Persistence of human papillomavirus type 6e in adult multiple laryngeal papilloma and the counterpart false cord of an interferon-treated patient.
Human papillomavirus (HPV) type 6e DNA was detected in a laryngeal papilloma, in a papilloma recurring after an interval of six years and in the counterpart clinically-normal false cord of the same patient. No detectable subgroup change of HPV DNA occurred during the clinical course, which included therapy by CO2 laser followed by intramuscular alpha-interferon injection. The data demonstrated a single subtype of HPV to have persisted, and the prevention of a recurrence of laryngeal papilloma during our patient's long clinical course to have failed, in spite of the interferon treatment.
Department of Molecular Virology, Institute of Molecular and Cellular Biology, Okayama.
H
H
Ogura
S
S
Watanabe
K
K
Fukushima
Y
Y
Baba
Y
Y
Masuda
T
T
Fujiwara
Y
Y
Yabe
D000328:Adult; D003131:Combined Modality Therapy; D015344:DNA Probes, HPV; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007820:Laryngeal Mucosa / Q000382:microbiology; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D017075:Laser Coagulation; D008297:Male; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D027383:Papillomaviridae / Q000302:isolation & purification; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery
D015344:DNA Probes, HPV; D016898:Interferon-alpha