The mushroom Pleurotus ostreatus reduces secretion and accelerates the fractional turnover rate of very-low-density lipoproteins in the rat.
In male rats fed a diet containing 1.5% cholesterol and 5% of dried mushroom (Pleurotus ostreatus) a significantly reduced accumulation of cholesterol in serum (by 45%) and the liver (by 15%) was observed at the end of the 12th week of the experiment. The decrease in serum cholesterol level by more than 90% is a consequence of the decreased cholesterol concentration of very-low-density lipoproteins (VLDL) and of low-density lipoproteins. Consumption of P. ostreatus reduces the total VLDL entry into the circulation by 19% and accelerates (by 49%) fractional turnover rate of VLDL.
Research Institute of Nutrition, Faculty of Chemical Technology, Bratislava, Slovakia.
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Bobek
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Kuniak
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Ozdín
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood / Q000378:metabolism; D004032:Diet; D008079:Lipoproteins, VLDL / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D011124:Polyporaceae; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol