The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia.
Transmissible murine colonic hyperplasia is characterized by proliferation of anchored stem cells in the mucosa of the descending colon of laboratory mice and is caused by Citrobacter freundii biotype 4280. This bacterium produces attaching and effacing lesions in the descending colon prior to the onset of gross hyperplasia. By mutational analysis, the chromosomal eae gene of C. freundii biotype 4280 was shown to be necessary for colonic colonization. Conversely, bacteria cured of a 65-kb plasmid, which was identified in C. freundii biotype 4280, were not attenuated for colonic colonization or for the induction of colonic hyperplasia.
Schauer
D B
DB
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305-5402.
Falkow
S
S
D018829:Adhesins, Bacterial; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002352:Carrier Proteins; D016971:Citrobacter freundii / Q000235:genetics* / Q000472:pathogenicity; D003106:Colon / Q000382:microbiology / Q000473:pathology*; D004756:Enterobacteriaceae Infections / Q000382:microbiology* / Q000473:pathology; D029968:Escherichia coli Proteins; D017353:Gene Deletion; D005798:Genes, Bacterial; D006965:Hyperplasia; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation; D010957:Plasmids
D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; C073819:eaeA protein, E coli