title: Compensation between sympathetic nerves and adrenal medullary activity:effects of adrenodemedullation and chemical sympathectomy on catecholamine turnover.
abstract: To clarify functional compensation between the sympathetic nerves and the adrenal medulla, the effects of adrenodemedullation and chemical sympathectomy on norepinephrine (NE) turnover in some sympathetically innervated tissues and on NE and epinephrine (E) turnover in the adrenal gland were studied in rats. The rate of NE turnover was significantly accelerated by bilateral adrenodemedullation in the pancreas and in interscapular brown adipose tissue (IBAT). Chemical sympathectomy accelerated E turnover in the adrenal gland. These data indicate that some adrenergic nerves show functional compensation under conditions of depression of the adrenal medulla, and that compensatory acceleration of the adrenal medullary function occurs under conditions of adrenergic dysfunction.
authors.affiliation: Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ikarashi
authors.forename: H
authors.initials: H
authors.lastname: Ishimaru
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D002001:Adipose Tissue, Brown / Q000294:innervation / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism; D000313:Adrenal Medulla / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D004837:Epinephrine / Q000378:metabolism*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D016627:Oxidopamine; D010179:Pancreas / Q000294:innervation / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*; D019805:alpha-Methyltyrosine
chemical_list: D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D016627:Oxidopamine; D009638:Norepinephrine; D004837:Epinephrine