Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene reveals the beta-amyloid sequence to be normal in cases of the parkinson dementia complex of Guam.
Exons 16 and 17 of the beta-amyloid precursor protein gene has been sequenced in individuals with the amyotropic lateral sclerosis/Parkinson's dementia complex of Guam to test the hypothesis that this disease is an allelic variant of Alzheimer's disease and to test whether sequence differences within beta-amyloid in this population contributes to the non-deposition of this peptide in the disorder. The sequence was normal.
Harlin
M C
MC
Department of Biochemistry, St. Mary's Hospital Medical School, London, United Kingdom.
Crawford
F
F
Perl
D P
DP
Steele
J
J
Hardy
J
J
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000523:psychology; D001483:Base Sequence; D003704:Dementia / Q000235:genetics* / Q000523:psychology; D005091:Exons; D005260:Female; D006141:Guam; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics* / Q000523:psychology
D016564:Amyloid beta-Protein Precursor