Characterization of oil-in-water emulsions prepared from solid-state emulsions: effect of matrix and oil phase.
Emulsions (o/w) were prepared from solid-state emulsions comprised of various matrix materials and oils and the resultant particle size properties determined. Results suggest that for those matrices that can form solid-state emulsions, the droplet size decreased as a function of time, as previously observed. The final droplet size was dependent on the oil utilized but was independent of the matrix material. The use of mineral oil resulted in the smallest droplet diameter (approximately 1.5 microns) while isopropyl myristate resulted in the largest droplet diameter (approximately 3 microns). With the exception of mineral oil, the oil/water interfacial tension was found to be directly proportional to the droplet diameter. The rate of emulsification appeared to be biphasic. The initial emulsification phase appeared to be independent of the matrix material while the terminal phase was a function of the matrix material. Most importantly, it was found that solid state emulsions could be prepared from a diverse, yet specific, list of matrices.
Shively
M L
ML
University of Colorado Health Science Center, School of Pharmacy, Denver 80262.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004655:Emulsions; D005079:Excipients; D009821:Oils / Q000737:chemistry*; D010316:Particle Size; D013500:Surface Tension; D014867:Water / Q000737:chemistry*
D004655:Emulsions; D005079:Excipients; D009821:Oils; D014867:Water