The effect of nicardipine on maternal and fetal hemodynamics and uterine blood flow in chronically instrumented pregnant goats.
This study was designed to clarify the maternal and fetal hemodynamics of nicardipine (0.02 mg/kg) administered intravenously to unanesthetized, chronically instrumented pregnant goats. Nicardipine produced a significant increase in maternal heart rate and cardiac output, and a significant decrease in maternal mean arterial blood pressure and systemic vascular resistance. These changes persisted for about 30 minutes. There were no consistent changes in maternal pulmonary hemodynamics. Uterine arterial blood flow (UBF) decreased significantly (about 15%) after 5 minutes of the injection and returned to the control value within 30 minutes. A significant correlation between the decreases in UBF and maternal diastolic blood pressure was observed after 5 minutes of the injection. The fetal heart rate, blood pressure and acid-base status did not change after the injection of nicardipine. These observations of pregnant goats suggest that nicardipine might be a useful agent for the treatment of acutely hypertensive crises in pregnant patients.
Matsuda
Y
Y
Department of Obstetrics and Gynecology, Kagoshima Municipal Hospital, Japan.
Ikenoue
T
T
Matsuda
K
K
Sameshima
H
H
Ibara
S
S
Hokanishi
H
H
Sakamoto
H
H
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects; D006041:Goats; D006439:Hemodynamics / Q000187:drug effects*; D008991:Monitoring, Physiologic / Q000295:instrumentation; D009529:Nicardipine / Q000494:pharmacology*; D011247:Pregnancy; D012039:Regional Blood Flow; D014599:Uterus / Q000098:blood supply*
D009529:Nicardipine