Antithrombotic effect and reperfusion by low molecular weight heparin in a canine model of coronary artery thrombosis.
The lability of an intracoronary thrombus, which is common in the case of unstable angina, indicates the presence of endogenous fibrinolysis. To prove our hypothesis that suppression of coagulation facilitates the thrombolytic process, low molecular weight heparin (LMWH) was given intravenously to dogs with intracoronary thrombi induced by copper coils. LMWH caused reperfusion in this model and suppressed the formation of intracoronary thrombi, thus supporting our hypothesis.
Viigimaa
M
M
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Ohnogi
H
H
Hattori
R
R
Yui
Y
Y
Kawai
C
C
D000818:Animals; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000188:drug therapy* / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D015424:Reperfusion
D006495:Heparin, Low-Molecular-Weight