title: Long-lasting decrease in dopamine uptake sites following repeated administration of methamphetamine in the rat striatum.
abstract: We investigated the effects of repeated administration of methamphetamine on dopamine (DA) uptake sites in the rat striatum by using an increasing dose paradigm of methamphetamine (2.5 mg/kg on day 1; 5 on day 3; 7.5 on day 5 and 10 on day 7), each being given twice on the indicated day by s.c. injection. It has been established that this administration paradigm produces distinct sensitization in methamphetamine-induced behavior. A 36% reduction in specific [3H]DA uptake, and a 29% reduction in specific [3H]GBR12935 binding in the striatum were demonstrated in rats sacrificed 7 days after the last methamphetamine administration. A similar reduction in striatal [3H]GBR12935 binding sites was observed even 30 days after discontinuation of the drug. These data indicate that this treatment regimen of gradually escalating doses of methamphetamine induces a long-lasting decrease of DA uptake sites in rat striatum.
authors.affiliation: Department of Psychiatry and Neurology, Hokkaido University, School of Medicine, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Koyama
authors.forename: I
authors.initials: I
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists; D066298:In Vitro Techniques; D007279:Injections, Subcutaneous; D007700:Kinetics; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D010879:Piperazines / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
chemical_list: D018492:Dopamine Antagonists; D010879:Piperazines; D008694:Methamphetamine; C044630:1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine; D004298:Dopamine