O6-alkyltransferase activity in normal and abnormal gastric mucosa.
The activity of the DNA repair enzyme O6-alkyltransferase has been studied in a series of stomachs with abnormal gastric mucosa and the activities found compared with those in normal stomachs. Enzyme activities found in stomachs with the macroscopic abnormalities of gastric ulcer, duodenal ulcer or gastric cancer were not significantly different from normal. In those stomachs where there was histological evidence of chronic atrophic gastritis or intestinal metaplasia however enzyme activities (mean 398 fmole/mg) were significantly higher than normal (mean activity 228 fmole/mg activity P < 0.001). We speculate that the conditions which stimulate these histological changes also give rise to induction of O6-alkyltransferase.
Dyke
G W
GW
Jack Birch Unit for Environmental Carcinogenesis, Department of Biology, University of York, UK.
Craven
J L
JL
Hall
R
R
Garner
R C
RC
D000328:Adult; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000378:metabolism*; D008875:Middle Aged; D013272:Stomach Diseases / Q000201:enzymology*; D013274:Stomach Neoplasms / Q000201:enzymology
D008780:Methyltransferases