Tight junctional structure and permeability of porcine jejunum after enterotoxic Escherichia coli infection.
Tight junctional structure and macromolecular permeability were tested in four three-week-old piglets, experimentally infected with the enterotoxigenic Escherichia coli (ETEC) strain O149 K91 K88. Histologically, only minor microscopic evidence of inflammation and little or no architectural changes in the jejunal mucosa were observed. A significant decrease in tight junctional strand numbers occurred, without a concomitant decrease in tight junctional depth. The permeability of the porcine jejunal epithelium to horseradish peroxidase did not change after the ETEC infection.
Egberts
H J
HJ
Department of Veterinary Pathology, State University of Utrecht, The Netherlands.
de Groot
E C
EC
van Dijk
J E
JE
Vellenga
L
L
Mouwen
J M
JM
D000818:Animals; D002463:Cell Membrane Permeability; D004927:Escherichia coli Infections / Q000473:pathology*; D005614:Freeze Fracturing; D006735:Horseradish Peroxidase; D007365:Intercellular Junctions / Q000378:metabolism / Q000648:ultrastructure*; D007583:Jejunum / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D013552:Swine
D006735:Horseradish Peroxidase