New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II.
The synthesis of new halogenated series of 4-anilinoquinoline-3-carboxylic acids, N-[3-carboxyquinolyl(4)]anthranilic acids and their corresponding esters is reported. These have been obtained by reacting 4-chloro-3-carbethoxy-quinolines with variously substituted anilines and methyl anthranilate respectively. The synthesized compounds were tested for antiinflammatory and analgesic activities; some of them showed a good analgesic activity, sometimes higher than that of indomethacin, used as reference drug.
Dipartimento Farmaco Chimico Tecnologico, Università Banchi di Sotto, Siena, Italy.
L
L
Savini
P
P
Massarelli
C
C
Pellerano
G
G
Bruni
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002351:Carrageenan; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011804:Quinolines; D062367:ortho-Aminobenzoates; D002351:Carrageenan; D007213:Indomethacin