title: Rearrangements of c-myc and c-abl genes in tumour cells in Burkitt's lymphoma.
abstract: Rearrangements of oncogenes c-myc and c-abl were detected by non-radioactive hybridisation in a case of Burkitt's lymphoma/leukaemia. The surface phenotype of Burkitt's cells were positive for CD19, CD20, HLA-DR, CD14, CD33 and surface immunoglobulin markers. Although cytogenetic analysis was not performed, the c-myc and heavy immunoglobulin genes had the same 14.2 kilobase EcoRI molecular size fragment, suggesting a possible t(8;14) translocation which is a common marker of this malignancy. The c-abl oncogene was also rearranged in DNA digested BamHI and EcoRI. The physiopathological implications of the rearranged c-abl gene are unknown, this being the first case, as for as is known, of Burkitt's lymphoma/leukaemia with a rearranged c-abl gene.
authors.affiliation: Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Casares
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Parrado
mesh_terms: D015139:Blotting, Southern; D002051:Burkitt Lymphoma / Q000235:genetics*; D002648:Child; D015342:DNA Probes; D015321:Gene Rearrangement; D016313:Genes, abl; D016259:Genes, myc; D006801:Humans; D008297:Male
chemical_list: D015342:DNA Probes