title: Limb salvage and wound coverage in patients with large ischemic ulcers: a multidisciplinary approach with revascularization and free tissue transfer.
abstract: OBJECTIVE
  Large ischemic wounds, particularly with exposed bone or tendons, may not heal even after successful revascularization. We have taken an aggressive approach for limb salvage that uses autogenous vein grafting and simultaneous microvascular free tissue transfer.
  
  
  METHODS
  In the past year, seven patients (average age 67 years; range 56 to 79) with ischemic disease and distal ulceration underwent revascularization for limb salvage and free tissue transfer. Each had a nonhealing wound (average size 80 cm2), present for 8.6 months (range 2 to 24 months). Simultaneous vein bypass and free tissue transfer was performed in four (57%) of the seven patients.
  
  
  RESULTS
  All flaps were initially viable; however, one was lost on day 4 because of hypotension and congestive heart failure. One patient with a successful flap died at 1 month of pneumonia. Minor wound complications were seen in four (57%) of seven patients. Five of the seven patients had the wounds heal completely and are ambulatory at an average follow up of 10 months.
  
  
  CONCLUSIONS
  Our aggressive approach was successful in preserving limb length and function in 71% of our patients. We perform simultaneous procedures whenever possible to minimize operative and hospitalization times. We believe that this combined approach optimizes the treatment of ischemic limbs with large ulcers.
authors.affiliation: Division of Plastic and Reconstructive Surgery, University of California San Francisco 94143-0932.
authors.forename: K F
authors.initials: KF
authors.lastname: Ciresi
authors.forename: J P
authors.initials: JP
authors.lastname: Anthony
authors.forename: W Y
authors.initials: WY
authors.lastname: Hoffman
authors.forename: J C
authors.initials: JC
authors.lastname: Bowersox
authors.forename: L M
authors.initials: LM
authors.lastname: Reilly
authors.forename: J H
authors.initials: JH
authors.lastname: Rapp
mesh_terms: D000368:Aged; D001158:Arteries / Q000601:surgery; D003646:Debridement; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007511:Ischemia / Q000601:surgery*; D007866:Leg / Q000098:blood supply* / Q000601:surgery*; D007871:Leg Ulcer / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000637:transplantation; D011183:Postoperative Complications; D013524:Surgical Flaps / Q000379:methods*; D013997:Time Factors