Angiosarcoma of the uterus following radiotherapy for squamous cell carcinoma of the cervix.
A case report of a 61-year-old woman who developed a uterine angiosarcoma 6.5 years after primary radiotherapy for a moderately well differentiated squamous cell carcinoma of the uterine cervix stage IB is presented. The diagnosis was confirmed by immunohistochemical studies showing positive staining for Ulex europaeus agglutinin 1 and supported by ultrastructural studies. Though various post-irradiation angiosarcomas are reported in the literature, this is, to our knowledge, the first report of an angiosarcoma of the uterus after radiotherapy.
Morrel
B
B
Department of Gynaecology and Obstetrics, Ikazia Hospital, Montessoriweg, Rotterdam, The Netherlands.
Mulder
A F
AF
Chadha
S
S
Tjokrowardojo
A J
AJ
Wijnen
J A
JA
D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D009367:Neoplasm Staging; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D014594:Uterine Neoplasms / Q000209:etiology*