title: Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma.
abstract: Topically applied demecarium bromide (0.125 and 0.25%) and echothiophate iodide (0.125 and 0.25%) solutions were evaluated in Beagles with normotensive eyes and Beagles with inherited glaucoma. In single-dose studies, the effects of intraocular pressure (IOP) and pupil size (PS) were measured in eyes before drug treatment and in drug- and nondrug-treated eyes. Both concentrations of the 2 drugs induced long-term miosis and decrease in IOP in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma. Demecarium bromide (0.125 and 0.5%) decreased IOP for 49 and 55 hours, respectively. Echothiophate iodide (0.125 and 0.5%) reduced IOP for 25 and 53 hours, respectively. The miosis associated with both concentrations of the 2 drugs generally paralleled the decreases in IOP.
authors.affiliation: Gwathmey-Adams Laboratory for Visual Science, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126.
authors.forename: G G
authors.initials: GG
authors.lastname: Gum
authors.forename: K N
authors.initials: KN
authors.lastname: Gelatt
authors.forename: J K
authors.initials: JK
authors.lastname: Gelatt
authors.forename: R
authors.initials: R
authors.lastname: Jones
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004456:Echothiophate Iodide / Q000494:pharmacology; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011680:Pupil / Q000187:drug effects*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D000644:Quaternary Ammonium Compounds; D004456:Echothiophate Iodide; C100193:demecarium