Toxicological investigations on silicon carbide. 1. Inhalation studies.
The question of lung damage as a result of exposure to silicon carbide (SiC) was investigated by inhalation experiments to obtain information on the qualitative response of lung tissue to the test substance (SiC). For comparison, quartz, kaolinite, and tempered clay dusts were used. The indices for the effects of the dusts studied were organ weights, numbers of bronchoalveolar cells, lung surfactant phospholipid concentrations including subfractions, and lung clearance. Exposure to the test samples was carried out according to the Essen inhalation model in two independent series. The results of the two series were similar: Compared with sham controls, exposure to SiC did not affect the indices studied. Even at a low dose (a quarter of the SiC dose) quartz gave pronounced deviations in all indices. In particular, an increase in granulocytes indicated toxic properties of the dust. The long term elimination of quartz from the lung was worse than that of SiC. The kaolinite and tempered clay dusts were intermediate between SiC and quartz based on several of the indices studied. It is concluded that SiC is deposited practically inert in the lung.
Bruch
J
J
Institute for Hygiene and Occupational Medicine, University of Essen, Medical School (Universitätsklinikum), Germany.
Rehn
B
B
Song
H
H
Gono
E
E
Malkusch
W
W
D000280:Administration, Inhalation; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002244:Carbon / Q000493:pharmacokinetics / Q000633:toxicity*; D017554:Carbon Compounds, Inorganic; D002452:Cell Count / Q000187:drug effects; D004391:Dust / Q000009:adverse effects*; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D008482:Mediastinum; D009929:Organ Size / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017655:Silicon Compounds / Q000493:pharmacokinetics / Q000633:toxicity*
D017554:Carbon Compounds, Inorganic; D004391:Dust; D011663:Pulmonary Surfactants; D017655:Silicon Compounds; D002244:Carbon; C022088:silicon carbide