Inhibition of lipid peroxidation in rat brain by nifedipine and clorazepate after electrically induced seizures.
The effect of nifedipine and clorazepate on the concentration of lipid peroxides (LP) in rat brain, and the characteristics of electrically induced seizures were assessed. A significant increase in the concentration of brain LP after electroshock was found. Both nifedipine (1.00 mg/kg per os) and clorazepate (20 mg/kg intraperitoneally) decreased the levels of LP in the rat brain after electroshock. Nifedipine combined with clorazepate brought an inhibition of LP formation and an additive anticonvulsant activity.
Kułak
W
W
Department of Neurology, Medical Academy, Białystok, Poland.
Sobaniec
W
W
Sobaniec-Lotowska
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003009:Clorazepate Dipotassium / Q000494:pharmacology*; D004597:Electroshock; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000378:metabolism*
D003009:Clorazepate Dipotassium; D009543:Nifedipine