Antigen-selected T-cell receptor diversity and self-nonself homology.
Recent studies indicate that the T-cell receptor (TCR) repertoire selected by certain antigenic peptide-MHC combinations can be extremely diverse. This is in contrast to earlier studies reporting T-cell responses which were limited in terms of TCR diversity. In this viewpoint, we suggest these variations in TCR diversity may be explained by taking into account the homology between some antigens and self proteins to which T cells are tolerant.
Casanova
J L
JL
INSERM 132, Hôpital Necker-Enfants Malades, Paris, France.
Maryanski
J L
JL
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007108:Immune Tolerance; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta