Hyperparathyroidism induced by hypothyroidism.
The coexistence of hyperparathyroidism and thyroid tumors and/or chronic thyroiditis has raised the possibility of an etiologic relationship. The present study was designed to test the hypothesis that the chronic elevation of thyroid-stimulating hormone (TSH) is related to the development of hyperparathyroidism. Three groups of 24 rats each were treated for 12 weeks as follows: group 1 received propylthiouracil (PTU) in their deionized water; group 2 received PTU and thyroid hormone to suppress TSH and to serve as a control group for possible direct effects of PTU; and group 3 was not treated at all and served as another control group. At 12 weeks, 95% of group 1 rats (PTU only) showed hyperplasia of the parathyroids with a 30% mean increase in circulating parathormone.
Walker
R P
RP
Department of Otolaryngology, Loyola University, Maywood, Ill 60153.
Oslapas
R
R
Ernst
K
K
Hessel
P
P
Nayyar
R
R
Lawrence
A M
AM
Paloyan
E
E
D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000097:blood; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005260:Female; D006961:Hyperparathyroidism / Q000097:blood / Q000209:etiology*; D006965:Hyperplasia; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced / Q000150:complications*; D010280:Parathyroid Glands / Q000187:drug effects / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011441:Propylthiouracil / Q000008:administration & dosage / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D003692:Delayed-Action Preparations; D004343:Drug Implants; D010281:Parathyroid Hormone; D010758:Phosphorus; D011441:Propylthiouracil; D013972:Thyrotropin; D013974:Thyroxine; D002118:Calcium