[Four cases of CD7-positive acute myeloid leukemia].
This report describes 4 cases of T-cell-associated CD7-positive acute myeloid leukemia (AML). Myelo-peroxidase staining of blasts was negative in 2 cases but became positive during their courses. In all cases, the myeloid determinants CD13 and/or CD33 were associated with CD7 expression. Other B-lymphoid (CD10, CD19) or T-lymphoid (CD2) markers were negative. In three cases, dual fluorescence analyses showed co-expression of CD7 and CD13 (CD33). Clinically, compared with CD7+AML, these CD7+AML patients presented higher leukocyte and blast counts in peripheral blood. All patients achieved complete remission with chemotherapeutic regimens for AML, but 3 relapsed within a short time. Systemic lymphadenopathy was found in 2 cases, and interestingly, the surface markers of the lymph-node in one case were CD7+CD33-. These cases of CD7+AML may represent a distinct subgroup that arises from particular, less different myeloid precursors, and may have poor prognosis.
Tomiyama
J
J
Department of Internal Medicine, Tokyo Metropolitan Bokuto Hospital.
Mitsuhashi
S
S
Kudo
H
H
Adachi
Y
Y
D000208:Acute Disease; D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis; D006801:Humans; D007951:Leukemia, Myeloid / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D015703:Antigens, CD; D006681:HLA-D Antigens