title: Effects of carbohydrate intake on the blood ethanol level and alcoholic fatty liver damage in rats.
abstract: Effects of carbohydrate (CHO) intake on the blood ethyl alcohol (ethanol) level were studied in rats with a surgically placed gastric cannula. A basal diet (protein, 2.07; fat, 1.98; CHO, 5.76 g/day), a high-CHO diet (CHO, 4.39 g/day) + ethanol, a medium-CHO diet (CHO, 2.69 g/day) + ethanol or a low-CHO diet (CHO, 0.98 g/day) + ethanol was infused into the stomach for 4 weeks starting from the 2nd postoperative week. The basal diet and the test diets were isocaloric, and the ethanol (2.80 g/day) in the test diets accounted for 39% of the total calories. The liquid diets (50 kcal in 50 ml) were infused over 16 h from 16.00 to 08.00 h each day. The low-CHO diet group had significantly higher blood ethanol levels than the high-CHO diet group 4, 8 and 16 h after the start of infusion. These groups could be ranked by liver triglyceride content at autopsy as follows: low-CHO > medium-CHO > high-CHO > or = basal. Consistent with the triglyceride content, histological changes of the liver could be ranked by the degree of fatty changes in the same order: low-CHO > medium-CHO > high-CHO > basal. Thus, for a given amount of ethanol consumption, lower CHO intake was associated with higher blood ethanol levels and with more severe fatty changes of the liver.
authors.affiliation: Department of Environmental Health, Medical University of Yamanashi, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yonekura
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: A
authors.initials: A
authors.lastname: Sato
mesh_terms: D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000032:analysis; D004040:Dietary Carbohydrates; D000431:Ethanol / Q000097:blood*; D005235:Fatty Liver, Alcoholic / Q000473:pathology / Q000503:physiopathology*; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008297:Male; D009929:Organ Size; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014280:Triglycerides / Q000032:analysis
chemical_list: D004040:Dietary Carbohydrates; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol