title: Severe chickenpox after intranasal use of corticosteroids.
abstract: Two children were hospitalized for severe chickenpox after intranasal use of corticosteroids for chronic sinusitis. One had unusually extensive cutaneous disease with delayed progression of lesions, dehydration, and prolonged fever; the other had hemorrhagic cutaneous lesions, hepatitis, and pneumonitis. Both were treated with intravenous acyclovir infusion and recovered. Systemic or local immunosuppression after intranasal corticosteroid administration may have predisposed the children to severe varicella infection.
authors.affiliation: Department of Pediatrics (Infectious Diseases), University of Colorado School of Medicine, Denver.
authors.forename: M J
authors.initials: MJ
authors.lastname: Abzug
authors.forename: M F
authors.initials: MF
authors.lastname: Cotton
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000281:Administration, Intranasal; D000293:Adolescent; D001507:Beclomethasone / Q000008:administration & dosage* / Q000009:adverse effects; D002644:Chickenpox / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D016867:Immunocompromised Host; D008297:Male; D012852:Sinusitis / Q000188:drug therapy
chemical_list: D001507:Beclomethasone; D000212:Acyclovir