title: Functional epidermal growth factor receptor localizes to the postacrosomal region of human spermatozoa.
abstract: The human epidermal growth factor receptor was detected immunohistochemically in the postacrosomal region of ejaculated human sperm and, when immunopurified and exposed to [gamma-32P]ATP, was found to be autophosphorylated. Localization of an apparently enzymatically active epidermal growth factor receptor to spermatozoa suggests that epidermal growth factor receptor-ligand interactions may play a role in gamete physiology or in fertilization.
authors.affiliation: Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107.
authors.forename: I
authors.initials: I
authors.lastname: Damjanov
authors.forename: D
authors.initials: D
authors.lastname: Solter
authors.forename: B B
authors.initials: BB
authors.lastname: Knowles
mesh_terms: D000911:Antibodies, Monoclonal; D002451:Cell Compartmentation; D066246:ErbB Receptors / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D013094:Spermatozoa / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D000911:Antibodies, Monoclonal; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases