title: Rapid enzyme diagnosis of patients with acute chest pain reduces patient stay in the coronary care unit.
abstract: We have studied the effect of early exclusion of myocardial infarction using rapid biochemical diagnosis on the management of patients admitted to the coronary care unit of a district general hospital. Diagnosis was based on the rate of creatine kinase increase in serial samples obtained over the 8 h following admission. For an initial 3-month familiarization period serial creatinine kinase results were made available at the end of working day to supplement clinical management, supported by our traditional protocol of admission and daily enzyme determinations. Subsequently, for a 4-month period, the admission to 8 h serial values were provided by 1100 h each day and usually within 24 h of admission. There was a net reduction in length of stay on the coronary care unit to a median 2 days (n = 66) compared with 3 days (n = 41) for patients without further cardiac symptoms or electrocardiographic changes suggestive of ischaemia or infarction. This change was significant, P = 0.007, Mann-Whitney U test. Reversion to the original protocol of daily enzyme estimations resulted in an increase in the length of stay on the coronary care unit back to a median of 3 days for this patient group. Rapid diagnostic protocols, applied within routine clinical practice, have the potential for real reduction in coronary care unit stay.
authors.affiliation: Department of Clinical Biochemistry, West Middlesex University Hospital, Isleworth, UK.
authors.forename: P O
authors.initials: PO
authors.lastname: Collinson
authors.forename: E M
authors.initials: EM
authors.lastname: Ramhamadamy
authors.forename: P J
authors.initials: PJ
authors.lastname: Stubbs
authors.forename: S B
authors.initials: SB
authors.lastname: Rosalki
authors.forename: H M
authors.initials: HM
authors.lastname: Garrat
authors.forename: D
authors.initials: D
authors.lastname: Mosely
authors.forename: D H
authors.initials: DH
authors.lastname: Evans
authors.forename: R S
authors.initials: RS
authors.lastname: Fink
authors.forename: I M
authors.initials: IM
authors.lastname: Baird
authors.forename: T W
authors.initials: TW
authors.lastname: Greenwood
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood; D002637:Chest Pain / Q000175:diagnosis*; D003325:Coronary Care Units; D003402:Creatine Kinase / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D017048:Health Care Costs; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007902:Length of Stay; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis*; D017202:Myocardial Ischemia / Q000175:diagnosis
chemical_list: D006884:Hydroxybutyrate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase