[Glomerular permeability for serum proteins in different morphological types of primary chronic glomerulopathy].
Membranous glomerulonephritis (MGN), mesangiocapillary (MCGN), membranoproliferative glomerulonephritis (MPGN) and focal segmental sclerosis or hyalinosis (FSSH) were studied for glomerular filter permeability to serum albumins, IgA and IgG. In MGN the permeability for large-molecular globulins is not dependent on that for albumin, permeabilities for the globulins appeared correlated. In MPGN permeability for IgG depends on albumins permeability, correlations between that for IgA and IgG are similar to relevant findings in MGN. In MCGN glomerular permeability for IgA depends on that for albumins, and IgG depends on IgA permeability. In FSSH better albumin permeability implies increased permeability for both globulins, while enhanced permeability for IgA entails the same trend for albumins and IgG. Variable permeability of the glomerular filter for serum proteins in different morphological forms of chronic glomerulopathy may result from dissimilar defects in diverse layers of the filter and in interaction of basal membrane structures with cells responsible for glomerular impermeability for serum proteins.
Fedorova
N D
ND
Serov
V V
VV
Alekseevskaia
M A
MA
Varshavskiĭ
V A
VA
Ratner
M Ia
MIa
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism
D001798:Blood Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012709:Serum Albumin