title: HLA antigens in anti-Ro(SS-A)-positive patients with recurrent annular erythema.
abstract: BACKGROUND
  Recurrent annular erythema associated with the anti-Ro(SS-A) antibody response has recently been reported in Orientals. The association is assumed to represent a distinct clinical entity.
  
  
  OBJECTIVE
  Our purpose was to extend knowledge on the immunogenetic spectrum of the disease.
  
  
  METHODS
  Sixteen anti-Ro(SS-A)-positive Japanese patients with recurrent annular erythema and Sjögren's syndrome were studied. The standard complement-dependent microcytotoxicity assay was used to type the HLA-A, -B, -C, -DR, and -DQ, as well as the HLA-DRw52 and -DRw53 antigens.
  
  
  RESULTS
  All 16 patients were positive for HLA-DRw52 antigens as compared with 52% of control subjects (p < 0.01 relative risk 14.8). No significant deviations were noted in the phenotype frequencies for HLA-A, -B, -C, and -DQ antigens.
  
  
  CONCLUSIONS
  HLA-DRw52 is closely related to annular erythema in anti-Ro(SS-A)-positive Japanese patients with Sjögren's syndrome.
authors.affiliation: Department of Dermatology, Nara Medical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyagawa
authors.forename: K
authors.initials: K
authors.lastname: Dohi
authors.forename: H
authors.initials: H
authors.lastname: Shima
authors.forename: T
authors.initials: T
authors.lastname: Shirai
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D002648:Child; D004890:Erythema / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D012261:Ribonucleoproteins / Q000032:analysis*; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D012261:Ribonucleoproteins; C035356:SS-A antibodies