Cardiac arrhythmias after inhaled bronchodilators in patients with COPD and ischemic heart disease.
Selective beta 2-agonist aerosols may produce significant cardiovascular effects. In the present study we used Holter monitoring to compare the arrhythmogenic effects of inhaled terbutaline (TE), a beta 2-agonist, with that of ipratropium bromide (IB), a nonabsorbable cholinergic drug. Fourteen patients with concomitant obstructive lung disease, ischemic heart disease, and complaints of postinhalation palpitations were studied in a random, double-blind, cross-over fashion. Both drugs significantly improved vital capacity and FEV1. Heart rate and the frequency of premature beats were not significantly affected by the bronchodilators. We conclude that no clear connection between inhaled bronchodilators and arrhythmias could be demonstrated.
Seider
N
N
Department of Medicine B, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
Abinader
E G
EG
Oliven
A
A
D000280:Administration, Inhalation; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis; D004311:Double-Blind Method; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage / Q000009:adverse effects*; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy*; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications*; D013726:Terbutaline / Q000008:administration & dosage / Q000009:adverse effects*
D009241:Ipratropium; D013726:Terbutaline