Measurement of anaphylatoxin activity during surgery.
We studied whether or not anaphylatoxins (ATs) are related to stress-related surgery by examining AT measurement in 51 patients undergoing operation. C3a plasma levels in patients who underwent the Caldwell-Luc operation increased from a pre-surgery concentration of 129 +/- 19 (mean +/- SD) ng/ml to 293 +/- 91 ng/ml during surgery under local anesthesia. However, pre- and post-surgery values were almost the same. No significant change occurred in the C5a plasma concentration at any time in patients undergoing the Caldwell-Luc operation, tonsillectomy or partial glossectomy. The mechanism underlying elevation in C3a during surgery is discussed.
Harada
T
T
Department of Otolaryngology, Osaka University Medical School, Japan.
Sakagami
M
M
Sano
M
M
Matsunaga
T
T
D000328:Adult; D000706:Anaphylatoxins / Q000032:analysis*; D000768:Anesthesia, General; D000772:Anesthesia, Local; D002097:C-Reactive Protein / Q000032:analysis; D015926:Complement C3a / Q000032:analysis; D015936:Complement C5a / Q000032:analysis; D005260:Female; D005927:Glossectomy / Q000379:methods; D006801:Humans; D008297:Male; D008437:Maxilla / Q000601:surgery; D008875:Middle Aged; D010027:Osteotomy / Q000379:methods; D013312:Stress, Physiological / Q000378:metabolism*; D013514:Surgical Procedures, Operative; D013997:Time Factors; D014068:Tonsillectomy
D000706:Anaphylatoxins; D015926:Complement C3a; D015936:Complement C5a; D002097:C-Reactive Protein