Antigenic relatedness between ovine progressive pneumonia virus (OPPV) and HIV-1.
The antigenic relatedness between ovine progressive pneumonia virus (OPPV), a lentivirus that infects sheep, and human immunodeficiency virus (HIV-1) was examined by immunoblot analysis. Fourteen of 20 sheep sera, that were positive for OPPV antibodies on an immunodiffusion test, reacted with HIV-1 p24 on a commercial blot of HIV-1 and cell lysate proteins (Virostat, Portland, Maine). Sheep OPPV antisera did not bind to cellular antigens on a negative control blot of cellular proteins. There was no correlation between the ability to bind to HIV-1 p24 and the status of disease in the sheep. Twenty human anti-HIV-1 sera and two human HIV-1 negative sera were tested on OPPV and cell lysate (OPPV-CON) and cell lysate (CON) protein blots. None of the human serum samples tested reacted to OPPV specific proteins.
Respiratory Disease Research Unit, National Animal Disease Center, USDA-ARS, Ames, IA 50010.
D M
DM
Maslak
M J
MJ
Schmerr
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D003429:Cross Reactions; D015483:HIV Antibodies / Q000276:immunology; D015488:HIV Antigens / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D011021:Pneumonia, Progressive Interstitial, of Sheep / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013045:Species Specificity; D014790:Visna-maedi virus / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24