title: Androgen receptor and mechanism of androgen action.
abstract: Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner. The present overview describes the structurally important domains of the receptor protein, and discusses several aspects in the structure-function relationship, using naturally occurring receptor mutants in androgen insensitivity patients or experimental animals as examples. In addition, characteristics of androgen receptor expressed in a heterologous system are described, and their potential usefulness in specific molecular studies discussed.
authors.affiliation: Department of Physiology, University of Helsinki, Finland.
authors.forename: O A
authors.initials: OA
authors.lastname: Jänne
authors.forename: J J
authors.initials: JJ
authors.lastname: Palvimo
authors.forename: P
authors.initials: P
authors.lastname: Kallio
authors.forename: M
authors.initials: M
authors.lastname: Mehto
mesh_terms: D000728:Androgens / Q000502:physiology*; D000818:Animals; D016367:Baculoviridae / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology; D015533:Transcriptional Activation
chemical_list: D000728:Androgens; D011944:Receptors, Androgen