Bistramide A-induced irreversible arrest of cell proliferation in a non-small-cell bronchopulmonary carcinoma is similar to induction of terminal maturation.
Bistramide A, a new toxin isolated from a New Caledonian Urochordata, shows an antiproliferative effect on a non-small-cell lung carcinoma line in vitro and G1-blockade. In this work, the growth arrest induced by bistramide A was shown to be irreversible as assessed by growth kinetics of pretreated cells. Furthermore, the drug caused an underexpression of the nuclear antigen Ki67. These events are similar to a G1-differentiation cell cycle step blockage and a terminal maturation induction.
Riou
D
D
Groupe de recherche 'Substances marines à Activité Biologique' (SMAB), Faculté de Pharmacie, Nantes, France.
Roussakis
C
C
Robillard
N
N
Biard
J F
JF
Verbist
J F
JF
D000081:Acetamides; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002453:Cell Cycle / Q000276:immunology; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D004988:Ethers, Cyclic / Q000494:pharmacology*; D006801:Humans; D019394:Ki-67 Antigen; D008175:Lung Neoplasms / Q000188:drug therapy*; D009363:Neoplasm Proteins / Q000032:analysis; D009687:Nuclear Proteins / Q000032:analysis; D011714:Pyrans; D013141:Spiro Compounds; D014407:Tumor Cells, Cultured
D000081:Acetamides; D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011714:Pyrans; D013141:Spiro Compounds; C059975:bistratene A