title: Dose modification factors in boron neutron capture therapy.
abstract: The effective treatment depth and therapeutic ratio in boron neutron capture therapy (BNCT) depend on a number of macroscopic dose factors such as boron concentrations in the tumor, normal tissue and blood. However, the role of various microscopic dose modification factors can be of critical importance in the evaluation of normal tissue tolerance levels. An understanding of these factors is valuable in designing BNCT experiments and the selection of appropriate boron compounds. These factors are defined in this paper and applied to the case of brain tumors with particular attention to capillary endothelial cells and oligodendrocytes.
authors.affiliation: Australien Nuclear Science & Technology Organization (ANSTO), Menai.
authors.forename: B J
authors.initials: BJ
authors.lastname: Allen
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000379:methods*; D006801:Humans; D011879:Radiotherapy Dosage