title: Quick diagnosis of hyperthyroidism with semiquantitative 30-minute technetium-99m-methoxy-isobutyl-isonitrile thyroid uptake.
abstract: Ten normal volunteers and 14 patients with hyperthyroidism had pinhole thyroid imaging 30 min after an intravenous injection of 10 mCi 99mTc-MIBI. Technetium-99m-MIBI thyroid uptake was calculated by the formula: [total counts with a region of interest (ROI) over the whole thyroid gland] divided by [(mean counts of every pixel in the neck soft tissue) x (total number of pixels in ROI over the whole thyroid gland)]. The results showed that the 30 min 99mTc-MIBI thyroid uptake ratios had positive relationships with the 24 hr 131I-thyroid uptake (r = 0.79), and that the patients with hyperthyroidism had significantly higher 30 min 99mTc-MIBI thyroid uptake than the normal volunteers (5.31 +/- 0.78 s.e.m. versus 2.35 +/- 0.14 s.e.m., p < 0.005 using the Mann-Whitney U-test). Technetium-99m-MIBI thyroid uptake may be useful for the rapid diagnosis of hyperthyroidism.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: S Q
authors.initials: SQ
authors.lastname: Liao
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging*; D008297:Male; D008722:Methods; D008875:Middle Aged; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013961:Thyroid Gland / Q000000981:diagnostic imaging*
chemical_list: D017256:Technetium Tc 99m Sestamibi