title: Use of vancomycin in vitrectomy infusion solution and evaluation of retinal toxicity.
abstract: The retinal toxicity of vancomycin in infusion solution used in vitrectomy and lensectomy was investigated in rabbit eyes by means of electroretinography and histologic study (light microscopy). Concentrations of 8 micrograms/ml, 16 micrograms/ml, and 32 micrograms/ml of vancomycin in balanced salt solution caused no abnormal ERG or histologic changes. However, ERG amplitude depression and abnormal histologic changes occurred when the concentration of 100 micrograms/ml of vancomycin was used.
authors.affiliation: LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112-2234.
authors.forename: H
authors.initials: H
authors.lastname: Borhani
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
authors.forename: H
authors.initials: H
authors.lastname: Wafapoor
mesh_terms: D000818:Animals; D002387:Cataract Extraction; D003623:Dark Adaptation; D004596:Electroretinography / Q000187:drug effects; D007552:Isotonic Solutions; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D014640:Vancomycin / Q000008:administration & dosage / Q000633:toxicity*; D014821:Vitrectomy
chemical_list: D007552:Isotonic Solutions; D009883:Ophthalmic Solutions; D014640:Vancomycin