Absence of expression of interleukin-6 (IL-6) mRNA in regenerating rat liver.
The serum level of IL-6 and expression of IL-6 mRNA in hepatocytes from regenerating liver were investigated in the rat. The IL-6 level in the serum was not significantly different from that of a control group of rats submitted to an acute experimental inflammation. IL-6 mRNA expression did not occur in the liver of hepatectomized rats as judged from Northern blotting experiments using an IL-6 riboprobe. These results suggest that if IL-6 is implicated in hepatic regeneration, this cytokine is not produced by the regenerating liver and must be delivered exogenously to the liver to modulate hepatic regeneration.
Scotté
M
M
INSERM Unité 78, Bois-Guillaume, France.
Daveau
M
M
Hiron
M
M
Ténière
P
P
Lebreton
J P
JP
D000818:Animals; D015870:Gene Expression; D015850:Interleukin-6 / Q000235:genetics*; D008099:Liver / Q000502:physiology*; D008115:Liver Regeneration; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014425:Turpentine / Q000494:pharmacology
D015850:Interleukin-6; D012333:RNA, Messenger; D014425:Turpentine