A DNA polymorphism for lecithin:cholesterol acyltransferase (LCAT) is associated with high density lipoprotein cholesterol concentrations in baboons.
We investigated the effects of a polymorphic PvuII site in the gene for lecithin:cholesterol acyltransferase (LCAT) on serum high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apo A-I) concentrations in a population of 750 pedigreed baboons. We also tested for genotype by diet interactions using data on HDL-C and apo A-I concentrations on two diets (chow and high-cholesterol, saturated fat). A significant (P < 0.001) association between the LCAT genotypes and HDL-C levels was observed. On both diets, animals homozygous for the less common allele had HDL-C levels that averaged 18-19% lower than animals homozygous for the more common allele. HDL-C levels of the heterozygotes were intermediate. The LCAT RFLP accounted for approximately 5% of the variation in HDL-C levels on the two diets. We observed no strong evidence for an LCAT genotype by diet interaction effect.
Kammerer
C M
CM
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78228.
Hixson
J E
JE
Mott
G E
GE
D000483:Alleles; D000818:Animals; D016632:Apolipoprotein A-I / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood*; D004247:DNA / Q000235:genetics*; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D008297:Male; D010215:Papio; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics*; D011110:Polymorphism, Genetic; D013045:Species Specificity
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D004041:Dietary Fats; D004247:DNA; D007862:Phosphatidylcholine-Sterol O-Acyltransferase