Subclinical affection of liver and kidney function and solvent exposure.
The role of solvents as hepato- and nephrotoxic agents under present-day exposure levels is still unclear. The purpose of this study involving 99 metal degreasers was to examine dose-response relationships between long-term exposure of mainly trichloroethylene and a battery of liver function tests and one nephrotubular enzyme test. Serum gamma-glutamyltransferase and urinary N-acetyl-beta-glucosaminidase were elevated by increasing solvent exposure at bivariate level. The significance of this relationship, however, was not able to withstand a multiple regression analysis, with age and alcohol abuse as confounding variables. The conclusion is that of a nonsignificant association between solvent exposure and tests screening for early liver and kidney dysfunction.
Rasmussen
K
K
Institute of Epidemiology and Social Medicine, University of Aarhus, Denmark.
Brogren
C H
CH
Sabroe
S
S
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008111:Liver Function Tests; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D014241:Trichloroethylene / Q000009:adverse effects*
D014241:Trichloroethylene