title: A new hypothesis: iodine and gastric cancer.
abstract: The authors have hypothesized that iodine-deficiency (I-def) or in some cases iodine-excess (I-excess) is associated with the development of gastric cancer. They report a short review of their own work and general literature on this subject in three fields: (1) epidemiology, where geographical and temporal correlations between territories with I-def (or I-excess) endemic goitre and high GC-death rate are reported; (2) immunology, where the possible correlations between I-def, immune-deficiency and GC are reported; and (3) thyroid gland and stomach correlations, both being embryologically derived from primitive gut and able to concentrate iodine. This ability is impaired by nitrates, thiocyanate, salt and by I-excess, which in fact can cause goitre. In our study I-def goitrous people have shown more atrophic gastritis than normal subjects. These data enable us to hypothesize that I-def or I-excess might constitute a new risk factor for gastric cancer, both by regulating gastric trophism and by antagonizing the action of those I-inhibitors (such as nitrates, thiocyanate and salt) previously studied as risk factors for gastric cancer.
authors.affiliation: Servizio di Igiene e Sanita Pubblica, USL N1, Regione Marche, Novafeltria (PS), Italy.
authors.forename: S
authors.initials: S
authors.lastname: Venturi
authors.forename: A
authors.initials: A
authors.lastname: Venturi
authors.forename: D
authors.initials: D
authors.lastname: Cimini
authors.forename: C
authors.initials: C
authors.lastname: Arduini
authors.forename: M
authors.initials: M
authors.lastname: Venturi
authors.forename: A
authors.initials: A
authors.lastname: Guidi
mesh_terms: D005260:Female; D005757:Gastritis, Atrophic / Q000150:complications / Q000378:metabolism*; D006042:Goiter / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000187:drug effects; D007455:Iodine / Q000032:analysis / Q000172:deficiency* / Q000494:pharmacology; D008297:Male; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007455:Iodine