Effect of aging in human cortical pre- and postsynaptic serotonin binding sites.
5-HT1A, 5-HT1D, 5-HT2 binding sites and affinity and 5-HT uptake sites were simultaneously determined in frontal cortex samples from 23 control subjects, aged 16-75 years. A significant reduction in the number of 5-HT1D and 5-HT2 binding sites was found with regard to age, together with a significant decrease in the 5-HT2 binding affinity. It is suggested that the total 5-HT1 age-related loss described in previous studies could be ascribed to the 5-HT2 subtype. Furthermore, aging does not seem to be associated with a reduced cortical serotonergic innervation, as indicated by the stability of the [3H]paroxetine-labeled 5-HT uptake sites.
Arranz
B
B
Department of Geriatric Medicine, University of Linköping, Sweden.
Eriksson
A
A
Mellerup
E
E
Plenge
P
P
Marcusson
J
J
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001665:Binding Sites; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D007650:Ketanserin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000378:metabolism; D011869:Radioligand Assay; D012701:Serotonin / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
D012701:Serotonin; D017374:Paroxetine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin