Malignant retroperitoneal paraganglioma with intranuclear vacuoles in a fine needle aspirate. A case report.
The cytologic findings in fine needle aspiration smears and cell blocks from a malignant retroperitoneal paraganglioma with subsequent histologic confirmation are described. The aspirate contained clusters of cells with ill-defined borders, often varied in size, round or oval nuclei and marked anisokaryosis. An unusual feature was the presence of prominent intranuclear vacuoles in some cells. The histologic and ultrastructural findings, as well as the results of histochemical and immunodiagnostic staining, are also presented.
Department of Pathology, San Jorge General Hospital, Huesca, Spain.
J
J
Vera-Alvarez
M
M
Marigil-Gómez
M
M
Abascal-Agorreta
J
J
Vázquez-Garcia
D000230:Adenocarcinoma / Q000473:pathology; D007516:Adenoma, Islet Cell / Q000473:pathology; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002864:Chromogranins / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010235:Paraganglioma / Q000473:pathology* / Q000648:ultrastructure; D012186:Retroperitoneal Neoplasms / Q000473:pathology* / Q000648:ultrastructure
D002864:Chromogranins