Adafenoxate abolishes the amnesia induced by neonatal 6-hydroxydopamine treatment in rats.
The effect of neonatal 6-hydroxydopamine (6-OHDA) treatment on learning and memory and on the levels of biogenic monoamines in some brain structures, as well as the influence of the nootropic drug adafenoxate on 6-OHDA effect was studied in shuttle box and step down trained rats. In mature rats injected with 6-OHDA postnatal, learning and retention were impaired and the noradrenaline (NA) level in the frontal cortex and hippocampus was decreased. Adafenoxate abolished the amnestic effect of 6-OHDA and restored the NA level to normal in the above-mentioned brain structures. This finding suggests the important role of the noradrenergic neurotransmitter system in 6-OHDA-induced amnesia and the favorable effect of adafenoxate on learning and memory impaired by 6-OHDA.
Genkova-Papazova
M G
MG
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Stancheva
S L
SL
Alova
L G
LG
Lazarova-Bakarova
M B
MB
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001362:Avoidance Learning / Q000187:drug effects; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D003071:Cognition / Q000187:drug effects; D008297:Male; D002504:Meclofenoxate / Q000031:analogs & derivatives* / Q000494:pharmacology; D008569:Memory Disorders / Q000139:chemically induced; D009498:Neurotoxins; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D017208:Rats, Wistar
D001679:Biogenic Amines; D009498:Neurotoxins; D016627:Oxidopamine; C054061:adafenoxate; D002504:Meclofenoxate; D009638:Norepinephrine