title: Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.
abstract: The autosomal recessive scid mutation results in defective immunoglobulin and T cell receptor gene rearrangement. The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T cells and immunoglobulin, a phenotype known as "leaky." Moreover, introduction of neonatal T cells into C.B-17 scid mice leads to immunoglobulin production by 100% of animals. We have produced mice homozygous for both the scid and beige mutations. By contrast with C.B-17 scid mice, BALB/c scid.beige mice have a < 2% incidence of "leakiness." This percentage does not increase with age, and introduction of neonatal T cells fails to rescue immunoglobulin production. This suggests that a gene (or genes) closely linked to the beige locus regulates B and/or T cell development.
authors.affiliation: Division of Immunology, Medical Biology Institute, La Jolla, California 92137.
authors.forename: D E
authors.initials: DE
authors.lastname: Mosier
authors.forename: K L
authors.initials: KL
authors.lastname: Stell
authors.forename: R J
authors.initials: RJ
authors.lastname: Gulizia
authors.forename: B E
authors.initials: BE
authors.lastname: Torbett
authors.forename: G L
authors.initials: GL
authors.lastname: Gilmore
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001402:B-Lymphocytes / Q000502:physiology*; D005803:Genes, Immunoglobulin; D006720:Homozygote; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID / Q000235:genetics*; D009154:Mutation; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D007075:Immunoglobulin M