title: Promoter resurrection by activators--a minireview.
abstract: Frequently, in nature, defective promoters can be resurrected by activator proteins in response to cellular demands. The activators bind to nearby DNA sites for action. Various protein-protein and DNA-protein contacts involving activators, RNA polymerase, and different segments of DNA in and around a defective promoter form a DNA-multiprotein complex (cage) which enhances transcription.
authors.affiliation: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: S
authors.initials: S
authors.lastname: Adhya
authors.forename: M
authors.initials: M
authors.lastname: Gottesman
authors.forename: S
authors.initials: S
authors.lastname: Garges
authors.forename: A
authors.initials: A
authors.lastname: Oppenheim
mesh_terms: D004247:DNA / Q000737:chemistry; D009690:Nucleic Acid Conformation; D011401:Promoter Regions, Genetic; D012808:Sigma Factor / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D012808:Sigma Factor; D015534:Trans-Activators; D004247:DNA