[Androgen-dependent tumor].
Androgen receptor is necessary for the proliferation of androgen-dependent tumors including human prostatic cancer and murine androgen-sensitive tumors. However, androgen-independent tumor containing functional androgen receptor was observed in CS 2 cells, which is a subline of androgen-dependent mouse tumor (SC 115). CS 2 showed a new expression of hst-1, the product of which is a family of FGF. CS 2 secreted a growth factor which promotes growth of CS 2 and original SC 115 in an autocrine and paracrine manner. The role of oncogene(s) and suppressor gene(s) on the progression of the tumor is discussed.
Shimazaki
J
J
Department of Urology, School of Medicine, Chiba University.
Furuya
Y
Y
Sato
N
N
Ichikawa
T
T
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D002455:Cell Division; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000728:Androgens; D006133:Growth Substances; D011944:Receptors, Androgen