title: Use of alfentanil with propofol for nasotracheal intubation without neuromuscular block.
abstract: We have investigated the effect of augmentation of propofol with alfentanil for nasotracheal intubation without neuromuscular block in 60 patients undergoing short elective maxillo-facial procedures as outpatients. After administration of glycopyrronium 5 micrograms kg-1 i.v., anaesthesia was induced with propofol 2.5 mg kg-1, or alfentanil 20 micrograms kg-1 and propofol 2.5 mg kg-1. The alfentanil group had improved jaw relaxation (P < 0.001) and vocal cord conditions (P < 0.005). Tracheal intubation was successful in 83% of patients receiving alfentanil, and in 73% of patients receiving propofol only. This difference was not significant. The cardiovascular response to intubation was attenuated in the alfentanil group.
authors.affiliation: Department of Anaesthesia, Walton Hospital, Liverpool.
authors.forename: S F
authors.initials: SF
authors.lastname: Coghlan
authors.forename: P F
authors.initials: PF
authors.lastname: McDonald
authors.forename: G
authors.initials: G
authors.lastname: Csepregi
mesh_terms: D000293:Adolescent; D000328:Adult; D015760:Alfentanil; D000771:Anesthesia, Intravenous; D004357:Drug Synergism; D005145:Face / Q000601:surgery; D006801:Humans; D007442:Intubation, Intratracheal; D008875:Middle Aged; D056948:Orthognathic Surgical Procedures; D015742:Propofol
chemical_list: D015760:Alfentanil; D015742:Propofol