title: Elevated serum aminotransferase activity as an early manifestation of gluten-sensitive enteropathy.
abstract: Six children in whom long-standing hypertransaminasemia of unknown cause led to an initial diagnosis of chronic or protracted cryptogenic hepatitis were found to have asymptomatic celiac disease. Administration of a gluten-free diet caused a prompt improvement of both hepatic and intestinal biochemical/histologic abnormalities. Hepatic damage may be another "atypical" form of celiac disease in children.
authors.affiliation: Department of Pediatrics, Pediatric Gastroenterology and Hepatology, II Faculty of Medicine, University of Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Vajro
authors.forename: A
authors.initials: A
authors.lastname: Fontanella
authors.forename: M
authors.initials: M
authors.lastname: Mayer
authors.forename: A
authors.initials: A
authors.lastname: De Vincenzo
authors.forename: L M
authors.initials: LM
authors.lastname: Terracciano
authors.forename: M
authors.initials: M
authors.lastname: D'Armiento
authors.forename: R
authors.initials: R
authors.lastname: Vecchione
mesh_terms: D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005983:Glutens; D006521:Hepatitis, Chronic / Q000209:etiology / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D000637:Transaminases / Q000097:blood*
chemical_list: D005983:Glutens; D000637:Transaminases