Electron microscopic and immunohistochemical findings in a case of olfactory neuroblastoma.
A case of olfactory neuroblastoma is reported. Light microscopic examination showed various arrangements of poorly differentiated tumour cells forming either uniform sheets or convoluted cords of multiple cell layers orientated toward a richly vascular stroma. Electron microscopic examination showed the presence of abundant cytoplasmic filaments and processes, and dense core endocrine vesicles ranging from 100-160 nm in diameter in both the perinuclear region and tumour cell processes. Immunohistochemical staining was positive in most of the tumour cells for neuron specific enolase, and in a few cells for S-100 protein, vimentin, and serotonin, but staining for desmin and keratin produced no reaction.
Du
Z M
ZM
Department of Pathology, Fourth Military Medical University, Xi'an Shaanxi, People's Republic of China.
Li
Y S
YS
Wang
B F
BF
D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009300:Nasal Septum; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000737:chemistry / Q000648:ultrastructure*; D009669:Nose Neoplasms / Q000737:chemistry / Q000648:ultrastructure*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase