Clastogenicity of chlorambucil to the mouse bone marrow: consideration in relation to its genetic specificity of action in some assays.
The human carcinogen and mouse germ cell mutagen chlorambucil is reported here to give a strong positive response in the mouse bone marrow micronucleus assay (4 mg/kg; single intraperitoneal injection). An increased incidence of micronucleated bone marrow white cells was also observed. It is concluded that chlorambucil is a broad spectrum mutagen that possesses subtle and specific mutagenic activities in some assay systems.
Ashby
J
J
ZENECA Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Tinwell
H
H
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002699:Chlorambucil / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests / Q000379:methods*; D009153:Mutagens / Q000494:pharmacology*
D009153:Mutagens; D002699:Chlorambucil