Extinction of gene expression in somatic cell hybrids--a reflection of important regulatory mechanisms?
Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell differentiation.
Boshart
M
M
Genecenter, Max Planck Institute for Biochemistry, Martinsried, Germany.
Nitsch
D
D
Schütz
G
G
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; D017868:Cyclic AMP-Dependent Protein Kinases; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology*; D051379:Mice; D011494:Protein Kinases / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000502:physiology
D054756:Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; C517834:PRKAR1A protein, human; C517835:Prkar1a protein, mouse; D011506:Proteins; D011494:Protein Kinases; D017868:Cyclic AMP-Dependent Protein Kinases