[Experimental autoimmune uveitis and retinitis induced by S-antigen immunization].
Experimental autoimmune uveoretinitis (EAU) was induced in Lewis rats by a single injection in foot pads of S-antigen in complete Freund's adjuvant. Clinically, during the 2 nd week after immunization, EAU starts by acute anterior, lately--posterior uveitis. Peptide S2, located in the N-terminal region of S-antigen, has a regulatory effect on EAU, while peptide M is a pathogenic site inducing EAU. Antibodies directed at peptide S2 were observed in rats not developing EAU while high levels of antibodies directed at S-antigen and peptide M were present in all rats.
Laboratorium Immunopatologii Oka, INSERM U 86, Paryzu.
M
M
Misiuk-Hojło
J
J
Ruiz-Moreno
B
B
Thillaye
Y
Y
de Kozak
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D019393:Arrestin; D001324:Autoantigens / Q000008:administration & dosage*; D001327:Autoimmune Diseases / Q000276:immunology*; D005136:Eye Proteins / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D012173:Retinitis / Q000276:immunology*; D014605:Uveitis / Q000276:immunology*
D000941:Antigens; D019393:Arrestin; D001324:Autoantigens; D005136:Eye Proteins