[The formation of a pathological system in rats with neuropathic trigeminal neuralgia].
The intensity of clinical manifestations (rubbing of the oro-facial area with skin injury), bioelectric activity of the somatosensory cortex and microcirculatory disturbances were studied for 6 weeks in Wistar rats with partial infraorbital nerve compression. These parameters were compared among rats of the following groups: without skin rubbing (1), with them (2), with repaired skin (3) after nerve compression and sham-operated rats (4). A correlation between the intensity of clinical manifestations and microcirculatory disturbances was shown. Epileptiform cortex activity was observed in 100% and 75% rats of the 2nd and 3rd groups, respectively, while in group 1 this per cent decreased time. These results are discussed with regard to the formation of pathologic algic system which underlies the pain syndrome and affects peripheral target organs.
Kryzhanovskiĭ
G N
GN
Dolgikh
V G
VG
Gorizontova
M P
MP
Mironova
I V
IV
D000818:Animals; D004558:Electric Stimulation; D008297:Male; D008442:Maxillary Nerve / Q000503:physiopathology; D008643:Mesentery / Q000098:blood supply; D008833:Microcirculation / Q000503:physiopathology; D009408:Nerve Compression Syndromes / Q000150:complications / Q000503:physiopathology; D009915:Orbit / Q000294:innervation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000503:physiopathology; D013003:Somatosensory Cortex / Q000503:physiopathology; D013997:Time Factors; D014277:Trigeminal Neuralgia / Q000209:etiology / Q000503:physiopathology*