Antimicrobial effects of a new carboxyquinolone drug, Q-35, on five serogroups of Leptospira interrogans.
New carboxyquinolone drugs, including the recently developed Q-35, were evaluated for their in vitro potency against five serogroups of Leptospira interrogans. Q-35, ofloxacin, ciprofloxacin, and tosufloxacin showed MICs (0.05 to 0.20 microgram/ml) comparable to those of tetracycline. However, MBCs of these drugs varied between 10- and 100-fold above the MIC for most strains tested. Q-35 was shown to be active against L. interrogans in vitro as judged by the MICs obtained.
Takashima
I
I
Department of Veterinary Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Ngoma
M
M
Hashimoto
N
N
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D007700:Kinetics; D007921:Leptospira interrogans / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009391:Nephelometry and Turbidimetry; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C077155:balofloxacin