Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.
The autosomal recessive scid mutation results in defective immunoglobulin and T cell receptor gene rearrangement. The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T cells and immunoglobulin, a phenotype known as "leaky." Moreover, introduction of neonatal T cells into C.B-17 scid mice leads to immunoglobulin production by 100% of animals. We have produced mice homozygous for both the scid and beige mutations. By contrast with C.B-17 scid mice, BALB/c scid.beige mice have a < 2% incidence of "leakiness." This percentage does not increase with age, and introduction of neonatal T cells fails to rescue immunoglobulin production. This suggests that a gene (or genes) closely linked to the beige locus regulates B and/or T cell development.
Mosier
D E
DE
Division of Immunology, Medical Biology Institute, La Jolla, California 92137.
Stell
K L
KL
Gulizia
R J
RJ
Torbett
B E
BE
Gilmore
G L
GL
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001402:B-Lymphocytes / Q000502:physiology*; D005803:Genes, Immunoglobulin; D006720:Homozygote; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID / Q000235:genetics*; D009154:Mutation; D013601:T-Lymphocytes / Q000502:physiology*
D007075:Immunoglobulin M