Salivary proline-rich proteins: biochemistry, molecular biology, and regulation of expression.
The proline-rich proteins (PRPs) in mammalian salivary glands are encoded by tissue-specific multigene families whose members have diverged with respect to structure and regulation of expression. PRPs are expressed constitutively in humans, and comprise about [70%] of the total salivary proteins. Families of similar proteins are dramatically increased or induced in parotid and submandibular glands of rats, mice and hamsters by treatment with the [beta-] agonist isoproterenol. Feeding tannins to rats and mice mimics the effects of isoproterenol on the parotid glands. Salivary PRPs may constitute a defense mechanism against tannins and other polyhydroxylated phenols ingested. Putative transcriptional regulatory sequences have been identified in mouse PRP genes.
Department of Biochemistry and Biophysics, University of California, Davis 95616.
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Carlson
D000595:Amino Acid Sequence; D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D005786:Gene Expression Regulation; D006801:Humans; D008967:Molecular Biology; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000235:genetics*; D011392:Proline / Q000737:chemistry* / Q000235:genetics*; D055232:Proline-Rich Protein Domains; D012471:Salivary Proteins and Peptides / Q000737:chemistry* / Q000235:genetics*
D010455:Peptides; D012471:Salivary Proteins and Peptides; D011392:Proline