Exclusion mapping in familial non-specific dementia.
We present genetic linkage data in a large family in which non-specific dementia is inherited as an autosomal dominant trait. We have analyzed 45 highly polymorphic microsatellite sequences and excluded a quarter of the genome as the site of the pathogenic mutation in this family.
Brown
J
J
Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, UK.
Gydesen
S
S
Sorensen
S A
SA
Brun
A
A
Duff
K
K
Houlden
H
H
Fidani
L
L
Kullkarni
S
S
Cummings
J
J
Goate
A
A
D000328:Adult; D000368:Aged; D004276:DNA, Satellite / Q000032:analysis / Q000097:blood; D003704:Dementia / Q000235:genetics* / Q000473:pathology; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012984:Software
D004276:DNA, Satellite