Expression of hydra head activator in newt tissues and effects on limb regeneration.
In this study, the presence of the hydra head activator (HHA) neuropeptide and its influence on regenerating newt limbs (Notophthalmus viridescens) was investigated. Immunohistological analysis has localized the HHA neuropeptide in the adult newt brain, eye, intestine, and regenerating blastema. Experiments in which 9 day limb regenerates were denervated and subsequently implanted with HHA-soaked beads suggest a slight progression of blastema growth compared to denervated controls.
Fuentes
E J
EJ
Department of Biology, University of Dayton, OH 45469-2320.
Mescher
A L
AL
Ekman
R
R
Tsonis
P A
PA
D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D005121:Extremities / Q000502:physiology*; D005123:Eye / Q000737:chemistry; D007150:Immunohistochemistry; D007422:Intestines / Q000737:chemistry; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000032:analysis*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D012038:Regeneration / Q000502:physiology*; D012455:Salamandridae / Q000378:metabolism*
D009479:Neuropeptides; C032522:head activator peptide; D000242:Cyclic AMP; D006152:Cyclic GMP; D011761:Pyrrolidonecarboxylic Acid