[Study of cytopathogenic effect of epidemic hemorrhagic fever virus on normal human bone marrow cells].
The cytopathogenic effect of epidemic hemorrhagic fever virus (EHFV) on cultured human bone marrow cells (HBC) was studied. Specific viral antigen in HBC was detected at various times after EHFV infection with trypan-blue stain and electron microscopy. It was shown that the infection rate of HBC was over 80% at 3 weeks after infection. The death rate of HBC in the infection group was significantly higher than that in the control group on 1-4 weeks after infection. Injury of cell membrane organs after infection with EHFV were significantly earlier and more severe as it was shown by electron microscopy. It was demonstrated that EHFV could cause cytopathogenic effect on cells of nomal human bone marrow.
Luo
D D
DD
Department of Infectious Diseases, Union Hospital, Tongji Medical University.
Zeng
L L
LL
Guo
J S
JS
D000956:Antigens, Viral / Q000032:analysis; D001853:Bone Marrow / Q000382:microbiology* / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D006476:Orthohantavirus / Q000472:pathogenicity*; D006801:Humans; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D014343:Trypan Blue
D000956:Antigens, Viral; D014343:Trypan Blue