title: Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule.
abstract: In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
authors.affiliation: Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Titti
authors.forename: M L
authors.initials: ML
authors.lastname: Koanga Mogtomo
authors.forename: A
authors.initials: A
authors.lastname: Borsetti
authors.forename: A
authors.initials: A
authors.lastname: Geraci
authors.forename: L
authors.initials: L
authors.lastname: Sernicola
authors.forename: G
authors.initials: G
authors.lastname: Panzini
authors.forename: G P
authors.initials: GP
authors.lastname: Turillazzi
authors.forename: S
authors.initials: S
authors.lastname: Baroncelli
authors.forename: A
authors.initials: A
authors.lastname: Giovannetti
authors.forename: R
authors.initials: R
authors.lastname: Zamarchi
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001483:Base Sequence; D002460:Cell Line; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D066298:In Vitro Techniques; D008252:Macaca fascicularis; D008297:Male; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D011247:Pregnancy; D011533:Proviruses / Q000235:genetics; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000302:isolation & purification / Q000494:pharmacology; D014765:Viral Vaccines / Q000302:isolation & purification / Q000494:pharmacology*; D014776:Virus Cultivation
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines