[Necrotizing myopathy with antilipemic agents. Case report and review of the literature].
A 73 year old male who had been prescribed fenofibrate for years developed a slightly asymmetric paraparesis of both lower extremities. CPK values rose to 9800 U/l, EMG of the quadriceps femoris muscle was myopathic. Muscle biopsy revealed a necrotic myopathy. Discontinuation of fenofibrate induced a rapid decline of CPK values, followed by a slower remission of muscular symptoms and persisting pseudo-myotonic discharges in EMG. The spectrum of neuromuscular side effects of cholesterol lowering agents, consisting of myalgia, cramps and reversible CPK elevation, is discussed. Only rarely necrotic myopathies have been described.
Berger
O
O
Neurologische Abteilung, Kaiser Franz Josef Spital, Wien.
Zifko
U
U
Jellinger
K
K
Machacek
E
E
Grisold
W
W
D000368:Aged; D001706:Biopsy; D003402:Creatine Kinase / Q000097:blood; D004576:Electromyography / Q000187:drug effects; D011345:Fenofibrate / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000473:pathology; D008134:Long-Term Care; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000187:drug effects* / Q000294:innervation / Q000473:pathology; D009336:Necrosis; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology; D009435:Synaptic Transmission / Q000187:drug effects
D003402:Creatine Kinase; D011345:Fenofibrate