[Clinical value of the various methods of ACTH determination].
We determined 293 plasma-ACTH levels out of 49 patients. In 12 patients with various pituitary diseases 168 samples were collected during a standardized pituitary stimulation test. For this purpose we used the following kits: the DYNOtest ACTH and LUMItest ACTH and Allegro HS-ACTH test. Additionally, morning ACTH levels were analyzed from 49 patients using Allegro HS ACTH test and DYNOtest ACTH. Regarding ACTH concentrations during pituitary stimulation the clinical usefulness of the 3 named tests were comparable. Pair differences of morning ACTH levels were not statistically significant. In a setting of a wide range of ACTH levels all 3 trials proved appropriate for making a diagnosis. Practicability of all 3 tests was similar. For all 3 methods incubation can be done overnight which saves time. Reagents can be reused when frozen immediately after reconstitution.
Abteilung Endokrinologie/Nuklearmedizin, Medizinischen Universitätsklinik Graz.
S
S
Ramschak-Schwarzer
R
R
Lipp
A
A
Passath
H
H
Warnkross
C
C
Stiegler-Heinz
H
H
Dobnig
T
T
Wascher
G
G
Leb
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D015592:Immunoradiometric Assay; D010900:Pituitary Diseases / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D010901:Pituitary Function Tests; D010911:Pituitary Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests; D011863:Radioimmunoassay; D011933:Reagent Kits, Diagnostic; D012016:Reference Values
D011933:Reagent Kits, Diagnostic; D000324:Adrenocorticotropic Hormone