Prevention of postoperative abdominal adhesions by tissue precoating with polymer solutions.
Polyvinylpyrrolidone (PVP) and carboxymethylcellulose (CMC) solutions were evaluated in a rat cecal abrasion model to test the effect of these high-molecular-weight hydrophilic polymer solutions on postoperative adhesion formation when used as tissue precoating solutions. Eleven groups of 5-20 animals each were studied including 25 control animals treated with Ringer's lactate (RL) solution. Animals were reoperated at 2 weeks and adhesions were scored according to a 0-4 grading scale. Tissue coating following cecal abrasion failed to inhibit adhesion formation. However, tissue coating with polymer solutions prior to cecal abrasion significantly reduced the formation of post-operative adhesions. Solutions of 1.5% CMC and 5% of a unique gamma-polymerized PVP in RL exhibited the greatest tissue-protective behavior compared to RL controls (P < 0.002). Both CMC and gamma-PVP solutions warrant further investigation as tissue precoatings to inhibit surgical adhesions.
Yaacobi
Y
Y
Biomedical Engineering Center, University of Florida, Gainesville 32611.
Israel
A A
AA
Goldberg
E P
EP
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D002432:Cecum / Q000601:surgery; D005260:Female; D011183:Postoperative Complications / Q000517:prevention & control*; D011205:Povidone / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012996:Solutions; D000267:Tissue Adhesions / Q000517:prevention & control*
D012996:Solutions; D011205:Povidone; D002266:Carboxymethylcellulose Sodium