title: Prevalence survey of precancerous lesions of the oesophagus in a high-risk population for oesophageal cancer in France.
abstract: The prevalence of precancerous lesions of the oesophagus and their association with alcohol drinking, tobacco smoking and some dietary factors were examined in an endoscopic survey carried out in Lower Normandy, France, a high-risk area for oesophageal cancer. The study included 134 male volunteers of 35-64 years of age. In 124 of the volunteers oesophageal biopsies were evaluable. At histology, the prevalence of chronic oesophagitis, epithelial atrophy and dysplasia was 63%, 1.6% and 4.8%, respectively. The prevalence of these precancerous lesions was significantly associated with cigarette smoking and frequent consumption of butter.
authors.affiliation: Centre Régional François Baclesse, Caen, France.
authors.forename: J H
authors.initials: JH
authors.lastname: Jacob
authors.forename: A
authors.initials: A
authors.lastname: Riviere
authors.forename: A M
authors.initials: AM
authors.lastname: Mandard
authors.forename: N
authors.initials: N
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Crespi
authors.forename: Y
authors.initials: Y
authors.lastname: Etienne
authors.forename: X
authors.initials: X
authors.lastname: Castellsagué
authors.forename: J
authors.initials: J
authors.lastname: Marnay
authors.forename: G
authors.initials: G
authors.lastname: Lebigot
authors.forename: S L
authors.initials: SL
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D004941:Esophagitis / Q000453:epidemiology*; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology; D005247:Feeding Behavior; D005602:France / Q000453:epidemiology; D006801:Humans; D007971:Leukoplakia / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking