title: The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region.
abstract: The gene for human interleukin-1 receptor antagonist (IL1RN) has been assigned to chromosome 2 on the basis of Southern blot analysis of a series of human-Chinese hamster cell hybrids. Using a yeast artificial chromosome containing the IL1RN gene as a probe, the human IL1RN gene was localized to the long arm of chromosome 2 at band 2q14.2 by fluorescence in situ hybridization. This site is near the positions of genes for human IL-1 alpha, IL-1 beta, and types I and II IL-1 receptors, as reported by other laboratories.
authors.affiliation: Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206.
authors.forename: D
authors.initials: D
authors.lastname: Patterson
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: I
authors.initials: I
authors.lastname: Hart
authors.forename: J
authors.initials: J
authors.lastname: Bleskan
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: D
authors.initials: D
authors.lastname: Geyer
authors.forename: S P
authors.initials: SP
authors.lastname: Eisenberg
authors.forename: M F
authors.initials: MF
authors.lastname: Smith
authors.forename: W P
authors.initials: WP
authors.lastname: Arend
mesh_terms: D000818:Animals; D001483:Base Sequence; D016466:CHO Cells; D002874:Chromosome Mapping; D015825:Chromosomes, Fungal; D002889:Chromosomes, Human, Pair 2; D006224:Cricetinae; D004277:DNA, Single-Stranded; D015894:Genome, Human; D015698:Genomic Library; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*
chemical_list: D004277:DNA, Single-Stranded; D017472:Receptors, Interleukin-1