title: Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging.
abstract: A new cationic complex, [99mTc(tetrofosmin)2O2]+, where tetrofosmin is the ether functionalized diphosphine ligand 1,2-bis[bis(2-ethoxyethyl)phosphino]ethane, has been synthesized and evaluated for potential use in myocardial perfusion imaging. The structure of the complex has been determined by x-ray crystallography of the 99Tc analog. In comparison with previously reported 99mTc complexes of alkyl-phosphines, the tetrofosmin species shows substantially increased clearance from nontarget tissue, especially blood and liver. A freeze-dried kit formulation has been developed. The kit provides a product of high radiochemical purity up to 8 hr after reconstitution at room temperature.
authors.affiliation: Pharmaceuticals Research and Development, Amersham International plc, Buckinghamshire, United Kingdom.
authors.forename: J D
authors.initials: JD
authors.lastname: Kelly
authors.forename: A M
authors.initials: AM
authors.lastname: Forster
authors.forename: B
authors.initials: B
authors.lastname: Higley
authors.forename: C M
authors.initials: CM
authors.lastname: Archer
authors.forename: F S
authors.initials: FS
authors.lastname: Booker
authors.forename: L R
authors.initials: LR
authors.lastname: Canning
authors.forename: K W
authors.initials: KW
authors.lastname: Chiu
authors.forename: B
authors.initials: B
authors.lastname: Edwards
authors.forename: H K
authors.initials: HK
authors.lastname: Gill
authors.forename: M
authors.initials: M
authors.lastname: McPartlin
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000000981:diagnostic imaging*; D008297:Male; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000633:toxicity; D015609:Organotechnetium Compounds / Q000737:chemistry* / Q000633:toxicity; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D013552:Swine; D013556:Swine, Miniature; D014018:Tissue Distribution
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin