[The role of cyclic AMP and cyclic GMP in realizing an inotropic effect of verapamil on the heart muscle].
The effect of verapamil on dynamics of cAMP and cGMP was studied during the single heart cycle using the isolated perfused guinea pig heart activated by isoproterenol. The changes of cyclic nucleotides were Ca(2+)-dependent; verapamil altered the cAMP and, to a lesser extent, the cGMP dynamics in the myocardium apparently by means of shifts in homeostasis of Ca2+ in cardiomyocytes. Importance of cyclic nucleotides and their interaction in realization of the inotropic effect of verapamil are discussed.
I B
IB
Bardamova
S A
SA
Afanas'ev
D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium