title: [Mefloquine and sulfadoxine/pyrimethamine overdose in malaria tropica].
abstract: A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.
authors.affiliation: Abteilung für Infektionen und Chemotherapie, Innere Medizin I, Wien.
authors.forename: H
authors.initials: H
authors.lastname: Burgmann
authors.forename: S
authors.initials: S
authors.lastname: Winkler
authors.forename: F
authors.initials: F
authors.lastname: Uhl
authors.forename: M
authors.initials: M
authors.lastname: Feucht
authors.forename: U
authors.initials: U
authors.lastname: Hellgren
authors.forename: Y
authors.initials: Y
authors.lastname: Bergqvist
authors.forename: S
authors.initials: S
authors.lastname: Feistauer
authors.forename: S
authors.initials: S
authors.lastname: Breyer
authors.forename: W
authors.initials: W
authors.lastname: Graninger
mesh_terms: D000328:Adult; D003975:Diazepam / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000008:administration & dosage; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D015767:Mefloquine / Q000008:administration & dosage / Q000506:poisoning*; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000506:poisoning*; D013413:Sulfadoxine / Q000008:administration & dosage / Q000506:poisoning*; D013881:Thioridazine / Q000008:administration & dosage
chemical_list: D013413:Sulfadoxine; D006220:Haloperidol; D013881:Thioridazine; D003975:Diazepam; D015767:Mefloquine; D011739:Pyrimethamine