Neomycin toxicity in bladder irrigation.
Neomycin is known for its ototoxicity after many different methods of administration of the drug. Neomycin sometimes is used for bladder irrigation in patients with urinary tract infections when other treatments fail. To our knowledge toxicity after bladder instillation of neomycin has not been reported previously. We report a case of perception deafness in a boy with end stage renal disease who underwent neomycin bladder instillations following augmentation of the bladder with a megaureter.
Pediatric Renal Center, University Hospital for Children and Youth, Utrecht, The Netherlands.
T P
TP
de Jong
R A
RA
Donckerwolcke
T M
TM
Boemers
D000283:Administration, Intravesical; D002675:Child, Preschool; D003638:Deafness / Q000139:chemically induced*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D009355:Neomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007507:Therapeutic Irrigation; D001743:Urinary Bladder / Q000187:drug effects / Q000601:surgery; D014552:Urinary Tract Infections / Q000188:drug therapy*
D009355:Neomycin