title: Developmental changes in the expression of HMG 2a protein.
abstract: The levels of HMG 2a chromosomal protein and its mRNA change during the post-hatched development of chicks were investigated. The contents of both HMG 2a and 2b proteins of liver, heart, brain, muscle and gizzard were abundant in the newly hatched chicks but their contents decreased significantly in those tissues of the 70-day-old chicks. The HMG 2a mRNA levels of liver, heart and brain in 70-day-old chick decreased to about 40% of those mRNA in the newly hatched chicks while the HMG 2a mRNA levels of muscle and gizzard in the 70-day-old chicks increased 5- and 3-fold, respectively. These results suggest that the decrease in the HMG 2a protein contents of the muscle and gizzard in the 70-day-old chicks may be largely due to the stimulation of HMG 2a protein degradation or the reduction of HMG 2a mRNA translation.
authors.affiliation: Department of Nutrition, School of Medicine, University of Tokushima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Sasakawa
authors.forename: N
authors.initials: N
authors.lastname: Komori
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
authors.forename: I
authors.initials: I
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Sassa
authors.forename: Y
authors.initials: Y
authors.lastname: Natori
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D002645:Chickens; D005895:Gizzard, Avian / Q000254:growth & development / Q000378:metabolism; D006321:Heart / Q000254:growth & development; D006609:High Mobility Group Proteins / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000254:growth & development / Q000378:metabolism; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D006609:High Mobility Group Proteins; D012333:RNA, Messenger