[Anticancer agents targeting oncogene products].
Accumulating evidence indicates that the activation of cellular oncogenes is a cause of some human cancers. ErbB-1, erbB-2 and abl oncogenes encoding tyrosine kinases, ras oncogenes encoding GTP binding proteins and myc oncogenes whose functions are not well understood are some examples. Therefore, agents which inhibit the activity of these oncogene products may provide new means to overcome certain human tumors. Herbimycin A and tyrphostins have been found and developed as inhibitors of tyrosine kinases and the effectiveness of these agents against tumors of Ph1-positive leukemia (CML, ALL) or squamous cell carcinomas has been reported. Although specific inhibitors of ras or myc oncogene products have not yet been described, recent studies on the processing of Ras proteins toward the cell membrane provide a strategy to search for inhibitors of ras functions.
National Institute of Health, Tokyo, Japan.
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Uehara
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D016227:Benzoquinones; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology; D019938:Cyclin D1; D005260:Female; D011905:Genes, ras; D006801:Humans; D047029:Lactams, Macrocyclic; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*; D017828:Rifabutin / Q000031:analogs & derivatives; D020032:Tyrphostins
D000903:Antibiotics, Antineoplastic; D016227:Benzoquinones; D002396:Catechols; D047029:Lactams, Macrocyclic; D009570:Nitriles; D011518:Proto-Oncogene Proteins; D011809:Quinones; D020032:Tyrphostins; C060152:tyrphostin 47; D019938:Cyclin D1; D017828:Rifabutin; C020754:herbimycin; D011505:Protein-Tyrosine Kinases