Tetanization during GABAA receptor activation induces long-term depression in visual cortex slices.
In rat visual cortex slices, long-term depression of synaptic transmission was induced by tetanic stimulation to white matter during bath-application of the GABAA agonist muscimol. This result supports the view that a combination of presynaptic activity and postsynaptic inhibition leads to a depression of synaptic efficiency.
Department of Integrative Brain Science, Faculty of Medicine, Kyoto University, Japan.
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Kato
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Yoshimura
D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*
D011963:Receptors, GABA-A; D009118:Muscimol