The effect of microvascular anastomosis configuration on initial platelet deposition.
The propensity for platelets to bind at a native vessel anastomosis is thought to be related to subendothelial exposure, the presence of suture material, and local flow disturbances. By using an artificial microvascular graft to artificial microvascular graft anastomosis model that mimics the geometry and topography of a native microvascular anastomosis but which eliminates the endothelial and subendothelial contributions, the influence of the normal anastomotic configuration alone on initial platelet deposition was measured. Anastomotic and immediate downstream platelet deposition was not augmented by the presence of the anastomotic configuration alone. This suggests that the enhanced initial platelet deposition in the region of a native vessel microanastomosis is primarily related to the presence of injured endothelium and exposed subendothelium rather than to flow disturbances.
Johnson
P C
PC
Department of Surgery, University of Pittsburgh School of Medicine, Pa.
Dickson
C S
CS
Garrett
K O
KO
Sheppeck
R A
RA
Bentz
M L
ML
D000714:Anastomosis, Surgical / Q000379:methods*; D001807:Blood Vessel Prosthesis; D004338:Drug Combinations; D006490:Hemostatics / Q000737:chemistry; D006801:Humans; D007205:Indium Radioisotopes; D008855:Microscopy, Electron, Scanning; D008866:Microsurgery / Q000379:methods*; D008955:Models, Cardiovascular; D010168:Palmitates / Q000737:chemistry; D010973:Platelet Adhesiveness / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology*; D010976:Platelet Count; D011138:Polytetrafluoroethylene / Q000737:chemistry; D012212:Rheology; D013499:Surface Properties; D014885:Waxes / Q000737:chemistry
D004338:Drug Combinations; D006490:Hemostatics; D007205:Indium Radioisotopes; D010168:Palmitates; D014885:Waxes; C055480:bone wax; D011138:Polytetrafluoroethylene