Discriminative stimulus properties of (+)-oxaprotiline in rats.
Using a drug discrimination procedure on a fixed ratio (FR) 10 schedule of reinforcement, rats were trained to distinguish between the stimulus properties of the selective inhibitor of noradrenaline uptake (+)-oxaprotiline ((+)-OXA) and saline. Fifty per cent of the rats that learned to reliably discriminate (+)-OXA from saline, reached high discrimination accuracy. In substitution testing, maprotiline (MAP) and desipramine (DMI) produced dose-related responding on the (+)-OXA lever. (-)-OXA failed to show substitution. The results of our findings demonstrate that (+)-OXA may be used as a discriminative cue in rats. The NA uptake inhibition seems to be involved in the effect of this drug.
Filip
M
M
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Chojnacka-Wójcik
E
E
Przegaliński
E
E
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008376:Maprotiline / Q000031:analogs & derivatives* / Q000494:pharmacology; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013237:Stereoisomerism
D000928:Antidepressive Agents; D014179:Neurotransmitter Uptake Inhibitors; D008376:Maprotiline; C027299:hydroxymaprotilin; D009638:Norepinephrine