Enhancement of BM allografting from C57BL/6 'nude' mice into C3H/HeJ recipients by tolerized T cells from (C57BL/6-->C3H/HeJ) and (C3H/HeJ-->C57BL/6) chimeras.
The possible participation of T cells in the promotion of hematopoietic engraftment of BM allografts, as opposed to their potential role in overcoming host-versus-graft reactions, was investigated recently by using (host x donor)F1 T cells devoid of graft-versus-host activity. In the present study, we provide further evidence of this effect by using tolerized thymocytes from established allogeneic chimeras. We show that tolerant mature thymocytes from donor type (C57BL/6-->C3H/HeJ) or host type (C3H/HeJ-->C57BL/6) chimeras are as effective as (donor x host)F1 thymocytes in promoting both short-term and long-term engraftment of C57BL/6-Nu/Nu T cell-depleted BM cells in lethally irradiated C3H/HeJ recipients.
Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.
Y
Y
Faktorowich
T
T
Lapidot
I
I
Lubin
Y
Y
Reisner
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005260:Female; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D007108:Immune Tolerance; D037102:Lectins; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D019887:Peanut Agglutinin; D011828:Radiation Chimera / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D037102:Lectins; D019887:Peanut Agglutinin