Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration.
Serum creatinine and drug concentrations were measured at 0, 1, 2, 3, 6, 9 and 12 months in 30 consecutive patients started on amiodarone. In 28 of these patients with no obvious cause for altered renal function, mean serum creatinine increased to 11% above baseline (P < 0.005). Rising creatinine concentrations correlated with amiodarone concentrations (y = 93.9 + 8.6x, r = 0.51, P < 0.0001). When assessing elevation of serum creatinine in a patient receiving amiodarone, physicians should be aware that it may be related to this drug.
Pollak
P T
PT
Department of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada.
Sharma
A D
AD
Carruthers
S G
SG
D000638:Amiodarone / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D003404:Creatinine; D000638:Amiodarone