Correlation between the lung distribution patterns of Lu-ECAM-1 and melanoma experimental metastases.
Lu-ECAM-1 is a 90-kDa lectin-like, melanoma-cell-binding endothelial-cell adhesion molecule that mediates colonization of the lungs by B16-F10 melanoma cells. The well-known formation of pleural and sub-pleural B16-F10 melanoma colonies is correlated quantitatively with prominent histochemical staining of endothelia of pleural capillaries and sub-pleural venules with anti-Lu-ECAM-1 MAb 6D3. The less frequent endothelial staining of perivenous and peribronchial venules is associated with fewer B16-F10 colonies in these locations, and the occasional segmental staining of pulmonary veins coincides with rare tumor nodules which usually expand in an asymmetric fashion around these veins. Lu-ECAM-1 is also expressed on endothelia of some tumor vessels, indicating that these vessels are recruited from the same host blood vessels that originally caused the arrest of blood-borne B16-F10 melanoma cells. The close association between the lung distribution patterns of Lu-ECAM-1-positive blood vessels and experimental melanoma metastases is further evidence of the importance of endothelial-cell adhesion molecules in the formation of metastases.
Zhu
D
D
Department of Pathology, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853.
Pauli
B U
BU
D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D009362:Neoplasm Metastasis; D014407:Tumor Cells, Cultured
D015815:Cell Adhesion Molecules; C071433:Lu-ECAM-1 protein, Bos taurus