Frequent presence of anti-GQ1b antibody in Fisher's syndrome.
We used the enzyme-linked immunosorbent assay to investigate autoantibodies against the gangliosides GM1, GD1a, GD1b, GT1b, GD2, and GQ1b in sera from 16 patients with Fisher's syndrome. We found high anti-GQ1b antibody titers, mainly those of the IgG class, in the sera of 13 of these patients. The titers decreased with the clinical course of the illness. Moreover, anti-GQ1b antibody-positive patients had more severe ataxia of cerebellar type than the antibody-negative patients.
Yuki
N
N
Department of Neurology, Niigata University, Japan.
Sato
S
S
Tsuji
S
S
Ohsawa
T
T
Miyatake
T
T
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000276:immunology*
D001323:Autoantibodies; D005732:Gangliosides; C039129:GQ1b ganglioside