Liposomal amphotericin B bases of therapeutic index increase.
Liposomes represent for amphotericin B (AmB) a promising delivery system that may reduce the important toxicity of the drug. Liposomal AmB has a higher therapeutic index than AmB alone and allows to use larger doses. The mechanism of reduced toxicity may be related to a better targeting ability, a protective effect, and a selective transfer of liposomes. Anyway the liposomes intercalated AmB tends to be uptaken by organs that belong to the reticuloendothelial system, where fungi, the target cells, are localized.
Laboratoire de Physique et Chimie Biomoléculaires, Université Pierre et Marie Curie, Paris.
P
P
Legrand
A
A
Vertut-Doï
J
J
Bolard
D000666:Amphotericin B / Q000008:administration & dosage* / Q000633:toxicity; D000818:Animals; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes
D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B