CRK proto-oncogene maps to human chromosome band 17p13.
A genomic DNA fragment, isolated from a human phage library using a chicken crk cDNA probe, was shown to derive from the human CRK locus. We have used fluorescent in situ hybridization (FISH) to map CRK distal in chromosome band 17p13, a region which demonstrates frequent deletion or loss of heterozygosity in a wide range of human cancers.
Department of Pathology, Childrens Hospital of Los Angeles, CA 90027.
T
T
Fioretos
N
N
Heisterkamp
J
J
Groffen
S
S
Benjes
C
C
Morris
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D015342:DNA Probes; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes / Q000235:genetics*
D015342:DNA Probes; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas