Suppression of adjuvant-induced arthritis in DA rats by incomplete Freund's adjuvant.
OBJECTIVE
To define the effects of incomplete Freund's adjuvant (ICFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type II collagen (CII) in DA and Lewis rats.


METHODS
ICFA was injected into DA and Lewis rats before CFA or CII injection.


RESULTS
DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P < 0.01). ICFA had no significant impact on CFA-induced arthritis in Lewis rats or on CII-induced arthritis in DA rats.


CONCLUSIONS
The injection of ICFA alone specifically suppresses subsequent CFA-induced arthritis in DA rats, but not in Lewis rats.
Cannon
G W
GW
Salt Lake City Veterans Affairs Medical Center, UT.
Griffiths
M M
MM
Woods
M L
ML
D000818:Animals; D001169:Arthritis, Experimental / Q000517:prevention & control*; D005069:Evaluation Studies as Topic; D005620:Freund's Adjuvant / Q000494:pharmacology*; D007271:Injections, Intradermal; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley
D005620:Freund's Adjuvant