title: Quantification of inhomogeneities in malignancy grading of non-Hodgkin lymphoma with MR imaging.
abstract: In a previous study of 50 patients with non-Hodgkin lymphoma (NHL) it was shown that the inhomogeneous appearance of a tumor at MR imaging strongly indicated a high malignancy grade. In this study of 33 patients with NHL, the administration of an i.v. contrast medium, Gadolinium-DTPA, improved the subjective detectability of the inhomogeneities. A method of quantifying the degree of inhomogeneity in the tumors (inhomogeneity index, IH-index) was developed and tested. The mean value of IH-index in the T2-weighted image before contrast medium administration, and of the T1-weighted image after contrast medium administration, as well as the IH-index value in the T2-weighted image before contrast medium administration alone, was able to discriminate well between low- and high-grade NHL. This method of quantifying the degree of inhomogeneity in tumors improved sensitivity in detecting high-grade NHL.
authors.affiliation: Department of Oncology, University Hospital, Uppsala, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Rehn
authors.forename: G O
authors.initials: GO
authors.lastname: Sperber
authors.forename: R
authors.initials: R
authors.lastname: Nyman
authors.forename: B
authors.initials: B
authors.lastname: Glimelius
authors.forename: H
authors.initials: H
authors.lastname: Hagberg
authors.forename: A
authors.initials: A
authors.lastname: Hemmingsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008961:Models, Structural; D009942:Organometallic Compounds; D004369:Pentetic Acid; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA