An investigation into the effects of chloroquine on fertility of male rats.
We investigated the effect of chloroquine on the fertility of adult male rats. Rats were administered chloroquine at a daily intra-peritoneal dose of 10mg/kg body weight and 40mg/kg body weight per rat, five days a week for 16 weeks. Females mated with treated males showed a dose dependent decrease in the number of litter per female rat. In the in-vitro studies, more than 80% os spermatozoa were immotile in all concentrations of chloroquine tested. These results suggest that chloroquine brings about its antifertility effect by decreasing sperm motility.
Department of Anatomy, College of Medicine, University of Lagos, Nigeria.
A O
AO
Okanlawon
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CC
Noronha
O A
OA
Ashiru
D000818:Animals; D001835:Body Weight; D002738:Chloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005298:Fertility / Q000187:drug effects*; D007248:Infertility, Male / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008098:Litter Size / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013081:Sperm Motility / Q000187:drug effects*
D002738:Chloroquine