A minute deletion of the Y chromosome in men with azoospermia.
We analyzed deoxyribonucleic acid from 50 Japanese men with azoospermia whose Y chromosomes were cytogenetically normal. A total of 26 loci was examined in each patient. Of these patients 6 had small interstitial deletions, each of which was located within the distal part of Yq11. Five of these 6 patients lacked the same 2 loci, DYS7C and DYS1, while 1 patient had a larger deletion including DYS7C but not DYS1. More than 10% of all men with azoospermia of unknown origin may have minute interstitial deletions of the Y chromosome surrounding the DYS7C locus. The proximal part of this zone presumably encompasses the gene deletion that causes azoospermia.
Department of Human Genetics, School of International Health, University of Tokyo, Japan.
S
S
Nagafuchi
M
M
Namiki
Y
Y
Nakahori
N
N
Kondoh
A
A
Okuyama
Y
Y
Nakagome
D000328:Adult; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D014998:Y Chromosome / Q000648:ultrastructure*
D004247:DNA