The 5' sequence of human factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes.
The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.
Citarella
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Dipartimento di Biopatologia Umana, Università di Roma La Sapienza, Italy.
Misiti
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Felici
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Aiuti
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La Porta
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Fantoni
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D001483:Base Sequence; D001665:Binding Sites; D004967:Estrogens / Q000502:physiology*; D005174:Factor XII / Q000235:genetics*; D005809:Genes, Regulator; D015698:Genomic Library; D006801:Humans; D008099:Liver / Q000502:physiology*; D008969:Molecular Sequence Data; D012045:Regulatory Sequences, Nucleic Acid; D015183:Restriction Mapping; D016385:TATA Box; D014158:Transcription, Genetic
D004967:Estrogens; D005174:Factor XII