Birdshot chorioretinopathy and Lyme borreliosis.
Two patients in whom ocular Lyme disease was suspected and who had antibodies to Borrelia burgdorferi developed birdshot chorioretinopathy and carried the HLA-A29 antigen. In a series of 11 patients with birdshot chorioretinopathy who carried the HLA-A29 antigen, three patients had antibodies against B. burgdorferi as determined by either immunofluorescence assay, enzyme-linked immunosorbent assay, Western blot analysis, or a combination of these tests. Further studies will be necessary to evaluate whether this is a false-positive reaction or whether B. burgdorferi has a causative role in the pathogenesis of birdshot chorioretinopathy.
Suttorp-Schulten
M S
MS
Netherlands Ophthalmic Research Institute, Amsterdam.
Luyendijk
L
L
van Dam
A P
AP
de Keizer
R J
RJ
Baarsma
G S
GS
Bos
P J
PJ
Rothova
A
A
D015153:Blotting, Western; D015748:Borrelia burgdorferi Group / Q000302:isolation & purification; D002825:Chorioretinitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D005451:Fluorescein Angiography; D005455:Fluorescent Antibody Technique; D015234:HLA-A Antigens / Q000032:analysis; D006801:Humans; D008193:Lyme Disease / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D011859:Radiography; D014792:Visual Acuity
D015234:HLA-A Antigens; C035524:HLA-A29 antigen