title: Female urinary stress incontinence in terms of connective tissue biochemistry.
abstract: The role of connective tissue in the aetiology of female stress incontinence has been investigated. Collagen content and extractability as well as estrogen receptor concentration in vesico-vaginal fascia were measured after small tissue biopsies had been obtained during vaginal repair surgery in cases of urinary incontinence. The mean concentration of estrogen receptor in vesico-vaginal fascia among incontinent women was 49.4 +/- 14.8 fmol/mg of protein as compared to 29.6 +/- 13.1 in continent control group (P < 0.03; t-test). The mean hydroxyproline concentration in vesico-vaginal fascia of incontinent women was 13.8 +/- 2.6 micrograms/mg wet weight, whereas in the control group it was significantly higher 20.6 +/- 2.4 (P < 0.001). The role of connective tissue components in the aetiology of female stress incontinence is discussed.
authors.affiliation: II Clinic of Gynecological Surgery, Medical Academy of Lublin, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Rechberger
authors.forename: H
authors.initials: H
authors.lastname: Donica
authors.forename: W
authors.initials: W
authors.lastname: Baranowski
authors.forename: J
authors.initials: J
authors.lastname: Jakowicki
mesh_terms: D001696:Biomechanical Phenomena; D003094:Collagen / Q000032:analysis*; D003238:Connective Tissue / Q000737:chemistry*; D004967:Estrogens / Q000172:deficiency; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis; D012995:Solubility; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000378:metabolism*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen; D003094:Collagen