Vigabatrin (gamma-vinyl-GABA): neuropathologic evaluation in five patients.
We performed neuropathologic examination of cerebral cortex specimens from 4 patients who underwent epilepsy surgery and the brain of 1 patient who died suddenly. All had severe epilepsy and had received gamma-vinyl-GABA (GVG, vigabatrin) for 3-5.5 years. Neither the surgically resected temporal lobe specimens nor the frontal and temporal lobes autopsy specimens showed abnormal white matter vacuolation.
Sivenius
J
J
Department of Neurology, University of Kuopio, Finland.
Paljärvi
L
L
Vapalahti
M
M
Nousiainen
U
U
Riekkinen
P J
PJ
D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects* / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D004827:Epilepsy / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008297:Male; D013702:Temporal Lobe / Q000187:drug effects / Q000473:pathology; D020888:Vigabatrin
D000614:Aminocaproates; D020888:Vigabatrin