title: Antecedent clinical features associated with dementia in Parkinson's disease.
abstract: In a prospective cohort study, we examined clinical features in 250 nondemented patients with idiopathic Parkinson's disease (PD) and then evaluated their association with incident dementia during 5 years of follow-up. Seventy-four of the patients became demented. Odds ratios for incident dementia with PD were increased for the following: being older than 70 years of age (2.7; 1.4 to 5.5), having a PD rating scale score greater than 25 (3.0; 1.5 to 6.2), being depressed (2.7; 1.5 to 6.6), being confused or psychotic on levodopa (3.3; 1.3 to 8.7), or having facial masking as a presenting sign (6.1; 1.4 to 26.9).
authors.affiliation: Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: K
authors.initials: K
authors.lastname: Marder
authors.forename: M X
authors.initials: MX
authors.lastname: Tang
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
mesh_terms: D000368:Aged; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology; D003863:Depression / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D015995:Prevalence; D011605:Psychoses, Substance-Induced / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D007980:Levodopa