Reversible cardiopathy after accidental overdose of mitoxantrone.
Mitoxantrone is an anthraquinone structurally related to the anthracycline drugs doxorubicin and daunorubicin. In animal tumor models, it was equally cytotoxic as but less cardiotoxic than the parent compounds. We here describe the clinical course of a 9-year old girl who inadvertently received 100 mg/m2 of mitoxantrone as a bolus injection. Hemoperfusion carried out twice with the objective of increasing the drug clearance was totally inefficient. Severe but transient myelotoxicity was induced. Sequential echocardiograms demonstrated a reversible decrease of the shortening fraction of the left ventricle.
Hachimi-Idrissi
S
S
Department of Pediatrics, Vrije Universiteit, Brussels, Belgium.
Schots
R
R
DeWolf
D
D
Van Belle
S J
SJ
Otten
J
J
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D003561:Cytarabine / Q000008:administration & dosage; D004452:Echocardiography; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008508:Medication Errors; D008942:Mitoxantrone / Q000008:administration & dosage / Q000633:toxicity*; D013599:Systole / Q000187:drug effects
D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone