title: In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteria.
abstract: The in vitro activity of the fluoroquinolone CP-99,219 against gram-positive bacteria was compared with those of five other antimicrobial agents. Against ciprofloxacin-susceptible staphylococci and against streptococci, MICs were < or = 0.12 and < or = 0.5 microgram/ml, respectively. CP-99,219 was also more active than ciprofloxacin against ciprofloxacin-resistant staphylococci, most enterococci, Leuconostoc spp., and lactobacilli.
authors.affiliation: Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
authors.forename: K
authors.initials: K
authors.lastname: Klimm
authors.forename: C T
authors.initials: CT
authors.lastname: Eliopoulos
authors.forename: M J
authors.initials: MJ
authors.lastname: Ferraro
authors.forename: R C
authors.initials: RC
authors.lastname: Moellering
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin