Pathology induced by interleukin-6.
Interleukin-6 (IL-6) is a multifunctional cytokine that plays an important role in the immune response, hemopoiesis, and host defense. Recombinant human IL-6 (rhIL-6) was administered at high doses to mice, rats, and nonhuman primates. In all species, IL-6 had an immunostimulatory and hemopoietic (especially on megakaryocytes) effect. An acute-phase response was most pronounced in nonhuman primates, which was, however, not associated with any significant histopathological liver change. Finally, no evidence of glomerular pathology was found. Neutralizing antibodies were detected within 10 days of rhIL-6 administration in all species.
Ryffel
B
B
Institut für Toxikologie, Eidgenössischen Technischen Hochschule Universität Zürich, Switzerland.
Mihatsch
M J
MJ
Woerly
G
G
D000210:Acute-Phase Reaction / Q000139:chemically induced; D000818:Animals; D005260:Female; D005472:Fluorouracil / Q000633:toxicity; D006402:Hematologic Diseases / Q000139:chemically induced / Q000473:pathology; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D015850:Interleukin-6 / Q000627:therapeutic use / Q000633:toxicity*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D051379:Mice; D008807:Mice, Inbred BALB C; D010198:Pancytopenia / Q000139:chemically induced / Q000628:therapy; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000627:therapeutic use / Q000633:toxicity; D013045:Species Specificity
D007155:Immunologic Factors; D015850:Interleukin-6; D011994:Recombinant Proteins; D005472:Fluorouracil