Detection of Epstein-Barr virus DNA in cardiac and aortic tissues from chronic, active Epstein-Barr virus infection associated with Kawasaki disease-like coronary artery aneurysms.
We describe three patients with chronic, active Epstein-Barr virus infection associated with Kawasaki disease-like coronary artery aneurysms. The Epstein-Barr virus genome was detected in three cardiac tissue samples and one aortic tissue sample examined by means of the polymerase chain reaction. These findings suggest that chronic Epstein-Barr virus infection may play a pathogenic role in the development of coronary artery aneurysms.
Kikuta
H
H
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Sakiyama
Y
Y
Matsumoto
S
S
Hamada
I
I
Yazaki
M
M
Iwaki
T
T
Nakano
M
M
D000914:Antibodies, Viral / Q000097:blood; D001011:Aorta / Q000737:chemistry*; D015139:Blotting, Southern; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003323:Coronary Aneurysm / Q000175:diagnosis* / Q000209:etiology; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications / Q000175:diagnosis*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000175:diagnosis*; D009206:Myocardium / Q000737:chemistry*; D016133:Polymerase Chain Reaction
D000914:Antibodies, Viral; D004279:DNA, Viral