Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series.
Balasubramanian
N
N
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492.
St Laurent
D R
DR
Federici
M E
ME
Meanwell
N A
NA
Wright
J J
JJ
Schumacher
W A
WA
Seiler
S M
SM
D000447:Aldehydes / Q000138:chemical synthesis* / Q000494:pharmacology; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000991:Antithrombins / Q000138:chemical synthesis* / Q000494:pharmacology; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D008969:Molecular Sequence Data; D051381:Rats; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000447:Aldehydes; D000596:Amino Acids; D000991:Antithrombins; D004151:Dipeptides; C079295:BMY 44621; D013917:Thrombin