J M
JM
Institute of Molecular Medicine, Zhejiang TCM College, Hangzhou.
Lin
P F
PF
Chen
L L
LL
Tang
L H
LH
Hong
X Q
XQ
Liang
B X
BX
Chen
H S
HS
Teng
L
L
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D003315:Cornea / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005638:Fruit; D016849:Keratitis, Herpetic / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009883:Ophthalmic Solutions; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects / Q000254:growth & development; D010948:Viral Plaque Assay
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D009883:Ophthalmic Solutions; D011134:Polysaccharides