Whole inactivated SIV vaccine grown on human cells fails to protect against homologous SIV grown on simian cells.
Several groups have reported protection against experimental SIV infection in macaques immunized with a whole inactivated virus vaccine. The aim of the current study was to investigate whether five macaques vaccinated with whole inactivated SIV and previously shown to be protected against challenge with two divergent strains of SIV grown on human cells could resist challenge with a subsequent homologous SIV grown on macaque cells. We show here that this same vaccine did not protect when the challenge virus was grown on primary cells of monkey origin.
Putkonen
P
P
Department of Immunology, National Bacteriological Laboratory, Stockholm, Sweden.
Nilsson
C
C
Hild
K
K
Benthin
R
R
Cranage
M
M
Aubertin
A M
AM
Biberfeld
G
G
D016915:AIDS Vaccines / Q000302:isolation & purification; D000818:Animals; D002460:Cell Line; D004195:Disease Models, Animal; D015686:Gene Products, env / Q000276:immunology; D006801:Humans; D008252:Macaca fascicularis; D015682:Retroviridae Proteins, Oncogenic / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000254:growth & development / Q000276:immunology*; D013045:Species Specificity; D015164:Vaccines, Inactivated / Q000302:isolation & purification / Q000494:pharmacology; D014760:Viral Fusion Proteins; D014765:Viral Vaccines / Q000302:isolation & purification / Q000494:pharmacology*; D014776:Virus Cultivation / Q000379:methods
D016915:AIDS Vaccines; D015686:Gene Products, env; D015682:Retroviridae Proteins, Oncogenic; D015164:Vaccines, Inactivated; D014760:Viral Fusion Proteins; D014765:Viral Vaccines; C059580:transmembrane protein, Simian immunodeficiency virus