Mucin-producing poorly differentiated adenocarcinoma of the thyroid. A case report.
A rare case of mucin-producing poorly differentiated adenocarcinoma of the thyroid is reported in a 58-year-old man. Light microscopically, the tumor composed of columnar cells, cuboidal cells and spindle cells and these tumor cells showed a various growth pattern; glandular growth with columnar cells, microfollicular growth with cuboidal cells and solid growth with spindle cells. Mucin histochemistry showed scattered foci of mucin production. Immunohistochemistry showed a focal positive staining for thyroglobulin and carcinoembryonic antigen, but a negative staining for calcitonin throughout the tumor. The patient had cervical and axillary lymph node recurrences after the radical operation. The histologic finding of this tumor is peculiar; we report this case briefly.
Pathology Section, Kanazawa University Hospital, Japan.
Y
Y
Mizukami
H
H
Nakajima
Y
Y
Annen
T
T
Michigishi
A
A
Nonomura
S
S
Nakamura
D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009077:Mucins / Q000032:analysis*; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology*
D002272:Carcinoembryonic Antigen; D009077:Mucins; D013954:Thyroglobulin