title: Does TGF-beta protect articular cartilage in vivo?
abstract: Repeated intraarticular injections of transforming growth factor beta cause stimulation of articular cartilage proteoglycan synthesis, influx of inflammatory cells, fibrosis and osteophyte formation. When injected together with interleukin-1, TGF-beta enhances IL-1 induced cell-attraction in a synergistic way, while it counteracts IL-1 induced suppression of cartilage PG synthesis.
authors.affiliation: Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
authors.forename: H M
authors.initials: HM
authors.lastname: van Beuningen
authors.forename: P M
authors.initials: PM
authors.lastname: van der Kraan
authors.forename: O J
authors.initials: OJ
authors.lastname: Arntz
authors.forename: W B
authors.initials: WB
authors.lastname: van den Berg
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism / Q000473:pathology; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007267:Injections; D007375:Interleukin-1 / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D011509:Proteoglycans / Q000096:biosynthesis; D013431:Sulfates / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D007375:Interleukin-1; D011509:Proteoglycans; D013431:Sulfates; D016212:Transforming Growth Factor beta