title: Mapping of the human adenylosuccinate lyase (ADSL) gene to chromosome 22q13.1-->q13.2.
abstract: Adenylosuccinate lyase (ADSL) is an essential enzyme involved in de novo purine biosynthesis. A deficiency in ADSL in humans has been shown to predispose to a neurodevelopmental syndrome with autistic features. Using both a somatic cell hybrid mapping panel and fluorescence in situ hybridization, we have precisely localized the human ADSL gene to chromosome 22q13.1-->q13.2.
authors.affiliation: Montreal General Hospital Research Institute, McGill University, Québec, Canada.
authors.forename: E A
authors.initials: EA
authors.lastname: Fon
authors.forename: S
authors.initials: S
authors.lastname: Demczuk
authors.forename: O
authors.initials: O
authors.lastname: Delattre
authors.forename: G
authors.initials: G
authors.lastname: Thomas
authors.forename: G A
authors.initials: GA
authors.lastname: Rouleau
mesh_terms: D000264:Adenylosuccinate Lyase / Q000235:genetics*; D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D012377:Rodentia
chemical_list: D000264:Adenylosuccinate Lyase