[Intramuscular beta-interferon therapy of patients with genital HPV infection].
From May 1990 to April 1992 we used intramuscular beta-interferon to treat 17 patients with CIN associated with HPV virus (9 cases CIN1 and 8 cases CIN2) and 10 patients with genital condylomas without CIN. The dosage employed was 3.000.000 IU/daily/7 days and every other day for a further 14 days. All patients were followed up at 1,3 and 6 months and some for longer. Complete cyto histological resolution of CIN was achieved in 58% of patients: however the HPV remain cytologically present in 64% of cases. The data presented are encouraging though they confirm that it is difficult to completely eradicated the genital HPV. In patients with genital condyloma the condition persisted in 66% of patients receiving only medical treatment, whereas in those treated with beta-interferon and dyatermocoagulation the recurrence rate was 28%.
Divisione di Ostetricia e Ginecologia, Regione Lombardia, USSL n. 67, Ospedale Santa Corona, Garbagnate Milanese, Milano.
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Sartor
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Spairani
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Gini
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Delpiano
D000328:Adult; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D004564:Electrocoagulation; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D016899:Interferon-beta / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D027383:Papillomaviridae / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery
D016899:Interferon-beta