[The effect of organophosphorus pesticide (fenthion) on GABA-cells in the central nuclei].
Organophosphorus pesticide (OP) produces abnormal eye movements. This is possibly due to an inhibition of central cholinergic neurons as well as GABAnergic neurons. Using anti-GABA-antibody, the authors studied the effect of OP on GABA-positive cells in the central nervous system. Fenthion (dimethyl 4-methylthion-m-tolyl-phosphorothionate, 20 mg/kg body weight), was given subcutaneously to the dorsal portion of Wistar rats for 30 days. After staining, the number of GABA-positive cells were counted at the superior colliculus (SC), the cerebellum, and the substantia nigra reticularis (SNR) on day 6, 10, 14, 18, 22, 26 and 30 respectively. The number of GABA-positive cells reduced in the cerebellum, SNR and SC decreasing remarkably after the initiation of fenthion administration. The number of GABA-positive cells also decreased in lateral geniculate nucleus and pretectal nuclei. Those results suggest that the reduction of GABA-positive cells produces abnormal eye movements in human OP intoxication.
Kojima
Y
Y
Department of Ophthalmology, School of Medicine, Kitasato University, Sagamihara, Japan.
Sekiya
H
H
Ishikawa
S
S
D000818:Animals; D001933:Brain Stem / Q000737:chemistry / Q000187:drug effects*; D002531:Cerebellum / Q000737:chemistry / Q000187:drug effects; D005133:Eye Movements / Q000187:drug effects*; D005284:Fenthion / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000737:chemistry / Q000187:drug effects; D013477:Superior Colliculi / Q000737:chemistry / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000032:analysis* / Q000187:drug effects
D005680:gamma-Aminobutyric Acid; D005284:Fenthion