[The cholinergic mechanisms of the excitatory effects from stimulation of the beta-adrenoreceptors in the pyloric sphincter and small intestine].
Jb been shown that beta-adrenergic stimulation by isadrine can lead to decreasing as well increasing of spre activity of the pyloric sphincter and small intestine administration of isadrine in conditions of the blockade of M- and N-cholinoreceptors suppressed the spike activity in all the portions of the intestine. The data obtained suggest that excitatory beta-adrenoreceptors are located on the cholinergic interneurons of the enteral nervous system. The suppression of the spike activity was, evidently, due to a stimulation of postsynaptic beta-adrenoreceptors.
Ovsianikov
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Aleksandrov
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AN
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D017615:Enteric Nervous System / Q000187:drug effects / Q000502:physiology; D007395:Interneurons / Q000187:drug effects / Q000502:physiology; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011708:Pylorus / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D013268:Stimulation, Chemical
D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D007545:Isoproterenol