Biochemical model reactions on the prooxidative activity of homocysteine.
The sulfur amino acid homocysteine has recently been addressed as marker for vessel damaging and atherosclerotic dispositions. The atherogenic index has been correlated with the one of cholesterol and is significantly higher in cholesterinemic as compared to normal lipidemic persons. In the present communication biochemical model reactions are presented indicating the prooxidative activity of homocysteine where a cooperative effect with the transition-metals copper and iron is indicated.
Preibisch
G
G
Institut für Botanik und Mikrobiologie, Technische Universität München, Bundesrepublik Deutschland.
Küffner
C
C
Elstner
E F
EF
D003300:Copper / Q000494:pharmacology; D003545:Cysteine / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology; D006461:Hemolysis / Q000187:drug effects*; D006710:Homocysteine / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007501:Iron / Q000494:pharmacology; D007700:Kinetics; D008715:Methionine / Q000031:analogs & derivatives / Q000737:chemistry; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D006710:Homocysteine; C014632:2-keto-4-methylthiobutyric acid; D003300:Copper; D008715:Methionine; D007501:Iron; D000254:Sodium-Potassium-Exchanging ATPase; D003545:Cysteine