title: Isolated limb perfusion with urokinase for acute ischemia.
abstract: OBJECTIVE
  Isolated limb perfusion with urokinase was used to salvage an acutely ischemic lower limb.
  
  
  METHODS
  Isolated limb perfusion with urokinase over a 90-minute period was used in the treatment of a 69-year-old female patient with acute ischemia of the left leg after thrombosis of a femoral artery bypass graft. Previous balloon embolectomy and heparin therapy had failed. The flow rate was able to be increased progressively without rise in the line pressure during the course of the perfusion, indicating an increase in capacity of the peripheral arterial bed. Fibrinogen and plasminogen levels in the isolated circulation remained low throughout the perfusion. The concentration of cross-linked fibrin degradation particles (d. dimer) rose progressively in the isolated circulation but remained at normal levels in the systemic circulation during perfusion.
  
  
  RESULTS
  Completion angiography demonstrated clearance of thrombus in the popliteal artery and appearance of arteries not seen on preperfusion films. Clinical improvement paralleled the angiographic appearances, with restoration of limb viability.
  
  
  CONCLUSIONS
  We concluded that isolated limb perfusion with use of urokinase is safe and worthy of further investigation.
authors.affiliation: Department of Surgery, University of Sydney, NSW, Australia.
authors.forename: J
authors.initials: J
authors.lastname: May
authors.forename: J
authors.initials: J
authors.lastname: Thompson
authors.forename: K
authors.initials: K
authors.lastname: Rickard
authors.forename: G
authors.initials: G
authors.lastname: White
authors.forename: J P
authors.initials: JP
authors.lastname: Harris
mesh_terms: D000208:Acute Disease; D000368:Aged; D002404:Catheterization; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging; D011859:Radiography; D012008:Recurrence; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D014568:Urokinase-Type Plasminogen Activator