A comparison of the iron-clearing properties of parabactin and desferrioxamine.
A comparative study of the iron-clearing properties of subcutaneously administered desferrioxamine and parabactin is presented. The evaluation was performed in both a non-iron-overloaded bile-duct cannulated rat and an iron-loaded Cebus monkey model. Parabactin was superior to desferrioxamine in both the rodent and the primate. Unlike desferrioxamine, nearly all of the parabactin-induced iron clearance occurred in the bile. This study represents an evaluation of the iron-clearing properties of parabactin, a hexacoordinate catecholamide siderophore.
Department of Medicinal Chemistry, University of Florida, Gainesville 32610.
R
R
Bergeron
R R
RR
Streiff
W
W
King
R D
RD
Daniels
J
J
Wiegand
D000818:Animals; D002428:Cebus; D003676:Deferoxamine / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D007502:Iron Chelating Agents; D010080:Oxazoles; C042991:parabactin; D007501:Iron; D003676:Deferoxamine