Improvement in glucose tolerance of insulin resistant rats after chronic or acute administration of benfluorex.
The effects of Benfluorex administration on glucose tolerance have been examined in young and old Sprague Dawley rats. The ageing rats were used as a model of insulin resistance. Chronic oral administration of Benfluorex decreased triglycerides levels and normalized glucose tolerance in ageing rats, independently of effects on body weight. Acute intraportal administration of 0.45 mg/kg/h of Benfluorex for 30 min resulted in a 50% increase in glucose tolerance in old rats, but did not modify that in young rats. The improved glucose tolerance brought about by Benfluorex in an animal model of insulin resistance may suggest a wider therapeutic application in man, to include insulin resistant states as type II diabetes or Syndrome X.
Lacour
F
F
Division of Metabolic Diseases, Institut de Recherches SERVIER, Suresnes, France.
Espinal
J
J
Arnaud
O
O
Duhault
J
J
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D004334:Drug Administration Schedule; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018149:Glucose Intolerance / Q000188:drug therapy*; D005951:Glucose Tolerance Test; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D001786:Blood Glucose; D000960:Hypolipidemic Agents; D005277:Fenfluramine; C001584:benfluorex