title: Production of mucinase and neuraminidase and binding of Shigella to intestinal mucin.
abstract: Production of mucinase and neuraminidase by Shigella spp. and their ability to bind to mucin was investigated. All four species of Shigella produced these enzymes. Virulent and avirulent pairs of Shigella did not differ in their ability to produce the enzymes after 18 h of growth. However, a significant difference in neuraminidase production was noted in Shigella dysenteriae type 1 and S. boydii (12-15) at 10 h growth. Avirulent strains of S. dysenteriae type 1, S. flexneri 2a, and S. boydii bound significantly more amounts of mucin than their virulent counterparts.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
authors.forename: K
authors.initials: K
authors.lastname: Haider
authors.forename: A
authors.initials: A
authors.lastname: Hossain
authors.forename: C
authors.initials: C
authors.lastname: Wanke
authors.forename: F
authors.initials: F
authors.lastname: Qadri
authors.forename: S
authors.initials: S
authors.lastname: Ali
authors.forename: S
authors.initials: S
authors.lastname: Nahar
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007422:Intestines / Q000382:microbiology; D009077:Mucins / Q000378:metabolism*; D009439:Neuraminidase / Q000096:biosynthesis; D011133:Polysaccharide-Lyases / Q000096:biosynthesis; D011817:Rabbits; D012760:Shigella / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D009077:Mucins; D009439:Neuraminidase; D011133:Polysaccharide-Lyases; C100002:hyaluronate lyase