Impairment of saccadic eye movements by scopolamine treatment.
The effects of Scopolamine on the dynamics of saccadic eye movements, stimulated over a random time interval, have been investigated in humans. A 0.5-mg dose of the drug (intramuscular injection) had various influences on the basic saccadic parameters. For all subjects duration increased and peak velocity decreased, while for 50% of the subjects saccades became hypometric and latency increased. Standard deviation increased consistently too. Moreover, the Scopolamine treatment affected postsaccadic fixation; at the end of many saccades, the eye drifted considerably, but stability was recovered after a few seconds.
Oliva
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GA
Istituto di Cibernetica e Biofisica del C.N.R., Genova, Italia.
Bucci
M P
MP
Fioravanti
R
R
D000328:Adult; D003072:Cognition Disorders / Q000209:etiology; D005128:Eye Diseases / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D012438:Saccades / Q000187:drug effects*; D012601:Scopolamine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D012601:Scopolamine