Ondansetron plus dexamethasone in the control of high dose cisplatin-induced emesis.
Twenty-two patients who underwent chemotherapy with cisplatin (CDDP) at doses > 100 mg/m2 also received antiemetic treatment comprised of the combination of ondansetron plus dexamethasone. The results obtained have shown a good activity from this combination with these high doses of CDDP, with a response of 81.8% (complete+major protection). There were also three therapeutic failures in patients with a few negative prognostic characteristics. It is our intention to use a benzodiazepine and adequate psychological support in an attempt to increase the response percentages in these kinds of patients.
Maisano
R
R
Oncology Clinic, Università di Messina, Italy.
Toscano
G
G
Adamo
V
V
Altavilla
G
G
Caristi
N
N
Chiofalo
G
G
Gnani
A
A
Scimone
A
A
D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy; D017294:Ondansetron / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D017294:Ondansetron; D003907:Dexamethasone; D002945:Cisplatin