title: Onychomycosis: successful treatment with once-weekly fluconazole.
abstract: We report a case of fingernail onychomycosis in an immunosuppressed renal transplant patient who was successfully treated with once-weekly fluconazole therapy. Relapse did not develop over the 2-month follow-up period. There were no adverse effects from therapy and the cyclosporin dose did not require adjustment. This case suggests that fluconazole may play a role in the treatment of onychomycosis with once-weekly dosing schedules. Future large-scale clinical trials are indicated to fully evaluate its safety and efficacy in onychomycosis.
authors.affiliation: Division of Dermatology, St. Louis University Medical Center, MO 63104.
authors.forename: G T
authors.initials: GT
authors.lastname: Nahass
authors.forename: M
authors.initials: M
authors.lastname: Sisto
mesh_terms: D004334:Drug Administration Schedule; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006229:Hand Dermatoses / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy* / Q000276:immunology; D012074:Remission Induction
chemical_list: D015725:Fluconazole