[The normal characteristics of erythrocyte Na, K-ATPase in rats with different behaviors to ethanol and after chronic alcoholization].
The relationship of Na,K-ATPase of erythrocytes and MgCl2 concentration in the incubation medium was studied in rats preferring ethanol (PE) and rejecting ethanol (RE) normally and 3 months after chronic alcoholization. The dependence of erythrocyte Na,K-ATPase on MgCl2 in PE and RE animals before alcoholization was similar. The chronic effect of alcohol on rats resulted in increase of Na,K-ATPase both in PE and RE rats; however, Mg(2+)-dependence of increase of Na,K-ATPase differed in animals with different response to alcohol: in PE rats, the per cent of increasing activity of Na,K-ATPase declined with the growth of MgCl2 concentration and in RE rats increased. It is concluded that the reaction to alcohol of the functional activity of plasma membranes differs in rats with different alcohol motivation.
Savonenko
A V
AV
Prokop'eva
V D
VD
D000428:Alcohol Drinking / Q000097:blood*; D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D015636:Magnesium Chloride / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood* / Q000187:drug effects; D013997:Time Factors
D015636:Magnesium Chloride; D000254:Sodium-Potassium-Exchanging ATPase