Immunohistology of eye muscle in idiopathic orbital inflammatory disease (pseudotumor), Graves' ophthalmopathy and healthy controls.
Inflammatory orbital disease can be triggered by a variety of causes. Two such diseases are pseudotumor orbitae and Graves' ophthalmopathy, and both involve extraocular muscles. Biopsies were obtained from ocular muscles during a quiet phase in these two diseases. Biopsies obtained from a previous pseudotumor orbitae showed complement deposits and increased expression of HLA class-I antigens in the intermuscular tissue. The biopsies from two out of four pseudotumor cases and two out of four Graves' ophthalmopathy cases contained increased numbers of intermuscular HLA class-II-expressing cells. In spite of clinical remission, the local condition in all four pseudotumor cases and in two out of four cases of Graves' ophthalmopathy still suggests active inflammatory disease.
Lenderink
T
T
Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
Jager
M J
MJ
Bruijn
J A
JA
de Keizer
R J
RJ
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D001706:Biopsy; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006111:Graves Disease / Q000378:metabolism* / Q000473:pathology; D006684:HLA-DR Antigens / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000378:metabolism* / Q000473:pathology; D016727:Orbital Pseudotumor / Q000378:metabolism* / Q000473:pathology
D000911:Antibodies, Monoclonal; D003176:Complement C3; D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I