title: Evoked otoacoustic emissions and pure tone threshold audiometry in patients receiving cisplatinum therapy.
abstract: Eight children and young adults with cancer were evaluated serially using pure tone audiometry as well as registration of click-evoked otoacoustic emissions (EOAE) 1 day prior to therapy as well as after various numbers of doses of cisplatinum. A reduction of EOAE-amplitudes following cisplatinum therapy was observed in all patients. This reduction tended to recover after the end of cisplatinum administration. Since EOAE are believed to result from cochlear bio-mechanical processes, the reduced emissions are interpreted as signs of cochlear dysfunction. We conclude, that EOAE testing may be a simple, non-invasive method that may detect early, transient functional impairment of hearing due to ototoxic agents such as cisplatinum, even in children. Further controlled trials are needed.
authors.affiliation: Department for Disorders of Communication, Johannes Gutenberg University, Mainz, FRG.
authors.forename: P G
authors.initials: PG
authors.lastname: Zorowka
authors.forename: H J
authors.initials: HJ
authors.lastname: Schmitt
authors.forename: P
authors.initials: P
authors.lastname: Gutjahr
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001301:Audiometry, Pure-Tone; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D015834:Cochlear Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005072:Evoked Potentials, Auditory; D005260:Female; D006311:Hearing Disorders / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*
chemical_list: D002945:Cisplatin