A prospective clinical evaluation of an equation to predict daily lithium dose.
BACKGROUND
Conclusions about the usefulness of lithium dose-prediction equations are often based on retrospective evaluations, and the paucity of prospective tests is striking.


METHODS
We prospectively evaluated the safety and accuracy of a lithium-dose prediction equation in a group of 29 psychiatric patients. Predicted doses were computed and rounded to the nearest multiple of 300 mg, and the respective doses of lithium carbonate were given either two or three times a day. On Day 4 or 5 following treatment initiation, morning blood samples were collected 8 to 12 hours after administration of the last dose. Patients were monitored carefully for signs of lithium toxicity.


RESULTS
All 29 subjects achieved lithium concentrations between 0.5 and 1.3 mmol/L within 5 days of beginning treatment, and no participant showed any signs of lithium toxicity.


CONCLUSIONS
The equation may be a safe, reasonable alternative to empiric dosing.
Cummings
M A
MA
Department of Psychiatry, Loma Linda University School of Medicine, Calif.
Haviland
M G
MG
Wareham
J G
JG
Fontana
L A
LA
D000328:Adult; D000465:Algorithms; D000553:Ambulatory Care; D003866:Depressive Disorder / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D006760:Hospitalization; D006801:Humans; D016651:Lithium Carbonate / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D008962:Models, Theoretical; D011336:Probability; D011446:Prospective Studies
D016651:Lithium Carbonate