title: The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin.
abstract: The gastric pathogen Helicobacter pylori has been shown to produce a 19.6-kDa protein with apparent binding activity for erythrocytes, human buccal epithelial cells, and laminin. In this report we demonstrate that it is an iron-binding protein, resembling ferritin both structurally and biochemically. Also, because its binding activity for laminin, erythrocytes, and buccal cells was abolished by low concentrations of Tween 20, binding is likely nonspecific.
authors.affiliation: Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Doig
authors.forename: J W
authors.initials: JW
authors.lastname: Austin
authors.forename: T J
authors.initials: TJ
authors.lastname: Trust
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000302:isolation & purification / Q000378:metabolism* / Q000648:ultrastructure; D004848:Epithelium / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005293:Ferritins / Q000302:isolation & purification / Q000378:metabolism* / Q000648:ultrastructure; D016480:Helicobacter pylori / Q000378:metabolism*; D006736:Horses; D006801:Humans; D015151:Immunoblotting; D007797:Laminin / Q000378:metabolism; D008854:Microscopy, Electron; D008970:Molecular Weight; D009061:Mouth Mucosa / Q000378:metabolism; D013053:Spectrophotometry; D013154:Spleen / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D007797:Laminin; D005293:Ferritins