The effect of dietary fiber on apolipoprotein A-I and A-IV gene expression in rat intestine.
The effect of the dietary fiber on apo A-I and apo A-IV mRNA levels was studied in the intestine of rats fed either by fiber-free or high-fiber diets. Rats fed high-fiber diet had lower plasma cholesterol concentrations than animals fed fiber-free diet. A proximal-distal apo A-I and apo A-IV mRNA gradient was found in both groups. High-fiber diet feeding reduced apo A-I mRNA levels in jejunum and ileum and ileal apo A-IV mRNA levels as compared to fiber-free diet fed rats. The obtained results suggest that some dietary fibers may play a role in regulation of lipoprotein metabolism in the intestine, including apolipoprotein synthesis.
Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique, St. Genès Champanelle, France.
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Felgines
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Mazur
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Rémésy
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Rayssiguier
D000818:Animals; D016632:Apolipoprotein A-I / Q000096:biosynthesis* / Q000235:genetics; D001054:Apolipoproteins A / Q000096:biosynthesis* / Q000235:genetics; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D004043:Dietary Fiber; D012333:RNA, Messenger; C022205:apolipoprotein A-IV; D002784:Cholesterol