Anuran calling circuits: inhibition of pretrigeminal nucleus by prostaglandin.
Neural correlates of mating calling and pulmonary respiration were recorded from isolated brain stems of male Northern leopard frogs (Rana p. pipiens) before and after exposure of the brain stems to prostaglandin F2 alpha (PG) or saline. Diffusion of PG (but not saline) from a pipette directly over the pretrigeminal nuclei abolished "calling" temporarily. Similar application of PG nearby had no effect. Exposure of only the anterior 1/2 of the brain stem, containing the pretrigeminal nuclei but not the pulmonary respiration generator, to PG (but not saline) abolished generation of slow waves by the pretrigeminal nucleus portion of the mating calling pattern generator. Exposure of only the posterior 1/2 of the brain stem, containing the pulmonary respiration generator but not the pretrigeminal nuclei, to PG had no effect on the correlates of pulmonary respiration. These results are consistent with the hypothesis that the inhibition of calling by PG is through an effect largely, perhaps exclusively, on the pretrigeminal nuclei.
Schmidt
R S
RS
Department of Pharmacology, Loyola University of Chicago Stitch School of Medicine, Maywood, Illinois 60153.
D000818:Animals; D001931:Brain Mapping; D001933:Brain Stem / Q000502:physiology; D003307:Copulation / Q000502:physiology; D015237:Dinoprost / Q000502:physiology*; D005260:Female; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D010058:Oviposition / Q000502:physiology; D011894:Rana pipiens / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013018:Sound Spectrography; D014278:Trigeminal Nuclei / Q000502:physiology*; D014828:Vocalization, Animal / Q000502:physiology*
D015237:Dinoprost