Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion.
A group of women were fed two separate diets in a crossover study and urinary eicosanoids were quantified. One diet contained 3.1% of total energy (en%) as polyunsaturated fatty acids (3.0 en% linoleic acid) and the other contained 8.4 en% polyunsaturated fatty acids (8.3 en% linoleic acid). Carbohydrate replaced fat in the low-polyunsaturated-fat diet. No changes were observed in the urinary excretion of 6-oxo-prostaglandin F1 alpha, its 2,3-dinor metabolite or thromboxane B2 by subjects on either of the diets. Urinary 2,3-dinor-thromboxane B2 excretion was lower (206.5 ng/24 h) when subjects were fed the high-omega 6 polyunsaturated fatty acid diet when compared with the lower-omega 6 polyunsaturated fatty acid diet (275.3 ng/24 h). Conversely, urinary prostaglandin E2 was higher (139.2 ng/g creatinine) during the higher-omega 6 polyunsaturated fatty acid diet when compared with the lower-omega 6 polyunsaturated fatty acid diet (94.4 ng/g creatinine).
Blair
I A
IA
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232.
Prakash
C
C
Phillips
M A
MA
Dougherty
R M
RM
Iacono
J M
JM
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D002855:Chromatography, Thin Layer; D004041:Dietary Fats / Q000008:administration & dosage*; D015232:Dinoprostone / Q000652:urine; D015777:Eicosanoids / Q000652:urine*; D002149:Energy Intake; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage; D008875:Middle Aged; D013929:Thromboxane B2 / Q000031:analogs & derivatives / Q000652:urine
D004041:Dietary Fats; D015777:Eicosanoids; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C028965:2,3-dinor-thromboxane B2; D019787:Linoleic Acid; D015232:Dinoprostone