[An experimental study of a new embolic material--Lipiodol suspension of water-absorbent particle].
A water-absorbent particle (a polymer of polyacrylic acid soda) was investigated as a new embolic material. The size of a single particle is 200 microns (N-100) or 10 microns (NP-1010). A particle absorbs 100 times its own weight of physiologic NaCl solution within a few seconds. The particles have no acute or chronic toxicity or immunogenicity. This material suspended by Lipiodol was evaluated in an in vitro study using an AVM model composed of a plastic syringe and polyurethane sponge. The AVM model was perfused by physiological NaCl solution at a pressure of 150 mmHg. The swollen polymer worked as an adequate embolic material in the AVM model, using a minimum quantity. The embolic effect depended upon the quantity and concentration of the suspension. Restoration of flow was not observed within a period of ten minutes. The embolized part was clearly visualized due to the retention of Lipiodol. This material is a promising agent for arterial embolization.
Department of Radiology, Osaka University Medical School.
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S
Hori
S
S
Maeshima
K
K
Tomoda
T
T
Hashimoto
T
T
Ishida
T
T
Mitani
T
T
Murakami
K
K
Nakanishi
H
H
Nakamura
T
T
Kozuka
D000042:Absorption; D000180:Acrylic Resins; D001165:Arteriovenous Malformations / Q000628:therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D007459:Iodized Oil; D008961:Models, Structural; D014867:Water
D000180:Acrylic Resins; D014867:Water; C006903:carbopol 940; D007459:Iodized Oil