[The effect of low doses of dexamethasone on interleukin-2 production by human peripheral blood lymphocytes].
Dose-dependent modifying of mitogen-induced interleukin-2 (IL-2) release by human peripheral blood lymphocytes (PBL) treated with dexamethasone (Dx) was demonstrated. In four independent experiments with PBL of 10 human subjects the effect of Dx administration on IL-2 release in serum-free culture medium could vary from appreciable enhancing to complete suppression. The enhancing effect was observed distinctly with PBL of 7 individuals. A transition from stimulation to suppression of IL-2 production by Dx was essentially observed in the dose range of 10(-9) to 10(-8) M. Thus the glucocorticoid hormones can both increase and decrease the production of L-2 which occupies a central position in the cascade of events involved in the immune response. Mechanisms of IL-2 release modification by Dx are discussed.
Kalashnikova
E A
EA
Pukhal'skiĭ
A L
AL
D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D016895:Culture Media, Serum-Free; D003864:Depression, Chemical; D003907:Dexamethasone / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013268:Stimulation, Chemical
D016895:Culture Media, Serum-Free; D007376:Interleukin-2; D003208:Concanavalin A; D003907:Dexamethasone