title: Mixed haplotypes and autoimmunity.
abstract: Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-E alpha dE beta z, and that this molecule plays a key role in the development of autoimmunity.
authors.affiliation: Beirne Carter Center, Health Sciences Center, University of Virginia, Charlottesville 22908.
authors.forename: N R
authors.initials: NR
authors.lastname: Nygard
authors.forename: D M
authors.initials: DM
authors.lastname: McCarthy
authors.forename: J
authors.initials: J
authors.lastname: Schiffenbauer
authors.forename: B D
authors.initials: BD
authors.lastname: Schwartz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D003433:Crosses, Genetic; D005091:Exons; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008181:Lupus Nephritis / Q000235:genetics / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics* / Q000276:immunology; D008957:Models, Genetic; D008969:Molecular Sequence Data
chemical_list: D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen