Uteroplacental and fetal circulation during extradural bupivacaine-adrenaline and bupivacaine for caesarean section in hypertensive pregnancies with chronic fetal asphyxia.
We have studied the effects of an extradural block during Caesarean section using either bupivacaine plain or with adrenaline 85-100 micrograms on blood velocity waveforms of maternal uterine and placental arcuate arteries and fetal umbilical, renal and middle cerebral arteries, in 20 hypertensive parturients with chronic fetal asphyxia. Fetal myocardial function was investigated at the same time by M-mode echocardiography. Extradural anaesthesia resulted in a significant decrease in maternal mean systolic and diastolic arterial pressures in both groups, but this was more marked after plain bupivacaine. There were no significant differences in any of the Doppler recordings relative to baseline values after plain bupivacaine, but after bupivacaine with adrenaline there were significantly increased blood flow velocity indices for the maternal uterine and placental arcuate arteries and significantly decreased indices in the fetal renal and middle cerebral arteries. Neonatal outcome as evaluated by Apgar scores and acid-base values in the umbilical cord were similar in the two groups. The results suggest that adrenaline added to the solution of bupivacaine increased vascular resistance in the uteroplacental circulation, indicating impaired blood flow.
Department of Anaesthesiology, University of Oulu, Finland.
S
S
Alahuhta
J
J
Räsänen
P
P
Jouppila
R
R
Jouppila
A I
AI
Hollmén
D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000494:pharmacology; D002585:Cesarean Section; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology; D005333:Fetus / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D011673:Pulsatile Flow / Q000187:drug effects; D014599:Uterus / Q000098:blood supply; D014655:Vascular Resistance / Q000187:drug effects
D002045:Bupivacaine; D004837:Epinephrine