title: Immune response in mice that lack the interferon-gamma receptor.
abstract: Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
authors.affiliation: Institute of Molecular Biology I, University of Zürich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Hendriks
authors.forename: A
authors.initials: A
authors.lastname: Althage
authors.forename: S
authors.initials: S
authors.lastname: Hemmi
authors.forename: H
authors.initials: H
authors.lastname: Bluethmann
authors.forename: R
authors.initials: R
authors.lastname: Kamijo
authors.forename: J
authors.initials: J
authors.lastname: Vilcek
authors.forename: R M
authors.initials: RM
authors.lastname: Zinkernagel
authors.forename: M
authors.initials: M
authors.lastname: Aguet
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D007109:Immunity; D007074:Immunoglobulin G / Q000097:blood; D007371:Interferon-gamma / Q000502:physiology*; D008088:Listeriosis / Q000276:immunology; D016131:Lymphocyte Subsets; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation; D017471:Receptors, Interferon / Q000235:genetics / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014615:Vaccinia / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D017471:Receptors, Interferon; D007371:Interferon-gamma