The habenula and pain: repeated electrical stimulation produces prolonged analgesia but lesions have no effect on formalin pain or morphine analgesia.
Recent studies have found that electrical stimulation of the habenula or microinjection of morphine into it reduces pain in several pain tests. The present study explored additional properties of the habenula. Expt. 1 examined the influence of the duration of stimulation on the duration of poststimulation analgesia in the formalin test. Expt. 2 was carried out to determine whether destruction of the habenula would affect either baseline pain levels or analgesia produced by morphine administered systemically in the formalin test. The results showed that the duration of analgesia is related to the duration of electrical stimulation. However, habenular lesions did not affect baseline pain levels or morphine analgesia. These studies support earlier evidence that manipulation of the habenula can produce analgesia, but suggest that it is not tonically active in modulating pain or necessary for the analgesic effects of systemically administered morphine.
Department of Psychology, McGill University, Montreal, Que., Canada.
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Cohen
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Melzack
D000818:Animals; D001931:Brain Mapping; D004027:Diencephalon / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D005557:Formaldehyde / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000502:physiology*
D011957:Receptors, Opioid; D005557:Formaldehyde; D009020:Morphine