Altered behaviour in adult mice orally exposed to tri- and tetrachloroethylene as neonates.
Male NMRI mice were orally exposed to trichloroethylene (TRI, 50 and 290 mg/kg per day) and tetrachloroethylene (PER, 5 and 320 mg/kg per day) between days 10 and 16 postnatally. Spontaneous activity, observed as locomotion, rearing and total activity, was measured over three 20-min periods at an age of 17 and 60 days. Compared to controls, mice at 17 days of age were unaffected, while at 60 days of age mice exposed to PER showed changes in all three spontaneous motor activity variables, while TRI-exposed mice only were affected in rearing. This indicates a neonatal susceptibility of brain maturation to these chlorinated organic solvents in achieving long-lasting changes in adult behaviour.
Fredriksson
A
A
Department of Toxicology, Uppsala University, Sweden.
Danielsson
B R
BR
Eriksson
P
P
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D013750:Tetrachloroethylene / Q000633:toxicity*; D014241:Trichloroethylene / Q000633:toxicity*
D014241:Trichloroethylene; D013750:Tetrachloroethylene