Effect of combined acyclovir and ribavirin on experimental herpes simplex virus type 1 keratoconjunctivitis in rabbits.
The combination of acyclovir and ribavirin has been established to be more effective on experimental herpes simplex keratoconjunctivitis in rabbits than the treatment with individual drugs. The better therapeutic effect of the combination is proved by the decreased severity of the ocular infection and the reduction of the virus shedding in tear film, as well as by the diminished duration of the infection.
Institute of Microbiology, Bulgarian Academy of Sciences.
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S
Pancheva
S
S
Shishkov
D
D
Ilieva
D000212:Acyclovir / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D016849:Keratitis, Herpetic / Q000145:classification / Q000188:drug therapy* / Q000382:microbiology; D007637:Keratoconjunctivitis / Q000145:classification / Q000188:drug therapy* / Q000382:microbiology; D011817:Rabbits; D012254:Ribavirin / Q000627:therapeutic use*; D018139:Simplexvirus / Q000302:isolation & purification; D013666:Tears / Q000382:microbiology; D013997:Time Factors
D012254:Ribavirin; D000212:Acyclovir