title: Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6.
abstract: We administered the Karolinska Scales of Personality to 225 healthy subjects in Spain selected from a group of 925 individuals previously phenotyped with regard to their capacity to hydroxylate debrisoquine. A significant relationship was found between the scores in as many as 4 of the 15 subscales (psychic anxiety, psychasthenia, inhibition of aggression and socialization) and the debrisoquine hydroxylation capacity. Poor metabolizers were more anxiety-prone and less successfully socialized than extensive metabolizers of debrisoquine. This and a previous study among subjects in Sweden suggest that there may be a relationship between personality and the activity of the enzyme hydroxylating debrisoquine (cytochrome P4502D6). This polymorphic enzyme may have an endogenous neuroactive substrate or product, such as a biogenic neurotransmitter amine.
authors.affiliation: Department of Clinical Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Llerena
authors.forename: G
authors.initials: G
authors.lastname: Edman
authors.forename: J
authors.initials: J
authors.lastname: Cobaleda
authors.forename: J
authors.initials: J
authors.lastname: Benítez
authors.forename: D
authors.initials: D
authors.lastname: Schalling
authors.forename: L
authors.initials: L
authors.lastname: Bertilsson
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010551:Personality / Q000502:physiology*; D010555:Personality Inventory; D010641:Phenotype
chemical_list: D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D003647:Debrisoquin