Ocular complications of the acquired immunodeficiency syndrome. Focus on the treatment of cytomegalovirus retinitis with ganciclovir and foscarnet.
The most common ocular complication in patients with the acquired immunodeficiency syndrome (AIDS) is cytomegalovirus retinitis. Incidence figures vary from 20 to 76%. Patients with cytomegalovirus may suffer from mild visual impairment of one or both eyes, but as the disease progresses the retinitis will almost certainly lead to blindness. Although cytomegalovirus retinitis is not a life-threatening infection, it can largely diminish the patient's quality of life. Clinical trials for the treatment of cytomegalovirus retinitis with a number of antiviral drugs have resulted in two drugs of choice, ganciclovir and foscarnet. Both drugs have an initial efficacy with induction therapy of 80-90%, but maintenance therapy is always needed to prevent a relapse. To exclude systemic side-effects of ganciclovir, intravitreal administration has been investigated with good results. Combination therapy of foscarnet and ganciclovir may be worthwhile in resistant cytomegalovirus retinitis.
Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands.
W J
WJ
Keijer
D M
DM
Burger
G H
GH
Neuteboom
J L
JL
Vrooland
P L
PL
Meenhorst
C H
CH
Koks
J H
JH
Beijnen
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy; D005128:Eye Diseases / Q000150:complications* / Q000188:drug therapy; D017245:Foscarnet / Q000627:therapeutic use*; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D012173:Retinitis / Q000150:complications / Q000188:drug therapy
D017245:Foscarnet; D015774:Ganciclovir