title: Early morphogenesis of persistent hyperplastic tunica vasculosa lentis and primary vitreous (PHTVL/PHPV). Scanning electron microscopic observations.
abstract: This study provides scanning electron microscopic observations on the early morphogenesis of persistent hyperplastic tunica vasculosa lentis and primary vitreous (PHTVL/PHPV) in canine fetuses at days 28 35 postcoitum (D28 and D35). From previous studies regarding PHTVL/PHPV it is known that a retrolental plaque of fibrovascular tissue is present in eyes of affected canine fetuses from the D33 stage. The contribution of vitreous cells to the formation of the plaque is supported by the results of this study. The lens capsules at the stages described were not found to contain abnormalities such as transparent (thinner) parts or rents, as have been described for postnatal cases of PHTVL/PHPV. These findings support the hypothesis that the capsular anomalies observed in postnatal patients are secondary entities.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Boevé
authors.forename: G F
authors.initials: GF
authors.lastname: Vrensen
authors.forename: B L
authors.initials: BL
authors.lastname: Willekens
authors.forename: F C
authors.initials: FC
authors.lastname: Stades
authors.forename: J S
authors.initials: JS
authors.lastname: van der Linde-Sipman
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005333:Fetus; D006965:Hyperplasia; D007498:Iris / Q000196:embryology / Q000648:ultrastructure; D007903:Lens Capsule, Crystalline / Q000196:embryology / Q000648:ultrastructure; D007908:Lens, Crystalline / Q000196:embryology* / Q000648:ultrastructure*; D009024:Morphogenesis; D014822:Vitreous Body / Q000196:embryology* / Q000648:ultrastructure*