Possible interaction between fluoxetine and pimozide causing sinus bradycardia.
Fluoxetine has been reported to have interactions with antipsychotics and other antidepressants with symptoms of toxicity of these drugs. We report a case of a possible interaction with pimozide which led to a potentially life threatening bradycardia. Careful monitoring should be done when these two drugs are prescribed at the same time, especially in the elderly and in patients with cardiac disease.
Ahmed
I
I
Department of Psychiatry, John A. Burns School of Medicine, University of Hawaii.
Dagincourt
P G
PG
Miller
L G
LG
Shader
R I
RI
D000368:Aged; D001146:Arrhythmia, Sinus / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced*; D003702:Delusions / Q000188:drug therapy / Q000523:psychology; D003704:Dementia / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D010259:Paranoid Disorders / Q000188:drug therapy / Q000523:psychology; D010868:Pimozide / Q000009:adverse effects* / Q000627:therapeutic use
D005473:Fluoxetine; D010868:Pimozide