Inhibition of methyl mercury chloride-induced chromosomal damage by gamma-linolenic acid.
The genotoxic potential of methyl mercury chloride (MMC) was investigated in human lymphocyte cultures by tests for chromosomal aberrations and sister chromatid exchange. The protective role of gamma-linolenic acid, a derivative of dietary essential fatty acid, on MMC-induced genetic damage was evident from the reduced frequency of aberrations and sister chromatid exchanges.
Bala
K V
KV
Department of Genetics, Osmania University, Hyderabad, India.
Sridevi
K
K
Rao
K P
KP
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008042:Linolenic Acids / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D008677:Metaphase / Q000187:drug effects; D008767:Methylmercury Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity; D012854:Sister Chromatid Exchange / Q000187:drug effects; D017965:gamma-Linolenic Acid
D008042:Linolenic Acids; D008767:Methylmercury Compounds; D017965:gamma-Linolenic Acid; C004925:methylmercuric chloride