Chlorpromazine and paraquat poisoning.
The effects of chlorpromazine hydrochloride (CPZ) on paraquat (PQ) poisoning were examined using male and female beagle dogs. Twenty-six dogs were divided into 3 groups of 21 PQ-poisoned dogs and a control group of 5 saline-treated dogs. Thirty minutes after the 21 dogs were given 20 mg PQ dichloride/kg body weight sc, groups of 7 dogs received 3 mg CPZ/kg im, 5 mg CPZ/kg im or 0.5 ml saline/kg im daily for 5 d. PQ-treated dogs exhibited dyspnea. Serum angiotensin I converting enzyme (AICE) activity of the PQ-treated dogs was elevated during days 1-3. Lung AICE activity of the PQ-treated dogs was slightly lower than the control group. Lung hydroxyproline content was not elevated in either dying or surviving dogs. Based on our biochemical evaluations, PQ-induced pulmonary fibrosis did not occur during the 24 d of this study. From days 2-12 post-PQ dosing, all the dogs in the PQ + CPZ (3 mg/kg) group died. Dogs in the PQ + CPZ (5 mg/kg) group and the PQ + saline group had 6/7 and 5/7, respectively, die from days 2-24. The survival rate of the PQ + CPZ-treated dogs was not prolonged when compared to the PQ + saline group. The expected CPZ-induced increased in survival times, concurrent reductions in mortality rates, and effects on serum and lung AICE activities were not observed.
Department of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Y
Y
Yamada
F
F
Akahori
T
T
Masaoka
M
M
Sirai
K
K
Kohzaki
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002570:Ceruloplasmin / Q000187:drug effects; D002746:Chlorpromazine / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D005353:Fibronectins / Q000187:drug effects; D006909:Hydroxyproline / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010269:Paraquat / Q000037:antagonists & inhibitors* / Q000506:poisoning; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects
D000931:Antidotes; D005353:Fibronectins; D002570:Ceruloplasmin; D007703:Peptidyl-Dipeptidase A; D010269:Paraquat; D006909:Hydroxyproline; D002746:Chlorpromazine