EBER-1 expression in thymic carcinoma.
The Epstein-Barr virus-encoded small nuclear RNA, EBER-1, has been shown to be a suitable target for the in situ hybridization detection of EBV in routinely processed tissue specimens. We evaluated the presence of EBV in thymic carcinoma and invasive thymoma using EBER-1 in situ hybridization on formalin-fixed paraffin-embedded tissue sections. EBER-1 expression was demonstrated in a case of lymphoepithelioma-like thymic carcinoma, but was not detectable in other thymic carcinomas including six squamous cell carcinomas, a clear cell carcinoma and seven invasive thymomas. As reported in three previous cases of EBV-associated thymic carcinoma, lymphoepithelioma-like thymic carcinoma was shown to be closely associated with EBV in our series.
Department of Pathology, Jichi Medical School, Tochigi, Japan.
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T
Fujii
T
T
Kawai
K
K
Saito
K
K
Fukushima
T
T
Hasegawa
M
M
Tokunaga
T
T
Yokoyama
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000382:microbiology* / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D016601:RNA-Binding Proteins / Q000032:analysis*; D012269:Ribosomal Proteins; D013945:Thymoma / Q000737:chemistry / Q000382:microbiology*; D013953:Thymus Neoplasms / Q000737:chemistry / Q000382:microbiology* / Q000473:pathology
D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human