Humoral and cell-mediated sensitivity to cartilage constituents in mice with antigen-induced arthritis.
Serum antibodies against native collagen type II and cartilage proteoglycans as well as proliferative responses of spleen lymphocytes to these antigens were evidenced during the progression of antigen-induced arthritis in mice. Because there were some correlations to the severity of arthritis, it is suggested that autoimmunity to cartilage constituents play a role for the persistence of the joint inflammation and cartilage destruction in this experimental model of chronic arthritis.
Bräuer
R
R
Institute of Pathology, Friedrich Schiller University, Jena, Germany.
Thoss
K
K
Henzgen
S
S
D000818:Animals; D000917:Antibody Formation; D001169:Arthritis, Experimental / Q000276:immunology* / Q000473:pathology; D015551:Autoimmunity / Q000276:immunology; D002358:Cartilage, Articular / Q000276:immunology* / Q000473:pathology; D003094:Collagen / Q000276:immunology; D005260:Female; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D011509:Proteoglycans / Q000276:immunology; D051381:Rats
D011509:Proteoglycans; D003094:Collagen