title: Haemocompatibility of Ti6A14V alloy.
abstract: Ti6A14V alloy has been mainly used as a biomaterial in the orthopaedic field. The present study describes the surface state of the Ti6A14V material and evaluates its in vitro haemocompatibility in terms of protein adsorption, platelet retention and haemolysis. The behaviour of the Ti6A14V alloy towards albumin and fibrinogen was compared to that of a reference medical-grade elastomer. The platelet retention test gave better results than those achieved with the elastomer. The haemolysis percentage of the alloy was almost zero. These results indicate that the Ti6A14V alloy is well tolerated by blood.
authors.affiliation: INSERM U. 306, Université de Bordeaux II, France.
authors.forename: I
authors.initials: I
authors.lastname: Dion
authors.forename: C
authors.initials: C
authors.lastname: Baquey
authors.forename: J R
authors.initials: JR
authors.lastname: Monties
authors.forename: P
authors.initials: P
authors.lastname: Havlik
mesh_terms: D000327:Adsorption; D000497:Alloys; D001672:Biocompatible Materials / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D001798:Blood Proteins / Q000187:drug effects / Q000502:physiology*; D005340:Fibrinogen / Q000187:drug effects / Q000502:physiology; D006353:Heart-Assist Devices; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D012408:Rubber / Q000494:pharmacology; D012709:Serum Albumin / Q000187:drug effects / Q000502:physiology; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D001798:Blood Proteins; D012709:Serum Albumin; C031462:titanium alloy (TiAl6V4); D005340:Fibrinogen; D012408:Rubber; D014025:Titanium