Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. II. Structure determination.
The structure of sandramycin, a novel antitumor antibiotic, was established by spectroscopic analysis and chiral chromatography of its acid hydrolysate. It was determined to be a cyclic decadepsipeptide with a two-fold axis of symmetry and 3-hydroxyquinaldic acid as an appended chromophore.
Matson
J A
JA
Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492.
Colson
K L
KL
Belofsky
G N
GN
Bleiberg
B B
BB
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009618:Nocardiaceae / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D010456:Peptides, Cyclic; C063090:sandramycin