Chronic demyelinating neuropathy and intra-axonal polyglucosan bodies.
In this study we evaluated the relationship between polyglucosan bodies and peripheral nerve lesions. The biopsied sural nerve from a patient with late-onset chronic sensori-motor neuropathy showed many intra-axonal polyglucosan bodies and segmental demyelination/remyelination. The formation of Schwann cell hyperplasia around the demyelinated axons was found at the sites of polyglucosan bodies. These findings suggest that demyelinating neuropathy is a part of the spectrum of the diseases characterized by the accumulation of polyglucosan bodies within cellular compartments.
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
K
K
Matsumuro
S
S
Izumo
Y
Y
Minauchi
M
M
Inose
I
I
Higuchi
M
M
Osame
D000368:Aged; D001369:Axons / Q000648:ultrastructure*; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000378:metabolism / Q000473:pathology*; D005936:Glucans / Q000378:metabolism*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D012583:Schwann Cells / Q000648:ultrastructure; D013497:Sural Nerve / Q000473:pathology
D005936:Glucans; C083094:polyglucosan