Squamous cell cancer of the cervix, immune senescence and HPV: is cervical cancer an age-related neoplasm?
Relationships between cancer and aging will assume greater scientific importance over the coming decades as the number and proportion of elderly increase. Contrary to popular belief, cervical cancer remains an important disease into old age. This paper will briefly review what is known about immune senescence, cervical cancer and immune function, and the relationship between human papilloma virus and immunity, to support the hypothesis that these factors may contribute to the continued occurrence of invasive cervical cancer in the elderly.
Mandelblatt
J
J
Memorial Sloan-Kettering Cancer Center, Division of Cancer Control, New York, New York 10021.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D015897:Comorbidity; D005060:Europe / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D015994:Incidence; D007843:Latin America / Q000453:epidemiology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae / Q000276:immunology / Q000472:pathogenicity*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology