Exact repeated confidence intervals for Bernoulli parameters in a group sequential clinical trial.
This paper presents methods for constructing exact repeated confidence intervals (RCIs) for the success probability, p, of a single Bernoulli treatment and for the difference of success probabilities, delta = p1-p2, of two independent Bernoulli treatments in the context of a group sequential clinical trial. These RCIs calculated at each interim analysis are useful for evaluating the data in light of all the information available rather than relying on rigid stopping criteria used by repeated significance tests. Extensions to construction of RCIs for the relative risk p = p1/p2 and odds ratio psi = p1(1-p2)/p2(1-p1) are indicated.
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Roosevelt University, Chicago, Illinois.
Tamhane
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D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016010:Binomial Distribution; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D016001:Confidence Intervals; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D016017:Odds Ratio; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D012306:Risk; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D011241:Prednisone