High gastric juice ascorbic acid concentrations in members of a gastric cancer family.
Gastric juice ascorbic acid, total vitamin C, nitrite and N-nitroso-compound concentrations were determined in fasting gastric juice from four second generation members of a gastric cancer family, all of whom had Helicobacter pylori-associated chronic gastritis and intestinal metaplasia. Juice pH, nitrite and N-nitroso-compound concentrations were low. Juice ascorbate levels were comparable to those found in subjects with normal histology. The findings are contrary to our previous experience with juice ascorbate in H. pylori gastritis.
Sobala
G M
GM
Centre for Digestive Diseases, General Infirmary, Leeds, UK.
Schorah
C J
CJ
Pignatelli
B
B
Crabtree
J E
JE
Martin
I G
IG
Scott
N
N
Quirke
P
P
D000328:Adult; D001205:Ascorbic Acid / Q000032:analysis*; D005192:Family Health; D005750:Gastric Juice / Q000737:chemistry*; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009573:Nitrites / Q000032:analysis; D009603:Nitroso Compounds / Q000032:analysis; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics / Q000378:metabolism*
D009573:Nitrites; D009603:Nitroso Compounds; D001205:Ascorbic Acid