title: Efficacy of semduramicin and salinomycin against different stages of Eimeria tenella and E. acervulina in the chicken.
abstract: The efficacy of a new ionophore, semduramicin, was compared with salinomycin in a series of in ovo and in vivo trials. Semduramicin was more efficacious than salinomycin against Eimeria tenella sporozoites as judged by oocyst production in embryonated eggs. When the two drugs were given in ovo at 93 h post inoculation (PI), both drugs exerted some effect against late schizogonous stages of E. tenella. In three battery studies, semduramicin (25 ppm) and salinomycin (60 and 66 ppm) were tested against E. tenella and E. acervulina. Medicated feed was withdrawn at 24-h intervals PI to study the stage of action of the anticoccidials. In E. tenella infected chickens, both anticoccidials exerted their maximum effect on weight gain and feed:gain ratio through the first 72 h PI. Semduramicin was more effective than salinomycin in controlling E. tenella lesions and coccidiosis mortality. With E. acervulina, both drugs acted similarly on early life cycle stages and no improvement in performance was recorded when medicated feed was given for longer than 72 h. Semduramicin was more effective than salinomycin in controlling E. acervulina lesions.
authors.affiliation: Animal Health Group, Pfizer Inc., New York, NY 10017.
authors.forename: D P
authors.initials: DP
authors.lastname: Conway
authors.forename: J K
authors.initials: JK
authors.lastname: Johnson
authors.forename: V
authors.initials: V
authors.lastname: Guyonnet
authors.forename: P L
authors.initials: PL
authors.lastname: Long
authors.forename: C D
authors.initials: CD
authors.lastname: Smothers
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002642:Chick Embryo; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D004539:Eimeria / Q000187:drug effects; D016786:Eimeria tenella / Q000187:drug effects; D007476:Ionophores / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009550:Nigericin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D011201:Poultry Diseases / Q000188:drug therapy*; D011714:Pyrans / Q000494:pharmacology / Q000627:therapeutic use; D000095662:Polyether Polyketides
chemical_list: D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D007476:Ionophores; D009550:Nigericin; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides; C072941:semduramicin