title: Nedocromil sodium in the prevention of exercise-induced bronchospasm in athletes with asthma.
abstract: The aim of this study was to determine the efficacy of nedocromil sodium in the prevention of exercise-induced bronchospasm (EIB) in 13 top athletes affected by bronchial asthma. At a dose of 4 mg the drug significantly reduced the fall in FEV1 compared with placebo but not with respect to basal values. In 9 athletes, 4 mg nedocromil sodium produced a good protective effect and reduced the mean fall in FEV1 to 4% with respect to baseline values, while in the remaining 4 subjects, the protective effect was not satisfactory. In these 4 "non responders" 6 mg nedocromil was effective, and in 2 cases induced prolonged bronchodilatation. In conclusion, the effect of nedocromil sodium in the prevention of EIB may be dose-dependent in relation to the degree of bronchial hyperreactivity or to interference of other factors.
authors.affiliation: Institute of Sport Science, Italian National Olymphic Committee, Rome.
authors.forename: A
authors.initials: A
authors.lastname: Todaro
authors.forename: M
authors.initials: M
authors.lastname: Faina
authors.forename: B
authors.initials: B
authors.lastname: Alippi
authors.forename: A
authors.initials: A
authors.lastname: Dal Monte
authors.forename: F
authors.initials: F
authors.lastname: Ruggieri
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000517:prevention & control*; D001642:Bicycling / Q000502:physiology; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D017835:Nedocromil / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D012146:Rest / Q000502:physiology; D012420:Running / Q000502:physiology; D013177:Sports / Q000502:physiology*; D013550:Swimming / Q000502:physiology; D013997:Time Factors
chemical_list: D010919:Placebos; D017835:Nedocromil