title: Inhibitory effects of tea extracts and (-)-epigallocatechin gallate on DNA synthesis and proliferation of hepatoma and erythroleukemia cells.
abstract: Polyphenols extracted from green or black tea with ethyl acetate were strongly inhibitory for DNA synthesis in HTC rat hepatoma cells and DS19 mouse erythroleukemia cells at concentrations of 0.1-0.2 mg/ml. There was less inhibition with a subsequent black tea fraction extracted with butanol and with the residual water-soluble fraction. Although cell proliferation was inhibited by (-)-epigallocatechin gallate and the tea extracts, there were only marginal effects on differentiation of DS19 cells as judged by hemoglobin synthesis.
authors.affiliation: Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark 07103.
authors.forename: M A
authors.initials: MA
authors.lastname: Lea
authors.forename: Q
authors.initials: Q
authors.lastname: Xiao
authors.forename: A K
authors.initials: AK
authors.lastname: Sadhukhan
authors.forename: S
authors.initials: S
authors.lastname: Cottle
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
mesh_terms: D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D006454:Hemoglobins / Q000096:biosynthesis; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013662:Tea
chemical_list: D004273:DNA, Neoplasm; D006454:Hemoglobins; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate