title: Synthesis of low-toxicity, 5-deoxy-5-fluoro and 5-deoxy-5,5-difluoro derivatives of arbekacin and its analogs, and study of structure-toxicity relationships.
authors.affiliation: Institute of Bioorganic Chemistry, Kawasaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: T
authors.initials: T
authors.lastname: Shitara
authors.forename: S
authors.initials: S
authors.lastname: Umezawa
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: N
authors.initials: N
authors.lastname: Tomono
authors.forename: E
authors.initials: E
authors.lastname: Umemura
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D003837:Deoxy Sugars / Q000737:chemistry; D003982:Dibekacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D005461:Fluorine / Q000737:chemistry; D007928:Lethal Dose 50; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003837:Deoxy Sugars; D005461:Fluorine; D003982:Dibekacin; C031986:arbekacin