title: Iodixanol in cardioangiography in patients with coronary artery disease. Tolerability, cardiac and renal effects.
abstract: Iodixanol is a new nonionic, dimeric contrast medium. With the addition of 18 mmol/l Na+ and 0.3 mmol/l Ca++ to iodixanol 320 mg I/ml a plasma-isotonic solution was obtained. The purpose was to evaluate the suitability of iodixanol for use in cardioangiography by determining the diagnostic efficacy, patient tolerability, and cardiac and renal side-effects. Initially, 14 patients with coronary artery disease were examined using iodixanol. A double-blind, randomized study was then performed in 72 patients, comparing iodixanol and iohexol. Serum and urine were sampled before the examination, and one and 2 days after. The diagnostic information was good and the number of adverse events low with iodixanol. The patients reported significantly less of a sensation of warmth following injection of iodixanol than iohexol. Our results also indicate that iodixanol 320 mg I/ml influences renal function to a lesser degree than does iohexol 350 mg I/ml. We therefore conclude that isotonic iodixanol is a safe contrast medium for use in cardioangiography.
authors.affiliation: Department of Radiology, National Hospital, Oslo, Norway.
authors.forename: N E
authors.initials: NE
authors.lastname: Kløw
authors.forename: K
authors.initials: K
authors.lastname: Levorstad
authors.forename: K J
authors.initials: KJ
authors.lastname: Berg
authors.forename: U
authors.initials: U
authors.lastname: Brodahl
authors.forename: K
authors.initials: K
authors.lastname: Endresen
authors.forename: D T
authors.initials: DT
authors.lastname: Kristoffersen
authors.forename: B
authors.initials: B
authors.lastname: Laake
authors.forename: S
authors.initials: S
authors.lastname: Simonsen
authors.forename: A J
authors.initials: AJ
authors.lastname: Tofte
authors.forename: B
authors.initials: B
authors.lastname: Lundby
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects; D008875:Middle Aged; D014283:Triiodobenzoic Acids / Q000009:adverse effects
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C044834:iodixanol