Adaptation of the blood antioxidant defence mechanisms of sheep with a genetic lesion resulting in low red cell glutathione concentrations.
Finnish Landrace sheep with a genetic lesion which results in restricted cysteine transport across the red cell membrane have total glutathione concentrations in their red blood cells that are approximately 40% of those in normal sheep of the same breed. However, dimethyldisulphide-challenged red blood cells from both phenotypes produce an ESR-spin adduct at similar rates. The resistance of the low glutathione phenotype red cells to oxidant challenge is reflected by increases in the activities of antioxidant enzymes. Sheep with a genotypic disorder in cysteine transport may be a suitable model for studying the genetic expression of antioxidant enzymes in response to oxidant loads.
Macaulay Land Use Research Institute, Aberdeen, UK.
D B
DB
McPhail
P C
PC
Morrice
G G
GG
Duthie
D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D004789:Enzyme Activation; D004912:Erythrocytes / Q000201:enzymology* / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D005978:Glutathione / Q000031:analogs & derivatives / Q000097:blood* / Q000172:deficiency* / Q000235:genetics; D019803:Glutathione Disulfide; D010641:Phenotype; D012756:Sheep
D000975:Antioxidants; D005609:Free Radicals; D005978:Glutathione; D019803:Glutathione Disulfide