Diethylstilbestrol liver carcinogenicity and modification of DNA in rats.
Administration of diethylstilbestrol to female Sprague-Dawley rats at 10 mg/kg body weight daily by gavage for 1 year induced liver adenomas and carcinomas and pituitary adenomas. Using the 32P-postlabeling assay for DNA alterations, at 24 h after administration of a single dose of 100 mg/kg, modified bases were found.
Williams
G M
GM
American Health Foundation, Valhalla, NY 10595.
Iatropoulos
M
M
Cheung
R
R
Radi
L
L
Wang
C X
CX
D000236:Adenoma / Q000139:chemically induced / Q000235:genetics*; D000818:Animals; D001345:Autoradiography; D001835:Body Weight / Q000187:drug effects; D002277:Carcinoma / Q000139:chemically induced / Q000235:genetics*; D004247:DNA / Q000187:drug effects*; D004054:Diethylstilbestrol / Q000633:toxicity*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D010911:Pituitary Neoplasms / Q000139:chemically induced; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D004054:Diethylstilbestrol; D004247:DNA