Aspirin induces non-enzymatic formation of platelet-activating factor from lyso platelet-activating factor.
Substantial amounts of platelet-activating factor (PAF) were formed when lysoPAF was mixed with aspirin (e.g. 0.04% of added lysoPAF (200 nmol) was converted to PAF when mixed with aspirin (2 mumol) for 1 h). Non-enzymatic formation of PAF from aspirin and lysoPAF also occurs in the aqueous solution or in organic solvents in time-dependent and dose-dependent manners. Possible meanings of the non-enzymatic formation of PAF are discussed.
Mabuchi-Itoh
K
K
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Sugiura
T
T
Cheng
N N
NN
Waku
K
K
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001681:Biological Assay; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D007700:Kinetics; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D001241:Aspirin