title: Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
abstract: Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a neuropathological feature of Alzheimer disease (AD). We examined the possibility that commonly observed variability in A beta deposition in late-onset AD might be related to apolipoprotein E genotype (APOE gene; the two most common alleles are 3 and 4), since APOE4 is a susceptibility gene for late-onset AD and apolipoprotein E interacts strongly with A beta in vitro. In an autopsy series of brains of late-onset AD patients, we found a strong association of APOE4 allele with increased vascular and plaque A beta deposits. Late-onset AD patients with one or two APOE4 alleles have a distinct neuropathological phenotype compared with patients homozygous for APOE3.
authors.affiliation: Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710.
authors.forename: D E
authors.initials: DE
authors.lastname: Schmechel
authors.forename: A M
authors.initials: AM
authors.lastname: Saunders
authors.forename: W J
authors.initials: WJ
authors.lastname: Strittmatter
authors.forename: B J
authors.initials: BJ
authors.lastname: Crain
authors.forename: C M
authors.initials: CM
authors.lastname: Hulette
authors.forename: S H
authors.initials: SH
authors.lastname: Joo
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: D
authors.initials: D
authors.lastname: Goldgaber
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001057:Apolipoproteins E / Q000235:genetics*; D016657:Cerebral Amyloid Angiopathy / Q000235:genetics / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism*; D004198:Disease Susceptibility; D006720:Homozygote; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology; D016900:Neurofilament Proteins / Q000378:metabolism; D011446:Prospective Studies; D012189:Retrospective Studies
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D016900:Neurofilament Proteins