Effects of dopamine on type I chemoreceptor cells of the rat carotid body.
The effects of dopamine (DA) were studied on type I cells of the rat carotid body. DA (0.35 to 8.4 x 10(-4) M) elicited a long-lasting depolarization and decreased input resistance (Ro) in 75% of the cells, in a dose-dependent manner. Hyperpolarization and increased Ro were observed in 8% of cells. Membrane potential (Em) and Ro changes were highly correlated (-0.62, P < 0.001). The reversal potential (Erev) of the DA effect was +2.16 +/- 4.75 (mV +/- S.E.M.).
Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
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L
Monti-Bloch
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V
Abudara
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P
Aguilera
D000818:Animals; D002344:Carotid Body / Q000187:drug effects*; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D004298:Dopamine