Anti-viral activity of sulfated chitin derivatives against Friend murine leukaemia and herpes simplex type-1 viruses.
Sulfated chitin derivatives, selected for their low toxicity and high inhibitory activity of melanoma metastasis, were examined for anti-viral activity against Friend murine leukaemia, herpes simplex type-1 (HSV) and Sendai viruses. Carboxymethyl chitin with a 7.66% degree of sulfation (SCM-chitin III) showed a significant inhibition of Friend murine leukaemia helper virus (F-MuLV) and HSV, but not of Sendai virus growth in vitro. Sulfated N-deacetylated chitin had a significant but weak activity against F-MuLV and HSV infections. Carboxymethyl chitin showed no effect on these infections in vitro. SCM-chitin III also exhibited anti-viral activity in vivo by suppressing the splenomegaly which was caused by prior infection of mice with FV, a complex of F-MuLV and spleen focus-forming virus.
School of Veterinary Medicine, Rakuno-gakuen University, Ebetsu, Japan.
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C
Ishihara
K
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Yoshimatsu
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M
Tsuji
J
J
Arikawa
I
I
Saiki
S
S
Tokura
I
I
Azuma
D000818:Animals; D002478:Cells, Cultured; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D048271:Chitosan; D005455:Fluorescent Antibody Technique; D005622:Friend murine leukemia virus / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects / Q000254:growth & development; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D013431:Sulfates; D014709:Vero Cells
D013431:Sulfates; D002686:Chitin; C044872:O-(carboxymethyl)chitin; D048271:Chitosan