D21S210: a highly polymorphic (GT)n marker closely linked to the beta-amyloid protein precursor (APP) gene.
We describe a highly polymorphic (GT)n repeat with 14 alleles that is closely linked to the amyloid precursor protein (APP) gene on human chromosome 21. This marker, D21S210, will be useful for studies of linkage of disorders such as Alzheimer disease to the APP gene.
Warren
A C
AC
Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
McInnis
M G
MG
Kalaitsidaki
M
M
Cox
T K
TK
Blaschak
J
J
Chakravarti
A
A
Antonarakis
S E
SE
D000483:Alleles; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D001483:Base Sequence; D002891:Chromosomes, Human, Pair 21; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics*
D016564:Amyloid beta-Protein Precursor