title: Evaluation of a monoclonal antibody-based enzyme immunoassay for early detection of herpes simplex virus genital infection.
abstract: A monoclonal antibody-based enzyme immunoassay test for detection of herpes simplex virus (HSV) type-common antigen was evaluated in 40 women with vulvar lesion suspicious for genital HSV infection. The assay gave interpretable readings in 90% of the cases, with sensitivity and specificity of 100% and 92% respectively, a negative predictive value of 100%, and a positive predictive value of 75%. With a few limitations, the assay may be used for early diagnosis of genital HSV infection.
authors.affiliation: Department of Obstetrics and Gynecology, Lady Davis Carmel Hospital, Haifa, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Bornstein
authors.forename: E
authors.initials: E
authors.lastname: Ben-Porath
authors.forename: M
authors.initials: M
authors.lastname: Nizri
authors.forename: Y
authors.initials: Y
authors.lastname: Satinger
authors.forename: S
authors.initials: S
authors.lastname: Sperber
authors.forename: H
authors.initials: H
authors.lastname: Abramovici
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D005455:Fluorescent Antibody Technique; D006558:Herpes Genitalis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D018259:Herpesvirus 1, Human / Q000145:classification; D018258:Herpesvirus 2, Human / Q000145:classification; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D015995:Prevalence; D012680:Sensitivity and Specificity; D014773:Virology / Q000379:methods; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000911:Antibodies, Monoclonal