Cell wall fractions from Paracoccidioides brasiliensis induce hypergammaglobulinemia.
The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the Fl fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.
de Oliveira
S L
SL
Department of Microbiology and Immunology, UNESP, Botucatu, SP, Brazil.
da Silva
M F
MF
Soares
A M
AM
Silva
C L
CL
D000818:Animals; D000917:Antibody Formation / Q000502:physiology; D002473:Cell Wall / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006942:Hypergammaglobulinemia / Q000276:immunology / Q000382:microbiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010228:Paracoccidioides / Q000276:immunology*; D010229:Paracoccidioidomycosis / Q000276:immunology*; D012756:Sheep / Q000276:immunology