Suppression of ventricular premature contractions continues after the washout of antiarrhythmic drugs.
The effects of the washout of antiarrhythmic drugs on the frequency of ventricular premature contraction (VPC) were investigated in 64 patients (VPCs > 2000/day). Included were patients on mexiletine (300-600 mg/day; 23 patients), disopyramide (300-600 mg/day; 19 patients) and atenolol (50 mg/day; 22 patients). Holter monitoring was repeated before, during and after the treatment with the above 3 drugs and the efficacies of the drugs were evaluated based on the spontaneous variability before the treatment. VPC reduction exceeding the calculated spontaneous variability during drugs therapy (drug-responders) and after the washout of the drugs (wash-responders) was noted in 17 (63%) and 3 (13%) of the mexiletine group; 11 (58%) and 5 (26%) of the disopyramide group; and 13 (59%) and 8 (36%) of the atenolol group, respectively. For the entire group of 64 patients, wash-responders were noted significantly (p < 0.05) more among drug-responders (14 of 41 patients; 34%) than drug-nonresponders (2 of 23 patients; 9%). Therefore, the antiarrhythmic effects of drugs observed during drugs therapy seem to continue even after the discontinuation of antiarrhythmic drugs in 34% of patients those whose VPC reduction exceeded the spontaneous variability (drug-responders).
Saikawa
T
T
Department of Internal Medicine, Oita Medical University, Japan.
Ito
M
M
Nakagawa
M
M
Shimoyama
N
N
Hara
M
M
Yonemochi
H
H
Maeda
T
T
Inoue
T
T
Takaki
R
R
Arita
M
M
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001262:Atenolol / Q000493:pharmacokinetics / Q000494:pharmacology; D004206:Disopyramide / Q000493:pharmacokinetics / Q000494:pharmacology; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000493:pharmacokinetics / Q000494:pharmacology; D008875:Middle Aged
D000889:Anti-Arrhythmia Agents; D008801:Mexiletine; D001262:Atenolol; D004206:Disopyramide