RETRACTED: Influence of acute preoperative plasmapheresis on platelet function in cardiac surgery.
Withdrawal of autologous plasma offers the possibility of improving patients' hemostasis and of reducing homologous blood consumption in cardiac surgery. The influence of acute, preoperatively performed plasmapheresis (APP) on platelet function was investigated in elective aortocoronary bypass patients subjected to APP producing either platelet-poor plasma (PPP; group 1; n = 12) or platelet-rich plasma (PRP; group 2; n = 12). APP-treated patients were randomly compared to patients without APP (control group; n = 12). Platelet aggregation induced by ADP (concentration 0.25, 0.5, 1.0, and 2.0 mumol/L), collagen (4 microL/mL), and epinephrine (25 mumol/L) was determined by the turbidometric method before and after APP, as well as before and after cardiopulmonary bypass (CPB) until the morning of the 1st postoperative day. APP had no negative effects on the patients' aggregation parameters (maximum aggregation and maximum gradient of aggregation). The platelet counts in the withdrawn plasma were 25 +/- 10 x 10(9)/L (PPP-group) and 250 +/- 30 x 10(9)/L (PRP-group). Platelet counts were highest in the PRP-group at the end of the operation (after retransfusion of autologous plasma). After CPB, maximum aggregation and maximum gradient of aggregation were reduced in all groups (ranging from -6% to -25% from baseline values). Retransfusion of autologous plasma improved platelet aggregability significantly only in the PRP-group. By the first postoperative day, maximum aggregation and maximum gradient of aggregation recovered in all groups (including the control group) or even exceeded baseline values (ranging from +8% to +42% from baseline values.(ABSTRACT TRUNCATED AT 250 WORDS)
Boldt
Joachim
J
From the Department of Anesthesiology and Intensive Care Medicine Germany; Department of Cardiovascular Surgery, Justus-Liebig-University Giessen, Giessen, Germany.
Zickmann
Bernfried
B
From the Department of Anesthesiology and Intensive Care Medicine Germany; Department of Cardiovascular Surgery, Justus-Liebig-University Giessen, Giessen, Germany.
Ballesteros
Mauricio
M
From the Department of Anesthesiology and Intensive Care Medicine Germany; Department of Cardiovascular Surgery, Justus-Liebig-University Giessen, Giessen, Germany.
Oehmke
Stephan
S
From the Department of Anesthesiology and Intensive Care Medicine Germany; Department of Cardiovascular Surgery, Justus-Liebig-University Giessen, Giessen, Germany.
Stertmann
Fred
F
From the Department of Anesthesiology and Intensive Care Medicine Germany; Department of Cardiovascular Surgery, Justus-Liebig-University Giessen, Giessen, Germany.
Hempelmann
Gunter
G
From the Department of Anesthesiology and Intensive Care Medicine Germany; Department of Cardiovascular Surgery, Justus-Liebig-University Giessen, Giessen, Germany.
D001780:Blood Coagulation Tests; D016913:Blood Component Transfusion; D016063:Blood Loss, Surgical; D001792:Blood Platelets / Q000502:physiology*; D001804:Blood Transfusion, Autologous; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D010974:Platelet Aggregation; D010976:Platelet Count; D010983:Plateletpheresis; D011300:Preoperative Care