Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa.
A new C31 lanostane-type triterpene, assigned the trivial name suberosol [1], has been isolated from Polyalthia suberosa as an anti-HIV principle. The structure has been characterized as 24-methylenelanost-7,9(11)-diene-3 beta, 15 alpha-diol (suberosol) [1], based on spectroscopic evidence. Compound 1 was found to show anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 micrograms/ml.
Li
H Y
HY
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
Sun
N J
NJ
Kashiwada
Y
Y
Sun
L
L
Snider
J V
JV
Cosentino
L M
LM
Lee
K H
KH
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D016655:HIV Core Protein p24 / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000998:Antiviral Agents; D016655:HIV Core Protein p24; D013256:Steroids; C083158:suberosol