title: High-frequency ventilation for acute pediatric respiratory failure.
abstract: OBJECTIVE
  To study the effectiveness of high-frequency ventilation (HFV) for the treatment of pediatric patients with acute severe respiratory failure.
  
  
  METHODS
  Post hoc analysis of retrospectively and prospectively acquired data.
  
  
  METHODS
  Tertiary pediatric ICU.
  
  
  METHODS
  Twelve patients, ages 4 months to 15 years, who developed acute severe respiratory failure from diverse causes.
  
  
  METHODS
  Patients were treated with synchronized intermittent mandatory ventilation (SIMV) using moderate positive end-expiratory pressure (PEEP) and supplemental oxygen prior to HFV therapy. Ten of 12 patients required one or more medications to modulate preload, inotropy, and/or afterload. All patients were invasively monitored for arterial BP and arterial blood gases, and they were noninvasively monitored for oxygen saturation, end tidal or transcutaneous carbon dioxide, and electrocardiography.
  
  
  RESULTS
  Severity of respiratory failure was reflected by median values of pH of 7.34, lung compliance of 0.41 ml/cm H2O/kg, P(A-a)O2 of 553 mm Hg, oxygenation index (OI) of 28, and ventilation index of 102. Significant improvement in pH, PaCO2, PaO2, OI, and P(A-a)O2 was demonstrated early in the course of HFV (p < 0.05). Seven of the patients (58 percent) were survivors.
  
  
  CONCLUSIONS
  These data suggest that HFV may offer significant benefit as a rescue modality for patients with severe respiratory failure refractory to SIMV strategies early in the course of the disease process.
authors.affiliation: Department of Pediatrics, Ohio State University, Columbus.
authors.forename: R B
authors.initials: RB
authors.lastname: Rosenberg
authors.forename: C W
authors.initials: CW
authors.lastname: Broner
authors.forename: K J
authors.initials: KJ
authors.lastname: Peters
authors.forename: D L
authors.initials: DL
authors.lastname: Anglin
mesh_terms: D000208:Acute Disease; D002648:Child; D005260:Female; D006612:High-Frequency Ventilation; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies