title: Vigabatrin (gamma-vinyl-GABA): neuropathologic evaluation in five patients.
abstract: We performed neuropathologic examination of cerebral cortex specimens from 4 patients who underwent epilepsy surgery and the brain of 1 patient who died suddenly. All had severe epilepsy and had received gamma-vinyl-GABA (GVG, vigabatrin) for 3-5.5 years. Neither the surgically resected temporal lobe specimens nor the frontal and temporal lobes autopsy specimens showed abnormal white matter vacuolation.
authors.affiliation: Department of Neurology, University of Kuopio, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Sivenius
authors.forename: L
authors.initials: L
authors.lastname: Paljärvi
authors.forename: M
authors.initials: M
authors.lastname: Vapalahti
authors.forename: U
authors.initials: U
authors.lastname: Nousiainen
authors.forename: P J
authors.initials: PJ
authors.lastname: Riekkinen
mesh_terms: D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects* / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D004827:Epilepsy / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008297:Male; D013702:Temporal Lobe / Q000187:drug effects / Q000473:pathology; D020888:Vigabatrin
chemical_list: D000614:Aminocaproates; D020888:Vigabatrin