Anesthetic management of a patient with Bartter's syndrome.
Bartter's syndrome is a rare disorder characterized by normal or low arterial blood pressure (BP), despite marked elevation in plasma renin activity, angiotensin II (Ang-II), and aldosterone, along with hypokalemic metabolic alkalosis. Perioperative changes in the cardiovascular and renin-angiotensin-aldosterone (RAA) systems in Bartter's syndrome patients are not well understood. We managed a 44-year-old Japanese man with rectal cancer and Bartter's syndrome complicated by renal dysfunction. He underwent anterior resection of the rectum with general anesthesia (50% nitrous oxide-oxygen with 0.5% to 0.8% isoflurane, supplemented with intravenous midazolam and butorphanol). Epidural morphine was given postoperatively. Although BP tended to be lower (75/35 to 110/60 mmHg) during surgery, there were no profound perioperative hemodynamic derangements. Plasma renin activity. Ang-II, and aldosterone values were highest during surgery. These responses of the RAA system to anesthesia and surgery were the same as previously noted in otherwise healthy surgical patients.
Department of Anesthesiology, School of Medicine, Fukuoka University, Japan.
K
K
Higa
H
H
Ishino
S
S
Sato
K
K
Dan
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000769:Anesthesia, Inhalation; D000804:Angiotensin II / Q000097:blood; D001477:Bartter Syndrome / Q000150:complications*; D006801:Humans; D007530:Isoflurane; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D009609:Nitrous Oxide; D010100:Oxygen; D012004:Rectal Neoplasms / Q000150:complications / Q000601:surgery*; D012083:Renin / Q000097:blood
D000804:Angiotensin II; D000450:Aldosterone; D007530:Isoflurane; D012083:Renin; D009609:Nitrous Oxide; D010100:Oxygen