title: Intrahepatic portosystemic vascular stents: a bridge to hepatic transplantation.
abstract: Refractory esophageal variceal hemorrhage (EVH) remains a formidable problem in patients awaiting liver transplantations. Transjugular intrahepatic portosystemic shunts (TIPS) have provided an alternative approach for managing EVH that may obviate the need for portosystemic shunt surgery. Experience with TIPS placement and subsequent successful hepatic transplantation in patients without previous portosystemic shunt surgery has not been previously reported. Two patients are reported who underwent TIPS placement and subsequent successful hepatic transplantation without previous portosystemic shunt surgery. This experience indicates that (1) TIPS can provide effective control of EVH for at least several weeks, (2) TIPS placement decreases portal hypertension, thus facilitating technical performance of the transplant procedure and minimizing blood loss, (3) TIPS may undergo vascular incorporation, thus requiring that they be accurately positioned so that the lengths of suprahepatic inferior vena cava and portal vein are not compromised at the time of transplantation, (4) TIPS thrombosis can be effectively treated and prolonged patency may be observed, and (5) deterioration in hepatic function and exacerbation of hepatic encephalopathy were not observed after TIPS placement. In summary, TIPS provide an attractive, effective means for managing refractory EVH in patients awaiting liver transplantation.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, Mo.
authors.forename: E S
authors.initials: ES
authors.lastname: Woodle
authors.forename: M
authors.initials: M
authors.lastname: Darcy
authors.forename: H M
authors.initials: HM
authors.lastname: White
authors.forename: G A
authors.initials: GA
authors.lastname: Perdrizet
authors.forename: T M
authors.initials: TM
authors.lastname: Vesely
authors.forename: D
authors.initials: D
authors.lastname: Picus
authors.forename: M
authors.initials: M
authors.lastname: Hicks
authors.forename: S K
authors.initials: SK
authors.lastname: So
authors.forename: M D
authors.initials: MD
authors.lastname: Jendrisak
authors.forename: C S
authors.initials: CS
authors.lastname: McCullough
mesh_terms: D004932:Esophageal and Gastric Varices / Q000150:complications; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D016031:Liver Transplantation; D008875:Middle Aged; D011170:Portasystemic Shunt, Surgical / Q000295:instrumentation*; D015607:Stents; D014654:Vascular Patency