title: Focal brain invasion as the first manifestation of Langerhans cell histiocytosis in an adult. Case report.
abstract: A 31-year-old overweight man, suffering from high-blood pressure, was hospitalized for transient fits and hemiparesis. MRI disclosed a large irregular mass affecting the vault, meninges and invading the parietal lobe. At neurosurgery, the lesion was necrotic, hemorrhagic and poorly demarcated from the surrounding brain. Histopathology revealed a benign Langerhans cell histiocytosis. No other systemic nor organic lesions could be discovered. After additional local radiotherapy, the patient recovered completely and regained normal activities 6 months later.
authors.affiliation: Department of Neuropathology, University of Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Reznik
authors.forename: A
authors.initials: A
authors.lastname: Stevenaert
authors.forename: V
authors.initials: V
authors.lastname: Bex
authors.forename: E
authors.initials: E
authors.lastname: Kratzenberg
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male