title: The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients.
abstract: To ascertain the population structure of Candida albicans, we have carried out a multilocus enzyme electrophoresis study based on the analysis of 21 gene loci. We have thus characterized 55 strains isolated one each from 55 human immunodeficiency virus-positive patients. There is considerable polymorphism among the strains. A population-genetic analysis indicates that the two fundamental consequences of sexual reproduction (i.e., segregation and recombination) are apparently absent in this population of C. albicans. The population structure of C. albicans appears to be clonal, a state of affairs that has important medical and biological consequences.
authors.affiliation: Laboratoire d'Immunologie et Parasitologie, Faculté de Pharmacie, Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Pujol
authors.forename: J
authors.initials: J
authors.lastname: Reynes
authors.forename: F
authors.initials: F
authors.lastname: Renaud
authors.forename: M
authors.initials: M
authors.lastname: Raymond
authors.forename: M
authors.initials: M
authors.lastname: Tibayrenc
authors.forename: F J
authors.initials: FJ
authors.lastname: Ayala
authors.forename: F
authors.initials: F
authors.lastname: Janbon
authors.forename: M
authors.initials: M
authors.lastname: Mallié
authors.forename: J M
authors.initials: JM
authors.lastname: Bastide
mesh_terms: D002176:Candida albicans / Q000201:enzymology / Q000235:genetics / Q000254:growth & development*; D002177:Candidiasis / Q000382:microbiology*; D002999:Clone Cells; D008040:Genetic Linkage; D005828:Genetics, Population; D006679:HIV Seropositivity / Q000382:microbiology*; D006579:Heterozygote; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D011110:Polymorphism, Genetic
chemical_list: D007527:Isoenzymes