11q- and constitutional X trisomy in a patient with M5b acute non-lymphocytic leukemia.
A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subsequently, two courses of chemotherapy for resistant ANLL were administered without achieving complete remission. Abnormalities of chromosome 11 are typical of M4 and M5 ANLL. X trisomy is one of the most common human aneuploidia; however, correlation with increased incidence of hematological neoplasia has not been described.
Bigazzi
C
C
Cattedra e Divisione di Ematologia, Siena, Italy.
Galieni
P
P
Scarinci
R
R
Vivarelli
R
R
Bucalossi
A
A
Biancolini
G
G
Falbo
R
R
Vessichelli
F
F
Dispensa
E
E
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014314:Trisomy; D014960:X Chromosome