Uterine cervical lymphoepithelial-like carcinoma. Absence of Epstein-Barr virus genomes.
A poorly differentiated squamous cell carcinoma of the cervix with marked lymphoplasmacytic stromal infiltration is described in a 21-year-old black woman who had postcoital bleeding. Histologic features were strikingly similar to the classic lymphoepithelioma of the nasopharynx. Serologic evidence for remote Epstein-Barr virus infection was present. However, polymerase chain reaction amplification and hybridization of DNA extracted from fresh-frozen tumor tissue failed to identify Epstein-Barr virus genomic DNA. No human papillomavirus DNA was detected by polymerase chain reaction amplification. The histologic and Epstein-Barr virus results of the uterine cervical lymphoepitheliomal-like carcinoma were compared to the classic nasopharyngeal lymphoepithelioma and to similar tumors studied from other anatomic sites.
Department of Pathology, Albany Medical College, New York 12208.
E
E
Weinberg
S
S
Hoisington
A Y
AY
Eastman
D K
DK
Rice
J
J
Malfetano
J S
JS
Ross
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm; D004279:DNA, Viral