The neuropharmacological restoration of cognitive functions of cats following a lesion to the basal nuclei of the forebrain (Meynert's nucleus).
The functions of generalization and abstraction in an experimental model of Alzheimer's disease (the lesion of Meynert's nuclei in cats) were studied against the background of stimulation and inhibition of the cholinergic, GABAergic, and dopaminergic systems of the brain. It was demonstrated that the cholinergic system is a key system for the formation of the function of generalization, the dopaminergic system improves simple forms of learning, while the GABAergic system is actively involved in the establishment of complex types of associations.
Mukhin
E I
EI
Institute of the Brain, Academy of Medical Sciences, Moscow.
Nabieva
T N
TN
Mukhina YuK
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002415:Cats; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects; D004298:Dopamine / Q000502:physiology; D005260:Female; D005795:Generalization, Stimulus / Q000187:drug effects; D007051:Ibotenic Acid / Q000633:toxicity; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D011340:Problem Solving / Q000187:drug effects; D013377:Substantia Innominata / Q000033:anatomy & histology / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D010276:Parasympatholytics; D007051:Ibotenic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D004298:Dopamine