title: An elementary method for implementing complex biokinetic models.
abstract: Recent efforts to incorporate greater anatomical and physiological realism into biokinetic models have resulted in many cases in mathematically complex formulations that limit routine application of the models. This paper describes an elementary, computer-efficient technique for implementing complex compartmental models, with attention focused primarily on biokinetic models involving time-dependent transfer rates and recycling. The technique applies, in particular, to the physiologically based, age-specific biokinetic models recommended in Publication No. 56 of the International Commission on Radiological Protection, Age-Dependent Doses to Members of the Public from Intake of Radionuclides.
authors.affiliation: Health and Safety Research Division, Oak Ridge National Laboratory, TN 37831.
authors.forename: R W
authors.initials: RW
authors.lastname: Leggett
authors.forename: K F
authors.initials: KF
authors.lastname: Eckerman
authors.forename: L R
authors.initials: LR
authors.lastname: Williams
mesh_terms: D000367:Age Factors; D000576:Americium / Q000493:pharmacokinetics; D006801:Humans; D007223:Infant; D008954:Models, Biological; D011829:Radiation Dosage; D011868:Radioisotopes / Q000493:pharmacokinetics*; D012984:Software
chemical_list: D011868:Radioisotopes; D000576:Americium