title: Oxygenation of head and neck tumors.
abstract: BACKGROUND
  Tumor hypoxia could play a role in the response to radiation therapy. Few data are available on oxygen tension (pO2) measurements in head and neck tumors.
  
  
  METHODS
  The KIMOC-6650 Histograph (Eppendorf, Hamburg, Germany) was used to measure the oxygenation status of normal tissues and head and neck tumors in 20 patients.
  
  
  RESULTS
  The median pO2 for normal tissues was 43 mmHg with very low pO2 values (2.0 mmHg or less) recorded in two patients. Low median pO2 levels (10 mmHg or less) were recorded in 2 of 5 primary tumors and in 11 of 15 metastatic lymphadenopathies, with very low values in 11 nodes. The median pO2 in tumors was lower than that of normal tissues in 12 of 15 patients with comparative measurements. Oxygen tension was recorded in three nodes after an evaluation of tissue density (by computed tomographic scanner); in two nodes, the mean and median pO2 values were lower in the hypodense areas than in isodense areas. The data for N2 and N3 nodes showed significantly more values below 2.0 mmHg as nodal size increased (P < 10(-4), by chi-square test). No systematic decrease in pO2 was recorded from the periphery to the center of the tumors.
  
  
  CONCLUSIONS
  Very low pO2 values, corresponding to radiobiologic hypoxia, were found in most of these tumors. The prognostic value of these pO2 measurements in regard to treatment response remains to be demonstrated.
authors.affiliation: Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.
authors.forename: E
authors.initials: E
authors.lastname: Lartigau
authors.forename: A M
authors.initials: AM
authors.lastname: Le Ridant
authors.forename: P
authors.initials: P
authors.lastname: Lambin
authors.forename: P
authors.initials: P
authors.lastname: Weeger
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: R
authors.initials: R
authors.lastname: Sigal
authors.forename: A
authors.initials: A
authors.lastname: Lusinchi
authors.forename: B
authors.initials: B
authors.lastname: Luboinski
authors.forename: F
authors.initials: F
authors.lastname: Eschwege
authors.forename: M
authors.initials: M
authors.lastname: Guichard
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D015687:Cell Hypoxia / Q000502:physiology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D014057:Tomography, X-Ray Computed
chemical_list: D010100:Oxygen