Early divergence of erythroid lineage suggested by gene rearrangements in mouse hematopoietic neoplasms.
A total of 113 primary murine hematopoietic neoplasms, including those of erythroid, granulocytic, and T and B lymphoid lineages, were examined for rearrangement of immunoglobulin heavy (IgH) and kappa light chain (IgK) and T cell receptor beta and gamma (TcR-beta and TcR-gamma) genes. There was a total absence of Ig or TcR gene rearrangements in erythroid leukemias. In contrast, overlaps of IgH rearrangements were observed in myeloid and T cell as well as B cell neoplasms. In a minority of B cell lymphomas, rearrangements of TcR-beta or TcR-gamma genes were detected. This evidence of shared recombinase activity for myeloid, T cell, and B cell-lineage tumors and the absence of such activity in erythroid tumors suggest early divergence of the erythroid pathway.
Fredrickson
T N
TN
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Hartley
J W
JW
Morse
H C
HC
D000818:Animals; D004900:Erythroblasts / Q000473:pathology*; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood* / Q000235:genetics*; D007942:Leukemia, Experimental / Q000097:blood* / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000097:blood* / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000097:blood / Q000235:genetics; D016399:Lymphoma, T-Cell / Q000097:blood / Q000235:genetics; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta