title: Chronic bullous disease of childhood and ulcerative colitis.
abstract: A 12-year-old girl with ulcerative colitis (UC) treated by colectomy with rectal stump preservation, salazopyrin, and systemic steroids developed persistent mouth ulcers, cutaneous targetlike lesions, papulopustules, and bullae. The clinical, histologic, and immunopathologic features were typical of chronic bullous disease of childhood (CBDC). Although resistant to combined immunosuppressive therapy with low-dose prednisolone, cyclosporin, and thalidomide, striking remission of the mucocutaneous symptoms resulted with surgical resection of the diseased rectal stump. An etiologic association between CBDC and UC is postulated.
authors.affiliation: Department of Dermatology, Royal Victoria Hospital, Belfast, North Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Handley
authors.forename: M
authors.initials: M
authors.lastname: Shields
authors.forename: J
authors.initials: J
authors.lastname: Dodge
authors.forename: M
authors.initials: M
authors.lastname: Walsh
authors.forename: A
authors.initials: A
authors.lastname: Bingham
mesh_terms: D002648:Child; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D012872:Skin Diseases, Vesiculobullous / Q000209:etiology* / Q000473:pathology / Q000628:therapy