Germ-line p53 mutation is uncommon in patients with triple primary cancers.
We examined five patients with multiple primary cancers who had a history of three different types of primary cancers for germ-line p53 mutations. The germ-line p53 mutation was detected in a patient who conformed to the Li-Fraumeni syndrome, but not in the other four patients. The diagnosis of these four patients did not fall in the category of Li-Fraumeni syndrome. This result indicates that germ-line p53 mutations are uncommon even in patients with triple primary cancers.
Shiseki
M
M
Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
Nishikawa
R
R
Yamamoto
H
H
Ochiai
A
A
Sugimura
H
H
Shitara
N
N
Sameshima
Y
Y
Mizoguchi
H
H
Sugimura
T
T
Yokota
J
J
D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*