title: Neonatal Trichosporon beigelii infection: report of a cluster of cases in a neonatal intensive care unit.
abstract: Trichosporon beigelii, a ubiquitous yeast found in soil, causes superficial dermatologic infections in normal hosts and rare cases of disseminated disease among immunocompromised patients. Neonatal cases are exceptionally rare. We report a cluster of cases of T. beigelii infections in a tertiary care hospital in Rochester, NY, during May to July, 1991. Three cases occurred in very low birth weight premature infants (23 to 25 weeks of gestation), two of whom died. The organism was isolated from urine alone in one case, skin and blood in one case and blood, tracheal aspirate and central venous catheter tip in one case. In a fourth, full term infant with respiratory distress syndrome T. beigelii was grown only from a femoral central venous catheter tip with no clinical evidence of infection. An epidemiologic investigation was performed and the mode of transmission in this outbreak was not identified, although cross-infection was suspected in the initial two cases. Our isolates were inhibited but not killed by usually achievable concentrations of amphotericin B. T. beigelii may cause outbreaks of serious infection in neonatal intensive care units, especially among premature infants.
authors.affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642.
authors.forename: D J
authors.initials: DJ
authors.lastname: Fisher
authors.forename: C
authors.initials: C
authors.lastname: Christy
authors.forename: P
authors.initials: P
authors.lastname: Spafford
authors.forename: W M
authors.initials: WM
authors.lastname: Maniscalco
authors.forename: D J
authors.initials: DJ
authors.lastname: Hardy
authors.forename: P S
authors.initials: PS
authors.lastname: Graman
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000382:microbiology*; D007363:Intensive Care Units, Neonatal; D008297:Male; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D014250:Trichosporon / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents