Subzonal multiple sperm injection in the treatment of previous failed human in vitro fertilization.
OBJECTIVE
To assess the value of subzonal sperm injection in previous failed spontaneous in vitro fertilization (IVF).


METHODS
Prospective study on patients with at least one cycle of previous failed spontaneous IVF.


METHODS
Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.


METHODS
Thirty-nine patients with prolonged infertility with at least one previous cycle of failure of spontaneous fertilization of any oocyte.


RESULTS
Seventy-eight of 276 oocytes successfully injected with three to four sperms were fertilized. Fertilized rate was 28.2%. Polyspermy was observed in 6 (8%) of the fertilized oocytes. Sixty-six (92%) of the 72 with monospermic fertilization cleaved normally and were replaced in the uterine cavity. Pregnancy occurred in 6 (23%) of the women who had embryos replaced.


CONCLUSIONS
Multiple sperm injection into the oocyte subzonal space should be considered for the treatment of patients with previous failed spontaneous IVF.
Imoedemhe
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DA
Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
Sigue
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AB
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D009865:Oocytes; D011247:Pregnancy; D011256:Pregnancy Outcome; D013094:Spermatozoa; D017211:Treatment Failure