title: Plasma concentrations of bupivacaine after wound infiltration of an 0.5% solution after inguinal herniorrhaphy: a preliminary study.
abstract: After routine inguinal herniorrhaphy we gave 12 patients a wound infiltration regimen of bolus doses of 20 ml of 0.5% bupivacaine via a catheter within the wound and rectally administered indomethacin (100 mg). Peak venous plasma bupivacaine concentrations ranged from 0.07 mg.l-1 to 1.14 mg.l-1 (mean (SD) 0.47 (0.33) mg.l-1), and occurred at between 0.25 and 2 h after the first dose. Plasma concentrations were well below the toxic threshold of 4 mg.l-1 and there was no accumulation. The regimen provided satisfactory analgesia. There were no wound infections nor signs of toxicity.
authors.affiliation: Department of Pharmacy, University of Queensland, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Kastrissios
authors.forename: E J
authors.initials: EJ
authors.lastname: Triggs
authors.forename: F
authors.initials: F
authors.lastname: Sinclair
authors.forename: P
authors.initials: P
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Smithers
mesh_terms: D000328:Adult; D000368:Aged; D002045:Bupivacaine / Q000008:administration & dosage* / Q000097:blood*; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy
chemical_list: D002045:Bupivacaine