Lepromin skin testing in the classification of Hansen's disease in the United States.
Hansen's disease, or leprosy, although a relatively uncommon disease in the United States, continues to be important because of its implications--physical, psychological, and social--for the patient. Prognosis and treatment of the disease are based largely on clinical classification, which ranges from the multibacillary "lepromatous" to the paucibacillary "tuberculoid" forms, depending on the patient's specific immune capabilities. Traditionally, skin testing with lepromins--suspensions of the etiologic agent of Hansen's disease, Mycobacterium leprae--have been used as adjuncts to clinical parameters for classification in endemic areas. However, these have not been systematically studied in the United States. This report describes the results obtained from skin testing 38 volunteers (22 patients and 16 uninfected persons) with standard lepromin preparations. These results support the adjunctive value of lepromins for clinically classifying Hansen's disease in our "hypoendemic" population.
Krotoski
W A
WA
Laboratory Research Branch, Gillis W. Long Hansen's Disease Center, Carville, Louisiana.
Mroczkowski
T F
TF
Rea
T H
TH
Almodovar
P I
PI
Clements
B C
BC
Neimes
R E
RE
Kahkonen
M K
MK
Job
C K
CK
Hastings
R C
RC
D000818:Animals; D001135:Armadillos; D006801:Humans; D007916:Lepromin; D007918:Leprosy / Q000175:diagnosis*; D012882:Skin Tests; D014481:United States
D007916:Lepromin