Levels of atrial natriuretic factor in the plasma and urine of patients with and without heart failure.
We assayed the concentrations of atrial natriuretic factor and guanosine 3',5'-phosphate in the plasma and urine of six healthy subjects, 12 patients with coronary artery disease and 11 patients with congestive heart failure. Patients with coronary artery disease had normal levels of atrial natriuretic factor in the plasma and urine and a normal excretion of guanosine 3',5'-phosphate, while those with congestive heart failure had a raised level of atrial natriuretic factor in the plasma, an increased excretion of 3',5'-guanosine phosphate and normal excretion of atrial natriuretic factor. Thus, measurement of atrial natriuretic factor in the urine can not replace the assay of the peptide in plasma.
Cattedra di Cardiologia, Universita degli Studi di Brescia, Spedali Civili, Italy.
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Agnoletti
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Panzali
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Ferrari
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000652:urine*; D003327:Coronary Disease / Q000097:blood / Q000652:urine; D006152:Cyclic GMP / Q000097:blood / Q000652:urine; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP