title: Mechanisms of bone loss associated with total hip replacement.
abstract: The pathogenesis of bone loss after total hip arthroplasty is discussed. Two separate processes are considered: adaptive bone remodeling ("stress-shielding") and osteolysis. Clinical and experimental studies that provide the basis for current and future strategies to minimize the occurrence and severity of these phenomena are summarized.
authors.affiliation: Department of Orthopedic Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois.
authors.forename: J J
authors.initials: JJ
authors.lastname: Jacobs
authors.forename: D R
authors.initials: DR
authors.lastname: Sumner
authors.forename: J O
authors.initials: JO
authors.lastname: Galante
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D010014:Osteolysis / Q000503:physiopathology