Biochemical markers for detecting bone metastases in patients with breast cancer.
A study was carried out to assess the best use of biochemical bone markers to exclude metastases in patients with breast cancer. Urinary galactosyl-hydroxylysine and serum alkaline phosphatase were used to monitor bone resorption and deposition, respectively. Hydroxyproline was also measured. In a selected population of patients, possibly affected by metastases on the basis of scintigraphic examination, which is highly sensitive but poorly specific, we assessed the efficiency of the markers by a double statistical analysis. In this group, the only marker able to predict metastases was galactosyl-hydroxylysine.
Moro
L
L
Dipartimento di Biochimica, Universita degli Studi di Trieste, Italy.
Gazzarrini
C
C
Crivellari
D
D
Galligioni
E
E
Talamini
R
R
de Bernard
B
B
D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000556:secondary*; D001862:Bone Resorption; D001842:Bone and Bones / Q000503:physiopathology*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives / Q000652:urine; D006909:Hydroxyproline / Q000652:urine
D014408:Biomarkers, Tumor; D006901:Hydroxylysine; C007817:galactosylhydroxylysine; D000469:Alkaline Phosphatase; D006909:Hydroxyproline