[The regulation of the nuclear RNA polymerase activity of the liver and brain in rats of different ages by a cytoplasmic modulator of thyroxine action].
The effect of physiological, concentration of thyroxine and cytoplasm thyroxine-binding protein (thyroxine action modulator, TAM4) on the RNA-polymerase activity in rat liver and bain cells in ontogenesis was studied. The physiological doses of the hormone were shown not to effect the RNA-polymerase of isolated liver and brain nuclei, while TAM4 caused the stimulation of enzymatic activity in these organs. ++TAM4 stimulating effect in liver correlated with increasing animal age, while the maximum RNA-polymerase activation by tAM was discovered in young rats under one month-At later stage the RNA-polymerase activity was same as in the controls. In is suggested that the cytoplasmic hormone-binding proteins take part in the formation of liver and brain sensitivity to the action of the thyroid gland hormones.
Turakulov
Ia Kh
IaKh
Dalimova
S N
SN
Kamalieva
I R
IR
Umarova
G D
GD
Atakhanova
B A
BA
D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology*; D003593:Cytoplasm / Q000187:drug effects / Q000201:enzymology*; D012321:DNA-Directed RNA Polymerases / Q000187:drug effects* / Q000378:metabolism; D004622:Embryo, Mammalian; D005260:Female; D006980:Hyperthyroidism / Q000139:chemically induced / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology; D013975:Thyroxine-Binding Proteins / Q000494:pharmacology*
D013975:Thyroxine-Binding Proteins; D012321:DNA-Directed RNA Polymerases; D013974:Thyroxine