Trisomy 4 with double minute chromosomes in acute nonlymphocytic leukemia.
We report on three further cases of trisomy 4 in acute nonlymphocytic leukemia. In one case the trisomy 4 was accompanied by double minute (dmin) chromosomes. Of the 34 reports of trisomy 4, dmin were also found in five cases, showing a clear nonrandom association between the two cytogenetic abnormalities.
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, United Kingdom.
P W
PW
Thompson
J A
JA
Whittaker
H
H
Brennan
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002869:Chromosome Aberrations; D002894:Chromosomes, Human, Pair 4; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D014314:Trisomy