Is pure red cell aplasia (PRCA) a clonal disorder?
Pure red cell aplasia (PRCA) is an uncommon disorder, many cases lacking a well defined aetiology. This report describes three cases of PRCA (two idiopathic and one associated with B-CLL) who were investigated to assess the possibility of their PRCA being associated with a clonal proliferation of T-lymphocytes. The results show that one patient had evidence of T-cell receptor (TCR) gamma chain rearrangement, and the other had a TCR delta chain rearrangement. These two cases raise the possibility of PRCA being associated with a clonal proliferation of T-cells and further studies are warranted.
Department of Molecular Haematology, Leeds General Infirmary, UK.
M
M
Sivakumaran
M
M
Bhavnani
A
A
Stewart
B E
BE
Roberts
G C
GC
Geary
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002999:Clone Cells / Q000473:pathology*; D005260:Female; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000473:pathology*; D016176:T-Lymphocyte Subsets / Q000473:pathology*