Relation of plasma and red blood cells reduced haloperidol concentrations to haloperidol reductase activity assayed in red blood cells in psychiatric population.
1. Haloperidol (HAL) reductase activity in red blood cells (RBC) was determined by a newly developed assay method in 120 blood samples from 75 Japanese psychiatric patients receiving HAL. 2. Plasma concentrations of HAL and reduced haloperidol (RHAL), a reductive metabolite of haloperidol, were also measured in these samples. 3. RBC concentrations of HAL and RHAL were measured in 62 of these samples. 4. No significant correlations were found between HAL reductase activity in RBC vs plasma or RBC RHAL/HAL ratios, which may represent activity of the enzyme metabolizing HAL into RHAL. 5. RHAL concentrations were three times higher in RBC than in plasma, though HAL concentrations were at the same level in both tissues. This may reflect accumulation of RHAL in RBC.
Shibasaki
M
M
Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
Someya
T
T
Takahashi
S
S
D000293:Adolescent; D000328:Adult; D000429:Alcohol Oxidoreductases / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006220:Haloperidol / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000097:blood*
C040692:4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol; D000429:Alcohol Oxidoreductases; C063466:haloperidol reductase; D006220:Haloperidol