title: Computer-derived regions of interest for the determination of renal parenchymal transit time.
abstract: Renal parenchymal transit time measurements are used in the diagnosis of obstructive nephropathy but parenchymal regions are usually drawn by hand with or without the aid of a functional image. This paper describes three computerized methods for derivation of parenchymal regions from a mean time functional image and compares them with the manual method by processing renogram data from 82 normal, 19 obstructed and 11 dilated nonobstructed kidneys using all four techniques. Receiver-operator characteristic analysis demonstrated the computer methods to be superior to manually drawn regions. The optimum computer method had a sensitivity of 95% and specificity 95% for distinguishing obstructed kidneys from dilated nonobstructed kidneys. The computer method could be readily incorporated into routine renogram analysis programs.
authors.affiliation: Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Li
authors.forename: K A
authors.initials: KA
authors.lastname: Miles
authors.forename: R W
authors.initials: RW
authors.lastname: Barber
authors.forename: E P
authors.initials: EP
authors.lastname: Wraight
mesh_terms: D001330:Electronic Data Processing / Q000379:methods*; D006801:Humans; D007677:Kidney Function Tests; D012372:ROC Curve; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D017263:Technetium Tc 99m Mertiatide; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging*
chemical_list: D017263:Technetium Tc 99m Mertiatide