Post-kala-azar dermal leishmaniasis: a clinical and therapeutic study.
BACKGROUND
Post-kala-azar dermal leishmaniasis is a condition peculiarly confined to the Indian subcontinent.


METHODS
The clinical features and investigations in 18 patients of post-kala-azar dermal leishmaniasis were studied.


RESULTS
There was a polymorphic picture from hypopigmented macules to nodules and plaques. Mucous membranes were affected in five, the lips and glans penis being the most frequent sites. Histopathologically, a rich dermal infiltrate was seen in indurated lesions and in macules; it was confined to perivascular foci in the upper dermis. Leishman-Donovan bodies were seen in 16.


CONCLUSIONS
The lesions cleared in 4 to 5 months after treatment with sodium antimony gluconate intramuscularly 20 mg/kg/day up to a maximum of 1 g/day. The drug was well tolerated.
Department of Dermatology and Leprology, Safdarjang Hospital, New Delhi, India.
V
V
Ramesh
R S
RS
Misra
U
U
Saxena
A
A
Mukherjee
D000293:Adolescent; D000328:Adult; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D001706:Biopsy; D002648:Child; D003955:Diagnostic Tests, Routine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D007898:Leishmaniasis, Visceral / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*
D000967:Antimony Sodium Gluconate