title: [A case of pulmonary tuberculosis complicated with drug toxicosis--value of shosaikoto and hochuekito as anti-allergic agents].
abstract: A clinical course of pulmonary tuberculosis was reported about adverse reaction of anti-tuberculous chemotherapy. A fifty-eight-year-old male patient was complicated with agranulocytosis induced by RFP, hepatic dysfunction and systemic eruption induced by INH, and high fever induced by SM. Adjuvant therapy with Shosaikoto and Hocheukito suppressed INH induced hepato-dermatological toxicosis moderately and suppressed SM induced high fever completely. By these anti-allergic therapy, combined chemotherapy with SM, EB, PAS and PZA became possible during more than six months, and chemotherapeutic effect was marked. This case report suggested possibility and significance of those Kampo agents against serious allergic reaction complicated with the chemotherapy for pulmonary tuberculosis.
authors.affiliation: Division of Lung Diseae, Kyoto Prefectural Yosanoumi Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Onodera
authors.forename: Y
authors.initials: Y
authors.lastname: Kasamatsu
authors.forename: S
authors.initials: S
authors.lastname: Tsujimoto
authors.forename: S
authors.initials: S
authors.lastname: Takemura
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: N
authors.initials: N
authors.lastname: Seto
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
authors.forename: R
authors.initials: R
authors.lastname: Nakahara
authors.forename: N
authors.initials: N
authors.lastname: Ichio
authors.forename: T
authors.initials: T
authors.lastname: Doi
mesh_terms: D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000904:Antibiotics, Antitubercular; D004365:Drugs, Chinese Herbal; C461321:shosaikoto-go-keishika-shakuyakuto