Cytokine receptor signal transduction mechanisms in immuno-hematopoietic cells.
Novel aspects of cytokine receptor signal transduction are discussed and cytokine receptors classified based on ligand-dependent signalling. An introductory section presents an overview of the role of cytokines in hematopoiesis. A brief explanation of basic concepts, such as redundancy, pleiotropy, synergism, etc., important for the understanding of cell response to cytokines, is also included. Three of five classes of receptors show the involvement of tyrosine kinase activity as the key step in signal transduction. The importance of tyrosine phosphorylation in cellular response to cytokines is pointed out.
Chiarugi
V
V
Laboratory of Molecular Biology, University of Florence.
Dello Sbarba
P
P
Magnelli
L
L
Chiarugi
P
P
Pacini
S
S
Ruggiero
M
M
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006410:Hematopoiesis; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000166:cytology*; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000145:classification / Q000502:physiology*; D017472:Receptors, Interleukin-1 / Q000502:physiology; D015398:Signal Transduction
D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors; D011956:Receptors, Cell Surface; D017472:Receptors, Interleukin-1; D011505:Protein-Tyrosine Kinases