Effects of soluble and insoluble fiber preparations isolated from oat, barley, and wheat on liver cholesterol accumulation in cholesterol-fed rats.
Effects of soluble and insoluble fiber preparations isolated from defatted oat, barley, and wheat on liver cholesterol accumulation were examined in cholesterol-fed rats. The soluble and insoluble fiber preparations were isolated by a modification of the procedure of Asp et al. Male Sprague-Dawley rats, aged 5 weeks, were fed a control diet containing 5% cellulose or diets containing soluble and insoluble fiber preparations for 9 days. Soluble fiber preparations from oat, barley, and wheat were added to diets corresponding to 1.9, 2.8, and 0.6% fiber, respectively. Insoluble fiber preparations from oat, barley, and wheat were added to diets corresponding to 3.1, 2.2, and 4.4% fiber, respectively. All of the soluble fiber preparations suppressed liver cholesterol accumulation, but they did not suppress the elevation of plasma cholesterol concentrations. A significant inverse relationship between the quantity of ingested soluble fiber and liver cholesterol accumulation was observed; n = 28, r = -0.943, p < 0.0001. None of the insoluble fiber preparations had any significant effect on liver and plasma cholesterol concentrations. These results indicate that the water-soluble fractions of oat, barley, and wheat are the active components that suppressed liver cholesterol accumulation, and that these effects are related to the quantity of ingested soluble fiber.
Technical Research Institute, Snow Brand Milk Products, Saitama, Japan.
T
T
Oda
S
S
Aoe
H
H
Sanada
Y
Y
Ayano
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D004043:Dietary Fiber / Q000494:pharmacology*; D002523:Edible Grain; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014867:Water
D004043:Dietary Fiber; D014867:Water; D002784:Cholesterol