Synthesis of low-toxicity, 5-deoxy-5-fluoro and 5-deoxy-5,5-difluoro derivatives of arbekacin and its analogs, and study of structure-toxicity relationships.
Tsuchiya
T
T
Institute of Bioorganic Chemistry, Kawasaki, Japan.
Shitara
T
T
Umezawa
S
S
Takeuchi
T
T
Hamada
M
M
Tomono
N
N
Umemura
E
E
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D003837:Deoxy Sugars / Q000737:chemistry; D003982:Dibekacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D005461:Fluorine / Q000737:chemistry; D007928:Lethal Dose 50; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003837:Deoxy Sugars; D005461:Fluorine; D003982:Dibekacin; C031986:arbekacin