[A comparative study of the reinforcing and analgesic properties of cocaine].
During comparative studies of analgesic (writhing test) and reinforcing (place preference test) effects of cocaine, 5-40 mg/kg), the neurochemical dissociation of the effects of cocaine was found. Haloperidol, (0.06-1.0 mg/kg) inhibited cocaine-induced analgesia in a dose-dependent manner, but failed to influence cocaine-induced reinforcement. On the contrary, naloxone (0.25-1.0 mg/kg) inhibited cocaine-induced reinforcement, unaffecting drug-induced analgesia. The roles of opiatergic and dopaminergic systems in producing effects of cocaine are discussed.
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Kuz'min
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Zvartau
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D012054:Reinforcement, Psychology; D013035:Spasm / Q000139:chemically induced / Q000503:physiopathology
D000700:Analgesics; D011957:Receptors, Opioid; D009270:Naloxone; D003042:Cocaine; D006220:Haloperidol