Cytoplasmic GpIIb-IIIa and cytokine secretion by blasts in a case of megakaryoblastic transformation of essential thrombocythemia.
A 49-year-old woman with a four year history of therapy resistant essential thrombocythemia, progressed to acute leukemia that also proved refractory to chemotherapy. Blast cell features including immunophenotype, cytogenetics and in vitro cell cultures, suggested megakaryoblastic leukemia. In serum-free culture, blasts released GM-CSF and IL-6 which sustained autocrine growth and promoted normal myeloid and megakaryocytic colony formation.
Selleri
C
C
Division of Hematology, 2nd Medical School, University of Naples, Italy.
Alfinito
F
F
Del Vecchio
L
L
Luciano
L
L
De Renzo
A
A
Rotoli
B
B
D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation / Q000276:immunology* / Q000502:physiology; D008875:Middle Aged; D010980:Platelet Membrane Glycoproteins / Q000276:immunology; D013920:Thrombocythemia, Essential / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D016207:Cytokines; D010980:Platelet Membrane Glycoproteins