[Preparation of the first peroral antibiotic, Anginol-tablet].
In 1892-1896 Ivan Honl and Jaroslav Bukovský successfully tested pyocyaneoprotein (pyocynase), later used as the pharmaceutical preparation Tonsilan, in the therapy of crural ulcers and other bacterial diseases. In 1911 Honl prepared pyocyaneoprotein as the first antibiotic in the form of tablets called Anginol-tablets. Anginol was used in the Czech Lands in infectious diseases of the pharynx and larynx, particularly in tonsillitis, until the end of the Second World War. The present paper reports the procedure of compounding Anginol-tablets and their composition.
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D000900:Anti-Bacterial Agents / Q000266:history* / Q000627:therapeutic use; D001426:Bacterial Proteins; D003604:Czechoslovakia; D049673:History, 20th Century; D013607:Tablets
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D013607:Tablets; C083459:pyocynase, Pseudomonas aeruginosa