Changes in plasma copper and zinc during rat development.
The association of copper and zinc to plasma ligands was studied during the rat perinatal period. Analysis was carried out by means of column chromatography (Sephadex G-150) and atomic absorption spectrophotometry. Levels of copper were low at birth and showed a sharp increase after day 10. This increase was similar to that of ceruloplasmin activity as well as its association with copper. Zinc levels, instead, showed higher levels before birth and decreased slowly toward the adult values. Association of zinc to albumin and associated proteins showed a pattern similar to the decrease in plasma zinc levels.
Martínez Lista
E
E
Universitat Rovira i Virgili, Departamento Bioquímica i Biotecnologia, Tarragona, Espanya.
Solé
J
J
Arola
L
L
Mas
A
A
D000375:Aging / Q000097:blood; D000818:Animals; D000831:Animals, Newborn / Q000097:blood* / Q000254:growth & development*; D002570:Ceruloplasmin / Q000032:analysis; D002850:Chromatography, Gel; D003300:Copper / Q000097:blood*; D005314:Embryonic and Fetal Development; D005312:Fetal Blood; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000097:blood*
D003300:Copper; D002570:Ceruloplasmin; D015032:Zinc