The correlation between urinary and liver taurine levels and between pre-dose urinary taurine and liver damage.
Analysis of data from several studies has shown that urinary taurine levels are highly significantly correlated with liver taurine concentration in control rats. Furthermore, urinary taurine levels measured before dosing with various hepatotoxic agents are significantly correlated with serum AST and ALT values measured after dosing with hepatotoxicants. That is, animals with low urinary taurine values and therefore low liver taurine concentrations tend to show greater hepatic damage. These data suggest that taurine may have a protective function in the liver.
Waterfield
C J
CJ
Toxicology Department, School of Pharmacy, Brunswick Square, London, UK.
Turton
J A
JA
Scales
M D
MD
Timbrell
J A
JA
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis; D008099:Liver / Q000737:chemistry* / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000032:analysis* / Q000633:toxicity* / Q000652:urine
D013654:Taurine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase