Incorporating lactate/lipid discrimination into a spectroscopic imaging sequence.
A spectroscopic imaging sequence incorporating a two-shot lactate editing method was used in two human brain studies to image lactate and NAA. The subtractive editing method allows separate images of lactate, NAA, and lipids to be collected during a single study with no SNR penalty. The sequence uses a spectral-spatial excitation for slice selection and water suppression, and employs inversion recovery and an echo time of 136 ms for additional lipid suppression.
Magnetic Resonance Systems Research Laboratory, Stanford University, CA 94305-4055.
E
E
Adalsteinsson
D M
DM
Spielman
G A
GA
Wright
J M
JM
Pauly
C H
CH
Meyer
A
A
Macovski
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000737:chemistry; D002561:Cerebrovascular Disorders / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000032:analysis*; D008055:Lipids / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009837:Oligodendroglioma / Q000737:chemistry; D010296:Parietal Lobe / Q000737:chemistry
D007773:Lactates; D008055:Lipids; D001224:Aspartic Acid; C000179:N-acetylaspartate