Factors that modulate inescapable shock-induced reductions in daily activity in the rat.
Most behavioral and neurochemical changes produced by inescapable shock dissipate in 1-3 days. However, daily running activity is depressed for 14-42 days following one to three sessions of inescapable shock. In the present experiments, we sought to determine whether factors known to be important in the development of the short-term effects of exposure to inescapable shock would also be important in the production of the long-term effect of inescapable shock on daily activity. Three factors were examined: a) the escapability of the shock; short-term behavioral changes generally do not occur if the shock is escapable; b) naltrexone pretreatment; the opioid antagonist naltrexone typically prevents many of the short-term behavioral sequelae of inescapable shock; c) treatment with the anxiogenic beta-carboline FG-7142; administration of this compound alone frequently mimics inescapable shock in its ability to transiently disrupt behavior. The inescapable shock-induced reduction in daily activity did not depend upon escapability of the stressor. In addition, naltrexone did not prevent and FG-7142 did not induce the reduction in daily activity associated with stressor exposure.
Department of Psychology, University of Colorado, Boulder 80309.
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WW
Woodmansee
L H
LH
Silbert
S F
SF
Maier
D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000523:psychology; D001923:Brain Chemistry / Q000187:drug effects; D002243:Carbolines / Q000494:pharmacology; D004597:Electroshock; D006380:Helplessness, Learned; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009271:Naltrexone / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000187:drug effects; D013315:Stress, Psychological / Q000503:physiopathology
D002243:Carbolines; D011963:Receptors, GABA-A; D009271:Naltrexone; C035874:FG 7142