HGF-SF: effects on motility and morphology of normal and tumor cells.
HGF-SF is a recently discovered cytokine which has both mitogenic and motogenic effects on a wide variety of cells. We used a computerized digital imaging system to measure motility and morphology of isolated cells. In this chapter we will describe the effect of HGF-SF and of other growth factors on the velocity, area, circularity, and flatness of normal and tumor cells. We will then discuss the possible mechanism of HGF-SF induced motility and the possible role of this factor in biological and pathological processes.
Department of Radiation Oncology, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
M M
MM
Bhargava
Y
Y
Li
A
A
Joseph
L
L
Jin
E M
EM
Rosen
I D
ID
Goldberg
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects* / Q000648:ultrastructure; D002465:Cell Movement / Q000187:drug effects*; D006133:Growth Substances / Q000494:pharmacology; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met; D011519:Proto-Oncogenes; D011956:Receptors, Cell Surface / Q000378:metabolism; D014407:Tumor Cells, Cultured
D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met