Induction of class I major histocompatibility complex antigens on adult primate retinal neurons.
The expression of class I major histocompatibility complex (MHC) antigens was examined on adult monkey and human retinal cells following injury caused by dissociation. In a panning assay, neurons and glia demonstrated a rapid induction of class I MHC antigens following enzymatic dissociation, and expression was sustained on regenerating neurons as well as on glia in culture. Class I MHC antigen expression was also enhanced following optic nerve crush of monkey eyes in vivo. These results suggest that the functions of class I MHC antigens may be relevant to primate CNS neurons and glia following injury.
O'Malley
M B
MB
Laboratory of Neurobiology, Rockefeller University, New York, NY.
MacLeish
P R
PR
D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D015395:Histocompatibility Antigens Class I / Q000032:analysis* / Q000276:immunology / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D008252:Macaca fascicularis; D051379:Mice; D008807:Mice, Inbred BALB C; D009457:Neuroglia / Q000276:immunology; D009474:Neurons / Q000276:immunology*; D020221:Optic Nerve Injuries; D012160:Retina / Q000276:immunology*; D012453:Saimiri
D015395:Histocompatibility Antigens Class I