title: Newly acquired peri-telomeric heterochromatin in a transgenic mouse lineage.
abstract: Karyotypes of an embryonic stem cell line and normal bone marrow and peripheral blood cells from a transgenic mouse lineage, strain 83, exhibit a novel region of constitutive heterochromatin in the peri-telomeric region of chromosome 3. This heterochromatic region co-localizes with the integration site of the transgene, an 11-Mb tandem insertion of a plasmid containing human beta-globin gene sequences, and is inherited in Mendelian fashion. The significance of this finding is discussed, and a nomenclature for such newly acquired heterochromatic regions is suggested.
authors.affiliation: Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
authors.forename: D
authors.initials: D
authors.lastname: Simon
authors.forename: B B
authors.initials: BB
authors.lastname: Knowles
mesh_terms: D000818:Animals; D002460:Cell Line; D002871:Chromosome Banding; D002875:Chromosomes / Q000737:chemistry / Q000648:ultrastructure*; D005260:Female; D006570:Heterochromatin / Q000648:ultrastructure*; D007621:Karyotyping; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010375:Pedigree; D013234:Stem Cells / Q000648:ultrastructure; D016615:Telomere / Q000648:ultrastructure*
chemical_list: D006570:Heterochromatin