title: Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. The National Polyp Study Workgroup.
abstract: BACKGROUND
  The identification and removal of adenomatous polyps and post-polypectomy surveillance are considered to be important for the control of colorectal cancer. In current practice, the intervals between colonoscopies after polypectomy are variable, often a year long, and not based on data from randomized clinical trials. We sought to determine whether follow-up colonoscopy at three years would detect important colonic lesions as well as follow-up colonoscopy at both one and three years.
  
  
  METHODS
  Patients were eligible if they had one or more adenomas, no previous polypectomy, and a complete colonoscopy and all their polyps had been removed. They were randomly assigned to have follow-up colonoscopy at one and three years or at three years only. The two study end points were the detection of any adenoma, and the detection of adenomas with advanced pathological features (defined as those > 1 cm in diameter and those with high-grade dysplasia or invasive cancer).
  
  
  RESULTS
  Of 2632 eligible patients, 1418 were randomly assigned to the two follow-up groups, 699 to the two-examination group and 719 to the one-examination group. The percentage of patients with adenomas in the group examined at one and three years was 41.7 percent, as compared with 32.0 percent in the group examined at three years (P = 0.006). The percentage of patients with adenomas with advanced pathological features was the same in both groups (3.3 percent).
  
  
  CONCLUSIONS
  Colonoscopy performed three years after colonoscopic removal of adenomatous polyps detects important colonic lesions as effectively as follow-up colonoscopy after both one and three years. An interval of at least three years is recommended before follow-up colonoscopy after both one and three years. An interval of at least three years is recommended before follow-up examination after colonoscopic removal of newly diagnosed adenomatous polyps. Adoption of this recommendation nationally should reduce the cost of post-polypectomy surveillance and screening.
authors.affiliation: Gastroenterology and Nutrition Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
authors.forename: S J
authors.initials: SJ
authors.lastname: Winawer
authors.forename: A G
authors.initials: AG
authors.lastname: Zauber
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Brien
authors.forename: M N
authors.initials: MN
authors.lastname: Ho
authors.forename: L
authors.initials: L
authors.lastname: Gottlieb
authors.forename: S S
authors.initials: SS
authors.lastname: Sternberg
authors.forename: J D
authors.initials: JD
authors.lastname: Waye
authors.forename: J
authors.initials: J
authors.lastname: Bond
authors.forename: M
authors.initials: M
authors.lastname: Schapiro
authors.forename: E T
authors.initials: ET
authors.lastname: Stewart
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003111:Colonic Polyps / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D003113:Colonoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011230:Precancerous Conditions; D012307:Risk Factors