Interictal heart rate patterns in partial seizure disorders.
Epileptogenic mesial temporal damage may alter interictal autonomic patterning. Analysis of heart rate variability in 19 patients with complex partial seizures revealed cases of persistent, high-amplitude, 4 to 9 per minute fluctuations in heart rate during alert waking. This pattern was most pronounced in poor candidates for anterior temporal lobe resection (2/19). The 4 to 9 per minute heart-rate variability pattern may emerge following diffuse, extratemporal, or bilateral mesial temporal damage, which interferes with descending forebrain influences on cardiovascular regulation.
Frysinger
R C
RC
Department of Anatomy and Cell Biology, UCLA School of Medicine 90024-1763.
Engel
J
J
Harper
R M
RM
D000293:Adolescent; D000328:Adult; D015716:Electrocardiography, Ambulatory; D004569:Electroencephalography; D017029:Epilepsy, Complex Partial / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D012016:Reference Values; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome