Effects of unfractionated and low molecular weight heparin on platelet-induced thrombin formation time and platelet adhesion.
Fraxiparin induced a significant inhibition of PITT 3 and 6 hours after the injection, and a nonsignificant moderate 25% prolongation after 9 hours. UFH inhibited PITT significantly 2 and 4 hours after the injection, and after 6 and 8 hours a nonsignificant 15 to 20% prolongation was observed. In hirudinized blood platelet adhesion was significantly prolonged 3 and 12 hours after the injection of Fraxiparin. If citrated blood was used to measure platelet adhesion a significant decrease was observed 3 to 18 hours after the Fraxiparin injection. UFH significantly inhibited platelet adhesion up to 8 hours after the injection. The long duration of the inhibition of platelet adhesion may possibly be correlated with the antithrombotic effect of heparin.
Department of Internal Medicine, J.W. Goethe-University, Frankfurt am Main, Germany.
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Basic-Micic
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Breddin
D000328:Adult; D000925:Anticoagulants / Q000494:pharmacology; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects*; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006629:Hirudins / Q000494:pharmacology; D006801:Humans; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013917:Thrombin / Q000096:biosynthesis*
D000925:Anticoagulants; D002951:Citrates; D006495:Heparin, Low-Molecular-Weight; D006629:Hirudins; D010975:Platelet Aggregation Inhibitors; D019343:Citric Acid; D006493:Heparin; D013917:Thrombin