[Herbal decoction of qingwen baidu yin in treating endotoxic fever in rabbits].
Qingwen Baidu Yin (QBY) has good curative effects on the endotoxic fever of rabbits induced by injecting endotoxin of E. Coli. The test group was given QBY orally, while the control group was given NS orally instead. Result showed QBY could: (1) Markedly inhibit the fever, it was effective in reducing febrile curve. delta T and TRI5 of the test group were smaller (P < 0.001). (2) Ameliorate the leukocytopenia and leukocytosis, and improve thrombocytopenia. (3) Antagonize hyperviscosity syndrome and had the actions of depolymerization and dilution. (4) In test group, the increased cAMP content in plasma was reduced, and the decreased cGMP content raised, the ratio of cAMP and cGMP was nearly normal. All these provided the clue in elucidating the essence of "Excessive Yang causes Heat" and "Predominance of Yang leads to disorder of Yin". (5) Pathomorphological examination showed that QBY had the functions of protecting the internal organs and reducing the organic damage induced by endotoxing in rabbits.
Hangzhou Hospital of TCM.
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D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D005334:Fever / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D011817:Rabbits; D016710:Yin Deficiency / Q000139:chemically induced / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D000242:Cyclic AMP; D006152:Cyclic GMP