Major histocompatibility complex class I deficiency prolongs islet allograft survival.
Because of islet allograft rejection, nonimmunosuppressed pancreatic islet allotransplantation has been unsuccessful for the treatment of type I diabetes. The role of major histocompatibility complex class I antigen expression on islet allograft survival was evaluated with the use of mice homozygous for a beta 2-microglobulin gene disruption. These mice express little if any functional major histocompatibility complex class I antigen. When these major histocompatibility complex class I-deficient islets were used as donors in an allogenic murine transplantation model, islet allograft survival was markedly prolonged. These results demonstrate a major importance for the alloresponse directed against major histocompatibility complex class I antigen.
Osorio
R W
RW
Department of Surgery, University of California, San Francisco 94143.
Ascher
N L
NL
Jaenisch
R
R
Freise
C E
CE
Roberts
J P
JP
Stock
P G
PG
D000818:Animals; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006085:Graft Survival / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D006720:Homozygote; D007154:Immune System Diseases / Q000378:metabolism; D016381:Islets of Langerhans Transplantation / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008954:Models, Biological; D014184:Transplantation, Homologous; D001613:beta 2-Microglobulin / Q000235:genetics / Q000502:physiology
D015395:Histocompatibility Antigens Class I; D001613:beta 2-Microglobulin