Upregulation of forebrain proenkephalin mRNA subsequent to NMDA receptor blockade.
Blockade of NMDA (N-methyl-D-aspartate) receptors for 5 h with MK 801 resulted in elevated levels of proenkephalin mRNA (up to 40% above vehicle-injected controls) in medial and anterior aspects of the caudate-putamen (mCPU and aCPU) and the nucleus accumbens (NAc). Increases were dose-dependent, with maximal effect at 0.1 mg/kg (body weight). These results suggest that NMDA receptor activity exerts tonic inhibition on proenkephalin mRNA expression in the striatum and accumbens of the rat brain.
Angulo
J A
JA
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
Watanabe
Y
Y
Cadet
J
J
Ledoux
M
M
McEwen
B S
BS
D000818:Animals; D001483:Base Sequence; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004745:Enkephalins / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D017072:Neostriatum / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D016548:Prosencephalon / Q000378:metabolism*; D011498:Protein Precursors / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D015854:Up-Regulation
D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; C029992:proenkephalin; D016291:Dizocilpine Maleate