Plasma lipid and lipoprotein levels in perimenopausal women. Clinical research in 1198 Japanese women.
Hyperlipidemia is associated with an increased prevalence of cardiovascular and cerebrovascular disease. We studied plasma lipid and lipoprotein levels with a survey of endocrine changes in the perimenopausal Japanese women. Total cholesterol, triglyceride, and low density lipoprotein cholesterol levels increased with age, whereas high density lipoprotein cholesterol level fell slightly. The rise in triglyceride and low density lipoprotein levels were particularly more marked just before the onset of the menopause. It might be important that the rapid rise of triglyceride and low density lipoprotein levels at about the menopause age was associated with a decline of estrogen levels. The percentage of hyperlipidemia in the perimenopausal women who showed total cholesterol level exceeding 5.7 mmol/l (220 mg/dl) and low density lipoprotein cholesterol level exceeding 3.9 mmol/l (150 mg/dl) were 31.9% and 27.2%, respectively. It was concluded that we need to recognize relatively high incidence of hyperlipidemia in perimenopausal period, and need to pay careful attention to plasma lipid and lipoprotein levels for prevention of coronary heart disease in perimenopausal women.
Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Japan.
T
T
Ushiroyama
Y
Y
Okamoto
O
O
Sugimoto
D000328:Adult; D000367:Age Factors; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D004958:Estradiol / Q000097:blood; D004964:Estriol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007564:Japan; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol; D004964:Estriol