title: L-gulono-gamma-lactone oxidase is the enzyme responsible for the production of methylguanidine in the rat liver.
abstract: A methylguanidine-synthesizing enzyme localized in rat liver microsomes produces methylguanidine via the intermediates creatone A and creatone B from the substrate, creatol, a substance produced from creatinine mainly by reaction with hydroxyl radicals. This enzyme has been identified as L-gulono-gamma-lactone oxidase (EC 1.1.3.8). However, no corresponding activity was found in extracts from human livers.
authors.affiliation: Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fujitsuka
authors.forename: T
authors.initials: T
authors.lastname: Yokozawa
authors.forename: H
authors.initials: H
authors.lastname: Oura
authors.forename: T
authors.initials: T
authors.lastname: Akao
authors.forename: K
authors.initials: K
authors.lastname: Kobashi
authors.forename: K
authors.initials: K
authors.lastname: Ienaga
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D050544:L-Gulonolactone Oxidase; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008760:Methylguanidine / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013347:Subcellular Fractions / Q000201:enzymology; D013401:Sugar Alcohol Dehydrogenases / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D008760:Methylguanidine; D013401:Sugar Alcohol Dehydrogenases; D050544:L-Gulonolactone Oxidase