Diabetic rat aorta responsiveness to D600 and nifedipine.
1. The responsiveness of aortic rings from 4 and 12 week streptozotocin-induced diabetic rats to D600 (Gallopamil) and nifedipine was studied. 2. The sensitivity and responsiveness to D600 were significantly enhanced (P < 0.05; 5-test, ANOVA; 9 d.f.) only in the 4 week diabetic preparations precontracted with noradrenaline. 3. Nifedipine-induced relaxations were significantly enhanced (P < 0.05-0.01; t-test, ANOVA; 8-12 d.f.) in all the diabetic (4 and 12 weeks) aortic preparations precontracted with both noradrenaline (10(-7) mol/L) and KCl (40 mmol/L) when compared with controls. 4. D600, unlike nifedipine, did not produce significant relaxation of diabetic aortic preparations precontracted with KCl (40 mmol/L) at both week 4 and 12 of the disease when compared with controls. 5. These results suggest that there is differential responsiveness of streptozotocin diabetic rat aorta to D600 and nifedipine.
Orie
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NN
Department of Physiology, College of Medical Sciences, University of Calabar, Nigeria.
Aloamaka
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CP
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005711:Gallopamil / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects
D005711:Gallopamil; D011189:Potassium Chloride; D009543:Nifedipine; D009638:Norepinephrine