Pathogenesis of colorectal cancer.
This article takes the reader from colorectal lumen to the intracellular environment in an effort to explain the processes of tumorigenesis in colorectal cancer. The molecular changes seen in colorectal cancer development also are discussed, along with the potential for genetic manipulation and diagnostic molecular techniques. An era of major advances in understanding the pathogenesis of colorectal cancer has begun.
Milsom
J W
JW
Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio.
D000236:Adenoma / Q000209:etiology; D002277:Carcinoma / Q000209:etiology; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D009154:Mutation