Immunological changes in the MPTP-induced Parkinson's disease mouse model.
The role of the central dopaminergic system in modulating immune response is not completely established. We examined the influence of central dopamine depletion on selected parameters of immune functions in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated and untreated mice. IgM antibody production of splenocytes to sheep red blood cells was reduced in MPTP-treated mice (P < 0.001). Proliferation of splenocytes in response to a wide range of mitogen concentrations (Concanavalin A, phytohaemagglutinin, lipopolysaccharide) was also significantly diminished in MPTP-treated mice. Production of migration inhibition factor (MIF) was diminished only in low mitogen concentration. Our results obtained in the experimental model of Parkinson's disease provide evidence that the damage of the central dopaminergic pathways induces alterations of some immune functions in mice.
Bieganowska
K
K
Institute of Psychiatry and Neurology, Warsaw, Poland.
Członkowska
A
A
Bidziński
A
A
Mierzewska
H
H
Korlak
J
J
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D000921:Antibody-Producing Cells; D002464:Cell Migration Inhibition; D003342:Corpus Striatum / Q000737:chemistry / Q000473:pathology; D004195:Disease Models, Animal; D004298:Dopamine / Q000032:analysis; D006462:Hemolytic Plaque Technique; D007150:Immunohistochemistry; D008213:Lymphocyte Activation; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration; D010302:Parkinson Disease, Secondary / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013378:Substantia Nigra / Q000502:physiology
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine