title: Long-term effects on the thyroid of irradiation for skin angiomas in childhood.
abstract: Thyroid morphological and functional tests were carried out on 396 patients who were recalled because their thyroid gland had been exposed during hemangioma irradiation in childhood 11-43 years before (median, 22 years). The irradiations have been classified into two categories based on their duration: short duration, from a few seconds to a few minutes (90S and X rays), and long duration, from 30 min to several hours (336Ra, 192Ir, and 32P). The risk of a thyroid nodule increased significantly with the total dose received by the thyroid; it was linked to the dose delivered in the short duration (excess relative risk per Gy = 10), but not to that delivered in the long duration. The risk of a simple diffuse goiter, which also increased with the dose received by the thyroid, did not depend on the duration of the irradiation. In conclusion, this study emphasizes the role of the dose rate in the risk of thyroid nodule, the detection of which does not appear to be improved by plasma thyroid marker determination.
authors.affiliation: U351 INSERM, Institut Gustave Roussy, Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: de Vathaire
authors.forename: P
authors.initials: P
authors.lastname: Fragu
authors.forename: P
authors.initials: P
authors.lastname: François
authors.forename: S
authors.initials: S
authors.lastname: Benhamou
authors.forename: P
authors.initials: P
authors.lastname: Ward
authors.forename: E
authors.initials: E
authors.lastname: Benhamou
authors.forename: M F
authors.initials: MF
authors.lastname: Avril
authors.forename: E
authors.initials: E
authors.lastname: Grimaud
authors.forename: H
authors.initials: H
authors.lastname: Sancho-Garnier
authors.forename: C
authors.initials: C
authors.lastname: Parmentier
mesh_terms: D002648:Child; D005602:France / Q000453:epidemiology; D006391:Hemangioma / Q000453:epidemiology / Q000532:radiotherapy*; D006801:Humans; D012189:Retrospective Studies; D012306:Risk; D012878:Skin Neoplasms / Q000453:epidemiology / Q000532:radiotherapy*; D013961:Thyroid Gland / Q000528:radiation effects*; D016606:Thyroid Nodule / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors