In vitro construction of cells-containing implants for articular cartilage regeneration.
Regeneration of destroyed articular cartilage can be induced by transplantation of cartilage cells into the defects. The best results are obtained by the use of either fetal allogeneic cells or autogenic ones. Induction of chondrogenesis in residual mesenchymal cells is optimal for obtaining large amounts of autogenic chondrocytes. Further modification of the technique is needed to reconstruct large defects. The cells are grown on biodegradable scaffolds and are later implanted into joint defects.
Robinson
D
D
Tel Aviv University, Israel.
Efrat
M
M
Mendes
D G
DG
Halperin
N
N
Nevo
Z
Z
D000818:Animals; D002358:Cartilage, Articular / Q000502:physiology / Q000637:transplantation*; D002448:Cell Adhesion; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D003584:Cytological Techniques; D006025:Glycosaminoglycans / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology; D010641:Phenotype; D011817:Rabbits; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology
D006025:Glycosaminoglycans