title: Antibody response and some behaviors as differential traits between two inbred strains of mice (C57BL/6 and BALB/c).
abstract: The goals of this research were to find out if the antibody response and some behaviors are differential traits for murine strains C57BL/6 and BALB/c and to study the influence of strain and isolation on both behavior and the antibody response. 21 C57BL/6 male mice and 28 BALB/c male mice were used; of those, 11 C57BL/6 and 16 BALB/c were kept isolated, and the remaining mice were housed 2 per cage. The tests were Open-fields 1, 2, and 3 (of varying light and sound stimulation), holeboard, light-darkness test, immunization with rat erythrocytes; in addition, the mice were weighed. The traits that best differentiated both strains (according to discriminant analysis) were weight, IgM primary response, and emotional behavior (ambulation, rearing, and defecation in stimulating open-fields). Social isolation (of adult mice) influenced emotional behavior, but not the antibody response.
authors.affiliation: Departamento de Personalidad, Evaluación y Tratamiento Psicológicos, Facultad de Psicología, Universidad de Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vidal
authors.forename: A
authors.initials: A
authors.lastname: Fusté
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000235:genetics* / Q000276:immunology; D001143:Arousal / Q000235:genetics; D001522:Behavior, Animal / Q000502:physiology*; D005838:Genotype; D007121:Immunocompetence / Q000235:genetics / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008810:Mice, Inbred C57BL / Q000276:immunology*; D012934:Social Isolation; D013045:Species Specificity