title: On line continuous monitoring of subcutaneous tissue glucose is feasible by combining portable glucosensor with microdialysis.
abstract: A new method for continuous measurement of subcutaneous tissue glucose content is introduced: by combining the microdialysis technique with a wearable amperometric glucose sensor, a device for continuous glucose measurement in the subcutaneous tissue was obtained. This device was applied to healthy volunteers (n = 10) over the period of an oral glucose load and to type I diabetic patients (n = 10) under the conditions of daily life. Glucose profiles in both healthy and diabetic persons were followed in the subcutaneous tissue up to 27 hours. This technique will certainly open new perspectives of monitoring and treating diabetic patients.
authors.affiliation: Institut für Diabetes Technologie, Universität Ulm, Germany.
authors.forename: E F
authors.initials: EF
authors.lastname: Pfeiffer
authors.forename: C
authors.initials: C
authors.lastname: Meyerhoff
authors.forename: F
authors.initials: F
authors.lastname: Bischof
authors.forename: F S
authors.initials: FS
authors.lastname: Keck
authors.forename: W
authors.initials: W
authors.lastname: Kerner
mesh_terms: D015374:Biosensing Techniques; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003956:Dialysis / Q000295:instrumentation*; D005947:Glucose / Q000032:analysis*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation
chemical_list: D001786:Blood Glucose; D005947:Glucose