Candidicidal activity of the human recombinant myeloperoxidase system.
The effect of the human recombinant myeloperoxidase (recMPO) system on the viability of Candida albicans blastospores was determined. Cells were incubated in the presence of the enzyme, H2O2, and various substrates. In optimal conditions, 100% mortality was reached with only 41 mU of recMPO per ml, confirming its powerful candidicidal activity.
Tournay
C
C
Service de Génétique Appliquée, Université Libre de Bruxelles, Nivelles, Belgium.
Majerus
P
P
Pourtois
M
M
Moguilevsky
N
N
Bollen
A
A
D002176:Candida albicans / Q000187:drug effects*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009195:Peroxidase / Q000235:genetics / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D013172:Spores, Fungal / Q000187:drug effects
D011994:Recombinant Proteins; D006861:Hydrogen Peroxide; D009195:Peroxidase