Possible involvement of cyclic adenosine 3',5'-monophosphate in the regulation of NADP-/NAD-glutamate dehydrogenase ratio and in yeast-mycelium transition of Benjaminiella poitrasii.
The effect of different adenine-containing compounds on the NADP-/NAD-glutamate dehydrogenase (GDH) ratio was studied as a function of yeast-mycelium transition in Benjaminiella poitrasii. Under in vivo conditions, at a 5.0 mM concentration, cyclic AMP (cAMP) and dibutyryl cAMP maintained the cells in the yeast form for up to 7 and 5 h, respectively, and this was reflected in the patterns of GDH ratios observed. In vitro studies of phosphorylation and dephosphorylation have also been carried out, and the results suggest a possible correlation between cAMP, the GDH ratio, and cell form in B. poitrasii.
Biochemical Sciences Division, National Chemical Laboratory, Pune, India.
A
A
Khale-Kumar
M V
MV
Deshpande
D000225:Adenine / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D007700:Kinetics; D009090:Mucorales / Q000201:enzymology* / Q000254:growth & development / Q000648:ultrastructure; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010766:Phosphorylation
D005656:Fungal Proteins; D009243:NAD; D009249:NADP; D000242:Cyclic AMP; D005969:Glutamate Dehydrogenase; D000225:Adenine