Hypertension and dyslipidemia in patients with insulinoma.
Hyperinsulinemia is alleged to contribute to the pathogenesis of hypertension and dyslipidemia (hypertriglyceridemia) in the setting of insulin resistance. To assess the association among hyperinsulinemia, hypertension, and hypertriglyceridemia in the absence of insulin resistance, we determined their prevalence in a large cohort of patients with insulinoma (N = 250). In this retrospective case-control study, patients with insulinoma were matched by age, gender, race, and year of operation with 217 control patients admitted to the hospital for elective cholecystectomy. Mean preoperative blood pressure measurements were compared between study patients and control patients. In addition, age-, gender-, and race-specific percentiles of blood pressure were compared with data from the National Health and Nutrition Examination Survey I, and those of triglycerides (N = 65) and cholesterol (N = 70) were compared with Mayo Clinic normal reference data. The study group consisted of 105 men and 145 women; the median age was 41 years (range, 8 to 82). The median duration of symptoms before operation was 1.9 years (range, 0.05 to 40 years). After adjustment for body mass index, no statistically significant differences in systolic and diastolic blood pressure were noted between patients with insulinoma and matched control patients (131 +/- 19 versus 128 +/- 18 mm Hg and 81 +/- 11 versus 79 +/- 9 mm Hg, respectively). No relationship was observed between duration of hyperinsulinemia (as long as 40 years) and blood pressure. The age- and gender-specific percentiles of systolic and diastolic blood pressure of the patients with insulinoma did not differ from the age- and gender-specific percentiles for the general white population.(ABSTRACT TRUNCATED AT 250 WORDS)
O'Brien
T
T
Division of Endocrinology/Metabolism, Mayo Clinic, Rochester, MN 55905.
Young
W F
WF
Palumbo
P J
PJ
O'Brien
P C
PC
Service
F J
FJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D005260:Female; D006770:Hospitals, Group Practice; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications*; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D015228:Hypertriglyceridemia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D007340:Insulinoma / Q000150:complications* / Q000601:surgery; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000601:surgery; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides