The altricial pigeon is born blind with a transient glycogen cataract.
The lens nucleus of altricial birds contains a large amount of glycogen. It is not known why glycogen in such concentration does not cause a trace of lens opalescence. Here we report that the altricial pigeon is born with a dense nuclear opacity; this opacity has practically disappeared by 4 weeks of age. Thin-section electron microscopy revealed that the opacity was specifically associated with an enormous number of large glycogen aggregates in nuclear fiber cells. These aggregates of various sizes (up to approximately 5 microns) were composed of smaller individual 35-nm beta glycogen particles. In contrast, glycogen aggregates were not seen in nuclear fiber cells of all transparent older lenses. The glycogen aggregates have gradually dissociated into a homogeneous distribution of individual beta particles in the entire cytoplasm of nuclear fibers which accompanies the development of lens transparency. This study suggests that an extensive accumulation of glycogen aggregates in the lens nucleus is the cause of light scattering and opacification. The transparency of the altricial pigeon lens during normal development is therefore regulated by two different forms of glycogen. Precocial birds such as chick have no lens glycogen, therefore never develop a glycogen cataract and have excellent visual acuity upon hatching.
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Department of Anatomy, Morehouse School of Medicine, Atlanta, GA 30310.
Kuck
J F
JF
Shaw
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AP
Yu
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NT
D000371:Agglutination; D000818:Animals; D001766:Blindness / Q000151:congenital*; D002386:Cataract / Q000151:congenital*; D010856:Columbidae; D006003:Glycogen / Q000032:analysis; D007907:Lens Nucleus, Crystalline / Q000737:chemistry / Q000648:ultrastructure; D008854:Microscopy, Electron; D013997:Time Factors
D006003:Glycogen