Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults.
Based on previous cross-sectional findings, we hypothesized that weight loss could improve several hemostatic factors associated with cardiovascular disease. In a randomized controlled trial, moderately overweight men and women were assigned to one of four weight loss treatment groups or to a control group. Measurements of plasminogen activator inhibitor-1 (PAI-1) antigen, tissue-type plasminogen activator (t-PA) antigen, D-dimer antigen, factor VII activity, fibrinogen, and protein C antigens were made at baseline and after 6 months in 90 men and 88 women. Net treatment weight loss was 9.4 kg in men and 7.4 kg in women. There was no net change (p > 0.05) in D-dimer, fibrinogen, or protein C with weight loss. Significant (p < 0.05) decreases were observed in the combined treatment groups compared with the control group for mean PAI-1 (31% decline), t-PA antigen (24% decline), and factor VII (11% decline). Decreases in these hemostatic variables were correlated with the amount of weight lost and the degree that plasma triglycerides declined; these correlations were stronger in men than women. These findings suggest that weight loss can improve abnormalities in hemostatic factors associated with obesity.
Folsom
A R
AR
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015.
Qamhieh
H T
HT
Wing
R R
RR
Jeffery
R W
RW
Stinson
V L
VL
Kuller
L H
LH
Wu
K K
KK
D000328:Adult; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005167:Factor VII / Q000032:analysis*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood*; D015431:Weight Loss / Q000502:physiology*
D017395:Plasminogen Activator Inhibitor 1; D005167:Factor VII; D002784:Cholesterol; D010959:Tissue Plasminogen Activator