[The effects of angiotensin II and other vasoactive agents on the blood flow in Yoshida ascites hepatoma].
The effects of angiotensin II and other six vasoactive agents on tissue blood flow of Yoshida rat ascites hepatoma AH109A and normal liver were measured by the hydrogen clearance method. The mean blood flow in the tumor peripheral part under normotensin was 11.9 +/- 8.2 ml/min/100 g tissue and was not influenced by tumor size. Tumor blood flow was more significantly increased in infusion angiotensin II than 0.5 mg/ml methoxamine; however, normal liver blood flow of tumor-bearing rats was unchanged in contrast to an increase seen in the tumor. A Pronounced reduction of tumor blood flow was found after administration of epinephrine, norepinephrine and ethylphenylephrine. In addition, metaraminol, phenylephrine as well as 1.0 and 2.5 mg/ml methoxamine were not found to significantly change the blood flow of the tumor.
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Department of Pathology, Norman Bethune University of Medical Sciences, Changchun.
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Zhang
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D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000503:physiopathology*; D008297:Male; D009368:Neoplasm Transplantation; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*
D013566:Sympathomimetics; D000804:Angiotensin II; D009638:Norepinephrine; D004837:Epinephrine