[An unusual case of intercalary type of limb abnormalities].
Authors report about a case of total lack of middle phalanxes on the 3d and 4th fingers and a hypoplasia of the surrounding phalanges on the left hand. This is the first report on this type of intercalary type in congenital limb deficiency group. They call attention to one of the so far not sufficiently emphasized hazard of previous periconceptional oral contraceptive use. If there is not enough time left for the total regeneration after the discontinuation of contraceptives, such kind of malformation may develop in the fetus due to the insufficiency of fetal-placental circulation.
Göblyös
P
P
Orvostovábbképzö Egyetem, Radiológiai Klinika, Budapest.
Czeizel
E
E
D000014:Abnormalities, Drug-Induced; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects*; D005040:Ethynodiol Diacetate / Q000009:adverse effects*; D005260:Female; D005385:Fingers / Q000002:abnormalities*; D005817:Genetic Counseling; D006228:Hand Deformities, Congenital / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D008656:Mestranol / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D005040:Ethynodiol Diacetate; C018467:Bisecurin I; D008656:Mestranol