[The effect of alcohol on portal vein hemodynamics in nutritional-toxic liver cirrhosis].
The influence of alcohol on portal vein haemodynamics was assessed prospectively in 30 patients (20 men, 10 women; mean age 54.3 [34-70] years) with nutritional-toxic cirrhosis of the liver (Child-Pugh stages A-C) and portal vein hypertension. During the period of observation hepatic vein occlusion pressure as an indirect measure of portal vein pressure was repeatedly determined. In addition, the size of oesophageal varices and the Child-Pugh stage were monitored. After complete alcohol abstinence of one year, portal vein pressure fell from 23.11 to 12.43 mm Hg (-46%, P < 0.001), the Child-Pugh score from 8.08 to 7.2 (-10.9%, not significant), and the size of oesophageal varices was reduced from grade 1.33 to grade 0.79 (-40%, P < 0.02). On resuming alcohol abuse, portal vein pressure increased by an average of 10 mm Hg (+60%, P < 0.001) to its previous level of 25 mm Hg. The portal vein pressure has thus proved to be a sensitive gauge of alcohol abstinence or abuse. Lasting, absolute alcohol abstinence is essential in nutritional-toxic liver cirrhosis.
Klein
C P
CP
Department Innere Medizin-Gastroenterologie, Heinz-Kalk-Krankenhaus, Bad Kissingen.
Kalk
J F
JF
Müting
D
D
Klein
C G
CG
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004932:Esophageal and Gastric Varices / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000187:drug effects* / Q000503:physiopathology; D011446:Prospective Studies; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology / Q000503:physiopathology
D000431:Ethanol