S-adenosylmethionine metabolism in herpes simplex virus type 2-infected cells.
Infection of primary rat embryo cells with herpes simplex virus type 2 has previously been reported to produce a dramatic and rapid inhibition of cellular DNA methylation. However, it has neither an immediate effect on S-adenosylmethionine breakdown nor on the relative pool sizes of S-adenosylmethionine and S-adenosylhomocysteine.
Seivwright
C
C
Department of Biochemistry, University of Glasgow, U.K.
Macnab
J C
JC
Adams
R L
RL
D000818:Animals; D001711:Biotransformation; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D007700:Kinetics; D008715:Methionine / Q000378:metabolism; D051381:Rats; D012435:S-Adenosylhomocysteine / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000378:metabolism*; D018139:Simplexvirus / Q000502:physiology*; D013462:Sulfur Radioisotopes; D014316:Tritium
D013462:Sulfur Radioisotopes; D014316:Tritium; D012436:S-Adenosylmethionine; D012435:S-Adenosylhomocysteine; D008715:Methionine