Meta-iodobenzylguanidine (MIBG) scanning in the diagnosis of phaeochromocytoma.
During the period 1984-90, meta-iodobenzylguanidine (MIBG) scans were performed in 23 patients with suspected phaeochromocytoma seen at the Hammersmith Hospital. Sixteen patients had a histologically proven phaeochromocytoma and in 14 of these patients the tumour was demonstrated by abnormal uptake of MIBG. Seven patients did not have a phaeochromocytoma and in all of these the MIBG scan was negative. These findings gave the procedure a sensitivity of 87.5% with a specificity of 100%; positive and negative predictive values were 100% and 77.7%, respectively. MIBG scanning is an extremely valuable technique in the management of patients with suspected phaeochromocytoma but is best employed to localise a tumour which has been confirmed biochemically.
Clesham
C J
CJ
Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Kennedy
A
A
Lavender
J P
JP
Dollery
C T
CT
Wilkins
M R
MR
D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002395:Catecholamines / Q000097:blood; D003287:Contrast Media; D005260:Female; D006801:Humans; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D010425:Pentolinium Tartrate; D010673:Pheochromocytoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D014642:Vanilmandelic Acid / Q000652:urine
D002395:Catecholamines; D003287:Contrast Media; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D014642:Vanilmandelic Acid; D010425:Pentolinium Tartrate