U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model.
Thermal energy causes an immediate, irreversible injury at the burn site, followed by a delayed, reversible tissue loss in the area surrounding the burn site due to progressive ischemia. We investigated the role of lipid peroxidation in the pathogenesis of progressive ischemia in a rat burn model. The burn model consisted of a row of four 10 x 20 mm burns separated by three unburned 5 x 20 mm skin bridges (interspaces). The interspaces became ischemic and necrotic by 24 hours, producing a single wound with the merger of the burn sites. U75412E, a lipid peroxidation inhibitor, preserved vascular patency, restored blood flow, prevented a rise in tissue conjugated dienes, and maintained tissue viability in the interspaces. Four separate burn wounds healed between three viable strips of hair-bearing interspaces. The treatment was effective, when given systemically during the period between 2 hours before and 1 hour after the burn. U75412E prevented progressive burn ischemia and the expansion of tissue loss.
Choi
M
M
Wound Healing Laboratory, Shriners Burns Institute, Massachusetts General Hospital, Harvard Medical School, Boston 02142.
Ehrlich
H P
HP
D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D002056:Burns / Q000150:complications* / Q000473:pathology; D007511:Ischemia / Q000517:prevention & control*; D007840:Latex; D008297:Male; D008953:Models, Anatomic; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000293:injuries* / Q000473:pathology; D013256:Steroids / Q000494:pharmacology*
D007840:Latex; D013256:Steroids; C069980:U 75412E