Introduction: protein phosphorylation and signal transduction in bacteria.
A single type of reversible protein-phosphorylating system, the ATP-dependent protein kinase/phosphatase system, is employed in signal transduction in eukaryotes. By contrast, recent work has revealed that three types of protein-phosphorylating systems mediate signal transduction in bacteria. These systems are (1) classical protein kinase/phosphatase systems, (2) sensor-kinase/response-regulator systems, and (3) the multifaceted phosphoenolpyruvate-dependent phosphotransferase system. Physiological, structural, and mechanistic aspects of these three evolutionarily distinct systems are discussed in the papers of this written symposium.
Saier
M H
MH
Department of Biology, University of California at San Diego, La Jolla 92093-0116.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000494:Allosteric Regulation; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000378:metabolism*; D008954:Models, Biological; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
D001426:Bacterial Proteins; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; D010749:Phosphoprotein Phosphatases