title: Structure of the HLA class I region and expression of its resident genes.
abstract: The past year has seen several advances in the analysis of the HLA class I region and some of its resident genes. A description of the human class I gene family and the cloning of the class I region in yeast artificial chromosomes have provided two steps forward in the analysis of the class I region. Advances have been made in understanding the expression of the non-classical HLA class Ib genes and work with the murine class Ib proteins has demonstrated that these antigens can present a specialized subset of peptides to the immune system.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: D E
authors.initials: DE
authors.lastname: Geraghty
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D051379:Mice
chemical_list: D006183:H-2 Antigens; D006680:HLA Antigens