Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2.
The cellular transcription factor SP1 binds to critical regulatory elements in a variety of cellular and viral promoters. The gene encoding the approximately 100-kDa SP1 protein contains zinc finger DNA-binding domains and glutamine-activation domains. Since SP1 is involved in the regulation of a variety of cellular genes, we wished to determine its chromosomal localization. Southern blot analysis of genomic DNA from a panel of mouse x human somatic cell hybrids indicated that SP1 was localized to chromosome 12. In situ hybridization allowed the localization of the gene encoding SP1 to human chromosome 12q12-->q13.2, with 12q13.1 being the most probable location.
Gaynor
R B
RB
Department of Medicine and Microbiology, University of Texas Southwestern Medical School, Dallas 75235-8594.
Shieh
B H
BH
Klisak
I
I
Sparkes
R S
RS
Lusis
A J
AJ
D000818:Animals; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D016329:Sp1 Transcription Factor / Q000235:genetics*
D016329:Sp1 Transcription Factor