[Major hypercalcemia disclosing sarcoidosis].
Sarcoidosis is exceptionally revealed by major isolated hypercalcemia. To the 4 cases already published, we are adding this one. A review of the literature is presented, focussed on the frequency and characteristic features of the hypercalcemia associated with sarcoidosis, as well as its physiopathology: an overproduction by granulomatous cells of 1-25 dihydroxyvitamin D3 evading the usual regulatory mechanisms. Treatment rests on corticosteroid therapy and sometimes hydroxychloroquine.
Service de Rhumatologie, CHR Nantes, Hôpital Saint-Jacques.
C
C
Mathis
Y
Y
Maugars
P
P
Vilon
A
A
Prost
D002117:Calcitriol / Q000097:blood; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology
D002117:Calcitriol