The effect of acarbose on diabetes- and age-related basement membrane thickening in retinal capillaries of the BB/W-rat.
The effect of the alpha-glucosidase inhibitor acarbose on retinal capillary basement membrane thickening was examined in the spontaneously diabetic BB/W-rat. Four months of diabetes resulted in significant thickening of the basement membranes of both the superficial and deep capillary nets of the retina. This characteristic change of the retinal microvasculature in diabetes was completely prevented by acarbose treatment that substantially reduced postprandial hyperglycemia. A similar but less pronounced effect was seen on the age-related increase in basement membrane thickening in acarbose-treated non-diabetic control rats who demonstrated decreased glycated hemoglobin levels compared to non-treated control rats. Significant positive correlations between basement membrane thickness and glycated hemoglobin area suggest that diabetic retinal microangiopathy may be prevented by lowering the cumulative glucose exposure to the microvasculature, and that age-related basement membrane thickening is mediated by long-term exposure to normal glucose levels.
Department of Pathology, University of Manitoba, Winnipeg, Canada.
S
S
Chakrabarti
P V
PV
Cherian
A A
AA
Sima
D020909:Acarbose; D000375:Aging / Q000502:physiology*; D000818:Animals; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D001786:Blood Glucose / Q000032:analysis; D002196:Capillaries / Q000187:drug effects / Q000254:growth & development* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006029:Glycosuria; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011913:Rats, Inbred BB; D012171:Retinal Vessels / Q000187:drug effects / Q000254:growth & development* / Q000473:pathology; D014312:Trisaccharides / Q000494:pharmacology*
D020909:Acarbose; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D014312:Trisaccharides