Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging.
A new cationic complex, [99mTc(tetrofosmin)2O2]+, where tetrofosmin is the ether functionalized diphosphine ligand 1,2-bis[bis(2-ethoxyethyl)phosphino]ethane, has been synthesized and evaluated for potential use in myocardial perfusion imaging. The structure of the complex has been determined by x-ray crystallography of the 99Tc analog. In comparison with previously reported 99mTc complexes of alkyl-phosphines, the tetrofosmin species shows substantially increased clearance from nontarget tissue, especially blood and liver. A freeze-dried kit formulation has been developed. The kit provides a product of high radiochemical purity up to 8 hr after reconstitution at room temperature.
Kelly
J D
JD
Pharmaceuticals Research and Development, Amersham International plc, Buckinghamshire, United Kingdom.
Forster
A M
AM
Higley
B
B
Archer
C M
CM
Booker
F S
FS
Canning
L R
LR
Chiu
K W
KW
Edwards
B
B
Gill
H K
HK
McPartlin
M
M
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000000981:diagnostic imaging*; D008297:Male; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000633:toxicity; D015609:Organotechnetium Compounds / Q000737:chemistry* / Q000633:toxicity; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D013552:Swine; D013556:Swine, Miniature; D014018:Tissue Distribution
D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin