title: Long-term sulfamethoxazole-trimethoprim in Wegener's granulomatosis.
abstract: Since 1985, a number of reports have highlighted the effectiveness of a short course of sulfamethoxazole-trimethoprim as an adjuvant to immunosuppressive drugs in the treatment of Wegener's granulomatosis. We report our experience with long-term sulfamethoxazole-trimethoprim therapy in patients with Wegener's granulomatosis. We describe recent advances in the pathogenesis of Wegener's granulomatosis, suggest a complementary mechanism of action of sulfamethoxazole-trimethoprim, and advocate long-term sulfamethoxazole-trimethoprim therapy as a treatment option in Wegener's granulomatosis.
authors.affiliation: Ear, Nose, and Throat Department, Southend Hospital, Westcliff-on-Sea, England.
authors.forename: D
authors.initials: D
authors.lastname: McRae
authors.forename: G
authors.initials: G
authors.lastname: Buchanan
mesh_terms: D000328:Adult; D000368:Aged; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination