Effects of water immersion stress on convulsions induced by pentylenetetrazol.
Increasing durations of water immersion stress were associated with increased serum corticosterone levels, decreased severity of pentylenetetrazol-induced convulsions, and increased latencies to convulse in rats. The results were interpreted in terms of the effects of stress and pentylenetetrazol's actions on GABAergic mechanisms.
Abel
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C. S. Mott Center for Human Growth and Development, Department of Obstetrics/Gynecology, Wayne State University, Detroit, MI 48201.
Berman
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D000818:Animals; D003345:Corticosterone / Q000097:blood; D007101:Immersion; D008297:Male; D010433:Pentylenetetrazole; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*
D003345:Corticosterone; D010433:Pentylenetetrazole