GABA rho 2 receptor pharmacological profile: GABA recognition site similarities to rho 1.
The rho 2 receptor for gamma-aminobutyric acid (GABA) induces GABA-gated currents when expressed as a homooligomer in Xenopus oocytes. rho 2 responses display pharmacological profiles similar to those of expressed rho 1 receptors, although responses were slower, most agonists were more potent at rho 2 and Im values for the partial agonist imidazole-4-acetic acid were 7-fold higher. Amino acids important for most aspects of GABA agonist ligand recognition may not be among those that differ between rho 1 and rho 2, including the 20% amino acid difference in the N-terminal region.
Addiction Research Center, National Institute on Drug Abuse, NIH, Baltimore, MD.
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Kusama
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Wang
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Guggino
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Cutting
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Uhl
D000818:Animals; D003001:Cloning, Molecular; D004247:DNA; D009865:Oocytes; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D014981:Xenopus
D011963:Receptors, GABA-A; D004247:DNA