title: Antibodies to human serum albumin in familial dysautonomia.
abstract: Sera from familial dysautonomia patients are shown to contain high levels of antibodies to human serum albumin (HSA). The individual levels of anti-HSA antibodies correlate significantly with the levels of antibodies to bovine serum albumin and lactalbumin. These results and the findings that the anti-HSA level declines exponentially with age indicate that anti-HSA antibodies may be induced by aspiration of bovine milk antigens in infancy. The titer of the anti-HSA autoantibodies presently described (> 1:10,000) is much higher than those found in other diseases and may contribute to the pathological changes in familial dysautonomia.
authors.affiliation: Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Chapman
authors.forename: C
authors.initials: C
authors.lastname: Maayan
authors.forename: D M
authors.initials: DM
authors.lastname: Michaelson
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004402:Dysautonomia, Familial / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007223:Infant; D007768:Lactalbumin / Q000276:immunology; D008297:Male; D012709:Serum Albumin / Q000276:immunology*
chemical_list: D000906:Antibodies; D012709:Serum Albumin; D007768:Lactalbumin