title: Synthesis and biological properties of some 3-[(N-substituted-amino)pyridinium-4-thiomethyl]-7-[2-(2-amino-thiazol- 4-yl)-2-(Z)-(methoxyimino)acetamido]ceph-3-em-4-carboxylates.
abstract: The synthesis and antibacterial activity of a series of beta-lactamase stable, broad spectrum 7-[2-(2-amino-thiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-cephalo sporins, characterised by a C-3-[N-(substituted-amino)pyridinium-4-thiomethyl] group, is described. Gram-positive and Gram-negative bacteria including extended spectrum beta-lactamase-producing strains were most susceptible to the N-amino- and N-methylamino derivatives (3a) and (3b); with the exception of Pseudomonas aeruginosa, (3b) was more active in vitro and in vivo than cefpirome or ceftazidime.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, U.K.
authors.forename: C L
authors.initials: CL
authors.lastname: Branch
authors.forename: R G
authors.initials: RG
authors.lastname: Adams
authors.forename: E G
authors.initials: EG
authors.lastname: Brain
authors.forename: A W
authors.initials: AW
authors.lastname: Guest
authors.forename: F P
authors.initials: FP
authors.lastname: Harrington
authors.forename: S J
authors.initials: SJ
authors.lastname: Knott
authors.forename: M J
authors.initials: MJ
authors.lastname: Pearson
authors.forename: I I
authors.initials: II
authors.lastname: Zomaya
mesh_terms: D000818:Animals; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins