Peripheral bombesin induces c-fos protein in the rat brain.
Bombesin injected intraperitoneally induces c-fos protein-like immunoreactivity in the medial nucleus tractus solitarius and the parvocellular part of the paraventricular nucleus of the hypothalamus in the rat brain. C-fos expression induced by bombesin is less densely represented compared with CCK. Capsaicin pretreatment did not influence c-fos-immunoreactivity induced by bombesin and significantly reduced that induced by CCK.
Bonaz
B
B
CURE/Digestive Disease Center, Veterans Administration, Wadsworth Medical Center, Los Angeles, CA 90073.
De Giorgio
R
R
Taché
Y
Y
D000818:Animals; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007150:Immunohistochemistry; D007267:Injections; D007274:Injections, Intraperitoneal; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects; D010286:Paraventricular Hypothalamic Nucleus; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013268:Stimulation, Chemical
D016760:Proto-Oncogene Proteins c-fos; D002766:Cholecystokinin; D001839:Bombesin; D002211:Capsaicin