HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis.
Two unrelated young males with the unusual simultaneous presence of insulin-dependent diabetes mellitus, ulcerative colitis and primary sclerosing cholangitis are reported. Both patients manifested homozygosity for the DR3-DQw2 (DQB*0201) HLA genotypes. We believe that homozygosity for this genotype may predispose for this type of multi-organ autoimmune disease.
Ivarsson
S A
SA
Department of Paediatrics, University of Lund, Malmö General Hospital, Sweden.
Eriksson
S
S
Kockum
I
I
Lernmark
A
A
Lindgren
S
S
Nilsson
K O
KO
Sundkvist
G
G
Wassmuth
R
R
D000293:Adolescent; D002648:Child; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male
D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D015803:HLA-DR3 Antigen