Tumour necrosis factor-alpha alters the blood compartmentation of amino acids in the rat.
The work presented focuses on the importance of studying the distribution of blood amino acids in both the cellular and plasmatic fraction when performing studies concerning the effects of cytokines on amino acid metabolism. Tumour necrosis factor treatment resulted in important changes in blood amino acid compartmentation between plasma and red blood cells in rats. The animals showed a change in compartmentation with an increase in the concentration of most amino acids in the cellular fraction with the exception of phenylalanine, glutamate, aspartate and tyrosine.
Llovera
M
M
Departament de Bioquímica i Fisiologia, Universitat de Barcelona, Spain.
López-Soriano
F J
FJ
Argilés
J M
JM
D000596:Amino Acids / Q000097:blood* / Q000187:drug effects*; D000818:Animals; D001773:Blood Cells / Q000737:chemistry; D005260:Female; D007274:Injections, Intraperitoneal; D010949:Plasma / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000494:pharmacology*
D000596:Amino Acids; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha