Immunoglobulin binding factor in human seminal plasma: immunological function.
Human seminal plasma contains a protein with an estimated molecular weight of 16 kd that binds serum immunoglobulin gamma (IgG) and is named IgG binding factor (IgBF). Purified IgBF specifically suppressed pokeweed mitogen-induced lymphocyte blastogenesis, having little or no effect on lymphocyte blastogenesis stimulated with phytohemagglutinin or Concanavalin A; antibody-dependent cell-mediated cytotoxicity; natural killer cell activity; or complement-dependent cytotoxicity of antibodies against sperm. It would appear that IgBF may suppress activation of B cells in the male and female genital tract.
Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Japan.
N
N
Maeda
M
M
Kamada
T
T
Daitoh
T
T
Aono
S
S
Futaki
Z G
ZG
Liang
S S
SS
Koide
D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008222:Lymphokines / Q000276:immunology*; D011043:Pokeweed Mitogens / Q000037:antagonists & inhibitors; D029584:Prostatic Secretory Proteins; D012661:Semen / Q000276:immunology*
D008222:Lymphokines; D011043:Pokeweed Mitogens; D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors