Investigations on the synthesis and properties of some N-heteroarylpiperazinylalkyl derivatives of imides of 3,4-pyridinedicarboxylic acids.
The synthesis of N-heteroarylpiperazinylalkyl derivatives of imides of 3,4-pyridinedicarboxylic acids is described. In pharmacological screening some of the obtained compounds proved to be pharmacologically active.
Department of Chemistry of Drugs, School of Medicine, Wroclaw, Poland.
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Sladowska
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Dereń-Wesolek
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects; D006380:Helplessness, Learned; D007094:Imides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011805:Quinolinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000927:Anticonvulsants; D007094:Imides; D010879:Piperazines; D011619:Psychotropic Drugs; D011805:Quinolinic Acids; D017366:Serotonin Receptor Agonists; D012110:Reserpine; D001058:Apomorphine; C015068:1-(3-chlorophenyl)piperazine