title: [Deficiency of mannan-binding protein--a recently discovered complement defect syndrome].
abstract: Mannan-binding protein (MBP) is a newly discovered serum protein which activates the complement system by the classical pathway by binding to mannose-rich surfaces on microorganisms. MBP deficiency predisposes to infection in infancy. MBP is a C-type lectin with collagen structure, a so-called collection. The paper discusses the structure and physiological functions of MBP. MBP may be an important parameter in the investigation of immunodeficiencies in children.
authors.affiliation: Vaevstypelaboratoriet, Rigshospitalet, København.
authors.forename: P
authors.initials: P
authors.lastname: Garred
authors.forename: S
authors.initials: S
authors.lastname: Thiel
authors.forename: H O
authors.initials: HO
authors.lastname: Madsen
authors.forename: L P
authors.initials: LP
authors.lastname: Ryder
authors.forename: J C
authors.initials: JC
authors.lastname: Jensenius
authors.forename: A
authors.initials: A
authors.lastname: Svejgaard
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry* / Q000276:immunology; D037222:Collectins; D003171:Complement Pathway, Classical / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000276:immunology; D007223:Infant; D011951:Receptors, Complement / Q000276:immunology / Q000378:metabolism; D013577:Syndrome
chemical_list: D002352:Carrier Proteins; D037222:Collectins; D011951:Receptors, Complement