Dynamic test with recombinant interferon-alpha-2b: effect on 90K and other tumour-associated antigens in cancer patients without evidence of disease.
We have previously shown that a short course of recombinant interferon-alpha-2b (rIFN-alpha-2b) (3 million units day for 5 days) for patients with primary gynaecologic malignancies was able to increase the circulating levels of a newly discovered tumour associated antigen, termed 90K. In this study, we have investigated the effects of the same modality of administration of rIFN-alpha-2b in 62 patients with breast and colorectal cancer whose primary tumour was surgically removed 1 month before and who were without evidence of disease (NED) at the time of the study. A significant increase of 90K serum concentration was already observed 24 h after the first r-IFN-alpha-2b injection and persisted throughout the investigational period. The increase was more pronounced in patients with a basal 90K-negative than a 90K-positive assay. Of 54 patients who started the test with a 90K negative assay, 17 (31%) shifted to a positive assay after rIFN-alpha-2b. Twenty-eight of 62 (45%) patients exhibited a 90K value above the mean increment of the whole population. The serum levels of CEA, CA-15-3, CA 19-9, and alpha-fetoprotein measured in the same serum samples were not modified. After 2 years of follow-up, ten patients relapsed. Six of them showed a 90K increase above the mean increment of the whole population. As with ovarian cancer, the increase of 90K following r-IFN-alpha-2b administration might be of importance for the early detection of disease recurrence in clinically NED breast and colon cancer patients.
Natoli
C
C
Cattedra di Oncologia Medica, Università G. D'Annunzio, Chieti, Italy.
Garufi
C
C
Tinari
N
N
D'Egidio
M
M
Lesti
G
G
Gaspari
L A
LA
Visini
R
R
Iacobelli
S
S
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood* / Q000187:drug effects; D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000097:blood / Q000276:immunology*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D011994:Recombinant Proteins
D015295:Antigens, Tumor-Associated, Carbohydrate; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins