Endogenous gamma interferon mediates resistance to Brucella abortus infection.
Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection.
Zhan
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Y
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
Cheers
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C
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002003:Brucella abortus; D002006:Brucellosis / Q000276:immunology*; D007113:Immunity, Innate; D016219:Immunotherapy, Adoptive; D007371:Interferon-gamma / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D007371:Interferon-gamma