Effect of anticardiolipin antibody in patients with recurrent fetal loss on thrombomodulin-dependent protein C activation.
In order to approach an understanding of the mechanisms of fetal death in patients with antiphospholipid syndrome we investigated the association between protein C activity and anticardiolipin antibody. Protein C activity in vivo was decreased in some patients with recurrent fetal loss and a high ACA titer. This study suggests that anticardiolipin antibody in patients with recurrent fetal loss may inhibit activation of protein C by thrombomodulin.
Toyoshima
K
K
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Japan.
Makino
T
T
Ozawa
N
N
Umeuchi
M
M
Nozawa
S
S
D000026:Abortion, Habitual / Q000097:blood* / Q000276:immunology*; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D066298:In Vitro Techniques; D011247:Pregnancy; D011486:Protein C / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D018179:Receptors, Thrombin
D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G; D011486:Protein C; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin