Methotrexate and reproduction in men: case report and recommendations.
Methotrexate has been used in the treatment of recalcitrant psoriasis for more than 35 years. We examined the significance of impaired spermatogenesis in a young man undergoing methotrexate treatment for severe psoriasis with associated arthritis. A medical geneticist was consulted and a review of the literature was performed. Genetic abnormalities that could lead to mutagenesis include chromosomal abnormalities and single-gene mutations. These aspects are considered and recommendations are made for counseling men undergoing methotrexate therapy so that risks and options can be considered.
Morris
L F
LF
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas.
Harrod
M J
MJ
Menter
M A
MA
Silverman
A K
AK
D000328:Adult; D001168:Arthritis / Q000150:complications; D002869:Chromosome Aberrations / Q000139:chemically induced; D025063:Chromosome Disorders; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D009154:Mutation; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D013091:Spermatogenesis / Q000187:drug effects*
D008727:Methotrexate