Tissue tolerance to pelvic intraarterial chemoembolization with cisplatin-lipiodol suspension.
Tissue tolerance to pelvic intraarterial chemoembolization with cisplatin-lipiodol suspension was studied in rabbits. Cisplatin (3 mg/kg) was used with different doses of lipiodol (0.0, 0.1, 0.2, and 0.3 ml/kg). Cisplatin-lipiodol suspension was injected into the umbilical artery through a long polyethylene catheter. Local tissue concentration of platinum was increased with lipiodol, while that in the liver, heart, and kidneys was reduced. Tissue retention of platinum was linearly related to the dosage of lipiodol. With a single dose of 0.2 ml/kg lipiodol, only slight degeneration and sparse hemorrhage were observed without necrosis.
Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, People's Republic of China.
J
J
Li
Y N
YN
Zhao
Z J
ZJ
Miao
L
L
Zhu
Z M
ZM
Wang
H Y
HY
Qin
J H
JH
Xi
D000818:Animals; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004338:Drug Combinations; D005260:Female; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D010388:Pelvis / Q000098:blood supply* / Q000473:pathology; D010984:Platinum / Q000493:pharmacokinetics; D011817:Rabbits; D013535:Suspensions
D004338:Drug Combinations; D013535:Suspensions; D010984:Platinum; D007459:Iodized Oil; D002945:Cisplatin