Antigen identification in drug-induced bullous pemphigoid.
Immunobullous diseases usually develop spontaneously, but drug-induced bullous disease develops in a small subgroup of patients. We examined a patient in whom bullous pemphigoid developed after she received enalapril for treatment of hypertension. IgG antibody directed against a 230 kd antigen was identified. The eluted IgG autoantibody was shown to bind to the basement membrane zone on split skin. This study demonstrates that drug-induced bullous pemphigoid autoantibody in this patient was directed against the same antigen as the spontaneous bullous pemphigoid antigen.
Smith
E P
EP
Department of Internal Medicine, Veterans Affairs Medical Center, Salt Lake City, UT.
Taylor
T B
TB
Meyer
L J
LJ
Zone
J J
JJ
D000368:Aged; D000941:Antigens / Q000032:analysis*; D003622:Dapsone / Q000008:administration & dosage; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000276:immunology*
D000941:Antigens; D004656:Enalapril; D003622:Dapsone