In humans all U3 genes map to chromosome 17p12-->p11, but in mouse the U3A and U3B genes are located on different chromosomes.
U3 small nucleolar RNA, which participates in eukaryotic rRNA processing, is encoded by a small multigene family in mammals. In humans, the four to six gene copies code for an identical U3 RNA molecule; rodents, however, have two variant forms of these genes, U3A and U3B. We show that all U3 genes in humans map to a single chromosomal locus, 17p12-->-p11, which corresponds exactly to the region of mouse Chromosome 11 where the four U3B genes are clustered. By contrast, in mouse the unique U3A gene copy is not linked to the U3B gene cluster but maps to another chromosome (the B2-B4 region of Chromosome 10).
Mazan
S
S
Laboratoire de Biologie Moléculaire Eucaryote, Centre National de la Recherche Scientifique (CNRS), UPR 9006, Université Paul-Sabatier, Toulouse, France.
Mattéi
M G
MG
Roeckel
N
N
Qu
L H
LH
Bachellerie
J P
JP
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D008040:Genetic Linkage; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009838:Oligodeoxyribonucleotides; D016133:Polymerase Chain Reaction; D012342:RNA, Small Nuclear / Q000235:genetics*
D009838:Oligodeoxyribonucleotides; D012342:RNA, Small Nuclear