title: HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis.
abstract: Two unrelated young males with the unusual simultaneous presence of insulin-dependent diabetes mellitus, ulcerative colitis and primary sclerosing cholangitis are reported. Both patients manifested homozygosity for the DR3-DQw2 (DQB*0201) HLA genotypes. We believe that homozygosity for this genotype may predispose for this type of multi-organ autoimmune disease.
authors.affiliation: Department of Paediatrics, University of Lund, Malmö General Hospital, Sweden.
authors.forename: S A
authors.initials: SA
authors.lastname: Ivarsson
authors.forename: S
authors.initials: S
authors.lastname: Eriksson
authors.forename: I
authors.initials: I
authors.lastname: Kockum
authors.forename: A
authors.initials: A
authors.lastname: Lernmark
authors.forename: S
authors.initials: S
authors.lastname: Lindgren
authors.forename: K O
authors.initials: KO
authors.lastname: Nilsson
authors.forename: G
authors.initials: G
authors.lastname: Sundkvist
authors.forename: R
authors.initials: R
authors.lastname: Wassmuth
mesh_terms: D000293:Adolescent; D002648:Child; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male
chemical_list: D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D015803:HLA-DR3 Antigen