title: Evidence for biventricular involvement in acromegaly: a Doppler echocardiographic study.
abstract: To investigate left and right ventricular involvement in acromegaly, 20 patients were studied by Doppler echocardiography. Nine of them had systemic hypertension. Right ventricular free wall thickness was significantly increased in acromegalic patients (8 +/- 2 vs 4 +/- 1 mm; P < 0.001). Left ventricular mass index was augmented both in the whole group and in the subgroup of normotensive acromegalics, as compared with normals (134 +/- 33 and 115 +/- 20 vs 80 +/- 18 g.m-2; P < 0.01). Ejection phase indices were normal in the patient group, while impaired left and right ventricular diastolic filling was found. In fact isovolumic relaxation time was prolonged (118 +/- 21 vs 78 +/- 12 ms; P < 0.001), ratio of early to late mitral (0.9 +/- 0.3 vs 1.8 +/- 0.5; P < 0.001) and tricuspid (1.0 +/- 0.2 vs 1.4 +/- 0.3; P < 0.001) flow velocities were significantly decreased as compared with controls. Superior vena cava flowmetry was also abnormal showing a marked decrease of diastolic filling wave and, consequently, of the ratio between peak diastolic and peak systolic flow velocity. No significant differences were observed between normotensive and hypertensive acromegalics, except for left ventricular mass index (115 +/- 20 vs 156 +/- 31 g.m-2; P < 0.01). These findings indicate that abnormal diastolic filling patterns of transmitral, transtricuspid, and superior vena cava flowmetry suggesting 'impaired relaxation' associated with increased left and right ventricular mass, frequently occur in acromegaly.
authors.affiliation: Department of Internal Medicine, Federico II University, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Fazio
authors.forename: A
authors.initials: A
authors.lastname: Cittadini
authors.forename: D
authors.initials: D
authors.lastname: Sabatini
authors.forename: B
authors.initials: B
authors.lastname: Merola
authors.forename: A M
authors.initials: AM
authors.lastname: Colao
authors.forename: B
authors.initials: B
authors.lastname: Biondi
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
authors.forename: L
authors.initials: L
authors.lastname: Saccá
mesh_terms: D000172:Acromegaly / Q000000981:diagnostic imaging* / Q000503:physiopathology; D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D015924:Blood Pressure Monitors; D006332:Cardiomegaly / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015150:Echocardiography, Doppler; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014683:Vena Cava, Superior / Q000000981:diagnostic imaging / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone