The synthesis of IL-1 receptor antagonist (IL-1ra) by synovial fibroblasts is markedly increased by the cytokines TNF-alpha and IL-1.
The regulation of inhibitors which block the action of IL-1 has significant implications in the control of inflammation. Different modulators of cellular metabolism were studied for their effect on the synthesis of IL-1 receptor antagonist (IL-1ra). Among the different growth factors and cytokines studied, only the inflammatory mediators IL-1 and TNF-alpha and one growth factor, PDGF-BB, were found to significantly increase, in an additive manner, the synthesis and secretion of IL-1ra.
Martel-Pelletier
J
J
Rheumatic Disease Unit, Notre-Dame Hospital Research Center, Montreal, Québec, Canada.
McCollum
R
R
Pelletier
J P
JP
D002478:Cells, Cultured; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D012795:Sialoglycoproteins / Q000096:biosynthesis*; D013583:Synovial Membrane / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D010982:Platelet-Derived Growth Factor; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha