Fructose-2,6-bisphosphate level and beta-lactam formation in Penicillium chrysogenum.
The rate of penicillin formation in the medium containing lactose as sole carbon source markedly decreased after addition of glucose but at the same time the growth rate of fungal mycelium increased. Significant correlation was found between the formation of penicillin and the intracellular concentration of fructose-2,6-bisphosphate. It appears that penicillin production is influenced by the level of fructose-2,6-bisphosphate.
Department of Microbiology and Biotechnology, Kossuth Lajos University of Sciences, Debrecen, Hungary.
J
J
Kozma
G
G
Bartók
A
A
Szentirmai
D000242:Cyclic AMP / Q000378:metabolism; D005635:Fructosediphosphates / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D010406:Penicillins / Q000096:biosynthesis*; D010408:Penicillium chrysogenum / Q000378:metabolism*; D047090:beta-Lactams / Q000378:metabolism*
D005635:Fructosediphosphates; D010406:Penicillins; D047090:beta-Lactams; C027652:fructose 2,6-diphosphate; D000242:Cyclic AMP; D005947:Glucose