title: A simulation study on a self-tuning portable controller of blood glucose.
abstract: A self-tuning, nonlinear controller was developed to drive portable or implantable micro-pumps for blood glucose control in diabetic subjects. The parameter estimation is based on a recursive least-square algorithm applied to a discrete time simplified mathematical model of the glucose system; the controller, which is integrated with the estimator, uses an extended minimum-variance method. The software was designed to drive a micro-controller wearable unit, operating with different kinds of glucose sensors, in order to perform chemical and biological experimentations. Some strategies were introduced to avoid hypoglycaemia, even tolerating a reduction in control speed and accuracy. The whole system was tested in a simulation study, performed on a mathematical model implemented on a personal computer. The tests were performed while simulating different controller structures and settings, and patient responses. They showed a satisfactory control behaviour, mostly as far as stability and robustness are concerned, in all simulated conditions.
authors.affiliation: Medical Pathology Institute, Bioengineering Laboratory, University of Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Brunetti
authors.forename: C
authors.initials: C
authors.lastname: Cobelli
authors.forename: P
authors.initials: P
authors.lastname: Cruciani
authors.forename: P G
authors.initials: PG
authors.lastname: Fabietti
authors.forename: F
authors.initials: F
authors.lastname: Filippucci
authors.forename: F
authors.initials: F
authors.lastname: Santeusanio
authors.forename: E
authors.initials: E
authors.lastname: Sarti
mesh_terms: D000465:Algorithms; D015190:Blood Glucose Self-Monitoring; D003198:Computer Simulation; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007332:Insulin Infusion Systems; D012984:Software