title: Molecular evolution of a repetitive region within the per gene of Drosophila.
abstract: The clock gene period (per) controls a number of biological rhythms in Drosophila. In D. melanogaster, per has a repetitive region that encodes a number of alternating threonine-glycine residues. We sequenced and compared this region from several different Drosophila species belonging to various groups within the Drosophila and Sophophora subgenera. This part of per shows a great variability in both DNA sequence and length. Furthermore, analysis of the data suggests that changes in the length of this variable region might be associated with amino acid replacements in the more conserved flanking sequences.
authors.affiliation: Department of Genetics, University of Leicester, United Kingdom.
authors.forename: A A
authors.initials: AA
authors.lastname: Peixoto
authors.forename: S
authors.initials: S
authors.lastname: Campesan
authors.forename: R
authors.initials: R
authors.lastname: Costa
authors.forename: C P
authors.initials: CP
authors.lastname: Kyriacou
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001683:Biological Clocks / Q000235:genetics*; D005075:Biological Evolution; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000235:genetics*; D005796:Genes; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D004247:DNA