Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium.
Serum lipid levels in rats with hyperlipidemia induced by diet as well as by Triton were determined after oral administration of EtOAc extract of Pterocarpus marsupium heartwood and its flavonoid constituents, marsupsin [1], pterosupin [2], and liquiritigenin [3]. Administration of EtOAc extract for 14 consecutive days produced a significant reduction of serum triglyceride, total cholesterol, and LDL- and VLDL-cholesterol levels without any significant effect on the level of HDL-cholesterol. Liquiritigenin and pterosupin were able to effect a significant fall in serum cholesterol, LDL-cholesterol, and atherogenic index, pterosupin being additionally effective in lowering serum triglyceride.
Department of Medicinal Chemistry, Centre of Experimental Medicine and Surgery, Banaras Hindu University, Varanasi, India.
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Jahromi
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Ray
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D003408:Cresols / Q000302:isolation & purification / Q000494:pharmacology*; D004032:Diet; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D011092:Polyethylene Glycols; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D001572:Benzofurans; D003408:Cresols; D044950:Flavanones; D005419:Flavonoids; D005960:Glucosides; D000960:Hypolipidemic Agents; D008055:Lipids; D010636:Phenols; D010936:Plant Extracts; D014280:Triglycerides; D011092:Polyethylene Glycols; C083153:pterosupin; C083154:marsupsin; D002784:Cholesterol; C083152:liquiritigenin