title: Giant gastric ulcers: an unusual manifestation of Crohn's disease.
abstract: We report a patient with Crohn's disease manifesting as recurrent giant gastric ulcers, with subsequent perforation and gastric outlet obstruction. The ulcers contained granulomas, and the patient was achlorhydric. To our knowledge, this is the first report of giant ulcers in a patient with gastric Crohn's disease. This case demonstrates another gastric manifestation of Crohn's disease, it documents nonmalignant gastric ulcers in the setting of achlorhydria, and it raises the possibility of Crohn's disease in the differential diagnosis of giant gastric ulcers refractory to medical management.
authors.affiliation: Department of Medicine, University of Pennsylvania Medical Center, Philadelphia.
authors.forename: D
authors.initials: D
authors.lastname: Moonka
authors.forename: G R
authors.initials: GR
authors.lastname: Lichtenstein
authors.forename: M S
authors.initials: MS
authors.lastname: Levine
authors.forename: J L
authors.initials: JL
authors.lastname: Rombeau
authors.forename: E E
authors.initials: EE
authors.lastname: Furth
authors.forename: R P
authors.initials: RP
authors.lastname: MacDermott
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D017219:Gastric Outlet Obstruction / Q000209:etiology; D006801:Humans; D008297:Male; D010439:Peptic Ulcer Perforation / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D012008:Recurrence; D013276:Stomach Ulcer / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*