Reversal of the effect of 17-beta-estradiol 17-beta-acetate on aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities in the uterus and liver of ovariectomized Bom:NMRI mice by 2-deoxyadenosine 3-phosphate.
When an adenylyl cyclase inhibitor, 2-deoxyadenosine 3'-phosphate, was administered together with 17-beta-estradiol 17-beta-acetate on ovariectomized Bom:NMRI mice, the short term effects of the hormone on the uterus aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities were reversed, whereas the effect on the liver enzymes was about the same for 17-beta-estradiol 17-beta-acetate and for 2-deoxyadenosine 3-phosphate.
Department of Biochemistry, University of Bergen, Norway.
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Berg
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D000818:Animals; D002850:Chromatography, Gel; D003838:Deoxyadenine Nucleotides / Q000494:pharmacology*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D010052:Ovariectomy; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology
D003838:Deoxyadenine Nucleotides; D004958:Estradiol; C072350:estradiol 17-acetate; C022354:phosphoaminoacyl-tRNA synthetase phosphatase; D010749:Phosphoprotein Phosphatases; D000604:Amino Acyl-tRNA Synthetases