title: Adenosine-sensitive ventricular tachycardia. Clinical characteristics and response to catheter ablation.
abstract: BACKGROUND
  Sustained ventricular tachycardia in the absence of structural heart disease may have diverse mechanisms. Termination of the tachycardia by adenosine suggests triggered automaticity as the etiology in many of these patients. We examined the clinical characteristics, electrophysiological responses, and results of catheter ablation in this patient subgroup.
  
  
  RESULTS
  Intravenous adenosine terminated sustained ventricular tachycardia in seven of 14 consecutive patients without evidence of structural heart disease. In each of these patients, the tachycardia had a left bundle branch block, inferior-axis QRS configuration and occurred predominantly during stress or exertion. A morphologically similar sustained tachycardia was induced in six of seven patients during programmed ventricular stimulation, although day-to-day reproducibility was poor. Signal-averaged ECGs were normal in all patients. Imaging with 123I-metaiodobenzylguanidine did not reveal focal abnormalities in any of five patients. A discrete site of origin was identified in the free wall of the pulmonary infundibulum in all patients. Limited application of direct current shocks (two patients) or radiofrequency energy (five patients) resulted in long-term abolition of spontaneous and inducible ventricular tachycardia in all patients.
  
  
  CONCLUSIONS
  Adenosine-sensitive ventricular tachycardia appears to arise from relatively discrete sites predominantly located in the free wall of the pulmonary infundibulum. The localized nature of this tachycardia renders it amenable to long-term cure by catheter ablation techniques.
authors.affiliation: Section of Cardiology, Loyola University Medical Center, Maywood, Ill 50153.
authors.forename: D J
authors.initials: DJ
authors.lastname: Wilber
authors.forename: J
authors.initials: J
authors.lastname: Baerman
authors.forename: B
authors.initials: B
authors.lastname: Olshansky
authors.forename: J
authors.initials: J
authors.lastname: Kall
authors.forename: D
authors.initials: D
authors.lastname: Kopp
mesh_terms: D000241:Adenosine / Q000627:therapeutic use*; D000328:Adult; D006328:Cardiac Catheterization; D004594:Electrophysiology; D004598:Electrosurgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D017180:Tachycardia, Ventricular / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery
chemical_list: D000241:Adenosine