Humanized antibodies.
Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.
Winter
G
G
MRC Laboratory of Molecular Biology, Cambridge, UK.
Harris
W J
WJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000276:immunology; D003198:Computer Simulation; D005803:Genes, Immunoglobulin / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D015202:Protein Engineering; D017434:Protein Structure, Tertiary
D000911:Antibodies, Monoclonal