Primate genes for glycophorins carrying MN blood group antigens.
Glycophorin A, B, and E genes were derived from a common ancestral gene and this gene family appeared during primate evolution, probably between orangutan and gorilla divergences. Based on the study of genomic structures of these human glycophorins and the genetic and immunological study of primate glycophorins, we hypothesize that chimpanzee and gorilla glycophorin B could possess a longer extracellular region and carry a stronger N blood group antigenicity compared with that of the human.
Kudo
S
S
La Jolla Cancer Research Foundation, Cancer Research Center, CA 92037.
Onda
M
M
Rearden
A
A
Fukuda
M
M
D000818:Animals; D005075:Biological Evolution; D006021:Glycophorins / Q000737:chemistry / Q000235:genetics*; D006071:Gorilla gorilla / Q000097:blood / Q000235:genetics / Q000276:immunology; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics* / Q000276:immunology*; D015394:Molecular Structure; D005810:Multigene Family; D002679:Pan troglodytes / Q000097:blood / Q000235:genetics / Q000276:immunology; D011323:Primates / Q000097:blood* / Q000235:genetics / Q000276:immunology; D015183:Restriction Mapping; D013045:Species Specificity
D006021:Glycophorins; D008951:MNSs Blood-Group System