A prospective randomized comparison of zygote intrafallopian transfer and in vitro fertilization-embryo transfer for nontubal factor infertility.
OBJECTIVE
To evaluate the efficacy of zygote intrafallopian transfer (ZIFT) versus standard IVF-ET for the treatment of nontubal factor infertility.


METHODS
A prospective randomized trial.


METHODS
Fifty-nine couples undergoing oocyte retrieval for nontubal infertility in a university hospital-based IVF-ET program.


METHODS
A maximum of four cleaving embryos were transferred into the fallopian tube or uterine cavity 48 or 55 hours after oocyte retrieval, respectively.


METHODS
Rates of implantation, pregnancy, and spontaneous abortion (SAB) were compared.


RESULTS
Clinical pregnancies occurred after 26.5% versus 12% of retrievals and 29% versus 14.3% of transfers in IVF-ET versus ZIFT cycles, respectively. Pregnancy, implantation, and SAB rates did not differ between the groups.


CONCLUSIONS
This prospective randomized trial failed to demonstrate any therapeutic improvement associated with the increased complexity of ZIFT as compared with standard IVF-ET.
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
M R
MR
Fluker
C G
CG
Zouves
M W
MW
Bebbington
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000628:therapy*; D015201:Meta-Analysis as Topic; D011247:Pregnancy; D011446:Prospective Studies; D017388:Zygote Intrafallopian Transfer