title: Mode of ascertainment is critical in assessing safety of percutaneous umbilical blood sampling.
abstract: Percutaneous umbilical blood sampling (PUBS) is increasingly utilized for cytogenetic assessment of the fetus. In the present study, outcome of 109 PUBS-derived fetal blood samples were analyzed according to mode of ascertainment: ultrasound-detected anatomic anomalies or intrauterine growth retardation (IUGR). Abnormal chromosome complements were found in 6 of 47 (12.8%) fetuses with anomalies but in only 1 of 62 (1.6%) fetuses with IUGR alone. Perinatal loss in fetuses with anatomic anomalies was 64.4%, compared with only 1.6% in fetuses with IUGR alone. Mode of patient ascertainment is an important factor that must be considered in determining procedure-related risks for PUBS.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103-2896.
authors.forename: L P
authors.initials: LP
authors.lastname: Shulman
authors.forename: M L
authors.initials: ML
authors.lastname: Moretti
authors.forename: A T
authors.initials: AT
authors.lastname: Tharapel
authors.forename: D C
authors.initials: DC
authors.lastname: Shaver
authors.forename: B M
authors.initials: BM
authors.lastname: Mercer
authors.forename: B M
authors.initials: BM
authors.lastname: Sibai
authors.forename: C M
authors.initials: CM
authors.lastname: Meyers
authors.forename: O P
authors.initials: OP
authors.lastname: Phillips
authors.forename: J V
authors.initials: JV
authors.lastname: Dacus
authors.forename: J R
authors.initials: JR
authors.lastname: Barton
mesh_terms: D001800:Blood Specimen Collection / Q000379:methods; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging; D005260:Female; D005312:Fetal Blood; D005315:Fetal Diseases / Q000235:genetics*; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000009:adverse effects / Q000379:methods*; D012307:Risk Factors; D012449:Safety; D016216:Ultrasonography, Prenatal