Tissue-specific isoforms of the bovine mitochondrial ATP synthase gamma-subunit.
Tissue-specific isoforms of the gamma-subunit of the bovine FoF1-ATP synthase were identified for the first time. The two isoforms, heart and liver type, were generated by alternative splicing, the liver-type RNA transcript containing a 37-nucleotide sequence as a cassette exon. Protein sequencing of the C-terminal fragments of the two isoforms of the F1 gamma-subunit indicated that the liver-type isoform had an additional aspartate residue at the C terminus, not present in the heart type one.
Department of Biochemistry, Jichi Medical School, Tochigi, Japan.
C
C
Matsuda
H
H
Endo
H
H
Hirata
H
H
Morosawa
M
M
Nakanishi
Y
Y
Kagawa
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004272:DNA, Mitochondrial; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism; D008929:Mitochondria, Heart / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D008969:Molecular Sequence Data; D009928:Organ Specificity; D006180:Proton-Translocating ATPases / Q000235:genetics* / Q000378:metabolism
D004272:DNA, Mitochondrial; D007527:Isoenzymes; D006180:Proton-Translocating ATPases