title: Biphenomycin C, a precursor of biphenomycin A in mixed culture.
abstract: A precursor of biphenomycin A in mixed culture of Streptomyces griseorubiginosus No. 43708 with Pseudomonas maltophilia No. 1928 was isolated and characterized. The structure of the precursor, designated biphenomycin C was determined to be a peptide which is composed of biphenomycin A and arginylserine residue (Fig. 1), on the basis of chemical and spectroscopic evidence.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ezaki
authors.forename: N
authors.initials: N
authors.lastname: Shigematsu
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Komori
authors.forename: K
authors.initials: K
authors.lastname: Umehara
authors.forename: H
authors.initials: H
authors.lastname: Imanaka
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004151:Dipeptides / Q000378:metabolism; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011549:Pseudomonas / Q000378:metabolism*; D013291:Streptococcus / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001713:Biphenyl Compounds; D004151:Dipeptides; D010455:Peptides; D010456:Peptides, Cyclic; D011355:Prodrugs; C047536:biphenomycin A; C079816:biphenomycin C