Interaction of Mycoplasma arthritidis superantigen with human T cells.
To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the V beta 17 gene segment; however, other V beta may also be used and not all V beta 17+ TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive V beta sequences suggests that MAM does not interact with a single site encoded by a V beta segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site.
Posnett
D N
DN
Department of Medicine, Cornell University Medical College, New York, New York 10021.
Hodtsev
A S
AS
Kabak
S
S
Friedman
S M
SM
Cole
B C
BC
Bhardwaj
N
N
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens; D000942:Antigens, Bacterial; D001665:Binding Sites / Q000235:genetics; D002460:Cell Line; D017124:Conserved Sequence; D006801:Humans; D051379:Mice; D008934:Mitogens / Q000276:immunology*; D008969:Molecular Sequence Data; D009174:Mycoplasma / Q000276:immunology*; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment; D018089:Superantigens; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000942:Antigens, Bacterial; D008934:Mitogens; C052996:Mycoplasma arthritidis mitogen; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens