Acute cholestatic hepatitis with rash and hypereosinophilia associated with ranitidine treatment.
We report a case of acute cholestatic hepatitis associated with rash and hypereosinophilia, in which the absence of transfusion, intercurrent viral infection, alcohol consumption or other hepatotoxic drugs are suggestive of ranitidine-induced hepatotoxicity. The pathogenesis of the disorder is unknown, but the lack of a dose-effect relationship, the rarity and unpredictability of the reaction, as well as the clinical signs suggest that hypersensitivity is involved. Physicians should be aware of this rare and idiosyncratic side-effect of ranitidine.
Devuyst
O
O
Dépt. de Médecine Interne, Cliniques Universitaires St. Luc, Faculté de Médecine de l'U.C.L., Bruxelles.
Lefebvre
C
C
Geubel
A
A
Coche
E
E
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced; D004342:Drug Hypersensitivity / Q000150:complications; D004802:Eosinophilia / Q000139:chemically induced*; D005076:Exanthema / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000009:adverse effects*
D011899:Ranitidine