Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions.
To determine the relationship of human herpesvirus-6 (HHV-6) infection to febrile convulsions, cerebrospinal fluid (CSF) from patients with a history of febrile convulsion were tested by polymerase chain reaction (PCR) amplification for HHV-6 DNA. HHV-6 DNA was detected in 9 of 10 samples from patients with exanthem subitum who showed neurologic symptoms. Also, 8 of 10 CSF samples from 8 patients who had three or more febrile convulsions and 1 of 7 CSF samples from patients who had a single febrile convulsion contained HHV-6 DNA. These data suggest that HHV-6 may invade the brain during the acute phase of exanthem subitum and that recurrence of febrile convulsions may be associated with reactivation of HHV-6.
Department of Virology, Osaka University, Japan.
K
K
Kondo
H
H
Nagafuji
A
A
Hata
C
C
Tomomori
K
K
Yamanishi
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D002490:Central Nervous System / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005077:Exanthema Subitum / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology; D005260:Female; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D012008:Recurrence; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology
D004279:DNA, Viral