title: Roles of leukotriene B4, prostaglandin E2, and cyclic AMP in Campylobacter jejuni-induced intestinal fluid secretion.
abstract: Infection of rabbit ileal loops with inflammatory Campylobacter jejuni strains caused elevation of cyclic AMP, prostaglandin E2, and leukotriene B4 levels in tissue and fluids. Incubation of cultured Caco-2 cells with loop fluids caused elevated cellular cyclic AMP levels, an effect which was inhibited by antiserum against prostaglandin E2.
authors.affiliation: Department of Genetics, University of Leicester, United Kingdom.
authors.forename: P H
authors.initials: PH
authors.lastname: Everest
authors.forename: A T
authors.initials: AT
authors.lastname: Cole
authors.forename: C J
authors.initials: CJ
authors.lastname: Hawkey
authors.forename: S
authors.initials: S
authors.lastname: Knutton
authors.forename: H
authors.initials: H
authors.lastname: Goossens
authors.forename: J P
authors.initials: JP
authors.lastname: Butzler
authors.forename: J M
authors.initials: JM
authors.lastname: Ketley
authors.forename: P H
authors.initials: PH
authors.lastname: Williams
mesh_terms: D000818:Animals; D002169:Campylobacter Infections / Q000378:metabolism* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000472:pathogenicity*; D002460:Cell Line; D000242:Cyclic AMP / Q000502:physiology*; D015232:Dinoprostone / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000382:microbiology; D007419:Intestinal Secretions / Q000378:metabolism*; D007975:Leukotriene B4 / Q000502:physiology*; D011817:Rabbits
chemical_list: D007975:Leukotriene B4; D000242:Cyclic AMP; D015232:Dinoprostone