Correction of murine beta-thalassemia by partial bone marrow chimerism: selective advantage of normal erythropoiesis.
beta-Thalassemic mice were transplanted with normal congeneic BM cells after sublethal total body irradiation, which resulted in partial RBC chimerism and correction of anemia. Enumeration of donor-type early hemopoietic progenitor cells (CFU-S) demonstrated that the correction of anemia originated from a minority of normal immature BM cells. It is concluded that successful BMT in beta-thalassemia does not necessarily require ablation of endogenous BM.
van den Bos
C
C
Department of Radiobiology, Erasmus University, Rotterdam, The Netherlands.
Kieboom
D
D
Wagemaker
G
G
D000818:Animals; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000473:pathology; D004920:Erythropoiesis; D005260:Female; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000473:pathology; D007962:Leukocytes / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D011828:Radiation Chimera; D017086:beta-Thalassemia / Q000097:blood / Q000473:pathology / Q000601:surgery*