Graphic-aided study of metabolic modifications of plasma in cancer using proton magnetic resonance spectroscopy.
Proton high-resolution MRS of human plasma allows the rapid detection, on the same spectrum, of many compounds originating from different metabolic pathways. In this paper, we illustrate the modifications of the plasma metabolic profiles recorded by proton NMR spectroscopy in different classes of cancers. These modifications can be easily monitored with graphic aids such as 'star plots' which define for each type of cancer a particular pattern describing the most altered metabolic pathways. By using 'star plots' three types of metabolic patterns have been distinguished: (i) the 'inflammatory' pattern characterized by an increase of glycosylated moieties of glycoproteins; (ii) a 'lipid modified' pattern, characterized by various modifications occurring mainly in the lipid moieties detected by MRS; and (iii) a pattern which is often observed in sarcomas and mainly characterized by an alteration in the N-acetyl glucosamine/N-acetyl neuraminic acid ratio. This study demonstrates the ability of proton MRS of plasma to rapidly detect the occurrence of metabolic modifications brought about by cancer evolution or therapy.
Centre de Résonance Magnétique Biologique et Médicale, (URA CNRS 1186), Faculté de Médecine, Marseille, France.
J
J
Vion-Dury
R
R
Favre
M
M
Sciaky
M
M
Kriat
S
S
Confort-Gouny
J R
JR
Harlé
N
N
Grazziani
P
P
Viout
F
F
Grisoli
P J
PJ
Cozzone
D000117:Acetylglucosamine / Q000097:blood; D006258:Head and Neck Neoplasms / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009369:Neoplasms / Q000097:blood* / Q000145:classification; D011522:Protons; D012680:Sensitivity and Specificity; D012794:Sialic Acids / Q000097:blood; D012878:Skin Neoplasms / Q000097:blood; D013057:Spectrum Analysis / Q000379:methods
D008055:Lipids; D011522:Protons; D012794:Sialic Acids; D000117:Acetylglucosamine