Unusual deficiency of the modified purine base queuine in transfer ribonucleic acid from the human placenta as tested by enzymatic assay.
Transfer ribonucleic acid from rapidly growing tissues, particularly from neoplasia, is partially deficient in queuine, a highly modified transfer ribonucleic acid constituent. By means of an enzymatic assay we also found a queuine deficiency (14%) in human placenta transfer ribonucleic acid despite its high concentrations in the amniotic fluid. Proposed cause and significance of the results are discussed.
Baranowski
W
W
Second Clinic of Gynecological Surgery, Academy of Medicine, Lublin, Poland.
Tomaszewski
J
J
Keith
G
G
D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D012343:RNA, Transfer / Q000737:chemistry*
D006147:Guanine; C019549:queuine; D012343:RNA, Transfer