title: Alleviating sleep-related discontinuance symptoms associated with benzodiazepine withdrawal: a new approach.
abstract: There is limited information on the time course of recovery of sleep architecture in patients withdrawn from benzodiazepines (BDZ). This study examined the effects of substituting a new class of hypnotic drugs, namely the cyclopyrrolones, for current BDZs in patients presenting with BDZ dependence. The results indicated a clear improvement in a variety of sleep parameters after commencing with a cyclopyrrolone (zopiclone). These changes remained to some extent after zopiclone was discontinued. Also, the absence of certain withdrawal effects (i.e. rebound insomnia) upon discontinuation of zopiclone allows for patients to be carried through a potentially difficult period after stopping BDZs, while expediting the eventual discontinuation of all hypnotic medication.
authors.affiliation: Sleep Disorders Clinic, University of Toronto, Canada.
authors.forename: C M
authors.initials: CM
authors.lastname: Shapiro
authors.forename: J G
authors.initials: JG
authors.lastname: MacFarlane
authors.forename: A W
authors.initials: AW
authors.lastname: MacLean
mesh_terms: D000328:Adult; D053961:Azabicyclo Compounds; D001569:Benzodiazepines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage*; D012893:Sleep Wake Disorders / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone; D001569:Benzodiazepines