Overview of pup in a cup model: hepatic lipogenesis in rats artificially reared on a high-carbohydrate formula.
The artificial rearing technique allows nutritional investigations to be conducted in rat pups during a critical period that previously has been inaccessible to researchers. The technique will be useful for identifying dietary components contributing to metabolic adaptations in the preweaning period as well as "metabolic imprinting" or permanent metabolic effects in adult rats resulting from early dietary intervention. Artificially reared rat pups fed a formula high in carbohydrate-derived energy in the preweaning period have the following characteristics compared with pups fed a high-fat formula or reared naturally: (i) a higher level of plasma insulin, (ii) an increased hepatic lipogenic capacity and (iii) precocious induction of hepatic malic enzyme. The results also show that early exposure to a high-carbohydrate diet in the preweaning period predisposes the rat to an increased lipogenic capacity in liver and adipose tissues and to the development of obesity later in adult life.
Patel
M S
MS
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Vadlamudi
S P
SP
Johanning
G L
GL
D000818:Animals; D000831:Animals, Newborn; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008954:Models, Biological; D051381:Rats
D004040:Dietary Carbohydrates