title: Augmentation of human natural killer cells by splenopentin analogs.
abstract: Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-D-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), D-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.
authors.affiliation: Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
authors.forename: A
authors.initials: A
authors.lastname: Rastogi
authors.forename: V K
authors.initials: VK
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Biswas
authors.forename: W
authors.initials: W
authors.lastname: Haq
authors.forename: K B
authors.initials: KB
authors.lastname: Mathur
authors.forename: S S
authors.initials: SS
authors.lastname: Agarwal
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D002478:Cells, Cultured; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D013946:Thymopoietins / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D013946:Thymopoietins; C041898:splenopentin