Early events following challenge of rabbits with Trypanosoma evansi and T. evansi components.
The intradermal injection of Trypanosoma evansi or T. evansi components into rabbits evoked trypanosome-specific responses in the skin. The strongest responses, which were those against the parasite surface-associated components, had the characteristics of an immediate type hypersensitivity reaction, followed by a delayed type. The responses were greater in rabbits from which infections had been cleared by chemotherapy than in animals with patient infections. These findings suggest that variant surface glycoprotein (VSG)-specific antibody activity and immunosuppression are effective in the skin and influence the outcome of infection with T. evansi in previously infected animals.
Uche
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Centre for Tropical Veterinary Medicine, Midlothian, Scotland, UK.
Jones
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D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000917:Antibody Formation; D000953:Antigens, Protozoan / Q000276:immunology / Q000494:pharmacology*; D001706:Biopsy; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000469:parasitology*; D007165:Immunosuppression Therapy; D007279:Injections, Subcutaneous; D008854:Microscopy, Electron; D011817:Rabbits; D012867:Skin / Q000469:parasitology / Q000473:pathology / Q000648:ultrastructure; D013997:Time Factors; D014345:Trypanosoma / Q000276:immunology* / Q000502:physiology; D014352:Trypanosomiasis / Q000276:immunology / Q000473:pathology; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000276:immunology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D014643:Variant Surface Glycoproteins, Trypanosoma