title: Protein S deficiency in a patient with necrotizing cellulitis.
abstract: A case of necrotizing cellulitis of the penis is reported. In this patient, transient functional protein S deficiency during the infectious process was demonstrated with a marked decrease of free protein S and elevated C4b-binding protein levels. Moreover, by investigating other members of this patient's family it was possible to demonstrate a subclinical inherited protein S deficiency. In this study it is suggested that the profound and transient decrease of functional protein S observed in this patient during infectious cellulitis, may have contributed to the pathogenesis of tissue necrosis.
authors.affiliation: Department of Dermatology, Hôpital Henri Mondor, Créteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Joly
authors.forename: O
authors.initials: O
authors.lastname: Chosidow
authors.forename: M
authors.initials: M
authors.lastname: Gouault-Heilmann
authors.forename: M
authors.initials: M
authors.lastname: Levent
authors.forename: J C
authors.initials: JC
authors.lastname: Roujeau
authors.forename: J
authors.initials: J
authors.lastname: Revuz
mesh_terms: D000328:Adult; D002481:Cellulitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008297:Male; D009336:Necrosis; D010409:Penile Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010413:Penis / Q000473:pathology; D018455:Protein S Deficiency