In vitro sensitivity of Plasmodium falciparum to drugs that bind DNA or inhibit its synthesis.
The in vitro sensitivity of Plasmodium falciparum to bleomycin, busulfan, camptothecin, CC-1065, cisplatin, daunomycin, distamycin, luzopeptin, mAMSA, mitomycin C, naladixic acid, U71184, VM26, and VP16, or combinations of them was examined. The lethal dose concentration for 50% of parasites for 3 compounds, luzopeptin, CC1065, and U71184, that bind to adenine-thymidine-rich nucleotide sequences, were in the range of 10(-11) M. They were at least 2 orders of magnitude more effective than the other compounds.
Lee
S
S
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755.
Inselburg
J
J
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000378:metabolism / Q000494:pharmacology*; D016054:DNA, Protozoan / Q000096:biosynthesis / Q000378:metabolism*; D000080890:Duocarmycins; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology; D007933:Leucomycins / Q000378:metabolism / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D011804:Quinolines / Q000378:metabolism / Q000494:pharmacology; D047630:Depsipeptides
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D016054:DNA, Protozoan; D000080890:Duocarmycins; D007211:Indoles; D007933:Leucomycins; D011804:Quinolines; C054483:U 71184; C018782:CC 1065; C029831:luzopeptins; D047630:Depsipeptides