title: Indium-111-labeled polyclonal human immunoglobulin: identifying focal infection in patients positive for human immunodeficiency virus.
abstract: Pooled human immunoglobulin labeled with indium-111 (111In-HIgG) was used to identify the presence and extent of infection in patients positive for human immunodeficiency virus (HIV), presenting with either symptoms and/or signs of acute chest infection or with pyrexia without localizing signs or symptoms. Fifty-five studies were performed in 51 patients with suspected chest infection or pyrexia without localizing signs. Of these, 111In-HIgG identified intrapulmonary accumulation in 17 patients with Pneumocystis carinii pneumonia, eight with bacterial pneumonia, five with cytomegalovirus pneumonia, three with pulmonary Mycobacterium avium intracellulare infection and one with a fungal pneumonia. There was no intrapulmonary accumulation of 111In-HIgG in five patients with bronchopulmonary Kaposi's sarcoma and in three patients with intrathoracic lymphoma. Quantification of lung/heart activity was significantly increased (p < 0.05) in patients with active chest infection compared with those with intrapulmonary tumor or no active lung pathology. Indium-111-HIgG scintigraphy also localized at 14 sites of extrapulmonary infection, including six patients with colitis. There were no false-negative studies but false-positive uptake was seen in four studies. These results confirm that 111In-HIgG correctly identifies the presence and extent of infection in patients positive for HIV antibody.
authors.affiliation: Institute of Nuclear Medicine, University College London School of Medicine, England.
authors.forename: J R
authors.initials: JR
authors.lastname: Buscombe
authors.forename: W J
authors.initials: WJ
authors.lastname: Oyen
authors.forename: A
authors.initials: A
authors.lastname: Grant
authors.forename: R A
authors.initials: RA
authors.lastname: Claessens
authors.forename: J
authors.initials: J
authors.lastname: van der Meer
authors.forename: F H
authors.initials: FH
authors.lastname: Corstens
authors.forename: P J
authors.initials: PJ
authors.lastname: Ell
authors.forename: R F
authors.initials: RF
authors.lastname: Miller
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D005260:Female; D005490:Focal Infection / Q000150:complications / Q000000981:diagnostic imaging*; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000000981:diagnostic imaging; D011020:Pneumonia, Pneumocystis / Q000000981:diagnostic imaging; D011446:Prospective Studies; D016719:Radioimmunodetection; D012680:Sensitivity and Specificity
chemical_list: D007074:Immunoglobulin G; D007205:Indium Radioisotopes