Oily contrast medium as a therapeutic agent for infertility because of mild endometriosis.
OBJECTIVE
To investigate the utility of using oily contrast medium (Lipiodol; Kodama, Tokyo, Japan) to treat infertility because of mild endometriosis.


METHODS
Macrophages in the peritoneal cavity of ICR mice (Japan SLC, Shizuoka, Japan) were induced by administering OK-432 to simulate the condition of the peritoneal cavity of patients with mild endometriosis, and the pregnancy rate was examined after administration of Lipiodol and/or danazol (Bonzol; Tokyo Tanabe, Tokyo, Japan). Interleukin-1 beta (IL-1 beta), prostaglandin (PG)F2 alpha (PGF2 alpha), and PGE2 levels in the supernatant were measured after incubating macrophages of mice with Lipiodol and/or danazol.


METHODS
Pregnancy rate (PR) and IL-1 beta, PGF2 alpha, and PGE2 levels.


RESULTS
The PR of the Lipiodol group was significantly increased compared with that in control mice. Prostaglandin F2 alpha level in the supernatant was significantly increased, whereas that of IL-1 beta was reduced after incubation with Lipiodol.


CONCLUSIONS
Lipiodol may elevate PGF2 alpha level and reduce IL-1 beta level in the peritoneal cavity, and this drug may increase the PR of ICR mice.
Department of Obstetrics and Gynecology, Kinki University, School of Medicine, Osaka, Japan.
Y
Y
Sawatari
T
T
Horii
H
H
Hoshiai
D000818:Animals; D002478:Cells, Cultured; D003613:Danazol / Q000627:therapeutic use; D015237:Dinoprost / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D004715:Endometriosis / Q000150:complications*; D005260:Female; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D007375:Interleukin-1 / Q000032:analysis; D007459:Iodized Oil / Q000627:therapeutic use*; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010529:Peritoneal Cavity / Q000166:cytology; D010844:Picibanil / Q000494:pharmacology; D011247:Pregnancy
D007375:Interleukin-1; D010844:Picibanil; D007459:Iodized Oil; D015237:Dinoprost; D015232:Dinoprostone; D003613:Danazol