title: Prenatal alcohol exposure attenuates pentylenetetrazol-induced convulsions in rats.
abstract: Female rats prenatally exposed to alcohol were tested at 35 days of age for susceptibility to pentylenetetrazol (PTZ)-induced convulsions. There was a significant dose-response effect of PTZ. Contrary to expectations, alcohol-exposed females were slightly but still significantly less convulsion-prone than pair-fed controls. These results suggest prenatal alcohol exposure reduces the susceptibility to convulsions in rats.
authors.affiliation: Department of Obstetrics/Gynecology, Wayne State University, Detroit, MI.
authors.forename: E L
authors.initials: EL
authors.lastname: Abel
authors.forename: R F
authors.initials: RF
authors.lastname: Berman
authors.forename: M W
authors.initials: MW
authors.lastname: Church
mesh_terms: D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D010433:Pentylenetetrazole / Q000008:administration & dosage; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced*
chemical_list: D000431:Ethanol; D010433:Pentylenetetrazole