Comparative susceptibility profile of piperacillin/tazobactam against anaerobic bacteria.
Current data are summarized on the comparative susceptibility of Gram-positive and Gram-negative anaerobic bacteria to piperacillin/tazobactam and other anti-anaerobe agents. For beta-lactamase-positive organisms, tazobactam, in fixed concentration or fixed ratio, lowered the MIC of piperacillin at least four-fold to susceptible levels in almost all cases; beta-lactamase-negative strains were all susceptible to piperacillin alone. Susceptibility rates and MIC90 values for piperacillin/tazobactam were comparable to those of other anti-anaerobe agents, including other combinations of beta-lactam agents with beta-lactamase inhibitors, such as amoxycillin/clavulanate, ticarcillin/clavulanate, ampicillin/sulbactam and cefoperazone/sulbactam. Kinetic studies revealed IC50 and Ki values for tazobactam that were in most cases lower than those of clavulanate and sulbactam against beta-lactamase-positive Gram-negative anaerobic bacilli.
Department of Pathology (Clinical Microbiology), Hershey Medical Center, PA 17033.
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Appelbaum
D000818:Animals; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin