Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites.
The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implant-related osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combination with antibiotic-impregnated acrylic bone cement, all failed to eradicate the infections.
Korkusuz
F
F
Osaka University Medical School, Japan.
Uchida
A
A
Shinto
Y
Y
Araki
N
N
Inoue
K
K
Ono
K
K
D000818:Animals; D002516:Ceramics; D004337:Drug Carriers; D017886:Durapatite; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006882:Hydroxyapatites / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008855:Microscopy, Electron, Scanning; D010019:Osteomyelitis / Q000188:drug therapy*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000648:ultrastructure
D004337:Drug Carriers; D005839:Gentamicins; D006882:Hydroxyapatites; D017886:Durapatite