title: Indium-111-labelled antimyosin antibody imaging in a patient with cardiac sarcoidosis.
abstract: The aetiology of cardiac dysfunction caused by sarcoid granulomatous inflammation may be difficult to clarify, and the potential of imaging methods is limited. We report on a patient who presented with acute biventricular decompensation. Pulmonary sarcoidosis was confirmed after hospitalization. Four weeks after the initiation of corticosteroid treatment, scintigraphy with indium-111-labelled antimyosin antibody Fab fragments (AMAB) revealed distinct activity accumulation in major parts of the left ventricular wall (heart-lung ratio: 1.6) 72 h following injection. There may be a role for AMAB scintigraphy in the early detection of cardiac sarcoidosis.
authors.affiliation: Institute of Nuclear Medicine, University Hospital, Ruhr-Universität Bochum, Bad Oeynhausen, Federal Republic of Germany.
authors.forename: W H
authors.initials: WH
authors.lastname: Knapp
authors.forename: A
authors.initials: A
authors.lastname: Bentrup
authors.forename: H
authors.initials: H
authors.lastname: Ohlmeier
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D009202:Cardiomyopathies / Q000000981:diagnostic imaging*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D012507:Sarcoidosis / Q000000981:diagnostic imaging*
chemical_list: D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C058899:imciromab pentetate