[The treatment of cervical human papillomavirus (HPV) infection with trichloroacetic acid].
Ever since the alterations caused by the HPV on the cervix were discovered, countless treatments have been employed but the ideal method still remains unknown. The objective of the experiment was to assess the efficiency of handling the cervical infection caused by the HPV, by means of trichloroacetic acid, 85% rate. During the period comprised between April 1989 and March 1990, 60 patients were subject to close analysis. The general diagnosis drawn cytology, colposcopy, and histopathology was cervical condyloma, lacking any collateral evidence of intraepithelial cervical neoplasia. The treatment consisted of 3 weekly applications of trichloroacetic acid at 85% rate directly upon the cervix. They were all assessed through cytology and colposcopy every 3 months, during a year's period. After the first 3 months, a 73.4% healing rate was observed, which decreased to 68% after 6 months and to a 65% after 9 months; this last healing rate remained unchanged after 12 months. Pregnant patients showed higher healing rates. We have drawn the conclusions that the trichloroacetic acid is an efficient agent to treat the referred injuries, and it offers as well the advantages of low costs, no secondary effects and an easy application and handling.
Menéndez Velázquez
J F
JF
Clínica de Colposcopia, Hospital de Ginecobstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México, D.F.
González Sánchez
J L
JL
Rodríguez de Santiago
J D
JD
Muñoz Reyes
R
R
Bailón Uriza
R
R
D000328:Adult; D003127:Colposcopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D011446:Prospective Studies; D014238:Trichloroacetic Acid / Q000627:therapeutic use*; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D002577:Uterine Cervical Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology
D014238:Trichloroacetic Acid