title: New approaches with the Chem-1 creatinine determination.
abstract: Three modifications of the Chem-1 determination of serum creatinine were tested. Two different algorithms developed for compensating the interference of bilirubin were compared with the current one by analysing bilirubin-enriched albumin solutions and 82 icteric serum samples. A number of known other interfering substances were also tested. The modification involving parallel bichromatic measurement plus bilirubin correction appeared to give the best performance. However, despite the improvements, the determination is not yet completely satisfactory.
authors.affiliation: Academic Hospital Rotterdam-Dijkzigt, Department of Clinical Chemistry, The Netherlands.
authors.forename: B G
authors.initials: BG
authors.lastname: Blijenberg
authors.forename: L
authors.initials: L
authors.lastname: Zwang
authors.forename: M
authors.initials: M
authors.lastname: van Tilborg
mesh_terms: D000465:Algorithms; D001663:Bilirubin / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood*; D003524:Cyclosporins / Q000097:blood; D006801:Humans; D007565:Jaundice / Q000097:blood; D015203:Reproducibility of Results; D012709:Serum Albumin
chemical_list: D003524:Cyclosporins; D012709:Serum Albumin; D003404:Creatinine; D001663:Bilirubin