title: Pneumococcal arthritis after allogeneic bone marrow transplantation.
abstract: We report a case of pneumococcal arthritis occurring in a 15-year-old boy following allogeneic BMT. The post-transplant course was complicated by GVHD requiring prolonged immunosuppressive therapy. He experienced recurrent infections, including pneumococcal pneumonia. Thirty-five months after BMT and 12 months after the pneumococcal pneumonia, pneumococcal arthritis of the left knee occurred. This is the first reported case of arthritis caused by Streptococcus pneumoniae after allogeneic BMT. Penicillin prophylaxis may be used to prevent recurrence of pneumococcal infections in patients with chronic GVHD.
authors.affiliation: Medizinische Klinik mit Schwerpunkt Hämatologie/Onkologie, Freie Universität Berlin, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Schwella
authors.forename: R
authors.initials: R
authors.lastname: Schwerdtfeger
authors.forename: I
authors.initials: I
authors.lastname: Schmidt-Wolf
authors.forename: H
authors.initials: H
authors.lastname: Schmid
authors.forename: W
authors.initials: W
authors.lastname: Siegert
mesh_terms: D000293:Adolescent; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000209:etiology*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D010406:Penicillins / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000209:etiology*; D013296:Streptococcus pneumoniae
chemical_list: D010406:Penicillins