The patterns and treatment of recurrence following radiotherapy for carcinoma of the oral cavity.
In many centres carcinoma of the oral cavity, if relatively early, is treated by irradiation. The present study includes 186 patients treated in this manner. The primary recurrence rate for previously untreated patients was 34% and was not significantly affected by host or tumour factors. The 5-year survival for the 144 previously untreated patients was 65%, and salvage surgery offered a 35% chance of cure. Survival was reduced in patients aged 60 years and over (P < 0.02). The recurrence rate in cervical lymph nodes following radiotherapy was 38% and was more likely to occur for primary sites in the tongue and floor of mouth (P < 0.01). The five-year survival rate after nodal recurrences was 31% and was predicted only by the presence of extracapsular rupture (P < 0.01). One-third of patients had died of causes other than the primary tumour at 5 years and one-third had died of the original tumour. The rest of the patients are alive and well, only 7% having had a major resection. We feel that the present policy has optimum cure rate whilst saving most patients from major surgery.
Jones
A S
AS
Department of Otorhinolaryngology, University of Liverpool, Royal Liverpool Hospital, UK.
Khan
H
H
D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009062:Mouth Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D015996:Survival Rate