Five different histological subtypes of germ cell malignancies in an XY female.
A case of a 19-year-old female with 46 XY gonadal dysgenesis and five different histological subtypes of germ cell malignancies is described. Both adnexa were removed, preserving the uterus. Pathology revealed gonadoblastoma with dysgerminoma differentiation present in both gonads and in the left gonad mature teratoma, embryonal carcinoma, and endodermal sinus tumor were identified as well. She received no adjuvant treatment and has remained well 30 months after diagnosis.
Department of Obstetrics and Gynecology, University Hospital, Maastricht, The Netherlands.
G L
GL
Bremer
J A
JA
Land
A
A
Tiebosch
H W
HW
van der Putten
D000290:Adnexa Uteri / Q000473:pathology / Q000601:surgery; D000328:Adult; D004407:Dysgerminoma / Q000150:complications / Q000473:pathology / Q000601:surgery; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications* / Q000473:pathology; D006801:Humans; D008649:Mesonephroma / Q000150:complications / Q000473:pathology / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013724:Teratoma / Q000150:complications / Q000473:pathology / Q000601:surgery