Suspected nafcillin-induced interstitial nephritis.
OBJECTIVE
To present a case of nafcillin-induced interstitial nephritis.


METHODS
Case report and literature review.


METHODS
Hospital.


RESULTS
Three days following initiation of nafcillin therapy for staphylococcal pneumonia, an 80-year-old woman developed allergic manifestations and progressive renal impairment suggestive of acute allergic interstitial nephritis. These manifestations were completely reversed within 96 hours of cessation of nafcillin therapy.


CONCLUSIONS
In the clinical setting of acute renal failure in a patient on nafcillin therapy, acute interstitial nephritis should be considered. Prompt cessation of nafcillin therapy has generally been associated with reversal of symptoms and an improvement in renal function.
Guharoy
S R
SR
John F. Kennedy Memorial Hospital, Indio, CA 92201.
Kar
S
S
McGalliard
J
J
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D007958:Leukocyte Count; D009254:Nafcillin / Q000009:adverse effects*; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D011023:Pneumonia, Staphylococcal / Q000150:complications / Q000188:drug therapy
D009254:Nafcillin