Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene.
The effects of co-exposure of hexane and toluene were investigated in field surveys and animal experiments. One field survey suggested that increase of hexane content in adhesives might have caused an outbreak of polyneuropathy in a vinyl sandal manufacture in Japan. The animal experiments proved that co-exposure of hexane and toluene decrease hexane neurotoxicity and urinary excretion of hexane metabolites in rats. The results also suggested that toluene might inhibit metabolism of hexane. Another recent field survey indicated that the ratio of urinary 2,5-hexanedione to hexane exposure in the workers co-exposed to hexane and toluene decreased in parallel with in more crease of toluene concentration. The results indicated that urinary excretion of 2,5-hexanedione could be depressed by co-exposure of toluene even in the workers exposed to relatively low concentrations. These above-mentioned results suggest that co-exposure of hexane and toluene could inhibit hexane metabolism and decrease hexane neurotoxicity in both experimental animals and workers. Although metabolism of hexane could be easily modified by toluene or other solvents and might not be a good indicator for hexane exposure in mixed exposure, urinary 2,5-hexanedione might be a good indicator for neurotoxicity of hexane even in mixed exposure.
Takeuchi
Y
Y
Department of Hygiene, Nagoya University School of Medicine, Japan.
Hisanaga
N
N
Ono
Y
Y
Shibata
E
E
Saito
I
I
Iwata
M
M
D000269:Adhesives; D000293:Adolescent; D000818:Animals; D004347:Drug Interactions; D004784:Environmental Monitoring; D005260:Female; D006586:Hexanes / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006588:Hexanones / Q000652:urine; D006801:Humans; D009422:Nervous System Diseases / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D051381:Rats; D014050:Toluene / Q000032:analysis / Q000378:metabolism*
D000269:Adhesives; D006586:Hexanes; D006588:Hexanones; D014050:Toluene; C011269:2,5-hexanedione