[The combination effects of quercetin with the herbicides atrazine, cyanazine and gesamprim in mutagenicity tests].
The plant flavonol quercetin and the triazine herbicides atrazine, cyanazine, and gesamprim were examined individually and in combination for the induction of genotoxic effects. The sister chromatid exchange (SCE) assay and the gene mutation assay for 6-thioguanine resistance (HPRT) were carried out with Chinese hamster ovary (CHO) cells. Whereas no evidence of an increased SCE rate was found, the test substances caused a slightly increased mutation rate in the HPRT assay after metabolic activation with a subcellular liver enzyme preparation. Combination studies with two or three of the test substances did not result in higher mutation rates than those observed for the individual compounds tested singly.
Guigas
C
C
Institut für Hygiene und Toxikologie, Bundesforschungsanstalt für Ernährung, Karlsruhe.
Pool-Zobel
B L
BL
Diehl
J F
JF
D000818:Animals; D001280:Atrazine / Q000633:toxicity*; D016466:CHO Cells; D006224:Cricetinae; D004347:Drug Interactions; D006540:Herbicides / Q000633:toxicity*; D009152:Mutagenicity Tests; D011794:Quercetin / Q000633:toxicity*; D012854:Sister Chromatid Exchange; D014227:Triazines / Q000633:toxicity*
D006540:Herbicides; D014227:Triazines; D011794:Quercetin; D001280:Atrazine; C007168:cyanazine