title: Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults.
abstract: Based on previous cross-sectional findings, we hypothesized that weight loss could improve several hemostatic factors associated with cardiovascular disease. In a randomized controlled trial, moderately overweight men and women were assigned to one of four weight loss treatment groups or to a control group. Measurements of plasminogen activator inhibitor-1 (PAI-1) antigen, tissue-type plasminogen activator (t-PA) antigen, D-dimer antigen, factor VII activity, fibrinogen, and protein C antigens were made at baseline and after 6 months in 90 men and 88 women. Net treatment weight loss was 9.4 kg in men and 7.4 kg in women. There was no net change (p > 0.05) in D-dimer, fibrinogen, or protein C with weight loss. Significant (p < 0.05) decreases were observed in the combined treatment groups compared with the control group for mean PAI-1 (31% decline), t-PA antigen (24% decline), and factor VII (11% decline). Decreases in these hemostatic variables were correlated with the amount of weight lost and the degree that plasma triglycerides declined; these correlations were stronger in men than women. These findings suggest that weight loss can improve abnormalities in hemostatic factors associated with obesity.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015.
authors.forename: A R
authors.initials: AR
authors.lastname: Folsom
authors.forename: H T
authors.initials: HT
authors.lastname: Qamhieh
authors.forename: R R
authors.initials: RR
authors.lastname: Wing
authors.forename: R W
authors.initials: RW
authors.lastname: Jeffery
authors.forename: V L
authors.initials: VL
authors.lastname: Stinson
authors.forename: L H
authors.initials: LH
authors.lastname: Kuller
authors.forename: K K
authors.initials: KK
authors.lastname: Wu
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005167:Factor VII / Q000032:analysis*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D005167:Factor VII; D002784:Cholesterol; D010959:Tissue Plasminogen Activator