Interleukin-2 receptor alpha chain on acute myelocytic leukemia cells is involved in cell-to-cell interactions.
Leukemic cells from 21 to 197 adult patients with de novo acute myelocytic leukemia (AML) were positive for IL-2R alpha chain (IL-2R alpha), whereas IL-2R beta chain (IL-2R beta), which is responsible for IL-2 signal transduction, was not found on leukemic cells from any of these cases tested. The expression of IL-2R alpha was closely associated with that of adhesion molecules CD4, CD11b and CD22, and endopeptidase CD10. None of the IL-2R alpha (+) AML cells responded to recombinant human IL-2. These data suggest that IL-2R alpha on AML cells may not be involved in cellular proliferation as one of growth factor receptors but may have a role in the control of cell-to-cell interactions.
Nakase
K
K
Department of Internal Medicine, Yamada Red Cross Hospital, Misono, Japan.
Kita
K
K
Otsuji
A
A
Anazawa
H
H
Shirakawa
S
S
Nasu
K
K
Dohy
H
H
Tsutani
H
H
Tanaka
I
I
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002450:Cell Communication; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology
D015703:Antigens, CD; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins