title: Eosinophilia-myalgia syndrome: a clinicopathological study of four patients.
abstract: Eosinophilia-myalgia syndrome is an idiopathic disorder characterized by myalgia, especially of the extremities and peripheral eosinophilia. It is found in some patients as a result of tryptophan ingestion. We examined four patients showing clinical features and muscle biopsy changes consistent with eosinophilia-myalgia syndrome. The results of conventional histology were compared with immunohistochemical studies using monoclonal antibodies to human T lymphocytes, macrophages, HLA-DR antigen. Our findings confirm the potential importance of lymphocytes and macrophages in this syndrome. In particular, new observations are presented concerning the immunoreactivity of HLA-DR antigen.
authors.affiliation: Laboratory of Neuropathology, University of Antwerp, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Villanova
authors.forename: L S
authors.initials: LS
authors.lastname: De Clerck
authors.forename: P
authors.initials: P
authors.lastname: Cras
authors.forename: C
authors.initials: C
authors.lastname: Ceuterick
authors.forename: E
authors.initials: E
authors.lastname: Van Marck
authors.forename: G C
authors.initials: GC
authors.lastname: Guazzi
authors.forename: J J
authors.initials: JJ
authors.lastname: Martin
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001706:Biopsy; D016603:Eosinophilia-Myalgia Syndrome / Q000473:pathology*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens