[Thromboxane A2 receptor; structure, function and tissue distribution].
Thromboxane A2 is an unstable, yet quite potent metabolite of arachidonic acid. Analysis of cDNAs of human and mouse thromboxane A2 receptors revealed important information in regard to the function of thromboxane A2 and its regulation. Examination of amino acid sequences of the receptors provides some information how the ligand binds to the receptor and how desensitization of the receptor occurs. mRNA of the thromboxane A2 receptor is abundantly expressed in the thymus, lung and spleen, and suggests novel function of thromboxane A2. Further progress on understanding of thromboxane A2 and development of effective drugs may be made on the basis of these findings.
Namba
T
T
Department of Pharmacology, Faculty of Medicine, Kyoto University.
Narumiya
S
S
D000595:Amino Acid Sequence; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism; D017482:Receptors, Thromboxane / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D013930:Thromboxane-A Synthase / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism
D012333:RNA, Messenger; D017482:Receptors, Thromboxane; D013930:Thromboxane-A Synthase