Superoxide anion generation from peripheral blood neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine in oromaxillary cancer patients.
Superoxide anion (O2-) generation levels in peripheral blood neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine were evaluated in patients with oromaxillary cancer. The levels in patients with benign tumors were nearly equal to those of normal controls. Patients with squamous cell carcinoma in stage I and II had levels that were widely distributed. On the other hand, O2- generation levels in the advanced stages (III and IV) of squamous cell carcinoma showed lower levels than those of controls (P < .01). All cases of oromaxillary carcinoma showed low levels of O2- generation within 1 month before death compared with controls (P < .01). The generation levels of O2- in the posttreatment period were lower than those before combination cancer treatments. Among cancer treatments such as chemotherapy, surgery, and irradiation, the latter had the strongest effects on O2- generation. These results suggest that low levels of O2- generation by peripheral blood neutrophils may reflect a worsening status of oromaxillary cancer patients.
Harada
T
T
Department of Oral and Maxillofacial Surgery, Shimane Medical University, Izumo City, Japan.
Obara
S
S
Yoshimura
Y
Y
D000230:Adenocarcinoma / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D003131:Combined Modality Therapy; D005260:Female; D006099:Granuloma / Q000276:immunology; D006391:Hemangioma / Q000276:immunology; D006801:Humans; D008223:Lymphoma / Q000276:immunology; D008297:Male; D008441:Maxillary Neoplasms / Q000276:immunology*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000276:immunology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009367:Neoplasm Staging; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D012516:Osteosarcoma / Q000276:immunology; D011379:Prognosis; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine