Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms.
Analysis of variola virus nucleotide sequence revealed proteins belonging to several families which provide the virus with the possibility of overcoming the barriers of specific and non-specific host defence against viral infection. The complement-binding proteins, lymphokine-binding proteins, and serine protease inhibitors can be assigned to this type, as can the proteins providing the orthopoxviruses with resistance to interferon. The revealed differences between the genes (proteins) of variola and vaccinia viruses under study are discussed.
Institute of Molecular Biology NPO Vector, Koltsovo, Novosibirsk region, Russian Federation.
S N
SN
Shchelkunov
V M
VM
Blinov
L S
LS
Sandakhchiev
D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics; D003165:Complement System Proteins / Q000378:metabolism; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D017471:Receptors, Interferon / Q000737:chemistry / Q000235:genetics; D017472:Receptors, Interleukin-1 / Q000737:chemistry / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry / Q000235:genetics; D014616:Vaccinia virus / Q000737:chemistry / Q000235:genetics*; D012901:Variola virus / Q000737:chemistry / Q000235:genetics*; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics; D014777:Virus Diseases / Q000276:immunology / Q000382:microbiology
D002352:Carrier Proteins; D017471:Receptors, Interferon; D017472:Receptors, Interleukin-1; D015842:Serine Proteinase Inhibitors; D014409:Tumor Necrosis Factor-alpha; D014764:Viral Proteins; D003165:Complement System Proteins