title: Effect of triglycyl-lysine-vasopressin on skin blood flow and blood loss during wound excision in patients with burns.
abstract: Excisional therapy often results in large-volume blood loss. Triglycyl-lysine-vasopressin selectively decreases dermal blood flow and therefore was tested for efficacy in limiting intraoperative blood loss in a series of patients undergoing excisional therapy. Ten patients with symmetric injuries were treated with intravenous triglycyl-lysine-vasopressin after excision of half of their burn wound. Blood loss, which was quantified by weighing sponges used to absorb shed blood, was significantly decreased after treatment. Triglycyl-lysine-vasopressin treatment was safe and effective and should be considered in cases when large-volume blood loss is expected.
authors.affiliation: Department of Surgery, University of Michigan School of Medicine, Ann Arbor.
authors.forename: W L
authors.initials: WL
authors.lastname: Garner
authors.forename: P D
authors.initials: PD
authors.lastname: Thomson
authors.forename: N P
authors.initials: NP
authors.lastname: Moore
authors.forename: J L
authors.initials: JL
authors.lastname: Rodriguez
authors.forename: D J
authors.initials: DJ
authors.lastname: Smith
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002056:Burns / Q000601:surgery*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D011292:Premedication; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D000077585:Terlipressin
chemical_list: D008236:Lypressin; D000077585:Terlipressin