Erythrophagocytosis by cultured skin fibroblasts from patients with hereditary metabolic disorders.
Phagocytosis of native allogenic red blood cells was observed in cultures of skin fibroblasts obtained from patients with neuronal ceroid-lipofuscinosis, Niemann-Pick disease type C and morbus Fabry. Occasional phagocytizing cells were observed in 9 other syndromes. Cells from three normal donors did not phagocytize.
Elleder
M
M
1st Department of Pathology, 1st Prague Medical Faculty, Charles University, Czechoslovakia.
Holecková
E
E
Mandys
V
V
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology*; D005347:Fibroblasts; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008661:Metabolism, Inborn Errors / Q000276:immunology*; D009472:Neuronal Ceroid-Lipofuscinoses / Q000276:immunology; D009542:Niemann-Pick Diseases / Q000276:immunology; D010587:Phagocytosis