Myoglobin protects against endothelial cell membrane damage associated with hydrogen peroxide or xanthine/xanthine oxidase.
Oxymyoglobin at 'physiological' concentrations of 20-100 micromolar protected cultured endothelial cells from damage by xanthine/xanthine oxidase or by hydrogen peroxide. Metmyoglobin also provided a degree of protection, but apomyoglobin was ineffective. Protection was enhanced in the presence of ascorbate (0.01-1 mM). Myoglobin may have a physiological role in the protection of muscular tissue from ischaemia/reperfusion-induced damage.
Yang
W
W
Department of Cardiology, University of Leicester, UK.
de Bono
D
D
D000225:Adenine / Q000378:metabolism; D000818:Animals; D001011:Aorta; D001205:Ascorbic Acid / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008786:Metmyoglobin / Q000378:metabolism / Q000494:pharmacology; D009211:Myoglobin / Q000378:metabolism / Q000494:pharmacology*; D015427:Reperfusion Injury / Q000517:prevention & control; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism / Q000494:pharmacology*; D014970:Xanthines / Q000378:metabolism / Q000494:pharmacology*
D009211:Myoglobin; D014970:Xanthines; C017595:oxymyoglobin; D008786:Metmyoglobin; D019820:Xanthine; D006861:Hydrogen Peroxide; D014969:Xanthine Oxidase; D000225:Adenine; D001205:Ascorbic Acid