Gamma probe assisted ex vivo detection of small lymph node metastases following the administration of indium-111-labeled monoclonal antibodies to colorectal cancers.
This study evaluated the ability of ex vivo gamma-probe scanning to detect lymph node metastases in resected surgical specimens from primary colorectal carcinoma patients undergoing external scintigraphy following intravenous administration of 4.1-5.3 mCi of 111In-labeled anti CEA monoclonal antibodies. The ex vivo probe counting technique led to a twofold to fourfold increase in the number of detectable lymph nodes with the majority measuring 2-5 mm in diameter. Results indicate a potentially useful role for ex vivo probe counting in detection and mapping small (2-5 mm) lymph nodes metastases.
Abdel Nabi
H
H
Department of Nuclear Medicine, State University of New York at Buffalo 14214.
Doerr
R J
RJ
Balu
D
D
Rogan
L
L
Farrell
E L
EL
Evans
N H
NH
D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D015902:Gamma Cameras; D006801:Humans; D066298:In Vitro Techniques; D007205:Indium Radioisotopes; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008722:Methods; D008875:Middle Aged; D011446:Prospective Studies; D016719:Radioimmunodetection
D007205:Indium Radioisotopes