[Bone histomorphometric study of the ilium in psychiatric patients with longterm administration of anti-psychiatric drugs].
Histomorphometric studies were performed on biopsies of the spongiosa from the iliac crest of patients with fracture who had been taking medication for a psychiatric condition. The biopsy had been performed in 30 individuals, 10 of which were males and 20 females, ages ranging from 23 to 63 years, and from 21 to 75 respectively. Twenty healthy individuals were use as control. All anti-psychiatric drugs in this study have been calculated in terms of chlorpromazine (CPZ). The purpose of the study and intraoperative biopsy had been explained to the patients and their agreements were obtained before the surgery. The undecalcified specimen made from the iliac crest were studied using a semiautomatic image analyzer. In the result of this study, there was decrease in the bone volume (BV/TV), the osteoid surface (OS/BS), and the eroded surface (ES/BS) in the affected subjects compared to the controlled group. However, there was increase in the relative osteoid volume (OV/BV) among the subjects who had had a psychiatric condition for 21 years or more and taking more than 500 x 10(4) mg of CPZ. There was no significant difference in the mineral apposition rate (MAR) between the dosage of CPZ and periods of intake; however the MAR was elevated in the affected group as compared to the controlled group. In conclusion, prolonged administration of CPZ may increase the volume of osteoid and disturb the calcification.
Kutsuma
K
K
Department of Orthopedic Surgery, Kyorin University, School of Medicine, Tokyo, Japan.
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002113:Calcification, Physiologic / Q000187:drug effects; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007085:Ilium / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002746:Chlorpromazine