[The interaction of angiotensin with lipid monolayers].
The studies of lipid monolayers showed the interaction of an angiotensin-2 and lipid monolayers to be a two-stage process. In the first stage peptide molecules were adsorbed due to electrical interaction in the plane of polar heads of lipid molecules. In the second stage peptide molecules incorporated into the lipid matrix owing to hydrophobic interactions. These results suggest that the lipid matrix may perform the function of a catalyst of the peptide-receptor interaction by changing the spatial structure of angiotensin molecules at the transition of the latter from hydrophobic environment.
Rybal'chenko
V K
VK
Gevod
V S
VS
Reshetniak
I L
IL
Shamonina
A M
AM
D000804:Angiotensin II / Q000378:metabolism*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008074:Lipoproteins / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D011485:Protein Binding; D013329:Structure-Activity Relationship; D013997:Time Factors
D008074:Lipoproteins; D008563:Membrane Lipids; D000804:Angiotensin II