[Importance of systemic administration of pyrimidine after thermochemotherapy].
Warmed (47 degrees C) 5 to 10% glucose solution with the addition of 0.05 mg of noradrenaline (PTCT) was administered after chemotherapy (MMC 2-10 mg or CDDP 10 mg) into tumor feeding artery of liver tumors (17 cases) and pancreas tumors (8 cases). Efficacy was noted in 14 cases with liver tumor (14/17 82.3%) and in 4 cases with pancreas tumor (4/8 50%). The metastatic rate in the PTCT with systemic administration of pyrimidine (5-FU: 100-300 mg or FT-207: 1,000 mg) was 0% (0/10) compared with 45.5% in controls (5/11) (p = 0.023). Thus, systemic administration of 5-FU or FT-207 after thermochemotherapy can prevent distant metastasis.
Dept. of Surgery, Koriyama National Hospital.
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Satou
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D005770:Gastrointestinal Neoplasms / Q000628:therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008113:Liver Neoplasms / Q000628:therapy*; D016685:Mitomycin / Q000008:administration & dosage; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009638:Norepinephrine / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000628:therapy*; D011743:Pyrimidines / Q000627:therapeutic use*
D011743:Pyrimidines; D016685:Mitomycin; C030986:pyrimidine; D002945:Cisplatin; D005472:Fluorouracil; D009638:Norepinephrine