title: Familial transitional cell carcinoma and the Lynch syndrome II.
abstract: A family is presented in which 4 male siblings developed transitional cell carcinoma (TCC). Four upper tract tumours occurred in 3 and in the fourth the tumour was intravesical. Two of these patients also had colorectal adenocarcinoma. There were 2 other relatives in the pedigree with large bowel cancer. It is suggested that this is an example of Lynch Syndrome II, a hereditary non-polyposis colorectal cancer with extracolonic cancer sites. The implications regarding the screening, surveillance and detection of possible carrier status in healthy relatives is discussed.
authors.affiliation: Department of Urology, Queen Elizabeth Hospital, Birmingham.
authors.forename: J E
authors.initials: JE
authors.lastname: Greenland
authors.forename: P M
authors.initials: PM
authors.lastname: Weston
authors.forename: D M
authors.initials: DM
authors.lastname: Wallace
mesh_terms: D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000209:etiology / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D014571:Urologic Neoplasms / Q000209:etiology / Q000235:genetics*