Nucleotide sequence of the Chinese hamster Na+/H+ exchanger NHE1.
We have cloned and sequenced the cDNA coding for the Chinese hamster Na+/H+ antiporter expressed in the CCL39 fibroblast cell line. This cDNA contains an open reading frame encoding a protein of 822 amino acids which is homologous to the human NHE1 isoform. Sequence comparison studies show that the first cytoplasmic loop of the transporter is completely different between the two species indicating that the conservation of this domain is not required for the function of the antiporter.
Centre de Biochimie-CNRS, Université de Nice-Sophia Antipolis, France.
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L
Counillon
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J
Pouysségur
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002460:Cell Line; D003001:Cloning, Molecular; D006224:Cricetinae; D003412:Cricetulus / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012689:Sequence Homology, Nucleic Acid; D017923:Sodium-Hydrogen Exchangers
D002352:Carrier Proteins; D017923:Sodium-Hydrogen Exchangers