[The effect of stretching on the cell proliferation of the guinea pig vas deferens in organotypic culture].
Explants of guinea pig vas deferens with longitudinal and transversal stretching were cultivated under organotypic conditions. The longitudinal periodical stretching diminished the initial rise in proliferation of smooth muscle cells from the longitudinal muscular layer but not from the circular one. The continuous transversal stretching decreased proliferation of smooth muscle cells from the circular muscular layer at the onset of cultivation but had no effect on proliferation of smooth muscle cells from the longitudinal layer. Stimulation of the contractile activity by means of stretching decreased proliferation of smooth muscle cells. The longitudinal and transversal stretching authentically decreased proliferation of adventitial cells and increased proliferation of the epithelial cells of the mucosal layer.
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Nizamov
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Kalakov
D000818:Animals; D002455:Cell Division; D046508:Culture Techniques; D006168:Guinea Pigs; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000166:cytology* / Q000502:physiology; D013997:Time Factors; D014649:Vas Deferens / Q000166:cytology / Q000502:physiology