title: Do magnesium infusions protect the inner ear during middle ear surgery? A randomized double blind study.
abstract: Joachims et al. recently demonstrated that magnesium was able to protect the inner ear during exposure to noise and fire arms. During middle ear surgery, the inner ear is subjected to noise from fraising and drilling. We saw fit, therefore, to conduct a random double blind study to establish whether magnesium infusions would protect the inner ear during middle ear surgery. We examined 80 patients (38 verum, 42 placebo). The verum patients received 10 mg/kg body weight magnesium 12 hours and 1 hour prior to operation. Plasma and red cell magnesium levels were measured pre-operatively and intra-operatively; they rose as expected. Post-operative auditory tests showed that magnesium had no tendency to prevent inner ear damage. Advocates of magnesium criticize the limited number of patients in our study as well as the administration of the magnesium substitute. In our opinion, however, it should be borne in mind when evaluating these findings that noise from drilling and fraising is only one factor among many which can induce inner ear injury during middle ear surgery.
authors.forename: M
authors.initials: M
authors.lastname: Pilgramm
authors.forename: H P
authors.initials: HP
authors.lastname: Köchy
authors.forename: M
authors.initials: M
authors.lastname: Schäfer
authors.forename: H P
authors.initials: HP
authors.lastname: Weibel
mesh_terms: D000328:Adult; D001309:Auditory Threshold / Q000187:drug effects; D004311:Double-Blind Method; D004432:Ear, Middle / Q000601:surgery*; D005260:Female; D006317:Hearing Loss, Noise-Induced / Q000517:prevention & control*; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage*; D008297:Male; D008416:Mastoid / Q000601:surgery; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013201:Stapes Surgery; D014433:Tympanoplasty
chemical_list: D008274:Magnesium