Rat liver pathomorphology during prolonged sodium valproate administration.
Prolonged administration (1, 3, 6, 9 and 12 months) to rats of an antiepileptic drug--sodium valproate (Vupral--"Polfa") in the dose of 200 mg/kg/day produced the first hepatic morphological lesions after 3 months of the experiment. These structural abnormalities progressively increased to achieve their peak within 12 months. The most prominent microscopic changes consisted of extensive microvesicular fatty change and vacuolar degeneration of periportal hepatocytes. Intralobular focal necrosis, infiltrations of lymphocytes, plasma cells, and phagocytes in the portal tracts, and centrilobular congestion were also present. The connective tissue did not proliferate either in periportal lobular zone or around the central veins. The described lesions seem thus to be reversible.
Sobaniec-Lotowska
M
M
Department of Pathological Anatomy, Medical Academy, Białystok, Poland.
Sobaniec
W
W
Kułak
W
W
D000818:Animals; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014635:Valproic Acid / Q000633:toxicity*
D014635:Valproic Acid