Poor outcome in radiation-induced constrictive pericarditis.
OBJECTIVE
To compare the outcome of patients with radiation-induced constrictive pericarditis versus patients with constriction due to another etiology.


METHODS
Twenty patients with constrictive pericarditis seen during 1975-1986 at a single medical center. Six had radiation-induced constrictive pericarditis (Group A). The etiology was idiopathic in ten subjects and secondary to carcinomatous encasement, chronic renal failure, purulent infection and tuberculosis in one patient each (Group B, N = 14). Mean age was 53.4 +/- 15.5 years.


RESULTS
Extensive pericardiectomy was performed in 3/6 Group A and 13/14 Group B patients. All Group A patients died, 4 weeks--11 years post-diagnosis (median = 10 months). Two Group A patients died suddenly, one died post-operatively of respiratory failure, another of pneumonia and two of recurrent carcinoma. Thirteen Group B patients are alive (median follow-up = 72 months). The only death in this group was due to metastatic cancer.


CONCLUSIONS
The poor outcome with radiation-induced constriction is probably multi-factorial. Poor surgical outcome is to be expected in patients with evidence of recurrent tumor, high-dose irradiation, pulmonary fibrosis or associated radiation-induced myocardial, valvular or coronary damage.
Karram
T
T
Department of Cardiology, Rambam Medical Center, Technion Medical School, Haifa, Israel.
Rinkevitch
D
D
Markiewicz
W
W
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010494:Pericarditis, Constrictive / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D016896:Treatment Outcome