Decrease in the placental transfer of chloramphenicol when administered in albumin microspheres into rats.
Chloramphenicol is an antibiotic which can pass across the human placenta and has teratogenic effects in the foetus. When this antibiotic is entrapped in albumin microspheres and administered to pregnant rats intravenously its placental transport is significantly lowered when compared with that of free drug. Drug modifications such as entrapment are suggested as an alternative way to prevent harmful effects of drugs in case of consumption during pregnancy.
Hacettepe University, Department of Biology, Beytepe, Ankara, Turkey.
M A
MA
Onur
I
I
Vural
H S
HS
Kaş
A A
AA
Hincal
T
T
Coşkun
G
G
Kanra
A
A
Tümer
D000818:Animals; D002250:Carbon Radioisotopes; D002701:Chloramphenicol / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D008431:Maternal-Fetal Exchange; D008863:Microspheres; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D012709:Serum Albumin / Q000008:administration & dosage / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D012709:Serum Albumin; D002701:Chloramphenicol