[Assessment of the functional state of microsomal enzymes in the liver in patients with small cell lung cancer treated with cytostatic drugs].
Assessment of the functional state of the liver microsomal enzymes with 14C-aminopyrine breath test (ABT) was performed in 42 patients with small cell lung cancer before treatment (group I), in 30 patients with small cell lung cancer treated with cytostatic drug after remission induction of Houston program (group II) and in 30 healthy volunteers of control group (group III). The classic liver tests were determined. Statistically low values of aminopyrine breath test in patients with advanced cancer (stadium III) were found. Values of ABT decreased further after the cytostatic drugs treatment. Abnormal results were found in 83% of patients in the group II. Values of classic liver tests in whole population (group I, II, III) were within normal limits. Abnormal values of ABT that indicate inhibition of aminopyrine demethylation may indicate early functional hepatocytes lesion after cytostatic treatment. This test should be done previously in patients needing treatment with other metabolised in liver or with microsomal system inhibitors.
Katedra i Klinika Chorób Wewnetrznych i Zawodowych, Zabrzu.
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E
Piotrowska
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Piotrowski
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001944:Breath Tests; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000201:enzymology*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D008875:Middle Aged; D012016:Reference Values
D000970:Antineoplastic Agents