Histochemical and contractile property changes during human muscle development.
When the histochemical and contractile properties of infant muscles change postnatally, and what influence muscle function has on these changes, were the focus of this study. Contractile properties were measured in the plantaflexor (PF) and dorsiflexors (DF) of 19 newborns and 36 infants aged 5-16 months. Infants were tested between one and four times at monthly intervals. Measurements included maximal twitch tension (Pt), time to peak tension (TPT), and half-relaxation times (1/2RT). TPT was similar in PF (77 ms) and DF (73 ms) at birth, remained unchanged in DF, and slowed in PF to 110-120 ms between 9 and 12 months. Type I distributions were determined at autopsy in fetal through to adult muscles. Completion of differentiation occurred in soleus at about the age that contractile properties slowed and infants started to use these muscles more. A trend of higher percentages of type I distributions was also noted in children than either newborns or adults in other muscles. The implications of these findings and the clinical use of these methods for evaluating peripheral neuromuscular function is discussed.
Elder
G C
GC
Division of Kinesiology, Dalhousie University, Halifax, Nova Scotia, Canada.
Kakulas
B A
BA
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005333:Fetus; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009048:Motor Skills / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D024510:Muscle Development; D009126:Muscle Relaxation / Q000502:physiology; D009132:Muscles / Q000196:embryology / Q000502:physiology / Q000648:ultrastructure; D009210:Myofibrils / Q000502:physiology / Q000648:ultrastructure; D011187:Posture / Q000502:physiology; D016138:Walking / Q000502:physiology; D016474:Weight-Bearing / Q000502:physiology