title: Parental age, genetic mutation, and cerebral palsy.
abstract: Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
authors.affiliation: Department of Neurological Sciences, St Bartholomew's Hospital, London.
authors.forename: N A
authors.initials: NA
authors.lastname: Fletcher
authors.forename: J
authors.initials: J
authors.lastname: Foley
mesh_terms: D000293:Adolescent; D000328:Adult; D001264:Athetosis; D001722:Birth Order; D002547:Cerebral Palsy / Q000145:classification / Q000235:genetics* / Q000473:pathology; D004421:Dystonia; D005799:Genes, Dominant; D006429:Hemiplegia; D006801:Humans; D007231:Infant, Newborn; D008423:Maternal Age; D008875:Middle Aged; D009154:Mutation; D010243:Paralysis; D010331:Paternal Age; D011782:Quadriplegia