HSV-1 neuroinvasiveness.
Neuroinvasiveness, the capacity of virus to enter and progress through the nervous system, may be accomplished by hematogenous or neural routes. We have been interested in defining HSV-1 genes specifically concerned with the neural pathway. In one system (involving HSV strain Ang), we have found that a single amino acid change in glycoprotein D, a viral membrane protein, confers invasiveness upon a noninvasive agent. Preliminary studies of another noninvasive agent, KOS, suggests that at least 2 genes are related to the phenotype. Experiments which establish specificity for the noninvasive phenotype and a discussion of the potential mechanisms involved in the glycoprotein D localization are also discussed.
Stevens
J G
JG
Department of Microbiology and Immunology, UCLA School of Medicine 90024-1747.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral; D006561:Herpes Simplex / Q000382:microbiology*; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D008969:Molecular Sequence Data; D009420:Nervous System / Q000382:microbiology*; D014779:Virus Replication
D004279:DNA, Viral