D-lactate metabolism in patients with chronic renal failure undergoing CAPD.
To clarify the D-lactate metabolism in patients with chronic renal failure undergoing CAPD, plasma levels, loaded doses and urinary excretion of D-lactate were measured. In addition, D-2-hydroxy acid dehydrogenase activities in resected and autopsied specimens were measured. The daily loaded dose of D-lactate by CAPD was 88.9 +/- 1.29 mmol and urinary excretion was negligible. There was no tendency for the plasma D-lactate to accumulate. The enzyme activity was detected in the liver, kidney and pancreas tissues both in the resected and autopsied specimens. The above findings indicate that the loaded D-lactate is catabolized in patients with chronic renal failure undergoing CAPD, and D-2-hydroxy acid dehydrogenase is responsible for the metabolism of D-lactate in humans.
Yasuda
T
T
First Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Ozawa
S
S
Shiba
C
C
Maeba
T
T
Kanazawa
T
T
Sugiyama
M
M
Owada
S
S
Ishida
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D015314:Dialysis Solutions; D005260:Female; D006801:Humans; D007668:Kidney / Q000201:enzymology; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy*; D007770:L-Lactate Dehydrogenase; D045022:Lactate Dehydrogenases; D007773:Lactates / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D019344:Lactic Acid; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology; D010531:Peritoneal Dialysis, Continuous Ambulatory
D015314:Dialysis Solutions; D007773:Lactates; D019344:Lactic Acid; D000429:Alcohol Oxidoreductases; D045022:Lactate Dehydrogenases; D007770:L-Lactate Dehydrogenase; C071195:D-lactate dehydrogenase; C021379:D-2-hydroxyacid dehydrogenase