Bullous amyloidosis. Report of 3 cases and review of the literature.
We report 3 cases of bullous immunoglobulinic amyloidosis and review 25 published cases. In 2 of our patients, amyloid deposits were not detected with special staining, but by means of ultrastructural methods. Investigations of the skin lesions permitted the diagnosis of associated plasma cell dyscrasia in 2 patients. Unexplained bullous lesions should be investigated for amyloid deposits and the presence of monoclonal gammopathy by methods including electron microscopy and immunochemical analysis of serum and urine.
Robert
C
C
Clinique des Maladies Cutanées, Hôpital Saint-Louis, Paris, France.
Aractingi
S
S
Prost
C
C
Verola
O
O
Blanchet-Bardon
C
C
Blanc
F
F
Bagot
M
M
Dubertret
L
L
Fermand
J P
JP
D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology / Q000378:metabolism