Effect of nifedipine administration on the functional capacity of neutrophils.
Administration of nifedipine to mice over a period of six months caused a significant (p < 0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt. Properties like chemotaxis and phagocytosis showed a similar decrease. From this study, it is seen that nifedipine causes neutrophil functional abrogation which is therefore an apparent concern for the prolonged usage of the drug. However, relevance of the mouse model to clinical situation needs further investigation.
Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
N
N
Kaul
K I
KI
Andrabi
N K
NK
Ganguly
P L
PL
Wahi
D000818:Animals; D002634:Chemotaxis, Leukocyte; D008297:Male; D051379:Mice; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D009249:NADP / Q000096:biosynthesis; D019255:NADPH Oxidases; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D010587:Phagocytosis; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D009249:NADP; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D009543:Nifedipine