Rapamycin treatment prevents and/or erases sensitization and abrogates accelerated rejection of vascularized organ allografts.
Schmidbauer
G
G
Harvard Medical School, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
Hancock
W W
WW
Wasowska
B A
BA
Sablinski
T
T
Kupiec-Weglinski
J W
JW
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D005434:Flow Cytometry; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D016027:Heart Transplantation / Q000276:immunology*; D007114:Immunization; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007518:Isoantibodies / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D011090:Polyenes / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D020123:Sirolimus; D016038:Skin Transplantation / Q000276:immunology*; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D007518:Isoantibodies; D011090:Polyenes; D020123:Sirolimus