Clozapine.
Clozapine is an atypical agent for intractable schizophrenia which was introduced into the UK at the beginning of 1990. Its lack of extrapyramidal side effects and its action on negative symptoms single it out from conventional neuroleptics. This article describes the drug's development/special monitoring and dispensing arrangements, and gives advice on how it can best be utilized.
Launer
M
M
Burnley Health Care Trust.
D000380:Agranulocytosis / Q000139:chemically induced; D002986:Clinical Trials as Topic; D003024:Clozapine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D016903:Drug Monitoring; D006801:Humans; D010342:Patient Acceptance of Health Care; D012559:Schizophrenia / Q000188:drug therapy*; D006113:United Kingdom
D003024:Clozapine