Cyclosporine preferentially inhibits clonal deletion of CD8-positive T cells with an MHC class II restricted autoreactive T-cell receptor.
Severino
M E
ME
Johns Hopkins Bone Marrow Transplant Unit, Baltimore, Maryland.
Laulis
M K
MK
Horwitz
L R
LR
Hess
A D
AD
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology*; D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D016130:Immunophenotyping; D008212:Lymphocyte Depletion; D051381:Rats; D011917:Rats, Inbred Lew; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D016827:CD8 Antigens; D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016572:Cyclosporine