Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro.
With Reid's filtration techniques as a bioassay for evaluating red blood cell (RBC) deformability, we purified from Panax pseudo-ginseng an active component that improved the deformability of calcium-loaded RBC. NMR and mass spectrometric studies showed that the purified substance was a triacylglycerol (TG) with linoleic acid as the major fatty acid residue in the esterified positions of glycerol. The mechanism for this TG to improve RBC deformability could be a modification of membrane fluidity rather than a competitive antagonism with calcium ion.
Institute of Traditional Medicine, National Yang-Ming Medical College, Shih-Pai, Taipei, Taiwan.
C Y
CY
Hong
L J
LJ
Lai
S F
SF
Yeh
D004907:Erythrocyte Deformability / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D014280:Triglycerides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D008041:Linoleic Acids; D014280:Triglycerides; D019787:Linoleic Acid