title: The evolution of the management of "CIN" lesions.
abstract: During the years 1961-1986 a total of 378 CIN lesions were diagnosed among 4875 women screened for cervical pathology; 285 of them were followed-up for a minimum of 5 years. All 169 cases diagnosed as CIN-3 and 18 classified as CIN-2 were treated surgically, whereas 89 patients diagnosed as CIN-1 and 65 classified as CIN-2 were treated conservatively. Finally, 37 cases (23 diagnosed as CIN-1 and 14 diagnosed as CIN-2) did not receive any treatment. Of the 187 women treated surgically, 6 (3.8%) showed, within the five year follow-up period, progression or recurrence of the disease, which necessitated either additional surgery or radiation; 5 of these cases had been classified as severe dysplasia (CIN-3). Recurrence or progression necessitating major surgery, occurred in 8 (5.1%) of the 154 patients treated conservatively; 5 of these cases were classified as moderate dysplasia (CIN-2). The data indicate that present diagnostic procedures allow a better selection of patients to be submitted to surgery, increasing the proportion of those treated conservatively, without jeopardizing their prognosis.
authors.affiliation: First Institute of Gynaecology and Obstetrics, University La Sapienza, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Napolitano
authors.forename: B
authors.initials: B
authors.lastname: Mossa
authors.forename: R
authors.initials: R
authors.lastname: Marziani
authors.forename: R
authors.initials: R
authors.lastname: Domenici
authors.forename: G
authors.initials: G
authors.lastname: Benagiano
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000601:surgery / Q000628:therapy*