title: Insulin-like growth factor-1 (IGF-1) and dehydroepiandrosterone sulphate in obese women.
abstract: Severe obesity is known to reduce either dehydroepiandrosterone circulating levels or growth hormone (GH) and insulin-like growth factor-1 (IGF-1) secretion. The present study was undertaken to evaluate the possibility of a relationship between the circulating levels of IGF-1 and those of dehydroepiandrosterone sulphate (DHEAS) in 25 fertile obese women. A logarithmic transformation of the values of non-normally distributed variables was performed before statistical analysis. We found a significant positive correlation between DHEAS and IGF-1 (r = 0.615, P < 0.01). In addition, stepwise multiple regression analysis showed that IGF-1 maintained a strong positive relationship with DHEAS (P < 0.01) when adjusted for other variables such as age, body mass index (BMI), waist:hip ratio (WHR) and insulin levels (adjusted R2 = 0.373; P < 0.01). These findings suggest that IGF-1 may independently influence the DHEAS circulating levels. ADG (5 alpha-androstan-3 alpha, 17 beta-diol-glucuronide) was also positively correlated to IGF-1 (r = 0.436, P < 0.05). However, when ADG concentrations were adjusted for DHEAS levels, this metabolite was not significantly correlated with IGF-1, thus excluding a direct influence of IGF-1 on the 5-alpha-reductase activity. Therefore, although our data represent only a preliminary study, they seem to suggest a possible influence of IGF-1 on circulating levels of DHEAS in obese women.
authors.affiliation: Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche dell'Università di Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: De Pergola
authors.forename: M R
authors.initials: MR
authors.lastname: Cospite
authors.forename: V A
authors.initials: VA
authors.lastname: Giagulli
authors.forename: F
authors.initials: F
authors.lastname: Giorgino
authors.forename: G
authors.initials: G
authors.lastname: Garruti
authors.forename: M
authors.initials: M
authors.lastname: Cignarelli
authors.forename: R
authors.initials: R
authors.lastname: Giorgino
mesh_terms: D000328:Adult; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000097:blood; D001824:Body Constitution; D015992:Body Mass Index; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D009765:Obesity / Q000378:metabolism*; D011863:Radioimmunoassay; D012044:Regression Analysis
chemical_list: D007328:Insulin; D015113:Androstane-3,17-diol; C028895:androstane-3,17-diol glucuronide; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone