title: (E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist.
authors.affiliation: Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
authors.forename: R A
authors.initials: RA
authors.lastname: Daines
authors.forename: P A
authors.initials: PA
authors.lastname: Chambers
authors.forename: I
authors.initials: I
authors.lastname: Pendrak
authors.forename: D R
authors.initials: DR
authors.lastname: Jakas
authors.forename: H M
authors.initials: HM
authors.lastname: Sarau
authors.forename: J J
authors.initials: JJ
authors.lastname: Foley
authors.forename: D B
authors.initials: DB
authors.lastname: Schmidt
authors.forename: D E
authors.initials: DE
authors.lastname: Griswold
authors.forename: L D
authors.initials: LD
authors.lastname: Martin
authors.forename: M N
authors.initials: MN
authors.lastname: Tzimas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007975:Leukotriene B4 / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D018102:Receptors, Leukotriene B4 / Q000037:antagonists & inhibitors*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D011725:Pyridines; D018102:Receptors, Leukotriene B4; C083427:(E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid; D007975:Leukotriene B4; D002118:Calcium