title: The HAT4 gene of Arabidopsis encodes a developmental regulator.
abstract: The HAT4 gene from the plant Arabidopsis thaliana encodes a homeo domain protein that contains a leucine zipper motif. Homeo domain-leucine zipper (HD-Zip) proteins have not been found in animal systems, suggesting that HAT4 may define a new family of transcription factors that regulate higher plant development. To explore this possibility, functional studies of HAT4 were carried out in yeast and in transgenic plants. Point mutants of HAT4 isolated in yeast define functionally critical residues within the HD-Zip domain, many of which correspond to highly conserved positions in known homeo domains and leucine zippers. Transgenic plants bearing constructs that alter HAT4 expression exhibit a series of interesting developmental phenotypes, including changes in morphology and developmental rate. Thus, the HAT4 gene of Arabidopsis encodes an HD-Zip protein that functions as a novel developmental regulator.
authors.affiliation: Department of Biochemistry, Beckman Center, Stanford University Medical Center, California 94305-5307.
authors.forename: M
authors.initials: M
authors.lastname: Schena
authors.forename: A M
authors.initials: AM
authors.lastname: Lloyd
authors.forename: R W
authors.initials: RW
authors.lastname: Davis
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development; D029681:Arabidopsis Proteins; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics; D001483:Base Sequence; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics; D005966:Glucuronidase / Q000096:biosynthesis / Q000235:genetics; D018398:Homeodomain Proteins; D016350:Leucine Zippers / Q000235:genetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009838:Oligodeoxyribonucleotides; D010937:Plant Growth Regulators / Q000235:genetics*; D030821:Plants, Genetically Modified; D010957:Plasmids; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D012697:Serine Endopeptidases; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D000099160:LexA Repressor Protein
chemical_list: D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; D003062:Codon; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D005966:Glucuronidase; D018398:Homeodomain Proteins; D009838:Oligodeoxyribonucleotides; D010937:Plant Growth Regulators; D011993:Recombinant Fusion Proteins; D029701:Saccharomyces cerevisiae Proteins; D012697:Serine Endopeptidases; D014157:Transcription Factors; D000099160:LexA Repressor Protein; C080210:ATHB-2 protein, Arabidopsis; C052130:GAL4 protein, S cerevisiae