Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure.
Schimmell
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Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
D001665:Binding Sites; D002384:Catalysis; D003843:Deoxycytidine Monophosphate / Q000378:metabolism; D003856:Deoxyuracil Nucleotides / Q000378:metabolism; D016297:Mutagenesis, Site-Directed; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000737:chemistry*
D003856:Deoxyuracil Nucleotides; D003843:Deoxycytidine Monophosphate; C007267:2'-deoxyuridylic acid; D013940:Thymidylate Synthase