Bronchial hyperresponsiveness changes after 5 months of regular procaterol inhalation therapy in asthmatic children.
It is well known that procaterol has more potent antiallergic properties than previous beta-stimulants. Thirteen children with asthma who could be controlled for 2 months with a regular procaterol aerosol given 4 times/day (10 micrograms/dose) were studied. Histamine challenges were performed before and an average of 5 months after the consecutive treatment. No significant differences were seen in peak expiratory flow values. PC20 increased significantly from 132.9 +/- 127.7 micrograms/ml to 762.4 +/- 1205.7 micrograms/ml after 5 months. These results suggest that asthmatic children who can be controlled with regular use of the beta-stimulant procaterol are likely to have a decreased bronchial hyperresponsiveness.
Kishida
M
M
Second Department of Pediatrics, Toho University School of Medicine, Japan.
Sasamoto
A
A
Saito
S
S
Aoki
T
T
Iikura
Y
Y
D000280:Administration, Inhalation; D000293:Adolescent; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006632:Histamine; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D017265:Procaterol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000336:Aerosols; D006632:Histamine; D017265:Procaterol