Marked species-difference in the vascular angiotensin II-forming pathways: humans versus rodents.
Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensin II formation was ascribed to chymostatin-sensitive angiotensin II-generating enzyme (CAGE). On the contrary, angiotensin II formation in rodent arteries totally depended upon ACE, without any sign of CAGE involvement. Such a marked species-difference can be relevant to the reported difference between humans and rodents in the ACE inhibitor effects on the myointimal hyperplasia after intimal balloon injury.
Okunishi
H
H
Department of Pharmacology, Osaka Medical College, Japan.
Oka
Y
Y
Shiota
N
N
Kawamoto
T
T
Song
K
K
Miyazaki
M
M
D000328:Adult; D000368:Aged; D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000096:biosynthesis*; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D002216:Captopril / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000378:metabolism; D013045:Species Specificity
D009842:Oligopeptides; D000804:Angiotensin II; D000803:Angiotensin I; C002101:chymostatin; D002216:Captopril; D012697:Serine Endopeptidases; C054542:chymostatin-sensitive angiotensin II-generating enzyme