Differential effects of nicotine but not cathinone on motor activity of P and NP rats.
The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in spontaneous locomotor activity (SMA) to nicotine, NP animals showed no change (0.4 mg/kg) or depression of activity (0.8 mg/kg). However, following cathinone administration both P and NP rats exhibited an increase in SMA. The above results are discussed in light of the genotypic variations between P/NP rats and the potential mediation of differential neurotransmitter effects in the two lines.
Gordon
T L
TL
Department of Pharmacology, College of Medicine, Northeastern Ohio Universities, Rootstown 44272.
Meehan
S M
SM
Schechter
M D
MD
D000428:Alcohol Drinking / Q000523:psychology*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects; D005838:Genotype; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats
D000470:Alkaloids; D011619:Psychotropic Drugs; C023665:cathinone; D009538:Nicotine; D003913:Dextroamphetamine