Rebound thymic hyperplasia following high dose chemotherapy and allogeneic BMT.
We describe a child with acute lymphoblastic leukemia who showed mediastinal widening 8 months after allogeneic BMT. Total thymectomy was carried out by the transcervical approach. Histologic examination showed only thymic hyperplasia. The immunohistologic investigation revealed a normal distribution of thymic cell elements, without evidence of clonal proliferation of lymphocytic subpopulations. This case supports the hypothesis that thymic hyperplasia following chemotherapy may be merely a rebound phenomenon. The patient had an uneventful postoperative recovery and remains in remission more than 1 year after BMT.
Miniero
R
R
Department of Pediatrics, University of Turin, Italy.
Busca
A
A
Leonardo
E
E
Mossetti
C
C
Machado
D
D
Vassallo
E
E
Madon
E
E
D000945:Antigens, Differentiation, T-Lymphocyte; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000601:surgery; D013934:Thymectomy; D013952:Thymus Hyperplasia / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery
D000945:Antigens, Differentiation, T-Lymphocyte; D000970:Antineoplastic Agents