Roles of leukotriene B4, prostaglandin E2, and cyclic AMP in Campylobacter jejuni-induced intestinal fluid secretion.
Infection of rabbit ileal loops with inflammatory Campylobacter jejuni strains caused elevation of cyclic AMP, prostaglandin E2, and leukotriene B4 levels in tissue and fluids. Incubation of cultured Caco-2 cells with loop fluids caused elevated cellular cyclic AMP levels, an effect which was inhibited by antiserum against prostaglandin E2.
Everest
P H
PH
Department of Genetics, University of Leicester, United Kingdom.
Cole
A T
AT
Hawkey
C J
CJ
Knutton
S
S
Goossens
H
H
Butzler
J P
JP
Ketley
J M
JM
Williams
P H
PH
D000818:Animals; D002169:Campylobacter Infections / Q000378:metabolism* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000472:pathogenicity*; D002460:Cell Line; D000242:Cyclic AMP / Q000502:physiology*; D015232:Dinoprostone / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000382:microbiology; D007419:Intestinal Secretions / Q000378:metabolism*; D007975:Leukotriene B4 / Q000502:physiology*; D011817:Rabbits
D007975:Leukotriene B4; D000242:Cyclic AMP; D015232:Dinoprostone