Comparison of MGH-1 and TuMark antibody detection in transitional cell carcinoma.
Two monoclonal antibodies, TuMark-BTA and MGH-1, were evaluated in patients with benign pathology, history of transitional cell carcinoma with no active disease and active transitional cell carcinoma. Both antibodies were accurate in predicting carcinoma in approximately two-thirds of patients. TuMark showed a 74% sensitivity and 50% specificity, while MGH-1 was more sensitive (86%) and less specific (38%). Positive predictive values for TuMark and MGH-1 were 79% and 78%, respectively.
Graham
S D
SD
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.
Watts
L
L
D000328:Adult; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000175:diagnosis*; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D001745:Urinary Bladder Diseases / Q000175:diagnosis*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm