title: Enhanced c-fos expression after intracellular iron deprivation.
abstract: Intracellular iron deprivation by deferoxamine treatment, which leads to cells arrest in the S phase, enhanced c-fos expression in the neuroblastoma cell line, IMR32. The c-fos expression of iron deprived cells retained its response to stimulation by TPA, and cytosolic PKC activity did not decline after iron deprivation. The data suggest that PKC was not down-regulated. Creatine kinase activity also remained constant in the cytosol of iron deprived cells, indicating intact cellular function. Iron deprivation may activate the growth-related oncogene, c-fos, through some means other than the PKC pathway.
authors.affiliation: Showa University, School of Medicine, Department of Clinical Pathology, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fukuchi
authors.forename: S
authors.initials: S
authors.lastname: Tomoyasu
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Takagi
authors.forename: N
authors.initials: N
authors.lastname: Tsuruoka
authors.forename: K
authors.initials: K
authors.lastname: Gomi
mesh_terms: D003402:Creatine Kinase / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D003676:Deferoxamine / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D016762:Genes, fos; D007501:Iron / Q000502:physiology*; D009447:Neuroblastoma / Q000473:pathology; D011493:Protein Kinase C / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D007501:Iron; D011493:Protein Kinase C; D003402:Creatine Kinase; D003676:Deferoxamine; D013755:Tetradecanoylphorbol Acetate