Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.
Current immunotherapy of posterior uveitis is non-specific and limited by drug toxicity and unpredictable relapses on therapy. Alternative modes of therapy being investigated using the rat model of experimental autoimmune uveoretinitis (EAU) have included the induction of tolerance with oral administration of milligram quantities of retinal antigens. In this preliminary report we demonstrate that tolerance to retinal antigens can be induced via the upper respiratory tract with microgram doses of antigen, preventing subsequent induction of EAU.
Dick
A D
AD
Department of Ophthalmology, Medical School, Foresterhill, Aberdeen.
Cheng
Y F
YF
McKinnon
A
A
Liversidge
J
J
Forrester
J V
JV
D000818:Animals; D000941:Antigens / Q000276:immunology*; D019393:Arrestin; D001327:Autoimmune Diseases / Q000628:therapy; D002417:Cattle; D003888:Desensitization, Immunologic / Q000379:methods*; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D005136:Eye Proteins / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D010726:Phosphodiesterase Inhibitors / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000276:immunology*; D012173:Retinitis / Q000628:therapy*; D014605:Uveitis / Q000628:therapy*
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D010726:Phosphodiesterase Inhibitors