title: Selenium deficiency, thyroid hormone metabolism, and thyroid hormone deiodinases.
abstract: Much research into the functions of selenium in the cell has concentrated on its role in selenium-containing glutathione peroxidases. However, selenium was recently shown to be an essential component of type I iodothyronine 5'-deiodinase in rats, which converts thyroxin to the more biologically active hormone 3,5,3'-triiodothyronine. Thus, selenium-deficient rats have low tissue deiodinase activities and abnormal thyroid hormone metabolism. The discovery of this function for selenium in thyroid hormone metabolism has important implications for the interpretation of the effects of selenium deficiency, especially in individuals with an adequate vitamin E status.
authors.affiliation: Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, Scotland.
authors.forename: J R
authors.initials: JR
authors.lastname: Arthur
authors.forename: F
authors.initials: F
authors.lastname: Nicol
authors.forename: G J
authors.initials: GJ
authors.lastname: Beckett
mesh_terms: D000818:Animals; D006801:Humans; D007453:Iodide Peroxidase / Q000378:metabolism*; D012643:Selenium / Q000172:deficiency* / Q000502:physiology; D013961:Thyroid Gland / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D007453:Iodide Peroxidase; D012643:Selenium; D013974:Thyroxine