Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.
Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.
Bergelson
J M
JM
Laboratory of Infectious Disease, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
St John
N
N
Kawaguchi
S
S
Chan
M
M
Stubdal
H
H
Modlin
J
J
Finberg
R W
RW
D000818:Animals; D000911:Antibodies, Monoclonal; D016466:CHO Cells; D006224:Cricetinae; D003588:Cytopathogenic Effect, Viral; D004457:Echovirus Infections / Q000382:microbiology*; D029822:Enterovirus B, Human / Q000254:growth & development*; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D016029:Receptors, Very Late Antigen / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D014162:Transfection
D000911:Antibodies, Monoclonal; D016029:Receptors, Very Late Antigen; D011991:Receptors, Virus