[Possible involvement of a recently discovered human retrovirus in idiopathic immunologic disorders, including Sjögren syndrome (autoimmune exocrinopathy)].
Recent studies have suggested that newly-discovered human retroviruses may contribute to the pathogenesis of several immunological diseases. We linked a human intracisternal A-type retroviral particle (HIAP) to systemic autoimmune diseases, such as Sjögren's Syndrome. A-type retroviruses are envelope-deficient, a property that may contribute to their pathobiology and epidemiology. Potential mechanisms by which a defective retrovirus could induce immune dysfunctions are discussed.
Fermin
C D
CD
Department of Pathology, Tulane University School of Medicine, New Orleans, Louisiana.
Garry
R F
RF
D001327:Autoimmune Diseases / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008854:Microscopy, Electron; D012190:Retroviridae / Q000472:pathogenicity*; D012192:Retroviridae Infections / Q000276:immunology / Q000382:microbiology*; D012469:Salivary Glands / Q000382:microbiology; D012859:Sjogren's Syndrome / Q000276:immunology / Q000382:microbiology*; D014617:Vacuoles / Q000648:ultrastructure; D014774:Virulence