Renal and extrarenal sites of action of diuretics.
This paper provides (a) a survey of the basic tubule transport mechanisms of sodium and potassium ions along the nephron, (b) a comparison of the overall renal effects of two diuretic agents (torasemide and furosemide), as assessed by renal clearance techniques, (c) an analysis of the tubule sites of action of torasemide evaluated by free-flow micropuncture and microperfusion techniques, and (d) a brief evaluation of some extrarenal transport effects of loop diuretics.
Giebisch
G
G
Department of Cellular and Molecular Physiology, Yale University, New Haven, CT 06510.
Klein-Robbenhaar
G
G
Klein-Robbenhaar
J
J
Ratheiser
K
K
Unwin
R
R
D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D007684:Kidney Tubules / Q000187:drug effects*; D008138:Loop of Henle / Q000187:drug effects / Q000378:metabolism; D009399:Nephrons / Q000187:drug effects* / Q000378:metabolism; D011188:Potassium / Q000378:metabolism / Q000652:urine*; D012964:Sodium / Q000378:metabolism / Q000652:urine*; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D005665:Furosemide; D012964:Sodium; D011188:Potassium; D000077786:Torsemide