title: Antibody response after influenza immunization with various vaccine doses: a double-blind, placebo-controlled, multi-centre, dose-response study in elderly nursing-home residents and young volunteers.
abstract: The dose effect (0, 10, 20 and 60 micrograms) of influenza subunit vaccine on the antibody response was investigated in nursing-home residents and young controls. The vaccine antigens were: A/Taiwan/1/86 (H1N1), A/Sichuan/2/87 (H3N2) and B/Beijing/1/87. For the influenza B antigen, the post-GMT and the 'percentage protective titre' increased significantly both in the young controls and nursing-home residents. No dose effect was observed for the A/Taiwan, and a minor dose effect for A/Sichuan. All vaccine doses were well tolerated by both groups. We conclude from our data that higher vaccine doses may result in a better antibody response against some antigens but not against others. Therefore, in general, increasing the vaccine dose is no adequate method to improve the antibody response.
authors.affiliation: Department of Virology, Erasmus University Rotterdam, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Palache
authors.forename: W E
authors.initials: WE
authors.lastname: Beyer
authors.forename: M J
authors.initials: MJ
authors.lastname: Sprenger
authors.forename: N
authors.initials: N
authors.lastname: Masurel
authors.forename: S
authors.initials: S
authors.lastname: de Jonge
authors.forename: A
authors.initials: A
authors.lastname: Vardy
authors.forename: B
authors.initials: B
authors.lastname: Charpentier
authors.forename: J
authors.initials: J
authors.lastname: Noury
authors.forename: W C
authors.initials: WC
authors.lastname: van Beek
authors.forename: R J
authors.initials: RJ
authors.lastname: Borst
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral / Q000008:administration & dosage; D004306:Dose-Response Relationship, Immunologic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines