title: Inhibition of protein synthesis during repetitive cortical spreading depression.
abstract: The effect of cortical spreading depression (CSD) on cerebral protein synthesis (CPS) was examined. CSD was evoked in normal rats with KCl, and CPS was measured autoradiographically with [1-14C]leucine. Average rates (mean +/- SD) of CPS in layers I-IV of cortex decreased significantly from 10.7 +/- 0.6 (sham-operated controls; n = 4) to 6.7 +/- 0.7 nmol/g/min (n = 4; p < 0.01) and in layers V-VI from 10.9 +/- 0.5 to 9.4 +/- 0.4 nmol/g/min (p < 0.05) during 60 min of repetitive CSD. Spreading depression did not affect CPS rates in other subcortical brain regions. These results indicate that KCl-evoked CSD induces inhibition but not suppression of cortical protein synthesis.
authors.affiliation: Department of Experimental Neurology, Max-Planck-Institute for Neurological Research, Cologne, F.R.G.
authors.forename: G
authors.initials: G
authors.lastname: Mies
mesh_terms: D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D013181:Cortical Spreading Depression; D004569:Electroencephalography; D005260:Female; D011189:Potassium Chloride / Q000494:pharmacology; D014176:Protein Biosynthesis; D011506:Proteins / Q000037:antagonists & inhibitors*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D011506:Proteins; D011189:Potassium Chloride