title: Absence of frontal somatosensory evoked potentials in Huntington's disease.
abstract: A fast route for transmission of deep and cutaneous afferent information to the frontal cortex is well established in non-human primates. Whether the incoming cortical information gives rise to early frontal somatosensory evoked potentials (SEPs) in humans is still a matter of contention. We attempted to solve this question by investigating the topography of SEP generators evoked by median nerve stimulation in 30 healthy subjects and in 30 patients suffering from Huntington's disease, who are known to have reduced SEP amplitudes. Using an earlobe reference, SEPs were recorded with an array of either five surface electrodes over the contralateral parietal cortex or 32 electrodes distributed over the whole scalp. In normal subjects analysis of frontal potentials revealed an early positive (P22) and negative (N30) component which could not be explained by generators located in the parietal cortex. Apart from the reduction of parietal components (N20, P25) frontal P22 and N30 were diminished or absent in Huntington's disease patients. Frontal potentials were even reduced in those patients who had parietal SEP amplitudes within the range of normal subjects. These frontal changes are similar to those reported in other basal ganglia disorders. Basal ganglia dysfunction might therefore be associated with changes of frontal SEP components.
authors.affiliation: Neurologische Klinik, Alfried Krupp Krankenhaus, Essen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Töpper
authors.forename: M
authors.initials: M
authors.lastname: Schwarz
authors.forename: K
authors.initials: K
authors.lastname: Podoll
authors.forename: F
authors.initials: F
authors.lastname: Dömges
authors.forename: J
authors.initials: J
authors.lastname: Noth
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000503:physiopathology; D011930:Reaction Time