Apparent Greig cephalopolysyndactyly and sinus node disease.
We present the clinical findings and follow-up data from birth to 10.5 years in a boy with Greig cephalopolysyndactyly who, in addition, presents sinus node disease ("sick sinus syndrome"). The significance of the concurrence of Greig cephalopolysyndactyly syndrome, an autosomal dominant condition mapped at 7p13, and sinus node disease is discussed.
Fryns
J P
JP
Center for Human Genetics, University Hospital, Gasthuisberg, Leuven, Belgium.
De Waele
P
P
Van der Hauwaert
L
L
Van den Berghe
H
H
D000015:Abnormalities, Multiple / Q000235:genetics*; D001842:Bone and Bones / Q000002:abnormalities*; D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002897:Chromosomes, Human, Pair 7; D005147:Facial Bones / Q000002:abnormalities; D005532:Foot Deformities, Congenital / Q000235:genetics; D006228:Hand Deformities, Congenital / Q000235:genetics; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D008297:Male; D012849:Sinoatrial Node; D012886:Skull / Q000002:abnormalities; D013577:Syndrome