title: Mn-DPDP in MR imaging of pancreatic adenocarcinoma: initial clinical experience.
abstract: Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP) was tested as a contrast agent for magnetic resonance imaging of pancreatic adenocarcinoma in 15 patients. At enhanced T1-weighted spin-echo (SE) and enhanced T1-weighted gradient-echo (GRE) imaging, statistically significant increases in signal-to-noise ratio (S/N) for the pancreas (21% and 92%, respectively) and contrast-to-noise ratio (C/N) (91% and 209%, respectively) were found. The C/N at enhanced T1-weighted SE imaging was superior to that at unenhanced imaging, including T2-weighted SE imaging (P = .001). Subjective image analysis showed that delineation of the pancreas and pancreatic tumors was clearly improved (P = .05) on enhanced T1-weighted SE and GRE images compared with on unenhanced T1- and T2-weighted images. The liver enhanced 19% at T1-weighted SE imaging and 90% at T1-weighted GRE imaging. There was a significantly higher S/N increase in hepatic parenchyma than in pancreatic tissue at enhanced T1-weighted GRE imaging (P = .0026) but not at enhanced T1-weighted SE imaging.
authors.affiliation: Department of Diagnostic Radiology, Technical University of Aachen, Germany.
authors.forename: H B
authors.initials: HB
authors.lastname: Gehl
authors.forename: R
authors.initials: R
authors.lastname: Urhahn
authors.forename: K
authors.initials: K
authors.lastname: Bohndorf
authors.forename: P
authors.initials: P
authors.lastname: Klever
authors.forename: S
authors.initials: S
authors.lastname: Hauptmann
authors.forename: K P
authors.initials: KP
authors.lastname: Lodemann
authors.forename: S
authors.initials: S
authors.lastname: Matern
authors.forename: V
authors.initials: V
authors.lastname: Schumpelick
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008345:Manganese; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid