[Correlation of lipid peroxidation intensity and insulin reception in adipocytes].
Influence of prooxidants (cumene hydroperoxide and Fe2+) on insulin reception by adipocytes was studied in experimental conditions. Cumene hydroperoxide (10(-7) M) in the presence of Fe2+ (0.2 mM) increased the specific binding of the hormone. The higher concentrations (10(-6)-10(-3) M) of the prooxidant resulted in significant accumulation of malonic dialdehyde and inhibited insulin binding by fat tissue cells. The inhibition of insulin specific binding was shown to occur due to a decrease in the content of insulin receptors as well as in the rate of their affinity to the hormone.
V V
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Ivanov
M P
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Stennikova
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D007501:Iron / Q000494:pharmacology; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism*
D001555:Benzene Derivatives; D007328:Insulin; D008315:Malondialdehyde; D007501:Iron; D011972:Receptor, Insulin; C007164:cumene hydroperoxide