Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs.
A randomized, double-blind, controlled study was performed with 18 arthritic dogs administered aspirin (25 mg/kg of body weight, PO, q 8 h) and excipient (control group) or aspirin and misoprostol (100 micrograms, PO, q 8 h). Dogs in the misoprostol (n = 10) and control (n = 8) groups were primarily compared by use of sequential gastroduodenoscopy, changes in PCV, and prevalence of clinical signs of gastrointestinal disturbance over a 14-day treatment period. The misoprostol/aspirin-treated group had significantly (P < 0.05) less gastroduodenal hemorrhage and ulceration and a significantly (P < 0.05) lower prevalence of vomiting than did the control group.
Murtaugh
R J
RJ
Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
Matz
M E
ME
Labato
M A
MA
Boudrieau
R J
RJ
D000818:Animals; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D004285:Dogs; D004311:Double-Blind Method; D004384:Duodenoscopy / Q000662:veterinary; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control / Q000662:veterinary; D005773:Gastroscopy / Q000662:veterinary; D008297:Male; D016595:Misoprostol / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy / Q000662:veterinary*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary
D016595:Misoprostol; D001241:Aspirin