Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus.
The transient activation of the N-methyl-D-aspartate (NMDA) receptor system by high frequency (tetanic) stimulation results in a rapidly developing and long-lasting potentiation of synaptic transmission in the CA1 region of the hippocampus. This potentiation can be divided into an early decremental component, known as short-term potentiation (STP), and a more slowly developing persistent phase, termed long-term potentiation (LTP). Here we describe how activation of metabotropic glutamate receptors (mGluRs), by aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD), can induce the same stable form of LTP, but without the STP component. 1S,3R-ACPD-induced LTP does not require electrical stimulation during its induction, but is dependent on an intact connection between the CA3 and CA1 regions of the hippocampus. 1S,3R-ACPD-induced LTP circumvents the need for the activation of NMDA receptors and is likely to involve both the stimulation of protein kinase C (PKC) and the release of Ca2+ from intracellular stores.
Department of Pharmacology, Medical School, University of Birmingham, U.K.
Z A
ZA
Bortolotto
G L
GL
Collingridge
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D009473:Neuronal Plasticity / Q000187:drug effects*; D010716:Phosphatidylinositols / Q000502:physiology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D017470:Receptors, Glutamate / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D019311:Staurosporine; D013237:Stereoisomerism; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D013729:Terpenes / Q000494:pharmacology; D019284:Thapsigargin
D000470:Alkaloids; D010716:Phosphatidylinositols; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D013729:Terpenes; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D019284:Thapsigargin; D011493:Protein Kinase C; D000252:Calcium-Transporting ATPases; D019311:Staurosporine