Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3.
The 70-kDa peroxisomal membrane protein (PXMP1) is a member of the ATP-binding cassette transporter family. In humans, mutations in this gene may be responsible for a subset of patients with Zellweger syndrome, a lethal inborn error of peroxisome assembly. The PXMP1 gene was assigned to human chromosome 1p21-p22 by in situ hybridization and its murine homologue (Pxmp-1) to chromosome 3 by interspecific backcross analysis.
Gärtner
J
J
Department of Pediatrics, Kennedy Krieger Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
Kearns
W
W
Rosenberg
C
C
Pearson
P
P
Copeland
N G
NG
Gilbert
D J
DJ
Jenkins
N A
NA
Valle
D
D
D000818:Animals; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007425:Intracellular Membranes / Q000737:chemistry*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008830:Microbodies / Q000737:chemistry*; D015211:Zellweger Syndrome / Q000235:genetics
D005819:Genetic Markers; D008565:Membrane Proteins; D004247:DNA