Association between Raynaud's phenomenon and migraine in a random population of hospital employees.
OBJECTIVE
To determine the relationship between migraine and Raynaud's phenomenon.


METHODS
A detailed headache questionnaire was completed by 41 subjects with Raynaud's phenomenon identified in a random survey of hospital employees and by a group matched for age and sex without Raynaud's phenomenon.


RESULTS
The prevalence of migraine was increased significantly in the group with Raynaud's phenomenon compared with the control group (24/41, 58.5% vs 10/41, 24.4%; p = 0.002). This result agrees with findings in hospital-based studies of patients with Raynaud's phenomenon.


CONCLUSIONS
The prevalence of migraine is significantly increased in subjects with Raynaud's phenomenon, suggesting that these conditions may share a common pathogenetic defect or mechanism.
O'Keeffe
S T
ST
Section of Vascular Medicine and Hypertension, Lahey Clinic Medical Center, Burlington, MA 01085.
Tsapatsaris
N P
NP
Beetham
W P
WP
D000328:Adult; D005260:Female; D006801:Humans; D008404:Massachusetts; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000453:epidemiology* / Q000209:etiology; D010564:Personnel, Hospital / Q000706:statistics & numerical data*; D015995:Prevalence; D011928:Raynaud Disease / Q000150:complications / Q000453:epidemiology* / Q000209:etiology; D011795:Surveys and Questionnaires