The role of Epstein-Barr virus subtypes in human immunodeficiency virus-associated lymphoma.
High grade B cell non-Hodgkin's lymphoma (NHL) is an increasingly important problem in individuals infected with the human immunodeficiency virus (HIV). Fifty percent of these tumours harbour the Epstein-Barr virus (EBV) and there is an equal frequency of EBV A and B-subtypes in the tumours. This contrasts with the recent report that only A-type EBV is associated with Hodgkin's disease. Such studies are challenging the traditional models of EBV-associated lymphomagenesis and showing the way for further studies in this field. This article reviews the studies of EBV subtypes in HIV-associated NHL and uses this new knowledge to discuss the role of EBV in lymphomagenesis.
Boyle
M J
MJ
Centre for Immunology, St. Vincent's Hospital, Sydney, Australia.
Sculley
T B
TB
Penny
R
R
Sewell
W A
WA
Tschuchnigg
M
M
Berger
M F
MF
Cooper
D A
DA
D000956:Antigens, Viral / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000382:microbiology*
D000956:Antigens, Viral; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens