title: Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region.
abstract: Linkage analysis in German breast cancer families with early onset of the disease by using six markers on chromosome 17q11-q24 has been carried out. In the region between markers D17S250 and GH, three markers showed positive LOD scores at an estimated distance of zero. Evidence for linkage is greatest for D17S250, with a LOD score of 2.42.
authors.affiliation: Tumorgenetik, Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Zimmermann
authors.forename: E
authors.initials: E
authors.lastname: Bender
authors.forename: K
authors.initials: K
authors.lastname: Rohde
authors.forename: A
authors.initials: A
authors.lastname: Reis
authors.forename: R
authors.initials: R
authors.lastname: Wiseman
authors.forename: A
authors.initials: A
authors.lastname: Futreal
authors.forename: H
authors.initials: H
authors.lastname: Krause
authors.forename: H
authors.initials: H
authors.lastname: Prokoph
authors.forename: S
authors.initials: S
authors.lastname: Werner
authors.forename: S
authors.initials: S
authors.lastname: Scherneck
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D002461:Cell Line, Transformed; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005858:Germany; D006801:Humans; D008126:Lod Score; D008214:Lymphocytes; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D011110:Polymorphism, Genetic; D011519:Proto-Oncogenes
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers