[Complications of immunosuppression].
In the near future several new immunosuppressive substances will be available: Cyclosporin G, IMM125 (both are new derivates of Cyclosporin A), FK506, Rapamycin, Leflunomid, Mycophenolic acid (RS-61443), Bredinin (Mizorinin), Brequinar, Deoxyspergualin and several new monoclonal antibodies (anti-CD4, anti-II-2-Receptor, anti-CD8, anti-CD45, anti-ICAM1 and others). Side-effects of immunosuppressants are classified in 1) relative drug-specific or 2) unspecific effects of over-immunosuppression (infections and malignancies). Nephrotoxicity of Cyclosporin A and guidelines for its prevention are covered in more detail. The authors fear, that the proliferation of new immunosuppressive drugs will make it more difficult, to carefully evaluate their side-effects.
Kantonsspital Basel, Department Innere Medizin, Abt. Nephrologie.
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G
Thiel
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Bock
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Landmann
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Mihatsch
D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine