Angiotensin-converting enzyme activator from purified human neutrophils.
An endogenous ACE activator has been revealed. Neutrophil-enriched human leucocyte preparations released in isotonic media a relatively thermostable factor, capable of increasing the angiotensin-converting enzyme activity 1.6-2.0-fold. Activator would not pass through a 30 kDa cutoff membrane. Data on the presence of the activator in vivo were obtained in studies of protein-free serum fractions of patients with a hereditary CI-esterase inhibitor deficiency. It was suggested that the neutrophil-released ACE activator could have a role in the modulation of the inflammatory response.
Elisseeva YuE
Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences, Moscow.
Pavlikhina
L V
LV
Shavghulidze
T V
TV
Messina
E
E
Giacomello
A
A
Salerno
C
C
Perricone
R
R
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007668:Kidney / Q000201:enzymology; D008297:Male; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000737:chemistry*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D007703:Peptidyl-Dipeptidase A