Carbamates of (hydroxyphenoxy)methyl heteroaromatic salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds.
A series of N,N-dimethylcarbamates of 2-[(2'-, 3'-, and 4'-hydroxyphenoxy)methyl] heteroaromatic salts has been prepared. Pyridine, imidazole, quinoline, benzimidazole, and imidazo-[1,2-alpha]pyridine derivatives were included. Most of the compounds are inhibitors of electric eel acetylcholinesterase and also show prophylactic activity toward a 2LD50 dose of soman in mice.
Department of Chemistry, University of Virginia, Charlottesville 22901.
R J
RJ
Sundberg
D
D
Dalvie
J
J
Cordero
M
M
Sabat
H A
HA
Musallam
D000818:Animals; D000931:Antidotes / Q000138:chemical synthesis* / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004557:Electric Organ / Q000201:enzymology; D004593:Electrophorus; D007928:Lethal Dose 50; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology; D012999:Soman / Q000037:antagonists & inhibitors / Q000633:toxicity; D014961:X-Ray Diffraction
D000931:Antidotes; D002219:Carbamates; D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D010636:Phenols; D001285:Atropine; D012999:Soman