title: Intrathecal baclofen in severe spasticity.
abstract: Control of severe spasticity and its associated features with administration of baclofen directly into the CSF via an intrathecal pump has radically improved the management of patients resistant to oral therapy. This article reviews the rationale and clinical indications for this technique, and the outcome and complications encountered.
authors.affiliation: Royal Cornwall Hospital, Treliske, Truro.
authors.forename: B N
authors.initials: BN
authors.lastname: McLean
mesh_terms: D001418:Baclofen / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D002985:Clinical Protocols / Q000592:standards; D002986:Clinical Trials as Topic; D004599:Electric Stimulation Therapy / Q000379:methods; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D009128:Muscle Spasticity / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D009407:Nerve Block / Q000379:methods; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D001418:Baclofen