Temporal changes in ACTH, cortisol and IAP in rats under immunochemotherapy with 5-FU and Krestine.
In this study we investigated temporal changes in both the endocrine system and immunity in rats under immunochemotherapy with 5-FU and Krestine (PSK). This immunochemotherapy was performed on two types of groups, non-cancer-bearing rats and cancer-bearing rats. As hosts, inbred strain WKA/HA 5-week-old male rats and as tumors, transplantable ascitic liver cancer KDH-8 cells were used. Our results indicated that 1) in the non-cancer-bearing rats, 5-FU administration led to an increase in serum cortisol and IAP, however, PSK concurrent administration clearly lowered the levels of cortisol and IAP; 2) in the cancer-bearing rats, the levels of ACTH, cortisol and IAP increased as the cancer progressed, but in the immunothemotherapy administration groups these levels were lower; 3) the immunothemotherapy administration group had greater effects on both tumor growth and liver metastasis.
Takenoshita
S
S
First Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
Hashizume
T
T
Asao
T
T
Nakamura
J
J
Yajima
Y
Y
Shinozaki
K
K
Katoh
R
R
Nagamachi
Y
Y
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011509:Proteoglycans / Q000008:administration & dosage; D051381:Rats; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D009363:Neoplasm Proteins; D011509:Proteoglycans; C030193:immunosuppressive acidic protein; C010770:polysaccharide-K; D000324:Adrenocorticotropic Hormone; D005472:Fluorouracil; D006854:Hydrocortisone