Cytokine production of peripheral blood mononuclear cells in a dermatophytosis patient in response to stimulation with trichophytin.
Interferon-gamma (IFN-gamma), interleukin 2 (IL-2) and granulocyte/macrophage colony-stimulating factor (GM-CSF) were detected in the culture supernatant after 72 hours incubation with trichophytin in the peripheral blood mononuclear cells (PBMC) obtained from a patient who had a dermatophyte infection. These findings indicate that this patient has peripheral T-lymphocytes that produced IFN-gamma, IL-2 and GM-CSF, which may play roles in the development of delayed-type hypersensitivity (DTH) reaction in the skin.
Koga
T
T
Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ishizaki
H
H
Matsumoto
T
T
Hori
Y
Y
D016207:Cytokines / Q000096:biosynthesis*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006119:Groin; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D016898:Interferon-alpha / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014005:Tinea / Q000276:immunology* / Q000378:metabolism; D014248:Trichophytin / Q000494:pharmacology*
D016207:Cytokines; D016898:Interferon-alpha; D007376:Interleukin-2; D014248:Trichophytin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor