title: Follicular development and ovarian hormone secretion following passive immunization of ewes against inhibin or oestradiol.
abstract: Immunization against inhibin or oestradiol causes an increase in the peripheral plasma concentration of FSH. In this study we have investigated the effect of this post-immunization rise in FSH concentration on follicular development by means of real-time ultrasonography, in ewes in which an ovary and its vascular pedicle had been autotransplanted to a site in the neck. Groups of ewes on day 10 of the luteal phase of the oestrous cycle were injected with a single 10 ml i.v. bolus of plasma from normal ewes (control; n = 4), antiserum to the 1-26 peptide fragment of the N-terminus of the alpha chain of porcine inhibin (n = 5) or antiserum to oestradiol-17 beta (n = 4). The plasma concentration of FSH was unaffected by treatment in the control group but showed a significant (P < 0.001) rise following treatment in both immunized groups (inhibin-immunized 175% over 19h; oestradiol-immunized 138% over 22 h as a per cent of the original value). This rise in FSH concentration was accompanied by a significant (P < 0.001) rise in the total number of follicles > 2.0 mm per ovary in both immunized groups (inhibin-immunized 5.5 +/- 1.0 to 13.6 +/- 1.4; oestradiol-immunized 4.6 +/- 0.5 to 11.5 +/- 1.0).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Obstetrics and Gynaecology, University of Edinburgh, U.K.
authors.forename: G E
authors.initials: GE
authors.lastname: Mann
authors.forename: B K
authors.initials: BK
authors.lastname: Campbell
authors.forename: A S
authors.initials: AS
authors.lastname: McNeilly
authors.forename: D T
authors.initials: DT
authors.lastname: Baird
mesh_terms: D000818:Animals; D004958:Estradiol / Q000276:immunology / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D007116:Immunization, Passive; D007265:Inhibins / Q000276:immunology / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000502:physiology*; D010053:Ovary / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D012756:Sheep; D013997:Time Factors
chemical_list: D012739:Gonadal Steroid Hormones; D011374:Progesterone; D004958:Estradiol; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone