Erythrocyte Na/K flux ratio in relation to sodium intake and a family history of essential hypertension in normotensive children.
Erythrocyte Na/K flux ratio was examined in relation to a family history of essential hypertension (FH-HT) and plasma and urine electrolytes in 84 normotensive children (13-15 yrs old), and in relation to sodium intake in six children with acute glomerulonephritis or IgA nephropathy who had normal renal function (6-13 yrs old). Erythrocyte Na/K flux ratio was significantly lower in children with a family history of essential hypertension than in those without. Plasma and urine electrolytes (Na and K) showed no significant differences between children with and without a family history of essential hypertension, although erythrocyte Na/K flux ratio was negatively correlated with serum K level in the whole group. Furthermore, erythrocyte Na/K flux ratio was unchanged before and after the restriction of sodium intake in children with nephropathy. These findings suggest that the erythrocyte Na/K flux ratio may be suppressed in normotensive children with a family history of essential hypertension as previously reported in hypertensive adults, and that plasma K level should be considered first when evaluating the erythrocyte Na/K flux ratio.
Department of Paediatrics, Niigata University School of Medicine, Japan.
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Uchiyama
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Satokata
D000208:Acute Disease; D000293:Adolescent; D004912:Erythrocytes / Q000378:metabolism*; D005921:Glomerulonephritis / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000378:metabolism / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D011188:Potassium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012964:Sodium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage; D000254:Sodium-Potassium-Exchanging ATPase
D012982:Sodium, Dietary; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium