Technological testing of calcium carbonate tablets for use in the treatment of renal osteodystrophy.
Samples of calcium carbonate tablets produced by different manufacturers were subjected to various tests in order to evaluate tablet quality parameters, mostly indicative for calcium availability. Indications about tablet suitability for treatment of renal osteodystrophy in uremic patients were also tested. The disintegration test turned out to be the most useful in evaluating calcium carbonate availability from tablets. Samples from several manufacturers varied in their behaviour to disaggregation. The availability of calcium dissolved in gastric fluid and the extent of phosphorus binding appeared to depend on disintegration behaviour.
Dipartimento di Scienze Farmaceutiche dell'Università di Padova.
M
M
Dal Zotto
E
E
Ragazzi
N
N
Realdon
G
G
Dalla Fini
D002119:Calcium Carbonate / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy*; D006245:Hardness Tests; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010316:Particle Size; D010758:Phosphorus / Q000737:chemistry; D011786:Quality Control; D012995:Solubility; D013607:Tablets
D013607:Tablets; D010758:Phosphorus; D002119:Calcium Carbonate