Early MRI findings in Creutzfeldt-Jakob disease.
We describe the MRI changes preceding the onset of myoclonus in two patients whose post-mortem examination confirmed the diagnosis of Creutzfeldt-Jakob disease (CJD). MRI showed changes in the striatum early in the course of CJD (2-6 months after the onset of apathy, interpreted as depression, and 1-2 months before the onset of further clinical symptoms). Only in one patient did electroencephalography record the typical triphasic sharp-waves, 1 month after MRI.
Onofrj
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Istituto di Neurologia, Università G. D'Annunzio, Chieti, Italy.
Fulgente
T
T
Gambi
D
D
Macchi
G
G
D001921:Brain / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009207:Myoclonus / Q000473:pathology; D013997:Time Factors