Concurrent oral cytomegalovirus and herpes simplex virus infection in association with HIV infection. A case report.
Recurrent oral herpes simplex virus lesions are common in both immunocompetent and immunocompromised persons. In contrast, cytomegalovirus-associated intraoral lesions are rarely seen, even in the immunocompromised host. We report a case of concurrent oral herpes simplex virus and cytomegalovirus infection, appearing as an ulcerative lesion of the labial mucosa in a patient with acquired immunodeficiency syndrome. Herpes simplex virus type 1 was shown to be present in the lesion by culture tests, histopathologic examination, immunohistochemistry findings and a direct immunofluorescence assay, and cytomegalovirus by histopathologic examination and immunohistochemistry findings. We deduce that the lesion was due to concurrent herpes simplex virus-1 and cytomegalovirus infection. The patient responded well to 2 weeks of treatment with a high dose of acyclovir.
Department of Stomatology and Oral AIDS Center, University of California, San Francisco.
G S
GS
Heinic
D W
DW
Northfelt
J S
JS
Greenspan
L A
LA
MacPhail
D
D
Greenspan
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology; D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000911:Antibodies, Monoclonal; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008047:Lip Diseases / Q000382:microbiology; D008297:Male; D009059:Mouth Diseases / Q000382:microbiology*; D009061:Mouth Mucosa / Q000382:microbiology / Q000473:pathology; D018139:Simplexvirus / Q000302:isolation & purification; D013281:Stomatitis, Aphthous / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D013283:Stomatitis, Herpetic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015163:Superinfection
D000911:Antibodies, Monoclonal; D000212:Acyclovir