Mapping of the human adenylosuccinate lyase (ADSL) gene to chromosome 22q13.1-->q13.2.
Adenylosuccinate lyase (ADSL) is an essential enzyme involved in de novo purine biosynthesis. A deficiency in ADSL in humans has been shown to predispose to a neurodevelopmental syndrome with autistic features. Using both a somatic cell hybrid mapping panel and fluorescence in situ hybridization, we have precisely localized the human ADSL gene to chromosome 22q13.1-->q13.2.
Fon
E A
EA
Montreal General Hospital Research Institute, McGill University, Québec, Canada.
Demczuk
S
S
Delattre
O
O
Thomas
G
G
Rouleau
G A
GA
D000264:Adenylosuccinate Lyase / Q000235:genetics*; D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D012377:Rodentia
D000264:Adenylosuccinate Lyase