[Neutrophilic myelofibrosis; a case report].
A 53-year-old male was admitted to our hospital with abdominal pain. Physical examination revealed marked splenomegaly. The white blood cell count increased to 5.8 x 10(4)/microliters. Bone marrow biopsy showed hypercellularity with a moderate increase in reticulin fiber. Chromosomal analysis showed 47, XY, +9q-, -9q- without Ph1 chromosome and bcr-abl rearrangement. MCNU therapy was successful in reducing the white blood cell count and splenomegaly. It is likely that the diagnosis of our patient is compatible with the neutrophilic myelofibrosis described by Stewart, et al.
Okamoto
R
R
First Department of Internal Medicine, Yokohama City University School of Medicine.
Harano
H
H
Tamura
T
T
Tanabe
J
J
Fujita
H
H
Fukawa
H
H
Kanamori
H
H
Matsuźaki
M
M
Motomura
S
S
Mohri
H
H
D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D055728:Primary Myelofibrosis / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology