title: Growth regulation and transformation of ovarian epithelium.
abstract: The discovery of peptide growth factors and cancer-causing genes (oncogenes and tumor-suppressor genes) has provided us with the exciting opportunity to begin to understand the molecular pathology of human ovarian cancer. Activation of several genes, including HER-2/neu, myc, ras, and p53 have been described in some ovarian cancers. In addition, some protooncogenes such as the epidermal growth factor receptor (erbB) and the M-CSF receptor (fms) are expressed along with the respective ligands (peptide growth factors) in some ovarian cancers. Although the studies reviewed in this paper represent a promising beginning, we remain far from a comprehensive understanding of growth regulation and transformation of human ovarian epithelium.
authors.affiliation: Department of Obstetrics and Gynecology, Duke Comprehensive Cancer Center, Durham, North Carolina.
authors.forename: A
authors.initials: A
authors.lastname: Berchuck
authors.forename: M F
authors.initials: MF
authors.lastname: Kohler
authors.forename: M P
authors.initials: MP
authors.lastname: Boente
authors.forename: G C
authors.initials: GC
authors.lastname: Rodriguez
authors.forename: R S
authors.initials: RS
authors.lastname: Whitaker
authors.forename: R C
authors.initials: RC
authors.lastname: Bast
mesh_terms: D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*; D010053:Ovary / Q000473:pathology