A Saccharomyces cerevisiae cyclophilin resident in the endoplasmic reticulum.
Cyclophilins are cyclosporin A sensitive peptidyl-prolyl cis-trans isomerases found in the cytoplasm of a wide range of species from Escherichia coli to man. Cyclophilin homologues are translocated into mitochondria, the endoplasmic reticulum and the bacterial periplasmic space. Here, the nucleotide sequence of a non-essential fifth Saccharomyces cerevisiae cyclophilin homologue encoded by chromosome XII is presented. As expected from its hydrophobic signal sequence and a hydrophilic carboxy terminus ending in the tetrapeptide HDEL, epitope-tagged cyclophilin D was found associated with the endoplasmic reticulum.
Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, England.
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Frigerio
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Pelham
D000591:Amino Acid Isomerases / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D000595:Amino Acid Sequence; D001483:Base Sequence; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D002451:Cell Compartmentation; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism; D005800:Genes, Fungal / Q000235:genetics*; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D009842:Oligopeptides / Q000235:genetics / Q000276:immunology; D019696:Peptidylprolyl Isomerase; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D002352:Carrier Proteins; D009842:Oligopeptides; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase