title: Regression of Barrett's esophagus by laser ablation in an anacid environment.
abstract: Consistent regression of intestinal metaplasia in Barrett's esophagus has not been achieved with medical or surgical interventions. In this case report, a patient with Barrett's esophagus of stable length had half the circumference of the Barrett's epithelium ablated with laser therapy while on a high-dose proton-pump inhibitor. In the absence of esophageal acid exposure and after laser ablation, the intestinal metaplasia was documented to reepithelialize with normal squamous mucosa, which has persisted.
authors.affiliation: Department of Internal Medicine, University of Arizona Health Sciences Center, Tucson.
authors.forename: R E
authors.initials: RE
authors.lastname: Sampliner
authors.forename: L J
authors.initials: LJ
authors.lastname: Hixson
authors.forename: M B
authors.initials: MB
authors.lastname: Fennerty
authors.forename: H S
authors.initials: HS
authors.lastname: Garewal
mesh_terms: D000368:Aged; D001471:Barrett Esophagus / Q000473:pathology / Q000628:therapy*; D001706:Biopsy; D003131:Combined Modality Therapy; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology / Q000601:surgery*; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008679:Metaplasia / Q000473:pathology / Q000628:therapy; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery; D009853:Omeprazole / Q000627:therapeutic use*; D012074:Remission Induction
chemical_list: D009853:Omeprazole