[Syndrome "X"].
Already in 1988 Raeven mentioned a syndrome of resistance to insulin (X-syndrome). Before and after that description, several studies featured the central role of tissue resistance to the effects of endogenous insulin during development of diverse biological disturbances: adipositas, intolerance to glucose (or diabetes mellitus), arterial hypertension, dyslipidemia, atherosclerosis. The author summarizes the available literature on this 'new' syndrome that has hitherto not yet been accepted by all scientists. However, although data so far do not always coincide, many recent results give evidence for the importance of the role of a fateful span: resistance to insulin (probably of genetic origin) and secondary hyperinsulinemia. Their role in the genesis of the above-mentioned clinical disturbances is described, as measures for 'physiological' therapy are stressed: strict diet and regular physical exercises. If these simple measures fail, special drugs may be effective.
FMH en endocrinologie, anc. méd. adj. au CHUV, Lausanne.
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Chabot
D001161:Arteriosclerosis / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood; D006949:Hyperlipidemias / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000378:metabolism*; D013577:Syndrome
D001786:Blood Glucose