Epidermal growth factor receptor activity and clinical outcome in glioblastoma and meningioma.
Epidermal growth factor receptor (EGF-r) activity in patients with glioblastoma multiforme (GBM: n = 27) and meningioma (n = 18) was compared with clinical outcome. All patients with GBM were followed up to time of death. In patients with GBM there was no significant relationship between EGF-r activity and either patient survival time or age. EGF-r activity in patients with meningioma was neither related to age nor, at a median of 40 months after surgery, to clinical outcome. These results suggest that routine estimation of EGF-r activity in these intracranial tumours is not indicated.
Department of Clinical Neurosciences, Western General Hospital, Edinburgh, Scotland.
N L
NL
Dorward
R A
RA
Hawkins
I R
IR
Whittle
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D015996:Survival Rate
D066246:ErbB Receptors