Replication-defective recombinant adenovirus expressing the Epstein-Barr virus (EBV) envelope glycoprotein gp340/220 induces protective immunity against EBV-induced lymphomas in the cottontop tamarin.
A replication-defective recombinant adenovirus (Ad) expressing the full length Epstein-Barr virus (EBV) major envelope glycoprotein gp340/220 was tested for its ability to protect against EBV-induced lymphoma in the cottontop tamarin. Antibody responses against Ad capsid proteins and EBV gp340/220 were observed but these antibodies did not neutralize EBV in vitro. However, all immunized animals were protected against challenge following three intramuscular doses of the recombinant Ad. These data indicate that the recombinant Ad is potentially a useful vector for vaccination.
Laboratoire de Génétique des Virus Oncogènes-CNRS UA 1301, Institut Gustave Roussy, Villejuif, France.
T
T
Ragot
S
S
Finerty
P E
PE
Watkins
M
M
Perricaudet
A J
AJ
Morgan
D000256:Adenoviridae; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000096:biosynthesis / Q000276:immunology*; D005822:Genetic Vectors; D004854:Herpesvirus 4, Human / Q000276:immunology*; D008223:Lymphoma / Q000382:microbiology / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000276:immunology; D012452:Saguinus; D014412:Tumor Virus Infections / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000276:immunology; D014763:Viral Matrix Proteins / Q000096:biosynthesis / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology; D014779:Virus Replication
D000914:Antibodies, Viral; D000956:Antigens, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D014763:Viral Matrix Proteins; D014765:Viral Vaccines