title: Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.
abstract: Phosphorylase kinase (PHK) is a regulatory enzyme of the glycogenolytic pathway composed of a complex of four subunits. We recently mapped the muscle alpha-subunit gene (Phka) to the mouse X chromosome in a region syntenic with the proximal long arm of the human X chromosome and containing the human homologue of this gene, PHKA. We now report the mapping of the liver alpha-subunit gene to the telomeric end of the mouse X chromosome. This mapping position would suggest a location for the human liver alpha-subunit gene on the proximal short arm of the X chromosome, a region recently implicated in X-linked liver glycogenosis (XLG).
authors.affiliation: MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, United Kingdom.
authors.forename: Y
authors.initials: Y
authors.lastname: Geng
authors.forename: J M
authors.initials: JM
authors.lastname: Derry
authors.forename: J
authors.initials: J
authors.lastname: Hendrickx
authors.forename: P
authors.initials: P
authors.lastname: Coucke
authors.forename: P R
authors.initials: PR
authors.lastname: Willems
authors.forename: P J
authors.initials: PJ
authors.lastname: Barnard
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D008099:Liver / Q000201:enzymology*; D051379:Mice; D010764:Phosphorylase Kinase / Q000235:genetics*; D014960:X Chromosome
chemical_list: D010764:Phosphorylase Kinase