Prenatal alcohol exposure attenuates pentylenetetrazol-induced convulsions in rats.
Female rats prenatally exposed to alcohol were tested at 35 days of age for susceptibility to pentylenetetrazol (PTZ)-induced convulsions. There was a significant dose-response effect of PTZ. Contrary to expectations, alcohol-exposed females were slightly but still significantly less convulsion-prone than pair-fed controls. These results suggest prenatal alcohol exposure reduces the susceptibility to convulsions in rats.
Abel
E L
EL
Department of Obstetrics/Gynecology, Wayne State University, Detroit, MI.
Berman
R F
RF
Church
M W
MW
D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D010433:Pentylenetetrazole / Q000008:administration & dosage; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced*
D000431:Ethanol; D010433:Pentylenetetrazole