title: Target apex-seeking in factor analysis of medical image sequences.
abstract: The aim of factor analysis of medical image sequences (FAMIS) is to estimate a limited number of physical or physiological fundamental functions. Its oblique rotation stage strongly affects the quality and the interpretation of the resulting estimates (factors and factor images). A new target apex-seeking method which integrates physical or physiological knowledge in this stage is described. This knowledge concerns some of the fundamental functions and reacts on the determination of all the factors. A simulated spectral study illustrates the method. We discuss its properties in comparison with the other approaches using a priori physical or physiological information.
authors.affiliation: U66 INSERM, Institut Gustave Roussy, Villejuif, France.
authors.forename: I
authors.initials: I
authors.lastname: Buvat
authors.forename: H
authors.initials: H
authors.lastname: Benali
authors.forename: F
authors.initials: F
authors.lastname: Frouin
authors.forename: J P
authors.initials: JP
authors.lastname: Bazin
authors.forename: R
authors.initials: R
authors.lastname: Di Paola
mesh_terms: D003198:Computer Simulation; D005163:Factor Analysis, Statistical; D006801:Humans; D008961:Models, Structural; D011877:Radionuclide Imaging / Q000706:statistics & numerical data*