Sex preselection through albumin separation of sperm.
OBJECTIVE
To determine if passage of sperm through columns of liquid albumin before their use in artificial insemination could affect the sex ratio at birth.


METHODS
Sperm were isolated by layering over columns of liquid albumin. The isolated fractions were inseminated into the uterus on the presumptive day of ovulation.


METHODS
Patients were treated in 65 clinical practices (Sperm Centers) located both in this country (57) and abroad (8).


METHODS
Individuals were self-selected by their desire to have a child of a specified sex.


METHODS
The sex of offspring resulting from the insemination of isolated sperm.


RESULTS
Insemination with sperm isolated to enhance male sex preselection produced 71% and 76% males depending on the technique. Use of isolated sperm in women who were taking clomiphene citrate was associated with a 69% birth of females.


CONCLUSIONS
Separation of sperm on columns of liquid albumin can affect the sex ratio at birth.
Beernink
F J
FJ
East Bay Fertility Obstetrics-Gynecology Medical Group, Berkeley, California 94705.
Dmowski
W P
WP
Ericsson
R J
RJ
D002469:Cell Separation / Q000379:methods*; D005260:Female; D005306:Fertilization; D006801:Humans; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012709:Serum Albumin; D012743:Sex Preselection; D013081:Sperm Motility; D013094:Spermatozoa
D012709:Serum Albumin