Formation of mucosal polyps in the nasal and maxillary sinus cavities by infection.
Unilateral maxillary sinusitis was experimentally induced in New Zealand White rabbits with Streptococcus pneumoniae serotype 3, Bacteroides fragilis NCTC 9343, and Staphylococcus aureus V8. In another group of rabbits, sinusitis was induced by blocking of the sinus ostium only. Bacteriologic and light microscopic analysis was performed after 5 days to 1 month. Granulation-like polyps developed after deep mucosal inflammatory trauma initiating fibroblast proliferation, angiogenesis, and epithelial migration to cover the polyp. In regions of a more superficial trauma-characterized by epithelial desquamation and fibroblast growth-proliferation and differentiation of basal cells resulted in the formation of microcavities dissecting off edematous polyps. Polyps could be found in all sinusitis groups, irrespective of inducing agent. The cellular events of polyp formation appear to be the result of a continuous inflammatory reaction and are not directly related to the presence of a certain microorganism. Instead, the potential of any microorganism to induce a deep mucosal trauma or epithelial desquamation seems essential for its ability to initiate polyp formation.
Norlander
T
T
Department of Otorhinolaryngology, Karolinska Institute, Huddinge Hospital, Sweden.
Fukami
M
M
Westrin
K M
KM
Stierna
P
P
Carlsöö
B
B
D000818:Animals; D001441:Bacteroides fragilis / Q000472:pathogenicity; D008443:Maxillary Sinus / Q000473:pathology; D008444:Maxillary Sinus Neoplasms / Q000382:microbiology* / Q000473:pathology; D015523:Maxillary Sinusitis / Q000382:microbiology; D009297:Nasal Mucosa / Q000473:pathology; D009298:Nasal Polyps / Q000382:microbiology* / Q000473:pathology; D011127:Polyps / Q000382:microbiology* / Q000473:pathology; D011817:Rabbits; D013211:Staphylococcus aureus / Q000472:pathogenicity; D013296:Streptococcus pneumoniae / Q000472:pathogenicity; D014774:Virulence