[Comparison of the effectiveness of oil and water solutions of alpha-tocopherol as radiation protection agent].
The change in alpha-tocopherol content (as an index of the antioxidative organism system mobilization) in the brain, liver, muscles and heart of rats prior to and after total gamma-irradiation with lethal dose has been studied. Prior to the irradiation alpha-tocopheryl-acetate (oil solution), alpha-tocopheryl-phosphate dipotassium salt (water solution), gammaphos (prepared WR 2721, water solution) were introduced into rats. It is shown that water-soluble form of vitamin E is more effective than gammaphos and much more efficient than oil form of alpha-tocopherol.
Paranich
A V
AV
Oleksieiev
S M
SM
Tarabrin
M B
MB
Godonu
Zh
Zh
Savchenko
G V
GV
Traore
M
M
D004999:Amifostine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000528:radiation effects; D006321:Heart / Q000187:drug effects / Q000528:radiation effects; D008099:Liver / Q000187:drug effects / Q000528:radiation effects; D009132:Muscles / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014916:Whole-Body Irradiation; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D011837:Radiation-Protective Agents; D012996:Solutions; D014810:Vitamin E; C012552:alpha-tocopherol phosphate; D024502:alpha-Tocopherol; D004999:Amifostine; D024505:Tocopherols