Antimycotic susceptibility testing of agents of black grain eumycetoma.
Antimycotic susceptibility testing of 17 strains of eumycetes including Madurella mycetomatis, Madurella grisea, Pyrenochaeta romeroi, Exophiala jeanselmei and Leptosphaeria tompkinsii, isolated from cases of black grain mycetoma, was carried out against ketoconazole, itraconazole, miconazole and econazole by broth microdilution and agar dilution methods. Itraconazole and ketoconazole were more active inhibiting 50% of the strains (MIC 50) at 0.5 and 1 microgram ml-1 and 90% (MIC 90) at 2.5 and 5 micrograms ml-1, respectively. The MIC 50s of econazole and miconazole were 2.5 and 5 micrograms ml-1 and MIC 90s 10 micrograms ml-1 for both drugs.
Institute of Microbiology, Madras Medical College, India.
P V
PV
Venugopal
T V
TV
Venugopal
E S
ES
Ramakrishna
S
S
Ilavarasi
D000935:Antifungal Agents / Q000494:pharmacology*; D004464:Econazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D013045:Species Specificity
D000935:Antifungal Agents; D017964:Itraconazole; D004464:Econazole; D008825:Miconazole; D007654:Ketoconazole