Molecular alterations in a patient with Turcot's syndrome.
Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.
Rochlitz
C F
CF
Department Innere Medizin, Kantonsspital Basel.
Heide
I
I
de Kant
E
E
Neubauer
A
A
Schmidt
C A
CA
Neuhaus
P
P
Huhn
D
D
Herrmann
R
R
D000230:Adenocarcinoma / Q000235:genetics; D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000293:Adolescent; D001254:Astrocytoma / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D009154:Mutation; D017354:Point Mutation; D012878:Skin Neoplasms / Q000556:secondary; D013577:Syndrome