Anti-inflammatory activity of two flavonoids from Tanacetum microphyllum.
The CH2Cl2 extract of Tanacetum microphyllum aerial parts exhibited anti-inflammatory activity and yielded two anti-inflammatory flavonoids: 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone (centaureidin) [1], and 5,3'-dihydroxy-4'-methoxy-7-carbomethoxyflavonol [2]. This is the first report of the chemical composition of Ta. microphyllum and of the isolation of centaureidin from the genus Tanacetum.
Abad
M J
MJ
Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
Bermejo
P
P
Villar
A
A
Valverde
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D044948:Flavonols; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013030:Spain; D013056:Spectrophotometry, Ultraviolet
C083162:5,3'-dihydroxy-4'-methoxy-7-carbomethoxyflavonol; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; C083161:centaureidin; D002351:Carrageenan