Participation of complement in nasal polyposis.
No changes in immunoglobulin (IgG, IgM and IgA) and complement components C3 and C4 levels could be observed in patients suffering from both recurrent and acute nasal polyposis. However, in both groups of patients a significant decrease of the alternative pathway of complement activation (up to 80%) was found. In addition, patients suffering from the acute disease showed even decreased classical complement pathway (up to 20%). Examination of complement activation pathways was shown to be advantageous for the follow-up of the course of this disease.
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.
J
J
Zídková
V
V
Stĕdrý
V
V
Zídek
I
I
Volfová
O
O
Síbl
D000208:Acute Disease; D000328:Adult; D000368:Aged; D003176:Complement C3 / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D003170:Complement Pathway, Alternative; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000097:blood / Q000276:immunology*; D012008:Recurrence
D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins