Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.
Phosphorylase kinase (PHK) is a regulatory enzyme of the glycogenolytic pathway composed of a complex of four subunits. We recently mapped the muscle alpha-subunit gene (Phka) to the mouse X chromosome in a region syntenic with the proximal long arm of the human X chromosome and containing the human homologue of this gene, PHKA. We now report the mapping of the liver alpha-subunit gene to the telomeric end of the mouse X chromosome. This mapping position would suggest a location for the human liver alpha-subunit gene on the proximal short arm of the X chromosome, a region recently implicated in X-linked liver glycogenosis (XLG).
Geng
Y
Y
MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, United Kingdom.
Derry
J M
JM
Hendrickx
J
J
Coucke
P
P
Willems
P R
PR
Barnard
P J
PJ
D000818:Animals; D002874:Chromosome Mapping; D008099:Liver / Q000201:enzymology*; D051379:Mice; D010764:Phosphorylase Kinase / Q000235:genetics*; D014960:X Chromosome
D010764:Phosphorylase Kinase