Eosinophilia-myalgia syndrome: a clinicopathological study of four patients.
Eosinophilia-myalgia syndrome is an idiopathic disorder characterized by myalgia, especially of the extremities and peripheral eosinophilia. It is found in some patients as a result of tryptophan ingestion. We examined four patients showing clinical features and muscle biopsy changes consistent with eosinophilia-myalgia syndrome. The results of conventional histology were compared with immunohistochemical studies using monoclonal antibodies to human T lymphocytes, macrophages, HLA-DR antigen. Our findings confirm the potential importance of lymphocytes and macrophages in this syndrome. In particular, new observations are presented concerning the immunoreactivity of HLA-DR antigen.
Villanova
M
M
Laboratory of Neuropathology, University of Antwerp, Belgium.
De Clerck
L S
LS
Cras
P
P
Ceuterick
C
C
Van Marck
E
E
Guazzi
G C
GC
Martin
J J
JJ
D000328:Adult; D000911:Antibodies, Monoclonal; D001706:Biopsy; D016603:Eosinophilia-Myalgia Syndrome / Q000473:pathology*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens