Effect of aspirin on mitochondrial lipids in experimental myocardial infarction in rats.
The effect of aspirin (0.45 mg/100 g body wt, orally for 60 days) on mitochondrial lipids induced by isoproterenol (200 mg/Kg body wt, Sc for 2 days) was studied in rats. In isoproterenol treated rats, marked increases in cholesterol, free fatty acids, triglycerides and lipid peroxides in heart mitochondria were observed. The phospholipid level was lowered with a significant increase in the activity of phospholipase. The activity of Na+K(+)-ATPase registered a decrease and the activity of Ca(2+)-ATPase increased in isoproterenol treatment. Aspirin treatment is found to counteract the effect of isoproterenol on lipid and lipid peroxide formation and associated enzyme changes in heart mitochondria.
Manjula
T S
TS
Department of Biochemistry, University of Madras, India.
Devi
C S
CS
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D007545:Isoproterenol / Q000633:toxicity; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D009203:Myocardial Infarction / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol; D001241:Aspirin