title: Diversity in the Chlamydia trachomatis histone homologue Hc2.
abstract: Chlamydia trachomatis elementary bodies contain two developmentally expressed histone H1 homologues. An 18-kDa histone homologue, Hc1, is conserved among C. trachomatis serovars and C. psittaci. The other histone homologue, Hc2 (encoded by hctB), varies in size between C. trachomatis serovars but is present in reduced amounts or absent from C. psittaci. The variation in Hc2 size among C. trachomatis serovars was found to be due to internal deletions from a region of the hctB gene encoding lysine- and alanine-rich pentameric repeats.
authors.affiliation: Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840.
authors.forename: T
authors.initials: T
authors.lastname: Hackstadt
authors.forename: T J
authors.initials: TJ
authors.lastname: Brickman
authors.forename: C E
authors.initials: CE
authors.lastname: Barry
authors.forename: J
authors.initials: J
authors.lastname: Sager
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D002692:Chlamydia trachomatis / Q000378:metabolism*; D002691:Chlamydophila psittaci / Q000378:metabolism; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D014644:Genetic Variation; D006657:Histones / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C082102:HctB protein, Chlamydia trachomatis; D006657:Histones