ABO, Rh, MNSs, sex and typhoid fever.
A case-control study on the association between genetic markers (ABO, Rh, MNSs and sex) and typhoid fever (TF) was performed. We found that (a) the B allele conferred protection to females for TF and a mild susceptibility to males; (b) the CDe haplotype (or the RH3 phenotype, mostly CDe/CDe) was associated with protection against Salmonella in both sexes, while cDE (or RH7, mostly cDE/cDE, and RH8, mostly cDE/cde) was associated with susceptibility to TF, and (c) heterozygotes Ss (MNSs system) had a high susceptibility, while SS and particularly ss homozygotes seemed to be protected for the disease. There were very significant interactions among the blood systems and sex.
Valenzuela
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CY
Departamento de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Santiago.
Herrera
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P
D000017:ABO Blood-Group System / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002677:Chile; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics*; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000235:genetics*; D012727:Sex Characteristics; D014435:Typhoid Fever / Q000097:blood / Q000235:genetics*
D000017:ABO Blood-Group System; D005819:Genetic Markers; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System