Lung tumors in strain A mice: application for studies in cancer chemoprevention.
Strain A mice develop a high incidence of spontaneous lung tumors during their lifetime. These tumors may be found in some animals as early as 3 to 4 weeks of age, increasing to nearly 100% by 24 months of age. The strain A mouse is also highly susceptible to the induction of lung tumors by several classes of chemical carcinogens and has been used extensively as a mouse lung tumor bioassay for assessing the carcinogenic activity of a variety of chemicals. In addition to its use in carcinogen detection, the strain A mouse lung tumor model has been employed extensively for the identification of inhibitors of chemical carcinogenesis. A number of chemopreventive agents including beta-naphthoflavone, butylated hydroxyanisole, ellagic acid, phenethyl isothiocyanate, phenylpropyl isothiocyanate, phenylbutyl isothiocyanate, phenylhexyl isothiocyanate, indole-3-carbinol, etc., have been shown to inhibit chemically induced lung tumors in strain A mice. In most instances, inhibition of lung tumorigenesis has been correlated with effects of the chemopreventive agent on the metabolic activation and/or detoxification of carcinogens. To date, no chemopreventive agent has been shown to inhibit lung tumorigenesis in strain A mice when administered after the carcinogen, i.e., during the promotion/progression stages of tumor development. Efforts should be made to develop a standardized protocol in strain A mice for evaluating chemopreventive agents as inhibitors of both the initiation and progression stages of lung tumor development.
Stoner
G D
GD
Ohio State University, Department of Preventive Medicine, Arthur G. James Cancer Hospital and Research Institute, Columbus 43210.
Adam-Rodwell
G
G
Morse
M A
MA
D000704:Analysis of Variance; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005260:Female; D017879:Isothiocyanates / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D008745:Methylation; D051379:Mice
D016588:Anticarcinogenic Agents; D017879:Isothiocyanates; C037152:isothiocyanic acid; C058305:phenethyl isothiocyanate; D004247:DNA