Acute myelomonocytic leukemia in a XYY man.
A case of acute myeloid leukemia (M4) in a 29-year-old male with a 47,XYY karyotype is reported. This aneuploidy was found in both bone marrow cells and mitogen-stimulated lymphocytes. Monosomy 7 correlated with myelodysplastic features. The possible role of XYY in increasing the risk of leukemia is discussed.
Bauduer
F
F
Department of Hematology, Hôtel-Dieu, Paris, France.
Ramond
S
S
Delmer
A
A
Delmas-Marsalet
B
B
Viguié
F
F
Dadoune
J P
JP
Zittoun
R
R
D000328:Adult; D005602:France; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D011174:Portugal / Q000208:ethnology; D014997:XYY Karyotype