Urinary testosterone as a marker of risk of recurrence in operable breast cancer.
We investigated the role of urinary testosterone levels as a marker of risk of recurrent disease in 113 operable breast cancer patients (70 premenopausal, 43 postmenopausal). Twenty-four-hour urine collections for testosterone measurement were obtained before surgical treatment, between 20-40 days thereafter, and then every 6 months for 5 years. The cutoff values to separate 'high testosterone (A+)' from 'normal testosterone (A-)' were 8.0 micrograms/24 h in premenopause and 4.9 micrograms/24 h in postmenopause. Urinary testosterone levels were considered high when they exceeded the cutoff value in at least 2 of the first 3 measurements (pretreatment, post-treatment, 6 months) of each patient. According to the aforementioned criterion, 33 patients (29.2%) had high testosterone levels, which were associated to axillary node involvement in 16 patients. Thirteen of the latter relapsed during the 5-year follow-up period (5/7 in premenopause, 8/9 in postmenopause). Relapse-free survival (RFS) curves were drawn only for node-positive patients owning to the small number of recurrences observed in the node-negative group. In premenopausal node-positive patients, RFS was significantly different for patients presenting high and normal urinary testosterone levels (77% vs 28%, respectively; logrank test, p < 0.006). In postmenopausal node-positive patients, RFS was also different between the two groups (54% vs 11% in 'high' and 'normal' excretors, respectively) but the difference was not statistically significant. The present findings suggest that urinary testosterone is a prognostic indicator of early breast cancer recurrence in node-positive patients.
National Cancer Institute of Milan, Italy.
P
P
Ballerini
S
S
Oriana
P
P
Duca
A
A
Martinetti
E
E
Venturelli
L
L
Ferrari
S
S
Dolci
G
G
Secreto
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000652:urine*; D001943:Breast Neoplasms / Q000601:surgery / Q000652:urine*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000652:urine*; D017698:Postmenopause; D011237:Predictive Value of Tests; D017697:Premenopause; D012307:Risk Factors; D013739:Testosterone / Q000652:urine*
D014408:Biomarkers, Tumor; D013739:Testosterone