Once-daily azithromycin in the treatment of adult skin and skin-structure infections.
The aim of this prospective, blinded, randomized study was to demonstrate the efficacy and safety of oral azithromycin and dicloxacillin in the treatment of adults with acute skin and skin-structure infections. Sixty-two patients were included in the intent-to-treat group and 60 were evaluable for analysis. Azithromycin was given as a 500 mg once-daily dose for three days and dicloxacillin as 250 mg qid for seven days. Isolated pathogens included primarily Staphylococcus aureus, Streptococcus spp., and coagulase-negative staphylococci. Clinical resolution was 83.3% in the azithromycin group and 83.9% in the dicloxacillin group, with bacteriological eradication of 90.0% in the azithromycin group and 87.1% in the dicloxacillin group. Persistence of infection was recorded in one patient in the dicloxacillin group and superinfection in one patient in the azithromycin group. Azithromycin appears to be a safe and effective antibiotic for the treatment of adult patients with acute skin and skin-structure infections.
Infectious Diseases Division, Hospital Civil de Guadalajara, Jalisco, México.
G
G
Amaya-Tapia
G
G
Aguirre-Avalos
J
J
Andrade-Villanueva
G
G
Peredo-González
R
R
Morfín-Otero
S
S
Esparza-Ahumada
E
E
Rodríguez-Noriega
D000038:Abscess / Q000188:drug therapy / Q000382:microbiology; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017963:Azithromycin; D004009:Dicloxacillin / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004917:Erythromycin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus; D013291:Streptococcus
D004917:Erythromycin; D017963:Azithromycin; D004009:Dicloxacillin