[Drug-induced syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Review of literature].
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is caused by an incapacity of plasmatic hypotonia to inhibit antidiuretic hormone (ADH) secretion. This phenomenon leads to a water retention and an expanded extracellular fluid volume, and secondary to a dilution of plasmatic sodium and also to a renal loss of sodium. The SIADH is a relatively rare syndrome, which may occur in various circumstances: central nervous system diseases, cancers, infections... Sometimes, it may be observed as a drug-related side effect: carbamazepine, chlorpropamide, antidepressors, anticancer drugs are particularly involved.
Verstraeten
L
L
Service de Biochimie Médicale, Cliniques Universitaires St-Luc, Bruxelles, Belgique.
Dewier
B
B
Montjoie
C
C
Hassoun
A
A
D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*