Rates of utilization of intravenous oleylanilide administered chronically to the rat.
The constant injection of [14C]oleylanilide into the vena cava of Wistar rats for 7 days with osmotic minipumps was used to estimate tissue distribution of chronically administered anilides. The largest concentrations of the anilide were found in the brown adipose tissue; all other tissues showed much lower proportions. When anilide distribution was expressed as nmol/g lipid, the high concentration of the compound in the brown adipose tissue contrasted with its very low presence in the white adipose tissue; all other tissues showed intermediate concentrations. Anilide-treated rats consumed more food and lost more weight than did controls; their energy balance showed higher energy inefficiency. The results suggest a possible effect of anilides on the thermogenic pathway of the rat brown adipose tissue. In addition, there was a large individual variability in the proportions of anilide present in all tissues, from as little as 0.3% of the total anilide injected in some animals to 6% in others.
Rodríguez-Martín
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A
Departament de Bioquímica i Fisiologia, Universitat de Barcelona, Spain.
Remesar
X
X
Alemany
M
M
D000273:Adipose Tissue / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000378:metabolism; D000813:Anilides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001835:Body Weight; D002149:Energy Intake; D005260:Female; D009829:Oleic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution; D014684:Venae Cavae
D000813:Anilides; D009829:Oleic Acids; C038731:oleoylanilide