Hypersensitivity pneumonitis and airways hyperreactivity induced by occupational exposure to penicillin.
A patient with penicillin-induced hyperreactive airways in association with hypersensitivity pneumonitis is described. Patch tests and intradermal tests to penicillin were positive. Bronchoalveolar lavage demonstrated a relative lymphocytosis and mild neutrophilia. Symptoms and physiologic abnormalities of pulmonary function and gas exchange resolved on cessation of exposure to penicillin.
de Hoyos
A
A
Division of Respirology and Occupational Lung Disease Clinic, Toronto Hospital, Canada.
Holness
D L
DL
Tarlo
S M
SM
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000139:chemically induced* / Q000473:pathology; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D004345:Drug Industry; D005260:Female; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology; D016273:Occupational Exposure; D010406:Penicillins / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000473:pathology; D012882:Skin Tests
D010406:Penicillins