Status of liposomes as MR contrast agents.
Recent work on the development of liposomal magnetic resonance (MR) contrast agents has yielded structures with higher overall relaxivity than that of other nanoparticles of similar diameter. Liposomes incorporating membrane-bound complexes of manganase ("memsomes") produce greater hepatic enhancement per micromole of metal ion than either ferrite particles or paramagnetic chelates. Memsomes also hold promise for targeting of sites outside the liver. Work is in progress to take these agents into clinical trials.
Unger
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Department of Radiology, University of Arizona Health Sciences Center, Tucson 85724.
Shen
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Fritz
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D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D006801:Humans; D008081:Liposomes; D008099:Liver / Q000033:anatomy & histology*; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008345:Manganese
D003287:Contrast Media; D008081:Liposomes; D008345:Manganese; D005682:Gadolinium