title: Validation of a measure of physical illness burden at autopsy: the Cumulative Illness Rating Scale.
abstract: OBJECTIVE
  To further validate an objective measure of physical illness burden, the Cumulative Illness Rating Scale (CIRS).
  
  
  METHODS
  Survey with correlation of CIRS ratings made from physician interviews and review of medical records with post-mortem ratings made independently at tissue autopsy.
  
  
  METHODS
  Victims of completed suicide investigated by both psychological and tissue autopsy (n = 72).
  
  
  RESULTS
  CIRS ratings made by examination of tissue at autopsy were highly predictive of analogous ratings based on historical data, accounting for 75% of the variance in CIRS scores. Taking autopsy findings as the gold standard of objective health assessment, historical ratings tend to underestimate physical illness at high levels of tissue pathology and to overestimate burden at lower levels.
  
  
  CONCLUSIONS
  The CIRS score, when derived from all available sources of medical information, is a valid objective measure of physical illness burden and has broad applicability to research in geriatrics.
authors.affiliation: University of Rochester-NIMH Clinical Research Center for the Study of Psychopathology of the Elderly, NY.
authors.forename: Y
authors.initials: Y
authors.lastname: Conwell
authors.forename: N T
authors.initials: NT
authors.lastname: Forbes
authors.forename: C
authors.initials: C
authors.lastname: Cox
authors.forename: E D
authors.initials: ED
authors.lastname: Caine
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy / Q000592:standards*; D015897:Comorbidity; D005260:Female; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008499:Medical Records / Q000592:standards*; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D010820:Physicians; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013405:Suicide / Q000706:statistics & numerical data*