Myocardial accumulation of iodinated beta-methyl-branched fatty acid analog, [125I](p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP), and correlation to ATP concentration--II. Studies in salt-induced hypertensive rats.
This study investigates the possible relationship between myocardial [125I]BMIPP accumulation and ATP concentration, in the salt-induced hypertensive Dahl-strain rats. [125I]BMIPP accumulation in the myocardium was inversely related to the degree of hypertension. On the other hand, ATP levels increased in the myocardium of rats with higher blood pressure showing an inverse relationship with BMIPP accumulation. Further studies are required for elucidating these possible inter-related phenomena.
Fujibayashi
Y
Y
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Som
P
P
Yonekura
Y
Y
Knapp
F F
FF
Tamaki
N
N
Yamamoto
K
K
Konishi
J
J
Yokoyama
A
A
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D002851:Chromatography, High Pressure Liquid; D005227:Fatty Acids; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D007462:Iodobenzenes / Q000378:metabolism* / Q000493:pharmacokinetics; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D012965:Sodium Chloride / Q000009:adverse effects; D014018:Tissue Distribution
D005227:Fatty Acids; D007462:Iodobenzenes; C049338:iodofiltic acid; D012965:Sodium Chloride; D000255:Adenosine Triphosphate