title: The distribution of type 1 chain ABH and related histo-blood group antigens in normal cycling human endometrium.
abstract: Cycling endometrial tissue was examined immunohistochemically for blood group antigens using a panel of monoclonal antibodies with specificity to type 1 chain carbohydrates. Staining was evaluated against the genetic background (ABO, Lewis, and saliva-secretor status) and the subphase of the menstrual cycle. Expression of type 1 chain antigens in most cases correlated with the genetic background; however, Le(a) and Le(b) antigens were in a few cases demonstrated in endometria with the erythrocyte Le(a-b-) phenotype and Le(b) antigen in erythrocyte Le(a + b-) endometria also. In addition, Le(b) antigen was preferentially expressed in endometria from blood group O individuals. Type 1 chain antigens were, in general, maximally demonstrated in the surface epithelium. Chain 1 A, H, ALe(b), Le(a), and disialosyl-Le(a) (dsLe(a)) determinants were demonstrated only sporadically in functionalis and basalis glands of cycling endometria. Staining for most type 1 chain antigens showed variations that were related to the histomorphology (layer and menstrual phase), and monosialosyl-Le(a) (msLe(a)) seemed to be a marker of secretory differentiation in the endometrium. Our results support the view that synthesis and expression of type 1 chain antigens in human endometrium is influenced by the genetic background and is modulated by the hormonal environment.
authors.affiliation: Department of Pathology, University Hospital, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: V
authors.initials: V
authors.lastname: Ravn
authors.forename: C S
authors.initials: CS
authors.lastname: Teglbjaerg
authors.forename: U
authors.initials: U
authors.lastname: Mandel
authors.forename: E
authors.initials: E
authors.lastname: Dabelsteen
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis*; D000328:Adult; D000911:Antibodies, Monoclonal; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007983:Lewis Blood Group Antigens / Q000032:analysis*; D008597:Menstrual Cycle / Q000097:blood*
chemical_list: D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D007983:Lewis Blood Group Antigens