title: Chromosomes in the genesis and progression of ependymomas.
abstract: Cytogenetic analysis was performed on cultures of primary ependymal tumors with different degrees of malignancy (I-IV) obtained from four patients, none of whom had received therapy before karyotypic evaluation. The most common abnormalities were monosomy 17 and 22 in four cases and losses of sex chromosomes in three cases. Structural rearrangements of chromosome 2 were a finding for all cases and involved loss of material at 2q32-34. Other structural chromosome abnormalities detected involved chromosomes 4, 6, 10, 11, 12, and X. We also reviewed data on 22 cases previously reported.
authors.affiliation: Departamento de Biologia Geral, CCB, Universidade Estadual de Londrina, Brazil.
authors.forename: S R
authors.initials: SR
authors.lastname: Rogatto
authors.forename: C
authors.initials: C
authors.lastname: Casartelli
authors.forename: C A
authors.initials: CA
authors.lastname: Rainho
authors.forename: J
authors.initials: J
authors.lastname: Barbieri-Neto
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D004806:Ependymoma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D009006:Monosomy; D012729:Sex Chromosome Aberrations