title: [Combined posterior chamber intraocular lens implantation and trabeculectomy--a life-table analysis of postoperative clinical course].
abstract: Postoperative courses of 68 eyes of 58 glaucoma patients who underwent posterior chamber intraocular lens implantation combined with trabeculectomy were studied retrospectively. The visual acuity was 0.5 or better in 66% of the eyes at 3 months postoperatively. The average intraocular pressure (IOP) was below 15 mmHg till 16 months postoperatively. An analysis of the postoperative course using the life-table method of Kaplan-Meier revealed that the probability of successful IOP control with medication was 83% at 18 months and 47% without medication. The subjects aged 75 years or older showed significantly higher success probability than those younger than 75 years, while types of glaucoma, the preoperative IOP control, location of conjunctival or sclerocorneal incision, postoperative 5-fluorouracil (5-FU) injections or surgical intervention on the iris had no significant effects on the probability of successful IOP control. The probability of subsistence of functional filtering bleb was 24% at 18-month follow-up, on which postoperative administration of 5-FU of 35 mg or more had a favorable effect.
authors.affiliation: Eye Clinic, JR Tokyo General Hospital, Shibuya-ku, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamagami
authors.forename: M
authors.initials: M
authors.lastname: Araie
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Nagahara
authors.forename: S
authors.initials: S
authors.lastname: Shirato
authors.forename: J
authors.initials: J
authors.lastname: Yamagami
authors.forename: N
authors.initials: N
authors.lastname: Koseki
authors.forename: Y
authors.initials: Y
authors.lastname: Takenaka
authors.forename: F
authors.initials: F
authors.lastname: Kohda
mesh_terms: D000368:Aged; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D007910:Lenses, Intraocular / Q000401:mortality*; D015993:Life Tables; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014130:Trabeculectomy / Q000401:mortality*; D014785:Vision, Ocular / Q000502:physiology
chemical_list: D005472:Fluorouracil