Protective effect of the calcium channel blocker diltiazem on hepatic function following warm ischemia.
The purpose of this study was to investigate the protective effect of a calcium channel blocker diltiazem (DTZ) on hepatic ischemic injury using a canine model. Hepatic ischemia was induced by temporary clamping of hepatic afferent blood vessels for 60 min with establishment of a portojugular bypass. The administration of DTZ at a dose of 70 micrograms/kg bolus i.v. injection before hepatic ischemia and thereafter via the portal vein at a dose of 10 micrograms/kg/min well restored the hepatic blood flow (HBF, 92 +/- 5%; P < 0.01) and arterial ketone body ratio (AKBR, 1.15 +/- 0.16; P < 0.01) 1 hr after interruption compared with untreated controls (HBF, 61 +/- 7%; AKBR, 0.53 +/- 0.09). In addition, the increase of plasma lactate level and the decrease of mean arterial pressure were significantly suppressed after ischemia (P < 0.05). We concluded that DTZ has a protective effect on ischemia-induced hepatic damage and might be useful in the prevention of primary graft failure caused by warm ischemia in liver transplantation.
Hisanaga
M
M
First Department of Surgery, Nara Medical University, Japan.
Nakajima
Y
Y
Wada
T
T
Kanehiro
H
H
Fukuoka
T
T
Horikawa
M
M
Yoshimura
A
A
Kido
K
K
Taki
J
J
Aomatsu
Y
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004110:Diltiazem / Q000494:pharmacology* / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D005263:Femoral Artery; D006358:Hot Temperature; D007511:Ischemia / Q000150:complications / Q000503:physiopathology*; D007657:Ketone Bodies / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology*; D008107:Liver Diseases / Q000209:etiology / Q000517:prevention & control; D008297:Male
D007657:Ketone Bodies; D007773:Lactates; D019344:Lactic Acid; D004110:Diltiazem