title: Methotrexate and reproduction in men: case report and recommendations.
abstract: Methotrexate has been used in the treatment of recalcitrant psoriasis for more than 35 years. We examined the significance of impaired spermatogenesis in a young man undergoing methotrexate treatment for severe psoriasis with associated arthritis. A medical geneticist was consulted and a review of the literature was performed. Genetic abnormalities that could lead to mutagenesis include chromosomal abnormalities and single-gene mutations. These aspects are considered and recommendations are made for counseling men undergoing methotrexate therapy so that risks and options can be considered.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas.
authors.forename: L F
authors.initials: LF
authors.lastname: Morris
authors.forename: M J
authors.initials: MJ
authors.lastname: Harrod
authors.forename: M A
authors.initials: MA
authors.lastname: Menter
authors.forename: A K
authors.initials: AK
authors.lastname: Silverman
mesh_terms: D000328:Adult; D001168:Arthritis / Q000150:complications; D002869:Chromosome Aberrations / Q000139:chemically induced; D025063:Chromosome Disorders; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D009154:Mutation; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D013091:Spermatogenesis / Q000187:drug effects*
chemical_list: D008727:Methotrexate