Dapsone poisoning.
Two cases of suicidal dapsone ingestion are reported. These patients presented with marked cyanosis and had significant methaemoglobinaemia on admission. One patient also had acute psychosis and haemolytic anaemia. Both patients responded to intravenous methylene blue therapy and nasal oxygen inhalation and recovered without any sequelae.
Sheela
A
A
Department of Medicine, St John's Medical College Hospital, Bangalore, India.
Thachil
R T
RT
Sridhar
C B
CB
D000328:Adult; D003131:Combined Modality Therapy; D003490:Cyanosis / Q000139:chemically induced* / Q000628:therapy; D003622:Dapsone / Q000506:poisoning*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007262:Infusions, Intravenous; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000628:therapy; D008751:Methylene Blue / Q000008:administration & dosage / Q000627:therapeutic use; D010102:Oxygen Inhalation Therapy; D011041:Poisoning / Q000628:therapy; D011605:Psychoses, Substance-Induced / Q000628:therapy; D013406:Suicide, Attempted
D003622:Dapsone; D008751:Methylene Blue