Characteristics of protooncogene expression in A5 cells.
Stimulation of beta-adrenergic receptors by isoproterenol or addition of 8-BrcAMP rapidly and transiently induces the expression of the protooncogenes, c-fos, and jun B, but not that of c-jun in A5 cells. These results indicate that different intracellular pathways may operate within the same cell for the induction of this group of early response genes. The inducibility of c-fos and jun B genes by either isoproterenol of 8-BrcAMP is transcriptionally regulated and accompanied by increases in their respective products. Furthermore, both c-fos and jun B mRNA levels are elevated at G0/G1 phase of the A5 cell cycle and are inducible by isoproterenol or 8-BrcAMP at the different phases of the cell cycle. These data further suggest a possible role of c-fos and jun B in A5 cell cycle.
Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
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D000818:Animals; D002453:Cell Cycle; D002460:Cell Line; D004848:Epithelium / Q000502:physiology; D005786:Gene Expression Regulation; D016762:Genes, fos / Q000235:genetics*; D016758:Genes, jun / Q000235:genetics*; D051381:Rats; D013363:Submandibular Gland / Q000502:physiology*