title: Successful treatment of severe refractory sulfonylurea-induced hypoglycemia with octreotide.
abstract: OBJECTIVE
  To test the clinical use of octreotide in the treatment of sulfonylurea-induced hypoglycemia.
  
  
  METHODS
  A case is reported of sulfonylurea-induced hypoglycemic coma in a nondiabetic subject, which was complicated by relapse of hypoglycemia after resuscitation with intravenous dextrose. Subcutaneous octreotide, 50 micrograms 12 hourly, suppressed stimulated endogenous insulin secretion, thereby preventing a further recurrence of hypoglycemia.
  
  
  RESULTS
  No adverse effects of treatment were observed.
  
  
  CONCLUSIONS
  These results suggest a significant role for octreotide as an adjunct to intravenous dextrose in the management of severe and refractory cases of sulfonylurea-induced hypoglycemia.
authors.affiliation: Diabetic Clinic, General Hospital, Birmingham, United Kingdom.
authors.forename: A J
authors.initials: AJ
authors.lastname: Krentz
authors.forename: P J
authors.initials: PJ
authors.lastname: Boyle
authors.forename: K M
authors.initials: KM
authors.lastname: Justice
authors.forename: A D
authors.initials: AD
authors.lastname: Wright
authors.forename: D S
authors.initials: DS
authors.lastname: Schade
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D014044:Tolbutamide / Q000009:adverse effects*
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D014044:Tolbutamide; D015282:Octreotide