title: [Cytogenetic changes in peripheral blood lymphocytes in people with impaired thyroid status].
abstract: Increased counts of cells with chromosome aberrations were revealed in peripheral blood lymphocytes of subjects with thyroid dysfunction: 5.5 +/- 0.6% in hypothyrosis, 9.0 +/- 1.8% in hyperthyroidism, and 2.5 +/- 0.1% in controls (20 donors). The aberrations are mainly presented by paired and solitary fragments, rarely by chromatid translocations; in two patients with hyperthyroidism dicentrics were detected. Distribution of aberration types varied. In hypothyrosis chromosome aberrations were two times more incident than chromatid ones. In hyperthyroidism chromosome and chromatid aberrations were approximately equally incident. These results may be used to explain the causes of unfavorable outcomes of pregnancy in patients with thyroid diseases.
authors.forename: A A
authors.initials: AA
authors.lastname: Fedorova
authors.forename: E N
authors.initials: EN
authors.lastname: Antipenko
authors.forename: O I
authors.initials: OI
authors.lastname: Timchenko
mesh_terms: D002453:Cell Cycle / Q000235:genetics; D002869:Chromosome Aberrations / Q000502:physiology*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000235:genetics*; D007037:Hypothyroidism / Q000097:blood / Q000235:genetics*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000502:physiology*