Stimulation of rat spleen cells by staphylococcal enterotoxins.
There is much interest in staphylococcal enterotoxins as T cell mitogens in humans, mice and rabbits. Rat spleen cells were shown to proliferate in response to staphylococcal enterotoxins A and B and toxic shock syndrome toxin-1 at concentrations (5 to 500 ng ml-1) which also stimulate mouse spleen cells. The proliferative response to all these enterotoxins was inhibited by cyclosporin A, indicating the response to be predominantly that of T cells. These results indicate that the rat provides another convenient model for the analysis of T cell responses to enterotoxins.
Holbrook
M R
MR
Department of Microbiology, Queen's Medical Centre, Nottingham, UK.
Young
K E
KE
Gibbon
L G
LG
Webster
C A
CA
Tranter
H S
HS
Arbuthnott
J P
JP
Todd
I
I
D000818:Animals; D001427:Bacterial Toxins; D002478:Cells, Cultured; D004768:Enterotoxins / Q000276:immunology*; D008213:Lymphocyte Activation; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; C026066:enterotoxin A, Staphylococcal; C031818:enterotoxin B, staphylococcal