title: Recent advances in understanding mechanically induced bone remodeling and their relevance to orthodontic theory and practice.
abstract: This review highlights recent developments in bone cell biology, evaluates previous research, and offers future direction toward improving our understanding of events that mediate orthodontic tooth movement. The in vivo and in vitro models that have been developed to examine the responses of connective tissues and how they have contributed to our understanding of the mechanisms involved in mechanically induced bone remodeling are discussed in detail. Osteoblasts are now recognized as the cells that control both the resorptive and the formative phases of the remodeling cycle, and receptor studies have shown them to be the target cells for resorptive agents in bone. The osteoblast is perceived as a pivotal cell, controlling many of the responses of bone to stimulation with hormones and mechanical forces. It is apparent that not all the cellular responses induced by mechanically deformed tissues can be explained by the current paradigm emphasizing the importance of prostaglandin production and cAMP elevation; the mobilization of membrane phospholipids giving rise to inositol phosphates offers an alternative second messenger pathway. It is also argued from circumstantial evidence that changes in cell shape produce a range of effects mediated by membrane integral proteins (integrins) and the cytoskeleton, which may be important in transducing mechanical deformation into a meaningful biologic response.
authors.affiliation: Cell and Molecular Biology Department, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.
authors.forename: J R
authors.initials: JR
authors.lastname: Sandy
authors.forename: R W
authors.initials: RW
authors.lastname: Farndale
authors.forename: M C
authors.initials: MC
authors.lastname: Meikle
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption; D016207:Cytokines / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D015290:Second Messenger Systems
chemical_list: D016207:Cytokines; D003598:Cytoskeletal Proteins; D011453:Prostaglandins