title: Metabolic heterogeneity associated with high plasma triglyceride or low HDL cholesterol levels in men.
abstract: To further understand the factors involved in the regulation of high plasma triglyceride (TG) or low plasma high density lipoprotein cholesterol (HDL-C) levels, three groups of male subjects (normal TG with low HDL-C levels, high TG with normal HDL-C levels, and high TG with low HDL-C levels) were compared with a sample of normolipemic men with normal TG and HDL-C plasma levels. Mean age was 34 years (range, 20-42 years), and none of the subjects had plasma TG levels > 4.0 mmol/l or familial hypercholesterolemia. Both groups of subjects with high TG levels had a higher body mass index, waist circumference, waist-to-hip circumferences ratio, and a higher ratio of abdominal to femoral adipose tissue areas as measured by computed tomography when compared with normolipemic control subjects. However, during an oral glucose tolerance test only high TG-low HDL-C men had fasting hyperinsulinemia and higher plasma insulin levels compared with normolipemic subjects. In addition, the high TG-low HDL-C group showed reduced HDL apoprotein (apo) A-I levels and a low HDL2-C/HDL3-C ratio. These changes were observed along with a nonsignificant trend for a lower plasma postheparin lipoprotein lipase activity. However, among subjects with high TG and normal HDL-C levels, no evidence of insulin resistance or of a reduction in postheparin lipoprotein lipase activity was observed, suggesting that the high plasma TG levels could be attributed to an increased production of apo B-containing lipoproteins, as high plasma apo B and low density lipoprotein (LDL)-apo B levels were observed in this group.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Lipid Research Center, Laval University Medical Research Center, Québec, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Lamarche
authors.forename: J P
authors.initials: JP
authors.lastname: Després
authors.forename: M C
authors.initials: MC
authors.lastname: Pouliot
authors.forename: D
authors.initials: D
authors.lastname: Prud'homme
authors.forename: S
authors.initials: S
authors.lastname: Moorjani
authors.forename: P J
authors.initials: PJ
authors.lastname: Lupien
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
authors.forename: A
authors.initials: A
authors.lastname: Tremblay
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000032:analysis / Q000097:blood*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008079:Lipoproteins, VLDL / Q000032:analysis; D008297:Male; D012016:Reference Values; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D006493:Heparin; D008071:Lipoprotein Lipase