[Treatment and course of desmoid tumors in 5 patients with familial adenomatous polyposis].
Four patients are described with familial adenomatous polyposis and an intra-abdominal desmoid tumour located in the mesentery of the small bowel; the fifth patient had a tumour in the abdominal wall. In all patients a colectomy had been performed several years prior to the development of the tumours. Radical resection of the desmoid tumours was not possible because of the location in the mesentery; repeated resection or partial excision was performed in all four patients. NSAIDs, tamoxifen, norethisterone and interferon alpha appeared to have only a temporary effect on the growth of the desmoid tumour. The effect of goserelin, a gonadorelin analogue, on the behaviour of the desmoid tumour appears promising, as two patients treated with it showed no tumour growth after 4 and 16 months respectively.
Academisch Ziekenhuis Rotterdam-Dijkzigt.
J H
JH
van Dam
W R
WR
Schouten
T C
TC
Kok
D000008:Abdominal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000601:surgery; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005350:Fibroma / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D005736:Gardner Syndrome / Q000150:complications / Q000601:surgery; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012008:Recurrence
D017273:Goserelin