Antioxidants prevent nickel chloride inhibition of cytochrome P450 dependent mixed function oxidation in guinea pig lung microsomes.
al-Assadi
H M
HM
Bioengineering Unit, Strathclyde University, Wolfson Centre, Glasgow, Scotland.
Rodgers
E H
EH
Grant
M H
MH
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000201:enzymology; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009532:Nickel / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; C022838:nickel chloride; D009532:Nickel; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001205:Ascorbic Acid