title: Cerebral blood flow and magnetic resonance imaging in locked-in syndrome.
abstract: The cerebral blood flow (CBF) of a patient suffering from locked-in syndrome (LiS) was examined before and after the onset using 99mTc-hexamethylpropyleneamine oxime single-photon emission computed tomography (SPECT) and the intravenous 133Xe injection method. The mean CBF during the locked-in state was 32.2 ml/100 g/min, a 42% reduction from the asymptomatic stage. SPECT showed profound reductions of perfusion in the bilateral cerebral cortices, subcortical regions and in the cerebellum, with a less marked reduction in the frontal cortices. On Day 49, the patient showed some minimal voluntary return with a moderate increase in mean CBF of 40.2 ml/100 g/min. The relative CBF values in the cerebral cortices and subcortical regions were restored, but the bilateral cerebellar hypoperfusion remained unchanged. SPECT and CBF are useful for a better characterization of the brain pathophysiology in LiS.
authors.affiliation: Department of Nuclear Medicine, Osaka National Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Isaka
authors.forename: O
authors.initials: O
authors.lastname: Iiji
authors.forename: K
authors.initials: K
authors.lastname: Ashida
authors.forename: M
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Y
authors.initials: Y
authors.lastname: Itoi
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D011782:Quadriplegia / Q000473:pathology / Q000503:physiopathology*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D014980:Xenon Radioisotopes; D019690:Technetium Tc 99m Exametazime