title: Automated region definition for cardiac nitrogen-13-ammonia PET imaging.
abstract: In combination with PET, the tracer 13N-ammonia can be employed for the noninvasive quantification of myocardial perfusion at rest and after pharmacological stress. The purpose of this study was to develop an analysis method for the quantification of regional myocardial blood flow in the clinical setting. The algorithm includes correction for patient motion, an automated definition of multiple regions and display of absolute flows in polar map format. The effects of partial volume and blood to tissue cross-contamination were accounted for by optimizing the radial position of regions to meet fundamental assumptions of the kinetic model. In order to correct for motion artifacts, the myocardial displacement was manually determined based on edge-enhanced images. The obtained results exhibit the capability of the presented algorithm to noninvasively assess regional myocardial perfusion in the clinical environment.
authors.affiliation: Division of Nuclear Medicine, University of Michigan Hospitals, Ann Arbor 48109-0028.
authors.forename: O
authors.initials: O
authors.lastname: Muzik
authors.forename: R
authors.initials: R
authors.lastname: Beanlands
authors.forename: E
authors.initials: E
authors.lastname: Wolfe
authors.forename: G D
authors.initials: GD
authors.lastname: Hutchins
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
mesh_terms: D000328:Adult; D000641:Ammonia; D003326:Coronary Circulation; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009590:Nitrogen Radioisotopes; D014055:Tomography, Emission-Computed
chemical_list: D009590:Nitrogen Radioisotopes; D000641:Ammonia