title: Factors predictive of sustained growth in children after renal transplantation. The North American Pediatric Renal Transplant Cooperative Study.
abstract: To ascertain growth and rehabilitation of children after transplantation, the North American Pediatric Renal Transplant Cooperative Study collected growth data on renal transplant recipients. From January 1987 through December 1990, a total of 1553 children with one or more transplants were entered into the study by its 75 participating centers. Of these, the first 300 children with a functioning graft and 2 years of linear growth data form the cohort for this study. For the total cohort of 300 patients, the mean (+/- SEM) baseline height z score was -2.41 +/- 0.09, and the change in z score determined after 2 years was 0.18 +/- 0.06 (p < 0.01). Children in the age group from birth to 1 year had the maximal deficit and had the maximal improvement in z score, gaining about 1 SD (p < 0.01). For the 2- to 5-year-old group, the change in z score was about 0.5 SD (p < 0.001). No improvement in z score was noted for children 6 to 17 years of age. Each increase in serum creatinine concentration of 90 mumol/L (1 mg/dl) was associated with -0.17 decrease in the z score (p < 0.001). Gender, donor source, history of previous transplantation, and prior dialysis were not associated with a significant change in the z score; thus the increased rate of growth during the first 2 post-transplantation years occurred mainly in subjects less than 6 years of age.
authors.affiliation: Department of Pediatrics, State University of New York Health Science Center, Brooklyn 11203.
authors.forename: A
authors.initials: A
authors.lastname: Tejani
authors.forename: R
authors.initials: R
authors.lastname: Fine
authors.forename: S
authors.initials: S
authors.lastname: Alexander
authors.forename: W
authors.initials: W
authors.lastname: Harmon
authors.forename: D
authors.initials: D
authors.lastname: Stablein
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection; D006128:Growth / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000502:physiology* / Q000534:rehabilitation; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D012044:Regression Analysis; D012189:Retrospective Studies; D014019:Tissue Donors
chemical_list: D003404:Creatinine; D011241:Prednisone