[Pharmacokinetics in arterial infusion chemotherapy].
The pharmacokinetics of arterial infusion chemotherapy was introduced. The pharmacokinetic rationales were based on the theories of "first pass effect" and "increased local concentration without first pass effect" advocated by Dr. Collins. These theories can offer much information to select the drug and to determine the administration schedule. However, for most of the drugs, the clinical pharmacokinetic studies are poor, and the optimal dose in bolus intraarterial infusion and the administration schedule is uncertain in terms of the dosage and hours. There are also some differences between pharmacokinetic understanding and clinical effect. Thus, further pharmacokinetic investigations and clinical studies are required to establish effective regimens for arterial infusion chemotherapy.
Dept. of Diagnostic Radiology, Aichi Cancer Center, Nagoya, Japan.
Y
Y
Arai
C
C
Kido
Y
Y
Ariyoshi
D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D005472:Fluorouracil