Identification of some marker chromosomes in acute leukemias by fluorescence in situ hybridization.
Four patients with acute leukemia are presented in whom conventional karyotypic analysis had revealed complex numerical and structural changes including unidentifiable (marker) chromosomes. It is demonstrated that the application of fluorescence in situ hybridization (FISH) may contribute to the identification of such anomalies.
Shi
G
G
Department of Oncology/Haematology, Medical University Clinic, Hamburg, Germany.
Weh
H J
HJ
Hossfeld
D K
DK
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000502:physiology; D002877:Chromosomes, Human / Q000502:physiology*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
D005819:Genetic Markers