title: Exclusion mapping in familial non-specific dementia.
abstract: We present genetic linkage data in a large family in which non-specific dementia is inherited as an autosomal dominant trait. We have analyzed 45 highly polymorphic microsatellite sequences and excluded a quarter of the genome as the site of the pathogenic mutation in this family.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: S
authors.initials: S
authors.lastname: Gydesen
authors.forename: S A
authors.initials: SA
authors.lastname: Sorensen
authors.forename: A
authors.initials: A
authors.lastname: Brun
authors.forename: K
authors.initials: K
authors.lastname: Duff
authors.forename: H
authors.initials: H
authors.lastname: Houlden
authors.forename: L
authors.initials: L
authors.lastname: Fidani
authors.forename: S
authors.initials: S
authors.lastname: Kullkarni
authors.forename: J
authors.initials: J
authors.lastname: Cummings
authors.forename: A
authors.initials: A
authors.lastname: Goate
mesh_terms: D000328:Adult; D000368:Aged; D004276:DNA, Satellite / Q000032:analysis / Q000097:blood; D003704:Dementia / Q000235:genetics* / Q000473:pathology; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012984:Software
chemical_list: D004276:DNA, Satellite