Posttransplant cutaneous lymphoma.
BACKGROUND
Posttransplant lymphoma is closely associated with Epstein-Barr virus (EBV) infection and appears to have a predilection for extranodal sites. We describe four cases of primary cutaneous posttransplant lymphoma.


OBJECTIVE
Our aim was to determine cell lineage and any possible association with EBV in each case of cutaneous lymphoma.


METHODS
Tumor tissue was examined by light microscopy, immunohistochemistry, nonisotopic in situ hybridization and polymerase chain reaction.


RESULTS
The data were consistent with a diagnosis of EBV-associated cutaneous B-cell lymphoma in three cases and cutaneous T-cell lymphoma not associated with EBV in one case. No patient with B-cell lymphoma had extracutaneous involvement during a mean follow-up of 3.9 years. The patient with cutaneous T-cell lymphoma died of cerebral involvement 9 months after initial presentation.


CONCLUSIONS
These data suggest a possible role for EBV infection in the origin of cutaneous B-cell lymphoma in immunosuppressed patients.
McGregor
J M
JM
Department of Dermatology, Guy's Hospital, London, UK.
Yu
C C
CC
Lu
Q L
QL
Cotter
F E
FE
Levison
D A
DA
MacDonald
D M
DM
D000368:Aged; D001483:Base Sequence; D001706:Biopsy; D004273:DNA, Neoplasm / Q000032:analysis; D005500:Follow-Up Studies; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006566:Herpesviridae Infections / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012867:Skin / Q000473:pathology; D014412:Tumor Virus Infections / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000473:pathology
D004273:DNA, Neoplasm