[The radioprotective efficacy and pharmacological properties of S,beta-amidinoethylthiophosphate].
S,beta-Amidinoethyl thiophosphate, a radioprotective agent that was synthesized and studied, was shown to have certain advantages over cystamine: it was effective when used in a lesser amount; it was less toxic, had higher therapeutic effect, and, in contrast to castamine, it did not inhibit physical efficiency of animals. S,beta-Amidinoethyl thiophosphate and gammaphos were very similar in properties.
Vladimirov
V G
VG
Strel'nikov
Iu E
IuE
Smirnova
S M
SM
Tarnapol'skaia
L G
LG
D004999:Amifostine / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D003538:Cystamine / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D008297:Male; D051379:Mice; D063086:Organothiophosphates / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats
D063086:Organothiophosphates; D011837:Radiation-Protective Agents; C080685:S-(2-amidinoethyl)thiophosphate; D004999:Amifostine; D003538:Cystamine