Chromosomal mapping of genetic locus associated with thymus-size enlargement in BUF/Mna rats.
The thymoma-prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr-1. At pre-thymoma age, BUF/Mna rats have extremely large thymuses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten-1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten-1 and microsatellite markers in backcross rats of (WKY/NCrj x BUF/Mna)F1 x BUF/Mna have led to the localization of Ten-1 in chromosome 1. This result may provide an approach to clone Tsr-1, which could be allelic to Ten-1.
Murakumo
Y
Y
Department of Pathology, Nagoya University School of Medicine.
Takahashi
M
M
Arakawa
A
A
Saito
M
M
Amo
H
H
Katoh
H
H
Matsuyama
M
M
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005819:Genetic Markers; D051381:Rats; D011915:Rats, Inbred BUF / Q000235:genetics*; D011921:Rats, Inbred WKY / Q000235:genetics*; D013950:Thymus Gland / Q000254:growth & development*
D005819:Genetic Markers