The hand-foot-genital syndrome: on the variable expression in affected males.
In this report we document male-to-male transmission in the hand-foot-genital syndrome. An affected father transmitted the syndrome to his three sons. A grade IV hypospadias, which was the most severe genital anomaly in affected males, was present in the youngest, moderately mentally retarded microcephalic male sibling.
Centre for Human Genetics, University of Leuven, Belgium.
J P
JP
Fryns
A
A
Vogels
P
P
Decock
H
H
van den Berghe
D000015:Abnormalities, Multiple / Q000235:genetics*; D005532:Foot Deformities, Congenital / Q000235:genetics*; D006228:Hand Deformities, Congenital / Q000235:genetics*; D006801:Humans; D007021:Hypospadias / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D013577:Syndrome