Chronic barbiturate treatment increases NMDA receptors but decreases kainate receptors in mouse cortex.
Chronic phenobarbital effects on brain NMDA and kainate receptors were assessed using [3H]MK-801 and [3H]kainate. Mice fed a phenobarbital diet for 7 days had a higher density of MK-801 binding sites (NMDA receptors) but a lower density of kainate receptors in cortex than control mice. No changes in MK-801 or kainate binding were observed in hippocampus. The results suggest brain area specific adaptation of certain glutamate receptors to chronic barbiturate treatment.
Department of Pharmacology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
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D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000378:metabolism / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010634:Phenobarbital / Q000494:pharmacology*; D017470:Receptors, Glutamate / Q000187:drug effects*; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*
D016291:Dizocilpine Maleate; D010634:Phenobarbital; D017470:Receptors, Glutamate; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate