title: Possible association of ischemic stroke with phentermine.
abstract: OBJECTIVE
  Some commonly used anorexiants, including methamphetamine and phenylpropanolamine, have been associated with stroke. Because phentermine is an anorexiant with a chemical structure similar to that of amphetamines, similar side effects might be expected.
  
  
  METHODS
  Two patients using phentermine (one was also using phendimetrazine) developed ischemic cerebrovascular disease. One suffered a cerebral infarct with angiographic evidence of vasculopathy involving multiple vascular beds. The other patient developed headache and a hemisensory disturbance of 7 days' duration.
  
  
  CONCLUSIONS
  Phentermine, and possibly phendimetrazine, should be considered an anorexiant and sympathomimetic drug that can be associated with ischemic cerebrovascular disease.
authors.affiliation: Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, MI 48202-2689.
authors.forename: J
authors.initials: J
authors.lastname: Kokkinos
authors.forename: S R
authors.initials: SR
authors.lastname: Levine
mesh_terms: D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects*; D002545:Brain Ischemia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009025:Morpholines / Q000009:adverse effects*; D010645:Phentermine / Q000009:adverse effects*; D011859:Radiography
chemical_list: D001067:Appetite Depressants; D009025:Morpholines; C100294:phendimetrazine; D010645:Phentermine