Regional metabolism of 5-hydroxytryptamine in brain under acute and chronic heat stress.
The metabolic alteration of 5-HT in four different regions of rat brain and plasma was studied under acute and chronic heat stress. A generalised elevation of 5-HT in all the brain regions along with high plasma level was observed in animals subjected to 4 hour heat stress at 38 degrees C. Such elevation of brain 5-HT may be due to entry of plasma 5-HT into the brain owing to breakdown of blood-brain barrier (BBB). In heat adapted rats, where BBB remained unaffected, no increase in brain 5-HT was observed, rather a significantly low level was maintained both in plasma and brain tissue.
Dey
S
S
Department of Physiology, Banaras Hindu University, Varanasi.
Dey
P K
PK
Sharma
H S
HS
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D000208:Acute Disease; D000222:Adaptation, Physiological / Q000502:physiology; D000409:Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000097:blood / Q000378:metabolism*; D013312:Stress, Physiological / Q000097:blood / Q000378:metabolism*
D012701:Serotonin; D000409:Alanine; D015115:5,6-Dihydroxytryptamine