Human foamy virus polypeptides: identification of env and bel gene products.
Human foamy virus (HFV) proteins were identified in human cells cultured in vitro by immunoprecipitation and immunoblotting with specific antisera. Among several viral polypeptides, four glycoproteins of approximately 160, 130, 70, and 48 kDa were identified in HFV-infected cells. gp130 was shown to represent the intracellular env precursor, and gp70 and gp48 were shown to represent the external and transmembrane env proteins, respectively. The nature of gp160, which shares sequences with the env, bel1, and bel2 proteins, is not yet resolved. In addition, a p62 identified with bel1- and bel2-specific antisera likely corresponds to the bet gene product.
UPR A0043 CNRS Rétrovirus et Rétrotransposons des Vertébrés, Hôpital Saint-Louis, Paris, France.
M L
ML
Giron
F
F
Rozain
M C
MC
Debons-Guillemin
M
M
Canivet
J
J
Peries
R
R
Emanoil-Ravier
D000914:Antibodies, Viral; D015153:Blotting, Western; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000302:isolation & purification*; D015686:Gene Products, env / Q000302:isolation & purification*; D005814:Genes, Viral; D006801:Humans; D012191:Retroviridae Proteins / Q000302:isolation & purification*; D016092:Spumavirus / Q000737:chemistry*; D015534:Trans-Activators / Q000302:isolation & purification*
D000914:Antibodies, Viral; D004268:DNA-Binding Proteins; D015686:Gene Products, env; D012191:Retroviridae Proteins; D015534:Trans-Activators; C074061:bel1 protein, Human foamy virus