title: Platelet monoamine oxidase B activity in Parkinson's disease: a re-evaluation.
abstract: An increase in platelet monoamine oxidase (MAO) B activity in drug-free parkinsonians (n = 6) compared with healthy controls (n = 10) has been confirmed using both phenylethylamine (PEA) and dopamine as substrates, reaching statistical significance in the case of PEA oxidising activity (p < 0.05). Thus, certain reports of raised platelet MAO B activity towards PEA but decreased activity towards dopamine in parkinsonians, raising the possibility of the existence of an abnormal form of MAO B in this condition, cannot be supported.
authors.affiliation: School of Life Sciences, Kingston University, Kingston upon Thames, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Jarman
authors.forename: V
authors.initials: V
authors.lastname: Glover
authors.forename: M
authors.initials: M
authors.lastname: Sandler
authors.forename: N
authors.initials: N
authors.lastname: Turjanski
authors.forename: G
authors.initials: G
authors.lastname: Stern
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010300:Parkinson Disease / Q000201:enzymology*; D010627:Phenethylamines / Q000378:metabolism
chemical_list: D010627:Phenethylamines; C029261:phenethylamine; D008995:Monoamine Oxidase; D004298:Dopamine