Pilot study analysis of the histologic and bacteriologic effects of occlusive dressings in chemosurgical peel using a minipig model.
The histologic changes associated with chemosurgery are well documented, but the data concerning the effects of occlusive dressings (adhesive tape, gauze, or ointments) is largely anecdotal. Wide differences of opinion exist as to the best method of phenol application and postpeel wound care regimen. Using a Yucatan minipig as our animal model, we studied the histologic and bacteriologic differences that various commonly used occlusive dressings have upon the initial burn depth and the subsequent healing of peeled skin. We also compared chemical peel with dermabrasion and chemabrasion. Our results showed to statistical difference in peel depth between "wet" versus "moist" phenol application or between occluded versus nonoccluded dressings. Based upon this animal model, we recommend that phenol solutions be applied moist rather than wet and that an occlusive dressing other than adhesive tape be used and maintained for a minimum of four days.
Zukowski
M L
ML
Mossie
R D
RD
Roth
S I
SI
Giese
S
S
McKinney
P
P
D000818:Animals; D002615:Chemexfoliation / Q000379:methods / Q000592:standards*; D003131:Combined Modality Therapy; D003869:Dermabrasion / Q000379:methods / Q000592:standards; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005069:Evaluation Studies as Topic; D005260:Female; D009779:Occlusive Dressings / Q000592:standards*; D019800:Phenol; D010636:Phenols / Q000008:administration & dosage* / Q000627:therapeutic use; D010784:Photomicrography; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects* / Q000382:microbiology; D013552:Swine; D013556:Swine, Miniature; D014945:Wound Healing
D010636:Phenols; D019800:Phenol