[Deletion-insertion polymorphism in the V-region of mitochondrial DNA in ten Mongoloid populations of Siberia, Frequency of deletion correlates with the geographic coordinates of the locality].
Deletion-insertion polymorphism in the V-region of mitochondrial DNA was analysed in ten mongoloid populations of Siberia. Frequencies of 9-bp deletion and 4-bp insertion in the populations were: 7.7 and 1.5% in Buryats; 10.2 and 0.8% in north Altais: 1.4 and 0.0% in Nanays; 1.5 and 0.0% in eastern Evenks; no deletions and insertions of such type were revealed in western Evenks, and also in Mansi, Yakuts, Chukcha and Eskimos. Correlation analysis of the data about the populations from Siberia, foreign Asia and Oceania revealed a geographical gradient of the deletion frequency which increases towards the East. The azimuth of the deletion frequency geographical gradient direction is 170 degrees. The deletion frequency gradient (Z) within the limits from the subarctic regions of Siberia to the west regions of Oceania is described quite completely with the multiple regression equation: Z = 30.516 - 0.840 (latitude) + 0.145 (longitude). The part of geographical factor within the total variability of the deletion frequency is 64%. The regularity discovered does not extend to the indian population of America.
V N
VN
Petrishchev
A B
AB
Kutueva
Iu G
IuG
Rychkov
D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D004251:DNA Transposable Elements; D004272:DNA, Mitochondrial; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012800:Siberia / Q000453:epidemiology
D004251:DNA Transposable Elements; D004272:DNA, Mitochondrial