[The anticonvulsive activity of the 1,4-dihydropyridine derivative riodipine and other anticonvulsants when used in combination].
The anticonvulsant efficacy of combinations of novel calcium antagonist ryodipine with known antiepileptic drugs of different classes was studied in the experiments in mice using the maximal electroshock seizure test, and isobolographic analysis method for the development of complex pathogenetic therapy (CPT) of epilepsy. The synergetic potentiation effect was obtained in all drug combinations. In combinations of ryodipine with sodium valproate, diazepam, carbamazepine, phenytoin, ethosuximide and phenobarbital by 30-, 15-, 10-, 8-, 7-, and 5-fold respectively decreased. The experimental data suggest that the suppression of Ca2+ entry mechanism (ryodipine effect) in complex with the influence on other epileptogenesis mechanisms results in a marked potentiation of the antiepileptic effect. CPT of epilepsy which can provide potentiation of effects of each drug and a significant reduction of their doses is regarded to be expedient.
Kryzhanovskiĭ
G N
GN
Karpova
M N
MN
Abrosimov
I Iu
IIu
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004597:Electroshock; D051379:Mice; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy
D000927:Anticonvulsants; D009543:Nifedipine; C045912:ryodipine