title: Estimation of anterior infarct size with body surface QRST integral maps in the presence of abnormal ventricular activation sequence in dogs.
abstract: The possibility of estimating infarct size with body surface QRST integral (IQRST) maps was investigated in dogs. IQRST maps were constructed from 87-lead body surface ECGs, which were recorded 1 week after the production of anterior myocardial infarction during artificial pacing that simulated normal conduction, left bundle branch block, and Wolff-Parkinson-White syndrome in 11 dogs. Small differences were observed between the IQRST maps of the normal conduction and left bundle branch block models (r = 0.93, root mean square difference = 8.71 mVmsec) and between the normal conduction and Wolff-Parkinson-White models (r = 0.96, root mean square difference = 6.03 mVmsec). Summation of the QRST integral values over the body surface leads (QRST index) inversely correlated with infarct size in all three conductions models: r = 0.91 (p < 0.001) in the normal conduction model; r = -0.81 (p < 0.001) in the left bundle branch block model; and r = -0.86 (p < 0.001) in the Wolff-Parkinson-White model. These results show that IQRST maps permit noninvasive estimation of infarct size, even in the presence of abnormal activation sequences.
authors.affiliation: First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ichihara
authors.forename: M
authors.initials: M
authors.lastname: Hirai
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tomita
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Tsuda
authors.forename: M
authors.initials: M
authors.lastname: Nagasaka
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000818:Animals; D002037:Bundle-Branch Block / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D004562:Electrocardiography; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D012680:Sensitivity and Specificity; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications / Q000503:physiopathology*