[Nuclear state splitting: a working model for the mechanochemical coupling of differentiation "waves" with the controlling genes (master genes)].
The cell state splitter (CSS) model for differentiation, supported by recent evidence, requires that an intracellular mechanical events result in a commitment signal to the nucleus that determines which of two readied gene cascades is to be activated, via their master genes. We show how a link between the mechanochemistry of cell state splitting and the molecular genetics of "nuclear state splitting" might be forged out of well known molecular components of cells.
University of Manitoba, Winnipeg, Canada.
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Bjorklund
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Gordon
D000818:Animals; D005075:Biological Evolution; D001696:Biomechanical Phenomena; D015220:Calcium Channels / Q000502:physiology; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004817:Epidermis / Q000196:embryology; D005775:Gastrula / Q000648:ultrastructure; D005796:Genes; D005809:Genes, Regulator; D008954:Models, Biological; D015398:Signal Transduction
D015220:Calcium Channels