[Influenza epidemic in a nursing home caused by a virus not included in the vaccine].
In the autumn of 1992 two-thirds of the population of a nursing home in Amsterdam was vaccinated against influenza. However, in March 1993 an outbreak of an influenza like illness occurred with a morbidity rate of 49% and a mortality rate of 10%. There was sufficient serological evidence to show that the vaccine as such had induced adequate immunity. As the causative agent an influenza A/H3N2 virus was identified. The failing activity of the vaccine in this instance was apparently caused by the absence of sufficient antigen similarity between the A/H3N2 vaccine component and the epidemic virus ('vaccine mismatch').
Beyer
W E
WE
Nationaal Influenza Centrum van de WHO, Erasmus Universiteit, afd. Virologie, Rotterdam.
Bakker
G
G
van Beek
R
R
Masurel
N
N
D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000302:isolation & purification; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009735:Nursing Homes
D000914:Antibodies, Viral; D007252:Influenza Vaccines