[Mefloquine and sulfadoxine/pyrimethamine overdose in malaria tropica].
A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.
Burgmann
H
H
Abteilung für Infektionen und Chemotherapie, Innere Medizin I, Wien.
Winkler
S
S
Uhl
F
F
Feucht
M
M
Hellgren
U
U
Bergqvist
Y
Y
Feistauer
S
S
Breyer
S
S
Graninger
W
W
D000328:Adult; D003975:Diazepam / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000008:administration & dosage; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D015767:Mefloquine / Q000008:administration & dosage / Q000506:poisoning*; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000506:poisoning*; D013413:Sulfadoxine / Q000008:administration & dosage / Q000506:poisoning*; D013881:Thioridazine / Q000008:administration & dosage
D013413:Sulfadoxine; D006220:Haloperidol; D013881:Thioridazine; D003975:Diazepam; D015767:Mefloquine; D011739:Pyrimethamine