Thyroid nodular hyperplasia: chromosomal studies in 14 cases.
Cytogenetic study of 14 thyroid nodular hyperplasias revealed a hyperdiploid karyotype in two cases (14%) and a normal chromosomal complement in the remaining cases. Some of the numerical alterations found were identical to the ones considered characteristic of a subset of thyroid adenomas (+5, +7, +9, +12, +14, and +16). Our findings suggest that the cytogenetic events involved in the pathogenesis of thyroid hyperplastic lesions and benign tumors may be closely related, which supports the hypothesis of a biologic "continuum" between these two types of lesions.
Institute for Molecular Pathology and Immunology, University of Porto--IPATIMUP, Portugal.
L
L
Roque
P
P
Gomes
C
C
Correia
P
P
Soares
J
J
Soares
S
S
Castedo
D000328:Adult; D000368:Aged; D046508:Culture Techniques; D005260:Female; D006044:Goiter, Nodular / Q000235:genetics* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007621:Karyotyping; D008297:Male; D008875:Middle Aged