title: Interictal heart rate patterns in partial seizure disorders.
abstract: Epileptogenic mesial temporal damage may alter interictal autonomic patterning. Analysis of heart rate variability in 19 patients with complex partial seizures revealed cases of persistent, high-amplitude, 4 to 9 per minute fluctuations in heart rate during alert waking. This pattern was most pronounced in poor candidates for anterior temporal lobe resection (2/19). The 4 to 9 per minute heart-rate variability pattern may emerge following diffuse, extratemporal, or bilateral mesial temporal damage, which interferes with descending forebrain influences on cardiovascular regulation.
authors.affiliation: Department of Anatomy and Cell Biology, UCLA School of Medicine 90024-1763.
authors.forename: R C
authors.initials: RC
authors.lastname: Frysinger
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: R M
authors.initials: RM
authors.lastname: Harper
mesh_terms: D000293:Adolescent; D000328:Adult; D015716:Electrocardiography, Ambulatory; D004569:Electroencephalography; D017029:Epilepsy, Complex Partial / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D012016:Reference Values; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome