Optimization of release from magnetically controlled polymeric drug release devices.
Release rates from drug:polymer matrices embedded with small magnets increase in the presence of oscillating magnetic fields. Previous studies of these systems have defined those parameters that determine the extent of the increase in release, and implied that not only was the force generated within the matrix an important determinant of the extent of modulation but also that the greater the amount of matrix actually displaced, the greater the observed modulation. We investigated this possibility in the magnetic system and developed a model taking into account the intersection of the volume of a cylindrical polymer-drug magnet embedded matrix with an imaginary sphere representing the upper limit of matrix deformation by the magnet. The intersection correlated in a linear fashion with the increase in release (slope = 1.16 +/- 0.26, R = 0.864, P = 0.003, s.e.e. = 1.38). Magnet orientation alone was insufficient to explain the data. It appears that a modulated system is optimized when the modulating force overlaps precisely with the maximum amount of matrix drug that can be released. If the size of the matrix, position of the magnet, force generated on the matrix by the magnet, viscoelastic properties of the matrix, etc. are not matched then modulation is inefficient. These results should provide further insight into and a means of optimization for externally regulated controlled release systems.
Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139.
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Edelman
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Langer
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008280:Magnetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry; D013997:Time Factors
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers