Renal lesions induced in F344/DuCrj rats by 4-weeks oral administration of dimethylarsinic acid.
The nephrotoxicity of dimethylarsinic acid (cacodylic acid, DMA) was examined in male and female F344/DuCrj rats. DMA administered perorally at doses of 113, 85, and 57 mg/kg for 4 weeks produced dose-related decreases in body weight and survival rate in both sexes. Mortality was higher and appeared more quickly in females than in males. Histopathological findings in the kidney were proximal tubular degeneration and necrosis, as well as papillary necrosis, and hyperplasia of the epithelium covering the papillae. Since extensive proximal tubular necrosis was observed only in dead animals of both sexes, and not in survivors or the controls, it was therefore concluded that the main cause of death could be attributed to nephrotoxicity of DMA. The results thus show that DMA is nephrotoxic to both male and female rats.
Murai
T
T
First Department of Pathology, Osaka City University Medical School, Japan.
Iwata
H
H
Otoshi
T
T
Endo
G
G
Horiguchi
S
S
Fukushima
S
S
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002101:Cacodylic Acid / Q000633:toxicity*; D005260:Female; D007673:Kidney Cortex Necrosis / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced*; D007681:Kidney Papillary Necrosis / Q000139:chemically induced; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D002101:Cacodylic Acid