Does TGF-beta protect articular cartilage in vivo?
Repeated intraarticular injections of transforming growth factor beta cause stimulation of articular cartilage proteoglycan synthesis, influx of inflammatory cells, fibrosis and osteophyte formation. When injected together with interleukin-1, TGF-beta enhances IL-1 induced cell-attraction in a synergistic way, while it counteracts IL-1 induced suppression of cartilage PG synthesis.
van Beuningen
H M
HM
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
van der Kraan
P M
PM
Arntz
O J
OJ
van den Berg
W B
WB
D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism / Q000473:pathology; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007267:Injections; D007375:Interleukin-1 / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D011509:Proteoglycans / Q000096:biosynthesis; D013431:Sulfates / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000494:pharmacology*
D007375:Interleukin-1; D011509:Proteoglycans; D013431:Sulfates; D016212:Transforming Growth Factor beta