[Nuclear state splitting: a working model for the mechanochemical coupling of differentiation "waves" with the controlling genes (master genes)].
The cell state splitter (CSS) model for differentiation, supported by recent evidence, requires that an intracellular mechanical events result in a commitment signal to the nucleus that determines which of two readied gene cascades is to be activated, via their master genes. We show how a link between the mechanochemistry of cell state splitting and the molecular genetics of "nuclear state splitting" might be forged out of well known molecular components of cells.
Bjorklund
N K
NK
University of Manitoba, Winnipeg, Canada.
Gordon
R
R
D000818:Animals; D005075:Biological Evolution; D001696:Biomechanical Phenomena; D015220:Calcium Channels / Q000502:physiology; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004817:Epidermis / Q000196:embryology; D005775:Gastrula / Q000648:ultrastructure; D005796:Genes; D005809:Genes, Regulator; D008954:Models, Biological; D015398:Signal Transduction
D015220:Calcium Channels