title: The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q.
abstract: The autosomal Booroola fecundity gene (FecB) mutation in sheep increases ovulation rate and litter size, with associated effects on ovarian physiology and hormone profiles. Analysis of segregation in twelve families (379 female progeny) identified linkage between the mutation, two microsatellite markers (OarAE101 and OarHH55, Zmax > 9.0) and epidermal growth factor (EGF) from human chromosome 4q25 (Zmax > 3.0). The marker OarAE101 was linked to secreted phosphoprotein 1 (SPP1, which maps to chromosome 4q21-23 in man) in the test pedigrees and independent families (Zmax > 9.7). The identification of linkage between the FecB mutation and markers from human chromosome 4q is an important step towards further understanding the control of ovulation rates in mammals.
authors.affiliation: Department of Biochemistry, University of Otago, Dunedin, New Zealand.
authors.forename: G W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: A M
authors.initials: AM
authors.lastname: Crawford
authors.forename: J M
authors.initials: JM
authors.lastname: Penty
authors.forename: K G
authors.initials: KG
authors.lastname: Dodds
authors.forename: A J
authors.initials: AJ
authors.lastname: Ede
authors.forename: H M
authors.initials: HM
authors.lastname: Henry
authors.forename: C A
authors.initials: CA
authors.lastname: Pierson
authors.forename: E A
authors.initials: EA
authors.lastname: Lord
authors.forename: S M
authors.initials: SM
authors.lastname: Galloway
authors.forename: A E
authors.initials: AE
authors.lastname: Schmack
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D015342:DNA Probes; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D005298:Fertility / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D009838:Oligodeoxyribonucleotides; D010641:Phenotype; D011995:Recombination, Genetic; D012756:Sheep / Q000235:genetics*
chemical_list: D015342:DNA Probes; D004276:DNA, Satellite; D005819:Genetic Markers; D009838:Oligodeoxyribonucleotides