title: A clinico-pathological study of adult histiocytosis X involving the brain.
abstract: Adult histiocytosis X involving the CNS caused progressive spastic paraparesis. The diagnosis was made by immunoreactive anti-S100 protein antibody staining and from the presence of Birbeck granules in biopsy specimens of skin lesions. Neuropathological examination showed massive proliferation and infiltration of S-100 containing histiocyte-like cells and reactive astrocytes throughout the CNS.
authors.affiliation: Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Mitomi
authors.forename: H
authors.initials: H
authors.lastname: Kowa
authors.forename: T
authors.initials: T
authors.lastname: Motoori
authors.forename: S
authors.initials: S
authors.lastname: Yagisita
mesh_terms: D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000209:etiology; D010243:Paralysis / Q000209:etiology; D012867:Skin / Q000473:pathology