title: The influence of severe bone loss on mitral annular calcification in postmenopausal osteoporosis of elderly Japanese women.
abstract: We assessed the influence of aging bone calcium metabolism on mitral annular calcification (MAC) and aortic valve calcification (AVC) in 239 septua- and octogenarians (62 men, 177 women; 80.2 +/- 4.4 years). Osteoporosis was diagnosed by vertebral bone fracture. Both MAC and AVC were derived by 2-dimensional echocardiography. Bone mineral content (BMC) of the lumbar vertebral body was obtained by single-energy quantitative computed tomography using a calibration phantom. Serum calcium, phosphorus, parathyroid hormone, calcitonin, and osteocalcin were examined. Patients were classified into 3 age-matched groups in each sex: Group-C included patients with MAC (-) and AVC (-) (n = 96); Group-A was those with AVC (+) and MAC (-) (n = 80); Group-M consisted of those with MAC (+) and AVC (-) or AVC (+) (n = 63). Osteoporosis-frequency and BMC in women were significantly higher (p < 0.01) and lower (p < 0.001) respectively than those in men. Among men, osteoporosis-frequency and BMC showed no difference between the 3 groups. Among women, osteoporosis-frequency (52%) and BMC (32 +/- 23 mg/cm3) in Group-M were higher (NS) and significantly less (p < 0.01) than those (37%, 49 +/- 36) in Group-C, respectively. In both sexes, serum examinations revealed no differences between the 3 groups. These results suggest that: 1) MAC in elderly women can be attributed to ectopic calcium deposits, related to the severe bone loss caused by postmenopausal osteoporosis; 2) there is no significant relationship between the incidence of MAC or AVC and the humoral factors of calcium metabolism; and 3) AVC may be mainly caused by pressure or stress loading.
authors.affiliation: Second Department of Internal Medicine, Yamaguchi University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sugihara
authors.forename: M
authors.initials: M
authors.lastname: Matsuzaki
mesh_terms: D000368:Aged; D000375:Aging; D001021:Aortic Valve / Q000473:pathology*; D015519:Bone Density; D002114:Calcinosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood; D004452:Echocardiography; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008943:Mitral Valve / Q000473:pathology*; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000150:complications*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D015675:Osteocalcin; D010758:Phosphorus; D002116:Calcitonin; D002118:Calcium