Comparative study of renal scintigraphy with 99Tcm-mercaptoacetyltriglycine and 123I-orthoiodohippurate.
This study was undertaken to compare image quality, renal handling and plasma clearance of 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3) with those of 123I-orthoiodohippurate (123I-OIH). 99Tcm-MAG3 was prepared in-house using an instant kit vial and 123I-OIH was commercially available in a form already labelled. Both studies were undertaken in 20 patients with nephrourological disorders after intravenous (i.v.) injection of 300 MBq 99Tcm-MAG3 and 34 MBq 125I-OIH within the time interval of 3 to 4 days. 99Tcm-MAG3 was much superior to 123I-OIH in visualization of renal perfusion, renal parenchyma and urinary tract. The time parameters of the renogram, Tmax and T1/2 were significantly prolonged in 99Tcm-MAG3 compared to those for 123I-OIH (P < 0.05). Plasma clearance of 99Tcm-MAG3 was also slower than that of 123I-OIH but correlated well with that of 123I-OIH (r = 0.958, P < 0.01). The % renal uptake of 99Tcm-MAG3 per injected dose, which was calculated by the gamma camera method, also correlated well with effective renal plasma flow (ERPF) calculated by the single blood sampling method (r = 0.940, P < 0.01). The renal handling and plasma clearance of 99Tcm-MAG3 are not completely identical with those of 123I-OIH. However, 99Tcm-MAG3 has the clinical advantages of superior image quality, the feasibility of gamma camera measurement of quantitative renal uptake, and ready availability for routine clinical use.
Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
K
K
Itoh
E
E
Tsukamoto
H
H
Kakizaki
K
K
Nonomura
M
M
Furudate
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D017263:Technetium Tc 99m Mertiatide; D014570:Urologic Diseases / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide