Peptidoglycan synthesis in Salmonella typhimurium 2616.
HPLC analysis of peptidoglycan synthesis in Salmonella typhimurium strain 2616 has revealed that: (i) there is observable variation in the composition, but no significant variation in the overall degree of cross-linking, of newly synthesized peptidoglycan during the division cycle; (ii) the types of muropeptide that constitute peptidoglycan do not vary over a wide range of growth rates; and (iii) the composition and maturation kinetics of S. typhimurium peptidoglycan are, as expected, similar to those of Escherichia coli. We propose a unitary model of peptidoglycan synthesis, with single-strand incorporation occurring at both side wall and polar sites.
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620.
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D002455:Cell Division; D008954:Models, Biological; D010457:Peptidoglycan / Q000096:biosynthesis* / Q000737:chemistry; D012486:Salmonella typhimurium / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors
D010457:Peptidoglycan