title: Regional cerebral blood flow in chronic stroke patients.
abstract: OBJECTIVE
  The aim of this study was to investigate regional cerebral blood flow parameters during the postacute phase of unilateral ischemic stroke and to correlate them with clinical data.
  
  
  METHODS
  Regional cerebral blood flow was measured in 187 patients in the stabilized phase of stroke by the xenon-133 inhalation method with 32 extracranial detectors. Thirty-eight patients were reexamined after a mean +/- SD time of 32 +/- 21.4 months.
  
  
  RESULTS
  The overall detection of hypoperfusion was 92.0%, with asymmetries as the most sensitive index, especially for patients with a lesser degree of neurological disability. Neurological disability score was strongly associated with regional cerebral blood flow in the affected hemisphere (p < 0.0001) and with asymmetries (p < 0.0001). The presence of carotid obstruction further decreased the regional cerebral blood flow in the affected hemisphere and significantly increased asymmetry (p < 0.0001). Subjects who had no hypoperfusion at absolute values analysis were more frequently free of carotid disease and had less severe disability than those who had bilateral or unilateral regional absolute cerebral blood flow reduction. In 38 patients without new cerebrovascular events, a significant (p = 0.005) reduction of hemispheric regional cerebral blood flow asymmetries was found on a follow-up examination.
  
  
  CONCLUSIONS
  These data confirm the value of regional cerebral blood flow asymmetries in stroke detection and point out that important clinical information is also contained in absolute values analysis.
authors.affiliation: Department of Motor Science-Neurophysiopathology, University of Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez
authors.forename: F
authors.initials: F
authors.lastname: Nobili
authors.forename: F
authors.initials: F
authors.lastname: De Carli
authors.forename: S
authors.initials: S
authors.lastname: Francione
authors.forename: S
authors.initials: S
authors.lastname: Marenco
authors.forename: M A
authors.initials: MA
authors.lastname: Celestino
authors.forename: K
authors.initials: K
authors.lastname: Hassan
authors.forename: G
authors.initials: G
authors.lastname: Rosadini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D004453:Echoencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed