Event-related potentials, reaction time, and cognitive state in patients with Parkinson's disease.
ERPs, RT, and cognitive state in 53 patients with PD were studied. The peak latency of P300 and the RT in PD patients were significantly prolonged in the advanced stage of illness. The cognitive state in PD patients was characterized by impairment of attention, recent memory, and constructional ability in categories of the Folstein Mini-Mental State Examination. The significant association between neurophysiological and neuropsychological measurements suggests that these measurements reflect a disrupted aspect of cognitive function in PD patients.
Hayashi
R
R
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
Hanyu
N
N
Shindo
M
M
Tamaru
F
F
Yanagisawa
N
N
D000368:Aged; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology; D003704:Dementia / Q000175:diagnosis / Q000503:physiopathology*; D004569:Electroencephalography / Q000295:instrumentation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation