Pulmonary granulomata. A complication of intravesical administration of bacillus Calmette-Guerin for superficial bladder carcinoma.
Intravesical administration of bacillus Calmette-Guerin (BCG) is an effective treatment for superficial carcinoma of the bladder. The authors report a pulmonary complication characterized by miliary infiltration on chest roentgenogram and caseating granulomata on lung biopsy specimens. This case and three prior reports suggest that this complication may be a form of hypersensitivity rather than true BCG infection.
Smith
R L
RL
Department of Medicine, Department of Veterans Affairs Medical Center, New York, NY 10010.
Alexander
R F
RF
Aranda
C P
CP
D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D002291:Carcinoma, Papillary / Q000628:therapy*; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
D001500:BCG Vaccine