Six generations of a family with multiple limb deficiencies.
Ectrodactyly, with or without other limb reduction defects, is a rare congenital anomaly. The pattern of inheritance is usually autosomal dominant, but with variable morphology. We report six generations of a family with this anomaly, with a progressive increase in severity and extent of involvement. Implications of genetic counseling are discussed.
Helal
A
A
Shriners Hospitals for Crippled Children, Tampa Unit, Florida 33612-9499.
Perry
T
T
Ogden
J A
JA
Greene
T L
TL
D000015:Abnormalities, Multiple / Q000235:genetics*; D001132:Arm / Q000002:abnormalities*; D005260:Female; D005385:Fingers / Q000002:abnormalities; D005532:Foot Deformities, Congenital / Q000235:genetics*; D005817:Genetic Counseling; D006228:Hand Deformities, Congenital / Q000235:genetics*; D006801:Humans; D007223:Infant; D007866:Leg / Q000002:abnormalities*; D010375:Pedigree; D014034:Toes / Q000002:abnormalities