Genetic mapping of three GABAA receptor-subunit genes in the mouse.
GABAA receptors are a heterogeneous group of heterooligomeric ligand-gated anion channels that represent the main means of synaptic inhibition in neuronal tissue. At least 14 distinct GABAA subunit proteins representing 5 different classes have been identified. Using rat brain cDNAs for the GABAA receptor beta 1-, alpha 2-, and alpha 4-subunits, we have assigned the corresponding murine genes Gabrb-1, Gabra-2, and Gabra-4 to specific chromosomes with somatic cell hybrids, and we have positioned these genes by analysis of the progeny of three genetic crosses. Gabrb-1 and Gabra-2 are tightly linked on mouse Chromosome 5 between the markers Pgm-1 and Kit, and Gabra-4 maps to proximal mouse Chromosome 7 in apparent proximity to the previously mapped Gabrb-3. The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse "circling mutation" pi (pirouette).
Jules Stein Eye Institute, UCLA School of Medicine.
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M
Danciger
D B
DB
Farber
C A
CA
Kozak
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D006822:Hybrid Cells; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice / Q000235:genetics*; D008807:Mice, Inbred BALB C / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics; D009115:Muridae / Q000235:genetics; D011963:Receptors, GABA-A / Q000235:genetics*; D011995:Recombination, Genetic
D011963:Receptors, GABA-A