Anogenital warts in children.
Fourteen children presenting with anogenital (AG) warts and their close family members were studied; 28.6 and 8.3% of presenting children and other child household members, respectively, had non-genital cutaneous warts; 42.8% of children with AG warts had one or more adult household member with common hand warts. Fifty per cent of all mothers had subclinical cervical papilloma virus (PV) infection; only one male adult had subclinical PV infection of the penis without concurrent AG warts. Of the children with AG warts 42.8% had one or more adult household member with AG warts. Human papilloma virus (HPV) deoxyribonucleic acid (DNA), type 6/11 most frequently, was detected in 38.5% AG wart biopsies from children, and 67% AG wart biopsies from adults. HPV 31/33/35 was detected in 28.5% of cervical preneoplasias and type 6/11 in the one case of subclinical PV infection of the penile shaft. Detection of HPV types 6/11, 16/18, or 31/33/35 in AG warts in children was significantly associated with vertical (from an HPV-infected maternal birth canal during vaginal delivery) or sexual transmission of these warts (Fisher exact probability P = 0.031).
Handley
J M
JM
Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast, Northern Ireland.
Maw
R D
RD
Bingham
E A
EA
Horner
T
T
Bharucha
H
H
Swann
A
A
Lawther
H
H
Dinsmore
W W
WW
D001004:Anus Diseases / Q000382:microbiology*; D002648:Child; D002650:Child Abuse, Sexual / Q000382:microbiology; D002675:Child, Preschool; D003218:Condylomata Acuminata / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis; D005192:Family Health; D005260:Female; D006229:Hand Dermatoses / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D027383:Papillomaviridae / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000382:microbiology*; D014860:Warts / Q000382:microbiology
D004279:DNA, Viral