The effect of calcium channel blockade during electroconvulsive treatment on cerebral cortical adrenoceptor subpopulations in the rat.
Chronic administration of nifedipine (5 mg/kg/day for 10 days) induced some biochemical effects consistent with those of antidepressants: a significant depression in cortical alpha 2-adrenoceptor density and reduction of beta-adrenoceptor affinity; nifedipine co-administration with electroconvulsive treatment potentiated the beta-downregulatory effect of the latter.
Antkiewicz-Michaluk
L
L
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Michaluk
J
J
Romańska
I
I
Vetulani
J
J
D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry* / Q000187:drug effects; D004565:Electroconvulsive Therapy; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009543:Nifedipine