GABAB receptors in the lung.
gamma-Aminobutyric acid (GABA), an important inhibitory neurotransmitter in the mammalian CNS, is also found in peripheral tissues, including the lung. Recent pharmacological studies using selective ligands for GABAA and GABAB receptors demonstrate that of these two, the GABAB receptor is the important receptor subtype controlling lung functions. GABAB agonists inhibit a variety of responses in the airways, including neuronally induced cholinergic- and tachykinin-mediated smooth muscle contraction, microvascular leakage, anaphylactic bronchospasm and cough. Because these conditions are seen in certain respiratory diseases, such as asthma, a selective GABAB agonist may have therapeutic potential for the treatment of this respiratory disorder.
Chapman
R W
RW
Schering-Plough Research Institutes, Kennleworth, NJ 07033.
Hey
J A
JA
Rizzo
C A
CA
Bolser
D C
DC
D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D003371:Cough / Q000188:drug therapy; D006801:Humans; D008168:Lung / Q000737:chemistry* / Q000294:innervation / Q000378:metabolism; D009475:Neurons, Afferent / Q000737:chemistry / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000187:drug effects; D011963:Receptors, GABA-A / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D015320:Tachykinins / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use
D011963:Receptors, GABA-A; D015320:Tachykinins; D005680:gamma-Aminobutyric Acid; D001418:Baclofen