emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6.
The emb-5 gene is required for the correct timing of division of gut precursor cells during gastrulation in Caenorhabditis elegans. We have now characterized the molecular structure of emb-5. The predicted emb-5-encoded protein (EMB-5) possesses an extremely acidic amino-terminus and overall similarity to the Saccharomyces cerevisiae nuclear protein SPT6, which has been shown to affect the transcription of a variety of genes and suggested to play a role in chromatin assembly or modification. EMB-5 may function in the control of cell cycle timing by modulating chromatin structure and consequently affects morphogenesis of C. elegans.
Fundamental Research Laboratories, NEC Corporation, Tsukuba, Japan.
K
K
Nishiwaki
T
T
Sano
J
J
Miwa
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics*; D002455:Cell Division / Q000235:genetics; D002874:Chromosome Mapping; D016386:Chromosome Walking; D004252:DNA Mutational Analysis; D004251:DNA Transposable Elements; D005260:Female; D005656:Fungal Proteins / Q000235:genetics; D005775:Gastrula / Q000166:cytology*; D005800:Genes, Fungal; D017238:Genes, Helminth; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics*; D056488:Histone Chaperones; D007422:Intestines / Q000196:embryology; D008297:Male; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009687:Nuclear Proteins / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*; D035602:Transcriptional Elongation Factors; D014170:Transformation, Genetic
D004251:DNA Transposable Elements; D005656:Fungal Proteins; D015801:Helminth Proteins; D056488:Histone Chaperones; D009687:Nuclear Proteins; C065456:SPT6 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D035602:Transcriptional Elongation Factors