title: Complications and surgical indications in 144 cases of nonmetastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy.
abstract: From September 1986 to December 1989, 144 patients with osteosarcoma of the extremities were treated with combined surgery and neoadjuvant chemotherapy. The disease-free survival was 79% for good responders (necrosis greater than 90%) and 72% for poor responders (necrosis less than 90%), and the local recurrence rate was low. Improvement in long-term prognosis and the increase of limb-sparing surgery determine a higher rate of immediate and late complications. Most of the complications were observed in limb-salvage procedures; 63% of these procedures presented one or more complications. In nine rotationsplasties, there were four complications, and in 13 amputations no complications were observed. Therefore, 55% of patients were affected by surgical complications. Twenty-eight complications were considered minor (not requiring surgery), whereas 77 complications were major. Functional results, evaluated according to Enneking's new system, were higher than 50% in two thirds of the limb-salvage procedures. Complications in limb-salvage procedures are more influenced by the type of reconstruction than by the surgical procedure used. Probably the most troublesome consequence of surgical complications in osteosarcoma is the deviation or delay in administering postoperative chemotherapy, which jeopardizes survival.
authors.affiliation: Department of Orthopaedics, University of Bologna, Instituto Ortopedico Rizzoli, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ruggieri
authors.forename: R
authors.initials: R
authors.lastname: De Cristofaro
authors.forename: P
authors.initials: P
authors.lastname: Picci
authors.forename: G
authors.initials: G
authors.lastname: Bacci
authors.forename: R
authors.initials: R
authors.lastname: Biagini
authors.forename: R
authors.initials: R
authors.lastname: Casadei
authors.forename: A
authors.initials: A
authors.lastname: Ferraro
authors.forename: A
authors.initials: A
authors.lastname: Ferruzzi
authors.forename: N
authors.initials: N
authors.lastname: Fabbri
authors.forename: A
authors.initials: A
authors.lastname: Cazzola
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D005260:Female; D005266:Femoral Neoplasms / Q000188:drug therapy / Q000601:surgery; D005360:Fibula; D006801:Humans; D006811:Humerus; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery*; D011183:Postoperative Complications; D011884:Radius; D016019:Survival Analysis; D013977:Tibia