2',3'-dideoxyinosine (ddI): its chemical stability and cyclodextrin complexation in aqueous media.
The chemical stability of 2',3'-dideoxyinosine has been studied over a wide pH range (0-12). A stability-indicating HPLC method was used to separate the degradation product from the parent drug. The effects of temperature, ionic strength and buffer components on the degradation kinetics were investigated. Furthermore, the influence of some cyclodextrins (alpha-, beta-, HP-beta-, DM-beta- and gamma-cyclodextrin) on the drug stability have been studied.
Department of Clinical Chemistry, Leyenburg Hospital, The Hague, The Netherlands.
O
O
Bekers
J H
JH
Beijnen
M J
MJ
Tank
D M
DM
Burger
P L
PL
Meenhorst
A J
AJ
Lombarts
W J
WJ
Underberg
D002021:Buffers; D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins / Q000737:chemistry*; D016049:Didanosine / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009994:Osmolar Concentration; D013696:Temperature
D002021:Buffers; D003505:Cyclodextrins; D016049:Didanosine