New developments in Sjögren's syndrome.
The growing number of conditions associated with sicca manifestations and focal sialadenitis has shed further light on the heterogeneity of Sjögren's syndrome. Viral and retroviral infections, lymphoproliferative disorders, as well as various autoimmune syndromes, target the lacrimal and salivary glands and incite a local immune response. This awareness has not only intensified the search for a viral or retroviral cause of Sjögren's syndrome, but it has also provided a daunting challenge to investigators who are striving to improve diagnostic testing and classification. A better understanding of Sjögren's syndrome is needed to develop innovative and more effective therapies.
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
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St Clair
D001323:Autoantibodies; D001402:B-Lymphocytes / Q000276:immunology; D015673:Fatigue Syndrome, Chronic / Q000150:complications; D005802:Genes, MHC Class II; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D009103:Multiple Sclerosis / Q000150:complications; D009395:Nephritis, Interstitial / Q000209:etiology / Q000473:pathology; D012137:Respiratory System / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications / Q000209:etiology / Q000473:pathology; D014780:Viruses
D001323:Autoantibodies