title: Mitotic activity in expanded human skin.
abstract: In 20 patients subjected to breast reconstruction by means of tissue expansion, a skin biopsy was obtained at the vertex of the breast before and the day after expansion. Samples were incubated in [3H]thymidine, and the number of labeled cells were counted. A statistically significant rise in the number of labeled basal and suprabasal keratinocytes was seen after expansion. The findings suggest a net gain of tissue not only by stretching but also by formation of new tissue generated by tissue expansion.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Karolinska Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Olenius
authors.forename: C J
authors.initials: CJ
authors.lastname: Dalsgaard
authors.forename: M
authors.initials: M
authors.lastname: Wickman
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008938:Mitosis; D012867:Skin / Q000166:cytology*; D015626:Tissue Expansion