[Correlations of the levels of HbA1c with plasma apoproteins and plasma lipoproteins in type II diabetic patients].
Plasma apolipoproteins from VLDL, LDL and HDL lipoproteins were measured in 56 male patients with age range 50-60 years and noninsulin-dependent diabetes mellitus (type II) and 81 normal volunteers. Diabetic patients were further divided into two subgroups according to the HbA1c (glycated haemoglobin) concentrations, lower than 7% and higher than 7% respectively, after considering that HbA1c levels may be an appropriate index to monitor long-term blood glucose level. The studied groups, control and diabetic patients, were well matched with regard to age, % of smokers, % drinkers and % hypertensive and physical activity. The relationships between glucose, fructosamine and % HbA1c levels were investigated. In addition, the relationships between glucose, fructosamine, HbA1c levels and apolipoproteins from the lipoproteins were also studied. A significant correlation (p < 0.05) between glucose/fructosamine, glucose/HbA1c and fructosamine/HbA1c was found in both groups of diabetic patients with HbA1c lower than 7% and higher than 7% respectively. However HbA1c levels were positive and significantly (p < 0.05) correlated with the Apo-B and Apo-E and negative but significantly correlated (p < 0.05) with Apo-CII and Apo-CIII from VLDL particle in both groups of diabetic patients.
Laboratorio de Técnicas Instrumentales, Departamento de Nutrición y Bromatología II, Facultad de Farmacia, Madrid, España.
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D001053:Apolipoproteins / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis*; D006595:Hexosamines / Q000097:blood; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001053:Apolipoproteins; D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines; D008074:Lipoproteins