title: Stewart's quantitative acid-base chemistry: applications in biology and medicine.
abstract: We review P.A. Stewart's quantitative approach to acid-base chemistry, starting with its historical context. We outline its implications for cellular and membrane processes in acid-base physiology; discuss its contributions to the understanding and analysis of acid-base phenomena; show how it can be applied in clinical problems; and propose a classification of clinical acid-base disturbances based on this general approach.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: V
authors.initials: V
authors.lastname: Fencl
authors.forename: D E
authors.initials: DE
authors.lastname: Leith
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000137:Acid-Base Imbalance / Q000145:classification / Q000503:physiopathology; D001692:Biological Transport / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D006801:Humans