title: Techniques for the measurement of the local myocardial extraction efficiency for inert diffusible contrast agents such as gadopentate dimeglumine.
abstract: We have previously shown that the concentration of Gd-DTPA as a function of time ([Gd-DTPA]t(t)) in the myocardium following an intravenous bolus injection of Gd-DTPA can be modeled using the Modified Kety Equation. Fitting this model to measurements of [Gd-DTPA]t(t) in a region of myocardium would allow the determination of myocardial distribution volume (lambda) and the product of flow (F) and extraction efficiency (E), i.e., FE. Thus, to measure F, E must be known. We describe here techniques developed to measure local values of E in normal and diseased myocardium. These techniques are valid for any inert diffusible MR contrast agent.
authors.affiliation: Department of Physics, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Canada.
authors.forename: C Y
authors.initials: CY
authors.lastname: Tong
authors.forename: F S
authors.initials: FS
authors.lastname: Prato
authors.forename: G
authors.initials: G
authors.lastname: Wisenberg
authors.forename: T Y
authors.initials: TY
authors.lastname: Lee
authors.forename: E
authors.initials: E
authors.lastname: Carroll
authors.forename: D
authors.initials: D
authors.lastname: Sandler
authors.forename: J
authors.initials: J
authors.lastname: Wills
mesh_terms: D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology; D004285:Dogs; D005682:Gadolinium; D019786:Gadolinium DTPA; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA