[The role of pharmacologic kidney protection in preventing post-ischemic renal failure in animal experiment].
The postischemic acute renal failure is one of the most important and frequent complications after surgery for renal artery and thoracoabdominal aortic diseases. In a canine model we studied the possible beneficial effects of Prostaglandin E1 (PGE1), Diltiazem and Superoxiddismutase (SOD) on postischemic renal function. 46 dogs were exposed to 3 hours ischemia. In 35 dogs PGE1 (n = 10), Diltiazem (n = 10), Superoxiddismutase (n = 10) or both PGE1 and SOD (n = 5) were given intravenously. 11 dogs treated with normal saline served as controls. Glomerular filtration rate, renal plasma flow, plasma creatinine, blood urea nitrogen, urine volume, free water clearance and renovascular resistance were calculated before and after renal ischemia. Radionuclide studies were performed on the third postoperative day. Two weeks later clearance measurements were repeated and kidneys were removed for histology. PGE1, Diltiazem and SOD significantly attenuated the post-ischemic fall in glomerular filtration rate and renal concentrating ability as well as the postischemic changes of tubular epithelium on histology.
Klinik für Gefässchirurgie und Nierentransplantation, Heinrich-Heine-Universität Düsseldorf.
G
G
Torsello
P
P
Reinecke
Z
Z
Szabo
W
W
Sandmann
D058186:Acute Kidney Injury / Q000473:pathology / Q000517:prevention & control*; D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D003404:Creatinine / Q000097:blood; D004110:Diltiazem / Q000494:pharmacology*; D004285:Dogs; D004359:Drug Therapy, Combination; D007511:Ischemia / Q000150:complications* / Q000473:pathology; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007677:Kidney Function Tests; D012079:Renal Circulation / Q000187:drug effects; D013482:Superoxide Dismutase / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
D003404:Creatinine; D013482:Superoxide Dismutase; D004110:Diltiazem; D000527:Alprostadil