title: [Clinical analysis of ofloxacin in treatment of postinfectious exacerbations of endogenous bronchial asthma].
abstract: The aim of the study was to analyse the clinical effectiveness of ofloxacin in treatment of post-infectious exacerbations of endogenous bronchial asthma. Twenty eight patients (20 males, 8 females) were assessed. The following parameters were evaluated: bacteriological examination of the sputum (before and after treatment), morphological analysis of peripheral blood, bronchoalveolar lavage (performed in 11 patients). Additionally in 7 patients lymphocyte subpopulations of the peripheral blood were determined (OKT4/OKT8). Diurnal variations of serum levels of theophylline were assessed in 12 patients. The authors observed a clinical improvement in 26 patients. Following treatment the white cell blood count (WBC) and the CD4/CD8 ratio decreased. The same observations were made analysing the BAL differential count, in which a marked decrease of neutrophils was seen. The authors conclude that ofloxacin is a safe and efficient antimicrobial agent.
authors.affiliation: II Kliniki Chorób Wewnetrznych.
authors.forename: A
authors.initials: A
authors.lastname: Frank-Piskorska
authors.forename: T
authors.initials: T
authors.lastname: Płusa
authors.forename: E
authors.initials: E
authors.lastname: Józefczak
authors.forename: M
authors.initials: M
authors.lastname: Kałczak
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D013183:Sputum / Q000382:microbiology
chemical_list: D015242:Ofloxacin