Promoter resurrection by activators--a minireview.
Frequently, in nature, defective promoters can be resurrected by activator proteins in response to cellular demands. The activators bind to nearby DNA sites for action. Various protein-protein and DNA-protein contacts involving activators, RNA polymerase, and different segments of DNA in and around a defective promoter form a DNA-multiprotein complex (cage) which enhances transcription.
Adhya
S
S
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Gottesman
M
M
Garges
S
S
Oppenheim
A
A
D004247:DNA / Q000737:chemistry; D009690:Nucleic Acid Conformation; D011401:Promoter Regions, Genetic; D012808:Sigma Factor / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*
D012808:Sigma Factor; D015534:Trans-Activators; D004247:DNA