Antidiarrhoeic activity of Euphorbia hirta extract and isolation of an active flavonoid constituent.
The antidiarrhoeic activity of the Euphorbia hirta whole plant was investigated. The lyophilized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by castor oil, arachidonic acid, and prostaglandin E2. It showed no activity when magnesium sulphate was used to provoke the diarrhoea. The lyophilized decoction delayed small intestinal transit when this was accelerated by castor oil but not in normal conditions. A flavonoid, quercitrin, with antidiarrhoeic activity was isolated from this crude drug.
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, Spain.
J
J
Galvez
A
A
Zarzuelo
M E
ME
Crespo
M D
MD
Lorente
M A
MA
Ocete
J
J
Jiménez
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000930:Antidiarrheals; D010936:Plant Extracts; C012526:quercitrin; D011794:Quercetin