Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.
In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.
Smith
S A
SA
Department of Pathology, University of Cambridge, England.
Easton
D F
DF
Ford
D
D
Peto
J
J
Anderson
K
K
Averill
D
D
Stratton
M
M
Ponder
M
M
Pye
C
C
Ponder
B A
BA
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis; D004276:DNA, Satellite / Q000032:analysis; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D011519:Proto-Oncogenes; D011995:Recombination, Genetic
D004273:DNA, Neoplasm; D004276:DNA, Satellite; D005819:Genetic Markers