Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.
Getman
D P
DP
Monsanto Corporate Research, Medicinal Chemistry Department, St. Louis, Missouri 63167.
DeCrescenzo
G A
GA
Heintz
R M
RM
Reed
K L
KL
Talley
J J
JJ
Bryant
M L
ML
Clare
M
M
Houseman
K A
KA
Marr
J J
JJ
Mueller
R A
RA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006918:Hydroxyurea / Q000031:analogs & derivatives*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D014508:Urea; C079293:SC 52151; D006918:Hydroxyurea