title: A linkage study in seven breast cancer families.
abstract: Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.
authors.affiliation: Cancer Research Campaign Pediatric and Familial Cancer Research Group, Christie Hospital, Manchester, England.
authors.forename: M D
authors.initials: MD
authors.lastname: Teare
authors.forename: M F
authors.initials: MF
authors.lastname: Santibáñez-Koref
authors.forename: S A
authors.initials: SA
authors.lastname: Wallace
authors.forename: G R
authors.initials: GR
authors.lastname: White
authors.forename: D G
authors.initials: DG
authors.lastname: Evans
authors.forename: L D
authors.initials: LD
authors.lastname: Burnell
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: A
authors.initials: A
authors.lastname: Howell
authors.forename: J M
authors.initials: JM
authors.lastname: Birch
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010375:Pedigree; D011519:Proto-Oncogenes
chemical_list: D005819:Genetic Markers