Problems with stopping rules in the trials of risky therapies: the case of warfarin to prevent stroke in atrial fibrillation.
Singer
D E
DE
General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114.
D001281:Atrial Fibrillation / Q000188:drug therapy*; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D036302:Therapeutic Human Experimentation; D014859:Warfarin / Q000627:therapeutic use*
D014859:Warfarin