title: [A field study of the efficacy of ivermectin in propylene glycol in the treatment of mange in guinea pigs].
abstract: The clinical manifestation of mange in a guinea-pig population in Utrecht is discussed. The etiology and the treatment with two subcutaneous injections of ivermectin 0.2 mg/kg with a ten-day interval, is described. A total of 37 guinea-pigs with symptoms and 36 guinea-pig without signs of mange were treated. On the 21st day all previously infested guinea-pigs were free of symptoms. During this study side-effects occurred in 11 of the 73 animals. The most prominent side-effects were a (sub-)dermal necrosis in the younger animals and an inflammation of the cutis in the older animals. The side-effects were probably caused by propylene glycol which was used as a diluent.
authors.affiliation: Vakgroep Geneeskunde Gezelschapsdieren, Faculteit Diergeneeskunde, Utrecht.
authors.forename: P J
authors.initials: PJ
authors.lastname: Mandigers
authors.forename: M H
authors.initials: MH
authors.lastname: van der Hage
authors.forename: I
authors.initials: I
authors.lastname: Westerhof
authors.forename: G M
authors.initials: GM
authors.lastname: Dorrestein
mesh_terms: D000818:Animals; D004337:Drug Carriers; D006168:Guinea Pigs / Q000469:parasitology*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D009336:Necrosis; D011409:Propylene Glycols / Q000009:adverse effects; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*; D012867:Skin / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D011409:Propylene Glycols; D007559:Ivermectin