Epidermal growth factor-like activity and epidermal growth factor-receptors in human primary breast cancer.
Ligands binding to epidermal growth factor-receptors (EGF-Rs) as epidermal growth factor-like activity (EGF-like activity), along with EGF-R levels, were determined from human primary breast cancer samples. Receptor analysis revealed a single class of high affinity binding sites. Ng/mg protein EGF-like activity quantities were measured in cytosols, and were inversely correlated with EGF-R contents (p < 0.01), estimated by two-point assays.
Albert Szent-György Medical University, Department of Radiology, Hungary.
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Kahán
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Szücs
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M
Vecsernyés
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S
Eckhardt
D001943:Breast Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D003600:Cytosol / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000502:physiology*; D066246:ErbB Receptors / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D016211:Transforming Growth Factor alpha / Q000378:metabolism / Q000502:physiology
D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor; D066246:ErbB Receptors