Differential health benefits of weight loss in upper-body and lower-body obese women.
Upper-body obesity (UB Ob) is more strongly associated with adverse health consequences; however, few obesity-treatment studies have examined outcome according to body-fat distribution. To examine whether diet and formal- or informal-exercise instruction causes differential changes in health and lipid profiles, ten LB Ob and nine UB Ob premenopausal women received dietary intervention (2.1 MJ-deficit/d for 16 wk) and were randomly assigned to either formal- or informal-exercise instruction. Weight loss was similar between groups (approximately 8 kg), and no change occurred in lean body mass or basal metabolic rate. Baseline cholesterol and triglycerides were greater (P < 0.01) in UB Ob than LB Ob women and decreased more (P < 0.01) in response to treatment in UB Ob women. Formal exercise instruction increased high-density-lipoprotein cholesterol (P < 0.05) especially in UB Ob women. Future studies on treatment of obesity should include consideration of regional fat distribution.
Kanaley
J A
JA
Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905.
Andresen-Reid
M L
ML
Oenning
L
L
Kottke
B A
BA
Jensen
M D
MD
D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001481:Basal Metabolism; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000178:diet therapy / Q000628:therapy*; D010101:Oxygen Consumption; D011897:Random Allocation; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol