title: Antineuronal (anti-Ri) antibodies in a patient with steroid-responsive opsoclonus-myoclonus.
abstract: A 45-year-old woman developed opsoclonus, myoclonus, and severe truncal and gait ataxia. Serum and CSF contained IgG antibodies that appear to be identical to "anti-Ri" antibodies associated with paraneoplastic opsoclonus and ataxia. The patient had a fluctuating course with exacerbations that responded well to corticosteroids and later to cyclophosphamide. Her anti-Ri antibody titer has declined significantly but still remains high. After more than 3 years of follow-up, no neoplasm has been detected.
authors.affiliation: Department of Neurology, University of Alabama, Birmingham.
authors.forename: E J
authors.initials: EJ
authors.lastname: Dropcho
authors.forename: L B
authors.initials: LB
authors.lastname: Kline
authors.forename: J
authors.initials: J
authors.lastname: Riser
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D001259:Ataxia; D003520:Cyclophosphamide / Q000627:therapeutic use; D004172:Diplopia / Q000209:etiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged; D009207:Myoclonus / Q000188:drug therapy* / Q000276:immunology*; D013577:Syndrome
chemical_list: D000305:Adrenal Cortex Hormones; D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D003520:Cyclophosphamide