Effects of cisapride on anorectal and vesicourethral function in spinal cord injured patients.
The effect of cisapride on constipation in para and tetraplegia is well known. We have investigated the effects of this prokinetic drug on anorectal activity and on the function of the lower urinary tract. One result of the anorectal study showed a significant increase in activity and a reduction in compliance of the ampulla. The urodynamic study demonstrated earlier and higher amplitude reflex contractions in hyperactive bladders; hypoactive bladders significantly reduced their compliance. No functional alterations of striated urethral sphincter were observed.
Carone
R
R
Department of Urology, Spinal Cord Injuries Centre, Torino, Italy.
Vercelli
D
D
Bertapelle
P
P
D001003:Anal Canal / Q000503:physiopathology; D020117:Cisapride; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008297:Male; D010880:Piperidines / Q000627:therapeutic use*; D012007:Rectum / Q000503:physiopathology; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications*; D014521:Urethra / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride