A sclerodermatous syndrome with unusual features following prolonged occupational exposure to organic solvents.
We describe a sclerodermatous syndrome in a middle-aged man who had worked with a wide variety of organic solvents over a prolonged period. Associated changes included cold sensitivity, a restrictive lung defect, peripheral neuropathy, oesophageal dysfunction, labile hypertension and a monoclonal paraproteinaemia. This unique syndrome is discussed in relation to other disorders associated with exposure to organic solvents.
Bottomley
W W
WW
Department of Dermatology, General Infirmary, Leeds, U.K.
Sheehan-Dare
R A
RA
Hughes
P
P
Cunliffe
W J
WJ
D001379:Azathioprine / Q000627:therapeutic use; D002617:Chemical Industry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000188:drug therapy; D012997:Solvents / Q000009:adverse effects*
D012997:Solvents; D011239:Prednisolone; D001379:Azathioprine