The effect of the fiber components cellulose and lignin on experimental colon neoplasia.
Sixty Sprague-Dawley rats were pair-fed one of three nutritionally identical diets. One diet contained "low-fiber" (3.8% crude fiber); the others contained "high fiber" (28.7% crude fiber) composed of either cellulose or lignin. Although both "high fiber" diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in 1,2-dimethylhydrazine (DMH)-induced colon neoplasms. The cellulose diet was also associated with distinct changes in the gut bacterial profile and with a lowered serum cholesterol.
Sloan
D A
DA
Department of Surgery, University of Kentucky College of Medicine, Lexington.
Fleiszer
D M
DM
Richards
G K
GK
Murray
D
D
Brown
R A
RA
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens; D002482:Cellulose / Q000627:therapeutic use*; D003106:Colon / Q000382:microbiology; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000178:diet therapy* / Q000382:microbiology; D004043:Dietary Fiber / Q000627:therapeutic use*; D004127:Dimethylhydrazines; D005243:Feces / Q000382:microbiology; D008031:Lignin / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D004043:Dietary Fiber; D004127:Dimethylhydrazines; D002482:Cellulose; D008031:Lignin; D019813:1,2-Dimethylhydrazine