Helium-oxygen mixture in respiratory distress syndrome: a double-blind study.
In a randomized, controlled trial, the lungs of infants with respiratory distress syndrome were ventilated with either a helium-oxygen mixture or a nitrogen-oxygen mixture. In the helium-oxygen group, infants required a lower inspired oxygen concentration and a shorter duration of ventilation. There were also fewer deaths and fewer cases of bronchopulmonary dysplasia in the helium-oxygen group.
Elleau
C
C
Service de réanimation néonatale, Hôpital Pellegrin, France.
Galperine
R I
RI
Guenard
H
H
Demarquez
J L
JL
D000403:Airway Resistance; D001794:Blood Pressure; D001997:Bronchopulmonary Dysplasia / Q000209:etiology; D004311:Double-Blind Method; D006371:Helium / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D009584:Nitrogen / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood / Q000627:therapeutic use*; D001261:Pulmonary Atelectasis / Q000209:etiology; D012119:Respiration / Q000502:physiology; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome
D006371:Helium; C038949:heliox; D009584:Nitrogen; D010100:Oxygen