title: Inhibition of lipid peroxidation in rat brain by nifedipine and clorazepate after electrically induced seizures.
abstract: The effect of nifedipine and clorazepate on the concentration of lipid peroxides (LP) in rat brain, and the characteristics of electrically induced seizures were assessed. A significant increase in the concentration of brain LP after electroshock was found. Both nifedipine (1.00 mg/kg per os) and clorazepate (20 mg/kg intraperitoneally) decreased the levels of LP in the rat brain after electroshock. Nifedipine combined with clorazepate brought an inhibition of LP formation and an additive anticonvulsant activity.
authors.affiliation: Department of Neurology, Medical Academy, Białystok, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Kułak
authors.forename: W
authors.initials: W
authors.lastname: Sobaniec
authors.forename: M
authors.initials: M
authors.lastname: Sobaniec-Lotowska
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003009:Clorazepate Dipotassium / Q000494:pharmacology*; D004597:Electroshock; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000378:metabolism*
chemical_list: D003009:Clorazepate Dipotassium; D009543:Nifedipine