title: A comparison of rest sestamibi and rest-redistribution thallium single photon emission tomography: possible implications for myocardial viability detection in infarcted patients.
abstract: Thirty patients (26 men, 4 women, mean age 61 +/- 8 years) who had suffered myocardial infarction 15 +/- 6 months previously, were submitted to (1) standard stress-redistribution thallium-201 single photon emission tomography (SPET), (2) rest-redistribution 201T1 SPET and (3) stress-rest technetium-99m sestamibi SPET. Uptake modifications in relation to exercise-induced defects were evaluated in a total of 390 myocardial segments. Tracer uptake was scored as normal (=0), mildly reduced (=1), apparently reduced (=2), severely reduced (=3) or absent (=4). Comparison of stress studies failed to show any statistical difference (58% segmental abnormalities with sestamibi vs 61% with thallium). Uptake abnormalities (score 1-4) were detected in 55% of the segments with sestamibi, 55% with standard thallium redistribution, 55% with early imaging after thallium injection at rest and 54% with 3-h delayed rest imaging (P = NS). Absence of tracer uptake (score = 4) under resting conditions was recorded in 75 (19%) segments with standard 201T1 redistribution, 75 (19%) with rest sestamibi, 70 (18%) with rest 201T1 imaging and 62 (16%) with rst-redistribuion 201T1 (P < 0.05 vs other imaging modalities). Thus, 3-h delayed rest thallium imaging detected reversibility of uptake defects in a significantly higher number of myocardial segments. This finding might have important implications for both tracer and technique selection when myocardial viability is the main clinical issue.
authors.affiliation: Department of Nuclear Medicine, S. Orsola-Malpighi Policlinic Hospital, Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dondi
authors.forename: F
authors.initials: F
authors.lastname: Tartagni
authors.forename: F
authors.initials: F
authors.lastname: Fallani
authors.forename: S
authors.initials: S
authors.lastname: Fanti
authors.forename: M
authors.initials: M
authors.lastname: Marengo
authors.forename: I
authors.initials: I
authors.lastname: DiTommaso
authors.forename: Q F
authors.initials: QF
authors.lastname: Zheng
authors.forename: N
authors.initials: N
authors.lastname: Monetti
mesh_terms: D002470:Cell Survival / Q000502:physiology; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi