title: Erythromycin accelerates gastric emptying of indigestible solids and transpyloric migration of the tip of an enteral feeding tube in fasting and fed states.
abstract: Erythromycin has been shown to initiate gastric interdigestive migrating motor complexes, which are the motor events responsible for gastric emptying of indigestible solids. Hence, erythromycin should also accelerate gastric emptying of indigestible particles and facilitate transpyloric migration of the tip of an enteral feeding tube. Accordingly, we assessed the effect of erythromycin on these events, using a single-blind crossover study. Healthy subjects were nasally intubated with an enteral feeding tube. For fasting studies, the subjects remained fasted; in the fed studies, the subjects were fed a cheeseburger and fries after placement of the feeding tube. Then, ten 1-cm radiopaque plastic segments were swallowed by each subject, followed by an iv infusion of either erythromycin (200 mg over 20 min) or saline. Abdominal x-rays were then taken at regular intervals to document the location of the tube tip and the plastic segments. Erythromycin significantly shortened gastric emptying time of the indigestible particles during both fasting and fed states. Erythromycin also accelerated transpyloric migration of the tip of the feeding tube in both fasting and fed states. Hence, erythromycin can be beneficial when placement of a feeding tube in the small intestine is clinically desired.
authors.affiliation: Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
authors.forename: A
authors.initials: A
authors.lastname: Keshavarzian
authors.forename: R M
authors.initials: RM
authors.lastname: Isaac
mesh_terms: D000328:Adult; D004435:Eating / Q000502:physiology; D004750:Enteral Nutrition / Q000295:instrumentation*; D004917:Erythromycin / Q000494:pharmacology*; D005215:Fasting / Q000502:physiology; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007441:Intubation, Gastrointestinal; D008297:Male; D016037:Single-Blind Method
chemical_list: D004917:Erythromycin