Anorectic effects of amylin in rats over the life span.
Amylin is a pancreatic peptide hormone that has been demonstrated to antagonize a number of the effects of insulin. This study demonstrated that amylin, when administered IP, decreased food intake in 4-month-old rats at doses of 50, 75, and 100 micrograms/kg. Amylin was slightly more potent at suppressing food intake at 13 months of age and less potent at decreasing food intake in 21- and 25-month-old rats, but the difference was not significant. These studies show that amylin is another peripheral anorectic peptide. They do not implicate amylin in the pathogenesis of the anorexia of aging.
Morley
J E
JE
Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO 63104.
Morley
P M
PM
Flood
J F
JF
D000375:Aging / Q000523:psychology; D000682:Amyloid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D007274:Injections, Intraperitoneal; D058228:Islet Amyloid Polypeptide; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D000682:Amyloid; D001067:Appetite Depressants; D058228:Islet Amyloid Polypeptide