Micronuclei expression in tumors as a test for radiation sensitivity.
Dose-effect curves were determined for the frequency of micronuclei and impairment of cell clonogenicity from two types of tumours of different sensitivity irradiated in situ. Micronucleated cells were measured 24, 48 and 72 h after treatment. The quantitative relationships between cell reproductive death and the induction of micronuclei are the same for both tumours.
Bakker
P J
PJ
Department of Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Tukker
L J
LJ
Stap
J
J
Veenhof
C H
CH
Aten
J A
JA
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D015162:Micronucleus Tests; D009368:Neoplasm Transplantation; D011829:Radiation Dosage; D011836:Radiation Tolerance; D051381:Rats; D012208:Rhabdomyosarcoma / Q000532:radiotherapy* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured; D014516:Ureteral Neoplasms / Q000532:radiotherapy* / Q000648:ultrastructure