Dynamics of the immune system response in cerebrospinal fluid and blood of SIVmac-infected rhesus monkeys.
Paired sera and CSF samples were collected from SIVmac-infected macaques. Animals infected with SIVmac251 maintained low gag and high env-specific antibody levels in plasma. Increasing env-specific antibody titers in CSF were associated in one animal with strong intrathecal synthesis. SIVmac239-infected monkeys revealed high antibody titers of gag and env-specificity, in one animal accompanied by weak intrathecal synthesis of virus-specific antibodies. In all animals, the CD4/CD8 ratio in CSF decreased faster compared to blood.
Sopper
S
S
Institut für Virologie und Immunbiologie, Universität Würzburg, Germany.
Hemm
S
S
Meixensberger
J
J
Coulibaly
C
C
Stahl-Hennig
C
C
Hunsmann
G
G
Fleckenstein
B
B
ter Meulen
V
V
Dörries
R
R
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood* / Q000134:cerebrospinal fluid*; D000918:Antibody Specificity; D016516:CD4-CD8 Ratio; D015686:Gene Products, env / Q000276:immunology; D015683:Gene Products, gag / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000382:microbiology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000302:isolation & purification; D013997:Time Factors
D000914:Antibodies, Viral; D015686:Gene Products, env; D015683:Gene Products, gag; D007074:Immunoglobulin G