A case of transitional cell carcinoma of the bladder with a del(9)(q11q21.2).
Monosomy for chromosome 9, as well as loss of heterozygosity for markers on this chromosome, has been detected in a high percentage of transitional cell carcinomas (TCC) of the bladder. We report a case of a TCC of the bladder with an interstitial del(9)(q11q21.2) that could be indicative of the presence of a putative tumor-suppressor gene related to bladder tumor progression. To elucidate the role of chromosome 9 in bladder tumors, it would be interesting to study a possible loss of heterozygosity in this chromosome region.
Bernués
M
M
Institut de Biologia Fonamental Vincent Villar Palasí, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Casadevall
C
C
Miró
R
R
Caballín
M R
MR
Gelabert
A
A
Egozcue
J
J
D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D016147:Genes, Tumor Suppressor; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000235:genetics*