title: Evaluation of site-specific chemotherapeutic agents in periodontal treatment.
abstract: The rapid evolution of chemotherapeutic agents and site-specific treatment of adult periodontitis using controlled delivery systems require critical evaluation by the clinician. At present there are no defined guidelines to assist clinicians in their decision-making process. This paper offers background information and guidelines that can be applied to new and established chemotherapeutic agents and site-specific controlled delivery treatment modalities. The guidelines are not intended to be all inclusive or represent a definitive treatise on the subject. However, it is hoped that the factors addressed will serve as impetus for a discriminating consideration of the problems inherent to the evaluation of new therapeutic products, particularly those intended for use as site-specific controlled delivery modalities in the treatment of adult periodontitis.
authors.affiliation: University of Missouri-Kansas City.
authors.forename: C M
authors.initials: CM
authors.lastname: Cobb
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003773:Dental Plaque / Q000517:prevention & control; D016503:Drug Delivery Systems; D004341:Drug Evaluation; D006801:Humans; D010518:Periodontitis / Q000188:drug therapy*; D012107:Research Design
chemical_list: D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents