Effects of six months' white spirit inhalation exposure in adult and old rats.
In two separate experiments in rats the irreversible effects of six months' exposure to white spirit (0, 400 p.p.m., and 800 p.p.m.) were studied. In one experiment the exposure started at the age of three months, in the other the rats were 15 months at the beginning of the exposure. After an exposure-free period of several months neurobehavioural, pathological, and neurochemical examinations were performed. A marked difference in motor activity between young and aged animals was found. A slight effect on kidney function was seen at 800 p.p.m. No macroscopic or histopathological changes related to dosing were found. The concentrations of noradrenaline, dopamine, and 5-hydroxytryptamine in various brain regions and in whole brain were irreversibly changed. In conclusion, the study revealed different changes within the CNS, but failed to demonstrate neurobehavioural white spirit-induced neurotoxicity.
Ostergaard
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Institute of Toxicology, National Food Agency, Søborg, Denmark.
Lam
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Ladefoged
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Arlien-Søborg
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D000280:Administration, Inhalation; D000375:Aging / Q000187:drug effects*; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D006838:Hydrocarbons / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012997:Solvents / Q000633:toxicity*
D006838:Hydrocarbons; D012997:Solvents; D012701:Serotonin; C013089:ligroin; D004298:Dopamine; D009638:Norepinephrine