[Review of findings on binding of tricyclic antidepressants].
Authors summarize knowledge in the field of the high-affinity binding of tricyclic antidepressants on cell membranes within last 12 years. Some ideas about the significance of such binding are stated. Both the data from papers and our knowledge are discussed with regard to the possibility of their clinical application at depressed patients. Effects of the tricyclic antidepressants are linked with their influence on the active transport of neuromediators through the cell membrane but their molecular mechanisms are unknown. Present-day state of research is described and the orientation on the role of membrane phospholipids in the binding studies of the tricyclic antidepressants is emphasized.
Krulík
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R
Výzkumná psychiatrická laborator 1. LF UK, Praha.
Fisar
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Z
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000493:pharmacokinetics*; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism; D006801:Humans
D000929:Antidepressive Agents, Tricyclic