Detection of the testis determining factor in an XX man.
An XX male patient was examined for the presence of 25 loci on the Y chromosome. Only 2 loci, the proximal border of the pseudoautosomal region Y and the sex determining region Y, were detected in this patient. The other 23 loci, including the zinc finger protein Y, were absent. We presume that a crossing over between the X and Y chromosomes occurred at the region proximal to the sex determining region Y but distal to the zinc finger protein Y during meiosis of the father.
Fukutani
K
K
Department of Urology, Asoka Hospital, Tokyo, Japan.
Kajiwara
T
T
Nagafuchi
S
S
Nakahori
Y
Y
Nakagome
Y
Y
D000293:Adolescent; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000032:analysis*; D006801:Humans; D007621:Karyotyping; D051741:Kruppel-Like Transcription Factors; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014157:Transcription Factors; D014960:X Chromosome / Q000737:chemistry*; D016335:Zinc Fingers
D015342:DNA Probes; D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human