Capillary electrophoresis quantitation of l-L-folinic acid in the presence of its inactive d-L-form.
The diastereomers d-L and l-L-folinic acid were separated by capillary electrophoresis, using heptakis (2,3-di-O-methyl)-beta-cyclodextrin as a chiral active component in the background electrolyte. The method proved suitable for the quantitation of these compounds in one commercial pharmaceutical preparation.
Cellai
L
L
Istituto di Strutturistica Chimica, CNR, Roma Italy.
Desiderio
C
C
Filippetti
R
R
Fanali
S
S
D002197:Capillary Action; D003505:Cyclodextrins; D004586:Electrophoresis / Q000379:methods*; D002955:Leucovorin / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; C031215:betadex; D002955:Leucovorin