The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory.
Angiotensin II(1-8) (A II) and its fragments: angiotensin III(2-8) (A III), angiotensin IV(3-8) (AIV), angiotensin V (4-8) (A V) and angiotensin VI(3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.
Wiśniewski
K
K
Department of Pharmacology, Medical Academy, Białystok, Poland.
Borawska
M
M
Car
H
H
D000437:Alcoholism / Q000523:psychology; D000804:Angiotensin II / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013894:Thirst / Q000187:drug effects
D000804:Angiotensin II