title: Abnormalities in T cell interactions with the extracellular matrix proteins in a patient with Wegener's granulomatosis.
abstract: T cell interactions with the extracellular matrix proteins and cultured human endothelium were studied in a patient with Wegener's granulomatosis and other cases of vasculitis. Markedly enhanced costimulation of T-lymphoproliferative responses mediated by collagen and fibronectin were found in patients with severe forms of vasculitis, particularly with necrotizing changes. In addition, enhanced adhesion to collagen IV was found in the Wegener patient. T cell adhesion to resting and inflamed endothelium varied from normal to increased.
authors.affiliation: Department of Immunology, Warsaw Medical School, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Górski
authors.forename: J
authors.initials: J
authors.lastname: Piekarczyk
authors.forename: H
authors.initials: H
authors.lastname: Skurzak
authors.forename: M
authors.initials: M
authors.lastname: Nowaczyk
authors.forename: B
authors.initials: B
authors.lastname: Dybowska
authors.forename: B
authors.initials: B
authors.lastname: Stepień-Sopniewska
authors.forename: G
authors.initials: G
authors.lastname: Korczak-Kowalska
authors.forename: J
authors.initials: J
authors.lastname: Pazdur
authors.forename: A
authors.initials: A
authors.lastname: Filipowicz-Sosnowska
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002478:Cells, Cultured; D003094:Collagen / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D005260:Female; D005353:Fibronectins / Q000502:physiology; D014890:Granulomatosis with Polyangiitis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D008213:Lymphocyte Activation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D014657:Vasculitis / Q000276:immunology / Q000473:pathology
chemical_list: D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D003094:Collagen