Prolactin response to dl-fenfluramine in panic disorder.
The objective of this study was to test the hypothesis that serotonin receptors are hypersensitive in patients with panic disorder. Eleven patients and 12 controls received a single PO dose of 60 mg of dl-fenfluramine at 0900h on a single occasion. Blood samples were collected with an indwelling intravenous catheter at 30-min intervals from 0930h to 1530h and prolactin determined by radioimmunoassay. In both groups, fenfluramine induced a rise in the plasma prolactin concentration from baseline. The patients showed a greater increase in prolactin response than the normal controls. This result is consistent with the hypothesis of increased serotonin receptor function in patients with panic disorder.
Apostolopoulos
M
M
University of Melbourne, Department of Psychiatry, Austin Hospital, Heidelberg, Victoria, Australia.
Judd
F K
FK
Burrows
G D
GD
Norman
T R
TR
D000284:Administration, Oral; D000328:Adult; D005260:Female; D005277:Fenfluramine; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D011388:Prolactin / Q000097:blood*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
D011985:Receptors, Serotonin; D005277:Fenfluramine; D011388:Prolactin