Jejunum is preferable for construction of a Bianchi bowel-lengthening procedure in swine short bowel.
This study compared the efficacy of a Bianchi bowel-lengthening procedure performed in residual ileum and jejunum of a 75% short bowel model. Eighteen female piglets underwent a 75% mid small bowel resection. After a 6-week period, animal weights were similar and pigs were randomly assigned to one of three treatment groups: (1) a control group receiving no further therapy; (2) a group receiving a Bianchi procedure in the residual jejunal segment; and (3) a group receiving a Bianchi procedure in the residual ileal segment. All were followed for a further 12 weeks. Jejunal Bianchi-treated short bowel animals demonstrated a greater final weight gain (78.8 +/- 4.9 kg) compared with nontreated short bowel (63.0 +/- 6.6 kg) and ileal Bianchi-treated short bowel groups (69.3 +/- 6.9 kg) in addition to a larger jejunal diameter. The increased weight gain in the jejunal Bianchi-treated group was not a consequence of initial bowel length, food intake, changes in bowel length, digestibility of nitrogen or fat, or nutritional status. Furthermore, kinetic constants for D-glucose absorption following 18 weeks of short-bowel syndrome demonstrated a lowered glucose maximal transport rate (Vmax) in animals with nontreated short bowel compared with sham-operated controls. Additionally, jejunal and ileal glucose Vmax was further lowered in the presence of a Bianchi procedure. We conclude that: (1) during short-bowel syndrome, body weight gain was significantly higher in animals when the Bianchi procedure was performed in jejunum; (2) the short-bowel syndrome decreased intestinal glucose absorption; and (3) the Bianchi procedure itself further impaired glucose transport.
Buie
W D
WD
Faculty of Medicine, University of Alberta, Edmonton, Canada.
Thurston
O G
OG
vanAerde
J E
JE
Aherne
F X
FX
Thomson
A B
AB
Fedorak
R N
RN
D000818:Animals; D004435:Eating; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000493:pharmacokinetics; D007082:Ileum / Q000033:anatomy & histology / Q000378:metabolism / Q000601:surgery*; D007408:Intestinal Absorption; D007583:Jejunum / Q000033:anatomy & histology / Q000378:metabolism / Q000601:surgery*; D011897:Random Allocation; D012778:Short Bowel Syndrome / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D013514:Surgical Procedures, Operative / Q000379:methods / Q000401:mortality; D013552:Swine; D015430:Weight Gain
D005947:Glucose