[Potentiation of cytotoxicity of anticancer drugs by flavone acetic acid].
We used B 16 melanoma cells both in vitro and in vivo to determine whether Flavone acetic acid (FAA) can increase the cytotoxicity of mitomycin C (MMC) under normothermic and hyperthermic (HT) conditions. The significantly increased cytotoxicity of MMC combined with FAA and HT seems to be mainly related to activation of alkylating species under FAA mediated hypoxic condition.
Cancer Center of Kyushu University.
H
H
Takeuchi
H
H
Baba
S
S
Inutsuka
Y
Y
Sakaguchi
T
T
Kusumoto
H
H
Kusumoto
Y
Y
Maehara
K
K
Sugimachi
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004357:Drug Synergism; D005419:Flavonoids / Q000494:pharmacology*; D006979:Hyperthermia, Induced; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D016685:Mitomycin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005419:Flavonoids; D016685:Mitomycin; C049328:flavone acetic acid