Vasoactive properties of a parathyroid hormone-related protein in the rat aorta.
Parathyroid hormone-related protein (PTHrP) or its mRNA transcripts have been documented in a variety of normal tissues, including vascular smooth muscle. A synthetic amino-terminal fragment of PTHrP, PTHrP(1-34), was tested a) for its vasoactive properties in a perfused rat aorta and b) its ability to stimulate cAMP accumulation in cultured rat aorta smooth muscle cells; PTHrP(1-34) was a potent vasodilator and increased cAMP accumulation. The results confirm the potent vasorelaxant properties of PTHrP(1-34), and show that the peptide stimulates adenylate cyclase in vascular smooth muscle cells per se, suggesting, but not proving, linkage of cAMP accumulation to vasorelaxation.
Department of Physiology, Texas Tech University Health Sciences Center, Lubbock 79430.
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Scarpace
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D010281:Parathyroid Hormone / Q000494:pharmacology* / Q000502:physiology; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; C054296:parathyroid hormone-related protein (1-34); D000242:Cyclic AMP