The inherent DNase of pyocin AP41 causes breakdown of chromosomal DNA.
Pyocin AP41 degrades the chromosomal DNA in sensitive strains of Pseudomonas aeruginosa but has little effect on RNA, protein, and lipid syntheses. In vitro experiments showed that the carboxyl-terminal part of the large subunit of pyocin AP41 carries an inherent DNase that is responsible for its killing action.
Sano
Y
Y
Department of Molecular Biology, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
D000595:Amino Acid Sequence; D002876:Chromosomes, Bacterial / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D011709:Pyocins / Q000737:chemistry / Q000378:metabolism*; D014357:Trypsin
D004269:DNA, Bacterial; D010446:Peptide Fragments; D011709:Pyocins; D003851:Deoxyribonucleases; D014357:Trypsin