title: Fast neutron radiotherapy for locally advanced prostate cancer. Final report of Radiation Therapy Oncology Group randomized clinical trial.
abstract: Between June 1977 and April 1983 the Radiation Therapy Oncology Group (RTOG) sponsored a Phase III randomized trial investigating the use of fast neutron radiotherapy for patients with locally advanced (Stages C and D1) adenocarcinoma of the prostate gland. Patients were randomized to receive either conventional photon radiation or fast neutron radiation used in a mixed-beam (neutron/photon) treatment schedule. A total of 91 analyzable patients were entered into the study, and the two patient groups were balanced with respect to the major prognostic variables. Actuarial curves are presented for local/regional control and "overall" survival. Ten-year results for clinically assessed local control are 70% for the mixed-beam group versus 58% for the photon group (p = 0.03) and for survival are 46% for the mixed-beam group versus 29% for the photon group (p = 0.04). This study suggests that a regional method of treatment can influence both local tumor control and survival in patients with locally advanced adenocarcinoma of the prostate gland.
authors.affiliation: Department of Radiation Oncology, University of Washington Medical Center, Seattle 98195.
authors.forename: G E
authors.initials: GE
authors.lastname: Laramore
authors.forename: J M
authors.initials: JM
authors.lastname: Krall
authors.forename: F J
authors.initials: FJ
authors.lastname: Thomas
authors.forename: K J
authors.initials: KJ
authors.lastname: Russell
authors.forename: M H
authors.initials: MH
authors.lastname: Maor
authors.forename: F R
authors.initials: FR
authors.lastname: Hendrickson
authors.forename: K L
authors.initials: KL
authors.lastname: Martz
authors.forename: T W
authors.initials: TW
authors.lastname: Griffin
authors.forename: L W
authors.initials: LW
authors.lastname: Davis
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000556:secondary*; D005214:Fast Neutrons; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000379:methods; D016019:Survival Analysis