[The lipid lowering effect of a new guar-pectin fiber mixture in type II diabetic patients with hypercholesterolemia].
The lipid-lowering effect of a new mixture of fiber consisting in guar and apple-pectin in combination with apple-pomaces has been estimated in 15 female type 2-diabetics [age mean = 62 (52-70) yr] with hypercholesterolemia (total-chol > 240 mg/dl and LDL-chol > 130 mg/dl). After a dietetic run-in-phase of 3 weeks the patients received the fiber mixture (1 package of 17 g with about 5.9 g water-soluble fiber) dissolved in 250 ml water for the next 9 weeks: during the first 3 weeks 2 portions per day, the next 3 weeks twice 1/2 portion and the last 3 weeks one 1/2 portion daily. The fiber mixture had to been consumed 30 minutes before taking a main meal. Regular intake of the fiber product led to a significant decrement in blood lipids, and this improvement under 2 portions daily has been maintained for the most part with the reduced dosage. The total-chol levels decreased by 11.3% during the first 3 weeks of fiber intake (p < 0.05) and by -12.6% during the next 3 weeks (p < 0.05), the decrease during the last 3 weeks under the reduced fiber intake was -9.6% (ns). The HDL-chol levels remained approximately the same during the whole period of observation. The triglyceride concentrations in serum could be lowered by -15.5% during the first 3 weeks of fiber intake, and by -19.2% during the next 3 weeks (p < 0.05), finally the decrease was -12.3% (ns). The atherogenic index (Chol-/HDL-chol) could be reduced on an average of 14.3% in relation to the initial value.(ABSTRACT TRUNCATED AT 250 WORDS)
Biesenbach
G
G
II. Medizinische Abteilung, Allgemeinen Krankenhauses Linz.
Grafinger
P
P
Janko
P
P
Kaiser
W
W
Stuby
U
U
Moser
E
E
D000368:Aged; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D003927:Diet, Diabetic; D004043:Dietary Fiber; D004338:Drug Combinations; D005260:Female; D005685:Galactans / Q000008:administration & dosage*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008351:Mannans / Q000008:administration & dosage*; D008875:Middle Aged; D010368:Pectins / Q000008:administration & dosage*; D053149:Plant Gums; D014280:Triglycerides / Q000097:blood
D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D004338:Drug Combinations; D005685:Galactans; D006442:Glycated Hemoglobin; D008351:Mannans; D010368:Pectins; D053149:Plant Gums; D014280:Triglycerides; C007894:guar gum