Enhancing factor protein from mouse small intestines belongs to the phospholipase A2 family.
Enhancing factor (EF), a growth regulatory molecule, isolated from mouse small intestines, has been well characterized in this laboratory. It increases the binding of epidermal growth factor in a unique manner via its own receptor. In the first 20 N-terminal amino acids sequenced, EF showed 50% homology to human Group II phospholipase A2 (PLA2). Here we propose that EF is yet another, unidentified isoform of PLA2 which regulates cell proliferation via modulation of EGF binding. To our knowledge, this is the first report implicating PLA2-II-like molecules in growth regulation.
Mulherkar
R
R
Cell and Developmental Pathology Division, Tata Memorial Centre, Bombay, India.
Rao
R
R
Rao
L
L
Patki
V
V
Chauhan
V S
VS
Deo
M G
MG
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D054501:Group II Phospholipases A2; D007421:Intestine, Small / Q000737:chemistry*; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D010741:Phospholipases A / Q000737:chemistry* / Q000378:metabolism; D054467:Phospholipases A2; D017386:Sequence Homology, Amino Acid
D010455:Peptides; D010741:Phospholipases A; D054501:Group II Phospholipases A2; D054467:Phospholipases A2; C516288:Pla2g2a protein, mouse