Waldenström hypergammaglobulinemic purpura and pregnancy.
BACKGROUND
Waldenström hypergammaglobulinemic purpura is characterized by hypergammaglobulinemia, recurring purpura, and an elevated erythrocyte sedimentation rate. It is a rare disease and, to our knowledge, there have been no previous reports of its presence during pregnancy. We report a patient with this disease whose pregnancy was complicated by severe fetal growth restriction (FGR) and acute fetal distress.


METHODS
A 24-year-old primigravid woman with a history of Waldenström hypergammaglobulinemic purpura and renal insufficiency developed FGR at 32 weeks' gestation. Cesarean delivery was performed at 33.5 weeks because of acute fetal distress, and a 1305-g male infant was delivered. Neonatal outcome was successful. No deterioration of the woman's medical condition occurred during or after her pregnancy.


CONCLUSIONS
Successful pregnancy outcome is possible in women with Waldenström hypergammaglobulinemic purpura. In view of the risk of FGR, close monitoring of fetal growth and well-being is recommended in women with this condition.
Department of Obstetrics and Gynecology, University of Western Ontario, London, Canada.
V Y
VY
Cheung
A D
AD
Bocking
D
D
Hollomby
R
R
Gagnon
J
J
Walton
D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy; D011694:Purpura, Hyperglobulinemic / Q000150:complications / Q000628:therapy; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000628:therapy