title: Seizures associated with propofol anesthesia.
abstract: Propofol is a new, fast-acting intravenous (i.v.) anesthetic. Involuntary movements or epileptic seizures have occurred during or after propofol-induced anesthesia in approximately 50 reported cases; a third of the patients have had epilepsy. We report 5 patients with seizures in association with propofol anesthesia. A female epileptic patient developed severe status epilepticus; the other patients with short-lasting seizures had no previous epilepsy. Although propofol has been used in treatment of patients of status epilepticus, the risk of precipitation of epileptic seizures warrants consideration especially when planning anesthesia for epileptic patients.
authors.affiliation: Department of Neurology, University of Helsinki, Finland.
authors.forename: J P
authors.initials: JP
authors.lastname: Mäkelä
authors.forename: M
authors.initials: M
authors.lastname: Iivanainen
authors.forename: I P
authors.initials: IP
authors.lastname: Pieninkeroinen
authors.forename: O
authors.initials: O
authors.lastname: Waltimo
authors.forename: M
authors.initials: M
authors.lastname: Lahdensuu
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000150:complications; D005260:Female; D006801:Humans; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced*; D013226:Status Epilepticus / Q000139:chemically induced
chemical_list: D015742:Propofol