title: Study of HLA antigens in patients with osteosarcoma.
abstract: HLA typing was carried out in a group of twenty-four Spanish unrelated patients diagnosed with conventional high-grade osteosarcoma. All of them were typed for HLA-A and HLA-B antigens. A significant increase in the HLA-A11 (33.3 vs. 12%, chi 2 = 9.752, corrected p value = 0.016) and HLA-B7 (33.3 vs. 11.3%, chi 2 = 10.919, corrected p value = 0.011) was found in osteosarcoma patients compared with the control group. A trend towards an increased frequency in HLA-A24 and HLA-A28 antigens was also found.
authors.affiliation: Department of Pediatrics, Universitary Clinic, School of Medicine, University of Navarra, Pamplona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Barona
authors.forename: L
authors.initials: L
authors.lastname: Sierrasesúmaga
authors.forename: F
authors.initials: F
authors.lastname: Antillón
authors.forename: I
authors.initials: I
authors.lastname: Villa-Elízaga
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000276:immunology*
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens