[A pathogenetic hypothesis based on the use of chlorpromazine of organic disorders probably due to microcirculatory changes].
In the introduction it is noted that, in the physiopathology, specific pathogenetic elements are missing concerning irritative stimulation, turbid fat pathosis, digital hippocratism of chronic affections (for example, pulmonary affections), the most frequent onset of telarche and of the swelling of the areola of the breast on the left hemithorax in the premenstrual syndrome, fibrosis, cyrrosis, certain types of insipid diabetes, etc. In the opinion of the author, the use of chloropromazine, in doses that have proved to be harmless, has contributed to the clearing up of some questions concerning a few pathologies of internal organs: the liver, the spleen, the brain-and enable us to pose some hypotheses about the swelling of the liver, the origin of scleroses and cirrhoses and some splenic and encephalic swellings. The author suggests that the fundamental reason is to be sought in changes in the microcirculation which are linked to insufficient capillary and sinusoidal circulation. Two cases of insipid diabetes are mentioned which were treated with chloropromazine and for which an improvement in the trophism of the diencephalic cells was hypothesized, due to an improvement in the local circulation. A similar physiopathological microcirculatory behaviour is attributed to digital hippocratism, the P. Marie and Bamberger syndrome (similar to those determined by cyanotic congenital cardiopathies), both due to chronic suppurative processes, and the slightly more frequent onset of telarche on the left hemithorax. It is expected that other pathologies may be explained by a similar physiopathological mechanism, malignant tumor inclusive.
Malossi
M
M
L.D. di Clinica Pediatrica, U.S.L. C5, Trento, Italia.
D002746:Chlorpromazine / Q000008:administration & dosage*; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006529:Hepatomegaly / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008099:Liver / Q000098:blood supply* / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D013154:Spleen / Q000098:blood supply* / Q000187:drug effects; D013163:Splenomegaly / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors
D002746:Chlorpromazine