Role of leuprolide acetate depot in hysteroscopic surgery: a controlled study.
OBJECTIVE
To evaluate leuprolide acetate (LA) depot (Enantone Depot, Takeda, Italy) when administered preoperatively in hysteroscopic surgery.


METHODS
Prospective, comparative study.


METHODS
University Clinic of Obstetrics and Gynecology.


METHODS
One hundred ninety-three patients (114 pretreated with LA depot and 79 controls) who underwent hysteroscopic surgery for uterine septa (group A), submucous fibroids (group B), and abnormal uterine bleeding (group C).


RESULTS
In groups B and C there was a significant reduction in the operating time, bleeding during the operation, and the amount of distention medium required after LA depot administration, but no significant differences in surgical feasibility or efficacy were found in group A patients after treatment.


CONCLUSIONS
Preoperative treatment with LA depot is effective in making hysteroscopic surgery easier.
Perino
A
A
Cattedra di Fisiopatologia della Riproduzione Umana, University of Palermo, Italy.
Chianchiano
N
N
Petronio
M
M
Cittadini
E
E
D000328:Adult; D003692:Delayed-Action Preparations; D004717:Endometrium / Q000601:surgery; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009215:Myometrium / Q000601:surgery; D011446:Prospective Studies; D014592:Uterine Hemorrhage / Q000601:surgery; D014594:Uterine Neoplasms / Q000601:surgery; D014599:Uterus / Q000601:surgery*
D003692:Delayed-Action Preparations; D016729:Leuprolide