Dendritic epidermal T cells: lessons from mice for humans.
Dendritic epidermal T cells (DETC) in mice form part of a primitive system of epithelial-resident T cells characterized by the expression of gamma delta T-cell receptors (TCR). Critical attributes that characterize DETC include their highly restricted T-cell receptor gene utilization, proliferation and maturation within epidermis, a capacity to kill relevant skin-derived tumor targets, and the ability to modulate immune responses that are initiated and expressed in skin. Contemporary knowledge suggests that DETC and the related skin-directed gamma delta T cells found in humans play important roles in maintaining the immunologic integrity of skin.
Bergstresser
P R
PR
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235.
Cruz
P D
PD
Takashima
A
A
D000818:Animals; D002460:Cell Line; D003713:Dendritic Cells / Q000378:metabolism / Q000502:physiology; D000078404:Epidermal Cells; D006801:Humans; D051379:Mice; D010641:Phenotype; D016692:Receptors, Antigen, T-Cell, gamma-delta; D012871:Skin Diseases / Q000209:etiology; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology
D016692:Receptors, Antigen, T-Cell, gamma-delta