Enkephalin antisense peptides: design, synthesis, and biological activity.
The antisense mRNA complementary to the sense strand of Metenkephalin encodes the antisense peptides, His-Glu-Ala-Pro-Ile (compound 88/62). The antisense peptide and its (Gln1)-analogue (compound 88/63) have synergestic effects on the opioid activity of Met-enkephalin in the GPI test system.
Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
P K
PK
Misra
W
W
Haq
S B
SB
Katti
K B
KB
Mathur
R
R
Raghubir
G K
GK
Patnaik
B N
BN
Dhawan
D000595:Amino Acid Sequence; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001483:Base Sequence; D015195:Drug Design; D004744:Enkephalin, Methionine / Q000378:metabolism / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016372:RNA, Antisense / Q000235:genetics*; D011957:Receptors, Opioid / Q000378:metabolism*
D000700:Analgesics; D009842:Oligopeptides; D016372:RNA, Antisense; D011957:Receptors, Opioid; C082043:histidyl-glutamyl-alanyl-prolyl-isoleucine; C082044:glutaminyl-glutamyl-alanyl-prolyl-isoleucine; D004744:Enkephalin, Methionine