title: Risk factors for groin node metastasis in squamous carcinoma of the vulva: a multivariate analysis of 39 cases.
abstract: This study includes 39 patients with squamous carcinoma of the vulva subjected to radical surgery. Stage, tumor description, cell type, lesion localization, lesion size, depth of invasion, grade, lymphovascular space invasion, number of mitoses, degree of stromal inflammatory reaction, and tumors in surgical margins were analyzed for groin metastasis. Of the factors analyzed, stage (P = 0.018), grade (P = 0.007) and depth of invasion (P = 0.001) were found to be the most important predictors of node metastasis. While a combination of factors permitted to define a low-risk group with 0% node metastasis, it seems hard to identify preoperatively those patients with no risk of nodal metastasis.
authors.affiliation: Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ayhan
authors.forename: R
authors.initials: R
authors.lastname: Tuncer
authors.forename: Z S
authors.initials: ZS
authors.lastname: Tuncer
authors.forename: I
authors.initials: I
authors.lastname: Yücel
authors.forename: H B
authors.initials: HB
authors.lastname: Zeyneloglu
authors.forename: T
authors.initials: T
authors.lastname: Küçükali
authors.forename: O
authors.initials: O
authors.lastname: Develioglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000556:secondary; D005260:Female; D006119:Groin; D006801:Humans; D015994:Incidence; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D012307:Risk Factors; D014846:Vulvar Neoplasms / Q000453:epidemiology* / Q000473:pathology