title: The value of flow cytometric analysis in patients with gastric cancer.
abstract: Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31% vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival.
authors.affiliation: Department of Surgery, Long Island Jewish Medical Center, Albert Einstein College of Medicine, NY.
authors.forename: H
authors.initials: H
authors.lastname: Johnson
authors.forename: C
authors.initials: C
authors.lastname: Belluco
authors.forename: S
authors.initials: S
authors.lastname: Masood
authors.forename: A M
authors.initials: AM
authors.lastname: Abou-Azama
authors.forename: L
authors.initials: L
authors.lastname: Kahn
authors.forename: L
authors.initials: L
authors.lastname: Wise
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002299:Cardia / Q000473:pathology; D004247:DNA / Q000235:genetics*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015993:Life Tables; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D011706:Pyloric Antrum / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate
chemical_list: D004247:DNA