The association of age with gastric emptying.
Gastric emptying is important as a rate-limiting step in the absorption of orally administered drugs. Paracetamol absorption kinetics were used to compare gastric emptying in 19 fit elderly and 19 fit young volunteers. The results showed no significant difference in any of the derived parameters (t1/2abs, tlag and tmax) between the two groups. These results suggest that ageing does not impair this rate-limiting step in drug absorption.
Gainsborough
N
N
Department of Health Care of the Elderly, King's College School of Medicine and Dentistry, Denmark Hill, London.
Maskrey
V L
VL
Nelson
M L
ML
Keating
J
J
Sherwood
R A
RA
Jackson
S H
SH
Swift
C G
CG
D000082:Acetaminophen / Q000493:pharmacokinetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012016:Reference Values
D000082:Acetaminophen