[Interaction of NAD with the GABA-ergic system of the rat brain].
After administration of corazole content of gamma-aminobutyric acid (GABA) was increased in the rat brain within 2 min and 10 min by 28% and 80%, respectively. Content of the GABA was distinctly decreased in the prespastic phase. During this period specific binding of 3H-muscimol to the GABA receptors was decreased. NAD at concentrations 10(-6) M and 10(-7) M activated the GABA receptors and inhibited binding of 14C-GABA to the synaptosomes of both intact rats and the animals treated with the convulsant agent. NAD appears to cause an effect as an inhibitory neurotransmitter at the postsynaptic level.
Fomenko
A I
AI
Parkhomets
P K
PK
Donchenko
G V
GV
Stepanenko
S P
SP
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D009118:Muscimol / Q000378:metabolism; D009243:NAD / Q000378:metabolism* / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000032:analysis; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000737:chemistry / Q000378:metabolism*
D011963:Receptors, GABA-A; D009243:NAD; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D010433:Pentylenetetrazole