title: Controlled liver splitting for transplantation in two recipients: technique, results and perspectives.
abstract: A technique of controlled liver splitting for transplantation in two recipients is proposed, based on a full anatomical assessment of the graft including arteriography and cholangiography on the back-table. Using eight livers, 16 patients received a graft: right liver (eight patients), left lobe (four) or left liver (four). Twelve patients required urgent or very urgent transplantation. Anatomical assessment of the graft demonstrated a portal bifurcation in all cases, a common trunk of the left and middle hepatic veins in five, a right biliary duplication in three and duplication of the left branch of the middle hepatic artery in one. After revascularization of the graft, bleeding was greater in patients with a right graft, particularly if the middle hepatic vein had been ligated. The main postoperative complications were hepatic artery thrombosis (four cases), biliary complications (four), portal vein thrombosis (two), haematoma (two) and abscess (two). No primary non-function of the graft was observed. The postoperative survival rate was 75 per cent. The four patients in whom transplantation was not considered urgent are still alive. The immediate survival rate of the grafts was 69 per cent. These results compare favourably with those in the literature. In spite of the technical, logistical and ethical problems raised by this technique, the results suggest that controlled liver splitting for transplantation in two recipients may in the future significantly improve the feasibility of liver transplantation.
authors.affiliation: Clinique Chirurgicale, Hôpital Cochin, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Houssin
authors.forename: O
authors.initials: O
authors.lastname: Boillot
authors.forename: O
authors.initials: O
authors.lastname: Soubrane
authors.forename: C
authors.initials: C
authors.lastname: Couinaud
authors.forename: J
authors.initials: J
authors.lastname: Pitre
authors.forename: Y
authors.initials: Y
authors.lastname: Ozier
authors.forename: D
authors.initials: D
authors.lastname: Devictor
authors.forename: O
authors.initials: O
authors.lastname: Bernard
authors.forename: Y
authors.initials: Y
authors.lastname: Chapuis
mesh_terms: D000293:Adolescent; D000328:Adult; D016063:Blood Loss, Surgical; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D008099:Liver / Q000033:anatomy & histology* / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D014654:Vascular Patency