Immune responses to varicella zoster virus infections in healthy children.
The immune responses to varicella zoster virus were studied in 67 otherwise normal children participating in a placebo-controlled trial of acyclovir for the treatment of chickenpox. No differences were observed between acyclovir and placebo groups. Children were studied longitudinally, at onset of chickenpox, and at 1 month, 3 months, 1 year, and 3 years after infection. These data help define the natural history of the immune response to chickenpox in children.
Rotbart
H A
HA
Department of Pediatrics (Section of Infectious Diseases), University of Colorado School of Medicine, Denver 80262.
Levin
M J
MJ
Hayward
A R
AR
D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002644:Chickenpox / Q000188:drug therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D007371:Interferon-gamma; D000212:Acyclovir