title: Comparison of CT and MRI in the evaluation of therapeutic response in thoracic Hodgkin disease.
abstract: Current imaging modalities are accurate in establishing the diagnosis and extent of thoracic Hodgkin disease. After treatment, however, it is extremely difficult to differentiate potential residual active neoplastic disease from scar tissue, or identify early recurrence. We evaluated the contribution of MRI in the assessment of the response to treatment of thoracic Hodgkin disease in the assumption that scar formation would be characterized by low signal intensity in all pulse sequences, whereas active tumor should maintain a degree of high signal intensity on T2-weighted images. In 47 occasions (23 patients) both CT and MRI were able to identify correctly active disease, but had low specificity in confirming remission because of residual tissues masses. High signal intensity on T2-weighted MR images often persisted despite remission, probably because of edema, necrosis, granulation or other factors. MRI was somewhat more specific than CT and may be quite valuable to confirm remission in patients with residual masses that no longer appear hyperintense on T2 after treatment.
authors.affiliation: Department of Radiology, Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, NY 11042.
authors.forename: S S
authors.initials: SS
authors.lastname: Elkowitz
authors.forename: J C
authors.initials: JC
authors.lastname: Leonidas
authors.forename: M
authors.initials: M
authors.lastname: Lopez
authors.forename: I
authors.initials: I
authors.lastname: Cherick
authors.forename: R G
authors.initials: RG
authors.lastname: Schiff
authors.forename: G
authors.initials: G
authors.lastname: Karayalcin
authors.forename: P
authors.initials: P
authors.lastname: Lanzkowsky
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D013899:Thoracic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D014057:Tomography, X-Ray Computed