The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: I. Effects of whole food diets high in cocoa butter, olive oil, soybean oil, dairy butter, and milk chocolate on the plasma lipids of young men.
The present studies were conducted to evaluate the cholesterolemic effects of whole-food diets high in stearic acid. In study no. 1, normocholesterolemic young men were fed diets high in stearic acid provided by cocoa butter (CB); oleic acid provided by olive oil (OO); linoleic acid provided by soybean oil (SO); and myristic acid (and lauric acid) provided by dairy butter (B). In study no. 2, different subjects with similar baseline characteristics were fed diets high in stearic acid provided by milk chocolate (C), CB, CB+B (4:1, MIX), and myristic (and lauric) acid provided by B. Both studies used a randomized, crossover, double-blind experimental design, and experimental subjects (n = 18 for study no. 1 and n = 15 for study no. 2) in each study consumed every diet for 26 days with a 1-month wash-out period between each experimental period. The diets provided 37% of calories from fat, of which 81% was provided by the test fat. Ten ounces (280 g) C was provided daily by the C diet. In study no. 1, the B diet was hypercholesterolemic, whereas the SO diet was hypocholesterolemic, compared with the other diets. The OO and SO diets were hypocholesterolemic compared with the CB diet. Low-density lipoprotein (LDL) cholesterol levels, in general, paralleled the changes in plasma total cholesterol levels. SO significantly decreased apolipoprotein (apo) B levels compared with the other diets. Plasma very-low density lipoprotein (VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and apo A-I levels were unaffected by the experimental diets.(ABSTRACT TRUNCATED AT 250 WORDS)
Kris-Etherton
P M
PM
Department of Nutrition, Pennsylvania State University, University Park 16802.
Derr
J
J
Mitchell
D C
DC
Mustad
V A
VA
Russell
M E
ME
McDonnell
E T
ET
Salabsky
D
D
Pearson
T A
TA
D000328:Adult; D001053:Apolipoproteins / Q000378:metabolism*; D002079:Butter; D002099:Cacao; D004041:Dietary Fats / Q000494:pharmacology*; D004311:Double-Blind Method; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology; D013024:Soybean Oil / Q000494:pharmacology
D001053:Apolipoproteins; D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D000069463:Olive Oil; D010938:Plant Oils; C052387:cocoa butter; D013024:Soybean Oil; D002079:Butter