title: Mediation by G proteins of signals that cause collapse of growth cones.
abstract: During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.
authors.affiliation: Developmental Biology Laboratory, Massachusetts General Hospital-East, Charlestown 02129.
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: S M
authors.initials: SM
authors.lastname: Strittmatter
authors.forename: T
authors.initials: T
authors.lastname: Vartanian
authors.forename: M C
authors.initials: MC
authors.lastname: Fishman
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D002642:Chick Embryo; D019204:GTP-Binding Proteins / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D009185:Myelin Proteins / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D009924:Organ Culture Techniques; D010455:Peptides; D037342:Pertussis Toxin; D015398:Signal Transduction; D010566:Virulence Factors, Bordetella / Q000494:pharmacology; D014862:Wasp Venoms / Q000494:pharmacology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009185:Myelin Proteins; D010455:Peptides; D010566:Virulence Factors, Bordetella; D014862:Wasp Venoms; C037500:mastoparan; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins