A biomarker for the assessment of niacin nutriture as a potential preventive factor in carcinogenesis.
The study of protective cellular responses to DNA damage has led to the working hypothesis that optimal niacin nutriture is a preventive factor in cancer. Described here is the development of a biomarker for determining niacin status termed Niacin Number. The combination of this biomarker with diet and cancer epidemiology will allow evaluation of the possible role of this nutrient in cancer risk.
Jacobson
E L
EL
Texas College of Osteopathic Medicine, University of North Texas Fort Worth.
Jacobson
M K
MK
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D001773:Blood Cells / Q000737:chemistry; D004249:DNA Damage / Q000502:physiology; D004260:DNA Repair / Q000502:physiology; D006801:Humans; D009243:NAD / Q000097:blood; D009249:NADP / Q000097:blood; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D009525:Niacin / Q000097:blood*; D009752:Nutritional Status; D011108:Polymers
D015415:Biomarkers; D011108:Polymers; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D009525:Niacin; D009249:NADP