Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients.
Serum thrombomodulin (sTM) is an endothelial cell marker which would reflect the endothelial damage. In order to examine whether some antiplatelet agents decrease the endothelial damage in diabetic patients, sTM concentrations were measured by enzyme-linked immunosorbent assay before and after oral administration of a daily 100 mg of cilostazol for 4 weeks in 9 diabetics or a daily 81 mg of acetyl salicylic acids (ASA) for 4 weeks in 8 diabetics. Basal concentrations of sTM were elevated in most of these patients as compared with healthy subjects. The sTM concentrations were decreased after administration of cilostazol from 28.1 +/- 7.1 ng/ml to 23.6 +/- 5.4 ng/ml (p < 0.01), and after ASA from 30.7 +/- 10.9 ng/ml to 27.9 +/- 11.6 ng/ml (p < 0.05). These results suggest that such drugs can decrease the endothelial damage, resulting in the reduced risk of diabetic vascular complications.
First Department of Internal Medicine, Niigata University School of Medicine, Japan.
N
N
Tani
K
K
Hada
A
A
Kitami
M
M
Nakano
H
H
Takahashi
S
S
Ito
I
I
Sato
A
A
Shibata
D000368:Aged; D001241:Aspirin / Q000494:pharmacology*; D000077407:Cilostazol; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000032:analysis*; D018179:Receptors, Thrombin; D013777:Tetrazoles / Q000494:pharmacology*
D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; D013777:Tetrazoles; D000077407:Cilostazol; D001241:Aspirin