title: Breast cancer risk associated with proliferative breast disease and atypical hyperplasia.
abstract: BACKGROUND
  Women with proliferative breast disease (PD) have been observed to have an increased risk of breast cancer. The authors evaluated the effect of PD on breast cancer risk in a case-control study among participants of the Breast Cancer Detection Demonstration Project (BCDDP).
  
  
  METHODS
  More than 280,000 women were screened in the BCDDP at 29 centers. Study subjects were selected from BCDDP participants who underwent biopsy that revealed benign breast tissue. There were five BCDDP centers for which histologic slides were available on more than 85% of the benign biopsy specimens. Case patients for this study were the 95 women from these five centers who had breast cancer develop during follow-up. Two matched control patients who did not have breast cancer develop were selected for each case. The biopsy slides were reviewed by two pathologists who were blinded with regard to cancer outcome.
  
  
  RESULTS
  Women with atypical hyperplasia (AH) had 4.3 times the breast cancer risk of women without PD (95% confidence interval [CI], 1.7-11). In women with PD lacking AH, the relative risk was 1.3 (95% CI, 0.77-2.2). A family history of breast cancer (FH) increased breast cancer risk 2.4 times (95% CI, 1.4-4.3). The joint occurrence of FH and AH had a strong synergistic effect on breast cancer risk.
  
  
  CONCLUSIONS
  AH is a reliable marker of increased breast cancer risk among women undergoing breast biopsy.
authors.affiliation: Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2637.
authors.forename: W D
authors.initials: WD
authors.lastname: Dupont
authors.forename: F F
authors.initials: FF
authors.lastname: Parl
authors.forename: W H
authors.initials: WH
authors.lastname: Hartmann
authors.forename: L A
authors.initials: LA
authors.lastname: Brinton
authors.forename: A C
authors.initials: AC
authors.lastname: Winfield
authors.forename: J A
authors.initials: JA
authors.lastname: Worrell
authors.forename: P A
authors.initials: PA
authors.lastname: Schuyler
authors.forename: W D
authors.initials: WD
authors.lastname: Plummer
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000150:complications*; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics; D002114:Calcinosis / Q000473:pathology; D002278:Carcinoma in Situ / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia; D008327:Mammography; D008403:Mass Screening; D008593:Menopause; D008875:Middle Aged; D012307:Risk Factors