title: Ondansetron plus dexamethasone in the control of high dose cisplatin-induced emesis.
abstract: Twenty-two patients who underwent chemotherapy with cisplatin (CDDP) at doses > 100 mg/m2 also received antiemetic treatment comprised of the combination of ondansetron plus dexamethasone. The results obtained have shown a good activity from this combination with these high doses of CDDP, with a response of 81.8% (complete+major protection). There were also three therapeutic failures in patients with a few negative prognostic characteristics. It is our intention to use a benzodiazepine and adequate psychological support in an attempt to increase the response percentages in these kinds of patients.
authors.affiliation: Oncology Clinic, Università di Messina, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Maisano
authors.forename: G
authors.initials: G
authors.lastname: Toscano
authors.forename: V
authors.initials: V
authors.lastname: Adamo
authors.forename: G
authors.initials: G
authors.lastname: Altavilla
authors.forename: N
authors.initials: N
authors.lastname: Caristi
authors.forename: G
authors.initials: G
authors.lastname: Chiofalo
authors.forename: A
authors.initials: A
authors.lastname: Gnani
authors.forename: A
authors.initials: A
authors.lastname: Scimone
mesh_terms: D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy; D017294:Ondansetron / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D017294:Ondansetron; D003907:Dexamethasone; D002945:Cisplatin