Phosphorylation of neurotropic alphaherpesvirus envelope glycoproteins: herpes simplex virus type 2 gE2 and pseudorabies virus gI.
I have examined the state of phosphorylation of the envelope glycoproteins of two neurotropic herpesviruses, HSV-2 and PRV. HSV-2 gE2 and PRV gI, which are the homologues to HSV-1 gE, were found to be phosphorylated and phosphoaminoacid analysis revealed that both contained phosphoserine. These findings are consistent with a conserved phosphorylation of the glycoprotein homologues to HSV gE among the neurotropic alphaherpesviruses.
Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.
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Edson
D000595:Amino Acid Sequence; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D011558:Herpesvirus 1, Suid / Q000378:metabolism*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D018139:Simplexvirus / Q000378:metabolism*; D014709:Vero Cells; D014759:Viral Envelope Proteins / Q000378:metabolism*
D014759:Viral Envelope Proteins; C048621:glycoprotein E, herpes simplex-virus type 2; C042966:pseudorabies virus glycoproteins