Effects of pentoxifylline on sperm motility and hyperactivated motility in vitro: a preliminary report.
Previous reports (2, 3) have suggested that pentoxifylline increases sperm motility. In this preliminary report based on five asthenozoospermic and five normal motility semen samples, we were unable to demonstrate any statistically significant effect of pentoxifylline on percent motility of human spermatozoa. However, in vitro exposure to capacitation medium with pentoxifylline may lead to an increase in total hyperactivated motility in asthenozoospermic samples, an effect not evident in the normal motility samples in this study.
Pang
S C
SC
Division of Reproductive Endocrinology/Infertility, University of California, Los Angeles School of Medicine/Cedars-Sinai Medical Center.
Williams
D B
DB
Huang
T
T
Wang
C
C
D006801:Humans; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D012016:Reference Values; D013075:Sperm Capacitation / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects*
D010431:Pentoxifylline