title: Ranitidine has no effect on postbreakfast ethanol absorption.
abstract: The effect of ranitidine, the H2-receptor antagonist, on the systemic bioavailability of ethanol (0.3 g/kg body weight) taken orally 1 h after breakfast, was investigated in a randomized, placebo-controlled, double-blind cross-over study. Twenty normal male subjects (age, 19-26 yr) were studied on the morning of the 8th day of twice-daily dosing with either 150 mg ranitidine or placebo. Plasma ethanol concentration was measured by the alcohol dehydrogenase method from 0 to 240 min after oral ingestion of ethanol (100% ethanol made up to 200 ml orange juice). Compared with placebo, dosing with ranitidine resulted in nonsignificant changes in either the mean integrated 4-h plasma ethanol concentration (27.8 vs. 32.4 mg.h/dl), the peak plasma ethanol concentration (18.0 vs. 21.1 mg/dl), or the time to peak (43 vs. 40 min). There is no clinically important interaction between ranitidine and a low dose of ethanol taken orally 1 h after breakfast.
authors.affiliation: University Department of Medicine, Royal Free Hospital School of Medicine, London, England.
authors.forename: A G
authors.initials: AG
authors.lastname: Fraser
authors.forename: M
authors.initials: M
authors.lastname: Hudson
authors.forename: A M
authors.initials: AM
authors.lastname: Sawyerr
authors.forename: M S
authors.initials: MS
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Sercombe
authors.forename: S B
authors.initials: SB
authors.lastname: Rosalki
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004311:Double-Blind Method; D000431:Ethanol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005502:Food; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*
chemical_list: D000431:Ethanol; D011899:Ranitidine