[Change in levels of specific terminal sugar residues of glycoproteins in sera of patients with malignant tumor].
Serum sialic acid (N-acetylneuraminic acid, NANA) levels significantly increased in all of patients with stomach cancer, colo-rectal cancer, breast cancer and pancreas cancer. However, the positive rate for serum NANA levels was 35 approximately 60% in these diseases. In contrast, a significant increase in serum NANA-galactose (NANA-Gal) levels was found in only stomach cancer and colo-rectal cancer; especially, the positive rate for serum NANA-Gal levels was 77% in colo-rectal cancer. In colo-rectal cancer, increased serum NANA-Gal levels were decreased after operation. But, in patients with colo-rectal cancer, changes in serum NANA levels following operation were variable. These results indicate that the assay of serum NANA-Gal level provides more important clinical significances for the specificity of cancer and the change of its status than that of serum NANA level.
Nishida
K
K
Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake.
Nagamura
Y
Y
Ohta
Y
Y
Ito
M
M
Ishiguro
I
I
D014408:Biomarkers, Tumor / Q000032:analysis; D005690:Galactose / Q000032:analysis; D006801:Humans; D009369:Neoplasms / Q000097:blood*; D012794:Sialic Acids / Q000097:blood* / Q000737:chemistry
D014408:Biomarkers, Tumor; D012794:Sialic Acids; D005690:Galactose