Inversion of a chicken ets-1 proto-oncogene segment in avian leukemia virus E26.
The segment of the avian leukemia virus E26 genome near the termination of the p135gag-myb-ets open reading frame contains an inversion of the chicken ets-1 sequence. The inversion contains at least 41 bp and may be as large as 46 bp. This results in the replacement of 13 amino acids of chicken ets-1, with 16 amino acids derived from reverse complement of the normal ets-1 coding strand or read-through into E26 env sequences. At least 13 of these codons are specified by the inverted ets sequences. This represents the first reported occurrence of inverted oncogene sequences in a natural retrovirus. The inverted ets sequences are immediately followed by sequences homologous to the Rous sarcoma virus Prague B env gene. Since the E26 env sequence is more closely related to subgroup B avian retroviruses than to avian retroviruses from subgroups A, C, D, or E, the progenitor of E26 was a virus belonging to avian retrovirus subgroup B.
Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21702-1201.
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Lautenberger
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Papas
D001354:Avian Leukosis Virus / Q000235:genetics*; D001483:Base Sequence; D007446:Chromosome Inversion; D005814:Genes, Viral / Q000235:genetics*; D008969:Molecular Sequence Data; D011519:Proto-Oncogenes / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D015682:Retroviridae Proteins, Oncogenic; D012689:Sequence Homology, Nucleic Acid
D012333:RNA, Messenger; D015682:Retroviridae Proteins, Oncogenic