title: Hypercalcemia in the blastic phase of chronic myeloid leukemia associated with elevated parathyroid hormone-related protein.
abstract: We describe a case of hypercalcemia without lytic bone lesions complicating myeloid blast crisis of chronic myeloid leukemia (CML). Serum levels of parathyroid hormone-related protein (PTHrP) were elevated during the initial hypercalcemic period and became undetectable during chemotherapy-induced chronic phase, only to become elevated again during subsequent recurrent blastic periods repeatedly associated with hypercalcemia. Previously reported cases of hypercalcemia complicating CML are reviewed. It is suggested that PTHrP was responsible for the hypercalcemia in this case and may be an important mediator of hypercalcemia in CML.
authors.forename: J F
authors.initials: JF
authors.lastname: Seymour
authors.forename: V
authors.initials: V
authors.lastname: Grill
authors.forename: T J
authors.initials: TJ
authors.lastname: Martin
authors.forename: N
authors.initials: N
authors.lastname: Lee
authors.forename: F
authors.initials: F
authors.lastname: Firkin
mesh_terms: D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood* / Q000209:etiology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood* / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*; D014170:Transformation, Genetic
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins