title: Verapamil suppresses d-amphetamine-induced place preference conditioning.
abstract: The effect of pretreatment with (+/-)-verapamil (5, 10 or 15 mg/kg, i.p.) on place preference induced with d-amphetamine (1 mg/kg, i.p. 40 min after verapamil) was studied in male rats. Place preference conditioning was performed using two-compartment shuttle boxes and 8 alternating stimulant/saline sessions. Verapamil dose-dependently suppressed amphetamine-induced place preference. No significant changes in place preference were observed following 8 alternating verapamil (no stimulant)/saline sessions, irrespective of whether verapamil injections were paired with the originally less or the originally more preferred compartment. It appears that verapamil effectively suppresses the reinforcing properties of d-amphetamine in the paradigm used.
authors.affiliation: Skipper Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, School of Medicine 27599.
authors.forename: O
authors.initials: O
authors.lastname: Pucilowski
authors.forename: P L
authors.initials: PL
authors.lastname: Garges
authors.forename: A H
authors.initials: AH
authors.lastname: Rezvani
authors.forename: S
authors.initials: S
authors.lastname: Hutheson
authors.forename: D S
authors.initials: DS
authors.lastname: Janowsky
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil; D003913:Dextroamphetamine