title: Subcutaneous injection of an analog of neuropeptide FF precipitates morphine abstinence syndrome.
abstract: Neuropeptide FF (NPFF) has been shown to exert various antiopiate actions, including precipitation of opiate abstinence syndrome by third ventricle injection in morphine dependent rats. In the present study, dansyl-Pro-Gln-Arg-Phe-amide, a lipophilic analog of NPFF, was injected into morphine dependent rats and appropriate sham controls at a dose of 9 mg/kg s.c. Comparison groups were injected with ethanol/water vehicle alone. The NPFF analog precipitated a vigorous opiate abstinence syndrome in morphine dependent rats, but not in sham controls.
authors.affiliation: Univ. of Houston, Clear Lake, TX 77058.
authors.forename: D H
authors.initials: DH
authors.lastname: Malin
authors.forename: J R
authors.initials: JR
authors.lastname: Lake
authors.forename: K R
authors.initials: KR
authors.lastname: Arcangeli
authors.forename: K D
authors.initials: KD
authors.lastname: Deshotel
authors.forename: D D
authors.initials: DD
authors.lastname: Hausam
authors.forename: W E
authors.initials: WE
authors.lastname: Witherspoon
authors.forename: V A
authors.initials: VA
authors.lastname: Carter
authors.forename: H Y
authors.initials: HY
authors.lastname: Yang
authors.forename: B
authors.initials: B
authors.lastname: Pal
authors.forename: K
authors.initials: K
authors.lastname: Burgess
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D007279:Injections, Subcutaneous; D008297:Male; D008969:Molecular Sequence Data; D009020:Morphine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D009021:Morphine Dependence; D009479:Neuropeptides / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome
chemical_list: D009479:Neuropeptides; D009842:Oligopeptides; C083645:dansyl-prolyl-glutaminyl-arginyl-phenylalaninamide; D009020:Morphine