title: Protection of vaccinia-primed macaques against SIVmne infection by combination immunization with recombinant vaccinia virus and SIVmne gp160.
abstract: Two Macaca fascicularis with preexisting immunity to vaccinia virus were immunized twice with recombinant vaccinia virus expressing SIVmne gp160. Their SIV-specific antibody responses were lower than that of vaccinia-naive animals immunized similarly. Upon repeated boosting with gp160, the SIV-specific antibody titers in vaccinia-primed animals reached similar levels as vaccinia-naive animals and with comparable neutralizing titers. Both animals were protected against repeated intravenous challenge with low-dose SIVmne E11S. These results are significant because SIVmne E11S infection in M. fascicularis is pathogenic and leads to AIDS-like diseases.
authors.affiliation: Bristol-Myers Squibb, Pharmaceutical Research Institute, Seattle, WA 98121.
authors.forename: S L
authors.initials: SL
authors.lastname: Hu
authors.forename: V
authors.initials: V
authors.lastname: Stallard
authors.forename: K
authors.initials: K
authors.lastname: Abrams
authors.forename: G N
authors.initials: GN
authors.lastname: Barber
authors.forename: L
authors.initials: L
authors.lastname: Kuller
authors.forename: A J
authors.initials: AJ
authors.lastname: Langlois
authors.forename: W R
authors.initials: WR
authors.lastname: Morton
authors.forename: R E
authors.initials: RE
authors.lastname: Benveniste
mesh_terms: D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D015686:Gene Products, env / Q000235:genetics / Q000276:immunology*; D007114:Immunization; D007117:Immunization, Secondary; D008252:Macaca fascicularis; D008969:Molecular Sequence Data; D016097:Simian Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000494:pharmacology; D014616:Vaccinia virus / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004279:DNA, Viral; D015686:Gene Products, env; D014614:Vaccines, Synthetic; D014765:Viral Vaccines