Immunization of Macaca fascicularis with inactivated SIV preparations: challenge with human- or monkey-derived SIV and the effects of a longer immunization schedule.
In cynomolgus monkeys, we compared two human-derived SIVmac251 whole virus vaccines, a long vs short immunization schedule, and two different challenge viruses. Both vaccines induced protection after challenge with human-derived SIVmac251/32H. There was no difference between the two schedules of immunization. Seven monkeys, five of which were protected following the first challenge, were reboosted and rechallenged with monkey-derived SIVmac251, but no protection was observed. The titers of anti-human cell or -SIV neutralizing antibodies were not related to protection.
Titti
F
F
Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
Koanga Mogtomo
M L
ML
Borsetti
A
A
Geraci
A
A
Sernicola
L
L
Panzini
G
G
Turillazzi
G P
GP
Baroncelli
S
S
Giovannetti
A
A
Zamarchi
R
R
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001483:Base Sequence; D002460:Cell Line; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D066298:In Vitro Techniques; D008252:Macaca fascicularis; D008297:Male; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D011247:Pregnancy; D011533:Proviruses / Q000235:genetics; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000302:isolation & purification / Q000494:pharmacology; D014765:Viral Vaccines / Q000302:isolation & purification / Q000494:pharmacology*; D014776:Virus Cultivation
D000914:Antibodies, Viral; D004279:DNA, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines