title: Renal allograft artery stenosis: results of medical treatment and intervention. A retrospective analysis.
abstract: In a retrospective analysis of 1165 renal transplantations in our center, 65 cases of renal allograft artery stenosis were diagnosed angiographically (prevalence 5.5%). Hypertension was present in all cases; a bruit over the allograft and an increase in serum creatinine level were additional reasons for angiography. Shortly after diagnosis of the stenosis, two patients died and two others lost their grafts due to thrombosis. In 24 patients the decision was made not to correct the stenosis. One of these grafts was lost because the stenosis could not be corrected. Medical management of hypertension in these patients resulted in a decrease in diastolic blood pressure from 109 +/- 22 to 96 +/- 12 mm Hg (P < 0.01) 3 months after diagnosis with the use of almost twice as many antihypertensive drugs as at the time of diagnosis (P < 0.01). The stenosis was corrected if the angiography showed it to be so severe that it jeopardized renal allograft function or caused uncontrollable hypertension. Only three of nine percutaneous transluminal angioplasty (PTA) procedures resulted in a definitive correction of the stenosis. Surgical intervention was performed in 30 patients, including two patients whose PTAs had proved unsuccessful. Surgery led to graft loss due to thrombosis in 6 of 30 operations (20%), whereas restenosis occurred twice (7%). In three other cases (10%), the correction was not successful due to local anatomical variations or concomitant rejection.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Clinical Vascular Laboratory, University Hospital St. Radboud, Nijmegen, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Merkus
authors.forename: F T
authors.initials: FT
authors.lastname: Huysmans
authors.forename: A J
authors.initials: AJ
authors.lastname: Hoitsma
authors.forename: F G
authors.initials: FG
authors.lastname: Buskens
authors.forename: S H
authors.initials: SH
authors.lastname: Skotnicki
authors.forename: R A
authors.initials: RA
authors.lastname: Koene
mesh_terms: D000800:Angioplasty, Balloon; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents