Activity-dependent regulation of conductances in model neurons.
Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.
LeMasson
G
G
Department of Biology, Brandeis University, Waltham, MA 02254.
Marder
E
E
Abbott
L F
LF
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D004553:Electric Conductivity; D004558:Electric Stimulation; D005246:Feedback; D008954:Models, Biological; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology; D015290:Second Messenger Systems; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D011188:Potassium; D002118:Calcium