Racemization of aspartic acid in the extracellular matrix proteins of primary and secondary dentin.
The accumulation with age of D-aspartic acid in primary and secondary human dentin was determined. In primary dentin, the plot of the D/L Asp ratio vs. age was found to fit first-order kinetics in accordance with the literature. But the secondary dentin behaved in an irregular manner and showed, in the great majority of cases, significantly increased D/L Asp ratios. Possible reasons for these findings, such as differences in protein composition and/or in the prevailing temperature, are discussed.
Saleh
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N
Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel.
Deutsch
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D
Gil-Av
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E
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D001224:Aspartic Acid / Q000032:analysis* / Q000737:chemistry* / Q000378:metabolism; D002648:Child; D002849:Chromatography, Gas; D003804:Dentin / Q000737:chemistry* / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D013237:Stereoisomerism
D016326:Extracellular Matrix Proteins; D001224:Aspartic Acid