title: Semi-automated cervical smear pre-screening systems: an evaluation of the Cytoscan-110.
abstract: This paper reports a test of a system for provision of machine assistance in cervical cytology screening. The hypothesis tested was that if the results of examination by a screener of a small number of high-ploidy cells on specially prepared monolayers, automatically selected and presented by the system, were combined with machine measurement of cell and cell population characteristics, it would be possible to distinguish conditions requiring further action on the part of a cytology service from those in which the patient could safely be signed out. The system appeared broadly capable of this discrimination, with a false-negative error not significantly different (for the numbers tested) on CIN1 and more severe cases to that obtaining for routine screening of the parallel PAP smears, and also to results obtained by a panel of three observers. The machine system appeared to do better than other systems in selecting borderline cases for review, but this may have been an artefact of the method of evaluation used: all results were compared with a 'reference diagnosis', which was computed using statistical techniques to integrate diagnostic information from all available sources. The false-negative error-rate of the system amounted to 5% of high-grade cases, 17% of CIN1's and 29% of borderlines, but were not substantially different from the FN rates for other reporting systems on the same material. The proportion of negative cases referred back for full cytological diagnosis was 34%. Despite this high false-positive rate, the system is potentially cost-effective in use.
authors.affiliation: Department of Cytology, Charing Cross Hospital, London, UK.
authors.forename: O A
authors.initials: OA
authors.lastname: Husain
authors.forename: K C
authors.initials: KC
authors.lastname: Watts
authors.forename: F
authors.initials: F
authors.lastname: Lorriman
authors.forename: B
authors.initials: B
authors.lastname: Butler
authors.forename: J
authors.initials: J
authors.lastname: Tucker
authors.forename: A
authors.initials: A
authors.lastname: Carothers
authors.forename: P
authors.initials: P
authors.lastname: Eason
authors.forename: S
authors.initials: S
authors.lastname: Farrow
authors.forename: D
authors.initials: D
authors.lastname: Rutovitz
authors.forename: M
authors.initials: M
authors.lastname: Stark
mesh_terms: D001331:Automation; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D065006:Papanicolaou Test; D011237:Predictive Value of Tests; D012015:Reference Standards; D013048:Specimen Handling / Q000379:methods; D014626:Vaginal Smears / Q000191:economics / Q000379:methods*