The combined immunological and antinociceptive defects of beige-J mice: the possible existence of a 'mu-repressin'.
A selective non-responsiveness to the analgesic effects of opioid mu receptor-, but not opioid delta receptor-, mediated antinociception in the tail-flick test has been identified in C57BL/6J-bgJ (beige-J) mice. The beige-J mutation is also known to give rise to multiple immunological disorders and immune cell dysfunctions. A link between these apparently disparate manifestations has been examined in a series of studies using, for example, adoptive transfer of spleen cells. The findings appear to have broad implications for the link between the immune and opioid systems.
Raffa
R B
RB
Drug Discovery Research, R.W. Johnson Pharmaceutical Research Institute, PA 19477-0776.
Mathiasen
J R
JR
Kimball
E S
ES
Vaught
J L
JL
D000818:Animals; D007109:Immunity / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology* / Q000502:physiology*; D010146:Pain / Q000235:genetics* / Q000503:physiopathology; D017465:Receptors, Opioid, delta / Q000235:genetics; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000235:genetics*
D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu