[Effect of intra-venous hyperalimentation on hepatic energy metabolism after hepatic resection in the cirrhotic rat].
We evaluated experimentally the effect of administration of glucose on hepatic energy metabolism, mitochondrial functions and lipid metabolism after hepatic resection. The 75% hepatic resection was performed on thioacetamide induced cirrhotic rat. Glucose solution with 30 Cal/kg/day (group I) or 200 Cal/kg/day (group II) was administrated intravenously for 48 hours after hepatic resection. Blood levels of ketone bodies and glucagon, tissue activities of ATP synthesis and tissue content of adenine nucleotides were measured in both groups. Hepatic energy charge was significantly decreased in group II, comparing with group I. When fatty acid was used as a substrate for respiratory system, the activity of ATP synthesis on mitochondria after hepatic resection rose, while in case pyruvate was used as a substrate the value was declined. On the levels of serum free fatty acids and ketone bodies, there were no remarkable changes in group I, while in group II, obvious declines were investigated. It is suggested that the overload of glucose in the early stage after hepatic resection is unfavorable to hepatic energy metabolism because of decline of serum free fatty acid by hyperinsulinemia and suppression of fatty acid oxidation by decline of blood glucagon.
Sakai
K
K
First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Ouchi
K
K
Sato
R
R
Oguma
S
S
Matsuno
S
S
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004734:Energy Metabolism; D005934:Glucagon / Q000097:blood; D005947:Glucose / Q000008:administration & dosage*; D006498:Hepatectomy; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism* / Q000601:surgery / Q000628:therapy; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D011184:Postoperative Period; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D005947:Glucose