Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-beta.
The crystal structure of recombinant murine interferon-beta as elucidated by Senda et al. (Proc. Jap. Acad. 66B: 77-80 (1990); EMBO J. 11: 3193-3201 (1992)) appears to represent the basic structural framework of all Type I interferons including interferons-beta and all subtypes of interferons-alpha of various mammalian origin. Now the huge accumulated data on the structure-activity relationship of Type I interferons using various chemical and genetic techniques can be systematically evaluated in terms of the three-dimensional structure. Structural comparison with other cytokines, for which three-dimensional structures have been established, including interferon-gamma and considerations on the evolution of cytokines and cytokine receptors are also given.
Mitsui
Y
Y
Department of BioEngineering, Nagaoka University of Technology, Niigata, Japan.
Senda
T
T
Shimazu
T
T
Matsuda
S
S
Utsumi
J
J
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D003460:Crystallization; D018360:Crystallography, X-Ray; D016207:Cytokines / Q000737:chemistry; D006801:Humans; D016898:Interferon-alpha / Q000737:chemistry; D016899:Interferon-beta / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000737:chemistry; D017386:Sequence Homology, Amino Acid
D016207:Cytokines; D016898:Interferon-alpha; D011994:Recombinant Proteins; D016899:Interferon-beta