[The mechanism of action of selenium substitution in inflammatory diseases. Modification of the activity of antioxidative enzymes in patients with acute pancreatitis].
From 20 patients with acute pancreatitis the activities of the antioxidative enzymes glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were estimated in the blood serum immediately before and during therapy with sodium selenite. The results demonstrate significant (p < 0.01 respectively < 0.05) enhanced activities of GSH-Px under the selenite therapy. Serum SOD activities were not significant influenced by the selenium treatment. The results obtained were not dependent on the reference basis (units/mg protein or U/l serum) used.
Institut für Pharmakologie und Toxikologie, Medizinischen Fakultät der Universität Rostock.
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Zelck
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Karnstedt
D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000201:enzymology; D012643:Selenium / Q000008:administration & dosage*; D018038:Sodium Selenite; D013482:Superoxide Dismutase / Q000097:blood*; D014057:Tomography, X-Ray Computed
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D018038:Sodium Selenite