Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization.
The cell cycle control genes are highly conserved during evolution since they play a key role in the regulation of cell division. We have localized CDC25C and WEE1 respectively at 5q31 and 11p15.3-11p15.1 using fluorescent in situ hybridization of cDNA probes on human chromosomes. This shows that genes acting through a regulatory phosphorylation cascade are not clustered on the same chromosome. Furthermore, they appear to map on chromosomal regions involved in tumorigenesis. The 5q23-q31 region of chromosome 5 is deleted in some hematologic disorders, and the p15 region of chromosome 11 is involved in development of embryonic tumors.
Taviaux
S A
SA
CRBM-CNRS, Montpellier, France.
Demaille
J G
JG
D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D004247:DNA; D015342:DNA Probes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009687:Nuclear Proteins; D011494:Protein Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D011506:Proteins / Q000235:genetics*; D020687:cdc25 Phosphatases
D018797:Cell Cycle Proteins; D015342:DNA Probes; D009687:Nuclear Proteins; D011506:Proteins; D004247:DNA; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases; C499349:WEE1 protein, human; D020687:cdc25 Phosphatases