Synthesis and biological activity of bromolignans and cyclolignans.
Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows anti-viral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.
Department of Organic Chemistry, University of Salamanca, Faculty of Pharmacy, Spain.
A
A
San Feliciano
M
M
Medarde
R
R
Pelaez Lamamie de Clairac
J L
JL
López
P
P
Puebla
M D
MD
García Gravalos
P
P
Ruiz Lázaro
M T
MT
García de Quesada
D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005493:Folic Acid Antagonists; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D017705:Lignans; D008031:Lignin / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy
D058892:Adenosine Deaminase Inhibitors; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D017705:Lignans; D008031:Lignin; D005982:Glutathione Transferase