title: Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects.
abstract: Studies were performed to assess the role of combined selenium and iodine deficiency in the etiology of endemic myxedematous cretinism in a population in Zaire. One effect of selenium deficiency may be to lower glutathione peroxidase activity in the thyroid gland, thus allowing hydrogen peroxide produced during thyroid hormone synthesis to be cytotoxic. In selenium-and-iodine-deficient humans, selenium supplementation may aggravate hypothyroidism by stimulating thyroxin metabolism by the selenoenzyme type I iodothyronine 5'-deiodinase. Selenium supplementation is thus not indicated without iodine or thyroid hormone supplementation in cases of combined selenium and iodine deficiencies.
authors.affiliation: Cemubac Medical Team, Public Health School, Free University of Brussels, Belgium.
authors.forename: J B
authors.initials: JB
authors.lastname: Vanderpas
authors.forename: B
authors.initials: B
authors.lastname: Contempré
authors.forename: N L
authors.initials: NL
authors.lastname: Duale
authors.forename: H
authors.initials: H
authors.lastname: Deckx
authors.forename: N
authors.initials: N
authors.lastname: Bebe
authors.forename: A O
authors.initials: AO
authors.lastname: Longombé
authors.forename: C H
authors.initials: CH
authors.lastname: Thilly
authors.forename: A T
authors.initials: AT
authors.lastname: Diplock
authors.forename: J E
authors.initials: JE
authors.lastname: Dumont
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000209:etiology*; D015023:Democratic Republic of the Congo; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007223:Infant; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency*; D012643:Selenium / Q000009:adverse effects / Q000172:deficiency* / Q000627:therapeutic use; D013974:Thyroxine / Q000097:blood / Q000172:deficiency*
chemical_list: D007455:Iodine; D005979:Glutathione Peroxidase; D012643:Selenium; D013974:Thyroxine