title: Facial skeletal augmentation using hydroxyapatite cement.
abstract: This study investigates the use of a new calcium phosphate cement, which sets to solid, microporous hydroxyapatite, for facial bone augmentation. In six dogs, the supraorbital ridges were augmented bilaterally with this hydroxyapatite cement. On one side, the hydroxyapatite cement was placed directly onto the bone within a subperiosteal pocket. On the opposite side, the cement was contained within a collagen membrane tubule and then inserted into a subperiosteal pocket. The use of collagen tubules facilitated easy, precise placement of the cement. All implants maintained their original augmented height throughout the duration of the study. They were well tolerated without extrusion or migration, and there was no significant sustained inflammatory response. Histologic studies, performed at 3, 6, and 9 months revealed that when the cement was placed directly onto bone, progressive replacement of the implant by bone (osseointegration of the hydroxyapatite with the underlying bone) without a loss of volume was observed. In contrast, when the cement-collagen tubule combination was inserted, primarily a fibrous union was noted. Despite such fibrous union, the hydroxyapatite-collagen implant solidly bonded to the underlying bone, and no implant resorption was observed. Hydroxyapatite cement can be used successfully for the experimental augmentation of the craniofacial skeleton and may be applicable for such uses in humans.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Southern California, Los Angeles 90033-4605.
authors.forename: M L
authors.initials: ML
authors.lastname: Shindo
authors.forename: P D
authors.initials: PD
authors.lastname: Costantino
authors.forename: C D
authors.initials: CD
authors.lastname: Friedman
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000008:administration & dosage / Q000627:therapeutic use; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005147:Facial Bones / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D006882:Hydroxyapatites / Q000494:pharmacology / Q000627:therapeutic use*; D010012:Osteogenesis; D013518:Surgery, Plastic / Q000379:methods / Q000592:standards; D013997:Time Factors
chemical_list: D001843:Bone Cements; D006882:Hydroxyapatites; D003094:Collagen