title: Efficacy and safety of zonisamide: results of a multicenter study.
abstract: The safety and efficacy of zonisamide (ZNS), a new antiepileptic drug, was tested in 167 adult participants who entered a historical-controlled 16-week open label, multicenter study. The median percent reduction from baseline of partial seizures was 51.8% in the fourth month of the study (baseline median = 11.5 sz/month; treatment weeks 13-16 = 5.5 sz/month). Persons completing the efficacy study successfully were eligible for a long-term safety study; 113 entered this study. Adverse effects involved principally the CNS and were similar to those seen with other antiepileptic drugs. Four persons (3.7%) developed kidney stones and were withdrawn from the study 250-477 days after starting ZNS. Because of the high percentage of kidney stones, development of ZNS was stopped in the United States but was continued in Japan.
authors.affiliation: MINCEP Epilepsy Care, Minneapolis, MN 55416.
authors.forename: I E
authors.initials: IE
authors.lastname: Leppik
authors.forename: L J
authors.initials: LJ
authors.lastname: Willmore
authors.forename: R W
authors.initials: RW
authors.lastname: Homan
authors.forename: G
authors.initials: G
authors.lastname: Fromm
authors.forename: K J
authors.initials: KJ
authors.lastname: Oommen
authors.forename: J K
authors.initials: JK
authors.lastname: Penry
authors.forename: J C
authors.initials: JC
authors.lastname: Sackellares
authors.forename: D B
authors.initials: DB
authors.lastname: Smith
authors.forename: R P
authors.initials: RP
authors.lastname: Lesser
authors.forename: J D
authors.initials: JD
authors.lastname: Wallace
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide