title: [A resected case of leiomyosarcoma of the esophagus--the diagnosis was supported with DNA content analysis].
abstract: A case of leiomyosarcoma of the esophagus was reported. The tumor was located in the lower esophagus. The esophagus was very stenotic, but the mucosa was clear. We thought the tumor had not invaded the mucosa. Enucleation was performed on the tumor. The tumor was encapsulated, so at the time of operation, the microscopic diagnosis was leiomyoma. However, after the operation, the diagnosis was changed to the leiomyosarcoma, because there are many spindle-shaped atypical cells, and many mitoses. We also analyzed the DNA content of the tumor. The DNA index of this tumor was 0.9 and 1.48, therefore, this tumor was DNA aneuploidy. The result of DNA content analysis showed that the tumor is malignant. DNA content analysis is helpful for diagnosis of this kind of sarcoma, because microscopic examination can not readily distinguish benign leiomyoma from malignant leiomyosarcoma. This patient was still alive one year after the operation. Thus, we thought that enucleation of the tumor is a good operational procedure to the leiomyosarcoma of the esophagus, if the tumor is polypoid type and encapsulated.
authors.affiliation: Respiratory Disease Center, Kyoto Katsura Hospital, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Chiba
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: S
authors.initials: S
authors.lastname: Sawai
authors.forename: R
authors.initials: R
authors.lastname: Hatakenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Matsubara
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D005434:Flow Cytometry; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008875:Middle Aged
chemical_list: D004273:DNA, Neoplasm