An interaction of beta-amyloid with aluminium in vitro.
We have used circular dichroism spectroscopy to confirm that, in a membrane-mimicking solvent, A beta P(1-40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and beta-amyloid and may have important implications for the pathogenesis of Alzheimer's disease.
Exley
C
C
Department of Chemistry, Keele University, Staffordshire, UK.
Price
N C
NC
Kelly
S M
SM
Birchall
J D
JD
D000535:Aluminum / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002942:Circular Dichroism; D006801:Humans; D066298:In Vitro Techniques; D010455:Peptides / Q000737:chemistry; D017433:Protein Structure, Secondary
D016229:Amyloid beta-Peptides; D010455:Peptides; D000535:Aluminum