title: Germ-line p53 mutation is uncommon in patients with triple primary cancers.
abstract: We examined five patients with multiple primary cancers who had a history of three different types of primary cancers for germ-line p53 mutations. The germ-line p53 mutation was detected in a patient who conformed to the Li-Fraumeni syndrome, but not in the other four patients. The diagnosis of these four patients did not fall in the category of Li-Fraumeni syndrome. This result indicates that germ-line p53 mutations are uncommon even in patients with triple primary cancers.
authors.affiliation: Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shiseki
authors.forename: R
authors.initials: R
authors.lastname: Nishikawa
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: A
authors.initials: A
authors.lastname: Ochiai
authors.forename: H
authors.initials: H
authors.lastname: Sugimura
authors.forename: N
authors.initials: N
authors.lastname: Shitara
authors.forename: Y
authors.initials: Y
authors.lastname: Sameshima
authors.forename: H
authors.initials: H
authors.lastname: Mizoguchi
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
authors.forename: J
authors.initials: J
authors.lastname: Yokota
mesh_terms: D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*