[The participation of neuropeptide Y and the catecholaminergic systems of the brain in feeding behavior].
Following intracerebroventricular (icv) administration of the lowest doses (100 ng) of neuropeptide Y (NPY) the feeding behaviour was suppressed, while higher doses (5 mcg) of NPY enhanced it. Prazosin (9.5 nmol, icv), a selective alpha 1-adrenoceptor antagonist, attenuated the stimulatory effect of 5 mcg NPY on food intake. Yohimbine (15 nmol, icv) and propranolol (5 mg/kg, ip) had no effect on NPY-induced feeding behaviour. Naloxone inhibited NPY-induced feeding behaviour and did not influence on the NPY-induced suppression of food intake. These data give evidence for heterogeneity among the central NPY receptors. The effect of NPY on feeding behaviour may, at least in part, be mediated via alpha 1-adrenoceptors.
Borisova
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Kádár
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D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D009270:Naloxone / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D017983:Receptors, Catecholamine; D015016:Yohimbine / Q000494:pharmacology
D009478:Neuropeptide Y; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D015016:Yohimbine; D009270:Naloxone; D011433:Propranolol; D011224:Prazosin