title: Akinetic-rigid syndrome in a 13-year-old girl with HIV-related progressive multifocal leukoencephalopathy.
abstract: A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.
authors.affiliation: Department of Neurology, University of Miami School of Medicine, Florida.
authors.forename: C
authors.initials: C
authors.lastname: Singer
authors.forename: J R
authors.initials: JR
authors.lastname: Berger
authors.forename: B C
authors.initials: BC
authors.lastname: Bowen
authors.forename: J H
authors.initials: JH
authors.lastname: Bruce
authors.forename: W J
authors.initials: WJ
authors.lastname: Weiner
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology; D000293:Adolescent; D001706:Biopsy; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009069:Movement Disorders / Q000175:diagnosis* / Q000473:pathology; D009127:Muscle Rigidity / Q000175:diagnosis* / Q000473:pathology; D009186:Myelin Sheath / Q000473:pathology; D009460:Neurologic Examination