DNA-dependent RNA polymerase enzymes affected in uraemic lymphocyte cells.
The DNA-dependent RNA polymerase activity and endonucleases in uraemic lymphocyte cells were investigated. It was found that the activity and quantity in three classes of polymerases are remarkably reduced. The reduction in enzyme activity is accompanied by increasing endonuclease activity. The relationship of polymerase enzymes with endonucleases is discussed.
Department of Nephrology and Artificial Kidney, Medical Academy of Wrocław, Poland.
R
R
Adamiec
Z
Z
Szewczyk
J
J
Szopa
D000328:Adult; D012321:DNA-Directed RNA Polymerases / Q000097:blood*; D004591:Electrophoresis, Polyacrylamide Gel; D004720:Endonucleases / Q000097:blood; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D014511:Uremia / Q000097:blood / Q000201:enzymology*
D012321:DNA-Directed RNA Polymerases; D004720:Endonucleases