title: Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25-->p24.
abstract: Thyroid peroxidase (TPO), the enzyme responsible for thyroid hormone synthesis, is a key autoantigen in autoimmune thyroid disease. Based on the results of a study using both isotopic and nonisotopic in situ hybridization, we assign the gene coding for human TPO to chromosome region 2p25-->p24.
authors.affiliation: Department of Medicine, King's College School of Medicine and Dentistry, London, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Barnett
authors.forename: T A
authors.initials: TA
authors.lastname: Jones
authors.forename: A M
authors.initials: AM
authors.lastname: McGregor
authors.forename: J P
authors.initials: JP
authors.lastname: Banga
authors.forename: D
authors.initials: D
authors.lastname: Sheer
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D015342:DNA Probes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007453:Iodide Peroxidase / Q000235:genetics*
chemical_list: D015342:DNA Probes; D007453:Iodide Peroxidase