Systemic osteoclast activation by localized pressure.
It has been demonstrated that positive air pressure applied to the bulla of the Mongolian gerbil results in significant osteoclastic activation and bone resorption. In this study, continuous positive air pressure of 15 mm Hg was applied to the right bulla for 1 week. A significant increase in osteoclast number and surface were noted in the contralateral, unpressurized bulla as well as in a distant site, the upper extremity (radius). Possible mechanisms are discussed by which a local stimulus (pressure) may cause distant osteoclast activation.
Wolfman
D E
DE
Department of Otolaryngology, Kaiser Permanente Medical Center-South Sacramento, CA.
Tinling
S P
SP
D000399:Air Pressure; D000818:Animals; D001706:Biopsy; D001830:Body Surface Area; D001862:Bone Resorption / Q000503:physiopathology*; D002781:Cholesteatoma / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000033:anatomy & histology / Q000502:physiology*; D005069:Evaluation Studies as Topic; D005849:Gerbillinae; D008297:Male; D010010:Osteoclasts / Q000502:physiology*; D011453:Prostaglandins / Q000502:physiology
D016207:Cytokines; D011453:Prostaglandins