[Modification of adrenergic regulation of heart function under effect of radio-ecological factors within 10-kilometer zone of the accident at Chernobyl nuclear plant].
Rats kept within the ten-kilometer zone of Chernobyl disaster over a period of 30 days exhibited a decreased heart function response to beta-adrenoreceptor stimulus, reduced density of the receptor structures in cardiomyocytes and their affinity to specific agonists. The number of beta-adrenoreceptors in myocardium cells was restored in 6 months, but their affinity and heart function response to the effect of beta-adrenoagonists remained decreased. No significant changes were observed in regulation influenced indirectly via alpha-adrenoreceptors.
Lobanok
L M
LM
Kirienkov
A E
AE
Gerasimovich
N V
NV
D000062:Accidents, Occupational; D000818:Animals; D004781:Environmental Exposure; D006321:Heart / Q000187:drug effects / Q000528:radiation effects*; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects / Q000528:radiation effects*; D009688:Nuclear Reactors; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000528:radiation effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol