[A new trial of plachitin particles for intraarterial chemoembolization therapy in rabbit].
Plachitin, which is reconstituted by the combination of CDDP and chitin, has been reported to have a slow releasing property of CDDP and an antitumor effect. The antitumor effect and pharmacokinetics of Plachitin for intraarterial chemoembolization therapy were studied in rabbits using VX2 tumor inoculated in the hind limb. One gram of Plachitin contained 300 mg CDDP, and the form of Plachitin was modified into particles (about 50 microns in diameter). Plachitin was injected into the femoral artery. The study was carried out in four groups. The tumor growth ratio was significantly lower in the Plachitin group than in the CDDP, chitin, and control groups (p < 0.05). Tumor regression was noticed only in the Plachitin group. The tumor platinum (Pt.) level was higher than the serum Pt. level for 5 days after Plachitin injection. From the above results it can be concluded that Plachitin particles released CDDP slowly around the tumor and the tumor growth was suppressed by the additive effect of CDDP and embolization. Plachitin was considered a useful agent for chemoembolization therapy for the cancer patients.
Tabara
H
H
2nd Dept. of Surgery, Shimane Medical University.
Matsuura
H
H
Tachibana
M
M
Yoshimura
H
H
Kotoh
T
T
Dhar
D K
DK
Nagasue
N
N
Nakamura
T
T
Kifune
K
K
Tsurutani
R
R
D000818:Animals; D016461:Chemoembolization, Therapeutic; D002686:Chitin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011817:Rabbits
D003692:Delayed-Action Preparations; D004338:Drug Combinations; C083092:plachitin; D002686:Chitin; D002945:Cisplatin