Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain.
The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M1-receptor messenger RNA (M1-R mRNA) in the rat striatum were studied. Carbachol increased the M1-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.
Chou
H
H
Department of Neuroscience, Okayama University Medical School, Japan.
Ogawa
N
N
Asanuma
M
M
Hirata
H
H
Kondo
Y
Y
Mori
A
A
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002217:Carbachol / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000235:genetics*; D013997:Time Factors; D014282:Trihexyphenidyl / Q000494:pharmacology
D012333:RNA, Messenger; D011976:Receptors, Muscarinic; D014282:Trihexyphenidyl; D002217:Carbachol