Study of blood compatible polymers. III. Copolymers of N-benzyl, N-(2-hydroxyethyl) acrylamide and 2-hydroxyethyl methacrylate.
Copolymerization of 2-hydroxyethyl methacrylate (HEMA) and N-benzyl, N-(2-hydroxyethyl) acrylamide (BENAAm) was carried out at different mole ratios of the monomers to obtain copolymers of varying composition. BENAAm content of the copolymers varies between 13 and 70%. Investigation of the interaction of rabbit platelets with these polymer surfaces showed that copolymers with higher BENAAm content inhibit the platelet deformation. Human umbilical cord fibroblast cells proliferated very well on the copolymer surfaces. The cell growth rate on polyHEMA was relatively low. Maximum cell growth was observed on the copolymer having 87% HEMA.
Mathew
J
J
Department of Bio-engineering, Research Institute for Polymers and Textiles, Ibaraki, Japan.
Liu
S Q
SQ
Kodama
M
M
D000180:Acrylic Resins; D000818:Animals; D001672:Biocompatible Materials; D001769:Blood; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D011102:Polyhydroxyethyl Methacrylate; D011817:Rabbits
D000180:Acrylic Resins; D001672:Biocompatible Materials; D011102:Polyhydroxyethyl Methacrylate