Regional blood flow volume in the eustachian tube.
Measurements of regional blood flow around the pharyngeal orifice of the Eustachian tube were carried out after topical administration of various inflammatory mediators in 14 mongrel dogs by the hydrogen clearance method. Histamine and platelet-activating factor (PAF) resulted in a significant alteration of blood flow volume. Histamine was found to induce a dose-response related increase, whereas blood flow volume tended to decrease in each concentration range in the series of PAF administration. There was no significant difference in blood flow between topical application of leukotriene C4 and leukotriene D4. It is likely that in upper respiratory tract inflammation, such as in otitis media and in nasal allergy, activated histamine and PAF affect the microcirculation of the tubal orifice. These results suggest that disturbance of the microcirculatory system in the Eustachian tube mucosa could be involved in the pathogenesis of chronic otitis media with effusion.
Minami
T
T
Department of Otolaryngology, Kansai Medical University, Osaka, Japan.
Kubo
N
N
Tomoda
K
K
Yamashita
T
T
Kumazawa
T
T
D000818:Animals; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005064:Eustachian Tube / Q000098:blood supply*; D006632:Histamine / Q000494:pharmacology; D010034:Otitis Media with Effusion / Q000503:physiopathology*; D010972:Platelet Activating Factor / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013189:SRS-A / Q000494:pharmacology
D010972:Platelet Activating Factor; D013189:SRS-A; D006632:Histamine