Immunoelectron identification of endoneurial IgM deposits in four patients with Waldenström's macroglobulinemia: a specific ultrastructural pattern related to the presence of cryoglobulin in one case.
In four patients with Waldenström's macroglobulinemia and peripheral neuropathy, direct immunofluorescence on a peripheral nerve biopsy revealed the presence of IgM deposits in the endoneurium. At ultrastructural examination, these endoneurial deposits were granulo-fibrillar in three cases, and tubular in the fourth, in whom a cryoglobulin was evidenced in the serum. In each case the endoneurial deposits were also identified as IgM by post-embedding immunoelectron microscopy with good preservation of the characteristic ultrastructural details.
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Department of Neuropathology, Bordeaux II University, France.
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D000368:Aged; D000369:Aged, 80 and over; D003450:Cryoglobulins / Q000032:analysis* / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis / Q000648:ultrastructure; D007075:Immunoglobulin M / Q000032:analysis* / Q000648:ultrastructure; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000648:ultrastructure; D008297:Male; D016253:Microscopy, Immunoelectron; D008870:Microtubules / Q000648:ultrastructure; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000473:pathology*; D010543:Peroneal Nerve / Q000473:pathology / Q000648:ultrastructure; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology / Q000473:pathology*
D003450:Cryoglobulins; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains