Neuroendocrine and temperature effects of nefazodone in healthy volunteers.
The effects of a novel antidepressant, nefazodone (50 mg, 100 mg, and 200 mg orally) on neuroendocrine function and temperature were assessed using a single-blind, crossover design in eight healthy male volunteers. Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated through nefazodone's metabolism to its major metabolite, m-chlorophenylpiperazine (mCPP).
MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.
A E
AE
Walsh
R A
RA
Hockney
G
G
Campling
P J
PJ
Cowen
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010879:Piperazines; D010919:Placebos; D011388:Prolactin / Q000097:blood*; D016037:Single-Blind Method; D014230:Triazoles / Q000494:pharmacology*
D000928:Antidepressive Agents; D010879:Piperazines; D010919:Placebos; D014230:Triazoles; C051752:nefazodone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D006854:Hydrocortisone