title: Chromosomal localization of the human ciliary neurotrophic factor gene (CNTF) to 11q12 by fluorescence in situ hybridization.
abstract: The human gene for ciliary neurotrophic factor (CNTF) was previously assigned to chromosome 11 by analysis of a panel of somatic cell hybrids. We isolated cosmid clones containing the CNTF gene from an arrayed-chromosome specific library and used fluorescent in situ hybridization to regionally localize the human CNTF gene on chromosome 11. The gene maps at an FLpter of 0.46, corresponding to a cytogenetic band position of 11q12.2.
authors.affiliation: Molecular Genetics Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138-9216.
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
authors.forename: A J
authors.initials: AJ
authors.lastname: Romo
authors.forename: G A
authors.initials: GA
authors.lastname: Evans
mesh_terms: D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D020934:Ciliary Neurotrophic Factor; D003001:Cloning, Molecular; D003360:Cosmids; D004247:DNA / Q000032:analysis; D015723:Gene Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction
chemical_list: D020934:Ciliary Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D004247:DNA