Characterization of atherosclerosis with a 1.5-T imaging system.
It is shown that a conventional 1.5-T magnetic resonance (MR) imaging system can help characterize some of the key components of atherosclerotic plaque ex vivo. Fresh human aorta with atheromata was suspended in solutions of agarose and manganese chloride and heated to body temperature. The specimens were imaged with modified Dixon and projection-reconstruction imaging sequences. The specimens were then examined histologically to obtain direct correlation between images, spectra, and histologic characteristics. The results show that vessel wall and plaque components can be identified by means of their MR characteristics and correlated with their histologic appearance. The authors were able to identify normal vessel wall components, such as adventitial lipids and smooth muscle. They were also able to identify and localize plaque components such as fibrous tissue, calcification, lipids, and possible areas of hemorrhage and hemosiderin deposition.
Gold
G E
GE
Department of Radiology, Stanford University, CA 94305.
Pauly
J M
JM
Glover
G H
GH
Moretto
J C
JC
Macovski
A
A
Herfkens
R J
RJ
D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000378:metabolism / Q000473:pathology*; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D008297:Male