A complex translocation, t(4;11;13)(q21;q23;q12-14), in a case of infantile acute lymphoblastic leukemia.
Cytogenetic analysis provides valuable prognostic information in children diagnosed with hematologic malignancies. While the t(4;11)(q21;q23) has frequently been reported in patients with acute lymphoblastic leukemia, the additional involvement of chromosome 13 to form a three-way translocation has not been described previously. We report a case of acute lymphoblastic leukemia in a 5-month old infant with a complex t(4;11;13)(q21;q23;q12-14).
Matsunaga
A T
AT
Department of Hematology-Oncology, Oakland Children's Hospital, CA 94609.
Torfi
H
H
Feusner
J
J
D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007621:Karyotyping; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D014178:Translocation, Genetic