Elevated serum aminotransferase activity as an early manifestation of gluten-sensitive enteropathy.
Six children in whom long-standing hypertransaminasemia of unknown cause led to an initial diagnosis of chronic or protracted cryptogenic hepatitis were found to have asymptomatic celiac disease. Administration of a gluten-free diet caused a prompt improvement of both hepatic and intestinal biochemical/histologic abnormalities. Hepatic damage may be another "atypical" form of celiac disease in children.
Vajro
P
P
Department of Pediatrics, Pediatric Gastroenterology and Hepatology, II Faculty of Medicine, University of Naples, Italy.
Fontanella
A
A
Mayer
M
M
De Vincenzo
A
A
Terracciano
L M
LM
D'Armiento
M
M
Vecchione
R
R
D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005983:Glutens; D006521:Hepatitis, Chronic / Q000209:etiology / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D000637:Transaminases / Q000097:blood*
D005983:Glutens; D000637:Transaminases