[Trans-activating function of integrated hepatitis B virus].
HBV DNAs are often found in integrated form in human hepatocellular carcinoma (HCC). Since transactivation of the X gene has been shown, surveys of collections of HBV integrants with flanking cellular sequence were performed to clarify whether they might exhibit a transactivation. The majority of integrants showed transactivation effect which may to be due to the virus-cell fusion products derived from the 3' truncated X gene. Additionally, it has been found that 3' truncated preS2/S gene in the integrant encodes a transactivator to which C terminal truncation is essential. These results suggest that the transactivating effect of integrated HBV DNAs plays a role in hepatocarcinogenesis by activating cellular genes.
Ikeda municipal Hospital.
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H
Nakatake
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S
Yamamoto
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K
Matsubara
D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics; D004279:DNA, Viral; D005786:Gene Expression Regulation; D005814:Genes, Viral / Q000235:genetics*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics; D015533:Transcriptional Activation; D016662:Virus Integration
D004279:DNA, Viral