title: [Acquired benign myofibroma of the skin (adult myofibroma)].
abstract: Adult myofibroma is an acquired skin tumour that is histologically identical to infantile myofibroma. Histologically, four tumour variants can be distinguished: leiomyoma type, cellular spindle cell type, haemangiopericytoma or glomus type, and biphasic type. Practical help in diagnosis is supplied by the hamartomatous composition of the leiomyoma-type, hyalinized spindle cell whorls, endothelium-lined haemangiopericytoma-like vascular channels, and desmin-negative, muscle-actin-positive myofibroblasts, which may show spindle cell or undifferentiated mesenchymal cell differentiation. The tumours clinically present as firm, occasionally bluish cutaneous or subcutaneous nodules. Adult myofibroma should be recognized as a distinct benign neoplasm, most probably of vascular origin. Clinicians and dermatopathologists must be aware that lesions identical to those of infantile myofibroma can occur in adults.
authors.affiliation: Dermatologische Gemeinschaftspraxis, Friedrichshafen.
authors.forename: H
authors.initials: H
authors.lastname: Kutzner
authors.forename: H
authors.initials: H
authors.lastname: Hügel
authors.forename: A
authors.initials: A
authors.lastname: Rütten
authors.forename: M
authors.initials: M
authors.lastname: Braun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000145:classification / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018224:Myofibromatosis / Q000145:classification / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000145:classification / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor