title: Multiple brain metastases are associated with poor survival in patients treated with surgery and radiotherapy.
abstract: OBJECTIVE
  A retrospective analysis was performed to evaluate the role of surgery in the management of patients with solitary and multiple brain metastases.
  
  
  METHODS
  Between 1980 and 1990, 46 patients underwent surgical resection of brain metastases at the University of Colorado Health Sciences Center. All but two patients received postoperative whole-brain radiotherapy to a median total dose of 30 Gy (range, 11.4 Gy to 50.0 Gy). Lung was the most common (56%) primary site and adenocarcinoma was the most common (46%) tumor histology. Twenty-eight of 46 patients (61%) had solitary metastases, while the remaining 18 patients had two or more foci.
  
  
  RESULTS
  The median survival of all 46 patients was 11 months, and the 1- and 2-year survival rates were 40% and 12%, respectively. Moderately severe to severe neurologic impairment at the time of diagnosis and the presence of multiple brain metastases were associated with a significantly poorer survival. In patients with solitary metastasis, gross total resection and adenocarcinoma tumor histology significantly prolonged survival, whereas primary tumor site, the presence of active extracranial disease, and radiation dose had no significant effect on survival.
  
  
  CONCLUSIONS
  These results are consistent with a recent randomized study supporting the role of surgery and whole-brain radiation therapy in the management of patients with solitary brain metastases. We would caution against the generalization of this concept to patients with two or more brain metastases.
authors.affiliation: Division of Radiation Oncology, University of Colorado Health Sciences Center, Denver.
authors.forename: M B
authors.initials: MB
authors.lastname: Hazuka
authors.forename: W D
authors.initials: WD
authors.lastname: Burleson
authors.forename: D N
authors.initials: DN
authors.lastname: Stroud
authors.forename: C E
authors.initials: CE
authors.lastname: Leonard
authors.forename: K O
authors.initials: KO
authors.lastname: Lillehei
authors.forename: J J
authors.initials: JJ
authors.lastname: Kinzie
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis