Papillomavirus infection and its pathologic correlate in sexually active adolescents.
We investigated the prevalence of human papillomavirus (HPV) and its pathologic correlation in an adolescent clinic population (13-20 years, mean 16 years) over a 2-year period. 413 cervical specimens were obtained and analyzed cytologically and by a Southern Blot (SB) method for HPV DNA. 277 specimens from 210 patients could be fully analyzed. 23 patients (10.9%) were positive for HPV DNA by SB. Cytologic findings in these 23 patients demonstrated changes compatible with low-grade squamous intraepithelial lesions (LGSIL) and HPV-associated changes in 4 cases (17%). Cervical biopsies obtained in 3 cases with abnormal cytology demonstrated LGSIL in all cases. 6 patients were retested for HPV 2 to 6 months after the initial positive, two showed persistence of the initial virus, one was positive for a different HPV type and three were negative for HPV DNA.
Children's Hospital Medical Center, Akron, Ohio 44308.
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I
Hosny
R
R
Novak
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D
Zabel
S
S
Dasu
J
J
Fitzgibbon
D
D
Agamanolis
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000302:isolation & purification*; D012725:Sexual Behavior / Q000706:statistics & numerical data; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D002577:Uterine Cervical Diseases / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology