[Specific IgE in the cord blood of infants from allergic parents].
We evaluated the cord blood level of specific IgE in newborn having first grade relatives affected by allergic disease. We aimed: a) to look for a significant threshold (if any) of sp. IgE predictive of atopy; b) to verify the clinical reliability of the CAP System by Pharmacia. 9 out of 60 patients with positive family history had sp. IgE > 0.35 KU/L; 7 out of these 9 children were symptomatic to a clinical follow-up at 18 months. Moreover 65% of children with positive history but no sp. IgE and 100% of patients with both a negative history and no sp. IgE were completely free of allergic symptoms in the same period. We conclude that a careful history and cord blood sp. IgE measurement might be of value in early diagnosis of atopy.
Dall'Agnola
A
A
Clinica Pediatrica, Verona, Italia.
Gamba
C
C
Boccagni
P
P
Padovani
G
G
Caputo
M
M
D000918:Antibody Specificity; D005069:Evaluation Studies as Topic; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D015200:Fluoroimmunoassay; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000097:blood*; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male
D007073:Immunoglobulin E