Muscle hypertrophy with large-scale weight loss and resistance training.
The combined effects of exercise and energy restriction on changes in body fat and fat-free mass (FFM) are controversial. This study was conducted to determine whether muscle hypertrophy is possible during weight loss. Fourteen obese females received a 3360-kJ/d liquid diet for 90 d. Seven subjects received a weight training (WT) regimen and seven subjects remained sedentary (C). Biopsy samples were obtained from the vastus lateralis muscle at baseline and after 90 d of treatment. The average weight loss over the 90-d period was 16 kg with approximately 24% of the weight loss from FFM and 76% from fat. The amount and composition of the weight loss did not differ between WT and C groups. The cross-sectional area of slow twitch and fast twitch fibers was unchanged by treatment in C subjects but significantly increased in WT subjects. It appears that weight training can produce hypertrophy in skeletal muscle during severe energy restriction and large-scale weight loss.
Donnelly
J E
JE
Human Performance Laboratory, University of Nebraska at Kearney 68849.
Sharp
T
T
Houmard
J
J
Carlson
M G
MG
Hill
J O
JO
Whatley
J E
JE
Israel
R G
RG
D000328:Adult; D001823:Body Composition; D001835:Body Weight; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D006984:Hypertrophy; D009132:Muscles / Q000473:pathology*; D009765:Obesity / Q000628:therapy; D014891:Weight Lifting; D015431:Weight Loss