4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity.
Crawley
G C
GC
Chemistry 1 Department, ICI Pharmaceuticals, Mereside, Macclesfield, Cheshire, UK.
Briggs
M T
MT
Dowell
R I
RI
Edwards
P N
PN
Hamilton
P M
PM
Kingston
J F
JF
Oldham
K
K
Waterson
D
D
Whalley
D P
DP
D000818:Animals; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis*; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D016859:Lipoxygenase Inhibitors; D011714:Pyrans; D015363:Quinolones; C075799:ICI D2138; D007975:Leukotriene B4