title: An interaction of beta-amyloid with aluminium in vitro.
abstract: We have used circular dichroism spectroscopy to confirm that, in a membrane-mimicking solvent, A beta P(1-40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and beta-amyloid and may have important implications for the pathogenesis of Alzheimer's disease.
authors.affiliation: Department of Chemistry, Keele University, Staffordshire, UK.
authors.forename: C
authors.initials: C
authors.lastname: Exley
authors.forename: N C
authors.initials: NC
authors.lastname: Price
authors.forename: S M
authors.initials: SM
authors.lastname: Kelly
authors.forename: J D
authors.initials: JD
authors.lastname: Birchall
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002942:Circular Dichroism; D006801:Humans; D066298:In Vitro Techniques; D010455:Peptides / Q000737:chemistry; D017433:Protein Structure, Secondary
chemical_list: D016229:Amyloid beta-Peptides; D010455:Peptides; D000535:Aluminum