Multimodality therapy in locally advanced cervical cancer.
In the past decade, neoadjuvant and concomitant multimodality therapies have been studied in patients with cervical cancer. The past year has witnessed more pilot studies confirming the feasibility of multimodality therapy. It is now time to move to prospective randomized clinical trials to determine the effects on disease-free intervals, to examine survival rates, and to define the ideal chemotherapeutic regimen and relationship to radiation therapy or surgery.
Runowicz
C D
CD
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY 10461.
Smith
H O
HO
Goldberg
G L
GL
D017024:Chemotherapy, Adjuvant / Q000379:methods / Q000592:standards*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D010865:Pilot Projects; D011878:Radiotherapy / Q000379:methods / Q000592:standards*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*