title: Histamine metabolism in nasal polyps.
abstract: We attempted to determine the relationship of nasal polyps to histamine (HA) metabolism. Compared to that in allergy-related nasal polyps and infection-related nasal polyps, the level of HA in aspirin-induced asthma-related polyps was significantly lower. Large differences between the groups were not observed in HA-synthesizing enzyme activity, but degradative enzyme activity was much higher in aspirin-induced asthma-related polyps than in other types  of nasal polyps tested. These findings suggest the possibility that the amount of HA in polyps associated with aspirin-induced asthma was less because of greatly enhanced degradation. We found, in addition, that in nasal tissues such as polyps, histamine-N-methyl transferase, rather than histaminase, was the principal degradative enzyme.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Osaka University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ogino
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Irifune
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: I
authors.initials: I
authors.lastname: Imamura
authors.forename: H
authors.initials: H
authors.lastname: Fukui
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D001241:Aspirin; D001249:Asthma / Q000139:chemically induced / Q000150:complications; D001985:Bronchial Provocation Tests; D006632:Histamine / Q000378:metabolism*; D006637:Histamine N-Methyltransferase / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000378:metabolism; D006801:Humans; D009298:Nasal Polyps / Q000150:complications / Q000378:metabolism*; D012852:Sinusitis / Q000150:complications
chemical_list: D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D006637:Histamine N-Methyltransferase; D006640:Histidine Decarboxylase; D001241:Aspirin