title: Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: the role in cancer progression.
abstract: Production of cathepsin B by tumor cells has been linked to metastatic potential in several experimental models. Sections of 95 primary lung adenocarcinomas were examined for expression of cathepsin B using a standard avidin-biotin immunohistochemical technique. Staining for cathepsin B was observed in 22.1% of all cases and 28.0% of those of the Clara cell type. In Clara cell adenocarcinomas, cathepsin B expression correlated with positive lymph node status, presence of distant metastases, and poor prognosis (P < 0.05). However, no correlation with clinical outcome was observed in other cell types. Our data suggest that cathepsin B may be involved in invasion and metastasis in Clara cell lung adenocarcinoma.
authors.affiliation: Department of Biochemistry, National Defense Medical College, Saitama.
authors.forename: Y
authors.initials: Y
authors.lastname: Ozeki
authors.forename: K
authors.initials: K
authors.lastname: Takishima
authors.forename: K
authors.initials: K
authors.lastname: Takagi
authors.forename: S
authors.initials: S
authors.lastname: Aida
authors.forename: S
authors.initials: S
authors.lastname: Tamai
authors.forename: G
authors.initials: G
authors.lastname: Mamiya
authors.forename: T
authors.initials: T
authors.lastname: Ogata
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002401:Cathepsin B / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged
chemical_list: D002401:Cathepsin B