title: A protein required for secretion of cholera toxin through the outer membrane of Vibrio cholerae.
abstract: A gene essential for the secretion of cholera toxin from the periplasm of Vibrio cholerae into the extracellular medium has been isolated and its nucleotide sequence determined. It encodes a cytoplasmic protein of 56 kDa that exhibits a high degree of similarity to gene products required for extracellular protein secretion in several other Gram- organisms. Sequence similarities in its potential ATP-binding site suggest that the protein may act as an energy provider or signal transducer in the process of extracellular secretion.
authors.affiliation: Department of Microbiology, Michigan State University, East Lansing 48824.
authors.forename: M
authors.initials: M
authors.lastname: Sandkvist
authors.forename: V
authors.initials: V
authors.lastname: Morales
authors.forename: M
authors.initials: M
authors.lastname: Bagdasarian
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002462:Cell Membrane / Q000378:metabolism*; D002772:Cholera Toxin / Q000235:genetics* / Q000378:metabolism; D004269:DNA, Bacterial; D015723:Gene Library; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D014734:Vibrio cholerae / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C079398:EpsE protein, Vibrio cholerae; D008565:Membrane Proteins; D002772:Cholera Toxin