title: Intracoronary ultrasound assessment of directional coronary atherectomy: immediate and follow-up findings.
abstract: OBJECTIVE
  This study was conducted to assess the relations among intracoronary ultrasound, angiographic and histologic data obtained from patients with coronary artery disease successfully treated by directional coronary atherectomy. In addition, it was designed to elucidate whether some aspects of intravascular ultrasound or pathologic findings could predict a propensity to restenosis.
  
  
  BACKGROUND
  Intracoronary ultrasound is a useful technique in guiding and assessing atherectomy. However, there is little information about the characterization of the different types of coronary plaques and the changes observed in them after resection. Furthermore, the follow-up ultrasound appearance of previously treated lesions remains undepicted.
  
  
  METHODS
  Fifty-two patients (54 +/- 10 years old) were studied. All were successfully treated by atherectomy with the aid of intracoronary ultrasound guidance. Qualitative and quantitative ultrasound and angiographic variables were derived before and after resection. Quantitative histologic morphometric information was also obtained from the specimens. In 22 patients, a follow-up echoangiographic reevaluation was performed 6 +/- 4 months later.
  
  
  RESULTS
  Echogenic plaques had a higher collagen and calcium content, whereas echolucent plaques had an increased level of fibrin, nuclei and lipids. Ultrasound plaque reduction after atherectomy was greater in echolucent (76 +/- 21%) than in echogenic plaques (60 +/- 18%; p < 0.05). That reduction correlated with the weight of the resected material (r = 0.62; p < 0.01). At follow-up study, 13 of 22 patients had angiographic and ultrasound evidence of restenosis. Most recurrent lesions had a stenotic three-layer appearance. The incidence of restenosis of primary lesions treated with atherectomy was higher in echolucent (100%) than in echogenic (33%) plaques. Similarly, a higher proportion of nuclear content in the resected material was observed in patients who developed restenosis (2.1 +/- 0.7%) than in patients who had late success after atherectomy (1.2 +/- 0.6%).
  
  
  CONCLUSIONS
  Our findings suggest that echolucent plaques are easier to resect than are echogenic plaques but frequently develop restenosis. In contrast, the resection of echogenic plaques, although often incomplete, is associated with better long-term results.
authors.affiliation: Hospital Reina Sofía, University of Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Suárez de Lezo
authors.forename: M
authors.initials: M
authors.lastname: Romero
authors.forename: A
authors.initials: A
authors.lastname: Medina
authors.forename: M
authors.initials: M
authors.lastname: Pan
authors.forename: D
authors.initials: D
authors.lastname: Pavlovic
authors.forename: R
authors.initials: R
authors.lastname: Vaamonde
authors.forename: E
authors.initials: E
authors.lastname: Hernández
authors.forename: F
authors.initials: F
authors.lastname: Melián
authors.forename: F
authors.initials: F
authors.lastname: López Rubio
authors.forename: J
authors.initials: J
authors.lastname: Marrero
mesh_terms: D017225:Atherectomy, Coronary; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors; D014463:Ultrasonography