[Effect of 1 alpha-OH-D3 on the bone metabolism after high tibial osteotomy].
The effect of 1-hydroxycholecalciferol (1 alpha-OH-D3) on bone metabolism during osteotomized bone healing was investigated. The study based on 19 female patients with gonarthrosis who underwent the high tibial osteotomy. In 10 selected randomly from these patients 1 alpha-OH-D3 (1.0 micrograms/day) was administered before and after the surgery. After operation the changes in bone density (by MD-method) and biochemical parameters were followed. In the non-treated group the serum level of [Ca] x [P] product temporarily decreased at 3 days after surgery. Average bone density at two months after the surgery was 8.8% lower than the preoperative value. In contrast, 1 alpha-OH-D3 treated group showed significantly less decrease of serum [Ca] x [P] product at the third day than the control group and no significant decrease of bone density at two months after the operation. From these results, it was concluded that the 1 alpha-OH-D3 suppresses the decrease of serum Ca and P level and systemic osteopenia after osteotomy and may have an beneficial effect on fracture healing.
Yamashita
I
I
Department of Orthopedic Surgery, Asahikawa Rehabilitation Hospital, Hokkaido, Japan.
Miyatsu
M
M
Kamo
Y
Y
Atsuta
Y
Y
Onozawa
T
T
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000601:surgery; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007719:Knee Joint; D008875:Middle Aged; D010027:Osteotomy; D010758:Phosphorus / Q000097:blood; D013977:Tibia / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects
D006887:Hydroxycholecalciferols; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium; C008088:alfacalcidol