Arachidonic acid metabolites in human nasal polyps.
Arachidonic acid metabolites (AAMs) are known to be involved in inflammation. It is suggested that AAMs play an important role in the pathogenesis of nasal polyp. We have measured the levels of prostaglandin E2, 6-keto prostaglandin F1 alpha, thromboxane B2, leukotriene B4 and a mixture of leukotriene C4, D4 and E4 in both nasal polyp and maxillary sinus mucosa by radioimmunoassay. Our results showed that arachidonic acid metabolism in nasal polyps from allergic patients was more active than that from non-allergic patients. The arachidonic acid metabolism in nasal polyp was more active than in maxillary sinus mucosa among allergic patients. On the other hand, arachidonic acid metabolism in maxillary sinus mucosa was more active than that in nasal polyps among non-allergic patients. On the basis of these results, we hypothesized the causal mechanisms of nasal polyps as follows: The nasal polyp in allergic patients is caused by primary inflammation of the nasal mucosa, and sinusitis occurs secondarily. In non-allergic patients, the primary side of inflammation is located in the maxillary sinus mucosa, leading to the secondary formation of nasal polyp.
Department of Otolaryngology, Osaka University Medical School, Japan.
S
S
Ogino
M
M
Irifune
T
T
Harada
H
H
Kikumori
T
T
Matsunaga
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000293:Adolescent; D000328:Adult; D001095:Arachidonic Acids / Q000032:analysis* / Q000378:metabolism; D002648:Child; D015232:Dinoprostone / Q000032:analysis; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000032:analysis; D017999:Leukotriene E4; D008297:Male; D008443:Maxillary Sinus / Q000737:chemistry; D008875:Middle Aged; D009092:Mucous Membrane / Q000737:chemistry; D009298:Nasal Polyps / Q000737:chemistry*; D012130:Respiratory Hypersensitivity / Q000378:metabolism; D012220:Rhinitis / Q000378:metabolism; D013189:SRS-A / Q000031:analogs & derivatives / Q000032:analysis; D013929:Thromboxane B2 / Q000032:analysis
D001095:Arachidonic Acids; D013189:SRS-A; D007975:Leukotriene B4; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D017999:Leukotriene E4; D015232:Dinoprostone