title: Influence of labour on epidermal growth factor receptor distribution of the human chorion at term gestation.
abstract: Chorion was obtained from 10 healthy pregnant women at term gestation who were delivered either vaginally (n = 5) or by elective repeat caesarean section before the onset of labour (n = 5). Epidermal growth factor (EGF) receptors in chorionic tissue were evaluated by means of freeze fracture technique (label fracture). They were found to be significantly less, but more frequently coupled, in specimens obtained after labour than before the onset of labour. These findings suggest that a functional activation of EGF receptors in human chorion might occur during labour.
authors.affiliation: Department of Obstetrics and Gynaecology, 2nd University of Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Pasetto
authors.forename: V
authors.initials: V
authors.lastname: Petrozza
authors.forename: C
authors.initials: C
authors.lastname: Ticconi
authors.forename: A
authors.initials: A
authors.lastname: Zicari
authors.forename: F
authors.initials: F
authors.lastname: Carpino
authors.forename: E
authors.initials: E
authors.lastname: Piccione
authors.forename: M
authors.initials: M
authors.lastname: Melis
mesh_terms: D001665:Binding Sites; D002585:Cesarean Section; D002823:Chorion / Q000378:metabolism* / Q000648:ultrastructure; D066246:ErbB Receptors / Q000032:analysis* / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D005614:Freeze Fracturing; D006801:Humans; D007743:Labor, Obstetric / Q000378:metabolism*; D008854:Microscopy, Electron; D011247:Pregnancy; D012086:Reoperation
chemical_list: D066246:ErbB Receptors