Antagonist for atrial natriuretic peptide receptors ameliorates glomerular hyperfiltration in diabetic rats.
To evaluate the possible contribution of atrial natriuretic peptide (ANP) to the development of glomerular hyperfiltration, we examined the effect of non-peptide competitive antagonist for biological receptors of ANP, HS-142-1, on glomerular filtration rate (GFR) and renal plasma flow (RPF) in diabetic rats. Increased GFR and RPF in diabetic rats were significantly ameliorated by the injection of HS-142-1, while blood pressure remained unchanged. Urinary cyclic GMP excretion was significantly higher in diabetic rats than in control rats and HS-142-1 decreased urinary cGMP excretion significantly. These results indicate that atrial natriuretic peptide contributes to the development of glomerular hyperfiltration and hyperperfusion in diabetes and HS-142-1 might be useful in the treatment of them.
Third Department of Medicine, Shiga University of Medical Science, Japan.
R
R
Kikkawa
M
M
Haneda
K
K
Sakamoto
D
D
Koya
T
T
Shikano
S
S
Nakanishi
Y
Y
Matsuda
Y
Y
Shigeta
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000037:antagonists & inhibitors*; D001786:Blood Glucose / Q000378:metabolism; D006152:Cyclic GMP / Q000652:urine; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D049528:Insulin, Long-Acting / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017461:Receptors, Atrial Natriuretic Factor / Q000037:antagonists & inhibitors*; D012016:Reference Values; D012079:Renal Circulation / Q000187:drug effects
D001786:Blood Glucose; C072551:HS 142-1; D049528:Insulin, Long-Acting; D011134:Polysaccharides; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor; D006152:Cyclic GMP