Pathogenesis of SIVmac251 after atraumatic inoculation of the rectal mucosa in rhesus monkeys.
Intrarectal inoculation of rhesus monkeys with low doses of SIVmac led to a prolonged clinical and virological latency that was not observed for high intrarectal doses or for intravenous inoculation. Animals infected intrarectally with low virus doses remained negative for serum antibody responses to SIV for at least one year even though they readily transferred SIV to naive recipients via transfusion of whole blood.
Pauza
C D
CD
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53706.
Emau
P
P
Salvato
M S
MS
Trivedi
P
P
MacKenzie
D
D
Malkovsky
M
M
Uno
H
H
Schultz
K T
KT
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D004195:Disease Models, Animal; D015658:HIV Infections / Q000635:transmission; D015497:HIV-1; D007413:Intestinal Mucosa / Q000382:microbiology; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008253:Macaca mulatta; D008297:Male; D008969:Molecular Sequence Data; D012007:Rectum / Q000382:microbiology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000635:transmission; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D013997:Time Factors
D000914:Antibodies, Viral; D004279:DNA, Viral