Antitumor effect of chemically synthesized (+)-goniopypyrone.
Chemically synthesized (+)-goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED50 values were found to be 35 and 30 micrograms/ml for the two cell lines used. An LD50 of 193 micrograms/ml was observed in the brine shrimp bioassay.
Shing
T K
TK
Department of Chemistry, Chinese University of Hong Kong, Shatin, N.T.
Look
M
M
Choy
Y M
YM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002460:Cell Line; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000494:pharmacology*; D013343:Styrenes / Q000138:chemical synthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D013343:Styrenes; C080434:goniopypyrone