The host response in graft versus host disease. I. Radiosensitive T cells of host origin inhibit parental anti-F1 cytotoxicity in murine chronic graft versus host disease.
Murine graft versus host (GVH) disease takes two forms depending on the parental/F1 strain combination employed. Acute lethal GVH disease is characterized by anemia, lymphopenia, hypogammaglobulinemia, profound anti-F1 cytotoxicity, and the loss of cytotoxic potential against third-party alloantigen. In contrast to this, chronic GVH disease is characterized by polyclonal B cell activation, auto-antibody production, no anti-F1 cytotoxicity, and retained cytotoxicity against allotargets. We now report that this marked disparity in disease expression results from a radio-sensitive host mechanism which protects the F1 mouse from parental anti-F1 cytotoxicity in mice undergoing chronic GVH disease. Cellular analysis revealed that protection in chronic GVH disease is mediated by a phenotypically complex system of genetically unrestricted radiosensitive T cells of F1 origin. These cells fail to functionally emerge in mice undergoing acute lethal GVH disease.
Singh
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AB
Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Hiehle
K
K
Singh
M
M
Jetzt
A E
AE
O'Connell
S M
SM
Mann
R A
RA
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic / Q000502:physiology*; D006086:Graft vs Host Disease / Q000235:genetics / Q000276:immunology*; D006183:H-2 Antigens / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011836:Radiation Tolerance; D017634:Self Tolerance; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects
D006183:H-2 Antigens