title: Angiotensin-converting enzyme activator from purified human neutrophils.
abstract: An endogenous ACE activator has been revealed. Neutrophil-enriched human leucocyte preparations released in isotonic media a relatively thermostable factor, capable of increasing the angiotensin-converting enzyme activity 1.6-2.0-fold. Activator would not pass through a 30 kDa cutoff membrane. Data on the presence of the activator in vivo were obtained in studies of protein-free serum fractions of patients with a hereditary CI-esterase inhibitor deficiency. It was suggested that the neutrophil-released ACE activator could have a role in the modulation of the inflammatory response.
authors.affiliation: Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences, Moscow.
authors.lastname: Elisseeva YuE
authors.forename: L V
authors.initials: LV
authors.lastname: Pavlikhina
authors.forename: T V
authors.initials: TV
authors.lastname: Shavghulidze
authors.forename: E
authors.initials: E
authors.lastname: Messina
authors.forename: A
authors.initials: A
authors.lastname: Giacomello
authors.forename: C
authors.initials: C
authors.lastname: Salerno
authors.forename: R
authors.initials: R
authors.lastname: Perricone
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007668:Kidney / Q000201:enzymology; D008297:Male; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000737:chemistry*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D007703:Peptidyl-Dipeptidase A