title: [Effect of ligustrazine controlled release capsule on hemorrheology in patients with cor pulmonale].
abstract: Before and after oral administration of Ligustrazine controlled release capsule, changes of hemorrheology and TXA2/PGI2 were evaluated in 16 patients with advanced cor pulmonale. It was shown that the effects of decreasing whole blood and plasma viscosity and lowering hematocrit and fibrinogen level were noted after one course of treatment with this medication. It is suggests that anticoagulant, effect of Ligustrazine is probably related to its role of improving inbalance between TXA2 and PGI2 in patients with cor pulmonale.
authors.affiliation: Respiratory Disease Research Institute, Tongji Hospital, Tongji Medical University, Wuhan.
authors.forename: W
authors.initials: W
authors.lastname: Peng
authors.forename: S F
authors.initials: SF
authors.lastname: Duan
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects*; D003692:Delayed-Action Preparations; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000097:blood / Q000188:drug therapy*; D011719:Pyrazines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D003692:Delayed-Action Preparations; D011719:Pyrazines; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D005340:Fibrinogen; C017953:tetramethylpyrazine