title: Influenza--a model of an emerging virus disease.
abstract: Influenza A viruses continue to emerge from the aquatic avian reservoir and cause pandemics. Phylogenetic analysis of the nucleotide sequence of all eight influenza A virus RNA segments indicate that all of the influenza viruses in mammalian hosts originate from the avian gene pool. In contrast to the rapid progressive changes in both the nucleotide and amino acid sequences of mammalian virus gene lineages, avian virus genes show far less variation and, in most cases, appear to be in evolutionary stasis. There are periodic exchanges of influenza virus genes or whole viruses between species giving rise to pandemics of diseases in humans, lower animals and birds. The periodic emergence of influenza viruses in mammalian species has been illustrated by the appearance of a new influenza virus in horses in northern China in 1989. Phylogenetic analysis of classical H1N1, avian-like H1N1 and human H3N2 viruses circulating in Italian pigs reveals that genetic reassortment is taking place between avian- and human-like viruses in the European pig population. These studies provide evidence supporting the possibility that pigs serve as a mixing vessel for reassortment between influenza viruses in mammalian and avian hosts and raise the question of whether the next pandemic of influenza will emerge in Europe!
authors.affiliation: Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tenn. 38101.
authors.forename: R G
authors.initials: RG
authors.lastname: Webster
authors.forename: S M
authors.initials: SM
authors.lastname: Wright
authors.forename: M R
authors.initials: MR
authors.lastname: Castrucci
authors.forename: W J
authors.initials: WJ
authors.lastname: Bean
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaoka
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004197:Disease Reservoirs; D006801:Humans; D009980:Influenza A virus / Q000145:classification / Q000235:genetics*; D007251:Influenza, Human / Q000382:microbiology* / Q000635:transmission