Chromosome 12 alterations and c-Ki-ras mutations in colorectal tumors.
c-Ki-ras mutations and gains of chromosome 12, where this gene is mapped, were both studied in a series of 47 colorectal cancers. Mutations at codon 12 and 13 were detected in 17 (36%) and gains of chromosome 12 in 7 (15%) cases. In this sample, gains of chromosome 12 occur in tumors either with or without c-Ki-ras mutations, suggesting that gains of chromosome 12 are independent from the mutation of c-Ki-ras.
Muleris
M
M
CNRS URA 620, Institut Curie, Paris, France.
Laurent-Puig
P
P
Salmon
R J
RJ
Thomas
G
G
Dutrillaux
B
B
D002881:Chromosomes, Human, Pair 12; D015179:Colorectal Neoplasms / Q000235:genetics*; D011905:Genes, ras; D006801:Humans; D009154:Mutation