title: Acquired sideroblastic anaemia during treatment of Wilson's disease with triethylene tetramine dihydrochloride.
abstract: We report one case of acquired sideroblastic anaemia in a patient treated for Wilson's disease with triethylene tetramine dihydrochloride (TTH). No other cause of acquired sideroblastic anaemia was found, and neither iron nor pyridoxine therapy could correct this anaemia. In contrast, decreasing the dose of TTH led to disappearance of ringed sideroblasts. Thus TTH should be added as a further cause of secondary acquired sideroblastic anaemia. The pathophysiology of this finding, probably linked to an abnormality of mitochondrial iron metabolism, is briefly discussed.
authors.affiliation: Département de Pédiatrie, Centre Hospitalo-Universitaire de Bicêtre, France.
authors.forename: L
authors.initials: L
authors.lastname: Condamine
authors.forename: O
authors.initials: O
authors.lastname: Hermine
authors.forename: P
authors.initials: P
authors.lastname: Alvin
authors.forename: M
authors.initials: M
authors.lastname: Levine
authors.forename: C
authors.initials: C
authors.lastname: Rey
authors.forename: V
authors.initials: V
authors.lastname: Courtecuisse
mesh_terms: D000293:Adolescent; D000756:Anemia, Sideroblastic / Q000139:chemically induced*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D014266:Trientine / Q000009:adverse effects*
chemical_list: D014266:Trientine