Pulmonary involvement by mycosis fungoides. A case showing angiocentric lesions and granulomas.
We describe an unusual case of pulmonary involvement by mycosis fungoides in a 31-year-old woman. Disseminated disease had developed despite cutaneous irradiation and systemic combination chemotherapy. Microscopy of biopsied tumour deposits in the lung showed a polymorphous, angiocentric lymphoid infiltrate, including atypical cells with convoluted nuclei which displayed a T-cell phenotype. Numerous epithelioid granulomas were also present. These histological appearances represent an unusual pattern of pulmonary involvement by disseminated mycosis fungoides.
Department of Pathology, University Hospital of Wales, Cardiff, U.K.
P A
PA
Kitching
A R
AR
Gibbs
D000328:Adult; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology*; D009182:Mycosis Fungoides / Q000150:complications / Q000473:pathology* / Q000628:therapy; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy