Expression of cellular oncogenes in human gastric carcinoma: c-myc, c-erb B2, and c-Ha-ras.
Expression of oncogenes in gastric cancer tissue was evaluated with immunohistochemical staining methods using monoclonal antibodies to products of the oncogenes. Rates of expression in gastric cancer tissue were 50% for c-myc, 72% for c-erb B2, and 56% for c-Ha-ras oncogenes. Expression of these oncogenes in gastric cancer was not correlated with the histologic differentiation. The c-Ha-ras oncogene was positive in 19 of 26 cases with lymph node and/or distant metastasis: the positive rate was significantly higher than in cases without metastasis. Results suggest that c-Ha-ras oncogene is related to the prognosis of gastric cancer. The rate of expression of c-myc and c-Ha-ras oncogenes in gastric cancer tissues was higher in the DNA aneuploid group than in the DNA diploid group. Expression of c-myc and c-Ha-ras oncogenes correlated with other prognostic factors such as DNA ploidy pattern and metastasis. These oncogenes can be used to evaluate prognosis of gastric cancer patients.
Kim
Y J
YJ
Department of Surgery, Chonnam University Medical School, Kwangju, Korea.
Ghu
H D
HD
Kim
D Y
DY
Kim
H J
HJ
Kim
S K
SK
Park
C S
CS
D004273:DNA, Neoplasm / Q000235:genetics; D015870:Gene Expression; D016259:Genes, myc / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D011003:Ploidies; D011519:Proto-Oncogenes / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm