[Serum superoxide dismutase (SOD) activity in patients with renal disease by a spintrap method using electron spin resonance (ESR)].
Superoxide dismutase (SOD) activity in serum samples of patients with chronic glomerulonephritis (CGN) and chronic renal failure (CRF) was measured by a spin trap method using electron spin resonance (ESR). Twenty-three patients with CGN, 10 patients with CRF and 10 healthy adults were examined. Among 23 patients with CGN, there were 12 patients with IgA nephropathy and one patient with membranous nephropathy diagnosed by immunofluorescence of renal biopsy specimens. Other CGN patients were diagnosed by its clinical criteria. The serum activity of SOD in patients with CGN or CRF was significantly higher than those in healthy adults (p < 0.05). The serum SOD activity in patients with CRF was also higher than those in patients with CGN (p < 0.05). Marked high levels of serum SOD activity were observed histologically in the advanced stage of IgA nephropathy. These results suggest an increase in serum SOD activity may reflect renal injuries in patients with CGN and CRF.
Yokoyama
K
K
Department Medicine, Juntendo University, Tokyo, Japan.
Tomino
Y
Y
Yaguchi
Y
Y
Koide
H
H
Ohmori
D
D
Yamakura
F
F
D002908:Chronic Disease; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005921:Glomerulonephritis / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase