Neonatal rat liver contains low concentrations of Cu-Zn superoxide dismutase protein and mRNA.
Copper (Cu) distribution among organs and among individual proteins can differ sharply between neonates and adults. The present study found low mRNA and protein levels for neonate rat liver cytosolic Cu-zinc (Zn) superoxide dismutase (SOD), normally among the largest single copper pools in adult rats. Thus, regulation of Cu-Zn SOD mRNA levels contribute to life stage differences in copper distribution.
Yang
F L
FL
Human Nutrition, Ohio State University, Columbus 43210.
David
E A
EA
DiSilvestro
R A
RA
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D003300:Copper / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000032:analysis*
D012333:RNA, Messenger; D003300:Copper; D013482:Superoxide Dismutase