Pulmonary fibrosis with megakaryocytoid cell infiltration in accelerated phase of chronic myelogenous leukaemia.
We report a patient in the accelerated phase of Philadelphia-chromosome-positive chronic myelogenous leukaemia who developed fibrosis in lungs, spleen and bone marrow. In the lungs, fibrosis was demonstrated in the alveolar septa which had been infiltrated by giant, bizarre-shaped cells resembling the megakaryocytes in the bone marrow. The relationship between the fibrosis and megakaryocytoid cell infiltration in the lungs is discussed.
Yamauchi
K
K
Department of Internal Medicine, Tokai University School of Medicine, Japan.
Oda
K
K
Shimamura
K
K
Arimori
S
S
Nagao
T
T
D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology; D015465:Leukemia, Myeloid, Accelerated Phase / Q000150:complications* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology