title: Multiple alignment of sequences on parallel computers.
abstract: A software package that allows one to carry out multiple alignment of protein and nucleic acid sequences of almost unlimited length and number of sequences is developed on C-DAC parallel computer--a transputer-based machine. The farming approach is used for data parallelization. The speed gains are almost linear when the number of transputers is increased from 4 to 64. The software is used to carry out multiple alignment of 100 sequences each of alpha-chain and beta-chain of hemoglobin and 83 cytochrome c sequences. The signature sequence of cytochrome c was found to be PGTKMXF. The single parameter, multiple alignment score, S, has been used to categorize proteins in different subfamilies and groups.
authors.affiliation: Center for Development of Advanced Computing, University of Poona, Pune, India.
authors.forename: S
authors.initials: S
authors.lastname: Date
authors.forename: R
authors.initials: R
authors.lastname: Kulkarni
authors.forename: B
authors.initials: B
authors.lastname: Kulkarni
authors.forename: U
authors.initials: U
authors.lastname: Kulkarni-Kale
authors.forename: A S
authors.initials: AS
authors.lastname: Kolaskar
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D003199:Computer Systems; D003574:Cytochrome c Group / Q000235:genetics; D005914:Globins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment / Q000379:methods* / Q000706:statistics & numerical data; D012984:Software
chemical_list: D003574:Cytochrome c Group; D005914:Globins