Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis.
OBJECTIVE
To investigate the mode of inheritance of ulcerative colitis and Crohn's disease by complex segregation analysis.


METHODS
Cross sectional population based survey of familial occurrence of chronic inflammatory bowel disease.


METHODS
Population of the Copenhagen county in 1987.


METHODS
662 patients in whom inflammatory bowel disease had been diagnosed before 1979, of whom 637 (96%) provided adequate information. Of 504 patients with ulcerative colitis, 54 had 77 relatives with ulcerative colitis and of 133 patients with Crohn's disease, five had seven relatives with Crohn's disease.


METHODS
Patterns of segregation of either disease as assessed by complex segregation analysis performed with the computer program POINTER.


RESULTS
The analysis suggested that a major dominant gene with a penetrance of 0.20-0.26 is present in 9-13% of adult patients with ulcerative colitis. The analysis did not allow for other components in the familial aggregation. For Crohn's disease the best fitting model included a major recessive gene with complete penetrance, for which 7% of the patients are homozygous. However, this model was not significantly different from a multifactorial model.


CONCLUSIONS
The segregation pattern indicates that a major dominant gene has a role in ulcerative colitis, and suggests that a major recessive gene has a role in Crohn's disease.
Orholm
M
M
Gastroenterological Department C, Herlev Hospital, University of Copenhagen, Denmark.
Iselius
L
L
Sørensen
T I
TI
Munkholm
P
P
Langholz
E
E
Binder
V
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000235:genetics*; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D005787:Gene Frequency; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D008875:Middle Aged