title: Microbial glycosidation of some anthracycline antibiotics by an antibiotic-negative mutant of aclarubicin producer.
abstract: Microbial conversion of anthracyclinone monosaccharides using aclarubicin-negative mutant of Streptomyces galilaeus was found to produce anthracyclinone disaccharides which had either rhodinose or 2-deoxyfucose as an additional sugar. By this conversion we obtained twelve new anthracyclines from seven anthracyclines which had rhodosamine, N-monomethyldaunosamine or daunosamine at C-7 as a glycosidic sugar. All products had a reduced cytotoxic activity in comparison with those of parent compounds. However, some of them showed a therapeutically improved antitumor effects against L1210 leukemia in vivo.
authors.affiliation: Central Research Laboratories, Mercian Corporation, Fujisawa, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Johdo
authors.forename: H
authors.initials: H
authors.lastname: Tone
authors.forename: R
authors.initials: R
authors.lastname: Okamoto
authors.forename: A
authors.initials: A
authors.lastname: Yoshimoto
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: T
authors.initials: T
authors.lastname: Sawa
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D015250:Aclarubicin / Q000096:biosynthesis*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D006031:Glycosylation; D007939:Leukemia L1210 / Q000473:pathology; D009154:Mutation; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; D015250:Aclarubicin