Biospecific haemosorbents based on proteinase inhibitor. I. Synthesis and properties.
Sorbents for the removal of proteolytic enzymes from biological fluids were synthesized by immobilization of proteinase inhibitor, ovomucoid from duck egg white, in polymeric hydrogel matrix. The immobilization of the protein inhibitor modified by acryloyl chloride occurs during copolymerization of the unsaturated derivative of inhibitor with hydrophilic monomer and crosslinking agent. It was shown that the sorbent obtained possesses a high affinity for proteinases and is haemocompatible. The use of the haemosorbent for eliminating excess activated proteinase from blood is proposed.
Platé
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NA
Institute of Petrochemical Synthesis, Academy of Sciences, Moscow, Russia.
Valuev
L I
LI
Valueva
T A
TA
Chupov
V V
VV
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D010450:Endopeptidases / Q000097:blood / Q000302:isolation & purification; D005782:Gels; D006464:Hemoperfusion; D008422:Materials Testing; D010059:Ovomucin; D011480:Protease Inhibitors
D001672:Biocompatible Materials; D005782:Gels; D011480:Protease Inhibitors; D010059:Ovomucin; D010450:Endopeptidases