title: Effect of percutaneous balloon mitral valvuloplasty on serum creatinine phosphokinase MB-isoenzyme levels.
abstract: Twenty-one patients with moderate to severe mitral stenosis were treated with percutaneous balloon mitral valvuloplasty (PBMV) using Inoue mitral double-lumen balloon catheters. Creatinine phosphokinase MB isoenzyme (CPK-MB) levels were measured at baseline, 5 min, 6 h, and 18 h post dilatation. Haemodynamic indexes, 12-lead ECGs, and 2-dimensional echocardiograms were performed to evaluate systolic function postprocedure. CPK-MB levels were modestly increased at 5 min and at 6 h postprocedure compared with the baseline level (p < 0.001) but were still within the normal reference range, except for one patient who had a level at 5 min minimally above the upper limit of normal. CPK-MB levels were not significantly increased at 18 h after the procedure. No significant changes in ejection fractions, 12-lead ECGs, and regional wall motion occurred in any of the patients studied. In conclusion, PBMV causes modest early elevation of CPK-MB. This elevation is not associated with changes in LV systolic function and does not interfere with the diagnosis of acute myocardial infarction using the enzyme elevation criteria.
authors.affiliation: Department of Cardiology and Pathology, Grantham Hospital, Aberdeen, Hong Kong.
authors.forename: A S
authors.initials: AS
authors.lastname: Yip
authors.forename: W H
authors.initials: WH
authors.lastname: Chow
authors.forename: K H
authors.initials: KH
authors.lastname: Fu
authors.forename: K L
authors.initials: KL
authors.lastname: Cheung
authors.forename: J P
authors.initials: JP
authors.lastname: Li
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
mesh_terms: D000328:Adult; D002404:Catheterization / Q000009:adverse effects; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D004452:Echocardiography; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000628:therapy*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase