title: The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin.
abstract: The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the gamma 1 and gamma 2 components, respectively. The HlgB protein (gamma 2) has 27% residue identity with S. aureus alpha-toxin. Surprisingly, hlgB and hlgC are 98.5 and 99.1% identical to the lukF and lukS genes, respectively, encoding the F and S components of the Panton-Valentine leukocidin.
authors.affiliation: Department of Medical and Physiological Chemistry, University of Lund, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Cooney
authors.forename: Z
authors.initials: Z
authors.lastname: Kienle
authors.forename: T J
authors.initials: TJ
authors.lastname: Foster
authors.forename: P W
authors.initials: PW
authors.lastname: O'Toole
mesh_terms: D000595:Amino Acid Sequence; D001427:Bacterial Toxins / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D005798:Genes, Bacterial; D006460:Hemolysin Proteins / Q000235:genetics*; D007956:Leukocidins / Q000235:genetics*; D008969:Molecular Sequence Data; D013211:Staphylococcus aureus / Q000235:genetics*
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D007956:Leukocidins