Syntheses and insulin-like activity of phosphorylated galactose derivatives.
The syntheses of the poly-phosphorylated galactosides 6, 8, 10, 13, 16, and 20, isolated as sodium salts, have been performed. The non-phosphorylated disaccharide 17 and trisaccharide 21 have been prepared via glycosylation of the 2-(trimethylsilyl)ethyl galactosides 3 and 2, respectively, and subsequent complete deprotection. Preliminary insulin-like activity of the phosphorylated derivatives is reported.
Caro
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Grupo de Carbohidratos, Instituto de Química Orgánica General, C.S.I.C., Madrid, Spain.
Martín-Lomas
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Bernabé
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D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology; D005690:Galactose / Q000031:analogs & derivatives*; D005695:Galactosephosphates / Q000138:chemical synthesis / Q000494:pharmacology*; D005697:Galactosides / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D011494:Protein Kinases / Q000187:drug effects*
D005695:Galactosephosphates; D005697:Galactosides; D007328:Insulin; D011494:Protein Kinases; D005690:Galactose