Bone induction in monkeys by bone morphogenetic protein. A trans-filter technique.
We investigated bone induction by bone morphogenetic protein in primates, comparing it with that seen in rodents. Twelve Millipore diffusion chambers containing 5 mg of semipurified bone morphogenetic protein were implanted into the dorsal muscles of 12 young, adult crab-eating monkeys (Macaca fascicularis) and were retrieved six weeks later. In six of nine unbroken chambers, new bone with haematopoietic marrow had been induced on the host-side surface of the filter. The incidence of trans-filter bone induction in the monkeys was almost equal to that observed in mice, and the new bone yield was approximately half as much as in mice. Our results show that bone morphogenetic protein can induce new bone formation in primates within six weeks, and support the hope that it will be useful as a substitute for bone graft in man.
Miyamoto
S
S
Osaka University Medical School, Japan.
Takaoka
K
K
Ono
K
K
D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D019485:Bone Morphogenetic Proteins; D015194:Diffusion Chambers, Culture; D005260:Female; D006133:Growth Substances / Q000494:pharmacology*; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011506:Proteins / Q000494:pharmacology*; D013045:Species Specificity
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins