title: Thrombus imaging with 99mTc-HMPAO-labeled platelets and 111In-labeled monoclonal antifibrin antibodies.
abstract: Eighteen patients with suspicion of deep venous thrombosis (DVT) in the lower extremities were imaged both with autologous 99mTc-HMPAO-labeled platelets (Tc-PLT) and 111In-labeled monoclonal antifibrin antibodies (In-MoAbs) on the same day. Presence or absence of thrombosis was verified by venography. Tc-PLT was given i.v. followed after 30 min by In-MoAbs. Anterior and posterior projections of the lower extremities were obtained with a large field-of-view gamma camera at 5 to 25 min, 2 h, 4 to 6 h, and 20 h after administration of the marker. Both Tc-PLT and In-MoAbs detected DVT well but less frequently than venography. Thrombi were visualized at 2 to 4 h after injection. The quality of images was better with Tc-PLT than with In-MoAbs. In the patients treated during the study, heparin significantly (p < 0.01) inhibited the uptake of Tc-PLT but not of In-MoAbs. We conclude that both Tc-PLT and In-MoAbs are suitable agents for the detection of DVT especially in patients without anticoagulation.
authors.affiliation: Department of Nuclear Medicine, Päijät-Häme Central Hospital, Lahti, Finland.
authors.forename: M S
authors.initials: MS
authors.lastname: Vorne
authors.forename: T T
authors.initials: TT
authors.lastname: Honkanen
authors.forename: T J
authors.initials: TJ
authors.lastname: Lantto
authors.forename: R O
authors.initials: RO
authors.lastname: Laitinen
authors.forename: K J
authors.initials: KJ
authors.lastname: Karppinen
authors.forename: S V
authors.initials: SV
authors.lastname: Jauhola
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D001792:Blood Platelets; D005260:Female; D005337:Fibrin / Q000276:immunology; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D010690:Phlebography; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D013924:Thrombophlebitis / Q000000981:diagnostic imaging*
chemical_list: D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D005337:Fibrin