title: Efficacy and safety of repeated transcervical quinacrine pellet insertions for female sterilization.
abstract: OBJECTIVE
  To investigate the rates of tubal occlusion, pregnancy, and side effects of repeated, monthly transcervical insertions of 252 mg quinacrine as pellets.
  
  
  METHODS
  Clinical trial among 159 reproductive age women receiving two monthly transcervical insertions of 252 mg of quinacrine followed by hysterosalpingograms (HSGs) 1 month after last insertion and an additional monthly insertion among women without evidence of bilateral tubal occlusion. Contraception of women's choice provided until bilateral tubal occlusion achieved, and surgical sterilization provided for women failing to achieve bilateral tubal occlusion after third quinacrine insertion. Women were followed for at least 24 months for evidence of pregnancy or side effects.
  
  
  RESULTS
  Among the 159 women completing the protocol, 73% had evidence of bilateral tubal occlusion by HSGs after two insertions of quinacrine pellets and 94% after a third insertion. These 149 women were followed for 24 months without a pregnancy failure or serious side effect.
  
  
  CONCLUSIONS
  Transcervical applications of quinacrine as pellets have potential for safe, effective, inexpensive, and easily deliverable female sterilization.
authors.affiliation: Boulak El-Dakrour Hospital, Giza, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: el Kady
authors.forename: H S
authors.initials: HS
authors.lastname: Nagib
authors.forename: E
authors.initials: E
authors.lastname: Kessel
mesh_terms: D000328:Adult; D002584:Cervix Uteri; D004343:Drug Implants; D005186:Fallopian Tube Patency Tests; D005260:Female; D006801:Humans; D011796:Quinacrine / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D013245:Sterilization, Reproductive / Q000379:methods*; D014592:Uterine Hemorrhage / Q000139:chemically induced
chemical_list: D004343:Drug Implants; D011796:Quinacrine