title: Studies on the relationship between hepatic and splenic density change in dynamic CT in the presence of a large splenorenal shunt in patients with liver cirrhosis.
abstract: Using dynamic computerized tomography (CT), we studied liver and spleen hemodynamics in one group of patients with a large splenorenal shunt and another group without a large shunt. Specifically, we measured the time-to-peak hepatic and splenic enhancement and the loss of enhancement, i.e., decay time. The time-to-peak liver enhancement (61 +/- 21 s vs. 81 +/- 14 s, p < 0.05) and the splenic decay time (24 +/- 16 s vs. 48 +/- 28 s, p < 0.05) were significantly shorter in patients with a large splenorenal shunt compared to those without. The groups had similar hepatic decay times and times to peak splenic enhancement. We found dynamic CT useful in assessing the effect of a large splenorenal shunt on portal and splenic hemodynamics.
authors.affiliation: Saiseikai Wakakusa Hospital, Yokohama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sugano
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Okajima
authors.forename: S
authors.initials: S
authors.lastname: Kubo
authors.forename: Y
authors.initials: Y
authors.lastname: Sumino
authors.forename: T
authors.initials: T
authors.lastname: Abei
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D012079:Renal Circulation; D013154:Spleen / Q000098:blood supply*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media