[The hormonal regulation of bile secretion due to the activation of protein biosynthesis in the hepatocytes].
The enhanced bile secretion induced by hydrocortisone coincides in time with activation of the biosynthesis of intracellular and export proteins of the liver. Preliminary inhibition of the protein biosynthesis in the hepatocytes hinders the development of hypercholeretic effects of hydrocortisone or considerably distorts them. The activation of the protein biosynthesis in the liver cells is one of the main molecular mechanisms of choleretic action of glycocorticoids and a number of other hormones.
Masiuk
A I
AI
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D011506:Proteins / Q000037:antagonists & inhibitors / Q000187:drug effects*; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors
D011506:Proteins; D003609:Dactinomycin; D011691:Puromycin; D003513:Cycloheximide; D006854:Hydrocortisone