title: Segmental ischemic colitis associated with nonsteroidal antiinflammatory drugs.
abstract: We have seen two cases of a segmental ischemic colitis develop during nonsteroidal antiinflammatory drug (NSAID) treatment. No other possible etiologic factors were shown. The short-term clinical course and the follow-up were uneventful. NSAIDs have been reported to cause different lesions in the large bowel, either by worsening preexisting colonic diseases or by inducing a primary pathology. We suggest that ischemia should be considered a possible mechanism of NSAID-associated colitis. Such ischemic colitis, not triggered by severe cardiovascular disease or operation, may be related to NSAIDs more often than currently recognized.
authors.affiliation: Cattedra di Gastroenterologia, Università di Napoli, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Carratù
authors.forename: P
authors.initials: P
authors.lastname: Parisi
authors.forename: A
authors.initials: A
authors.lastname: Agozzino
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001706:Biopsy; D017091:Colitis, Ischemic / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal