title: Success of estrogen-progesterone therapy in long-standing bleeding gastrointestinal angiodysplasia. Report of a case.
abstract: Gastrointestinal angiodysplasia is a common cause of occult bleeding. Surgical and endoscopic treatments are often ineffective. Recently, estrogen-progesterone therapy proved to be effective in these patients. We describe herein an 84-year-old man who presented with prolonged gastrointestinal bleeding, in whom treatment with estrogen-progesterone stopped the bleeding. We suggest that hormonal therapy should be considered in cases of prolonged obscure gastrointestinal bleeding thought to be due to angiodysplasia. This therapy should be instituted intermittently for a prolonged period. The role of progesterone, especially in men, should be reconsidered.
authors.affiliation: Department of Gastroenterology, Sourasky Medical Center, Ichilov Hospital, Tel Aviv, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Moshkowitz
authors.forename: N
authors.initials: N
authors.lastname: Arber
authors.forename: N
authors.initials: N
authors.lastname: Amir
authors.forename: T
authors.initials: T
authors.lastname: Gilat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016888:Angiodysplasia / Q000150:complications*; D004064:Digestive System / Q000098:blood supply*; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000009:adverse effects / Q000627:therapeutic use*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D011374:Progesterone / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence
chemical_list: D004967:Estrogens; D011374:Progesterone