title: Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis.
abstract: Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4-hydroxy-L-threonine. This observation constitutes the first direct evidence in support of the view that 4-hydroxy-L-threonine is implicated in the biosynthesis of vitamin B6. 1-Aminopropan-2,3-diol, the decarboxylation product of 4-hydroxy-L-threonine, does not support the growth of these mutants. Deuterium from deuterium-labelled 1-aminopropan-2,3-diol was not incorporated into pyridoxol.
authors.affiliation: Institut für Pharmazeutische Biologie, Universität Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Drewke
authors.forename: C
authors.initials: C
authors.lastname: Notheis
authors.forename: U
authors.initials: U
authors.lastname: Hansen
authors.forename: E
authors.initials: E
authors.lastname: Leistner
authors.forename: T
authors.initials: T
authors.lastname: Hemscheidt
authors.forename: R E
authors.initials: RE
authors.lastname: Hill
authors.forename: I D
authors.initials: ID
authors.lastname: Spenser
mesh_terms: D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D011736:Pyridoxine / Q000096:biosynthesis*; D013912:Threonine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: C011285:hydroxythreonine; D013912:Threonine; D011736:Pyridoxine