Potential of bone marrow biopsy in chronic myeloproliferative disorders (MPD).
The chronic myeloproliferative disorders (MPD) comprise polycythemia vera (PV), idiopathic thrombocythemia (IT), chronic myeloid leukemia (CML) and myelofibrosis/osteomyelosclerosis (MF/OMS). Bone marrow biopsies of 3500 patients with known or suspected MPD were studied, and the clinical and morphologic variables registered were utilized for multivariate data analysis by selected BMD computer programs. The histologic criteria and the histologic subdivisions, as well as the evolution and prognosis of disease are outlined for each of the clinical entities. The results show that a bone marrow biopsy provides independent diagnostic and prognostic data in this group of hematologic malignancies and therefore constitutes an additional parameter in the diagnostic investigation of patients with suspected or established MPD.
Bartl
R
R
Medizinische Klinik III, Klinikum Grosshadern, University of Munich, Germany.
Frisch
B
B
Wilmanns
W
W
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D002455:Cell Division; D002460:Cell Line; D002908:Chronic Disease; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology; D008533:Megakaryocytes / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000473:pathology*; D011087:Polycythemia Vera / Q000473:pathology; D055728:Primary Myelofibrosis / Q000473:pathology; D011379:Prognosis; D013920:Thrombocythemia, Essential / Q000473:pathology