Effects of Brazilin on glucose oxidation, lipogenesis and therein involved enzymes in adipose tissues from diabetic KK-mice.
In order to address the hypoglycemic mechanism of brazilin, effects on glucose metabolism in epididymal adipose tissue from diabetic KK-mice were investigated. Brazilin remarkably lowered non fasting plasma glucose level without any changes in plasma insulin level. Brazilin significantly increased the rate of glucose oxidation and lipogenesis only in the presence of insulin. Activities of glucose-6 phosphate dehydrogenase and fatty acid synthetase, involved in glucose oxidation and lipogenesis respectively, were significantly increased. These results suggest that brazilin might exert hypoglycemic action in insulin resistance state by, at least in part, regulating the enzymatic reaction process involved in glucose metabolism.
Moon
C K
CK
College of Pharmacy, Seoul National University, Korea.
Lee
S H
SH
Lee
M O
MO
Kim
S G
SG
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction
D001578:Benzopyrans; D007004:Hypoglycemic Agents; D008055:Lipids; C044362:brazilin; D005947:Glucose