[New cases of celiac disease detected by anti-endomysial antibody test in families of gluten-sensitive patients and among children examined for non-specific gastrointestinal complaints].
Among 228 relatives of 101 gluten-sensitive patients, 13 anti-endomysium antibody (EmA) positive persons (7 children and 6 adults) were identified. In 12/13 cases jejunal biopsy confirmed severe villous atrophy consistent with celiac disease. In the single EmA positive sibling without villous atrophy the histology is thought to be influenced by a steroid treatment because of pulmonary disease. By routine EmA-testing 12 unexpected EmA positive patients were found out of 756 children with complaints and laboratory results otherwise not justifying jejunal biopsy at the first evaluation. Their initial diagnoses were: proteinuria, colitis, Crohn's disease, rickets, recurrent vomiting, resolved postinfectious lactase deficiency, "previously excluded" celiac disease. Severe villous atrophy could be demonstrated in all EmA positive patients subsequently. In further 204 EmA negative children the biopsy showed no atrophy. EmA positivity may reveal clinically not apparent severe villous atrophy emphasizing the role of a new non invasive and highly specific serological screening method for celiac disease.
Korponay-Szabó
I
I
Fövárosi Onkormányzat Heim Pál Gyermekkórháza, Budapest.
Kovács
J
J
Lörincz
M
M
Körmendy
M
M
Sashegyi
J
J
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000276:immunology; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D005767:Gastrointestinal Diseases / Q000175:diagnosis; D005983:Glutens / Q000276:immunology; D006801:Humans; D007159:Immunologic Tests; D007223:Infant; D007583:Jejunum / Q000276:immunology / Q000473:pathology; D008297:Male; D008403:Mass Screening
D000906:Antibodies; D005983:Glutens