[The beta-adrenoreceptors of the cerebral cortex in rat pups after exposures altering the noradrenaline level].
Elevation of noradrenaline level in the brain cortex of 7-day old rats induced by prenatal corticosterone administration was accompanied by a decrease in beta-adrenoreceptor density determined by specific [3H]dihydroxyalprenolol binding. Affinity of receptors to the ligand remained unchanged. Injections to 4-6-day old rats of alpha-methyl-p-tyrosine that blocks catecholamine synthesis resulted in a decreased noradrenaline content and increased beta-adrenoreceptor density in the brain cortex of 7-day old rats. The extent of changes in beta-adrenoreceptor density in the brain cortex of 7-day old rats induced by prenatal or postnatal treatment showed negative correlation with changes in noradrenaline level. Thus, noradrenaline down-regulates beta-adrenoreceptor density in the brain cortex during early postnatal development. Such effect of the neurotransmitter can mediate the effect of corticosterone on ontogenesis of beta-adrenoreceptors.
N N
NN
Dygalo
G T
GT
Shishkina
A A
AA
Milova
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003345:Corticosterone / Q000494:pharmacology; D004082:Dihydroalprenolol / Q000378:metabolism; D005260:Female; D008024:Ligands; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000378:metabolism; D019805:alpha-Methyltyrosine
D008024:Ligands; D008781:Methyltyrosines; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D019805:alpha-Methyltyrosine; D003345:Corticosterone; D009638:Norepinephrine