Differential down-regulation of estrogen receptor-like immunoreactivity by estradiol in the female Brazilian opossum brain.
The effects of estrus and prolonged estradiol benzoate (EB) treatment on estrogen receptor-like immunoreactivity (ER-LI) were studied in the female Brazilian opossum (monodelphis domestica) brain. In general, both estrus animals and EB treated animals had reduced ER-LI in specific brain regions when compared to ovariectomized controls. These results support a down-regulatory role for estrogen in relation to its receptor in the brain, and indicate that ER-LI is differentially regulated in the Monodelphis forebrain.
Pearson
P L
PL
Department of Veterinary Anatomy, Iowa State University, Ames 50011.
Ross
L R
LR
Jacobson
C D
CD
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D015536:Down-Regulation / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D009893:Opossums / Q000378:metabolism*; D010053:Ovary / Q000502:physiology; D011960:Receptors, Estrogen / Q000032:analysis*
D011960:Receptors, Estrogen; D004958:Estradiol