The effects of cocaine on dietary self-selection in female rats.
Cocaine was administered via an oral route to 18-h food deprived female rats for 14 consecutive days. Following administration of the drug or vehicle control each animal was presented with separate isocaloric rations of protein, fat, and carbohydrate in a dietary self-selection situation. Amounts consumed of each component were measured at 30 min, 60 min, 2 h, and 6 h following the drug treatment. The intake of all three macronutrients was suppressed by cocaine for 1 h. Between 2 and 6 h after administration, there was a compensatory increase in fat and carbohydrate, but not protein consumption. The results are discussed in terms of protein deficiency caused by cocaine in pregnant and/or lactating females being a causal factor in the deleterious effects on offspring.
Bane
A J
AJ
Department of Psychology, Colorado State University, Fort Collins 80523.
McCoy
J G
JG
Stump
B S
BS
Avery
D D
DD
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects*; D005260:Female; D005518:Food Preferences / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D003042:Cocaine