Marked species-difference in the vascular angiotensin II-forming pathways: humans versus rodents.
Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensin II formation was ascribed to chymostatin-sensitive angiotensin II-generating enzyme (CAGE). On the contrary, angiotensin II formation in rodent arteries totally depended upon ACE, without any sign of CAGE involvement. Such a marked species-difference can be relevant to the reported difference between humans and rodents in the ACE inhibitor effects on the myointimal hyperplasia after intimal balloon injury.
Department of Pharmacology, Osaka Medical College, Japan.
H
H
Okunishi
Y
Y
Oka
N
N
Shiota
T
T
Kawamoto
K
K
Song
M
M
Miyazaki
D000328:Adult; D000368:Aged; D000803:Angiotensin I / Q000378:metabolism; D000804:Angiotensin II / Q000096:biosynthesis*; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D002216:Captopril / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000378:metabolism; D013045:Species Specificity
D009842:Oligopeptides; D000804:Angiotensin II; D000803:Angiotensin I; C002101:chymostatin; D002216:Captopril; D012697:Serine Endopeptidases; C054542:chymostatin-sensitive angiotensin II-generating enzyme