An investigation into the effects of chloroquine on fertility of male rats.
We investigated the effect of chloroquine on the fertility of adult male rats. Rats were administered chloroquine at a daily intra-peritoneal dose of 10mg/kg body weight and 40mg/kg body weight per rat, five days a week for 16 weeks. Females mated with treated males showed a dose dependent decrease in the number of litter per female rat. In the in-vitro studies, more than 80% os spermatozoa were immotile in all concentrations of chloroquine tested. These results suggest that chloroquine brings about its antifertility effect by decreasing sperm motility.
Okanlawon
A O
AO
Department of Anatomy, College of Medicine, University of Lagos, Nigeria.
Noronha
C C
CC
Ashiru
O A
OA
D000818:Animals; D001835:Body Weight; D002738:Chloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005298:Fertility / Q000187:drug effects*; D007248:Infertility, Male / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008098:Litter Size / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013081:Sperm Motility / Q000187:drug effects*
D002738:Chloroquine