Antitumor effect of a mycotoxin: rubratoxin B.
The antitumor effect of rubratoxin B, a mycotoxin, has been studied. Yoshida ascites sarcoma cells, in vitro in contact for 30 min with the drug and injected immediately afterwards into young rats by the intraperitoneal route, produced the survival of 80% of the animals and the doubling of the median survival time of the rats developing neoplasia. In vivo administration of the drug by the intraperitoneal route 24 h after implantation of tumor cells determined the prolongation of median survival time; supplied by other routes both against T8 sarcoma of Guérin and Yoshida ascites sarcoma it was ineffective. The differences between in vitro and in vivo results can be explained by a rapid neutralization of the drug on behalf of the organism's enzymes or by being bound to proteins and peritoneal cells unlike tumor cells.
Fimiani
V
V
Institute of General Pathology School of Medicine, University of Messina, Italy.
Richetti
A
A
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009183:Mycotoxins / Q000627:therapeutic use* / Q000633:toxicity; D009368:Neoplasm Transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012517:Sarcoma, Yoshida / Q000188:drug therapy*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D009183:Mycotoxins; C100297:rubratoxins