title: [Oral ciprofloxacin therapy in juvenile patients with cystic fibrosis--results of a prospective pilot study].
abstract: Efficacy and safety of oral ciprofloxacin were studied in a prospective study at three cystic fibrosis centres, covering 24 in-patients suffering from cystic fibrosis and acute bronchopulmonary exacerbation. The patients were between 10 and 17 years of age. Pseudomonas infection was present in 75% of these patients. Despite frequent persistence of the pathogens, clinical improvement was noted in 75% of the treated children. A definite increase of the average MIC was not seen in 20 cases of persisting strains. No serious side effects occurred during the 14-day oral treatment course. Ciprofloxacin is a useful alternative to conventional parenteral treatment with antibiotics in patients suffering from cystic fibrosis and infections of the airways.
authors.affiliation: Klinik für Kinderheilkunde, Medizinischen Akademie Magdeburg.
authors.forename: V
authors.initials: V
authors.lastname: Sollich
authors.forename: E
authors.initials: E
authors.lastname: Klöditz
authors.forename: R
authors.initials: R
authors.lastname: Schuster
authors.forename: W
authors.initials: W
authors.lastname: Handrick
authors.forename: S
authors.initials: S
authors.lastname: Brömme
authors.forename: W
authors.initials: W
authors.lastname: Rumler
authors.forename: R
authors.initials: R
authors.lastname: Patsch
authors.forename: H
authors.initials: H
authors.lastname: Kharari
authors.forename: F B
authors.initials: FB
authors.lastname: Spencker
mesh_terms: D000293:Adolescent; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D002939:Ciprofloxacin