Prevention of carcinogenicity of anticancer drugs by metallothionein induction.
We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.
Satoh
M
M
Department of Public Health and Environmental Medicine, Jikei University School of Medicine, Tokyo, Japan.
Kondo
Y
Y
Mita
M
M
Nakagawa
I
I
Naganuma
A
A
Imura
N
N
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001729:Bismuth / Q000627:therapeutic use*; D002273:Carcinogens / Q000633:toxicity*; D002712:Chlorides / Q000627:therapeutic use*; D002945:Cisplatin / Q000633:toxicity*; D005260:Female; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008558:Melphalan / Q000633:toxicity*; D008668:Metallothionein / Q000096:biosynthesis*; D051379:Mice; D008805:Mice, Inbred A; D009566:Nitrates / Q000627:therapeutic use*; D017967:Zinc Compounds / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D002712:Chlorides; D009566:Nitrates; D017967:Zinc Compounds; C065545:bismuth nitrate; C016837:zinc chloride; D008668:Metallothionein; D002945:Cisplatin; D008558:Melphalan; D001729:Bismuth