Alpha-atrial natriuretic peptide attenuates ethanol withdrawal symptoms.
Mice were rendered tolerant to and dependent on ethanol with an ethanol-liquid diet for 14 days. Five hours after withdrawal from ethanol, withdrawal symptoms were analyzed by scoring handling-induced convulsions. Intracerebroventricular (i.c.v.) injection of alpha-atrial natriuretic peptide (alpha-ANP) attenuated, whereas that of an antiserum against alpha-ANP (anti-ANP) intensified the severity of handling-induced convulsions.
Kovács
G L
GL
Central Laboratory, Markusovszky Teaching Hospital, Szombathely, Hungary.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D000431:Ethanol; D009320:Atrial Natriuretic Factor