title: Splenectomy in idiopathic thrombocytopenic purpura: its correlation with the sequestration of autologous indium-111-labeled platelets.
abstract: We present a retrospective analysis of 111In-platelet sequestration studies in 111 patients with the clinical diagnosis of idiopathic thrombocytopenic purpura (ITP). Fifty-one of these patients underwent splenectomy, independent of the results of the 111In-platelet studies to determine if these isotopic results could accurately predict a beneficial response to splenectomy. Between January 1984 and June 1990, 111 patients who presented with ITP were subjected to a study of autologous 111In-labeled platelets through autotransfusion. The platelet sequestration site was splenic (81%), mixed (12%), or hepatic (7%). Fifty-one patients with persistent drug-resistant thrombocytopenia underwent splenectomy regardless of the isotopic results: 33 patients beyond 6 mo after diagnosis and 18 with high hemorrhagic risks before this delay. The follow-up median duration was 2.9 yr. Thirty-three of the 38 patients with splenic sequestration showed a normalized platelet count, as opposed to 2 of the 13 with mixed or hepatic sequestration (p < 0.001). In addition, platelet survival extended beyond 8 days in six patients, with no apparent sequestration site. The platelet isotopic study performed with this technique appears to be indicated in ITP: it guides clinicians in their decision to perform splenectomy and relates to a more central mechanism certain thrombocytopenias that are inappropriately categorized as ITP.
authors.affiliation: Department of Hematology, Hopital Pontchaillou, Rennes, France.
authors.forename: T
authors.initials: T
authors.lastname: Lamy
authors.forename: A
authors.initials: A
authors.lastname: Moisan
authors.forename: C
authors.initials: C
authors.lastname: Dauriac
authors.forename: C
authors.initials: C
authors.lastname: Ghandour
authors.forename: P
authors.initials: P
authors.lastname: Morice
authors.forename: P Y
authors.initials: PY
authors.lastname: Le Prise
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000000981:diagnostic imaging* / Q000601:surgery*; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013154:Spleen / Q000000981:diagnostic imaging; D013156:Splenectomy
chemical_list: D007205:Indium Radioisotopes