Thiazide-induced kidney damage with circulating antibodies against myeloperoxidase and cardiolipin.
A 79-year-old man developed a renal insufficiency while on thiazide. Extrarenal symptoms were absent. Screening for antibodies revealed high titre for anti-myeloperoxidase and anti-cardiolipin antibodies, but no other antibodies were present. After withdrawal of the drug the progression of renal insufficiency ceased. Four months later the both antibodies had disappeared. We conclude, that antibodies against granulocytes will become a valuable diagnostic tool in diagnosing drug-induced vasculitis.
Larsson
G B
GB
Department of Internal Medicine, County Hospital, Kungälv, Sweden.
Langer
L
L
Nässberger
L
L
D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001539:Bendroflumethiazide / Q000009:adverse effects*; D004232:Diuretics; D006801:Humans; D008297:Male; D009195:Peroxidase / Q000276:immunology*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects*
D017153:Antibodies, Anticardiolipin; D001323:Autoantibodies; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D001539:Bendroflumethiazide; D009195:Peroxidase