title: Osteoarthritis in rhesus macaques: assessment of cartilage matrix quality by quantitative magnetic resonance imaging.
abstract: To assess cartilage quality with anatomical location and extent of osteoarthritis (OA), magnetic resonance imaging (MRI) of the knee joint from rhesus monkeys was performed. MRI measurements--T1 and T2 relaxation times, proton density and cartilage thickness were taken from 8 equal segments of articular cartilage volumes extending from anterior to posterior edge of 1 mm sagittal slices. To grade the severity of OA in each quadrant of the knee joint a modified Mankin score was applied on the histological sections. Our results suggest that MR relaxation times and proton density values vary with the severity of osteoarthritis.
authors.affiliation: Department of Pathology, University of Toronto, Canada.
authors.forename: H K
authors.initials: HK
authors.lastname: Gahunia
authors.forename: C
authors.initials: C
authors.lastname: Lemaire
authors.forename: A R
authors.initials: AR
authors.lastname: Cross
authors.forename: P
authors.initials: P
authors.lastname: Babyn
authors.forename: M J
authors.initials: MJ
authors.lastname: Kessler
authors.forename: K P
authors.initials: KP
authors.lastname: Pritzker
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D007719:Knee Joint / Q000473:pathology; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D010003:Osteoarthritis / Q000473:pathology*