T cell fibronectin and mycobacterial adversarial strategy.
Sensitized T cells synthesize and secrete a biochemically and functionally distinct cellular fibronectin in response to antigenic stimulation. This T cell fibronectin is associated with initiation of in vivo delayed hypersensitivity inflammatory reactions. Mycobacterial secretory proteins of the fibronectin-binding antigen 85 complex can bind and inactivate T cell fibronectin, and diminish expression of anti-mycobacterial delayed hypersensitivity. Interaction of T cell fibronectin and antigen 85 provides an additional possible mechanism for tuberculin anergy in patients with clinical tuberculosis.
New York Medical College, Department of Experimental Pathology, Valhalla 10595.
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Godfrey
D000941:Antigens / Q000096:biosynthesis; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism*
D000941:Antigens; D005353:Fibronectins