Synovial copper deposition as a possible explanation of arthropathy in Wilson's disease.
A patient with longstanding Wilson's disease and arthritis is presented. Synovial biopsy disclosed thickening of the membrane, intimal histiocytes, and lymphocyte infiltration without pigmentation. X-ray energy spectroscopy demonstrated copper and iron in high concentrations. These findings may contribute to our understanding of the development of the arthropathy in patients with Wilson's disease.
Kramer
U
U
Department of Internal Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
Weinberger
A
A
Yarom
R
R
Zoldan
J
J
Bahar
A
A
Godoth
N
N
D001168:Arthritis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D001706:Biopsy; D003300:Copper / Q000737:chemistry*; D004577:Electron Probe Microanalysis; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia; D007249:Inflammation; D008875:Middle Aged; D011859:Radiography; D013052:Spectrometry, X-Ray Emission; D013583:Synovial Membrane / Q000737:chemistry* / Q000473:pathology
D003300:Copper