title: The cellular mechanism of ossicular erosion in chronic suppurative otitis media.
abstract: This is the first report of the application of a new examination technique for the assessment of cellular activity during bone resorption in chronic suppurative otitis media (CSOM). A total of nineteen includes removed during the course of tympanomastoid surgery were studied (retraction pocket: 2; tubo-tympanic CSOM: 4; attico-antral CSOM: 13). The microscopic surface topography of each specimen was examined using the scanning electron microscopy (SEM), and the appearances are interpreted in terms of cortical cellular activity. The results suggest that the mechanism of ossicular erosion in CSOM is similar regardless of the exact type of disease. Extensively pitted areas were seen in all specimens. These pits are morphologically indistinguishable from those characteristic of osteoclastic activity (Howship's lacunae). We conclude that in all causes the surface topography of eroded incudes is consistent with the activity of osteoclasts.
authors.affiliation: Department of Otoloryngology, General Infirmary, Leeds.
authors.forename: F J
authors.initials: FJ
authors.lastname: Lannigan
authors.forename: P
authors.initials: P
authors.lastname: O'Higgins
authors.forename: P
authors.initials: P
authors.lastname: Mcphie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004429:Ear Ossicles / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010035:Otitis Media, Suppurative / Q000473:pathology*