title: [Efficacy of myocardial preservation using HTK solution in continuous 120 min cross-clamping method--a comparative study with GIK method].
abstract: The aim of this study is to investigate the efficacy of HTK solution in the 120 minutes cross-clamping method in comparison with conventional intermittent cardioplegia using GIK solution. Fifty-four open heart surgery were performed with cardioplegic solution using either HTK solution (HTK) or GIK solution (GIK). In the HTK, HTK (3L) was infused for the initial dose and 1L was added every 60 min after 120 min of cross-clamping. In GIK, 1L of GIK solution was intermittently infused initially and then every 30 min together with continuous cold blood perfusion. The effect of two cardioplegic solution was evaluated by postoperative cardiac function (CI, %SF), released enzymes (CPK), histology and dosage of catecholamine. Postoperative CI was 3.67 +/- 0.76 in HTK, and 4.34 +/- 1.04 in GIK (NS). % SF was 26.0 +/- 5.26 in HTK and 25.6 +/- 0.76 in HTK, and 4.34 +/- 1.04 in GIK (NS). %SF was 26.0 +/- 5.26 in HTK and 25.6 +/- 9.2 in GIK (NS). The CK-MB (IU/dl) level after reperfusion was significantly decreased in HTK at 60 and 180 min after reperfusion. Histology at 60 min of ischemia revealed a significant increase of edema of mitochondria in GIK. Postoperative catecholamine dose was 2.65 +/- 1.3 in HTK and 10.3 +/- 3.4 in GIK (p < -0.01). PH of myocardium was well maintained around 7.4 during cross-clamping in HTK, however, it was decreased in GIK. In conclusion, The HTK method offers a reliable cardiac protection due to effective buffering using Histidine in comparison with GIK.
authors.affiliation: Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Hachida
authors.forename: Y
authors.initials: Y
authors.lastname: Bonkohara
authors.forename: M
authors.initials: M
authors.lastname: Nonoyama
authors.forename: A
authors.initials: A
authors.lastname: Toyama
authors.forename: S
authors.initials: S
authors.lastname: Saitou
authors.forename: S
authors.initials: S
authors.lastname: Nemoto
authors.forename: M
authors.initials: M
authors.lastname: Satou
authors.forename: T
authors.initials: T
authors.lastname: Katsumata
authors.forename: M
authors.initials: M
authors.lastname: Imamaki
authors.forename: H
authors.initials: H
authors.lastname: Koyanagi
mesh_terms: D002314:Cardioplegic Solutions; D005069:Evaluation Studies as Topic; D005947:Glucose; D006324:Heart Arrest, Induced; D006349:Heart Valve Diseases / Q000601:surgery; D006801:Humans; D007328:Insulin; D008353:Mannitol; D011188:Potassium; D011189:Potassium Chloride; D011343:Procaine
chemical_list: C039984:Bretschneider cardioplegic solution; D002314:Cardioplegic Solutions; D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D008353:Mannitol; D011343:Procaine; D011189:Potassium Chloride; D005947:Glucose; D011188:Potassium