The influences of fragments and analogs of ACTH/MSH upon recovery from nervous system injury.
Post-injury treatment with some fragments and analogs of the adrenocorticotropic hormone (ACTH) can influence recovery after nervous system injury. This review considers both the successful and unsuccessful attempts to facilitate neural and behavioral recovery from nervous system damage via post-injury administration of these compounds. To date no single unifying explanation for the mixed results observed in animals prepared with forebrain injuries has been achieved. Several possible explanations for the variety of observations reported and several potentially productive avenues for future research are suggested.
Department of Psychology, Georgia College, Milledgeville 31061.
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WF
McDaniel
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000595:Amino Acid Sequence; D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000627:therapeutic use*
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones