title: cdc2 kinase phosphorylation of desmin at three serine/threonine residues in the amino-terminal head domain.
abstract: Phosphorylation of desmin filament by cdc2 kinase induced a transition toward the depolymerized state of the filament. Sequence analysis of purified phosphopeptides derived from cdc2 kinase-phosphorylated desmin revealed that Ser-6, Ser-22 and Thr-64 in the N-terminal head domain were the sites phosphorylated.
authors.affiliation: Department of Neurophysiology, Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kusubata
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: K
authors.initials: K
authors.lastname: Tsujimura
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Kamijo
authors.forename: H
authors.initials: H
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ohba
authors.forename: E
authors.initials: E
authors.lastname: Okumura
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D002645:Chickens; D003893:Desmin / Q000737:chemistry / Q000378:metabolism*; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D010768:Phosphoserine / Q000378:metabolism; D010769:Phosphothreonine / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism
chemical_list: D003893:Desmin; D010750:Phosphoproteins; D010769:Phosphothreonine; D010768:Phosphoserine; D011494:Protein Kinases; D011493:Protein Kinase C; D016203:CDC2 Protein Kinase