[The role of intraglomerular hypertension and lipids in the development of diabetic nephropathy].
To determine the mechanisms underlying diabetic nephropathy (DN) onset, a clinical and morphological study was initiated of 14 diabetics with insulin-dependent disease free of clinical renal manifestations. The patients were examined for intraglomerular hypertension, blood lipid spectrum and renal tissue morphology. In high intraglomerular hypertension, i. e. in renal functional reserve depletion, there is dyslipidemia with a characteristic significant rise in the levels of very low density lipoprotein cholesterol and low density lipoprotein cholesterol, in the value of atherogenic index. Morphologically, renal tissue of the hypertensive and dyslipidemic patients experienced hyperperfusion and massive lipid infiltration in glomerular cells. In contrast, renal tissue underwent only minimal nonspecific changes when intraglomerular hemodynamics and lipidemia were normal. The findings suggest that associated effects of intraglomerular hypertension and dyslipidemia may promote DN onset.
Shestakova
M V
MV
Neverov
N I
NI
Dedov
I I
II
D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications*; D006977:Hypertension, Renal / Q000097:blood / Q000150:complications*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
D008055:Lipids