title: Pathogenesis of cobalamin neuropathy: deficiency of nervous system S-adenosylmethionine?
abstract: Low levels of cerebrospinal S-adenosylmethionine in association with abnormal myelination in inherited disorders affecting cobalamin and folate metabolism provide new data on a possible mechanism of cobalamin neuropathy.
authors.affiliation: University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: J
authors.initials: J
authors.lastname: Metz
mesh_terms: D002675:Child, Preschool; D005492:Folic Acid / Q000378:metabolism; D005494:Folic Acid Deficiency / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008661:Metabolism, Inborn Errors / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism*; D012436:S-Adenosylmethionine / Q000134:cerebrospinal fluid / Q000172:deficiency*; D014805:Vitamin B 12 / Q000378:metabolism*; D014806:Vitamin B 12 Deficiency / Q000378:metabolism
chemical_list: D012436:S-Adenosylmethionine; D005492:Folic Acid; D014805:Vitamin B 12