title: Preliminary findings on the variation of serum apolipoprotein levels in neural degenerative disorders.
abstract: We measured six apolipoproteins (AI, AII, B, CII, CIII, and E) in the serum of patients with several kinds of neural diseases [diabetic neuropathy and neural degenerative disorders (motor neuron degenerative disorders, spinocerebellar degeneration, Parkinson's disease)], comparing them to the age-matched healthy controls using the immunoturbidimetric method. Statistically significant decreases of serum apo-AI, apo-A-II and increases of apo-CIII, apo-E were observed in neural degenerative diseases; and, particularly, higher apo-B and apo-CII concentrations were observed in diabetic neuropathy. Most neural degenerative disease showed lower apo-AII. However, in motor neuron degenerative disorders, higher apo C-II and apo-E were seen. Lower apo-AI was seen in spinocerebellar degeneration, and lower apo-AII was seen in Parkinson's disease. Higher apo-B, CII, and E levels were observed in females with spinocerebellar degeneration and Parkinson's disease, and lower apo-AII was seen in males with spinocerebellar disease.
authors.affiliation: Department of Central Laboratory, Kumamoto University Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Sugiuchi
authors.forename: U
authors.initials: U
authors.lastname: Senba
authors.forename: Y
authors.initials: Y
authors.lastname: Shibuya
authors.forename: Y
authors.initials: Y
authors.lastname: Uji
authors.forename: H
authors.initials: H
authors.lastname: Okabe
authors.forename: S
authors.initials: S
authors.lastname: Araki
mesh_terms: D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D003929:Diabetic Neuropathies / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000097:blood; D009410:Nerve Degeneration / Q000502:physiology; D009422:Nervous System Diseases / Q000097:blood* / Q000175:diagnosis; D010300:Parkinson Disease / Q000097:blood; D013132:Spinocerebellar Degenerations / Q000097:blood
chemical_list: D001053:Apolipoproteins