Double t(1;7)(p36;p11) in a megakaryocytic crisis of chronic myelogenous leukemia with variant t(5;9;22).
A 56-year-old man with chronic myelogenous leukemia (CML) who presented with a variant Ph chromosome, t(5;9;22)(q13;q34;q11), developed a unique additional chromosomal change of a double reciprocal t(1;7)(p36;p11) during the accelerated phase. A minor clone that had two copies of 1p+ and a copy of 7p- with a normal chromosome 7 was observed simultaneously. The patient underwent a megakaryocytic crisis. Surface marker of the blasts was positive for CD13, CD33, HLA-DR, CD41a, and CD42b, and negative for CD14 and lymphoid markers. Sequential chromosome analysis suggests that the double t(1;7) was caused by a multistep event consisting of duplication of both derivative chromosomes accompanied by loss of normal chromosomes 1 and 7. This may be the first report of a double reciprocal chromosomal translocation in a hematopoietic neoplasm.
Hirata
J
J
Department of Clinical Laboratory, Kyushu University Hospital, Fukuoka, Japan.
Umemura
T
T
Nishimura
J
J
Sadamura
S
S
Sato
H
H
Nawata
H
H
D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D016313:Genes, abl; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011519:Proto-Oncogenes; D014178:Translocation, Genetic