title: Behavioral and cognitive effect of theophylline: a dose-response study.
abstract: The behavioral and cognitive effects of theophylline were studied in 14 asymptomatic asthmatic children. A double-blind crossover design was used with two dosage levels. Conners parent ratings suggest behavioral improvement by the second week of treatment, regardless of dosage or order of administration. No effects were found on cognitive measures. We conclude that the majority of behavior problems associated with theophylline occur during the induction phase, and that for most children behavior and attention problems rapidly return to baseline or improve.
authors.affiliation: Department of Psychiatry, University of Chicago, Illinois.
authors.forename: M A
authors.initials: MA
authors.lastname: Stein
authors.forename: C A
authors.initials: CA
authors.lastname: Lerner
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology; D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D002675:Child, Preschool; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D013806:Theophylline / Q000097:blood / Q000494:pharmacology*
chemical_list: D013806:Theophylline