[The virulence, metacyclogenesis and respiratory enzymes of Leishmania isolated in culture from laboratory animals].
It has been shown that an increase of virulence of Leishmania major, L. tropica, L. braziliensis as a result of passing through animals and its decrease during the cultivation are accompanied by certain changes of biochemical characteristics of these promastigotes. In the former case the activity of NADP-H-diaphorase and peroxidase of promastigotes and their ability to be transformed into final (invasional) metacyclic forms increase and in the latter case these characteristics decrease. The level and duration of virulence in culture depend not only on absolute value of the above-mentioned characteristics but also on the graduality of their change. Metacyclogenesis and activity of oxidative enzymes are suggested to be the correlates of virulence of various Leishmania species.
Nasyrov
F Sh
FSh
Nasyrova
R M
RM
Kallinikova
V D
VD
Saf'ianova
V M
VM
D000818:Animals; D000830:Animals, Laboratory / Q000469:parasitology*; D006224:Cricetinae; D006801:Humans; D007892:Leishmania braziliensis / Q000201:enzymology / Q000254:growth & development / Q000472:pathogenicity*; D018320:Leishmania major / Q000201:enzymology / Q000254:growth & development / Q000472:pathogenicity*; D007895:Leishmania tropica / Q000201:enzymology / Q000254:growth & development / Q000472:pathogenicity*; D051379:Mice; D009024:Morphogenesis; D010088:Oxidoreductases / Q000378:metabolism*; D012692:Serial Passage; D014774:Virulence
D010088:Oxidoreductases