Effects of caffeine and PD 116,600 on the differential-reinforcement-of-low rate 72-S (DRL 72-S) schedule of reinforcement.
Caffeine and PD 116,600 were found to decrease the reinforcement rate and increase the response rate in rats performing under a differential-reinforcement-of-low rate 72-s (DRL 72-s) schedule of reinforcement. In contrast, antidepressant drugs previously have been found to increase the reinforcement and decrease the response rate. Caffeine has been found to test similar to antidepressant drugs on at least one other behavioral screen, but caffeine does not possess clinical antidepressant properties. These results provide further support for the DRL 72-s schedule as a behavioral screen for antidepressant drugs.
Marek
G J
GJ
University of Chicago, Department of Pharmacological and Physiological Sciences, IL 60637.
Heffner
T G
TG
Richards
J B
JB
Shaughnessy
R A
RA
Li
A A
AA
Seiden
L S
LS
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology
D000928:Antidepressive Agents; C053907:8-cyclopentyl-1,3-dimethylxanthine; D002110:Caffeine; D013806:Theophylline