Presence of N-methyldopamine in parkinsonian and normal human brains.
N-Methyldopamine (epinine) has been identified for the first time in parkinsonian and normal human brains by gas chromatography-mass spectrometry. N-Methylsalsolinol and N-methylnorsalsolinol, which are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces parkinsonism in humans, may be synthesized from N-methyldopamine by the Pictet-Spengler condensation reaction as an alternative metabolic pathway.
Kajita
M
M
Department of Pediatrics, Nagoya University School of Medicine, Japan.
Niwa
T
T
Takeda
N
N
Yoshizumi
H
H
Tatematsu
A
A
Watanabe
K
K
Nagatsu
T
T
D001921:Brain / Q000378:metabolism*; D003846:Deoxyepinephrine / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism*; D012490:Salsoline Alkaloids / Q000378:metabolism; D044005:Tetrahydroisoquinolines
D007546:Isoquinolines; D012490:Salsoline Alkaloids; D044005:Tetrahydroisoquinolines; C069194:2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; C032837:salsoline; D003846:Deoxyepinephrine