[Pathogenetic significance of endothelin in experimental liver necrosis].
The changes in rat plasma level of endothelin-ir (ET-ir) during CCl4-induced hepatic necrosis and the therapeutic action of ET-antiserum (ET-Ab) were observed. The plasma level of ET-ir in rats with liver necrosis was significantly elevated (17.7 +/- 2.6 ng/L vs control 9.5 +/- 1.6 ng/L, P < 0.05). The plasma level of ET was markedly decreased by using ET-Ab, simultaneously the calcium overload in liver attenuated, the formation of liver lipid peroxidation product decreased, and activities of plasma ALT and LDH were also reduced. The results indicate that ET-Ab effectively alleviated the CCl4-induced damage to liver, and suggest that ET might be one of important humoral factors involved in liver necrosis.
Chen
Y X
YX
Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000473:pathology* / Q000628:therapy; D016232:Endothelins / Q000097:blood* / Q000276:immunology; D007116:Immunization, Passive; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009336:Necrosis; D011817:Rabbits; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar
D016232:Endothelins; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase