title: Evaluation of CT images, tumour response and prognosis after thermoradiotherapy for deep-seated tumours.
abstract: Thermoradiotherapy was applied for the treatment of deep-seated tumours in 41 patients. Low-density area (LDA) on CT images which appeared or expanded within the tumour after treatment was evaluated. Derived conclusions are as follows: (1) of 41 patients, LDA newly appeared or expanded in 24; (2) change of density was related closely with size of a tumour, histological characteristics of the tumour and heating condition; (3) histologically, LDA consisted of coagulation necrosis and tumour cells at the peripheral wall were highly degenerated; (4) a greater extent of LDA indicated the increasing possibility of local control; (5) probability of survival for patients with an increase of LDA was significantly superior to those without changes of LDA; (6) LDA may be a good landmark for judgement of the prognosis of a patient treated by thermoradiotherapy; and (7) new criteria of treatment effectiveness including density changes were proposed.
authors.affiliation: Department of Radiation Therapy, Tokyo Metropolitan Komagome Hospital, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takeshita
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy; D011379:Prognosis; D000078702:Radiofrequency Therapy; D011882:Radiotherapy, High-Energy; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy