A further case of acute nonlymphocytic leukemia with tetrasomy 8.
In very rare patients tetrasomy of chromosome 8 is observed as the only karyotypic event. We present a 74-year-old man with acute monocytic leukemia (FAB M5) displaying 46,XY/48,XY, +8, +8 in unstimulated bone marrow cells. The patient died 2 weeks after diagnosis. Tetrasomy 8 appears to identify a subgroup of acute nonlymphocytic leukemia. It may indicate a poor prognosis.
Wullich
B
B
Institute of Human Genetics, University of the Saar, Germany.
Koch
B
B
Schwarz
M
M
Lindemann
U
U
Pfreundschuh
M
M
Zang
K D
KD
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D007962:Leukocytes / Q000473:pathology; D008297:Male