Compensatory function of central dopaminergic system for suppressing psychic seizures--repeated plasma homovanillic acid measurement in refractory temporal lobe epilepsy.
Repeatedly measured plasma homovanillic acid concentration, as a clinically available index of central dopaminergic activity in a patient with temporal lobe epilepsy during a drug-free period, was significantly correlated with seizure frequency in the week immediately following, but not preceding, blood sampling days. This result suggests a compensatory function of the dopaminergic system in suppressing refractory psychic seizures.
Fukuda
M
M
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan.
Niwa
S I
SI
Kumagai
N
N
Nagakubo
S
S
Shirayama
Y
Y
Hashimoto
O
O
Hata
A
A
Kameyama
T
T
Anzai
N
N
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004833:Epilepsy, Temporal Lobe / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006212:Hallucinations / Q000503:physiopathology; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D011954:Receptors, Dopamine / Q000502:physiology*
D011954:Receptors, Dopamine; D006719:Homovanillic Acid