Skin conductance reaction (SCR)-habituation test, an elementary model of anxiety as a tool to assess anxiogenic activities of some drugs.
1. The SCR-habituation test, used as a tool to detect an anxiolytic activity, is applied to the study of several anxiogenic drugs. This test is based on the measure of the SCR-extinction time (i.e. habituation) got by the way of an iterative photostimulus. 2. 8 anxiogenic compounds are tested. They delay significantly and quantitatively the SCR habituation. 3. Specificity, sensitivity and quantifying values of the test are considered in order to propose the use of the SCR-habituation test in the investigation of putative anxiogenic compounds.
Quermonne
M A
MA
Department of Pharmacology, University of Caen, France.
Nammathao
B
B
Louchahi-Raoul
J
J
Marcy
R
R
D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D010775:Photic Stimulation; D012149:Restraint, Physical