Cognitive functions and brain structures: a quantitative study of CSF volumes on Alzheimer patients and healthy control subjects.
In the present study we have investigated the connection between cerebrospinal fluid spaces and cognitive function in patients with senile dementia of Alzheimer type (SDAT) and in successfully aged control subjects. The cerebrospinal fluid (CSF) volumes were measured using a low field MRI technique, and the cognitive functions were assessed with a number of psychometric tests. We found that the SDAT patients showed significantly larger relative volumes in all examined CSF spaces. The largest differences between the groups were found in the volumes of the temporal horns. We also found a significant correlation between the relative CSF volumes in the basal parts of the brain, and episodic memory tests. Significant correlations were also detected between the relative volumes of the lateral ventricles, and degree of dementia as well as between the relative volumes of the lateral ventricles and episodic memory tests.
Wahlund
L O
LO
Department of Psychiatry, St Göran's Hospital, Karolinska Institute, Stockholm, Sweden.
Andersson-Lundman
G
G
Basun
H
H
Almkvist
O
O
Björkstén
K S
KS
Sääf
J
J
Wetterberg
L
L
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000473:pathology / Q000503:physiopathology; D001284:Atrophy; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000473:pathology; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012737:Sex Factors; D013346:Subarachnoid Space / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology; D014796:Visual Perception / Q000502:physiology