Pharmacological manipulation of acute cyclosporin ischemic renal injury with trimetazidine.
Cyclosporin has had a major impact on organ transplantation, but associated nephrotoxicity is a significant problem. Renal hypothermia, a known anti-ischemic maneuver, limits cyclosporin-ischemic renal failure. Pharmacological manipulation with an anti-ischemic agent, such as trimetazidine, may prevent cyclosporin nephrotoxicity. We tested this hypothesis in a canine single kidney model of cyclosporin-enhanced ischemic renal failure. Trimetazidine treatment was associated with significantly better biochemical and histological markers of renal function and structure. Trimetazidine may have a role to play in protecting against cyclosporin nephrotoxicity in clinical renal transplantation.
Creagh
T
T
Department of Surgery, Beaumont Hospital, Dublin, Ireland.
Lanigan
D
D
Dolan
J
J
Tormey
W
W
Walshe
J J
JJ
Bouchier-Hayes
D
D
D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects*; D004285:Dogs; D007511:Ischemia / Q000139:chemically induced* / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000517:prevention & control*; D014292:Trimetazidine / Q000627:therapeutic use*
D016572:Cyclosporine; D014292:Trimetazidine