title: Synthesis and biological activity of 3-(N-substituted pyridinium-4-thiomethyl)-7 alpha-formamido cephalosporins.
abstract: The synthesis and antibacterial activity of a series of 3-(1-substituted pyridinium-4-thiomethyl)-7 alpha-formamido cephalosporins is described. All the derivatives showed good potency and stability to bacterial beta-lactamases. The antibacterial efficacy seen with the N-alkyl pyridinium substituents was enhanced by the introduction of a catecholic side chain at C-7 and by preparation of N-(substituted amino)pyridinium derivatives.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, U.K.
authors.forename: A W
authors.initials: AW
authors.lastname: Guest
authors.forename: R G
authors.initials: RG
authors.lastname: Adams
authors.forename: M J
authors.initials: MJ
authors.lastname: Basker
authors.forename: E G
authors.initials: EG
authors.lastname: Brain
authors.forename: C L
authors.initials: CL
authors.lastname: Branch
authors.forename: F P
authors.initials: FP
authors.lastname: Harrington
authors.forename: J E
authors.initials: JE
authors.lastname: Neale
authors.forename: M J
authors.initials: MJ
authors.lastname: Pearson
authors.forename: I I
authors.initials: II
authors.lastname: Zomaya
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins