title: Acute myocardial infarction complicating urokinase infusion for total saphenous vein graft occlusion.
abstract: Saphenous vein graft occlusions have been successfully treated with extended urokinase infusions. We report a case of myocardial infarction complicating this treatment. A review of reported cases suggests that this complication may not be uncommon. The optional drug, dose, and infusion technique for intra-graft lytic therapy has not been determined. The costs, risks, and difficulty of this technique may limit its application.
authors.affiliation: Department of Cardiology, Geisinger Medical Center, Danville, PA 17822.
authors.forename: J C
authors.initials: JC
authors.lastname: Blankenship
authors.forename: T A
authors.initials: TA
authors.lastname: Modesto
authors.forename: N P
authors.initials: NP
authors.lastname: Madigan
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000209:etiology; D001026:Coronary Artery Bypass; D003365:Costs and Cost Analysis; D006083:Graft Occlusion, Vascular / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*; D012501:Saphenous Vein / Q000637:transplantation*; D015912:Thrombolytic Therapy / Q000009:adverse effects* / Q000379:methods; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014568:Urokinase-Type Plasminogen Activator