Borna disease virus in mice: host-specific differences in disease expression.
We developed a mouse model of Borna disease to facilitate immunopathogenesis research by adaptation of Borna disease virus to mice through serial passage in mouse brain tissue. Borna disease virus replication, antibody production, inflammation, and Borna disease expression in several different strains of mice were examined.
Rubin
S A
SA
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Waltrip
R W
RW
Bautista
J R
JR
Carbone
K M
KM
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001890:Borna Disease / Q000382:microbiology* / Q000473:pathology; D001891:Borna disease virus / Q000254:growth & development; D001921:Brain / Q000382:microbiology; D004195:Disease Models, Animal; D004660:Encephalitis / Q000473:pathology; D014644:Genetic Variation; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity; D012692:Serial Passage
D000914:Antibodies, Viral