title: Enhancement of water intake in rats after lidocaine injection in the zona incerta.
abstract: Physiological evidence indicates that the zona incerta (ZI) may be an important region for convergence of signals mediating drinking. It is known that the ZI receives neural influences from brain osmoreceptive zones. Also there are wide-spread projections from the ZI to the neocortex. In the present experiments, lidocaine (1 microliter, 20 ng/microliters) was injected into the rostral aspect of the ZI. The animals were previously stimulated for water drinking by: a) overnight water deprivation; b) 2 M NaCl IP; c) AII (50 ng) in the anteroventral wall of the third ventricle (AV3V). In every case, lidocaine administration significantly enhanced the volume of water drank. The results support the idea that ZI exerts an inhibitory influence upon the expression of drinking behavior.
authors.affiliation: Instituto de Investigación Médica, Mercedes y Martín Ferreyra, Cordoba, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Tonelli
authors.forename: E
authors.initials: E
authors.lastname: Chiaraviglio
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000502:physiology; D003681:Dehydration / Q000503:physiopathology; D004326:Drinking / Q000187:drug effects* / Q000502:physiology; D007267:Injections; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon; D009995:Osmosis; D051381:Rats; D012154:Reticular Formation / Q000502:physiology*; D012527:Satiation; D014868:Water Deprivation
chemical_list: D000804:Angiotensin II; D008012:Lidocaine