title: Cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
abstract: A review of the cytogenetic analyses of a cohort of unselected patients with acute lymphoblastic leukemia from a single institution (1981-1989) confirmed hyperdiploidy > 50 as a favorable prognostic feature and pseudodiploidy, especially with chromosomal rearrangements, as an adverse one. In the early years of the study, a high incidence of diploid karyotype was identified, but with time (better banding and more intensive search) the incidence has fallen to 7.7%. Many such patients have been shown to be pseudodiploid. Molecular genetic techniques are increasingly identifying clonal abnormalities.
authors.affiliation: Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom.
authors.forename: P D
authors.initials: PD
authors.lastname: Micallef-Eynaud
authors.forename: O B
authors.initials: OB
authors.lastname: Eden
authors.forename: E
authors.initials: E
authors.lastname: Grace
authors.forename: P M
authors.initials: PM
authors.lastname: Ellis
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D004171:Diploidy; D005260:Female; D006801:Humans; D007621:Karyotyping; D007958:Leukocyte Count; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000235:genetics* / Q000473:pathology; D011379:Prognosis