Strain differences in susceptibility to di-2-ethylhexyl phthalate-induced testicular atrophy in mice.
It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular injury. This atrophy was accompanied by lowered zinc concentration and lactate dehydrogenase isozyme X in the testis. This fact and the effect of genetic background will need to be considered for assessing the risk of testicular toxicity in men exposed to phthalate esters.
Oishi
S
S
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects; D012680:Sensitivity and Specificity; D013045:Species Specificity; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology*; D015032:Zinc / Q000378:metabolism
D007527:Isoenzymes; D004051:Diethylhexyl Phthalate; D007770:L-Lactate Dehydrogenase; D015032:Zinc