Uridine uptake pattern in the cerebral cortex of grivet monkey.
Assuming that uridine uptake is correlated to RNA synthesis, and thereby to nerve cell function, the distribution of 5-[H3]-uridine-labelled nerve cell nuclei in the cerebral cortex of three hemispheres from two grivet monkeys was examined by microautoradiography. The labelling pattern for 50 cells in layers 2-6 of 10 cortical locations were different in many locations, but in each location they were generally similar. The precentral areas had relatively high labelling, while the motor cortex relatively low, paralleling the bloodflow in these regions. The labelling of layer 4 and 6 was lower than in the other layers of cortex. These measurements provide basic information about the pattern of uridine labelling on the cellular level in primate cortex from animals moving freely in the cage.
Pakkenberg
H
H
Neurological Research Laboratory, Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism* / Q000648:ultrastructure; D002522:Chlorocebus aethiops; D003593:Cytoplasm / Q000378:metabolism; D008297:Male; D009415:Nerve Net / Q000378:metabolism; D014018:Tissue Distribution; D014529:Uridine / Q000493:pharmacokinetics*
D014529:Uridine