title: Use of a tourniquet in patients with sickle-cell disease.
abstract: Fifteen patients, 13 male and two female, known to be carrying the sickle-cell gene (12 HbSS and 3 HbAS), who were undergoing operations requiring a bloodless field, were included in the study. Of the 12 with HbSS, seven had haemoglobin A1 component of between 11 and 27%, three had fetal haemoglobin ranging from 5.7 to 29% and the remaining two had increased haemoglobin A2 concentrations suggesting a beta non-thalassaemia combination. All had a tourniquet applied to the appropriate limb and were given general anaesthesia with moderate hyperventilation throughout the procedure. The tourniquet inflation time was 61.7 +/- 27.5 min. The mean PaO2 remained above 200 mmHg, mean PaCO2 was less than 37 mmHg, and pH ranged between 7.40 and 7.45. There were no clinically important changes in BP or ECG. All patients made uneventful recoveries and none developed sickle-cell crises. It is suggested that it is safe to use tourniquet in patients with sickle-cell disease provided optimum acid-base status and oxygenation are maintained throughout the procedure.
authors.affiliation: Department of Anaesthesiology, King Faisal University, College of Medicine, Dammam, Saudi Arabia.
authors.forename: Y
authors.initials: Y
authors.lastname: Adu-Gyamfi
authors.forename: M
authors.initials: M
authors.lastname: Sankarankutty
authors.forename: S
authors.initials: S
authors.lastname: Marwa
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000235:genetics / Q000601:surgery*; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D003975:Diazepam / Q000008:administration & dosage; D004906:Erythrocyte Count; D004913:Erythrocytes, Abnormal / Q000473:pathology; D005121:Extremities / Q000601:surgery*; D005260:Female; D005838:Genotype; D006451:Hemoglobin, Sickle / Q000032:analysis / Q000235:genetics; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D011229:Preanesthetic Medication; D012805:Sickle Cell Trait / Q000097:blood / Q000235:genetics / Q000601:surgery*; D013997:Time Factors; D014111:Tourniquets
chemical_list: D006451:Hemoglobin, Sickle; D002245:Carbon Dioxide; D003975:Diazepam; D010100:Oxygen