[Therapeutic trials for promotion of faecal excretion of PCDFs by the administration of rice bran fiber and cholestyramine in Yusho patients].
It is well-known that Yusho disease was caused by polychlorinated dibenzofurans (PCDFs), and that 2, 3, 4, 7, 8-Pentachlorodibenzofuran (PnCDF), 1, 2, 3, 4, 7, 8- and 1, 2, 3, 6, 7, 8-Hexachlorodibenzofurans (HxCDFs) still retain in the patient bodies. As patients usually suffer from various chronic syndrome, an effective treatment is extremely needed. In order to assess the rice bran fiber (RBF) and cholestyramine on stimulating faecal excretion of PCDFs, two clinical trials were carried out in 1990 and 1991. In the first trial in 1990, 10 g of RBF (dietary fiber content was 50%) and 4 g of cholestyramine were administered to four Yusho patients three times a day for a week. The stool from patients were collected a week before and during the administration. These were pooled respectively, and then two samples for measurement. In the second trial in 1991, 10 g of dietary fiber rich RBF (refined-RBF, dietary fiber content was 85%) and 4 g of cholestyramine were administered to four Yusho patients three times a day for two weeks. In this trial, three stool samples were obtained from each patient, ie., a week before administration, and first and second week during administration. Level of PCDFs was determined by high resorption GC/MS and the following results were obtained. 1) In the first trial (1990) the faecal excretion of PnCDF and HxCDFs increased at the rates of 42-88% and 7-47%, respectively, in three out of four patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Iida
T
T
Fukuoka Institute of Health and Environmental Sciences.
Hirakawa
H
H
Matsueda
T
T
Nakagawa
R
R
Morita
K
K
Tokiwa
H
H
Tsuji
H
H
Nakayama
J
J
Hori
Y
Y
D001572:Benzofurans / Q000493:pharmacokinetics* / Q000506:poisoning*; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000627:therapeutic use*; D000072338:Dibenzofurans, Polychlorinated; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use*; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012275:Oryza; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000506:poisoning
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004043:Dietary Fiber; D002792:Cholestyramine Resin; D011078:Polychlorinated Biphenyls