title: Use of carbon-11 acetate and dynamic positron emission tomography to assess regional myocardial oxygen consumption in patients with acute myocardial infarction receiving thrombolysis or coronary angioplasty.
abstract: Carbon-11 (C-11) acetate has been introduced for the noninvasive measurements of myocardial oxygen consumption. This study was designed to assess regional C-11 acetate clearance in patients with acute myocardial infarction. Thirty-one patients were studied within 8 days of acute myocardial infarction. C-11 acetate washout-rate constants were significantly lower in the infarct territory than in the remote myocardium (p < 0.008). The scintigraphic measurements correlated with heart rate-blood pressure product in the remote as well as infarct areas (0.52 and 0.48, respectively). There was no significant correlation to left ventricular ejection fraction. C-11 washout rates were significantly affected by beta-receptor therapy as assessed by multiple regression analysis. Thus, C-11 acetate kinetics allow noninvasive characterization of regional myocardial oxygen demand, which may be useful in assessing the extent of myocardial injury and myocardial oxygen demand of remote myocardium.
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor.
authors.forename: V
authors.initials: V
authors.lastname: Kalff
authors.forename: R J
authors.initials: RJ
authors.lastname: Hicks
authors.forename: G
authors.initials: G
authors.lastname: Hutchins
authors.forename: E
authors.initials: E
authors.lastname: Topol
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001794:Blood Pressure / Q000502:physiology; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy*; D015588:Observer Variation; D010101:Oxygen Consumption / Q000502:physiology*; D012016:Reference Values; D013318:Stroke Volume / Q000502:physiology; D015912:Thrombolytic Therapy; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes