Induction of malignant fibrous histiocytoma in female Fisher rats by implantation of cyanoacrylate, zirconia, polyvinyl chloride or silicone.
Five kinds of foreign bodies (silicone, cellulose, polyvinyl chloride, zirconia and alkyl-alpha cyanoacrylate) were implanted into subcutaneous tissue of female Fisher rats. Subcutaneous tumors were induced in 27.3, 54.5, 100, 63.6% of rats by silicone rubber, polyvinyl chloride, zirconia and alkyl-alpha-cyanoacrylate, respectively, but not by cellulose. Almost all tumors were composed of a mixture of cells that resembled fibroblasts characterized by the presence of numerous rough-surfaced endoplasmic reticulum and Golgi apparatus, histiocytes characterized by developed endoplasmic reticulum and abundant lysosome, myofibroblasts characterized by the presence of both myofibrils and fibroblast-like structures, and immature mesenchymal cells. In some tumors, the cells exhibited a storiform pattern. Some tumor cells were positively stained by ED2 or anti-muscle actin antibody. The features of induced tumors in rats were consistent with those of human malignant fibrous histiocytoma. A rat malignant fibrous histiocytoma transplanted into the subcutaneous tissue of the syngeneic female Fisher rats grew and metastasized to the lungs.
Department of Pathology, Faculty of Medicine, Kagoshima University, Japan.
S
S
Hatanaka
S
S
Oneda
K
K
Okazaki
L J
LJ
Shong
A
A
Yoshida
H
H
Isaka
H
H
Yoshida
D000818:Animals; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000139:chemically induced* / Q000473:pathology; D011143:Polyvinyl Chloride / Q000008:administration & dosage*; D051381:Rats; D011916:Rats, Inbred F344; D012828:Silicones / Q000008:administration & dosage*; D015040:Zirconium / Q000008:administration & dosage*
D003487:Cyanoacrylates; D004343:Drug Implants; D012828:Silicones; D011143:Polyvinyl Chloride; D015040:Zirconium; C028541:zirconium oxide