Unexpected pulmonary clumping of In-111 leukocytes attributable to indium oxine reagent.
Five cases of artifactual In-111 leukocyte pulmonary activity were noted at three local hospitals in a 4-day period. Based on the differences in the preparation of the final indium leukocyte product, the problem could be attributed to the indium oxine reagent in a specific lot. This artifact of multiple small foci of marked increased activity in the lungs (clumping pattern), attributable to the In-111 oxine reagent, has not been described previously.
Bohdiewicz
P J
PJ
Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan 48073-6769.
Fink-Bennett
D
D
Nagle
C
C
Abghari
R
R
Gutkowski
R
R
Dworkin
H J
HJ
D000368:Aged; D016477:Artifacts; D005260:Female; D006801:Humans; D007202:Indicators and Reagents / Q000009:adverse effects; D007205:Indium Radioisotopes / Q000493:pharmacokinetics*; D007962:Leukocytes; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000009:adverse effects*; D015125:Oxyquinoline / Q000009:adverse effects / Q000031:analogs & derivatives*
D007202:Indicators and Reagents; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline