title: High-performance liquid chromatographic method for the determination of dimethindene in urine.
abstract: An automated high-performance liquid chromatographic assay, using on-line solid-phase extraction, is described for the determination of dimethindene in urine. The solid-phase extraction of the sample (1000 microliters) and the elution of the drug on to the analytical column are performed automatically and concomitantly. The limit of quantification is 5 pmol/ml.
authors.affiliation: Department of Toxicology and Pharmacokinetics, Zyma SA, CH-1260, Nyon, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Chollet
authors.forename: P
authors.initials: P
authors.lastname: Künstner
authors.forename: M
authors.initials: M
authors.lastname: Wermeille
mesh_terms: D001331:Automation; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004115:Dimethindene / Q000652:urine*; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004115:Dimethindene