Electroencephalographic effects of flucloxacillin in rats.
The neurotoxicity of flucloxacillin, an isoxazolyl derivative of beta-lactamic antibiotics, was studied in rats by electroencephalographic recordings. The results show that intravenous flucloxacillin, (200 mg/kg) produced cortical activity modifications. The changes in electroencephalogram consist of irritative activity patterns and bursts of high voltage waves with spikes and polyspikes. The effects of other beta-lactamic drugs (cloxacillin, ampicillin-sulbactam and penicillin G) on electroencephalography activity were also investigated after intravenous administration of equivalent doses. These drugs did not change the normal bioelectric cerebral activity of the rats.
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of Chile, Santiago.
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D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003023:Cloxacillin / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects*; D005436:Floxacillin / Q000494:pharmacology*; D007275:Injections, Intravenous; D010400:Penicillin G / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013407:Sulbactam / Q000494:pharmacology
D005436:Floxacillin; C035444:sultamicillin; D000667:Ampicillin; D003023:Cloxacillin; D010400:Penicillin G; D013407:Sulbactam