Hematogenous endophthalmitis due to Candida tropicalis: report of two cases and review.
Candida tropicalis is a well-documented pathogen affecting humans. There is limited clinical and experimental evidence that C. tropicalis causes hematogenous endophthalmitis. We report two cases of C. tropicalis endophthalmitis and review 12 cases reported in the literature. Clinical presentation was similar to that described for Candida albicans endophthalmitis. Therapy with amphotericin B, with or without flucytosine, resulted in resolution of the lesions except in one patient, for whom enucleation of the eye was necessary to control the infection. None of the patients were leukopenic.
Department of Medicine, University of Southern California School of Medicine, Los Angeles.
M
M
Cohen
J Z
JZ
Montgomerie
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001769:Blood / Q000382:microbiology; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged
D000666:Amphotericin B; D005437:Flucytosine