Gastrointestinal dialysis of digoxin using cholestyramine.
The pharmacokinetic parameters of digoxin given intravenously (0.075 mg/kg) alone and following treatment with oral cholestyramine (8 gm in 50 ml water) were studied in rabbits. Pretreatment with cholestyramine produced a significant decrease in the serum concentration of digoxin and significantly enhances its systemic clearance as indicated by a statistically significant decrease in the area under the concentration-time curve (AUC), half time of elimination (t 1/2), and mean residence time (MRT). These findings indicate that the idea of gastrointestinal dialysis, known with activated charcoal, could be extended to ion-exchange resins that could be a potentially useful adjunctive measure in the management of drug overdose especially with commonly used drugs with a low therapeutic index like digoxin.
Department of Pharmacology, Faculty of Medicine, University of Science & Technology, Irbid, Jordan.
N M
NM
Rawashdeh
H F
HF
al-Hadidi
Y M
YM
Irshaid
A K
AK
Battah
D000284:Administration, Oral; D000818:Animals; D002606:Charcoal; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000494:pharmacology*; D003956:Dialysis; D004064:Digestive System / Q000378:metabolism*; D004077:Digoxin / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits
D002792:Cholestyramine Resin; D002606:Charcoal; D004077:Digoxin