title: In vivo transport and excretion of corrosion products from accelerated anodic corrosion of porous coated F75 alloy.
abstract: Corrosion of porous coated cobalt chromium specimens surgically implanted subcutaneously in hamsters was accelerated by application of a fixed anodic potential. Corrosion current measurements were utilized for prediction of metal ion release based on Faraday's law. Daily urine samples were collected pre- and post-stimulation, and, at animal sacrifice, organs and blood samples were taken for chemical analysis. By using in vitro release data from previous studies, and efficiency correction factors, the amount of metal ion release was calculated. The results demonstrated rapid and complete excretion of nickel and molybdenum. Most of the cobalt was excreted, with elevation of cobalt levels in liver, kidney, and lung. Chromium excretion was much lower due to significant red cell binding and in vivo storage, especially in the kidney and spleen.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207.
authors.forename: S A
authors.initials: SA
authors.lastname: Brown
authors.forename: K
authors.initials: K
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Merritt
authors.forename: J H
authors.initials: JH
authors.lastname: Payer
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000493:pharmacokinetics*; D001693:Biological Transport, Active; D002857:Chromium / Q000493:pharmacokinetics / Q000652:urine; D002858:Chromium Alloys / Q000493:pharmacokinetics*; D003035:Cobalt / Q000493:pharmacokinetics / Q000652:urine; D003343:Corrosion; D006224:Cricetinae; D008422:Materials Testing; D008647:Mesocricetus; D008982:Molybdenum / Q000493:pharmacokinetics / Q000652:urine; D009532:Nickel / Q000493:pharmacokinetics / Q000652:urine; D019736:Prostheses and Implants; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D002858:Chromium Alloys; D002857:Chromium; D003035:Cobalt; D009532:Nickel; D008982:Molybdenum