title: Residues of endosulfan in the tissues of lactating goats.
abstract: The sites of tissue accumulation in lactating goats of the organochlorine insecticide endosulfan were studied. Twelve lactating goats were dosed orally with endosulfan (1 mg/kg body weight per day) for 28 days. Groups of 3 animals were killed on days 1, 8, 15, and 21 after endosulfan treatment ended and their tissues examined for the presence of endosulfan. Total residues of alpha and beta endosulfan and endosulfan sulphate (mg/kg) were detected in kidney (0.29), gastro-intestinal tract (0.20), liver (0.12), brain (0.06), muscle and spleen (0.04), lung and heart (0.01) and milk (0.02) on the first sampling day but within 15 days, concentrations had fallen to < 0.01 mg/kg in all tissues except kidney (0.20). Endosulfan could not be detected in animals 21 days after dosing had ceased. The residue in milk could only be detected on day 1 of sampling. This study indicates that kidney rather than fatty tissue should be used to monitor the presence of endosulfan in animals intended for human consumption.
authors.affiliation: Graduate School of Tropical Veterinary Science, James Cook University of North Queensland, Townsville.
authors.lastname: Indraningsih
authors.forename: C S
authors.initials: CS
authors.lastname: McSweeney
authors.forename: P W
authors.initials: PW
authors.lastname: Ladds
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D002849:Chromatography, Gas; D004726:Endosulfan / Q000493:pharmacokinetics*; D005260:Female; D006041:Goats / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D007774:Lactation / Q000378:metabolism*; D008892:Milk / Q000378:metabolism; D010573:Pesticide Residues / Q000493:pharmacokinetics*; D011247:Pregnancy; D014018:Tissue Distribution
chemical_list: D010573:Pesticide Residues; D004726:Endosulfan