Characterisation of equine influenza isolates from the 1987 epizootic in India by nucleotide sequencing of the HA1 gene.
Two A/Equi-2 (H3N8) isolates were obtained during the 1987 Indian equine influenza epizootic. The sequence of the Ludhiana/87 HA1 gene revealed that this isolate was very similar to recent European and North American isolates of equine influenza. In contrast, the Bhiwani/87 HA1 gene was nearly identical to the Miami/63 prototype H3 sequence. These results support the antigenic analysis previously carried out on these isolates using monoclonal antibodies. However, the finding that Bhiwani/87 is so similar to Miami/63, coupled with the finding that equine H3N8 influenza viruses have previously been shown to evolve along a single lineage, suggests that Miami/63 virus from either a vaccine or laboratory source may be the origin of the Bhiwani/87 isolate.
National Research Centre on Equines, Haryana, India.
A K
AK
Gupta
M P
MP
Yadav
P K
PK
Uppal
J A
JA
Mumford
M M
MM
Binns
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000737:chemistry; D004196:Disease Outbreaks / Q000662:veterinary*; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000235:genetics*; D006734:Horse Diseases / Q000453:epidemiology / Q000382:microbiology*; D006736:Horses; D007194:India / Q000453:epidemiology; D009980:Influenza A virus / Q000235:genetics*; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics
D004279:DNA, Viral; D006389:Hemagglutinins, Viral; D012367:RNA, Viral