Sensitivity of different rat tumour strains to photodynamic treatment with chlorin e6.
Transplantable rat tumours (sarcoma M-1, sarcoma 45, alveolar liver cancer PC-1 and Pliss' lymphosarcoma) were used to study chlorin e6 accumulation in tumours and its photodynamic effect. Tumours were irradiated by krypton ion laser light (647 and 676 nm; 90 J cm-2) 15 min and 24 h after chlorin e6 injection at doses of 5 and 10 mg kg-1. The relationship between some morphological peculiarities of these tumour strains, photosensitizer accumulation in tumours and their response to the photodynamic treatment is discussed.
Kostenich
G A
GA
Department of Chemoradiotherapy, Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Zhuravkin
I N
IN
Furmanchuk
A V
AV
Zhavrid
E A
EA
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002735:Chlorophyllides; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy; D008027:Light; D008113:Liver Neoplasms / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy; D011166:Porphyrins / Q000097:blood / Q000627:therapeutic use* / Q000633:toxicity; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012513:Sarcoma, Experimental / Q000188:drug therapy; D012867:Skin / Q000187:drug effects / Q000473:pathology
D002735:Chlorophyllides; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C062985:phytochlorin