Detection of serum cytokine levels in experimental cancer cachexia of colon 26 adenocarcinoma-bearing mice.
The aim of this study was to evaluate the correlations between tumor size and cachexia parameters including cytokine levels in serum. In transplantable colon 26 adenocarcinoma-bearing mice, parameters having negative correlations with tumor size were host weight changes, epididymal adipose tissue weight, glucose and interleukin 3 (IL-3) concentration in serum. Parameters having a positive correlation with tumor size were the number of circulating white blood cells and immunosuppressive acidic protein (IAP), interleukin 6 (IL-6) and transforming growth factor beta (TGF-beta) concentration in serum.
Tanaka
M
M
Pharmaceutical Research Laboratory, Sapporo Breweries Ltd., Shizuoka, Japan.
Miyazaki
H
H
Takeda
Y
Y
Takeo
S
S
D000230:Adenocarcinoma / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002100:Cachexia / Q000209:etiology / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D016207:Cytokines / Q000097:blood*; D007377:Interleukin-3 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D009363:Neoplasm Proteins / Q000097:blood; D016212:Transforming Growth Factor beta / Q000097:blood
D001786:Blood Glucose; D016207:Cytokines; D007377:Interleukin-3; D015850:Interleukin-6; D009363:Neoplasm Proteins; D016212:Transforming Growth Factor beta; C030193:immunosuppressive acidic protein