title: Demonstration of a relation between urinary digoxin-like immunoreactive substance and cardiac performance.
abstract: OBJECTIVE
  To determine the relation between urinary digoxin-like immunoreactive substance (DLIS) and cardiac performance.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Echocardiography laboratory of a university-affiliated teaching hospital.
  
  
  METHODS
  Thirty-four individuals referred for echocardiographic studies who had never received cardiac glycosides or other substances known to cross-react with a digoxin radioimmunoassay and had no condition that has been associated with increased DLIS.
  
  
  METHODS
  Cardiac dimensions and indices of cardiac performance derived from echocardiograms and cardiac Doppler flow studies and concentrations of urinary DLIS, creatinine, and electrolytes.
  
  
  RESULTS
  Urinary DLIS ranged from < 0.125 ng (digoxin equivalents) per milliliter (below the sensitivity of the assay) to 0.99 ng/ml, averaging 0.22 +/- 0.24 ng/ml. On bivariate analyses, UDLIS was found to correlate significantly with body weight, left ventricular (LV) end-diastolic dimension, LV fractional shortening, mitral transvalvular flow velocity following atrial systole, and urinary calcium. On multivariate analyses, the association between urinary DLIS (alone or adjusted for urinary creatinine) and LV fractional shortening emerged as the paramount independent relation.
  
  
  CONCLUSIONS
  Urinary DLIS can be related to cardiac performance under steady-state conditions. This suggests that DLIS may be a ligand for a cardiac glycoside receptor.
authors.affiliation: Section of Cardiology, Brooklyn Hospital Center.
authors.forename: H S
authors.initials: HS
authors.lastname: Friedman
authors.forename: B
authors.initials: B
authors.lastname: Babb
authors.forename: I B
authors.initials: IB
authors.lastname: Shim
authors.forename: G
authors.initials: G
authors.lastname: Sotomora
authors.forename: S M
authors.initials: SM
authors.lastname: Farrer
authors.forename: B C
authors.initials: BC
authors.lastname: Vasavada
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000652:urine*; D002298:Cardenolides; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000652:urine; D003404:Creatinine / Q000652:urine; D004077:Digoxin; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011863:Radioimmunoassay; D012044:Regression Analysis; D012503:Saponins
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D003404:Creatinine