Incidence of tubulostromal adenoma of the ovary in aged germ cell-deficient mice.
Female mice homozygous for the germ cell-deficient (gcd) mutation enter reproductive senescence prematurely due to a dearth of germ cells arising in embryonic development. The ovaries of young gcd/gcd animals are atrophic, composed of little more than stromal cells in a connective tissue matrix. By one year of age, 56 per cent of homozygotes have developed tubulostromal adenoma of the ovary while 100 per cent wild-type and heterozygous littermates are phenotypically normal. Since these animals develop ovarian tumours more frequently as a consequence of a single autosomal recessive mutation, they will be useful models for the study of ovarian neoplasia.
Duncan
M K
MK
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854.
Chada
K K
KK
D000236:Adenoma / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D000375:Aging / Q000473:pathology*; D000818:Animals; D001284:Atrophy / Q000473:pathology; D005260:Female; D005808:Genes, Recessive / Q000235:genetics; D006720:Homozygote; D015994:Incidence; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D010063:Ovum / Q000473:pathology*; D010641:Phenotype; D012376:Rodent Diseases / Q000453:epidemiology* / Q000235:genetics