Evolution of clinical understanding: paroxysmal nocturnal hemoglobinuria as a paradigm.
In recounting the history of the development of knowledge about PNH, the roles of the clinician, the basic scientist, and the clinician-investigator are apparent. Without the observations of the clinicians, the problem could not be posed. Without the contributions from basic science (the biochemistry of complement, the biology of glycosyl-phosphatidylinositol anchors, etc), the information necessary to the solution of the problem would not be available. Without the synthesis of the clinician-investigator, the two elements would not be fused to result in knowledge about the disease.
Rosse
W F
WF
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
D000818:Animals; D003165:Complement System Proteins / Q000502:physiology; D006405:Hematology / Q000266:history* / Q000379:methods; D006457:Hemoglobinuria, Paroxysmal / Q000266:history* / Q000378:metabolism; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D014345:Trypanosoma / Q000502:physiology
D003165:Complement System Proteins