Pertussis toxin sensitive photoaggregation of pigment in isolated Xenopus tail-fin melanophores.
Direct illumination of Xenopus laevis tail-fin melanophores results in rapid, reversible translocation of intracellular pigment granules to a perinuclear location, an effect distinct from and opposite to the photodispersion of pigment found in melanophores isolated from Xenopus embryos. In this report we show that both pertussis toxin and dibutyryl-adenosine-3',5'-monophosphate block the ability of light to cause photoaggregation of pigment in cultured tail-fin melanophores, whereas dibutyryl-guanosine-3',5'-monophosphate is without effect.
Rollag
M D
MD
Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology; D008027:Light; D008547:Melanophores / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D037342:Pertussis Toxin; D010860:Pigments, Biological / Q000378:metabolism*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*; D014982:Xenopus laevis
D010860:Pigments, Biological; D010566:Virulence Factors, Bordetella; D003995:Dibutyryl Cyclic GMP; D003994:Bucladesine; D000242:Cyclic AMP; D037342:Pertussis Toxin; D006152:Cyclic GMP