[Studies on tissue concentration of tegafur, 5-fluorouracil, uracil after UFT administration together with the study of microangiography of colorectal cancer].
In order to elucidate the effect of tumor vascularity on a various regimens concentration in tumor tissue, correlation among tegafur, 5-fluorouracil (5-FU), uracil concentrations in tissue and the microangiography were examined in 27 patients with colorectal cancer after preoperative administration of UFT (400 mg/day for 7 days). The concentrations of tegafur, 5-FU and uracil in tumor were higher than those in normal tissue (p < 0.01). There was no definite correlation between tissue concentration in each regimen and the extra or intramural vascular changes. A significant high concentration of 5-FU was found in the protuberant cancer and the ulcerative cancer with horizontal growth than that in the ulcerative cancer with vertical growth (p < 0.05). The present study indicates that the vascular changes within a tumor and the vascular pattern of tumor may be a contributing factor affecting the tissue concentration in the regimens.
Shimoyama
T
T
1st Dept. of Surgery, Nagasaki University School of Medicine.
Shimizu
T
T
Kusano
H
H
Ishikawa
H
H
Miyashita
K
K
Nakazaki
T
T
Yasutake
T
T
Yoshida
A
A
Yoshida
K
K
Ogawa
T
T
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000971:Antineoplastic Combined Chemotherapy Protocols; D002851:Chromatography, High Pressure Liquid; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005472:Fluorouracil / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D005641:Tegafur / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D014498:Uracil / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics
D000970:Antineoplastic Agents; D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil