title: Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.
abstract: In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.
authors.affiliation: Department of Pathology, University of Cambridge, England.
authors.forename: S A
authors.initials: SA
authors.lastname: Smith
authors.forename: D F
authors.initials: DF
authors.lastname: Easton
authors.forename: D
authors.initials: D
authors.lastname: Ford
authors.forename: J
authors.initials: J
authors.lastname: Peto
authors.forename: K
authors.initials: K
authors.lastname: Anderson
authors.forename: D
authors.initials: D
authors.lastname: Averill
authors.forename: M
authors.initials: M
authors.lastname: Stratton
authors.forename: M
authors.initials: M
authors.lastname: Ponder
authors.forename: C
authors.initials: C
authors.lastname: Pye
authors.forename: B A
authors.initials: BA
authors.lastname: Ponder
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis; D004276:DNA, Satellite / Q000032:analysis; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D011519:Proto-Oncogenes; D011995:Recombination, Genetic
chemical_list: D004273:DNA, Neoplasm; D004276:DNA, Satellite; D005819:Genetic Markers