Neuron-specific enolase: a serum tumor marker in malignant germ-cell tumors?
Neuron-specific enolase was determined in 100 patients with germ-cell tumors. An elevation was found in 5/18 patients with advanced seminoma and in 7/25 patients with advanced nonseminoma. Including all tumor stages of both seminoma and nonseminoma, we found less than 20% NSE-positive patients. Some of these showed false-positive or false-negative results during follow-up examinations. NSE does not seem to be a valuable tumor marker in germ-cell tumors.
Gross
A J
AJ
Urologische Klinik, Universitätsklinikum Eppendorf, Hamburg, FRG.
Dieckmann
K P
KP
D014408:Biomarkers, Tumor / Q000032:analysis*; D004407:Dysgerminoma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000473:pathology
D014408:Biomarkers, Tumor; D010751:Phosphopyruvate Hydratase