67Gallium-labeled liposomes with prolonged circulation: preparation and potential as nuclear imaging agents.
A method is described for 67Ga-labeling liposomes containing a polyethylene glycol coating which exhibit prolonged blood circulation, reduced liver and spleen uptake and accumulation in tumors. Applications as agents for diagnostic imaging and delivery of therapeutic agents are considered. Previous methods were adapted to compensate for the presence of low temperature phase transition phospholipids resulting in consistent loading with low levels of residual unentrapped label.
Woodle
M C
MC
Liposome Technology Inc., Menlo Park, CA 94025.
D000818:Animals; D005260:Female; D005710:Gallium Radioisotopes / Q000097:blood* / Q000493:pharmacokinetics; D008081:Liposomes / Q000378:metabolism*; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D008081:Liposomes