Protective effects of tetrahydroneopterin against free radical-induced injury.
The therapeutic potency of 5,6,7,8-tetrahydroneopterin (NPH4) was investigated in ischemic paw edema, Adriamycin (ADR)-induced cardiotoxicity, and endotoxin [lipopolysaccharide (LPS)]- and carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. Ischemic paw edema was completely suppressed by pre-administration of NPH4. ADR-induced cardiotoxicity and LPS-induced hepatotoxicity were significantly decreased by post-administration of NPH4. Furthermore, NPH4 ameliorated CCl4-induced hepatotoxicity. These results suggest that NPH4 may be useful for the treatment of free radical, especially superoxide radical, -related tissue injury.
Applied Technology Research Laboratory, Asahi Breweries Ltd, Tokyo, Japan.
T
T
Icho
S
S
Kojima
N
N
Shinohara
Y
Y
Kajiwara
K
K
Kitabatake
K
K
Kubota
D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D004317:Doxorubicin / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005528:Foot / Q000098:blood supply; D005534:Foot Diseases / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D005552:Forelimb; D016166:Free Radical Scavengers; D005609:Free Radicals / Q000633:toxicity; D006614:Hindlimb; D007511:Ischemia / Q000188:drug therapy / Q000517:prevention & control; D008070:Lipopolysaccharides; D008107:Liver Diseases / Q000517:prevention & control; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000517:prevention & control; D013481:Superoxides / Q000633:toxicity*
D016166:Free Radical Scavengers; D005609:Free Radicals; D008070:Lipopolysaccharides; D013481:Superoxides; D001708:Biopterins; C023455:tetrahydroneopterin; D004317:Doxorubicin; D002251:Carbon Tetrachloride