Transmissibility of the D variant of encephalomyocarditis virus (EMC-D) in mice.
Transmissibility of the D variant of encephalomyocarditis virus (EMC-D) was examined. Eight-week-old ICR:CD-1 male mice inoculated with 10(5) plaque forming units (PFU)/animal of EMC-D intranasally, orally or intraperitoneally showed marked viraemia and prominent pancreatic lesions at 2 days after inoculation (2 DAI), and excreted virus in faeces from 2 to 8 DAI (virus titre: 10(3)-10(5) PFU/g). Only a small proportion of control mice housed with EMC-D-inoculated mice for 10 days developed viraemia and pancreatic lesions.
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
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Doi
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Takeda
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Hirasawa
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Doi
D000818:Animals; D004686:Encephalomyocarditis virus / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000382:microbiology / Q000635:transmission* / Q000652:urine; D005243:Feces / Q000382:microbiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014766:Viremia / Q000382:microbiology / Q000635:transmission* / Q000652:urine