Bullous eruption with circulating pemphigus-like antibodies following interferon-alpha therapy.
Two patients with classic Kaposi sarcoma developed bullous lesions and pemphigus-like 'anti-intercellular-substance' antibodies when treated with interferon-alpha (IFN-alpha). In one of them direct immunofluorescence was consistent with pemphigus/pemphigoid features. The immunoprecipitation test showed no specific bands. The mechanism by which IFN-alpha may induce the production of anti-intercellular-substance antibodies is discussed.
Parodi
A
A
Department of Dermatology, University of Genoa, Italy.
Semino
M
M
Gallo
R
R
Rebora
A
A
D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D010392:Pemphigus / Q000209:etiology* / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000628:therapy; D012867:Skin / Q000276:immunology; D012878:Skin Neoplasms / Q000628:therapy
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G; D016898:Interferon-alpha