[Anti-inflammatory activity of aqua-(aryloxyacetate) copper complexes].
The anti-inflammatory activity of selected mononuclear Aqua(aryloxyacetato)copper(II) complexes with the composition [Cu(R-O-CH2COO)2(H2O)n].mH2O (R = phenyl, n = 3; m = 0), 4-chlorophenyl (2; 0), 4-chloro-2-methylphenyl (2; 0) and naphthyl (2; 2) was examined using rat paw dextrano edema. The antiphlogistic effects of the tested complexes were compared to those for corresponding aryloxyacetic acids and salicylic acid and its Cu(II) salt. The compounds were administered i.p. in a single effective dose of 10 mg/kg. The complexes with R = phenyl, 4-chlorophenyl and 4-chloro-2-methylphenyl exhibited a biological activity comparable to that of copper(II) salicylate tetrahydrate.
Sokolík
J
J
Katedra chemickej teórie lieciv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Sedlácková
S
S
Racanská
E
E
Blahová
M
M
Svec
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000633:toxicity; D007093:Imidazoles / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry / Q000633:toxicity; D011720:Pyrazoles / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D009942:Organometallic Compounds; D011720:Pyrazoles