Effect of Rumalon (glycosaminoglycan-peptide) on the articular tissue.
The effect of glycosaminoglycan-peptide complex (GPC) (Rumalon, made by Robapharm, Switzerland) on cells of the inflammatory periarticular infiltrate and on the articular chondrocytes was studied in experimentally induced papain arthropathy by means of image cytometry and biochemistry. The GPC therapy exhibited some antiinflammatory effect as documented by the reduction of DNA proliferative activity in the inflammatory infiltrate and lowered the activity of hydrolytic enzymes and enzyme inhibitors detected in chondrocytes.
Skrivánková
B
B
Institute of Rheumatology, Praha, Czechoslovakia.
Julis
I
I
Podrazký
V
V
Trnavský
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000473:pathology*; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D002682:Chinchilla; D004247:DNA / Q000032:analysis; D010450:Endopeptidases / Q000032:analysis; D005347:Fibroblasts / Q000187:drug effects; D006868:Hydrolysis; D008214:Lymphocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D010206:Papain; D011480:Protease Inhibitors / Q000494:pharmacology; D011817:Rabbits; D014020:Tissue Extracts / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011480:Protease Inhibitors; D014020:Tissue Extracts; C000562:Rumalon; D004247:DNA; D010450:Endopeptidases; D010206:Papain