title: Quantitative structure-activity relationship studies on benzodiazepine receptor binding: investigation of interaction model.
abstract: With a view to providing perfection to the benzodiazepine receptor model proposed earlier [S P Gupta, R N Saha & V Mulchandani (1992) J. Mol. Recog, 5, 75-80] a few more QSAR studies on a series of 9-benzylpurines and tetracyclic 1,4-benzodiazepine derivatives have been made. The models showing the interaction of these compounds with the receptor are proposed. It is found that the receptor model, unlike the one proposed earlier, requires the presence of a polar site along with all the other essential sites.
authors.affiliation: Departments of Chemistry, Birla Institute of Technology and Science, Pilani.
authors.forename: S P
authors.initials: SP
authors.lastname: Gupta
authors.forename: V
authors.initials: V
authors.lastname: Mulchandani
mesh_terms: D001569:Benzodiazepines / Q000378:metabolism* / Q000494:pharmacology*; D001665:Binding Sites; D001667:Binding, Competitive; D003975:Diazepam / Q000378:metabolism; D007700:Kinetics; D015394:Molecular Structure; D011487:Protein Conformation; D011963:Receptors, GABA-A / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D011963:Receptors, GABA-A; D001569:Benzodiazepines; D003975:Diazepam