Monocyte antimycobacterial activity before and after Mycobacterium bovis BCG vaccination in Chingleput, India, and London, United Kingdom.
Monocytes from purified protein derivative S Mantoux-negative children and young adults inhibited intracellular growth of Mycobacterium microti more in Chingleput than in London. Mycobacterium bovis BCG vaccination did not enhance bacteriostasis with the Indians but did so with the Londoners. No evidence was found for involvement of cytokines such as macrophage-activating factor and granulocyte macrophage colony-stimulating factor in the differences.
Cheng
S H
SH
Department of Bacteriology, Royal Postgraduate Medical School, London, United Kingdom.
Walker
K B
KB
Lowrie
D B
DB
Mitchison
D A
DA
Swamy
R
R
Datta
M
M
Prabhakar
R
R
D001500:BCG Vaccine / Q000276:immunology*; D001770:Blood Bactericidal Activity; D006801:Humans; D007194:India; D016215:Macrophage-Activating Factors / Q000378:metabolism; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology; D009161:Mycobacterium / Q000254:growth & development / Q000276:immunology*; D006113:United Kingdom
D001500:BCG Vaccine; D016215:Macrophage-Activating Factors