In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues.
The in vitro metabolism of [1,2-3H] deoxycorticosterone (DOC), [1,2-3H] 18-hydroxy-11-deoxycorticosterone (18-OHDOC) and [1,2-3H] 11-deoxycortisol (S) was studied in adrenal adenoma homogenates from patients with primary hyperaldosteronism. Tumor tissues actively converted deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone to 18-hydroxycorticosterone and aldosterone. Yields of cortisol and cortisone were also large showing that the tissues did not lack the zona fasciculata-like 11 beta-hydroxylation ability.
Bogdan
A
A
Biochemical Department, Faculté de Médecine Pitié, Paris, France.
Auzéby
A
A
Plouin
P F
PF
Touitou
Y
Y
D015069:18-Hydroxycorticosterone / Q000378:metabolism; D015070:18-Hydroxydesoxycorticosterone / Q000378:metabolism; D000236:Adenoma / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D000450:Aldosterone / Q000096:biosynthesis; D003348:Cortisone / Q000096:biosynthesis; D003350:Cortodoxone / Q000378:metabolism; D003900:Desoxycorticosterone / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000096:biosynthesis*; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis; D006929:Hyperaldosteronism / Q000378:metabolism*; D008297:Male; D008901:Mineralocorticoids / Q000096:biosynthesis*
D015070:18-Hydroxydesoxycorticosterone; D005938:Glucocorticoids; D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D003348:Cortisone; D003350:Cortodoxone; D006854:Hydrocortisone