Possible mechanisms of action of antimalarials in rheumatic disease.
Understanding of the mechanism of action of the antimalarials in rheumatoid arthritis remains limited in spite of knowledge of a wide range of potentially relevant effects at the cellular level. Among the difficulties with proposed mechanisms of action are a lack of specificity, doubt about demonstrable effects at appropriate concentrations and a failure to explain the slow onset of action. It is possible that pharmacokinetic factors, or the slow change in the underlying disease pathology, might account for the slow onset.
Cutler
D J
DJ
Department of Pharmacy, University of Sydney, Australia.
D002477:Cells / Q000187:drug effects; D002738:Chloroquine / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D006886:Hydroxychloroquine / Q000493:pharmacokinetics / Q000494:pharmacology*; D007700:Kinetics; D012216:Rheumatic Diseases / Q000188:drug therapy* / Q000378:metabolism
D006886:Hydroxychloroquine; D002738:Chloroquine