Concentration of free calcium in erythrocytes of lead-depleted rats.
The concentration of Ca(2+)-ions in erythrocytes of lead-depleted rats was estimated using the fluorescent Ca(2+)-indicator fura-2. The lead-depleted animals of the F1 generation showed an elevated Ca(2+)-concentration, whereas in the Po generation there was no difference in the Ca(2+)-concentration between depletion and control group. The elevation of Ca(2+)-ion concentration of lead-depleted rats could be caused by a reduction in Ca-Mg-ATPase activity in lead-depletion and could possibly lead to a decreased mean corpuscular volume (MCV) of erythrocytes.
Loipführer
A M
AM
Institut für Ernährungsphysiologie, Technische Universität München-Weihenstephan, Freising, Fed. Rep. of Germany.
Reichlmayr-Lais
A M
AM
Kirchgessner
M
M
D000818:Animals; D002118:Calcium / Q000097:blood*; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D005453:Fluorescence; D016257:Fura-2; D007854:Lead / Q000172:deficiency* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D007854:Lead; D002118:Calcium; D016257:Fura-2