The biology of interleukin-5 and its receptor.
IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infections with tissue-dwelling parasites and a diverse group of hypereosinophilic conditions of no known etiology. Our understanding of the biological role of IL-5 in the regulation of Ig production and the development of immunity to parasites is far from complete, but basic knowledge of its action at the cellular level is accumulating and will be critical for the intelligent application of immunotherapy with IL-5 or antibodies to IL-5 in infectious, neoplastic, and possibly other diseases.
Mahanty
S
S
Clinical Parasitology Section, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland.
Nutman
T B
TB
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004804:Eosinophils / Q000187:drug effects; D005786:Gene Expression Regulation; D006801:Humans; D015848:Interleukin-5 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D051381:Rats; D018123:Receptors, Interleukin / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D053649:Receptors, Interleukin-5
D015848:Interleukin-5; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5