[Recent advances in lipoprotein metabolism].
Recent advances in lipoprotein metabolism were reviewed. The scavenger receptor for acetyl-LDL cloned by Kodama et al. was immunohistochemically demonstrated to exist in the human atherosclerotic lesions. LDL-receptor related protein (LRP) and VLDL receptor which would recognize apoE but not apoB have been recently cloned. Transgenic mice expressing high levels of apolipoproteins such as apoA-I and apoE or apolipoprotein deficient mice produced by gene targetting technique are providing important information on the function of apolipoproteins.
Miyazaki
A
A
Biochemistry II, Kumamoto University School of Medicine.
Horiuchi
S
S
D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism*; D005818:Genetic Engineering; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D018110:Receptors, Lipoprotein / Q000378:metabolism*
D016632:Apolipoprotein A-I; D001057:Apolipoproteins E; D008074:Lipoproteins; D018110:Receptors, Lipoprotein