[Protective effect of propentophylline (HWA 285) in ischemic spinal cord injury].
The effect of propentophylline (HWA 285) on the course of the functional regeneration of the hind extremities and on the regeneration of the energetic metabolism in the spinal cord after ischaemia produced by ligating the abdominal aorta for 20 or 30 mins was investigated. Administration of 20 mg/kg i.v. propentophylline after the induction of ischaemia produced marked regeneration of these parameters in comparison with ischaemia without administration of the drug in the course of four days. The protective effect of propentophylline administered prior to ischaemia was markedly weaker.
Chavko
M
M
Neurobiologický ústav SAV, Kosice.
Danielisová
V
V
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D011817:Rabbits; D013116:Spinal Cord / Q000098:blood supply*; D014970:Xanthines / Q000494:pharmacology*
D014970:Xanthines; C032114:propentofylline; D000255:Adenosine Triphosphate