Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24.
The authors examined the dose response relationship between plasma ACTH and cortisol concentrations after the administration of various doses of ACTH1-24 (0.025 micrograms, 0.125 micrograms, 0.25 micrograms, 1 microgram, 250 micrograms) in dexamethasone-suppressed normal volunteers. A logarithmic dose-response relationship between the dose of ACTH administered and plasma cortisol concentration was found. Although there was considerable variability in plasma ACTH concentrations, there was, however, a definite correlation between area under the curve for ACTH and area under the curve for cortisol after the various doses of ACTH.
Krishnan
K R
KR
Department of Psychiatry, Duke University Medical Center, Durham, NC.
Miller
M N
MN
Helms
M J
MJ
Reed
D
D
Ritchie
J C
JC
Nemeroff
C B
CB
Carroll
B J
BJ
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003366:Cosyntropin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects; D012016:Reference Values
D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone