Akinetic-rigid syndrome in a 13-year-old girl with HIV-related progressive multifocal leukoencephalopathy.
A 13-year-old HIV-infected girl presented with a rapidly progressive akinetic-rigid syndrome. Cranial magnetic resonance imaging revealed bilateral centrum semiovale lesions extending into the basal ganglia. Detailed histopathological study of a biopsy specimen from the involved regions resulted in a diagnosis of progressive multifocal leukoencephalopathy (PML). This case illustrates that an akinetic-rigid syndrome may be a rare presentation of PML. HIV-related PML may have unusual radiological features. Brain biopsy may be necessary to confirm PML in cases associated with atypical clinical and radiological presentations.
Singer
C
C
Department of Neurology, University of Miami School of Medicine, Florida.
Berger
J R
JR
Bowen
B C
BC
Bruce
J H
JH
Weiner
W J
WJ
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology; D000293:Adolescent; D001706:Biopsy; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009069:Movement Disorders / Q000175:diagnosis* / Q000473:pathology; D009127:Muscle Rigidity / Q000175:diagnosis* / Q000473:pathology; D009186:Myelin Sheath / Q000473:pathology; D009460:Neurologic Examination