title: Induction of phosphatidic acid by fibroblast growth factor in cultured baby hamster kidney fibroblasts.
abstract: Basic fibroblast growth factor (bFGF/FGF-2) is a strong mitogenic inducer of cultured baby hamster kidney (BHK) cells. When cultured BHK cells were stimulated with FGF-2, phosphatidic acid (PA) was induced within 2 min, peaked at 5 min and gradually decreased. Phospholipase D (PLD) was also mitogenic for cultured BHK cells and this effect was mediated via PA. The possibility that PA induction by FGF-2 is an essential signaling step for BHK cell proliferation is discussed.
authors.affiliation: Department of Anatomy and Cell Biology, University of Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Motoike
authors.forename: S
authors.initials: S
authors.lastname: Bieger
authors.forename: H
authors.initials: H
authors.lastname: Wiegandt
authors.forename: K
authors.initials: K
authors.lastname: Unsicker
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D004075:Diglycerides / Q000096:biosynthesis; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008934:Mitogens / Q000494:pharmacology; D010712:Phosphatidic Acids / Q000096:biosynthesis*; D010739:Phospholipase D / Q000502:physiology
chemical_list: D004075:Diglycerides; D008934:Mitogens; D010712:Phosphatidic Acids; D005346:Fibroblast Growth Factors; D010739:Phospholipase D