title: Treatment and follow-up strategies in hereditary nonpolyposis colorectal carcinoma.
abstract: The treatment and follow-up strategies of patients with hereditary nonpolyposis colorectal carcinoma (HNPCC) were analyzed in 22 Finnish HNPCC families in systematic follow-up between 1983 and 1990. During the seven-year study period metachronous colorectal neoplasia was diagnosed in 41 percent (15/37) of the patients treated by segmental colonic resection and in 24 percent (4/17) of those treated by subtotal colectomy. Extracolonic carcinoma was diagnosed in 12 (30 percent) of the 40 patients during the long-term follow-up. The most common extracolonic malignancy was biliopancreatic carcinoma which accounted for all five cancer-related deaths in the whole series during the study period. It was concluded that subtotal colectomy is superior to hemicolectomy or segmental resection in HNPCC patients with colorectal carcinoma. A regular annual endoscopic follow-up of the residual rectum is still necessary, and surveillance for extracolonic cancers must be considered.
authors.affiliation: Department of Surgery, Jyväskylä Central Hospital, Finland.
authors.forename: J P
authors.initials: JP
authors.lastname: Mecklin
authors.forename: H
authors.initials: H
authors.lastname: Järvinen
mesh_terms: D000328:Adult; D000368:Aged; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged