title: Longitudinal study of bone age in acute lymphoblastic leukaemia.
abstract: Bone age was assessed in children with acute lymphoblastic leukaemia (ALL) using the Tanner-Whitehouse II method. X-rays of the left hand (wrist) were made at diagnosis and annually until 5 years after diagnosis. A total of 164 X-rays from 40 patients was available. During treatment bone age development as well as height growth was retarded in relation to calendar age. A catch-up of bone age and height was observed in the 2 years after cessation of treatment. No significant differences could be found between patients with and without cranial irradiation as central nervous system treatment. Therefore cranial irradiation alone is not responsible for the growth retardation of children with ALL; the causative role of cytostatic drug therapy and/or corticosteroids has to be investigated.
authors.affiliation: Department of Pediatrics, University Hospital, University of Groningen, The Netherlands.
authors.forename: R Y
authors.initials: RY
authors.lastname: Tamminga
authors.forename: M
authors.initials: M
authors.lastname: Zweens
authors.forename: W
authors.initials: W
authors.lastname: Kamps
authors.forename: N
authors.initials: N
authors.lastname: Drayer
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001846:Bone Development / Q000187:drug effects / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000009:adverse effects; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000503:physiopathology* / Q000532:radiotherapy