[Anti-pyretic activity of aqua-(diacetoxybenoate)-copper complexes].
The antipyretic activity of binuclear (diacetoxybenzoato)-copper(II) aquacomplexes [Cu2(2,Y-DAB)4(H2O)2] (Y = 4 and 5) as well as cupric acetylsalicylate [Cu2(AcSal)4] was assayed in a rabbit model of endotoxin-induced fever. The complexes and uncomplexed carboxylic acids (administered i.p. in a dose of 20 mg/kg) exhibited even a subnormothermic course in lowering of febrile animals' body temperature in the order: 2,5-diacetoxybenzoic acid (-0.09 degree C) < 2,4-diacetoxybenzoic acid (-0.35 degree C) < Cu(AcSal)2(-0.39 degree C) approximately equal to acetylsalicylic acid (-0.40 degree C) < Cu(2,4-DAB)2.H2O (-0.61 degree C) < Cu(2.5-DAB)2.H2O (-0.97 degree C). On the other hand, the mean value of untreated fevered animals was +0.67 degree C.
Sokolík
J
J
Katedra chemickej teórie lieciv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Tumová
I
I
Lucanská
B
B
Blahová
M
M
Svec
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D003300:Copper / Q000627:therapeutic use*; D004731:Endotoxins; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D062385:Hydroxybenzoates / Q000627:therapeutic use*; D051379:Mice; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004731:Endotoxins; D062385:Hydroxybenzoates; D009942:Organometallic Compounds; D003300:Copper