[Clinical assessment of complement activation and leukocyte kinetics during cardiopulmonary bypass: the effect of cepharanthine].
Complement activation and leukosequestration to the lung was studied during cardiopulmonary bypass in eleven patients undergoing cardiac operation without blood transfusion. Six patients (group I) received methylprednisolone before and after the bypass, and the other five (group II) received cepharanthine (biscoclaurin alkaloid) before the bypass associated with methylprednisolone therapy. Leukosequestration to the lung was observed at the time of reperfusion of the lung only in group I, although complement activation estimated by the increase of C 4 a and C 3 a was quite similar in both group. Cepharanthine prevented the sequestration of the leukocyte to the lung may be by its membrane stabilizing effect.
Department of Cardiovascular Surgery, Kyushu University, Fukuoka, Japan.
M
M
Masuda
R
R
Tominaga
A
A
Nokashima
H
H
Mayumi
S
S
Morita
H
H
Kono
M
M
Hisahara
K
K
Fukae
K
K
Miyamoto
Y
Y
Kawachi
D000328:Adult; D000470:Alkaloids / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D002315:Cardiopulmonary Bypass; D002465:Cell Movement / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects*; D005112:Extracorporeal Circulation; D006331:Heart Diseases / Q000601:surgery; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008875:Middle Aged; D052117:Benzodioxoles
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D044182:Benzylisoquinolines; C006947:cepharanthine; D052117:Benzodioxoles