Re-localization of Actsk-1 to mouse chromosome 8, a new region of homology with human chromosome 1.
We present here the genetic mapping of the alpha-skeletal actin locus (Actsk-1) on mouse Chromosome (Chr) 8, on the basis of the PCR analysis of a microsatellite in an interspecific backcross. Linkage and genetic distances were established for four loci by analysis of 192 (or 222) meiotic events and indicated the following gene order: (centromere)-Es-1-11.7 cM-Tat-8.3 cM-Actsk-1-0.5 cM-Aprt. Mapping of ACTSK to human Chr 1 and of TAT and APRT to human Chr 16 demonstrates the existence of a new short region of homology between mouse Chr 8 and human Chr 1. Intermingling on this scale between human and mouse chromosomal homologies that occurred during evolution creates disorders in comparative linkage studies.
Alonso
S
S
Unité de Génétique Moléculaire du Développement, URA 1148, Institut Pasteur, Paris, France.
Montagutelli
X
X
Simon-Chazottes
D
D
Guénet
J L
JL
Buckingham
M
M
D000199:Actins / Q000235:genetics*; D000228:Adenine Phosphoribosyltransferase / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D004276:DNA, Satellite / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D000199:Actins; D004276:DNA, Satellite; D000228:Adenine Phosphoribosyltransferase