[Nuclear medicine studies of tissue concentration and hemodynamic effects of retrograde intravenous pressure infusions].
In 12 patients with trophic foot-lesions (diabetic feet) retrograde intravenous pressure infusions (150 ml) containing radioactive tracers (99m Tc, 99m Tc labelled human serum albumin) were carried out. With the veins emptied time-activity curves over the legs reflect tissue concentrations after release of the occlusion. Tissue-concentration is about 3 times higher than after intraarterial and 7 times higher than after intravenous injection of the same dose. The high count-rates which can be measured in the wound-secretion demonstrate the "rinsing effect" of the injected fluid. Hemodynamic investigations have been performed in a double blind study. 8 patients received buflomedil and 9 got placebo 3 times per week by retrograde intravenous pressure infusions. After 3 weeks there was an increase of the peak-flow on the lower leg (venous occlusion plethysmography), an increase of transcutaneous oxygen pressure and a fall of peak flow-time and of plasma-viscosity, both for buflomedil and for placebo (without statistical significance). Preliminary investigations after an arterial occlusion for 1 hour showed an increase of flow-values measured by venous occlusion plethysmography which reached a maximum after 4 to 5 days.
Partsch
H
H
Dermatologischen Abteilung, Wilhelminenspitals der Stadt Wien.
Jochmann
W
W
Mostbeck
A
A
Hirschl
M
M
D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D010478:Chemotherapy, Cancer, Regional Perfusion; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging* / Q000188:drug therapy; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging* / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D005528:Foot / Q000098:blood supply; D016523:Foot Ulcer / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D011759:Pyrrolidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D015424:Reperfusion; D012711:Serum Albumin, Radio-Iodinated; D013670:Sodium Pertechnetate Tc 99m; D014111:Tourniquets; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*
D011759:Pyrrolidines; D012711:Serum Albumin, Radio-Iodinated; D014665:Vasodilator Agents; D013670:Sodium Pertechnetate Tc 99m; C010651:buflomedil