Intraocular endometrium in the rabbit as a model for endometriosis.
The model described suggests that endometrium can be successfully transplanted to the rabbit eye and observed through a slit lamp for morphological changes such as vascularization. Sampling of aqueous humor in volumes adequate for biochemical measurements have been demonstrated. Autografts of rabbit endometrium survived for up to 181 days. Although xenografts of human endometrial and endometriotic tissue demonstrate some adherence and vascularization, there is indication of immune rejection by day 7. Other treatment regimens will be explored with the objective of prolonging the graft survival time.
Rock
J A
JA
Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Prendergast
R A
RA
Bobbie
D
D
Green
W R
WR
Parmley
T H
TH
Dubin
N H
NH
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001808:Blood Vessels / Q000473:pathology; D004195:Disease Models, Animal; D004715:Endometriosis / Q000473:pathology*; D004717:Endometrium / Q000098:blood supply / Q000637:transplantation*; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D009799:Ocular Physiological Phenomena; D011817:Rabbits; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous
D004958:Estradiol