Prevention of collagen induced arthritis in mice by deletion of T cell receptor V beta 8 bearing T cells with monoclonal antibodies.
Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes V beta 8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete V beta 6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 466B5 treated animals was not significantly different from controls. Thus, the V beta 8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.
Moder
K G
KG
Department of Rheumatology, Mayo Clinic, Rochester, MN 55905.
Luthra
H S
HS
Griffiths
M
M
David
C S
CS
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000517:prevention & control* / Q000628:therapy; D016923:Cell Death / Q000187:drug effects; D003094:Collagen; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D007167:Immunotherapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis*; D013601:T-Lymphocytes / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D016693:Receptors, Antigen, T-Cell, alpha-beta; D003094:Collagen