False-negative cerebrospinal fluid cryptococcal latex agglutination tests for patients with culture-positive cryptococcal meningitis.
Three cases of false-negative cerebrospinal fluid latex agglutination test results for patients with culture-positive cryptococcal meningitis are reported. False-negative results occurred in settings of low cryptococcal antigen concentrations in cerebrospinal fluid and were dependent on the latex agglutination test kit used. Investigation of each case revealed that prozone phenomena or interference from bound antibody or protein could not account for the false-negative results.
Currie
B P
BP
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
Freundlich
L F
LF
Soto
M A
MA
Casadevall
A
A
D000328:Adult; D000946:Antigens, Fungal / Q000134:cerebrospinal fluid*; D003455:Cryptococcus neoformans / Q000276:immunology* / Q000302:isolation & purification; D005188:False Negative Reactions; D006801:Humans; D007841:Latex Fixation Tests; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis*; D008875:Middle Aged
D000946:Antigens, Fungal