Indomethacin and recurrent ileal perforations in a preterm infant.
This article reports a case of a very low birth weight infant who was given intravenous indomethacin for a symptomatic patent ductus arteriosus and subsequently had two isolated ileal perforations several days apart. Spontaneous or indomethacin-related ileal perforation appears to constitute a separate clinical and pathologic entity, different from necrotizing enterocolitis, with a benign clinical picture and good prognosis when promptly recognized.
Giacoia
G P
GP
Department of Pediatrics, University of Oklahoma College of Medicine, Tulsa.
Azubuike
K
K
Taylor
J R
JR
D004374:Ductus Arteriosus, Patent / Q000188:drug therapy; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced*; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007416:Intestinal Perforation / Q000139:chemically induced*; D008297:Male; D012008:Recurrence
D007213:Indomethacin