title: Naturally occurring deuterium is essential for the normal growth rate of cells.
abstract: The role of naturally occurring D in living organisms has been examined by using deuterium-depleted water (30-40 ppm D) instead of water containing the natural abundance of D (150 ppm). The deuterium-depleted water significantly decreased the growth rate of the L929 fibroblast cell line, and also inhibited the tumor growth in xenotransplanted mice. Eighty days after transplantation in 10 (59%) out of 17 tumorous mice the tumor, after having grown, regressed and then disappeared. We suggest that the naturally occurring D has a central role in signal transduction involved in cell cycle regulation.
authors.affiliation: HYD Ltd. for Research and Development, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Somlyai
authors.forename: G
authors.initials: G
authors.lastname: Jancsó
authors.forename: G
authors.initials: G
authors.lastname: Jákli
authors.forename: K
authors.initials: K
authors.lastname: Vass
authors.forename: B
authors.initials: B
authors.lastname: Barna
authors.forename: V
authors.initials: V
authors.lastname: Lakics
authors.forename: T
authors.initials: T
authors.lastname: Gaál
mesh_terms: D000230:Adenocarcinoma; D000818:Animals; D001834:Body Water / Q000502:physiology; D001943:Breast Neoplasms; D002455:Cell Division / Q000502:physiology*; D002460:Cell Line; D016895:Culture Media, Serum-Free; D003903:Deuterium; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
chemical_list: D016895:Culture Media, Serum-Free; D003903:Deuterium