Prevention of runting and cachexia by a chimeric TNF receptor-Fc protein.
Tumor necrosis factor alpha (TNF) is an important mediator of septic shock and cachexia. A soluble form of the human type 2 TNF receptor, constructed by joining the Fc region of human IgG1 to the TNF receptor, prevents weight loss in nude mice bearing a TNF-secreting tumor. This soluble receptor was also used to treat TNF transgenic mice which were runting and died before reaching reproductive age. After continuous treatment with soluble TNF receptor, the TNF transgenic mice grew to normal size and reproduced. Thus, soluble TNF may be useful in counteracting the detrimental systemic effects of TNF in a clinical setting.
Teng
M N
MN
Department of Pathology, University of Chicago, Illinois 60637.
Turksen
K
K
Jacobs
C A
CA
Fuchs
E
E
Schreiber
H
H
D000818:Animals; D002100:Cachexia / Q000517:prevention & control*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005260:Female; D005856:Germ-Free Life; D006130:Growth Disorders / Q000517:prevention & control*; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000150:complications*; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors
D007141:Immunoglobulin Fc Fragments; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins