Coordinate activity in retinal and cortical development.
New approaches for detecting and manipulating patterns of neuronal activity have revealed diverse strategies for constructing circuits in the developing brain. Spontaneously generated patterns can provide activity-based information before the onset of sensory inputs. In addition to mechanisms based on chemical synaptic communication, coordination of activity via gap junctions can provide important cues for synchronous activity early in circuit formation.
Katz
L C
LC
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology; D012160:Retina / Q000254:growth & development / Q000502:physiology*; D014795:Visual Pathways / Q000254:growth & development / Q000502:physiology