Inhibition of heme oxygenase after oral vs intraperitoneal administration of chromium porphyrins.
The effects of chromium porphyrins on suckling rat heme oxygenase activity were compared following oral vs intraperitoneal dosing. Chromium protoporphyrin (CrPP), chromium mesoporphyrin (CrMP), or chromium deuteroporphyrin 2,4 bis glycol (CrBG) were administered at 40 mumol/kg to 2-week old suckling rats either orally or intraperitoneally. Six hours after intraperitoneal dosing, CrPP and CrMP had significantly reduced hepatic and splenic heme oxygenase activity by more than 55%. CrBG effectively reduced hepatic heme oxygenase activity by 42%. More importantly, only CrMP was an effective inhibitor of hepatic heme oxygenase activity 6 hr after oral administration. In the first reported comparison of chromium porphyrin efficacy in vivo, our data suggest that chromium porphyrins, and particularly CrMP, may be effective in chemopreventive strategies for the treatment of neonatal jaundice.
Vallier
H A
HA
Department of Pediatrics, Stanford University School of Medicine, CA 94305.
Rodgers
P A
PA
Stevenson
D K
DK
D000284:Administration, Oral; D000818:Animals; D000833:Animals, Suckling; D003905:Deuteroporphyrins / Q000494:pharmacology; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008652:Mesoporphyrins / Q000494:pharmacology; D008665:Metalloporphyrins / Q000494:pharmacology*; D011524:Protoporphyrins / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000201:enzymology
D003905:Deuteroporphyrins; D008652:Mesoporphyrins; D008665:Metalloporphyrins; D011524:Protoporphyrins; D006419:Heme Oxygenase (Decyclizing)