title: Wilson's disease: evidence of subgroups derived from clinical findings and brain lesions.
abstract: Using exploratory factor analysis, we prospectively investigated neuropsychiatric symptoms and structural brain lesions of 47 patients with proven Wilson's disease and identified three subgroups. The first subgroup clinically exhibited bradykinesia, rigidity, cognitive impairment, and an organic mood syndrome and by MRI showed a dilatation of the third ventricle. The second subgroup was characterized by ataxia, tremor, reduced functional capacity, and focal thalamic lesions. The third subgroup showed dyskinesia, dysarthria, an organic personality syndrome, and focal lesions in the putamen and in the pallidum.
authors.affiliation: Neurologische Universitätsklinik, University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Oder
authors.forename: L
authors.initials: L
authors.lastname: Prayer
authors.forename: G
authors.initials: G
authors.lastname: Grimm
authors.forename: J
authors.initials: J
authors.lastname: Spatt
authors.forename: P
authors.initials: P
authors.lastname: Ferenci
authors.forename: H
authors.initials: H
authors.lastname: Kollegger
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: A
authors.initials: A
authors.lastname: Gangl
authors.forename: L
authors.initials: L
authors.lastname: Deecke
mesh_terms: D000293:Adolescent; D000328:Adult; D001259:Ataxia / Q000175:diagnosis; D001921:Brain / Q000473:pathology; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis; D005163:Factor Analysis, Statistical; D005260:Female; D006527:Hepatolenticular Degeneration / Q000145:classification* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011446:Prospective Studies; D014202:Tremor / Q000175:diagnosis