Evidence for the phosphorylation of dopamine by striatal tissue from rat brain.
Methods were developed for the chemical phosphorylation of dopamine and for the isolation of phosphorylated dopamine from acidic extracts of rat brain. The developed methods were applied to provide evidence that striatal tissue from rat brain can phosphorylate dopamine to yield dopamine-3-monophosphate ester and dopamine-4-monophosphate ester.
Department of Pharmacology, University of Missouri-Columbia School of Medicine 65212.
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Byington
D000818:Animals; D001923:Brain Chemistry; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D008297:Male; D010472:Perchlorates; D010710:Phosphates / Q000302:isolation & purification / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley
D010472:Perchlorates; D010710:Phosphates; D010761:Phosphorus Radioisotopes; D004298:Dopamine