title: Postoperative decline in plasma aspirin-esterase and cholinesterase activity in surgical patients.
abstract: We studied preoperative and postoperative plasma hydrolysis of aspirin and plasma cholinesterase activity in surgical patients. Postoperative aspirin esterase and cholinesterase activities fell sharply (119 +/- 32 micrograms ml h-1 and 3746 +/- 1068 U l-1 respectively; P < 0.01) in comparison to basal preoperative values (157 +/- 33 micrograms ml h-1 and 4620 +/- 940 U l-1 respectively, P < 0.01). We suggest that alterations in plasma esterase during the postoperative period may be related to the metabolic response to anesthesia- and surgery-induced stress.
authors.affiliation: Clinical Pharmacology Unit, University of Granada Hospital, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Puche
authors.forename: E
authors.initials: E
authors.lastname: Gómez-Valverde
authors.forename: M
authors.initials: M
authors.lastname: García Morillas
authors.forename: F
authors.initials: F
authors.lastname: Jorde
authors.forename: F
authors.initials: F
authors.lastname: Fajardo
authors.forename: J M
authors.initials: JM
authors.lastname: García Gil
mesh_terms: D000328:Adult; D000368:Aged; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002763:Cholecystectomy; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D059685:Herniorrhaphy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013514:Surgical Procedures, Operative
chemical_list: D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase; D002802:Cholinesterases