Histomorphological evaluation of wound healing of rabbit oviduct after microsurgical reanastomosis with the use of autologous fibrin adhesive, human fibrin adhesive or poly-glycolic acid suture.
The morphology of the healing process of microsurgical reanastomosis of the rabbit oviduct with the use of fibrin adhesive, autologous and heterologous, and conventional sutures is described. Both oviducts in 48 rabbits were cut and reanastomosis were performed. The rabbits were killed at different intervals after the operations, ranging from 2 h to 28 days, and the anastomoses were evaluated by histomorphological examination. The autologous fibrin adhesive was absorbed after a week and an uncomplicated healing was observed. Heterologous fibrin adhesive caused a granulomatous inflammation interpreted as an immune reaction of the host to the foreign protein, and conventional suturing resulted in severe tissue damage with an intensive inflammatory reaction.
Weis-Fogh
U S
US
Department of Experimental Research in Surgery, Panum Institute, University of Copenhagen, Denmark.
Pedersen
H
H
Schroeder
E
E
Sørensen
S S
SS
Olesen
H P
HP
D000818:Animals; D002196:Capillaries / Q000473:pathology; D005069:Evaluation Studies as Topic; D005187:Fallopian Tubes / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D005260:Female; D005337:Fibrin; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008866:Microsurgery; D011100:Polyglycolic Acid; D011817:Rabbits; D012038:Regeneration; D013243:Sterilization Reversal / Q000379:methods*; D013537:Sutures; D013997:Time Factors; D014014:Tissue Adhesives; D014945:Wound Healing
D014014:Tissue Adhesives; D011100:Polyglycolic Acid; D005337:Fibrin