Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell.
A cDNA clone encoding bone morphogenetic protein 4 (BMP 4) has been isolated from a primary fetal rat calvarial cell cDNA library. Sequencing of this clone has revealed a single open reading frame encoding a 408 amino acid protein. Comparison of 5' noncoding exon 1 portion of this cDNA with that of human bone and prostate BMP4 cDNA shows that BMP4 gene expression may possess tissue specificity.
Chen
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D
University of Texas Health Science Center at San Antonio 78284-7877.
Feng
J Q
JQ
Feng
M
M
Harris
M A
MA
Mundy
G R
GR
Harris
S E
SE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins; D001859:Bone Neoplasms / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002460:Cell Line; D003001:Cloning, Molecular; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats
D019485:Bone Morphogenetic Proteins; D011506:Proteins; D012333:RNA, Messenger