A recurring translocation, t(11;22)(p13;q11.2), characterizes intra-abdominal desmoplastic small round-cell tumors.
We report the cytogenetic analysis of two cases of intra-abdominal desmoplastic small round-cell tumor, one of which had a t(11;22)(p13;q11.2) translocation. The same translocation has previously been reported in two other cases analyzed cytogenetically, indicating that it could be a consistent abnormality characteristic of this rare tumor entity.
Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
E
E
Rodriguez
C
C
Sreekantaiah
W
W
Gerald
V E
VE
Reuter
R J
RJ
Motzer
R S
RS
Chaganti
D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D003131:Combined Modality Therapy; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic