title: CA 494--a new tumor marker for the diagnosis of pancreatic cancer.
abstract: In 59 patients with ductal pancreatic cancer the monoclonal antibody (MAb) BW 494, which detects the CA 494 glycoprotein antigen, was analyzed in comparison with the reference tumor markers CA 19-9 and CEA. Eighty-one patients with non-pancreatic malignancies of the gastrointestinal (GI) tract, 95 with chronic pancreatitis, 124 with benign non-pancreatic GI diseases, 30 with diabetes mellitus (type I or type II) and 114 healthy blood donors served as controls. The sensitivity of pancreatic cancer was 90%, 44% and 90% for CA 19-9, CEA and CA 494, respectively. In chronic pancreatitis, as the most important control population for pancreatic cancer, the specificity was 85%, 72% and 94% for CA 19-9, CEA and CA 494, respectively.
authors.affiliation: Department of General Surgery, University of Ulm, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Friess
authors.forename: M
authors.initials: M
authors.lastname: Büchler
authors.forename: B
authors.initials: B
authors.lastname: Auerbach
authors.forename: A
authors.initials: A
authors.lastname: Weber
authors.forename: P
authors.initials: P
authors.lastname: Malfertheiner
authors.forename: K
authors.initials: K
authors.lastname: Hammer
authors.forename: N
authors.initials: N
authors.lastname: Madry
authors.forename: S
authors.initials: S
authors.lastname: Greiner
authors.forename: K
authors.initials: K
authors.lastname: Bosslet
authors.forename: H G
authors.initials: HG
authors.lastname: Beger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000097:blood; D010190:Pancreatic Neoplasms / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen