Temperature in mice after ethanol: effect of probing and regain of righting reflex.
The handling involved in rectally probing a mouse in order to measure body temperature is a stress which results in an increase in body temperature. However, after an injection of ethanol the fall in body temperature caused by ethanol is exacerbated by probing. In mice, decreases in temperature following probing are ethanol-dose dependent and can be generated on both the falling and rising phases of the ethanol induced change in temperature. The effect of probing can be observed when the mice are under the hypnotic influence of ethanol, and regain of righting reflex itself is followed by a fall in temperature. The resumption of motor activity in undisturbed mice following an hypnotic dose of ethanol also is accompanied by a fall in temperature. Therefore, the drop in temperature observed in any of these procedures which involve moving the mice may be attributable to the disruption of heat conservation rather than a stress interaction.
Melchior
C L
CL
Brentwood Division Research, West Los Angeles Veterans Administration, CA.
Allen
P M
PM
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D004856:Postural Balance / Q000187:drug effects; D011187:Posture; D012018:Reflex / Q000187:drug effects*; D013312:Stress, Physiological / Q000503:physiopathology*
D000431:Ethanol