Foscarnet treatment in various cytomegalovirus infections.
We examined the effect of foscarnet (Foscavir) in 15 AIDS patients with cytomegalovirus infection. Cytomegalovirus infection was presented as retinits (n = 8), colitis (n = 3), oral (n = 1) and perianal ulcers (n = 3) and pneumonitis (n = 1). Induction therapy with foscarnet showed a complete response in 9 and a partial response in 6 patients after a medium therapy of 3.5 weeks. Three patients showed progressive disease under ganciclovir and were treated subsequently with foscarnet. Main side effects were ulcers of the glans penis (n = 6) and a rise of creatinine (> 1.5 mg/dl; n = 4). Therapy was changed to ganciclovir because of renal toxicity in 1 patient receiving induction therapy with foscarnet. Within a period of foscarnet therapy between 5 and 9 months (median: 7 months) no clinical progression occurred. Medium survival after diagnosis of cytomegalovirus infection was 7.4 months. We describe our experience with foscarnet and compare treatment results of cytomegalovirus infection at certain locations.
Department of Dermatology, University of Essen, Germany.
N H
NH
Brockmeyer
U R
UR
Hengge
L
L
Mertins
R
R
Malessa
R
R
Steinmetz
M
M
Gooss
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D003092:Colitis / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D015828:Eye Infections, Viral / Q000188:drug therapy; D005401:Fissure in Ano / Q000188:drug therapy; D017245:Foscarnet / Q000009:adverse effects / Q000627:therapeutic use*; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012173:Retinitis / Q000188:drug therapy; D013281:Stomatitis, Aphthous / Q000188:drug therapy
D017245:Foscarnet; D015774:Ganciclovir