A model of the factors affecting interstitial volume in oedema. Part II: Their effects at various abnormal steady-states.
A mathematical model has been used to investigate the alterations, in amount and importance, of the Factors controlling interstitial fluid volume in a number of steady-state oedemas. Steady-states were used because it is much easier to evaluate the effect of a specific Factor on oedema if all the others are constant. They are best compared if expressed in the same units: ml/min/100 g of tissue. The effects of lymphatic drainage on trauma are very important, as is the effect of tissue proteolysis on lymphoedema. Tissue proteolysis has minimal effects on the normal state and trauma; yet modelling its increase with benzo-pyrones markedly reduces oedema in both trauma and lymphoedema. Excess fibrosis greatly reduces lymphoedema. The effects of the individual Factors vary considerably between the different steady-states.
Henry Thomas Laboratory, University of Adelaide, Australia.
J R
JR
Casley-Smith
D004487:Edema / Q000378:metabolism / Q000503:physiopathology*; D005110:Extracellular Space / Q000378:metabolism / Q000502:physiology*; D005355:Fibrosis; D006801:Humans; D006868:Hydrolysis; D008209:Lymphedema / Q000378:metabolism; D008433:Mathematics; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism
D011506:Proteins