Complete nucleotide sequence of the cDNA encoding rabbit coagulation factor VII.
Rabbit coagulation factor VII cDNA has been cloned and sequenced. Two rabbit liver cDNA libraries in lambda gt11 were screened using both random-primed, 32p-labelled, factor VII cDNAs and polymerase chain reaction technology. Three overlapping cDNA clones were isolated comprising a sequence of 1572 base pairs of DNA encoding an open-reading-frame of 443 amino acids. Mature circulating rabbit factor VII is predicted to contain 404 amino acids, two less than its human counterpart and three less than bovine factor VII.
Brothers
A B
AB
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Clarke
B J
BJ
Sheffield
W P
WP
Blajchman
M A
MA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D005167:Factor VII / Q000235:genetics*; D008969:Molecular Sequence Data; D011817:Rabbits
D004279:DNA, Viral; D005167:Factor VII; D004247:DNA; D004262:DNA Restriction Enzymes