title: Structural basis for mitral valve dysfunction associated with ostium secundum atrial septal defects.
abstract: Mitral valve (MV) specimens obtained at operation from 50 patients with ostium secundum atrial septal defect and associated MV dysfunction were studied macro- and microscopically to evaluate the structural lesions. The functional abnormalities in these patients were isolated mitral stenosis, isolated mitral regurgitation, mitral valve prolapse or mitral stenosis with regurgitation. Post-inflammatory lesions were commonly found in those with mitral stenosis who had a past history of rheumatic fever. Patients with mitral valve prolapse had either post-inflammatory lesions or lesions attributable to haemodynamic stress but different from the extensive lesions seen in floppy MV syndrome.
authors.affiliation: Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
authors.forename: J
authors.initials: J
authors.lastname: Joy
authors.forename: C C
authors.initials: CC
authors.lastname: Kartha
authors.forename: K G
authors.initials: KG
authors.lastname: Balakrishnan
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery