title: Effect of gluten-free diet on bone mineral content in growing patients with celiac disease.
abstract: Osteoporosis is a complication of celiac disease in adulthood, but little is known about the influence of the disease on bone mineralization in children. In the present study we evaluated radial bone mineral content (BMC) in celiac children and adolescents at diagnosis and after they consumed a gluten-free diet (GFD). The BMC values of 33 celiac patients at diagnosis were significantly lower than those of 255 control subjects (P < 0.001). There was no difference between diabetic and non-diabetic celiac patients. In 14 patients the BMC increased significantly (P < 0.05, ANCOVA) after 1.28 y of GFD. In these patients the mean annual BMC increment was 0.07 g/cm, significantly greater (P < 0.05) than the increment of normal growing children (0.05 g.cm-1.y-1). Our data indicate that although osteoporosis complicates celiac disease during childhood and adolescence, GFD alone is able to remarkably improve bone mineralization.
authors.affiliation: Department of Pediatrics, Scientific Institute H San Raffaele, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mora
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: G
authors.initials: G
authors.lastname: Barera
authors.forename: A
authors.initials: A
authors.lastname: Bellini
authors.forename: D
authors.initials: D
authors.lastname: Pasolini
authors.forename: C
authors.initials: C
authors.lastname: Prinster
authors.forename: C
authors.initials: C
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Chiumello
mesh_terms: D015519:Bone Density; D001846:Bone Development; D002113:Calcification, Physiologic; D002446:Celiac Disease / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005983:Glutens / Q000008:administration & dosage*; D006801:Humans; D010024:Osteoporosis / Q000209:etiology; D011446:Prospective Studies; D012044:Regression Analysis
chemical_list: D005983:Glutens