Quantitative 31P MRS of the normal adult human brain. Assessment of interindividual differences and ageing effects.
The characteristics of the 31P MR spectra from a large central volume in the brain of 47 healthy adults (aged 25-85 years) were assessed. Spectral parameters were estimated by means of a time-domain fitting technique. Statistical uncertainties of the estimates were determined by means of the Cramer-Rao theory and minimized by introducing a priori knowledge into the fitting procedure. Age-dependency of the spectral parameters was assessed by means of linear regression. Significant differences between individuals were established for some parameters. A significant age-dependency (p < or = 0.001) of ca 20% over the age range considered was found for the intensity of the phosphocreatine resonance line.
Longo
R
R
Istituto di Radiologia, Università degli Studi di Trieste, Ospedale di Cattinara, Trieste, Italy.
Ricci
C
C
Dalla Palma
L
L
Vidimari
R
R
Giorgini
A
A
den Hollander
J A
JA
Segebarth
C M
CM
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007206:Individuality; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*
D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate