title: Clinical profile and outcome in enteric fever.
abstract: Sixty five blood culture positive cases of S. typhi were studied for clinical profile. A total of 64.6% were multidrug resistant and 35.4% were chloramphenicol sensitive. In patients with multidrug resistant S. typhi the age was higher (p < 0.01), and incidence of complications such as shock (35.7%), encephalopathy (42.9%), myocarditis (14.3%) and gastric hemorrhage (4.7%) were more frequent, compared to chloramphenicol sensitive group. Cases with multidrug resistant S. typhi (MDRST) were treated with oral ciprofloxacin; the period of defervescence of fever was significantly less (p < 0.05) compared to the chloramphenicol group. Our study suggests the use of ciprofloxacin in the treatment of MDRST without any side effects.
authors.affiliation: Department of Pediatrics, Medical College, Rohtak, Haryana.
authors.forename: A
authors.initials: A
authors.lastname: Sharma
authors.forename: G
authors.initials: G
authors.lastname: Gathwala
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D012485:Salmonella typhi; D014435:Typhoid Fever / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002939:Ciprofloxacin