[Acetylsalicylic acid and kurantil in the prevention of pregnancy complications in glomerulonephritis and hypertension].
A controlled clinical trial included 64 pregnant females suffering from chronic glomerulonephritis (CGN) and hypertension: 31 patients received acetylsalicylic acid (ASA) in a dose 125 mg/day and curantyl (150-225 mg/day) from gestation week 12-19 till delivery, 33 control females were not given the drugs. Prenatal care and labour management were similar. Total number of the complications (fetal and natal deaths, preterm labour, intrauterine fetal retardation, late toxicosis, premature detachment of normally located placenta) as well as the number of pregnancies with complications were less in the test group. The same was true for the second pregnancies versus the first ones when ASA and curantyl were not given. It is suggested that low-dose ASA plus curantyl improve placental circulation eventually resulting in less frequent occurrence of pregnancy complications and in better pregnancy outcomes in CGN and hypertensive women.
Rogov
V A
VA
Tareeva
I E
IE
Sidorova
I S
IS
Androsova
S O
SO
Katamadze
K T
KT
Nikiforova
O V
OV
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000704:Analysis of Variance; D001241:Aspirin / Q000008:administration & dosage*; D002908:Chronic Disease; D004176:Dipyridamole / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005921:Glomerulonephritis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors
D004176:Dipyridamole; D001241:Aspirin