title: Physical mapping of DNA markers in the q13-q22 region of the human X chromosome.
abstract: DNA probe screening of somatic cell hybrids derived from females with X;autosome translocations has enabled us to define eight new breakpoints within the Xq13-q22 region. Together with other X-chromosome rearrangements that have been described earlier, these breakpoints subdivide the Xq21-q22 region into 20 intervals. Our panel refines the physical assignment of 40 probes in the Xq21-q22 segment. Thus, these X-chromosome rearrangements are useful tools for ordering X-linked markers and genes on the proximal long arm of the human X chromosome.
authors.affiliation: Laboratoire de Génétique Humaine, Centre Régional de transfusion Sanguine, Vandoeuvre-les-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Philippe
authors.forename: F P
authors.initials: FP
authors.lastname: Cremers
authors.forename: M
authors.initials: M
authors.lastname: Chery
authors.forename: I
authors.initials: I
authors.lastname: Bach
authors.forename: N
authors.initials: N
authors.lastname: Abbadi
authors.forename: H H
authors.initials: HH
authors.lastname: Ropers
authors.forename: S
authors.initials: S
authors.lastname: Gilgenkrantz
mesh_terms: D000568:Amenorrhea / Q000235:genetics; D000818:Animals; D002352:Carrier Proteins; D002874:Chromosome Mapping; D006224:Cricetinae; D005260:Female; D000080865:Formins; D005819:Genetic Markers; D006822:Hybrid Cells; D008607:Intellectual Disability / Q000235:genetics; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014178:Translocation, Genetic; D014960:X Chromosome / Q000648:ultrastructure
chemical_list: D002352:Carrier Proteins; C491462:DIAPH2 protein, human; D000080865:Formins; D005819:Genetic Markers