Amphotericin B therapy in kala-azar.
Twenty-seven adult patients of kala-azar unresponsive to sodium stibogluconate (SSG) were given amphotericin B in the dose schedule of 0.50 mg/kg body weight on alternate days for a total of 21 to 31 infusions, depending upon clinical and parasitological response. A 100% cure rate was achieved at the end of the therapy and no relapse was encountered during 12 months follow-up. Only mild adverse reactions were noted on the day of infusion during therapy. Amphotericin B was found to be an acceptable alternative drug for treatment of such cases.
Giri
O P
OP
Department of Medicine, Darbhanga Medical College and Hospital, Laherisarai.
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007194:India; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D012008:Recurrence
D000666:Amphotericin B