Recovery of the extensor digitorum longus muscle in the rat following L4 nerve sectioning.
The purpose of this study was to define the time course and the extent of recovery of muscle weight and tension in the extensor digitorum longus (EDL) muscle following partial denervation in nine-week-old male rats (300 to 325 g). The L4 nerve underwent unilateral sectioning while the opposite side served as a sham-operated control. The muscle weight and tension of the control and the partially denervated group were examined at two (n = 15), eight (n = 15), 12 (n = 15), and 16 (n = 15) weeks after L4 nerve sectioning. The partially denervated muscle weights as a percentage of respective controls were 58.6%, 56.1%, 68.4%, and 61.9% at two, eight, 12, and 16 weeks after L4 nerve sectioning. There was no significant difference (p > 0.05) between these percentages at the respective time intervals. The tetanic tensions compared with their respective matched controls were 14.5%, 32.8%, 50.0%, and 32.4% at these respective time intervals (p < 0.05). The muscle weight (MW) and muscle weight/body weight (MW/BW) of the partially denervated side as a percentage of its contralateral control remained unchanged throughout the duration of the experiment. The twitch tension (Pt), tetanic tension (Po), Pt/Po, and the Po/MW of the partially denervated muscle relative to its matched control increased between the second and the eighth week post-partial denervation (p < 0.05). After the eighth week post-L4 nerve sectioning, there was no further increase in these parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Rehabilitation Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
G P
GP
Gutierrez
G J
GJ
Herbison
P
P
Vega
J
J
Nasuti
E
E
Cook
W
W
Conlan
D000818:Animals; D001835:Body Weight; D008297:Male; D009119:Muscle Contraction; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation*; D009416:Nerve Regeneration; D051381:Rats; D017207:Rats, Sprague-Dawley; D013127:Spinal Nerves / Q000502:physiology*