[Influence of the permeability of the artery responsible for the infarction on the variability of heart rate and late potentials. Its importance in the risk stratification after myocardial infarction].
The use of the heart rate variability for the study of the Autonomic nervous system has been well established. We analyzed late potentials and heart rate variability in 29 control patients and in 102 consecutive patients with a first myocardial infarction. The data obtained were analyzed with both, the medical treatment (thrombolysis and beta-blockers) and the patency of the infarct related vessel. Patients with an infarct had diminished vagal tone as compared with the control group. Those patients with occluded related arteries showed higher incidence of late potentials; interestingly patients with late potentials also had diminished vagal tone. Without looking at the patency of the infarct related artery, thrombolitic and betablocker therapy did not have any effect on vagal tone. All the variables were correlated with the patency of the infarct related artery. Those patients with patent arteries had a preservation of the vagal tone; this was independent of the treatment received and the presence of late potentials. We concluded that the patency of the infarct related artery determines the absence of late potentials and preservation of the vagal tone. This might be one of the mechanisms of how thrombolitic therapy decreases the incidence of cardiac death.
Dorado
M
M
Departamento de Electrocardiografía y Electrofisiología, Instituto Nacional de Cardiología Ignacio Chávez, México, DF.
González-Hermosillo
J A
JA
García Arenal
F
F
Colín
L
L
Kershenovich
S
S
Romero
L
L
Iturralde
P
P
D000200:Action Potentials; D000328:Adult; D000368:Aged; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D012307:Risk Factors; D014630:Vagus Nerve / Q000503:physiopathology; D014654:Vascular Patency; D016276:Ventricular Function