[Molecular and cellular aspects of cis-diamminedichloroplatinum (II) interactions with DNA].
Cis-DDP is an antitumor drug with activity against various human tumors. It is generally accepted that DNA is the cellular target of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eukaryotic systems. We also discuss the possible mechanisms of acquired resistance of cancerous cells to cis-DDP and analogues, and potential clinical implication of this phenomenon.
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Zakład Biochemii Klinicznej Akademii Medycznej, Bydgoszczy.
Oliński
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D000818:Animals; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology*; D004247:DNA; D018736:DNA Adducts; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D004351:Drug Resistance; D006801:Humans; D013237:Stereoisomerism
D018736:DNA Adducts; D004273:DNA, Neoplasm; C057270:cisplatin-DNA adduct; D004247:DNA; D002945:Cisplatin