Chronic exposure to lead attenuates cocaine-induced behavioral activation.
Adult, male rats were exposed to a diet containing 500 ppm (0.05%) lead for 105 days before testing for cocaine-related changes in activity using a Digiscan activity system. Behavioral testing occurred on 6 successive test days. Activity was recorded for 20 min prior to and 40 min after IP injections of either 10, 20, or 40 mg/kg cocaine HCl, with saline injections on the day preceding each drug test day. Cocaine-induced behavioral activation was evident in control diet animals for all three doses (10, 20, and 40 mg/kg). While 10 mg/kg cocaine HCl did not produce behavioral activation in lead-treated animals, both 20 and 40 mg/kg did result in increased activity comparable to that observed in control counterparts.
Grover
C A
CA
Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University, College Station 77843-1114.
Nation
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JR
Bratton
G R
GR
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004032:Diet; D004435:Eating / Q000187:drug effects; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D007854:Lead; D003042:Cocaine