Cortical spreading depression blocks prostaglandin E1 and endotoxin fever in rats.
We have tested the hypothesis that the cortex may play a role in the development of fever. Male Sprague-Dawley rats equipped with AM transmitters for telemetric measurement of body temperature were given intracerebroventricular prostaglandin E1 (PGE1), corticotropin-releasing hormone (CRH), or intravenous E. coli endotoxin. Application of cotton pellets soaked with 3.3 M KCl to the frontal cortex (to induce spreading depression) significantly reduced fevers to PGE1 and endotoxin when compared with fever magnitude with 0.9% NaCl application to the cortex. Neither CRH-induced hyperthermia nor normal body temperatures were altered by the spreading depression. Our results reveal a novel action of spreading depression on thermoregulatory function and indicate cortical involvement in the development of fever.
Monda
M
M
Neuroscience Research Group, University of Calgary, Alberta, Canada.
Pittman
Q J
QJ
D000527:Alprostadil / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D013181:Cortical Spreading Depression / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D004731:Endotoxins; D004926:Escherichia coli; D005334:Fever / Q000139:chemically induced*; D007276:Injections, Intraventricular; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D004731:Endotoxins; D011189:Potassium Chloride; D003346:Corticotropin-Releasing Hormone; D000527:Alprostadil