A recently recognized entity associated with the treatment of acute promyelocytic leukemia: the retinoic acid syndrome.
All-trans-retinoic acid is an effective induction treatment for acute promyelocytic leukemia. Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome". We describe this syndrome, which occurred in one of our patients and was successfully treated by the administration of dexamethasone.
Marinakis
T
T
Department of Pathologic Physiology, Athens University School of Medicine, Laiko General Hospital, Greece.
Papadimitriou
C A
CA
Koufos
C
C
Fertakis
A
A
D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000188:drug therapy*; D007958:Leukocyte Count; D008297:Male; D012074:Remission Induction; D013577:Syndrome; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D014212:Tretinoin; D003907:Dexamethasone