title: Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure.
abstract: It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This behavioral procedure is commonly known as the conditioned place preference (CPP)-test. At present, a firm theoretical understanding of the mechanisms underlying the production of a CPP are unknown. It is insufficient merely to know that a CPP can result after repeated drug pairings. Rather, it is necessary that the procedure is validated within a learning theory framework. The objective of the present study was, therefore, to establish that what is observed in place preference studies was, indeed, conditioning. This was accomplished by determining whether a cocaine-induced increase in time spent in a drug-paired environment was subject to attenuation following extinction trials. Rats were tested for their initial bias in spending more time in one of two stimulus-specific chambers of a place-conditioning apparatus. On four occasions, rats were injected with 2.5 mg/kg cocaine and confined to their less-preferred chamber whereas, on four alternating sessions, they were conditioned with saline (vehicle) in their preferred chamber. Subsequent testing in the nondrugged state revealed that these rats displayed a significant increase in the time spent in their initially least-preferred environment compared to baseline measurements. Following establishment of this cocaine-induced CPP, the rats were injected only with saline and conditioned for an equal number of sessions (i.e., four).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272-9989.
authors.forename: D J
authors.initials: DJ
authors.lastname: Calcagnetti
authors.forename: M D
authors.initials: MD
authors.lastname: Schechter
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003214:Conditioning, Classical; D003216:Conditioning, Operant / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward
chemical_list: D003042:Cocaine