Functional changes associated with experimentally induced endolymphatic hydrops.
A guinea pig model with surgically induced endolymphatic hydrops of the inner ear has been developed and studied over the past thirty years. The aim of such studies is to obtain insight into physiological processes associated with endolymphatic hydrops in man and in particular in Menière's disease where endolymphatic hydrops is systematically encountered at post-mortem examination of the temporal bones. The present review attempts to draw together the data pertaining to functional modifications of inner ear function in the animal model. For simplicity the data are categorised under five main titles: electrochemical modifications, electrophysiological modifications, pressure and hydrops, sensitivity to other insults and vestibular dysfunction. One of the most striking observations that can be made is that the data originating from different authors are very variable. There is, however, some evidence suggesting that the evolution of the auditory dysfunction could be considered as consisting of a series of different phases. This kind of information could serve as a basic framework for future research on the animal model.
Inserm U229, Laboratoire d'Audiologie Expérimentale, Hôpital Pellegrin, Bordeaux, France.
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Horner
D000617:Aminoglycosides / Q000633:toxicity; D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000503:physiopathology*; D004195:Disease Models, Animal; D004232:Diuretics / Q000633:toxicity; D004487:Edema / Q000503:physiopathology*; D004594:Electrophysiology; D004710:Endolymph / Q000502:physiology*; D006168:Guinea Pigs; D006801:Humans; D008575:Meniere Disease / Q000503:physiopathology*; D015837:Vestibular Diseases / Q000503:physiopathology
D000617:Aminoglycosides; D004232:Diuretics