title: Periventricular haemorrhage in very low birth weight Malaysian neonates.
abstract: A prospective study was carried out to determine the incidence, clinical presentation, early outcome, and risk factors associated with periventricular haemorrhage (PVH) in 88 (84 per cent) of the 105 consecutive very low birth weight (VLBW) (< 1500 g) Malaysian neonates born in the Maternity Hospital, Kuala Lumpur. Based on the cranial ultrasound findings, PVH was detected in 86 of the 88 neonates (98 per cent, 95 per cent confidence intervals: 95 to 101). Seventeen (20 per cent) of them had grade I, 52 (61 per cent) had grade II, 7 (8 per cent) had grade III and 10 (12 per cent) had grade IV PVH. PVH was detected in all the affected neonates by the fifth day of life. Sixty-four neonates (74 per cent) were symptomatic when PVH was first detected. Shock (P < 0.01), pallor (P = 0.028), low haematocrit of less than 40 per cent (P < 0.01), convulsion (P < 0.001), and bulging of anterior fontanelle (P = 0.019) were significantly more common in the neonates with severe PVH (grades III or IV). Death occurred in 43/86 (50 per cent, 95 per cent confidence interval: 39-61 per cent) of the neonates with PVH before their first discharge from the hospital. Ventriculomegaly developed in 29/43 (67 per cent, 95 per cent confidence intervals: 54.4-81.4) of the survivors with PVH. Our study suggests that PVH is a common problem in the Malaysian VLBW neonates. To reduce the incidence and severity of this condition, prevention of preterm delivery and improvement in the basic facilities for neonatal care would help.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda, Kuala Lumpur.
authors.forename: N Y
authors.initials: NY
authors.lastname: Boo
authors.forename: L C
authors.initials: LC
authors.lastname: Ong
authors.forename: M S
authors.initials: MS
authors.lastname: Lye
authors.forename: K P
authors.initials: KP
authors.lastname: Wong
authors.forename: M
authors.initials: M
authors.lastname: Mastura
mesh_terms: D017668:Age of Onset; D001927:Brain Diseases / Q000175:diagnosis / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006293:Health Promotion; D006470:Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014463:Ultrasonography