title: Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. II. Structure determination.
abstract: The structure of sandramycin, a novel antitumor antibiotic, was established by spectroscopic analysis and chiral chromatography of its acid hydrolysate. It was determined to be a cyclic decadepsipeptide with a two-fold axis of symmetry and 3-hydroxyquinaldic acid as an appended chromophore.
authors.affiliation: Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492.
authors.forename: J A
authors.initials: JA
authors.lastname: Matson
authors.forename: K L
authors.initials: KL
authors.lastname: Colson
authors.forename: G N
authors.initials: GN
authors.lastname: Belofsky
authors.forename: B B
authors.initials: BB
authors.lastname: Bleiberg
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009618:Nocardiaceae / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship
chemical_list: D000903:Antibiotics, Antineoplastic; D010456:Peptides, Cyclic; C063090:sandramycin