title: Effects of interleukin-8 on nonspecific resistance to infection in neutropenic and normal mice.
abstract: The effect of treatment with interleukin-8 (IL-8), a neutrophil-activating cytokine, was investigated in normal and neutropenic mice infected with a lethal dose of Pseudomonas aeruginosa, Klebsiella pneumoniae, or Plasmodium berghei. Intraperitoneal (i.p.) IL-8 treatment was associated with accelerated death when IL-8 was administered shortly before i.p. infection with P. aeruginosa or shortly after i.p. infection with P. aeruginosa and K. pneumoniae. Histopathological analyses demonstrated a tendency to more severe organ lesions in IL-8-treated mice. Only nonneutropenic mice that received IL-8 shortly before the infectious challenge and at the site of infection were protected by IL-8. Whether IL-8 is protective of or detrimental to the survival of infection appeared to depend on the presence of bacteria at the injection site and on the presence of neutropenia. IL-8 may be an important participant in the cascade of interacting cytokines that is induced by the lethal infectious challenge.
authors.affiliation: Department of Medicine, University Hospital, Nijmegen, The Netherlands.
authors.forename: M T
authors.initials: MT
authors.lastname: Vogels
authors.forename: I J
authors.initials: IJ
authors.lastname: Lindley
authors.forename: J H
authors.initials: JH
authors.lastname: Curfs
authors.forename: W M
authors.initials: WM
authors.lastname: Eling
authors.forename: J W
authors.initials: JW
authors.lastname: van der Meer
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D001921:Brain / Q000382:microbiology / Q000473:pathology; D005260:Female; D016209:Interleukin-8 / Q000494:pharmacology*; D007710:Klebsiella Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D007711:Klebsiella pneumoniae; D007958:Leukocyte Count; D008288:Malaria / Q000276:immunology; D051379:Mice; D009503:Neutropenia / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D010962:Plasmodium berghei; D011552:Pseudomonas Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control
chemical_list: D016209:Interleukin-8