title: Effect of a new nootropic agent, CGS 5649B, on cognition, function, and behavior in dementia.
abstract: To determine the efficacy of CGS 5649B, the authors conducted a series of randomized, double-masked, single-subject studies using pairs of treatment periods, each pair including four weeks of active drug administration and four weeks of placebo administration. Thirty-two moderately demented patients completed three treatment pairs, receiving doses of 90, 200, or 600 mg of CGS 5649B during the active periods. Two patients met criteria for individual response in the behavioral measures. In the group analysis none of the differences achieved statistical significance. The authors conclude that CGS 5649B had a favorable impact on behavior for two of 32 patients.
authors.affiliation: Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: D W
authors.initials: DW
authors.lastname: Molloy
authors.forename: G H
authors.initials: GH
authors.lastname: Guyatt
authors.forename: T
authors.initials: T
authors.lastname: Standish
authors.forename: A
authors.initials: A
authors.lastname: Willan
authors.forename: W
authors.initials: W
authors.lastname: McIlroy
authors.forename: J
authors.initials: J
authors.lastname: D'Souza
authors.forename: G
authors.initials: G
authors.lastname: Brown
authors.forename: C
authors.initials: C
authors.lastname: Mondadori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001519:Behavior / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D003704:Dementia / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D011619:Psychotropic Drugs; D011725:Pyridines; C075505:6-(2-isopropylaminopropyl)-3-pyridinol