Electroencephalographic effects of flucloxacillin in rats.
The neurotoxicity of flucloxacillin, an isoxazolyl derivative of beta-lactamic antibiotics, was studied in rats by electroencephalographic recordings. The results show that intravenous flucloxacillin, (200 mg/kg) produced cortical activity modifications. The changes in electroencephalogram consist of irritative activity patterns and bursts of high voltage waves with spikes and polyspikes. The effects of other beta-lactamic drugs (cloxacillin, ampicillin-sulbactam and penicillin G) on electroencephalography activity were also investigated after intravenous administration of equivalent doses. These drugs did not change the normal bioelectric cerebral activity of the rats.
Contreras
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Department of Pharmacology, School of Medicine, Faculty of Medicine, University of Chile, Santiago.
Kramer
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MV
Pesce
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ME
D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003023:Cloxacillin / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects*; D005436:Floxacillin / Q000494:pharmacology*; D007275:Injections, Intravenous; D010400:Penicillin G / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013407:Sulbactam / Q000494:pharmacology
D005436:Floxacillin; C035444:sultamicillin; D000667:Ampicillin; D003023:Cloxacillin; D010400:Penicillin G; D013407:Sulbactam