Chronically instrumented rat model for hemodynamic studies of both pulmonary and systemic circulations.
We developed a chronic rat preparation in which a flow probe is placed around the ascending aorta and arterial catheters are implanted in the systemic and pulmonary circulations. This preparation was used to continuously monitor cardiac output (CO), systemic arterial pressure (Psa), and pulmonary arterial pressure (Ppa). More than 80% of the instrumented animals appeared healthy and continued to gain weight for longer than 2 wk. Stable CO, Psa, and Ppa were observed throughout this period. The effects of angiotensin II and hypoxia on the systemic and pulmonary circulations were studied, and possible adverse effects on the heart of long-term implantation of the flow probe were examined. This rat model provides a physiological small-animal preparation for short- and long-term hemodynamic and therapeutic studies on both the systemic and pulmonary circulations.
Sardella
G L
GL
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001.
Ou
L C
LC
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight; D002302:Cardiac Output / Q000502:physiology; D002404:Catheterization; D055590:Electromagnetic Phenomena; D005263:Femoral Artery / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D008954:Models, Biological; D009929:Organ Size / Q000502:physiology; D010827:Physiology / Q000295:instrumentation*; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000804:Angiotensin II