title: Systemic amyloidosis AL with temporal artery involvement revealing lymphoplasmacytic malignancy in a man presenting as polymyalgia rheumatica.
abstract: A 68 year old man presented with a clinical and biological picture that suggested polymyalgia rheumatica. Temporal artery biopsy disclosed no inflammatory change but massive light chain amyloid deposits in the media. Further exploration showed a malignant lymphoplasmacytic haemopathy with a triclonal gammopathy and a muscular, rectal, and probable cardiac amyloidosis. Cryoglobulinaemia and high concentrations of soluble interleukin 2 receptor (sIL-2R) were also found. This is the fifth case with confirmed involvement of the temporal artery. The especially high sIL-2R concentration was thought to reflect the tumour mass rather than lymphocyte activation.
authors.affiliation: Department of Rheumatology, Timone Hospital, Marseilles, France.
authors.forename: P
authors.initials: P
authors.lastname: Lafforgue
authors.forename: E
authors.initials: E
authors.lastname: Senbel
authors.forename: D
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: J
authors.initials: J
authors.lastname: Boucraut
authors.forename: N
authors.initials: N
authors.lastname: Horschowsky
authors.forename: J F
authors.initials: JF
authors.lastname: Pellissier
authors.forename: P C
authors.initials: PC
authors.lastname: Acquaviva
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000473:pathology; D011111:Polymyalgia Rheumatica / Q000175:diagnosis*; D013699:Temporal Arteries