The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus.
We have investigated the expression of the mRNAs for brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) in the hippocampus before and after induction of long term potentiation (LTP) of synaptic transmission in the dentate gyrus through stimulation of the perforant path (PP). A unilateral PP stimulation produced a bilateral increase in the mRNA for both BDNF and NGF in granular neurones of the dentate gyrus but not in other neurones in the hippocampus. The mRNA for neurotrophin-3 (NT-3) was bilaterally decreased by LTP but that of NT-4 remained at the basal level. These results suggest that individual neurotrophic factors may play different roles in neuronal plasticity.
Department of Neurochemistry, Max Planck Institute for Psychiatry, Martinsried, Germany.
E
E
Castrén
M
M
Pitkänen
J
J
Sirviö
A
A
Parsadanian
D
D
Lindholm
H
H
Thoenen
P J
PJ
Riekkinen
D000818:Animals; D015152:Blotting, Northern; D019208:Brain-Derived Neurotrophic Factor; D004558:Electric Stimulation; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D017403:In Situ Hybridization; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D020933:Neurotrophin 3; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020933:Neurotrophin 3; D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases; C073922:neurotrophin 4