Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-c]pyridazine and its hydrazone derivatives.
3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.
Gil-Longo
J
J
Department of Pharmacology, University of Santiago de Compostela, Spain.
de los Reyes Laguna
M
M
Verde
I
I
Castro
M E
ME
Orallo
F
F
Fontenla
J A
JA
Calleja
J M
JM
Ravina
E
E
Teran
C
C
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D002118:Calcium / Q000493:pharmacokinetics; D002132:Calcium Radioisotopes; D005260:Female; D006830:Hydralazine / Q000494:pharmacology; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D011724:Pyridazines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D002132:Calcium Radioisotopes; D006834:Hydrazines; D006835:Hydrazones; D007552:Isotonic Solutions; C051865:Krebs-Ringer solution; D011724:Pyridazines; C080265:3-hydrazinocyclopheptyl(1,2-c)pyridazine; C080263:3-(N(1)-(isopropylidene))hydrazinocycloheptyl(1,2-c)pyridazine; C080264:3-(N(1)-(isobutylidene))hydrazinocycloheptyl(1,2-c)pyridazine; D006830:Hydralazine; D002118:Calcium