HLA-DP positive T cells in patients with polymyositis/dermatomyositis.
The examination of HLA-DP+ T cells in 21 patients with polymyositis/dermatomyositis revealed marked increases [28.5% (SD 16.6%)], compared with the HLA-DQ+ and DR+ T cells. The HLA-DP molecule was expressed on both CD4+ and CD8+ T cells. The majority of HLA-DP+ CD8+ cells were cytotoxic T cells. There was no significant correlation between the proportion of HLA-DP+ T cells and the level of myogenic enzyme, although a decrease in HLA-DP+ T cells after therapy was accompanied by a decrease in myogenic enzymes. However, the proportion of HLA-DP+ CD8+ cells was significantly higher in those patients with active pneumonitis.
Kanai
Y
Y
Department of Internal Medicine and Immunology, Juntendo University, School of Medicine, Tokyo, Japan.
Tokano
Y
Y
Tsuda
H
H
Hashimoto
H
H
Okumura
K
K
Hirose
S
S
D000328:Adult; D000368:Aged; D016827:CD8 Antigens / Q000032:analysis; D003882:Dermatomyositis / Q000150:complications / Q000276:immunology*; D005260:Female; D006682:HLA-DP Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications; D017285:Polymyositis / Q000150:complications / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D016827:CD8 Antigens; D006682:HLA-DP Antigens