Ten and ninety-day toxicity studies of 2-chlorophenol in Sprague-Dawley rats.
Male and female Sprague-Dawley rats received 2-chlorophenol in corn oil daily by gavage for 10 or 90 consecutive days. The 10-day study doses were 13, 64, 129 and 257 mg/kg while the 90-day subchronic study doses were 17, 50 and 150 mg/kg. In the 10-day study, hematologic and clinical chemistry, food and water consumption, absolute and relative organ weights, and histopathological findings revealed no compound or sex-related effects. In the 90-day study there were no significant gross or histopathological findings that were treatment-related in either sex. There were statistically significant differences between control and treated groups associated with hematology, clinical chemistry and organ weights; however, none of the differences were considered to be biologically meaningful.
Daniel
F B
FB
Ecological Monitoring Research Division, U.S. Environmental Protection Agency, Cincinnati, Ohio 45268.
Robinson
M
M
Olson
G R
GR
York
R G
RG
Condie
L W
LW
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002733:Chlorophenols / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D013997:Time Factors; D014881:Water Supply
D001786:Blood Glucose; D002733:Chlorophenols; C030683:2-chlorophenol