Cytological and histological changes in the middle ear after inoculation of influenza A virus.
Experimental otitis media induced in the chinchilla by inoculation of influenza A virus into the middle ear resulted in capillary engorgement, subepithelial hemorrhage, tissue edema and acute inflammatory cell infiltration. Quantitative morphometric measurements were made for 28 days. Ciliated cells appeared to be the primary target of this strain of influenza virus and demonstrated the greatest degree of damage. Three weeks were required to restore the ciliated epithelium in the tubotympanum to normal levels.
Chung
M H
MH
Department of Otolaryngology, Ohio State University College of Medicine, Columbus.
Griffith
S R
SR
Park
K H
KH
Lim
D J
DJ
DeMaria
T F
TF
D000818:Animals; D002682:Chinchilla; D002923:Cilia / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000382:microbiology / Q000473:pathology*; D005064:Eustachian Tube / Q000382:microbiology / Q000473:pathology; D009980:Influenza A virus; D009976:Orthomyxoviridae Infections / Q000150:complications* / Q000473:pathology; D010033:Otitis Media / Q000382:microbiology* / Q000473:pathology*; D014432:Tympanic Membrane / Q000382:microbiology / Q000473:pathology