Estimation of vaccine efficacy from epidemics of acute infectious agents under vaccine-related heterogeneity.
A stochastic epidemic model is formulated for the study of the protective effects of vaccination in a population that is stratified by vaccine-related factors. The epidemic model is transformed into a counting process, and then martingale-based methods are used to provide estimators of vaccine efficacy and their variances. Following an example, various extensions of the model are discussed.
Longini
I M
IM
Division of Biostatistics, Emory University School of Public Health, Atlanta, Georgia.
Halloran
M E
ME
Haber
M
M
D000208:Acute Disease; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000453:epidemiology*; D006801:Humans; D007114:Immunization; D008433:Mathematics; D015233:Models, Statistical; D014612:Vaccines
D014612:Vaccines