Do cytosolic factors prevent promiscuity at the membrane surface?
From the point of view of a preprotein, escaping from the cytosol into a specific organelle must seem an arduous, almost impossible task. How is it that preproteins resist the temptation to fold prematurely, to avoid the multiple membrane surfaces in the cell, and manage instead to enter only the translocation apparatus of a single organelle?
Department of Biochemistry, La Trobe University, Bundoora, Australia.
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T
Lithgow
P B
PB
Høj
N J
NJ
Hoogenraad
D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D011487:Protein Conformation; D011498:Protein Precursors / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism; D018271:Signal Recognition Particle
D011498:Protein Precursors; D021382:Protein Sorting Signals; D012261:Ribonucleoproteins; D018271:Signal Recognition Particle