[Proteoglycans (their structure, function and role in liver diseases)].
Proteoglycans are macromolecules containing a core protein to which glycosaminoglycan chains are covalently attached. The family contains several members with different structures and various functions. Some of them are elements of the extracellular matrix, while others are located to the cell surface playing important role in cell-cell and cell-extracellular matrix interactions. Present paper discusses the possible consequences of the alterations of proteoglycans observed in liver cirrhosis and liver tumors. It has to be emphasized however, that they are also involved in the pathomechanism of arteriosclerosis, Alzheimer-disease, immune diseases, arthritis, tumor progression and metastasis formation.
Kovalszky
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I
Semmelweis Orvostudományi Egyetem, Budapest, I. sz. Pathologiai és Kísérleti Rákkutató Intézet.
Jeney
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A
Lapis
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K
D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000145:classification; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000378:metabolism* / Q000473:pathology; D008113:Liver Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D011509:Proteoglycans / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
D016326:Extracellular Matrix Proteins; D006025:Glycosaminoglycans; D011509:Proteoglycans