Twin genes and endocrine disease: CYP21 and CYP11B genes.
CYP21 and CYP11B genes have a common feature: they are "twin" genes. It seems as if doubling and subsequent drifting apart rendered these genes particularly sensitive to defect acquisition by mechanisms involving recombinatorial events. This creates specific difficulties in the molecular diagnosis of defects.
Helmberg
A
A
Department of Molecular Biology, University of Innsbruck Medical School, Austria.
D000312:Adrenal Hyperplasia, Congenital; D000595:Amino Acid Sequence; D004700:Endocrine System Diseases / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D013252:Steroid 11-beta-Hydroxylase / Q000235:genetics*; D013255:Steroid 21-Hydroxylase / Q000235:genetics*
D013255:Steroid 21-Hydroxylase; D013252:Steroid 11-beta-Hydroxylase