The role of the renin-angiotensin system in insulin sensitivity in normotensive subjects.
Nonobese patients with essential hypertension have been reported to be insulin resistant. Because blockade of the renin-angiotensin system has been demonstrated to improve insulin sensitivity in hypertensive patients, the authors evaluated the effects of angiotensin-II administration and of angiotensin-converting enzyme inhibition with enalapril on insulin-mediated glucose uptake in normotensive men. The results showed no change in insulin sensitivity with either 0.3 ng/kg/min or 1 ng/kg/min angiotensin-II administration or with enalapril therapy. The authors conclude that neither physiologic amounts of angiotensin-II nor converting enzyme inhibition alter insulin sensitivity in normotensive men.
Townsend
R R
RR
Department of Medicine, University of Texas Medical Branch, Galveston 77555.
DiPette
D J
DJ
Lieux
T R
TR
Wolfe
R R
RR
D000328:Adult; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology; D002395:Catecholamines / Q000097:blood; D004351:Drug Resistance; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology; D005947:Glucose / Q000493:pharmacokinetics; D015309:Glucose Clamp Technique; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*
D002395:Catecholamines; D007328:Insulin; D000804:Angiotensin II; D004656:Enalapril; D005947:Glucose; D011188:Potassium