title: [A clinical multivariate study on bone change after parathyroidectomy in patients with renal osteodystrophy].
abstract: This study investigated the changes of bone lesions after parathyroidectomy (PTX) in patients with renal osteodystrophy. Fifty-eight patients (mean age 43.7 +/- 8.4 years and mean duration of hemodialysis 120.9 +/- 32.1 months), who were resistant to medical treatments, were studied. Total PTX was followed by massive administration of alfacalcidol on these patients. The clinical symptoms, hematological findings, radiographic findings and second metacarpal bone density during the first 2 years following PTX were studied. After the operation, the clinical symptoms, hematological findings as well as radiographic findings improved in all of the patients and the density of the second metacarpal bone increased in 37 out of 40 patients. From these results we concluded that total PTX followed by massive administration of active vitamin D was effective in improving bone lesions and bone mineral density on patients with renal osteodystrophy.
authors.affiliation: Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Denda
authors.forename: K
authors.initials: K
authors.lastname: Kushida
mesh_terms: D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016105:Parathyroidectomy; D011184:Postoperative Period; D011859:Radiography
chemical_list: D006887:Hydroxycholecalciferols; C008088:alfacalcidol