Motor neuron diseases and amyotrophic lateral sclerosis: GM1 antibodies and paraproteinemia.
Six of 110 patients (5.5%) with forms of motor neuron disease had abnormal titers of GM1 antibodies of 1:1,600 or higher. Four others came with previously known high titers. Three patients with upper motor neuron (UMN) signs had titers of 1,600; those with probable or no UMN signs had higher titers. Nine patients had conduction block; six of them had abnormal antibody titers, four with 6,400 or higher. Therefore, patients with motor neuron disease and abnormal anti-GM1 titers may have UMN signs or conduction block.
Sanders
K A
KA
Eleanor and Lou Gehrig MDA/ALS Center, Columbia-Presbyterian Medical Center, New York, NY 10032-2699.
Rowland
L P
LP
Murphy
P L
PL
Younger
D S
DS
Latov
N
N
Sherman
W H
WH
Pesce
M
M
Lange
D J
DJ
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000276:immunology*; D010265:Paraproteinemias / Q000150:complications*
D001323:Autoantibodies; D005677:G(M1) Ganglioside