Postoperative nausea and vomiting: a comparison of anti-emetic drugs used alone or in combination.
Drugs with anti-emetic properties can exert their actions at more than one receptor site, histamine H1, muscarinic cholinergic or dopaminergic D2 receptors. This study was designed to test the hypothesis that a combination of drugs acting at different receptor sites in lower than standard doses would be at least as effective as a standard therapeutic dose of a single anti-emetic agent. A combination of droperidol, hyoscine and metoclopramide in subtherapeutic doses has been shown to be at least as effective as droperidol (1.25 mg) alone. In both groups there was a low incidence of emetic sequelae in the first 3 hours postoperatively.
Michaloudis
D
D
Department of Anaesthesia, Withington Hospital, Manchester.
O'Keeffe
N
N
O'Sullivan
K
K
Healy
T E
TE
D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D008787:Metoclopramide / Q000627:therapeutic use; D009325:Nausea / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D012601:Scopolamine / Q000627:therapeutic use; D014839:Vomiting / Q000517:prevention & control*
D000932:Antiemetics; D004338:Drug Combinations; D012601:Scopolamine; D008787:Metoclopramide; D004329:Droperidol