Molecular and cell biology of addiction.
Progress was made during the past year in several important areas relevant to cellular and molecular research on addiction. This includes a better understanding of the functioning of neural circuitry involved in the reinforcing properties of drugs of abuse, the cloning of complementary DNA's encoding important molecular targets of addictive drugs, including the first opiate receptors to be cloned, and progress in understanding the molecular basis of adaptive processes underlying dependence and withdrawal.
Hyman
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Massachusetts General Hospital, Boston.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D009042:Motivation; D009473:Neuronal Plasticity / Q000187:drug effects / Q000235:genetics; D011619:Psychotropic Drugs / Q000494:pharmacology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D013375:Substance Withdrawal Syndrome / Q000235:genetics* / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000235:genetics* / Q000503:physiopathology
D018076:DNA, Complementary; D011619:Psychotropic Drugs; D017981:Receptors, Neurotransmitter