[Portal blood levels of 5-FU administered intraperitoneally].
Portal blood levels of 5-FU were measured after intraperitoneal administration of 15 mg/kg of 5-FU in two patients who had a bypass operation for unresectable pancreatic cancer. The portal concentration of 5-FU increased rapidly. Tmax was 8-11 minutes and Cmax was 29-31 micrograms/ml. The peripheral blood levels followed the portal levels. Also, AUC of the portal levels seemed to be higher than the peripheral levels. The direct instillation of 5-FU into the peritoneal cavity might offer an alternative means of achieving higher regional drug levels, such as intraperitoneal and intraportal levels, without enhanced systemic toxicity.
Dept. of Surgery, Sendai National Hospital.
K
K
Kakizaki
S
S
Teshima
H
H
Yamauchi
D005472:Fluorouracil / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D010190:Pancreatic Neoplasms / Q000097:blood / Q000188:drug therapy; D011169:Portal Vein
D005472:Fluorouracil