title: Reduction of bacterial titers by low-dose aspirin in experimental aortic valve endocarditis.
abstract: Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial titer of the vegetations.
authors.affiliation: Department of Pharmacy, Hartford Hospital, Connecticut 06115.
authors.forename: D P
authors.initials: DP
authors.lastname: Nicolau
authors.forename: C D
authors.initials: CD
authors.lastname: Freeman
authors.forename: C H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: R
authors.initials: R
authors.lastname: Quintiliani
authors.forename: C J
authors.initials: CJ
authors.lastname: Coe
authors.forename: E G
authors.initials: EG
authors.lastname: Maderazo
authors.forename: B W
authors.initials: BW
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000382:microbiology; D001241:Aspirin / Q000627:therapeutic use*; D001422:Bacterial Adhesion / Q000187:drug effects; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D011817:Rabbits; D013211:Staphylococcus aureus
chemical_list: D001241:Aspirin