T-cell-depleted maternal bone marrow transplantation for siblings with X-linked severe combined immunodeficiency.
Prenatal diagnosis of X-linked severe combined immunodeficiency in a male fetus made possible elective neonatal bone marrow transplantation before onset of symptoms. Bone marrow transplantation was performed by using T-cell-depleted maternal marrow that had been cryopreserved 2 years earlier, at the time that his older affected brother underwent transplantation. The second patient had less morbidity and more rapid reconstitution of his immune function.
Himelstein
B P
BP
Division of Oncology, Children's Hospital of Philadelphia, PA 19104.
Puck
J
J
August
C
C
Pierson
G
G
Bunin
N
N
D000483:Alleles; D000649:Amniocentesis; D016026:Bone Marrow Transplantation / Q000379:methods* / Q000473:pathology; D015925:Cryopreservation; D005260:Female; D005315:Fetal Diseases / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D016511:Severe Combined Immunodeficiency / Q000235:genetics* / Q000601:surgery*; D013601:T-Lymphocytes / Q000473:pathology; D014021:Tissue Preservation / Q000379:methods; D014960:X Chromosome