A new bastadin from the sponge Psammaplysilla purpurea.
A new bastadin 2 and the previously reported bastadins 5 [3], 7 [4], and 12 (formerly bastadin 9) [5] were isolated from the Verongid sponge Psammaplysilla purpurea collected in Pohnpei. Compound 2 is mildly cytotoxic against several cell lines and inhibits the enzymes topoisomerase II and dehydrofolate reductase.
Department of Chemistry, University of Hawaii, Honolulu 96822.
J R
JR
Carney
P J
PJ
Scheuer
M
M
Kelly-Borges
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002470:Cell Survival / Q000187:drug effects; D005493:Folic Acid Antagonists; D055768:Halogenated Diphenyl Ethers; D000882:Haplorhini; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D055768:Halogenated Diphenyl Ethers; D010456:Peptides, Cyclic; D010647:Phenyl Ethers; D059005:Topoisomerase II Inhibitors; C080231:bastadin 14