title: Skeletal muscle ventricles: left ventricular apex to aorta configuration.
abstract: Skeletal muscle ventricles (SMVs) were constructed from the latissimus dorsi muscle in 6 dogs. After 3 weeks of vascular delay followed by 6 weeks of 2-Hz continuous electrical conditioning, a valved conduit was placed between the left ventricular apex and the SMV and a second valved conduit, between the SMV and the aorta. The SMV was stimulated to contract during diastole at a 1:2 ratio with the heart. The SMV pumped 47% of the systemic blood flow initially (0.73 +/- 0.23 versus 1.54 +/- 0.42 L/min) and 40% after 3 hours. Skeletal muscle ventricle stimulation resulted in a 58% increase in mean diastolic pressure initially (52 +/- 9 to 82 +/- 11 mm Hg; p < 0.05) and a 73% increase (45 +/- 7 to 78 +/- 8 mm Hg) after 3 hours of continuous pumping. This was associated with a 68% increase in the endocardial viability ratio initially and a 63% increase at 3 hours. The systolic tension-time index decreased by 26% initially and 25% at 3 hours. This study indicates that the SMV configuration of left ventricular apex to aorta may be particularly suitable for left ventricular assist.
authors.affiliation: Department of Surgery, Wayne State University, Detroit, Michigan 48225.
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: R
authors.initials: R
authors.lastname: Fietsam
authors.forename: R L
authors.initials: RL
authors.lastname: Hammond
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: F W
authors.initials: FW
authors.lastname: Mocek
authors.forename: G A
authors.initials: GA
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Ruggiero
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: M
authors.initials: M
authors.lastname: Colson
authors.forename: L W
authors.initials: LW
authors.lastname: Stephenson
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology / Q000601:surgery*; D001705:Bioprosthesis; D001794:Blood Pressure / Q000502:physiology; D001807:Blood Vessel Prosthesis; D004285:Dogs; D004562:Electrocardiography; D006350:Heart Valve Prosthesis; D006352:Heart Ventricles / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics / Q000502:physiology*; D009132:Muscles / Q000637:transplantation*; D009200:Myocardial Contraction / Q000502:physiology; D010138:Pacemaker, Artificial; D011138:Polytetrafluoroethylene; D013318:Stroke Volume / Q000502:physiology; D013536:Suture Techniques; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D011138:Polytetrafluoroethylene