The prevalence of type 1 diabetes mellitus at follow-up of Swedish infants congenitally infected with cytomegalovirus.
In a Swedish prospective study of congenital cytomegalovirus (CMV) infection, 76 infants were shown to be infected among 16,474 newborns screened by virus isolation in urine. Seventy-three of the excreters were followed up and one developed Type 1 diabetes, as compared to 38 of the 19,483 children born during the same period (p = 0.14, Fisher's one-tailed test). Thus we found no evidence that the combined finding of congenital CMV infection and Type 1 diabetes mellitus was related.
Department of Paediatrics, University of Lund, Malmö General Hospital, Sweden.
S A
SA
Ivarsson
B
B
Lindberg
K O
KO
Nilsson
K
K
Ahlfors
L
L
Svanberg
D001323:Autoantibodies / Q000097:blood; D002096:C-Peptide / Q000097:blood; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000453:epidemiology* / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D005500:Follow-Up Studies; D005934:Glucagon; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D015995:Prevalence; D013548:Sweden / Q000453:epidemiology
D001323:Autoantibodies; D002096:C-Peptide; C024211:islet cell antibody; D005934:Glucagon