title: Comparative in vivo study on the healing qualities of four different presealed vascular prostheses.
abstract: OBJECTIVE
  The purpose of this article is to assess the healing qualities of presealed knitted polyester prostheses.
  
  
  METHODS
  Thoracic aortic replacement was performed with grafts with four different coating materials-collagen (CP), albumin (AP), and two with gelatin (GP1/GP2)-in four groups of 15 pigs each. Two weeks, 6 weeks, and 6 months after operation, five pigs of each group were killed. Healing quality was assessed by morphometric analysis of the remaining coating, the extent of tissue ingrowth, and the thickness of the inner layer.
  
  
  RESULTS
  The sealant was rapidly absorbed in all prostheses except for the AP (remaining coating at 2 weeks: GP1 22.1%, GP2 34.7%, and CP 68.0% vs AP 97.1% [p < 0.05]), remaining coating at 6 weeks: GP1/GP2 0% and CP 2.5% vs AP 76.7% (p < .01). At 6 months, remaining coating was only detectable in AP (21.5%). At 2 weeks the extent of tissue ingrowth ranged from 65.7% in GP1 and 75.3% in CP to 80% in GP2 versus 8.9% in AP (p < 0.05). There was a slow increase of tissue ingrowth until the sixth postoperative week (GP1 74.4%, GP2 85.0%, and CP 91.3% versus AP 19.6% [p < 0.01]). Thickness of the internal layer varied from 0.11 to 0.21 mm at 2 weeks in all grafts studied and from 1.02 mm (AP) and 1.28 mm (GP2) to 1.39 mm (GP1), versus 0.41 mm in the CP (p < 0.01) after 6 months of implantation.
  
  
  CONCLUSIONS
  The type of coating significantly influences the healing properties of knitted polyester prostheses. When used for thoracic aortic replacement in pigs, AP coating clearly results in inferior healing compared with GP1/GP2 or CP impregnation, with digestion of the coating material and tissue ingrowth used as parameters. The thinnest internal layer was found in the CP prostheses, reflecting superior healing properties of this coating in the model studied.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Federal Republic of Germany.
authors.forename: S W
authors.initials: SW
authors.lastname: Hirt
authors.forename: M
authors.initials: M
authors.lastname: Aoki
authors.forename: S
authors.initials: S
authors.lastname: Demertzis
authors.forename: F
authors.initials: F
authors.lastname: Siclari
authors.forename: A
authors.initials: A
authors.lastname: Haverich
authors.forename: H G
authors.initials: HG
authors.lastname: Borst
mesh_terms: D000042:Absorption; D000418:Albumins / Q000493:pharmacokinetics; D000704:Analysis of Variance; D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery; D001807:Blood Vessel Prosthesis; D003094:Collagen / Q000493:pharmacokinetics; D003238:Connective Tissue / Q000254:growth & development; D005780:Gelatin / Q000493:pharmacokinetics; D011474:Prosthesis Design; D013552:Swine; D013997:Time Factors
chemical_list: D000418:Albumins; D005780:Gelatin; D003094:Collagen