title: Differential health benefits of weight loss in upper-body and lower-body obese women.
abstract: Upper-body obesity (UB Ob) is more strongly associated with adverse health consequences; however, few obesity-treatment studies have examined outcome according to body-fat distribution. To examine whether diet and formal- or informal-exercise instruction causes differential changes in health and lipid profiles, ten LB Ob and nine UB Ob premenopausal women received dietary intervention (2.1 MJ-deficit/d for 16 wk) and were randomly assigned to either formal- or informal-exercise instruction. Weight loss was similar between groups (approximately 8 kg), and no change occurred in lean body mass or basal metabolic rate. Baseline cholesterol and triglycerides were greater (P < 0.01) in UB Ob than LB Ob women and decreased more (P < 0.01) in response to treatment in UB Ob women. Formal exercise instruction increased high-density-lipoprotein cholesterol (P < 0.05) especially in UB Ob women. Future studies on treatment of obesity should include consideration of regional fat distribution.
authors.affiliation: Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905.
authors.forename: J A
authors.initials: JA
authors.lastname: Kanaley
authors.forename: M L
authors.initials: ML
authors.lastname: Andresen-Reid
authors.forename: L
authors.initials: L
authors.lastname: Oenning
authors.forename: B A
authors.initials: BA
authors.lastname: Kottke
authors.forename: M D
authors.initials: MD
authors.lastname: Jensen
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001481:Basal Metabolism; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000178:diet therapy / Q000628:therapy*; D010101:Oxygen Consumption; D011897:Random Allocation; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D001053:Apolipoproteins; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol