Immunoglobulin allotypic markers in Kawasaki disease.
We investigated the possible relationship of the distribution of immunoglobulin allotypic markers for susceptibility to Kawasaki disease in Japanese, Japanese-American, and white American populations. The kappa-chain allotype Km1 was present in 25.6% of sera from white patients with Kawasaki disease and in 14.4% of control sera (p < 0.01), and the combination of Km1 with Gm heterozygosity was present in 17.9% of white patients with Kawasaki disease and in 6.4% of control sera (p < 0.0001). In all populations studied, differences were observed between the patients with Kawasaki disease and the race-matched control subjects. The findings support the hypothesis that one or more unknown infectious agents may trigger genetically influenced immune responses that result in clinically recognizable Kawasaki disease.
Shulman
S T
ST
Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois.
Melish
M
M
Inoue
O
O
Kato
H
H
Tomita
S
S
D000328:Adult; D000483:Alleles; D001213:Asian / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002648:Child; D004198:Disease Susceptibility; D005799:Genes, Dominant; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000032:analysis / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000032:analysis / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000032:analysis / Q000235:genetics; D007137:Immunoglobulin alpha-Chains / Q000032:analysis / Q000235:genetics; D007142:Immunoglobulin gamma-Chains / Q000032:analysis / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000235:genetics; D007564:Japan / Q000208:ethnology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics / Q000276:immunology*; D014481:United States; D044465:White People / Q000235:genetics
D005819:Genetic Markers; D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007137:Immunoglobulin alpha-Chains; D007142:Immunoglobulin gamma-Chains; D007145:Immunoglobulin kappa-Chains