Polyamine acetylation in rat liver following long-term ethanol ingestion.
The effect of ethanol on polyamine acetylation was studied in rat liver. Animals were fed on nutritionally complete liquid diets with 36% or 12% of total calories supplied as ethanol or isocaloric carbohydrates for 4 months. The diet with 36% calories as ethanol significantly increased the activity of cytosolic spermidine/spermine N1-acetyltransferase, the rate-limiting enzyme in polyamine interconversion. Such a stimulation did not appear in rats under the 12% ethanol regimen. The stimulation of spermidine/spermine N1-acetyltransferase was associated with increases in putrescine and spermidine concentrations, an appearance of N1-acetylspermidine, and a decrease in spermine. These results suggest that chronic ethanol intake stimulates the acetylation of polyamines and their interconversion in rat liver.
Perin
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Centro di Studio sulla Patologia Cellulare, C.N.R., Università di Milano, Italy.
Sessa
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D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000428:Alcohol Drinking / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000378:metabolism*; D008297:Male; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013095:Spermidine / Q000031:analogs & derivatives / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D000099228:Diamine N-Acetyltransferase
D000123:Acetyltransferases; D011073:Polyamines; D011700:Putrescine; D013095:Spermidine; D013096:Spermine; D000099228:Diamine N-Acetyltransferase; C017988:N(1)-acetylspermidine