title: Improved cine MR imaging of left ventricular wall motion with gadopentetate dimeglumine.
abstract: The assessment of left ventricular wall motion with cine magnetic resonance imaging in the cardiac long axes is useful; however, image quality is limited by reduced signal intensity due to saturation of blood flowing predominantly in plane. Twenty subjects were studied to evaluate the effects of gadopentetate dimeglumine on contrast between blood and myocardium. Contrast improved significantly on contrast agent-enhanced images in the long axes, at both end-systole (vertical axis, +62%, P < .0001; horizontal axis, +67%, P < .0001) and end-diastole (vertical axis, +50%, P < .0001; horizontal axis, +26%, P < .004). The increase in the short axis was less and significant only at end-systole (+25%, P < .0001). Subjective scoring of the cines also showed a significant and clinically useful improvement in the long axes (P < .0001 for both) on contrast-enhanced images. Improved contrast was most evident for 10 minutes after injection, but persisted for up to 20 minutes at end-systole in the long axes. Gadopentetate dimeglumine is useful for cine imaging of left ventricular wall motion when saturation effects prevent adequate clinical assessment.
authors.affiliation: Magnetic Resonance Unit, Royal Brompton National Heart and Lung Hospitals, London, United Kingdom.
authors.forename: D J
authors.initials: DJ
authors.lastname: Pennell
authors.forename: S R
authors.initials: SR
authors.lastname: Underwood
authors.forename: D B
authors.initials: DB
authors.lastname: Longmore
mesh_terms: D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds; D004369:Pentetic Acid; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA