Direct effect of deferoxamine on hemoglobin synthesis in patients on hemodialysis treated with recombinant human erythropoietin.
We have studied the response of hemoglobin (Hb), hematocrit, reticulocytes, mean corpuscular volume, ferritin, serum iron, total iron-binding capacity (TIBC) and the transferrin saturation index in 9 patients on chronic hemodialysis (HD) with minimal aluminum overload who were treated with recombinant human erythropoietin (rHuEPO) when a single dose of deferoxamine (DFO; 40 mg/kg b.w.) was administered. Analytical determinations were performed basally and 48 h, 7 days and 14 days after a DFO test. Hb increased from a basal value of 10 +/- 0.28 to 10.7 +/- 0.33 (p < 0.05), 10.4 +/- 0.33 (p < 0.05) and 10.1 +/- 0.31 g/dl (NS), respectively, and similar increases were seen with the hematocrit. Serum iron increased from 52 +/- 7.62 to 89.2 +/- 14.48 (p < 0.01), 94 +/- 18.73 (p < 0.01) and 85 +/- 14.01 micrograms/dl (p < 0.01), respectively. TIBC and ferritin did not change but the transferrin saturation index increased significantly. DFO produces an immediate improvement of the anemia in HD patients treated with rHuEPO and who have minimal aluminium accumulation: it should be related to an increased iron availability to erythroid precursors either releasing stored iron or decreasing aluminum-bound transferrin.
Romero
R
R
Servicio de Nefrología, Hospital Xeral de Galicia, Santiago de Compostela, España.
Novoa
D
D
Otero
S
S
Alonso
M C
MC
Alonso
R
R
Arcocha
V
V
Arza
D
D
Lens
X M
XM
Sanchez-Guisande
D
D
D000368:Aged; D000535:Aluminum / Q000097:blood / Q000378:metabolism; D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D003676:Deferoxamine / Q000494:pharmacology*; D004921:Erythropoietin / Q000494:pharmacology*; D005293:Ferritins / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000096:biosynthesis*; D006801:Humans; D007501:Iron / Q000097:blood; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology; D006435:Renal Dialysis; D014168:Transferrin / Q000378:metabolism
D006454:Hemoglobins; D011994:Recombinant Proteins; D014168:Transferrin; D004921:Erythropoietin; D005293:Ferritins; D000535:Aluminum; D007501:Iron; D003676:Deferoxamine