title: Management of advanced juvenile granulosa cell tumor of the ovary.
abstract: Juvenile granulosa cell tumor of the ovary occurs most frequently in young women and children. Ten percent of cases present during pregnancy. The majority of tumors are in FIGO Stage I and have a favorable prognosis. The prognosis of higher stage tumors, however, is generally less favorable. We report the long-term, disease-free survival of a patient with FIGO Stage III juvenile granulosa cell tumor of the ovary. We believe this to be the first report of a successful pregnancy following "MAC" chemotherapy for this particular malignancy.
authors.affiliation: Department of Obstetrics and Gynecology, Baystate Medical Center, Springfield, Massachusetts 01199.
authors.forename: J L
authors.initials: JL
authors.lastname: Powell
authors.forename: N A
authors.initials: NA
authors.lastname: Johnson
authors.forename: C L
authors.initials: CL
authors.lastname: Bailey
authors.forename: C N
authors.initials: CN
authors.lastname: Otis
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002699:Chlorambucil / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000628:therapy*
chemical_list: D002699:Chlorambucil; D003609:Dactinomycin; D008727:Methotrexate