title: The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth.
abstract: The gingival health of 32 renal transplant patients who were medicated with cyclosporin was compared with a similar cohort of 23 renal transplant patients medicated with both cyclosporin and nifedipine. Both groups of patients had been taking the above medication for at least 3 months. Plaque scores, gingival inflammation and probing depths were similar for both groups. Patients medicated with the combination of nifedipine and cyclosporin had a significantly higher gingival overgrowth score (p = 0.046) when compared with the group receiving cyclosporin alone. The incidence of clinically significant overgrowth (i.e., overgrowth > 30% which would require surgical intervention) was similar in both groups. Gingival overgrowth was not related to cyclosporin dosage. It is concluded that patients taking cyclosporin or cyclosporin and nifedipine experience gingival overgrowth and that the severity of the overgrowth is greater in patients taking the combined therapy. The levels of plaque and gingival inflammation appear to be associated with this phenomenon.
authors.affiliation: Department of Prosthodontics, University of Newcastle upon Tyne, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Thomason
authors.forename: R A
authors.initials: RA
authors.lastname: Seymour
authors.forename: N
authors.initials: N
authors.lastname: Rice
mesh_terms: D000328:Adult; D015331:Cohort Studies; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D003774:Dental Plaque Index; D004338:Drug Combinations; D005260:Female; D005884:Gingival Hemorrhage / Q000139:chemically induced / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects*; D009910:Oral Hygiene; D010512:Periodontal Index; D015995:Prevalence
chemical_list: D004338:Drug Combinations; D016572:Cyclosporine; D009543:Nifedipine