title: Potential antitumor agents. XX (1). 6-Anilinoimidazo[2,1-b]thiazoles.
abstract: The synthesis of 6-anilinoimidazo[2,1-b]thiazoles, related to the well-known antitumor agent amsacrine, is reported. The cytotoxic activity of the new compounds was evaluated on HeLa cells. Compound 3a, the most closely related to amsacrine, was significantly active.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Andreani
authors.forename: M
authors.initials: M
authors.lastname: Rambaldi
authors.forename: A
authors.initials: A
authors.lastname: Locatelli
authors.forename: R
authors.initials: R
authors.lastname: Bossa
authors.forename: A
authors.initials: A
authors.lastname: Fraccari
authors.forename: I
authors.initials: I
authors.lastname: Galatulas
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D013844:Thiazoles