Oxyradical-mediated chromosome damage in patients with familial Mediterranean fever.
Increased chromosome breakage is observed in patients with familial mediterranean fever (FMF). Their plasma contains clastogenic material inducing chromosome damage in cells from healthy persons. It is proposed that increased oxyradical generation by activated polymorphonuclear cells in blood and serosal fluids of these patients leads to the formation of a clastogenic factor (CF), as it is observed in other chronic inflammatory diseases. Also similar to these diseases, the clastogenic effects are prevented by superoxide dismutase and partially by inhibitors of arachidonic acid metabolism.
Emerit
I
I
Department of Genetics, Centre de Recherches Bio-médicales des Cordeliers CNRS & University of Paris, France.
Arutyunyan
R
R
Sarkisian
T
T
Mejlumian
H
H
Torosian
E
E
Panossian
A G
AG
D000293:Adolescent; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D004249:DNA Damage; D010505:Familial Mediterranean Fever / Q000097:blood / Q000235:genetics*; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D009153:Mutagens / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012854:Sister Chromatid Exchange; D013482:Superoxide Dismutase / Q000494:pharmacology
D005609:Free Radicals; D009153:Mutagens; D017382:Reactive Oxygen Species; D016718:Arachidonic Acid; D013482:Superoxide Dismutase