[Dependence of the load of hereditary diseases on the level of endogamy of the Russian population].
Relationship between the index of endogamy and a random component of inbreeding in Russian populations was studied. It was shown that significant correlation (r = 0.74 +/- 0.24) exists between these parameters. Correlation coefficient between the index of endogamy and the load of autosome recessive pathology makes up 0.98 + 0.11. It is suggested that the index of endogamy could be used as a quantitative measure of genetic structure of the population where it is not possible to receive the inbreeding value using the routine methods.
Brusintseva
O V
OV
El'chinova
G I
GI
D003241:Consanguinity; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D012426:Russia