[Bioassay of Lyso-PAF platelet activating factor and it's role in bronchial asthma].
Plasma and lung homogenate lyso-PAF were measured by using the method of bioassay in guinea pigs with allergic asthma and asthmatic patients. The results showed that Lyso-PAF levels were increased significantly in asthmatics, and it was positively correlated with TXB2 levels. It is suggested that PAF plays an important role in bronchial asthma, which may be correlated with TXA2. The method of bioassay of Lyso-PAF is stable, reliable and special instruments are not needed.
Fu
J
J
81st Hospital of PLA, Nanjing.
Yu
H P
HP
Li
P S
PS
D000293:Adolescent; D000328:Adult; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000378:metabolism*; D001681:Biological Assay; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010047:Ovalbumin; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000378:metabolism; D013929:Thromboxane B2 / Q000097:blood
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D013929:Thromboxane B2; D010047:Ovalbumin