title: Unusual form of endobronchial Aspergillosis in a patient with cystic fibrosis.
abstract: The isolation of Aspergillus fumigatus from airway secretions from patients with cystic fibrosis (CF) is common and usually denotes asymptomatic colonization or allergic broncho-pulmonary aspergillosis (ABPA). A 12-year-old boy with CF acutely developed moderately severe symptoms of unremitting cough, fever, dyspnea, weight loss, and cyanosis. Chest radiographs demonstrated widespread unilateral infiltrates and volume loss. By bronchoscopy tenacious mucous plugs were seen occluding the left lower lobe bronchus. Cultures from sputum and sequential bronchoalveolar lavage grew Aspergillus fumigatus, but other significant criteria for diagnosing ABPA were lacking. No improvement was seen with a 3 week course of systemic corticosteroid and antibiotic therapy. Treatment with amphotericin B and short-term mechanical ventilation resulted in rapid resolution of all symptoms. This form of endobronchial aspergillosis has not been described previously.
authors.affiliation: Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198-5190.
authors.forename: P H
authors.initials: PH
authors.lastname: Sammut
authors.forename: S T
authors.initials: ST
authors.lastname: Howard
authors.forename: J
authors.initials: J
authors.lastname: Linder
authors.forename: J L
authors.initials: JL
authors.lastname: Colombo
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001999:Bronchoscopy; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D006801:Humans; D008297:Male; D012121:Respiration, Artificial
chemical_list: D000666:Amphotericin B