Increased cyclic AMP reduces 5-HT1D receptor-mediated inhibition of [3H]5-hydroxytryptamine release from guinea-pig cortical slices.
This study investigated the role of cyclic AMP in the inhibition of [3H]5-hydroxytryptamine ([3H]5-HT) release mediated through the 5-HT1D autoreceptor using slices of guinea-pig cerebral cortex. Forskolin, dibutyryl-cyclic AMP and rolipram, which increase intracellular cyclic AMP by different mechanisms, all attenuated the inhibitory effect of the autoreceptor agonist 5-carboxamidotryptamine. These results indicate that modulation of cyclic AMP production affects 5-HT1D autoreceptor function.
Biochemical Sciences, Wellcome Research Laboratories, Beckenham, Kent, UK.
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Ormandy
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007211:Indoles / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D020889:Rolipram; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013449:Sulfonamides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D018170:Sumatriptan
D007211:Indoles; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D013449:Sulfonamides; D005576:Colforsin; D012701:Serotonin; D003994:Bucladesine; D018170:Sumatriptan; C047087:5-carboxamidotryptamine; D000242:Cyclic AMP; D020889:Rolipram; D011188:Potassium