The effect of hyperbaric oxygenation on bone in spontaneously hypertensive rats.
We investigated whether hyperbaric oxygenation treatment can enhance osteogenesis in spontaneously hypertensive rats (SHRs). 8-week-old SHRs were exposed to hyperbaric oxygen for 6 weeks and were killed at 17 weeks of age. Wistar-Kyoto normal rats and untreated SHRs of the same age were used as controls. Radiographic measurements of cortical thickness and length of femora showed that these parameters increased in oxygen-treated SHRs; they became almost normal. Ash weight and ash, Ca and P content of L5 vertebras showed similar results. We conclude that high partial pressure oxygen has an effect on osteogenesis in SHRs.
Matsuda
T
T
Department of Orthopedics, Nagoya University School of Medicine, Japan.
Hasegawa
Y
Y
Kataoka
Y
Y
Iwata
H
H
Miura
T
T
Takahashi
H
H
D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000737:chemistry*; D002118:Calcium / Q000032:analysis; D005269:Femur / Q000737:chemistry / Q000254:growth & development; D006931:Hyperbaric Oxygenation; D008159:Lumbar Vertebrae / Q000737:chemistry / Q000254:growth & development; D008297:Male; D009929:Organ Size; D010710:Phosphates / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D010710:Phosphates; D002118:Calcium