Effects of a 60 Hz magnetic field on central cholinergic systems of the rat.
We studied the effects of an acute (45 min) exposure to a 60 Hz magnetic field on sodium-dependent, high-affinity choline uptake in the brain of the rat. Decreases in uptake were observed in the frontal cortex and hippocampus after the animals were exposed to a magnetic field at flux densities > or = 0.75 mT. These effects of the magnetic field were blocked by pretreating the animals with the narcotic antagonist naltrexone, but not by the peripheral opioid antagonist, naloxone methiodide. These data indicate that the magnetic-field-induced decreases in high-affinity choline uptake in the rat brain were mediated by endogenous opioids in the central nervous systems.
Lai
H
H
Department of Pharmacology, University of Washington, Seattle 98195.
Carino
M A
MA
Horita
A
A
Guy
A W
AW
D000818:Animals; D001921:Brain / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D004574:Electromagnetic Fields / Q000009:adverse effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009270:Naloxone; D009271:Naltrexone; D002794:Choline