Crystalglobulinemia syndrome. A manifestation of multiple myeloma.
BACKGROUND
Crystalglobulinemia syndrome (CS) is a rare vasculopathy that may arise as a complication of multiple myeloma (MM).


RESULTS
A patient with multiple myeloma in whom crystalglobulinemia syndrome was the initial manifestation with polyarthralgias, cutaneous ulceration, and lower limb ischemia requiring bilateral amputations is reported.


CONCLUSIONS
The rare syndrome of crystalglobulinemia may be associated with multiple myeloma, so it is important that clinicians be aware of this syndrome and its clinical and morphologic features.
Ball
N J
NJ
Department of Pathology, University of Calgary, Alberta, Canada.
Wickert
W
W
Marx
L H
LH
Thaell
J F
JF
D002196:Capillaries / Q000473:pathology; D003460:Crystallization; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular / Q000473:pathology; D016523:Foot Ulcer / Q000473:pathology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000473:pathology*; D007074:Immunoglobulin G / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D013577:Syndrome
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains