title: Stimulatory effects on lactotrophs and crop-sac of interleukin-1 and interleukin-2 in pigeons (Columba livia).
abstract: The ultrastructural effects of human-recombinant interleukin-1 beta (IL-1 beta) and human-recombinant interleukin-2 (IL-2) on the crop-sac (the target organ for prolactin secretion in birds) and the anterior pituitary lactotrophs, were studied in pigeons (Columba livia). The intraventricular microinfusion of the two interleukins produced maximal crop-sac stimulation with milk-like secretion, as demonstrated by the observation of ultrastructural changes in the lactiferous areas through scanning and transmission electron microscopy of crop-sac mucosa. A marked activation of the anterior pituitary lactotrophs was also observed. Crop-sac and pituitary lactotrophs stimulatory effects were prevented by a previous intraventricular treatment with monoclonal antibodies for IL-1 beta and IL-2 receptors, but not by an intraperitoneal administration of naloxone. The present results show that interleukins possess in pigeons marked stimulatory effects on prolactin secretion and that these are mediated by specific receptors.
authors.affiliation: Faculty of Pharmacy, University of Reggio Calabria, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Rotiroti
authors.forename: E
authors.initials: E
authors.lastname: Ciriaco
authors.forename: G P
authors.initials: GP
authors.lastname: Germanà
authors.forename: F
authors.initials: F
authors.lastname: Naccari
authors.forename: S
authors.initials: S
authors.lastname: Gratteri
authors.forename: R
authors.initials: R
authors.lastname: Laurà
authors.forename: F
authors.initials: F
authors.lastname: Abbate
authors.forename: G
authors.initials: G
authors.lastname: Germanà
mesh_terms: D000818:Animals; D010856:Columbidae; D003426:Crop, Avian / Q000294:innervation*; D005260:Female; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D018123:Receptors, Interleukin / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D007375:Interleukin-1; D007376:Interleukin-2; D010908:Pituitary Hormones, Anterior; D018123:Receptors, Interleukin; D011994:Recombinant Proteins; D011388:Prolactin