Anastomosis of uterine serosa with cyanoacrylate versus suture in rats.
Experimental end-to-end uterine horn anastomosis was performed in 20 Wistar rats with the conventional technique of microsurgery, with n-butyl-cyanoacrylate and with cyanoacrylate with the addition of one or two microsutures. Only in the case of conventional anastomosis and of cyanoacrylate in combination with two microsutures, was the patency rate 100%, whereas in the case of uterine horns anastomosed with cyanoacrylate alone, the patency rate was 80%. Histologic findings revealed the presence of tissue adhesive encysted in the serosa with a moderate inflammatory reaction around it, remaining two months after surgery. On the 60th day, the muscularis layer was only continuous in the conventional and cyanoacrylate with two microsutures groups. Our findings indicate that tissue adhesive and two sutures used together may offer a viable alternative to sutures for genital duct anastomosis.
Department of Animal Pathology, University of Zaragoza, Spain.
J M
JM
Caballero-Gómez
J
J
Ortega-Moreno
D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D004659:Enbucrilate; D005069:Evaluation Studies as Topic; D005260:Female; D007249:Inflammation / Q000209:etiology; D008866:Microsurgery; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013537:Sutures; D000267:Tissue Adhesions / Q000209:etiology; D014591:Uterine Diseases / Q000209:etiology / Q000473:pathology; D014599:Uterus / Q000473:pathology / Q000601:surgery*
D004659:Enbucrilate