Minor-groove binders are inhibitors of the catalytic activity of DNA gyrases.
Non-intercalating DNA minor-groove binders may effectively inhibit the supercoiling activity of gyrases by influencing the enzyme recognition and cleavage site on DNA. For gyrase from Streptomyces noursei a wide range of inhibitory potency for different classes of ligands is observed. This can be explained by a number of structural and binding factors of the ligands competing with the gyrase on the target site of DNA, the mechanism of which is different from the classical gyrase inhibitors.
Department of Molecular Biology, University of Jena, Germany.
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Störl
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J
Störl
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C
Zimmer
J W
JW
Lown
D000818:Animals; D001483:Base Sequence; D002384:Catalysis; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D008969:Molecular Sequence Data; D009429:Netropsin / Q000378:metabolism / Q000494:pharmacology; D013302:Streptomyces / Q000201:enzymology; D059005:Topoisomerase II Inhibitors
D059005:Topoisomerase II Inhibitors; D009429:Netropsin; D004247:DNA; D004250:DNA Topoisomerases, Type II