Image cytometry of hepatocellular carcinoma: comparison with alcoholic cirrhosis and normal liver.
Image cytometry can provide valuable information for the prognosis of patients with malignant tumours. This study was performed on three cell populations: hepatocellular carcinoma (n = 30), alcoholic cirrhosis (n = 12) and normal liver (n = 2). The results showed that hepatocellular carcinoma cell populations contained more hyperploid and aneuploid cells than cirrhosis and normal liver cell populations; two groups of hepatocellular carcinoma were separated, called A and B. The values of group A cytometric parameters were close to those of cirrhosis whereas group B nuclei had a much higher DNA content and were more often hyperploid or aneuploid. These two groups were also different according to biological (alpha-foetoprotein) or clinical (survival time) variables. Since group A seemed to be made up of patients with better prognosis than group B, cytometric analysis of hepatocellular carcinoma could be a tool for prognosis and clinical management of patients with hepatocellular carcinoma.
Service de Gastroentérologie et d'Hépatologie, CHU A. Michallon, Grenoble, France.
V
V
Li
J P
JP
Zarski
D
D
Seigneurin
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000166:cytology*; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values