Tetrandrine effects on calcium currents in cultured neurones of foetal mice.
Tetrandrine, a bis-benzyl-isoquinoline alkaloid from the roots of Stefania Tetranda blocks calcium currents in cultured neurones of the spinal cord of foetal mice. The concentration of half-maximal effect (Kd) measured 100 ms after the beginning of a depolarizing pulse (-80 mV-0 mV) is 8 microM. While high- and low-voltage activated (HVA, LVA) currents are both blocked by Tetrandrine, the slowly inactivating HVA currents appear to be a primary target.
Bickmeyer
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Medical Institute of Environmental Hygiene, Heinrich-Heine-University, Düsseldorf, Germany.
Wiegand
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D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001464:Barium / Q000378:metabolism; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D004594:Electrophysiology; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects
D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D001464:Barium; C009438:tetrandrine