title: Periurethral polytetrafluoroethylene paste injection in incontinent female subjects: surgical indications and improved surgical technique.
abstract: We present the results with 2 techniques for periurethral polytetrafluoroethylene (Polytef) injection in 21 female subjects with type III stress urinary incontinence. The standard technique included the use of a stainless steel needle for injection, paste "sopping" and a Wolff, Storz or Lewy syringe as an injecting element. Postoperatively, no catheters were left indwelling and all patients were encouraged to urinate following recovery from the anesthesia. The modified technique included the use of a 14F angio-catheter for injection of the paste, paste heating and a Lewy syringe or Mentor gun as injector. Postoperatively, all patients were left with an indwelling suprapubic catheter for 3 to 5 days. A total of 27 injections was performed, including 9 with the standard technique and the last consecutive 18 with the modified technique. Average followup has been 11.4 months. Cure, improvement and no change rates from the preoperative condition were 11%, 22% and 67% with the standard technique and 39%, 17% and 44% with the modified technique, respectively. In the latter group 3 patients had received pelvic radiotherapy as definitive treatment for pelvic malignancies. The overall failure rate in patients with a stable detrusor was 42% compared to 75% in the group with bladder instability and low compliance. Advantages of the modified technique include avoidance in the formation of intraoperative and postoperative fistulas, and easier handling and injection of the heated paste to achieve urethral compression. Improved short-term results with the modified technique indicate that a larger group of patients and long-term followup are essential requirements to determine the true efficacy of this technical modification. Based on these preliminary results, we now prefer the modified technique to the standard technique in the management of type III stress urinary incontinence.
authors.affiliation: Department of Surgery, University of South Florida Health Sciences Center, H. Lee Moffitt Cancer and Research Institute, Tampa.
authors.forename: R
authors.initials: R
authors.lastname: Lotenfoe
authors.forename: J K
authors.initials: JK
authors.lastname: O'Kelly
authors.forename: M
authors.initials: M
authors.lastname: Helal
authors.forename: J L
authors.initials: JL
authors.lastname: Lockhart
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011138:Polytetrafluoroethylene / Q000008:administration & dosage*; D016896:Treatment Outcome; D014521:Urethra; D014550:Urinary Incontinence, Stress / Q000601:surgery / Q000628:therapy*
chemical_list: D011138:Polytetrafluoroethylene