[Radionuclide studies of atherosclerosis].
New Tc-99m-labeled brain perfusion imaging agents, such as Tc-99m-HMPAO, and Tc-99m-ECD, are developed and expected to improve the clinical study of cerebral perfusion disturbance due to arteriosclerosis. They enable us better images than I-123-IMP and more accurate diagnosis. Similarly, in the field of cardiovascular nuclear medicine, new Tc-99m-labeled compounds, Tc-99m-MIBI, Teboroxime and Tetrofosmin are available. Furthermore, I-123-MIBG, a tracer taken up in presynaptic adrenergic vesicles, and I-123-BMIPP, a new agent developed for the evaluation myocardial fatty acid metabolism, will mark a new epoch in the study of coronary sclerosis. In order to image atherosclerosis directly, In-111-polyclonal immunoglobulin G, Tc-99m-low density lipoprotein etc., are under investigation.
Machida
K
K
Department of Radiology, Saitama Medical Center, Saitama Medical School.
Honda
N
N
Mamiya
T
T
Takahashi
T
T
Kamano
T
T
Inoue
Y
Y
Kashimada
A
A
Osada
H
H
D000662:Amphetamines; D002560:Cerebrovascular Circulation; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007457:Iodine Radioisotopes; D020367:Iofetamine; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D000662:Amphetamines; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D013794:Thallium Radioisotopes; D019690:Technetium Tc 99m Exametazime; D020367:Iofetamine