Structure of the HLA class I region and expression of its resident genes.
The past year has seen several advances in the analysis of the HLA class I region and some of its resident genes. A description of the human class I gene family and the cloning of the class I region in yeast artificial chromosomes have provided two steps forward in the analysis of the class I region. Advances have been made in understanding the expression of the non-classical HLA class Ib genes and work with the murine class Ib proteins has demonstrated that these antigens can present a specialized subset of peptides to the immune system.
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Fred Hutchinson Cancer Research Center, Seattle, Washington.
D000818:Animals; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D051379:Mice
D006183:H-2 Antigens; D006680:HLA Antigens