Changes in preproenkephalin mRNA after unilateral and bilateral labyrinthectomy in the rat medial vestibular nucleus.
We examined the expression of preproenkephalin (PPE) mRNA in the vestibular nuclei in rats using in situ hybridization histochemistry. In normal rats, PPE mRNA-positive cells were observed in the medial and spinal vestibular nuclei. After unilateral labyrinthectomy, PPE mRNA was increased in the medial vestibular nucleus on the operated side from the 1st through the 3rd day after the surgery. It is suggested that the changes in PPE mRNA level after labyrinthectomy are involved in vestibular compensation.
Saika
T
T
Department of Otolaryngology, Osaka University Medical School, Japan.
Takeda
N
N
Kiyama
H
H
Kubo
T
T
Tohyama
M
M
Matsunaga
T
T
D000818:Animals; D007758:Ear, Inner / Q000502:physiology*; D004745:Enkephalins / Q000235:genetics*; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D014726:Vestibular Nuclei / Q000378:metabolism*
D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; C033660:preproenkephalin