title: ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats.
abstract: The administration of rANP(1-28) in doses of 1.0 and 2.0 nmol (but not 0.2 nmol) into the lateral cerebral ventricle (i.c.v) of rats preliminarily kindled with picrotoxin resulted in an increase of the severity of picrotoxin-kindled convulsions 24 hrs after injection of the peptide. I.c.v. injection of pBNP(1-32) also resulted in a proepileptic effect when it was applied in the same doses with a similar time course; the increased seizure severity was observed 48 hrs after injection of pBNP in a dose of 2 nmol. I.c.v. administration of CNP(1-22) in a dose of 2 nmol induced an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide. None of the peptides influenced the seizure syndrome immediately after the injections. It is presumed that the delayed proepileptic properties of the three natriuretic peptides could be caused by some of their stable fragments which accumulate during their metabolism.
authors.affiliation: Institute of Pathophysiology, A. Szent-Gyorgyi Medical University, Szeged, Hungary.
authors.forename: A M
authors.initials: AM
authors.lastname: Mazarati
authors.forename: E
authors.initials: E
authors.lastname: Halászi
authors.forename: G
authors.initials: G
authors.lastname: Telegdy
authors.forename: G
authors.initials: G
authors.lastname: Tóth
authors.forename: J
authors.initials: J
authors.lastname: Varga
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D010852:Picrotoxin; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009320:Atrial Natriuretic Factor; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; D009419:Nerve Tissue Proteins; D010852:Picrotoxin