Inositol trisphosphate and calcium signalling.
Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.
Berridge
M J
MJ
AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK.
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D015220:Calcium Channels; D002453:Cell Cycle; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D005260:Female; D005306:Fertilization; D019204:GTP-Binding Proteins / Q000502:physiology; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism / Q000502:physiology*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008297:Male; D008954:Models, Biological; D009473:Neuronal Plasticity; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology; D011950:Receptors, Cholinergic / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear; D012433:Ryanodine / Q000494:pharmacology; D019837:Ryanodine Receptor Calcium Release Channel; D015290:Second Messenger Systems; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic; D018160:Receptors, Cytoplasmic and Nuclear; D019837:Ryanodine Receptor Calcium Release Channel; D012433:Ryanodine; D015544:Inositol 1,4,5-Trisphosphate; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; D002118:Calcium