[The glycolipid composition of Francisella tularensis strains with different degrees of attenuation].
The glycolipid composition of F. tularensis strains was investigated by silica gel thin-layer chromatography. Vaccine strains in contrast to virulent ones lacked glycolipid 8, possessed new glycolipid 8-a and a higher level of glycolipid 7. Low immunogenic strains had a decreased content of glycolipids, while avirulent non-immunogenic strain (15-a) nearly completely lost them. Thus, the glycolipid composition is associated with the level of attenuation, virulence and immunogenicity of F. tularensis.
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V V
VV
D001428:Bacterial Vaccines / Q000032:analysis*; D002855:Chromatography, Thin Layer; D005604:Francisella tularensis / Q000737:chemistry* / Q000276:immunology / Q000472:pathogenicity; D006017:Glycolipids / Q000032:analysis*; D014613:Vaccines, Attenuated / Q000032:analysis; D014774:Virulence
D001428:Bacterial Vaccines; D006017:Glycolipids; D014613:Vaccines, Attenuated