Pathology of hepatocellular carcinoma.
This study provides a guideline to a dynamic approach toward the diagnosis of hepatocellular carcinoma (HCC). Bile production, fibrinogen synthesis, Mallory body, fibrinogen ground-glass and abnormal glycogen bodies as a reflection of "clone" selection, and hepatitis B virus (HBV) antigen expression in tumor cells can be considered as markers for the morphological diagnosis of HCC. The demonstration in tumor cells of these diagnostic features requires a careful screening of routinely stained preparations in search of suggestive, characteristic, specific, or pathognomonic features further supplemented by ancillary techniques, such as histochemistry, immunocytochemistry, and electron microscopy.
Callea
F
F
Department of Pathology, Istituto Giannina Gaslini, Genoa, Italy.
Favret
M
M
Marino
C
C
Brisigotti
M
M
D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002999:Clone Cells / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology* / Q000556:secondary; D010641:Phenotype