The oxazolidinone antibacterial agent DuP 105 does not act on cell wall biosynthesis or on a beta-lactamase.
(S)-3-(4-Methylsulfinylphenyl)-5-(acetamidomethyl)oxazolidinone (DuP 105; 1, R = CH3SO, R' = Ac), one of a new class of antibacterial agents, is shown to be devoid of inactivation and inhibitory properties toward bacterial cell wall biosynthesis and toward a beta-lactamase. This is consistent with the idea that this class of compounds acts by a route different from that of the beta-lactam antibiotics.
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113.
R B
RB
Silverman
N
N
Tran
R K
RK
Sinha
F C
FC
Neuhaus
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001409:Bacillus cereus / Q000201:enzymology*; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010080:Oxazoles / Q000494:pharmacology*; D010457:Peptidoglycan / Q000096:biosynthesis; D013289:Streptococcaceae / Q000187:drug effects / Q000378:metabolism*; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010080:Oxazoles; D010457:Peptidoglycan; C054753:4-methylsulfinylphenyloxooxazolidinylmethylacetamide; D001618:beta-Lactamases