Metabolism and pharmacokinetics of deuterium-labelled di-2-(ethylhexyl) adipate (DEHA) in humans.
The metabolism and pharmacokinetics of [2H10]di-2-(ethylhexyl) adipate (DEHA) labelled on the ethyl side-chains was determined in six male volunteers. The dose administered was 46 mg [2H10]DEHA given orally. No parent molecule was found in plasma; however, the metabolite [2H5]2-ethylhexanoic acid (EHA) was detected (mean rate of formation: 1.63 +/- 1.19/hr; mean rate of elimination: 0.42 +/- 0.1/hr). Further oxidative metabolism products were detected in urine; the dominant metabolite identified was EHA present as a conjugate and accounted for an average of 8.6% of the administered dose. [2H5]2-Ethyl-5-hydroxyhexanoic acid, [2H5]2-ethylhexanedioic acid, [2H5]2-ethyl-5-keto-hexanoic acid and [2H5]2-ethylhexanol together accounted for a further 3.5% of the dose. The fate of the remainder was not determined.
Loftus
N J
NJ
Zeneca Central Toxicology Laboratory, Investigative Toxicology Section, Macclesfield, Cheshire, UK.
Laird
W J
WJ
Steel
G T
GT
Wilks
M F
MF
Woollen
B H
BH
D000272:Adipates / Q000378:metabolism* / Q000493:pharmacokinetics; D002845:Chromatography; D003903:Deuterium; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D010968:Plasticizers / Q000378:metabolism* / Q000493:pharmacokinetics
D000272:Adipates; D010968:Plasticizers; C013966:dioctyl adipate; D003903:Deuterium