Comparison of platelet aggregability in Japanese type 2 diabetic patients with and without microalbuminuria.
Microalbuminuria is associated with higher cardiovascular morbidity and mortality in Type 2 (non-insulin-dependent) diabetic patients. This study was designed to assess whether Type 2 diabetic patients with microalbuminuria (urinary albumin excretion rate (AER) 20-200 microgram min-1) is associated with alterations in platelet aggregability as compared with those with normal urinary albumin excretion (AER < 20 microgram min-1). Platelet aggregability was compared between 21 Japanese Type 2 diabetic patients with microalbuminuria and 21 individually pair-matched (for age, sex, body mass index, treatment, and HbA1c level) patients with normoalbuminuria. The in vitro platelet aggregation induced by 1.0 and 3.0 mumol l-1 ADP and 0.5 and 1.0 mg l-1 collagen was measured using platelet-rich plasma. No significant differences were observed between the two groups in the values for maximum percent platelet aggregation, percent aggregation at 3 min, and aggregation velocities after adding ADP or collagen. Microalbuminuric patients had significantly higher mean values for systolic (p < 0.004) and diastolic (p < 0.02) blood pressures and plasma fibrinogen level (p < 0.03) as compared with the respective mean values in normoalbuminuric patients. The results suggest that Japanese microalbuminuric Type 2 diabetic patients do not differ in the degree of platelet aggregability as compared with normoalbuminuric patients, despite an increase in certain other coronary risk factors.
Baba
T
T
Clinical Research Institute, National Medical Centre, Tokyo, Japan.
Kodama
T
T
Yasuda
T K
TK
Ishizaki
T
T
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000419:Albuminuria; D001794:Blood Pressure; D003094:Collagen / Q000494:pharmacology; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology / Q000652:urine*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D007564:Japan; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects
D000244:Adenosine Diphosphate; D003094:Collagen; D003404:Creatinine; D006442:Glycated Hemoglobin