title: Complex karyotypic abnormalities including t(8;22) in a patient with chronic lymphocytic leukemia.
abstract: The case of a 49-year-old Chinese man with B-cell chronic lymphocytic leukemia (B-CLL) is presented. Complex karyotypic abnormalities comprising t(8;22)(q24;q11), trisomy 7, a deletion of 11q, and two small marker chromosomes were observed in PWM-stimulated cultures of his peripheral blood cells. To our knowledge, this is the first report of a t(8;22) in CLL.
authors.affiliation: Jiangsu Institute of Hematology, Leukemia Research Unit, Suzhou, Peoples Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
authors.forename: F
authors.initials: F
authors.lastname: Yu
authors.forename: Z
authors.initials: Z
authors.lastname: Zhou
authors.forename: Z
authors.initials: Z
authors.lastname: He
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Lin
mesh_terms: D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic / Q000235:genetics*