[The permeability of the hemato-encephalic barrier for superoxide dismutase following the unilateral intracarotid hyperperfusion of the cerebral vessels].
On the model of acute blood-brain barrier injury in rats after a short-term hyperperfusion of one brain hemisphere with blood, the injection of exogenic superoxide dismutase (SOD) was accompanied by pronounced increase in the activity of SOD in the damaged brain tissue. This fact and other data of the authors on this model confirm the penetration of SOD over the microvessel endothelium into the extracellular space of the same damaged brain areas that are permeable for plasma albumin.
Aleksandrova
L A
LA
Sorokoumova
V A
VA
Shabunevich
L V
LV
Pugacheva
E L
EL
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000201:enzymology; D001929:Brain Edema / Q000201:enzymology; D002343:Carotid Artery, Internal; D002463:Cell Membrane Permeability; D002536:Cerebral Arteries; D010477:Perfusion / Q000379:methods; D051381:Rats; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013482:Superoxide Dismutase