Translocation t(1;22) mimicking t(1;19) in a child with acute lymphoblastic leukemia as revealed by chromosome painting.
The karyotype of a boy with acute lymphoblastic leukemia (ALL) presenting with numerical and structural chromosome aberrations as determined by Giemsa-banding was further investigated using chromosome painting (CP). A translocation t(11;18)(q23;q21) was verified by this approach, and gain of chromosome 21 material due to a structural rearrangement was detected. Moreover, an unbalanced translocation of the long arm of chromosome 1, resembling the well known translocation t(1;19), was demonstrated to involve chromosome 22 instead of chromosome 19. Immunophenotyping of the leukemic blasts led to the diagnosis common ALL (CD19+, CD10+, clg-). Our case indicates that in ALL a translocation t(1;19) may be mimicked by other chromosomal rearrangements, and that CP may efficiently complement conventional cytogenetics in the exact characterization of the involved chromosomes.
Rieder
H
H
AG Tumorcytogenetik, Medizinische Universität, Lübeck, Germany.
Kolbus
U
U
Koop
U
U
Ludwig
W D
WD
Stollmann-Gibbels
B
B
Fonatsch
C
C
D002648:Child; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000502:physiology*; D002880:Chromosomes, Human, Pair 11 / Q000502:physiology; D002887:Chromosomes, Human, Pair 18 / Q000502:physiology; D002888:Chromosomes, Human, Pair 19 / Q000502:physiology*; D002891:Chromosomes, Human, Pair 21 / Q000502:physiology; D002892:Chromosomes, Human, Pair 22 / Q000502:physiology*; D015342:DNA Probes / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
D015342:DNA Probes