Functional MRI of human brain activation at high spatial resolution.
Functional activation maps of the human visual cortex were obtained at a spatial resolution almost two orders of magnitude better than achievable by positron emission tomography and within measuring times of a few seconds. Transient alterations in the concentration of paramagnetic deoxyhemoglobin were conveniently detected at 2.0-T with use of RF-spoiled FLASH MRI sequences employing gradient echo times of 6 to 60 ms and voxel sizes of 2.5 to 39 microliters.
Frahm
J
J
Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany.
Merboldt
K D
KD
Hänicke
W
W
D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010775:Photic Stimulation