Enhanced production of rat interleukin-8 by in vitro and in vivo infections with influenza A NWS virus.
We investigated the interleukin-8 (IL-8)-producing activity of influenza A NWS virus in cultured rat kidney NRK-52E cells and a rat influenza model. The production of rat IL-8 increased significantly in the virus-infected cells but not in UV-inactivated virus- or split-product-treated cells. The increase in IL-8 production could be detected in the bronchoalveolar lavage of infected rats. These data suggest that infectious virus has the potential to accelerate the production of IL-8 in cultured cells and in vivo in airway-lining cells.
Ochiai
H
H
Department of Virology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Ikesue
A
A
Kurokawa
M
M
Nakajima
K
K
Nakagawa
H
H
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002460:Cell Line; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000472:pathogenicity*; D016209:Interleukin-8 / Q000096:biosynthesis*; D008297:Male; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D016209:Interleukin-8