title: A new antibacterial sesquiterpene from Premna oligotricha.
abstract: A novel sesquiterpene, 7 alpha-hydroxy-6, 11-cyclofarnes-3(15)-en-2-one [1], has been isolated from the aerial parts of Premna oligotricha (Verbenaceae) using an antimicrobial bioassay-guided isolation procedure. The sesquiterpene was identified on the basis of spectroscopic data and showed weak activity against Gram-positive bacteria Bacillus pumilus, Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis.
authors.affiliation: Department of Pharmaceutical Science, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: S
authors.initials: S
authors.lastname: Habtemariam
authors.forename: A I
authors.initials: AI
authors.lastname: Gray
authors.forename: P G
authors.initials: PG
authors.lastname: Waterman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010944:Plants / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; C080230:7-hydroxy-6,11-cyclofarnes-3(15)-en-2-one