title: Hydrometrocolpos following prenatal dexamethasone treatment for congenital adrenal hyperplasia (21-hydroxylase deficiency).
abstract: A female with congenital adrenal hyperplasia (21-hydroxylase deficiency) received prenatal dexamethasone treatment. Suppression of the fetal adrenal was initially inadequate but adequate in later pregnancy. The baby showed masculinisation without clitoral enlargement and a narrow urogenital sinus with resulting hydrometrocolpos. It is possible that dexamethasone treatment which is initially inadequate increases the risk of this latter complication.
authors.affiliation: Department of Endocrinology and Diabetes, Royal Children's Hospital (RCH), Melbourne, Australia.
authors.forename: J J
authors.initials: JJ
authors.lastname: Couper
authors.forename: J M
authors.initials: JM
authors.lastname: Hutson
authors.forename: G L
authors.initials: GL
authors.lastname: Warne
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011295:Prenatal Care; D014522:Urethral Diseases / Q000209:etiology; D014524:Urethral Obstruction / Q000209:etiology; D014548:Urinary Fistula / Q000209:etiology; D014591:Uterine Diseases / Q000209:etiology*; D014621:Vagina; D014623:Vaginal Diseases / Q000209:etiology*; D014624:Vaginal Fistula / Q000209:etiology
chemical_list: D003907:Dexamethasone