title: Prolonged use of isoflurane in a patient with tetanus.
abstract: We describe a patient with tetanus, who received isoflurane for sedation to facilitate controlled mechanical ventilation. Isoflurane was administered for 34 days, resulting in a sustained serum inorganic fluoride ion concentration in excess of 50 mumol litre-1 and a peak serum inorganic fluoride ion concentration of 87 mumol litre-1. Although these concentrations are potentially nephrotoxic, no toxicity was evident clinically.
authors.affiliation: Ipswich Hospital.
authors.forename: J J
authors.initials: JJ
authors.lastname: Stevens
authors.forename: R M
authors.initials: RM
authors.lastname: Griffin
authors.forename: P J
authors.initials: PJ
authors.lastname: Stow
mesh_terms: D000328:Adult; D005459:Fluorides / Q000097:blood; D006801:Humans; D007530:Isoflurane; D008134:Long-Term Care; D008297:Male; D012121:Respiration, Artificial; D013742:Tetanus / Q000097:blood / Q000628:therapy*; D013997:Time Factors
chemical_list: D007530:Isoflurane; D005459:Fluorides