Evidence that endogenous arginine-vasopressin (AVP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
A 7-day subcutaneous infusion with the AVP antagonist [Deamino-Pen1, Val4, D-Arg8]-vasopressin (AVP-A; 3 nmol.kg-1 x min-1) significantly lowered plasma aldosterone concentration in rats, without affecting the plasma levels of ACTH and corticosterone. Prolonged AVP-A treatment caused a marked atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells, without inducing any significant change in zona fasciculata morphology. Isolated ZG cells from AVP-A-infused rats evidenced a notable decrease in both their basal and maximally-stimulated aldosterone production. The simultaneous infusion of rats with AVP (3 nmol.kg-1 x min-1) completely reversed all these effects of AVP-A. These findings suggest that endogenous AVP may be specifically involved in the maintenance of the growth and steroidogenic capacity of rat adrenal ZG. Moreover, they seem to indicate that under basal conditions the pituitary-adrenal-glucocorticoid axis is independent of AVP release.
Department of Anatomy, University of Padua, Italy.
G
G
Mazzocchi
A
A
Markowska
L K
LK
Malendowicz
F
F
Musajo
V
V
Meneghelli
G G
GG
Nussdorfer
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000096:biosynthesis* / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000502:physiology*; D002452:Cell Count / Q000187:drug effects; D002469:Cell Separation; D048429:Cell Size / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015384:Zona Glomerulosa / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*
D000804:Angiotensin II; D001127:Arginine Vasopressin; D000450:Aldosterone; C007223:vasopressin, 1-deamino-4-Val-8-Arg-; D000324:Adrenocorticotropic Hormone; D003894:Deamino Arginine Vasopressin; D011188:Potassium