Contra: CD8+ T-cell-mediated suppression without 'suppressor' T cells?
This commentary argues that conventional antiviral cytotoxic T cells act suppressively by eliminating antigen-presenting cells, sometimes including lymphocytes, T or B cells expressing relevant antigens of exogenous or endogenous, most commonly of viral origin. They thereby limit expression of antigens, and by eliminating the antigen-expressing cells stop immune responses. However, to argue that induced T cells (or antibodies) function to eliminate or neutralize antigen is the shortest summary of immunology and neither new nor heretic.
Zinkernagel
R M
RM
Institute of Experimental Immunology, University of Zurich, Switzerland.
Hengartner
H
H
D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis* / Q000276:immunology; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D016827:CD8 Antigens