Estrogen receptor variant and hypertension in women.
Eighty-eight women visiting a gynecologist were tested for an estrogen receptor B-variant allele. The women were ethnically and racially homogeneous to a large degree. They were from a suburb of Long Island, and most were white. The 12% incidence of hypertension in women with the estrogen receptor wild-type allele is comparable to the 13-32% incidence in the general population of women aged 55-64 years. However, the 48% incidence of hypertension in women with the estrogen receptor B-variant allele is considerably higher than in the general population of women in this age group. We conclude that the presence of the estrogen receptor B-variant allele might have increased the prevalence of hypertension in the women in this study.
Lehrer
S
S
Department of Radiation Therapy, Mount Sinai Medical Center, New York, NY 10029.
Rabin
J
J
Kalir
T
T
Schachter
B S
BS
D000367:Age Factors; D000483:Alleles; D015992:Body Mass Index; D005260:Female; D014644:Genetic Variation; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D015994:Incidence; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000235:genetics*; D012737:Sex Factors
D011960:Receptors, Estrogen