[The effect of monoclonal antibodies on evoked potentials and on the development of long-term posttetanic potentiation of the hippocampus].
A panel of hybridoma clones producing monoclonal antibodies (Mabs) to the antigens of synaptosomes from rat brain cortex was generated. In immunocytochemical experiments 5F5-B6 Mabs stained stratum moleculare in hippocampus and cerebellum of adult rats intraventricular introduction of 5F5-B6 Mabs was shown to block LTP formation in fascia dentata and to change the evoked potential and population spike amplitude.
T M
TM
Pankova
M V
MV
Starosatina
P N
PN
Liuboslavskaia
V I
VI
Khichenko
M B
MB
Shtark
D000818:Animals; D000911:Antibodies, Monoclonal / Q000302:isolation & purification / Q000494:pharmacology*; D015415:Biomarkers; D002540:Cerebral Cortex / Q000276:immunology; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects / Q000276:immunology; D006624:Hippocampus / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006825:Hybridomas / Q000276:immunology; D007114:Immunization; D007150:Immunohistochemistry; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000276:immunology
D000911:Antibodies, Monoclonal; D015415:Biomarkers