Molecular mechanisms of hematologic malignancies.
This article reviews both the role of signal transduction in human cancer and the recently uncovered molecular mechanisms involved in a large number of human hematologic malignancies. Chronic myelogenous leukemia, follicular lymphoma, and colorectal carcinoma are used as models to illustrate the different, as well as partly convergent, molecular pathways involved in the multistep process of human neoplasias. Examples are also provided as to how unique molecular markers can be used as fast, sensitive, and precise tools for cancer prevention, early diagnosis, and the management of residual disease.
Yunis
J J
JJ
Department of Neoplastic Diseases, Hahnemann University, Philadelphia, PA 19102-1192.
Tanzer
J
J
D001483:Base Sequence; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D003110:Colonic Neoplasms / Q000235:genetics; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D008223:Lymphoma / Q000235:genetics*; D008224:Lymphoma, Follicular; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D012004:Rectal Neoplasms / Q000235:genetics; D015398:Signal Transduction; D014178:Translocation, Genetic