title: [Dramatic remission of a multiple metastasized melanoma caused by chemo-immunotherapy].
abstract: A 47 year old woman underwent excision of a malignant melanoma on the right shoulder. Nine years later she was attacked by intense pain in the back. Computed tomography, bone scans and immunohistochemical study of a liver biopsy specimen revealed metastases from the malignant melanoma in the liver, spleen and skeleton. Her Karnovsky score was 50%. Chemoimmunotherapy given for five cycles consisting of dacarbazine (800 mg/m2 body surface area every 4 weeks) together with ambulatory cytokine therapy (interferon alpha-2b subcutaneously, 5 million I.U. on days 1 and 3 to 7 in the first week, days 1, 3 and 5 in the second and third weeks and interleukin 2.9 million I.U. on days 1 to 5 in the second and third weeks; no treatment was given in the fourth week) raised the Karnovsky score to 90% and abolished the pain. Lactate dehydrogenase activity, originally 3372 U/l, dropped to normal. Computed tomography demonstrated definite shrinkage of the liver metastases and some regression of the splenic and bony deposits. This improvement has now been maintained for a total of eight cycles of therapy.
authors.affiliation: Hautklinik, Christian-Albrechts-Universität Kiel.
authors.forename: A
authors.initials: A
authors.lastname: Hauschild
authors.forename: G
authors.initials: G
authors.lastname: Osterkamp
authors.forename: M
authors.initials: M
authors.lastname: Clausen
authors.forename: E
authors.initials: E
authors.lastname: Christophers
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D007378:Interleukins / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction; D012878:Skin Neoplasms / Q000473:pathology*; D013160:Splenic Neoplasms / Q000188:drug therapy / Q000556:secondary
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007378:Interleukins; D011994:Recombinant Proteins; D003606:Dacarbazine