title: Prognosis for keratoplasty in Acanthamoeba keratitis.
abstract: METHODS
  Penetrating keratoplasty (PK) was undertaken between 1985-1991 at Moorfields Eye Hospital in 13 eyes (19 PKs) of 11 patients who developed Acanthamoeba keratitis. Infection was ultimately controlled in all cases. Retrospective analysis was undertaken to establish risk factors for PK. Six eyes were quiet and 7 had uncontrolled infection at the time of keratoplasty. The outcome for these was compared.
  
  
  RESULTS
  Complications included cataract in 50% of quiet eyes and 100% of inflamed eyes. Intumescent cataract resulted in glaucoma requiring drainage surgery in 4 eyes. Graft rejection episodes occurred in 50% of quiet eyes, but were treated aggressively and did not cause graft failure.
  
  
  RESULTS
  Graft survival was excellent for quiet eyes, but was compromised by recurrent infection in inflamed eyes and 6 patients were regrafted. Survival compared poorly with grafting for active herpetic or bacterial keratitis, indicating that early diagnosis and treatment are essential for adequate control of this disease.
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom.
authors.forename: L A
authors.initials: LA
authors.lastname: Ficker
authors.forename: C
authors.initials: C
authors.lastname: Kirkness
authors.forename: P
authors.initials: P
authors.lastname: Wright
mesh_terms: D015823:Acanthamoeba Keratitis / Q000209:etiology / Q000601:surgery*; D000328:Adult; D003261:Contact Lenses / Q000009:adverse effects; D006085:Graft Survival; D006801:Humans; D015948:Keratoplasty, Penetrating; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014792:Visual Acuity