Metformin and liver glycogen synthase activity in obese Zucker rats.
The effect of chronic treatment with metformin (320 mg/kg/day) on plasma glucose and insulin as well as liver glycogen synthase activity and hepatic glycogen content was studied in obese hyperinsulinemic Zucker rats. Metformin significantly reduced both plasma glucose (by 10%) and insulin levels (by 39%) at fasting but had no effect on hepatic glycogen content or on the basal activity of liver glycogen synthase.
Huupponen
R
R
Department of Clinical Pharmacology, University of Turku, Finland.
Pyykkö
K
K
Koulu
M
M
Rouru
J
J
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism*; D006946:Hyperinsulinism / Q000188:drug therapy / Q000201:enzymology*; D007333:Insulin Resistance; D008099:Liver / Q000201:enzymology*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D009765:Obesity / Q000201:enzymology*; D051381:Rats; D011924:Rats, Zucker
D001786:Blood Glucose; D008112:Liver Glycogen; D008687:Metformin; D006006:Glycogen Synthase