[Specific inhibitors of plasminogen activators].
The article contains a survey of the recent papers on the fibrinolytic inhibitors which regulate the process of plasminogen activation--PAI-1 and PAI-2. Both of them belong to serine protease inhibitors family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1:1 with them. PAI-1, secreted mainly by endothelial cells and platelets, is the main plasmic inhibitor of plasminogen activation. PAI-2, originated essentially from placenta, appears in blood during pregnancy.
Mirowski
M
M
Zakład Biochemii Instytutu Badania Srodowiska i Bioanalizy Akademii Medycznej, Lodzi.
Wierzbicki
R
R
D000818:Animals; D006801:Humans; D010920:Placenta / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*; D017396:Plasminogen Activator Inhibitor 2 / Q000502:physiology*; D012016:Reference Values; D014652:Vascular Diseases / Q000378:metabolism
D017395:Plasminogen Activator Inhibitor 1; D017396:Plasminogen Activator Inhibitor 2