[The sodium oxybutyrate and nooglutil correction of dopamine release in the striatum of prenatally alcoholized rat pups].
The influence of prenatal exposure to ethanol on endogenous Dopamine (DA) release from perfused isolated striata of 20-day-old rats was studied, as well as its correction by nootropic drugs: sodium hydroxy butyrate and nooglutil. Administration of 20% ethanol per os at a daily dose of 5 mg per kg during the entire period of pregnancy led to a significant decrease in basal and K(+)-evoked DA efflux. Hydroxy-butyrate and Nooglutil (50 and 25 mg per kg, subcutaneously, daily from the 8th to the 20th day of life) normalized these alterations in alcohol-exposed neonates, although their effects on the offsprings of non-alcoholized rats were opposite. The probable neurochemical targets of ethanol and nootropics are discussed.
Kovalev
G I
GI
Budygin
E A
EA
Gaĭnetdinov
R R
RR
Kudrin
V S
VS
Trofimov
S S
SS
Ostrovskaia
R U
RU
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012978:Sodium Oxybate / Q000494:pharmacology*
D005971:Glutamates; D009539:Nicotinic Acids; D011619:Psychotropic Drugs; C066295:nooglutil; D015102:3,4-Dihydroxyphenylacetic Acid; D000431:Ethanol; D012978:Sodium Oxybate; D004298:Dopamine