Thromboxane synthetase inhibition as a new therapy for preeclampsia: animal and human studies minireview.
The role of the eicosanoids in the pathophysiology of preeclampsia is reviewed, and the results of animal model and human studies with thromboxane synthetase inhibitors in preeclampsia are described. Potential benefits and limitations of therapy are discussed.
Keith
J C
JC
Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061.
Spitz
B
B
Van Assche
F A
FA
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D012756:Sheep; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D013930:Thromboxane-A Synthase