Molecular mechanisms of trauma-induced neuronal degeneration.
Recent studies suggest that various neuron-specific responses, including activation of glutamate receptors, muscarinic receptors, and oxidative stress, contribute to the events leading to brain and spinal cord neuronal degeneration after trauma. These specific mechanisms and possible future treatments are highlighted in this review.
Lipton
S A
SA
Children's Hospital, Boston, Massachusetts.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001921:Brain / Q000503:physiopathology; D001930:Brain Injuries / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D009410:Nerve Degeneration / Q000502:physiology*; D017459:Receptors, Amino Acid / Q000502:physiology*; D017470:Receptors, Glutamate / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000503:physiopathology*
D017459:Receptors, Amino Acid; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D000109:Acetylcholine