Organum vasculosum laminae terminalis (OVLT) is a brain site to produce interleukin-1 beta during fever.
The present study was carried out to determine whether interleukin-1 (IL-1) production occurs in the rabbit organum vasculosum laminae terminalis (OVLT) during fever induced by endotoxin. The intravenous (i.v.) injection of endotoxin (4 micrograms/kg) caused significant fever in rabbits. Through the use of in situ hybridization and immunohistochemical techniques, the synthesis of IL-1 was observed in the OVLT during the fever. The present results support the hypothesis that IL-1 is produced in the brain during fever.
Nakamori
T
T
Department of Physiology, Yamaguchi University School of Medicine, Japan.
Morimoto
A
A
Yamaguchi
K
K
Watanabe
T
T
Long
N C
NC
Murakami
N
N
D000818:Animals; D002552:Cerebral Ventricles / Q000378:metabolism*; D004731:Endotoxins; D005334:Fever / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides; D008297:Male; D011817:Rabbits; D012485:Salmonella typhi
D004731:Endotoxins; D007375:Interleukin-1; D008070:Lipopolysaccharides