NCAM of the mammalian lens.
NCAM is present in the plasma membranes of human and rat lens epithelial cells and superficial fiber cells. The predominant isoform in epithelial cells is NCAM 140, while NCAM 120 appears only in the superficial fiber cells. The immunofluorescence patterns are consistent with a decreasing concentration of NCAM associated with fiber cell differentiation.
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Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201.
Alcala
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Maisel
H
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D000818:Animals; D000911:Antibodies, Monoclonal; D002417:Cattle; D015816:Cell Adhesion Molecules, Neuronal / Q000032:analysis*; D002462:Cell Membrane / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D004848:Epithelium / Q000737:chemistry; D005455:Fluorescent Antibody Technique; D006801:Humans; D015151:Immunoblotting; D007908:Lens, Crystalline / Q000737:chemistry*; D051381:Rats; D012160:Retina / Q000737:chemistry
D000911:Antibodies, Monoclonal; D015816:Cell Adhesion Molecules, Neuronal