Antecedent clinical features associated with dementia in Parkinson's disease.
In a prospective cohort study, we examined clinical features in 250 nondemented patients with idiopathic Parkinson's disease (PD) and then evaluated their association with incident dementia during 5 years of follow-up. Seventy-four of the patients became demented. Odds ratios for incident dementia with PD were increased for the following: being older than 70 years of age (2.7; 1.4 to 5.5), having a PD rating scale score greater than 25 (3.0; 1.5 to 6.2), being depressed (2.7; 1.5 to 6.6), being confused or psychotic on levodopa (3.3; 1.3 to 8.7), or having facial masking as a presenting sign (6.1; 1.4 to 26.9).
Stern
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Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY.
Marder
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Tang
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Mayeux
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R
D000368:Aged; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology; D003863:Depression / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D015995:Prevalence; D011605:Psychoses, Substance-Induced / Q000453:epidemiology; D012307:Risk Factors
D007980:Levodopa