Neutralizing antibody to vesicular stomatitis virus (HTLV-I) pseudotype in infants born to seropositive mothers.
Breast feeding is the major route of mother-to-child transmission of human T-cell leukemia virus type I (HTLV-I). Our experiments with rabbits have shown that passive immunization is capable of blocking cell-to-cell infection of HTLV-I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV-I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3-6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV-I remains to be studied.
Department of Medicine, Kochi Medical School.
Y
Y
Iwahara
T
T
Sawada
H
H
Taguchi
H
H
Hoshino
M
M
Umemoto
H
H
Take
S
S
Foung
I
I
Miyoshi
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis*; D015490:HTLV-I Infections / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D009500:Neutralization Tests; D012698:Serologic Tests; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology*; D014758:Viral Core Proteins / Q000276:immunology; D015678:Viral Structural Proteins / Q000276:immunology
D000914:Antibodies, Viral; D015481:HTLV-I Antibodies; D014758:Viral Core Proteins; D015678:Viral Structural Proteins