[The reciprocal relationships between the epiphysis and the suprachiasmatic nuclei of the hypothalamus during the restructuring of the circadian mobility in rats under an altered light regimen].
Pinealectomy and reserpine advanced the reorganization of the circadian rhythm of motor activity of rats following a ten-hour shift in the photoperiod. Bilateral electrolytic lesion of the hypothalamic suprachiasmatic nuclei and administration of the antidepressant drug, imipramine, on the contrary, delayed the rhythm change. The results suggest a possible antagonistic reciprocal relationship between the pineal gland and the main pacemaker, whose balance causes a gradual adaptation of animals to the changing environment. Fast reorganization of motor activity at pineal dysfunction or under the influence of depressogenic drugs could cause desynchronization and psychiatric disorders in a form of depression.
Arushanian
E B
EB
Baturin
V A
VA
Popov
A V
AV
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D007099:Imipramine / Q000494:pharmacology; D008027:Light; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D017440:Photoperiod; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013493:Suprachiasmatic Nucleus / Q000502:physiology* / Q000601:surgery; D013997:Time Factors
D012110:Reserpine; D007099:Imipramine