Effect of caval-portal shunt on ovarian tissue in rats: I. Histological observation.
Forty-three female Sprague Dawley rats were divided into five groups, with groups 1-4 subjected to end-to-side caval-portal shunt (CPS). In addition to CPS, group 1 (n = 13), group 2 (n = 10), and group 3 (n = 7) rats had undergone removal of the right ovary and one-half of the left ovary, the left ovary, and one-half of the left ovary, respectively. Group 4 (n = 6) rats were not subjected to ovariectomy. Group 5 (n = 7) animals were not subjected to CPS but underwent left ovarian hemiresection. The ovarian volume of the hemiresected ovaries increased to 393.00 +/- 4.83 mm3 and 126.00 +/- 44.3 mm3 from 18.40 +/- 0.54 mm3 and 18.40 +/- 0.59 mm in groups 1 and 3, respectively, at the end of three postoperative months. The nonresected ovaries enlarged to 339.98 +/- 5.09 mm3 and 226.3 +/- 46.2 mm3 from 36.79 +/- 1.09 mm3 in groups 2 and 3, respectively. When no ovaries were resected, the CPS animals in group 4 showed an increment of ovarian volume of 1.75-2.2 times as much as the preoperative ones. In the animals that had undergone simple hemiovariectomy (group 5), the contralateral ovaries showed a significant increase in volume (40.2 +/- 8.3 mm3 to 243.1 +/- 114.8 mm3) at 3 months. The hemiresected ovarian volume increased from 27.1 +/- 5.5 mm3 to 44.1 +/- 11.8 mm3.(ABSTRACT TRUNCATED AT 250 WORDS)
San Diego Microsurgical Institute, Mercy Hospital, CA 92103.
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Chung
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Mao
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D'Silva
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Fazi
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Bai
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Subin
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Coopersmith
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Wolf
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Gittes
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Lee
D000818:Animals; D005260:Female; D010048:Ovarian Cysts / Q000209:etiology* / Q000473:pathology; D006080:Ovarian Follicle / Q000502:physiology; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D010052:Ovariectomy; D010053:Ovary / Q000098:blood supply / Q000473:pathology*; D011167:Portacaval Shunt, Surgical; D051381:Rats; D017207:Rats, Sprague-Dawley; D013798:Thecoma / Q000209:etiology* / Q000473:pathology; D013997:Time Factors