Vesicle monoamine transporters 1 and 2: differential distribution and regulation of their mRNAs in chromaffin and ganglion cells of rat adrenal medulla.
The expression and synthesis regulation of the vesicle monoamine transporter was investigated in rat adrenal medulla. Previous studies established two genes for monoamine transporters by molecular techniques. In rat adrenal medulla, a differential expression of the corresponding mRNAs was found by in situ hybridization. The mRNA of monoamine transporter 2 was localized in chromaffin cells whereas monoamine transporter 1 mRNA occurred only in ganglion cells of the adrenal medulla. Insulin-induced hypoglycemia, a model for short neurogenic stimulation of the adrenal medulla, did not alter steady-state mRNA levels of both monoamine transporters.
Mahata
S K
SK
Department of Pharmacology, University of Innsbruck, Austria.
Mahata
M
M
Fischer-Colbrie
R
R
Winkler
H
H
D000313:Adrenal Medulla / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002837:Chromaffin Granules / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis*; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism; D017403:In Situ Hybridization; D007328:Insulin / Q000494:pharmacology; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009479:Neuropeptides; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D050492:Vesicular Biogenic Amine Transport Proteins
D006023:Glycoproteins; D007328:Insulin; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009479:Neuropeptides; D012333:RNA, Messenger; D050492:Vesicular Biogenic Amine Transport Proteins