Can pharmacological intervention improve the visualization of the reticuloendothelial system using 99mTc-labeled albumin nanocolloid to that achievable with 111In-labeled granulocytes? Experimental studies in mice.
The use of 99mTc-colloids for bone marrow scintigraphy is limited by a high liver uptake, which hampers the evaluation of surrounding skeletal structures. In an experimental mouse system, different measures to increase the bone marrow activity in relation to the liver activity have been tested. A slightly positive, but significant, outcome was achieved by three different measures, namely fasting, pretreatment with a calcium-blocking pharmaceutical (Nimodipine) and pretreatment with large amounts of a gelatine colloid. It is concluded that the possibilities of dramatically improving the bone marrow uptake of a colloid compared to the liver are limited and not comparable to that achievable using radiolabeled granulocytes.
Kalin
B
B
Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
Schnell
P O
PO
Jacobsson
H
H
D000818:Animals; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D006098:Granulocytes / Q000000981:diagnostic imaging*; D007205:Indium Radioisotopes / Q000493:pharmacokinetics*; D008099:Liver / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009553:Nimodipine / Q000494:pharmacology; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D013668:Technetium Tc 99m Aggregated Albumin / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D007205:Indium Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin; D009553:Nimodipine