Localization of the human oncostatin M gene (OSM) to chromosome 22q12, distal to the Ewing's sarcoma breakpoint.
Using fluorescence in situ hybridization, a cosmid clone containing the gene for oncostatin M (OSM) was mapped to human chromosome 22q12, placing the OSM gene in the same chromosome band as the leukemia-inhibitory factor gene (LIF). The location of the OSM gene was determined relative to the t(11;22)(q24;q12) of Ewing's sarcoma and found to be distal to the translocation breakpoint on chromosome 22. Analysis of physical distances by pulsed-field gel electrophoresis demonstrated further that the two genes lie within 500 kb of each other.
Giovannini
M
M
Molecular Genetics Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138-9216.
Selleri
L
L
Hermanson
G G
GG
Evans
G A
GA
D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D004277:DNA, Single-Stranded; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D053683:Oncostatin M; D010455:Peptides / Q000235:genetics*; D012512:Sarcoma, Ewing / Q000235:genetics*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
D004277:DNA, Single-Stranded; C508351:OSM protein, human; D010455:Peptides; D053683:Oncostatin M