Involvement of brain serotonergic function in lidocaine-induced convulsions in mice.
Influences of drug-induced manipulations of central serotonergic function on lidocaine- and pentylenetetrazol (PTZ)-induced convulsions were examined in mice. Agents that suppressed serotonergic transmission increased, whereas drugs that facilitated serotonin (5-HT) function decreased the incidence of lidocaine-induced convulsions. These treatments had similar influences on the incidence of PTZ-induced convulsions. Lidocaine (10(-5)-10(-3) M) reduced the stimulation evoked [3H]5-HT release from cortical slices, followed with an increased spontaneous [3H] overflow at higher concentrations. These results may suggest that brain 5-HT neurons are causally involved as inhibitory neurons in lidocaine-induced convulsions as in the case of PTZ-induced convulsions.
Endo
K
K
Department of Oral and Maxillofacial Surgery, Hiroshima University School of Dentistry, Japan.
Morita
K
K
Uchiyama
Y
Y
Takada
K
K
Tsujimoto
A
A
Dohi
T
T
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004558:Electric Stimulation; D008012:Lidocaine / Q000633:toxicity*; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010433:Pentylenetetrazole / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D008012:Lidocaine; D006916:5-Hydroxytryptophan; D010433:Pentylenetetrazole