Nonoxynol-9 protects mice against vaginal transmission of genital herpes infections.
A vaginal application of a commercially available contraceptive jelly containing nonoxynol-9 (N9) prevented vaginal transmission of herpes simplex virus type 2 (HSV-2) infections in the mouse. When N9 jelly was delivered to the vagina with the virus inoculum, 20 s before inoculum, or 5 min before inoculum, mice were completely protected from visible infection (P < .001). Protection lasted for at least 30 min (P < .03), and significant protection occurred even when the N9 jelly was delivered 15 min after the HSV-2 inoculum (P < .05). These results are consistent with results of studies using N9 products in other animal models and suggest that N9-based contraceptive products can provide significant protection against vaginal transmission of enveloped virus infections in animals.
Whaley
K J
KJ
Dept. of Biophysics, Johns Hopkins University, Baltimore MD 21218.
Barratt
R A
RA
Zeitlin
L
L
Hoen
T E
TE
Cone
R A
RA
D000818:Animals; D005260:Female; D006558:Herpes Genitalis / Q000517:prevention & control* / Q000635:transmission*; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D017137:Nonoxynol / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D012749:Sexually Transmitted Diseases / Q000517:prevention & control* / Q000635:transmission*; D018139:Simplexvirus / Q000302:isolation & purification; D014621:Vagina / Q000382:microbiology*
D017137:Nonoxynol; D017258:Medroxyprogesterone Acetate