A plasma membrane redox system in human retinoblastoma cells.
Y79 human retinoblastoma cells have a high capacity to reduce ascorbate autooxidation rates through the reduction of the ascorbate free radicals generated in the oxidation process. Responsible of this capacity is a plasma membrane redox system, which might be functionally related to the Na+/H+ antiporter. Ascorbate has cytotoxic effect on Y79 cells in long-term incubations in the presence of limited amounts of serum in the medium.
Sektion Onkologie/Immunologie, Ruprecht-Karls-Universität, Heidelberg, FRG.
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MA
Medina
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Schweigerer
D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010084:Oxidation-Reduction; D012175:Retinoblastoma / Q000378:metabolism* / Q000473:pathology; D017923:Sodium-Hydrogen Exchangers; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D005609:Free Radicals; D017923:Sodium-Hydrogen Exchangers; D009247:NADH, NADPH Oxidoreductases; C014227:ferricyanide reductase; D001205:Ascorbic Acid