[The role of autocrine motility factor receptor in metastasis].
Locomotion of tumor cells and its regulation are thought to be crucial for metastasis. Autocrine motility factor (AMF) is a cytokine which stimulates in vitro motility and in vivo lung-colonizing ability of tumor cells via a receptor, a cell surface glycoprotein of 78kD (gp78)-mediated signaling pathway. AMF induces gp78 internalization to intracellular tubulovesicles including lysosome and transport to the leading edge. The AMF-gp78 complex internalization from the cell surface is involved in control of cell motility during metastasis.
Dept. of Orthopedic Surgery, Gunma University School of Medicine.
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Watanabe
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Chigira
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D002465:Cell Movement; D005354:Fibrosarcoma / Q000378:metabolism / Q000473:pathology; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology*; D060285:Receptors, Autocrine Motility Factor; D011956:Receptors, Cell Surface / Q000502:physiology*; D018121:Receptors, Cytokine; D014407:Tumor Cells, Cultured; D044767:Ubiquitin-Protein Ligases
D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; C555000:AMFR protein, human; D060285:Receptors, Autocrine Motility Factor; D044767:Ubiquitin-Protein Ligases; D005956:Glucose-6-Phosphate Isomerase