[Treatment of cancer by intraperitoneal infusion of anticancer drugs using an anti-adhesion sheet connected with a subcutaneously implanted reservoir].
Intraperitoneal infusion of anticancer drugs via a catheter fitted with a subcutaneously implanted reservoir, when repeated frequently, usually becomes increasingly more difficult to perform owing to the catheter's becoming more and more clogged. Moreover, intraperitoneally administered anticancer drugs give rise to severe intestinal adhesions, which in turn interfere with rapid, even and widespread diffusion of the infused drugs in the peritoneal cavity. With the aim of overcoming the difficulties and inconveniences with conventionally used apparatuses for the intraperitoneal administration of drugs, we tentatively manufactured a new apparatus for intraperitoneal drug infusion. A special protective sheet, devised by Tanaka, for the prevention of postoperative intestinal adhesion following abdominal surgery, is connected with a reservoir to be implanted in the subcutis. The apparatus is inserted into the peritoneal cavity of gastric patients with peritoneal dissemination to allow it to remain in place therein. Treatment with anticancer drugs administered intraperitoneally with the use of this device proved apparently more successful than without it, resulting in improvement of QOL, disappearance of ascites, shrinkage in the size of tumor mass and depressed serum levels of a tumor marker, CA 19-9. The sheet was thus found to have the advantages of permitting safe repeated administration of anticancer drugs, even and extensive drug delivery to the peritoneal cavity, sampling of intraperitoneal cancer cells and ascitic fluid without inconvenience, and easy-to-perform continual infusion of anticancer drugs at the outpatient service.
Dept. of Surgery, Tokyo Dental College, Ichikawa General Hospital.
T
T
Tanaka
Y
Y
Kawasaki
H
H
Ishikawa
Y
Y
Oomori
Y
Y
Takenaka
S
S
Ono
K
K
Yoshino
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006801:Humans; D015918:Infusion Pumps, Implantable; D007263:Infusions, Parenteral; D007410:Intestinal Diseases / Q000517:prevention & control; D008297:Male; D011482:Protective Devices; D013274:Stomach Neoplasms / Q000188:drug therapy*; D000267:Tissue Adhesions / Q000517:prevention & control
D000970:Antineoplastic Agents