Bleeding varices due to portal hypertension in sarcoidosis. Favorable effect of propranolol and prednisone.
A 58-year-old white man had bleeding varices in the gastric fundus due to portal hypertension attributable to histologically proven hepatic sarcoid involvement with a giant splenomegaly and with an angiographically demonstrated significant flow toward the liver. Treatment with corticosteroids and beta-blockade (30 mg propranolol daily) resulted in no rebleeding for over one year follow-up.
Melissant
C F
CF
Department of Internal Medicine, Municipal Hospital Leyenburg, The Hague, The Netherlands.
Smith
S J
SJ
Kazzaz
B A
BA
Demedts
M
M
D004359:Drug Therapy, Combination; D004932:Esophageal and Gastric Varices / Q000188:drug therapy* / Q000209:etiology; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy* / Q000209:etiology; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage*; D012507:Sarcoidosis / Q000150:complications*
D011433:Propranolol; D011241:Prednisone