Synthesis and pharmacological properties of N-(4-substituted-1-piperazinylalkyl)-1-butyl-2,5-dimethylpyrrole-3,4- dicarboxyimide derivatives.
The preparation of a number of N-(4-substituted-1-piperazinylalkyl)-1-butyl-2,5-dimethylpyrrol e-3,4- dicarboxyimides (3) is described. The structures of the novel compounds were confirmed by elemental and spectral analyses. The results of a preliminary pharmacological study of CNS effects caused by compounds 3 are reported.
Department of Pharmacy, Medical Academy in Wroclaw, Poland.
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Malinka
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Tatarczyńska
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001058:Apomorphine / Q000037:antagonists & inhibitors; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005334:Fever / Q000139:chemically induced; D006380:Helplessness, Learned; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000037:antagonists & inhibitors; D017366:Serotonin Receptor Agonists / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000927:Anticonvulsants; D002491:Central Nervous System Agents; D010879:Piperazines; D011758:Pyrroles; D017366:Serotonin Receptor Agonists; D012110:Reserpine; D001058:Apomorphine; C015068:1-(3-chlorophenyl)piperazine; D010433:Pentylenetetrazole