title: Application of maximum likelihood statistics for the population and family studies of inheritance of the chimpanzee R-C-E-F and V-A-B-D blood groups.
abstract: Maximum likelihood statistics were applied to the analysis of serological data to confirm the originally proposed genetic models of the chimpanzee R-C-E-F and V-A-B-D systems. Five hundred ninety-nine chimpanzees, including 81 parents of 114 offspring, were tested for R-C-E-F, and 60 parents of 80 offspring were tested for V-A-B-D blood groups. An estimation-maximization procedure was used to obtain maximum likelihood estimates and support intervals of the haplotype frequencies. For each haplotype, the null hypothesis of nonexistence was evaluated. The frequencies obtained by this method do not differ significantly from those calculated by the square root formula, but put these estimates on a statistically more rigorous footing.
authors.affiliation: Centre Régional de Transfusion Sanguine, CHU Purpan, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Blancher
authors.forename: J
authors.initials: J
authors.lastname: Clayton
authors.forename: W W
authors.initials: WW
authors.lastname: Socha
authors.forename: J
authors.initials: J
authors.lastname: Ruffié
mesh_terms: D000818:Animals; D001789:Blood Group Antigens / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006239:Haplotypes; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D002679:Pan troglodytes / Q000097:blood* / Q000235:genetics*
chemical_list: D001789:Blood Group Antigens