cDNA cloning and sequence analysis of the human A3 adenosine receptor.
We report the cloning of the cDNA encoding the homolog of the A3 adenosine receptor (A3AR) from a human heart library. The receptor shares a surprisingly low degree of sequence homology to the rat A3AR. Northern analysis of various human tissues showed the human A3AR gene to be expressed primarily in lung, liver, kidney and heart, with very little expression in the brain or in skeletal muscle.
Gensia Inc., San Diego, CA 92121-1204.
F G
FG
Sajjadi
G S
GS
Firestein
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry / Q000235:genetics; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011983:Receptors, Purinergic / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D011983:Receptors, Purinergic; D004247:DNA