Role of converting enzyme inhibitors in the treatment of heart failure.
Treatment with angiotensin-converting enzyme inhibitors has proved to be effective in relieving symptoms of congestive heart failure. With recognition of the high mortality rate that accompanies heart failure, the question has arisen whether angiotensin-converting enzyme inhibitors may also improve survival. Early trials of the vasodilator combination hydralazine plus nitrates (V-HeFT trial) showed a strong trend toward a reduction in mortality, and a subsequent trial of the angiotensin-converting enzyme inhibitor enalapril in a population of patients with end-stage heart failure (CONSENSUS trial) showed a highly significant reduction in the mortality. The SOLVD trial was begun in 1986 to determine whether enalapril could reduce morbidity and mortality in patients with mild to moderate congestive failure (primarily New York Heart Association classes II and III), as well as in asymptomatic patients with a low ejection fraction. This report presents the results in patients with symptoms of congestive failure who were studied in the SOLVD treatment trial. A total of 2,569 patients were recruited into the trial, with an average follow-up period of 41.4 months. There was a 16% reduction in mortality in the enalapril-treated group compared with that of patients receiving placebo (p = 0.0036), as well as a 26% reduction in the combined end point of death plus hospital admission for congestive failure (p < 0.0001). Compared with placebo, enalapril significantly reduced the incidence of death due to progressive heart failure but apparently had no effect on sudden death. The results clearly indicate that the angiotensin-converting enzyme inhibitor enalapril can reduce both morbidity and mortality in symptomatic congestive heart failure.(ABSTRACT TRUNCATED AT 250 WORDS)
University of Rochester Medical Center, New York 14642.
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Hood
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D015337:Multicenter Studies as Topic; D016277:Ventricular Function, Left / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors