Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency.
In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE4 (n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease.
University Children's Hospital, Heidelberg, Germany.
E
E
Mayatepek
G F
GF
Hoffmann
H J
HJ
Bremer
D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D017999:Leukotriene E4; D008297:Male; D008798:Mevalonic Acid / Q000652:urine; D010770:Phosphotransferases / Q000172:deficiency*; D017853:Phosphotransferases (Alcohol Group Acceptor); D013189:SRS-A / Q000031:analogs & derivatives* / Q000652:urine; D014556:Urine / Q000166:cytology
D013189:SRS-A; D017999:Leukotriene E4; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C021796:mevalonate kinase; D008798:Mevalonic Acid