A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.
Major histocompatibility complex (MHC)-linked deletions in the rat are associated with defects in growth and development and increased susceptibility to chemical carcinogens. The present study maps a locus critical for determining susceptibility to diethylnitrosamine (DEN) carcinogenesis by using two groups of MHC-recombinant rats congenic for the MHC and its linked region. Resistance to DEN segregates with a locus (rcc+) that maps between RT1.E and ft, and its homozygous loss markedly increases susceptibility to DEN. Non-MHC genes do not significantly influence the susceptibility of these strains to DEN. The existence of the rcc locus adds support to our hypothesis that some genes in the MHC-linked region play a major role in both normal and abnormal growth.
Melhem
M F
MF
Department of Pathology, University of Pittsburgh School of Medicine, PA 15261.
Kunz
H W
HW
Gill
T J
TJ
D000818:Animals; D001835:Body Weight; D004052:Diethylnitrosamine; D008040:Genetic Linkage; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D008285:Major Histocompatibility Complex; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012098:Reproduction
D004052:Diethylnitrosamine