title: 6-Dimethylamino-9-(beta-D-arabinofuranosyl)-9H-purine: pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys.
abstract: 6-Dimethylamino-9-(beta-D-arabinofuranosyl)-9H-purine (ara-DMAP) effectively prevented the development of rash and appreciably reduced viremia in simian varicella virus-infected monkeys. Doses of 100 and 50 mg/kg/day, administered orally, were highly effective. The lowest dose of 20 mg/kg/day was much less effective in preventing moderate viremia. However, the 20 mg/kg/day did prevent the development of rash in two of three monkeys. All three doses of ara-DMAP reduced liver infection as reflected by lower aspartate aminotransferase values in the sera of the African green monkeys. Orally administered ara-DMAP was rapidly absorbed. However, significant variation among individual monkeys in the AUC values, peak plasma levels, and plasma half-lives were observed.
authors.affiliation: Tulane Regional Primate Research Center, Tulane University, Covington, LA 70433.
authors.forename: K F
authors.initials: KF
authors.lastname: Soike
authors.forename: J L
authors.initials: JL
authors.lastname: Huang
authors.forename: C U
authors.initials: CU
authors.lastname: Lambe
authors.forename: D J
authors.initials: DJ
authors.lastname: Nelson
authors.forename: M N
authors.initials: MN
authors.lastname: Ellis
authors.forename: T A
authors.initials: TA
authors.lastname: Krenitsky
authors.forename: G W
authors.initials: GW
authors.lastname: Koszalka
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000835:Animals, Wild; D000998:Antiviral Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D002644:Chickenpox / Q000188:drug therapy*; D002522:Chlorocebus aethiops; D004341:Drug Evaluation; D006207:Half-Life; D012062:Relative Biological Effectiveness; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014766:Viremia / Q000188:drug therapy
chemical_list: C075035:6-dimethylaminopurine arabinoside; D000998:Antiviral Agents; D001219:Aspartate Aminotransferases; D014740:Vidarabine