[Change in levels of specific terminal sugar residues of glycoproteins in sera of patients with malignant tumor].
Serum sialic acid (N-acetylneuraminic acid, NANA) levels significantly increased in all of patients with stomach cancer, colo-rectal cancer, breast cancer and pancreas cancer. However, the positive rate for serum NANA levels was 35 approximately 60% in these diseases. In contrast, a significant increase in serum NANA-galactose (NANA-Gal) levels was found in only stomach cancer and colo-rectal cancer; especially, the positive rate for serum NANA-Gal levels was 77% in colo-rectal cancer. In colo-rectal cancer, increased serum NANA-Gal levels were decreased after operation. But, in patients with colo-rectal cancer, changes in serum NANA levels following operation were variable. These results indicate that the assay of serum NANA-Gal level provides more important clinical significances for the specificity of cancer and the change of its status than that of serum NANA level.
Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake.
K
K
Nishida
Y
Y
Nagamura
Y
Y
Ohta
M
M
Ito
I
I
Ishiguro
D014408:Biomarkers, Tumor / Q000032:analysis; D005690:Galactose / Q000032:analysis; D006801:Humans; D009369:Neoplasms / Q000097:blood*; D012794:Sialic Acids / Q000097:blood* / Q000737:chemistry
D014408:Biomarkers, Tumor; D012794:Sialic Acids; D005690:Galactose