Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.
The genes encoding three different human somatostatin receptor subtypes, designated SSTR1, SSTR2, and SSTR3, were mapped to chromosomes 14, 17, and 22, respectively, by analyzing their segregation in a panel of reduced human-hamster somatic cell hybrids. These assignments were confirmed independently using fluorescence in situ hybridization to metaphase chromosomes and the genes were further localized to 14q13, 17q24, and 22q13.1, respectively. Highly informative simple tandem repeat DNA polymorphisms were identified in SSTR1 and SSTR2.
Yamada
Y
Y
Howard Hughes Medical Institute, University of Chicago, Illinois 60637.
Stoffel
M
M
Espinosa
R
R
Xiang
K S
KS
Seino
M
M
Seino
S
S
Le Beau
M M
MM
Bell
G I
GI
D001483:Base Sequence; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D004277:DNA, Single-Stranded; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D017481:Receptors, Somatostatin / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
D004277:DNA, Single-Stranded; D017481:Receptors, Somatostatin