Genetics of a multifactorial disease: autoimmune type 1 diabetes mellitus.
1. Three non-major histocompatibility complex genes, Idd-3, Idd-4 and Idd-5, that influence the onset of autoimmune type 1 diabetes in the non-obese diabetic mouse have been located on chromosomes 3, 11 and 1. 2. In undertaking this study, a new map of the mouse genome has been created from polymerase chain reaction-analysable mouse microsatellite markers. 3. The homologues of these genes may reside on human chromosomes 1 or 4 (Idd-3), 17 (Idd-4) and 2q (Idd-5).
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, U.K.
R J
RJ
Cornall
D000818:Animals; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD / Q000235:genetics*; D017385:Sequence Homology
D005819:Genetic Markers