Human glutathione S-transferase mu (GST mu) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers.
The isoenzyme mu of glutathione S-transferase (GST mu) is dominantly inherited and the prevalence of this isoenzyme in the population is about 60%. An increased risk of lung cancer has been previously shown among smokers lacking GST mu in (Seidegard J., Pero R.W., Miller D.G., Beattie E.J. (1986) Carcinogenesis, 7, 751-753). The frequency of the phenotypes of this isoenzyme in bladder cancer patients (n = 75), in larynx cancer patients (n = 78) and healthy controls matched for age and smoking history is reported here. A significantly higher proportion of smokers in the control group had measurable GST mu compared with bladder cancer patients (54.6% vs. 33.3%, P < 0.01) and also compared to larynx cancer patients (55.1% vs. 33.3%, P < 0.01). Odds ratio analysis indicates that smokers with this polymorphic variant have an approximately 2-fold greater risk of developing these cancers.
Lafuente
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Institut de Salut Pública, Universitat de Barcelona, Spain.
Pujol
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Carretero
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Villa
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JP
Cuchi
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000097:blood / Q000172:deficiency*; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000172:deficiency; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000209:etiology; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000209:etiology
D005819:Genetic Markers; D007527:Isoenzymes; D005982:Glutathione Transferase