title: Frequency specificity of human distortion product otoacoustic emissions.
abstract: The amplitudes and growth functions of distortion product otoacoustic emissions (DPOE) at 2f1-f2, elicited by two primary tones f1 and f2 with a constant frequency ratio f2/f1 = 1.23 and varying geometric mean values 1, 1.5, 2, 4, 6 and 8 kHz, were measured for 25 normal subjects and 50 patients with sensorineural hearing loss. Partial correlations between DPOE amplitudes and auditory thresholds (0.25 to 8 kHz, half-octave steps) were examined. The amplitude of DPOE evoked by low-intensity primary tones (at or below 62 dB SPL) was strongly correlated only with the auditory threshold at their mean frequency, and DPOE disappeared for local hearing losses larger than about 30 dB. Moreover, DPOE amplitudes did not depend on the basal cochlear state. Confounding effects of middle ear transmission and aging were not significant in this set of experiments. When elicited by higher intensities of primary tones (72 dB SPL), DPOE exhibited a more complex and non-local behavior, and their sensitivity to hearing loss decreased. These results suggest that when low-intensity primaries are used, DPOE patterns provide frequency-specific information on the local cochlear state.
authors.affiliation: Biophysics Department (PAM Neurosensoriel), Faculty of Medicine, Hospital Lariboisière, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Avan
authors.forename: P
authors.initials: P
authors.lastname: Bonfils
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D002648:Child; D003051:Cochlea / Q000503:physiopathology*; D005260:Female; D006309:Hearing; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009622:Noise; D017084:Otoacoustic Emissions, Spontaneous