title: CA 19-9 as a prognostic index after resection for pancreatic cancer.
abstract: Serial serum CA 19-9 assays were performed in 30 consecutive patients who underwent resection for pancreatic cancer. Patients with preoperative CA 19-9 levels < 200 U/ml had significantly better prognosis than those with CA 19-9 > 200 U/ml (P < 0.001). Serum tumor marker normalized in 14 patients after tumor resection, and survival in this group was significantly higher than that of patients with persistently elevated CA 19-9 (P < 0.0001). Prognosis was also influenced by absence of lymph node metastases (P < 0.02) and radicality of resection (P < 0.005). Elevation of serum CA 19-9 levels after operation well predicted tumor recurrence from 1-10 months before clinical and radiological evidence. CA 19-9 determination is useful as a prognostic index after resection for pancreatic carcinoma and as a surveillance test in monitoring the efficacy of treatment.
authors.affiliation: Department of Surgery, University of Padua, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Sperti
authors.forename: C
authors.initials: C
authors.lastname: Pasquali
authors.forename: S
authors.initials: S
authors.lastname: Catalini
authors.forename: F
authors.initials: F
authors.lastname: Cappellazzo
authors.forename: B
authors.initials: B
authors.lastname: Bonadimani
authors.forename: R
authors.initials: R
authors.lastname: Behboo
authors.forename: S
authors.initials: S
authors.lastname: Pedrazzoli
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000601:surgery*; D011379:Prognosis; D012008:Recurrence; D012044:Regression Analysis; D016019:Survival Analysis
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate