title: Cytogenetic findings in 20 melanomas.
abstract: We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. We compare our results with the data reported in the literature and discuss the possible role of the cytogenetic analyses in human malignant melanoma.
authors.affiliation: Cattedra di Genetica Medica, Università degli Studi, La Sapienza, Roma, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Grammatico
authors.forename: C
authors.initials: C
authors.lastname: Catricalà
authors.forename: C
authors.initials: C
authors.lastname: Potenza
authors.forename: A
authors.initials: A
authors.lastname: Amantea
authors.forename: M
authors.initials: M
authors.lastname: Roccella
authors.forename: F
authors.initials: F
authors.lastname: Roccella
authors.forename: L
authors.initials: L
authors.lastname: Eibenschutz
authors.forename: G
authors.initials: G
authors.lastname: Del Porto
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D005819:Genetic Markers