An experimental anti-idiotype vaccine mimicking lipopolysaccharide gives protection against Pasteurella multocida type A infection in mice.
An anti-idiotype strategy was employed which showed that polyclonal anti-idiotype antibodies could be produced which could mimic a linear Pasteurella multocida lipopolysaccharide (LPS) molecule. These antibodies when used as vaccine antigens, induced antibodies which recognised LPS and imparted acquired protection upon syngeneic vaccinates challenged with homologous organisms.
Sutherland
A D
AD
Hannah Research Institute, Ayr, UK.
Davies
R C
RC
Murray
J
J
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000276:immunology*; D007132:Immunoglobulin Isotypes / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010326:Pasteurella Infections / Q000517:prevention & control*; D016979:Pasteurella multocida / Q000276:immunology*; D014611:Vaccination
D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007132:Immunoglobulin Isotypes; D008070:Lipopolysaccharides