Nucleotide sequence comparison of the VP8* gene of rotaviruses possessing the AU-1 gene 4 allele.
Of the five currently recognized alleles of the human rotavirus VP4 gene, the AU-1 allele has captured attention because of its possible non-human origin. The 5' 750 nucleotide region of the VP4 gene, encoding the VP8* fragment [amino acids (aa) 1 to 241] and the connecting peptide (aa 242 to 247), from 13 human and two feline rotavirus strains possessing the AU-1 allele was highly conserved both at the nucleotide sequence (93.8 to 99.7% identity) and amino acid level (95.5 to 100% identity) irrespective of the year and the place of isolation or of the host species from which these viruses were isolated. This is consistent with the hypothesis that the AU-1 allele of the VP4 gene has been maintained in both human and feline rotavirus gene pools.
Department of Microbiology, Akita University School of Medicine, Japan.
O
O
Nakagomi
Y
Y
Isegawa
S
S
Ueda
G
G
Gerna
A
A
Sarasini
E
E
Kaga
T
T
Nakagomi
J
J
Flores
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D002415:Cats; D017124:Conserved Sequence / Q000235:genetics; D005814:Genes, Viral / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012401:Rotavirus / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D036022:Capsid Proteins; C060339:VP4 protein, Rotavirus