[The efficacy of semiselective intraarterial infusion therapy in advanced or recurrent gastric cancer].
We use CDDP and have compared the semiselective intraarterial infusion (ia group) with intravenous infusion (i.v. group) by measuring levels of the administered drug in blood and the abdominal organ tissues. In portal blood, the ia group showed a significant increase compared with the i.v. group. The patient tissue level was compared between the two groups. Higher levels were obtained in the peritoneum in the ia group. These results suggest that semiselective intraarterial infusion therapy is effective in peritoneal dissemination.
Dept. of Surgery, Saiseikai Yokohama City Nanbu Hospital.
K
K
Okada
T
T
Suda
F
F
Kito
T
T
Imada
Y
Y
Yamamoto
H
H
Takemura
T
T
Okukawa
Y
Y
Rino
O
O
Kobayashi
M
M
Sairenji
D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008198:Lymph Nodes / Q000378:metabolism; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D002945:Cisplatin