Hydrolysis of some organophosphorus dichlorophenyl esters by hen brain homogenates and rabbit serum compared with hydrolysis of paraoxon.
The hydrolysis of four organophosphorus dichlorophenyl esters and of paraoxon was studied in hen brain homogenates and in rabbit serum. All compounds were hydrolysed by both preparations, but the rates were different in the two preparations. EDTA inhibited the hydrolysis almost completely in rabbit serum, but had only a small effect on the hydrolysis in hen brain homogenates.
Institute for Medical Research and Occupational Health, University of Zagreb, Croatia.
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E
Reiner
M K
MK
Johnson
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M
Jokanović
D000818:Animals; D043303:Aryldialkylphosphatase; D001921:Brain / Q000201:enzymology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000378:metabolism; D002645:Chickens; D005260:Female; D006868:Hydrolysis; D007700:Kinetics; D006899:Mixed Function Oxygenases / Q000097:blood / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000097:blood / Q000378:metabolism*; D010261:Paraoxon / Q000097:blood / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000097:blood / Q000378:metabolism; D011817:Rabbits; D013379:Substrate Specificity
D009943:Organophosphorus Compounds; D006899:Mixed Function Oxygenases; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase; D010261:Paraoxon