title: Lipofuscin, the age pigment.
abstract: Lipofuscin is the fluorescent mixture of compounds that accumulates increasingly with age in human tissues, including the pigment epithelium of the retina. A substantial component of lipofuscin has been identified in the retina as N-retinylidene-N-retinylethanolamine. This compound presumably is derived from the reaction of retinaldehyde with the membrane lipid phosphatidylethanolamine.
authors.affiliation: Department of Nutritional Sciences, University of California, Berkeley 94720.
authors.forename: G
authors.initials: G
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D006801:Humans; D008062:Lipofuscin / Q000737:chemistry / Q000378:metabolism*; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D010858:Pigmentation / Q000502:physiology*; D014811:Vitamin E Deficiency / Q000378:metabolism
chemical_list: D008062:Lipofuscin