Mixed haplotypes and autoimmunity.
Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-E alpha dE beta z, and that this molecule plays a key role in the development of autoimmunity.
Nygard
N R
NR
Beirne Carter Center, Health Sciences Center, University of Virginia, Charlottesville 22908.
McCarthy
D M
DM
Schiffenbauer
J
J
Schwartz
B D
BD
D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D003433:Crosses, Genetic; D005091:Exons; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008181:Lupus Nephritis / Q000235:genetics / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics* / Q000276:immunology; D008957:Models, Genetic; D008969:Molecular Sequence Data
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen