[Synthesis of 11-aryl-7,8,9,10-tetrahydro-1,2,3-triazino-(4',5':4,5)-thienol- -(2,3-b)-quinolines with antianaphylactic action].
Title compounds of structure B with an oxo function in position 4 of the triazine ring were synthesized by reaction of the aminocarboxamides A with sodium nitrite in acetic acid. Aminocarbonitriles of structure H yielded with sodium nitrite in acetic acid and hydrochloric acid the 4-chloro derivatives I. These compounds gave with N-nucleophiles, methoxide or thiourea the substances J. Tetracyclic compounds with a hydroxyethyl or a piperidinoethyl residue in position 3 in the triazine ring (E, G) were also prepared. Some of the investigated compounds showed an antianaphylactic activity.
Wagner
G
G
Fachbereich Biowissenschaften der Universität Leipzig.
Vieweg
H
H
Leistner
S
S
D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D011804:Quinolines; D014227:Triazines