Chromogranin A, a soluble synaptic vesicle protein, is found in cortical neurons other than previously defined peptidergic neurons in the human neocortex.
Neuropeptides in the cerebral cortex have previously been identified in non-pyramidal neurons only. By comparing the location of chromogranin A (CgA), a soluble protein of large dense-core synaptic vesicles, with that of SMI-32, neuropeptide Y (NPY), parvalbumin (PV) and calbindin (CaBP) using double label immunohistochemistry, we demonstrate that CgA is present in pyramidal neurons as well as in several subtypes of non-pyramidal neurons.
Adams
L A
LA
Department of Pathology, University of Western Ontario, London, Canada.
Ang
L C
LC
Munoz
D G
DG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D003712:Dendrites / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism*; D010455:Peptides / Q000502:physiology*; D011712:Pyramidal Tracts / Q000166:cytology / Q000378:metabolism; D013572:Synaptic Vesicles / Q000276:immunology / Q000378:metabolism
D000911:Antibodies, Monoclonal; C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D010455:Peptides