Protection of intestinal anastomoses by biodegradable intraluminal bypass tubes under the condition of general peritonitis: an experimental study on the CLP model in rats.
The purpose of this experimental study was to affirm the protective effect of biodegradable tubes for the intraluminal bypass procedure under the adverse condition of general peritonitis. General peritonitis was induced by means of the cecal ligation and puncture (CLP) model in the rat. The leakage rate in the control group (n = 20) without anastomotic protection was 70 percent (14/20). In three therapeutic groups, each consisting of 20 animals, the intestinal anastomoses were protected by an intraluminal bypass tube of different biodegradable biomaterials (collagen-II, BCL-002, and BCL-004). The best results were noted in the collagen-II and BCL-002 groups, where the leakage rates could be reduced to 10 percent. These highly significant results (P = 0.0001) prove the feasibility of biodegradable biomaterials for the intraluminal bypass procedure in the rat, even in cases with underlying peritonitis.
Winkeltau
G J
GJ
Department of Surgery, RWTH-Aachen, Germany.
Treutner
K H
KH
Kleimann
E
E
Lerch
M M
MM
Ger
R
R
Haase
G
G
Schumpelick
V
V
D000714:Anastomosis, Surgical / Q000295:instrumentation*; D000818:Animals; D001673:Biodegradation, Environmental; D002432:Cecum / Q000601:surgery; D004195:Disease Models, Animal; D004867:Equipment Design; D007422:Intestines / Q000601:surgery*; D008026:Ligation; D008297:Male; D010538:Peritonitis / Q000150:complications* / Q000382:microbiology; D011183:Postoperative Complications; D011677:Punctures; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015607:Stents