title: 3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: A K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: W J
authors.initials: WJ
authors.lastname: Thompson
authors.forename: S P
authors.initials: SP
authors.lastname: McKee
authors.forename: T T
authors.initials: TT
authors.lastname: Duong
authors.forename: T A
authors.initials: TA
authors.lastname: Lyle
authors.forename: J C
authors.initials: JC
authors.lastname: Chen
authors.forename: P L
authors.initials: PL
authors.lastname: Darke
authors.forename: J A
authors.initials: JA
authors.lastname: Zugay
authors.forename: E A
authors.initials: EA
authors.lastname: Emini
authors.forename: W A
authors.initials: WA
authors.lastname: Schleif
mesh_terms: D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014520:Urethane / Q000031:analogs & derivatives*
chemical_list: D005663:Furans; D017320:HIV Protease Inhibitors; D008024:Ligands; D011714:Pyrans; D014520:Urethane