Pathologic characterization of a renin-secreting juxtaglomerular cell tumor in a child and review of the pediatric literature.
We describe a rare case of renal hypertension in a 15-year-old caused by juxtaglomerular cell tumor and compare our findings with those of 20 children reported in the literature. These tumors are usually encapsulated and composed microscopically of polyhedral cells with bland nuclei separated by fibrovascular septa. Characteristic renin granules can be demonstrated by Bowie's stain or electron microscopy. These tumors are benign. Pathologists should recognize the morphologic characteristics of these tumors when dealing with renin-producing neoplasia.
New York Medical College, Valhalla.
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RK
Abbi
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M
McVicar
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S
Teichberg
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L
Fish
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E
Kahn
D000293:Adolescent; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology*; D007606:Juxtaglomerular Apparatus / Q000473:pathology*; D007680:Kidney Neoplasms / Q000150:complications / Q000201:enzymology / Q000473:pathology*; D008854:Microscopy, Electron; D012083:Renin / Q000097:blood*
D012083:Renin