Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice.
The effects of the excitatory amino acid (EAA) receptor antagonists MK-801 (non-competitive NMDA receptor antagonist), DNQX (competitive non-NMDA receptor antagonist) and 5,7-DCKA (antagonist of glycine site of NMDA receptor) have been examined on the naloxone (4 mg/kg, i.p.)-precipitated withdrawal jumping behaviour in morphine-dependent mice. The results indicate that withdrawal jumping behaviour in morphine-dependent mice was attenuated by all three EAA receptor antagonists, MK-801, DNQX and 5,7-DCKA. However, MK-801, DNQX and 5,7-DCKA inhibited the jumping behaviour in a relatively narrow dose range.
Department of Pharmacology, Faculty of Medical and Health Sciences, Erasmus University, Rotterdam, The Netherlands.
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000627:therapeutic use; D005998:Glycine / Q000378:metabolism; D007736:Kynurenic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009021:Morphine Dependence / Q000523:psychology*; D009270:Naloxone / Q000494:pharmacology*; D011810:Quinoxalines / Q000627:therapeutic use; D017459:Receptors, Amino Acid / Q000037:antagonists & inhibitors*; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000523:psychology
D011810:Quinoxalines; D017459:Receptors, Amino Acid; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D009270:Naloxone; C056723:FG 9041; D016291:Dizocilpine Maleate; D007736:Kynurenic Acid; C066192:5,7-dichlorokynurenic acid; D005998:Glycine