title: Infectious disease, interleukin-1 and central nervous system.
abstract: Host mediators are responsible for inducing many of the nonspecific, common symptoms of illness. Several of these responses, including the induction of fever, increased levels of glucocorticoid, and increased sleep are mediated by the central nervous system (CNS). Interleukin-1 appears to be an important, but not the only, cytokine involved in activating these processes. Numerous unresolved questions remain regarding cytokine activation of the CNS, such as the neuroanatomical and neurochemical pathways involved in these responses; why these responses vary in magnitude and duration; what are the roles of individual cytokines in inducing these responses during infectious disease.
authors.affiliation: Department of Pharmacology and Therapeutics, University of South Florida College of Medicine.
authors.forename: P E
authors.initials: PE
authors.lastname: Gottschall
mesh_terms: D000210:Acute-Phase Reaction / Q000503:physiopathology*; D002490:Central Nervous System / Q000502:physiology*; D003141:Communicable Diseases / Q000503:physiopathology*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*
chemical_list: D007375:Interleukin-1