title: Prospective randomized comparison of in situ and reversed infrapopliteal vein grafts.
abstract: A three-centre prospective randomized trial was undertaken to compare the efficacy of in situ and reversed saphenous vein grafts for long bypasses to tibial and peroneal arteries. Of 162 patients entered into the study, 82 received an in situ graft and 80 a reversed vein graft. All operations were for limb salvage and the two groups of patients were well matched for age, sex, incidence of diabetes, smoking habits and coronary artery disease. At a maximum follow-up of 3 years there were 48 primary graft failures: 19 in the in situ group and 29 in the reversed vein group. Of these, three in situ grafts and seven reversed grafts were salvaged by secondary intervention. Secondary cumulative patency rates calculated at 3 years after operation were 68 and 66 per cent respectively for in situ and reversed grafts (P not significant). Cumulative limb salvage rates were 78 per cent for in situ grafts and 87 per cent for reversed grafts (P not significant). Separate analysis of a subgroup with small veins (< or = 3.5 mm minimum diameter) showed cumulative patency rates at 2 years of 74 per cent for in situ grafts and 60 per cent for reversed grafts (P not significant). These results indicate that for veins > 3.5 mm in diameter the in situ and reversed techniques for operation are equally effective. Some doubt remains about the best way of using smaller veins; a large number of such veins need to be studied to resolve this question.
authors.affiliation: Department of Vascular Surgery, Broadgreen Hospital, Liverpool, UK.
authors.forename: P L
authors.initials: PL
authors.lastname: Harris
authors.forename: F J
authors.initials: FJ
authors.lastname: Veith
authors.forename: G D
authors.initials: GD
authors.lastname: Shanik
authors.forename: D
authors.initials: D
authors.lastname: Nott
authors.forename: K R
authors.initials: KR
authors.lastname: Wengerter
authors.forename: D J
authors.initials: DJ
authors.lastname: Moore
mesh_terms: D000368:Aged; D001807:Blood Vessel Prosthesis / Q000379:methods; D005260:Female; D005268:Femoral Vein / Q000601:surgery*; D006084:Graft Rejection; D006801:Humans; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008297:Male; D011152:Popliteal Vein / Q000601:surgery*; D011446:Prospective Studies; D012501:Saphenous Vein / Q000637:transplantation*; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency