title: Rebound thymic hyperplasia following high dose chemotherapy and allogeneic BMT.
abstract: We describe a child with acute lymphoblastic leukemia who showed mediastinal widening 8 months after allogeneic BMT. Total thymectomy was carried out by the transcervical approach. Histologic examination showed only thymic hyperplasia. The immunohistologic investigation revealed a normal distribution of thymic cell elements, without evidence of clonal proliferation of lymphocytic subpopulations. This case supports the hypothesis that thymic hyperplasia following chemotherapy may be merely a rebound phenomenon. The patient had an uneventful postoperative recovery and remains in remission more than 1 year after BMT.
authors.affiliation: Department of Pediatrics, University of Turin, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Miniero
authors.forename: A
authors.initials: A
authors.lastname: Busca
authors.forename: E
authors.initials: E
authors.lastname: Leonardo
authors.forename: C
authors.initials: C
authors.lastname: Mossetti
authors.forename: D
authors.initials: D
authors.lastname: Machado
authors.forename: E
authors.initials: E
authors.lastname: Vassallo
authors.forename: E
authors.initials: E
authors.lastname: Madon
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000601:surgery; D013934:Thymectomy; D013952:Thymus Hyperplasia / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000970:Antineoplastic Agents