Cyclin D and oncogenesis.
The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.
Motokura
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MGH Cancer Center, Massachusetts General Hospital, Boston 02114.
Arnold
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D000236:Adenoma / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D019938:Cyclin D1; D016213:Cyclins / Q000235:genetics* / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015448:Leukemia, B-Cell / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000235:genetics; D005810:Multigene Family; D015513:Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D010282:Parathyroid Neoplasms / Q000235:genetics; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes
D016213:Cyclins; C000715470:MAS1 protein, human; D015513:Oncogene Proteins; D000090063:Proto-Oncogene Mas; D019938:Cyclin D1