The beta-endorphin response to prenatal stress during postnatal development in the rat.
We examined the hypothalamic beta-endorphin (B-END) levels in offspring (postnatal day 10) from stressed female rats in different period of gestation: group 1, restraint stress from day 2 to 6; group 2, from day 7 to 11 and group 3, from day 2 to 16. The hypothalamic levels of B-END in the offspring from group 1 were significantly (P < 0.001) higher to that obtained in the control. Similar results were obtained in the group 2. However, in rat pups from female stressed during 15 days of gestation hypothalamic levels of B-END were similar to control group.
Sánchez
M D
MD
Department of Physiology and Pharmacology, Faculty of Medicine, University of Murcia, Spain.
Milanés
M V
MV
Fuente
T
T
Laorden
M L
ML
D000818:Animals; D005260:Female; D005865:Gestational Age; D007031:Hypothalamus / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000378:metabolism*; D001615:beta-Endorphin / Q000378:metabolism*
D001615:beta-Endorphin