Parathyroid hormone and T-cellular immunity in uremic patients in replacement dialytic therapy.
We studied 54 patients in replacement dialytic therapy divided into two groups: Group 1, 26 patients with normal parathyroid hormone (PTH) (10-80 pg/ml): and Group 2, 28 patients with elevated PTH (80-400 pg/ml). Total T lymphocytes, CD4, CD8, and CD4/CD8 ratio were evaluated. We found a reduction of total T lymphocytes in both groups compared with controls. A decrease of CD4 and CD4/CD8 ratio with a rise of CD8 occurred in Group 2 but not in Group 1. In Group 2, PTH presented a linear correlation with CD8 and a reverse correlation with total T cells. CD4, and CD4/CD8 ratio. PTH might act on T-cellular immunity with an immunosuppressive effect from the earlier phases of hyperparathyroidism.
Department of Nephrology, Hospital of Lucca, Italy.
D
D
Angelini
A
A
Carlini
R
R
Giusti
R
R
Grassi
E
E
Mei
I
I
Fiorini
L
L
Mazzotta
A
A
Antonelli
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D002762:Cholecalciferol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology*; D014511:Uremia / Q000097:blood / Q000276:immunology / Q000628:therapy*
D010281:Parathyroid Hormone; D002762:Cholecalciferol