Parasol (P alpha) ganglion-cells of the primate fovea: immunocytochemical staining with antibodies against GABAA-receptors.
Retinae of macaque monkeys were immuno-stained with antibodies against GABAA-receptors. In peripheral retina most ganglion cells were immunoreactive. In central retina, around the fovea, staining in the ganglion cell layer was selective and only 5-8% of all ganglion cells were labelled: these had the largest cell bodies and their dendrites occupied a broad stratum in the middle of the inner plexiform layer. From comparison with Golgi-stained ganglion cells it is concluded that the entire population of parasol (P alpha)-cells at the fovea was labelled. The mosaic and sampling properties of parasol cells were determined by combining dendritic field measurements of Golgi-stained cells with their density when immuno-stained. There is convergence of 30-50 cones onto each foveal parasol ganglion cell. The dendritic fields of both ON- and OFF-parasol cells provide complete retinal coverage. The Nyquist limits of their mosaics are 4 min of arc.
Max-Planck-Institut für Hirnforschung, Frankfurt/Main, Germany.
U
U
Grünert
U
U
Greferath
B B
BB
Boycott
H
H
Wässle
D000818:Animals; D003712:Dendrites / Q000648:ultrastructure; D005584:Fovea Centralis / Q000166:cytology / Q000294:innervation*; D005724:Ganglia / Q000737:chemistry*; D008252:Macaca fascicularis; D008297:Male; D011963:Receptors, GABA-A / Q000032:analysis* / Q000276:immunology; D012160:Retina / Q000737:chemistry / Q000166:cytology
D011963:Receptors, GABA-A