Indomethacin and disodium etidronate for the prevention of recurrence of heterotopic ossification after surgical resection. Two case reports.
Two spinal cord injured patients had extensive heterotopic ossifications around their hips surgically removed. The use of disodium etidronate from 2 weeks presurgery to 2-5 months postsurgery and in particular indomethacin 25 mg twice daily, from 2 weeks prior to surgery to 6 weeks postsurgery may have helped to prevent recurrence of the ossifications in the follow up periods of 4 and 5 years respectively.
Biering-Sørensen
F
F
Centre for Spinal Cord Injured, Department TH, Rigshospitalet, Copenghagen, Denmark.
Tøndevold
E
E
D000293:Adolescent; D000328:Adult; D012968:Etidronic Acid / Q000627:therapeutic use*; D006615:Hip / Q000601:surgery; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D009999:Ossification, Heterotopic / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery; D012008:Recurrence; D013119:Spinal Cord Injuries / Q000150:complications*
D012968:Etidronic Acid; D007213:Indomethacin