Value of preoperative bone and liver scans and alkaline phosphatase in the evaluation of breast cancer patients.
We reviewed the results of 133 bone scans and 63 liver scans (computed tomography, liver-spleen radionuclide scan, or ultrasonography) obtained for the preoperative evaluation of breast cancer patients. Information on the preoperative staging of breast cancer (TNM classification) was available in 131 of 133 patients. Bone scans had a low preoperative yield as only 4 of 133 patients (3%) had a positive bone scan that correlated with the results of plain films. Only 1 of 63 patients had a liver scan suggestive of possible metastasis. We also found that the alkaline phosphatase level was not a good predictor of bone or liver metastases in breast cancer patients. In 103 patients with normal bone scans, the majority (54%) had elevated alkaline phosphatase levels; conversely, 9 of 30 patients (30%) with abnormal scans had normal alkaline phosphatase levels. Furthermore, 51 of 63 patients (81%) with elevated alkaline phosphatase levels had normal liver scans. Approximately $74,000 was spent on these liver and bone scans.
Brar
H S
HS
Department of Surgery, Medical College of Georgia, Augusta 30912.
Sisley
J F
JF
Johnson
R H
RH
D000469:Alkaline Phosphatase / Q000097:blood*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary; D001943:Breast Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000601:surgery; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary; D009367:Neoplasm Staging / Q000379:methods; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011877:Radionuclide Imaging
D000469:Alkaline Phosphatase