A cAMP-linked metabotropic glutamate receptor in hippocampus.
Agonists at metabotropic glutamate receptors (mGluR) produce both pre- and postsynaptic responses in the hippocampus that can be monitored electrophysiologically. We provide evidence for the involvement of a distinct mGluR coupled to stimulation of adenosine 3',5'-monophosphate (cAMP) in the postsynaptic actions of 1-aminocyclopentane-trans-1S,3R-dicarboxylic acid (1S,3R-ACPD), a selective mGluR agonist. In contrast, the presynaptic effects of 1S,3R-ACPD are not produced by increases in cAMP, but may be mediated through a different subtype of mGluR linked to inositol phospholipid metabolism.
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada.
J W
JW
Goh
B A
BA
Ballyk
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000187:drug effects*
D017470:Receptors, Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D000242:Cyclic AMP