[Effect of calcium antagonists on the hemodynamic and pancreatic secretory parameters in diabetes mellitus].
Data are presented concerning the basal levels of parathormone and calcitonin and the effect of dihydropyridine derivatives on the characteristics of haemodynamics as well as pancreatic secretory activity in patients with diabetes mellitus. It is shown that in diabetic patients with hypertension a single administration of the drugs induces vasodilatation which causes lowering of systolic and diastolic blood pressure. In patients with diabetes mellitus in combination with hypertension, heart coronary disease and obvious peripheral angiopathy (similar procedure) no peripheral vasodilatation was observed. No negative effects were observed on the compensatory processes (and obviously on pancreatic secretory activity in patients with both insulin-dependent and insulin-independent diabetes mellitus even during long-lasting administration of drugs. A conclusion is made that calcium channel antagonists should be recommended to patients with diabetes mellitus taking into account the state of their peripheral vessels.
Zubkova
S T
ST
Kostiuk
E P
EP
Bulat
O V
OV
D000293:Adolescent; D000328:Adult; D002116:Calcitonin / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use*; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism
D010281:Parathyroid Hormone; D002116:Calcitonin; D009543:Nifedipine