title: Cerebral monitoring during cardiopulmonary bypass in children.
abstract: Although cerebral monitoring during CPB remains primarily investigational, recent data support its clinical utility. In particular, it is cerebral metabolic monitoring that provides meaningful information in terms of preparing the brain for dhCPB and dhCA. Cerebral blood flow or cerebral blood flow velocity monitoring is less beneficial due to the presence of luxuriant cerebral blood flow at deep hypothermic temperatures. Conventional temperature monitoring can be improved upon by adding jugular venous oxygen saturation monitoring to satisfy the primary goal of cerebral protection--uniform cerebral cooling and metabolic suppression. Although online measures of cerebral cellular metabolism are not widely available, early experience with near infrared technology suggests that it is a feasible and reliable monitor of cerebral metabolic activity and is likely to represent an important noninvasive continuous monitor in the near future. CMRO2 recovery data have suggested that cerebral metabolic suppression is more severe the longer the period of dhCA. Cerebral protection strategies, such as intermittent cerebral perfusion have demonstrated less metabolic suppression of dhCA in animal models and are currently undergoing clinical evaluation in our institution. Finally, the postoperative period remains a high-risk period for neurologic injury because temperatures are normothermic, cardiac output is reduced, cerebral autoregulation is impaired, and management strategies, such as hyperventilation, are commonly used to increase pulmonary blood flow with little knowledge on its effects on cerebral perfusion.
authors.affiliation: Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710.
authors.forename: F H
authors.initials: FH
authors.lastname: Kern
authors.forename: R M
authors.initials: RM
authors.lastname: Schell
authors.forename: W J
authors.initials: WJ
authors.lastname: Greeley
mesh_terms: D001921:Brain / Q000502:physiology*; D002315:Cardiopulmonary Bypass; D002648:Child; D006801:Humans; D008991:Monitoring, Physiologic