title: The fibroblast growth factor receptor 3 gene (FGFR3) is assigned to human chromosome 4.
abstract: Fibroblast growth factor receptors (FGFRs) have recently been isolated and shown to be transmembrane tyrosine kinase receptors. The FGFR1 gene has previously been assigned to human chromosome 8 and the FGFR4 gene to human chromosome 5. Here we demonstrate, by using somatic cell hybrids, that the FGFR3 gene localizes to human chromosome 4, showing that it, too, resides on a chromosome distinct from those on which other FGFRs have been localized.
authors.affiliation: Department of Microbiology, School of Medicine, State University of New York, Stony Brook 11794-8621.
authors.forename: K
authors.initials: K
authors.lastname: Keegan
authors.forename: L
authors.initials: L
authors.lastname: Rooke
authors.forename: M
authors.initials: M
authors.lastname: Hayman
authors.forename: N K
authors.initials: NK
authors.lastname: Spurr
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002894:Chromosomes, Human, Pair 4; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D011505:Protein-Tyrosine Kinases; D051498:Receptor, Fibroblast Growth Factor, Type 3; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D015342:DNA Probes; D017468:Receptors, Fibroblast Growth Factor; C496365:FGFR3 protein, human; C496366:Fgfr3 protein, mouse; D011505:Protein-Tyrosine Kinases; D051498:Receptor, Fibroblast Growth Factor, Type 3