title: Hypercholesterolaemia in briards in the United Kingdom.
abstract: Elevated fasting plasma cholesterol concentrations were identified in clinically healthy briards. Biochemical investigations revealed no other major abnormalities. Plasma lipoprotein electrophoresis demonstrated a marked increase in the intensity of the alpha 2 band (compared with control dogs) which was reduced by dextran sulphate-magnesium chloride or sodium phosphotungstate-magnesium chloride precipitation of apo B and apo E containing lipoproteins in the plasma. The study has identified a hyperlipidaemia in briards characterised by increased cholesterol but normal triglyceride concentrations. The absence of obvious metabolic changes associated with secondary hypercholesterolaemia, suggests the breed may have a primary abnormality in cholesterol metabolism. The increased density of the precipitable lipoprotein which migrates to the alpha 2 band suggests that the hypercholesterolaemia may be due to an abnormal accumulation of high density lipoprotein (HDL) possibly HDLc. The possibility that abnormality in lipid metabolism might play a role in the development of retinal pigment epithelial dystrophy in briards is currently being investigated.
authors.affiliation: Royal Veterinary College, University of London, Hatfield, Hertfordshire.
authors.forename: P
authors.initials: P
authors.lastname: Watson
authors.forename: K W
authors.initials: KW
authors.lastname: Simpson
authors.forename: P G
authors.initials: PG
authors.lastname: Bedford
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D006937:Hypercholesterolemia / Q000097:blood / Q000662:veterinary*; D008055:Lipids / Q000097:blood*; D008297:Male; D006113:United Kingdom
chemical_list: D008055:Lipids