Synthesis, antibacterial and antifungal activity of metal (II) complexes of 2-acetylpyridine thiosemicarbazones.
2-Acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(2- methylthiosemicarbazone) and their metal (II) complexes have been synthesized and characterized by chemical and spectral methods. They were studied for their antibacterial, antifungal and amoebicidal activity in vitro and for their toxicity in vivo. The ligands and their metal (II) complexes exhibited significant activity against a wide spectrum of microorganisms. The metal (II) complexes derived from 2-acetylpyridine-(4-methylthiosemicarbazone) seem to be the most active compounds.
Department of Chemistry, University of Calabar, Nigeria.
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Offiong
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Martelli
D000563:Amebicides / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D004748:Entamoeba histolytica / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000563:Amebicides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D009942:Organometallic Compounds; D013882:Thiosemicarbazones