title: Troponin T for the differential diagnosis of ischaemic myocardial damage.
abstract: The diagnostic performance of a new enzyme linked immunosorbent assay for the cardiac structural protein troponin T in the differential diagnosis of ischaemic cardiac damage was assessed. A well documented set of patients admitted to the coronary care unit of a district general hospital were studied. At a cutoff value of 0.2 micrograms/L, troponin T measurements 12-24 h after admission or 12-16 to 24-48 h from onset of chest pain showed an overall efficiency of 97.6% for diagnosis of proven myocardial infarction. Troponin T was not detectable in patients when ischaemic heart disease could be excluded but was present in four patients with angina. Detectable troponin T in these angina patients was associated with subsequent cardiac events.
authors.affiliation: Department of Clinical Biochemistry, West Middlesex University Hospital, UK.
authors.forename: P O
authors.initials: PO
authors.lastname: Collinson
authors.forename: D
authors.initials: D
authors.lastname: Moseley
authors.forename: P J
authors.initials: PJ
authors.lastname: Stubbs
authors.forename: G D
authors.initials: GD
authors.lastname: Carter
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis; D003325:Coronary Care Units; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D014336:Troponin / Q000097:blood*; D020107:Troponin T
chemical_list: D007527:Isoenzymes; D014336:Troponin; D020107:Troponin T; D003402:Creatine Kinase