Central nervous system receptor binding profiles of some 2-amino-4-phenyl quinolines: a novel class of alpha 2-adrenoceptor selective ligands.
The 2-amino-4-phenyl quinoline moiety is a structural motif common to a number of central nervous system active agents. Extensive radio-ligand receptor binding profiles for several derivatives of this common structural feature have been determined. A high base level of central nervous system receptor affinity was observed with a distinct preference for the alpha-, and in particular the alpha 2-, adrenoceptors.
Nicholls
I A
IA
Department of Pharmaceutical Chemistry, Victorian College of Pharmacy, Parkville, Australia.
Morrison
S F
SF
Brinkworth
R I
RI
Alewood
P F
PF
Andrews
P R
PR
D000818:Animals; D002417:Cattle; D002490:Central Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D011804:Quinolines / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D013329:Structure-Activity Relationship
D011804:Quinolines; D018341:Receptors, Adrenergic, alpha-2