title: Recent advances in the management of Fournier's gangrene: preliminary observations.
abstract: Twenty consecutive cases of Fournier's gangrene managed conservatively with systemic antibiotics and topical application of unprocessed honey (group A) were compared with 21 similar cases of Fournier's gangrene managed by the orthodox method (group B) during the same period. Group A received oral amoxicillin/clavulanic acid and metronidazole in addition to daily topical application of honey to the gangrenous scrotum, whereas group B underwent wound debridement, wound excision, secondary suturing, and in some cases scrotal plastic reconstruction in addition to receiving a mixture of systemic antibiotics dictated by culture and sensitivity results. The organisms cultured in both groups were similar. Even though the average duration of hospitalization was slightly longer in group A (4.5 weeks) as opposed to group B (4 weeks), topical application of honey showed distinct advantages over the orthodox method. Three deaths occurred in group B, whereas no deaths occurred in group A. The need for anesthesia and expensive surgical operation was obviated. Response to treatment and alleviation of morbidity were faster in group A. Honey may revolutionize the treatment of this dreadful disease by reducing morbidity and mortality.
authors.affiliation: University Department of Surgery, University Teaching Hospital, Calabar, Nigeria.
authors.forename: S E
authors.initials: SE
authors.lastname: Efem
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000382:microbiology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003646:Debridement; D005734:Gangrene; D006722:Honey; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012611:Scrotum / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D016038:Skin Transplantation; D013524:Surgical Flaps