title: High-frequency phenotypic switching in Candida albicans.
abstract: Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.
authors.affiliation: Department of Biological Sciences, University of Iowa, Iowa City 52242-1324.
authors.forename: D R
authors.initials: DR
authors.lastname: Soll
authors.forename: B
authors.initials: B
authors.lastname: Morrow
authors.forename: T
authors.initials: T
authors.lastname: Srikantha
mesh_terms: D000940:Antigenic Variation / Q000235:genetics*; D000946:Antigens, Fungal / Q000235:genetics*; D002176:Candida albicans / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity / Q000648:ultrastructure; D005656:Fungal Proteins / Q000096:biosynthesis / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D010641:Phenotype; D014158:Transcription, Genetic; D014774:Virulence
chemical_list: D000946:Antigens, Fungal; D005656:Fungal Proteins