An adult case of Fanconi syndrome due to a mixture of Chinese crude drugs.
We examined a 35-year-old male case of acquired Fanconi syndrome induced by a mixture of Chinese crude drugs. Renal glycosuria, hypokalemia, hypophosphatemia, metabolic acidosis, a low threshold of tubular bicarbonate excretion, and generalized aminoaciduria were observed after the patient had taken the drugs for 6 months. When he stopped taking them, all laboratory data improved. He took the drugs again on his own judgment, leading to a second bout of Fanconi syndrome. This is the first case in which Chinese crude drugs have been known to cause acquired Fanconi syndrome.
Izumotani
T
T
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Ishimura
E
E
Tsumura
K
K
Goto
K
K
Nishizawa
Y
Y
Morii
H
H
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D006034:Glycyrrhetinic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D019695:Glycyrrhizic Acid; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000201:enzymology; D008297:Male; D011379:Prognosis; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D004365:Drugs, Chinese Herbal; D019695:Glycyrrhizic Acid; D000254:Sodium-Potassium-Exchanging ATPase; D006034:Glycyrrhetinic Acid