Prospective study on efficacy and tolerability of solvent/detergent-treated plasma in intensive care unit patients.
Thirty patients who were postoperatively admitted to the intensive care unit had to be treated because of disseminated intravascular coagulation and/or coagulopathy resulting from blood volume dilution or loss. These patients received a single dose of solvent/detergent-treated plasma (Octaplas). No other blood products were administered 6 h prior to and 1 h after completion of the plasma infusion. Coagulation analyses were performed before and 10-60 min after plasma administration. Prothrombin time, fibrinogen, antithrombin III, and systolic blood pressure improved significantly due to plasma therapy. Activated partial thromboplastin time and platelet count also improved, but the differences were not significant. During the observation period, no side effects occurred. The subjectively assessed hemostatic effect was good.
Institut für Transfusionsmedizin und Immunhämatologie, Klinikum Ludwigshafen, Rhein, BRD.
P
P
Hellstern
E
E
Larbig
G A
GA
Walz
W
W
Thürigen
K
K
Oberfrank
D000368:Aged; D000998:Antiviral Agents; D016063:Blood Loss, Surgical / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D003902:Detergents; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000628:therapy*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D017830:Octoxynol; D010755:Organophosphates; D010949:Plasma / Q000382:microbiology; D011092:Polyethylene Glycols; D011183:Postoperative Complications / Q000097:blood / Q000628:therapy*; D011446:Prospective Studies; D012997:Solvents
D000998:Antiviral Agents; D003902:Detergents; D010755:Organophosphates; D012997:Solvents; D011092:Polyethylene Glycols; D017830:Octoxynol; C009524:tributyl phosphate