3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.
Ghosh
A K
AK
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486.
Thompson
W J
WJ
McKee
S P
SP
Duong
T T
TT
Lyle
T A
TA
Chen
J C
JC
Darke
P L
PL
Zugay
J A
JA
Emini
E A
EA
Schleif
W A
WA
D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014520:Urethane / Q000031:analogs & derivatives*
D005663:Furans; D017320:HIV Protease Inhibitors; D008024:Ligands; D011714:Pyrans; D014520:Urethane