title: Tc-99m isonitrile uptake in a brain metastatic lesion. Comparison with Tc-99m DTPA using planar and SPECT imaging.
abstract: Tc-99m isonitrile uptake in a metastatic brain tumor is demonstrated using planar and SPECT imaging. Comparison with Tc-99m DTPA shows a different distribution pattern and uptake intensity, suggesting a different mechanism for both tracers. It is possible that Tc-99m CPI could reflect metabolic activity of the tumor cells and might be useful to evaluate the grade of malignancy as well as the recurrence of brain tumors.
authors.affiliation: Nuclear Medicine Center, Clinical Hospital, Montevideo, Uruguay.
authors.forename: F
authors.initials: F
authors.lastname: Mut
authors.forename: A
authors.initials: A
authors.lastname: Bianco
authors.forename: M
authors.initials: M
authors.lastname: Nuñez
authors.forename: G
authors.initials: G
authors.lastname: De Palma
authors.forename: E
authors.initials: E
authors.lastname: Touya
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; C051216:technetium Tc 99m carbomethoxyisopropylisonitrile; D016284:Technetium Tc 99m Pentetate