Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme.
The regulatory enzyme, protein kinase C (PKC), is characterized by a family of related isozymes. Currently, nucleotide (nt) sequences for seven members of this family have been reported from the bovine, human and rat genomes. Only four of these seven PKC isoforms have been isolated in mouse: alpha, beta II, delta and epsilon. Here, we report the cDNA sequence encoding mouse PKC-gamma isolated from a C57BL/6 brain cDNA library. The mouse and rat PKC-gamma nt and deduced amino acid sequences share 97 and 100% identity, respectively.
Bowers
B J
BJ
Institute for Behavioral Genetics, University of Colorado, Boulder 80309.
Parham
C L
CL
Sikela
J M
JM
Wehner
J M
JM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000201:enzymology*; D007527:Isoenzymes / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D011493:Protein Kinase C / Q000235:genetics*
D007527:Isoenzymes; D011493:Protein Kinase C