Cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
A review of the cytogenetic analyses of a cohort of unselected patients with acute lymphoblastic leukemia from a single institution (1981-1989) confirmed hyperdiploidy > 50 as a favorable prognostic feature and pseudodiploidy, especially with chromosomal rearrangements, as an adverse one. In the early years of the study, a high incidence of diploid karyotype was identified, but with time (better banding and more intensive search) the incidence has fallen to 7.7%. Many such patients have been shown to be pseudodiploid. Molecular genetic techniques are increasingly identifying clonal abnormalities.
Micallef-Eynaud
P D
PD
Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom.
Eden
O B
OB
Grace
E
E
Ellis
P M
PM
D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D004171:Diploidy; D005260:Female; D006801:Humans; D007621:Karyotyping; D007958:Leukocyte Count; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000235:genetics* / Q000473:pathology; D011379:Prognosis