title: The effects of high and low BACs on the Hoffmann reflex.
abstract: The purpose of this study was to measure and assess the magnitude and latency of the H-reflex and M-response between pre- and post-alcohol consumption. Also of interest was the comparison of the H-reflex and M-response between the rising and falling curves of BAC. Seven male volunteer subjects participated in this study. Testing started with pre-alcohol BAC and EMG recordings from the tibial nerve following an electrical stimulation. After alcohol consumption, BAC readings were obtained every five minutes, and the EMGs were recorded at the following BAC levels (in mg/dl): 75, 100, and falling 75. H-latency, H-amplitude, and M-response were identified within the EMG signals. The analysis focused on the comparisons of these measures between each of the BAC levels and the baseline, as well as between the rising and falling BACs. Results showed that, overall, the H-reflex and M-response were depressed following alcohol consumption. In addition, the depression of H-reflex appeared to be greater during the rising curve than the falling curve.
authors.affiliation: Health & Human Performance Studies, University of Alabama, Tuscaloosa 35487.
authors.forename: M Q
authors.initials: MQ
authors.lastname: Wang
authors.forename: M E
authors.initials: ME
authors.lastname: Nicholson
authors.forename: B S
authors.initials: BS
authors.lastname: Mahoney
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: E C
authors.initials: EC
authors.lastname: Fitzhugh
authors.forename: J
authors.initials: J
authors.lastname: Shea
mesh_terms: D000293:Adolescent; D000328:Adult; D000344:Afferent Pathways / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004525:Efferent Pathways / Q000187:drug effects; D004576:Electromyography; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006181:H-Reflex / Q000187:drug effects*; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D012021:Reflex, Abnormal / Q000187:drug effects*
chemical_list: D000431:Ethanol