Haemopoietic activity associated with biglycan like proteoglycan.
One of the monocytic cell colony stimulating factors produced by thymic myoid cells, a 100 kDa factor, was purified by reversed phase HPLC and found to be homologous to the secreted form of proteoglycan 1 (biglycan) core protein. This biglycan associated colony stimulating factor did not carry an immunological motif of macrophage colony stimulating factor (M-CSF), but predominantly stimulated the proliferation and differentiation of monocytic lineage cells from bone marrow cells, nonadherent thymic cells and peritoneal exudate cells.
National Institute of Neuroscience, NCNP, Tokyo, Japan.
I
I
Kamo
A
A
Kikuchi
I
I
Nonaka
E
E
Yamada
J
J
Kondo
D000595:Amino Acid Sequence; D000818:Animals; D058578:Biglycan; D001853:Bone Marrow; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003115:Colony-Stimulating Factors / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D016326:Extracellular Matrix Proteins; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D008969:Molecular Sequence Data; D011509:Proteoglycans / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
C546884:BGN protein, human; D058578:Biglycan; D003115:Colony-Stimulating Factors; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans; D011994:Recombinant Proteins; C083117:biglycan associated colony-stimulating factor; D016173:Macrophage Colony-Stimulating Factor