title: Expression of monocyte chemoattractant protein 1 in human inflamed gingival tissues.
abstract: Gingival inflammation is initiated by bacterial colonization on the tooth surface. It is characterized by infiltration of mononuclear cells, a common feature of many forms of chronic inflammation. Monocyte chemoattractant protein 1 (MCP-1) is the predominant monocyte chemoattractant secreted by a variety of different cells in vitro. For this report, we examined MCP-1 expression in bacterially induced gingival inflammation by immunohistochemistry and in situ hybridization. The cell types expressing MCP-1 are identified as vascular endothelial cells and monocytes/macrophages. Correlation analysis shows that the number of cells expressing MCP-1 is related to the degree of inflammation. Our finding that MCP-1 is expressed in inflamed gingival tissue suggests that MCP-1 plays an important role in the recruitment of monocytes and amplification of inflammatory signals in bacterially induced inflammation.
authors.affiliation: Department of Oral Biology, Boston University School of Graduate Dentistry, Massachusetts 02118.
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: H N
authors.initials: HN
authors.lastname: Antoniades
authors.forename: D T
authors.initials: DT
authors.lastname: Graves
mesh_terms: D000328:Adult; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000032:analysis*; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D018932:Chemokine CCL2; D002630:Chemotactic Factors; D016207:Cytokines; D012333:RNA, Messenger