[The role of cytokines in normal and in leukemic hematopoiesis].
There have been astonishing advances in the field of cytokines in recent years. In the present paper we focus on a few hematopoietic cytokines and discuss some aspects of the biology and pathophysiology of cytokines and their receptors in normal and leukemic hematopoiesis. We also address future developments and in particular the role of negative stem cell regulators.
Tobler
A
A
Hämatologisches Zentrallabor der Universität, Inselspital Bern.
D000818:Animals; D003115:Colony-Stimulating Factors / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006410:Hematopoiesis; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006801:Humans; D007378:Interleukins / Q000502:physiology; D007938:Leukemia / Q000097:blood*; D016184:Receptors, Colony-Stimulating Factor / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D003115:Colony-Stimulating Factors; D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors; D007378:Interleukins; D016184:Receptors, Colony-Stimulating Factor; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor