[Comparative effectiveness of some medicinal substances as acceptors of superoxide radicals].
The effect of about 30 medicines and some other compounds on the yield of the riboflavin sensitized glycyltryptophan photochemiluminescence occurring at the participation of superoxide and glycyltryptophan peroxide free radicals in solution has been studied. Some of the investigated compounds decrease the chemiluminescence yield as a result of their reactions with superoxide and gly-try peroxide radicals. The concentrations of compounds decreasing the chemiluminescence yield by 2 times were obtained. The estimation of the rate constants for a few compounds is given. It is shown that rutin, quercetin, ascorbic acid, aethamzilat, analgin, paracetamol, serotonin and butadione are most effective among the investigated medicines.
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Sapezhinskiĭ
D004151:Dipeptides / Q000737:chemistry; D008163:Luminescent Measurements; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D017382:Reactive Oxygen Species; D013481:Superoxides / Q000378:metabolism*
D004151:Dipeptides; D004364:Pharmaceutical Preparations; D017382:Reactive Oxygen Species; D013481:Superoxides; C032120:glycyltryptophan