[Effect of paracetamol on the acid hemolysis of erythrocytes, with special reference to the intracellular glutathione level].
The authors give account of their study concerning the effect of paracetamol on the acid haemolysis, and glutathione content of human erythrocytes. In vitro, paracetamol decreased intracellular glutathione content in a dose dependent manner. This may lead to an increased sensitivity of erythrocytes to the haemolytic effect of hydrochloric acid, what may explain the dose dependent decrease of time of haemolysis, presented in form of dynamic haemolysis curve. In vivo four hours following the oral intake of 500 mg paracetamol, although the intracellular glutathione content did not decrease significantly, shortening of the time of acid haemolysis could be demonstrated in more than half of the persons studied. No haemolysis was caused by the given dose of the drug.
Altorjay
I
I
Debreceni Orvostudományi Egyetem II. Belklinika, Debrecen.
Sári
B
B
Imre
S
S
Balla
G
G
Dalmi
L
L
D000082:Acetaminophen / Q000494:pharmacology*; D000143:Acids / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects*; D005978:Glutathione / Q000097:blood*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans
D000143:Acids; D000082:Acetaminophen; D005978:Glutathione