title: Vitiligo, rheumatoid arthritis and pernicious anemia.
abstract: A patient with a 46-year history of vitiligo who also presented rheumatoid arthritis and pernicious anemia is described. Meticulous physical examination excluded further systemic or cutaneous involvement. The immunological workup revealed a low CD4 cell percentage with T cells mostly composed of CD8 cells, a discrepancy between the high percentage of cumulative CD4 + CD8 cells and the measured CD3 proportions, very low NK cytotoxicity toward K562 cells, and almost negligible responses to PHA, Con A and PWM mitogens. The results point to severe T and NK cell functional defects. The pathogenetic significance of these data is discussed.
authors.affiliation: Department of Dermatology, Reish Policlinic, Haifa, Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Abraham
authors.forename: M
authors.initials: M
authors.lastname: Rozenbaum
authors.forename: Z
authors.initials: Z
authors.lastname: Glück
authors.forename: E J
authors.initials: EJ
authors.lastname: Feuerman
authors.forename: N
authors.initials: N
authors.lastname: Lahat
authors.forename: A
authors.initials: A
authors.lastname: Kinarty
mesh_terms: D000368:Aged; D000752:Anemia, Pernicious / Q000150:complications* / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D014820:Vitiligo / Q000150:complications* / Q000276:immunology*