title: Field evaluation of the efficacy of Romovac 50, a new inactivated, adjuvanted bovine rotavirus vaccine.
abstract: An inactivated bovine rotavirus vaccine, prepared with an adjuvant which gives a water-in-oil emulsion (Montanide ISA 50, adjuvant) was used in field trials for prevention of calf neonatal diarrhoea. The vaccine, which was designated as Romovac 50, when injected into cows in their last month of pregnancy, proved to be as effective as the traditional vaccine prepared with Freund's incomplete adjuvant. Thus, the incidence of the naturally occurring neonatal diarrhoea was significantly reduced in calves which were fed mammary secretion from their vaccinated dams, compared to the calves delivered from the unvaccinated cows. Romovac 50 also has the advantages over the traditional Freund's adjuvanted vaccine in that it is less viscous and thus more readily injected and less irritant to tissues.
authors.affiliation: Istituto di Malattie Infettive, Università di Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Castrucci
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.forename: V
authors.initials: V
authors.lastname: Angelillo
authors.forename: F
authors.initials: F
authors.lastname: Rigonat
authors.forename: L
authors.initials: L
authors.lastname: Capodicasa
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000096:biosynthesis; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D003126:Colostrum / Q000276:immunology; D003967:Diarrhea / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007112:Immunity, Maternally-Acquired; D007279:Injections, Subcutaneous / Q000662:veterinary; D011247:Pregnancy; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000517:prevention & control / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; C083609:Romovac 50; D015164:Vaccines, Inactivated; D014765:Viral Vaccines