title: The inherent DNase of pyocin AP41 causes breakdown of chromosomal DNA.
abstract: Pyocin AP41 degrades the chromosomal DNA in sensitive strains of Pseudomonas aeruginosa but has little effect on RNA, protein, and lipid syntheses. In vitro experiments showed that the carboxyl-terminal part of the large subunit of pyocin AP41 carries an inherent DNase that is responsible for its killing action.
authors.affiliation: Department of Molecular Biology, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sano
mesh_terms: D000595:Amino Acid Sequence; D002876:Chromosomes, Bacterial / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D011709:Pyocins / Q000737:chemistry / Q000378:metabolism*; D014357:Trypsin
chemical_list: D004269:DNA, Bacterial; D010446:Peptide Fragments; D011709:Pyocins; D003851:Deoxyribonucleases; D014357:Trypsin