Prospective evaluation of effects of broad-spectrum antibiotics on gastrointestinal yeast colonization of humans.
This study evaluated the effects of broad-spectrum antibiotics on the gastrointestinal (G.I.) yeast flora of humans and correlated the findings with those obtained from a mouse model of G.I. colonization by Candida albicans. We prospectively studied 46 adult cancer patients who received one of five broad-spectrum antibiotics (ceftriaxone, ceftazidime, ticarcillin-clavulanic acid, imipenem-cilastatin, and aztreonam) as therapy for infections. Quantitative examination of yeast colonization of stools was conducted at the baseline, at the end of antibiotic treatment, and 1 week after discontinuation of therapy. Antibiotics with anaerobic activity (ticarcillin-clavulanic acid) or high G.I. concentrations (ceftriaxone) caused a higher and more sustained increase in G.I. colonization by yeasts than did antibiotics with poor anaerobic activity (ceftazidime and aztreonam) or a low G.I. concentration (imipenem-cilastatin). These results were similar to those obtained with a mouse model of G.I. colonization by C. albicans that involved the same antibiotics. Hence, the mouse model may be useful for evaluation of yeast colonization of the human G.I. tract.
Samonis
G
G
Department of Medical Oncology, University of Crete, Heraklion, Greece.
Gikas
A
A
Anaissie
E J
EJ
Vrenzos
G
G
Maraki
S
S
Tselentis
Y
Y
Bodey
G P
GP
D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D004064:Digestive System / Q000187:drug effects / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D051379:Mice; D011446:Prospective Studies
D000900:Anti-Bacterial Agents