Induction of phosphatidic acid by fibroblast growth factor in cultured baby hamster kidney fibroblasts.
Basic fibroblast growth factor (bFGF/FGF-2) is a strong mitogenic inducer of cultured baby hamster kidney (BHK) cells. When cultured BHK cells were stimulated with FGF-2, phosphatidic acid (PA) was induced within 2 min, peaked at 5 min and gradually decreased. Phospholipase D (PLD) was also mitogenic for cultured BHK cells and this effect was mediated via PA. The possibility that PA induction by FGF-2 is an essential signaling step for BHK cell proliferation is discussed.
Motoike
T
T
Department of Anatomy and Cell Biology, University of Heidelberg, Germany.
Bieger
S
S
Wiegandt
H
H
Unsicker
K
K
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D004075:Diglycerides / Q000096:biosynthesis; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008934:Mitogens / Q000494:pharmacology; D010712:Phosphatidic Acids / Q000096:biosynthesis*; D010739:Phospholipase D / Q000502:physiology
D004075:Diglycerides; D008934:Mitogens; D010712:Phosphatidic Acids; D005346:Fibroblast Growth Factors; D010739:Phospholipase D