title: Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.
authors.affiliation: Monsanto Corporate Research, Medicinal Chemistry Department, St. Louis, Missouri 63167.
authors.forename: D P
authors.initials: DP
authors.lastname: Getman
authors.forename: G A
authors.initials: GA
authors.lastname: DeCrescenzo
authors.forename: R M
authors.initials: RM
authors.lastname: Heintz
authors.forename: K L
authors.initials: KL
authors.lastname: Reed
authors.forename: J J
authors.initials: JJ
authors.lastname: Talley
authors.forename: M L
authors.initials: ML
authors.lastname: Bryant
authors.forename: M
authors.initials: M
authors.lastname: Clare
authors.forename: K A
authors.initials: KA
authors.lastname: Houseman
authors.forename: J J
authors.initials: JJ
authors.lastname: Marr
authors.forename: R A
authors.initials: RA
authors.lastname: Mueller
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006918:Hydroxyurea / Q000031:analogs & derivatives*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D014508:Urea; C079293:SC 52151; D006918:Hydroxyurea