[Management of severe pre-eclampsia/eclampsia. Comparison between nifedipine and hydralazine as antihypertensive agents].
The objective was to compare the fetal and maternal effects between parenteral hydralazine and sublingual nifedipine used like antihypertensive drugs in the management of severe preeclampsia. Study design was prospective, comparative, longitudinal, randomized clinical trial. It was carried out at Centro Medico Nacional IMSS Torreon, Coah. Gynecology and Obstetrics Department. The patients were women in the last trimester of pregnancy with severe preeclampsia were randomized to receive parenteral hydralazine or sublingual nifedipine as antihypertensive drugs. The only difference observed in this study was the Apgar of neonates whose mothers received hydralazine, that was significatively lesser than the Apgar of neonates whose mothers received nifedipine. Both medicaments are a good alternative as antihypertensive drugs in severe preeclampsia. Neonates whose mothers received Nifedipine had a higher Apgar.
Walss Rodriguez
R J
RJ
División de Ginecología y Obstetricia, Centro Médico Nacional IMSS Torreón, Coahuila.
Flores Padilla
L M
LM
D000286:Administration, Sublingual; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001034:Apgar Score; D004341:Drug Evaluation; D004461:Eclampsia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage*; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D008137:Longitudinal Studies; D009543:Nifedipine / Q000008:administration & dosage*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies
D000959:Antihypertensive Agents; D006830:Hydralazine; D009543:Nifedipine