Molecular determinants of the alpha-2D adrenergic receptor subtype.
The alpha-2 adrenergic receptor in the bovine pineal gland and the rodent homologues of the human alpha-2-C10 receptor express alpha-2D subtype pharmacological characteristics. The alpha-2 adrenergic receptor in the chicken pineal expresses characteristics similar to the alpha-2A subtype found in human and pig. The rodent receptors (alpha-2D) contain a serine residue at position 201 whereas the human and porcine receptors (alpha-2A) have a cysteine at this position. Our results indicate that the bovine pineal receptor has a serine at position 201, supporting the alpha-2D classification. However, the chicken pineal receptor also contains a serine at position 201 suggesting that other amino acids may be responsible for the differences in pharmacological characteristics.
Blaxall
H S
HS
Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198-6260.
Heck
D A
DA
Bylund
D B
DB
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002645:Chickens; D003545:Cysteine / Q000737:chemistry; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000737:chemistry / Q000145:classification*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D012694:Serine / Q000737:chemistry; D013329:Structure-Activity Relationship
D018341:Receptors, Adrenergic, alpha-2; D012694:Serine; D003545:Cysteine