High-performance liquid chromatographic method for the determination of dimethindene in urine.
An automated high-performance liquid chromatographic assay, using on-line solid-phase extraction, is described for the determination of dimethindene in urine. The solid-phase extraction of the sample (1000 microliters) and the elution of the drug on to the analytical column are performed automatically and concomitantly. The limit of quantification is 5 pmol/ml.
Chollet
D
D
Department of Toxicology and Pharmacokinetics, Zyma SA, CH-1260, Nyon, Switzerland.
Künstner
P
P
Wermeille
M
M
D001331:Automation; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004115:Dimethindene / Q000652:urine*; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
D004115:Dimethindene