Inhibition of DNA topoisomerase I activity by diethylstilbestrol and its analogues.
Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (+/-)-indenestrol B, (+/-)-IB, showed the strongest inhibitory effect.
Oda
T
T
Kyoritsu College of Pharmacy, Tokyo, Japan.
Sato
Y
Y
Kodama
M
M
Kaneko
M
M
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004054:Diethylstilbestrol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004587:Electrophoresis, Agar Gel; D004926:Escherichia coli / Q000201:enzymology; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology; D007192:Indenes / Q000494:pharmacology*; D013237:Stereoisomerism; D059004:Topoisomerase I Inhibitors
D004968:Estrogens, Non-Steroidal; D007192:Indenes; D059004:Topoisomerase I Inhibitors; C047437:indenestrol; D004054:Diethylstilbestrol