Cyclophosphamide cardiac injury mimicking acute myocardial infarction.
We report a patient in whom cyclophosphamide (CY) caused damage to the heart that was manifested by ST segment elevation and marked elevation of serum cardiac isoenzymes and mimicked myocardial infarction. Post-mortem examination did not reveal any local vascular event (e.g. thrombus or spasm) and suggested diffuse myocardial injury secondary to CY.
Dow
E
E
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Schulman
H
H
Agura
E
E
D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006321:Heart / Q000187:drug effects*; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D009203:Myocardial Infarction / Q000139:chemically induced*
D003520:Cyclophosphamide