title: Differential protein binding of ceftizoxime in cord versus maternal serum.
abstract: Ceftizoxime concentrations are higher in cord blood and amniotic fluid than in maternal blood. More avid binding to fetal serum proteins is a suggested mechanism. We measured ceftizoxime protein binding in fetal and maternal blood and documented significantly less protein binding to fetal proteins (21.9% vs 57.8%).
authors.affiliation: Department of Obstetrics and Gynecology, Tulane University, School of Medicine, New Orleans, LA 70112.
authors.forename: S J
authors.initials: SJ
authors.lastname: Fortunato
authors.forename: S I
authors.initials: SI
authors.lastname: Welt
authors.forename: J T
authors.initials: JT
authors.lastname: Stewart
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D015296:Ceftizoxime / Q000097:blood* / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D015296:Ceftizoxime