title: Clarithromycin-carbamazepine interaction: a case report.
abstract: We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin, and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10-day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ-E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.
authors.affiliation: Laboratory of Neuropharmacology, University of Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Albani
authors.forename: R
authors.initials: R
authors.lastname: Riva
authors.forename: A
authors.initials: A
authors.lastname: Baruzzi
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000493:pharmacokinetics / Q000494:pharmacology*; D017291:Clarithromycin / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy; D008297:Male
chemical_list: D002220:Carbamazepine; D017291:Clarithromycin