title: Brain uptake of thallium-201 from the cerebrospinal fluid compartment.
abstract: The present report elucidates the movement of 201Tl through the cerebrospinal fluid compartment and its subsequent uptake by normal brain. Autoradiographic studies of rat brain, after stereotaxic 201Tl injection into either the lateral or fourth ventricle, reveal that 201Tl moves freely through the cerebrospinal and extracellular fluid compartments. Subsequent to lateral ventricular injection, central thalamic and specific hypothalamic nuclei are heavily labeled. Densely labeled mesencephalic nuclei include the periaqueductal grey and oculomotor nuclear complex. Labeling of giant cells within the vestibular complex is suggestive of neuronal uptake. Major fiber tracts are devoid of label confirming that 201Tl uptake does not occur in white matter. Most labeling following fourth ventricle injection occurs within the caudal medulla and cervical spinal grey. Our findings suggest that 201Tl uptake by normal brain from the cerebrospinal fluid occurs as a function of thallium concentration and neuronal activity.
authors.affiliation: Department of Radiation Oncology and Nuclear Medicine, Hahnemann University School of Medicine, Philadelphia, PA 19102-1192.
authors.forename: J A
authors.initials: JA
authors.lastname: Rubertone
authors.forename: D V
authors.initials: DV
authors.lastname: Woo
authors.forename: J G
authors.initials: JG
authors.lastname: Emrich
authors.forename: L W
authors.initials: LW
authors.lastname: Brady
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000000981:diagnostic imaging*; D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging* / Q000502:physiology; D007276:Injections, Intraventricular; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D013794:Thallium Radioisotopes / Q000008:administration & dosage
chemical_list: D013794:Thallium Radioisotopes