title: Early diagnosis of staphylococcal toxaemia in burned children.
abstract: The features of toxic shock syndrome in burned children have been described in a review of seven patients (J. D. Frame et al., Burns 1985; 11, 234). These include a 'prodromal' 24-48 h period with diarrhoea, vomiting, general malaise, pyrexia, tachycardia and tachypnoea. The white cell count and haemoglobin concentration fall prior to the 'shock' phase, which occurs 3-4 days postburn. Once 'shock' has occurred the mortality of the condition is approximately 50 per cent; in the absence of 'shock' it is much reduced. We have undertaken a retrospective review of six burned children who were admitted in a 2-year period to the Mount Vernon NHS Trust Burns Unit with a clinical diagnosis of toxic shock syndrome. The evidence from our patients suggests that reliable early diagnostic signs are a rapidly developing severe pyrexia of 39.5 degrees C or above, and a simultaneously increasing tachycardia and tachypnoea to high levels. There is a sudden profound fall in the white cell count and haemoglobin concentration over a period of hours between 1 and 3 days from injury. Specific treatment should be instituted before the onset of 'shock'. The name staphylococcal toxaemia might promote earlier diagnosis and treatment of this condition and so reduce its mortality.
authors.affiliation: R.A.F.T. Department of Research, Mount Vernon Hospital NHS Trust, Northwood, Middlesex, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: McAllister
authors.forename: N S
authors.initials: NS
authors.lastname: Mercer
authors.forename: B D
authors.initials: BD
authors.lastname: Morgan
authors.forename: R
authors.initials: R
authors.lastname: Sanders
mesh_terms: D001427:Bacterial Toxins; D002056:Burns / Q000150:complications*; D004768:Enterotoxins / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012772:Shock, Septic / Q000175:diagnosis* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology; D018089:Superantigens
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal