[Antiarrhythmia active amidinohydrazone substituted benzophenones. 5. The stability of (Z)-2-amino-5-chlorobenzophenone amidinohydrazone acetate in solution].
The aqueous solution of the title compound can be used for injection for one year if it is stored at room temperature and under light protection. Under these conditions 8% of the E-isomer are produced. The reaction is reversible at day light. Red coloured products of decomposition are formed by long lasting influence of light. At higher temperatures or at sterilisation several products of decomposition are formed which structure is elucidated. For these decomposition a scheme is proposed.
Schleuder
M
M
Fachbereich Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.
Richter
P H
PH
Keckeis
A
A
Jira
T
T
D000889:Anti-Arrhythmia Agents / Q000737:chemistry*; D001577:Benzophenones / Q000737:chemistry*; D004355:Drug Stability; D006835:Hydrazones / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013816:Thermodynamics
D000889:Anti-Arrhythmia Agents; D001577:Benzophenones; D006835:Hydrazones; D012996:Solutions; C080444:(Z)-2-amino-5-chlorobenzophenonamidinohydrazone acetate