title: Glucagon-like peptide-I-(7-37) suppresses hyperglycemia in rats.
abstract: Glucagon-like peptide-(GLP) I-(7-37) is an endogenous hormone that has recently been demonstrated to be a potent insulin secretagogue. In these studies, GLP was administered during oral and intravenous (IV) glucose tolerance tests (OGTT and IVGTT, respectively) to determine whether this peptide could enhance postprandial insulin levels and thus reduce glycemic excursions. Surprisingly, during OGTT, GLP administration did not augment insulin secretion; however, GLP administration resulted in significantly lower glycemic excursions. In fasted rats, glycemic excursions were significantly reduced 10 and 20 minutes after receiving GLP (P < .001). Fed rats that received GLP had virtually no initial increase in plasma glucose level after administration of oral glucose. During IVGTT, glucose alone increased insulin levels eightfold, while administration of both glucose and GLP resulted in a 15-fold increase (P < .001). These IVGTT data support previous studies that show GLP to be a potent and glucose-dependent insulin secretagogue. Furthermore, all of these studies suggest that GLP reduces postprandial glycemic excursion and thus may be useful in the treatment of non-insulin-dependent diabetes mellitus.
authors.affiliation: Joslin Diabetes Center, Boston, MA 02215.
authors.forename: G K
authors.initials: GK
authors.lastname: Hendrick
authors.forename: A
authors.initials: A
authors.lastname: Gjinovci
authors.forename: L A
authors.initials: LA
authors.lastname: Baxter
authors.forename: S
authors.initials: S
authors.lastname: Mojsov
authors.forename: C B
authors.initials: CB
authors.lastname: Wollheim
authors.forename: J F
authors.initials: JF
authors.lastname: Habener
authors.forename: G C
authors.initials: GC
authors.lastname: Weir
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005934:Glucagon / Q000097:blood / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D005951:Glucose Tolerance Test / Q000379:methods; D006943:Hyperglycemia / Q000097:blood*; D007328:Insulin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood / Q000494:pharmacology*; D011498:Protein Precursors / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon