Differential processing of provasotocin: relative increase of hydrin 2 (vasotocinyl-Gly) in amphibians able to adapt to an arid environment.
Hydrin 2 (vasotocinyl-Gly) is an intermediate in pro-vasotocin processing found, along with vasotocin, only in the neurohypophysis of anuran amphibians. It increases cutaneous water permeability in the frog and is likely involved in neuroendocrine control of osmoregulation. The relative amounts of vasotocin and hydrin 2 stored in neurohypophysis have been measured on the one hand in amphibian species known not to adapt in dry areas, on the other hand in two species, Bufo regularis (Africa) and Bufo viridis (Near-East) able to survive in an arid environment. In the first group, the proportions of the two peptides are approximately equal whereas in the two toads the molar ratio hydrin 2 to vasotocin reaches 2. The ratio does not appear to vary significantly when these toads are either submitted to dehydration or placed in saline solutions. Predominance of hydrin 2 suggests an adaptive decrease of the activity of the alpha-amidating enzymatic system involved in the conversion of vasotocinyl-Gly into mature amidated vasotocin.
Michel
G
G
Laboratory of Biological Chemistry, University of Paris VI 96, France.
Ouedraogo
Y
Y
Chauvet
J
J
Katz
U
U
Acher
R
R
D000064:Acclimatization; D000818:Animals; D002023:Bufo bufo / Q000502:physiology; D002025:Bufonidae / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid; D003889:Desert Climate; D004792:Enzyme Precursors / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000737:chemistry / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000737:chemistry / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011892:Rana catesbeiana / Q000502:physiology; D011893:Rana esculenta / Q000502:physiology; D011894:Rana pipiens / Q000502:physiology; D011898:Ranidae / Q000502:physiology*; D012462:Saline Solution, Hypertonic; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000032:analysis / Q000096:biosynthesis* / Q000378:metabolism*
D004792:Enzyme Precursors; D012462:Saline Solution, Hypertonic; C060258:hydrin 2; D014668:Vasotocin