The dipeptide Lys-Pro attenuates interleukin-1 beta-induced anorexia.
The carboxyl-terminal tripeptide of alpha-MSH(1-13), Lys-Pro-Val, antagonizes anorexia induced by interleukin-1 beta (IL-1). The present studies were undertaken to determine if the Lys-Pro dipeptide portion of this tripeptide likewise antagonizes anorexia induced by ICV administration of 0.5 pmol IL-1 in rats previously deprived of food. This dose of Lys-Pro did significantly attenuate the IL-1-induced anorexia, but only for 1 h after infusion. Simultaneous administration of a larger dose (5.0 pmol) of Lys-Pro reversed the IL-1-induced anorexia during both the 0-1-h and 2-4-h periods. In addition, both 0.5 and 5.0 pmol of the D-substitute tripeptide, Lys-D-Pro-Thr (LDPT), similarly attenuated the IL-1-induced anorexia. The ICV administration of 5.0 pmol Lys-Pro also did not have any significant effects on food consumption. These results indicate that the dipeptide Lys-Pro may have a short-term antagonistic action against the anorexia induced by IL-1, and it is possible that this action may be partially mediated by the blockade of IL-1 on its own receptor.
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Y
Y
Uehara
H
H
Shimizu
N
N
Sato
Y S
YS
Mura
M
M
Mori
D000595:Amino Acid Sequence; D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000517:prevention & control*; D004151:Dipeptides / Q000494:pharmacology*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D053583:Interleukin-1beta; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017472:Receptors, Interleukin-1 / Q000187:drug effects / Q000378:metabolism; D000521:alpha-MSH / Q000737:chemistry / Q000494:pharmacology
D004151:Dipeptides; D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; D017472:Receptors, Interleukin-1; C056932:interleukin 1beta (193-195); C039356:lysylproline; D000521:alpha-MSH; C043156:MSH (11-13); D009074:Melanocyte-Stimulating Hormones