G-proteins involved in the calcium channel signalling system.
Various mechanisms have been identified by which hormones and neurotransmitters interacting with seven transmembrane alpha-helical spanning segments receptors modulate the activity of ion channels. All of the mechanisms involve heterotrimeric G-proteins; the best documented are hormonal modulations of voltage-dependent Ca2+ channels in cardiac, neuronal and endocrine cells. Recent studies using antisense oligonucleotide probes allow the exact identification of the G-proteins involved in these signal transduction pathways.
Pharmakologisches Institut, Freie Universität Berlin, Germany.
J
J
Hescheler
G
G
Schultz
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
D015220:Calcium Channels; D019204:GTP-Binding Proteins