UK Prospective Diabetes Study (UKPDS). IX: Relationships of urinary albumin and N-acetylglucosaminidase to glycaemia and hypertension at diagnosis of type 2 (non-insulin-dependent) diabetes mellitus and after 3 months diet therapy.
In 672 newly-diagnosed, Type 2 (non-insulin-dependent) diabetic patients without urinary infection, aged 51 (9) years, mean (1 SD), 28% of patients had raised albuminuria, defined as albumin excretion greater than 25 mg/l and 66% raised urinary N-acetylglucosaminidase excretion defined as greater than 300 mumol.h-1.l-1 (both urinary analytes corrected by linear regression on urinary creatinine to 10 mmol/1). In a univariate analysis, urinary N-acetylglucosaminidase and albumin excretion correlated with each other (rs = 0.42, p < 0.001), and with fasting plasma glucose (rs = 0.46 and rs = 0.27, p < 0.001, respectively). The association of urinary albumin and N-acetylglucosaminidase remained significant after taking the fasting plasma glucose levels into account, partial rs = 0.34, p < 0.001. After 3 months of dietary therapy BMI decreased from 29.7 (5.9) kg/m2 to 28.8 (5.8) kg/m2, fasting plasma glucose levels from 12.2 (3.8) mmol/l to 9.8 (3.8) mmol/l, and systolic blood pressure from 143 (21.8) mmHg to 131 (20.3) mmHg, p < 0.001 for each variable. There were concomitant decreases in urinary N-acetylglucosaminidase, geometric mean (1 SD interval), 397 mumol.h-1.l-1 (216 to 728) to 291 mumol.h-1.l-1 (160 to 528), p < 0.001 and in albumin excretion 16 mg/l (5 to 51) to 13 mg/l (4 to 40), p < 0.001. The decrease in urinary N-acetylglucosaminidase, but not the decrease in urinary albumin excretion, was associated with the initial degree of glycaemia and the decrease in glycaemia in response to diet.(ABSTRACT TRUNCATED AT 250 WORDS)
D000118:Acetylglucosaminidase / Q000097:blood / Q000652:urine*; D000419:Albuminuria; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000178:diet therapy / Q000503:physiopathology*; D003927:Diet, Diabetic; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D013997:Time Factors; D006113:United Kingdom
D000118:Acetylglucosaminidase; D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin