Potential antitumor agents. XX (1). 6-Anilinoimidazo[2,1-b]thiazoles.
The synthesis of 6-anilinoimidazo[2,1-b]thiazoles, related to the well-known antitumor agent amsacrine, is reported. The cytotoxic activity of the new compounds was evaluated on HeLa cells. Compound 3a, the most closely related to amsacrine, was significantly active.
Andreani
A
A
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
Rambaldi
M
M
Locatelli
A
A
Bossa
R
R
Fraccari
A
A
Galatulas
I
I
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D007093:Imidazoles; D013844:Thiazoles