Changes of certain biochemical placental components during Salbupart tocolysis.
The studies material comprised 10 placentae from pregnancies at risk for premature labour with delayed intrauterine growth of the fetus treated with Salbupart from the 32nd week of pregnancy. In placental homogenates the biochemical components were determined for fragmentary assessment of carbohydrate and lipid metabolism and production on high-energy compounds. Salbupart was found to increase the oxidation processes in the placenta. This increases the production of biologically useful chemical energy which is expressed as increased energy charge (so called Atkinson's index or adenylate energy charge). Increased energy yield of the placenta results in improved materno-fetal transport and contributes to greater weight gain of the hypotrophic fetus.
Laudański
T
T
Department of Perinatology, Medical Academy, Lódź, Poland.
Armatys
A
A
Korczyński
J
J
Sobkiewicz
S
S
Tyliński
W
W
D000420:Albuterol / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006801:Humans; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D015145:Tocolysis
C063798:Salbupart; D000420:Albuterol