title: Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis.
abstract: The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients.
authors.affiliation: Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Taphoorn
authors.forename: E
authors.initials: E
authors.lastname: van Someren
authors.forename: F J
authors.initials: FJ
authors.lastname: Snoek
authors.forename: R L
authors.initials: RL
authors.lastname: Strijers
authors.forename: D F
authors.initials: DF
authors.lastname: Swaab
authors.forename: F
authors.initials: F
authors.lastname: Visscher
authors.forename: L P
authors.initials: LP
authors.lastname: de Waal
authors.forename: C H
authors.initials: CH
authors.lastname: Polman
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm / Q000502:physiology; D003866:Depressive Disorder / Q000209:etiology / Q000503:physiopathology; D005221:Fatigue / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D011930:Reaction Time; D012893:Sleep Wake Disorders / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*
chemical_list: D006680:HLA Antigens