title: Melanoma associated with ring chromosome 7.
abstract: We report the case of a 17-year-old girl with a constitutional chromosome anomaly (ring chromosome 7), associated with multiple pigmented skin lesions, who developed malignant melanoma. Eight other cases of ring chromosome 7 are described in the literature; all present vascular or pigmented skin lesions, but our patient was the first to develop a malignant tumor. Genetic studies in malignant melanoma are discussed, as well as the possible link between a constitutional anomaly of chromosome 7 and the occurrence of malignant melanoma. This association is possibly not fortuitous, particularly since most ring chromosome 7 patients reported to date have pigmented skin lesions.
authors.affiliation: Department of Dermatology, University Hospital, Geneva, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Vollenweider Roten
authors.forename: C D
authors.initials: CD
authors.lastname: Delozier-Blanchet
authors.forename: I
authors.initials: I
authors.lastname: Masouyé
authors.forename: J H
authors.initials: JH
authors.lastname: Saurat
mesh_terms: D000293:Adolescent; D002897:Chromosomes, Human, Pair 7; D004416:Dysplastic Nevus Syndrome / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D009508:Nevus, Pigmented / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D012303:Ring Chromosomes; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*