[Antimicrobial activity of diazole-(N-salicylidene-L-alpha- alaninato)-copper complexes].
The antimicrobial activities of a group of copper(II) chelates with the composition [Cu(TSB)(L)] or [Cu(TSB)(L')]. (TSB = N-salicylidene-L-alpha-alaninate dianion, L = imidazole and its alkyl derivatives, L' = pyrazole and 3,5-dimethylpyrazole) were studied. Bis-diazole complexes with L' = pyrazole and 3,5-dimethylpyrazole were found to be the most active against S. aureus (MIC = 78 and 20 micrograms.cm-3), less effective against C. albicans (156 micrograms.cm-3), T. terrestre and M. gypseum (100 micrograms.cm-3). The observed biological properties of complexes are discussed in relation to their proposed structures.
Blahová
M
M
Katedra chemickej teórie lieciv a Katedra biochémie a mikrobiológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Sokolík
J
J
Sedlácková
S
S
Burianová
E
E
Mlynarcík
D
D
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000254:growth & development*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents