[Comparison of anti-inflammatory, analgesic activities, anaphylactogenicity and acute toxicity between bee venom and its peptides].
Bee venom 1.0-2.0 mg/kg and bee venom peptides 1.0-2.0 mg/kg inhibited several inflammatory processes, such as ear swelling induced by xylene in mice, edema produced by injecting 1% carrageenin 0.1 ml beneath the plantar surface of hind paw in rats and showed a marked analgesic action induced by the hot plate and potassium antimony tartrate. Bee venom peptides had a markedly more effective action as compared with bee venom itself. The anaphylactogenicity of bee venom peptides was apparently milder than that of bee venom. The LD50 of bee venom ip in mice and bee venom peptides was 7.4 mg/kg and 7.9 mg/kg respectively.
Chen
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CY
Nanjing Institute of Biochemical Pharmacy.
Chen
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WX
Sun
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D000485:Allergens; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001514:Bee Venoms / Q000276:immunology / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D008555:Melitten / Q000276:immunology / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000485:Allergens; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001514:Bee Venoms; D008555:Melitten