Clarithromycin-carbamazepine interaction: a case report.
We report a clinically relevant interaction between a new macrolide antibiotic, clarithromycin, and carbamazepine (CBZ). In a patient receiving CBZ monotherapy, 10-day antibiotic treatment increased CBZ concentration despite concomitant CBZ dose reduction and doubled the CBZ concentration/dose ratio. Concentration of the CBZ epoxide (CBZ-E) metabolite was reduced, suggesting that the interaction occurs at a metabolic level.
Albani
F
F
Laboratory of Neuropharmacology, University of Bologna, Italy.
Riva
R
R
Baruzzi
A
A
D000328:Adult; D002220:Carbamazepine / Q000493:pharmacokinetics / Q000494:pharmacology*; D017291:Clarithromycin / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy; D008297:Male
D002220:Carbamazepine; D017291:Clarithromycin