Ultrastructural pathology of eccrine sweat gland epithelial cells in globoid cell leukodystrophy.
Three of four children were recognized by deficient beta-galactocerebrosidase activities as having globoid cell leukodystrophy inclusions in sweat gland epithelial cells, similar in ultrastructure to those seen in Schwann cells. This observation in globoid cell leukodystrophy emphasizes the need to include sweat gland epithelial cells in examinations of skin in globoid cell leukodystrophy, as well as in any neurometabolic disorder.
Division of Neuropathology, University of Mainz, Germany.
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Goebel
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Kimura
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Harzer
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Klein
D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004439:Eccrine Glands / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000473:pathology*; D050356:Lipid Metabolism; D008297:Male; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology; D014617:Vacuoles / Q000473:pathology