Familial transitional cell carcinoma and the Lynch syndrome II.
A family is presented in which 4 male siblings developed transitional cell carcinoma (TCC). Four upper tract tumours occurred in 3 and in the fourth the tumour was intravesical. Two of these patients also had colorectal adenocarcinoma. There were 2 other relatives in the pedigree with large bowel cancer. It is suggested that this is an example of Lynch Syndrome II, a hereditary non-polyposis colorectal cancer with extracolonic cancer sites. The implications regarding the screening, surveillance and detection of possible carrier status in healthy relatives is discussed.
Greenland
J E
JE
Department of Urology, Queen Elizabeth Hospital, Birmingham.
Weston
P M
PM
Wallace
D M
DM
D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000209:etiology / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D014571:Urologic Neoplasms / Q000209:etiology / Q000235:genetics*