Effect of mannose-binding protein on binding of Cryptococcus neoformans to human phagocytes.
The capacity of human peripheral blood monocytes, neutrophils, and monocyte-derived macrophages to bind the yeast Cryptococcus neoformans was increased when the phagocytes were cultured on surfaces containing recombinant human mannose-binding protein. In contrast, soluble mannose-binding protein had no effect on cryptococcal binding by phagocytes.
Levitz
S M
SM
Evans Memorial Department of Clinical Research, Boston, Massachusetts.
Tabuni
A
A
Treseler
C
C
D000268:Adhesiveness; D002352:Carrier Proteins / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000276:immunology*; D006801:Humans; D008358:Mannose / Q000378:metabolism*; D037241:Mannose-Binding Lectins; D010586:Phagocytes / Q000382:microbiology / Q000502:physiology*; D010587:Phagocytosis; D011994:Recombinant Proteins / Q000494:pharmacology
D002352:Carrier Proteins; D037241:Mannose-Binding Lectins; D011994:Recombinant Proteins; D008358:Mannose