Generation of cytotoxic agents by targeted enzymes.
Senter
P D
PD
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121.
Wallace
P M
PM
Svensson
H P
HP
Vrudhula
V M
VM
Kerr
D E
DE
Hellström
I
I
Hellström
K E
KE
D000469:Alkaline Phosphatase / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000627:therapeutic use; D004337:Drug Carriers; D057487:Enzyme Therapy; D004798:Enzymes / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D011355:Prodrugs / Q000378:metabolism* / Q000627:therapeutic use; D011623:gamma-Glutamyl Hydrolase / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D004337:Drug Carriers; D004798:Enzymes; D011355:Prodrugs; D000469:Alkaline Phosphatase; D011623:gamma-Glutamyl Hydrolase