Clinical spectrum of neurological herpes simplex infection.
All cases of neurological infections virologically verified as due to herpes simplex virus (HSV) during a 2-year period in the Helsinki University Hospital area were studied. Altogether 10 cases were divided clinically into two forms: encephalitis 5 cases, polyradiculomyelitis, meningitis and miscellaneous 5 cases. All the cases of encephalitis were treated with acyclovir. None of the severe cases of herpes radiculomyelitis received this drug, because of lack of a rapid virological diagnosis. Besides encephalitis HSV was associated with other types of severe diseases and those need attention for proper therapy.
Department of Neurology, University of Helsinki, Finland.
M
M
Färkkilä
M
M
Koskiniemi
A
A
Vaheri
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008875:Middle Aged; D009187:Myelitis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D011128:Polyradiculopathy / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D018139:Simplexvirus / Q000302:isolation & purification
D000212:Acyclovir