Paracetamol in rheumatoid arthritis.
The need for supplementary analgesic treatment in RA has partially been neglected. Increasing evidence now support that paracetamol supplementation can increase the effect of NSAIDs. A hypothesis may be postulated that prostaglandin (PG) mediated anti-inflammatory effects of NSAIDs are only marginally increased by higher NSAID doses and that non PG mediated analgesic effects obtained at higher NSAID doses may instead be obtained by supplementing NSAIDs with paracetamol. Combined paracetamol treatment may increase the effect and decrease dose-dependent side-effects of NSAIDs.
Department of Internal Medicine, Karolinska Institute, Danderyd Hospital, Sweden.
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D000082:Acetaminophen / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D009288:Naproxen / Q000008:administration & dosage / Q000009:adverse effects
D000082:Acetaminophen; D009288:Naproxen