title: Magnetic resonance imaging with gadolinium contrast agent in small deep (lacunar) cerebral infarcts.
abstract: OBJECTIVE
  To assess gadolinium-diethylenetriamine-pentaacetic acid (Gd-DTPA) contrast-enhanced magnetic resonance (MR) imaging as an index of recent symptomatic small deep cerebral infarcts (SDCIs).
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  Primary-care center.
  
  
  METHODS
  Thirty-one consecutive patients presenting with the clinical diagnosis of SDCI in the territory of the perforators of the internal carotid artery or the vertebrobasilar system and confirmed by MR imaging.
  
  
  METHODS
  Rapid intravenous infusion of Gd-DTPA 5 to 10 minutes prior to acquisition of T1-weighted images.
  
  
  METHODS
  Precise clinicotopographic correlation on MR scans.
  
  
  RESULTS
  Non-contrast-enhanced MR imaging allowed precise clinicotopographic correlation in five (38%) of 13 patients with SDCI symptoms in the internal carotid artery territory. After Gd-DTPA administration, precise clinicotopographic correlation improved in 11 (85%) of 13 patients. In five patients, precise correlation was possible only after Gd-DTPA enhancement. Nonenhanced MR imaging allowed precise clinicotopographic correlation in 15 (83%) of 18 patients with SDCI symptoms in the vertebrobasilar territory. After Gd-DTPA administration, we could establish precise clinicotopographic correlation in all patients with SDCIs in the vertebrobasilar territory. In three patients, precise correlation was possible only after Gd-DTPA contrast enhancement. In seven (23%) of 31 patients, Gd-DTPA failed to enhance symptomatic lesion: in five patients MR scans were performed early (less than 7 days) and in two patients later in the course (greater than 7 days).
  
  
  CONCLUSIONS
  Although Gd-DTPA administration is unlikely to improve the sensitivity of MR images in visualizing SDCIs, it significantly improves the rate of precise clinicoanatomic correlation. All enhancing lesions showed precise clinicotopographic correlation. Enhancement may be absent in the acute phase (less than 7 days).
authors.affiliation: Department of Neurosurgery, University Hospital Lausanne, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Regli
authors.forename: F
authors.initials: F
authors.lastname: Regli
authors.forename: P
authors.initials: P
authors.lastname: Maeder
authors.forename: J
authors.initials: J
authors.lastname: Bogousslavsky
mesh_terms: D000368:Aged; D001488:Basilar Artery; D002339:Carotid Arteries; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000503:physiopathology; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid; D014711:Vertebral Artery
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA