Multiple spinal meningiomas: a case of 47 distinct lesions in the absence of neurofibromatosis or identified chromosomal abnormality.
The authors present a unique case of multiple spinal meningiomas with the late development of intracranial lesions. The patient had 47 distinctly separate, yet histologically identical, lesions excised, with many others noted at the time of surgery and by radiographic studies. He was evaluated for neurofibromatosis and was found to have neither Type I nor Type II. Genetic analysis, including restriction fragment length polymorphism analysis, was performed and detected no abnormalities.
Chaparro
M J
MJ
Department of Surgery, College of Medicine, University of California, Irvine.
Young
R F
RF
Smith
M
M
Shen
V
V
Choi
B H
BH
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D008579:Meningioma / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D017253:Neurofibromatoses / Q000235:genetics / Q000473:pathology / Q000601:surgery; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000473:pathology / Q000601:surgery; D012086:Reoperation; D013116:Spinal Cord / Q000473:pathology