Study of HLA antigens in patients with osteosarcoma.
HLA typing was carried out in a group of twenty-four Spanish unrelated patients diagnosed with conventional high-grade osteosarcoma. All of them were typed for HLA-A and HLA-B antigens. A significant increase in the HLA-A11 (33.3 vs. 12%, chi 2 = 9.752, corrected p value = 0.016) and HLA-B7 (33.3 vs. 11.3%, chi 2 = 10.919, corrected p value = 0.011) was found in osteosarcoma patients compared with the control group. A trend towards an increased frequency in HLA-A24 and HLA-A28 antigens was also found.
Barona
P
P
Department of Pediatrics, Universitary Clinic, School of Medicine, University of Navarra, Pamplona, Spain.
Sierrasesúmaga
L
L
Antillón
F
F
Villa-Elízaga
I
I
D000293:Adolescent; D002648:Child; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000276:immunology*
D015234:HLA-A Antigens; D015235:HLA-B Antigens