title: A method of dynamic analysis of iodine-123-metaiodobenzylguanidine scintigrams in cardiac mechanical overload hypertrophy and failure.
abstract: Cardiac sympathetic neuronal degeneration accompanies mechanical overload heart failure. We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload. Our aim was to develop a method for the dynamic analysis of 123I-MIBG scintigrams which could yield a quantitative index of myocardial sympathetic neuronal function in this condition. We performed serial 123I-MIBG scintigraphy in 33 volunteers, 10 orthotopic cardiac transplant recipients and 26 patients with chronic mechanical overload of the left ventricle. We constructed a compartmental model in which total heart activity represents the sum of cardiac sympathetic vesicular and cytosolic pools. Patients with antecedent mechanical overload heart failure or myocardial dysfunction had accelerated myocardial egress of tracer that we ascribed to a specific impairment in vesicular storage rather than to a more rapid turnover of an intact vesicular pool.
authors.affiliation: McGill University, Montreal, Quebec, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Rabinovitch
authors.forename: C P
authors.initials: CP
authors.lastname: Rose
authors.forename: A J
authors.initials: AJ
authors.lastname: Schwab
authors.forename: D H
authors.initials: DH
authors.lastname: Fitchett
authors.forename: G N
authors.initials: GN
authors.lastname: Honos
authors.forename: J A
authors.initials: JA
authors.lastname: Stewart
authors.forename: L F
authors.initials: LF
authors.lastname: Chen
authors.forename: E P
authors.initials: EP
authors.lastname: Castilla
authors.forename: A A
authors.initials: AA
authors.lastname: Gomez
authors.forename: M
authors.initials: M
authors.lastname: Abrahamowicz
mesh_terms: D019797:3-Iodobenzylguanidine; D003000:Clonidine / Q000627:therapeutic use; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation; D006333:Heart Failure / Q000000981:diagnostic imaging*; D016027:Heart Transplantation / Q000000981:diagnostic imaging*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging*; D007091:Image Processing, Computer-Assisted; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D013565:Sympatholytics
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013565:Sympatholytics; D019797:3-Iodobenzylguanidine; D003000:Clonidine