Maturation-related changes in tolerance development to hexobarbital after short term treatment with diazepam in the rat.
Male rats at six different ages received diazepam on a 4-day treatment schedule. Cross-tolerance to hexobarbital was tested several times during withdrawal period with an anaesthesia threshold technique. Pattern of cross-tolerance was different at different ages. Thus, age and maturation of the rat is a variable which must be considered in studies of tolerance to diazepam.
Korkmaz
S
S
Department of Pharmacology, University of Umeå, Sweden.
Carlsson
S
S
Wahlström
G
G
D000375:Aging / Q000502:physiology*; D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004361:Drug Tolerance; D004569:Electroencephalography / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology* / Q000523:psychology
D006591:Hexobarbital; D003975:Diazepam