Spontaneous ovarian choriocarcinoma, yolk sac carcinoma, and teratoma in B6C3F1 mice: a case report.
Three ovarian neoplasms (choriocarcinoma, yolk sac carcinoma, and teratoma) were diagnosed in a 2 yr carcinogenicity study involving B6C3F1 mice. The yolk sac carcinoma and the teratoma occurred in opposite ovaries of a single female mouse that was sacrificed in extremis on study day 725. The choriocarcinoma occurred in a female mouse that was sacrificed in extremis on study day 565. These neoplasms were considered to be spontaneous in origin.
Frith
C H
CH
Toxicology Pathology Associates, Little Rock, Arkansas 72211.
Evans
M G
MG
D000818:Animals; D002822:Choriocarcinoma / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D008649:Mesonephroma / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D010048:Ovarian Cysts / Q000473:pathology; D010049:Ovarian Diseases / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*