Histamine H3 receptor-mediated modulation of water consumption in the rat.
The effect of the selective H3 receptor agonist (R)-alpha-methylhistamine and antagonist thioperamide on water consumption in the rat were examined. (R)-alpha-Methylhistamine (0.1-20 mg.kg-1 i.p.) evoked a dose-dependent increase in water consumption the maximum effect being 310 +/- 23% (n = 67) above the vehicle control response. Thioperamide (0.2,2 and 10 mg.kg-1 i.p.) alone had no effect on water consumption. However, the stimulatory effect of (R)-alpha-methylhistamine on water consumption was antagonised by thioperamide in a dose-dependent manner, whereas the H1 receptor antagonist mepyramine and the H2 receptor antagonist loxtidine were without effect. It is therefore concluded that the H3 receptor may play a role in the regulation of water consumption in the rat.
Clapham
J
J
Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Herts UK.
Kilpatrick
G J
GJ
D000818:Animals; D004326:Drinking / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology; D009539:Nicotinic Acids / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology*; D018100:Receptors, Histamine H3; D013777:Tetrazoles / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D006633:Histamine Antagonists; D008761:Methylhistamines; D009539:Nicotinic Acids; D010880:Piperidines; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D013777:Tetrazoles; D014230:Triazoles; C078790:GR 117289; C069357:alpha-methylhistamine; C039993:loxtidine; D006632:Histamine; D011738:Pyrilamine; C052075:thioperamide