EEG changes with aging in adults with Down syndrome.
The EEGs of 40 subjects with Down syndrome (DS) aged 15 to 54 were investigated and compared with those of 42 mentally retarded subjects without DS (MR) and 47 healthy volunteers. The frequencies of the occipital alpha rhythms decreased with age in the DS subjects, and were significantly slower than the MR subjects over 35 years old. The slowing of alpha rhythm in the older DS subjects accompanied an increase of slow activity of 6-8 Hz, but did not relate to the deterioration of activities of daily life (ADL) as estimated by the GBS score. Twenty-one subjects with DS were examined by a CT scan as well, and showed no age-related morphometric changes.
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Department of Neuropsychiatry, Wakayama Medical College, Japan.
D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000513:Alpha Rhythm; D001479:Basal Ganglia / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002114:Calcinosis / Q000175:diagnosis / Q000503:physiopathology; D004314:Down Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009048:Motor Skills; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed