Deletion of chromosome 13 in osteosarcoma secondary to irradiation.
The cytogenetic analysis of a radiation-induced osteosarcoma in a 31-year-old male is presented. Complex karyotypic changes with numerical and structural abnormalities, including a del(13)(q12.3q21.1), were observed. This deletion may indicate that loss of RB1 gene (locus in 13q14) may be involved in the development of radiation-induced osteosarcoma.
Ozisik
Y Y
YY
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Meloni
A M
AM
Zalupski
M M
MM
Ryan
J R
JR
Qureshi
F
F
Sandberg
A A
AA
D000328:Adult; D001859:Bone Neoplasms / Q000209:etiology / Q000235:genetics*; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D005360:Fibula; D016161:Genes, Retinoblastoma; D006801:Humans; D007621:Karyotyping; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000235:genetics*; D012516:Osteosarcoma / Q000209:etiology / Q000235:genetics*; D011878:Radiotherapy / Q000009:adverse effects; D012512:Sarcoma, Ewing / Q000532:radiotherapy; D013977:Tibia