Spontaneous degradation via diketopiperazine formation of peptides containing a tetrahydroisoquinoline-3-carboxylic acid residue in the 2-position of the peptide sequence.
Marsden
B J
BJ
Laboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal, Quebec, Canada.
Nguyen
T M
TM
Schiller
P W
PW
D000595:Amino Acid Sequence; D004355:Drug Stability; D007546:Isoquinolines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010879:Piperazines / Q000737:chemistry; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors
D007546:Isoquinolines; D009842:Oligopeptides; D010879:Piperazines; D017465:Receptors, Opioid, delta