title: Giant collagen plaques in Creutzfeld-Jakob disease. Report of two cases with ultrastructural studies.
abstract: We report two cases of Creutzfeld-Jakob disease with clusters of giant collagen fibers. To our knowledge, these abnormally large collagen fibers have never been described in patients with degenerative diseases of the central nervous system. The significance of the formation of such plaque-like large collagen fibers has as yet not been elucidated. It is felt that these represent a product of the degenerative process.
authors.affiliation: Department of Pathology, New York Medical College, Metropolitan Hospital Center, NY 10029.
authors.forename: T P
authors.initials: TP
authors.lastname: Poon
authors.forename: V
authors.initials: V
authors.lastname: Tchertkoff
authors.forename: M
authors.initials: M
authors.lastname: de Jesus
authors.forename: A
authors.initials: A
authors.lastname: Lahiri
authors.forename: T
authors.initials: T
authors.lastname: Lansen
mesh_terms: D000328:Adult; D001921:Brain / Q000648:ultrastructure*; D003094:Collagen / Q000378:metabolism*; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
chemical_list: D003094:Collagen