title: Anterior mediastinal mass in a patient susceptible to malignant hyperthermia.
abstract: We report a malignant hyperthermia-susceptible patient who required investigation for a large, symptomatic anterior mediastinal mass. Multiple attempts at tissue diagnosis under local anaesthesia were unsuccessful. Following awake fibreoptic tracheal intubation, general anaesthesia was administered using ketamine, midazolam, and nitrous oxide, maintaining spontaneous ventilation. Prophylactic dantrolene was not used, to avoid potential muscle weakness and respiratory compromise. Diagnostic mediastinotomy was performed without incident. We conclude that ketamine anaesthesia is appropriate for patients with anterior mediastinal masses, and is considered safe in malignant hyperthermia-susceptible patients.
authors.affiliation: Department of Anaesthesia, Ottawa Civic Hospital, Ontario.
authors.forename: G C
authors.initials: GC
authors.lastname: Allen
authors.forename: L J
authors.initials: LJ
authors.lastname: Byford
authors.forename: F M
authors.initials: FM
authors.lastname: Shamji
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000772:Anesthesia, Local; D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D007442:Intubation, Intratracheal; D007649:Ketamine; D008012:Lidocaine; D008305:Malignant Hyperthermia / Q000150:complications* / Q000503:physiopathology; D008479:Mediastinal Neoplasms / Q000150:complications*; D008874:Midazolam; D009609:Nitrous Oxide
chemical_list: D007649:Ketamine; D008012:Lidocaine; D009609:Nitrous Oxide; D008874:Midazolam