The influence of dose and ethnic origins on the pharmacokinetics of nifedipine.
The pharmacokinetics of nifedipine capsules was investigated in healthy young Caucasian and South Asian subjects. Both the area under the plasma concentration-time curve (AUC) and terminal half-life of nifedipine were significantly higher in South Asians compared with Caucasian subjects after single oral doses of 10 and 20 mg. The AUC and half-life values of the nitropyridine metabolite were also higher in South Asians than in Caucasian subjects. The serum protein binding of nifedipine was similar in the two groups. The pharmacokinetics were essentially linear in both Caucasian subjects (0 to 30 mg; n = 27) and South Asians (0 to 20 mg; n = 16). There was no indication of a separate subgroup of Caucasian subjects with high AUC values equivalent to the poor metabolizers reported previously. Pharmacodynamic modeling for South Asians gave estimates comparable to those previously reported in Caucasian subjects. Patients of South Asian origin may require lower doses of nifedipine.
Clinical Pharmacology Group, University of Southampton, United Kingdom.
C H
CH
Ahsan
A G
AG
Renwick
D G
DG
Waller
V F
VF
Challenor
C F
CF
George
M
M
Amanullah
D000328:Adult; D001459:Bangladesh / Q000208:ethnology; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D011485:Protein Binding; D012016:Reference Values; D044465:White People
D001798:Blood Proteins; D009543:Nifedipine