title: Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492.
authors.forename: N
authors.initials: N
authors.lastname: Balasubramanian
authors.forename: D R
authors.initials: DR
authors.lastname: St Laurent
authors.forename: M E
authors.initials: ME
authors.lastname: Federici
authors.forename: N A
authors.initials: NA
authors.lastname: Meanwell
authors.forename: J J
authors.initials: JJ
authors.lastname: Wright
authors.forename: W A
authors.initials: WA
authors.lastname: Schumacher
authors.forename: S M
authors.initials: SM
authors.lastname: Seiler
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000494:pharmacology; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000991:Antithrombins / Q000138:chemical synthesis* / Q000494:pharmacology; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D008969:Molecular Sequence Data; D051381:Rats; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D000991:Antithrombins; D004151:Dipeptides; C079295:BMY 44621; D013917:Thrombin