Efficacy of once-daily lisinopril monotherapy in systemic hypertension.
Lisinopril is a new, long-acting angiotensin-converting enzyme inhibitor formulated for once-daily treatment of hypertension. This study assessed the 24-h efficacy and tolerability of lisinopril in Chinese patients with mild to moderate hypertension of World Health Organization Stages I to II. A total of 30 patients aged 30 to 60 years (mean 47 +/- 9) entered a 2-week washout period. All patients had ambulatory diastolic blood pressure (BP) > 90 mmHg and were given active treatment with lisinopril for 4 to 7 weeks. The dose of lisinopril was titrated from 10 to 40 mg daily (at 8-9 A.M.). In each patient, 24-h ambulatory blood pressure (BP) monitoring (SpaceLabs 90202) was performed twice, once before and once following treatment. Mean 24-hour systolic/diastolic BPs after lisinopril were significantly decreased compared with baseline values (132 +/- 12/86 +/- 7 vs. 150 +/- 11/98 +/- 7 mmHg; p < 0.0005/0.0005). The average dose of lisinopril was 14.5 +/- 5 mg daily after a titration period of 5 weeks of treatment. Mean daytime (6 A.M. to 6 P.M.) BP decreased from 152 +/- 11/100 +/- 8 to 134 +/- 12/87 +/- 8 mmHg (p < 0.0005/0.0005) and nighttime (6 P.M. to 6 A.M.) BP from 147 +/- 14/95 +/- 9 to 128 +/- 14/83 +/- 8 mmHg (p < 0.0005/0.0005). BP reduction was more pronounced during the night. Before treatment, the circadian variation showed a peak BP at 11 A.M. and nadir at 3 P.M. After treatment, significant BP reduction (p < 0.0005/0.0005) was seen throughout the 24-h period.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
Y S
YS
Hwang
H W
HW
Yen
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D002940:Circadian Rhythm / Q000187:drug effects; D004151:Dipeptides / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D017706:Lisinopril