Endothelin and the respiratory system.
Pharmacological research involving the endothelin peptides has emphasized their activities in vascular systems, from both physiological and pathophysiological perspectives. However, the endothelins are known also to be synthesized and released from respiratory epithelial cells and to have potent effects in nonvascular components of the respiratory tract. Douglas Hay, Peter Henry and Roy Goldie summarize present understanding of the pharmacology of the endothelins in the respiratory system and assess the potential pathophysiological role in asthma.
Hay
D W
DW
Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
Henry
P J
PJ
Goldie
R G
RG
D001249:Asthma / Q000378:metabolism*; D001345:Autoradiography; D001665:Binding Sites; D016084:Bronchoconstriction / Q000187:drug effects; D016232:Endothelins / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D017466:Receptors, Endothelin / Q000378:metabolism*; D012137:Respiratory System / Q000378:metabolism*; D012140:Respiratory Tract Diseases / Q000378:metabolism*
D016232:Endothelins; D017466:Receptors, Endothelin