Accelerated maximal velocity of the red blood cell Na+/K+ pump in hyperlipidemia is related to increase in 1-palmitoyl,2-arachidonoyl-plasmalogen phosphatidylethanolamine.
Among several phospholipid classes and molecular species of phosphatidylcholine and phosphatidylethanolamine (PE) analyzed, only the percentage of the molecular species 1-palmitoyl,2-arachidonoyl (16: 0/20: 4)-plasmalogen-(alkenylacyl)-PE showed positive relations to the maximal activity and to the dissociation constant of the red blood cell Na+/K+ pump for Na+ in normo- and hyperlipidemic donors. A preferential interaction of this molecular species with the Na+/K+ pump is proposed.
Physiologisches Institut, Universität München, Germany.
J
J
Duhm
B
B
Engelmann
U M
UM
Schönthier
S
S
Streich
D000328:Adult; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010955:Plasmalogens / Q000737:chemistry / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010955:Plasmalogens; C081892:1-palmitoyl-2-arachidonoyl plasmalogen phosphatidylethanolamine; D000254:Sodium-Potassium-Exchanging ATPase