title: Research on isoquinoline derivatives. V--Synthesis and pharmacological evaluation of a series of amidic derivatives of isoquinolin and isocoumarin carboxylic acids.
abstract: The synthesis of some amidic derivatives of N-methyl-isoquinolin-1(2H)-one-4-carboxylic acid and of isocoumarin-4-carboxylic acid are reported. These compounds have been evaluated for analgesic, antiinflammatory and antipyretic activities. The central nervous system effects have been also investigated.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica - Università di Catania, Italy.
authors.forename: N A
authors.initials: NA
authors.lastname: Santagati
authors.forename: E
authors.initials: E
authors.lastname: Bousquet
authors.forename: S
authors.initials: S
authors.lastname: Tirendi
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: V M
authors.initials: VM
authors.lastname: Catena Cutuli
authors.forename: M
authors.initials: M
authors.lastname: Amico-Roxas
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D000431:Ethanol / Q000494:pharmacology; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology; D010538:Peritonitis / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D003374:Coumarins; D007546:Isoquinolines; D010276:Parasympatholytics; D000431:Ethanol