Tumor uptake of 99mTc-MIBI and 201Tl by a 9L gliosarcoma brain tumor model in rats.
There have been several recent case reports of the accumulation of 99mTc-MIBI [hexakismethoxyisobutylisonitriletechnetium(I), Cardiolite, Sestamibi] in tumors, but no reports of the uptake of this radiopharmaceutical in an animal model. To address this question, the biodistributions of 99mTc-MIBI and 201Tl were compared in Fisher rats bearing 9L gliosarcomas. The results showed that, although the absolute uptake of the tracers by the tumor is relatively low (< 1% ID/g), the tumor-to-normal brain ratios are greater than 6:1 because of low uptake by normal brain. The tumor-to-normal brain ratio of 99mTc-MIBI exceeds that of other currently available 99mTc radiopharmaceuticals suggesting that 99mTc-MIBI may be of particular value in the clinical evaluation of brain tumors and that further investigation of this class of compounds as tumor-avid radiopharmaceuticals is necessary.
Packard
A B
AB
Division of Nuclear Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115.
Kronauge
J F
JF
Limpa-Amara
N
N
Lampson
L
L
O'Tuama
L A
LA
Jones
A G
AG
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D018316:Gliosarcoma / Q000378:metabolism*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D017256:Technetium Tc 99m Sestamibi / Q000378:metabolism*; D013793:Thallium / Q000493:pharmacokinetics*; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D014018:Tissue Distribution
D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi; D013793:Thallium