Successful treatment of severe refractory sulfonylurea-induced hypoglycemia with octreotide.
OBJECTIVE
To test the clinical use of octreotide in the treatment of sulfonylurea-induced hypoglycemia.


METHODS
A case is reported of sulfonylurea-induced hypoglycemic coma in a nondiabetic subject, which was complicated by relapse of hypoglycemia after resuscitation with intravenous dextrose. Subcutaneous octreotide, 50 micrograms 12 hourly, suppressed stimulated endogenous insulin secretion, thereby preventing a further recurrence of hypoglycemia.


RESULTS
No adverse effects of treatment were observed.


CONCLUSIONS
These results suggest a significant role for octreotide as an adjunct to intravenous dextrose in the management of severe and refractory cases of sulfonylurea-induced hypoglycemia.
Krentz
A J
AJ
Diabetic Clinic, General Hospital, Birmingham, United Kingdom.
Boyle
P J
PJ
Justice
K M
KM
Wright
A D
AD
Schade
D S
DS
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D014044:Tolbutamide / Q000009:adverse effects*
D001786:Blood Glucose; D002096:C-Peptide; D014044:Tolbutamide; D015282:Octreotide