title: Local skin-fold thickness as a clinical predictor of depot size during basal rate infusion of insulin.
abstract: OBJECTIVE
  To determine the influence of local adiposity on insulin depot size during CSII at basal rate.
  
  
  METHODS
  In 27 diabetic patients, a constant infusion of 125I-labeled Actrapid insulin was given, with U-40 insulin at a rate of 1.12 IU/h in 20 patients, and U-100 at a rate of 1 IU/h in 7 patients. After 16 h of infusion, the steady-state depot size was measured by external counting, and the local skin fold was measured with a Harpenden skin-fold caliper.
  
  
  RESULTS
  U-40 insulin infusion resulted in a steady-state depot size of 5.1 U (2.1-10.9 U), and a corresponding skin-fold thickness of 17.8 mm (5-34 mm). A positive correlation was found between depot size and skin-fold thickness. A similar correlation was observed with U-100 insulin.
  
  
  CONCLUSIONS
  During basal rate CSII, large variations in local skin-fold thickness create large variations in the steady-state depot size, which is partly predictable just by lifting the skin fold.
authors.affiliation: Hvidøre Hospital, Klampenborg, Denmark.
authors.forename: P R
authors.initials: PR
authors.lastname: Hildebrandt
authors.forename: A A
authors.initials: AA
authors.lastname: Vaag
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology / Q000503:physiopathology; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics*; D007332:Insulin Infusion Systems; D061389:Insulin, Regular, Pork; D007457:Iodine Radioisotopes; D008297:Male; D012885:Skinfold Thickness
chemical_list: D007328:Insulin; D061389:Insulin, Regular, Pork; D007457:Iodine Radioisotopes; C000006:insulin, neutral