title: Indomethacin and recurrent ileal perforations in a preterm infant.
abstract: This article reports a case of a very low birth weight infant who was given intravenous indomethacin for a symptomatic patent ductus arteriosus and subsequently had two isolated ileal perforations several days apart. Spontaneous or indomethacin-related ileal perforation appears to constitute a separate clinical and pathologic entity, different from necrotizing enterocolitis, with a benign clinical picture and good prognosis when promptly recognized.
authors.affiliation: Department of Pediatrics, University of Oklahoma College of Medicine, Tulsa.
authors.forename: G P
authors.initials: GP
authors.lastname: Giacoia
authors.forename: K
authors.initials: K
authors.lastname: Azubuike
authors.forename: J R
authors.initials: JR
authors.lastname: Taylor
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000188:drug therapy; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced*; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007416:Intestinal Perforation / Q000139:chemically induced*; D008297:Male; D012008:Recurrence
chemical_list: D007213:Indomethacin