Trisomy 4 may occur in a broad range of hematologic malignancies.
Trisomy 4 is an uncommon numerical chromosomal aberration in acute leukemia. We describe three cases of trisomy 4, occurring in two patients with acute myeloid leukemia (M1 and M5a) and in one patient with T-cell acute lymphoblastic leukemia. Our results suggest that trisomy 4 may occur in a broader range of hematologic and malignancies than previously described.
Kwong
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YL
Haematology Section, University Department of Pathology, Queen Mary Hospital, Hong Kong.
Ha
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Liu
H W
HW
Chan
L C
LC
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014314:Trisomy