Recent advances in molecular and genetic analysis of Rh blood group structures.
The Rh antigens are carried by 30-32 kDa integral proteins of the red cell membrane. The Rh locus is composed of two genes: RhD, which encodes the major D antigen and is present only in Rh-positive genomes, and RhCcEe, which encodes both the Cc and Ee polypeptides, most likely by alternative splicing events. The D and non-D Rh mRNAs have been cloned. Their sequence homology suggest that the two Rh genes have evolved by duplication of a common ancestor.
Colin
Y
Y
Unité INSERM U76, Institut National de Transfusion Sanguine, Paris, France.
Cherif-Zahar
B
B
Le Van Kim
C
C
Mouro
I
I
Cartron
J P
JP
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D004910:Erythrocyte Membrane / Q000737:chemistry; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics; D012204:Rh-Hr Blood-Group System / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology
D012333:RNA, Messenger; D012204:Rh-Hr Blood-Group System