Use of serum specific immunoglobulin antibodies to determine Helicobacter pylori associated gastritis.
A prospective study in 169 consecutive patients referred for upper gastrointestinal endoscopy was initiated to investigate the diagnostic performance of serum Helicobacter pylori (HP) specific immunoglobulin (Ig) G antibodies. Using an enzyme linked immunosorbent assay (ELISA) an excellent correlation between serologic evidence of HP and the demonstration of this organism by histology and urease test in 79 HP-positive patients was found. Serum IgG also correlated with the histological degree and the activity of gastritis. Our results demonstrate that serum IG G antibodies, as determined by ELISA, are highly useful for diagnosis of HP-associated gastritis.
Medizinische Poliklinik, University of Würzburg.
W
W
Fischbach
K
K
Wosnik
T
T
Kirchner
J
J
Mössner
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis*; D001706:Biopsy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000175:diagnosis* / Q000276:immunology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D014510:Urease / Q000032:analysis
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D014510:Urease