Electroconvulsive shock-induced impairment of spatial learning is aggravated by nifedipine.
Chronic electroconvulsive treatment applied immediately after a training session or with a 15 min delay impairs spatial learning and memory in the Morris water maze paradigm, and this impairment is not counteracted, but rather aggravated by co-administration of a calcium channel blocker, nifedipine.
Popik
P
P
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Mamczarz
J
J
Vetulani
J
J
D000818:Animals; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D008568:Memory / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009543:Nifedipine