title: Effect of patent ductus arteriosus on Doppler-derived right ventricular systolic time intervals.
abstract: Right ventricular systolic time intervals (RVSTI) and noninvasive Doppler-derived pulmonary blood flow were measured before and after surgical ductus ligation in 18 otherwise healthy infants and children who were older than 3 months of age. Right ventricular preejection period (PEP) and the ratio of preejection period and right ventricular ejection time (PEP/RVET), both corrected or uncorrected for heart rate, decreased significantly following surgery (PEP 71 +/- 14 vs. 50 +/- 13, p < 0.001 and PEP/RVET 0.29 +/- 0.06 vs. 0.21 +/- 0.05, p < 0.001). The volume of pulmonary blood flow correlated with PEP/RVET (r = 0.48, p = 0.003). The magnitude of the change in pulmonary blood flow correlated with the change in PEP/RVET (r divided by 0.56, p = 0.016). The velocity of circumferential fiber shortening (VCFc) increased after surgery, but not significantly. We speculate that patent ductus arteriosus has a similar effect on right ventricular performance when other congenital heart defects are present.
authors.affiliation: Division of Pediatric Cardiology, Oregon Health Sciences University, Portland 97201.
authors.forename: G M
authors.initials: GM
authors.lastname: Silberbach
authors.forename: R L
authors.initials: RL
authors.lastname: Imus
authors.forename: R W
authors.initials: RW
authors.lastname: McDonald
authors.forename: K
authors.initials: K
authors.lastname: Andrilenas
authors.forename: M J
authors.initials: MJ
authors.lastname: Rice
authors.forename: M D
authors.initials: MD
authors.lastname: Reller
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D013599:Systole / Q000502:physiology*; D013997:Time Factors; D016278:Ventricular Function, Right / Q000502:physiology*