Altered adrenocortical response under the influence of experimentally increased serum very long chain fatty acids in rats.
C 26:0/C 22:0 ratio can be experimentally increased in serum of normal rats by oral administration of hexacosanoic acid (C 26:0) or of thioridazine, an inhibitor of peroxisomal beta-oxidation. This causes a decreased corticosterone response as well as decreased mobilization of cholesterol esters in zona fasciculata interna cells following ACTH administration. Zona fasciculata interna cells and their nuclei are enlarged and contain more Feulgen DNA in thioridazine-fed rats. The similarity of adrenocortical response to inhibition of peroxisomal beta-oxidation and to C 26:0 administration points to raised VLCFA as the common factor which is also operative in many peroxisomal diseases accompanied by adrenocortical function defects.
Laboratorium voor Menselijke Anatomie en Embryologie, Vrije Universiteit Brussel, Belgium.
C
C
Van den Branden
R
R
Collumbien
F
F
Roels
G
G
Dacremont
H
H
Roels
D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000097:blood*; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013881:Thioridazine / Q000008:administration & dosage*; D015383:Zona Fasciculata / Q000166:cytology / Q000187:drug effects
D005227:Fatty Acids; D000324:Adrenocorticotropic Hormone; C017364:hexacosanoic acid; D013881:Thioridazine; D003345:Corticosterone