Linkage of a major breast cancer gene to chromosome 17q12-21: results from 15 Edinburgh families.
DNA from members of 15 pedigrees each containing between three and eight cases of breast cancer have been collected from southeastern Scotland. Polymorphic markers on chromosome 17q were screened to locate a putative breast cancer gene by using DNA from relevant individuals within these families. Pairwise LOD scores were calculated for markers D17S74, NM23, D17S588, and D17S579. The maximal summated LOD for the 15 families was 5.44 at theta = .034, when D17S588 (42D6) was used. In these breast cancer families, a subset which did not give evidence for linkage to this region could be identified.
Cohen
B B
BB
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
Porter
D E
DE
Wallace
M R
MR
Carothers
A
A
Steel
C M
CM
D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D002461:Cell Line, Transformed; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis; D004276:DNA, Satellite / Q000032:analysis; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D012606:Scotland
D004273:DNA, Neoplasm; D004276:DNA, Satellite; D005819:Genetic Markers