Transgenic mice expressing C-reactive protein are susceptible to infection with Plasmodium yoelii sporozoites.
Human and rat C-reactive proteins, major acute-phase reactants, bind to sporozoites and inhibit their in vitro development in hepatocytes (A. Nussler, S. Pied, M. Pontet, F. Miltgen, L. Renia, M. Gentilini, and D. Mazier, Exp. Parasitol. 72:1-7, 1991, and S. Pied, A. Nussler, M. Pontet, F. Miltgen, H. Matile, P.-H. Lambert, and D. Mazier, Infect. Immun. 57:278-282, 1989). We show here that rabbit C-reactive protein has identical properties. Nevertheless, infection by Plasmodium yoelii sporozoites was not prevented in transgenic mice engineered to express rabbit C-reactive protein following induction of gluconeogenesis.
Rénia
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Michael Heidelberger Division of Immunology, Department of Pathology, New York University School of Medicine, New York 10016-6402.
Xia
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Samols
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Nussenzweig
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D000818:Animals; D002097:C-Reactive Protein / Q000096:biosynthesis / Q000276:immunology*; D004198:Disease Susceptibility; D066298:In Vitro Techniques; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology* / Q000378:metabolism; D010962:Plasmodium berghei / Q000276:immunology; D010967:Plasmodium yoelii / Q000276:immunology*; D013171:Spores, Bacterial
D002097:C-Reactive Protein