Multiple levels of peripheral tolerance.
The establishment and maintenance of self tolerance is based on multiple events in the thymus and periphery, resulting in either deletion of self-reactive T cells or induction of nonresponsiveness. Here, Bernd Arnold and colleagues propose that, depending on the tolerogenic signals, peripheral T cells can reach different levels of tolerance with regard to their capacity for reactivation. In addition, it appears that tolerant T cells are still susceptible to further tolerogenic signals, driving them into a deeper state of tolerance. Thus, induction of T-cell tolerance can be viewed as a multistep mechanism.
Arnold
B
B
Division of Somatic Genetics, Tumor Immunology Program, German Cancer Research Center, Heidelberg.
Schönrich
G
G
Hämmerling
G J
GJ
D000818:Animals; D015395:Histocompatibility Antigens Class I; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
D015395:Histocompatibility Antigens Class I