Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.
We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or concurrent with SEB but was less effective when administered following SEB injection. This observation indicates that IL-10 is capable of regulating T-cell activation in vivo.
Bean
A G
AG
Department of Immunology, DNAX Research Institute, Palo Alto, California 94304.
Freiberg
R A
RA
Andrade
S
S
Menon
S
S
Zlotnik
A
A
D000818:Animals; D004768:Enterotoxins / Q000633:toxicity*; D016753:Interleukin-10 / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012772:Shock, Septic / Q000628:therapy*; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000633:toxicity*; D013601:T-Lymphocytes / Q000276:immunology
D004768:Enterotoxins; D018089:Superantigens; D016753:Interleukin-10; C031818:enterotoxin B, staphylococcal