Reaction of 1-aminophthalazines with alpha-halocarbonyl compounds: imidazo[2,1-a]phthalazines and their benzodiazepine receptor activities.
The one-pot synthesis and the benzodiazepine receptor binding activity of some imidazo[2,1-a]phthalazines bearing different substituents at position-2 and/or 3 and/or 6 is reported. The dissimilar binding results of the reported compounds are discussed in relation to the nature and/or position of the substituents on the tricyclic ring system.
Catarzi
D
D
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
Cecchi
L
L
Colotta
V
V
Conti
G
G
Melani
F
F
Filacchioni
G
G
Martini
C
C
Giusti
L
L
Lucacchini
A
A
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002417:Cattle; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005445:Flunitrazepam / Q000378:metabolism; D007093:Imidazoles / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D010793:Phthalazines / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011963:Receptors, GABA-A / Q000187:drug effects*
D007093:Imidazoles; D010793:Phthalazines; D011963:Receptors, GABA-A; D005445:Flunitrazepam