Sodium transport in hypertension: assessment of membrane-associated defects in South African black and white hypertensives.
Sodium transport was studied in red cells taken from four groups of patients, whites or blacks, and normotensive or hypertensive, with approximately ten patients in each group. There were no differences between normotensive and hypertensive whites. Normotensive blacks had higher rates of sodium-proton exchange than did the other groups, and hypertensive blacks had higher rates of efflux via the sodium-potassium ATPase than did other groups. These data support proposals that hypertension in black subjects is linked to abnormalities of control of intracellular sodium.
Worthington
M G
MG
Ischaemic Heart Disease Research Unit of the Medical Research Council, Cape Town, South Africa.
Wendt
M C
MC
Opie
L H
LH
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000375:Aging / Q000378:metabolism; D000428:Alcohol Drinking / Q000097:blood; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044383:Black People; D002352:Carrier Proteins / Q000378:metabolism; D004573:Electrolytes / Q000097:blood; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects; D012964:Sodium / Q000097:blood*; D017923:Sodium-Hydrogen Exchangers; D028021:Sodium-Potassium-Chloride Symporters; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000502:physiology; D013019:South Africa; D044465:White People
D000959:Antihypertensive Agents; D002352:Carrier Proteins; D004573:Electrolytes; D017923:Sodium-Hydrogen Exchangers; D028021:Sodium-Potassium-Chloride Symporters; D005665:Furosemide; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase