Foscarnet treatment in various cytomegalovirus infections.
We examined the effect of foscarnet (Foscavir) in 15 AIDS patients with cytomegalovirus infection. Cytomegalovirus infection was presented as retinits (n = 8), colitis (n = 3), oral (n = 1) and perianal ulcers (n = 3) and pneumonitis (n = 1). Induction therapy with foscarnet showed a complete response in 9 and a partial response in 6 patients after a medium therapy of 3.5 weeks. Three patients showed progressive disease under ganciclovir and were treated subsequently with foscarnet. Main side effects were ulcers of the glans penis (n = 6) and a rise of creatinine (> 1.5 mg/dl; n = 4). Therapy was changed to ganciclovir because of renal toxicity in 1 patient receiving induction therapy with foscarnet. Within a period of foscarnet therapy between 5 and 9 months (median: 7 months) no clinical progression occurred. Medium survival after diagnosis of cytomegalovirus infection was 7.4 months. We describe our experience with foscarnet and compare treatment results of cytomegalovirus infection at certain locations.
Brockmeyer
N H
NH
Department of Dermatology, University of Essen, Germany.
Hengge
U R
UR
Mertins
L
L
Malessa
R
R
Steinmetz
R
R
Gooss
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D003092:Colitis / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D015828:Eye Infections, Viral / Q000188:drug therapy; D005401:Fissure in Ano / Q000188:drug therapy; D017245:Foscarnet / Q000009:adverse effects / Q000627:therapeutic use*; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012173:Retinitis / Q000188:drug therapy; D013281:Stomatitis, Aphthous / Q000188:drug therapy
D017245:Foscarnet; D015774:Ganciclovir