Improved or fatal acute disseminated intravascular coagulation in systemic lupus erythematosus.
To analyze the outcome of systemic lupus erythematosus (SLE) associated with acute disseminated intravascular coagulation (DIC) and also to clarify the clinical factor(s) contributing to the outcome, we retrospectively investigated 120 SLE patients treated between 1981 and 1991. Eight of these patients (6.7%) developed acute DIC; four recovered and the other four died within 2 weeks of onset. Infection preceded acute DIC in all these patients. Acute DIC associated with atypical pneumonia was always fatal, while the patients with pharyngitis or urinary tract infection survived when they were treated adequately. Comparison of the dead and surviving groups revealed that the activity of SLE before the onset of DIC, the severity of DIC, and the treatment given for DIC and the coexistent infection were not significantly related to a fatal outcome. However, severe infection such as atypical pneumonia in patients with secondary immunodeficiency was likely to be fatal irrespective of the presence of DIC.
Shimamoto
Y
Y
Department of Internal Medicine, Saga Medical School, Japan.
Ohta
A
A
Sano
M
M
Suga
K
K
Yamaguchi
M
M
D000208:Acute Disease; D000328:Adult; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009026:Mortality; D016896:Treatment Outcome