Cell and tumor markers' immunohistochemistry in transitional cell carcinoma of the bladder.
A wide range of cell and tumor markers including the blood group-related isoantigens A, B, O(H) and T-Ag, the cell markers DCA(F36/22) and epithelial membrane antigen (EMA), and the oncogene-related proteins RAP-5p21 and ORP-p21 were investigated by means of immunohistochemistry in selected biopsies from 36 bladder cancer patients with the aim of ascertaining which are of value in patients' survival. A heterogeneous distribution of positivity was found for each marker. In addition, EMA immunostaining correlated significantly (p < 0.05) with patient survival. We conclude that immunohistochemical detection of EMA may provide additional prognostic information in bladder cancer patients.
Lopez-Beltran
A
A
Unit of Anatomical Pathology, Cordoba University Medical School, Spain.
Croghan
G A
GA
Croghan
I
I
Gaeta
J F
JF
D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000957:Antigens, Viral, Tumor / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D007150:Immunohistochemistry; D007519:Isoantigens / Q000032:analysis; D008562:Membrane Glycoproteins / Q000032:analysis; D018396:Mucin-1; D011518:Proto-Oncogene Proteins / Q000032:analysis; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000401:mortality
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D000957:Antigens, Viral, Tumor; D014408:Biomarkers, Tumor; D007519:Isoantigens; D008562:Membrane Glycoproteins; D018396:Mucin-1; D011518:Proto-Oncogene Proteins