[The stability of antibiotics administered in and with a parenteral nutrition mixture enriched with branched-chain amino acids. I. Amikacin and gentamycin].
The combined infusion of antibiotics and parenteral nutrition makes it possible to maintain plasmatic nutrient concentrations over time, in turn facilitating the administration of the antibiotics in the dilution and infusion time recommended according to their pharmacokinetic parameters. On the other hand, this type of administration has care benefits for the patient, reducing the risk of infections, and adding to comfort. The technique is also cost-effective, reducing the cost of drug administration, saving on administrative personnel and nursing staff time. The stability of amikacin and gentamicin are determined in vitro at therapeutic concentrations jointly infused with a mixture of parenteral nutrition with polyols and enriched in ramified chain amino acids. A microbiological stability analysis was carried out of the antibiotics in the parenteral nutrition, along with an HPLC aminogram, in order to determine the concentration of amino acids in the combined infusion with the antibiotic. pH measurements were also taken, along with osmolarity and colour change. Both of the antibiotics and the parenteral nutrition employed, and of the combined infusion mixtures. Amikacin and Gentamicin are stable at a concentration of 5 mg/ml and 1.6 mg/ml respectively in a parenteral nutrition mixture enriched in ramified chain amino acids.
de Juana
P
P
Servicio de Farmacia, Hospital Severo Ochoa, Area Sanitaria IX, Leganés-Fuenlabrada-Humanes, España.
Bermejo
T
T
Morell
A
A
García
B
B
Elviro
J
J
Benlloch
M
M
D000583:Amikacin / Q000008:administration & dosage / Q000737:chemistry*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D003116:Color; D004355:Drug Stability; D005839:Gentamicins / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D009994:Osmolar Concentration; D010288:Parenteral Nutrition / Q000379:methods*; D013997:Time Factors
D000597:Amino Acids, Branched-Chain; D005839:Gentamicins; D000583:Amikacin