title: Anterior chamber reaction after mitomycin and 5-fluorouracil trabeculectomy: a comparative study.
abstract: We measured aqueous flare in 16 glaucomatous eyes after trabeculectomy in which 5-fluorouracil (5-FU) or mitomycin C (MMC) had been used as an adjunctive therapy. The eyes were divided into a 5-FU and an MMC group, matched for factors that might influence the postoperative inflammatory response to intraocular surgery. Seven eyes of seven patients received subconjunctival injections of 5-FU (50 mg in 2 weeks) and nine eyes of nine patients were given 0.2 mg/0.5 mL MMC intraoperatively. The aqueous flare converted to an albumin concentration (mg/dL) was significantly higher in the 5-FU group than in the MMC group (359.6 +/- 113.8 mg/dL and 143.2 +/- 46.7 mg/dL, respectively; Mann-Whitney U test, P < .05) on the second postoperative day. Intraoperative MMC appears to be no more harmful to the blood-aqueous barrier than 5-FU.
authors.affiliation: Dept of Ophthalmology, Gifu University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawase
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Jikihara
authors.forename: Y
authors.initials: Y
authors.lastname: Kitazawa
mesh_terms: D000867:Anterior Chamber / Q000187:drug effects*; D001082:Aqueous Humor / Q000378:metabolism*; D001693:Biological Transport, Active; D001769:Blood / Q000378:metabolism; D017024:Chemotherapy, Adjuvant; D005136:Eye Proteins / Q000378:metabolism; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D014130:Trabeculectomy
chemical_list: D005136:Eye Proteins; D016685:Mitomycin; D005472:Fluorouracil