title: Investigation of an outbreak of Salmonella typhi in a public school in Madrid.
abstract: A typhoid fever outbreak affecting 54 school students occurred in a Public School of Móstoles, Madrid. The date of onset was 11 June 1991 and the last detected case was 8 July 1991. Salmonella typhi was cultured from blood and/or stool samples corresponding to 54 patients and one food-handler. There were no secondary cases detected. Epidemiological investigation suggested a salad or a custard as the common source. Patients and the food-handler were treated with ampicillin/amoxicillin for up to three weeks. There were seven relapses that were also treated with the same antibiotics with success. None were found to be excreting the organisms when tested after four months. All the Salmonella typhi isolated strains were phagetype 34, biotype Xylose +, Tetrationate Reductase + and harboured a similar 22 Mdal plasmid, they were also susceptible to the antibiotics tested.
authors.affiliation: Sección de Enterobacterias, Centro Nacional de Microbiología Virologia e Inmunología Sanitarias, Madrid, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Usera
authors.forename: A
authors.initials: A
authors.lastname: Aladueña
authors.forename: A
authors.initials: A
authors.lastname: Echeita
authors.forename: E
authors.initials: E
authors.lastname: Amor
authors.forename: J L
authors.initials: JL
authors.lastname: Gomez-Garcés
authors.forename: C
authors.initials: C
authors.lastname: Ibañez
authors.forename: I
authors.initials: I
authors.lastname: Mendez
authors.forename: J C
authors.initials: JC
authors.lastname: Sanz
authors.forename: M
authors.initials: M
authors.lastname: Lopez-Brea
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000627:therapeutic use; D000667:Ampicillin / Q000627:therapeutic use; D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D002648:Child; D004196:Disease Outbreaks; D005243:Feces / Q000382:microbiology; D005260:Female; D005511:Food Handling / Q000706:statistics & numerical data; D005516:Food Microbiology; D006801:Humans; D015994:Incidence; D008297:Male; D008826:Microbial Sensitivity Tests; D010088:Oxidoreductases; D010957:Plasmids; D011159:Population Surveillance; D012008:Recurrence; D012485:Salmonella typhi / Q000145:classification / Q000302:isolation & purification; D012574:Schools; D013030:Spain / Q000453:epidemiology; D013334:Students / Q000706:statistics & numerical data; D014435:Typhoid Fever / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D014505:Urban Population; D014994:Xylose
chemical_list: D000667:Ampicillin; D000658:Amoxicillin; D014994:Xylose; D010088:Oxidoreductases; C022727:tetrathionate reductase