Wilms tumor and nephroblastomatosis: imaging characteristics at gadolinium-enhanced MR imaging.
Twelve children with Wilms tumors were prospectively evaluated with 1.5-T magnetic resonance (MR) imaging. Spin-echo images were obtained before and after administration of gadopentetate dimeglumine. Nine of the 12 children had histologically proved nephroblastomatosis or nephrogenic rests involving a total of 14 kidneys. MR imaging depicted involvement in eight of these kidneys, including five of five kidneys with lesions contralateral to the primary Wilms tumor. Overall sensitivity of detection of nephrogenic rests was 43% on nonenhanced images and 58% when gadolinium-enhanced images were added. Nephrogenic rests admixed with Wilms tumors less than 4 mm in diameter were not depicted at MR imaging. On gadolinium-enhanced T1-weighted images, Wilms tumors and hyperplastic were hypointense to normal renal tissue. On T2-weighted images, Wilms tumors and hyperplastic nephrogenic rests were iso- or slightly hyperintense to renal cortex, while sclerotic nephrogenic rests were hypointense to renal cortex. On all images, including gadolinium-enhanced T1-weighted images, the signal intensity of Wilms tumors was inhomogeneous, while the signal intensity of nephrogenic rests was homogeneous.
Department of Radiology, Children's Hospital, Boston, MA.
V
V
Gylys-Morin
F A
FA
Hoffer
H
H
Kozakewich
R C
RC
Shamberger
D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D007223:Infant; D007680:Kidney Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011446:Prospective Studies; D009396:Wilms Tumor / Q000175:diagnosis*
D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA