title: Metabolism of tetralin (1,2,3,4-tetrahydronaphthalene) in Corynebacterium sp. strain C125.
abstract: Corynebacterium sp. strain C125, originally isolated on o-xylene, was selected for its ability to grow on tetralin (1,2,3,4-tetrahydronaphthalene) as the sole source of carbon and energy. The catabolism of tetralin in Corynebacterium sp. strain C125 was shown to proceed via initial hydroxylation of the benzene nucleus at positions C-5 and C-6, resulting in the formation of the corresponding cis-dihydro diol. Subsequently, the dihydro diol was dehydrogenated by a NAD-dependent dehydrogenase to 5,6,7,8-tetrahydro-1,2-naphthalene diol. The aromatic ring was cleaved in the extradiol position by a catechol-2,3-dioxygenase. The ring fission product was subject to a hydrolytic attack, resulting in the formation of a carboxylic acid-substituted cyclohexanone. This is the first report of the catabolism of tetralin via degradation of the aromatic moiety.
authors.affiliation: Department of Food Science, Wageningen Agricultural University, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Sikkema
authors.forename: J A
authors.initials: JA
authors.lastname: de Bont
mesh_terms: D003352:Corynebacterium / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D003512:Cyclohexanones / Q000378:metabolism*; D010101:Oxygen Consumption; D010105:Oxygenases / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000378:metabolism*
chemical_list: D003512:Cyclohexanones; D013764:Tetrahydronaphthalenes; D010105:Oxygenases