title: Central nervous system receptor binding profiles of some 2-amino-4-phenyl quinolines: a novel class of alpha 2-adrenoceptor selective ligands.
abstract: The 2-amino-4-phenyl quinoline moiety is a structural motif common to a number of central nervous system active agents. Extensive radio-ligand receptor binding profiles for several derivatives of this common structural feature have been determined. A high base level of central nervous system receptor affinity was observed with a distinct preference for the alpha-, and in particular the alpha 2-, adrenoceptors.
authors.affiliation: Department of Pharmaceutical Chemistry, Victorian College of Pharmacy, Parkville, Australia.
authors.forename: I A
authors.initials: IA
authors.lastname: Nicholls
authors.forename: S F
authors.initials: SF
authors.lastname: Morrison
authors.forename: R I
authors.initials: RI
authors.lastname: Brinkworth
authors.forename: P F
authors.initials: PF
authors.lastname: Alewood
authors.forename: P R
authors.initials: PR
authors.lastname: Andrews
mesh_terms: D000818:Animals; D002417:Cattle; D002490:Central Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D011804:Quinolines / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D011804:Quinolines; D018341:Receptors, Adrenergic, alpha-2