Case report: acyclovir neurotoxicity and nephrotoxicity--the role for hemodialysis.
Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.
Krieble
B F
BF
Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis.
Rudy
D W
DW
Glick
M R
MR
Clayman
M D
MD
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000212:Acyclovir / Q000633:toxicity* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D009498:Neurotoxins; D006435:Renal Dialysis
D009498:Neurotoxins; D000212:Acyclovir