Extremity transplantation: a review of its current state of development.
The discovery of a powerful immunosuppressive, cyclosporin A, together with the development of a microsurgical free tissue transfer technique, has brought extremity transplantation closer to being a realistic possibility. In this review the authors describe the history of laboratory research into extremity transplantation before immunosuppression, with early immunosuppressive agents, with cyclosporin A, and with FK-506, one of a new generation of immunosuppressives.
Nolan
L M
LM
Division of Orthopaedic Surgery, University of Toronto, Toronto General Hospital, Ontario, Canada.
Bowen
V
V
D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage; D005121:Extremities / Q000601:surgery*; D006801:Humans; D014180:Transplantation
D016572:Cyclosporine