title: Long-term results of large-dose, single-session phenol injection sclerotherapy for hemorrhoids.
abstract: OBJECTIVE
  The aim of our study was to assess the medium to long-term outcome following single session large dose injection sclerotherapy for symptomatic hemorrhoids.
  
  
  METHODS
  One hundred eighty-nine patients (male = 106, female = 83, median age, 51; range, 20-85 years) were assessed following single-session, large-dose (3 x 5 ml) phenol injection therapy. The most frequent complaint was bleeding (100 percent).
  
  
  RESULTS
  At four-year follow-up, 53 patients (28.0 percent) were cured, 26 (13.7 percent) were improved, 35 (18.5 percent) remained unchanged, 59 (31.2 percent) deteriorated, and 16 (8.5 percent) required surgical intervention. Among the patients who were not cured, symptoms were minimal in 50 percent. Sclerotherapy was associated with a reduced incidence of bleeding (P < 0.05) but an increase in difficulty in perineal cleaning was observed (P < 0.05).
  
  
  CONCLUSIONS
  Large-dose, single-session sclerotherapy provides only short-term benefits in the majority of patients with symptomatic hemorrhoids.
authors.affiliation: University Department of Surgery, Royal Free Hospital and School of Medicine, London, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Santos
authors.forename: J R
authors.initials: JR
authors.lastname: Novell
authors.forename: G
authors.initials: G
authors.lastname: Khoury
authors.forename: M C
authors.initials: MC
authors.lastname: Winslet
authors.forename: A A
authors.initials: AA
authors.lastname: Lewis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006484:Hemorrhoids / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D019800:Phenol; D010636:Phenols / Q000008:administration & dosage*; D012008:Recurrence; D015911:Sclerotherapy / Q000379:methods*; D013997:Time Factors
chemical_list: D010636:Phenols; D019800:Phenol