In vitro activity of vancomycin and teicoplanin against Staphylococcus aureus and Staphylococcus epidermidis colonizing catheters.
In a quantitative in vitro model the activity of vancomycin and teicoplanin in two concentrations (4 x MBC and 1 mg/l) against Staphylococcus aureus and a slime-producing Staphylococcus epidermidis strain colonizing the internal surface of polyurethane and silicone catheters was studied. In comparison with vancomycin, teicoplanin achieved a significantly greater reduction (p < 0.05) in the counts of Staphylococcus aureus and Staphylococcus epidermidis adhering to both polyurethane and silicone catheters.
Kropec
A
A
Institute for Environmental Medicine and Hospital Epidemiology, University Hospital of Freiburg, Germany.
Huebner
J
J
Wursthorn
M
M
Daschner
F D
FD
D002405:Catheterization, Central Venous / Q000145:classification; D015169:Colony Count, Microbial; D008954:Models, Biological; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development*; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development*; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
D017334:Teicoplanin; D014640:Vancomycin