Acquired unbalanced hemoglobin chain synthesis during HIV infection.
Few abnormalities have been described up to know in the red cell lineage of HIV patients except for a slight anemia. To better interpret this, a hemoglobin study was performed in a group of 71 HIV infected patients. By contrast to patients at stage II or III, those at stage IV of the disease had moderate elevation of HbA2 level. A second group of ten patients being at stage IV of HIV infection and having moderate increase in HbA2 level were found to have beta thalassemia-like unbalanced biosynthetic globin ratio, unlike a control group with chronic inflammation condition. The observed abnormality may be a feature reflecting the peculiar disordered erythropoiesis seen in the late stage of this disease.
Galactéros
F
F
INSERM U91 et Service de Biochimie, Hôpital Henri-Mondor, Créteil, France.
Amaudric
F
F
Préhu
C
C
Feingold
N
N
Doucet-Populaire
F
F
Sobel
A
A
Rosa
J
J
D000328:Adult; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000473:pathology; D006443:Hemoglobin A2 / Q000032:analysis; D006454:Hemoglobins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017086:beta-Thalassemia / Q000097:blood / Q000209:etiology
D006454:Hemoglobins; D006443:Hemoglobin A2