[Clinical application of drug delivery system of anti-cancer drugs--the pharmacokinetics and clinical results].
Pharmacokinetic study of anticancer drug is essential for clinical application of cancer chemotherapy. In this paper, the relationship between pharmacokinetics and clinical results was described in addition, the treatment of peritonitis carcinomatosa with mitomycin C adsorbed to activated carbon particles, intraarterial infusion chemotherapy with anticancer drugs suspended in Lipiodol and 5-FU suppository for rectal carcinomas were described. Also monoclonal antibody as a carrier of anticancer drug was mentioned and its problems was discussed from the aspect of pharmacokinetics of antibody-drug conjugate.
First Dept. of Surgery, Kyoto Prefectural University of Medicine, Japan.
T
T
Yamaguchi
A
A
Hagiwara
H
H
Taniguchi
T
T
Takahashi
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use; D007459:Iodized Oil / Q000008:administration & dosage; D016685:Mitomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D012004:Rectal Neoplasms / Q000188:drug therapy; D013488:Suppositories
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D013488:Suppositories; D016685:Mitomycin; D007459:Iodized Oil; D005472:Fluorouracil