Purity evaluation of 6 alpha-methylprednisolone acetate by HPLC.
A high-performance liquid chromatographic method is described for the analysis and identification of related impurities in pharmaceutical-grade 6 alpha-methylprednisolone acetate (MPA). Eight MPA impurities derived from synthesis and/or degradation processes were identified. The method is compared to other analytical procedures recently proposed for the European Pharmacopoeia.
Ciranni Signoretti
E
E
Istituto Superiore di Sanità, Roma, Italy.
Valvo
L
L
Savella
A L
AL
Cavina
G
G
D002851:Chromatography, High Pressure Liquid; D008775:Methylprednisolone / Q000032:analysis / Q000592:standards*
D008775:Methylprednisolone