Effects of treatment for childhood cancer on vital organ systems.
Advances in treatment have dramatically increased the survival rate of children and adolescents with cancer. These treatments, however, may be associated with damage to vital organ systems, which may not be evident until many years after the initial diagnosis of cancer and may adversely affect long-term survival and/or the quality of life of former patients. The effects of treatment on three specific organ systems, heart, lungs, and kidneys, are reviewed here.
Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, NY 14263.
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D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects*; D006333:Heart Failure / Q000139:chemically induced; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000528:radiation effects*; D008168:Lung / Q000187:drug effects* / Q000528:radiation effects*; D001743:Urinary Bladder / Q000187:drug effects* / Q000528:radiation effects*; D009396:Wilms Tumor / Q000628:therapy
D000970:Antineoplastic Agents