title: Acute lymphoblastic leukaemia incidence in the UK by immunophenotype.
abstract: The incidence of acute lymphoblastic leukaemia (ALL) is described for both children and adults for the three major immunophenotypes: null, CD10-positive (CD+) which includes both common and pre-B types, and T-cell (including pre-T variants). The data are derived from a population-based specialist registry of leukaemias and lymphomas covering approximately one-half of England and Wales. Null ALL predominates in those under 1 year old and CD10+ ALL in the 1-7 year olds. There is a male excess at all ages for T-cell disease, which is particularly prominent in adolescents and young adults. The effect of socioeconomic levels is seen most clearly for CD10+ ALL in the childhood peak, where B-cell precursor disease occurs more frequently in areas of higher socioeconomic status.
authors.affiliation: Information and Statistics Division, Scottish Common Services Agency, Edinburgh, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: McKinney
authors.forename: F E
authors.initials: FE
authors.lastname: Alexander
authors.forename: R A
authors.initials: RA
authors.lastname: Cartwright
authors.forename: C S
authors.initials: CS
authors.lastname: Scott
authors.forename: A
authors.initials: A
authors.lastname: Staines
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification* / Q000453:epidemiology* / Q000276:immunology; D012959:Socioeconomic Factors; D006113:United Kingdom