Analysis of the risk factors with regard to the occurrence of ectopic pregnancy after medically assisted procreation.
In a retrospective study (1985-1989) based on data from the Centre for Reproductive Medicine in Brussels, a total of 23 ectopic pregnancies (2.24%) occurred after 3800 embryo, zygote or gamete transfers. This number was low compared with the data published elsewhere. Tubal damage was a major risk factor towards developing an ectopic pregnancy after in-vitro fertilization and embryo transfer. The number of ectopic pregnancies after the association of clomiphene citrate and human menopausal gonadotrophin (HMG) was significantly higher in patients with tubal (7.8%) and non-tubal indications (2.1%) compared with those stimulated with gonadotrophin-releasing hormone (GnRH) and HMG (2.18% and 0.84%, respectively). The number of replaced embryos was not associated with the rate of ectopic pregnancy and neither did transfer technique (intra-uterine or intra-Fallopian transfer) influence the ectopic pregnancy rate.
Verhulst
G
G
Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Belgium.
Camus
M
M
Bollen
N
N
Van Steirteghem
A
A
Devroey
P
P
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D004624:Embryo Transfer; D005184:Fallopian Tube Diseases / Q000150:complications; D005260:Female; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D008596:Menotropins / Q000627:therapeutic use; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis / Q000209:etiology*; D012099:Reproductive Techniques / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D017388:Zygote Intrafallopian Transfer
D002996:Clomiphene; D008596:Menotropins