title: Gamma probe assisted ex vivo detection of small lymph node metastases following the administration of indium-111-labeled monoclonal antibodies to colorectal cancers.
abstract: This study evaluated the ability of ex vivo gamma-probe scanning to detect lymph node metastases in resected surgical specimens from primary colorectal carcinoma patients undergoing external scintigraphy following intravenous administration of 4.1-5.3 mCi of 111In-labeled anti CEA monoclonal antibodies. The ex vivo probe counting technique led to a twofold to fourfold increase in the number of detectable lymph nodes with the majority measuring 2-5 mm in diameter. Results indicate a potentially useful role for ex vivo probe counting in detection and mapping small (2-5 mm) lymph nodes metastases.
authors.affiliation: Department of Nuclear Medicine, State University of New York at Buffalo 14214.
authors.forename: H
authors.initials: H
authors.lastname: Abdel Nabi
authors.forename: R J
authors.initials: RJ
authors.lastname: Doerr
authors.forename: D
authors.initials: D
authors.lastname: Balu
authors.forename: L
authors.initials: L
authors.lastname: Rogan
authors.forename: E L
authors.initials: EL
authors.lastname: Farrell
authors.forename: N H
authors.initials: NH
authors.lastname: Evans
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D015902:Gamma Cameras; D006801:Humans; D066298:In Vitro Techniques; D007205:Indium Radioisotopes; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008722:Methods; D008875:Middle Aged; D011446:Prospective Studies; D016719:Radioimmunodetection
chemical_list: D007205:Indium Radioisotopes