Synthesis and antihypertensive activities of new 1,4-dihydropyridine derivatives containing a nitrooxy moiety at the 3-ester position.
The synthesis of a new series of dihydropyridines containing a nitrooxy moiety at the 3-ester position is described. The antihypertensive activity of the compounds was examined and compared with that of nifedipine; some of them were relatively potent. The structure-activity relationship is also discussed.
Ogawa
T
T
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Nakazato
A
A
Tsuchida
K
K
Hatayama
K
K
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D005260:Female; D008297:Male
D000959:Antihypertensive Agents; D004095:Dihydropyridines