Gastrointestinal hemorrhage associated with gastric polyps in Menkes disease.
We describe two infants with Menkes disease who had serious gastrointestinal bleeding from solitary gastric polyps. Hemorrhage in one patient was acute and proved fatal. Histopathologic examinations showed submucosal vascular ectasia with mucosal hyperplasia, edema, and ulceration. Gastric polyps may represent an underappreciated clinical abnormality in Menkes disease.
Kaler
S G
SG
Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Westman
J A
JA
Bernes
S M
SM
Elsayed
A M
AM
Bowe
C M
CM
Freeman
K L
KL
Wu
C D
CD
Wallach
M T
MT
D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D007706:Menkes Kinky Hair Syndrome / Q000150:complications*; D011127:Polyps / Q000150:complications*; D011706:Pyloric Antrum; D013272:Stomach Diseases / Q000209:etiology*; D013274:Stomach Neoplasms / Q000150:complications*