Regulation of liver glucose-6-P dehydrogenase levels in female rats.
1. Gender differences in the dietary regulation of rat liver glucose-6-P dehydrogenase activity, synthesis and mRNA levels were examined. 2. As expected, in normal rats fed a standard chow diet, females have higher G6PD activity than males because they have more G6PD mRNA and therefore a higher rate of G6PD synthesis. 3. In contrast, the decreased dietary induction in female rats is due to a more rapid rate of G6PD degradation rather than a decrease in G6PD mRNA or synthesis.
Holten
D
D
Department of Biochemistry, University of California, Riverside 92521.
Carlos
J R
JR
Reichert
L K
LK
Nakayama
R
R
D000818:Animals; D004032:Diet; D005215:Fasting; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics
D012333:RNA, Messenger; D005954:Glucosephosphate Dehydrogenase