[Preventive effect of an immunomodulator, OM-85 BV, on acute exacerbations of chronic bronchitis in elderly patients. Preliminary results at six months in 291 patients].
Three hundred fifty six patients aged 65 years or more (mean age 81.8 years) who were suffering from chronic bronchitis were included in a double-blind trial against placebo to assess the preventative effect of OM-85 BV against acute exacerbations of chronic bronchitis. OM-85 BV is an immunostimulant composed of lyophilised factions of 8 bacteria which are most frequently encountered during the course of respiratory tract infections. 291 patients completed the study. In the group treated by OM-85 BV, a significant increase in the number of patients with no episode of acute bronchitis was noted (96 versus 71, p = 0.006). There was a 38.8% reduction in the absolute numbers of episodes of acute bronchitis and a 33% reduction in the number of prescriptions for antibiotics, however there was no difference in the number of pneumonias and bronchopneumonias. These results show the protective effect of OM-85 BV against bronchial superinfections in a large population of elderly patients suffering from chronic bronchitis.
Orcel
B
B
Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Delclaux
B
B
Baud
M
M
Derenne
J P
JP
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D001419:Bacteria; D001772:Blood Cell Count; D001784:Blood Gas Analysis; D001991:Bronchitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D002457:Cell Extracts; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D002457:Cell Extracts; D007136:Immunoglobulins; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates