Respiratory load compensation. I. Role of the cerebrum.
This study examines the extent to which the cerebrum and other suprapontine structures modulate the respiratory response to added mechanical resistive loads to breathing. Nine adult cats were anesthetized with thiopental sodium, tracheotomized, and instrumented with diaphragm electromyographic (EMGdi) recording electrodes. Two levels of resistive loads and tracheal occlusion were applied at the onset of inspiration in random order before and after decerebration. The integrated signal of the EMGdi (integral of EMGdi) was used to detect changes in respiratory timing and as an index of respiratory motor drive. The results showed that, compared with intact cats, decerebration did not significantly change baseline values for peak integral of EMGdi, respiratory timing, systemic blood pressure, or arterial blood gases. Although the percent changes in the peak integral of EMGdi elicited by the added loads were still significantly greater than those elicited by unloaded control breaths after decerebration, the magnitude of the responses was significantly attenuated at all load levels compared with the intact preparation. It is concluded that the cerebrum and/or other suprapontine structures provide information that is facilitatory to the respiratory pattern generator with little effect on timing.
Xu
F
F
Department of Physiology and Biophysics, University of Kentucky, Lexington 45036.
Taylor
R F
RF
McLarney
T
T
Lee
L Y
LY
Frazier
D T
DT
D000136:Acid-Base Equilibrium / Q000502:physiology; D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D003655:Decerebrate State / Q000503:physiopathology; D003907:Dexamethasone / Q000494:pharmacology; D003964:Diaphragm / Q000502:physiology; D004567:Electrodes, Implanted; D004576:Electromyography; D005260:Female; D008297:Male; D012018:Reflex / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000502:physiology; D014628:Vagotomy
D003907:Dexamethasone