Nasal mucosal congestion after treatment with bromocriptine.
Nine women were given bromocriptine a few days after delivery in order to inhibit lactation. Nasal airway resistance to airflow (NAR) was recorded and blood samples were taken before treatment with bromocriptine, 2 to 3 hours after the first dose of this drug, and after 3 to 5 days on this treatment. All the women had increased nasal congestion after bromocriptine and NAR rose significantly. The prolactin, estradiol, and progesterone hormone levels decreased significantly, but no significant difference was found in the levels of thyroid-stimulating hormone (TSH) and vasoactive intestinal polypeptide (VIP). The bromocriptine effect may be caused by different mechanisms.
Bende
M
M
Department of Otolaryngology, Central Hospital, Skövde, Sweden.
Bergman
B
B
Sjögren
C
C
D000328:Adult; D000403:Airway Resistance; D001971:Bromocriptine / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects; D009296:Nasal Cavity / Q000502:physiology; D009297:Nasal Mucosa / Q000098:blood supply / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014660:Vasoactive Intestinal Peptide / Q000097:blood; D014664:Vasodilation / Q000187:drug effects
D014660:Vasoactive Intestinal Peptide; D001971:Bromocriptine; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D013972:Thyrotropin