Effect of intragastric and intravenous ethanol on food intake in rats.
The effects of a continuous intragastric (via a gastrostomy) and intravenous (via an indwelling jugular catheter) infusion of 3% ethanol at 3 ml/h on food intake was examined in rats randomly assigned to a two period crossover study. The 3% ethanol solution provided 19 kcal/day, which was equivalent to about 50% of the daily caloric intake of the rats. Ethanol significantly decreased food intake irrespective of the route administered. But, reduction in food intake did not result in a calorie-to-calorie compensation. Instead, providing 50% of calories as 3% ethanol via the intragastric route led to a 16% reduction in food intake, while only a 9% reduction in food intake occurred when the 3% ethanol solution was given intravenously.
Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse 13210.
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Giner
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Meguid
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D004750:Enteral Nutrition; D000431:Ethanol / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D000431:Ethanol