From proopiomelanocortin to cancer. Possible role of convertases in neoplasia.
Melanophore-stimulating hormones (MSHs) are produced from a common precursor called proopiomelanocortin (POMC). These peptides have been at the center of studies on the prohormone theory since 1967. The recent discovery of endoproteases which can convert POMC to MSHs is having more biological implications than previously imagined, most particularly for proliferative diseases like cancer.
Mbikay
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Laboratory J.A. de Sève de Neuroendocrinologie Moléculaire, Université de Montréal, Québec, Canada.
Seidah
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Chretien
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D000595:Amino Acid Sequence; D010450:Endopeptidases / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000096:biosynthesis / Q000502:physiology*; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000209:etiology / Q000503:physiopathology*; D011333:Pro-Opiomelanocortin / Q000378:metabolism*; D043484:Proprotein Convertases; D011498:Protein Precursors / Q000378:metabolism; D013379:Substrate Specificity
D006133:Growth Substances; D006728:Hormones; D011498:Protein Precursors; D011333:Pro-Opiomelanocortin; D009074:Melanocyte-Stimulating Hormones; D010450:Endopeptidases; D043484:Proprotein Convertases