Pharmacological effects of cefclidin on the central nervous system.
The effects of cefclidin (CFCL), a novel antibacterial agent, on the central nervous system (CNS) were examined in a variety of animal models. The effects of cefazolin (CEZ) were also examined for comparative purposes. In the animal models used CFCL whilst having some effects at the doses examined, failed to show an overall consistent effect on the CNS. In contrast CEZ produced changes in the parameters measured which were generally consistent with a proconvulsant action.
Kaneko
T
T
Tsukuba Research, Laboratories, Eisai Co., Ltd.
Katsu
K
K
Fujimoto
M
M
Yamauchi
H
H
Algate
D R
DR
Beard
D J
DJ
Jobling
C M
CM
Munt
P L
PL
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D002511:Cephalosporins / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D002511:Cephalosporins; C056494:cefclidin