Translocation (12;14)(q13;q32) in myelodysplastic syndrome.
We report a patient diagnosed with refractory anemia with excess blasts in transformation (RAEB-t) who underwent an evolution to a nonlymphocytic acute leukemia (ANLL-M5a). Initial cytogenetic study showed a diploid karyotype; however, when ANLL-M5a was diagnosed, the bone marrow (BM) cells showed a t(12;14)(q13;q32), which to our knowledge has not been described previously in a myelodysplastic syndrome (MDS).
Badía
L
L
Unidad de Genética Hospital Universitario La Fe, Valencia, Spain.
Alvarez
M A
MA
Palau
F
F
Prieto
F
F
D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications / Q000235:genetics*; D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000235:genetics; D011519:Proto-Oncogenes; D014178:Translocation, Genetic