Chemonucleolysis. Personal history, trials, and tribulations.
This article is a review of the controversial history of chemonucleolysis. The review begins in 1963 and concludes with recent findings that demonstrated that in properly selected patients, chemonucleolysis can be as effective and safe as laminectomy.
Smith
L
L
Department of Orthopaedic Surgery, Northwestern University Medical School, Lake Wales, Florida.
D000818:Animals; D002917:Chymopapain / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007404:Intervertebral Disc Chemolysis / Q000009:adverse effects; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000628:therapy*; D011859:Radiography
D002917:Chymopapain