title: t(5;12)(q31;p12). A clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia.
abstract: We report two patients with a myeloproliferative disorder (Philadelphia chromosome-negative chronic myeloid leukemia) and t(5;12)(q31;p12). Until now, only three cases of a translocation (5;12)(q31;p12) have been reported. All investigators had problems classifying their patient's disease into one of the well-defined entities of either MPD or myelodysplastic disorders. We postulate that this translocation may represent a subgroup of patients with features of both chronic myeloid leukemia and chronic myelomonocytic leukemia (CMMoL).
authors.affiliation: Department of Human Genetics, State University, Leiden, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Wessels
authors.forename: W E
authors.initials: WE
authors.lastname: Fibbe
authors.forename: D
authors.initials: D
authors.lastname: van der Keur
authors.forename: J E
authors.initials: JE
authors.lastname: Landegent
authors.forename: D C
authors.initials: DC
authors.lastname: van der Plas
authors.forename: G J
authors.initials: GJ
authors.lastname: den Ottolander
authors.forename: K J
authors.initials: KJ
authors.lastname: Roozendaal
authors.forename: G C
authors.initials: GC
authors.lastname: Beverstock
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002881:Chromosomes, Human, Pair 12; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics*; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic