title: High incidence of Epstein-Barr virus detection in Hodgkin's disease and absence of detection in anaplastic large-cell lymphoma in children.
abstract: By in situ hybridization with EBER oligonucleotides and immunohistochemistry with anti-latent membrane protein 1 (LMP1) antibody, we compared the detection rate of Epstein-Barr virus (EBV) in Hodgkin's disease and anaplastic large-cell lymphomas in children. Among the 13 cases of Hodgkin's disease tested, 7 (54%) were found to be EBV associated (EBER transcripts +, LMP1 +). None of the 11 cases of ALC lymphomas was found to contain EBV genomes or gene products. This may indicate that EBV is not a pathogenic agent in anaplastic large-cell lymphomas in children in comparison to Hodgkin's disease.
authors.affiliation: Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire de Purpan, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Brousset
authors.forename: P
authors.initials: P
authors.lastname: Rochaix
authors.forename: S
authors.initials: S
authors.lastname: Chittal
authors.forename: H
authors.initials: H
authors.lastname: Rubie
authors.forename: A
authors.initials: A
authors.lastname: Robert
authors.forename: G
authors.initials: G
authors.lastname: Delsol
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016403:Lymphoma, Large B-Cell, Diffuse / Q000382:microbiology* / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology*