Combined anti-fungal therapy and surgical resection as treatment of disseminated aspergillosis of the lung and brain following BMT.
This report describes a 6-year-old girl with pre-B ALL who developed systemic aspergillosis following BMT. She was successfully treated with a combination of amphotericin B, itraconazole and surgery. This report emphasizes the importance of surgical resection in the management of disseminated aspergillosis.
Trigg
M E
ME
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.
Menezes
A H
AH
Giller
R
R
Lanza
L
L
Smith
R J
RJ
Sato
Y
Y
Peters
C
C
Altman
A
A
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery*; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D007654:Ketoconazole