title: Comparison of Gd-EOB-DTPA and Gd-DTPA for contrast-enhanced MR imaging of liver tumors.
abstract: A new hepatobiliary contrast agent for magnetic resonance (MR) imaging, gadolinium-ethoxybenzyl (EOB)-diethylemetriaminepentaacetic acid (DTPA), was compared with Gd-DTPA to define the potential for improving tumor-liver contrast in a rodent liver adenocarcinoma model. With a T1-weighted spin-echo sequence, the contrast-to-noise ratio (C/N) for tumor before contrast agent administration was 5 (arbitrary units), the tumor appearing slightly hypo-intense with respect to liver parenchyma. After Gd-DTPA injection (0.1 mmol/kg), tumor enhanced more strongly than liver, resulting in an equalization of tumor and liver signal intensities and a decline in C/N to zero at 3 minutes after injection. After Gd-EOB-DTPA injection (0.1 mmol/kg), liver enhanced more strongly than tumor. Five minutes after injection, C/N increased from 5 to 25 and remained above 17 for 50 minutes. The data indicate that Gd-EOB-DTPA yields higher and more prolonged tumor-liver contrast than Gd-DTPA on T1-weighted spin-echo images. The high liver-tumor contrast after Gd-EOB-DTPA administration should prove clinically advantageous for MR imaging detection of focal hepatic masses.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143-0628.
authors.forename: O
authors.initials: O
authors.lastname: Clemént
authors.forename: A
authors.initials: A
authors.lastname: Mühler
authors.forename: V S
authors.initials: VS
authors.lastname: Vexler
authors.forename: R
authors.initials: R
authors.lastname: Kuwatsuru
authors.forename: Y
authors.initials: Y
authors.lastname: Berthezène
authors.forename: W
authors.initials: W
authors.lastname: Rosenau
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
mesh_terms: D000818:Animals; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D007089:Image Enhancement / Q000379:methods; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA