Passive antibody protection of cats against feline immunodeficiency virus infection.
All six cats passively immunized with sera from either feline immunodeficiency virus (FIV)-vaccinated cats or cats infected with FIV (Petaluma strain) were protected from homologous FIV infection at a challenge dose that infected all six control cats. Passive immunization with sera from cats vaccinated with uninfected allogeneic T cells used to grow the vaccine virus did not protect either of two cats against the same FIV challenge. These results suggest that antiviral humoral immunity, perhaps in synergy with anticellular antibodies, may be responsible for previously reported vaccine protection.
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
T
T
Hohdatsu
R
R
Pu
B A
BA
Torres
S
S
Trujillo
M B
MB
Gardner
J K
JK
Yamamoto
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage* / Q000276:immunology; D002415:Cats; D016181:Feline Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D007116:Immunization, Passive; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D009500:Neutralization Tests; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; D014765:Viral Vaccines