Relationships among nutritional status and skeletal and respiratory muscle function in cystic fibrosis: does early dietary supplementation make a difference?
Relationships among nutritional status and skeletal and respiratory muscle function were examined in 16 children with cystic fibrosis (CF) and mild lung disease (FEV1 95 +/- 16% predicted). Subjects were randomly assigned to receive (or not) noninvasive nutritional supplementation at 25% of normal energy recommendations for 6 mo. Skeletal muscle strength and power were similar to those of healthy children as were respiratory muscle strength and endurance. Stepwise-regression analysis indicated that changes in skeletal muscle strength and energy intake correlated significantly with growth [weight (kg) = 1.90 - 0.60 (Tanner Stage) + 0.49 (maximum voluntary strength (Nm) + 0.03 (energy intake, % RNI), r = 0.76, P < 0.05], though body composition, protein biochemistry, muscle power, respiratory muscle strength, and use of dietary supplements did not. Thus, changes in skeletal muscle strength may be a functional index of changes in nutritional status in CF. Dietary supplementation per se was not associated with functional improvement.
Hanning
R M
RM
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Blimkie
C J
CJ
Bar-Or
O
O
Lands
L C
LC
Moss
L A
LA
Wilson
W M
WM
D000293:Adolescent; D000886:Anthropometry; D001823:Body Composition; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology*; D002149:Energy Intake; D015444:Exercise / Q000502:physiology; D006801:Humans; D009132:Muscles / Q000503:physiopathology*; D009752:Nutritional Status / Q000502:physiology*; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000503:physiopathology