[Pioneer experience with buflomedil in the form of retrograde venous pulse therapy for treatment of ischemia and severe extremity infections].
Retrograde venous pulse therapy (RVP) allows faster healing of the infection, shortening of hospitalization time, and recovering of the chronic ischemia. RVP als has a dramatic effect on diabetic foot by passing the functional disorder of the microcirculation produced by diabetic neuropathy and micro-angiopathy, with important reduction of amputation rates in these patients. We credit these results to the very high concentration of Buflomedil provided by RVP in the target tissues, which allows the penetration and impregnation of other active substances (7).
Gefässchirurgischen Abteilung, Jundiai School of Medicine, Public Charity Hospital, Sao Vicente de Paulo, Sao Paulo, Brasilien.
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Cavini-Ferreira
D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy*; D010478:Chemotherapy, Cancer, Regional Perfusion; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007262:Infusions, Intravenous; D007511:Ischemia / Q000097:blood / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008657:Metabolic Clearance Rate / Q000502:physiology; D008833:Microcirculation / Q000187:drug effects; D011759:Pyrrolidines / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics
D005839:Gentamicins; D011759:Pyrrolidines; D014665:Vasodilator Agents; D003907:Dexamethasone; C010651:buflomedil