title: Combined effects of solvents on the rat's auditory system: styrene and trichloroethylene.
abstract: Because exposures to toxic agents typically involve more than one substance, it is necessary to know if combined exposures pose different risks than those to single agents. Many solvents have been implicated in central nervous disorders and some of them are known to produce hearing loss, probably mediated by damage to cochlear hair cells. Hearing loss was studied by recording the brainstem auditory evoked response (BAER) in male Long Evans rats exposed 8 h/day for 5 days to mixtures of styrene (STY) and trichloroethylene (TCE). Dose groups included air or solvent pairs (STY/TCE) in the following concentrations (ppm): (0:3000), (250:2250), (500:1500), (750:750) and (1000:0). Decreased BAER amplitude, indicative of hearing loss, was correlated with blood levels of total solvent. The effects were as predicted by a linear dose-addition model, indicating neither synergistic nor antagonistic interactions at the concentrations studied.
authors.affiliation: Neuroscience Department, SRI International, Menlo Park, CA 94025.
authors.forename: C S
authors.initials: CS
authors.lastname: Rebert
authors.forename: W K
authors.initials: WK
authors.lastname: Boyes
authors.forename: G T
authors.initials: GT
authors.lastname: Pryor
authors.forename: D J
authors.initials: DJ
authors.lastname: Svensgaard
authors.forename: K M
authors.initials: KM
authors.lastname: Kassay
authors.forename: G R
authors.initials: GR
authors.lastname: Gordon
authors.forename: N
authors.initials: N
authors.lastname: Shinsky
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D001306:Auditory Pathways / Q000187:drug effects*; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D004347:Drug Interactions; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D011930:Reaction Time / Q000502:physiology; D012044:Regression Analysis; D012997:Solvents / Q000633:toxicity*; D020058:Styrene; D013343:Styrenes / Q000097:blood / Q000633:toxicity*; D014241:Trichloroethylene / Q000097:blood / Q000633:toxicity*
chemical_list: D012997:Solvents; D013343:Styrenes; D014241:Trichloroethylene; D020058:Styrene