Epstein-Barr virus and CD30+ malignant lymphomas.
Phenotypic, genotypic, and karyotypic analyses have indicated that Hodgkin's disease and CD30+ anaplastic large cell lymphoma may be conceived as malignancies derived from activated, cytokine-producing lymphoid cells, in many instances with an immature genotype. Most recently, Epstein-Barr virus (EBV) genomes and gene products, most notably the transformation-associated latent membrane protein (LMP), have been detected in approximately 50 and 20% of the cases, respectively. These findings suggest that EBV may superimpose an activated phenotype on an immature lymphoid cell, contributing to the pathoetiology of sizable proportions of these CD30+ malignancies.
Institute of Pathology, Klinikum Steglitz, Free University Berlin, Germany.
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D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D002869:Chromosome Aberrations; D016207:Cytokines / Q000235:genetics; D005260:Female; D015870:Gene Expression; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007621:Karyotyping; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D008297:Male; D009857:Oncogenes; D011519:Proto-Oncogenes; D011946:Receptors, Antigen / Q000235:genetics
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D016207:Cytokines; D017730:Ki-1 Antigen; D011946:Receptors, Antigen