Möbius syndrome in infant exposed to cocaine in utero.
The pathophysiology of Möbius syndrome has been debated for decades. A vascular etiology is currently favored because it explains the wide clinical spectrum of this syndrome. An infant is reported who was born with Möbius syndrome after a pregnancy complicated by heavy maternal use of cocaine and alcohol. We speculate that cocaine-induced vasoconstriction at a critical time of cerebrovascular development produced a vascular disruption sequence leading to the Möbius syndrome.
Kankirawatana
P
P
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill 27599-7025.
Tennison
M B
MB
D'Cruz
O
O
Greenwood
R S
RS
D000328:Adult; D003042:Cocaine / Q000009:adverse effects*; D005158:Facial Paralysis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013577:Syndrome
D003042:Cocaine