[Determination of the minimal inhibitory concentration of chemotherapeutic drugs with various methods against Mycobacterium avium].
The MIC's were determined for 11 antibiotics by the radiometric method, photometrically with the liquid medium Lockemann and conventionally with Löwenstein-Jensen-medium against Mycobacterium avium complex. Both liquid media (Bactec and Lockemann) agreed, whereas the conventional method gave higher MIC's. Tween 80 should be avoided in all media and diluent fluids, because Tween 80 changes the cell-wall-structure and therefore the minimal inhibition concentrations could be changed. The reporting time for the results was 4 days by the radiometric and 3 weeks by the photometric method.
Medizinische Mikrobiologie, Forschungsinstitut Borstel.
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D003470:Culture Media