The 39-kilodalton outer membrane protein of Proteus mirabilis is an OmpA protein and mitogen for murine B lymphocytes.
Partial amino acid sequence analysis of a major outer membrane protein of Proteus mirabilis (39-kDa protein) indicates that it is an OmpA protein. The mitogenic activities of the 39-kDa protein for murine lymphocytes were also investigated with T lymphocytes isolated by passing spleen cells over columns of nylon wool fiber and B lymphocytes obtained by treating spleen cells with monoclonal antibodies to Thy1 plus complement. The 39-kDa protein showed little activity in stimulating T cells to proliferate but was strongly mitogenic for B cells.
Korn
A
A
Department of Microbiology, University of Darmstadt, Germany.
Kroll
H P
HP
Berger
H P
HP
Kahler
A
A
Hessler
R
R
Brauburger
J
J
Müller
K P
KP
Nixdorff
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D011513:Proteus mirabilis / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D001425:Bacterial Outer Membrane Proteins; D008934:Mitogens