Serum collagenase-like peptidase activity correlated with bone mineral density. A study of 102 elderly women.
To clarify the relationship between collagenase-like peptidase (CL-peptidase) and bone metabolism, serum CL-peptidase activity and bone mineral density (BMD) in the lumbar spine, measured by dual energy X-ray absorptiometry (DEXA), were determined in 102 women with a mean age of 70 (41-94) years. The serum activity of CL-peptidase increased slightly with age up to the 8th decade, and then decreased. Next, we classified the subjects into the following 2 groups by age: a postmenopausal group 50-69 years, and an elderly group over 70 years. In the younger group serum CL-peptidase activity did not correlate with BMD, while in the elderly it did. Our result suggests that serum CL-peptidase activity may reflect bone resorption in elderly women.
Department of Orthopedics, Chubu National Hospital, Obu, Japan.
H
H
Ueda
A
A
Harada
R
R
Katoh
M
M
Hagihara
T
T
Miura
H
H
Iwata
T
T
Nagatsu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D001862:Bone Resorption / Q000201:enzymology; D005260:Female; D006801:Humans; D003012:Microbial Collagenase / Q000097:blood*; D008875:Middle Aged
D003012:Microbial Collagenase