The metabolic response of articular cartilage to abnormal mechanical loading induced by medial or lateral meniscectomy.
The effects of medial versus lateral meniscectomy on articular cartilage (AC) of adult sheep was investigated. In vitro incorporation of 35S into proteoglycans (PGs) and their release into media was used to assess cartilage metabolism. Lateral meniscectomy produced higher loss of PGs from AC and lower 35S-PG biosynthesis than for AC from medial meniscectomized joints. These findings were consistent with the proposed role of the lateral meniscus in joint mechanics.
Ghosh
P
P
Raymond Purves Research Laboratories, University of Sydney, Royal North Shore Hospital of Sydney, St. Leonards, New South Wales, Australia.
Numata
Y
Y
Smith
S
S
Read
R
R
Armstrong
S
S
Johnson
K
K
D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism* / Q000502:physiology; D005270:Femur Head / Q000502:physiology; D008592:Menisci, Tibial / Q000502:physiology* / Q000601:surgery; D010329:Patella / Q000378:metabolism / Q000502:physiology; D011509:Proteoglycans / Q000096:biosynthesis; D012756:Sheep; D013462:Sulfur Radioisotopes
D011509:Proteoglycans; D013462:Sulfur Radioisotopes