title: Osteoconduction exerted by methylpyrrolidinone chitosan used in dental surgery.
abstract: Surgical wounds from wisdom tooth avulsions were medicated with freeze-dried methylpyrrolidinone chitosan, a gel-forming resorbable biopolymer obtained from crab chitosan by chemical modification. Methylpyrrolidinone chitosan promoted osteoconduction and the space left after avulsion was filled with newly formed bone tissue, which conferred desirable mechanical and physiological characteristics to the healed would site. Morphological evidence obtained from biopsies confirmed the radiographic data. Methylpyrrolidinone chitosan was progressively depolymerized by lysozyme and was no longer detected 6 months after surgery. None of the 10 patients reported adverse effects over one year of observation.
authors.affiliation: Faculty of Medicine, University of Ancona, Italy.
authors.forename: R A
authors.initials: RA
authors.lastname: Muzzarelli
authors.forename: G
authors.initials: G
authors.lastname: Biagini
authors.forename: M
authors.initials: M
authors.lastname: Bellardini
authors.forename: L
authors.initials: L
authors.lastname: Simonelli
authors.forename: C
authors.initials: C
authors.lastname: Castaldini
authors.forename: G
authors.initials: G
authors.lastname: Fratto
mesh_terms: D001861:Bone Regeneration; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D003764:Dental Materials; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008964:Molar, Third / Q000601:surgery; D011760:Pyrrolidinones; D014084:Tooth Avulsion / Q000473:pathology / Q000601:surgery
chemical_list: D003764:Dental Materials; D011760:Pyrrolidinones; C085060:methylpyrrolidinone chitosan; D002686:Chitin; D048271:Chitosan; C038678:N-methylpyrrolidone