Comparative mapping of the Grpr locus on the X chromosomes of man and mouse.
The gastrin-releasing peptide receptor has been previously cloned from both humans and mice. We have mapped the mouse gastrin-releasing peptide receptor (Grpr) locus using a polymorphic CAn repeat located in the 5' untranslated region of the gene and a Mus spretus/Mus musculus interspecific backcross. The Grpr locus mapped between the Pdha-1 and Amg loci on the mouse X chromosome. Studies in man indicate that GRPR maps to the Xp21.2-p22.3 region of the human X chromosome and not to the Xp11-q11 interval as previously reported. The assignment of the GRPR locus to the distal Xp region is supported by the comparative map position in the mouse.
Maslen
G L
GL
MRC Radiobiology Unit, Chilton, Didcot, Oxforshire, United Kingdom.
Boyd
Y
Y
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005796:Genes; D006801:Humans; D006824:Hybridization, Genetic; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018004:Receptors, Bombesin / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D013045:Species Specificity; D014960:X Chromosome
D018004:Receptors, Bombesin