title: Bilateral pyoderma gangrenosum of the hand: treatment with dapsone.
abstract: The first reported case of bilateral pyoderma gangrenosum of the hands is presented. One lesion was treated with wound care only, with spontaneous healing after two months. The contralateral lesion which occurred one month later was treated with wound care and oral dapsone. Healing occurred between four and six weeks after the start of dapsone. It is suggested that this acts by limiting the necrotizing process, thus allowing earlier epithelialization. Pyoderma gangrenosum is rare, and treatment is non-surgical. It is important that it is recognized to avoid extension of the necrotizing process through ill-advised surgery.
authors.affiliation: Division of Plastic Surgery, Southern Illinois University School of Medicine, Springfield.
authors.forename: R E
authors.initials: RE
authors.lastname: Brown
authors.forename: L
authors.initials: L
authors.lastname: Lay
authors.forename: D
authors.initials: D
authors.lastname: Graham
mesh_terms: D000368:Aged; D003622:Dapsone / Q000627:therapeutic use*; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011196:Potassium Permanganate / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000188:drug therapy*; D012837:Silver Sulfadiazine / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use; D014945:Wound Healing / Q000502:physiology
chemical_list: D011196:Potassium Permanganate; D014640:Vancomycin; D003622:Dapsone; D012837:Silver Sulfadiazine