1;19 translocation in human meningioma.
BACKGROUND
Loss of chromosome 22 represents the most common chromosome abnormality (70%) in meningiomas. The remainder (30%) have a normal karyotype. Not only are the structural changes rare, they also occur simultaneously with various chromosome losses.


METHODS
The authors identified and studied the meningiomas of two patients with standard tumor cell culture technique and chromosome preparation.


RESULTS
Twenty karyotypes from each meningioma had a 46 modal chromosome number with t(1;19) (q21;p13) in all cells.


CONCLUSIONS
The sole change of the (1;19) translocation in meningioma, without any other changes such as chromosome loss, as shown in this study, is unique and has never been reported before in the literature, to the knowledge of the authors. Additional study is needed to learn more about the rate of occurrence and the significant impact on meningeal tumor genesis.
Prempree
T
T
University of Florida, Health Science Center, Jacksonville 32209.
Amornmarn
R
R
Faillace
W J
WJ
Arce
C A
CA
Nguyen
T Q
TQ
D002878:Chromosomes, Human, Pair 1 / Q000502:physiology*; D002888:Chromosomes, Human, Pair 19 / Q000502:physiology*; D002892:Chromosomes, Human, Pair 22 / Q000502:physiology; D005260:Female; D006801:Humans; D007621:Karyotyping; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy; D014178:Translocation, Genetic / Q000235:genetics*