Mucosal immunity in primary glomerulonephritis. III. Study of intestinal permeability.
To study the specificity of gut hyperpermeability in primary glomerulonephritis, we investigated intestinal permeability by means of 51Cr-EDTA testing in 20 healthy individuals and in 30 patients with Immunoglobulin A nephropathy (IgA GN), 25 with idiopathic nephrotic syndrome (INS) and 20 with immune complex glomerulonephritis (IC-GN; membranous+membranoproliferative glomerulonephritis). Gut permeability was statistically increased in each patient group versus the controls [controls: 2% (0.4-3.9); IgA GN: 3.25% (0.7-17.70); INS: 3.71% (0.82-10); IC-GN: 3.40% (0.30-16); results are median (range); p < 0.005, nonparametric Mann-Whitney test]. An increase in intestinal permeability exceeding the upper limit of control values (95th percentile) was observed in 36% of IgA GN, 60% of INS and 50% of IC-GN patients. We conclude that intestinal permeability is frequently increased in primary glomerulonephritis and may also be increased in types of glomerulonephritis other than IgA GN.
Rostoker
G
G
Department of Nephrology, INSERM-U 139, Henri-Mondor Hospital, Créteil, France.
Wirquin
V
V
Terzidis
H
H
Petit-Phar
M
M
Chaumette
M T
MT
Delchier
J C
JC
Belghiti
D
D
Lang
P
P
Dubert
J M
JM
Meignan
M
M
D000328:Adult; D005921:Glomerulonephritis / Q000276:immunology* / Q000503:physiopathology; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000503:physiopathology; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology / Q000503:physiopathology; D015433:Glomerulonephritis, Membranous / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000276:immunology*; D009404:Nephrotic Syndrome / Q000276:immunology / Q000503:physiopathology; D010539:Permeability