title: Immunopathology of alkaline phosphatase isozymes in seminoma.
abstract: An immunohistopathological study using monoclonal antibodies for alkaline phosphatases demonstrated placental alkaline phosphatase (PLAP)-like substance in the tumor cells of 11 pure seminomas, 1 seminoma with embryonal carcinoma and 1 seminoma metastasis. Liver alkaline phosphatase (LAP) could also be demonstrated in all seminomas but a third intestinal alkaline phosphatase (IAP) was not demonstrable in any tumor. The PLAP-like substance and LAP had considerable enzyme activities. This provides two tumor markers of seminomas detectable in histopathological specimens.
authors.affiliation: Department of Urology, Kanazawa University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Uchibayashi
authors.forename: K
authors.initials: K
authors.lastname: Koshida
authors.forename: K
authors.initials: K
authors.lastname: Hirano
authors.forename: H
authors.initials: H
authors.lastname: Hisazumi
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis*; D004407:Dysgerminoma / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D007422:Intestines / Q000201:enzymology; D007527:Isoenzymes / Q000032:analysis*; D008099:Liver / Q000201:enzymology; D008297:Male; D010920:Placenta / Q000201:enzymology; D013736:Testicular Neoplasms / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D000469:Alkaline Phosphatase