title: Profiles of language impairment in primary progressive aphasia.
abstract: OBJECTIVE
  The profile of language impairment in patients with primary progressive aphasia in comparison with the language impairment in patients with Alzheimer's disease and after stroke.
  
  
  METHODS
  The Western Aphasia Battery and the Mattis Dementia Rating Scale evaluated the language and cognitive impairment. Follow-up studies were done 1 to 5 years after the initial testing in seven of 10 patients with primary progressive aphasia, and a postmortem examination of the brain was done in two patients.
  
  
  METHODS
  All 10 patients with primary progressive aphasia were previously healthy, community-dwelling persons when first tested.
  
  
  METHODS
  All patients with primary progressive aphasia reported at least a 2-year history of slowly progressive aphasia without other signs of global dementia. The initial Western Aphasia Battery results of the 10 patients with primary progressive aphasia were compared with those of a sample of 10 patients with probable Alzheimer's disease and with those of a sample of 10 patients with aphasia due to a left hemispheric stroke. Both reference samples were matched for age and sex; the sample with stroke-caused aphasia was additionally matched for the aphasia type.
  
  
  RESULTS
  Expressive language disability with reduced speech fluency and anomia but preserved language comprehension and nonverbal cognition were typical features in early stages of primary progressive aphasia. Spontaneous speech was significantly more impaired in patients with primary progressive aphasia in comparison with those with aphasia after left hemisphere stroke and with language impairment in patients with Alzheimer's disease. Follow-up examinations revealed continuous, often rapid deterioration of language impairment. The neuropathological examination showed Alzheimer's disease in one patient and Pick's disease in the other.
  
  
  CONCLUSIONS
  The profile of aphasia suggests that primary progressive aphasia tends to affect anterior parts of the language-dominant cortex first.
authors.affiliation: Department of Neurological Sciences, University of Western Ontario, St Joseph's Hospital, London, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Karbe
authors.forename: A
authors.initials: A
authors.lastname: Kertesz
authors.forename: M
authors.initials: M
authors.lastname: Polk
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000523:psychology; D001037:Aphasia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000523:psychology*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002545:Brain Ischemia / Q000523:psychology; D002561:Cerebrovascular Disorders / Q000469:parasitology; D003704:Dementia / Q000523:psychology; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D014057:Tomography, X-Ray Computed