The course of preexistent immune abnormalities in HIV negative haemophiliacs treated for two years with a monoclonal purified factor VIII concentrate.
The administration of factor VIII concentrates has been associated with immune abnormalities in patients with severe haemophilia A, even in the absence of HIV infection. The effects of a monoclonal purified factor VIII concentrate, Hemofil M (Baxter), on preexistent immune abnormalities were assessed over a 2 year period in 22 HIV negative haemophiliacs. They were treated previously with other concentrates, and received Hemofil T from 1983 to 1988. No HIV infection was demonstrated. No serologic evidence for other viral (re)-infections was seen. A decrease of HLA-DR expression on non-B lymphocytes in the first year (P = 0.026), and a decrease of T4-T8 ratio over the 2 years were found (P = 0.0016). Skin tests were non-contributive. The decrease in HLA-DR expression is suggestive for an improved immune function, possibly due to a reduced content of protein or virus in this concentrate.
Department of Haematology, University Hospital Groningen, The Netherlands.
W M
WM
Smid
J
J
van der Meer
J W
JW
Smit
M R
MR
Halie
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D002648:Child; D005169:Factor VIII / Q000009:adverse effects* / Q000302:isolation & purification / Q000627:therapeutic use; D005500:Follow-Up Studies; D006679:HIV Seropositivity; D006684:HLA-DR Antigens / Q000032:analysis; D006467:Hemophilia A / Q000150:complications / Q000276:immunology* / Q000628:therapy; D006509:Hepatitis B / Q000150:complications; D006566:Herpesviridae Infections / Q000150:complications; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D007163:Immunosorbent Techniques; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D005169:Factor VIII