Link between Helicobacter pylori-associated gastritis and duodenal ulcer.
We examined the interrelationships among the degree of fundic mucosal atrophy, the prevalence of Helicobacter pylori in the gastric antrum, the gastric juice, and the duodenum with and without gastric metaplasia, in 20 duodenal ulcer patients and 20 non-duodenal ulcer patients. The detection rates of H. pylori in the antrum, the gastric juice, and the duodenum were significantly higher in duodenal ulcer patients (80%, 65%, and 60%) than in non-duodenal ulcer subjects (50%, 20%, and 5%). The frequency of H. pylori was significantly lower in the gastric juice (30%) and the duodenum (10%) in non-duodenal ulcer patients with antral H. pylori, compared with those in duodenal ulcer patients with antral H. pylori. All of seven patients with both gastric metaplasia and H. pylori infection in the duodenum had duodenal ulcer, whereas only 1 of 14 patients without either gastric metaplasia or H. pylori infection in the duodenum had duodenal ulcer. There was normal or mild atrophic mucosa in the fundus of duodenal ulcer patients with H. pylori in the antrum, whereas moderate or severe atrophic mucosa in non-duodenal ulcer patients with H. pylori gastritis. These results suggest that the preserved fundic mucosa, gastric metaplasia in the duodenum, and a greater load of H. pylori to the duodenum through the gastric juice may be prerequisites for the formation of duodenal ulcers.
Saita
H
H
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
Murakami
M
M
Yoo
J K
JK
Teramura
S
S
Dekigai
H
H
Takahashi
Y
Y
Kita
T
T
D000328:Adult; D000375:Aging / Q000473:pathology; D001284:Atrophy; D004381:Duodenal Ulcer / Q000150:complications / Q000378:metabolism / Q000382:microbiology*; D004386:Duodenum / Q000382:microbiology; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000382:microbiology; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000150:complications / Q000378:metabolism / Q000382:microbiology*; D016481:Helicobacter Infections / Q000378:metabolism / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D013270:Stomach / Q000382:microbiology