Molecular biology of Wilms' tumor.
This article reviews recent advances in the molecular biology in cytogenetics of Wilms' tumor. The role of tumor suppressor genes in the development of tumors is reviewed and the mapping and genetic loci associated with Wilms' tumor is elucidated. The identification of the WT1 gene as well as the normal expression of that gene is reviewed. Identification of the putative WT2 gene is also reviewed.
Koo
H P
HP
Department of Urology, Babies Hospital, Columbia-Presbyterian Medical Center, New York, New York.
Hensle
T W
TW
D002648:Child; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D016162:Genes, Wilms Tumor / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D009396:Wilms Tumor / Q000235:genetics*