title: Localization of the human tripeptidyl peptidase II gene (TPP2) to 13q32-q33 by nonradioactive in situ hybridization and somatic cell hybrids.
abstract: We have assigned the human tripeptidyl peptidase II (TPP2) gene to chromosome region 13q32-q33 using two different methods. First, a full-length TPP2 cDNA was used as a probe on Southern blots of DNA from a panel of human/rodent somatic cell hybrids. The TPP2 sequences were found to segregate with the human chromosome 13. Second, fluorescence in situ hybridization analysis was performed with the same probe. This analysis supported the chromosome 13 localization and further refined it to region 13q32-q33.
authors.affiliation: Department of Clinical Genetics, East Hospital, University of Göteborg, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Martinsson
authors.forename: M
authors.initials: M
authors.lastname: Vujic
authors.forename: B
authors.initials: B
authors.lastname: Tomkinson
mesh_terms: D000626:Aminopeptidases; D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000032:analysis / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D015183:Restriction Mapping; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D004247:DNA; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases; D000626:Aminopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; C048001:tripeptidyl-peptidase 2; D012697:Serine Endopeptidases