Ontogenic activities and interactions of the lactate dehydrogenase isozymes with cellular structure in the guinea pig.
The LDH activities and isozyme distributions associated with soluble and particulate fractions of five major tissues have been followed during the development of the guinea pig. Evidence has been provided for an appreciable degree of interaction between LDH and cellular structure in all these tissues (liver, kidney, skeletal muscle, brain and heart) at all stages of development, but particularly in the early foetal stages. These data have been discussed in relation to the nature and extent of this binding and the correlations with the metabolic emphases in these tissue situations during development.
Division of Science and Technology, Griffith University, Brisbane, Australia.
W
W
Murrell
D
D
Crane
C
C
Masters
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000254:growth & development; D006128:Growth / Q000502:physiology*; D006168:Guinea Pigs; D006321:Heart / Q000254:growth & development; D007527:Isoenzymes; D007668:Kidney / Q000201:enzymology / Q000254:growth & development; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000254:growth & development; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D012995:Solubility; D014018:Tissue Distribution
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase