Hydroxyl free radical (.OH) formation reflected by salicylate hydroxylation and neuromelanin. In vivo markers for oxidant injury of nigral neurons.
Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center 10/Rm 3D-41, Bethesda, Maryland 20892.
C C
CC
Chiueh
D L
DL
Murphy
H
H
Miyake
K
K
Lang
P K
PK
Tulsi
S J
SJ
Huang
D000818:Animals; D015415:Biomarkers; D004298:Dopamine / Q000378:metabolism; D016166:Free Radical Scavengers; D005609:Free Radicals / Q000032:analysis; D006878:Hydroxides / Q000032:analysis / Q000378:metabolism*; D017665:Hydroxyl Radical; D006900:Hydroxylation; D008543:Melanins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D012459:Salicylates / Q000494:pharmacology*; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology*
D015415:Biomarkers; D016166:Free Radical Scavengers; D005609:Free Radicals; D006878:Hydroxides; D008543:Melanins; D012459:Salicylates; C014121:neuromelanin; D017665:Hydroxyl Radical; D004298:Dopamine