Trends in neural tube defects 1980-1989.
OBJECTIVE
To determine trends in prevalence of neural tube defects in Australia over the past decade; to investigate the impact of terminations of pregnancy on the birth prevalence of neural tube defects; and to provide a baseline against which to evaluate the potential effects of preventive public health measures.


METHODS
Two population-based registries in Victoria and Western Australia and a statewide survey from Tasmania.


METHODS
A cohort study. Data on the numbers and the prevalence proportions of neural tube defects from three States--Western Australia, Victoria and Tasmania--were compared by Poisson regression.


RESULTS
The prevalence proportions for all neural tube defects for all three States remained level over the study period 1980-1989. Terminations of pregnancy for all neural tube defects increased significantly over the decade in all three States. By 1989, 39.9% of all neural tube defects were ascertained as terminations before 20 weeks' gestation, while 10 years previously only 2.9% were. The percentage of cases of anencephaly ascertained as terminations of pregnancy increased from 4.8% in 1980 to 58.6% in 1989. Corresponding figures for spina bifida were 1.4% (1980) and 26.9% (1989), and for encephalocele 0% (1980) and 12.5% (1989). This increase in terminations was associated with a decrease per year in the birth prevalence proportion for anencephaly of 7.0%, for spina bifida of 4%, and for encephalocele of 11.0%, and a reduction in the risk of a birth with a neural tube defect in 1989 of 47% compared with the risk in 1980.


CONCLUSIONS
Complete ascertainment of all terminations for neural tube defects as well as births with neural tube defects is necessary to provide reliable baseline data on the prevalence of neural tube defects. Such data are essential in evaluating primary preventive measures such as the effect of an increase in folic acid intake by women of child-bearing age.
Bower
C
C
Western Australian Research Institute for Child Health, Perth.
Raymond
M
M
Lumley
J
J
Bury
G
G
D000028:Abortion, Induced / Q000706:statistics & numerical data / Q000639:trends; D000757:Anencephaly / Q000453:epidemiology; D015331:Cohort Studies; D004677:Encephalocele / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000453:epidemiology*; D016012:Poisson Distribution; D011247:Pregnancy; D015995:Prevalence; D016135:Spinal Dysraphism / Q000453:epidemiology; D013648:Tasmania / Q000453:epidemiology; D014739:Victoria / Q000453:epidemiology; D014904:Western Australia / Q000453:epidemiology