title: Lignocaine metabolism and liver function testing in primary graft failure following orthotopic liver transplantation.
abstract: OBJECTIVE
  To report the use of lignocaine and the measurement of its metabolite, monoethylglycinexylidide (MEGX), as a dynamic test of liver function.
  
  
  METHODS
  The conversion of lignocaine to MEGX has been used serially as a test of liver function in a liver transplant recipient for whom retransplantation was necessary because of primary non-function (PNF) of the initial graft. MEGX concentrations were markedly depressed with individual episodes of PNF, cardiac failure and rejection in this patient.
  
  
  CONCLUSIONS
  The test provided useful additional supportive information in assessment of the patient and management of intercurrent problems following liver transplantation.
authors.affiliation: Department of Clinical Pharmacology, Princess Alexandra Hospital, Woolloongabba, QLD.
authors.forename: J M
authors.initials: JM
authors.lastname: Potter
authors.forename: M
authors.initials: M
authors.lastname: Wright
authors.forename: S V
authors.initials: SV
authors.lastname: Lynch
authors.forename: R W
authors.initials: RW
authors.lastname: Strong
authors.forename: A
authors.initials: A
authors.lastname: Henderson
authors.forename: G
authors.initials: G
authors.lastname: Balderson
authors.forename: N I
authors.initials: NI
authors.lastname: Walker
authors.forename: P E
authors.initials: PE
authors.lastname: Hickman
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D008111:Liver Function Tests; D016031:Liver Transplantation; D008875:Middle Aged
chemical_list: D008012:Lidocaine; C001173:monoethylglycinexylidide