title: The combined assessment of cellular apoptosis, mitochondrial function and proliferative response to pokeweed mitogen has prognostic value in SIV infection.
abstract: Using the assessment of the mitochondrial metabolic activity of freshly isolated blood mononuclear cells, the flow cytometric detection of apoptosis and of the proliferative responses to PWM, SIV-infected macaques were classified in: stage 0, which included all animals with unaffected parameters, and stages 1, 2, and 3, which included animals having one, two, or all three parameters affected, respectively. This novel three-parametric staging system (ISS) provides a new prognostic tool in the longitudinal study of SIV infection.
authors.affiliation: Department of Microbiology and Medical Zoology, University of Puerto Rico, San Juan 00936-5067.
authors.forename: A M
authors.initials: AM
authors.lastname: del Llano
authors.forename: J P
authors.initials: JP
authors.lastname: Amieiro-Puig
authors.forename: E N
authors.initials: EN
authors.lastname: Kraiselburd
authors.forename: M J
authors.initials: MJ
authors.lastname: Kessler
authors.forename: C A
authors.initials: CA
authors.lastname: Málaga
authors.forename: J A
authors.initials: JA
authors.lastname: Lavergne
mesh_terms: D000818:Animals; D017209:Apoptosis; D015658:HIV Infections / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D008928:Mitochondria / Q000378:metabolism*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011379:Prognosis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors
chemical_list: D011043:Pokeweed Mitogens