A recently recognized entity associated with the treatment of acute promyelocytic leukemia: the retinoic acid syndrome.
All-trans-retinoic acid is an effective induction treatment for acute promyelocytic leukemia. Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome". We describe this syndrome, which occurred in one of our patients and was successfully treated by the administration of dexamethasone.
Department of Pathologic Physiology, Athens University School of Medicine, Laiko General Hospital, Greece.
T
T
Marinakis
C A
CA
Papadimitriou
C
C
Koufos
A
A
Fertakis
D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000188:drug therapy*; D007958:Leukocyte Count; D008297:Male; D012074:Remission Induction; D013577:Syndrome; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D014212:Tretinoin; D003907:Dexamethasone