Efficacy of (-)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in African green monkeys infected with simian varicella virus.
(-)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine was evaluated for its efficacy in African green monkeys infected with simian varicella virus. Treatment by intramuscular injection was initiated 48 h after virus inoculation and was continued for 10 days; the treatment showed therapeutic effects on rash and viremia at dosages down to 1 mg/kg of body weight per day.
Tulane Regional Primate Research Center, Covington, Louisiana 70433.
K F
KF
Soike
R
R
Bohm
J L
JL
Huang
B
B
Oberg
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D006147:Guanine; D006564:Herpesviridae; D006566:Herpesviridae Infections / Q000097:blood / Q000188:drug therapy*
D000998:Antiviral Agents; C053539:penciclovir; D006147:Guanine; D000212:Acyclovir