title: Is there a relationship between subclinical myocardial abnormalities, conduction defects and Ro/La antibodies in adults with systemic lupus erythematosus?
abstract: Thirty-three adult patients with systemic lupus erythematosus (SLE) were studied to determine whether there was an association between subclinical abnormalities of left ventricular function, conduction defects, and the presence of antibodies to Ro and/or La. Twelve patients had one or both of these antibodies. Conduction defects were present in 2, neither being currently positive for Ro or La antibody. There was no difference in abnormalities of left ventricular function between those with or without antibody. Valvular abnormalities were present in 11, 6 of whom had focal or diffuse thickening of one or more valves. Adults with SLE and anti-Ro and/or La antibody do not appear to be at particular risk of conduction defects. Subclinical left ventricular functional abnormalities were not associated with the presence of these antibodies.
authors.affiliation: ARC Epidemiology Research Unit, Manchester University, U.K.
authors.forename: T W
authors.initials: TW
authors.lastname: O'Neill
authors.forename: A
authors.initials: A
authors.lastname: Mahmoud
authors.forename: A
authors.initials: A
authors.lastname: Tooke
authors.forename: R D
authors.initials: RD
authors.lastname: Thomas
authors.forename: P J
authors.initials: PJ
authors.lastname: Maddison
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006331:Heart Diseases / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies