Expression of common acute lymphoblastic leukemia antigen (CD 10) by myelinated fibers of the peripheral nervous system.
The common acute lymphoblastic leukemia antigen (CALLA), CD10, is a 100-kDa surface glycoprotein endowed with neutral endopeptidase activity, shared by a number of hemopoietic and non-hemopoietic cells. In this report, immunohistochemical and Western blot techniques, using different anti-CD10 monoclonal antibodies, were utilized to demonstrate that CD10 is also expressed by myelin sheaths of the human peripheral nervous system (PNS), but not of the central nervous system. CD10-positive immunoreactivity appeared to be localized in the outer and inner borders of myelinated fibers, in nodes of Ranvier and in the Schmidt-Lantermann clefts, thus showing a distribution pattern very similar to that of myelin-associated glycoprotein (MAG). The above findings suggest that CD10 antigen, through its enzymatic activity, may have a functional role in the assembly and maintenance of PNS myelin. In addition, it is not known whether CD10, similarly to MAG, may be a target antigen in some PNS immune-mediated disorders.
Institute of Human Anatomy, University of Genoa, Italy.
A
A
Cadoni
G L
GL
Mancardi
D
D
Zaccheo
A
A
Nocera
S
S
Barocci
D
D
Bianchini
A
A
Schenone
E
E
Capello
A
A
Zicca
D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D015153:Blotting, Western; D003711:Demyelinating Diseases / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D015260:Neprilysin / Q000276:immunology / Q000378:metabolism*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism
D000911:Antibodies, Monoclonal; D015260:Neprilysin