Octreotide, a long-acting somatostatin analog, in the management of postoperative dumping syndrome. An update.
Severe long-term complaints of dumping occur in a small number of patients after gastric surgery. Dietary modification, fiber preparations, and medical therapy are often ineffective. In these severely affected patients administration of the somatostatin analog octreotide before meals appears to be a promising new strategy. The effects of octreotide on both gastrointestinal transit time and hormonal changes appear to contribute to the benefits seen in dumping syndrome. However, as the majority of studies conducted have employed only a single dose of octreotide, careful long-term assessment of the nutritional and metabolic effects will be required. Recent results suggest that octreotide may be administered up to 2 hr before a meal and therefore has a sufficiently long duration of action to be of practical long-term use. Moreover, general improvements in life-style, as well as beneficial effects on symptoms, have been reported with long-term treatment, although the potential development of diarrhea will require careful monitoring. The development of an oral or nasal formulation should further improve the practical application of octreotide as a treatment for dumping syndrome.
Lamers
C B
CB
Department of Gastroenterology, University Hospital Leiden, The Netherlands.
Bijlstra
A M
AM
Harris
A G
AG
D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004377:Dumping Syndrome / Q000188:drug therapy* / Q000209:etiology; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D015282:Octreotide