Neurotropism of mouse-adapted haemagglutinating encephalomyelitis virus.
The propagation of a mouse-adapted strain (67N) of haemagglutinating encephalomyelitis virus in infected mice and murine cells was examined by viral re-isolation and immunostaining. Viral propagation was strictly limited to the neurons and to an established line of neuroblastoma cells in in-vivo and in-vitro experiments. These results provide adequate evidence that this virus is neurotropic.
Yagami
K
K
Laboratory Animal Research Center, University of Tsukuba, Ibaraki, Japan.
Izumi
Y
Y
Kajiwara
N
N
Sugiyama
F
F
Sugiyama
Y
Y
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000382:microbiology; D002478:Cells, Cultured; D017934:Coronavirus / Q000302:isolation & purification / Q000502:physiology*; D018352:Coronavirus Infections / Q000473:pathology / Q000503:physiopathology; D005347:Fibroblasts / Q000166:cytology / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D009447:Neuroblastoma / Q000382:microbiology / Q000473:pathology; D009474:Neurons / Q000382:microbiology* / Q000473:pathology / Q000502:physiology; D014407:Tumor Cells, Cultured; D014779:Virus Replication