title: Bullous eruption with circulating pemphigus-like antibodies following interferon-alpha therapy.
abstract: Two patients with classic Kaposi sarcoma developed bullous lesions and pemphigus-like 'anti-intercellular-substance' antibodies when treated with interferon-alpha (IFN-alpha). In one of them direct immunofluorescence was consistent with pemphigus/pemphigoid features. The immunoprecipitation test showed no specific bands. The mechanism by which IFN-alpha may induce the production of anti-intercellular-substance antibodies is discussed.
authors.affiliation: Department of Dermatology, University of Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Parodi
authors.forename: M
authors.initials: M
authors.lastname: Semino
authors.forename: R
authors.initials: R
authors.lastname: Gallo
authors.forename: A
authors.initials: A
authors.lastname: Rebora
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D010392:Pemphigus / Q000209:etiology* / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000628:therapy; D012867:Skin / Q000276:immunology; D012878:Skin Neoplasms / Q000628:therapy
chemical_list: D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G; D016898:Interferon-alpha