Study of left and right ventricular function in Romano-Ward syndrome.
OBJECTIVE
To examine left and right ventricular contraction in Romano-Ward syndrome: does abnormal myocardium affect the predisposition to arrhythmia?


METHODS
Tomographic radionuclide ventriculography was performed after the red blood cells were labelled conventionally with stannous pyrophosphate and technetium-99m.


METHODS
Department of Nuclear Medicine, Aberdeen Royal Infirmary.


METHODS
Eight subjects from two families known to have Romano-Ward syndrome, four of whom (two from each family) had had symptoms.


RESULTS
The five subjects from family 1 had normal left ventricular contraction; two had subtle abnormalities of right ventricular phase. in family 2 all three subjects had abnormal left ventricular contraction (reduced amplitude in three, abnormal phase in two). All had subtle abnormalities of right ventricular phase.


CONCLUSIONS
Abnormal right or left ventricular myocardium may be partly or wholly responsible for the repolarisation changes seen on the electrocardiogram of these families or may act as an ectopic focus to start ventricular tachycardias in a susceptible heart.
Department of Cardiology, Aberdeen Royal Infirmary, Foresterhill.
S J
SJ
Cross
J C
JC
Dean
H S
HS
Lee
M Y
MY
Norton
N T
NT
Evans
F
F
Smith
K
K
Jennings
S
S
Walton
D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*