title: Pharmacokinetics of diphemanil methylsulphate in infants.
abstract: The pharmacokinetics of diphemanil methylsulphate was evaluated after oral administration of a single 3 mg.kg-1 dose to 5 infants being treated for symptomatic bradycardia. The mean pharmacokinetic parameters of oral diphemanil methylsulphate in infants were similar to those in adults. The mean half-life was 8.6 h. This would allow administration three times a day in infants instead of four to six times a day, as currently prescribed. The mean residence time decreases significantly with age (Spearman's r' = -1), and there is a trend for the half-life to decrease with age (r' = -0.9; NS), suggesting an influence of maturation on its elimination.
authors.affiliation: Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Vidal
authors.forename: G
authors.initials: G
authors.lastname: Chéron
authors.forename: E
authors.initials: E
authors.lastname: Rey
authors.forename: G
authors.initials: G
authors.lastname: Pons
authors.forename: P
authors.initials: P
authors.lastname: d'Athis
authors.forename: G
authors.initials: G
authors.lastname: Olive
mesh_terms: D000284:Administration, Oral; D001919:Bradycardia / Q000188:drug therapy / Q000378:metabolism; D004334:Drug Administration Schedule; D006207:Half-Life; D006801:Humans; D007223:Infant; D010276:Parasympatholytics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D010276:Parasympatholytics; D010880:Piperidines; C028209:diphemanil methylsulfate