Screening for the APP codon 670/671 mutations in Alzheimer's disease.
A mutation at codons 670 and 671 of exon 16 of the amyloid precursor protein has recently been identified as a cause of early onset familial Alzheimer's disease. Using restriction enzyme digestion, screening failed to reveal the occurrence of this mutation in 43 families with early onset, 31 families with late onset, 30 cases of sporadic Alzheimer's disease or 30 clinically normal individuals.
Department of Biochemistry, St. Mary's Hospital Medical School, Paddington, London, UK.
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Houlden
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Crawford
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Rossor
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Mullan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D001483:Base Sequence; D003062:Codon / Q000235:genetics*; D004262:DNA Restriction Enzymes; D005091:Exons / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D016133:Polymerase Chain Reaction
D016564:Amyloid beta-Protein Precursor; D003062:Codon; D004262:DNA Restriction Enzymes