title: Associations of serum lipids with metabolic control and diet in young subjects with insulin-dependent diabetes mellitus in Finland.
abstract: Association of serum lipids with metabolic control and diet were studied in 72 young subjects with insulin-dependent diabetes mellitus (IDDM). Data on food consumption were collected by the 48-h recall method. Glycosylated haemoglobin (Hb) A1 was used as a measure of metabolic control. There were no differences between males and females in the mean values for serum total cholesterol (TC, 4.5 and 4.9 mmol/l, respectively), low density lipoprotein cholesterol (LDL-C, 2.7 and 3.0 mmol/l), high density lipoprotein cholesterol (HDL-C, 1.3 and 1.4 mmol/l), or serum triglycerides (TG, 1.1 and 1.0 mmol/l). Diabetic subjects who were in better metabolic control (HbA1 < 10.5%), when compared with those in poorer control (HbA1 > or = 10.5%) had lower TC and TG values and a higher HDL-C/TC ratio. HbA1 level and intake of saturated fatty acids were positively associated with serum TC and LDL-C values and explained 14% and 15% of the variation in TC and LDL-C, respectively. HbA1 level and insulin dose per kg of body weight were positively associated with serum TG values and explained 30% of the variation in TG. Serum TC and LDL-C levels of young subjects with IDDM could be lowered by improving their metabolic control and decreasing their saturated fatty acid intake.
authors.affiliation: Department of Applied Chemistry and Microbiology, Aurora Hospital, Helsinki, Finland.
authors.forename: S M
authors.initials: SM
authors.lastname: Virtanen
authors.forename: L
authors.initials: L
authors.lastname: Räsänen
authors.forename: M
authors.initials: M
authors.lastname: Virtanen
authors.forename: H
authors.initials: H
authors.lastname: Sippola
authors.forename: A
authors.initials: A
authors.lastname: Rilva
authors.forename: E A
authors.initials: EA
authors.lastname: Kaprio
authors.forename: J
authors.initials: J
authors.lastname: Mäenpää
authors.forename: H K
authors.initials: HK
authors.lastname: Akerblom
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000178:diet therapy / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage; D004734:Energy Metabolism; D005260:Female; D005387:Finland; D006442:Glycated Hemoglobin / Q000032:analysis*; D006776:Hospitals, Pediatric; D006785:Hospitals, University; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D009749:Nutrition Surveys; D010044:Outpatient Clinics, Hospital; D014280:Triglycerides / Q000097:blood*
chemical_list: D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D006442:Glycated Hemoglobin; D007328:Insulin; D014280:Triglycerides