Measurement of whole temporal lobe and hippocampus for MR volumetry: normative data.
We measured the volumes of the entire length of temporal lobe and hippocampal formation from coronal images in 29 healthy young adults to take into account normal side-to-side variation. Although whole-brain, temporal lobe, and left hippocampal volumes were significantly smaller in women, normalizing measurements for the whole brain eliminated intersex temporal lobe and hippocampal differences. There was a weak but significant inverse correlation between age and normalized hippocampal, but not temporal lobe or whole-brain, volume. In contrast to previous studies, we found no significant side-to-side differences in the sizes of temporal lobes or hippocampi. When performing MR volumetry, it is important to include the entire length of the hippocampal formation.
Bhatia
S
S
Epilepsy Research Branch, National Institutes of Health, Bethesda, MD 20892.
Bookheimer
S Y
SY
Gaillard
W D
WD
Theodore
W H
WH
D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012016:Reference Values; D012737:Sex Factors; D013702:Temporal Lobe / Q000033:anatomy & histology*