Platelet monoamine oxidase B activity in Parkinson's disease: a re-evaluation.
An increase in platelet monoamine oxidase (MAO) B activity in drug-free parkinsonians (n = 6) compared with healthy controls (n = 10) has been confirmed using both phenylethylamine (PEA) and dopamine as substrates, reaching statistical significance in the case of PEA oxidising activity (p < 0.05). Thus, certain reports of raised platelet MAO B activity towards PEA but decreased activity towards dopamine in parkinsonians, raising the possibility of the existence of an abnormal form of MAO B in this condition, cannot be supported.
Jarman
J
J
School of Life Sciences, Kingston University, Kingston upon Thames, United Kingdom.
Glover
V
V
Sandler
M
M
Turjanski
N
N
Stern
G
G
D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010300:Parkinson Disease / Q000201:enzymology*; D010627:Phenethylamines / Q000378:metabolism
D010627:Phenethylamines; C029261:phenethylamine; D008995:Monoamine Oxidase; D004298:Dopamine