A synaptic model of memory: long-term potentiation in the hippocampus.
Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.
Bliss
T V
TV
Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK.
Collingridge
G L
GL
D000818:Animals; D002118:Calcium / Q000502:physiology; D004594:Electrophysiology; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D008568:Memory; D008959:Models, Neurological; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium