title: Mapping of the human homologs of the murine paired-box-containing genes.
abstract: Mutations in paired-box-containing (Pax) genes have recently been found to be the primary lesions underlying human genetic disorders such as Waardenburg's Syndrome type 1 and mouse developmental mutants such as undulated (un), splotch (Sp), and small eye (Sey). In addition, PAX-6 is a strong candidate gene for aniridia in man. Eight independent Pax genes have been isolated in the mouse. All eight map to distinct regions of the mouse genome; they do not appear to be clustered in the same way as some groups of homeobox-containing genes. We have now mapped the human homologs of all eight of these genes; PAX genes are found on human Chromosomes (Chr) 1, 2, 7, 9, 10, 11, and 20.
authors.affiliation: Department of Genetics and Biometry, University College London, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Pilz
authors.forename: S
authors.initials: S
authors.lastname: Povey
authors.forename: P
authors.initials: P
authors.lastname: Gruss
authors.forename: C M
authors.initials: CM
authors.lastname: Abbott
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008969:Molecular Sequence Data
chemical_list: D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins