Age-related effects in the inhibition of oxidative metabolism of xenobiotics by mancozeb.
The effect of po administration of 100 or 200 mg mancozeb/kg body weight for 7 consecutive days on microsomal mixed-function oxidase catalyzed xenobiotic metabolism was investigated in the livers of newborn weanling and adults rats. Mancozeb caused a dose-dependent inhibition in the activities of p-nitroanisole O-dealkylase and aniline hydroxylase, while the activities of aminopyrine N-demethylase and benzo(a)pyrene hydroxylase were unaffected in all the age groups. The inhibition of p-nitroanisole O-dealkylase and aniline hydroxylase, was remarkably higher in adult than in newborn and weanling rats. There was a concentration-dependent decrease in cytochrome P-450 and microsomal protein contents. This study indicates selective age-independent inhibition of hepatic monooxygenases following repeated mancozeb dosing.
Siddiqui
A
A
Industrial Toxicology Research Centre, Lucknow, India.
Ali
B
B
Srivastava
S P
SP
D000367:Age Factors; D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D000840:Anisoles / Q000378:metabolism; D001564:Benzo(a)pyrene / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D005659:Fungicides, Industrial / Q000494:pharmacology*; D008297:Male; D008344:Maneb / Q000494:pharmacology*; D008745:Methylation; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010088:Oxidoreductases / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015262:Xenobiotics / Q000378:metabolism*; D015038:Zineb / Q000494:pharmacology*
D000814:Aniline Compounds; D000840:Anisoles; D005659:Fungicides, Industrial; D015262:Xenobiotics; D000632:Aminopyrine; D008344:Maneb; D001564:Benzo(a)pyrene; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; C005306:4-nitroanisole; C013099:mancozeb; C023650:aniline; D015038:Zineb