Distribution and effect of iodized poppyseed oil in the liver after hepatic artery embolization: experimental study in several animal species.
To define the intrahepatic distribution of iodized poppyseed oil and its effect on the liver, hepatic artery embolization (HAE) was performed in five mice, 12 rats, four rabbits, and 21 pigs with the iodized oil alone or in combination with gelatin sponge powder (GSPow) in three rats or gelatin sponge particles (GSPs) in nine pigs. All mice, rats, and rabbits underwent radiography of the upper abdomen and in vivo microscopy of the hepatic periphery during and immediately after injection and 1, 4, and 24 hours later. All pigs underwent angiography before and after HAE as well as measurement of portal venous pressure before HAE and 15, 30, 45, and 60 minutes and 4 weeks after HAE. Follow-up radiographs were obtained in 18 pigs. HAE performed with the iodized oil only was well tolerated by the liver, even when high doses were used, likely because of continuous flushing of the sinusoids by high blood flow from peripheral arterioles. When HAE was performed with the iodized oil and GSPow, this blood flow ceased and necrosis developed. The degree of necrosis after HAE with the iodized oil in combination with GSPs was directly associated with the dose of iodized oil. HAE performed with GSPs only did not cause damage.
Department of Diagnostic Radiology, University of Lund, Malmö General Hospital, Sweden.
Z
Z
Kan
M
M
Sato
K
K
Ivancev
B
B
Uchida
P
P
Hedgpeth
A
A
Lunderquist
J
J
Rosch
R
R
Yamada
D000818:Animals; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects; D005781:Gelatin Sponge, Absorbable; D006499:Hepatic Artery; D007459:Iodized Oil / Q000009:adverse effects / Q000493:pharmacokinetics*; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008102:Liver Circulation / Q000502:physiology; D051379:Mice; D008811:Mice, Inbred DBA; D011208:Powders; D011817:Rabbits; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley; D013552:Swine; D014018:Tissue Distribution
D011208:Powders; D007459:Iodized Oil