Vasoactive properties of a parathyroid hormone-related protein in the rat aorta.
Parathyroid hormone-related protein (PTHrP) or its mRNA transcripts have been documented in a variety of normal tissues, including vascular smooth muscle. A synthetic amino-terminal fragment of PTHrP, PTHrP(1-34), was tested a) for its vasoactive properties in a perfused rat aorta and b) its ability to stimulate cAMP accumulation in cultured rat aorta smooth muscle cells; PTHrP(1-34) was a potent vasodilator and increased cAMP accumulation. The results confirm the potent vasorelaxant properties of PTHrP(1-34), and show that the peptide stimulates adenylate cyclase in vascular smooth muscle cells per se, suggesting, but not proving, linkage of cAMP accumulation to vasorelaxation.
Crass
M F
MF
Department of Physiology, Texas Tech University Health Sciences Center, Lubbock 79430.
Scarpace
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PJ
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D010281:Parathyroid Hormone / Q000494:pharmacology* / Q000502:physiology; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; C054296:parathyroid hormone-related protein (1-34); D000242:Cyclic AMP