Two new 2-arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis.
Ethyl acetate- and n-butanol-soluble fractions of the leaves of Morus insignis showed a significant hypoglycemic activity on streptozotocin (STZ)-induced hyperglycemic rats. From these hypoglycemic activity-showing fractions, two new compounds, mulberrofuran U (2) and moracin M-3-O-beta-D-glucopyranoside (3) were isolated, along with six known compounds [beta-sitosterol, beta-sitosterol-3-O-beta-glucopyranoside, ursolic acid, moracin M (1), kaempferol-3-O-beta-glucopyranoside and quercetin-3-O-beta-glucopyranoside] and the structures of the new compounds were determined by spectroscopic and chemical methods.
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
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D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002675:Child, Preschool; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology; D013267:Stilbenes
D001572:Benzofurans; D001786:Blood Glucose; D005960:Glucosides; D007004:Hypoglycemic Agents; D012118:Resorcinols; D013267:Stilbenes; C083338:moracin M-3'-O-glucopyranoside; C083337:mulberrofuran U