title: Problems with stopping rules in the trials of risky therapies: the case of warfarin to prevent stroke in atrial fibrillation.
authors.affiliation: General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114.
authors.forename: D E
authors.initials: DE
authors.lastname: Singer
mesh_terms: D001281:Atrial Fibrillation / Q000188:drug therapy*; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D036302:Therapeutic Human Experimentation; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D014859:Warfarin