title: Cloning and characterization of human TNF alpha promoter region.
abstract: We report the sequence of a 1.2-kb human tumor necrosis factor alpha (TNF alpha) promoter region, which was cloned using PCR. The sequence has several variations from two previous reports and exhibits many potential DNA-binding sites specific to mammalian gene regulatory proteins inducible by lipopolysaccharides.
authors.affiliation: Department of Periodontology, Eastman Dental Center, Rochester, NY 14620.
authors.forename: S
authors.initials: S
authors.lastname: Takashiba
authors.forename: L
authors.initials: L
authors.lastname: Shapira
authors.forename: S
authors.initials: S
authors.lastname: Amar
authors.forename: T E
authors.initials: TE
authors.lastname: Van Dyke
mesh_terms: D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D004247:DNA