Biosynthesis of polyesters from various amino acids by Alcaligenes eutrophus.
The possibilities of the biosynthesis of polyesters from 20 kinds of naturally occurring L-amino acids by Alcaligenes eutrophus were studied. It was found that several amino acids were used efficiently to synthesize copolyesters of 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3 HV) by A. eutrophus under the 'loose nitrogen-limiting' condition, but the other amino acids were scarcely utilized as a carbon source for the synthesis of polyesters. When L-threonine or L-isoleucine were used as the sole carbon source, copolyesters with higher 3HV content were produced.
Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan.
M
M
Fujita
K
K
Nakamura
H
H
Kuroki
N
N
Yoshie
Y
Y
Inoue
D020155:3-Hydroxybutyric Acid; D000421:Alcaligenes / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D005285:Fermentation; D006885:Hydroxybutyrates / Q000378:metabolism*; D007218:Industrial Microbiology; D008970:Molecular Weight; D009584:Nitrogen / Q000378:metabolism; D010421:Pentanoic Acids / Q000378:metabolism*; D011091:Polyesters / Q000378:metabolism*
D000596:Amino Acids; D006885:Hydroxybutyrates; D010421:Pentanoic Acids; D011091:Polyesters; C013056:beta-hydroxyvaleric acid; D009584:Nitrogen; D020155:3-Hydroxybutyric Acid