Calcium kinetics in the hyperprostaglandin E syndrome.
Metabolic investigations, including the use of stable isotopes of calcium, were used to study calcium kinetics in three children with the hyperprostaglandin E syndrome. The studies were performed both during indomethacin treatment and in the absence of therapy. Off therapy, each child had hypercalciuria (mean urinary calcium excretion 0.478 mM/kg/d), hyperprostaglandinuria, and elevated serum calcitriol concentration. All had diminished bone density and were euparathyroid. Indomethacin treatment was associated with a marked reduction in serum calcitriol concentration, as well as decreased prostaglandin E excretion. Mean urinary calcium excretion fell to 0.135 mM/kg/d. The stable isotope studies defined two components to the hypercalciuria of this disease: an indomethacin-sensitive dietary contribution and a relatively indomethacin-resistant bone resorptive element. Bone densitometry confirmed the presence of the resorptive element by demonstrating skeletal demineralization.
Shoemaker
L
L
Department of Pediatrics, University of Cincinnati College of Medicine, Ohio 45229.
Welch
T R
TR
Bergstrom
W
W
Abrams
S A
SA
Yergey
A L
AL
Vieira
N
N
D015519:Bone Density; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D002127:Calcium Isotopes; D002136:Calcium, Dietary / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D009397:Nephrocalcinosis / Q000188:drug therapy / Q000378:metabolism; D011458:Prostaglandins E / Q000652:urine*; D013577:Syndrome
D002127:Calcium Isotopes; D002136:Calcium, Dietary; D011458:Prostaglandins E; D002118:Calcium; D007213:Indomethacin