title: The ascites in the ovarian hyperstimulation syndrome does not originate from the ovary.
abstract: OBJECTIVE
  To evaluate the direct ovarian contribution to ascites formation in the ovarian hyperstimulation syndrome (OHSS) in a rabbit model.
  
  
  METHODS
  Prospective experimental study.
  
  
  METHODS
  Research center of a university teaching hospital.
  
  
  METHODS
  New Zealand White rabbits.
  
  
  METHODS
  Both ovaries of the rabbits in the experimental group were enclosed within a pouch developed from the surrounding peritoneum and mesosalpinx by microsurgery. Animals in the control group did not undergo any surgical intervention. Ovarian hyperstimulation was induced by alternate day equine chorionic gonadotropin and intermittent human chorionic gonadotropin (hCG).
  
  
  METHODS
  Degree of ascites formation and the morphological and endocrinologic signs of ovarian hyperstimulation.
  
  
  RESULTS
  The serial plasma estradiol and progesterone levels, ovarian weights, and ascites response were not statistically different between the two groups.
  
  
  CONCLUSIONS
  Isolation of both ovaries from the peritoneal cavity does not prevent ascites formation in the OHSS. Increased transudation across extraovarian serosal surfaces contributes to ascites formation in OHSS.
authors.affiliation: Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Yarali
authors.forename: B G
authors.initials: BG
authors.lastname: Fleige-Zahradka
authors.forename: B H
authors.initials: BH
authors.lastname: Yuen
authors.forename: P F
authors.initials: PF
authors.lastname: McComb
mesh_terms: D000818:Animals; D001201:Ascites / Q000209:etiology*; D005260:Female; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000503:physiopathology; D010053:Ovary / Q000503:physiopathology*; D011817:Rabbits