title: Indomethacin and disodium etidronate for the prevention of recurrence of heterotopic ossification after surgical resection. Two case reports.
abstract: Two spinal cord injured patients had extensive heterotopic ossifications around their hips surgically removed. The use of disodium etidronate from 2 weeks presurgery to 2-5 months postsurgery and in particular indomethacin 25 mg twice daily, from 2 weeks prior to surgery to 6 weeks postsurgery may have helped to prevent recurrence of the ossifications in the follow up periods of 4 and 5 years respectively.
authors.affiliation: Centre for Spinal Cord Injured, Department TH, Rigshospitalet, Copenghagen, Denmark.
authors.forename: F
authors.initials: F
authors.lastname: Biering-Sørensen
authors.forename: E
authors.initials: E
authors.lastname: Tøndevold
mesh_terms: D000293:Adolescent; D000328:Adult; D012968:Etidronic Acid / Q000627:therapeutic use*; D006615:Hip / Q000601:surgery; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D009999:Ossification, Heterotopic / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery; D012008:Recurrence; D013119:Spinal Cord Injuries / Q000150:complications*
chemical_list: D012968:Etidronic Acid; D007213:Indomethacin