title: Early MRI findings in Creutzfeldt-Jakob disease.
abstract: We describe the MRI changes preceding the onset of myoclonus in two patients whose post-mortem examination confirmed the diagnosis of Creutzfeldt-Jakob disease (CJD). MRI showed changes in the striatum early in the course of CJD (2-6 months after the onset of apathy, interpreted as depression, and 1-2 months before the onset of further clinical symptoms). Only in one patient did electroencephalography record the typical triphasic sharp-waves, 1 month after MRI.
authors.affiliation: Istituto di Neurologia, Università G. D'Annunzio, Chieti, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Onofrj
authors.forename: T
authors.initials: T
authors.lastname: Fulgente
authors.forename: D
authors.initials: D
authors.lastname: Gambi
authors.forename: G
authors.initials: G
authors.lastname: Macchi
mesh_terms: D001921:Brain / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009207:Myoclonus / Q000473:pathology; D013997:Time Factors