title: A placebo-controlled dose-finding study with bambuterol in elderly patients with asthma.
abstract: A new long-acting bronchodilator prodrug, bambuterol hydrochloride, was tested in a randomized, crossover, and double-blind study in elderly asthmatic patients (aged 64 to 82 years). They received placebo and 5-mg, 10-mg, and 20-mg tablets once daily for a week at each dose. The plasma concentration of the active metabolite, terbutaline, increased linearly with the dose of drug (p < 0.001). Peak expiratory flow rate increased with dose in the morning (p < 0.001 for 10-mg and 20-mg doses) and afternoon (p < 0.05 for 10 mg; p < 0.001 for 20 mg) and was different from placebo for the 10-mg/d and 20-mg/d regimens. The use of supplemental inhaled beta 2-adrenergic agonist therapy was reduced during the night for the 10-mg (p < 0.05) and 20-mg (p < 0.01) doses in comparison to placebo. No significant effects of treatment on blood pressure and pulse were demonstrated. Tremor and palpitations were mild and related to the dose. These data suggest that treatment once daily with bambuterol hydrochloride in a dose of 10 or 20 mg improves pulmonary function and is well tolerated as bronchodilator therapy in elderly patients with asthma.
authors.affiliation: Section of Clinical Pharmacology, University of Manitoba, Winnipeg, Canada.
authors.forename: D S
authors.initials: DS
authors.lastname: Sitar
authors.forename: F Y
authors.initials: FY
authors.lastname: Aoki
authors.forename: C P
authors.initials: CP
authors.lastname: Warren
authors.forename: A
authors.initials: A
authors.lastname: Knight
authors.forename: R F
authors.initials: RF
authors.lastname: Grossman
authors.forename: M
authors.initials: M
authors.lastname: Alexander
authors.forename: S
authors.initials: S
authors.lastname: Soliman
mesh_terms: D000368:Aged; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002802:Cholinesterases / Q000097:blood / Q000187:drug effects; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D010919:Placebos; D011355:Prodrugs / Q000008:administration & dosage* / Q000009:adverse effects; D013726:Terbutaline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D010919:Placebos; D011355:Prodrugs; D002802:Cholinesterases; D013726:Terbutaline; C047766:bambuterol