Research on isoquinoline derivatives. V--Synthesis and pharmacological evaluation of a series of amidic derivatives of isoquinolin and isocoumarin carboxylic acids.
The synthesis of some amidic derivatives of N-methyl-isoquinolin-1(2H)-one-4-carboxylic acid and of isocoumarin-4-carboxylic acid are reported. These compounds have been evaluated for analgesic, antiinflammatory and antipyretic activities. The central nervous system effects have been also investigated.
Santagati
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Istituto di Chimica Farmaceutica e Tossicologica - Università di Catania, Italy.
Bousquet
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E
Tirendi
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S
Caruso
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A
Catena Cutuli
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VM
Amico-Roxas
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M
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D000431:Ethanol / Q000494:pharmacology; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology; D010538:Peritonitis / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared
D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D003374:Coumarins; D007546:Isoquinolines; D010276:Parasympatholytics; D000431:Ethanol