Laminin matrix formation and S-100 protein and/or desmin-positive cells in malignant fibrous histiocytoma (MFH).
16/30 human storiform-pleomorphic malignant fibrous histiocytomas (MFH) showed a focal pericellular immunostaining for laminin. 14/16 of these laminin-positive tumours additionally revealed an atypical cellular differentiation (desmin- and/or S-100 protein-positive cells). The significance of focal laminin positivity along with atypical, non-entity specific differentiated cells is discussed before the background of laminin as being an indicator and promoter of differentiation in MFH. The limited value of a laminin detection in MFH for solving differential diagnostic questions (MFH versus other poorly differentiated sarcomas with basement membrane formation) has been pointed out.
Kosmehl
H
H
Institute of Pathology, Friedrich Schiller University, Jena, FRG.
Langbein
L
L
Katenkamp
D
D
Vogel
W
W
Berndt
A
A
D002454:Cell Differentiation; D003893:Desmin / Q000276:immunology / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000378:metabolism*; D016612:Paraffin Embedding; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism*
D003893:Desmin; D007797:Laminin; D009418:S100 Proteins