Teratogenicity and immunotoxicity of 3,3',4,4',5-pentachlorobiphenyl in C57BL/6 mice.
Administration of 3,3',4,4',5-pentachlorobiphenyl (pentaCB) to female C57BL/6 mice at doses from 130.5 to 522 micrograms/kg body weight resulted in the dose-dependent formation of fetal cleft palate and hydronephrosis. The estimated relative potency of 3,3',4,4',5-pentaCB compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was in the range of < 0.07-0.04. The immunotoxicity of 3,3',4,4',5-pentaCB and two structurally-related congeners, 3,3',4,4'-tetraCB and 3,3',4,4',5,5'-hexaCB, was investigated in male C57BL/6 mice by determining their suppression of the splenic plaque-forming cell response to sheep red blood cells. The potencies of these compounds relative to TCDD were determined from the ratios of their corresponding ED50 values and were 0.77-0.55 (3,3',4,4',5-pentaCB), 1.1-0.29 (3,3',4,4',5,5'-hexaCB) and 0.14-0.03 (3,3',4,4'-tetraCB). These results demonstrate that the immunosuppressive activities of the PCB congeners relative to TCDD were much higher than observed for many other TCDD-like responses in mice and other laboratory animals.
Mayura
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K
Department of Veterinary Anatomy and Public Health, Texas A&M University, College Station 77843.
Spainhour
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CB
Howie
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Safe
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Phillips
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TD
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000633:toxicity*; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity; D011247:Pregnancy; D013154:Spleen / Q000187:drug effects
D007166:Immunosuppressive Agents; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl