Mandibular osteomas in sporadic colorectal carcinoma. A genetic marker.
Pantomography of the mandible was performed in 98 patients with sporadic colorectal adenocarcinoma. Twenty-eight patients (29%) had osteomas versus 5% in a control group (P < 0.001). Mandibular osteomas are found in most patients with the premalignant dominant syndrome familial adenomatous polyposis. Sporadic colorectal cancer examinations of married couples have shown that diet has only a moderate influence on the development of colorectal cancer, whereas pedigree studies indicate a genetic component. On this basis we conclude that mandibular osteomas are probably genetic markers of the development of sporadic colorectal carcinoma.
Søndergaard
J O
JO
Dept. of Surgical Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark.
Rasmussen
M S
MS
Videbaek
H
H
Bernstein
I T
IT
Myrhøj
T
T
Kristiansen
V B
VB
Sommer
P
P
Bülow
S
S
D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics*; D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000235:genetics*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000235:genetics*; D010016:Osteoma / Q000235:genetics*
D005819:Genetic Markers