title: Time series analysis of intervention effects. Fluoxetine therapy as a case illustration.
abstract: This paper illustrates the advantages of time series analysis in documenting treatment effects through a case study of a trial of fluoxetine in a borderline woman being treated in a long-term inpatient unit for severe personality disorders. Data consisted of weekly self-reports of symptomatology over 58 weeks of hospitalization. Intervention analysis carried out after the patient was discharged documented the effectiveness of the medication and the differential timing of response in individual symptoms.
authors.affiliation: New York Hospital-Cornell Medical Center, Westchester Division, White Plains 10605.
authors.forename: J W
authors.initials: JW
authors.lastname: Hull
authors.forename: J F
authors.initials: JF
authors.lastname: Clarkin
authors.forename: G S
authors.initials: GS
authors.lastname: Alexopoulos
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006760:Hospitalization; D006801:Humans; D008962:Models, Theoretical; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine