Effect of triglycyl-lysine-vasopressin on skin blood flow and blood loss during wound excision in patients with burns.
Excisional therapy often results in large-volume blood loss. Triglycyl-lysine-vasopressin selectively decreases dermal blood flow and therefore was tested for efficacy in limiting intraoperative blood loss in a series of patients undergoing excisional therapy. Ten patients with symmetric injuries were treated with intravenous triglycyl-lysine-vasopressin after excision of half of their burn wound. Blood loss, which was quantified by weighing sponges used to absorb shed blood, was significantly decreased after treatment. Triglycyl-lysine-vasopressin treatment was safe and effective and should be considered in cases when large-volume blood loss is expected.
Garner
W L
WL
Department of Surgery, University of Michigan School of Medicine, Ann Arbor.
Thomson
P D
PD
Moore
N P
NP
Rodriguez
J L
JL
Smith
D J
DJ
D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002056:Burns / Q000601:surgery*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D011292:Premedication; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D000077585:Terlipressin
D008236:Lypressin; D000077585:Terlipressin