title: Role of leuprolide acetate depot in hysteroscopic surgery: a controlled study.
abstract: OBJECTIVE
  To evaluate leuprolide acetate (LA) depot (Enantone Depot, Takeda, Italy) when administered preoperatively in hysteroscopic surgery.
  
  
  METHODS
  Prospective, comparative study.
  
  
  METHODS
  University Clinic of Obstetrics and Gynecology.
  
  
  METHODS
  One hundred ninety-three patients (114 pretreated with LA depot and 79 controls) who underwent hysteroscopic surgery for uterine septa (group A), submucous fibroids (group B), and abnormal uterine bleeding (group C).
  
  
  RESULTS
  In groups B and C there was a significant reduction in the operating time, bleeding during the operation, and the amount of distention medium required after LA depot administration, but no significant differences in surgical feasibility or efficacy were found in group A patients after treatment.
  
  
  CONCLUSIONS
  Preoperative treatment with LA depot is effective in making hysteroscopic surgery easier.
authors.affiliation: Cattedra di Fisiopatologia della Riproduzione Umana, University of Palermo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Perino
authors.forename: N
authors.initials: N
authors.lastname: Chianchiano
authors.forename: M
authors.initials: M
authors.lastname: Petronio
authors.forename: E
authors.initials: E
authors.lastname: Cittadini
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004717:Endometrium / Q000601:surgery; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009215:Myometrium / Q000601:surgery; D011446:Prospective Studies; D014592:Uterine Hemorrhage / Q000601:surgery; D014594:Uterine Neoplasms / Q000601:surgery; D014599:Uterus / Q000601:surgery*
chemical_list: D003692:Delayed-Action Preparations; D016729:Leuprolide