title: Interval cancers and sensitivity in the screening centres of the UK trial of early detection of breast cancer.
abstract: The incidence rates of interval cancers following a negative breast screen in two screening centres which offered women aged 45-64 annual screening by mammography and/or clinical examination are examined. Sensitivity of screening is estimated by comparing the incidence rate of interval cancers with that expected in the absence of screening, and the results are compared with those from alternative methods of calculating sensitivity. The incidence rate of cancers diagnosed within 12 months of a negative screen by mammography plus clinical examination was reduced by 70% for women aged 45-54, and 84% for women aged 55+. There is no indication from this that sensitivity in the UK trial was substantially lower than in other studies which have achieved larger reductions in mortality.
authors.affiliation: Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, Surrey, U.K.
authors.forename: S M
authors.initials: SM
authors.lastname: Moss
authors.forename: D A
authors.initials: DA
authors.lastname: Coleman
authors.forename: R
authors.initials: R
authors.lastname: Ellman
authors.forename: J
authors.initials: J
authors.lastname: Chamberlain
authors.forename: A P
authors.initials: AP
authors.lastname: Forrest
authors.forename: A E
authors.initials: AE
authors.lastname: Kirkpatrick
authors.forename: B A
authors.initials: BA
authors.lastname: Thomas
authors.forename: J L
authors.initials: JL
authors.lastname: Price
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D008327:Mammography; D008875:Middle Aged; D010808:Physical Examination; D012680:Sensitivity and Specificity; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology