The influence of 1'-methyl- and 1'-ethylascorbigen on metabolism of arachidonic acid in murine spleen cells.
Ascorbigens are indole-containing derivatives of L-ascorbic acid, some of them (e.g., 1'-methylascorbigen) have been shown to inhibit growth of experimental murine tumors. Immunomodulating properties of 1'-methylascorbigen correlated with its antitumor effect. The immunomodulating action of 1'-methylascorbigen is to a marked degree based on its influence on arachidonic acid metabolism in murine spleen cells. A single injection of 50 mg/kg 1'-methylascorbigen leads to pronounced and immediate increase of the cells' ability to produce PGE2 and LTB4 (up to 550% and 460%, correspondingly). Till the tenth day after injection the levels of these metabolites of arachidonic acid were double that of the control.
Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
S
S
Efimov
V
V
Shevchenko
I
I
Shchukin
M
M
Preobrazhenskaya
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D002478:Cells, Cultured; D015232:Dinoprostone / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D007975:Leukotriene B4 / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000378:metabolism
D007211:Indoles; C079773:1'-ethylascorbigen; D007975:Leukotriene B4; D016718:Arachidonic Acid; D000001:Calcimycin; C074796:1'-methylascorbigen; D015232:Dinoprostone; D001205:Ascorbic Acid; D002118:Calcium