Pargyline-induced increase in serotonin levels: correlation with inhibition of lordosis in rats.
The effect of intrahypothalamic infusion of the monoamine oxidase inhibitor pargyline on lordosis behavior and monamine levels in the preoptic area and hypothalamus was examined. Progesterone-facilitated lordosis was blocked by pargyline in half the treated rats. The inhibition of lordosis was correlated with increases in serotonin and dopamine levels in the ventromedial nucleus of the hypothalamus and serotonin levels in the arcuate nucleus-median eminence when compared to controls or pargyline-treated rats with high levels of lordosis responding. Changes in norepinephrine levels were not correlated with changes in behavior. The results provide further evidence for an inhibitory role of basomedial hypothalamic serotonin in the control of female sexual behavior.
Allen
D L
DL
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
Renner
K J
KJ
Luine
V N
VN
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000378:metabolism; D015306:Biogenic Monoamines / Q000378:metabolism; D005260:Female; D007267:Injections; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism; D010052:Ovariectomy; D010293:Pargyline / Q000008:administration & dosage / Q000494:pharmacology*; D011187:Posture; D011374:Progesterone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism
D015306:Biogenic Monoamines; D012701:Serotonin; D011374:Progesterone; D010293:Pargyline