Gangliosides facilitate the recovery of behavioral response mediated by dopaminergic sites following their irreversible blockade.
The effect of acute and chronic exogenous ganglioside (G) administration on the functional recovery of dopaminergic receptors following their blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was investigated by means of apomorphine (APO)-induced stereotyped behavior. Animals previously treated with EEDQ exhibited a lack of behavioral response to APO 6 or 24 h later. A progressive behavioral recovery was already evident at day 3 and reached control values at day 7. G pretreatment accelerated the behavioral recovery after EEDQ administration, because a higher behavioral response to APO in these animals as compared with rats treated with EEDQ alone at the same time was observed. These findings indicate that G accelerates the functional recovery of dopaminergic sites following their irreversible blockade.
Keller
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EA
Departamento de Farmacología, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba, Argentina.
Molina
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VA
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D018492:Dopamine Antagonists; D005732:Gangliosides / Q000494:pharmacology*; D008297:Male; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology
D018492:Dopamine Antagonists; D005732:Gangliosides; D011804:Quinolines; D011954:Receptors, Dopamine; C000470:EEDQ; D001058:Apomorphine