title: Biosynthesis in vitro of 2-(3-amino-3-carboxypropyl)-isoxazolin-5-one, the neurotoxic amino acid in Lathyrus odoratus.
abstract: 2-(3-Amino-3-carboxypropyl)-isoxazolin-5-one (ACI), a neurotoxic amino acid from Lathyrus odoratus, was confirmed to be derived enzymatically from S-adenosyl-L-methionine (SAM) and isoxazolin-5-one. Some properties of an enzyme in the biosynthesis of ACI are described.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Ikegami
authors.forename: R
authors.initials: R
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: F
authors.initials: F
authors.lastname: Lambein
authors.forename: I
authors.initials: I
authors.lastname: Murakoshi
mesh_terms: D000613:Aminobutyrates / Q000378:metabolism*; D007887:Fabaceae / Q000378:metabolism*; D007555:Isoxazoles / Q000378:metabolism*; D010946:Plants, Medicinal; D012436:S-Adenosylmethionine / Q000378:metabolism*
chemical_list: D000613:Aminobutyrates; D007555:Isoxazoles; C013076:isoxazolin-5-one; C083644:2-(3-amino-3-carboxypropyl)isoxazolin-5-one; D012436:S-Adenosylmethionine