title: Effects of systemic and topical nicotine on pulpal blood flow in dogs.
abstract: It has been suggested that nicotine exerts cardiovascular effects which are similar to stimulation of the sympathoadrenal system. If this observation is true, nicotine administration would decrease pulpal blood flow and possible alter the pulpal response to injury. The purpose of this study was to measure pulpal blood flow in dogs using the radiolabelled microsphere method following topical or systemic administration of nicotine for 28 days. Thirteen dogs were divided into three groups. Group one received topical nicotine (8 mg nicotine/kg/day) combined with orabase which was applied in two equal doses to the mandibular anterior gingiva. Group two received systemic nicotine (2.5 mg/kg/day) delivered by osmotic pumps implanted subcutaneously in the back of each animals' neck. Group three were controls, and these animals received either topical orabase twice daily applied to the mandibular anterior gingiva or saline via osmotic pumps. Results indicated pulpal blood flow increased from Day 0 to Day 28 in both nicotine treated groups. Group one (topical nicotine) exhibited a mean increase in blood flow of 21.8 ml/min/100 g, while group two exhibited a mean increase of 50.1 ml/min/100 g. Group three, the control animals, exhibited a mean decrease in pulpal blood flow of 22.1 ml/min/100 g over the 28-day interval. These changes were not statistically significant (p > 0.05).
authors.affiliation: Department of Endodontics, University of Nebraska Medical Center, College of Dentistry, Lincoln.
authors.forename: W T
authors.initials: WT
authors.lastname: Johnson
authors.forename: G K
authors.initials: GK
authors.lastname: Johnson
authors.forename: G L
authors.initials: GL
authors.lastname: Todd
authors.forename: Y K
authors.initials: YK
authors.lastname: Fung
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003367:Cotinine / Q000097:blood / Q000494:pharmacology; D003782:Dental Pulp / Q000098:blood supply*; D004285:Dogs; D008833:Microcirculation / Q000187:drug effects*; D009538:Nicotine / Q000097:blood / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D009538:Nicotine; D003367:Cotinine