Extensive cutaneous hyperpigmentation caused by minocycline.
A 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2 1/2 years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal.
Pepine
M
M
Department of Medicine, University of Florida College of Medicine, Gainesville.
Flowers
F P
FP
Ramos-Caro
F A
FA
D000368:Aged; D003875:Drug Eruptions / Q000209:etiology*; D005148:Facial Dermatoses / Q000139:chemically induced; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008854:Microscopy, Electron; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D009260:Nail Diseases / Q000209:etiology; D010859:Pigmentation Disorders / Q000139:chemically induced
D008911:Minocycline