Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat.
The influence of serotonin on luteinizing hormone (LH) release caused by exposure to two acute stressors differing in their intensity (restraint in tubes and immobilization in woodboards) was studied in adult male rats. Inhibition of serotonin synthesis with p-chlorophenylalanine (PCPA) significantly abolished LH release caused by immobilization (IMO). Administration of the serotonin antagonists mianserine and methiothepin also eliminated LH release caused by IMO without altering basal LH levels. These data represent the first evidence that a classical neurotransmitter (serotonin) is involved in LH release caused by stress in the rat.
Armario
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Departamento de Biología Celular y Fisiología, Universidad Autónoma de Barcelona, Spain.
Martí
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Gavaldà
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López-Calderón
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D000208:Acute Disease; D000818:Animals; D010134:Fenclonine / Q000494:pharmacology; D007103:Immobilization; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D012727:Sex Characteristics; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology
D012702:Serotonin Antagonists; D012701:Serotonin; D007986:Luteinizing Hormone; D010134:Fenclonine