title: Long-term implantation of gentamicin-polymethylmethacrylate antibiotic beads.
abstract: Fifty-two chronic osteomyelitis patients treated with gentamicin-polymethylmethacrylate (Septopal) antibiotic bead chains were observed retrospectively to explore the relationship between the duration of bead implantation and clinical results. Group A contained 35 asymptomatic patients who had elective bead removal based on protocol, surgeon's preference, and patient variables. Group B consisted of 17 patients who retained the antibiotic beads. The presence or absence of redness, abscess, drainage, pain, or swelling at the wound site was documented for clinical evaluation. Findings indicate that Septopal bead chain implants exhibit higher success (remission) rates with increasing length of duration without increasing the risk of complications.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, University of Louisville, KY 40292.
authors.forename: S L
authors.initials: SL
authors.lastname: Henry
authors.forename: G A
authors.initials: GA
authors.lastname: Hood
authors.forename: D
authors.initials: D
authors.lastname: Seligson
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008768:Methylmethacrylates / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005839:Gentamicins; D008768:Methylmethacrylates; C030159:gentamicin-polymethylmethacrylate bead