title: Angiotensin sensitivity predicts aspirin benefit in placental insufficiency.
abstract: OBJECTIVE
  To determine whether the beneficial effects of aspirin in the treatment of Doppler umbilical placental insufficiency correlate with the maternal pressor response to angiotensin infusion.
  
  
  METHODS
  An open trial.
  
  
  METHODS
  A tertiary referral obstetric service.
  
  
  METHODS
  Women identified at between 25 and 36 weeks of pregnancy with an elevated umbilical artery Doppler systolic/diastolic (S/D) ratio and a positive pressor response to angiotensin infusion.
  
  
  METHODS
  Low dose aspirin (100mg/day) treatment of mothers.
  
  
  METHODS
  Fetal and placental size at delivery in relation to subsequent maternal angiotensin responsiveness.
  
  
  RESULTS
  Women who converted from a positive angiotensin pressor response to angiotensin refractoriness after aspirin administration had larger infants and placentas compared with those whose response remained positive.
  
  
  CONCLUSIONS
  Angiotensin sensitivity predicts women with umbilical Doppler detected placental insufficiency responding to aspirin therapy. Loss of the normal refractory response in pregnancy may be a consequence of vascular pathology in the placenta.
authors.forename: C M
authors.initials: CM
authors.lastname: Cook
authors.forename: B J
authors.initials: BJ
authors.lastname: Trudinger
mesh_terms: D000809:Angiotensins / Q000378:metabolism*; D001241:Aspirin / Q000627:therapeutic use*; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D010927:Placental Insufficiency / Q000188:drug therapy* / Q000378:metabolism; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors
chemical_list: D000809:Angiotensins; D001241:Aspirin