Extracellular calcium modulates proliferation of factor dependent hemopoietic cells.
Blockade of the calcium channel inhibited, in a dose-dependent manner, the proliferation of the IL-3 dependent FDCP-1 cell line and normal murine bone marrow cells. Similar results were obtained by lowering the amount of extracellular calcium using specific chelators or a calcium-free medium. These results suggest that factor-dependent cell proliferation is highly sensitive to fluctuations in the concentration of extracellular calcium.
Unidad de Biología Celular, INTA, Universidad de Chile, Santiago.
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Martínez
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Santibañez
D000818:Animals; D001853:Bone Marrow / Q000254:growth & development* / Q000378:metabolism; D002118:Calcium / Q000172:deficiency / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007377:Interleukin-3 / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D007377:Interleukin-3; D002118:Calcium