title: Malignant fibrous histiocytoma arising in a previous site of fracture and osteomyelitis.
abstract: Malignant fibrous histiocytomas (MFH) are known to arise in benign pre-existing conditions. We present here a case where MFH occurred more than 40 years after a fracture and infection. The diagnosis was established only after repeated clinical and histopathologic examinations. DNA flow cytometric and chromosomal analyses were also done.
authors.affiliation: Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Heliö
authors.forename: A
authors.initials: A
authors.lastname: Kivioja
authors.forename: E O
authors.initials: EO
authors.lastname: Karaharju
authors.forename: I
authors.initials: I
authors.lastname: Elomaa
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
mesh_terms: D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005264:Femoral Fractures / Q000150:complications / Q000601:surgery; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics*; D005598:Fractures, Spontaneous / Q000209:etiology; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications; D011183:Postoperative Complications; D013997:Time Factors; D014178:Translocation, Genetic
chemical_list: D004273:DNA, Neoplasm