[Microcirculatory hemostasis in children with insulin-dependent diabetes mellitus].
Study of microcirculatory hemostasis in children with insulin-dependent diabetes mellitus helped the authors to make new conclusions on metabolic changes underlying blood coagulation cellular factors, namely, the red cell and platelet levels. Fifty children aged 7 to 15, suffering from type I condition, were examined. Ten of these were examined during the compensation stage, 23 during decompensation without ketosis, and 17 with ketoacidosis. Twelve age-matched healthy children were controls. Noticeable disorders in the microcirculatory hemostasis system were revealed in diabetic children, these changes manifesting by changed functional activities of red cells and platelets. Reduced share of platelet deaggregation, increased red cell aggregation time, reduced thromboelastogram chronometric constant and reduction of its structural parameters may be considered as the early signs of these changes. The risk of microcirculatory hemostasis disturbances augments with the disease duration and progress.
Turkina
T I
TI
Marchenko
L F
LF
Savenkova
M S
MS
Sapelkina
L V
LV
D000293:Adolescent; D001778:Blood Coagulation Disorders / Q000209:etiology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D004903:Erythrocyte Aggregation / Q000502:physiology; D018056:Hemorheology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008833:Microcirculation / Q000502:physiology*; D010974:Platelet Aggregation / Q000502:physiology; D012307:Risk Factors; D013916:Thrombelastography