Effect of an anticalculus toothpaste containing pyrophosphate on pyrophosphatase activity and the state of calcium phosphate in saliva.
Experiments were performed to determine if a pyrophosphate-containing anticalculus toothpaste could affect certain salivary constituents involved in the mineralization of dental plaque. The findings indicated no obvious changes in acid and alkaline pyrophosphatases, ionized calcium, total calcium, inorganic phosphate or pH in saliva for 1-135 min after brushing the teeth with the anticalculus toothpaste. Data obtained by brushing with the toothpaste three times daily for two weeks also confirmed these results. Our findings clearly indicate that pyrophosphate-stabilizing agents in the anticalculus toothpaste are not fully effective in the oral cavity. In addition, the pyrophosphate-containing toothpaste has no influence on the state of calcium and phosphate in saliva.
Koontongkaew
S
S
Department of Oral Biology and Occlusion, Faculty of Dentistry, Prince of Songkla University, Thailand.
Surarit
R
R
Phantumvanit
P
P
D000328:Adult; D000704:Analysis of Variance; D002118:Calcium / Q000032:analysis; D002130:Calcium Phosphates / Q000032:analysis*; D003728:Dental Calculus / Q000517:prevention & control*; D011756:Diphosphates / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D015999:Multivariate Analysis; D011755:Pyrophosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D016037:Single-Blind Method; D014100:Toothpastes / Q000494:pharmacology* / Q000627:therapeutic use
D002130:Calcium Phosphates; D011756:Diphosphates; D014100:Toothpastes; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D011755:Pyrophosphatases; C485829:calcium phosphate, dibasic, anhydrous; D002118:Calcium