title: Comparative toxicity and pathology associated with administration of recombinant HuIL-1 alpha to animals.
authors.affiliation: Department of Toxicology and Pathology, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
authors.forename: T D
authors.initials: TD
authors.lastname: Anderson
authors.forename: R
authors.initials: R
authors.lastname: Arceco
authors.forename: T J
authors.initials: TJ
authors.lastname: Hayes
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002522:Chlorocebus aethiops; D004285:Dogs; D005123:Eye / Q000187:drug effects / Q000473:pathology; D005260:Female; D005334:Fever / Q000139:chemically induced; D005342:Fibrinolysis / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology / Q000633:toxicity*; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009205:Myocarditis / Q000139:chemically induced / Q000473:pathology; D011993:Recombinant Fusion Proteins / Q000494:pharmacology / Q000633:toxicity*; D013045:Species Specificity; D013163:Splenomegaly / Q000139:chemically induced / Q000473:pathology; D014781:Viscera / Q000187:drug effects / Q000473:pathology; D015431:Weight Loss / Q000187:drug effects
chemical_list: D007375:Interleukin-1; D011993:Recombinant Fusion Proteins