Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children.
Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.
Cryz
S J
SJ
Swiss Serum and Vaccine Institute, Berne.
Vanprapar
N
N
Thisyakorn
U
U
Olanratmanee
T
T
Losonsky
G
G
Levine
M M
MM
Chearskul
S
S
D000367:Age Factors; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D013785:Thailand; D014435:Typhoid Fever / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000276:immunology* / Q000592:standards; D014611:Vaccination
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; D014436:Typhoid-Paratyphoid Vaccines