Factors in the cerebrospinal fluid of multiple sclerosis patients interfering with voltage-dependent sodium channels.
The effect of cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) on voltage-dependent Na+ channels in human myoballs was studied. The transient Na+ currents, elicited by whole-cell depolarization from -85 to -20 mV, were decreased to 75-25% the control value in the presence of CSF from all 7 MS patients investigated. The effect was complete in about 5 s and was fully reversible on admission of standard external fluid. Such decrease was not or only to a minor extent observed with 10 out of 11 control CSFs from patients without inflammatory neurological disease. The origin of the factors interfering with the Na+ channels is unknown. It is suggested that, in addition to demyelination, impaired Na+ channel function might cause the symptoms in MS.
Brinkmeier
H
H
Wollinsky
K H
KH
Seewald
M J
MJ
Hülser
P J
PJ
Mehrkens
H H
HH
Kornhuber
H H
HH
Rüdel
R
R
D002478:Cells, Cultured; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid*; D009132:Muscles / Q000502:physiology*; D012016:Reference Values; D015222:Sodium Channels / Q000502:physiology*; D013997:Time Factors
D015222:Sodium Channels