[Sciatic nerve paralysis following intraarterial chemotherapy for bladder cancer: reports of two cases].
Bilateral sciatic nerve paralysis developed in two patients with invasive bladder cancer following intraarterial infusion of cisplatin (CDDP) and 4'-0-tetrahydropyranyladriamycin (THP) as preoperative adjuvant chemotherapy. Balloon catheters were selectively inserted into both internal iliac arteries, and CDDP 100 mg/m2 and THP 40 mg/m2 were administered under balloon occlusion. Pain of lower extremities developed soon after infusion and was gradually followed by paralysis. One patient recovered from paralysis partially after 4 months, but the other patient didn't recover. The use of balloon catheters resulted in an excessive concentration of chemotherapeutic agents with the adverse action on the sciatic nerves.
Department of Urology, Toride Kyodo Hospital.
H
H
Nagamatsu
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T
Matsumura
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M
Wakui
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010243:Paralysis / Q000139:chemically induced*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D012584:Sciatic Nerve / Q000187:drug effects*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D004317:Doxorubicin; C027260:pirarubicin; D002945:Cisplatin