title: Ethanol inhibits tetraethylammonium chloride-induced synaptic plasticity in area CA1 of rat hippocampus.
abstract: Dendritic recordings of the rat hippocampal formation were used to assess the ability of ethanol to inhibit the induction of synaptic plasticity due to bath application of the K+ channel blocker, tetraethylammonium chloride (TEA). Brief application of TEA resulted in the enhancement of the population excitatory postsynaptic potential (EPSP) slope by an average of 26 +/- 3% over the pre-TEA baseline. However, coapplication of TEA and ethanol (100 mM) resulted in enhancement of only 10 +/- 2% of the EPSP slope. These data suggest that LTP (long-term potentiation) due to the activation of voltage-gated Ca2+ channels is also inhibited by ethanol.
authors.affiliation: Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198-6260.
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: R A
authors.initials: RA
authors.lastname: Morrisett
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D000431:Ethanol / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D015221:Potassium Channels; D013757:Tetraethylammonium Compounds; D000431:Ethanol; D019789:Tetraethylammonium