The relationship between collagen metabolism and temporomandibular joint osteoarthrosis in mice.
The histologic changes in the temporo mandibular joint (TMJ) and the activity of serum collagenase-like (CL) peptidase and prolyl endopeptidase (PEP) were compared in mice with spontaneous osteoarthrosis (C57 black mouse/6 Silverberg (C57BL/6S) and control mice (C57 black mouse/6N (C57BL/6N) and ddY). The onset of osteoarthrosis of the TMJ in the C57BL/6S mice was noted at 12 weeks of age. Clefting in the chondrocyte layer was noted at 24 to 36 weeks of age; chondrocyte cluster and pannus at 36 to 60 weeks of age; and clefts deep in the bone and formation of osteophytes at 72 to 96 weeks of age. CL-peptidase and PEP activity significantly higher in C57BL/6S mice than in osteoarthrosis-free C57BL/6N and ddY mice. These changes occurred at an earlier age than the histologic changes. The findings suggest that these enzymes may play a significant role in the onset of osteoarthrosis in joints.
Fukuoka
Y
Y
Department of Oral Surgery, Nagoya University School of Medicine, Aichi, Japan.
Hagihara
M
M
Nagatsu
T
T
Kaneda
T
T
D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D003012:Microbial Collagenase / Q000097:blood; D010003:Osteoarthritis / Q000201:enzymology* / Q000473:pathology; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000097:blood; D013583:Synovial Membrane / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000201:enzymology* / Q000473:pathology; D013997:Time Factors
D003094:Collagen; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; D003012:Microbial Collagenase