Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94.
The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2-->q24.3), and 15 (q25-->q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designated TRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 and TRAP2) appear to be independently derived, processed pseudogenes.
Maki
R G
RG
Department of Pharmacology, Mount Sinai School of Medicine, CUNY, New York 10029.
Eddy
R L
RL
Byers
M
M
Shows
T B
TB
Srivastava
P K
PK
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D004247:DNA; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011544:Pseudogenes
D000951:Antigens, Neoplasm; D006360:Heat-Shock Proteins; D008562:Membrane Glycoproteins; C052646:sarcoma glycoprotein gp96 rejection antigens; D004247:DNA