The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution in Coronaviridae.
The nucleoprotein-encoding gene (N) of murine hepatitis virus type 3 (MHV 3), from the Mill Hill strain, was cloned and sequenced. It was compared to gene N from other murine coronaviruses and was found to share more similarities with N sequences from MHV 1 and MHV JHM strains than with the published MHV 3 N sequence which is almost identical to MHV A59. We suggest that the evolution of some MHV N sequences resulted from a double recombination phenomenon between two ancestors. Furthermore, comparison of protein N from avian and mammalian coronaviruses leads to the hypothesis that horizontal transfer events of the virus from one host species to another have occurred.
Décimo
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INSERM Unité 347 affiliée au CNRS, Université Paris XI, Hôpital de Kremlin-Bicêtre, France.
Philippe
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Hadchouel
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Tardieu
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Meunier-Rotival
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D001717:Birds; D002213:Capsid / Q000737:chemistry / Q000235:genetics*; D003332:Coronaviridae / Q000235:genetics*; D008322:Mammals; D008969:Molecular Sequence Data; D006517:Murine hepatitis virus / Q000235:genetics*; D016366:Open Reading Frames; D011995:Recombination, Genetic; D014758:Viral Core Proteins / Q000737:chemistry / Q000235:genetics*
D014758:Viral Core Proteins