title: Gangliosides facilitate the recovery of behavioral response mediated by dopaminergic sites following their irreversible blockade.
abstract: The effect of acute and chronic exogenous ganglioside (G) administration on the functional recovery of dopaminergic receptors following their blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was investigated by means of apomorphine (APO)-induced stereotyped behavior. Animals previously treated with EEDQ exhibited a lack of behavioral response to APO 6 or 24 h later. A progressive behavioral recovery was already evident at day 3 and reached control values at day 7. G pretreatment accelerated the behavioral recovery after EEDQ administration, because a higher behavioral response to APO in these animals as compared with rats treated with EEDQ alone at the same time was observed. These findings indicate that G accelerates the functional recovery of dopaminergic sites following their irreversible blockade.
authors.affiliation: Departamento de Farmacología, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba, Argentina.
authors.forename: E A
authors.initials: EA
authors.lastname: Keller
authors.forename: V A
authors.initials: VA
authors.lastname: Molina
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D018492:Dopamine Antagonists; D005732:Gangliosides / Q000494:pharmacology*; D008297:Male; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology
chemical_list: D018492:Dopamine Antagonists; D005732:Gangliosides; D011804:Quinolines; D011954:Receptors, Dopamine; C000470:EEDQ; D001058:Apomorphine