Effect of CCK-8 on audiogenic epileptic seizure in P77PMC rats.
P77PMC rat is a breed of rat with congenital audiogenic seizure(AS). AS attacks were suppressed by cholecystokinin octapeptide (CCK-8) injected intraperitoneally (i.p.) at a dose of 50 micrograms/kg, but not at 25 micrograms/kg. Radioimmunoassay study showed that the CCK-8 immunoreactivity (IR) in the cerebrocortex and hippocampus is much lower in P77PMC rats than that of Wistar rats. The results suggest that a low cerebral content of CCK-8 may account for the high susceptibility of audiogenic seizure in P77PMC rats.
Zhang
L X
LX
Neuroscience Research Center, Beijing Medical University, China.
Zhou
Y
Y
Du
Y
Y
Han
J S
JS
D000161:Acoustic Stimulation / Q000009:adverse effects*; D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry* / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D006624:Hippocampus / Q000737:chemistry* / Q000187:drug effects; D007274:Injections, Intraperitoneal; D051381:Rats; D011922:Rats, Mutant Strains / Q000502:physiology*; D017208:Rats, Wistar; D012720:Severity of Illness Index; D012844:Sincalide / Q000008:administration & dosage / Q000032:analysis / Q000172:deficiency / Q000627:therapeutic use*
D012844:Sincalide