Blockade of brain bombesin/GRP receptors increases food intake in satiated rats.
The mechanisms that initiate or terminate a meal remain obscure. Bombesin (BN) and gene-related peptides (GRP) have been reported to induce a satiety-like state in several species including fowl, mouse, rat, wolf, pig, baboon, and humans. The evolutionary conservation of this pharmacological response suggests a physiological role for the endogenous BN-like peptide(s) in the regulation of food intake. If the release of BN-like peptide(s) represents a "satiety signal" then pharmacological antagonism of this action should enhance food intake and/or postpone satiety. We report herein 1) that [Leu14, psi 13-14]-BN, a BN receptor antagonist, blocks the suppressive effect of centrally administered BN on food intake and 2) that in satiated rats, this pseudopeptide enhances food intake; the effects were more potent and efficacious upon the fourth compared with the third ventricular administration. These results support the contention that endogenous BN-like peptides mediate satiety and that this effect involves brain BN receptors in the caudal brain stem site(s).
Merali
Z
Z
School of Psychology, University of Ottawa, Ontario, Canada.
Moody
T W
TW
Coy
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001839:Bombesin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000502:physiology; D004435:Eating / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018004:Receptors, Bombesin; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors*; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology*
D018004:Receptors, Bombesin; D017981:Receptors, Neurotransmitter; C067901:bombesin, Psi(13,14)-Leu(14)-; D001839:Bombesin