title: Inhibitory effects of tannins on NADH dehydrogenases of various organisms.
abstract: We examined the effects of purified tannins and related compounds (33 species) on NADH-ubiquinone-1 oxidoreductase activity in four kinds of organism (Paracoccus denitrificans, Bacillus subtilis, Photobacterium phosphoreum, and Thermus thermophilus HB-8) and rat liver mitochondria. In addition to pentagalloylglucose, which was reported as a potent inhibitor of NADH dehydrogenases (NDH), sanguiin H-11, oolonghomobisflavan A, and polymerized procyanidin are potent inhibitors for both types of NDH (NDH-1 and NDH-2). We found that some other tannins contained in tea are also inhibitors of NDH from all organisms.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Konishi
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: N
authors.initials: N
authors.lastname: Ishigaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kanamura
authors.forename: I
authors.initials: I
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: I
authors.initials: I
authors.lastname: Nishioka
authors.forename: G
authors.initials: G
authors.lastname: Nonaka
authors.forename: I
authors.initials: I
authors.lastname: Horikoshi
mesh_terms: D000818:Animals; D001412:Bacillus subtilis / Q000201:enzymology; D001419:Bacteria / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000037:antagonists & inhibitors*; D010231:Paracoccus denitrificans / Q000201:enzymology; D010776:Photobacterium / Q000201:enzymology; D051381:Rats; D013367:Submitochondrial Particles / Q000201:enzymology; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology*; D016963:Thermus thermophilus / Q000201:enzymology
chemical_list: D013634:Tannins; D016660:NAD(P)H Dehydrogenase (Quinone)