Temporal lobe epilepsy in early childhood.
To explore the electroclinical features of temporal lobe epilepsy (TLE) in early childhood, we studied results of video-EEG and other tests of 14 children aged 16 months to 12 years selected by seizure-free outcome after temporal lobectomy. Four children had mesiotemporal sclerosis, 1 had cortical dysplasia, and 9 had low-grade temporal neoplasms. The children had complex partial seizures (CPS) with symptomatology similar to that of adults with TLE, including decreased responsiveness and automatisms. Automatisms tended to be simpler in the younger children, typically limited to lip smacking and fumbling hand gestures. Scalp/sphenoidal EEG showed anterior/inferior temporal interictal sharp waves and unilateral temporal seizure onset in the 4 children with mesiotemporal sclerosis and in the child with cortical dysplasia, but EEG findings in 9 children with low-grade temporal tumors were complex, including multifocal interictal sharp waves or poorly localized or falsely lateralized EEG seizure onset. In children without tumors, video-EEG was critical to localization of the epileptogenic zone for resection, but in patients with tumors video-EEG was less localizing and its main value was to confirm that the reported behaviors were epileptic seizures with semiology typical of temporal lobe onset.
Wyllie
E
E
Department of Neurology, Cleveland Clinic Foundation, Ohio 44195-5221.
Chee
M
M
Granström
M L
ML
DelGiudice
E
E
Estes
M
M
Comair
Y
Y
Pizzi
M
M
Kotagal
P
P
Bourgeois
B
B
Lüders
H
H
D000367:Age Factors; D001927:Brain Diseases / Q000175:diagnosis / Q000503:physiopathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000503:physiopathology; D002540:Cerebral Cortex / Q000002:abnormalities / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D012598:Sclerosis / Q000175:diagnosis / Q000503:physiopathology; D013702:Temporal Lobe / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014743:Videotape Recording