title: Placental and fetal Doppler velocimetry in pregnancies complicated by maternal diabetes mellitus.
abstract: OBJECTIVE
  Our purpose was to investigate placental and fetal circulation in pregnancies complicated by maternal diabetes mellitus and to relate any changes to fetal blood pH, Po2, and hematocrit.
  
  
  METHODS
  Doppler measurements of both uterine arteries, one umbilical artery, the fetal descending thoracic aorta, and one fetal middle cerebral artery were performed in 65 well-controlled diabetic pregnancies in a cross-sectional study at the Harris Birthright Research Centre for Fetal Medicine, London. In 41 cases cordocentesis was also performed for the measurement of umbilical venous blood pH, Po2, and hematocrit.
  
  
  RESULTS
  The mean umbilical venous blood pH was significantly lower and the hematocrit significantly higher than the appropriate normal mean for gestation. However, the Doppler indices of the placental and fetal circulations were essentially normal, except in some of the cases complicated by preeclampsia or intrauterine growth retardation.
  
  
  CONCLUSIONS
  Maternal diabetes mellitus is not associated with abnormalities in Doppler indexes of the placental or fetal circulations.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital School of Medicine, London, England.
authors.forename: D R
authors.initials: DR
authors.lastname: Salvesen
authors.forename: M T
authors.initials: MT
authors.lastname: Higueras
authors.forename: C A
authors.initials: CA
authors.lastname: Mansur
authors.forename: J
authors.initials: J
authors.lastname: Freeman
authors.forename: J M
authors.initials: JM
authors.lastname: Brudenell
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005312:Fetal Blood; D005333:Fetus / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000503:physiopathology*; D011674:Pulse; D014465:Ultrasonics; D014471:Umbilical Veins
chemical_list: D001786:Blood Glucose; D010100:Oxygen