Chromosome 17 allele loss in hepatocellular carcinoma but not in synchronous liver adenoma.
A 51-year-old female underwent resection of two synchronous liver tumours, a hepatocellular carcinoma and an adenoma. DNA analysis revealed allele loss on chromosome 17 (17p13, near the locus of p53 tumour suppressor gene) in the hepatocellular carcinoma but not in the adenoma. This finding may support the view that loss of p53 tumour suppressor gene is associated with tumour progression.
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
S F
SF
Ding
R P
RP
Jalleh
J
J
Dooley
C B
CB
Wood
N A
NA
Habib
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics*