Role of acid tolerance response genes in Salmonella typhimurium virulence.
The atp and fur genes are involved in the acid tolerance response of Salmonella typhimurium. An atp::Tn10 mutant was avirulent in the mouse typhoid model when assayed by oral and intraperitoneal routes. However, a fur mutant was completely virulent by the intraperitoneal route. No relevant differences in intracellular survival or invasion rates were observed for the two mutants in macrophages and epithelial cells. These data indicate that separate acid tolerance response genes may have different roles in S. typhimurium virulence.
Garcia-del Portillo
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Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
Foster
J W
JW
Finlay
B B
BB
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D004285:Dogs; D005798:Genes, Bacterial; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008807:Mice, Inbred BALB C; D016254:Mutagenesis, Insertional; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D014435:Typhoid Fever / Q000382:microbiology
D001426:Bacterial Proteins; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D006180:Proton-Translocating ATPases