Conformation of tropolone ring in antileukemic tropoloisoquinoline alkaloids.
Conformational analysis of antileukemic tropoloisoquinoline alkaloids isolated from Cissampelos pareira was conducted by thermodynamic proton nuclear magnetic resonance (1H NMR) studies. The line-broadening of one of methoxy methyl signals can be explained by the tropolone ring-puckering process. Analysis by dynamical simulated annealing and modified neglect of differential overlap (MNDO) calculations also supported puckering of tropolone ring system.
Morita
H
H
Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
Matsumoto
K
K
Takeya
K
K
Itokawa
H
H
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology; D007938:Leukemia / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D014334:Tropolone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D007546:Isoquinolines; D014334:Tropolone