[Effect of Schistosoma japonicum infection on liver drug-metabolizing enzymes of mice].
In this paper, the effect of Schistosoma japonicum infection on liver drug-metabolizing enzymes of mice was studied. The prolongation of hypnosis duration of sodium pentobarbital in vivo and the inhibition of liver aniline hydroxylase (AH), aminopyrine N-demethylase (APD) as well as cytochrome P-450 (Cyt P-450) in vitro were observed in mice infected with 20, 40 and 60 cercariae of S. japonicum after 6 weeks. Meanwhile, with 30 cercariae infection, no significant inhibition of the activity of AH, APD and Cyt P-450 was observed in mice 4 weeks after infection, but significant inhibition of these enzymes was shown by 8 weeks. As compared with control, the activity of AH, APD and Cyt P-450 decreased to 32.6%, 13.7% and 7.7% at 8 weeks. The results indicate that infection of S. japonicum can inhibit the liver drug-metabolizing capacity of mice, and the degree of inhibition depends on the infectivity and the duration of infection.
Wang
J
J
Institute of Antiparasitic Diseases, Sichuan Academy of Medical Sciences, Chengdu.
Qiu
Z Y
ZY
Xie
W
W
Wu
Y Y
YY
D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D010424:Pentobarbital / Q000378:metabolism; D012554:Schistosomiasis japonica / Q000201:enzymology*
D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D010424:Pentobarbital