title: Changes in serum thyroid hormone levels and urinary ketone body excretion caused by a low selenium diet or silver loading in rats.
abstract: Biochemical indices of selenium (Se) deficiency (tissue Se content and glutathione peroxidase activity, serum thyroid hormone level, and urinary ketone bodies during fasting) were measured in rats fed a low-Se diet or rats loaded with silver (Ag). One group of male weanling Wistar rats was fed a casein-based low-Se basal diet (Se content, 0.027 mg/kg). Other groups were fed the basal diet supplemented with sodium selenite (0.2 mg/kg of Se), or silver acetate (250 mg/kg of Ag), or both for 6 weeks. Without silver loading, hepatic and blood Se contents and GSH-Px activities were much lower in the rats fed the basal diet than in the rats fed the selenite-supplemented diet. The Ag loading decreased the Se contents and GSH-Px activities irrespective of dietary Se level. There were significantly higher serum thyroxine (T4) concentrations in rats fed the low-Se diet and in Ag-loaded rats than in rats fed the selenite-supplemented diet without added Ag. Differences in serum 3'-, 5, 3-triiodothyronine (T3) concentration were not significant among the 4 groups. Urinary ketone body excretion was abnormally high in rats fed the basal low-Se diet, but Ag-loading decreased the ketone body excretion; ketone body metabolism in the Ag-induced low-Se state was different from that in the diet-induced low-Se state.
authors.affiliation: Department of Public Health, Kansai Medical University, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D007657:Ketone Bodies / Q000652:urine*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000097:blood / Q000172:deficiency*; D012834:Silver / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D007657:Ketone Bodies; D014284:Triiodothyronine; D012834:Silver; D005979:Glutathione Peroxidase; D012643:Selenium; D013974:Thyroxine