3-Aroylmethyl-2H-1,3-benzoxazinedione derivatives with anticholinergic and antihistaminic activities.
The synthesis of new 3-aroylmethyl-2H-1,3-benzoxazinedione derivatives is reported. The structure of these products are supported by their UV, IR and 1H-NMR spectra, as well as by elemental analysis. The new compounds were tested for their anticholinergic and antihistaminic activities.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
H
H
Gülhan Pilli-Ayyildiz
F
F
Ozkanli
E
E
Palaska
C
C
Safak
H
H
Erdogan
K
K
Erol
M
M
Ozdemir
D000818:Animals; D005260:Female; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D007537:Isometric Contraction / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010276:Parasympatholytics / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D006633:Histamine Antagonists; D010078:Oxazines; D010276:Parasympatholytics