Cell and molecular biology of neural crest cell lineage diversification.
Neural crest cells are multipotent progenitor cells, but it is not understood how these cells generate their diverse differentiated progeny. This review considers the issues of whether neural crest cells self-renew, whether they generate partially committed intermediate progenitors, and how the local embryonic environment may act to control this diversification process. Novel molecular markers for neural crest cells are also discussed.
Anderson
D J
DJ
Howard Hughes Medical Institute, California Institute of Technology, Pasadena.
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D009432:Neural Crest / Q000166:cytology* / Q000196:embryology / Q000502:physiology; D013234:Stem Cells / Q000502:physiology