title: Hereditary necrotising myelopathy in Kooiker dogs.
abstract: A retrospective clinicopathological study of a neurological disorder in 22 Kooiker dogs (Dutch decoy dog) was made. The disease was found to occur equally in both sexes and clinical signs began at three to 12 months old. Physical examination revealed a progressive paresis of the hindlimbs. Post mortem examination showed symmetrical areas of malacia in the ventral, lateral and dorsal white matter of the spinal cord. In one dog dorsal white matter was spared. Cervical segments C4 to C8 were involved in all subjects. Rostral and caudal to these areas, Wallerian degeneration was prominent. The disease has much in common with similar myelopathies in the Afghan hound and the rottweiler. Indications of heritability were the similarity in clinical and pathological findings, the age of onset of the disease, and the significantly higher inbreeding coefficient in the patients than in the breed population (P = 0.001). All patients were descended from one pair. Segregation analysis suggested inheritance involving a simple autosomal recessive trait.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Mandigers
authors.forename: J J
authors.initials: JJ
authors.lastname: Van Nes
authors.forename: B W
authors.initials: BW
authors.lastname: Knol
authors.forename: G J
authors.initials: GJ
authors.lastname: Ubbink
authors.forename: E
authors.initials: E
authors.lastname: Gruys
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D009135:Muscular Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D009336:Necrosis; D010375:Pedigree; D012189:Retrospective Studies