title: Betacellulin: a mitogen from pancreatic beta cell tumors.
abstract: Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
authors.affiliation: Department of Surgery, Children's Hospital, Boston, MA.
authors.forename: Y
authors.initials: Y
authors.lastname: Shing
authors.forename: G
authors.initials: G
authors.lastname: Christofori
authors.forename: D
authors.initials: D
authors.lastname: Hanahan
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: R
authors.initials: R
authors.lastname: Sasada
authors.forename: K
authors.initials: K
authors.lastname: Igarashi
authors.forename: J
authors.initials: J
authors.lastname: Folkman
mesh_terms: D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D066259:Betacellulin; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism; D006133:Growth Substances / Q000235:genetics* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007515:Islets of Langerhans / Q000503:physiopathology; D007700:Kinetics; D051379:Mice; D008969:Molecular Sequence Data; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D009838:Oligodeoxyribonucleotides; D010190:Pancreatic Neoplasms / Q000503:physiopathology*; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000187:drug effects; D016133:Polymerase Chain Reaction / Q000379:methods; D011498:Protein Precursors / Q000235:genetics; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid; D013936:Thymidine / Q000378:metabolism; D016211:Transforming Growth Factor alpha / Q000235:genetics
chemical_list: C587851:BTC protein, human; D066259:Betacellulin; C587852:Btc protein, mouse; C587853:Btc protein, rat; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D009838:Oligodeoxyribonucleotides; D011498:Protein Precursors; D011994:Recombinant Proteins; D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D013936:Thymidine