Tuberculosis--immunopathogenesis and therapy.
Infection with Mycobacterium tuberculosis (TB) has returned to the forefront of public and medical concern because of the recent sharp increase in the number of cases. Major strides have been made in understanding the pathogenesis of TB, and some of these basic advances are being applied clinically. This review focuses on current concepts of the host response to TB, the changing epidemiology of TB, and optimal treatment strategies.
Weissler
J C
JC
Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas 75235-9034.
D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry; D015342:DNA Probes; D004269:DNA, Bacterial / Q000235:genetics; D015658:HIV Infections / Q000150:complications; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D016133:Polymerase Chain Reaction; D044469:Racial Groups; D012307:Risk Factors; D013997:Time Factors; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000628:therapy; D014481:United States
D000942:Antigens, Bacterial; D015342:DNA Probes; D004269:DNA, Bacterial; D006360:Heat-Shock Proteins