title: Cirrhosis: multiobserver analysis of hepatic MR imaging findings in a heterogeneous population.
abstract: To investigate the magnetic resonance (MR) imaging findings of hepatic cirrhosis and the potential of MR imaging in differentiating cirrhosis from other hepatic abnormalities, three observers with different levels of expertise in MR imaging (specialist, experienced radiologist, and novice with special training) reviewed hepatic MR imaging examinations of 52 patients with biopsy-proved presence (n = 29) or absence (n = 23) of cirrhosis. All examinations included motion-compensated T1-weighted, T2-weighted, and flow-sensitive gradient-echo images. For all three observers, linear signal irregularity was more accurate than other findings. For the final diagnosis of cirrhosis, the specialist was most sensitive (76% at high threshold, 97% at low threshold), followed by the novice with special training (31% and 79%, respectively). Specificity was 100% for all observers at high threshold and 78%, 96%, and 87% for expert, experienced, and trained novice observers, respectively, at low threshold. Sensitivity did not vary regardless of severity of fibrosis, as determined independently by a hepatopathologist. MR imaging has the potential of offering a comprehensive noninvasive evaluation of patients with suspected cirrhosis, but considerable expertise is required at present.
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
authors.forename: D G
authors.initials: DG
authors.lastname: Mitchell
authors.forename: K E
authors.initials: KE
authors.lastname: Lovett
authors.forename: H W
authors.initials: HW
authors.lastname: Hann
authors.forename: S
authors.initials: S
authors.lastname: Ehrlich
authors.forename: J
authors.initials: J
authors.lastname: Palazzo
authors.forename: R
authors.initials: R
authors.lastname: Rubin
mesh_terms: D005189:False Positive Reactions; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013154:Spleen / Q000473:pathology; D014648:Varicose Veins / Q000175:diagnosis; D014682:Vena Cava, Inferior / Q000473:pathology