Bone mineralization in the first year of life in infants fed human milk, cow-milk formula, or soy-based formula.
OBJECTIVE
To test the hypotheses that (1) bone mineral content (BMC) is similar in infants fed soy-based formula (SBF) and human milk (HM) and higher in infants fed cow milk-based formula (CBF) and (2) serum 1,25-dihydroxyvitamin D, an index of mineral sufficiency, is similar in infants fed formula and infants fed HM.


METHODS
Randomized, prospective study of formula-fed group only.


METHODS
Recruitment was in a normal newborn nursery.


METHODS
72 infants: 10 given HM, 20 given CBF (Similac), 21 given SBF (Isomil), and 21 given SBF (Prosobee).


METHODS
BMC and 1,25-dihydroxyvitamin D levels at baseline (days 2 through 7 of life) and at 8, 16, 26, and 52 weeks of age. The BMC was similar in all groups at all times; serum 1,25-dihydroxyvitamin D levels were similar in all groups, except that they were elevated at 8, 16, and 26 weeks in those fed Prosobee.


CONCLUSIONS
(1) BMC is similar in SBF-, CBF-, and HM-fed infants and (2) compensatory elevation of serum 1,25-dihydroxyvitamin D concentrations may occur in SBF-fed infants.
Mimouni
F
F
Perinatal Research Institute, University of Cincinnati, Ohio.
Campaigne
B
B
Neylan
M
M
Tsang
R C
RC
D000818:Animals; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002113:Calcification, Physiologic / Q000502:physiology*; D002117:Calcitriol / Q000097:blood; D002508:Cephalometry; D005500:Follow-Up Studies; D006128:Growth / Q000502:physiology; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D008892:Milk; D008895:Milk, Human; D010758:Phosphorus / Q000097:blood; D011446:Prospective Studies; D016037:Single-Blind Method; D014807:Vitamin D / Q000097:blood*
D014807:Vitamin D; D010758:Phosphorus; D002117:Calcitriol