Rheumatoid arthritis: new science, new treatment.
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that occurs two to four times as often in women as in men and increases in incidence with advancing age. It affects synovial-lined joints and can also affect the pulmonary, cardiac, nervous, integumentary, and reticuloendothelial systems. RA is manifested clinically by malaise and fatigue, followed by a symmetric pattern of joint inflammation characterized by pain and stiffness. RA most likely occurs in the setting of a genetically predisposed individual, triggered by infectious agents or endogenous antigens. Many of the newer treatments being studied involve blocking cytokine-mediated interactions between cells of the synovium.
Kaiser-Permanente Medical Center, South Sacramento, CA.
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D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003510:Cyclohexanes; D004167:Diphtheria Toxin / Q000627:therapeutic use; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D053590:Interleukin 1 Receptor Antagonist Protein; D007376:Interleukin-2 / Q000627:therapeutic use; D008213:Lymphocyte Activation; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008911:Minocycline / Q000627:therapeutic use; D009363:Neoplasm Proteins / Q000627:therapeutic use; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D010321:Parvoviridae / Q000302:isolation & purification; D047889:Receptors, Tumor Necrosis Factor, Type II; D011993:Recombinant Fusion Proteins; D012717:Sesquiterpenes / Q000627:therapeutic use; D012795:Sialoglycoproteins / Q000627:therapeutic use; D013585:Synovitis / Q000473:pathology; D053319:Tumor Necrosis Factor Decoy Receptors
D000911:Antibodies, Monoclonal; D003510:Cyclohexanes; C054780:DAB(486)-interleukin 2; D004167:Diphtheria Toxin; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007376:Interleukin-2; D009363:Neoplasm Proteins; D047889:Receptors, Tumor Necrosis Factor, Type II; D011993:Recombinant Fusion Proteins; D012717:Sesquiterpenes; D012795:Sialoglycoproteins; D053319:Tumor Necrosis Factor Decoy Receptors; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D008911:Minocycline; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D008727:Methotrexate