title: Isolation and biological effects of 7-O-methyleriodictyol, a flavanone isolated from Artemisia monosperma, on rat isolated smooth muscles.
abstract: The isolation for the first time from the genus Artemisia (Compositae) of the known flavanone, 7-O-methyleriodictyol (7-methoxy-5,3',4'-trihydroxy-flavanone), its identification, and its biological effects on rat isolated smooth muscles are described. 7-O-Methyleriodictyol (10(-7) M to 3 x 10(-4) M) caused concentration-dependent inhibition of the amplitude of the phasic contractions and reduced the tone of the ileum, the uterus, and the urinary bladder. It also caused relaxation of the phenylephrine-precontracted pulmonary artery and the acetylcholine-precontracted trachea. The flavanone also shifted to the right the acetylcholine concentration-effect curve on the ileum and the oxytocin concentration-effect curve on the uterus. The maximum contractions induced by acetylcholine or oxytocin were also inhibited by 7-O-methyleriodictyol. These antispasmodic effects are partly consistent with the use of A. monosperma in folk medicine for certain gastrointestinal disorders.
authors.affiliation: Department of Biological Sciences, University of Jordan, Amman.
authors.forename: L
authors.initials: L
authors.lastname: Abu-Niaaj
authors.forename: M
authors.initials: M
authors.lastname: Abu-Zarga
authors.forename: S
authors.initials: S
authors.lastname: Sabri
authors.forename: S
authors.initials: S
authors.lastname: Abdalla
mesh_terms: D000818:Animals; D005260:Female; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D044950:Flavanones; D005419:Flavonoids; D010276:Parasympatholytics; D010936:Plant Extracts; C079930:7-O-methyleriodictyol