Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints.
A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.
Sinke
R J
RJ
Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
de Leeuw
B
B
Janssen
H A
HA
Weghuis
D O
DO
Suijkerbuijk
R F
RF
Meloni
A M
AM
Gilgenkrantz
S
S
Berger
W
W
Ropers
H H
HH
Sandberg
A A
AA
D000818:Animals; D015139:Blotting, Southern; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002887:Chromosomes, Human, Pair 18; D006224:Cricetinae; D003412:Cricetulus; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D013584:Sarcoma, Synovial / Q000235:genetics*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured; D014960:X Chromosome
D005819:Genetic Markers