[The effect of adaptation to repeated stresses on the recovery of cardiac function and creatine phosphate after total ischemia (a 31P-NMR study)].
Adaptation to stress was produced by eight immobilizations of rats for 1 hour every other day. The effects of 25-min ischemia and subsequent 50-min reperfusion on the heart contractile function and energy metabolism were studied. In the adapted rats, the velocities of contraction and relaxation as well as the developed pressure restored during reperfusion much faster than in the controls. The NMR-study showed that a drastic fall of creatine phosphate (CP) and ATP during ischemia was followed by a rapid CP restoration, a Pi drop and a slow ATP restoration during reperfusion. In the adapted animals, the CP restoration was twice as rapid as in the controls. It is obvious that in adaptation to stress the heart function and the system of CP resynthesis appear to be significantly more resistant to ischemia stroke and this is why they restore their activity faster than in the controls.
F Z
FZ
Meerson
L Iu
LIu
Golubeva
V L
VL
Lakomkin
S N
SN
Dvoriantsev
V A
VA
Stepanov
D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D000818:Animals; D006321:Heart / Q000503:physiopathology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D010725:Phosphocreatine / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D010725:Phosphocreatine; D000255:Adenosine Triphosphate