L-AP3 does not antagonize hippocampal synaptic depression induced by 1S,3R-ACPD.
1-Aminocyclopentane-trans-1S,3R-dicarboxylic acid (1S,3R-ACPD), a compound which selectively activates a metabotropic glutamate receptor (mGluR), suppresses hippocampal excitatory synaptic transmission. This depression is not antagonizable by L-2-amino-3-phosphonoproprionic acid (L-AP3), an agent which counteracts mGluR-induced phosphoinositide (PI) metabolism in several neuronal systems. Therefore, we believe that 1S,3R-ACPD activates a novel hippocampal mGluR subtype that is either insensitive to L-AP3 blockade and/or linked to an effector system that does not involve PI turnover.
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada.
J W
JW
Goh
M A
MA
Musgrave
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003712:Dendrites / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D005110:Extracellular Space / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D066298:In Vitro Techniques; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects*
D010716:Phosphatidylinositols; C000211:2-amino-3-phosphonopropionic acid; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D000409:Alanine