Squalane as a possible carrier of bone morphogenetic protein.
Gelatin capsules containing squalane partially purified bone morphogenetic protein (BMP) complex were placed on the perimuscular membrane of rats. Two kinds of control, gelatin capsules containing only BMP and those bearing squalane only, were used. The embedded areas were histopathologically examined at 3 and 6 wk after the operation. The observations revealed that the squalane/BMP complex elicited wide heterotopic bone formation with bone marrow tissue, suggesting that squalane is a possible carrier of BMP for clinical applications.
Department of Oral Pathology, Matsumoto Dental College, Nagano, Japan.
T
T
Kawakami
H
H
Uji
M
M
Antoh
H
H
Hasegawa
T
T
Kise
S
S
Eda
D000818:Animals; D019485:Bone Morphogenetic Proteins; D002214:Capsules; D002417:Cattle; D004337:Drug Carriers; D005260:Female; D006133:Growth Substances / Q000008:administration & dosage; D011506:Proteins / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013185:Squalene / Q000008:administration & dosage / Q000031:analogs & derivatives*
D019485:Bone Morphogenetic Proteins; D002214:Capsules; D004337:Drug Carriers; D006133:Growth Substances; D011506:Proteins; D013185:Squalene; C019556:squalane