Monoclonal gammopathy (IgA: lambda) after autologous T-cell-depleted bone marrow transplantation in a patient with non-Hodgkin's lymphoma.
We report a case study of a patient suffering from T-lymphoblastic lymphoma, for whom autologous T-cell-depleted bone marrow transplantation was carried out. Low-dose cyclosporin A (CsA) was administered just after autologous bone marrow transplantation (ABMT) for induction of autologous graft-versus-host disease. Three months later, the lymphoma relapsed with marked monoclonal gammopathy of the immunoglobulin A type, which had not been seen before ABMT. It is suggested that the regrowth of the lymphoma cells was related to the maturation of B cells or the secretion of immunoglobulins from plasma cells, associated with some cytokines produced under the condition of an abnormal immunological circumstance after ABMT plus CsA.
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
S
S
Hashino
M
M
Imamura
S
S
Kobayashi
H
H
Kobayashi
M
M
Kasai
T
T
Miyazaki
D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods; D006801:Humans; D008212:Lymphocyte Depletion; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000601:surgery; D008297:Male; D010265:Paraproteinemias / Q000150:complications*; D013601:T-Lymphocytes