[Clonal change of HTLV-1 infected lymphocytes before onset of adult T-cell leukemia/lymphoma].
A 73-year-old HTLV-1 infected male developed overt ATL following 3-years observation, and the clonality of HTLV-1 infected cells changed before overt ATL onset. 10 micrograms of DNA, extracted from mononuclear cells was digested with PstI, and the clonal proliferation of HTLV-1 infected cells was examined by Southern blotting with LTR probe. 4 bands were observed 3 years prior to ATL onset, and 2 different bands were detected 2 years and 6 months later. This suggests that in some ATL cases, the clonality of monoclonally proliferated HTLV-1 infected cells may be changeable before overt ATL onset.
Furukawa
Y
Y
Department of Internal Medicine, Kagosima City Hospital.
Tara
M
M
Niina
K
K
Kubo
H
H
Imaguma
M
M
D000368:Aged; D002999:Clone Cells; D005500:Follow-Up Studies; D015490:HTLV-I Infections / Q000150:complications / Q000473:pathology*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000209:etiology / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D013997:Time Factors