title: A familial syndrome with cutaneous malignant melanoma and cerebral astrocytoma.
abstract: We describe a family in which cutaneous malignant melanoma or cerebral astrocytoma, or both, developed in eight members over three generations. Other malignancies also occurred with a lesser frequency. In two patients with both malignant melanoma and astrocytoma, the brain tumor followed the diagnosis of melanoma by a period of 2 and 10 years and was the primary cause of morbidity and mortality. The findings in this family may represent a newly described genetic disorder.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905.
authors.forename: D K
authors.initials: DK
authors.lastname: Kaufman
authors.forename: D W
authors.initials: DW
authors.lastname: Kimmel
authors.forename: J E
authors.initials: JE
authors.lastname: Parisi
authors.forename: V V
authors.initials: VV
authors.lastname: Michels
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008545:Melanoma / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D012878:Skin Neoplasms / Q000150:complications / Q000235:genetics*; D013577:Syndrome