[The postradiation effect of noradrenaline, serotonin and dopamine on the activity of the Na-K pump in rat brain slices].
Whole-body X irradiation with doses of 0.155 and 0.310 C/kg was shown to modify in different ways the activating effects of noradrenaline and serotonin, as well as a biphase effect of dopamine (5.10(-8)--1.5.10(-3) M) on Na,K-pump of neuronal membranes. The resulting effect was a function of a combination of radiation doses and neurotransmitter concentrations and thus showed different modes of interaction between neurotransmitter and ion-transport systems of brain cells in radiation sickness. The authors discuss possible molecular mechanisms of radiation modification of the functional interaction between the neurotransmitter and the active ion-transport systems in nerve cells.
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Dvoretskiĭ
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Kulikova
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects / Q000528:radiation effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D004298:Dopamine / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D009638:Norepinephrine / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000528:radiation effects*; D013997:Time Factors; D014916:Whole-Body Irradiation
D012701:Serotonin; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D004298:Dopamine; D009638:Norepinephrine