Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects.
The acute and chronic effects of a preparation of dried garlic powder (Sapec) in a total daily dose of 900 mg on fibrinolysis and platelet aggregation have been evaluated in a randomized, double-blind, placebo controlled cross-over study of 12 healthy subjects. Total euglobulin fibrinolytic activity and t-PA (tissue plasminogen activator) activity were significantly higher 4 and 6 h after garlic and placebo ingestion, and no differences were recorded between treatments. After 14 days of treatment, t-PA activity was significantly higher after garlic, with inter-treatment significance. No significant changes in PAI (Plasminogen Activator Inhibitor) activity and fibrinogen levels were recorded. Platelet aggregation induced by adenosine diphosphate and collagen, and especially beta-thromboglobulin (beta-TG) release after collagen stimulation were significantly inhibited 2 and 4 h after garlic ingestion; platelet aggregation values were also significantly lower after 7 and 14 days of garlic treatment. No significant changes were found in adenosine triphosphate release and serum TXB2 levels after acute garlic administration.
Legnani
C
C
Department of Angiology and Blood Coagulation, University Hospital S. Orsola, Bologna, Italy.
Frascaro
M
M
Guazzaloca
G
G
Ludovici
S
S
Cesarano
G
G
Coccheri
S
S
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D003094:Collagen / Q000494:pharmacology; D004311:Double-Blind Method; D005342:Fibrinolysis / Q000187:drug effects*; D005737:Garlic; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010946:Plants, Medicinal; D010960:Plasminogen Activators / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D013929:Thromboxane B2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000378:metabolism
D015849:Plasminogen Inactivators; D001620:beta-Thromboglobulin; D013929:Thromboxane B2; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003094:Collagen; D010960:Plasminogen Activators