title: Pulp capping with Bioglass and autologous demineralized dentin in miniature swine.
abstract: The purpose of this study was to compare the responses of mechanically exposed dental pulps which had been capped with three dissimilar materials: a bioactive ceramic (Bioglass), autologous demineralized dentin matrix (DDM), and a calcium hydroxide product (Life), with Teflon discs as controls. Mechanical dental pulp exposures were made after preparation of deep buccal Class V cavities in 48 teeth in four miniature swine. The exposures were capped and the cavity preparations restored with zinc oxide-eugenol (IRM) cement. The animals were killed after 90 days, the coronal 2/3 of the teeth removed, and sections prepared for either histological or microradiographic examination. The pulpal inflammatory reactions and the degree of reparative dentin formation were assessed from demineralized serial sections. A qualitative assessment of the degree of mineralization of the reparative dentin was made from microradiographs of undecalcified sections. The observations suggest that reparative dentin formation occurs under a variety of pulp-capping materials, but the structure of the reparative dentin varies with the material and the condition of the underlying pulp.
authors.affiliation: University of Florida Health Science Center, Department of Endodontics, Gainesville 32610-0436.
authors.forename: B
authors.initials: B
authors.lastname: Oguntebi
authors.forename: A
authors.initials: A
authors.lastname: Clark
authors.forename: J
authors.initials: J
authors.lastname: Wilson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002126:Calcium Hydroxide / Q000494:pharmacology*; D002516:Ceramics / Q000494:pharmacology*; D003764:Dental Materials / Q000494:pharmacology*; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000379:methods*; D003790:Dental Pulp Necrosis / Q000139:chemically induced; D003804:Dentin; D003809:Dentin, Secondary / Q000648:ultrastructure; D013552:Swine; D013556:Swine, Miniature
chemical_list: C022107:Bioglass; D003764:Dental Materials; C040408:Life (dental material); D002126:Calcium Hydroxide