ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.
Moser
A R
AR
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
Mattes
E M
EM
Dove
W F
WF
Lindstrom
M J
MJ
Haag
J D
JD
Gould
M N
MN
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000818:Animals; D003433:Crosses, Genetic; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D006965:Hyperplasia; D008297:Male; D008321:Mammary Glands, Animal / Q000473:pathology*; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000473:pathology; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics / Q000473:pathology; D008679:Metaplasia; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D017354:Point Mutation
D015127:9,10-Dimethyl-1,2-benzanthracene; D005038:Ethylnitrosourea