title: [Efficacy and safety of azithromycin in the treatment of female genital Chlamydia trachomatis infections].
abstract: Genital tract infections by Chlamydia trachomatis associated to sterility and infertility problems as well as perinatal complications have become increasingly frequent. Azithromycin is a new macrolide with a lower activity spectrum than erythromycin and a longer half life as well as less secondary effects. The objective of the study was to evaluate the safety and efficiency of Azithromycin on genital tract infection by C. trachomatis. MATERIAL AND METHODOLOGY. A total of 30 nonpregnant women between the ages of 19 and 35 were studied; 70% had only one sexual partner. In order to insure the presence of C. trachomatis as unique pathogen, cervicovaginal sampling, clinical evaluation and gynecologic exploration were undertaken. One dose of 1 g orally of Azithromycin was administered evaluating microbiologic and clinical remission at days 7-10, 12-16 and 33-37 after treatment. RESULTS. Two patients abandoned the study; global criteria of the evaluation were good to excellent in 17 cases; moderate to sufficient in six and poor in five. None of the cases reported secondary reactions. Results showed that Azithromycin treatment of cervicitis by C. trachomatis is useful with the advantage of unique dose administration.
authors.affiliation: Departamento de Infectología e Inmunología, Instituto Nacional de Perinatología, México, D.F.
authors.forename: L E
authors.initials: LE
authors.lastname: Narcio Reyes
authors.forename: G
authors.initials: G
authors.lastname: Casanova Roman
authors.forename: J L
authors.initials: JL
authors.lastname: Arredondo Garcia
mesh_terms: D000293:Adolescent; D000328:Adult; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000187:drug effects / Q000302:isolation & purification*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D002575:Uterine Cervicitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D017963:Azithromycin