title: Decreased high-density lipoprotein cholesterol and increased low-density cholesterol levels in patients with colorectal adenomas.
abstract: OBJECTIVE
  To study the relation between serum lipoprotein levels and the frequency of colorectal adenomas, the benign precursors of colorectal cancer.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  University hospital in Germany.
  
  
  METHODS
  The study included 822 of 1124 consecutive patients who underwent colonoscopy at our institution (302 patients were excluded because of malignant disease, chronic inflammatory bowel disease, familial polyposis, partial colectomy, or other chronic diseases). Of the 822 study patients, 194 had colorectal adenoma.
  
  
  METHODS
  Serum cholesterol fractions (high-density lipoprotein [HDL], low-density lipoprotein [LDL], and very low-density lipoprotein [VLDL]) and presence or absence of adenomas; univariate and logistic regression analyses were carried out to evaluate the association between serum HDL, LDL, and VLDL cholesterol levels and the frequency of colorectal adenoma.
  
  
  RESULTS
  Univariate analysis of the total patient group showed that the HDL cholesterol level was inversely related to the frequency of colorectal adenoma (odds ratio, 0.36; 95% Cl, 0.21 to 0.62) and that LDL and VLDL cholesterol levels were positively associated with adenoma frequency (odds ratio, 2.31 [Cl, 1.36 to 3.92] and 1.72 [Cl, 1.03 to 2.86], respectively). Univariate analysis of the subgroup of 89 patients with high-risk adenomas showed an inverse association between such adenomas and HDL cholesterol (odds ratio, 0.37; Cl, 0.18 to 0.76). A logistic regression analysis that included age and body mass index showed an association between lipoprotein levels and the presence of adenomas. The relative strength (in descending order) of these associations was as follows: HDL, LDL, VLDL, and total serum cholesterol. A logistic regression analysis of patients with high-risk adenoma showed a significant association between such adenomas and the HDL cholesterol level.
  
  
  CONCLUSIONS
  Patients with colorectal adenomas have lower HDL cholesterol levels and higher LDL and VLDL cholesterol levels; these lipoproteins may have prognostic significance for the development of colorectal adenomas.
authors.affiliation: Medical Department II, Klinikum Grosshadern, University of Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Bayerdörffer
authors.forename: G A
authors.initials: GA
authors.lastname: Mannes
authors.forename: W O
authors.initials: WO
authors.lastname: Richter
authors.forename: T
authors.initials: T
authors.lastname: Ochsenkühn
authors.forename: G
authors.initials: G
authors.lastname: Seeholzer
authors.forename: W
authors.initials: W
authors.lastname: Köpcke
authors.forename: B
authors.initials: B
authors.lastname: Wiebecke
authors.forename: G
authors.initials: G
authors.lastname: Paumgartner
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood*; D015243:Cholesterol, VLDL / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012044:Regression Analysis
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL