title: [Histopathology and ultrastructural changes of the musculature and nerves during methamidophos toxication in chicken].
abstract: After exposure to methamidophos (Via digestive or respiratory tract or just by skin contamination) for 1, 2, 3, 4, 8 and 12 weeks respectively, ultrastructure of the myofibrils in chicken with methamidophos toxication via the digestive tract showed mild degeneration in the first week and serious degeneration by the end of the fourth week. Light microscopy of the muscle-fibril showed atrophy and necrosis in the third week, including both myopathic atrophy and neuropathic atrophy. Recovery of the lesions took place from the 8th to the 12th week (Light or elcetion microscopy). Those chickenstaking immunosuppressive drug simultaneously with methamidophos exposure (via digestive tract) showed less degeneration of the myofibrils and nerves. Ultrastructure of the myofibril in chickens with methamidophos intoxication through the respiratory tract also developed less degeneration of myofibrils and nerves than those obtained through digestive intoxication. There was no lesion obtained in chicken taking methamidophos via the respiratory tract coexistently with the immunosuppressive drug or just by skin contamination.
authors.affiliation: Second Affiliated Hospital, Nanjing Medical college.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000818:Animals; D001284:Atrophy; D002645:Chickens; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D009210:Myofibrils / Q000187:drug effects; D009336:Necrosis; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; C014655:methamidophos