[Recent advances in the molecular biology of voltage-sensitive Na+ channels].
Na+ channels play a crucial role in generating action potentials in neurones and other excitable cells. alpha-subunits, composed of four homologous repeats, are responsible for most of the Na+ channel properties. The combination of molecular biology with electro-physiological tools has proved useful for understanding the molecular mechanism of the channel function. Activation, inactivation and ion permeation occur, based on Segment 4, III-IV linker, the region intervened by Segment 5 and 6, respectively. Mutations in a human skeletal muscle Na+ channel gene cause heritable muscle disorders, hyperkalemic periodic paralysis and paramyotonica congenita. Future directions in Na+ channel studies may include gene regulation of the Na+ channel related to neural cell fate and subcellular localization of channel molecules concurrent with plasticity or development.
Okamura
Y
Y
Department of Neurobiology, Faculty of Medicine, University of Tokyo.
D000200:Action Potentials; D000595:Amino Acid Sequence; D000818:Animals; D008969:Molecular Sequence Data; D015222:Sodium Channels / Q000235:genetics / Q000502:physiology*
D015222:Sodium Channels