title: Interleukin-3 immunoassay in systemic lupus erythematosus patients: preliminary data.
abstract: Systemic lupus erythematosus (SLE) may be associated with thrombocytopenia on one hand and lymphoma on the other. Interleukin-3 (IL-3) may contribute to both conditions. IL-3 is a pleotrophic growth factor affecting the proliferation and differentiation of stem cells to committed progenitors of several hematopoietic lineages including megakaryocytes and lymphocytes. The serum level of IL-3 determined by ELISA was found to be higher in a cohort of 16 patients with SLE in comparison to health controls. The IL-3 levels were highest in 2 patients with SLE and lymphoma. Interestingly, low serum levels were detected in SLE patients with thrombocytopenia. Our preliminary results may point to the role of IL-3 in the hematopoietic changes observed in SLE.
authors.affiliation: Research Institute, Golda Medical Center, Hasharon Hospital, Petach Tiqva, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Fishman
authors.forename: M
authors.initials: M
authors.lastname: Kamashta
authors.forename: M
authors.initials: M
authors.lastname: Ehrenfeld
authors.forename: J
authors.initials: J
authors.lastname: Vianna
authors.forename: G R
authors.initials: GR
authors.lastname: Hughes
authors.forename: D
authors.initials: D
authors.lastname: Sredni
authors.forename: R
authors.initials: R
authors.lastname: Zigelman
authors.forename: G
authors.initials: G
authors.lastname: Sabo
authors.forename: Y
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007377:Interleukin-3 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications; D008223:Lymphoma / Q000097:blood / Q000150:complications; D013921:Thrombocytopenia / Q000097:blood
chemical_list: D007377:Interleukin-3