[A quantitative tissue analysis of the rat myocardium in whole-body overheating].
The reorganization of Wistar rat myocardium at 3 and 7 days after a single total overheating at a temperature of 43 degrees C was studied using stereologic and qualitative morphological tissue analysis. Most pronounced morphofunctional changes in myocardium were shown to develop 3 days after the exposure such as hemodynamic disorders, lymphostasis, interstitial edema, contracture lesions of cardiomyocytes. The spatial myocardial reorganization was not considerable. At 7 day after exposure, a significant decrease of the heart weight as a result of atrophic changes in cardiomyocytes was recorded. In the same period the most pronounced spatial reorganization of myocardial parenchyma and stroma was noted. The significant decrease of volume density of capillaries was accompanied by some increase of the volume density of cardiomyocytes resulting in a significant decrease of volume ratio of capillaries to cardiomyocytes. Thus, during postheating restitution the atrophy of myocardium developed characterized by an unbalanced decrease of volume densities of capillaries and cardiomyocytes.
E L
EL
Lushnikova
L M
LM
Nepomniashchikh
M G
MG
Klinnikova
O P
OP
Molodykh
D000818:Animals; D001835:Body Weight; D005334:Fever / Q000473:pathology*; D006652:Histological Techniques; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors