[Pulsatile insulin secretion into the portal vein in liver cirrhosis].
To characterize the pulsatile liberation of pancreatic hormones, blood was taken from the portal vein of four patients (three men, one woman; aged 65-71 years) with alcoholic (n = 3) or posthepatitic (n = 1) liver cirrhosis. The concentrations of glucose, insulin, C-peptide and glucagon were measured within one minute. The concentrations of insulin, C-peptide and glucagon varied considerably in intervals of 4.1-6.5 min. The swings in insulin concentration ranged between 17 and 163.5 microU/ml. Oral glucose loading with 100 g increased the insulin and C-peptide swings, but not their periodicity. This indicates that pulsatile insulin secretion is amplitude not rate driven.
Storch
M J
MJ
Abteilung Endokrinologie, Medizinische Universitätsklinik Freiburg.
Rössle
M
M
Kerp
L
L
D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D002096:C-Peptide / Q000097:blood / Q000187:drug effects; D002406:Catheterization, Peripheral; D005260:Female; D005934:Glucagon / Q000097:blood / Q000187:drug effects; D005947:Glucose / Q000008:administration & dosage; D006505:Hepatitis / Q000150:complications; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008103:Liver Cirrhosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000503:physiopathology*; D008297:Male; D011169:Portal Vein; D011673:Pulsatile Flow / Q000187:drug effects; D015641:Radiography, Interventional; D013997:Time Factors
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005934:Glucagon; D005947:Glucose