Combined anti-fungal therapy and surgical resection as treatment of disseminated aspergillosis of the lung and brain following BMT.
This report describes a 6-year-old girl with pre-B ALL who developed systemic aspergillosis following BMT. She was successfully treated with a combination of amphotericin B, itraconazole and surgery. This report emphasizes the importance of surgical resection in the management of disseminated aspergillosis.
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.
M E
ME
Trigg
A H
AH
Menezes
R
R
Giller
L
L
Lanza
R J
RJ
Smith
Y
Y
Sato
C
C
Peters
A
A
Altman
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery*; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D007654:Ketoconazole