title: Lesion-induced re-expression of neonatal recognition molecules in adult rat cerebellum.
abstract: It has been previously shown that sectioning of parallel fibers in the cerebellar molecular layer of adult rats gave rise to rapid reinnervation of the target cells, i.e., Purkinje cells. This paper reports that such a reinnervation is accompanied by reexpression (partial and total) of two developmentally regulated complementary molecules. These are an endogenous mannose-binding lectin, called R1, which reappears at the surface of the dendrites of Purkinje cells, and an endogenous glycoprotein ligand of R1, the 31 kDa glycoprotein, which seems to be neosynthetized and transported to the surface of parallel fibers. In this system, embryonic N-CAM is not reexpressed in neurons but reappears in reactive astrocytes in the vicinity of the lesion. The reexpression of recognition molecules (lectin and glycoprotein ligand) involved in normal synaptogenesis, may constitute the molecular basis for repair of nervous circuits in the adult as well.
authors.affiliation: Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, CNRS UPR A 0416, Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Lehmann
authors.forename: S
authors.initials: S
authors.lastname: Kuchler
authors.forename: S
authors.initials: S
authors.lastname: Gobaille
authors.forename: P
authors.initials: P
authors.lastname: Marschal
authors.forename: A
authors.initials: A
authors.lastname: Badache
authors.forename: G
authors.initials: G
authors.lastname: Vincendon
authors.forename: J P
authors.initials: JP
authors.lastname: Zanetta
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002531:Cerebellum / Q000293:injuries* / Q000378:metabolism; D006023:Glycoproteins / Q000032:analysis / Q000096:biosynthesis*; D007150:Immunohistochemistry; D037102:Lectins / Q000032:analysis / Q000096:biosynthesis*; D008970:Molecular Weight; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology*
chemical_list: D006023:Glycoproteins; D037102:Lectins