Mitosis: spindle assembly and chromosome motion.
New studies on mitosis demonstrate the complexity of interactions that contribute to chromosome motion and spindle assembly. Genetic and immunological approaches reveal the requirement for kinesin-related proteins during cell division in diverse cells. Observations of the dynamic behavior of microtubules demonstrate that their disassembly can produce sufficient force to move chromosomes in vitro, that their poleward movement, or flux, contributes to anaphase motion, and that the direction of anaphase motion can be reversed by induction of kinetochore microtubule elongation.
Wadsworth
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Department of Biology, Morrill Science Center, University of Massachusetts, Amherst 01003.
D002455:Cell Division / Q000502:physiology*; D004398:Dyneins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology; D016547:Kinesins / Q000378:metabolism; D008870:Microtubules / Q000502:physiology / Q000648:ultrastructure; D008938:Mitosis / Q000502:physiology*; D009068:Movement; D008941:Spindle Apparatus / Q000378:metabolism*
D004398:Dyneins; D016547:Kinesins