Glucose effects on oxygen consumption by the arterial wall.
The effect of both D- and L-glucose on the rate of oxygen consumption in rat aorta was determined. Oxygen uptake (V02) was found to decrease when the concentration of D-glucose in the medium was increased, with the same effect being found when L-glucose, rather than D-glucose, was used. Based on these results, it would appear that the decrease in the vascular wall oxygen consumption which results from increased glucose levels is not due to a metabolic effect since one of the isomers (D) is metabolized and the other (L) is not. It is suggested, instead, that these results may be be due to a change in the diffusion of oxygen. Possible implications for atherogenesis are also discussed.
Massaldi
H A
HA
Department of Chemical Engineering, University of Virginia, Charlottesville 22903-2442.
Gainer
J L
JL
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D005947:Glucose