Familial meningioma is not allelic to neurofibromatosis 2.
Meningiomas frequently lose parts of chromosome 22 (CHR 22), suggesting that a meningioma tumor-suppressor gene is located on CHR 22. Since meningiomas are common in neurofibromatosis 2 (NF2) and the NF2 gene is mapped to CHR 22, the NF2 gene is a candidate for the meningioma gene. To determine whether NF2 and familial meningioma are allelic mutations, we studied a family with multiple meningiomas and ependymomas in two generations using genetic linkage analysis with DNA markers known to flank the NF2 locus. Multipoint linkage analysis resulted in location scores < -2 for a region of 15 cM including the NF2 region. These results support the existence of a familial meningioma locus that is distinct from the NF2 locus.
Pulst
S M
SM
Neurogenetics Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048-0750.
Rouleau
G A
GA
Marineau
C
C
Fain
P
P
Sieb
J P
JP
D000483:Alleles; D001483:Base Sequence; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D017931:DNA Primers; D015342:DNA Probes; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D008969:Molecular Sequence Data; D016518:Neurofibromatosis 2 / Q000235:genetics*; D010375:Pedigree; D012984:Software
D017931:DNA Primers; D015342:DNA Probes; D004276:DNA, Satellite; D005819:Genetic Markers