Does exclusion of enteral lipid assist remission in Crohn's disease?
Based on the improvement of Crohn's disease (CD) with elemental diets, we treated a patient with recurrent stenosing disease using prednisolone and drastic reduction of oral lipid intake. Complete symptomatic and good radiological improvement took place. A newly proposed hypothesis for CD suggests that enteral lipids together with certain luminal bacterial fragments become strongly antigenic to produce an inflammatory reaction analogous to the adjuvant response. Because of the apparent success of dietary lipid exclusion in this patient, we suggest that it be considered as a future option for management of acute CD.
Roediger
W E
WE
Department of Surgery, Queen Elizabeth Hospital, Woodville, S. A., Australia.
Giles
A
A
Kaczmar
A
A
Ali
S
S
D000328:Adult; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000178:diet therapy*; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007082:Ileum / Q000000981:diagnostic imaging; D011239:Prednisolone / Q000008:administration & dosage; D011859:Radiography; D012074:Remission Induction; D013997:Time Factors
D004041:Dietary Fats; D011239:Prednisolone