Thioester peptide chloromethyl ketones: reagents for active site-selective labeling of serine proteinases with spectroscopic probes.
Bock
P E
PE
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
D000590:Amino Acid Chloromethyl Ketones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001665:Binding Sites; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004228:Dithionitrobenzoic Acid; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D011485:Protein Binding; D012697:Serine Endopeptidases / Q000097:blood*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds
D000590:Amino Acid Chloromethyl Ketones; D007202:Indicators and Reagents; D015842:Serine Proteinase Inhibitors; D013438:Sulfhydryl Compounds; D004228:Dithionitrobenzoic Acid; D012697:Serine Endopeptidases