Effect of recombinant IL-3 on lymphocyte populations in irradiated mice.
Administration of murine recombinant interleukin 3 (IL-3) to sublethally irradiated mice induced in the thymus recovery of the cell count and mitotic responsiveness to Con A, as well as a decrease in CD4-CD8- cells concomitant with an increase in single positive cells. Also in the spleen, the cell count and mitotic responsiveness to Con A and lipopolysaccharide (LPS) were recovered by IL-3 treatment. These findings show that IL-3 induces differentiation and growth of thymocytes and recovery of T and B cell functions in sublethally irradiated mice.
Doria
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Division of Molecular Biology, Biophysics and Bioelectronics, ENEA C.R.E. Casaccia, Rome, Italy.
Leter
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Mancini
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Frasca
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D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D007377:Interleukin-3 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011994:Recombinant Proteins / Q000494:pharmacology; D014916:Whole-Body Irradiation
D007377:Interleukin-3; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D003208:Concanavalin A