[Change and effect of Epstein Barr virus (EBV) antigen induced T8 cells in nasopharyngeal carcinoma patients and EBV seropositive individuals].
T8 cells from peripheral blood mononuclear cells (PBMC) of nasopharyngeal carcinoma (N PC) patients, IgA/VCA positive and negative normal individuals were induced by Epstein Barr virus (EBV) antigen, and their effects on the EBV infected auto-PBMC were observed. The data showed: after PBMC were induced by EBV antigen for 5 days, the T8 cells increased in the all three groups, but less remarkably in NPC group than in the other two groups. The T8 cells induced by EBV antigen could inhibit the activation, proliferation and differentiation of EBV infected auto-B cells in IgA/VCA positive and negative groups. But they had an enhancing effect in NPC group. The results suggest that the production of these cells was reduced and their function altered in NPC patients. Therefore it may be related to the enhancement of EBV activated B cells.
Department of Pathophysiology, Guangdong Medical College, Zhanjang.
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PC
Huang
D000328:Adult; D000956:Antigens, Viral / Q000097:blood / Q000276:immunology*; D001402:B-Lymphocytes / Q000378:metabolism; D002213:Capsid / Q000276:immunology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology
D000956:Antigens, Viral; D007070:Immunoglobulin A