title: [Hypersalivation as a leading symptom of neoplastic meningiosis in highly malignant non-Hodgkin's lymphoma].
abstract: Partial remission of a centroblastic non-Hodgkin's lymphoma, clinical stage IV A, in a 79-year-old man was achieved by six courses of chemotherapy with epirubicin, cyclophosphamide and vincristine. The only residual finding was a palpable small cervical lymphoma. After a treatment pause of about 6 weeks increasing hypersalivation set in which ultimately made food intake impossible and led to a breakdown in the patient's general state. Findings in the region of the head, neck, throat and the base of the skull were unremarkable, but cerebrospinal fluid contained 1300/3 cells, almost all of them lymphoblasts. After five intrathecal injections of at first 15 mg methotrexate and 4 mg dexamethasone each, followed by five more with 40 mg cytarabine added to them, the CSF cell count became normal. At the same time salivation clearly decreased and food intake became once again possible. The patient died 5 months later from hypercalcaemia due to osseous infiltrations. Until his death there was no recurrence of the hypersalivation as the cardinal sign of meningeal carcinomatosis.
authors.affiliation: Medizinische Klinik III, Städtischen Krankenhauses Leverkusen.
authors.forename: A
authors.initials: A
authors.lastname: Heider
authors.forename: B
authors.initials: B
authors.lastname: Engels
authors.forename: U
authors.initials: U
authors.lastname: Hartmann-Klosterkötter
authors.forename: M
authors.initials: M
authors.lastname: Kress
authors.forename: N
authors.initials: N
authors.lastname: Niederle
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000166:cytology; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D006801:Humans; D007278:Injections, Spinal; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications* / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage; D012798:Sialorrhea / Q000209:etiology*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003561:Cytarabine; D015251:Epirubicin; D014750:Vincristine; D003907:Dexamethasone; D003520:Cyclophosphamide; D008727:Methotrexate