A linkage study in seven breast cancer families.
Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.
Teare
M D
MD
Cancer Research Campaign Pediatric and Familial Cancer Research Group, Christie Hospital, Manchester, England.
Santibáñez-Koref
M F
MF
Wallace
S A
SA
White
G R
GR
Evans
D G
DG
Burnell
L D
LD
Harris
M
M
Howell
A
A
Birch
J M
JM
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010375:Pedigree; D011519:Proto-Oncogenes
D005819:Genetic Markers