title: [Patho-morphological changes in the brain after severe burns].
abstract: This paper reports the dynamic patho-morphological changes of brain in rats within one month after severe extensive burn (30% TBSA, II degrees-III degrees) by light microscope, electron microscope and histochemistry. The brain tissues exhibited conspicuous and consistent morphological changes. They were characterized by: (1) swelling of endothelial cells associated with increase in number of pinocytotic vesicles, tubular structure, formation of endothelial gap; (2) degeneration, necrosis, and swelling, decreased or disappearance of organelle in neuron and neuroglia cells; (3) perivascular neuroglia cuffs; (4) neuronophagiod phenomenon. The lesions appeared at 6 hr postburn, and it became more marked with elapse of time and became prominent at 3d postburn. Most of the lesions were mild and disappeared at 30d postburn. The significance and pathogenesis of the main lesions were discussed.
authors.affiliation: Department of Pathology, Third Military Medical College, Chongqing.
authors.forename: Y P
authors.initials: YP
authors.lastname: Li
mesh_terms: D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D002056:Burns / Q000473:pathology*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar