title: Sub ablation effects of the KTP laser on wound healing.
abstract: The KTP laser (wavelength 532 nm) was used in a sub ablative format to determine the effect of low energy density irradiation on the normal healing by primary intention of scalpel skin incisions in rats. Two longitudinal lased strips were created by a 1 cm diameter defocused beam on the shaved, cleaned dorsal epidermis of 32 Sprague-Dawley rates; one strip was produced with a 2.0 W beam (54 J, or 18 J/cm2 total dose), and the other with a 3.5 W beam (94.5 J or 31.5 J/cm2, total dose). Scalpel incisions were made longitudinally within the irradiated zones, using contra lateral scalpel incisions on unirradiated skin as controls. Tensiometric analysis of wound strength was performed at 3, 7, 14, and 23 days following surgery. The data from fresh tissue tensiometry indicate that KTP laser irradiation of skin incisions results in a lower tensile strength for the wound at 7 and 14 days. The decrease in tensile strength is proportional to the total energy density of the exposure. At day 3 and 23, the tensile strength of the wound was independent of the sub ablative laser exposure. The results are in general agreement with studies of the healing process of laser incisions and may help us to understand the details of the healing process from laser incisions.
authors.affiliation: Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: M D
authors.initials: MD
authors.lastname: Kyzer
authors.forename: A S
authors.initials: AS
authors.lastname: Aly
authors.forename: J M
authors.initials: JM
authors.lastname: Davidson
authors.forename: L
authors.initials: L
authors.lastname: Reinisch
authors.forename: R H
authors.initials: RH
authors.lastname: Ossoff
mesh_terms: D000818:Animals; D002056:Burns / Q000209:etiology; D006358:Hot Temperature / Q000009:adverse effects; D053685:Laser Therapy / Q000009:adverse effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000503:physiopathology / Q000528:radiation effects*; D013718:Tensile Strength; D014945:Wound Healing / Q000528:radiation effects*