[The effect of Ryanodine for the myocardial protection in the working heart model of rabbit].
The purpose of this paper is to evaluate the effects of Ryanodine for myocardial protection. Twenty-four rabbits were studied using the working heart model divided four groups. The first is control group with no Ryanodine, the second is 10(-9) M, the third is 10(-8) M and the last one is 10(-7) M Ryanodine with GIK cardioplegic solution respectively. The hemodynamics was studied and the elemental concentrations (Ca, Mg, K, Na, Cl) of myocardial cell was measured using X-ray microanalysis. The results showed that intracellular Ca accumulation was dose-dependently suppressed with Ryanodine during reperfusion and also Ryanodine was significantly effective to maintain the hemodynamics during same one.
Morita
M
M
Department of Thoracic Surgery, Osaka Medical College, Takatsuki, Japan.
Sakai
Y
Y
Hikita
Y
Y
Sawada
Y
Y
Minohara
S
S
Oku
T
T
Sasaki
S
S
Takeuchi
A
A
Nakagaki
I
I
Sasaki
S
S
D000818:Animals; D004573:Electrolytes / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D006324:Heart Arrest, Induced; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008297:Male; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D012433:Ryanodine / Q000494:pharmacology*
D004573:Electrolytes; D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D012433:Ryanodine; D005947:Glucose; D011188:Potassium