title: Pulmonary arterial changes in feline dirofilariasis.
abstract: Eleven cats with spontaneous dirofilariasis were necropsied; ten were domestic shorthairs and one was a Persian. The cats ranged in age from 1 to 10 years, and 6/11 cats were male. One to three heartworms were present in the right ventricle and pulmonary arteries of each of the 11 cats. Patchy areas of rugose thickening of the intima of the pulmonary trunk and marked villous endarteritis of lobar and medium-sized pulmonary arteries were observed. Affected larger vessels were partially occluded by large villous intimal proliferations that were lined by hyperplastic endothelial cells supported by connective tissue stroma. Moderate to marked infiltration of eosinophils and mononuclear inflammatory cells was consistently observed in the intima of affected larger pulmonary arteries. Thrombosis of pulmonary arteries was seen in five cats. Medial hypertrophy, mild intimal proliferative changes, and focal infiltrations of leukocytes were seen in small pulmonary arteries. Lesions indicative of right-sided heart failure consisting of right ventricular dilation and chronic passive congestion of the liver were observed in four cats.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville.
authors.forename: M D
authors.initials: MD
authors.lastname: McCracken
authors.forename: S
authors.initials: S
authors.lastname: Patton
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000469:parasitology / Q000473:pathology*; D002415:Cats; D004183:Dirofilaria immitis / Q000302:isolation & purification; D004184:Dirofilariasis / Q000150:complications / Q000469:parasitology / Q000473:pathology*; D005260:Female; D006965:Hyperplasia / Q000662:veterinary; D008174:Lung Diseases, Parasitic / Q000209:etiology / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011651:Pulmonary Artery / Q000469:parasitology / Q000473:pathology*