title: Breath acetone analyzer: diagnostic tool to monitor dietary fat loss.
abstract: Acetone, a metabolite of fat catabolism, is produced in excessive amounts in subjects on restricted-calorie weight-loss programs. Breath acetone measurements are useful as a motivational tool during dieting and for monitoring the effectiveness of weight-loss programs. We have developed a simple, easy-to-read method that quantifies the amount of acetone in a defined volume of exhaled breath after trapping the sample in a gas-analyzer column. The concentration of acetone, as measured by the length of a blue color zone in the analyzer column, correlates with results obtained by gas chromatography. Using the breath acetone analyzer to quantify breath acetone concentrations of dieting subjects, we established a correlation between breath acetone concentration and rate of fat loss (slope 52.2 nmol/L per gram per day, intercept 15.3 nmol/L, n = 78, r = 0.81). We also discussed the possibility of using breath acetone in diabetes management.
authors.affiliation: Abbott Laboratories, Department 90J, Abbott Park, IL 60064.
authors.forename: S K
authors.initials: SK
authors.lastname: Kundu
authors.forename: J A
authors.initials: JA
authors.lastname: Bruzek
authors.forename: R
authors.initials: R
authors.lastname: Nair
authors.forename: A M
authors.initials: AM
authors.lastname: Judilla
mesh_terms: D000096:Acetone / Q000032:analysis*; D000273:Adipose Tissue / Q000378:metabolism*; D001944:Breath Tests; D002849:Chromatography, Gas; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008297:Male; D011786:Quality Control; D015431:Weight Loss
chemical_list: D000096:Acetone