[Quantitative assessment of lipiodol delivered intra-arterially into hepatoma: with evaluation of MR signal intensity].
We performed an experimental study using a CT phantom with various concentrations of Lipiodol emulsion. On the basis of these experimental data, we performed a quantitative analysis of Lipiodol delivered intra-arterially into hepatomas in order to evaluate the effect of Lipiodol accumulation on the MR signal intensities of hepatomas. The Lipiodol concentration and CT value showed an excellent linear correlation in the phantom study (r = 0.99). Lipiodol was estimated from 0.08 to 2.92 ml (8 to 77% of the injected dose) in hepatomas treated with Lipiodol-TAE. In the MR phantom study, signal intensities showed no remarkable change in cases of low concentrations of Lipiodol emulsion, while they decreased with increased Lipiodol concentrations both for T 1-and T 2-weighted SE and FLASH sequences in cases of high concentrations of Lipiodol emulsion. In the clinical materials, the signal intensities of tumors after Lipiodol-TAE tended not to show any apparent change in tumors with low estimated Lipiodol concentrations, but tended to decrease on all pulse sequences in tumors with high estimated Lipiodol concentrations. CT was useful for the quantitative analysis of Lipiodol accumulation in the tumor. Experimentally and clinically, a low concentration of Lipiodol had no apparent influence on MR signal intensities, while a high concentration tended to decrease signal intensities on all pulse sequences.
Department of Radiology, Kumamoto University, School of Medicine.
M
M
Harada
Y
Y
Yamashita
H
H
Yamamoto
S
S
Yoshimatsu
Y
Y
Sakamoto
M
M
Takahashi
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage; D004655:Emulsions; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008961:Models, Structural
D004655:Emulsions; D007459:Iodized Oil; D002945:Cisplatin