title: [Clinical aspects of screening and diagnosis of congenital hypothyroidism in neonates in Moscow].
abstract: Screening of the newborns helped diagnose congenital hypothyrosis in infants of Moscow and define its incidence as 1 per 5000 newborns. Seventeen newborns (20%) with congenital hypothyrosis were detected among 65 ones with positive tests of more than 5 microU/ml. Clinical manifestations of this disease may be detected by specialists within the first weeks of life. Blood TTH level higher than 100 microU/ml is an evidence of congenital hypothyrosis, though one case with a lower TTH level in a newborn was detected. Levothyroxine therapy in a daily dose 50 micrograms is the optimal for the majority of such patients. For infants with transitory hypothyrosis with blood TTH levels from 40 to 80 micrograms/ml short levothyroxine therapy courses in daily doses 25-50 micrograms for 2-3 weeks may be recommended to preserve the intellectual potential of the child. All the children with blood TTH levels higher than 20 microU/ml should be regularly examined by endocrinologists and neuropathologists starting from the first days of life.
authors.forename: I A
authors.initials: IA
authors.lastname: Vasilevskaia
authors.forename: G G
authors.initials: GG
authors.lastname: Guzeev
authors.forename: A D
authors.initials: AD
authors.lastname: Baĭkov
authors.forename: I A
authors.initials: IA
authors.lastname: Rykina
authors.forename: V B
authors.initials: VB
authors.lastname: Bugrova
mesh_terms: D003409:Congenital Hypothyroidism; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D015994:Incidence; D007231:Infant, Newborn; D009031:Moscow / Q000453:epidemiology; D015997:Neonatal Screening; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013972:Thyrotropin; D013974:Thyroxine