SCE frequencies induced by ethanol, tequila and brandy in mouse bone marrow cells in vivo.
The genotoxicity of ethanol, tequila and brandy was evaluated by scoring the frequency of sister chromatid exchanges (SCE) and determining the values of the average generation time (AGT). We studied four dosages of each substance i.p. inoculated into mice. The cytogenetic analysis was performed in bone marrow cells. The results showed that all three substances were weak genotoxicants. Tequila showed the strongest response followed by brandy and ethanol. None of them modified the cell proliferation kinetics as demonstrated by the AGT results.
Piña Calva
A
A
Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Mexico City, Mexico.
Madrigal-Bujaidar
E
E
D000434:Alcoholic Beverages / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000502:physiology; D001854:Bone Marrow Cells; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000431:Ethanol