[Tumor properties of primary tumors and local recurrence of breast cancer].
In 137 patients suffering from a local recurrence after primary treatment of breast cancer, the features examined in a retrospective manner included: staging parameters (TNM-criteria), grading according to Bloom and Richardson, growth fraction by Ki67 positive cells as well as immunohistology and biochemical steroidreceptor-expression. In the primary tumours, a good correlation was detected between size of the tumour and lymph-node involvement, between histopathological grading and Ki67 growth fraction and between low histopathological grading and poor immunohistological and biochemical steroidreceptor content. The results of this particular study show that local recurrence is not accompanied by any significant de-differentiation, neither in its histopathological grading nor in its growth fraction nor in its steroidreceptor-status.
Torsten
U
U
Universitäts-Frauenklinik im Klinikum Steglitz, Freien Universität Berlin.
Opri
F
F
Moreno-Richter
I
I
Weitzel
H K
HK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D008137:Longitudinal Studies; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology*; D009687:Nuclear Proteins / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone