Differences in naphthalene cataract formation between albino and pigmented rat eyes.
The progression of naphthalene cataracts induced in Brown-Norway rats and Sprague-Dawley rats was compared. The quality of lens changes was basically the same in both strains. However, the cataract progression in Brown-Norway rats showed regularity and was fast as compared with the progression in Sprague-Dawley rats. The cataract development could be divided into three stages. Stage 1: formation of water clefts below the anterior lens capsule (shallow cortex) was observed as the initial change; stage 2: these water clefts extended into the deeper cortical layers, and a semicircular opaque band at the deeper cortical region becomes visible; stage 3: a retroillumination image revealed a ring shadow formation - slit image observation showed wedge-shaped cortical and deeper cortical zonular opacification as the final stage. The expression of these three stages in Sprague-Dawley rats is less uniform and timely delayed as compared with Brown-Norway rats.
Murano
H
H
Department of Ophthalmology, Kanazawa Medical University, Uchinada, Japan.
Kojima
M
M
Sasaki
K
K
D016115:Albinism, Oculocutaneous / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D002386:Cataract / Q000139:chemically induced / Q000473:pathology*; D004195:Disease Models, Animal; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D009281:Naphthalenes; D051381:Rats; D011914:Rats, Inbred BN; D017207:Rats, Sprague-Dawley; D013045:Species Specificity
D009281:Naphthalenes; C031721:naphthalene