Neuropathic findings in oculopharyngeal muscular dystrophy. A report of seven cases and a review of the literature.
We describe seven patients with clinical evidence of oculopharyngeal muscular dystrophy. Four of these patients were members of the same Italian-American family. The age at onset was after the fourth decade in all patients. All seven patients had extraocular muscle involvement, and six of the seven patients had clinical, electrophysiological, and/or pathological evidence of neuropathy in addition to features that were suggestive of myopathy. An autopsy was performed on one patient. We discuss the significance of the concurrence of neuropathic features with oculopharyngeal muscular dystrophy in relation to these patients and previously reported cases.
Hardiman
O
O
Harvard Longwood Area Neurological Training Program, Beth Israel Hospital, Boston, Mass.
Halperin
J J
JJ
Farrell
M A
MA
Shapiro
B E
BE
Wray
S H
SH
Brown
R H
RH
D000368:Aged; D001763:Blepharoptosis / Q000209:etiology / Q000235:genetics / Q000473:pathology; D003680:Deglutition Disorders / Q000209:etiology / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000294:innervation / Q000473:pathology; D009136:Muscular Dystrophies / Q000150:complications* / Q000235:genetics / Q000473:pathology; D009801:Oculomotor Muscles / Q000294:innervation; D009886:Ophthalmoplegia / Q000209:etiology / Q000235:genetics / Q000473:pathology; D010375:Pedigree; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D010608:Pharyngeal Diseases / Q000209:etiology* / Q000235:genetics / Q000473:pathology