The ascites in the ovarian hyperstimulation syndrome does not originate from the ovary.
OBJECTIVE
To evaluate the direct ovarian contribution to ascites formation in the ovarian hyperstimulation syndrome (OHSS) in a rabbit model.


METHODS
Prospective experimental study.


METHODS
Research center of a university teaching hospital.


METHODS
New Zealand White rabbits.


METHODS
Both ovaries of the rabbits in the experimental group were enclosed within a pouch developed from the surrounding peritoneum and mesosalpinx by microsurgery. Animals in the control group did not undergo any surgical intervention. Ovarian hyperstimulation was induced by alternate day equine chorionic gonadotropin and intermittent human chorionic gonadotropin (hCG).


METHODS
Degree of ascites formation and the morphological and endocrinologic signs of ovarian hyperstimulation.


RESULTS
The serial plasma estradiol and progesterone levels, ovarian weights, and ascites response were not statistically different between the two groups.


CONCLUSIONS
Isolation of both ovaries from the peritoneal cavity does not prevent ascites formation in the OHSS. Increased transudation across extraovarian serosal surfaces contributes to ascites formation in OHSS.
Yarali
H
H
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
Fleige-Zahradka
B G
BG
Yuen
B H
BH
McComb
P F
PF
D000818:Animals; D001201:Ascites / Q000209:etiology*; D005260:Female; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000503:physiopathology; D010053:Ovary / Q000503:physiopathology*; D011817:Rabbits