Postirradiation administration of adenosine monophosphate combined with dipyridamole reduces early cellular damage in mice.
The administration of dipyridamole and adenosine 5'-monophosphate (AMP) to mice 5 to 25 min after 1 Gy of total-body gamma irradiation was found to decrease cellular damage, as indicated by the thymidine level in plasma and the amount of saline soluble polynucleotides in the thymus. The drug combination used did not influence similar cytotoxic effects of hydrocortisone. Furthermore, it was shown that the addition of dipyridamole and AMP to in vitro irradiated suspensions of thymocytes enhanced the rejoining processes of DNA strand breaks. Receptor-mediated action of extracellular adenosine may be responsible for the therapeutic effects observed.
Bohácek
J
J
Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno.
Hosek
B
B
Pospísil
M
M
D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D004249:DNA Damage / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013936:Thymidine / Q000097:blood; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D000249:Adenosine Monophosphate; D004176:Dipyridamole; D013936:Thymidine; D006854:Hydrocortisone