title: Amyloid destructive spondyloarthropathy causing cord compression: related to chronic renal failure and dialysis.
abstract: Destructive spondyloarthropathy is a recently recognized disease that has not been reported in the neurosurgical literature. It is associated with spinal amyloid deposition in long-term renal failure and dialysis, and it occurs increasingly as the number of dialysis patients and their survival times increase. Clinically, there is a multisegmental and often rapidly progressive radiculomyelopathy that may require emergency stabilization. The radiological features are disc space narrowing with erosion of vertebral end plates and subarticular cysts. The pathological features include deposition of amyloid, which stains with Congo Red and antibodies to beta-2-microglobulin. We present two cases with clinical, radiological, and pathological features and a review of the literature.
authors.affiliation: Department of Pathology, Toronto Hospital, Ontario, Canada.
authors.forename: G S
authors.initials: GS
authors.lastname: Davidson
authors.forename: W J
authors.initials: WJ
authors.lastname: Montanera
authors.forename: J F
authors.initials: JF
authors.lastname: Fleming
authors.forename: F
authors.initials: F
authors.lastname: Gentili
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000601:surgery*; D002574:Cervical Vertebrae / Q000473:pathology / Q000601:surgery*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008875:Middle Aged; D009460:Neurologic Examination; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000601:surgery*; D013122:Spinal Diseases / Q000175:diagnosis / Q000601:surgery*; D013123:Spinal Fusion; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D001613:beta 2-Microglobulin