title: Protective effect of triflusal against acute myocardial infarction in patients with unstable angina: results of a Spanish multicenter trial. Grupo de Estudio del Triflusal en la Angina Inestable.
abstract: A multicenter, double-blind, placebo-controlled study was carried out to evaluate the effect of a new antiplatelet agent, triflusal (2-acetoxy-4-trifluoromethyl benzoic acid), in the prevention of nonfatal myocardial infarction and cardiac or vascular death (principal end-points) in patients with unstable angina. 281 patients were randomly assigned to triflusal (300 mg t.i.d.; n = 143) or placebo (n = 138). After 6 months of treatment, the incidence of nonfatal acute myocardial infarction was significantly lower in the triflusal than in the placebo group: 6 patients (4.2%) versus 17 (12.3%), p = 0.013. The low number of deaths (2/143 triflusal versus 0/138 placebo recipients) hampered statistical analysis of mortality rates. The need for revascularization was similar in the two groups: 24 patients (16.8%) in the triflusal group and 28 (20.3%) in the placebo group, p = 0.449. In conclusion, the results show that treatment with triflusal can reduce the incidence of myocardial infarction in patients with unstable angina.
authors.affiliation: Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Plaza
authors.forename: L
authors.initials: L
authors.lastname: López-Bescós
authors.forename: L
authors.initials: L
authors.lastname: Martín-Jadraque
authors.forename: E
authors.initials: E
authors.lastname: Alegría
authors.forename: J M
authors.initials: JM
authors.lastname: Cruz-Fernández
authors.forename: J
authors.initials: J
authors.lastname: Velasco
authors.forename: J A
authors.initials: JA
authors.lastname: Ruipérez
authors.forename: F
authors.initials: F
authors.lastname: Malpartida
authors.forename: A
authors.initials: A
authors.lastname: Artal
authors.forename: A
authors.initials: A
authors.lastname: Cabadés
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000789:Angina, Unstable / Q000188:drug therapy* / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality / Q000517:prevention & control*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use*; D013030:Spain; D015996:Survival Rate
chemical_list: D010975:Platelet Aggregation Inhibitors; D012459:Salicylates; C016167:triflusal