Renal failure attributable to atrophic glomerulopathy in four related rottweilers.
Atrophic glomerulopathy resulting in chronic renal failure was diagnosed in 4 related Rottweilers, each < 1 year old. All 4 dogs had severe azotemia and massive protein-losing nephropathy. Histologically, the glomerular lesion was characterized by mild dilatation of Bowman's space, with glomerular tufts absent or markedly atrophied. The lesion is distinct from the congenital glomerular changes described in Samoyeds or Doberman Pinschers.
Cook
S M
SM
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
Dean
D F
DF
Golden
D L
DL
Wilkinson
J E
JE
Means
T L
TL
D000818:Animals; D001284:Atrophy; D004283:Dog Diseases / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D007674:Kidney Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D010375:Pedigree; D011507:Proteinuria / Q000209:etiology / Q000473:pathology / Q000662:veterinary*