Is paraoxonase related to atherosclerosis.
Human serum paraoxonase is responsible for the hydrolysis of organophosphate anticholinesterases, however, whether the enzyme has a physiological role other than the detoxication of insecticides and nerve gases has remained uncertain. Recently, evidence has begun to accumulate of a relationship between the serum activity of paraoxonase and atherosclerosis. Paraoxonase may a fundamental role in lipoprotein metabolism, preventing oxidative changes to low-density lipoprotein which render the particle atherogenic.
University of Manchester, Department of Medicine, Manchester Royal Infirmary, UK.
M I
MI
Mackness
S
S
Arrol
C A
CA
Abbott
P N
PN
Durrington
D001161:Arteriosclerosis / Q000201:enzymology*; D043303:Aryldialkylphosphatase; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D010744:Phosphoric Monoester Hydrolases / Q000097:blood*
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase