title: Isoniazid-associated psychosis: case report and review of the literature.
abstract: OBJECTIVE
  To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect.
  
  
  METHODS
  Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information.
  
  
  METHODS
  All case reports describing isoniazid-associated psychosis were reviewed.
  
  
  METHODS
  Studies were evaluated for the use of isoniazid, symptoms of psychosis, onset of symptoms, and dosage of isoniazid.
  
  
  RESULTS
  The case report is compared with others reported in the literature. The incidence of isoniazid-associated psychosis is rare.
  
  
  CONCLUSIONS
  The mechanism of isoniazid-associated psychosis is uncertain. It appears that isoniazid was associated with the psychosis evident in our patient and in the cases reviewed.
authors.affiliation: Collaborative Clinical Research, Inc., URC II, Cleveland, OH 44106.
authors.forename: K A
authors.initials: KA
authors.lastname: Pallone
authors.forename: M P
authors.initials: MP
authors.lastname: Goldman
authors.forename: M A
authors.initials: MA
authors.lastname: Fuller
mesh_terms: D000368:Aged; D006801:Humans; D015994:Incidence; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D011605:Psychoses, Substance-Induced / Q000209:etiology*
chemical_list: D007538:Isoniazid