title: Treatment of an infant with congenital sodium diarrhea by oral rehydration.
abstract: We have been following a male case of congenital sodium diarrhea (CNaD), who had a distended abdomen, passed watery stools with high sodium concentration, and showed metabolic acidosis in the first week of life. He also showed hyponatremia, low urine sodium, high serum aldosterone and high renin activity. Other possible causes of secretory diarrhea were ruled out. The initial effective treatment was oral supplements of water and electrolytes lost in the fecal fluid: with this he gained weight, and hyponatremia and metabolic acidosis were corrected. Loperamide hydrochloride was administered to increase intestinal absorption of sodium, as the serum prostaglandin was high. Watery diarrhea then improved, but as he passed acholic stools, we stopped and postponed the treatment for a while; the stools then became watery again. Although diarrhea has persisted, he has not shown any abnormalities in growth or psychomotor development for the first two years of life.
authors.affiliation: Pediatric Department, Ohtsu Municipal Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kidowaki
authors.forename: H
authors.initials: H
authors.lastname: Funaki
authors.forename: R
authors.initials: R
authors.lastname: Mizuta
authors.forename: T
authors.initials: T
authors.lastname: Nishiki
authors.forename: H
authors.initials: H
authors.lastname: Takada
mesh_terms: D000471:Alkalosis / Q000209:etiology; D003968:Diarrhea, Infantile / Q000150:complications / Q000151:congenital / Q000378:metabolism / Q000628:therapy*; D005440:Fluid Therapy; D006801:Humans; D007010:Hyponatremia / Q000150:complications; D007231:Infant, Newborn; D008297:Male; D009994:Osmolar Concentration; D015532:Rehydration Solutions / Q000627:therapeutic use*; D012084:Renin-Angiotensin System; D012964:Sodium; D016896:Treatment Outcome
chemical_list: D015532:Rehydration Solutions; D012964:Sodium