title: Birdshot chorioretinopathy and Lyme borreliosis.
abstract: Two patients in whom ocular Lyme disease was suspected and who had antibodies to Borrelia burgdorferi developed birdshot chorioretinopathy and carried the HLA-A29 antigen. In a series of 11 patients with birdshot chorioretinopathy who carried the HLA-A29 antigen, three patients had antibodies against B. burgdorferi as determined by either immunofluorescence assay, enzyme-linked immunosorbent assay, Western blot analysis, or a combination of these tests. Further studies will be necessary to evaluate whether this is a false-positive reaction or whether B. burgdorferi has a causative role in the pathogenesis of birdshot chorioretinopathy.
authors.affiliation: Netherlands Ophthalmic Research Institute, Amsterdam.
authors.forename: M S
authors.initials: MS
authors.lastname: Suttorp-Schulten
authors.forename: L
authors.initials: L
authors.lastname: Luyendijk
authors.forename: A P
authors.initials: AP
authors.lastname: van Dam
authors.forename: R J
authors.initials: RJ
authors.lastname: de Keizer
authors.forename: G S
authors.initials: GS
authors.lastname: Baarsma
authors.forename: P J
authors.initials: PJ
authors.lastname: Bos
authors.forename: A
authors.initials: A
authors.lastname: Rothova
mesh_terms: D015153:Blotting, Western; D015748:Borrelia burgdorferi Group / Q000302:isolation & purification; D002825:Chorioretinitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D005451:Fluorescein Angiography; D005455:Fluorescent Antibody Technique; D015234:HLA-A Antigens / Q000032:analysis; D006801:Humans; D008193:Lyme Disease / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D011859:Radiography; D014792:Visual Acuity
chemical_list: D015234:HLA-A Antigens; C035524:HLA-A29 antigen