title: Decomposition of hydrogen peroxide by metmyoglobin: a cyclic formation of the ferryl intermediate.
abstract: 1. Metmyoglobin reacted with H2O2 to form ferryl-myoglobin, which reverted back spontaneously to the met-form. 2. Through this cyclic reaction of myoglobin between metMb(III) and ferryl-Mb(IV), we proposed that H2O2, one of the potent oxidants in vivo, can be decomposed continuously in cardiac and skeletal muscle tissues in the absence of catalase and peroxidase.
authors.affiliation: Department of Biological Science, College of General Education, Tohoku University, Sendai, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Tajima
authors.forename: K
authors.initials: K
authors.lastname: Shikama
mesh_terms: D000818:Animals; D002417:Cattle; D006861:Hydrogen Peroxide / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008786:Metmyoglobin / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D008968:Molecular Conformation; D009206:Myocardium / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: C028048:ferrylmyoglobin; D008786:Metmyoglobin; D006861:Hydrogen Peroxide