[Evaluation of biodistribution and imaging of atherosclerotic lesions using 111In-labeled low-density lipoprotein].
111In-labeled low-density lipoprotein (LDL) was administered to Watanabe heritable hyperlipidemic rabbits (WHHL group) and control rabbits (control group) to evaluate its biodistribution and scintigraphic images by gamma-camera and radioactivity of each organ. With external imaging, the heart, liver, kidney, bone and spleen of each rabbit were observed. By setting the region of interest, the liver/heart ratio of the WHHL group was significantly lower than that of the control group (p < 0.05), the plasma half life of LDL was longer and radioactivity in blood, heart and aorta was higher in the WHHL group. Each aorta was autoradiographed and significant accumulation of 111In-labeled-LDL was recognized in the aortic arch, bifurcation of intercostal and celiac artery in the WHHL group. By the use of labeled LDL with the combination of gamma-camera, it is capable of detecting the regulation of lipoprotein metabolism and imaging atherosclerotic lesions externally.
First Department of Internal Medicine, Toho University School of Medicine, Tokyo.
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Yamashina
D000818:Animals; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D001345:Autoradiography; D015902:Gamma Cameras; D007204:Indium / Q000493:pharmacokinetics; D008077:Lipoproteins, LDL / Q000378:metabolism*; D011817:Rabbits; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D008077:Lipoproteins, LDL; D007204:Indium