title: Effect of anti-HLA antibodies on the long-term survival of heart and kidney allografts.
abstract: Study of anti-HLA antibodies in a population of 238 primary renal and 199 primary heart allograft recipients showed significant association between development of anti-HLA antibodies and that of chronic allograft rejection. The 5-year renal allograft survival was 70% in recipients without antibodies and 53% in recipients who developed anti-HLA alloantibodies during the first year following transplantation. Heart allograft survival at 5 years was 91% in patients without and 78% in patients with antibodies during the first 12 months posttransplantation. Development of antibodies is associated with acute rejection episodes and probably with the release of soluble HLA antigens.
authors.affiliation: Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
authors.forename: M L
authors.initials: ML
authors.lastname: Barr
authors.forename: D J
authors.initials: DJ
authors.lastname: Cohen
authors.forename: A I
authors.initials: AI
authors.lastname: Benvenisty
authors.forename: M
authors.initials: M
authors.lastname: Hardy
authors.forename: K
authors.initials: K
authors.lastname: Reemtsma
authors.forename: E A
authors.initials: EA
authors.lastname: Rose
authors.forename: C C
authors.initials: CC
authors.lastname: Marboe
authors.forename: V
authors.initials: V
authors.lastname: D'Agati
authors.forename: N
authors.initials: N
authors.lastname: Suciu-Foca
authors.forename: E
authors.initials: E
authors.lastname: Reed
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000917:Antibody Formation; D001161:Arteriosclerosis / Q000209:etiology / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis; D016027:Heart Transplantation / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D006680:HLA Antigens; D006681:HLA-D Antigens; D015395:Histocompatibility Antigens Class I