title: Synergy of cefotaxime and fosfomycin against penicillin-resistant pneumococci.
abstract: The killing kinetics of cefotaxime and fosfomycin, alone and in combination, against seven clinical isolates of penicillin-resistant pneumococci were studied. The antibiotics were tested at 1 x, 2 x and 4 x the MIC for each individual isolate. The results showed a synergic interaction of the two antibiotics for three of the seven strains. This strategy may be useful clinically.
authors.affiliation: Laboratoire Central de Microbiologie, CHU Saint-Antoine, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Barakett
authors.forename: D
authors.initials: D
authors.lastname: Lesage
authors.forename: F
authors.initials: F
authors.lastname: Delisle
authors.forename: B
authors.initials: B
authors.lastname: Burghoffer
authors.forename: G
authors.initials: G
authors.lastname: Richard
authors.forename: P
authors.initials: P
authors.lastname: Vergez
authors.forename: J C
authors.initials: JC
authors.lastname: Petit
mesh_terms: D002439:Cefotaxime / Q000494:pharmacology*; D004357:Drug Synergism; D005578:Fosfomycin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D005578:Fosfomycin; D002439:Cefotaxime