title: Generalized juvenile polyposis with mixed pattern and gastric cancer.
abstract: Generalized gastrointestinal juvenile polyposis is a rare form of diffuse polyposis in which cancer infrequently develops. A clinical case is described in which gastric polyps showed a variety of histological features, including both in situ and invasive adenocarcinoma. Many mixed lesions were observed, confirming a morphological sequence already documented in colorectal tumorigenesis but still undefined in gastric tumors. The patient seems strongly predisposed to gastric cancer, presumably on a genetic basis, because he developed a malignancy in a hyperplastic juvenile polyp, usually not considered a precancerous lesion. There is no doubt that cases like this may be important for accurate genetic evaluation and biological characterization.
authors.affiliation: Institute of Internal Medicine, University of Modena, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Sassatelli
authors.forename: G
authors.initials: G
authors.lastname: Bertoni
authors.forename: L
authors.initials: L
authors.lastname: Serra
authors.forename: G
authors.initials: G
authors.lastname: Bedogni
authors.forename: M
authors.initials: M
authors.lastname: Ponz de Leon
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology*; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011127:Polyps / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*