Use of vancomycin in vitrectomy infusion solution and evaluation of retinal toxicity.
The retinal toxicity of vancomycin in infusion solution used in vitrectomy and lensectomy was investigated in rabbit eyes by means of electroretinography and histologic study (light microscopy). Concentrations of 8 micrograms/ml, 16 micrograms/ml, and 32 micrograms/ml of vancomycin in balanced salt solution caused no abnormal ERG or histologic changes. However, ERG amplitude depression and abnormal histologic changes occurred when the concentration of 100 micrograms/ml of vancomycin was used.
Borhani
H
H
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112-2234.
Peyman
G A
GA
Wafapoor
H
H
D000818:Animals; D002387:Cataract Extraction; D003623:Dark Adaptation; D004596:Electroretinography / Q000187:drug effects; D007552:Isotonic Solutions; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D014640:Vancomycin / Q000008:administration & dosage / Q000633:toxicity*; D014821:Vitrectomy
D007552:Isotonic Solutions; D009883:Ophthalmic Solutions; D014640:Vancomycin