title: Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents.
authors.affiliation: Department of Medicine, University of Chicago Pritzker School of Medicine, Ill.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ratain
authors.forename: R
authors.initials: R
authors.lastname: Mick
authors.forename: R L
authors.initials: RL
authors.lastname: Schilsky
authors.forename: M
authors.initials: M
authors.lastname: Siegler
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic / Q000592:standards*; D017322:Clinical Trials, Phase II as Topic / Q000592:standards*; D032962:Consent Forms; D030881:Disclosure; D004992:Ethics, Medical; D006801:Humans; D007258:Informed Consent; D033281:Nontherapeutic Human Experimentation; D018579:Patient Selection; D026684:Personal Autonomy; D012107:Research Design / Q000592:standards*; D035842:Research Subjects; D018570:Risk Assessment; D013223:Statistics as Topic; D036302:Therapeutic Human Experimentation; D014481:United States
chemical_list: D000970:Antineoplastic Agents