Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10. The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands. The map position of lyt-10, inferred from its isolation from a t(10;14)(q24;q32) translocation, has been confirmed. NF-kappa Bp65 has now been mapped to 11q13, a site of frequent involvement in aberration in multiple tumor types.
Mathew
S
S
Laboratory of Cancer Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Murty
V V
VV
Dalla-Favera
R
R
Chaganti
R S
RS
D002874:Chromosome Mapping; D005453:Fluorescence; D017403:In Situ Hybridization; D016328:NF-kappa B / Q000235:genetics*; D052003:NF-kappa B p52 Subunit; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020569:Proto-Oncogene Proteins c-rel; D014157:Transcription Factors / Q000235:genetics*
D016328:NF-kappa B; D052003:NF-kappa B p52 Subunit; D011518:Proto-Oncogene Proteins; D020569:Proto-Oncogene Proteins c-rel; D014157:Transcription Factors