Investigation in healthy volunteers to evaluate serum concentrations and urinary excretions of aluminium, magnesium, calcium and phosphate after multiple administration of hydrotalcit (Talcid) suspension.
The aim of this study was to evaluate the extent of aluminium absorption after repeated administration of Talcid suspension. Therefore, the serum concentrations of aluminium and the amount of urinary excreted aluminium were determined. Furthermore, the influence of repeated Talcid administration on serum concentrations and urinary excretion of magnesium, calcium and phosphate was studied. The trial was carried out as a randomized, double-blind, parallel-group, placebo-controlled investigation in 17 healthy male volunteers and 1 female volunteer, aged between 18-34 years.
Wölke
E
E
Clinical Research Foundation Deutschland, Institut Freiburg (Biodesign).
Seiberling
M
M
Schepers
C
C
Roos
U
U
Franke
H
H
Bernhard
I
I
D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000097:blood / Q000652:urine; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000652:urine; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D010710:Phosphates / Q000097:blood / Q000652:urine; D013535:Suspensions
D000863:Antacids; D010710:Phosphates; D013535:Suspensions; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D000535:Aluminum; D008274:Magnesium; D008276:Magnesium Hydroxide; D002118:Calcium