[Compounds, similar to acyclovir. VIII. Synthesis and antiviral activity of (R/S)-5-hydroxy-4-hydroxymethyl-3-oxapent-2-yl derivatives of nucleic bases].
The (R/S)-5-hydroxy-4-hydroxymethyl-3-oxapent-2-yl derivatives of the uracil, thymidine, cytosine, adenine, guanine and 1,2,4-triazol-3-carboxamide were synthesized using 1,3-diacetoxy-2-(1-acetoxy)propane and 1,3-dichloro-2-(1-chlorethoxy)propane as alkylating agents. The guanine derivatives exhibited activity against HSV-1 (chemotherapeutic index 32).
Smirnov
I P
IP
Tsilevich
T L
TL
Kochetkova
S V
SV
Vladyko
G V
GV
Korobchenko
L V
LV
Boreko
E I
EI
Gottikh
B P
BP
Florent'ev
V L
VL
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D002642:Chick Embryo; D018139:Simplexvirus
D000998:Antiviral Agents; D000212:Acyclovir