A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.
Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
Feunteun
J
J
Laboratoire d'Oncologie Moléculaire, URA 1158 CNRS, Institut Gustave Roussy, Villejuif, France.
Narod
S A
SA
Lynch
H T
HT
Watson
P
P
Conway
T
T
Lynch
J
J
Parboosingh
J
J
O'Connell
P
P
White
R
R
Lenoir
G M
GM
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002170:Canada; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D005192:Family Health; D005260:Female; D015870:Gene Expression; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D014481:United States
D005819:Genetic Markers