Gastrointestinal effects of single and repeated doses of ferrous sulphate in rats.
The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faecal Cl. perfringens toxin after treatment with a high dose of FeSO4. The chronic experiment at lower doses showed no relevant histological damage, some iron deposition and strong alterations in faecal flora. A strong impact of oral FeSO4 on gastrointestinal environment was demonstrated.
Benoni
G
G
Institute of Pharmacology, University of Verona, Policlinico Borgo Roma, Italy.
Cuzzolin
L
L
Zambreri
D
D
Donini
M
M
Del Soldato
P
P
Caramazza
I
I
D000818:Animals; D004064:Digestive System / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D004386:Duodenum / Q000187:drug effects; D005243:Feces / Q000382:microbiology; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects; D013997:Time Factors
D005296:Ferrous Compounds; C020748:ferrous sulfate