title: Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis.
abstract: The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.
authors.affiliation: Depto Anatomía Patológica, Hospital Príncipes de España, Universidad de Barcelona.
authors.forename: I
authors.initials: I
authors.lastname: Ferrer
authors.forename: T
authors.initials: T
authors.lastname: Tuñón
authors.forename: M T
authors.initials: MT
authors.lastname: Serrano
authors.forename: R
authors.initials: R
authors.lastname: Casas
authors.forename: S
authors.initials: S
authors.lastname: Alcántara
authors.forename: M J
authors.initials: MJ
authors.lastname: Zújar
authors.forename: R M
authors.initials: RM
authors.lastname: Rivera
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D001253:Astrocytes / Q000473:pathology; D001284:Atrophy; D064026:Calbindins; D003704:Dementia / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D005911:Gliosis / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D009410:Nerve Degeneration / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000473:pathology; D009474:Neurons / Q000473:pathology; D010320:Parvalbumins / Q000032:analysis*; D064030:S100 Calcium Binding Protein G / Q000032:analysis*
chemical_list: D064026:Calbindins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G