Assessment of left ventricular diastolic function in dilated cardiomyopathy with cine magnetic resonance imaging: effect of an angiotensin converting enzyme inhibitor, benazepril.
The effects of angiotensin converting-enzyme inhibitor, benazepril, on diastolic function in patients with dilated cardiomyopathy, with (n = 4) or without (n = 11) mitral regurgitation, were examined with the time-volume curve of the left ventricle derived from cine magnetic resonance images. Peak filling rate/end-systolic volume and ejection fraction were increased in the group without regurgitation (p < 0.01) but not in the group with regurgitation after treatment. There was a strong correlation between peak filling rate/end-systolic volume and ejection fraction (r = 0.89) and between the change in peak filling rate/end-systolic volume and that in ejection fraction after treatment (r = 0.74) in the group without regurgitation. These findings suggest that in some patients with dilated cardiomyopathy benazepril has favorable effects on diastolic function, which seem to be related to improvement in systolic function. This drug may not be as beneficial in patients with dilated cardiomyopathy complicated by mitral regurgitation.
Fujita
N
N
Department of Radiology, University of California, San Francisco 94143-0628.
Hartiala
J
J
O'Sullivan
M
M
Steiman
D
D
Chatterjee
K
K
Parmley
W W
WW
Higgins
C B
CB
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001552:Benzazepines / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D003971:Diastole / Q000187:drug effects* / Q000502:physiology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D009040:Motion Pictures / Q000295:instrumentation; D015588:Observer Variation; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; C044946:benazepril