Human herpesvirus-6 and Epstein-Barr virus genome in primary cerebral lymphomas.
Using dot blotting, we found Epstein-Barr virus genome in three AIDS-related primary cerebral lymphomas (PCLs), but in none of 39 sporadic PCLs. Human herpesvirus-6 sequences were present only in one sporadic PCL, as revealed by polymerase chain reaction and Southern analysis. We conclude that these viruses do not appear to play a major role in PCL pathogenesis in immunocompetent subjects.
Institute of Pathology, University of Würzburg, Germany.
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Paulus
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Jellinger
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Hallas
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Ott
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Müller-Hermelink
D000368:Aged; D000595:Amino Acid Sequence; D001932:Brain Neoplasms / Q000235:genetics* / Q000382:microbiology; D005260:Female; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000235:genetics* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data