Excitation induced by acetylcholine after injection of Limulus ventral photoreceptor with ml muscarinic receptor mRNA.
We investigated whether a human neurotransmitter receptor for acetylcholine (Ach) could couple Ach to light-sensitive pathways in Limulus photoreceptors. Two to three days after injection of human ml muscarinic mRNA into Limulus ventral photoreceptors the cells depolarized in response to Ach.
Zhang
Z X
ZX
Department of Physiology, University of Connecticut Health Center, Farmington 06030.
Segerson
T P
TP
Fein
A
A
D000109:Acetylcholine / Q000494:pharmacology*; D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D006737:Horseshoe Crabs; D015544:Inositol 1,4,5-Trisphosphate / Q000096:biosynthesis*; D008564:Membrane Potentials / Q000187:drug effects; D008845:Microinjections; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000187:drug effects*; D012333:RNA, Messenger / Q000494:pharmacology*; D011976:Receptors, Muscarinic / Q000235:genetics*
D012333:RNA, Messenger; D011976:Receptors, Muscarinic; D015544:Inositol 1,4,5-Trisphosphate; D000109:Acetylcholine