Lithium induces changes in the plasma membrane protein pattern of early amphibian embryos.
The plasma membrane protein pattern of Rana ridibunda embryos subjected to lithium (Li) treatment at various stages of development was examined by two-dimensional gel electrophoresis. Differences were observed at the neurula stage not only as compared to controls but among lithium-treated embryos as well. Of particular interest was the presence of proteins, specific for the gastrula stage, in lithium-treated embryos. The results are discussed in relation to the well-known effect of lithium on amphibian morphogenesis.
Lazou
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Department of Zoology, School of Sciences, University of Thessaloniki, Greece.
Beis
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D000818:Animals; D002970:Cleavage Stage, Ovum / Q000187:drug effects; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D008094:Lithium / Q000633:toxicity*; D008565:Membrane Proteins / Q000187:drug effects*; D009436:Neural Tube Defects / Q000139:chemically induced*; D011895:Rana ridibunda
D008565:Membrane Proteins; D008094:Lithium