Perspective of the pharmaceutical industry on the development of new drugs for heart failure.
Despite recent therapeutic advances, patients with heart failure have considerable morbidity and a markedly shortened life span. The prevalence of heart failure increases with age and is the most common cause of hospital admission in the elderly. In developing innovative remedies for this disorder, the scientific challenges, regulatory agencies' guidelines, physician behavior and marketing requirements must be considered.
Rajfer
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SI
Merck Research Laboratories, Blue Bell, Pennsylvania.
D004345:Drug Industry; D004363:Drug Utilization; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D010818:Practice Patterns, Physicians'; D014481:United States
D015507:Drugs, Investigational