Identification of putative internalization signals in prion proteins.
Prion proteins were found to contain regions in their cytoplasmic domains that have significant structural homologies to molecular trafficking signals for internalization of membrane proteins. These regions may facilitate the endocytosis of prion proteins, which appears to be a first step in their conversion to the abnormal, amyloidogenic form.
Kazim
A L
AL
Department of Molecular Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263.
D000595:Amino Acid Sequence; D000818:Animals; D004705:Endocytosis; D006801:Humans; D008969:Molecular Sequence Data; D011328:Prions / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D011328:Prions; D021382:Protein Sorting Signals