A familial/genetic study of plasma serine and glycine concentrations.
Plasma serine and glycine concentrations were assayed in a sample of 28 nuclear families (n = 108). Complex segregation analysis of these familial data reveals significant genetic control of concentrations via a single major gene locus. The serine and glycine metabolizing enzyme serine hydroxymethyltransferase (SHMT) is suggested as the most likely candidate for this single major gene locus.
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
E J
EJ
Devor
R
R
Waziri
D004298:Dopamine / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005998:Glycine / Q000097:blood* / Q000235:genetics; D006801:Humans; D007389:Internal-External Control; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D011618:Psychotic Disorders / Q000097:blood / Q000235:genetics*; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics; D012694:Serine / Q000097:blood*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D012694:Serine; D005680:gamma-Aminobutyric Acid; D005947:Glucose; D005998:Glycine; D004298:Dopamine