title: The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family.
abstract: We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.
authors.affiliation: Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Lomeli
authors.forename: R
authors.initials: R
authors.lastname: Sprengel
authors.forename: D J
authors.initials: DJ
authors.lastname: Laurie
authors.forename: G
authors.initials: G
authors.lastname: Köhr
authors.forename: A
authors.initials: A
authors.lastname: Herb
authors.forename: P H
authors.initials: PH
authors.lastname: Seeburg
authors.forename: W
authors.initials: W
authors.lastname: Wisden
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D004247:DNA; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017459:Receptors, Amino Acid / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
chemical_list: D012333:RNA, Messenger; D017459:Receptors, Amino Acid; D004247:DNA