Parental age, genetic mutation, and cerebral palsy.
Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
Fletcher
N A
NA
Department of Neurological Sciences, St Bartholomew's Hospital, London.
Foley
J
J
D000293:Adolescent; D000328:Adult; D001264:Athetosis; D001722:Birth Order; D002547:Cerebral Palsy / Q000145:classification / Q000235:genetics* / Q000473:pathology; D004421:Dystonia; D005799:Genes, Dominant; D006429:Hemiplegia; D006801:Humans; D007231:Infant, Newborn; D008423:Maternal Age; D008875:Middle Aged; D009154:Mutation; D010243:Paralysis; D010331:Paternal Age; D011782:Quadriplegia