[Multi-institutional feasibility study of SDI test for its application to the adjuvant chemotherapy of gastric cancer].
For the purpose to evaluate the feasibility of SDI test, a drug sensitivity test, against resected gastric cancer a multi-institutional study called as consisted of multiple institute the 16th Specified Study was planned by Japanese Foundation for Multidisciplinary Treatment of Cancer. SDI test was performed individually in 15 institutes in Japan using surgically resected specimens from the patients with gastric cancer. The adjuvant chemotherapy in each case was selected by randomized stratification. The anticancer drugs used were tegafur and one of the following three drug, mitomycin C (MMC), adriamycin (ADM) and cisplatin (CDDP). The drug sensitivity of each tumor was assayed by SDI test. The strict quality control was necessary to unify the method and the technique of this test in 15 institutes. Tumor bearing nude mice were delivered to each institute and the test was performed simultaneously. The data of this test were sent by personal computer to our Department. The clinical feasibility of this test will be evaluated after accumulation of cases for the statistic analysis.
Yamauchi
M
M
Dept. of Surgery, Tokai Chuo Hospital, Kakamigahara, Japan.
Kondo
T
T
D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000494:pharmacology* / Q000627:therapeutic use; D004317:Doxorubicin / Q000494:pharmacology* / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor / Q000592:standards; D005240:Feasibility Studies; D006801:Humans; D016685:Mitomycin / Q000494:pharmacology* / Q000627:therapeutic use; D011182:Postoperative Care; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D016685:Mitomycin; D004317:Doxorubicin; D013385:Succinate Dehydrogenase; D002945:Cisplatin