[Comparison of therapeutic value of various topical agents in Pseudomonas aeruginosa infection. An experimental study].
40 Wistar rats were scalded by boiling water for 12 seconds resulting to 10% TBSA full-thickness burn. Pseudomonas aeruginosa (10(9)/ml) was smeared on the burn wounds 10 min after injury. The animals were divided into 4 groups. Sulfadiazine silver and sulfadiazine zinc (with 5% azone) cream was applied to the wounds of animals in the group 1. The contaminated wounds were irradiated with negative ion current in the group 2. The "moisture ointment" was applied to the wounds in the group 3. Group 4 consisted of the controls without any treatment. All the topical agents were applied to the wounds 4 hr after the injury. The number of bacteria in the subeschar tissue was determined every day for 4 days. The tissues of lung, kidney, liver and heart were examined pathologically on the 4th day. The results showed that the quantity of bacteria in the subeschar tissue was significantly less, and pathological changes in organs were significantly milder in the 1st and 2nd groups than other two groups. The "moisture ointment" group yielded the poorest results in respect to subeschar bacterial counts and visceral pathology.
Guo
Z R
ZR
304th Hospital of PLA.
D000287:Administration, Topical; D000818:Animals; D001381:Azepines / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy / Q000382:microbiology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D013411:Sulfadiazine / Q000627:therapeutic use; D015032:Zinc
D001381:Azepines; D004365:Drugs, Chinese Herbal; D013411:Sulfadiazine; C035229:laurocapram; D015032:Zinc; D012837:Silver Sulfadiazine