title: Selective impairment of T lymphocyte activation through the T cell receptor/CD3 complex after cytomegalovirus infection.
abstract: Cytomegalovirus (CMV) infection is reported to cause transient immunosuppression in man. In this study we have analysed the effect of CMV on T lymphocyte function in 29 children diagnosed for acute CMV infection. Peripheral blood mononuclear cells (PBMC) obtained from the patients showed a significant specific impairment in their proliferative response to enterotoxins A and C1, to concanavalin A and to the anti-CD3 MoAb OKT3. The impaired responses were corrected with exogenous IL-2. In contrast, stimulation using phytohaemagglutinin, as well as activation signals delivered through the surface molecules CD26 or CD28, elicited normal proliferative responses in CMV PBMC. The results indicate that the T cell anergy associated with CMV infection is restricted to the T cell receptor/CD3 activation pathway.
authors.affiliation: Department of Immunology, Hospital 12 de Octubre Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Timón
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Contreras
authors.forename: J T
authors.initials: JT
authors.lastname: Ramos-Amador
authors.forename: A
authors.initials: A
authors.lastname: Pacheco
authors.forename: J R
authors.initials: JR
authors.lastname: Regueiro
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation; D008297:Male; D010641:Phenotype; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D017260:Receptor-CD3 Complex, Antigen, T-Cell