Neutralization of pathophysiological manifestations of Russell's viper envenoming by antivenom raised against gamma-irradiated toxoid.
Rabbits were immunized against gamma-irradiated (100 krads) Russell's viper venom toxoid adsorbed to aluminium phosphate gel. The antivenom (0.1 ml) neutralized 5 LD50, 8 minimum hemorrhagic doses (MHD) and 14 minimum necrotic doses (MND) of venom. The coagulant and protease activities of the viper venom were neutralized more effectively than phospholipase A activity, by the toxoid antivenom.
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Department of Medical Entomology, Calcutta School of Tropical Medicine, India.
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D000818:Animals; D000997:Antivenins / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D005260:Female; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010741:Phospholipases A / Q000378:metabolism; D011817:Rabbits; D012909:Snake Bites / Q000503:physiopathology / Q000628:therapy*; D014757:Viper Venoms / Q000276:immunology* / Q000528:radiation effects / Q000633:toxicity
D000997:Antivenins; D014757:Viper Venoms; D010741:Phospholipases A