Reduced haloperidol/haloperidol ratios after oral haloperidol and decanoate administration in schizophrenics.
1. Haloperidol and reduced haloperidol plasma concentrations were measured in thirteen stable schizophrenic patients that received both oral haloperidol and haloperidol decanoate. 2. Significant correlations between reduced haloperidol/haloperidol ratios from oral haloperidol and haloperidol decanoate occurred at week two and week 16, respectively. 3. The formation of RH was consistent during haloperidol decanoate treatment.
Chang
W H
WH
Laboratory of Biological Psychiatry, Taipei City Psychiatric Center.
Lin
S K
SK
Juang
D J
DJ
Chen
L C
LC
Yang
C H
CH
Hu
W H
WH
Chien
C P
CP
Lam
Y F
YF
Jann
M W
MW
D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012559:Schizophrenia / Q000188:drug therapy*
C040692:4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol; C033563:haloperidol decanoate; D006220:Haloperidol