title: Activity-dependent regulation of conductances in model neurons.
abstract: Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.
authors.affiliation: Department of Biology, Brandeis University, Waltham, MA 02254.
authors.forename: G
authors.initials: G
authors.lastname: LeMasson
authors.forename: E
authors.initials: E
authors.lastname: Marder
authors.forename: L F
authors.initials: LF
authors.lastname: Abbott
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D004553:Electric Conductivity; D004558:Electric Stimulation; D005246:Feedback; D008954:Models, Biological; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology; D015290:Second Messenger Systems; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium; D011188:Potassium; D002118:Calcium