title: Functional imaging, the frontal lobes, and dementia.
abstract: A 58-year-old man developed progressive difficulty with comprehension and verbal output with dementia. Positron emission tomography with 18F 2-fluoro-2-deoxy-D-glucose demonstrated asymmetrical frontal and anterior temporal lobe loss of glucose use. Scopolamine infusion (0.3 mg) did not influence memory. Postmortem studies revealed evidence of Pick's disease, with Pick bodies, loss of somatostatin, preservation of choline acetyltransferase and immunostaining with neurofilament antibodies. Pharmacological challenge and positron imaging offer valuable means for the noninvasive assessment of dementing illness. The contributions of functional imaging to our knowledge of frontal involvement in dementing illness are reviewed.
authors.affiliation: Alzheimer Center, University Hospital of Cleveland, OH 44106.
authors.forename: R P
authors.initials: RP
authors.lastname: Friedland
authors.forename: E
authors.initials: E
authors.lastname: Koss
authors.forename: A
authors.initials: A
authors.lastname: Lerner
authors.forename: P
authors.initials: P
authors.lastname: Hedera
authors.forename: W
authors.initials: W
authors.lastname: Ellis
authors.forename: N
authors.initials: N
authors.lastname: Dronkers
authors.forename: B A
authors.initials: BA
authors.lastname: Ober
authors.forename: W J
authors.initials: WJ
authors.lastname: Jagust
mesh_terms: D001923:Brain Chemistry / Q000502:physiology; D003704:Dementia / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D005625:Frontal Lobe / Q000000981:diagnostic imaging*; D005947:Glucose / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012601:Scopolamine; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D012601:Scopolamine; D005947:Glucose