title: Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT.
abstract: 2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2 degrees to 4 degrees degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.
authors.affiliation: Department of Pediatrics, Trieste, Italy.
authors.forename: A
authors.initials: A
authors.lastname: de Manzini
authors.forename: M
authors.initials: M
authors.lastname: Andolina
authors.forename: E
authors.initials: E
authors.lastname: Agosti
authors.forename: R
authors.initials: R
authors.lastname: Giorgi
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
authors.forename: L
authors.initials: L
authors.lastname: Bonetti
authors.forename: R
authors.initials: R
authors.lastname: Miniero
authors.forename: A
authors.initials: A
authors.lastname: Busca
authors.forename: F
authors.initials: F
authors.lastname: Porta
authors.forename: A
authors.initials: A
authors.lastname: Lanfranchi
mesh_terms: D001853:Bone Marrow / Q000187:drug effects* / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D006680:HLA Antigens / Q000276:immunology*; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D015994:Incidence; D008775:Methylprednisolone / Q000494:pharmacology* / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014750:Vincristine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D006680:HLA Antigens; D014750:Vincristine; D008775:Methylprednisolone