The effect of calcium channel blockade on the action of chronic ECT and imipramine on responses of alpha 1- and beta-adrenoceptors in the rat cerebral cortex.
Chronic co-administration of nifedipine and ECT or imipramine results in an increase in responsiveness of cerebral cortical alpha 1-adrenoceptors as measured by accumulation of inositol phosphate in cortical slices after noradrenaline stimulation; the responsiveness of beta-adrenoceptor, measured by accumulation of cyclic AMP, was depressed similarly by antidepressant treatment with and without nifedipine.
Nalepa
I
I
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Vetulani
J
J
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004565:Electroconvulsive Therapy; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D007295:Inositol Phosphates; D018340:Receptors, Adrenergic, alpha-1; D011943:Receptors, Adrenergic, beta; D009543:Nifedipine; D007099:Imipramine