[Relationship between biliary excretion of conjugated sulfobromophthalein and glutathione disulfide in rats].
Relationship between biliary excretion of sulfobromophthalein conjugated with glutathione (BSP-GSH) and glutathione disulfide (GSSG) was investigated in Sprague-Dawley rats. BSP-GSH solution was infused intravenously at three different rates. After administration of a glutathione-oxidizing agent, diamide, biliary excretion of GSSG increased temporarily and that of BSP-GSH decreased during the same period. A linear correlation was found between the increments in biliary excretion of GSSG and the decrements in that of BSP-GSH only when BSP-GSH was infused at a rate near its biliary transport maximum. The results may indicate competition in vivo between GSSG and BSP-GSH for a common transporter on canalicular membrane.
Iijima
M
M
Second Department of Internal Medicine, Dokkyo University School of Medicine.
Yoshida
H
H
Kuronuma
Y
Y
D000818:Animals; D001646:Bile / Q000378:metabolism*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism*; D019803:Glutathione Disulfide; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013448:Sulfobromophthalein / Q000378:metabolism*
D013448:Sulfobromophthalein; D005978:Glutathione; D019803:Glutathione Disulfide