Apolipoprotein E polymorphism modifies relation of hyperinsulinemia to hypertriglyceridemia.
The effect of apolipoprotein E polymorphism on the established relationships between glucose tolerance, plasma insulin levels, and plasma lipoprotein concentrations were investigated in a sample of women defined on the basis of apolipoprotein E phenotypes. In women with the apolipoprotein E epsilon 2 allele (n = 22), fasting plasma insulin and glucose and insulin areas under the curve measured during an oral glucose tolerance test were positively correlated with plasma triglyceride levels (0.48 < or = r < or = 0.70; P < 0.05). In this group, very-low-density lipoprotein cholesterol and very-low-density lipoprotein triglyceride concentrations were positively correlated with fasting insulin levels, the insulin area, and with the ratio of insulin area to glucose area. In women (n = 24) homozygous for the apolipoprotein E epsilon 3 allele (the most common allele), essentially similar associations were found. In contrast, in women (n = 17) with the apolipoprotein E epsilon 4 allele, no association was found between glucose tolerance, fasting and postglucose plasma insulin levels, and plasma lipid and lipoprotein levels. These results suggest that apolipoprotein E polymorphism substantially modifies the associations between glucose tolerance, plasma insulin levels, and plasma lipoprotein concentrations. Additional analysis of the data revealed that apolipoprotein E polymorphism did not alter the relationships between body fat distribution and fasting insulin and postglucose insulin levels, but no correlation was observed between fatness indexes and glucose tolerance among apolipoprotein E epsilon 2 carriers.(ABSTRACT TRUNCATED AT 250 WORDS)
Després
J P
JP
Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada.
Verdon
M F
MF
Moorjani
S
S
Pouliot
M C
MC
Nadeau
A
A
Bouchard
C
C
Tremblay
A
A
Lupien
P J
PJ
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000737:chemistry; D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D005215:Fasting / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D015228:Hypertriglyceridemia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008055:Lipids / Q000032:analysis; D008074:Lipoproteins / Q000097:blood; D010641:Phenotype; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D005947:Glucose