Histamine metabolism in nasal polyps.
We attempted to determine the relationship of nasal polyps to histamine (HA) metabolism. Compared to that in allergy-related nasal polyps and infection-related nasal polyps, the level of HA in aspirin-induced asthma-related polyps was significantly lower. Large differences between the groups were not observed in HA-synthesizing enzyme activity, but degradative enzyme activity was much higher in aspirin-induced asthma-related polyps than in other types  of nasal polyps tested. These findings suggest the possibility that the amount of HA in polyps associated with aspirin-induced asthma was less because of greatly enhanced degradation. We found, in addition, that in nasal tissues such as polyps, histamine-N-methyl transferase, rather than histaminase, was the principal degradative enzyme.
Ogino
S
S
Department of Otolaryngology, Faculty of Medicine, Osaka University, Japan.
Abe
Y
Y
Irifune
M
M
Harada
T
T
Matsunaga
T
T
Imamura
I
I
Fukui
H
H
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D001241:Aspirin; D001249:Asthma / Q000139:chemically induced / Q000150:complications; D001985:Bronchial Provocation Tests; D006632:Histamine / Q000378:metabolism*; D006637:Histamine N-Methyltransferase / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000378:metabolism; D006801:Humans; D009298:Nasal Polyps / Q000150:complications / Q000378:metabolism*; D012852:Sinusitis / Q000150:complications
D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D006637:Histamine N-Methyltransferase; D006640:Histidine Decarboxylase; D001241:Aspirin