[A case report of an advanced esophageal carcinoma treated by neoadjuvant chemotherapy (CDDP + 5-FU) and evaluation of effect on metastatic lymph nodes].
A 69-year-old woman was diagnosed to have type 2 advanced esophageal carcinoma measuring Im 9 cm by X-ray and endoscopic examination. CT scan revealed much swelling of No. 106 and 9 lymph nodes. As the patient had dry cough and these lymph nodes, we tried neoadjuvant chemotherapy for reduction of metastatic lymph nodes. The regimen consisted of CDDP 80 mg/m2 (day 1), 5-FU 800 mg/m2 (day 1-4, continuous). After 2 courses, an operation was performed. Histopathological examination of the section of the primary tumor revealed that only a few cancer cells nests (sq. c.c., mod.) remained in the muscle layer. In 41 dissected lymph nodes, 12 lymph nodes had metastatic cancer cell nests before neoadjuvant chemotherapy and only 4 lymph nodes had a few remaining cancer cells nests. The effect of CDDP + 5-FU therapy is the same for primary tumor and lymph nodes.
First Dept. of Surgery, Kanagawa Cancer Center.
J
J
Minamide
H
H
Koizumi
Y
Y
Ozawa
F
F
Fukano
M
M
Tokunaga
R
R
Moriwaki
S
S
Tamai
Y
Y
Kameda
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis
D002945:Cisplatin; D005472:Fluorouracil