Sodium lactobionate sucrose solution for canine liver and kidney preservation.
With 24-hour preservation of canine liver, SLS solution showed inferior animal survival to UW solution. The lactobionate, raffinose, glutathione, and hydroxyethyl starch in UW solution have been shown to be important for liver preservation. However, our results suggest that sucrose should not be substituted for raffinose for the preservation of livers. In contrast to the liver, SLS solution performed the same or even better than UW solution for kidney preservation. The substitution of sucrose for raffinose, along with the addition of CPZ has either no effect or a slightly positive effect on kidney preservation. In conclusion, SLS solution may be a suitable solution for preserving canine kidneys, but is not suitable for liver preservation. These findings suggest that future development of preservation solutions should be focused on the needs of specific organs and not toward a generic, all encompassing preservation solution.
Zhu
Y
Y
Pittsburgh Transplant Institute, University of Pittsburgh, Pennsylvania.
Furukawa
H
H
Nakamura
K
K
Hamamoto
I
I
Wu
Y
Y
Xiaoshan
R
R
Venkataramanan
R
R
Todo
S
S
Starzl
T E
TE
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002746:Chlorpromazine; D004187:Disaccharides; D004285:Dogs; D005260:Female; D006085:Graft Survival; D016030:Kidney Transplantation / Q000379:methods / Q000502:physiology*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods / Q000502:physiology*; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D012996:Solutions; D013395:Sucrose / Q000031:analogs & derivatives; D013997:Time Factors
D001786:Blood Glucose; D004187:Disaccharides; D019188:Organ Preservation Solutions; D012996:Solutions; C067074:sodium lactobionate sucrose solution; D013395:Sucrose; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D002746:Chlorpromazine