Some biochemical aspects of the protective effect of strontium chloride on gamma-irradiated rats.
The effect of treatment with SrCl2 (10 mg 100 g-1) on rats 15 min prior to whole body gamma-irradiation (7.5 Gy) was studied. The hazardous effects of irradiation were greatly corrected in the treated group. The hyperglycemic effect and liver glycogen accumulation in the untreated group decreased to normal level. The enzymatic activities of serum alkaline phosphatase, alanine and aspartate aminotransferases, and lactate dehydrogenase were greatly affected, showing insignificant changes in the treated group of animals. Life span calculated on 50% survival was also significantly elongated by 36.3%. These results show the potentiality of SrCl2 as a radioprotective agent. A proposed mechanism is discussed.
Fahim
F A
FA
Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Roshdy
H M
HM
Yousri
R M
RM
Abady
M I
MI
D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008099:Liver / Q000187:drug effects / Q000528:radiation effects; D008136:Longevity / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D013324:Strontium / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; C025700:strontium chloride; D013324:Strontium