Inducible protective processes in animal systems: IV. Adaptation of mouse bone marrow cells to a low dose of ethyl methanesulfonate.
Ethyl methanesulfonate (EMS), a monofunctional alkylating agent, was used in the present investigations to investigate the induction of adaptive response (inducible protective processes) in mitotic cells of Swiss albino mouse. When a low (conditioning) dose of 80 mg/kg body wt was challenged with a subsequent high (challenging) dose of 240 mg/kg body wt, after different time lags, the yield of chromosomal aberrations in bone marrow cells was found to be significantly reduced compared with that of the challenge dose. It appears, therefore, that a low dose of EMS offered resistance to the mitotic cells against further clastogenic effect of any challenge dose of EMS employed. It is clear from the results that the phenomenon of adaptive response can also be encountered in mammalian in vivo systems.
Mahmood
R
R
Department of Studies in Zoology, University of Mysore, India.
Vasudev
V
V
D000222:Adaptation, Physiological; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D004260:DNA Repair; D005020:Ethyl Methanesulfonate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008938:Mitosis
D005020:Ethyl Methanesulfonate