[ Multigeneration carcinogenesis in the evaluation and prognosis of delayed radiation effects].
Radiation multigeneration carcinogenesis' mechanisms are associated with inheritance of non-specific genome lesions. Evidence indicates that the effect is significantly enhanced by some chemical carcinogens action on the offspring of irradiated parents. Hereditary character of the phenomenon is a prerequisite to accumulation of these genetic determinants in the population. The risk of radiation multigeneration carcinogenesis for man could be as much as 0.4 x 10(-2) Sv-1 over one generation.
Malakhovskiĭ
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Antonov
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D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005799:Genes, Dominant / Q000528:radiation effects; D006801:Humans; D051379:Mice; D016296:Mutagenesis / Q000528:radiation effects*; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D011379:Prognosis; D051381:Rats; D013997:Time Factors