Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.
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Chiueh
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Miyake
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Peng
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism*; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D007501:Iron / Q000502:physiology; D008995:Monoamine Oxidase / Q000502:physiology; D009410:Nerve Degeneration / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology; D010084:Oxidation-Reduction; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000503:physiopathology; D011188:Potassium / Q000502:physiology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects* / Q000503:physiopathology
D015220:Calcium Channels; D005609:Free Radicals; D006878:Hydroxides; D015221:Potassium Channels; D017665:Hydroxyl Radical; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D007501:Iron; D008995:Monoamine Oxidase; D011188:Potassium; D002118:Calcium; D004298:Dopamine