dHMG-Z, a second HMG-1-related protein in Drosophila melanogaster.
We report the identification of dHMG-Z, a gene related to dHMG-D and encoding a second invertebrate homologue of HMG 1 protein. The encoded proteins is 65% identical to dHMG-D protein, and also contains a single HMG-box as the DNA recognition motif. Analogous to dHMG-D, two transcripts are observed for dHMG-Z which are differentially regulated, and are the product of zygotic transcription unlike the dHMG-D transcripts which arise from both maternal and zygotic transcription. The genes for dHMG-D and dHMG-Z are located on adjacent loci in the genome and each contains two introns. The position of the second intron in the coding region is conserved between the two genes suggesting a common origin via gene duplication.
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MRC Laboratory of Molecular Biology, Cambridge, UK.
Churchill
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Searles
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D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006609:High Mobility Group Proteins / Q000235:genetics*; D007814:Larva; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism
D006609:High Mobility Group Proteins; D012333:RNA, Messenger; D004247:DNA