A computer model of the convulsive membrane.
A computer model of the convulsive membrane was built up by combining the H-H equations of normal ionic currents with a pathological current flowing through calcium channels and carrying sodium ions. Thus any form of paroxysmal depolarization shift could be simulated, by varying two rate constants and potassium conductance. The simulated PDSs are initiated by a minimal conductance pulse and terminate spontaneously according to the inherent rules of the model system. The program is written in Turbo-Pascal language and can be run on any PC.
Department of Comparative Physiology, Attila József University, Szeged, Hungary.
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Fehér
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Simigla
D015220:Calcium Channels / Q000502:physiology; D003198:Computer Simulation; D004558:Electric Stimulation; D007700:Kinetics; D008564:Membrane Potentials / Q000502:physiology; D008566:Membranes / Q000737:chemistry / Q000503:physiopathology; D008959:Models, Neurological; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology; D012640:Seizures / Q000503:physiopathology*; D015222:Sodium Channels / Q000502:physiology
D015220:Calcium Channels; D015221:Potassium Channels; D015222:Sodium Channels