Histopathologic effects of extracorporeal shock wave lithotripsy on rabbit kidney.
Despite the widespread clinical use of the lithotriptor, the margin of safety for the kidney during shock wave application is substantially unknown. Although a series of pilot studies have been performed in laboratory animals, long-term follow-up is mandatory to establish the effect of extracorporeal shock wave lithotripsy (ESWL) and subsequent dose-dependent changes on the kidneys. An experimental study was performed in 45 rabbits; to define and compare the early and late complications of ESWL in the kidneys. The rabbits were divided into three groups of 15 animals each that received 1000, 1500 or 3000 shock waves respectively at 15-20 kV. The rabbits in each group were killed and necropsy performed within 24 h for the first 5 animals, 1 week for the second 5 animals and 2 months post-ESWL for the last 5 animals. Dose-dependent moderate damage (subcapsular hemorrhage, interstitial hemorrhage, capsular tension and perirenal hemorrhage) were noted in all kidneys at 24 h after treatment. Evidence of permanent changes (some fibrosis, tubular and glomerular damage, chronic inflammatory alterations) was noted in long-term follow up. Complete necrosis of the treated kidney was not encountered in this study.
Karalezli
G
G
Department of Urology, Ibn-i Sina Hospital, University of Ankara Medical School, Turkey.
Gögüş
O
O
Bedük
Y
Y
Köküuslu
C
C
Sarica
K
K
Kutsal
O
O
D000818:Animals; D001284:Atrophy / Q000473:pathology; D005069:Evaluation Studies as Topic; D005355:Fibrosis; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D007668:Kidney / Q000293:injuries* / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology; D008096:Lithotripsy / Q000009:adverse effects*; D009336:Necrosis; D009393:Nephritis / Q000209:etiology / Q000473:pathology; D011817:Rabbits; D012449:Safety; D013997:Time Factors