Laminin matrix formation and S-100 protein and/or desmin-positive cells in malignant fibrous histiocytoma (MFH).
16/30 human storiform-pleomorphic malignant fibrous histiocytomas (MFH) showed a focal pericellular immunostaining for laminin. 14/16 of these laminin-positive tumours additionally revealed an atypical cellular differentiation (desmin- and/or S-100 protein-positive cells). The significance of focal laminin positivity along with atypical, non-entity specific differentiated cells is discussed before the background of laminin as being an indicator and promoter of differentiation in MFH. The limited value of a laminin detection in MFH for solving differential diagnostic questions (MFH versus other poorly differentiated sarcomas with basement membrane formation) has been pointed out.
Institute of Pathology, Friedrich Schiller University, Jena, FRG.
H
H
Kosmehl
L
L
Langbein
D
D
Katenkamp
W
W
Vogel
A
A
Berndt
D002454:Cell Differentiation; D003893:Desmin / Q000276:immunology / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000378:metabolism*; D016612:Paraffin Embedding; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism*
D003893:Desmin; D007797:Laminin; D009418:S100 Proteins