title: Application of carbon-11 labelled nicotine in the measurement of human cerebral blood flow and other physiological parameters.
abstract: Using positron emission tomography (PET), we measured the regional cerebral blood flow (rCBF) in five normal human subjects after intravenous injection of carbon-11 labeled (R)nicotine. The rCBF of the same subjects was measured by PET using the C15O2 inhalation steady-state method. The distribution of 11C activity in the brain after injection of 11C-(R)nicotine was almost equivalent to the CBF image obtained with the C15O2 inhalation stead-state method. The kinetics of 11C-(R)nicotine in the brain was analysed using a two-compartment model consisting of vascular and brain tissue compartments. The rCBF values obtained with 11C-(R)nicotine were higher than with C15O2 gas. The relatively long fixed distribution of 11C-(R)nicotine with a short uptake period allows stimulation studies by measurement of CBF to be performed with better photon flux and a longer imaging time than are possible with H215O.
authors.affiliation: Department of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yokoi
authors.forename: T
authors.initials: T
authors.lastname: Komiyama
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Lio
authors.forename: T
authors.initials: T
authors.lastname: Hara
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D009538:Nicotine