Replication of Colorado tick fever virus within human hematopoietic progenitor cells.
Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.
Philipp
C S
CS
Division of HIV/AIDS, Centers for Disease Control, Atlanta, Georgia 30333.
Callaway
C
C
Chu
M C
MC
Huang
G H
GH
Monath
T P
TP
Trent
D
D
Evatt
B L
BL
D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003122:Colorado tick fever virus / Q000254:growth & development*; D006224:Cricetinae; D006412:Hematopoietic Stem Cells / Q000382:microbiology*; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D014779:Virus Replication