Retroperitoneal reticulum cell sarcoma: a cause of paraneoplastic pemphigus.
A 67-year-old man had mucosal ulcerations and bullous and lichenoid skin lesions resembling those of several other patients with underlying neoplasms. Computed tomography revealed an occult retroperitoneal sarcoma. Autoantibodies pathogenic to epithelia induce this syndrome, which has been termed "paraneoplastic pemphigus." Imaging for an occult neoplasm should be considered in patients with similar mucosal and skin lesions.
Berg
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Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Md 21205.
Fishman
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D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001706:Biopsy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D003598:Cytoskeletal Proteins / Q000276:immunology; D051180:Desmoplakins; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010392:Pemphigus / Q000188:drug therapy / Q000209:etiology*; D010956:Plasmapheresis; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D011878:Radiotherapy; D012186:Retroperitoneal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D001323:Autoantibodies; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D016756:Immunoglobulins, Intravenous; D003520:Cyclophosphamide; D011241:Prednisone