Activation of mouse renin promoter by cAMP and c-Jun in a kidney-derived cell line.
We demonstrated that the mouse renin promoter from -365 to +16 can mediate the activation by cAMP and c-Jun in a kidney-cell dominant manner. Deletion analysis indicated that the region from -75 to -48 was responsible for the activation by cAMP. Furthermore, the core promoter region from -47 to +16 was sufficient to confer c-Jun inducibility.
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
K
K
Tamura
K
K
Tanimoto
K
K
Murakami
A
A
Fukamizu
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D000242:Cyclic AMP / Q000494:pharmacology*; D004252:DNA Mutational Analysis; D005786:Gene Expression Regulation / Q000187:drug effects*; D016758:Genes, jun; D007668:Kidney; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012083:Renin / Q000235:genetics*; D014162:Transfection
D000242:Cyclic AMP; D012083:Renin