Effects of rice bran hemicellulose on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in Fischer 344 rats.
The effect of rice bran hemicellulose (RBH) on 1,2-dimethylhydrazine- (DMH) induced intestinal carcinogenesis was studied in male Fischer 344 rats. Rats were fed a basal control diet or a diet containing 2% or 4% RBH at five weeks of age. At 6 weeks of age, all animals were given an intraperitoneal injection of DMH (20 mg/kg body wt) at weekly intervals for 20 weeks and autopsied 7 weeks after the last injection. The incidence of DMH-induced colon tumors was significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The number of colon tumors per rat was also significantly lower in rats fed the 4% RBH diet than in rats fed the basal control diet (p < 0.05). The present study suggested that the water-soluble RBH played a preventive role in DMH-induced large bowel carcinogenesis in Fischer 344 rats.
Aoe
S
S
Technical Research Institute, Snow Brand Milk Products, Saitama, Japan.
Oda
T
T
Tojima
T
T
Tanaka
M
M
Tatsumi
K
K
Mizutani
T
T
D019813:1,2-Dimethylhydrazine; D000143:Acids / Q000032:analysis; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002273:Carcinogens; D002432:Cecum / Q000737:chemistry; D004127:Dimethylhydrazines; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000178:diet therapy*; D008297:Male; D012275:Oryza; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D000143:Acids; D002273:Carcinogens; D004127:Dimethylhydrazines; D011134:Polysaccharides; C007916:hemicellulose; D019813:1,2-Dimethylhydrazine