Immunohistopathological spectrum in cutaneous tuberculosis.
Granulomas of lupus vulgaris were characterized by a raised CD4+/CD8+ ratio, while in scrofuloderma this was significantly decreased. Tuberculosis verrucosa cutis showed intermediate changes. These immunological variations suggest that cutaneous tuberculosis forms a spectrum with strong cell-mediated immunity seen in lupus vulgaris, and weaker cell-mediated responses in scrofuloderma; tuberculosis verrucosa cutis is intermediate between the two.
Sehgal
V N
VN
Department of Dermatology, Lady Hardinge Medical College, Delhi, India.
Gupta
R
R
Bose
M
M
Saha
K
K
D015703:Antigens, CD / Q000276:immunology*; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008297:Male; D012867:Skin / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014382:Tuberculosis, Cutaneous / Q000276:immunology*
D015703:Antigens, CD