title: Exposure to TMXDI (meta) aliphatic isocyanate and TMI (meta) unsaturated aliphatic isocyanate. Clinical and immunological evaluation of 96 workers.
abstract: We evaluated 96 workers employed at facilities that manufacture or use TMXDI (meta) aliphatic isocyanate and TMI (meta) unsaturated aliphatic isocyanate. We used immunoglobulin (Ig) and IgG serum antibody enzyme-linked immunosorbent assay (ELISA) studies and a questionnaire designed to identify symptoms compatible with work-related syndromes such as asthma and hypersensitivity pneumonitis. There were no workers with immunologically induced disease due to TMI isocyanate or TMXDI isocyanate nor were there any workers whose questionnaires suggested new onset of asthma. Approximately 40% of workers experienced some irritant symptoms, mostly upper respiratory or ocular. One worker had low level IgE antibody against TMXDI-HSA but had no work-related respiratory symptoms. Very low-level IgG against TMI-HSA or TMXDI-HSA was present in 7% of workers, all of whom were in the high-exposure category.
authors.affiliation: Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
authors.forename: L C
authors.initials: LC
authors.lastname: Grammer
authors.forename: M A
authors.initials: MA
authors.lastname: Shaughnessy
authors.forename: R A
authors.initials: RA
authors.lastname: Davis
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000276:immunology; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology; D002617:Chemical Industry; D003485:Cyanates / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008452:Maximum Allowable Concentration; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D000395:Air Pollutants, Occupational; D003485:Cyanates; D007074:Immunoglobulin G; D007073:Immunoglobulin E