Growth factor second messenger systems: oncogenes and the heterotrimeric GTP-binding protein connection.
We feel that there is now compelling evidence that the GTP-binding proteins play more than just a coordinating role in the actions of both tyrosine kinase and nontyrosine kinase receptor signal transduction. These similarities appear to represent just a small component of the convergence in the signaling pathways for structurally dissimilar receptor subsets. Future years will see further understanding of the intricacies of these G-protein-proto-oncogene interactions, and the extension into the potential role in growth factor action played by the expanding number of known members of this G-protein family.
Crouch
M F
MF
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra.
Hendry
I A
IA
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D009857:Oncogenes / Q000502:physiology*; D011986:Receptors, Somatotropin / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D011986:Receptors, Somatotropin; D019204:GTP-Binding Proteins