title: Strong genetic association between HLA-DR3 and a polymorphic variation in the regulatory region of the HSP70-1 gene.
abstract: A three-allele polymorphic system is detectable by direct electrophoretic analysis of the amplified 5' untranslated und 5' flanking regions of the HLA-linked HSP70-1 gene. Single nucleotide differences at two sites, i.e., -110 and +120, are responsible for changes in the bending pattern and, consequently, in the electrophoretic mobility of the three alleles. The presence of the sequence AAACCCC around position -110 is strongly associated with DR3.
authors.affiliation: Institute of Cell Biology, CNR, Rome, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Cascino
authors.forename: R
authors.initials: R
authors.lastname: Sorrentino
authors.forename: R
authors.initials: R
authors.lastname: Tosi
mesh_terms: D001483:Base Sequence; D005809:Genes, Regulator; D008040:Genetic Linkage; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
chemical_list: D015803:HLA-DR3 Antigen; D006360:Heat-Shock Proteins