Hair cell development.
Neurobiologists have been challenged by the desire to understand how the highly specialized ultrastructure of the sensory hair cells of the ear develops, how patterns of phenotypically distinct hair cells are formed and regenerate, and how their specific neural connections are formed. Recent research has addressed some of these challenges at the level of cell and molecular biology, focusing on cell proliferation in hair cell epithelia, the mechanisms that control hair cell differentiation, and the developmental interdependencies between hair cells and neurons. The initial identification of some of the homeobox genes and growth factors that are involved in hair cell development has occurred during the past year.
Corwin
J T
JT
Department of Otolaryngology, University of Virginia, School of Medicine, Charlottesville 22908.
Warchol
M E
ME
Kelley
M W
MW
D000818:Animals; D002455:Cell Division / Q000502:physiology; D006198:Hair Cells, Auditory / Q000254:growth & development*; D006801:Humans