Tumor inhibition and hematopoietic stimulation in mice by a synthetic copper-ATP complex.
The hematologic effect of [Cu3(ATP)(2)6H2O]2-, a synthetic copper-ATP complex (Cu-ATP) having antitumor activity, was investigated in normal and Ehrlich ascites carcinoma-bearing mice. Cu-ATP (25 mg/kg) induced appreciable tumor inhibition and prolonged host survival which were accompanied by elevated levels of hemoglobin, platelet and lymphocytes while total WBC count and bone marrow cellularity remained unaffected. In normal mice the compound elicited marrow and splenic hypercellularity with a greater number of granulocyte progenitors and elevated levels of peripheral WBC, RBC and platelets. In addition, the total number of CFU-S of these treated animals was increased and these pluripotent stem cells differentiate preferentially towards granulocyte lineage. The results indicate that Cu-ATP does not adversely affect hematopoiesis while it inhibits tumor growth; on the contrary, it has a stimulatory effect on murine granulocytopoiesis.
Department of Cell Biology, Chittaranjan National Cancer Institute, Calcutta, India.
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D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002467:Cell Nucleus / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006413:Hematopoietic System / Q000166:cytology / Q000187:drug effects*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013268:Stimulation, Chemical
D006454:Hemoglobins; C033874:copper adenosine triphosphate; D000255:Adenosine Triphosphate