Improvement of pregnancy rates with oocyte donation in older recipients with the addition of progesterone vaginal suppositories.
Pregnancy rates and implantation rates with oocyte donation in recipients 40 years of age and older were significantly lower than those obtained in recipients under the age of 40. This difference was eliminated when P vaginal suppositories were added to the luteal regimen in older recipients. Our experience suggests that uterine aging may play a role in the successful initiation of a pregnancy, but this may be overcome with the preparation of the uterus with P vaginal suppositories.
Center for Reproductive Medicine, San Ramon Regional Medical Center, San Ramon, California.
L N
LN
Weckstein
A
A
Jacobson
D
D
Galen
K
K
Hampton
K
K
Ivani
J
J
Andres
D000328:Adult; D000375:Aging / Q000502:physiology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology / Q000628:therapy; D008597:Menstrual Cycle; D008875:Middle Aged; D009865:Oocytes; D010570:Pessaries; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000627:therapeutic use; D014019:Tissue Donors
D011374:Progesterone