The biology of interleukin 11.
Interleukin 11 (IL-11) is a multifunctional cytokine which may play a role in regulating the growth and development of cells in both the hematopoietic and lymphoid systems. IL-11 activity was originally detected in the conditioned medium of a primate bone marrow stromal cell line, and the human cDNA was cloned from a human fetal lung fibroblast cell line. The purified protein shows multifunctional activity, influencing lymphohematopoietic stem cell proliferation and differentiation, megakaryocyte progenitor cell proliferation and differentiation, erythroid progenitor cell proliferation, B lymphocyte maturation, activation of hepatocyte acute phase protein synthesis, and adipogenesis. At the molecular level, IL-11 is unique, containing no asparagine-linked glycosylation sites and no cysteine residues. The IL-11 receptor belongs to a family of cytokine receptors which includes the receptors for IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF), which are all capable of interacting with the signal transducing receptor gp130 after ligand binding. IL-11 has demonstrated activity in preclinical models for the treatment of thrombocytopenia and, in some cases, neutropenia; studies are underway to confirm its usefulness in the clinic for treatment of myelosuppression associated with cancer chemotherapy and bone marrow transplantation.
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Genetics Institute, Inc., Cambridge, MA 02140.
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D000818:Animals; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005796:Genes; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D017370:Interleukin-11 / Q000235:genetics / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D053703:Interleukin-11 Receptor alpha Subunit; D015850:Interleukin-6 / Q000502:physiology; D008221:Lymphoid Tissue / Q000187:drug effects; D051379:Mice; D009503:Neutropenia / Q000628:therapy; D011323:Primates / Q000235:genetics; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism; D053702:Receptors, Interleukin-11; D012689:Sequence Homology, Nucleic Acid; D013921:Thrombocytopenia / Q000628:therapy
C508428:IL11RA protein, human; C508429:Il11ra1 protein, mouse; D007155:Immunologic Factors; D017370:Interleukin-11; D053703:Interleukin-11 Receptor alpha Subunit; D015850:Interleukin-6; D018123:Receptors, Interleukin; D053702:Receptors, Interleukin-11