[Risk of hemorrhage with the use of fluoxetine (Prozac) or fluvoxamine (Fevarin)].
Fluoxetine (Prozac) and fluvoxamine (Fevarin) are nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitors prescribed for the treatment of depression. Since these drugs block serotonin reuptake in platelets also, they might under certain conditions lead to clinically significant platelet dysfunction. Four patients are described who developed bleeding during treatment with either fluoxetine or fluvoxamine.
Ottervanger
J P
JP
Bureau Bijwerkingen Geneesmiddelen, Rijswijk.
van den Bemt
P M
PM
de Koning
G H
GH
Stricker
B H
BH
D000328:Adult; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D016666:Fluvoxamine / Q000009:adverse effects*; D006406:Hematoma / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans
D005473:Fluoxetine; D016666:Fluvoxamine