title: Contralateral ovary in unilateral ovarian carcinoma: a search for preneoplastic lesions.
abstract: Contralateral ovaries from patients with unilateral ovarian carcinoma were examined and compared to ovaries from age-matched control patients without ovarian carcinoma. The number of inclusion cysts were increased in ovaries from patients with ovarian carcinoma compared to the controls (p < 0.01). In addition, inclusions from cases with ovarian carcinoma showed serous differentiation more frequently than the controls (p < 0.01; odds ratio = 10.0; 95% confidence interval = 1.2-78.1). An age-related increase in the number of inclusion cysts was seen in the study group but not in the control group. These findings support a role of surface inclusion cysts in the genesis of ovarian carcinoma.
authors.affiliation: Department of Pathology, Bellevue Hospital, New York, NY 10016.
authors.forename: K R
authors.initials: KR
authors.lastname: Mittal
authors.forename: A
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
authors.forename: J L
authors.initials: JL
authors.lastname: Cooper
authors.forename: R I
authors.initials: RI
authors.lastname: Demopoulos
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010048:Ovarian Cysts / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D010053:Ovary / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D012189:Retrospective Studies