title: Cocaine use in women from a defined population: prevalence at delivery and effects on growth in infants.
abstract: Adverse health effects associated with intrauterine cocaine exposure (prematurity and its associated morbidity, intrauterine growth retardation, possible risk of sudden infant death syndrome) are based on studies from large urban hospitals, but few data exist from other sources. The current study, set in a community hospital, was designed to (1) estimate the prevalence of maternal cocaine use at delivery, (2) describe neonatal outcomes, and (3) evaluate physiological growth in exposed children. The study was conducted over 30 months (total births were 14,074) at The Children's Hospital of Greenville Memorial Hospital, the major source of neonatal care for Greenville County, South Carolina (1990 population: 320,000). A child was considered exposed to cocaine if there was documented evidence of use in the mother's medical record or if one member of the pair had a positive urine drug screen. Growth data were abstracted from clinical records. Overall prevalence of exposure was 1.0%. Of the 137 subjects (89, positive urine drug screen; 48 self-reported exposure), 21 (15%, 95% confidence interval, 9% to 21%) were premature (gestational age < 37 weeks) and 2 died of sudden infant death syndrome. Mean age- and sex-adjusted percentiles for weight, length, and head circumference increased from 23%, 29%, and 18%, respectively, at birth to 43%, 49%, and 54% in children followed for 12 months; however, 50% of the cohort were lost to follow-up, and these children were smaller at birth than those under active follow-up. Rates of prematurity and infant death were similar to those reported in urban hospitals.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, Greenville Hospital System, SC 29605.
authors.forename: W T
authors.initials: WT
authors.lastname: Weathers
authors.forename: M M
authors.initials: MM
authors.lastname: Crane
authors.forename: K J
authors.initials: KJ
authors.lastname: Sauvain
authors.forename: D W
authors.initials: DW
authors.lastname: Blackhurst
mesh_terms: D000328:Adult; D003042:Cocaine; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D006764:Hospitals, Community; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening; D007752:Obstetric Labor, Premature / Q000139:chemically induced / Q000453:epidemiology; D011159:Population Surveillance; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000652:urine; D011256:Pregnancy Outcome; D015995:Prevalence; D013022:South Carolina / Q000453:epidemiology; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000150:complications / Q000453:epidemiology* / Q000652:urine
chemical_list: D003042:Cocaine