[Blood rheology and cognitive function in elderly patients with uncomplicated isolated systolic hypertension].
The relationship among blood pressure, blood rheology and cognitive function were evaluated in 40 elderly patients with isolated systolic hypertension (ISH) by control-case study. The cognitive function was lower in the patient group than in the control group (79.92 + 17.05 vs 91.24 + 14.06, P < 0.01). Among the hypertensive patients, the weak correlations were observed between the cognitive function and systolic blood pressure (r = -0.11, P < 0.05), but the correlations were strengthened when the two groups were considered together (r = -0.44, P < 0.01). Blood viscosity at low shear rate and plasma viscosity in the patient group were greater than in the control group (P < 0.05, P < 0.01). A close relation existed between blood viscosity at low shear rate and cognitive function (r = -0.82, P < 0.01), whereas the patients with normal cognitive function had viscosity similar to that in control subjects (r = -0.20, P < 0.05). Thus, increased blood viscosity may be a determinant or a response to decrease cognitive function in the elderly patients with uncomplicated systolic hypertension.
First Affiliated Hospital, Human Medical University, Changsha.
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Cai
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Sun
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Zhan
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001809:Blood Viscosity; D003071:Cognition; D005260:Female; D006400:Hematocrit; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D013599:Systole