CSF homovanillic acid in schizotypal personality disorder.
CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.
Siever
L J
LJ
Psychiatry Service, VA Medical Center, Bronx, NY 10468.
Amin
F
F
Coccaro
E F
EF
Trestman
R
R
Silverman
J
J
Horvath
T B
TB
Mahon
T R
TR
Knott
P
P
Altstiel
L
L
Davidson
M
M
D000328:Adult; D003937:Diagnosis, Differential; D004298:Dopamine / Q000502:physiology; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012569:Schizotypal Personality Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000503:physiopathology
D004298:Dopamine; D006719:Homovanillic Acid