title: The sequence of 5' flanking DNA from the rat preprotachykinin gene; analysis of putative transcription factor binding sites.
abstract: The rat preprotachykinin A (rPPT-A) gene is expressed in restricted populations of neurons and endocrine cells, including a subset of dorsal root ganglion (DRG) neurons. As part of a study to investigate the DNA sequences responsible for tissue-specific expression of the gene, we have determined the sequence of the 5' flanking DNA to 3350 bp upstream of the transcription start site. The sequenced region encodes a number of putative transcription factor binding sites which may play important roles in the regulation of rPPT-A gene transcription.
authors.affiliation: MRC Brain Metabolism Unit, Royal Edinburgh Hospital, UK.
authors.forename: K
authors.initials: K
authors.lastname: Chapman
authors.forename: V
authors.initials: V
authors.lastname: Lyons
authors.forename: A J
authors.initials: AJ
authors.lastname: Harmar
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics*; D051381:Rats / Q000235:genetics*; D015320:Tachykinins / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D011498:Protein Precursors; D015320:Tachykinins; D014157:Transcription Factors; C044206:preprotachykinin