[Anorexia in a pony with Cushing's disease].
An eighteen-year-old pony gelding was referred to the Faculty of Veterinary Medicine because of colic, due to cecal tympany. His haircoat was dull with long wavy hair. After medical treatment of the colic it was sent home three days later. Just before it had been dismissed the morning plasma glucose concentration measured 10.2 mmol.l-1. The basal plasma cortisol concentration was high (180 nmol.l1) and basal plasma ACTH concentration was highly elevated (> 960 pg.ml1). An ACTH-stimulation test was performed by intravenous administering of 0.25 mg synthetic ACTH 1 24 at 9.00 hours showing adrenocortical hyperfunction by an increase of plasma cortisol to 771 nmol.l-1. After 365 days the gelding was readmitted because of anorexia since two days, due to a mandibula fracture without obvious signs of osteoporosis. This time the morning plasma glucose concentration measured 11.9 mmol.l-1. Euthanasia was carried out and at necropsy both a mandibula fracture and a pituitary pars intermedia adenoma were found.
Vakgroep Inwendige Ziekten en Voeding der Grote Huisdieren, Faculteit Diergeneeskunde, Utrecht.
J H
JH
van der Kolk
C J
CJ
van Hoorn
E
E
van Garderen
A J
AJ
van den Belt
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000855:Anorexia / Q000209:etiology / Q000662:veterinary*; D003480:Cushing Syndrome / Q000097:blood / Q000662:veterinary*; D006734:Horse Diseases / Q000097:blood*; D006736:Horses; D008297:Male; D008337:Mandibular Fractures / Q000150:complications / Q000662:veterinary
D000324:Adrenocorticotropic Hormone