title: Six generations of a family with multiple limb deficiencies.
abstract: Ectrodactyly, with or without other limb reduction defects, is a rare congenital anomaly. The pattern of inheritance is usually autosomal dominant, but with variable morphology. We report six generations of a family with this anomaly, with a progressive increase in severity and extent of involvement. Implications of genetic counseling are discussed.
authors.affiliation: Shriners Hospitals for Crippled Children, Tampa Unit, Florida 33612-9499.
authors.forename: A
authors.initials: A
authors.lastname: Helal
authors.forename: T
authors.initials: T
authors.lastname: Perry
authors.forename: J A
authors.initials: JA
authors.lastname: Ogden
authors.forename: T L
authors.initials: TL
authors.lastname: Greene
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D001132:Arm / Q000002:abnormalities*; D005260:Female; D005385:Fingers / Q000002:abnormalities; D005532:Foot Deformities, Congenital / Q000235:genetics*; D005817:Genetic Counseling; D006228:Hand Deformities, Congenital / Q000235:genetics*; D006801:Humans; D007223:Infant; D007866:Leg / Q000002:abnormalities*; D010375:Pedigree; D014034:Toes / Q000002:abnormalities