title: Tetracycline pleurodesis--associated acute renal failure.
abstract: Chemical pleurodesis is a frequently performed procedure for pneumothorax and effusion and significant adverse effects are unusual. We present a previously unreported case of acute renal failure associated with tetracycline pleurodesis. Recent studies have shown that intrapleural drug administration may lead to therapeutic serum levels. Systemic toxic drug effects may therefore be noted with chemical pleurodesants such as tetracycline. Alternative methods of pleurodesis should always be considered if a sensitivity or metabolic abnormality is suspected.
authors.affiliation: Department of General, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: W R
authors.initials: WR
authors.lastname: Smythe
authors.forename: J E
authors.initials: JE
authors.lastname: Bavaria
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D015505:Chest Tubes; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D010994:Pleura; D011030:Pneumothorax / Q000628:therapy*; D015911:Sclerotherapy; D013752:Tetracycline / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013752:Tetracycline