Vitamin E requirement of rats fed on a diet containing grains from the endemic region of Keshan disease.
Keshan disease (KD) is an endemic cardiomyopathy occurring in China. Combined selenium and vitamin E (VE) deficiency might be involved in the development of KD. It was shown in this paper that addition of 20 and 100 mg/kg DL-alpha-tocopherol tended to decrease malondialdehyde (MDA) content of myocardium in the rats receiving the low selenium (0.013 ppm) grains from the endemic region of KD, but not to a statistically significant extent. And addition of 200 mg/kg DL-alpha-tocopherol significantly decreased the myocardial MDA content, which suggested that VE requirement of the rats receiving KD endemic grains was 200 mg/kg DL-alpha-tocopherol. However, the MDA content in the myocardium of rats receiving KD grains added with 100 mg/kg DL-alpha-tocopherol was significantly decreased when selenium (0.1 ppm) was supplemented, which suggested that VE requirement of these rats was decreased to 100 mg/kg DL-alpha-tocopherol in the presence of selenium. The ability of VE in counteracting free radicals in myocardium of rats appeared greater than that of selenium.
Pathophysiology Department of Beijing Medical University, China.
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Yang
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Wang
D000818:Animals; D009202:Cardiomyopathies / Q000150:complications / Q000378:metabolism / Q000517:prevention & control*; D002681:China; D004195:Disease Models, Animal; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000172:deficiency* / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000150:complications / Q000517:prevention & control*
D014810:Vitamin E; D008315:Malondialdehyde; D012643:Selenium