A characterization of major salivary gland flow rates in the presence of medications and systemic diseases.
The purpose of this study was to characterize the effects of medications and systemic diseases on major salivary gland flow rates. Unstimulated and 2% citrate-stimulated parotid and submandibular salivas were collected from 293 subjects of the oral physiology component of the Baltimore Longitudinal Study of Aging. The influence of the number of medications and diseases on salivary flow rates was determined by separate one-way ANOVA tests. There was an overall decrease in both parotid and submandibular flow rates with increasing numbers of medications and systemic diseases. However, this was significant (p < 0.05) only for unstimulated submandibular flow rates (with increasing numbers of systemic diseases) and stimulated submandibular flow rates (with increasing numbers of systemic diseases and medications). Unstimulated flow rates rapidly approached zero with increasing numbers of medications and diseases. These results suggest that the submandibular gland may be more sensitive to physiologic permutations than the parotid gland. In addition, individuals being treated for multiple systemic diseases and taking numerous medications may be more susceptible to salivary hypofunction.
Clinical Investigations and Patient Care Branch, National Institute of Dental Research, Bethesda, MD.
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004194:Disease; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000187:drug effects / Q000503:physiopathology; D012044:Regression Analysis; D012469:Salivary Glands / Q000187:drug effects* / Q000503:physiopathology*; D012472:Salivation / Q000187:drug effects* / Q000502:physiology; D012636:Secretory Rate; D013363:Submandibular Gland / Q000187:drug effects / Q000503:physiopathology; D014987:Xerostomia / Q000209:etiology