title: Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testing.
abstract: The authors assessed the relationship between ventricular enlargement, cortical atrophy, regional brain glucose metabolism, and neuropsychologic performance in 10 alcoholics and 10 control subjects. Regional brain glucose metabolism was measured with fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET). Cortical atrophy and ventricular size were evaluated quantitatively with magnetic resonance (MR) imaging. Alcoholics had decreased brain glucose metabolism and more cortical atrophy but did not have significantly greater ventricular size than did control subjects. The degree of ventricular enlargement and of cortical atrophy was associated with decreased metabolism predominantly in the frontal cortices and subcortical structures in both alcoholics and control subjects. There were no significant correlations between neuropsychologic performance and MR imaging structural changes, whereas various subtest scores were significantly correlated with frontal lobe metabolism. These data show that F-18 FDG PET is a sensitive technique for detecting early functional changes in the brain due to alcohol and/or aging before structural changes can be detected with MR imaging.
authors.affiliation: Medical Department, Brookhaven National Laboratory, Upton, NY 11973.
authors.forename: G J
authors.initials: GJ
authors.lastname: Wang
authors.forename: N D
authors.initials: ND
authors.lastname: Volkow
authors.forename: C T
authors.initials: CT
authors.lastname: Roque
authors.forename: V L
authors.initials: VL
authors.lastname: Cestaro
authors.forename: R J
authors.initials: RJ
authors.lastname: Hitzemann
authors.forename: E L
authors.initials: EL
authors.lastname: Cantos
authors.forename: A V
authors.initials: AV
authors.lastname: Levy
authors.forename: A P
authors.initials: AP
authors.lastname: Dhawan
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000523:psychology; D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012016:Reference Values; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose