Myeloperoxidase deficiency in a patient with rheumatoid arthritis: oxygenation and radical activity by phagocytic cells.
Complete functional deficiency of the phagocytic cell enzyme, myeloperoxidase, is described in a patient with rheumatoid arthritis. Measurement of oxygenation and free radical activity by blood monocytes and polymorphonuclear leucocytes shows gross reduction in myeloperoxidase-dependent chemiluminescence. Implications of these data for theories linking reactive oxygen species to inflammatory tissue damage in rheumatoid arthritis are discussed.
Bell
A L
AL
Department of Medicine (Rheumatology), School of Clinical Medicine, Queen's University, Belfast.
Markey
G M
GM
Alexander
H D
HD
Morris
T C
TC
McMillan
S A
SA
McNally
J A
JA
D000328:Adult; D000911:Antibodies, Monoclonal; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D004789:Enzyme Activation; D005260:Female; D005609:Free Radicals; D006801:Humans; D008163:Luminescent Measurements; D009000:Monocytes / Q000378:metabolism / Q000502:physiology; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000172:deficiency*; D010586:Phagocytes / Q000378:metabolism / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism
D000911:Antibodies, Monoclonal; D005609:Free Radicals; D013481:Superoxides; D009195:Peroxidase