[Effect of Y-25130 on gastric motility in anesthetized rats].
We developed an automatic analyzing system using a personal computer to evaluate gastric motility objectively. Gastric motility was divided into three elements: motility index, amplitude and frequency. These elements analyzed with both computer and manual methods closely correlated with each other (R2 = 0.943, 0.985 and 0.986, respectively). The effect of Y-25130 on gastric motility was investigated in anesthetized rats with the automatic analyzing system. Intravenous administration of Y-25130 increased both spontaneous and cisplatin-reduced gastric motility. The effect of Y-25130 on spontaneous motility was superior to that of ondansetron and metoclopramide, and the effect on cisplatin-reduced motility was almost the same as that of ondansetron and superior to that of metoclopramide. In vagotomized rats, Y-25130 did not increase the gastric motility not only in spontaneous conditions but also in efferent vagus stimulated conditions. Atropine completely blocked the gastric motility induced by Y-25130. In capsaicin pre-treated rats, Y-25130 had no effect. On the other hand, Y-25130 increased the gastric motility induced by afferent vagus stimulation. These results suggest that Y-25130 increases gastric motility through the vagus nerve and acts on afferent neurons.
Odani
N
N
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka, Japan.
Haga
K
K
Setoguchi
M
M
D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002211:Capsaicin / Q000494:pharmacology; D004558:Electric Stimulation; D015905:Gastric Balloon; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D017294:Ondansetron / Q000494:pharmacology; D010078:Oxazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*
D000932:Antiemetics; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010078:Oxazines; D011985:Receptors, Serotonin; D017294:Ondansetron; C070671:azasetron; D001285:Atropine; D008787:Metoclopramide; D002211:Capsaicin