title: Effects of alpha 1-receptor blockade on the cardiovascular and thermoregulatory responses to severe exercise in the heat.
abstract: Up to an internal temperature of 38 degrees C, nonacral skin blood flow increases with mild exercise in a warm environment. While this appears to be due predominately to an active vasodilator system and not to altered vasoconstrictor activity, it is uncertain if more intense exercise affects this vasodilator response. Consequently, six fit (VO2pk = 62.8 +/- 2.2 ml.kg-1.min-1, mean +/- SEM) college aged men performed 30 min bouts of cycle ergometry exercise at 70% VO2pk in a hot environment (35 degrees C, 55% rh) while under the influence of either an alpha 1-receptor blocker (prazosin, PRAZ) or a placebo (CTL). Resting rectal temperature (Tre) was lower (p = 0.002) and heart rate (HR) higher (p = 0.018) during PRAZ. Neither resting nor exercise forearm blood flow (FBF, plethysmography) and forearm vascular conductance (FVC) differed between PRAZ and CTL. Exercise Tre and mean skin temperature (Tsk) did not differ significantly between treatments, rising to 38.7 and 36.4 degrees C, respectively, by the 30th min of exercise. Exercise HR was 4 beats.min-1 higher (p = 0.016) with PRAZ. Mean arterial pressure (MAP) did not differ significantly between drug treatments, As FBF, FVC, Tre, Tsk and MAP were similar between treatments while only HR was significantly affected by PRAZ, it appears that alpha 1-receptor blockade does not alter the thermoregulatory responses to severe exercise in the heat. However, the elevated HR in the presence of a stable MAP suggests that central venous return may have been attenuated during PRAZ.
authors.affiliation: Laboratory for Exercise, Sport and Work Physiology, Virginia Polytechnic Institute and State University, Blacksburg.
authors.forename: W D
authors.initials: WD
authors.lastname: Franke
authors.forename: M S
authors.initials: MS
authors.lastname: Hickey
authors.forename: C W
authors.initials: CW
authors.lastname: Ward
authors.forename: K P
authors.initials: KP
authors.lastname: Davy
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D005080:Exercise Test; D005542:Forearm / Q000098:blood supply; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006358:Hot Temperature; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D010919:Placebos; D011224:Prazosin / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D016526:Workload
chemical_list: D010919:Placebos; D011224:Prazosin