Radical ions and their reactions in DNA constituents: ESR/ENDOR studies of radiation damage in the solid state.
This updating review contains the results of recent ESR/ENDOR experiments on DNA constituents in the solid state. The compounds reviewed include single crystals of the DNA bases, nucleosides, and nucleotides. The emphasis is on low-temperature ENDOR results. Typical experiments involve irradiations at or near helium temperatures in attempts to determine the primary radiation-induced oxidation and reduction products. The use of the ENDOR technique allows one to determine the protonation state of the initial products. Subsequent warming of the sample facilitates a study of the reactions that these primary products undergo. A critical review of previous ESR experiments is considered to see if these results conflict with the newer ENDOR results. Finally, a summary is provided to show which of the numerous results discussed may have some relevance to understanding the radiation chemistry of DNA.
Physics Department, East Tennessee State University, Johnson City 37614.
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D004247:DNA / Q000737:chemistry / Q000528:radiation effects*; D004249:DNA Damage; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D011687:Purines / Q000737:chemistry / Q000528:radiation effects; D011743:Pyrimidines / Q000737:chemistry / Q000528:radiation effects
D005609:Free Radicals; D011687:Purines; D011743:Pyrimidines; D004247:DNA