Selective delivery of etoposide to intraperitoneal tissues using a new dosage format: etoposide microcrystals suspended in oil.
Rats received an intraperitoneal bolus injection of etoposide at 5 mg/kg of body weight in the form of an etoposide microcrystal suspension in oil (ETOP-OIL) or an aqueous etoposide solution. The tissue distribution was subsequently analyzed using high performance liquid chromatography. ETOP-OIL delivered significantly greater amounts of etoposide and for a longer duration to the intraperitoneal tissues such as the omentum and the spleen, whereas it delivered significantly less etoposide to the rest of the body such as the lung, the heart and the bone marrow, than the aqueous etoposide solution.
Hagiwara
A
A
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Lee
M
M
Sakakura
C
C
Shoubayashi
S
S
Tashima
S
S
Yamamoto
A
A
Muranishi
S
S
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D005047:Etoposide / Q000097:blood / Q000493:pharmacokinetics*; D006321:Heart / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D009821:Oils; D009852:Omentum; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D013535:Suspensions; D001743:Urinary Bladder / Q000187:drug effects
D009821:Oils; D012996:Solutions; D013535:Suspensions; D005047:Etoposide