Psychoactive drugs in children.
Monitoring anticonvulsant drugs may be unnecessary for many patients except those in high-risk groups such as those with metabolic disorders, neurodegenerative diseases, and history of past drug reactions. Several studies reviewed kinetic differences between children and adults. Plasma carnitine is often reduced by administration of anticonvulsants, although the clinical significance of this is uncertain. Midazolam and analgesics such as fentanyl have become popular for sedation for pediatric procedures. Several studies reviewed safety and kinetics of this method of sedation. The midazolam decreases memory for the procedure and reduces anticipatory anxiety. Several studies also reviewed use of methylphenidate for hyperactivity and risks of tricyclic antidepressants in children.
Johns Hopkins University School of Medicine, Baltimore, Maryland.
M V
MV
Johnston
D000614:Aminocaproates / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008874:Midazolam / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D020888:Vigabatrin
D000614:Aminocaproates; D000927:Anticonvulsants; D011619:Psychotropic Drugs; D020888:Vigabatrin; D008874:Midazolam