Biosynthesis in vitro of 2-(3-amino-3-carboxypropyl)-isoxazolin-5-one, the neurotoxic amino acid in Lathyrus odoratus.
2-(3-Amino-3-carboxypropyl)-isoxazolin-5-one (ACI), a neurotoxic amino acid from Lathyrus odoratus, was confirmed to be derived enzymatically from S-adenosyl-L-methionine (SAM) and isoxazolin-5-one. Some properties of an enzyme in the biosynthesis of ACI are described.
Ikegami
F
F
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Sakai
R
R
Ishikawa
T
T
Kuo
Y H
YH
Lambein
F
F
Murakoshi
I
I
D000613:Aminobutyrates / Q000378:metabolism*; D007887:Fabaceae / Q000378:metabolism*; D007555:Isoxazoles / Q000378:metabolism*; D010946:Plants, Medicinal; D012436:S-Adenosylmethionine / Q000378:metabolism*
D000613:Aminobutyrates; D007555:Isoxazoles; C013076:isoxazolin-5-one; C083644:2-(3-amino-3-carboxypropyl)isoxazolin-5-one; D012436:S-Adenosylmethionine