[The effect of high-altitude ecological and experimental stresses on the thrombocyte-vascular wall system].
Experiments in animals (rats) and examinations of the population of high-altitude shepherds were used to study the functional system "Thrombocytes-Vessel Wall" (STVW) for evaluation of the organism ecological adaptation to "pure" high-altitude stress, with and without combination with experimental-adrenergic cardionecrosogenic stress (ACNS, in rats). The adaptive increase of antiaggregation prostacyclin activity of the aorta in rats and PGI2 reaction of vessels in human population of high-altitude in mountains (2000, 3000-3500 m) were found to be a common biologist regularity. The adaptive increase of coronary reserve of the heart and vasodilatator-antiaggregation status in high-altitude shepherds correlated with an increase of antiaggregation activity of the aorta and decrease of spontaneous aggregation of the thrombocytes in rats under conditions of more prolonged adaptation to high-altitude ecological stress.
A K
AK
Bekbolotova
V A
VA
Lemeshenko
M A
MA
Aliev
D000222:Adaptation, Physiological; D000328:Adult; D000531:Altitude; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001808:Blood Vessels / Q000502:physiology*; D004463:Ecology; D005260:Female; D006801:Humans; D007707:Kyrgyzstan; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D051381:Rats; D012917:Social Adjustment; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors