(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist.
Daines
R A
RA
Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
Chambers
P A
PA
Pendrak
I
I
Jakas
D R
DR
Sarau
H M
HM
Foley
J J
JJ
Schmidt
D B
DB
Griswold
D E
DE
Martin
L D
LD
Tzimas
M N
MN
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007975:Leukotriene B4 / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D018102:Receptors, Leukotriene B4 / Q000037:antagonists & inhibitors*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D011725:Pyridines; D018102:Receptors, Leukotriene B4; C083427:(E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid; D007975:Leukotriene B4; D002118:Calcium