Pathology of hepatocellular carcinoma.
This study provides a guideline to a dynamic approach toward the diagnosis of hepatocellular carcinoma (HCC). Bile production, fibrinogen synthesis, Mallory body, fibrinogen ground-glass and abnormal glycogen bodies as a reflection of "clone" selection, and hepatitis B virus (HBV) antigen expression in tumor cells can be considered as markers for the morphological diagnosis of HCC. The demonstration in tumor cells of these diagnostic features requires a careful screening of routinely stained preparations in search of suggestive, characteristic, specific, or pathognomonic features further supplemented by ancillary techniques, such as histochemistry, immunocytochemistry, and electron microscopy.
Department of Pathology, Istituto Giannina Gaslini, Genoa, Italy.
F
F
Callea
M
M
Favret
C
C
Marino
M
M
Brisigotti
D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002999:Clone Cells / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology* / Q000556:secondary; D010641:Phenotype