Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase.
The cellular yes (c-yes) gene is a member of the class of proto-oncogenes that encode non-receptor tyrosine protein kinases. In this report we describe the isolation of cDNAs that encode the murine c-yes gene product and analysis of the nucleotide sequence of the murine c-yes cDNA clones. The reading frame encodes a protein of 541 amino acids with a calculated molecular mass of 60.63 kDa that is reactive with anti-Yes antisera and possesses protein kinase activity.
Klages
S
S
Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543.
Adam
D
D
Eiseman
E
E
Fargnoli
J
J
Dymecki
S M
SM
Desiderio
S V
SV
Bolen
J B
JB
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification*; D016391:Genes, src; D051379:Mice; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D051575:Proto-Oncogene Proteins c-yes; D029867:Xenopus Proteins; D014982:Xenopus laevis; D019061:src-Family Kinases
D011518:Proto-Oncogene Proteins; D029867:Xenopus Proteins; D004247:DNA; D011505:Protein-Tyrosine Kinases; D051575:Proto-Oncogene Proteins c-yes; C496638:YES1 protein, Xenopus; C496639:Yes1 protein, mouse; D019061:src-Family Kinases