title: Analysis of phosphate kinetics in hemofiltration and hemodiafiltration: formulation of an efficiency index.
abstract: The kinetics of phosphate (P) during a treatment of hemofiltration or hemodiafiltration follows a simple exponential law, and P in 90 min reaches a stationary level that remains constant until the end of the treatment. The theoretical compartmental model cannot be estimated by a dialytic treatment, but a simpler diffusive model may be considered. Once the stationary level is reached, the net flux of P from the inaccessible compartments to the accessible compartment may be estimated via the parameters obtained in the exponential model. Hemodiafiltration seems more efficient than hemofiltration in determining P clearance. Thus an efficiency index that accounts for the period in which P is eliminated from the accessible compartment has been formulated.
authors.affiliation: Department of Nephrology, Ospedale Civile, Venice, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Maurizio
authors.forename: D C
authors.initials: DC
authors.lastname: Giannino
authors.forename: M
authors.initials: M
authors.lastname: Fabio
authors.forename: C
authors.initials: C
authors.lastname: Giovanni
authors.forename: L
authors.initials: L
authors.lastname: Cristina
authors.forename: G
authors.initials: G
authors.lastname: Laura
authors.forename: M
authors.initials: M
authors.lastname: Pietro
authors.forename: L
authors.initials: L
authors.lastname: Santino
authors.forename: G
authors.initials: G
authors.lastname: Silvio
authors.forename: N
authors.initials: N
authors.lastname: Carla
mesh_terms: D006440:Hemofiltration; D006801:Humans; D010710:Phosphates / Q000493:pharmacokinetics*; D006435:Renal Dialysis
chemical_list: D010710:Phosphates