Brain lithium concentrations measured with lithium-7 magnetic resonance spectroscopy in patients with affective disorders: relationship to erythrocyte and serum concentrations.
Brain lithium concentrations were measured in eight patients with affective disorders using lithium-7 magnetic resonance spectroscopy (MRS). Brain lithium concentrations correlated better with serum concentrations (n = 23, r = 0.66, p < 0.001) than with erythrocyte concentrations (r = 0.44, p < 0.05). Because of previous data in animal experiments these results were unexpected, but the differences in cation transport mechanisms between neurons and erythrocytes may account for the results.
Kato
T
T
Department of Psychiatry, University of Medical Science, Shiga, Japan.
Shioiri
T
T
Inubushi
T
T
Takahashi
S
S
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000493:pharmacokinetics* / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011618:Psychotic Disorders / Q000097:blood* / Q000188:drug therapy / Q000523:psychology
D016651:Lithium Carbonate