Immune responses to varicella zoster virus infections in healthy children.
The immune responses to varicella zoster virus were studied in 67 otherwise normal children participating in a placebo-controlled trial of acyclovir for the treatment of chickenpox. No differences were observed between acyclovir and placebo groups. Children were studied longitudinally, at onset of chickenpox, and at 1 month, 3 months, 1 year, and 3 years after infection. These data help define the natural history of the immune response to chickenpox in children.
Department of Pediatrics (Section of Infectious Diseases), University of Colorado School of Medicine, Denver 80262.
H A
HA
Rotbart
M J
MJ
Levin
A R
AR
Hayward
D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002644:Chickenpox / Q000188:drug therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D007371:Interferon-gamma; D000212:Acyclovir