Antiherpes effect of Melissa officinalis L. extracts.
Studies were carried out on the virucidal and antiviral effects of Melissa officinalis L. extracts (M1, M3, M3 and M4) with respect to Herpes simplex virus type 1 (HSV-1). Virucidal effect was registered within 3 and 6 hours of treatment using M4 administered in MTC. The remaining extracts inactivate the virus at the 12th and 24th hour. No significant values of inhibiting activity of M1, M2, and M3 on the same virus in vitro or in vivo were demonstrated. The presence of caffeic, rosmarinic and ferulic acids was demonstrated by thin-layer chromatography. Their role in the antiviral activity of M. officinalis L. is discussed.
Dimitrova
Z
Z
Centre of Biogenic Stimulants, Sofia.
Dimov
B
B
Manolova
N
N
Pancheva
S
S
Ilieva
D
D
Shishkov
S
S
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002855:Chromatography, Thin Layer; D004353:Drug Evaluation, Preclinical; D005260:Female; D016849:Keratitis, Herpetic / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D008297:Male; D010936:Plant Extracts / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors; D014776:Virus Cultivation
D000914:Antibodies, Viral; D000998:Antiviral Agents; D010936:Plant Extracts