title: Chromosome 12 alterations and c-Ki-ras mutations in colorectal tumors.
abstract: c-Ki-ras mutations and gains of chromosome 12, where this gene is mapped, were both studied in a series of 47 colorectal cancers. Mutations at codon 12 and 13 were detected in 17 (36%) and gains of chromosome 12 in 7 (15%) cases. In this sample, gains of chromosome 12 occur in tumors either with or without c-Ki-ras mutations, suggesting that gains of chromosome 12 are independent from the mutation of c-Ki-ras.
authors.affiliation: CNRS URA 620, Institut Curie, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Muleris
authors.forename: P
authors.initials: P
authors.lastname: Laurent-Puig
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon
authors.forename: G
authors.initials: G
authors.lastname: Thomas
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
mesh_terms: D002881:Chromosomes, Human, Pair 12; D015179:Colorectal Neoplasms / Q000235:genetics*; D011905:Genes, ras; D006801:Humans; D009154:Mutation