The effects of long term fadrozole hydrochloride treatment in patients with advanced stage breast cancer.
Fadrozole hydrochloride at a dose of 2 mg b.i.d. has been shown to be an effective aromatase inhibitor in advanced stage breast cancer patients as determined by its ability to significantly suppress endogenous estrogen biosynthesis over a 12-week period. Continued suppression of circulating estrogen levels over a prolonged period has not yet been examined in published reports. In this study, we report the extended use of fadrozole hydrochloride at a maintenance dose of 2 mg b.i.d. in a cohort of 11 patients extending to 973 days of therapy. Results show that the degree of suppression of plasma and urinary estrogens was maintained in all patients throughout the extended period of drug use. Continued estradiol suppression of over 50% or greater from baseline was observed, as was continued suppression of estrone to over 80% from baseline. Cortisol determinations after 9 months of treatment showed no suppression from baseline. The aldosterone values and responses to cortrosyn stimulation continued to be suppressed as first noted following the initial 3 months of the core clinical trial. Objective tumor response noted in the core clinical trial did not change until disease progression. These findings suggest that fadrozole hydrochloride maintains its ability to suppress the aromatase enzyme during long term use. No observable escape from suppression of plasma and urinary estrogens occurred during prolonged treatment.
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
L M
LM
Demers
A
A
Lipton
H A
HA
Harvey
J
J
Hanagan
M
M
Mulagha
R J
RJ
Santen
D000324:Adrenocorticotropic Hormone; D000450:Aldosterone / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000652:urine; D004958:Estradiol / Q000097:blood / Q000652:urine; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood / Q000652:urine; D017316:Fadrozole / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D009367:Neoplasm Staging
D004970:Estrone; D000450:Aldosterone; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D017316:Fadrozole; C017296:estrone sulfate; D006854:Hydrocortisone