Cisplatin-resistant metastatic hepatoblastoma: complete response to carboplatin, etoposide, and liver transplantation.
A child with stage 4 hepatoblastoma failed to respond to treatment with cisplatin and adriamycin. She then showed a response to carboplatin with complete clearing of pulmonary metastases. Bilobar liver disease persisted, although significantly reduced in size. A liver transplant was subsequently performed and she remains in complete remission 36 months later. After the first course of carboplatin, there was a dramatic rise in alpha-feto protein which then fell exponentially. Carboplatin warrants further study in hepatoblastoma.
Department of Paediatric Oncology, St. James's University Hospital, Leeds, England.
L
L
Lockwood
D
D
Heney
G R
GR
Giles
I J
IJ
Lewis
C C
CC
Bailey
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000556:secondary / Q000628:therapy*; D002945:Cisplatin / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004351:Drug Resistance; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000628:therapy*; D016031:Liver Transplantation; D008175:Lung Neoplasms / Q000556:secondary; D012074:Remission Induction
D005047:Etoposide; D016190:Carboplatin; D002945:Cisplatin