title: Trisomy 4 may occur in a broad range of hematologic malignancies.
abstract: Trisomy 4 is an uncommon numerical chromosomal aberration in acute leukemia. We describe three cases of trisomy 4, occurring in two patients with acute myeloid leukemia (M1 and M5a) and in one patient with T-cell acute lymphoblastic leukemia. Our results suggest that trisomy 4 may occur in a broader range of hematologic and malignancies than previously described.
authors.affiliation: Haematology Section, University Department of Pathology, Queen Mary Hospital, Hong Kong.
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
authors.forename: S Y
authors.initials: SY
authors.lastname: Ha
authors.forename: H W
authors.initials: HW
authors.lastname: Liu
authors.forename: L C
authors.initials: LC
authors.lastname: Chan
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014314:Trisomy