Expression of EBV/C3d receptors on T cells: biological significance.
There is overwhelming evidence that a single polypeptide serves as a receptor for both the Epstein-Barr Virus (EBV), and for certain enzymatic fragments of C3. This receptor, termed CR2 (CD21), is known to be expressed on the surfaces of B cells, and a large body of evidence suggests that CR2, or related structures, are also expressed on cells of the T lineage. Here, Constantine Tsoukas and John Lambris review the studies of CR2 expression in T cells and offer some speculation on its possible biological significance.
Dept of Biology, San Diego State University, CA 92182.
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D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism / Q000382:microbiology; D004854:Herpesvirus 4, Human / Q000378:metabolism*; D006801:Humans; D017464:Receptors, Complement 3d / Q000096:biosynthesis*; D011991:Receptors, Virus / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000378:metabolism / Q000382:microbiology*; D014412:Tumor Virus Infections / Q000276:immunology / Q000378:metabolism
D017464:Receptors, Complement 3d; D011991:Receptors, Virus