Metabolism of [1-14C]linoleic acid in human promyelocytic leukemia HL-60 cells grown and differentiated in serum-free medium.
The metabolism of [1-14C]linoleic acid (LA) was studied in human promyelocytic leukemia cell line HL-60, grown and differentiated in serum-free medium. Both undifferentiated and dibutyryl cyclic AMP-differentiated HL-60 cells exhibited similar patterns of conversion of LA to four other major fatty acids (i.e. 18:3, 20:3, 20:4, and 22:4).
Baykousheva
S
S
Department of Biochemistry, Bulgarian Academy of Sciences, Sofia.
D002250:Carbon Radioisotopes; D002454:Cell Differentiation; D002455:Cell Division; D016895:Culture Media, Serum-Free; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000378:metabolism*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D002250:Carbon Radioisotopes; D016895:Culture Media, Serum-Free; D005227:Fatty Acids; D008041:Linoleic Acids; D019787:Linoleic Acid