The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution in Coronaviridae.
The nucleoprotein-encoding gene (N) of murine hepatitis virus type 3 (MHV 3), from the Mill Hill strain, was cloned and sequenced. It was compared to gene N from other murine coronaviruses and was found to share more similarities with N sequences from MHV 1 and MHV JHM strains than with the published MHV 3 N sequence which is almost identical to MHV A59. We suggest that the evolution of some MHV N sequences resulted from a double recombination phenomenon between two ancestors. Furthermore, comparison of protein N from avian and mammalian coronaviruses leads to the hypothesis that horizontal transfer events of the virus from one host species to another have occurred.
INSERM Unité 347 affiliée au CNRS, Université Paris XI, Hôpital de Kremlin-Bicêtre, France.
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Décimo
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Philippe
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Hadchouel
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Tardieu
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Meunier-Rotival
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D001717:Birds; D002213:Capsid / Q000737:chemistry / Q000235:genetics*; D003332:Coronaviridae / Q000235:genetics*; D008322:Mammals; D008969:Molecular Sequence Data; D006517:Murine hepatitis virus / Q000235:genetics*; D016366:Open Reading Frames; D011995:Recombination, Genetic; D014758:Viral Core Proteins / Q000737:chemistry / Q000235:genetics*
D014758:Viral Core Proteins