Azithromycin for treatment of severe Cryptosporidium diarrhea in two children with cancer.
Two children with cancer received azithromycin for Cryptosporidium-associated diarrhea that was unresponsive to supportive care. One child had choleriform diarrhea requiring daily fluid replacement of up to 65% of his total body weight; the other had protracted diarrhea and wasting. In both cases, administration of azithromycin was followed by prompt clinical improvement.
Vargas
S L
SL
Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, TN 38105-2794.
Shenep
J L
JL
Flynn
P M
PM
Pui
C H
CH
Santana
V M
VM
Hughes
W T
WT
D000284:Administration, Oral; D017963:Azithromycin; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000209:etiology; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D003968:Diarrhea, Infantile / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005440:Fluid Therapy; D006801:Humans; D007223:Infant; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications*; D009447:Neuroblastoma / Q000150:complications*; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000209:etiology; D012509:Sarcoma / Q000150:complications*
D004917:Erythromycin; D017963:Azithromycin