Agonist regulation of gene expression of adrenergic receptors and G proteins.
Study of transmembrane signaling via G proteins has focused to a large extent upon investigations of individual G protein-linked receptor-effector systems. Agonist-induced desensitization and down-regulation of beta-adrenergic receptors, for example, have been studied extensively and adopted as a general model for G protein-linked receptor regulation. This review focuses not only on agonist regulation of adrenergic receptor gene expression, but also on how agonists regulate opposing adrenergic receptor-mediated pathways. This important feature of G protein-mediated pathways, i.e., cross-regulation and integration of information among several pathways, will be discussed in the context of what has been learned in the adrenergic receptor-coupled pathways.
Hadcock
J R
JR
Department of Molecular Pharmacology, School of Medicine, SUNY/Stony Brook 11794-8651.
Malbon
C C
CC
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D011941:Receptors, Adrenergic / Q000502:physiology*; D013268:Stimulation, Chemical; D010738:Type C Phospholipases / Q000378:metabolism
D000067956:Adenylyl Cyclase Inhibitors; D011941:Receptors, Adrenergic; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases