title: A method for stabilising technetium-99m exametazime prepared from a commercial kit.
abstract: Technetium-99m exametazime (99mTc-d,l-HMPAO), prepared by the reconstitution of the Ceretec kit, is widely used in the investigation of regional cerebral blood flow. The radiochemical purity specification of not less than 80% lipophilic complex requires that the kit is used within 30 min of reconstitution. In certain circumstances this imposes restrictions on its clinical availability. A number of approaches to extending the 30-min shelf life have been proposed and these are discussed. A method of stabilising the kit by the addition of 200 micrograms cobalt chloride hexahydrate (CoCl2 x 6H2O) in 2 ml of water is described. The addition of this solution can extend the shelf life of the reconstituted kit to at least 5 h post reconstitution.
authors.affiliation: Pharmaceuticals Research and Development, Amersham International plc, Buckinghamshire, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Weisner
authors.forename: G R
authors.initials: GR
authors.lastname: Bower
authors.forename: L A
authors.initials: LA
authors.lastname: Dollimore
authors.forename: A M
authors.initials: AM
authors.lastname: Forster
authors.forename: B
authors.initials: B
authors.lastname: Higley
authors.forename: A E
authors.initials: AE
authors.lastname: Storey
mesh_terms: D004355:Drug Stability; D006801:Humans; D015609:Organotechnetium Compounds; D010091:Oximes; D011933:Reagent Kits, Diagnostic; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D011933:Reagent Kits, Diagnostic; D019690:Technetium Tc 99m Exametazime