A clinico-pathological study of adult histiocytosis X involving the brain.
Adult histiocytosis X involving the CNS caused progressive spastic paraparesis. The diagnosis was made by immunoreactive anti-S100 protein antibody staining and from the presence of Birbeck granules in biopsy specimens of skin lesions. Neuropathological examination showed massive proliferation and infiltration of S-100 containing histiocyte-like cells and reactive astrocytes throughout the CNS.
Hasegawa
K
K
Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
Mitomi
T
T
Kowa
H
H
Motoori
T
T
Yagisita
S
S
D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000209:etiology; D010243:Paralysis / Q000209:etiology; D012867:Skin / Q000473:pathology