title: Anterior pituitary function after adrenalectomy in patients with Cushing's syndrome.
abstract: We assessed anterior pituitary function in five patients with Cushing's syndrome before and after the removal of cortisol-secreting adrenal adenomas. Before surgery, all patients lacked response of growth hormone to hypoglycaemia, four had low responses of thyrotrophin to thyrotrophin releasing hormone, three had hypogonadism and two had low prolactin reserve. After successful removal of the adrenal adenoma, all patients developed postoperative hypoadrenocorticism and recovered all impaired anterior pituitary hormones within a period of 3 months. Our results point to a direct inhibiting action of glucocorticoids at the pituitary level as the explanation for the impaired anterior pituitary function. Moreover, direct gonadal suppression by glucocorticoids may be an additional mechanism of hypogonadism in some patients.
authors.affiliation: Service of Clinical Endocrinology, Clinica Puerta de Hierro, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Marazuela
authors.forename: C
authors.initials: C
authors.lastname: Cuerda
authors.forename: T
authors.initials: T
authors.lastname: Lucas
authors.forename: A
authors.initials: A
authors.lastname: Vicente
authors.forename: C
authors.initials: C
authors.lastname: Blanco
authors.forename: J
authors.initials: J
authors.lastname: Estrada
mesh_terms: D000315:Adrenalectomy; D000328:Adult; D003480:Cushing Syndrome / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D011184:Postoperative Period; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone