title: Recent advances in molecular and genetic analysis of Rh blood group structures.
abstract: The Rh antigens are carried by 30-32 kDa integral proteins of the red cell membrane. The Rh locus is composed of two genes: RhD, which encodes the major D antigen and is present only in Rh-positive genomes, and RhCcEe, which encodes both the Cc and Ee polypeptides, most likely by alternative splicing events. The D and non-D Rh mRNAs have been cloned. Their sequence homology suggest that the two Rh genes have evolved by duplication of a common ancestor.
authors.affiliation: Unité INSERM U76, Institut National de Transfusion Sanguine, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Colin
authors.forename: B
authors.initials: B
authors.lastname: Cherif-Zahar
authors.forename: C
authors.initials: C
authors.lastname: Le Van Kim
authors.forename: I
authors.initials: I
authors.lastname: Mouro
authors.forename: J P
authors.initials: JP
authors.lastname: Cartron
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D004910:Erythrocyte Membrane / Q000737:chemistry; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics; D012204:Rh-Hr Blood-Group System / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D012204:Rh-Hr Blood-Group System