title: Effects of propranolol on gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy.
abstract: This study investigated the effects of the short-term administration of propranolol on gastric blood perfusion in cirrhotic patients with portal hypertensive gastropathy. Portal hypertensive gastropathy is a common cause of nonvariceal bleeding in cirrhosis, which is associated with increased gastric mucosal perfusion and is favorably influenced by propranolol therapy. Gastric mucosal perfusion was evaluated with laser-Doppler flowmetry and reflectance spectrophotometry. Measurements were performed under basal conditions and after the double-blind administration of propranolol (0.15 mg/kg intravenously) or placebo. Propranolol administration significantly reduced (p < 0.001) the laser-Doppler signal (2.93 +/- 0.23 vs. 2.25 +/- 0.22 V) and the hemoglobin content of the gastric mucosa (99.2 +/- 3.8 vs. 89.3 +/- 3.1 arbitrary units), whereas the oxygen content remained unchanged (37.4 +/- 1.2 vs. 36.9 +/- 1.0 arbitrary units). Placebo administration had no effect in any of these parameters. Changes in gastric perfusion after propranolol administration were associated with a significant decrease in hepatic venous pressure gradient and azygos blood flow. We conclude that short-term propranolol administration, in addition to lowering portal pressure, reduces the increased gastric blood perfusion in cirrhotic patients with portal hypertensive gastropathy, an effect that may contribute to prevention of bleeding from these lesions.
authors.affiliation: Gastroenterology Department Hosptial Clínic, Barcelona University, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Panés
authors.forename: J M
authors.initials: JM
authors.lastname: Bordas
authors.forename: J M
authors.initials: JM
authors.lastname: Piqué
authors.forename: J C
authors.initials: JC
authors.lastname: García-Pagán
authors.forename: F
authors.initials: F
authors.lastname: Feu
authors.forename: J
authors.initials: J
authors.lastname: Terés
authors.forename: J
authors.initials: J
authors.lastname: Bosch
authors.forename: J
authors.initials: J
authors.lastname: Rodés
mesh_terms: D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000503:physiopathology; D007275:Injections, Intravenous; D017078:Laser-Doppler Flowmetry; D008103:Liver Cirrhosis / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D011433:Propranolol / Q000494:pharmacology*; D012039:Regional Blood Flow; D013053:Spectrophotometry; D013152:Splanchnic Circulation / Q000187:drug effects; D013270:Stomach / Q000098:blood supply; D013272:Stomach Diseases / Q000209:etiology / Q000503:physiopathology*
chemical_list: D011433:Propranolol