Pancreatic polypeptide stimulates corticosterone secretion by isolated rat adrenocortical cells.
Pancreatic polypeptide (PP) dose-dependently enhanced both basal and submaximally ACTH-stimulated corticosterone production by dispersed zona fasciculata/reticularis cells of the rat adrenal gland. Conversely PP did not affect either basal or ACTH- and angiotensin-II-stimulated aldosterone and corticosterone secretion of zona glomerulosa cells. These findings could throw light on the physiological significance of the marked increase in the pancreatic release of PP during stresses.
Andreis
P G
PG
Department of Anatomy, University of Padua, Italy.
Tortorella
C
C
Nussdorfer
G G
GG
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010191:Pancreatic Polypeptide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D015383:Zona Fasciculata / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D015385:Zona Reticularis / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*
D000804:Angiotensin II; D000450:Aldosterone; D010191:Pancreatic Polypeptide; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone