title: Intraoperative and external preoperative radiotherapy in invasive bladder cancer: effect of neoadjuvant chemotherapy in tumor downstaging.
abstract: Absence of residual cancer (pT0) in the cystectomy specimen was evaluated in patients with invasive bladder cancer treated with intraoperative (IORT) (15 Gy) and preoperative external beam radiotherapy (EBR) (46 Gy/5 weeks) with or without neoadjuvant chemotherapy. The overall pT0 rate was 68% (67% and 70% in patients with or without neoadjuvant chemotherapy, respectively). The tolerance to the program was acceptable in both groups. It is concluded that intense, combined modality treatment is feasible in bladder cancer patients, and the addition of neoadjuvant chemotherapy does not increase the morbidity. Preliminary results on disease-free survival are encouraging.
authors.affiliation: Division of Radiation Oncology, School of Medicine, University of Navarra, Pamplona, Spain.
authors.forename: F A
authors.initials: FA
authors.lastname: Calvo
authors.forename: J J
authors.initials: JJ
authors.lastname: Aristu
authors.forename: O
authors.initials: O
authors.lastname: Abuchaibe
authors.forename: J
authors.initials: J
authors.lastname: Rebollo
authors.forename: O
authors.initials: O
authors.lastname: Fernandez Hidalgo
authors.forename: J
authors.initials: J
authors.lastname: Zudaire
authors.forename: J M
authors.initials: JM
authors.lastname: Berian
authors.forename: I
authors.initials: I
authors.lastname: Azinovic
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery