Severe skin necrosis following warfarin therapy in a patient with protein C deficiency.
A female patient with a history of both arterial and venous thrombosis developed extensive skin necrosis following warfarin treatment. When protein C deficiency was diagnosed, successful anticoagulation with warfarin was achieved by prolonging the course of intravenous heparin and introducing warfarin therapy with a low initial dose which was gradually increased. Aspects of the pathogenic mechanism are discussed.
Locht
H
H
Department of Medicine, University Hospital Linköping, Sweden.
Lindström
F D
FD
D000328:Adult; D005260:Female; D006801:Humans; D009336:Necrosis / Q000139:chemically induced; D020151:Protein C Deficiency; D012867:Skin / Q000473:pathology*; D013927:Thrombosis / Q000188:drug therapy; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
D014859:Warfarin