Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy.
BACKGROUND
Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient.


METHODS
The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline.


RESULTS
Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group.


CONCLUSIONS
This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers.
Bansal
N K
NK
Department of Dermatology, STD, and Leprosy, RNT Medical College, Rajasthan, India.
Mukul
D000287:Administration, Topical; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007918:Leprosy / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage*; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage*; D014456:Ulcer / Q000628:therapy
D012965:Sodium Chloride; D010672:Phenytoin