Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia.
A translocation (6;11)(q26-27;q23) was detected in four male patients diagnosed with acute T-cell lymphoblastic leukemia and acute myelomonocytic and monocytic leukemias. This acquired reciprocal translocation appears to be associated with acute leukemias in young men who present clinically with localized infection, and a moderate leukocytosis. There was a poor response to antileukemic chemotherapy and a short overall survival. Aggressive treatment strategies should be considered in the treatment of these high-risk leukemias.
Welborn
J L
JL
Department of Internal Medicine, University of California, Davis, Sacramento 95816.
Jenks
H M
HM
Hagemeijer
A
A
D000293:Adolescent; D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic / Q000235:genetics*