title: Acquired resistance to Schistosoma japonicum in IgE-deficient SJA/9 mice immunized with irradiated cercariae.
abstract: Participation of IgE in protective immunity against Schistosoma japonicum was examined by comparing congenital IgE-deficient SJA/9 and IgE-producing SJL/J mice. Mice immunized with 100 irradiated cercariae 7 weeks previously were infected with 50 live cercariae. In SJL/J mice at 40 days after infection, a 3-to 4-fold increase of total IgE levels and anti-S, japonicum egg IgE antibody production were observed with no significant difference between immunized and nonimmunized mice. IgE was not detected in SJA/9 mice throughout the experiments. Protective immunity evaluated by recovery of adult worms was found in SJA/9 mice and was comparable to that of SJL/J mice. These results suggest that acquired immunity in mice with irradiated cercariae of S. japonicum was not dependent on IgE in these strains of mice.
authors.affiliation: Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Janecharut
authors.forename: S
authors.initials: S
authors.lastname: Kojima
authors.forename: Z
authors.initials: Z
authors.lastname: Ovary
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000276:immunology*; D005260:Female; D007113:Immunity, Innate; D007114:Immunization; D007073:Immunoglobulin E / Q000172:deficiency*; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008817:Mice, Mutant Strains; D051381:Rats; D017208:Rats, Wistar; D012549:Schistosoma japonicum / Q000276:immunology* / Q000528:radiation effects; D012554:Schistosomiasis japonica / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G; D007073:Immunoglobulin E