Effect of four plant phenols, beta-carotene and alpha-tocopherol on 3(H)benzopyrene-DNA interaction in vitro in the presence of rat and mouse liver postmitochondrial fraction.
The modulatory effect of beta-carotene, alpha-tocopherol and the four plant phenols eugenol, hydroxychavicol, curcumin and catechin on mouse and rat liver postmitochondrial fraction (S9 mix)-mediated 3(H)benzopyrene (B(a)P)-DNA interaction in vitro was studied. All the plant phenolics significantly inhibited 3(H)B(a)P-DNA interaction in the presence of both mouse and rat liver S9 fractions. In contrast, alpha-tocopherol proved to be ineffective in the presence of both types of S9 mix, whereas beta-carotene inhibited only mouse S9 mix-mediated 3(H)B(a)P-DNA interaction.
Lahiri
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Swami Prakashanda Ayurveda Research Centre, Juhu, Bombay, India.
Bhide
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001580:Benzopyrenes / Q000494:pharmacology*; D001711:Biotransformation; D002338:Carotenoids / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology; D004247:DNA / Q000187:drug effects*; D005054:Eugenol / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008930:Mitochondria, Liver / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013347:Subcellular Fractions / Q000187:drug effects; D014810:Vitamin E / Q000494:pharmacology*; D019207:beta Carotene
D016588:Anticarcinogenic Agents; D001580:Benzopyrenes; D010636:Phenols; D010936:Plant Extracts; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D005054:Eugenol; D002392:Catechin; D004247:DNA; D003474:Curcumin