Signalling properties of lysophosphatidic acid.
Lysophosphatidic acid (LPA) is the simplest natural phospholipid, primarily known as a membrane component and metabolic intermediate. However, a remarkable variety of biological effects of this compound have come to light, seemingly pointing to an additional role for LPA as a signalling molecule. In this review, Marcel Durieux and Kevin Lynch integrate the recent information that indicates that LPA could be an intercellular messenger, possibly acting through a G protein-coupled receptor, and with a role in cell growth and motility.
Durieux
M E
ME
University of Virginia, Charlottesville 22908.
Lynch
K R
KR
D000818:Animals; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008246:Lysophospholipids