Effect of antihypertensive drugs on ethanol induced gastric lesions: is there a correlation with mucosal blood flow?
We studied the effect of five antihypertensive drugs on ethanol-induced gastric haemorrhagic lesions in rats. While hydralazine aggravates these lesions, nifedipine and propranolol have a protective action. On the other hand, enalapril and prazosin have no effect. Thus the effects of antihypertensive drugs on ethanol-induced lesions do not always correlate with their reported actions on gastric mucosal blood flow.
Rataboli
P V
PV
Department of Pharmacology, Goa Medical College, Tiswadi.
Diniz D'Souza
R S
RS
Dhume
V G
VG
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D000431:Ethanol / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D006830:Hydralazine / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013272:Stomach Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D014665:Vasodilator Agents / Q000494:pharmacology
D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D006830:Hydralazine; D000431:Ethanol; D011433:Propranolol