Characterization of antacid compounds containing both aluminum and magnesium. I. Crystalline powders.
The composition and antacid properties of 10 samples of crystalline antacids containing both aluminum and magnesium were determined. The composition was found to vary significantly, even within the same type of antacid. For example, three of four hydrotalcite samples exhibit evidence of the presence of a minor phase of amorphous aluminum hydroxide. Almagate and almagcit, which are claimed to be unique compounds, were found to be composed of hydrotalcite, magnesium hydroxycarbonate, and/or magnesium carbonate and amorphous aluminum hydroxide. All three magaldrate samples examined contained a minor phase of amorphous aluminum hydroxide. All 10 samples passed the preliminary antacid test and had high acid neutralizing capacities. However, the rate of acid neutralization varied between samples. In some cases the rate of acid neutralization at a dose of 400 mg was too slow to raise the pH to 3.0 as required by the Rossett-Rice test.
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907.
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Peterson
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Perry
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Masood
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Lin
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White
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Fritsch
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Haeusler
D000535:Aluminum / Q000737:chemistry*; D000536:Aluminum Hydroxide / Q000737:chemistry; D000863:Antacids / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry; D003460:Crystallization; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000737:chemistry*; D008276:Magnesium Hydroxide / Q000737:chemistry; D011208:Powders; D014961:X-Ray Diffraction
D000863:Antacids; D002254:Carbonates; D011208:Powders; C083305:almagcit; C083304:magnesium hydroxycarbonate; C010467:hydrotalcite; C043698:almagate; D000536:Aluminum Hydroxide; C016545:magaldrate; D000535:Aluminum; D008274:Magnesium; D008276:Magnesium Hydroxide