Excess melanocytic nevi in children with renal allografts.
BACKGROUND
Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk.


OBJECTIVE
This study determines the prevalence of melanocytic nevi in children who have received renal allografts.


METHODS
Total and regional melanocytic nevi counts were made in 38 children (27 boys, 11 girls) with a renal allograft and in 38 individually age- and sex-matched healthy controls; counts were related to age, sex, skin type, and duration of immunosuppression.


RESULTS
There was a significant increase in the total number of nevi in the renal transplant group compared with the control group (p < 0.05), with most marked increases occurring on the back and at acral sites. A strong positive correlation between nevi count and duration of immunosuppression independent of age was observed (p < 0.005).


CONCLUSIONS
Excess numbers of melanocytic nevi occur in children with renal allografts. These patients constitute a risk group for malignant melanoma and require continued assessment.
Smith
C H
CH
Department of Dermatology, Guy's Hospital, London, England.
McGregor
J M
JM
Barker
J N
JN
Morris
R W
RW
Rigden
S P
SP
MacDonald
D M
DM
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000209:etiology / Q000517:prevention & control; D009508:Nevus, Pigmented / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors