[Flow cytometric analysis of the DNA content in resected thymomas].
Nuclear DNA contents were determined by flow cytometry in 31 resected thymomas. Ten (32%) of the 31 thymomas showed DNA aneuploid, and the presence of aneuploidy was well correlated with advanced clinical stage. Patients with an aneuploid tumor had a poor prognosis than those with a diploid tumor, demonstrating a survival rate of 50% at 7 years in aneuploidy compared to 100% at the same period in diploid patients (p < 0.05). In addition, patients with a high DNA index (DI > or = 1.5) tended to have a poor prognosis than those with a low DI. The analysis of DNA content can be an important prognostic index in patients with a thymoma.
Kushibe
K
K
Department of Surgery, Nara Medical College, Kashiwara, Japan.
Iioka
S
S
Nezu
K
K
Sawahata
A
A
Tojo
H
H
Kitamura
S
S
D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D015996:Survival Rate; D013945:Thymoma / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D013953:Thymus Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*
D004273:DNA, Neoplasm