Relationship between the size and phospholipid content of low-density lipoproteins.
In studies performed in vivo and in vitro, it has been found that the Stokes' diameter of human low-density lipoproteins (LDL) correlates positively and significantly with the molar ratio of phospholipid/apo B in LDL but not with the LDL molar ratios of either cholesterol/apo B or triacylglycerol/apo B. It has been concluded that the phospholipid content of LDL is an important determinant of LDL size.
Barter
P J
PJ
Lipid Research Laboratory, Hanson Centre, Institute of Medical and Veterinary Science, Adelaide, Australia.
Rajaram
O V
OV
Liang
H Q
HQ
Rye
K A
KA
D001055:Apolipoproteins B / Q000032:analysis*; D002784:Cholesterol / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D008077:Lipoproteins, LDL / Q000737:chemistry* / Q000302:isolation & purification; D008970:Molecular Weight; D010743:Phospholipids / Q000032:analysis*; D011719:Pyrazines / Q000627:therapeutic use; D014280:Triglycerides / Q000032:analysis
D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D010743:Phospholipids; D011719:Pyrazines; D014280:Triglycerides; D002784:Cholesterol; C027696:acipimox