The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21.
The human interleukin-6 receptor alpha chain (IL6R alpha) gene was regionally mapped to chromosome 1 band q21 by fluorescence in situ hybridization. As hybridization probes, partially overlapping lambda clones encompassing 28 kb of the genomic region of the gene were used. These clones were isolated using a polymerase chain reaction (PCR)-generated fragment of the 3' non-coding region of the gene. This localization confirms and extends the provisional assignment of the IL6R alpha gene to chromosome 1, for which a panel of somatic cell hybrids was used.
Kluck
P M
PM
Department of Hematology, University Medical Center, Leiden, The Netherlands.
Wiegant
J
J
Jansen
R P
RP
Bolk
M W
MW
Raap
A K
AK
Willemze
R
R
Landegent
J E
JE
D002878:Chromosomes, Human, Pair 1; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015850:Interleukin-6; D016133:Polymerase Chain Reaction; D011971:Receptors, Immunologic / Q000235:genetics*; D019947:Receptors, Interleukin-6; D015183:Restriction Mapping
D015850:Interleukin-6; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6