Cutaneous anaplastic T-cell lymphoma in a patient with human immunodeficiency virus infection: detection of Epstein-Barr virus DNA.
The Epstein-Barr virus (EBV) genome exists in tumour cells of T-cell lymphomas in non-immunosuppressed patients. We identified EBV-DNA by in situ hybridization in a case of anaplastic T-cell lymphoma associated with acquired immunodeficiency syndrome (AIDS). EBV-DNA has been reported in AIDS-related Hodgkin's disease or B-cell lymphoma, but never in T-cell lymphoma. Although our results suggest that EBV could play a role in the development of these anaplastic T-cell lymphomas, the mechanism of EBV penetration into T-cells remains uncertain.
Department of Dermatology, Hôtel Dieu, Nantes, France.
B
B
Dreno
B
B
Milpied-Homsi
P
P
Moreau
B
B
Bureau
P
P
Litoux
D004279:DNA, Viral / Q000032:analysis*; D015658:HIV Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000382:microbiology
D004279:DNA, Viral