title: [Theoretical analysis of some features of compensatory substitution in stem regions of transport RNA].
abstract: Some families of isoacceptor tRNAs were studies using VOSTORG software package for phylogenetic analysis. While analysing the evolutionary trees in was shown that the fixation of double substitutions AU<-->GC in spiral double-stranded regions passes two stages with intermediate station, such as non-canonical base pairs. In all the families studied double substitutions can be explained not only by passages through slightly deleterious GU pairs. Comparative analysis of B2-like repeats shown the absence of compensatory substitutions in the parts which are homologous to RNA stem regions. The data obtained let us assume that compensatory substitutions in the RNA helical regions represent an expressive example of non-directed adaptive molecular coevolution.
authors.forename: S N
authors.initials: SN
authors.lastname: Rodin
authors.forename: I B
authors.initials: IB
authors.lastname: Kuznetsov
mesh_terms: D000818:Animals; D005075:Biological Evolution; D009690:Nucleic Acid Conformation; D012343:RNA, Transfer / Q000737:chemistry*; D012091:Repetitive Sequences, Nucleic Acid; D012377:Rodentia
chemical_list: D012343:RNA, Transfer