title: Arterial ketone body ratio as a predictor of donor liver viability in human liver transplantation.
abstract: The viability of the donor liver was assessed with regard to early postoperative survival in human liver transplantations from 40 brain-dead donors at Hannover Medical College and 13 living donors at Kyoto University by measuring the arterial ketone body ratio (AKBR). Of 40 grafts harvested from brain-dead patients in Hannover, 35 survived the first week after operation, but 5 developed initial nonfunction of the transplanted graft within the first week. The mean AKBR values were 1.11 +/- 0.11 for grafts that survived and 0.44 +/- 0.10 for grafts that failed (P < 0.01). The AKBR values of the 5 initially nonfunctioning cases were all below 0.7. Of 13 grafts harvested from the living donors in Kyoto, all survived the first week. The AKBR values of the donors were all above 1.0, with a mean value of 1.87 +/- 0.23. Among all 53 cases, the survival rate of the grafts with AKBR above 0.7 was significantly higher than that of the grafts with AKBR below 0.7 (100% vs. 62%, P < 0.01). No other donor parameters, including age, dose of dopamine administered, and clinical laboratory findings, were significantly related to differences in graft survival rates. AKBR is a useful index for the evaluation of donor liver viability. Grafts used from donors with AKBR of less than 0.7 have a significantly increased risk of early nonfunction. Grafts from donors with AKBR of greater than 1.0 have, in our experience, always been viable after transplantation.
authors.affiliation: Second Department of Surgery, Kyoto University Faculty of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: M
authors.initials: M
authors.lastname: Washida
authors.forename: D
authors.initials: D
authors.lastname: Manaka
authors.forename: G
authors.initials: G
authors.lastname: Gubernatis
authors.forename: B
authors.initials: B
authors.lastname: Ringe
authors.forename: N
authors.initials: N
authors.lastname: Ozaki
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Ollerich
authors.forename: K
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000328:Adult; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000502:physiology*; D016031:Liver Transplantation / Q000502:physiology*; D009926:Organ Preservation; D012189:Retrospective Studies
chemical_list: D007657:Ketone Bodies