Increase of Parkinson disability after fluoxetine medication.
Depression is a major clinical feature of Parkinson's disease. We report the increased amount of motor disability in four patients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibility of a clinically relevant dopamine-antagonistic capacity of fluoxetine in Parkinson's disease patients must be considered.
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Movement Disorder Unit, Hospital Medisch Spectrum Twente, Enschede, Holland.
D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*
D005473:Fluoxetine