An irradiation-reduced hybrid panel for fine-structure mapping of the Xq28 region in the human genome.
Irradiation-reduced somatic cell hybrids containing fragments of the human X chromosome were constructed. Analysis of 16 hybrids that retained the Xq28 region with 12 Xq28-specific markers identified at least six different breakpoints, supporting the order cen-DXS304-DXS374-(DXS33, DXS134, DXS52, DXS15)-RCP-(DXS254, G6PD, F8C)-(DXS115, DXYS64)-qter. The generated panel of hybrids provides a useful tool for fine mapping of probes in the Xq28 region.
Peterlin
B
B
INSERM U-12, Hôpital des Enfants-Malades, Paris France.
Smahi
A
A
Holvoet-Vermaut
L
L
Heitz
D
D
Dahl
N
N
Hors-Cayla
M C
MC
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D005819:Genetic Markers; D015894:Genome, Human; D006801:Humans; D006822:Hybrid Cells / Q000528:radiation effects; D051379:Mice; D014960:X Chromosome
D005819:Genetic Markers