A negative association of schizophrenia with an allele of the HLA DQB1 gene among African-Americans.
Using polymorphisms of the human leukocyte antigen (HLA) DQB1 gene, a case-control study was conducted in a group of patients with schizophrenia (DSM-III, n = 58) and psychiatrically normal controls matched for ethnicity (n = 72), living in the same geographical area. A significant negative association of allele HLA DQB1*0602 with schizophrenia was present among African-Americans (odds ratio 0.19), but could not be detected in Caucasians.
Nimgaonkar
V L
VL
University of Pittsburgh, School of Medicine, Department of Psychiatry, PA 15208.
Ganguli
R
R
Rudert
W A
WA
Vavassori
C
C
Rabin
B S
BS
Trucco
M
M
D000328:Adult; D000483:Alleles; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D044383:Black People / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D005810:Multigene Family / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D012565:Schizophrenic Psychology; D001741:Black or African American
D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen