Pediatric critical care pharmacodynamics.
Dosage requirements are different in the pediatric population due to ongoing development in pediatric patients from birth to adulthood. The pharmacologic response will depend on how the patient absorbs, distributes and excretes the drug as well as the sensitivity of "pediatric" receptors to the drug. The subjects of pharmacokinetics and pharmacodynamics encompass these relationships and help to explain the pharmacologic differences seen in children relative to adults.
Dionne
R
R
McManus
C
C
D000328:Adult; D000367:Age Factors; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008657:Metabolic Clearance Rate; D010372:Pediatrics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010600:Pharmacology; D011955:Receptors, Drug; D014018:Tissue Distribution
D004364:Pharmaceutical Preparations; D011955:Receptors, Drug