title: The effect of short-term celiprolol therapy on platelet function in essential hypertension.
abstract: The reduction of increased platelet aggregation in essential hypertension is one of the aims of modern antihypertensive therapy. Twenty-one hospitalized patients with non-treated essential hypertension were examined. The platelet function measurements were made before the therapy and after 1 week of celiprolol administration (300 mg/day). Fifteen essentially hypertensive patients were investigated before and after 1 week of placebo administration. Plasma beta-thromboglobulin was assayed, and the whole blood platelet aggregation (initial and total-induced by adrenaline and ADP) was measured. A significant decrease in adrenaline-induced (from 19 to 13%, p < 0.02) and ADP-induced aggregation (from 15 to 13%, p < 0.05) was observed after celiprolol administration. This reduction of adrenaline-induced platelet aggregation may be explained by the stimulation effect of celiprolol on platelet beta 2-receptors. Thus, some inhibitory effect of celiprolol on platelet aggregation is one of the further advantages of this drug in the therapy of essential hypertension.
authors.affiliation: First Department of Internal Medicine, Faculty Hospital, Comenius University, Bratislava, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Okrucká
authors.forename: J
authors.initials: J
authors.lastname: Pechán
authors.forename: I
authors.initials: I
authors.lastname: Balazovjech
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D017272:Celiprolol / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D001620:beta-Thromboglobulin / Q000378:metabolism
chemical_list: D010975:Platelet Aggregation Inhibitors; D001620:beta-Thromboglobulin; D017272:Celiprolol