title: Decline of clinical hepatitis B in workers at a general hospital: relation to increasing vaccine-induced immunity.
abstract: Hepatitis B is a well-recognized occupational hazard of health-care workers that can be prevented with vaccination. However, because data on the current epidemiology of hepatitis B virus (HBV) in this population are limited, no consensus exists regarding the requirement for immunization. In 1980-1989, 4,908 exposures of health-care workers to patients' blood and/or other body fluids were reported and evaluated at a general hospital. During this period, 4.8% of patients to whom health-care workers were exposed were positive for hepatitis B surface antigen (HBsAg). In exposed workers, the rate of protective immunity to HBV (measured by antibody to HBsAg) increased from 14% in 1980 to 55% in 1989. Hepatitis B vaccine became available at this hospital in 1983. The increase in antibody to HBsAg was not associated with an increase in antibody to HBV core antigen; this finding suggests that the increase in immunity was primarily vaccine induced. The incidence of reported clinical hepatitis B in health-care workers decreased from 82/100,000 in 1980-1984 to zero in 1985-1989 (odds ratio = 20.06; P = .0012). Thus, in this study, a program of hepatitis B immunization for health-care workers was associated with a significant decline in clinical HBV infection despite continued exposure to patients positive for HBsAg.
authors.affiliation: Department of Pediatrics, Rochester General Hospital, New York 14621.
authors.forename: B P
authors.initials: BP
authors.lastname: Lanphear
authors.forename: C C
authors.initials: CC
authors.lastname: Linnemann
authors.forename: C G
authors.initials: CG
authors.lastname: Cannon
authors.forename: M M
authors.initials: MM
authors.lastname: DeRonde
mesh_terms: D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006769:Hospitals, General; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D009784:Occupational Diseases / Q000453:epidemiology / Q000517:prevention & control*; D009820:Ohio / Q000453:epidemiology; D010564:Personnel, Hospital; D014611:Vaccination
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines