Continuous 5-fluorouracil infusion causing acute gastric mucosal lesions.
A 59-year-old woman with advanced gastric cancer was treated with continuous 5-fluorouracil infusion for thirty-five days. Endoscopy of the upper gastrointestinal tract was performed due to continuing nausea seven days after the cessation of 5-fluorouracil infusion and revealed multiple erosions in the antrum which were absent before chemotherapy. Continuous 5-fluorouracil infusion was probably the cause of acute gastric mucosal lesions and should be included in the differential diagnosis of dyspepsia in 5-FU-treated patients.
Suda
K
K
Department of Medical Oncology, Tochigi Cancer Center, Utsunomiya, Japan.
Seki
T
T
Kano
Y
Y
Sasagawa
M
M
D000230:Adenocarcinoma / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005756:Gastritis / Q000139:chemically induced*; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013997:Time Factors
D005472:Fluorouracil