A comparison of pefloxacin/metronidazole and doxycycline/metronidazole in the treatment of laparoscopically confirmed acute pelvic inflammatory disease.
A double-blind, randomised study was conducted to compare the efficacy and safety of a combination of pefloxacin and metronidazole versus doxycycline and metronidazole in patients with pelvic inflammatory disease (PID). The clinical diagnosis had to be confirmed by laparoscopy before patients were included. Of the 74 patients who fulfilled the clinical criteria for PID, laparoscopy confirmed the diagnosis in only 40 patients (54%). The microorganism most frequently found as causative pathogen was Chlamydia trachomatis. Both treatment groups showed a good response to the study-medication. At discharge 9 patients in the pefloxacin group (45%) were cured and 10 patients (50%) had improved. In the doxycycline group 7 patients (35%) were cured and 10 patients (50%) had improved. Obviously pefloxacin/metronidazole and doxycycline/metronidazole are equally effective in the treatment of PID.
Witte
E H
EH
Department of Gynecology and Reproduction, Leiden University Medical Center, The Netherlands.
Peters
A A
AA
Smit
I B
IB
van der Linden
M C
MC
Mouton
R P
RP
van der Meer
J W
JW
van Erp
E J
EJ
D000208:Acute Disease; D002692:Chlamydia trachomatis; D004311:Double-Blind Method; D004318:Doxycycline / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008795:Metronidazole / Q000008:administration & dosage*; D015366:Pefloxacin / Q000008:administration & dosage*; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
D008795:Metronidazole; D015366:Pefloxacin; D004318:Doxycycline