A possible role for Epstein-Barr virus in tumorigenesis after immunosuppression in cases of renal transplantation.
Eight secondary malignancies developing after renal transplantation were investigated in terms of a possible role of the Epstein-Barr virus (EBV). In five cases, four gastric cancers and one colonic cancer, the presence of EBV was proven by the polymerase chain reaction (PCR), all four gastric lesions being confirmed to have a massive EBV infection by in situ hybridization. Two cases demonstrated monoclonal infection with EBV, as indicated by a single band of the lymphocyte-defined membrane antigen tandem-repeat gene using PCR, and were immunohistochemically positive for the latent membrane protein 1. Our series suggests that gastrointestinal cancer predominates as a secondary malignancy in states of induced severe immunosuppression, and that EBV may play an important role in tumorigenesis as an oncovirus.
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
T
T
Suzuki
Y
Y
Takano
K
K
Yamashita
K
K
Sato
A
A
Kakita
M
M
Okudaira
D000328:Adult; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000382:microbiology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000382:microbiology*; D014412:Tumor Virus Infections / Q000150:complications* / Q000382:microbiology