Blood volume distribution in lung injury.
Mild hydrochloric acid was used to induce injury in the caudal section of one lung in each of 10 dogs. 99mTc-red blood cells were injected intravenously. Blood samples were drawn prior to sacrifice. Lung and blood samples were weighed, assayed for radioactivity and dried to constant weight. Assuming a uniform hematocrit, and hence a constant density, we computed blood volumes in terms of mass. The control lung had 4.32 +/- 0.62 g of extravascular lung water (EVLW) per g of bloodless dried weight (BLDW). Injury in the other lung was characterized by an elevated average of 7.08 +/- 0.79 g of EVLW per g of BLDW. The control lung contained 2.49 +/- 0.43 g of blood per g of BLDW and the injured lung contained a reduced amount of 1.69 +/- 0.55 g of blood per g of BLDW. In 8 subjects, injured portions retained the least blood volume per g of BLDW (a limiting value of 1.43 +/- 0.47 g per g). These results support a thesis of a reduction of blood volume in an injured area.
Chu
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University of Oklahoma, Oklahoma City.
Sidhu
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N
Carlile
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D000818:Animals; D001810:Blood Volume; D001811:Blood Volume Determination / Q000379:methods; D004285:Dogs; D015633:Extravascular Lung Water / Q000378:metabolism*; D055370:Lung Injury