Repeated aspiration of ovarian follicles and early corpus luteum cysts in an in-vitro fertilization programme reduces the risk of ovarian hyperstimulation syndrome in high responders.
A retrospective analysis of ovarian hyperstimulation syndrome in high responders undergoing in-vitro fertilization (IVF) is presented. High responders were defined as having > 20 follicles and serum oestradiol > 3000 pg/ml after treatment with human menopausal gonadotrophin. Of the initial 30 IVF cycles in high responders, 23 developed a moderate-to-severe ovarian hyperstimulation syndrome (76.7%). Subsequently, 15 other IVF cycles in high responders were combined with a repeated aspiration of ovarian follicles and corpus luteum cysts just prior to embryo transfer. Only three patients (20%) developed a moderate ovarian hyperstimulation syndrome (P = 0.0004). We conclude that repeated follicular aspiration is safe and results in a significant reduction in the incidence and severity of this condition in high responders undergoing IVF.
Amit
A
A
In Vitro Fertilization/Embryo Transfer Unit, Tel Aviv Sourasky Medical Centre, Serlin Maternity Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Yaron
Y
Y
Yovel
I
I
Peyser
M R
MR
David
M P
MP
Botchan
A
A
Lessing
J B
JB
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D003338:Corpus Luteum / Q000601:surgery*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000601:surgery*; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects; D012307:Risk Factors; D013396:Suction
D006063:Chorionic Gonadotropin; D004958:Estradiol; D008596:Menotropins