Prevalence of neural tube defects in South Australia, 1966-91: effectiveness and impact of prenatal diagnosis.
OBJECTIVE
To determine trends in total prevalence of neural tube defects in South Australia during 1966-91, the impact of prenatal diagnosis on birth prevalence, and the effectiveness of prenatal screening for neural tube defects in 1986-91.


METHODS
All births and terminations of pregnancy affected by neural tube defects and information on prenatal screening were ascertained from multiple sources including the South Australian perinatal and abortion statistics collections, birth defects register, and state maternal serum alpha fetoprotein screening programme.


METHODS
Southern Australia.


METHODS
All 1058 births and terminations of pregnancy affected by neural tube defects in 1966-91.


METHODS
Total prevalence and birth prevalence of individual and all neural tube defects. The proportion of screened cases detected prenatally.


RESULTS
Total prevalence of neural tube defects during 1966-91 was 2.01/1000 births with no upward or downward trend. However, birth prevalence fell significantly (by 5.1% a year), with an 84% reduction from 2.29/1000 births in 1966 to 0.35/1000 in 1991 (relative risk = 0.16, 95% confidence interval 0.07 to 0.34). The fall was 96% for anencephaly and 82% for spina bifida. 85% of defects, both open and closed, were detected before 28 weeks' gestation in women screened by serum alpha fetoprotein or mid-trimester ultrasonography, or both, in 1986-91 (99.0% for anencephaly and 75.7% for spina bifida).


CONCLUSIONS
While the total prevalence of neural tube defects in South Australia remained stable, prenatal diagnosis and termination of pregnancy resulted in an 84% fall in birth prevalence during 1966-91. Screening detected over four fifths of cases in 1986-91.
Chan
A
A
Pregnancy Outcome Unit, South Australian Health Commission, Adelaide.
Robertson
E F
EF
Haan
E A
EA
Keane
R J
RJ
Ranieri
E
E
Carney
A
A
D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000517:prevention & control; D011247:Pregnancy; D011296:Prenatal Diagnosis; D015995:Prevalence; D012307:Risk Factors; D013021:South Australia / Q000453:epidemiology