T-cell-dependent immunobiological activity of a desmuramyl analog of muramyl dipeptide, adamantylamide dipeptide (AdDP), and D-isoglutamine.
The present experiments demonstrate that, similar to immunomodulatory muramyl dipeptide, its desmuramyl analog adamantylamide dipeptide is able to induce mild and fully reversible paw edema in mice. This effect is an immune-related phenomenon depending on the activation of T-cell/macrophage interactions and on production of prostaglandins. Possible involvement of certain immunoregulatory/inflammatory cytokines (e.g. IL-1, IL-2) has been suggested. The most probable intrinsic moiety of the adamantylamide dipeptide molecule responsible for triggering the edema formation is obviously D-isoglutamine.
Institute of Pharmacology, Czech Academy of Sciences, Prague.
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Zídek
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K
Masek
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Franková
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M
Flegel
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000547:Amantadine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control; D005260:Female; D005973:Glutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D013237:Stereoisomerism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000276:Adjuvants, Immunologic; D000961:Antilymphocyte Serum; D004151:Dipeptides; D005973:Glutamine; C059858:isoglutamine; D003907:Dexamethasone; C044891:adamantylamide-alanyl-isoglutamine; D000547:Amantadine; D007213:Indomethacin