Hairy leukoplakia after bone marrow transplantation.
Hairy leukoplakia in 10 patients after bone marrow transplantation was identified clinically and assessed histologically. In situ hybridization for Epstein-Barr virus and human papilloma virus confirmed Epstein-Barr virus in hairy leukoplakia in two cases, and human papillomavirus in three cases. All cases with clinical follow-up resolved without treatment. These findings suggest that severe immunosuppression after a bone marrow transplantation may result in the development of hairy leukoplakia, and that as the immunosuppression resolves after the transplant the lesions also resolve.
Epstein
J B
JB
Medical/Dental Staff, British Columbia Cancer Agency, Vancouver, Canada.
Sherlock
C H
CH
Wolber
R A
RA
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D017403:In Situ Hybridization; D007972:Leukoplakia, Oral / Q000209:etiology / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology / Q000382:microbiology*; D027383:Papillomaviridae / Q000235:genetics
D004279:DNA, Viral