Renal effects of a nonhypotensive i.v. dose of felodipine.
To evaluate the natriuretic effect of a nonhypotensive dose of felodipine, 11 healthy volunteers (age: 21-28 years) on a high-sodium diet received the drug or its vehicle in a double-blind, randomized, crossover study. Administered intravenously at a dose level of 7.5 micrograms/min for 30 minutes followed by 5 micrograms/min for 120 minutes, felodipine increased natriuresis (546 +/- 69 vs. 454 +/- 39 mumol/min, P < 0.001) and diuresis (8.9 +/- 0.6 vs. 7.5 +/- 0.5 mL/min), compared to its vehicle. Renal plasma flow tended to be augmented, but there was a significant reduction of renal vascular resistance (0.085 +/- 0.004 vs. 0.101 +/- 0.012 mm Hg/mL/min, P < 0.03). The glomerular filtration rate was slightly decreased and proximal sodium reabsorption was diminished with no measurable effect on distal function. Felodipine stimulated plasma renin activity, but produced no changes in plasma atrial natriuretic factor, cGMP, aldosterone, and atrial vasopressin levels. In conclusion, felodipine induced natriuresis and diuresis while reducing proximal tubular sodium reabsorption.
Larochelle
P
P
Institut de Recherches Cliniques de Montréal, Quebec, Canada.
Cusson
J R
JR
du Souich
P
P
Thibault
G
G
Edgar
B
B
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D015736:Felodipine / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D014677:Pharmaceutical Vehicles; D014655:Vascular Resistance / Q000187:drug effects
D014677:Pharmaceutical Vehicles; D015736:Felodipine