[The histamine-free diet].
Food intolerance is not IgE-mediated but caused by histamine. A diminished histamine degradation based on a deficiency of diaminoxidase is suspected to be the reason. The therapeutic efficacy of a histamine-free diet was evaluated in 100 patients with food intolerance and allergic diseases, who were required to avoid fish, cheese, hardcured sausage, pickled cabbage, wine and beer for 4 weeks. Considerable improvement was observed in 57 patients, 15 of whom had total remission. The most striking treatment results were obtained in food or wine intolerance (80% P < 0.05; treatment of choice), bronchial asthma (80%), headache (64%) and urticaria (58%). After ingestion of food rich in histamine clearcut recurrence of atopic eczema was seen in 50% of the patients affected. Histamine plays a major part in food and wine intolerance. Histamine in food causes worsening of symptoms in atopics and patients suffering from headache. The results obtained indicate a deficiency of diaminoxidase in patients with intolerance to food or wine. Histamine levels in alcoholic beverages should be displayed on the labels.
Wantke
F
F
Dermatologisches und pädiatrisches Allergieambulatorium Wien.
Götz
M
M
Jarisch
R
R
D000293:Adolescent; D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000172:deficiency / Q000502:physiology; D001249:Asthma / Q000178:diet therapy* / Q000201:enzymology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000178:diet therapy* / Q000201:enzymology; D005260:Female; D005512:Food Hypersensitivity / Q000178:diet therapy* / Q000201:enzymology; D006261:Headache / Q000178:diet therapy / Q000201:enzymology; D006632:Histamine / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000178:diet therapy / Q000201:enzymology; D012130:Respiratory Hypersensitivity / Q000178:diet therapy* / Q000201:enzymology; D014581:Urticaria / Q000178:diet therapy* / Q000201:enzymology; D014920:Wine / Q000009:adverse effects
D006632:Histamine; D006631:Amine Oxidase (Copper-Containing)