[The possible approaches to the theoretical validation of the use of cytostatics and corticosteroids in treating glomerulonephritis].
Cyclophosphamide (CP) and methylprednisolone (MP) were tried on rats with experimental nephrotoxic serum nephritis and mice with experimental acute serum nephritis. Pathological processes were analyzed simultaneously in vivo and in vitro. CP reduced the antibody impairment and stimulated glomerular infiltration by mononuclear leukocytes whose mediator spectrum was oriented to repair. MP failed to stop the impairment and aggravated the infiltration. The resultant chaotic accumulation of the extracellular matrix raised the risk of sclerosis. CP showed the advantages in experiment demonstrable also in the clinical setting.
Ivanov
A A
AA
Shilov
E M
EM
Gladskikh
O P
OP
Krasnova
T N
TN
Karpukhin
V V
VV
Gitel'
E P
EP
Pal'tsev
M A
MA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage; D051379:Mice; D008810:Mice, Inbred C57BL; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone