Debrisoquine hydroxylase and Parkinson's disease.
The relationship between the genotypes of Xba I and Bam H I restriction fragment length polymorphisms (RFLPs) at a gene for debrisoquine hydroxylase (CYP2D6) and phenotypes of the metabolic function of debrisoquine/sparteine, the EM and the PM in a healthy Japanese population was investigated. The genotypes of Xba I 11.5 kb and Xba I 44 kb-Bam H I 2.3 kb- were responsible for the Japanese PM. Genotype of Xba I RFLP at CYP2D6 locus was analyzed in 43 healthy individuals and 51 patients with IDP. The relative risk of IDP was 2.15 times more for individuals with the Xba I 44 kb allele compared to those without the allele (chi 2 = 4.149, d.f. = 1, p < 0.05) and it was 6.32 times greater for the Xba I 44 kb homozygotes than the Xba I 29 kb homozygotes (chi 2 = 4.935, d.f. = 1, p < 0.05). These data suggest that the PM for debrisoquine/sparteine hydroxylase might be one of the genetic factors making humans susceptible to IDP acquisition.
Kondo
I
I
Department of Human Ecology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Kanazawa
I
I
D001345:Autoradiography; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D003001:Cloning, Molecular; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000502:physiology; D005808:Genes, Recessive / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007564:Japan; D006899:Mixed Function Oxygenases / Q000235:genetics* / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology; D010641:Phenotype; D012307:Risk Factors; D013034:Sparteine / Q000493:pharmacokinetics
D013034:Sparteine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6