title: Traumatic brain tissue acidosis: experimental and clinical studies.
abstract: We have been focusing on potential metabolic derangement associated with severe head injury and a clinical trail directed toward treating brain tissue acidosis is currently underway. More specifically, we based this study on the hypothesis that following brain trauma brain tissue acidosis develops which may contribute to the prolongation of coma and neurologic deficit. Tromethamine (THAM), a safe and low toxicity agent which buffers in major part by causing a hypocapnic alkalosis, was selected for trial. Patients admitted with GCS < 8 were randomized into one of three arms: control: THAM plus hyperventilation; hyperventilation alone. Each regimen was maintained for 5 days post injury. Our analysis of 3 and 6 months Glasgow outcome score showed that prophylactic hyperventilation retards recovery, and the use of THAM overcomes the apparent deleterious effects of hyperventilation. One explanation is that the reduced ICP instability observed in THAM treated patients may account for this improvement. Is THAM effective in buffering traumatized brain tissue? What factors account for improvement in ICP stability? We addressed these questions in experimental studies utilizing MR spectroscopy to measure brain lactate production and tissue pH in fluid percussed anaesthetized cats. The protocol was designed to match our clinical trial, and brain injured animals were randomized into control, THAM, and hyperventilated groups. We observed that brain lactate production increased with trauma and remained above control at 8 hrs post injury. Lactate production in THAM treated animals was not elevated. Highest lactate production was associated with injured animals treated with sustained hyperventilation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Neurosurgery, Medical College of Virginia, Richmond.
authors.forename: A
authors.initials: A
authors.lastname: Marmarou
authors.forename: R
authors.initials: R
authors.lastname: Holdaway
authors.forename: J D
authors.initials: JD
authors.lastname: Ward
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: S C
authors.initials: SC
authors.lastname: Choi
authors.forename: J P
authors.initials: JP
authors.lastname: Muizelaar
authors.forename: H F
authors.initials: HF
authors.lastname: Young
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000502:physiology; D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D016489:Head Injuries, Closed / Q000503:physiopathology*; D006801:Humans; D007773:Lactates / Q000134:cerebrospinal fluid; D019344:Lactic Acid; D014325:Tromethamine / Q000494:pharmacology
chemical_list: D007773:Lactates; D014325:Tromethamine; D019344:Lactic Acid