[Stimulating effect of dietary fiber on fecal excretion of polychlorinated dibenzofurans (PCDF) and polychlorinated dibenzo-p-dioxins (PCDD) in rats].
We investigated the stimulating effect of dietary fiber on fecal excretion of PCDF and PCDD stored in the rat body. Twenty-eight male rats (71-74g body weight) were orally administered with 1ml of the causal rice oil of Yusho desease. The rice oil was contaminated with 2, 3, 4, 7, 8-pentaCDF (691.4ng), 1, 2, 3, 4, 7, 8-hexaCDF (708.6ng), 1, 2, 3, 6, 7, 8-hexaCDF (128.4ng), 1, 2, 3, 7, 8-pentaCDD (7.2ng), 1, 2, 3, 6, 7, 8-hexaCDD (34.1ng), 1, 2, 3, 7, 8, 9-hexaCDD (20.1ng) and 1, 2, 3, 4, 6, 7, 8-heptaCDD (115.9ng). The animals were fed a control diet containing 10% cellulose for seven days. Twenty-eight rats consisting of four rats a group were housed and rats of each group were given a treatment diet containing 10% rice-bran-fiber (RBF), 5% cholestyramine, 10% RBF + 5% cholestyramine, 10% RBF + 5% cholestyramine + 1% squalane, 10% burdock-fiber, 10% corn-fiber and 10% soybean-fiber during a period from eight to twenty-one days. The remaining four rats served as controls. PCDF and PCDD in feces, liver, small intestine and gastrointestinal tract were analyzed by high resolution gas chromatography-mass spectrometry. PCDF level in small intestine of rats administered with RBF + cholestyramine showed a decrease of 40% over the level of control rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Morita
K
K
Fukuoka Institute of Health and Environmental Sciences.
Hirakawa
H
H
Matsueda
T
T
Iida
T
T
Tokiwa
H
H
D000818:Animals; D001572:Benzofurans / Q000493:pharmacokinetics* / Q000506:poisoning; D004043:Dietary Fiber / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D008297:Male; D012275:Oryza; D011041:Poisoning / Q000178:diet therapy; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011108:Polymers / Q000493:pharmacokinetics* / Q000506:poisoning; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical
D001572:Benzofurans; D004043:Dietary Fiber; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; C016068:polychlorodibenzofuran