title: Graves' ophthalmopathy after subtotal thyroidectomy and radioiodine therapy.
abstract: Forty-five patients with Graves' ophthalmopathy were studied prospectively. Twenty-one patients (42 orbits; group 1) were treated surgically by subtotal thyroidectomy and 24 (48 orbits; group 2) received radioiodine therapy. All patients underwent tests of thyroid function, ophthalmological examination, and axial and coronal computed tomography before and 12 months after treatment. Patients in group 1 showed significant improvement in the Feldon score (P < 0.001), in proptosis as estimated by Hertel exophthalmometry (P < 0.001) and in proptosis (P < 0.001), maximum diameter of the medial rectus (P < 0.01), lateral rectus (P < 0.05), superior group (P < 0.05) and inferior rectus (P < 0.001) muscles as estimated by computed tomography. Patients in group 2 showed significant improvement only in the Feldon score (P < 0.05). The ophthalmopathy of Graves' disease improves to a greater extent after subtotal thyroidectomy than after radioiodine therapy.
authors.affiliation: Department of Surgery, University Hospital, Granada, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Fernández Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Rosell Pradas
authors.forename: O
authors.initials: O
authors.lastname: Carazo Martinez
authors.forename: E
authors.initials: E
authors.lastname: Torres Vela
authors.forename: F
authors.initials: F
authors.lastname: Escobar Jimenez
authors.forename: I
authors.initials: I
authors.lastname: Garbin Fuentes
authors.forename: R
authors.initials: R
authors.lastname: Vara Thorbeck
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006111:Graves Disease / Q000503:physiopathology / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000503:physiopathology; D011446:Prospective Studies; D013965:Thyroidectomy / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes