Nocturnal pituitary hormone and renin profiles during chronic heat exposure.
To establish the principal endocrine systems involved in the initial adaptation to chronic passive heat exposure, responses of the hydromineral and pituitary systems were compared. Nocturnal plasma profiles of growth hormone, prolactin, thyrotropin, and plasma renin activity were determined during a period of prolonged heat exposure designed to simulate a hot climate. Two groups of six male subjects (G1 and G2) were kept for 11 days in a climatically controlled apartment. The G1 group was exposed to 20 degrees C throughout the study, and the G2 group was exposed to 20 degrees C for 5 days and to 35 degrees C for the following 6 days. Blood was collected continuously during the 1st and 10th nights from 2300 to 0700 h and was sampled in 10-min aliquots for hormone analysis. Heat exposure increased the nocturnal mean core temperature (P < 0.02) and stimulated plasma renin activity (P < 0.01) but had little effect on the pituitary hormones except for a small increase in prolactin (P < 0.05). For the G1 group there was no change in hormone profiles. These results demonstrate that the principal initial endocrine system involved in acclimatization to passive heat exposure is the renin-angiotensin system, reflecting counteractive measures against salt and water losses. In contrast, 5 days of continuous heat exposure does not provoke metabolic changes, indicated by the small effect on pituitary hormone profiles.
Laboratoire de Physiologie et de Psychologie Environnementale, Centre National de la Recherche Scientifique/Institut National de Recherche et de Sécurité, Strasbourg, France.
J
J
Saini
G
G
Brandenberger
J P
JP
Libert
M
M
Follenius
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D001831:Body Temperature / Q000502:physiology; D013006:Growth Hormone / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D008297:Male; D010907:Pituitary Hormones / Q000097:blood*; D010953:Plasma Volume / Q000502:physiology; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*; D012894:Sleep Stages / Q000502:physiology; D013546:Sweating / Q000502:physiology; D013972:Thyrotropin / Q000097:blood
D006454:Hemoglobins; D010907:Pituitary Hormones; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D012083:Renin