title: LH-RH analogue treatment in adenocarcinoma of the pancreas: a phase II study. Gruppo Ligure per lo Studio del Pancreas.
abstract: In this phase II study, we treated 7 patients, all males, with stage III or IV pancreatic cancer with goserelin (an LH-RH analogue). Goserelin was administered at a dose of 3.6 mg every 4 weeks. The tumour response was assessed by measuring lesions with US- or CT-scan studies, according to WHO criteria. No response was observed. The median survival was 8 months in locally unresectable tumours and 4 months in advanced disease. The accrual was actually stopped at 7 cases because there were no responses in either of our series or in those published during our study. The authors conclude that the treatment with LH-RH analogue alone cannot be recommended for further studies.
authors.affiliation: Servizi di Gastroenterologia ed Endoscopia digestiva, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italia.
authors.forename: A
authors.initials: A
authors.lastname: Allegretti
authors.forename: R
authors.initials: R
authors.lastname: Lionetto
authors.forename: S
authors.initials: S
authors.lastname: Saccomanno
authors.forename: M
authors.initials: M
authors.lastname: Paganuzzi
authors.forename: M
authors.initials: M
authors.lastname: Onetto
authors.forename: C
authors.initials: C
authors.lastname: Martinoli
authors.forename: G
authors.initials: G
authors.lastname: Rollandi
authors.forename: M
authors.initials: M
authors.lastname: Marugo
authors.forename: L
authors.initials: L
authors.lastname: Fazzuoli
authors.forename: V
authors.initials: V
authors.lastname: Pugliese
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000368:Aged; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D017273:Goserelin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013739:Testosterone / Q000097:blood
chemical_list: D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone