Cerebrospinal fluid interferon-gamma is increased in HTLV-I-associated myelopathy.
Serum and cerebrospinal fluid (CSF) levels of interferon-gamma (IFN-gamma) were assayed with an immunoenzymetric method in 16 patients with HTLV-I-associated myelopathy (HAM). IFN-gamma levels were elevated in serum of two patients and in CSF of nine. Although there was no significant association between the clinical features and the CSF IFN-gamma levels, the mean levels of CSF IgG and CSF anti-HTLV-I antibody titer were higher in patients with elevated CSF IFN-gamma levels than in those with normal CSF IFN-gamma levels.
Kuroda
Y
Y
Section of Neurology, Department of Internal Medicine, Saga Medical School, Japan.
Matsui
M
M
D000328:Adult; D000368:Aged; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000097:blood / Q000134:cerebrospinal fluid*
D015481:HTLV-I Antibodies; D007371:Interferon-gamma