Mutagenesis by 8-oxoguanine: an enemy within.
The presence of reactive oxygen species in cells ensures that the oxidatively damaged base 8-oxoguanine will be generated at high frequency in the DNA of all living organisms. DNA damage threatens genomic integrity: enzymes have evolved that protect prokaryotes and eukaryotes from the mutagenic effect of this ubiquitous lesion.
Department of Pharmacological Sciences, State University of New York, Stony Brook 11794-8651.
A P
AP
Grollman
M
M
Moriya
D004249:DNA Damage; D045647:DNA Glycosylases; D004260:DNA Repair / Q000502:physiology*; D043382:DNA-Formamidopyrimidine Glycosylase; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins; D006147:Guanine / Q000031:analogs & derivatives* / Q000502:physiology; D016296:Mutagenesis; D009699:N-Glycosyl Hydrolases / Q000502:physiology; D017382:Reactive Oxygen Species
D029968:Escherichia coli Proteins; D017382:Reactive Oxygen Species; C024829:8-hydroxyguanine; D006147:Guanine; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; C061738:mutY adenine glycosylase; D043382:DNA-Formamidopyrimidine Glycosylase; C468610:DNA-formamidopyrimidine glycosylase, E coli