title: Sulphonamide and dapsone residues in bovine milk following intramammary infusion.
abstract: The elimination into bovine milk of sulphonamides (sulphadimidine and sulphamethoxypyridazine) and dapsone following intramammary infusion was studied. Determination of sulphonamides and dapsone in milk was performed by a high performance liquid chromatographic method with UV detection. The limit of quantification was 0.01 microgram/ml. Withdrawal times were established considering the maximum residue limits fixed by the European Community (100 micrograms/kg for sulphonamides and 25 micrograms/kg for dapsone). The diffusion of residues into milk from a quarter infused by the intramammary route to the untreated quarters was also studied.
authors.affiliation: Ministère de l'Agriculture et de la Forêt, Centre National d'Etudes Vétérinaires et Alimentaires, Fougères, France.
authors.forename: B
authors.initials: B
authors.lastname: Roudaut
authors.forename: M
authors.initials: M
authors.lastname: Garnier
mesh_terms: D000818:Animals; D002417:Cattle; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D007263:Infusions, Parenteral; D008321:Mammary Glands, Animal; D008892:Milk / Q000737:chemistry*; D013418:Sulfamethazine / Q000008:administration & dosage / Q000032:analysis*; D013421:Sulfamethoxypyridazine / Q000008:administration & dosage / Q000032:analysis*
chemical_list: D013418:Sulfamethazine; D013421:Sulfamethoxypyridazine