Controlled delivery of pilocarpine. 1. In vitro characterization of Gelfoam matrices.
The potential of Gelfoam absorbable gelatin sponge as a carrier for ophthalmic delivery of pilocarpine was examined. Prolonged in vitro release of pilocarpine was achieved through pharmaceutical modification of the device by embedding a retardant in the pores. The device embedded with cetyl ester wax released pilocarpine in a zero-order pattern (release exponent = 0.93 +/- 0.04) for up to 5 hr. This result corresponded well with a linear penetrant uptake by this device. The device impregnated with polyethylene glycol 400 monostearate exhibited anomalous drug transport with a release exponent of 0.63 +/- 0.02. The absorption of water by this retardant and the formation of a gel layer on the surface slowed the penetration of the release medium into the deeper sections of the matrix, as well as the rapid outward diffusion of drug, resulting in a prolonged release of pilocarpine.
Nadkarni
S R
SR
Department of Pharmaceutical Sciences, University of Arizona, Tucson 85721.
Yalkowsky
S H
SH
D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D016503:Drug Delivery Systems; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D014885:Waxes
D009883:Ophthalmic Solutions; D014885:Waxes; D010862:Pilocarpine; D011092:Polyethylene Glycols