Increased levels of urinary interleukin-6 in Kawasaki disease.
Kawasaki disease (KD) often presents with abnormal urinary findings, such as aseptic pyuria, mild proteinuria and microscopic haematuria. In this study, we measured urinary interleukin-6 (IL-6) by a sensitive sandwich ELISA assay using mouse monoclonal antibodies against recombinant IL-6 to elucidate the role of IL-6 in the pathogenesis of renal lesions in KD. Serum IL-6 levels were increased in acute KD as well as in febrile controls. Importantly, urinary IL-6 levels were consistently elevated in patients with acute KD, but much lower in febrile controls. Urinary IL-6 levels returned steadily to normal during the convalescent phase. In addition to IL-6, urinary levels of N-acetyl-beta-D-glucosaminidase (NAG) and beta 2-microglobulin (beta 2-mg) were also elevated during the acute phase of this disease. Eosinophils and macrophages were identifiable in urinary sediments from these patients. The increased levels of urinary IL-6 in combination with increased NAG and beta 2-mg seemed to suggest the presence of certain renal parenchymal lesions with cellular infiltration during the acute phase of the disease. IL-6 may serve as clinically useful parameter for the detection and monitoring of the renal involvement in KD.
Ohta
K
K
Department of Paediatrics, School of Medicine, Kanazawa University, Ishikawa, Japan.
Seno
A
A
Shintani
N
N
Kato
E
E
Yachie
A
A
Seki
H
H
Miyawaki
T
T
Taniguchi
N
N
D000118:Acetylglucosaminidase / Q000652:urine; D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood / Q000652:urine*; D007674:Kidney Diseases / Q000209:etiology / Q000652:urine*; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000150:complications / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
D015850:Interleukin-6; D001613:beta 2-Microglobulin; D000118:Acetylglucosaminidase