Submandibular salivary gland hypertrophy induced by phenytoin.
A 16-year-old boy with epilepsy developed hypertrophy of the submandibular salivary glands, with high phenytoin (PHT) serum levels. The submandibular salivary glands became normal in 12 days after discontinuation of PHT. Other causes of salivary gland hypertrophy were excluded and we suggest that the hypertrophy was due to PHT.
Brandenburg
A H
AH
Department of Pediatrics, Gelderse Vallei Hospital, Ede, The Netherlands.
Smits
M G
MG
Voorbrood
B S
BS
Hemmes
A M
AM
Ros
J J
JJ
D000293:Adolescent; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*; D012466:Salivary Gland Diseases / Q000139:chemically induced*; D013363:Submandibular Gland / Q000473:pathology*
D010672:Phenytoin