title: Calbistrins, novel antifungal agents produced by Penicillium restrictum. I. Production, taxonomy of the producing organism and biological activity.
abstract: A novel antibiotic complex, named the calbistrins, has been discovered in the culture broth of a soil fungus. The producing organism, designated AB 1875C-28, was identified as a strain of Penicillium restrictum. Calbistrin A, the most potent of the 4-membered complex, has MICs of 0.78 micrograms/ml against Candida albicans. Only poor activity is observed against non-candida yeasts, filamentous fungi and bacteria.
authors.affiliation: Anti-infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064.
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: J P
authors.initials: JP
authors.lastname: Karwowski
authors.forename: P E
authors.initials: PE
authors.lastname: Humphrey
authors.forename: W L
authors.initials: WL
authors.lastname: Kohl
authors.forename: G J
authors.initials: GJ
authors.lastname: Barlow
authors.forename: S K
authors.initials: SK
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D005285:Fermentation; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D010407:Penicillium / Q000737:chemistry* / Q000145:classification; D011090:Polyenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D011090:Polyenes