[Effect of captopril and lisinopril on adrenergic receptor density and serum norepinephrine and epinephrine in patients with congestive heart disease].
Density of beta-adrenergic receptors in the lymphocytes, alpha 1- and alpha 2-adrenergic receptors in blood platelets, as well as blood serum norepinephrine levels have been assessed in 49 patients with congestive heart failure prior to, and 7 and 14 days of captopril and lisinopril administration. A decrease in beta-, alpha 1-, and alpha 2-adrenergic receptors density, an increase in blood serum norepinephrine, and normal epinephrine levels have been noted in these patients. A 7-day treatment with captopril, and a 14-day treatment with lisinopril have increased adrenergic receptors density, and decreased blood serum norepinephrine levels.
Katedry i Kliniki Kardiologii AM, Wrocławiu.
B
B
Halawa
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D004151:Dipeptides / Q000627:therapeutic use*; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D011941:Receptors, Adrenergic / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D011941:Receptors, Adrenergic; D002216:Captopril; D017706:Lisinopril; D009638:Norepinephrine; D004837:Epinephrine