In utero acute graft-versus-host disease in a neonate with severe combined immunodeficiency.
We describe a male neonate with severe combined immunodeficiency who at birth had acute graft-versus-host disease (GVHD) as a result of maternal-fetal transfusion during pregnancy. Several clinical signs helped establish this diagnosis. Findings of a skin biopsy specimen confirmed the diagnosis of acute GVHD. Immunologic evaluation disclosed an absence of T and B lymphocytes. Acute GVHD in severe combined immunodeficiency most often occurs during the first weeks of life; intrauterine occurrence is unusual.
Alain
G
G
Université de Montréal, Québec, Canada.
Carrier
C
C
Beaumier
L
L
Bernard
J
J
Lemay
M
M
Lavoie
A
A
D001706:Biopsy; D003873:Dermatitis, Exfoliative / Q000209:etiology; D005260:Female; D005331:Fetomaternal Transfusion / Q000150:complications*; D006086:Graft vs Host Disease / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D016511:Severe Combined Immunodeficiency / Q000150:complications / Q000151:congenital*; D012867:Skin / Q000473:pathology