title: Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness.
abstract: T cell receptor (TCR) vaccination in rats prevents the development of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis. The mechanism of this potential immunotherapy was examined by vaccinating mice with an immunogenic peptide fragment of the variable region of the TCR V beta 8.2 gene. Another immunogen that usually induces an immune response mediated by V beta 8.2+ T cells was subsequently inhibited because specific clonal unresponsiveness (anergy) had been induced. Depletion of CD8+ cells before TCR peptide vaccination blocked such inhibition. Thus, the clonal anergy was dependent on CD8+ T cells, and such immunoregulatory T cells may participate in the normal course of EAE.
authors.affiliation: Department of Medicine, Stanford University School of Medicine, CA 94305.
authors.forename: A
authors.initials: A
authors.lastname: Gaur
authors.forename: G
authors.initials: G
authors.lastname: Ruberti
authors.forename: R
authors.initials: R
authors.lastname: Haspel
authors.forename: J P
authors.initials: JP
authors.lastname: Mayer
authors.forename: C G
authors.initials: CG
authors.lastname: Fathman
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D016827:CD8 Antigens / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000517:prevention & control; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014612:Vaccines
chemical_list: D000906:Antibodies; D016827:CD8 Antigens; D011948:Receptors, Antigen, T-Cell; D014612:Vaccines