Oat husk fiber decreases plasminogen activator inhibitor type 1 activity.
Eleven healthy subjects volunteered to participate in a fiber supplement study and were instructed to consume oat husk tablets in addition to their regular diets. During a 2-week experimental period the subjects consumed 10 g oat husk per day. Blood samples were collected before breakfast between 8:00 and 9:00. As compared to baseline, 10 g oat husk supplementation per day resulted in a reduction of plasma plasminogen activator inhibitor type 1 (PAI-1) activity (p < 0.05). Except for an increase in glucose, no other statistically significant deviation from baseline was observed in measured blood parameters; tissue plasminogen activator activity, prourinary plasminogen activator, coagulation factor VII, total cholesterol, HDL cholesterol, LDL cholesterol, lipoprotein (a), triglycerides and insulin. A 6-week washout period returned the PAI-1 activity level to baseline.
Department of Pathology, Umeå University, Sweden.
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D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003864:Depression, Chemical; D004043:Dietary Fiber / Q000008:administration & dosage / Q000494:pharmacology*; D002523:Edible Grain; D005167:Factor VII / Q000032:analysis; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D013607:Tablets; D014280:Triglycerides / Q000097:blood; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin; D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; D013607:Tablets; D014280:Triglycerides; D005167:Factor VII; D002784:Cholesterol; D014568:Urokinase-Type Plasminogen Activator