The avian rotavirus Ty-1 Vp7 nucleotide and deduced amino acid sequences differ significantly from those of Ch-2 rotavirus.
The Vp7 gene of the avian strain Ty-1, which is classified as G7 serotype, was sequenced and the amino acid sequence deduced. The gene is 1065 nucleotides long with a long open reading frame of 987 nucleotides producing a protein 329 amino acids in length. The amino acid homology of the Ty-1 Vp7 protein to that of the avian Ch-2 Vp7 was 70%. The A, B, and C variable epitope regions of Ty-1 were unique compared to those of Ch-2 and other strains representing the 14G serotypes. The low 53% homology of the A and C regions of Ty-1 and Ch-2 would suggest that Ty-1 may be of a different serotype to the G7 reference strain Ch-2.
Kool
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School of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
Holmes
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D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral; D001483:Base Sequence; D002213:Capsid / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D036022:Capsid Proteins; D004279:DNA, Viral; D006031:Glycosylation; D008969:Molecular Sequence Data; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012703:Serotyping; D014422:Turkeys
D000956:Antigens, Viral; D036022:Capsid Proteins; D004279:DNA, Viral; C050779:VP7 protein, Rotavirus