Effects of prior cocaine exposure on subsequent neuronal responsiveness.
In vivo electrophysiological experiments were conducted to examine the responses of single, spontaneously-active neostriatal neurons to repeated cocaine exposure. The second of two administrations in a 30 min interval, attenuated the magnitude and duration of cocaine-induced depression in discharge rate, and enhanced the same variables for cocaine-evoked excitation. These findings indicate that the responsiveness of striatal neurons to cocaine may vary predictably as a function of previous exposure.
Nantwi
K D
KD
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201.
Schoener
E P
EP
D017109:Akathisia, Drug-Induced; D000818:Animals; D003042:Cocaine / Q000633:toxicity*; D003342:Corpus Striatum / Q000187:drug effects; D003863:Depression / Q000139:chemically induced; D004594:Electrophysiology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003042:Cocaine