Noradrenergic involvement in the consolidation of maternal experience in postpartum rats.
If postpartum rats are separated from pups following cesarean delivery, their maternal responsiveness declines such that in tests on day 10 they show maternal onset latencies that do not differ from those shown by virgin rats. If, however, dams are permitted a 1-h experience with pups within 36 h of cesarean delivery, rats exhibit a high level of responsiveness to foster pups on day 10 after c-section. The present research investigates the effect of the noradrenergic system in the long-term consolidation of a brief maternal experience in new mother rats. Groups of dams were cesarean delivered and were either given pups for a brief period 36 h after section (experienced) or received no experience (inexperienced). Immediately following the experience phase, dams were injected with different concentrations of the beta-adrenergic antagonist, propranolol (0, 0.5, 1.0, 5.0 mg/kg), or the adrenergic agonist, isoproterenol (0, 0.25 or 0.5 mg/kg). Ten days after cesarean delivery rats were given maternal induction tests. Rats receiving 60 min of experience and injected with propranolol exhibited significantly longer maternal onset latencies than did saline-injected rats, although their latencies were not as long as shown by the maternally inexperienced groups. In contrast, rats receiving 15 min of experience and injected with isoproterenol exhibited significantly shorter onset latencies than did saline-injected rats, whether or not they exhibited maternal behavior during the initial 15 min exposure period. These results suggest that the noradrenergic system is involved in the consolidation of a maternal experience.
Erindale College, University of Toronto, Mississauga, Ontario, Canada.
S D
SD
Moffat
E J
EJ
Suh
A S
AS
Fleming
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008425:Maternal Behavior; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology
D011941:Receptors, Adrenergic; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine