Pharmacokinetics of diphemanil methylsulphate in infants.
The pharmacokinetics of diphemanil methylsulphate was evaluated after oral administration of a single 3 mg.kg-1 dose to 5 infants being treated for symptomatic bradycardia. The mean pharmacokinetic parameters of oral diphemanil methylsulphate in infants were similar to those in adults. The mean half-life was 8.6 h. This would allow administration three times a day in infants instead of four to six times a day, as currently prescribed. The mean residence time decreases significantly with age (Spearman's r' = -1), and there is a trend for the half-life to decrease with age (r' = -0.9; NS), suggesting an influence of maturation on its elimination.
Vidal
A M
AM
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
Chéron
G
G
Rey
E
E
Pons
G
G
d'Athis
P
P
Olive
G
G
D000284:Administration, Oral; D001919:Bradycardia / Q000188:drug therapy / Q000378:metabolism; D004334:Drug Administration Schedule; D006207:Half-Life; D006801:Humans; D007223:Infant; D010276:Parasympatholytics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
D010276:Parasympatholytics; D010880:Piperidines; C028209:diphemanil methylsulfate