Dietary electrolytes and urinary natriuretic factors.
We examined the relationship between the excretion of electrolytes (sodium, potassium and calcium), dopamine and digoxin-like immunoreactive substance in 41 young healthy female subjects (age 18-23 years) in order to study the interaction of electrolyte intake on dopamine and digoxin-like immunoreactive substance--factors which have been postulated to have a pathogenic role in hypertension. Sodium excretion was significantly correlated with dopamine excretion (r = 0.545, P < 0.0005) and digoxin-like immunoreactive substance (r = 0.359, P < 0.02). There was also a significant correlation between calcium and digoxin-like immunoreactive substance (r = 0.345, P < 0.03). Stepwise multiple regression analysis further confirmed that sodium is the only contributor to dopamine excretion and calcium is the only contributor to digoxin-like immunoreactive substance (r2 = 0.114). We conclude that in young healthy subjects dopamine excretion is determined partly by sodium intake and that the excretion of digoxin-like immunoreactive substance is independent of sodium intake.
Ho
C S
CS
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
Ho
S C
SC
Swaminathan
R
R
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000652:urine*; D002298:Cardenolides; D004077:Digoxin; D004298:Dopamine / Q000652:urine*; D004573:Electrolytes / Q000008:administration & dosage* / Q000652:urine; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000652:urine; D012016:Reference Values; D012503:Saponins
D001798:Blood Proteins; D002298:Cardenolides; D004573:Electrolytes; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D004298:Dopamine