title: Temporal variation in bacterial disease frequency: molecular population genetic analysis of scarlet fever epidemics in Ottawa and in eastern Germany.
abstract: In an effort to understand the molecular genetic basis of temporal variation in frequency and severity of bacterial disease, genetic relationships among strains of Streptococcus pyogenes that caused scarlet fever epidemics in Canada in the early 1940s and in eastern Germany in the 1960s to 1980s were studied. Application of multilocus enzyme electrophoresis and comparative sequencing of the gene (speA) encoding streptococcal pyrogenic exotoxin A (scarlet fever toxin) revealed that new waves of scarlet fever are associated with an increase in frequency of S. pyogenes clones carrying variant speA alleles. This finding suggests that the occurrence of new scarlet fever epidemics can be predicted by comprehensive monitoring of the frequency of S. pyogenes clones with variant toxin alleles.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: J M
authors.initials: JM
authors.lastname: Musser
authors.forename: K
authors.initials: K
authors.lastname: Nelson
authors.forename: R K
authors.initials: RK
authors.lastname: Selander
authors.forename: D
authors.initials: D
authors.lastname: Gerlach
authors.forename: J C
authors.initials: JC
authors.lastname: Huang
authors.forename: V
authors.initials: V
authors.lastname: Kapur
authors.forename: S
authors.initials: S
authors.lastname: Kanjilal
mesh_terms: D000483:Alleles; D001426:Bacterial Proteins; D004196:Disease Outbreaks; D004586:Electrophoresis; D005098:Exotoxins / Q000235:genetics; D005859:Germany, East / Q000453:epidemiology; D006801:Humans; D008565:Membrane Proteins; D009864:Ontario / Q000453:epidemiology; D011749:Pyrogens / Q000235:genetics; D012541:Scarlet Fever / Q000453:epidemiology*; D013297:Streptococcus pyogenes / Q000235:genetics*; D013997:Time Factors
chemical_list: D001426:Bacterial Proteins; D005098:Exotoxins; D008565:Membrane Proteins; D011749:Pyrogens; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin