title: Möbius syndrome in infant exposed to cocaine in utero.
abstract: The pathophysiology of Möbius syndrome has been debated for decades. A vascular etiology is currently favored because it explains the wide clinical spectrum of this syndrome. An infant is reported who was born with Möbius syndrome after a pregnancy complicated by heavy maternal use of cocaine and alcohol. We speculate that cocaine-induced vasoconstriction at a critical time of cerebrovascular development produced a vascular disruption sequence leading to the Möbius syndrome.
authors.affiliation: Department of Neurology, University of North Carolina School of Medicine, Chapel Hill 27599-7025.
authors.forename: P
authors.initials: P
authors.lastname: Kankirawatana
authors.forename: M B
authors.initials: MB
authors.lastname: Tennison
authors.forename: O
authors.initials: O
authors.lastname: D'Cruz
authors.forename: R S
authors.initials: RS
authors.lastname: Greenwood
mesh_terms: D000328:Adult; D003042:Cocaine / Q000009:adverse effects*; D005158:Facial Paralysis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013577:Syndrome
chemical_list: D003042:Cocaine