t(5;12)(q31;p12). A clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia.
We report two patients with a myeloproliferative disorder (Philadelphia chromosome-negative chronic myeloid leukemia) and t(5;12)(q31;p12). Until now, only three cases of a translocation (5;12)(q31;p12) have been reported. All investigators had problems classifying their patient's disease into one of the well-defined entities of either MPD or myelodysplastic disorders. We postulate that this translocation may represent a subgroup of patients with features of both chronic myeloid leukemia and chronic myelomonocytic leukemia (CMMoL).
Wessels
J W
JW
Department of Human Genetics, State University, Leiden, The Netherlands.
Fibbe
W E
WE
van der Keur
D
D
Landegent
J E
JE
van der Plas
D C
DC
den Ottolander
G J
GJ
Roozendaal
K J
KJ
Beverstock
G C
GC
D000328:Adult; D015139:Blotting, Southern; D002881:Chromosomes, Human, Pair 12; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics*; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic