[A new intraarterial high-dose chemotherapy for pelvic tumor using direct hemoperfusion under infrahepatic inferior vena caval isolation].
We have developed a new system consisting of direct hemoperfusion (DHP) under the infrahepatic vena caval isolation for high-dose intraarterial chemotherapy of pelvic tumor. In a patient with unresectable retroperitoneal liposarcoma, a catheter (16 F) was introduced into the left common iliac vein via the left greater saphenous vein. In addition, a balloon catheter (16F) was introduced into the intrahepatic inferior vena cava through the right greater saphenous vein. Adriamycin (100 mg/body) was administered through the internal iliac artery for 15 min. During drug infusion, the infrahepatic vena caval blood was isolated by balloon occlusion, and filtered by DHP cartridges. Then, the blood was re-directed to the patient through the central lumen of the balloon catheter. The patient showed good hemodynamic tolerance during this treatment. Adriamycin toxicities including leucopenia, gastrointestinal problems and alopecia were not observed throughout the follow-up period. Based on these results, it was concluded that this method allows high-dose intraarterial chemotherapy of the kidney and pelvis without increased systemic toxicities.
First Dept. of Surgery, Kobe University School of Medicine.
T
T
Fukumoto
Y
Y
Ku
Y
Y
Saitoh
D000368:Aged; D002404:Catheterization; D004317:Doxorubicin / Q000008:administration & dosage* / Q000097:blood; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008080:Liposarcoma / Q000097:blood / Q000473:pathology / Q000628:therapy*; D008297:Male; D009361:Neoplasm Invasiveness; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy*; D014682:Vena Cava, Inferior
D004317:Doxorubicin