title: The effects of obstruction and secretory stimulation on microlithiasis in salivary glands of cat: light and electron microscopy.
abstract: Obstruction and increased secretory activity are considered to be important aetiological factors of salivary microlithiasis, which may itself be an aetiological factor of sialadenitis. However, there is a lack of substantial evidence for the importance of obstruction, and investigations on increased secretory activity used pathological doses of pharmacological agents. Therefore further investigation of these factors is essential. Feline parotid, submandibular and sublingual salivary glands, in which microliths occur normally as in man, were examined after ductal ligation to produce obstruction, electrical stimulation of the glandular nerves to produce increased secretory activity, or both. Microliths were detected in: 0 out of 38 untreated, 1 out of 55 ligated, 2 out of 17 stimulated and 2 out of 17 stimulated ligated submandibular glands; 6 out of 29 untreated, 7 out of 46 ligated, 3 out of 12 stimulated and 4 out of 14 stimulated ligated sublingual glands; and no parotid glands. The chi 2 test confirmed that the experimental procedures did not produce an increased occurrence of microliths. Microliths were detected in parenchymal cells, intercellularly in atrophic parenchyma, intraluminally, interstitially and in macrophages. The present investigation indicates that obstruction and increased secretory activity are not important aetiological factors of salivary microlithiasis.
authors.affiliation: Department of Oral Pathology, Rayne Institute, King's College School of Medicine and Dentistry, London, England.
authors.forename: J D
authors.initials: JD
authors.lastname: Harrison
authors.forename: A
authors.initials: A
authors.lastname: Triantafyllou
authors.forename: J R
authors.initials: JR
authors.lastname: Garrett
mesh_terms: D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D008026:Ligation; D008853:Microscopy; D008854:Microscopy, Electron; D015494:Salivary Gland Calculi / Q000209:etiology / Q000473:pathology*; D012636:Secretory Rate / Q000502:physiology