Screening for disulfiram-induced liver test dysfunction in an inpatient alcoholism program.
The objective of this study was to report the frequency of disulfiram-related elevations of four commonly used hepatic screening chemistries using a retrospective record review design. An inpatient alcoholism program was selected for the setting. Patients who had initial laboratory values within the normal range started daily supervised doses of disulfiram, then underwent follow-up testing after 2 and 4 weeks on the drug. The study population consisted of 108 patients receiving disulfiram and 27 patients who did not receive disulfiram (controls). The four screening serum chemistries performed were aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT), alkaline phosphatase, and gamma-glutamyl transferase. Twenty-seven (25%) of the 108 patients who were taking 250 mg of disulfiram a day for 2 to 4 weeks had disulfiram-related elevations in alanine aminotransferase above the upper limit of normal, as opposed to one elevation in 27 patients (4%) for whom disulfiram was not prescribed. In the 108 patients (with initially normal serum chemistries) who were prescribed disulfiram, 32 were discontinued from the drug at 2 weeks and an additional 11 were discontinued from the drug at 4 weeks because of one or more abnormal serum chemistries. Alanine aminotransferase was the most specific and sensitive indicator of the four screening chemistries performed.
Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857.
C
C
Wright
R D
RD
Moore
D M
DM
Grodin
D A
DA
Spyker
E V
EV
Gill
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000534:rehabilitation*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000517:prevention & control*; D004221:Disulfiram / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004798:Enzymes / Q000097:blood; D005260:Female; D006760:Hospitalization; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008403:Mass Screening; D011446:Prospective Studies; D012307:Risk Factors; D016320:Substance Abuse Treatment Centers
D004798:Enzymes; D004221:Disulfiram