Short-term effect of cyclosporin injections on experimental gingival inflammation in the rat.
Experimental gingivitis was induced in 2 groups of 10 adult Wistar rats by feeding them a high sucrose diet for 30 days. Since cyclosporin has an immunosuppressive effect on the stimulation of T lymphocytes, the test group received 5 intraperitoneal injections of cyclosporin A from day 20 to 30 while the control group received no additional treatment. The gingival regions of the molars were studied in light and transmission electron microscopy. In both groups, a well-differentiated wall of polymorphonuclear neutrophils (PMNs) was present between the dental plaque and the papillary epithelium and no bacterial invasion occurred despite the local absence of T lymphocytes in the test group. It can be concluded that T lymphocytes are not involved in the mechanism of bacterial invasion.
Hemmerle
J
J
Centre de Recherches, Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg, France.
Frank
R M
RM
D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects* / Q000276:immunology; D003773:Dental Plaque / Q000382:microbiology; D005881:Gingiva / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D005891:Gingivitis / Q000276:immunology* / Q000382:microbiology; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008854:Microscopy, Electron; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D013395:Sucrose; D016572:Cyclosporine