Experimental vestibular neuritis induced by herpes simplex virus.
An animal model of vestibular neuritis was developed by inoculating herpes simplex virus type 1 (HSV-1) in the auricle of a mouse. Deviation of the body was observed in 4 of 30 mice 6 days after inoculation. These animals were sacrificed 6 to 10 days after inoculation and the vestibular nerve was examined histopathologically and immunohistochemically. The HSV-1 antigens were recognized exclusively in Scarpa's ganglion of the vestibular nerve in 2 of 4 mice in which signs of vestibular involvement were manifested.
Hirata
Y
Y
Department of Otolaryngology, Ehime University School of Medicine, Japan.
Sugita
T
T
Gyo
K
K
Yanagihara
N
N
D000818:Animals; D005455:Fluorescent Antibody Technique; D007839:Functional Laterality / Q000502:physiology; D006561:Herpes Simplex / Q000276:immunology / Q000473:pathology*; D008297:Male; D008575:Meniere Disease / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009443:Neuritis / Q000276:immunology / Q000473:pathology*; D004856:Postural Balance / Q000502:physiology; D018139:Simplexvirus / Q000276:immunology; D014725:Vestibular Nerve / Q000276:immunology / Q000473:pathology*; D000160:Vestibulocochlear Nerve Diseases / Q000276:immunology / Q000473:pathology*; D014779:Virus Replication / Q000276:immunology