Combined central and peripheral acute demyelination.
We describe a patient with multiple sclerosis who had a bout of central demyelination associated with an acute inflammatory demyelinating polyneuropathy. The contemporary involvement of central and peripheral nervous system due to a demyelinating disease has been reported anecdotically in humans, and can be induced experimentally in animals. It may be sustained by a common pathogenetic factor.
Pareyson
D
D
III Divisione di Neurologia, Istituto Nazionale Neurologico C. Besta, IRCCS, Milano.
Ciano
C
C
Fiacchino
F
F
Gemma
M
M
Savoiardo
M
M
Sghirlanzoni
A
A
D000328:Adult; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D003711:Demyelinating Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009046:Motor Neurons / Q000502:physiology; D009069:Movement Disorders / Q000209:etiology; D009431:Neural Conduction; D009475:Neurons, Afferent / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use
D011241:Prednisone