Determination of soluble interleukin-2 receptor in human seminal plasma.
Following lymphocyte activation a soluble form of TAC antigen is released. This soluble molecule (soluble interleukin-2 receptor, SIL-2R) seems to corresponds to a truncated extracellular part of the membrane-bound TAC antigen, being smaller than its cellular counterpart. SIL-2R was determined and correlated with PMN elastase levels in the seminal plasma of 79 adult men having different concentrations of PMN elastase (0-700 micrograms/L). The normal level of SIL-2R was detected in the seminal plasma of 15 healthy men. The mean +/- SEM was 101 +/- 29 units/mL. The relation between PMN elastase in human seminal plasma as an index for the state of lymphocyte activity and the sperm motility is also investigated.
Miska
W
W
Department of Dermatology and Andrology, University of Giessen, Germany.
Mahmoud
M
M
D000328:Adult; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D009504:Neutrophils / Q000201:enzymology; D010196:Pancreatic Elastase / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012016:Reference Values; D012661:Semen / Q000737:chemistry* / Q000201:enzymology; D012995:Solubility; D013081:Sperm Motility; D014570:Urologic Diseases / Q000201:enzymology / Q000276:immunology / Q000378:metabolism
D015375:Receptors, Interleukin-2; D010196:Pancreatic Elastase