title: Complications of dental surgery in persons with HIV disease.
abstract: Post tooth extraction infective complications have occasionally been described in HIV-infected persons. However, there is little objective data as to the frequency of this and the need for antibiotic prophylaxis. Similarly the frequency of postextraction bleeding in patients infected with HIV, who may have thrombocytopenia, is unknown. In the present study the frequency of postextraction complications has been investigated in a group of 38 persons at stages 2 to 4 of HIV infection and 26 matched subjects from patients groups commonly at risk of HIV infection but not seropositive. During 40 clinical procedures in HIV-infected patients, 100 (range 1 to 23, median 1) teeth were extracted. Three episodes of delayed postextraction healing were recorded. During 30 procedures in the non-HIV-infected persons, 68 (range 1 to 5, median, 2) teeth were extracted, and two episodes of delayed postextraction healing were recorded. These differences were not significant. Only one HIV-infected patient had an episode of severe postextraction bleeding: this was a hemophiliac who bled despite receiving factor VIII prophylaxis. The bleeding occurred 7 days after the extraction and ceased with tranexamic acid and additional factor VIII. No control subject had severe postextraction hemorrhage. It is concluded that postextraction complications are uncommon in HIV-infected patients and that routine antibiotic prophylaxis is not indicated.
authors.affiliation: Centre for the Study of Oral Disease, University of Bristol Dental Hospital and School, England.
authors.forename: S R
authors.initials: SR
authors.lastname: Porter
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: J
authors.initials: J
authors.lastname: Luker
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003730:Dental Care for Persons with Disabilities; D004368:Dry Socket / Q000209:etiology / Q000517:prevention & control; D005260:Female; D015658:HIV Infections; D006801:Humans; D008297:Male; D006472:Oral Hemorrhage / Q000209:etiology; D011292:Premedication; D013530:Surgical Wound Infection / Q000209:etiology / Q000517:prevention & control; D014081:Tooth Extraction / Q000009:adverse effects*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents