[Radiation exposure of cultured tissue cells and animals (mice) within 10-kilometers zone of accident at Chernobyl nuclear plant. Effect on radiosensitivity to future radiation].
The effect of chronic low-level radiation exposure on radiosensitivity to posterior acute irradiation at high doses has been studied. Cells and mice were exposed within the ten-kilometer zone of Chernobyl disaster during various spaces of time (1-12 days), then over one or more days were additionally irradiated by doses of 1-4 Gy. It was shown that no adaptive response was developed under chronic exposure of cells and mice within the zone of disaster. On the contrary increased sensitivity to posterior irradiation was revealed. The number of cytogenetic damages of cultured tissue cells and marrow cells (chromosome aberrations and micronuclei) increases, the spectrum of aberrations being shifted to chromosome type, cells with multiaberration appearing. The decay of chromatine increases indicating an interphase death; the number of leucocytes in peripheral blood decreases.
Pelevina
I I
II
Afanasév
G G
GG
Gotlib
V Ia
VIa
Alferovich
A A
AA
Antoshchina
M M
MM
Riabchenko
N I
NI
Saenko
A S
AS
Riabtsev
I A
IA
Riabov
I N
IN
D000062:Accidents, Occupational; D000818:Animals; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D009688:Nuclear Reactors; D011836:Radiation Tolerance; D013950:Thymus Gland / Q000276:immunology / Q000528:radiation effects*; D014916:Whole-Body Irradiation