Cloning and characterization of human TNF alpha promoter region.
We report the sequence of a 1.2-kb human tumor necrosis factor alpha (TNF alpha) promoter region, which was cloned using PCR. The sequence has several variations from two previous reports and exhibits many potential DNA-binding sites specific to mammalian gene regulatory proteins inducible by lipopolysaccharides.
Takashiba
S
S
Department of Periodontology, Eastman Dental Center, Rochester, NY 14620.
Shapira
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Amar
S
S
Van Dyke
T E
TE
D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D004247:DNA