Netropsin inhibits the increase of intracellular Ca(2+)-dependent serine proteinase activity in sporulating Bacillus megaterium.
Netropsin suppressed the increase of intracellular proteolytic activity when added to B. megaterium incubated in a sporulation medium. The inhibited enzyme was a Ca(2+)-dependent serine proteinase. Sporulation and protein turnover in later sporulation phases were inhibited as well. Different concentrations of netropsin affected various aspects of protein catabolism differently.
Kucerová
H
H
Department of Cell and Molecular Microbiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.
Chaloupka
J
J
D001410:Bacillus megaterium / Q000187:drug effects / Q000201:enzymology*; D002118:Calcium / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D009024:Morphogenesis / Q000187:drug effects; D009429:Netropsin / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000096:biosynthesis* / Q000187:drug effects; D013171:Spores, Bacterial / Q000187:drug effects*
D009429:Netropsin; D012697:Serine Endopeptidases; D002118:Calcium