title: HLA antigen frequencies in renal transplant recipients and non-immunosuppressed patients with non-melanoma skin cancer.
abstract: An increased frequency of human leukocyte antigen (HLA)-DR1 was found in 49 non-immunosuppressed patients with non-melanoma skin cancer (NMSC), being highest in patients under the age of 60 with multiple squamous cell carcinomas (SCC). Of 266 patients receiving long-term immunosuppression following renal transplantation 46 (17%) were found to have NMSC. No increase in HLA-DR1 was found in renal transplant recipients (RTR) with non-melanoma skin cancer (RTR+C) when compared with matched renal transplant recipients without skin cancer (matched RTR-C), or when compared with healthy controls. There was an increased frequency of DQw2 in RTR+C, most pronounced in RTR with SCC (61.9% compared with 18.75% in matched RTR-C), giving a relative risk of 13.98. We found statistically significant differences in the frequency of a number of HLA antigens on comparing RTR+C with healthy controls, but none of these differences were found when we compared RTR+C against matched RTR-C.
authors.affiliation: Department of Dermatology, Royal London Hospital, U.K.
authors.forename: M T
authors.initials: MT
authors.lastname: Glover
authors.forename: J
authors.initials: J
authors.lastname: Bodmer
authors.forename: W
authors.initials: W
authors.lastname: Bodmer
authors.forename: L J
authors.initials: LJ
authors.lastname: Kennedy
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: C
authors.initials: C
authors.lastname: Navarrete
authors.forename: J T
authors.initials: JT
authors.lastname: Kwan
authors.forename: I M
authors.initials: IM
authors.lastname: Leigh
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D002280:Basal Cell Carcinoma / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis; D015798:HLA-DR1 Antigen / Q000032:analysis; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D006680:HLA Antigens; D006683:HLA-DQ Antigens; D015798:HLA-DR1 Antigen