Effect of lactate infusion on renal transport of purine bases and oxypurinol.
To investigate whether or not lactic acid inhibits the renal transport of oxypurines and oxypurinol, we administered physiological saline containing 0.2 mol sodium lactate to 5 normal subjects intravenously. Lactate infusion decreased the fractional clearance of uric acid, but the fractional clearances of hypoxanthine, xanthine and oxypurinol were not affected. These results suggest that uric acid and lactic acid share the renal transport system of organic acids but hypoxanthine, xanthine and oxypurinol do not. It is further suggested that allopurinol treatment is reasonable in subjects with hyperuricemia accompanied by hyperlactatemia since only the urinary excretion of uric acid and not oxypurines (hypoxanthine and xanthine) was inhibited by lactate infusion.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Moriwaki
Y
Y
Takahashi
S
S
Nasako
Y
Y
Higashino
K
K
D000328:Adult; D000493:Allopurinol / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000493:pharmacokinetics; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007773:Lactates / Q000008:administration & dosage* / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010117:Oxypurinol / Q000493:pharmacokinetics*; D011687:Purines / Q000493:pharmacokinetics* / Q000652:urine; D012709:Serum Albumin / Q000378:metabolism; D014527:Uric Acid / Q000097:blood / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000493:pharmacokinetics
D007042:Hypoxanthines; D007773:Lactates; D011687:Purines; D012709:Serum Albumin; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D019344:Lactic Acid; D000493:Allopurinol; D010117:Oxypurinol