title: Morphological evidence for a cecocolonic junction in man and functional implications.
abstract: The region above, below and in front of the ileocecal valve opening has been studied in man using both light and electron microscopy. A cecocolonic junction, comprising the colonic basal portion of the ileocecal valve, could be demonstrated in man, due to the specific anatomy of the inner portion of the circular muscle. This muscle was arranged in anastomosing cords, richly innervated and enveloped by elastic fibers. Its smooth muscle cells were characterized by extremely wide sarcoplasmic cisternae and cell-to-cell junctions, numerous caveolae and large amounts of glycogen. Interstitial cells were rarely found. This junction might be considered responsible for (1) ileal flow accommodation, (2) colonic active movements and (3) ileocecal valve closing and opening.
authors.affiliation: Department of Human Anatomy and Histology, University of Florence, Italy.
authors.forename: M S
authors.initials: MS
authors.lastname: Faussone-Pellegrini
authors.forename: D
authors.initials: D
authors.lastname: Pantalone
authors.forename: C
authors.initials: C
authors.lastname: Cortesini
mesh_terms: D000368:Aged; D002432:Cecum / Q000648:ultrastructure*; D006801:Humans; D007080:Ileocecal Valve / Q000502:physiology / Q000648:ultrastructure*; D007082:Ileum / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D009130:Muscle, Smooth / Q000166:cytology* / Q000294:innervation