Incidence of autoimmune disease in patients after breast reconstruction with silicone gel implants versus autogenous tissue: a preliminary report.
OBJECTIVE
To test the hypothesis that there is a higher incidence of autoimmune disorders in patients who have undergone breast reconstruction with silicone gel implants rather than autogenous tissue.


METHODS
Prospective study.


METHODS
Tertiary referral center dealing exclusively with cancer.


METHODS
All female breast cancer patients who underwent breast reconstruction between January 1986 and March 1992. Patients were nonrandomly assigned to breast reconstruction with one of the following four methods: (1) silicone gel implant only, (2) latissimus dorsi flap with implant, (3) latissimus dorsi flap without implant, and (4) transverse rectus abdominis flap. The first two groups made up the implant cohort and the last two groups the autogenous tissue cohort. Selection of reconstructive method was made on clinical grounds and was based on both physician and patient preference.


METHODS
Documented diagnosis of autoimmune disorder by Board-certified rheumatologist.


RESULTS
Three hundred eight implants were used in 250 patients, and 408 reconstructions with tissue were performed on 353 patients. The two groups were similar in age and tumor stage. The two groups contributed 615.8 and 663.4 person-years of follow-up, respectively. One patient from each group (< 0.5%) had a documented occurrence of an autoimmune syndrome requiring therapy. Both cases were considered mild, and after initial low-dose steroid therapy, both patients are now off steroids.


CONCLUSIONS
The incidence of autoimmune disease in mastectomy patients receiving silicone gel implants is not different than in patients who had reconstruction with autogenous tissue.
Department of Reconstructive and Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston 77030.
M A
MA
Schusterman
S S
SS
Kroll
G P
GP
Reece
M J
MJ
Miller
N
N
Ainslie
S
S
Halabi
C M
CM
Balch
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000209:etiology*; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery; D003240:Connective Tissue Diseases / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D009367:Neoplasm Staging; D011111:Polymyalgia Rheumatica / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D011446:Prospective Studies; D019736:Prostheses and Implants; D012828:Silicones; D013524:Surgical Flaps; D015625:Tissue Expansion Devices
D005782:Gels; D012828:Silicones