title: Concurrent HPV-16 infection of the nipple and perianal area in an HIV-1+ patient. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR)
abstract: BACKGROUND
  In patients with HIV-1 disease there has been an increasing association with human papilloma virus (HPV) infections in multiple locations as well as an increase in associated tumors. In addition, there has been increased recovery of HPV in individuals with decreasing T4 cell counts.
  
  
  METHODS
  Recently we have seen an HIV-1+ patient with a cutaneous lesion on the nipple, as well as multiple perianal lesions in which HPV-16 was demonstrated by in-situ hybridization. Although these lesions contained the same subtype of HPV virus, they had very different clinical and histopathologic morphologies, and this represents the first reported association of HPV-16 in a nipple lesion.
  
  
  CONCLUSIONS
  Our patient illustrates that in HIV-1 disease, HPV infections may present in more diffuse and atypical locations. In addition, the diffuse staining with the in-situ probe for HIV-16 within the lesions, tends to support the findings of others, that viral recovery increases with the immune suppression induced by HIV-1.
authors.affiliation: Department of Dermatology, Walter Reed Army Medical Center, Bethesda, MD.
authors.forename: K J
authors.initials: KJ
authors.lastname: Smith
authors.forename: H G
authors.initials: HG
authors.lastname: Skelton
authors.forename: C
authors.initials: C
authors.lastname: Hawks
authors.forename: J
authors.initials: J
authors.lastname: Yeager
authors.forename: K F
authors.initials: KF
authors.lastname: Wagner
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000473:pathology*; D000328:Adult; D001004:Anus Diseases / Q000382:microbiology / Q000473:pathology*; D001941:Breast Diseases / Q000382:microbiology / Q000473:pathology; D015497:HIV-1; D006801:Humans; D008297:Male; D009558:Nipples / Q000473:pathology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*