Reduction in primary nonfunction of pancreas islet transplants with antithymocyte globulin agents, deoxyspergualin, and splenectomy.
These results suggest that DSG and RATG are an especially favored combination in reducing PNF of discordant pig islet xenografts, probably related to the effect of DSG on the macrophage, humoral antibody, or blockade of NK cell activity. More effective immunosuppression such as demonstrated in this study could well be critical in permitting the application on discordant islet xenografts to human clinical diabetes.
Pittman
K
K
Department of Surgery, East Carolina University School of Medicine, Greenville, North Carolina.
Thomas
F
F
McFadden
T
T
Haisch
C
C
Thomas
J
J
D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006736:Horses; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D013156:Splenectomy; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology
D000961:Antilymphocyte Serum; D001786:Blood Glucose; D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus