Cu-Zn superoxide dismutase activities in platelets from stable bronchial asthmatic patients.
Cu-Zn superoxide dismutase (SOD) activities in platelets from stable bronchial asthmatic patients were measured using 2-methyl-6-[p-methoxyphenyl]-3,7- dihydroimidazo[1,2-a]pyrazin-3-one as a chemiluminescence probe. Cu-Zn SOD activities in platelets from the asthmatics were significantly higher than those from normal healthy subjects. Platelet Cu-Zn SOD activities were significantly higher in atopic than in non-atopic asthmatics. There were no significant differences in platelet Cu-Zn SOD activities between aspirin-sensitive and aspirin-tolerant patients. These results suggest that an oxidant-to-antioxidant imbalance may play a role in the inflammatory situations in the airways of asthmatics.
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
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M
Kurosawa
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Kobayashi
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M
Nakano
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000494:pharmacology; D001249:Asthma / Q000097:blood / Q000201:enzymology* / Q000209:etiology; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*; D013481:Superoxides / Q000097:blood
D013481:Superoxides; D013482:Superoxide Dismutase; D001241:Aspirin