Nature and incidence of peripheral nerve syndromes in HIV infection.
Fifty four patients with peripheral nerve syndromes were seen during a 15 month period in a population of about 1500 HIV infected patients at all stages of the disease. Distal symmetrical peripheral neuropathies were seen in 38 of the 54 patients, (11.5% of AIDS patients) and could be distinguished into two forms. The most common (n = 25) was a painful peripheral neuropathy during AIDS, which is distinct clinically and pathologically, having axonal atrophy, and is associated with cytomegalovirus infection at other sites. The 13 non-painful neuropathies seen were more heterogeneous. Lumbosacral polyradiculopathy associated with cytomegalovirus and lymphomatous mononeuritis multiplex occurred in fewer than 1% of AIDS patients. Mononeuropathies were seen in 3% of AIDS patients. No patients with acute or chronic inflammatory demyelinating polyradiculoneuropathies were seen. The annual incidence of neuropathies during the AIDS related complex stage was less than 1%; none were seen in asymptomatic HIV seropositive patients.
Department of Neurology, Westminster Hospital, London.
G N
GN
Fuller
J M
JM
Jacobs
R J
RJ
Guiloff
D000386:AIDS-Related Complex / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D001369:Axons / Q000473:pathology; D003645:Death, Sudden / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006679:HIV Seropositivity / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009460:Neurologic Examination; D010147:Pain Measurement; D010523:Peripheral Nervous System Diseases / Q000145:classification / Q000209:etiology* / Q000473:pathology; D011446:Prospective Studies; D012678:Sensation Disorders / Q000145:classification / Q000209:etiology / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D013577:Syndrome