Molecular biology of excitatory amino acid receptors: subtypes and subunits.
Glutamate receptors coupled to ion channels have been named according to their selective agonist: N-methyl-D-Aspartate (NMDA), kainate, quisqualate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA). The pharmacology of the NMDA receptor is clearly different from that of the kainate, quisqualate and AMPA receptors, thus differentiating two types: NMDA and non-NMDA receptors. Molecular cloning and expression of non-NMDA receptor subunits have now established that the different neuronal responses to kainate, quisqualate and AMPA are mediated by at least two subtypes of ligand-gated channels: one responding to the three ligands, the other responding to kainate and quisqualate but not to AMPA.
Bochet
P
P
Institut Alfred Fessard, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Rossier
J
J
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D010802:Phylogeny; D017433:Protein Structure, Secondary; D012333:RNA, Messenger / Q000235:genetics; D017459:Receptors, Amino Acid / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D017470:Receptors, Glutamate / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000502:physiology; D017386:Sequence Homology, Amino Acid
D046911:Macromolecular Substances; D012333:RNA, Messenger; D017459:Receptors, Amino Acid; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate