Novel oxidative cleavage of C17-C20 bond in pregnane by a Pseudomonas sp.
Oxidative cleavage of the C17-C20 bond in progesterone by Pseudomonas sp. is reported. Transformation occurred under in vivo conditions. The bioconverted products were characterized as 1,4-androstadien-3,17-dione and 17 beta-hydroxy-1,4-androstadien-3-one. The steroid nucleus was not further degraded although the test organism had the capacity to induce dehydrogenation at C1 of this alpha, beta-conjugated steroid.
Dhar
A
A
Department of Microbiology, Bose Institute, Calcutta, India.
Samanta
T B
TB
D000730:Androstadienes / Q000378:metabolism; D002244:Carbon / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D011278:Pregnanes / Q000737:chemistry / Q000378:metabolism*; D011549:Pseudomonas / Q000378:metabolism*
D000730:Androstadienes; D011278:Pregnanes; C006573:1,4-androstadiene-3,17-dione; D002244:Carbon