title: Propofol anesthesia reduces emesis and airway obstruction in pediatric outpatients.
abstract: This study was an authors comparison of the effects of and recovery from anesthesia in healthy, premedicated pediatric outpatients who received either inhaled anesthetics (group 1) or propofol (group 2). Group 1 (n = 68) averaged 3.8 +/- 0.2 yr and weighed 17.7 +/- 0.8 kg, whereas group 2 (n = 75) averaged 3.3 +/- 0.2 yr and weighed 16.3 +/- 0.6 kg. The incidence of vomiting in the Postanesthetic Care Unit (PACU) and from discharge to the first postoperative morning was lower in the group receiving propofol (0% and 18%) than in the group receiving volatile agents (7% and 34%, P < 0.05). The incidence of airway obstruction during induction of anesthesia was higher (34% vs 10%, P < 0.01) in children receiving inhaled agent. Withdrawal of the extremity with propofol injection occurred in 14 (19%) patients. Arterial blood pressure was higher at loss of consciousness, laryngoscopy, and tracheal intubation in group 2 (P < 0.01). The length of time from the end of surgery to extubation of the trachea, recovery scores, and length of time spent in the PACU and the Day Surgery Unit were the same in the two groups. Pain scores obtained in the PACU were not different. The data indicate that propofol can be used safely to induce and maintain anesthesia in healthy pediatric outpatients. This coupled with the low incidence of vomiting and airway obstruction in the propofol group suggests distinct and compelling reasons to consider using the drug in this patient population.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Pennsylvania.
authors.forename: T M
authors.initials: TM
authors.lastname: Martin
authors.forename: S C
authors.initials: SC
authors.lastname: Nicolson
authors.forename: M S
authors.initials: MS
authors.lastname: Bargas
mesh_terms: D000402:Airway Obstruction / Q000209:etiology*; D000556:Ambulatory Surgical Procedures; D000769:Anesthesia, Inhalation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006221:Halothane; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*; D015742:Propofol; D014839:Vomiting / Q000209:etiology*
chemical_list: D006221:Halothane; D015742:Propofol