Skeletal growth after oral administration of demineralized bone matrix.
Oral administration of bone extracts obtained from bovine demineralized bone matrix to rats has a direct effect on bone metabolism, affecting bone proportions and some markers of bone formation such as bone malate dehydrogenase, serum alkaline phosphatase and serum osteocalcin. Furthermore collagen deposition, bone protein synthesis and nucleic acids content were significantly increased by the treatment.
Martínez
J A
JA
Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain.
Elorriaga
M
M
Marquínez
M
M
Larralde
J
J
D000284:Administration, Oral; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001846:Bone Development / Q000187:drug effects*; D001857:Bone Matrix / Q000737:chemistry; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002364:Caseins / Q000494:pharmacology; D002417:Cattle; D003094:Collagen / Q000032:analysis; D016326:Extracellular Matrix Proteins / Q000008:administration & dosage / Q000494:pharmacology; D006133:Growth Substances / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008291:Malate Dehydrogenase / Q000032:analysis; D008297:Male; D008437:Maxilla / Q000737:chemistry; D009696:Nucleic Acids / Q000096:biosynthesis; D009929:Organ Size / Q000187:drug effects; D015675:Osteocalcin / Q000097:blood; D010758:Phosphorus / Q000097:blood; D010865:Pilot Projects; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar; D014020:Tissue Extracts / Q000008:administration & dosage / Q000494:pharmacology*
D015415:Biomarkers; D002364:Caseins; D016326:Extracellular Matrix Proteins; D006133:Growth Substances; D009696:Nucleic Acids; D014020:Tissue Extracts; D015675:Osteocalcin; D010758:Phosphorus; D003094:Collagen; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D002118:Calcium