[Chemotactic activity of serum granulocytes after aspirin in patients with aspirin-sensitive urticaria who find themselves in a state of tolerance for this drug].
The increase in neutrophil chemotactic activity (NCA) is related to degranulation of mast cells. The study included 10 patients in whom aspirin-induced urticaria was related to NCA increase. Tolerance state to ASA was achieved by administering this drug in incremental doses. In none of the examined patients after 600 mg of ASA given during induced tolerance state, the increase of NCA was observed. The authors conclude that in patients with ASA-urticaria, after ASA desensitization, mast cells degranulation does not occur.
Grzelewska-Rzymowska
I
I
Kliniki Pneumonologii i Alergologii IMW AM, Lodzi.
Szmidt
M
M
Grzegorczyk
J
J
Rozniecki
J
J
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D004342:Drug Hypersensitivity / Q000097:blood*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology
D001241:Aspirin