Cerebral cortex injury: effect of blockers of re-uptake of catecholamines.
In rats, surgical injury of the neocortex enhances the level of procholecystokinin-mRNA in the ipsilateral cortex. This increase in procholecystokinin gene expression was significantly reduced by the blockers of catecholamine re-uptake nomifensine (4 mg/kg), cocaine (5 mg/kg) and (+)-oxaprotiline (1.5 mg/kg) given i.m. 30 min before the injury. The ganglionic blocking agent hexamethonium (3 mg/kg) prevented this effect of (+)-oxaprotiline and nomifensine. Also the alpha 1-adrenoceptor antagonists corynanthine (2 mg/kg) and prazosin (2 mg/kg) blocked this effect of (+/-)-oxaprotiline (1.5 mg/kg). It is concluded that catecholamines acting on alpha 1-adrenoceptors can reduce the increase in procholecystokinin-mRNA caused by cortex injury. The catecholamines may be released from the sympathetic nervous system.
Mondeh
J D
JD
Department of Pharmacology, University of Freiburg, Germany.
Olenik
C
C
Götz
E
E
Uhl
A
A
Meyer
D K
DK
D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D002540:Cerebral Cortex / Q000293:injuries*; D002766:Cholecystokinin / Q000235:genetics; D008297:Male; D008376:Maprotiline / Q000031:analogs & derivatives / Q000494:pharmacology; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology*; D009627:Nomifensine / Q000494:pharmacology; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D002395:Catecholamines; D014179:Neurotransmitter Uptake Inhibitors; D011498:Protein Precursors; D012333:RNA, Messenger; D018340:Receptors, Adrenergic, alpha-1; D009627:Nomifensine; D008376:Maprotiline; C027299:hydroxymaprotilin; C060249:procholecystokinin; D002766:Cholecystokinin