Biology of lung cancer.
New treatments of lung cancer are likely to develop from a greater understanding of the biology of lung tumors and the mechanisms of carcinogenesis and tumor progression. It is clear that numerous molecular genetic changes are present in lung cancer. Some of these changes, eg, mutated oncogenes, are found in other tumors. They provide clues about the carcinogenesis and pathogenesis of lung cancer. The relationship between these genetic changes and prognosis is becoming clearer. Study of membrane receptors for growth signaling and interaction of cells with their environment has identified factors relevant to prognosis and possible targets for therapy. Model systems to interfere with growth signaling have been developed.
Ledermann
J A
JA
University College London Medical School, Middlesex Hospital, UK.
Souhami
R L
RL
D000951:Antigens, Neoplasm / Q000032:analysis; D004351:Drug Resistance; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D009363:Neoplasm Proteins / Q000032:analysis; D009857:Oncogenes; D011836:Radiation Tolerance
D000951:Antigens, Neoplasm; D006133:Growth Substances; D009363:Neoplasm Proteins