title: Effects of occupational exposure to mercury and lead on brainstem auditory evoked potentials.
abstract: A study was performed to examine the effects of industrial exposures to lead and mercury on the brainstem auditory pathway by recording brainstem auditory evoked potentials (BAEPs). BAEPs were recorded from 22 workers exposed to lead, from eight exposed to mercury and from two control groups of age- and sex-matched subjects never exposed to neurotoxic substances. The time between BAEP peaks I and V were evaluated. The mean durations of exposure were 9.3 and 11.7 years for lead and mercury, respectively. Blood lead concentration (PbBc) on the morning of the test day was 47.5 micrograms/dl, whereas urinary mercury content at the end of the previous work day was 325 micrograms/g creatinine. Both mercury and lead exposed workers showed a significant prolongation of wave I-V time. In addition, the interwave time was longer in a lead subgroup with the greatest mean level of lead in blood. These results are consistent with other studies and show that BAEPs may provide a sensitive tool for detecting subclinical central neurotoxicity caused by lead and mercury.
authors.affiliation: Institute of Occupational Health, University of Turin, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Discalzi
authors.forename: D
authors.initials: D
authors.lastname: Fabbro
authors.forename: F
authors.initials: F
authors.lastname: Meliga
authors.forename: A
authors.initials: A
authors.lastname: Mocellini
authors.forename: F
authors.initials: F
authors.lastname: Capellaro
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007854:Lead / Q000009:adverse effects*; D008297:Male; D008628:Mercury / Q000009:adverse effects*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D011930:Reaction Time / Q000502:physiology
chemical_list: D007854:Lead; D008628:Mercury