Naturally occurring deuterium is essential for the normal growth rate of cells.
The role of naturally occurring D in living organisms has been examined by using deuterium-depleted water (30-40 ppm D) instead of water containing the natural abundance of D (150 ppm). The deuterium-depleted water significantly decreased the growth rate of the L929 fibroblast cell line, and also inhibited the tumor growth in xenotransplanted mice. Eighty days after transplantation in 10 (59%) out of 17 tumorous mice the tumor, after having grown, regressed and then disappeared. We suggest that the naturally occurring D has a central role in signal transduction involved in cell cycle regulation.
Somlyai
G
G
HYD Ltd. for Research and Development, Budapest, Hungary.
Jancsó
G
G
Jákli
G
G
Vass
K
K
Barna
B
B
Lakics
V
V
Gaál
T
T
D000230:Adenocarcinoma; D000818:Animals; D001834:Body Water / Q000502:physiology; D001943:Breast Neoplasms; D002455:Cell Division / Q000502:physiology*; D002460:Cell Line; D016895:Culture Media, Serum-Free; D003903:Deuterium; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D016895:Culture Media, Serum-Free; D003903:Deuterium