title: Elevated levels of the p53 tumour suppressor protein in the basal layer of recurrent laryngeal papillomas.
abstract: Using immunocytochemical techniques, recurrent laryngeal papillomas from six adult patients were studied. The p53 tumour suppressor gene protein was detected in the basal epithelial cells in papillomas from all six patients. None was detected in normal epithelium. Elevated levels of p53 protein are usually indicative of its inactivation either by point mutation or by complexing with tumour virus proteins.
authors.affiliation: Beatson Institute for Cancer Research, Glasgow, UK.
authors.forename: L J
authors.initials: LJ
authors.lastname: Clark
authors.forename: K
authors.initials: K
authors.lastname: MacKenzie
authors.forename: E K
authors.initials: EK
authors.lastname: Parkinson
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000737:chemistry*; D010212:Papilloma / Q000737:chemistry* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D016159:Tumor Suppressor Protein p53