title: Xanthoma disseminatum, a rare cause of diabetes insipidus.
abstract: A 33-yr-old male developed typical symptoms and findings of diabetes insipidus. A computed tomographic scan of the hypothalamus/pituitary was normal, and he was diagnosed as having idiopathic diabetes insipidus. At age 38 yr, he developed two 1- to 2-mm reddish papules on his skin. Biopsy revealed infiltrative histiocytes laden with lipid. Bone scans and bone x-rays showed widespread osteolytic and osteoblastic disease. The disease was diagnosed as a rare disseminated histiocytic disorder, xanthoma disseminatum. A classification of histiocytic disease is presented.
authors.affiliation: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
authors.forename: W D
authors.initials: WD
authors.lastname: Odell
authors.forename: R S
authors.initials: RS
authors.lastname: Doggett
mesh_terms: D000328:Adult; D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging; D003919:Diabetes Insipidus / Q000209:etiology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D011859:Radiography; D012867:Skin / Q000473:pathology