title: Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94.
abstract: The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2-->q24.3), and 15 (q25-->q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designated TRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 and TRAP2) appear to be independently derived, processed pseudogenes.
authors.affiliation: Department of Pharmacology, Mount Sinai School of Medicine, CUNY, New York 10029.
authors.forename: R G
authors.initials: RG
authors.lastname: Maki
authors.forename: R L
authors.initials: RL
authors.lastname: Eddy
authors.forename: M
authors.initials: M
authors.lastname: Byers
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: P K
authors.initials: PK
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D004247:DNA; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011544:Pseudogenes
chemical_list: D000951:Antigens, Neoplasm; D006360:Heat-Shock Proteins; D008562:Membrane Glycoproteins; C052646:sarcoma glycoprotein gp96 rejection antigens; D004247:DNA