Effects of partial plasma exchange transfusion on blood flow velocity in large arteries of arm and leg, and in cerebral arteries in polycythaemic newborn infants.
Continuous wave Doppler velocimetry was performed in brachial, femoral and cerebral arteries in four preterm, four small-for-gestational-age (SGA) and eight appropriate-for-gestational age (AGA) polycythaemic newborns before and at 3 and 24 h after partial plasma exchange transfusion and in 18 matched controls at 3 and 24 h after birth. In peripheral arteries, end-diastolic flow velocity was zero in all eight AGA controls, but only in two of the other infants. Consequently, mean flow velocity and red cell transport in AGA controls were significantly lower than in the other five groups, which did not differ. Partial plasma exchange transfusion did not influence flow velocities and red cell transport in peripheral arteries, but normalized the flow velocities in cerebral arteries in all three subgroups of polycythaemic infants, which were lower than in control infants. Cerebral red cell transport in controls increased significantly between 3 and 24 h, and in polycythaemic infants between 0 and 3 h after partial plasma exchange transfusion. In conclusion, reduction in haematocrit had different effects on blood flow velocity and red cell transport of peripheral and cerebral vessels, suggesting that the increased cerebral blood flow velocity after partial plasma exchange transfusion is not simply due to a reduction in viscosity or oxygen content of the blood. The lower peripheral blood flow velocities in normocythaemic AGA infants as compared to all other groups, suggest that the level of maturity is an important determinant for the capacity to regulate blood flow.
Maertzdorf
W J
WJ
Department of Neonatology, University of Limburg, Maastricht, The Netherlands.
Tangelder
G J
GJ
Slaaf
D W
DW
Blanco
C E
CE
D000367:Age Factors; D001132:Arm / Q000098:blood supply*; D001158:Arteries / Q000503:physiopathology; D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000503:physiopathology*; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology*; D007236:Infant, Small for Gestational Age; D007866:Leg / Q000098:blood supply*; D010951:Plasma Exchange; D011086:Polycythemia / Q000503:physiopathology*; D012039:Regional Blood Flow