title: The international standard for interleukin-6. Evaluation in an international collaborative study.
abstract: Three ampouled preparations of interleukin-6 (IL-6) were evaluated by 12 laboratories in seven countries for their suitability to serve as the international standard of IL-6. The preparations were assayed using in vitro bioassays and immunoassays. On the basis of the results reported here, with the agreement of the participants in the study and with the authorization of the Expert Committee on Biological Standardization (ECBS) of the World Health Organization (WHO) one of the preparations (coded 89/548) was established as the international standard of IL-6.
authors.affiliation: Informatics Laboratory and Division of Endocrinology, National Institute for Biological Standards and Control, Potters Bar, Herts, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: Gaines Das
authors.forename: S
authors.initials: S
authors.lastname: Poole
mesh_terms: D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006801:Humans; D007118:Immunoassay; D015850:Interleukin-6 / Q000592:standards*; D014944:World Health Organization
chemical_list: D015850:Interleukin-6