[Arterial embolism and thrombocytopenia during heparin therapy].
This is a case report of heparin-associated thrombocytopenia syndrome (white clot syndrome). An 81-Year-old patient was treated with sodium-heparin for proximal deep-venous thrombosis and pulmonary embolism. During administration of heparin, the platelet count decreased to a nadir of 27/nl on day 14 after initiation of this therapy. We also observed a recurrence of pulmonary embolism as well as arterial thromboembolism in the right arm and the right leg. After immediate discontinuation of heparin therapy and change of anticoagulation to oral anticoagulants with overlapping administration of a low molecular weight heparin and application of immunoglobulins, we observed total recanalization of the arterial occlusions, normalization of lung-perfusion scan and rapid recovery of the platelet count.
Medizinische Poliklinik, Westfälischen Wilhelms-Universität, Münster.
M
M
Hausberg
K
K
Stöber
S
S
Heidenreich
F
F
Koc
W
W
Stenzinger
C
C
Spieker
K H
KH
Rahn
D000368:Aged; D000369:Aged, 80 and over; D006493:Heparin / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000097:blood / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced*; D013923:Thromboembolism / Q000097:blood / Q000188:drug therapy*
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin