A familial syndrome with cutaneous malignant melanoma and cerebral astrocytoma.
We describe a family in which cutaneous malignant melanoma or cerebral astrocytoma, or both, developed in eight members over three generations. Other malignancies also occurred with a lesser frequency. In two patients with both malignant melanoma and astrocytoma, the brain tumor followed the diagnosis of melanoma by a period of 2 and 10 years and was the primary cause of morbidity and mortality. The findings in this family may represent a newly described genetic disorder.
Kaufman
D K
DK
Department of Neurology, Mayo Clinic, Rochester, MN 55905.
Kimmel
D W
DW
Parisi
J E
JE
Michels
V V
VV
D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008545:Melanoma / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D012878:Skin Neoplasms / Q000150:complications / Q000235:genetics*; D013577:Syndrome