The influence of ascorbic acid on selected parameters of cell immunity in guinea pigs exposed to cadmium.
The study investigated the possibility of influencing immunotoxic effects of Cd through ascorbic acid. Guinea pigs with high and low intake of ascorbic acid were perorally exposed to cadmium chloride (1 mg Cd/animal/day). The daily vitamin C intake was 2 and 100 mg per animal, respectively. Phagocytic activity of polymorphonuclear leucocytes and monocytes as well as the percentage of active and total T lymphocytes in peripheral blood of animals were evaluated. Five- and 12-week experiments showed a mutual potentiation of negative effects of Cd on the immune system by suboptimal intake of ascorbic acid. Toxic effects of Cd on the immune system can be reduced by a sufficient intake of vitamin C.
Kubová
J
J
Institute of Preventive and Clinical Medicine, Bratislava.
Tulinská
J
J
Stolcová
E
E
Mosat'ová
A
A
Ginter
E
E
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001206:Ascorbic Acid Deficiency / Q000276:immunology; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000517:prevention & control*; D004347:Drug Interactions; D004781:Environmental Exposure; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D002104:Cadmium; D001205:Ascorbic Acid