title: Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
abstract: Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.
authors.affiliation: Center for the Study of Biological Markers of Malignancy, Regional General Hospital, Venice, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Dittadi
authors.forename: P M
authors.initials: PM
authors.lastname: Donisi
authors.forename: A
authors.initials: A
authors.lastname: Brazzale
authors.forename: L
authors.initials: L
authors.lastname: Cappellozza
authors.forename: G
authors.initials: G
authors.lastname: Bruscagnin
authors.forename: M
authors.initials: M
authors.lastname: Gion
mesh_terms: D000368:Aged; D001940:Breast / Q000648:ultrastructure*; D001943:Breast Neoplasms / Q000648:ultrastructure*; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D066246:ErbB Receptors