Liposomes. A perspective for dermatologists.
We believe that it is unlikely that intact liposomes can cross the stratum corneum and act as carriers of drugs through the skin. However, it is probable that liposomes have the potential to modify the cutaneous biodistribution of applied chemicals (e.g., drugs, toxins, humectants) and thus modify their activity. Liposomal lipids can also penetrate the skin barrier. The effect of this is likely to be varied and lipid dependent, but this phenomenon could hold the most potential for the application of liposomes to topical therapy.
Hope
M J
MJ
Division of Dermatology, University of British Columbia, Vancouver, Canada.
Kitson
C N
CN
D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D003880:Dermatology; D004337:Drug Carriers; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008081:Liposomes; D012869:Skin Absorption
D003879:Dermatologic Agents; D004337:Drug Carriers; D008051:Lipid Bilayers; D008081:Liposomes