Chemotherapy and combined modality advances in children.
The sustained improvements in pediatric cancer therapy are partially due to the large randomized and nonrandomized studies being conducted by multidisciplinary cooperative groups. Theoretic concepts of chemotherapy are better knowledge of the pharmacokinetics, pharmacodynamics, and drug resistance of current and new drugs are enabling a more rational approach to multiagent therapy. Biologic modifiers are adding to our current multimodal therapeutic approach.
Division of Hematology and Oncology, University of British Columbia, Vancouver, Canada.
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Rogers
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Karabus
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D002648:Child; D003131:Combined Modality Therapy; D004351:Drug Resistance; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy; D008113:Liver Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000628:therapy; D009396:Wilms Tumor / Q000188:drug therapy
D000970:Antineoplastic Agents