[The value of antibiotic prophylaxis in transurethral resection of bladder tumors. Apropos of 61 cases].
In order to define the value of antibiotic prophylaxis, we conducted a prospective, randomised, double-blind, placebo-controlled study in 61 patients undergoing transurethral resection (TUR) of a bladder lesion suspected to be neoplastic. 32 patients received a single dose of 800 mg of pefloxacin at the time of anaesthetic induction and 29 patients received placebo. All patients had sterile preoperative urine and none had received any antibiotics during the fortnight preceding the operation. 3 patients in the pefloxacin group (9.4%) developed postoperative bacteriuria versus 7 in the placebo group (24.1%) (no statistically significant difference). No patient developed symptomatic urinary tract infection. We conclude that antibiotic prophylaxis is not indicated during TUR for bladder tumours.
Delavierre
D
D
Service d'Urologie, CHU Morvan, Brest.
Huiban
B
B
Fournier
G
G
Le Gall
G
G
Tande
D
D
Mangin
P
P
D000368:Aged; D001437:Bacteriuria / Q000517:prevention & control*; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000601:surgery; D003949:Diagnostic Techniques, Surgical; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015366:Pefloxacin / Q000627:therapeutic use*; D010919:Placebos; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D001745:Urinary Bladder Diseases / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*
D010919:Placebos; D015366:Pefloxacin