[Opiate reception in the rat brain: the effect of chronic consumption of alcohol and reaferon].
Binding properties of opiate receptors were studied in brain tissue of alcoholized rats after administration of the interferon-derived drug reaferon using equilibrium radioreceptor assay. Chronic alcohol intoxication was accompanied by a decrease in affinity of opiate mu-receptors for ligands in the animals with alcohol intoxication and ethanol withdrawal. Alterations in parameters of delta-reception and in content of mu-receptors were not found. Daily administration of reaferon at a dose of 10(4) U within 1.5 month did not affect these impairments, observed in rats, studied in intoxication. However, the drug reduced completely the alcohol effect on receptors during the withdrawal period. Possible normalizing effects of reaferon on the state of opiate receptors are discussed.
A M
AM
Balashov
O B
OB
Petrichenko
T N
TN
Aliab'eva
L F
LF
Panchenko
D000428:Alcohol Drinking; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D016308:Enkephalin, Leucine-2-Alanine / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008297:Male; D009270:Naloxone / Q000378:metabolism; D051381:Rats; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000378:metabolism*; D017450:Receptors, Opioid, mu / Q000187:drug effects / Q000378:metabolism*; D011994:Recombinant Proteins
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D011994:Recombinant Proteins; D009270:Naloxone; D000431:Ethanol; D016308:Enkephalin, Leucine-2-Alanine