title: T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo.
abstract: The role of T cells expressing specific V beta elements was examined in the regulation of allergen-specific immunoglobulin (Ig)E production and airways responsiveness (AR). In BALB/c mice, inhalation of the allergen ovalbumin (OVA) induced an IgE anti-OVA response, immediate cutaneous reactivity, and increased AR. These results were associated with an expansion of V beta 8.1/8.2 T cells in local draining lymph nodes of the airways and the lung. Transfer of V beta 8.1/8.2 T cells from sensitized mice stimulated an IgE anti-OVA response, immediate cutaneous hypersensitivity, and increased AR in naive syngeneic recipients. In contrast, OVA-reactive V beta 2 T cells inhibited these effects. These data demonstrate for the first time that T cells with different V beta specificities play a critical role in the in vivo regulation of allergen-specific IgE production and AR.
authors.affiliation: Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
authors.forename: H
authors.initials: H
authors.lastname: Renz
authors.forename: K
authors.initials: K
authors.lastname: Bradley
authors.forename: J
authors.initials: J
authors.lastname: Saloga
authors.forename: J
authors.initials: J
authors.lastname: Loader
authors.forename: G L
authors.initials: GL
authors.lastname: Larsen
authors.forename: E W
authors.initials: EW
authors.lastname: Gelfand
mesh_terms: D000485:Allergens; D000818:Animals; D016535:Bronchial Hyperreactivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation
chemical_list: D000485:Allergens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D007073:Immunoglobulin E