title: [A study on uric acid excretion in patients with hypouricemia].
abstract: We studied four patients with hypouricemia and almost normal renal function. Two patients are idiopathic renal and familial. The other two cases are secondary to diabetes mellitus. The study of the uricosuric mechanism with pyrazinamide (PZA) and benzbromarone (Bb) test shows that two patients have a defect of pre-secretory reabsorption of urate, the other one a incomplete combined defect of pre-and post-secretory reabsorption, and the other one a enhanced secretion of urate. The fact that two patients have the history of acute renal failure (ARF) suggested that strenuous exercise or dehydration would be responsible for ARF in patients with renal hypouricemia.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hiroshige
authors.forename: K
authors.initials: K
authors.lastname: Yuu
authors.forename: M
authors.initials: M
authors.lastname: Takasugi
authors.forename: M
authors.initials: M
authors.lastname: Soejima
authors.forename: A
authors.initials: A
authors.lastname: Kuroiwa
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism; D001553:Benzbromarone; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D011718:Pyrazinamide; D001553:Benzbromarone