Ifosfamide neurotoxicity. A challenge for nurses, a potential nightmare for patients.
The alkylator-like agent ifosfamide, which has been found to be useful in the treatment of a number of solid tumors, can have severe central nervous system (CNS) side effects in addition to causing myelosuppression, nephrotoxicity, nausea and vomiting, pulmonary edema, and interstitial pneumonitis. This article, including a case study and a protocol, prepares nurses to do patient education and to observe, assess, and provide care for patients who may experience the CNS toxicity that ranges from mild changes to severe disturbances of mental state.
Cameron
J C
JC
Yale University School of Nursing.
D001927:Brain Diseases / Q000139:chemically induced; D018288:Carcinoma, Small Cell / Q000188:drug therapy; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use* / Q000633:toxicity*; D008175:Lung Neoplasms / Q000188:drug therapy; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000209:etiology
D007069:Ifosfamide