[Structure and function of cardiac sarcoplasmic reticulum Ca(2+)-ATPase].
The sarcoplasmic reticulum (SR) calcium pump plays a major role in the beat-to-beat removal of cytoplasmic Ca2+ in mammalian cardiac myocytes. The cardiac SR Ca(2+)-ATPase is one of the isoforms of the endoplasmic reticulum (ER) Ca(2+)-ATPases that are encoded by a gene family, consisting of at least three separate genes (SERCA1, SERCA2 and SERCA3). The high similarity in primary structure of these isoforms suggests that the basic structure-function relationship in these isoforms is also similar, although some differences have been noted between the functions of these isoforms. These isoforms are expressed in a tissue selective manner and change their expression during ontogeny or in response to physiological and pathological stimuli. In this article, we review the recent advances in the study of the cardiac SR Ca(2+)-ATPase in terms of its structure and function, and its expression.
M
M
Shigekawa
T
T
Iwamoto
T
T
Ikeda
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D009206:Myocardium / Q000201:enzymology*; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*
D000252:Calcium-Transporting ATPases