title: Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period.
abstract: In 10 moderately obese women, 24-h energy expenditure (24EE) was measured in a respiration chamber under four conditions: 1) before weight loss (body weight = 77.9 kg), 2) during weight loss (63.9 kg), 3) after realimentation (62.5 kg), and 4) 6-15 mo after the study diet with ad libitum diet (67.7 kg). The 14 +/- 8 kg (mean +/- SD) weight loss produced a decrease in 24EE of 1498 +/- 1138 kJ/d (P < 0.001), ie, a decrease of weight of 107 kJ.kg body wt-1.d-1. The subsequent 24EE (conditions 3 and 4) remained lower than the value before weight loss. A significant correlation was found between changes before and after weight regain in basal respiratory quotient (RQ) and the spontaneous rate of body-weight gain after cessation of the period of low energy intake (r = 0.89, P < 0.01); this suggests that the value of the postabsorptive RQ may be a predictor of relapse of weight gain. After discontinuation of the low energy diet, an elevated postabsorptive RQ shows that the endogenous lipid oxidation is low, a condition favoring weight gain.
authors.affiliation: Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Froidevaux
authors.forename: Y
authors.initials: Y
authors.lastname: Schutz
authors.forename: L
authors.initials: L
authors.lastname: Christin
authors.forename: E
authors.initials: E
authors.lastname: Jéquier
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002395:Catecholamines / Q000652:urine; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004435:Eating / Q000502:physiology*; D004734:Energy Metabolism; D005260:Female; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism*; D010084:Oxidation-Reduction; D005082:Physical Exertion / Q000502:physiology; D011446:Prospective Studies; D013963:Thyroid Hormones / Q000097:blood; D015430:Weight Gain / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D004040:Dietary Carbohydrates; D007328:Insulin; D013963:Thyroid Hormones