Esophageal carcinoma in house musk shrews, Suncus murinus (Insectivora), induced by N-methyl-N'-nitro-N-nitrosoguanidine.
Female 6-week-old shrews were given a solution of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) at a concentration of 50 micrograms/ml or 100 micrograms/ml in the drinking water. All 11 shrews receiving 100 micrograms/ml MNNG died 8-13 days after the beginning of carcinogen administration and 6 of the 20 shrews receiving 50 micrograms/ml MNNG died after 10-54 days. When animals were between 43 and 54 weeks of age, multiple esophageal lesions were evoked in all 14 that had received 50 micrograms/ml MNNG for 30 weeks. All shrews developed a protruding, ulcerative, or superficial type of squamous-cell carcinoma of the esophagus, accompanied by papillomas. Local invasion was seen in squamous-cell carcinoma but no distant metastasis was noted. None of the 5 control shrews developed any esophageal abnormality. No gastric adenocarcinoma, intestinal sarcoma, or other tumors were induced with MNNG. It can be concluded that MNNG has a carcinogenic effect on shrew esophageal epithelium.
Tsubura
A
A
Department of Pathology, Kansai Medical University, Osaka, Japan.
Senzaki
H
H
Takahashi
H
H
Oyaizu
T
T
Morii
S
S
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D010212:Papilloma / Q000139:chemically induced* / Q000473:pathology; D012788:Shrews
D008769:Methylnitronitrosoguanidine