Lack of effects of 5-HT3 antagonists on normal and morphine-attenuated sexual behaviours in female and male rats.
Although 5-HT1 and 5-HT2 receptor activity is known to influence copulation, the effects of 5-HT3 receptor-selective drugs on sexual activity have yet to be systematically studied. The following experiments investigated the effects of the 5-HT3-selective antagonists MDL 72222, ondansetron and ICS 205-930 on female sexual behaviour; male rats were studied using ondansetron and granisetron. These compounds influenced neither male nor female copulatory behaviours, suggesting that 5-HT3 receptors contribute little to the modulation of sexual activity. 5-HT3 receptor antagonists block certain opioid-induced behaviours and opioids selectively inhibit sexual behaviours; therefore, the ability of ondansetron and ICS 205-930 to modify morphine-attenuated copulatory activity was also tested. While morphine inhibited copulation, 5-HT3 antagonists failed to reverse the effects.
Tanco
S A
SA
Department of Psychology, University of British Columbia, Vancouver, Canada.
Watson
N V
NV
Gorzalka
B B
BB
D000818:Animals; D005260:Female; D008141:Lordosis; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D009020:Morphine