title: [Antimicrobial activity of diazole-(N-salicylidene-L-alpha- alaninato)-copper complexes].
abstract: The antimicrobial activities of a group of copper(II) chelates with the composition [Cu(TSB)(L)] or [Cu(TSB)(L')]. (TSB = N-salicylidene-L-alpha-alaninate dianion, L = imidazole and its alkyl derivatives, L' = pyrazole and 3,5-dimethylpyrazole) were studied. Bis-diazole complexes with L' = pyrazole and 3,5-dimethylpyrazole were found to be the most active against S. aureus (MIC = 78 and 20 micrograms.cm-3), less effective against C. albicans (156 micrograms.cm-3), T. terrestre and M. gypseum (100 micrograms.cm-3). The observed biological properties of complexes are discussed in relation to their proposed structures.
authors.affiliation: Katedra chemickej teórie lieciv a Katedra biochémie a mikrobiológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
authors.forename: M
authors.initials: M
authors.lastname: Blahová
authors.forename: J
authors.initials: J
authors.lastname: Sokolík
authors.forename: S
authors.initials: S
authors.lastname: Sedlácková
authors.forename: E
authors.initials: E
authors.lastname: Burianová
authors.forename: D
authors.initials: D
authors.lastname: Mlynarcík
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000254:growth & development*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000254:growth & development*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents