title: Wegener's granulomatosis with peripheral eosinophilia. Atypical variant of a classic disease.
abstract: A patient with Wegener's granulomatosis (WG) diagnosed by ultrasound-guided transthoracic biopsy of a pulmonary nodule is reported. The case is atypical because of marked eosinophilia in the peripheral blood and the pleural effusion. The granulomatous infiltrate of the lung showed the classic picture of WG without eosinophils. The patient responded dramatically to treatment with steroids and cyclophosphamide. This variant form of WG poses problems in its distinction from Churg-Strauss syndrome, and the differential diagnosis between these two entities is discussed.
authors.affiliation: Department of Internal Medicine, Kaplan Hospital, Rehovot, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Krupsky
authors.forename: Z
authors.initials: Z
authors.lastname: Landau
authors.forename: B
authors.initials: B
authors.lastname: Lifschitz-Mercer
authors.forename: P
authors.initials: P
authors.lastname: Resnitzky
mesh_terms: D000328:Adult; D001706:Biopsy; D015267:Churg-Strauss Syndrome / Q000175:diagnosis; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications*; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D010996:Pleural Effusion / Q000150:complications