[Studies on pharmacokinetics of platinum after internal iliac artery infusion of cisplatin in rabbits].
The purpose of this study was to evaluate the usefulness of internal iliac artery infusion chemotherapy with cisplatin (CDDP) for uterine cancer. The rabbit model for internal iliac artery infusion was designed and then induced. The rabbits (average BW 3.5kg) were treated with CDDP (1.7mg/kg) via either the internal iliac artery (IA) or peripheral vein (IV) as the control. The rabbits were infused with CDDP via the IA for 2 minutes, 20 minutes or 2 hours, or via IV for 2 minutes or 20 minutes. Platinum (Pt) concentrations were measured in the serum and tissues of the uterus and kidney after CDDP infusion. Concentrations of filtrated Pt in serum were significantly lower and concentrations of Pt in uterine tissue were significantly higher after IA infusion. The highest concentration of Pt in uterine tissue was obtained after 20 minutes of IA infusion. However, the uterine Pt concentration after IA infusion for 2 hours did not differ from that after IV infusion. A significant amount of Pt was also retained in kidney tissue after IA infusion, which was not different from that after IV infusion. These findings with the rabbit model suggest that IA infusion of CDDP for 20 minutes is useful in treating uterine cancer.
Kanamori
Y
Y
Department of Obstetrics and Gynecology, Tottori University, Faculty of Medicine, Yonago.
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D007083:Iliac Artery; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D010984:Platinum / Q000493:pharmacokinetics*; D011817:Rabbits; D014018:Tissue Distribution; D014599:Uterus / Q000378:metabolism*
D010984:Platinum; D002945:Cisplatin