title: Progressive language dysfunction and lobar atrophy.
abstract: The patterns of language disorder associated with 'progressive aphasia' due to lobar atrophy were compared with the language dysfunction of patients with dementia of frontal lobe type (DFT). The progressive aphasias were characterised primarily by impairment at the structural levels of language: phonology, grammar and semantics, whereas DFT was associated primarily with spontaneity and loss of generative capability. However, there was overlap in language symptomatology, particularly with progression of disease. The findings lend support to the argument that progressive aphasia and DFT represent different clinical manifestations of a common pathology, and form part of the spectrum of lobar atrophies.
authors.affiliation: Department of Neurology, Manchester Royal Infirmary, Manchester, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Snowden
authors.forename: D
authors.initials: D
authors.lastname: Neary
mesh_terms: D000328:Adult; D000368:Aged; D001039:Aphasia, Broca / Q000473:pathology / Q000523:psychology; D001041:Aphasia, Wernicke / Q000473:pathology / Q000523:psychology; D001284:Atrophy; D003704:Dementia / Q000473:pathology / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007806:Language Disorders / Q000523:psychology*; D008297:Male; D008875:Middle Aged