title: Acute right ventricular heart failure in a patient with renal cell carcinoma after interferon therapy.
abstract: In a patient with diffuse pulmonary metastases of a renal cell carcinoma the development of severe pulmonary hypertension is described after reaching a complete remission during treatment with r-IFN-alpha 2c and rIFN-gamma. Rechallenge with interferon after the discovery of recurrent disease did not lead to deterioration of the cardiopulmonary condition. Possible causative mechanisms are discussed.
authors.affiliation: Department of Medical Oncology, University Hospital Nijmegen, Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Kramers
authors.forename: P H
authors.initials: PH
authors.lastname: de Mulder
authors.forename: J D
authors.initials: JD
authors.lastname: Barth
authors.forename: D J
authors.initials: DJ
authors.lastname: Wagener
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D006352:Heart Ventricles; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage; D007371:Interferon-gamma / Q000008:administration & dosage; D007680:Kidney Neoplasms / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins; D007371:Interferon-gamma