title: Neurotropism of mouse-adapted haemagglutinating encephalomyelitis virus.
abstract: The propagation of a mouse-adapted strain (67N) of haemagglutinating encephalomyelitis virus in infected mice and murine cells was examined by viral re-isolation and immunostaining. Viral propagation was strictly limited to the neurons and to an established line of neuroblastoma cells in in-vivo and in-vitro experiments. These results provide adequate evidence that this virus is neurotropic.
authors.affiliation: Laboratory Animal Research Center, University of Tsukuba, Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yagami
authors.forename: Y
authors.initials: Y
authors.lastname: Izumi
authors.forename: N
authors.initials: N
authors.lastname: Kajiwara
authors.forename: F
authors.initials: F
authors.lastname: Sugiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiyama
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000382:microbiology; D002478:Cells, Cultured; D017934:Coronavirus / Q000302:isolation & purification / Q000502:physiology*; D018352:Coronavirus Infections / Q000473:pathology / Q000503:physiopathology; D005347:Fibroblasts / Q000166:cytology / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D009447:Neuroblastoma / Q000382:microbiology / Q000473:pathology; D009474:Neurons / Q000382:microbiology* / Q000473:pathology / Q000502:physiology; D014407:Tumor Cells, Cultured; D014779:Virus Replication