[Simple methods of chloroquine determination in urine and their adaptation in the field].
Field malaria studies require often the on site detection of chloroquine in urine for monitoring chemoprophylaxis and treatment compliance, investigating drug-use patterns and screening prospective subjects for in vitro and in vivo chemosensitivity tests. The field adapted methods are described, analytical characteristics are compared and different approaches to field adapted assay of chloroquine are discussed.
Chaulet
J F
JF
Hôpital d'Instruction des Armées Desgenettes, Services pharmaceutiques et chimiques, Lyon.
Robet
Y
Y
Prevosto
J M
JM
Grelaud
G
G
Renard
C
C
Bellemin-Magninot
P
P
Lemontey
Y
Y
D002738:Chloroquine / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine*; D002845:Chromatography / Q000379:methods; D002985:Clinical Protocols; D003124:Colorimetry / Q000379:methods; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods*; D004351:Drug Resistance; D005069:Evaluation Studies as Topic; D006417:Hematuria / Q000150:complications; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007124:Immunoenzyme Techniques; D016778:Malaria, Falciparum / Q000150:complications / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D009391:Nephelometry and Turbidimetry / Q000379:methods; D010349:Patient Compliance; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D002738:Chloroquine