Hypoproteinemia in the hemolytic-uremic syndrome of childhood.
A retrospective review of admission serum protein concentration in 18 children with hemolytic-uremic syndrome (HUS) showed significantly decreased serum total protein, albumin and globulin concentrations upon admission compared with 22 matched controls (P < 0.003). One child with atypical disease without diarrhea had normal serum protein concentrations. A strongly positive correlation (P = 0.006) was found between the age of HUS patients with diarrhea and their lowest total protein concentrations. In 10 children who eventually required hemodialysis, there was a significantly negative correlation (r = -0.8316, P = 0.01) between the admission serum albumin and the patients' highest creatinine levels, suggesting that hypoproteinemia may be a risk factor in the development of renal failure. The pathophysiological and clinical significance of hypoproteinemia in HUS needs further investigation.
Serebruany
V L
VL
Institute of Pediatrics and Children's Surgery, Moscow, Russia.
Christenson
M J
MJ
Pescetti
J
J
McLean
R H
RH
D001798:Blood Proteins / Q000032:analysis; D001806:Blood Urea Nitrogen; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D005916:Globulins / Q000032:analysis; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000150:complications*; D006801:Humans; D007019:Hypoproteinemia / Q000097:blood / Q000209:etiology*; D008297:Male; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis
D001798:Blood Proteins; D005916:Globulins; D012709:Serum Albumin; D003404:Creatinine