Cellular localisation of taurine in the organ of Corti.
The cellular localisation of taurine in the organ of Corti has been established using a monoclonal antibody and confocal fluorescence microscopy. The bulk of the taurine was found in the outer hair cells with very little present in the inner hair cells and supporting structures. The outer hair cells which probably function as an amplification/attenuation gain system, control inner hair cell output to the brain. Taurine is tentatively postulated as being related to calcium fluxes involved in outer hair cell response to sound or olivocochlear bundle stimulation. Other possibilities are also discussed.
Harding
N J
NJ
Department of Pharmacology, Medical School, University of Birmingham, UK.
Davies
W E
WE
D000161:Acoustic Stimulation; D000818:Animals; D000911:Antibodies, Monoclonal; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D009925:Organ of Corti / Q000737:chemistry* / Q000166:cytology; D013654:Taurine / Q000032:analysis*
D000911:Antibodies, Monoclonal; D013654:Taurine