Ifosfamide-induced hyperpigmentation.
BACKGROUND
Pigmented banding of the nails and hyperpigmentation of hands and feet may occur during cyclophosphamide therapy. Ifosfamide, an analogue of cyclophosphamide, might be expected to cause similar pigmentary changes, but, to the knowledge of the authors, there are no reports of this.


METHODS
The authors describe skin pigment changes in a 5-year-old patient receiving ifosfamide, MESNA, and etoposide for the treatment of relapsed Wilms tumor.


RESULTS
A review of the literature concerning cyclophosphamide-induced pigmentary changes is presented, along with a discussion of the possible correlation of renal dysfunction with pigmentary changes.


CONCLUSIONS
This case should alert health care providers to this uncommon adverse effect of ifosfamide.
Division of Clinical/Hospital Pharmacy, University of Iowa College of Pharmacy, Iowa City 52242-1123.
M E
ME
Teresi
D J
DJ
Murry
A S
AS
Cornelius
D002675:Child, Preschool; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D015080:Mesna / Q000008:administration & dosage; D010859:Pigmentation Disorders / Q000139:chemically induced*; D009396:Wilms Tumor / Q000188:drug therapy*
D005047:Etoposide; D015080:Mesna; D007069:Ifosfamide