Adaptation of Escherichia coli to redox environments by gene expression.
Escherichia coli is adroit in exploiting environmental energy sources to its greatest profit. A key strategy is to channel electron transport from donor to a terminal acceptor(s) so that the voltage drop is maximal. At the level of transcription, the goal is achieved by the interaction of three global regulatory systems, Fnr, NarL/NarX and ArcB/ArcA. In addition, the regulator FhlA is involved in a cascade-controlled pathway for the formate branch of the pyruvate fermentation pathway.
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Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.
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D000222:Adaptation, Physiological / Q000235:genetics*; D000332:Aerobiosis; D000693:Anaerobiosis; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins; D004579:Electron Transport; D004734:Energy Metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins; D005285:Fermentation; D015964:Gene Expression Regulation, Bacterial; D007506:Iron-Sulfur Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D010084:Oxidation-Reduction; D011494:Protein Kinases; D012097:Repressor Proteins; D014158:Transcription, Genetic
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C060704:FNR protein, E coli; D007506:Iron-Sulfur Proteins; D008565:Membrane Proteins; D012097:Repressor Proteins; C041610:arcA protein, E coli; C069780:NarL protein, E coli; D011494:Protein Kinases; C065271:arcB protein, E coli; C074787:narX protein, E coli