[Evaluation of factors aggravating and delaying recovery from postoperative hypercoagulable state in patients operated on for esophageal cancer].
When a living body is invaded to a high degree, a hypercoagulable state develops. The radical operation for esophageal cancer is known as a very high risk operation. The purpose of this study is to evaluate in detail the postoperative changes in platelet, coagulation and fibrinolytic systems, in 34 patients operated on for esophageal cancer, and to clarify the factors contributing to both the aggravation and delay of recovery from the postoperative hypercoagulable state. Operating time and blood loss during surgery were factors aggravating the postoperative hypercoagulable state. The mechanism of coagulation progressed significantly in those patients requiring 500 minutes or more operating time and having a blood loss of 600 ml or more during surgery. Age was seen as an important factor delaying recovery, as the recovery of the coagulative parameters was delayed significantly in patients aged 70 or above. Hepatic function was the most important of post operative organ functions. Renal, cardiac and respiratory functions were unrelated to the postoperative hypercoagulable state.
First Department of Surgery, Fukusima Medical College, Japan.
M
M
Takahara
A
A
Usuba
G
G
Endou
A
A
Konno
M
M
Toyama
H
H
Suzuki
O
O
Konno
H
H
Inoue
R
R
Motoki
D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical; D004938:Esophageal Neoplasms / Q000097:blood* / Q000601:surgery; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011184:Postoperative Period