title: Intermittent sinusoidal heart rate pattern in vagotomized fetal lambs.
abstract: OBJECTIVE
  Our aims were to investigate the relationship between the dose of arginine vasopressin and the pattern and duration of arginine vasopressin-induced sinusoidal fetal heart rate and to elucidate the correlation between intermittent sinusoidal heart rate and fetal sleep cycle.
  
  
  METHODS
  Sinusoidal heart rate pattern was induced by intravenous arginine vasopressin infusion at doses from 2 to 78 mlU/min into 11 chronically instrumented fetal lambs with bilateral cervical vagotomy. Appearance and frequency of sinusoidal heart rate, intermittent sinusoidal heart rate, and persistent sinusoidal heart rate were observed along with fetal tracheal pressure and electrooculogram.
  
  
  RESULTS
  Intermittent sinusoidal heart rate response to low, medium, and high doses of arginine vasopressin appeared in 73.3%, 50.0%, and 33.3% of experiments, respectively. Intermittent sinusoidal heart rate appeared more frequently than persistent sinusoidal heart rate with lower doses (p < 0.02). When intermittent sinusoidal heart rate was induced, the incidence of sinusoidal patterns significantly increased during non-rapid-eye-movement sleep in comparison with rapid-eye-movement sleep (p < 0.01).
  
  
  CONCLUSIONS
  Appearance of sinusoidal heart rate seems to be related to the dose of arginine vasopressin infused. Appearance of sinusoidal heart rate is also influenced by fetal sleep cycle; sinusoidal heart rate is more likely to appear during non-rapid-eye-movement sleep than during rapid-eye-movement sleep. These results support the hypothesis that persistent sinusoidal heart rate correlates with severity of stress.
authors.affiliation: Department of Obstetrics and Gynecology, University of California, Irvine, Orange 92613-1491.
authors.forename: Y
authors.initials: Y
authors.lastname: Ninomiya
authors.forename: P C
authors.initials: PC
authors.lastname: McMahan
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
authors.forename: A
authors.initials: A
authors.lastname: Wakatsuki
authors.forename: N
authors.initials: N
authors.lastname: Masaoka
authors.forename: M
authors.initials: M
authors.lastname: Porto
authors.forename: J G
authors.initials: JG
authors.lastname: Tyner
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000502:physiology*; D006340:Heart Rate, Fetal / Q000187:drug effects; D011247:Pregnancy; D012756:Sheep; D012894:Sleep Stages; D014628:Vagotomy
chemical_list: D001127:Arginine Vasopressin