Relationships between blood pressure and lipids in childhood.
This review has discussed the potential interrelationships of elevated blood pressure and lipid abnormalities. Most of the data for this review have been collected in adults, but physiologic and genetic effects may have expression in childhood. Clustering of cardiac risk factors may be mediated by increased levels of insulin. These increased levels of insulin may be genetically determined or may be related to obesity. Recognition of the multiple risk factor phenotype is important, because individuals with multiple risk may have a much higher risk of future coronary events than do individuals with single risk factors. Medical therapy of individuals with multiple risk should be more aggressive than for individuals with single risk factors. Physicians should be cautious about therapy in the pediatric setting because of possible interaction between therapeutic agents and risk factors, however.
Gidding
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Division of Cardiology, Children's Memorial Hospital, Chicago, Illinois.
D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications*; D006973:Hypertension / Q000097:blood* / Q000150:complications; D008019:Life Style; D008055:Lipids / Q000097:blood*; D012307:Risk Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids