Persistent hyperbilirubinemia in a healthy thoroughbred horse.
Persistent hyperbilirubinemia and icterus are described in a healthy 4-year-old Thoroughbred horse. Hyperbilirubinemia was not related to food intake and was not associated with evidence of increased hemolysis or with acquired hepatic disease. The hyperbilirubinemia was thought to be a result of inappropriate conjugation of bilirubin rather than any abnormality in bilirubin uptake or excretion. The bilirubinemia in this horse appears most similar to a human syndrome, caused by a familial deficiency of bilirubin-uridine diphosphate glucuronyl transferase.
Divers
T J
TJ
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Schappel
K A
KA
Sweeney
R W
RW
Tennant
B C
BC
D000818:Animals; D003414:Crigler-Najjar Syndrome / Q000662:veterinary; D006734:Horse Diseases / Q000175:diagnosis*; D006736:Horses; D006932:Hyperbilirubinemia / Q000175:diagnosis / Q000662:veterinary*; D007565:Jaundice / Q000175:diagnosis / Q000662:veterinary; D008297:Male