Cytomegalovirus seroprevalence in women bearing children in Jefferson County, Kentucky.
Symptomatic congenital cytomegalovirus (CMV) disease occurs almost exclusively in infants born to seronegative mothers who acquire the virus during pregnancy. This study sought to determine patterns of CMV immunity in women of childbearing age at one center participating in a national study. Cord blood specimens from 100 consecutive deliveries at each of three hospitals were tested for CMV-specific IgG. Mean age of women in this sample was 25.7 years; 76% were white, 60% were from middle and upper socioeconomic status, 64% were married, and 57% had other living children. Overall seroprevalence rate was 62%. Univariate analysis showed strong associations between seropositivity and lower socioeconomic status, non-white race, and age younger than 25 years (odds ratios, 4.4, 3.9, and 2.5, respectively). Stratification by socioeconomic status and race eliminated the effect of age. Stratification by socioeconomic status markedly reduced the effect of race, whereas stratification by race only moderately reduced the effect of lower socioeconomic status, which was the strongest predictor of seropositivity (odds ratio, 3.4). Seroprevalence was lowest among older white women of middle and upper socioeconomic status (47% seropositive). Development of longitudinal regional seroprevalence data will facilitate interpretation of data generated by the National CMV Registry.
Division of Pediatric Infectious Diseases, University of Louisville School of Medicine, KY 40292.
G S
GS
Marshall
G P
GP
Rabalais
J A
JA
Stewart
J G
JG
Dobbins
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D005260:Female; D005312:Fetal Blood / Q000382:microbiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007629:Kentucky / Q000453:epidemiology; D010865:Pilot Projects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G