Evaluation of the 13CO2 kinetics in humans after oral application of sodium bicarbonate as a model for breath testing.
The kinetics of 13CO2 have been investigated following oral administration at five doses between 12.5 and 100 mg of 13C labelled sodium bicarbonate to 10 healthy subjects in a randomized study. Sodium bicarbonate in this study served as a model compound for carbon dioxide/bicarbonate generated in breath tests. Exhalation of 13CO2 into breath was monitored by stable isotope ratio mass spectrometry. The kinetics of 13CO2 were characterized by an apparent terminal elimination half-life of 1 h and a mean recovery of 0.630 of the dose administered. The kinetics were not dose-dependent. These results were in agreement with the findings reported previously after i.v. application of sodium bicarbonate.
Department of Clinical Pharmacology, University of Göttingen, Germany.
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Meineke
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De Mey
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Eggers
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Bauer
D000284:Administration, Oral; D000328:Adult; D001639:Bicarbonates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001944:Breath Tests; D002245:Carbon Dioxide / Q000378:metabolism*; D002247:Carbon Isotopes; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012964:Sodium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D002247:Carbon Isotopes; D002245:Carbon Dioxide; D017693:Sodium Bicarbonate; D012964:Sodium