Reinvestigation of the transmembrane difference in 7Li NMR T1 values in Li(+)-loaded human erythrocyte suspensions.
In contrast to the findings in a recent study (R. P. Gullapalli, R. M. Hawk, R. A. Komoroski, Magn. Reson. Med. 20, 240 (1991)), we found that, even at high hematocrits, the T1 values for extracellular 7Li were at least three times longer than those for intracellular Li+. We conclude that a transmembrane difference in T1 values can be used for separate observation of intracellular and extracellular Li+ in human red blood cell suspensions.
Mota de Freitas
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Department of Chemistry, Loyola University of Chicago, Illinois 60626.
Rong
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D001693:Biological Transport, Active; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006400:Hematocrit; D006801:Humans; D007554:Isotopes; D008094:Lithium / Q000097:blood / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D008564:Membrane Potentials; D015203:Reproducibility of Results
D007554:Isotopes; D008094:Lithium