Ethmoidal cancers: a retrospective study of 22 cases.
From April 1978 to June 1990, 22 patients with ethmoidal cancer were treated at Fondation Bergonié by a combination of surgery and radiation therapy. The mean age was 59.6 years (range 34-79 years) and the sex ratio is 2.7 (16 males/6 females). Histologic types were: adenocarcinoma, 13 cases; squamous carcinoma, 4 cases; undifferentiated carcinoma, 3 cases and esthesioneuroblastoma, 2 cases. Exposure to wood dust was encountered in 11 patients, especially in cases of adenocarcinoma: 10/13 (77%). Staging according to the classification of the University of Florida was: Stage I, 10 patients; Stage II, 5 patients and Stage III, 7 patients. Resection was considered as complete in 16 cases and only one orbital exenteration was performed. The postoperative radiation therapy delivered a mean given dose of 55.7 Gy (range 50-70 Gy) expressed to the hot spot using a technique adapted to tumor location and extension. Complete remission was achieved in 20 cases. Median follow-up is 28 months. The 5-year overall and disease-free survival are 44% and 38%, respectively. Analysis of recurrences according to staging gives: 5/10 Stage I, 2/5 Stage II and 5/7 Stage III. Recurrence is pejorative since death occurs in all cases within an average of 6 months following salvage treatment, except for three patients still alive within less than 6 months and in second remission. Prognosis of ethmoidal cancer depends on staging and local control.
Dilhuydy
J M
JM
Department of Radiotherapy, Fondation Bergonié, Comprehensive Cancer Center, Bordeaux, France.
Lagarde
P
P
Allal
A S
AS
Bécouarn
Y
Y
Soubeyran
P
P
Richaud
P
P
Faucher
A
A
Traissac
L
L
Stoll
D
D
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D003131:Combined Modality Therapy; D004391:Dust; D005005:Ethmoid Sinus; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000453:epidemiology / Q000628:therapy; D016273:Occupational Exposure; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate; D014934:Wood
D004391:Dust