Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects.
The authors administered 48 mg of intravenous cocaine or placebo to eight abstinent cocaine users in a double-blind, crossover design and examined blood flow using single photon emission computed tomography. Cocaine produced significant decreases in frontal cortical and basal ganglia blood flow; these latter correlated negatively with increases in self-ratings of "rush" and "high." The authors conclude that these local effects are compatible with dopaminergic system involvement.
Pearlson
G D
GD
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21287-7362.
Jeffery
P J
PJ
Harris
G J
GJ
Ross
C A
CA
Fischman
M W
MW
Camargo
E E
EE
D000328:Adult; D000339:Affect / Q000187:drug effects*; D001479:Basal Ganglia / Q000098:blood supply / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D004311:Double-Blind Method; D005625:Frontal Lobe / Q000098:blood supply / Q000187:drug effects; D006801:Humans; D008297:Male; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D019966:Substance-Related Disorders / Q000503:physiopathology / Q000523:psychology*; D015899:Tomography, Emission-Computed, Single-Photon
D011954:Receptors, Dopamine; D003042:Cocaine