title: Chronic dementia in Parkinson's disease treated by anticholinergic agents. Neuropsychological and neuroradiological examination.
abstract: Reports about chronic-onset dementia due to ACA have been rare. Here we described five patients with chronic dementia induced by ACA. We examined their clinical aspect, neuropsychological aspect, and neuroradiological aspect in detail. Our study suggests the possibility of ACA-induced chronic-onset dementia in PD patients.
authors.affiliation: Department of Neurology, Japanese Red Cross Medical Center, Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Nishiyama
authors.forename: T
authors.initials: T
authors.lastname: Mizuno
authors.forename: M
authors.initials: M
authors.lastname: Sakuta
authors.forename: H
authors.initials: H
authors.lastname: Kurisaki
mesh_terms: D000368:Aged; D001712:Biperiden / Q000009:adverse effects / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000098:blood supply* / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects; D003704:Dementia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000523:psychology; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D009483:Neuropsychological Tests; D010276:Parasympatholytics / Q000009:adverse effects* / Q000627:therapeutic use; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000523:psychology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D014282:Trihexyphenidyl / Q000009:adverse effects / Q000627:therapeutic use; D014888:Wechsler Scales
chemical_list: D001786:Blood Glucose; D010276:Parasympatholytics; D001712:Biperiden; D014282:Trihexyphenidyl