Synergistic effect of cholera toxin with cyclosporine and azathioprine on survival of rat renal allografts.
A combination of 10 mg/kg/d of AZA and 0.1 mg/kg/d of CT significantly prolonged graft survival (P < .05) over 10 mg/kg/d of AZA alone. A combination of 2.5 mg/kg/d of CyA and 0.1 mg/kg of CT given only once significantly (P < .05) prolonged graft survival over 2.5 mg/kg/d of CyA alone.
Asano
T
T
Department of Urology, National Defense Medical College, Saitama, Japan.
Murai
M
M
Nakamura
H
H
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D002772:Cholera Toxin / Q000494:pharmacology*; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D002772:Cholera Toxin; D001379:Azathioprine