Structure-activity relationships of [Nle4, D-Phe7]alpha-MSH. Discovery of a tripeptidyl agonist exhibiting sustained bioactivity.
Sawyer
T K
TK
Upjohn Company, Kalamazoo, Michigan 49001.
Castrucci
A M
AM
Staples
D J
DJ
Affholter
J A
JA
De Vaux
A
A
Hruby
V J
VJ
Hadley
M E
ME
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D008116:Lizards; D009074:Melanocyte-Stimulating Hormones / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology; D011894:Rana pipiens; D012867:Skin / Q000187:drug effects*; D013329:Structure-Activity Relationship; D000521:alpha-MSH / Q000031:analogs & derivatives* / Q000494:pharmacology*
D010446:Peptide Fragments; D000521:alpha-MSH; C027756:MSH, 4-Nle-7-Phe-alpha-; D009074:Melanocyte-Stimulating Hormones