title: Atherosclerosis in young white males: arterial collagen and cholesterol.
abstract: As part of a multicenter study on atherosclerosis, we examined defined segments of thoracic and abdominal aortas from 118 white males, age 15-34 years, who died from external causes. One half of each aorta specimen was graded for lesions. Intima-media preparations were assayed for collagen and cholesterol in two standardized regions (dorsal and ventral) derived from the alternate half of each segment. Even though the mean extent of intimal surface involvement with raised lesions remained minimal (0-6%), the data revealed a remarkable transition in vessel wall chemistry over this time span. For example, the amount of collagen per unit surface area increases with age in all vessel segments except the ventral domain of the thoracic aorta. The amount of collagen as a percent of total vessel protein rises with age only in the ventral and dorsal regions of the abdominal aorta. Free and esterified cholesterol levels per unit surface area increase with age in all vessel segments. There is a significant correlation between collagen and esterified cholesterol per unit surface area in all vessel regions with the exception of the abdominal ventral segment. In the latter segment increases in collagen per unit surface area occur without a corresponding increase in cholesterol level suggesting that connective tissue proliferation may actually precede lipid deposition in the genesis of atherosclerosis. Esterified cholesterol is present at higher levels in the dorsal domains of the thoracic and abdominal aortas than in the ventral domains. These findings provide chemical data confirming that the dorsal domains is the most lesion-prone region of these vessel segments.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Biochemistry, University of Alabama, Birmingham.
authors.forename: E J
authors.initials: EJ
authors.lastname: Miller
authors.forename: G T
authors.initials: GT
authors.lastname: Malcom
authors.forename: C A
authors.initials: CA
authors.lastname: McMahan
authors.forename: J P
authors.initials: JP
authors.lastname: Strong
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001012:Aorta, Abdominal / Q000737:chemistry / Q000473:pathology*; D001013:Aorta, Thoracic / Q000737:chemistry / Q000473:pathology*; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology*; D001344:Autopsy; D002784:Cholesterol / Q000032:analysis*; D002788:Cholesterol Esters / Q000032:analysis; D003094:Collagen / Q000032:analysis*; D006801:Humans; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000737:chemistry / Q000473:pathology; D044465:White People
chemical_list: D002788:Cholesterol Esters; D003094:Collagen; D002784:Cholesterol