title: Prednisolone, cytosine arabinoside, lomustine (CCNU), etoposide and thioguanine (PACET) combination chemotherapy for relapsed or refractory non-Hodgkin lymphoma.
abstract: 27 patients with relapsed/refractory non-Hodgkin lymphoma (NHL) received combination chemotherapy with prednisolone, cytosine arabinoside, lomustine (CCNU), etoposide and thioguanine (PACET). 25 patients are evaluable for response. 7 (26%) obtained a complete response and one (4%) a partial response. The median survival for the entire group was 6 months. 2 patients are currently alive without disease, 1 of whom has received further therapy. The regimen was intensely myelosuppressive, but was well tolerated. The complete response rate and median survival figures are comparable to previous studies of salvage therapy confirming the poor prognosis for relapsed NHL and emphasising the need for prospective randomised studies.
authors.affiliation: CRC Wessex Medical Oncology Unit, University of Southampton, Southampton General Hospital, U.K.
authors.forename: J W
authors.initials: JW
authors.lastname: Sweetenham
authors.forename: J J
authors.initials: JJ
authors.lastname: McKendrick
authors.forename: G M
authors.initials: GM
authors.lastname: Mead
authors.forename: J M
authors.initials: JM
authors.lastname: Whitehouse
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D011239:Prednisolone / Q000008:administration & dosage; D011379:Prognosis; D011446:Prospective Studies; D013866:Thioguanine / Q000008:administration & dosage
chemical_list: D003561:Cytarabine; D005047:Etoposide; D008130:Lomustine; D011239:Prednisolone; D013866:Thioguanine