Higher-titer antisera from patients with periodontal disease inhibit bacterial capsule-induced bone breakdown.
Solubilized surface-associated material (SAM) from a number of periodontopathogenic bacteria have been shown to be potent stimulators of bone resorption in vitro in the murine calvarial bone culture assay. Antibodies to the constituents of SAM are also found in patients with periodontal diseases. Serum from patients with severe generalized periodontitis (SGP) containing high titers of antibodies to the SAM of Porphyromonas gingivalis completely inhibited the bone resorption induced by SAM from this organism. In contrast, serum from patients with low titers of antibodies to SAM from P. gingivalis failed to inhibit bone resorption. High-titer sera (containing antibodies to SAM from Actinobacillus actinomycetemcomitans) from patients with localized juvenile periodontitis (LJP) were added to calvarial cultures stimulated with SAM from A. actinomycetemcomitans. Of 6 high-titer sera tested, only 4 inhibited bone breakdown, the other 2 sera having no effect on resorption. Low-titer sera were also ineffective at blocking bone resorption. This suggests that the antibody response to SAM may have a protective effect in patients with periodontal disease.
Maxillofacial Surgery and Oral Medicine Research Unit, University of London, Eastman Dental Hospital, U.K.
S
S
Meghji
B
B
Henderson
M
M
Wilson
D016976:Aggregatibacter actinomycetemcomitans / Q000737:chemistry / Q000276:immunology; D010520:Aggressive Periodontitis / Q000276:immunology / Q000382:microbiology; D000818:Animals; D000907:Antibodies, Bacterial / Q000502:physiology*; D016667:Bacterial Capsules / Q000276:immunology*; D001862:Bone Resorption / Q000276:immunology* / Q000517:prevention & control; D002118:Calcium / Q000378:metabolism; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D051379:Mice; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000737:chemistry / Q000276:immunology*; D012886:Skull
D000907:Antibodies, Bacterial; D002118:Calcium