Increased expression of Fc gamma RI on isolated PMN from individuals of African descent.
Fc gamma R plays an important role in host defense, triggering and/or facilitating many immunologic responses. Of the three defined Fc gamma Rs, Fc gamma RI (CD64) is not known to be constitutively expressed on normal PMN. We report here that there is markedly increased expression of Fc gamma RI on the PMN of normal, healthy blacks, detected by binding of monoclonal antibody to this receptor. This may have significant implications when multiracial data are pooled in studies of receptor expression as markers of response to various chemotherapeutic agents.
Moxey-Mims
M M
MM
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Frank
M M
MM
Lin
E Y
EY
Francis
C
C
Gaither
T A
TA
D000349:Africa / Q000208:ethnology; D000911:Antibodies, Monoclonal / Q000378:metabolism; D001665:Binding Sites; D044383:Black People; D017691:Caribbean Region / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000276:immunology / Q000648:ultrastructure*; D017452:Receptors, IgG / Q000378:metabolism / Q000502:physiology*; D044465:White People
D000911:Antibodies, Monoclonal; D017452:Receptors, IgG