Hypercalcaemia and elevated levels of parathyroid hormone-related protein in cutaneous squamous/basal cell carcinoma.
A patient with mixed squamous/basal cell carcinoma of the skin presented with hypercalcaemia and elevated serum levels of parathyroid hormone-related protein (PTH-rP). The tumour was resected, PTH-rP levels declined and the patient became normocalcaemic. This is the first case to associate squamous cell carcinoma of the skin with hypercalcaemia and significant levels of PTH-rP.
Marino
M T
MT
Department of Pharmacology, Walter Reed Army Institute of Research, Washington, DC.
Asp
A A
AA
Budayer
A A
AA
Marsden
J S
JS
Strewler
G J
GJ
D000368:Aged; D002280:Basal Cell Carcinoma / Q000097:blood* / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D009363:Neoplasm Proteins / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000097:blood* / Q000150:complications
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins