Metabolic capacity, fibre type area and capillarization of rat plantaris muscle. Effects of age, overload and training and relationship with fatigue resistance.
1. The influences of age (5, 13 and 25-month-old rats), overload as obtained by denervation of synergists, and training on the metabolic capacity, relative muscle cross-sectional area occupied by each fibre type, capillarization and fatigue resistance of the rat m. plantaris were investigated. 2. Creatine kinase, phosphorylase and citrate synthase activities were lower in muscles of 25 than in those of 13-month-old rats (P < 0.001). 3. Overload resulted in an increased relative area of type I and IIa fibres at all ages (P = 0.001). 4. Capillary density decreased with overload and increasing age (P < 0.001). 5. Fatigue resistance was higher in muscles of 13 than in those of 5-month-old rats (P < 0.05), and increased with overload (P < 0.05) at all ages. 6. Fatigue resistance of the whole muscle was not closely related to its oxidative capacity in contrast to what is generally found for single fibres or motor units.
Degens
H
H
Department of Physiology, University of Nijmegen, The Netherlands.
Veerkamp
J H
JH
van Moerkerk
H T
HT
Turek
Z
Z
Hoofd
L J
LJ
Binkhorst
R A
RA
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002196:Capillaries / Q000502:physiology; D003714:Denervation; D005260:Female; D066298:In Vitro Techniques; D009132:Muscles / Q000033:anatomy & histology / Q000098:blood supply / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar