Renal prostaglandins and thromboxane A2 lack a functional significance in the genesis of protein-induced glomerular hyperfiltration in human renal disease.
The study was devised to assess the effects of a protein load (2 g/kg BW) on urinary prostaglandin E2 (PGE2), 6-keto-PGF1 alpha and thromboxane A2 (TxA2) in patients with renal failure of glomerular origin. To this end, 8 women with a glomerular filtration rate of 55 +/- 12 ml/min x 1.73 m2 underwent the following studies: study 1: control; study 2: meat meal; study 3: meat meal+intravenous aspirin; study 4: pretreatment with oral aspirin for 2 days+protocol in study 3. Glomerular hyperfiltration was seen after the meat meal (study 2) and was not suppressed by aspirin (studies 3 and 4). Urinary PGE2, 6-keto-PGF1 alpha and TxA2 increased after the meat meal in study 2 and were suppressed by aspirin in studies 3 and 4. The ratio between vasodilative (PGE2 + 6-keto-PGF1 alpha) and vasoconstrictive (TxA2) autacoids increased during the meat meal (study 2) and was suppressed when aspirin was injected at the time of the oral protein load, thus, the effect of aspirin was much greater for PGE2 and PGF1 alpha than for TxA2. These data do not support that urinary prostaglandin and TxA2 have a direct role in renal hyperfiltration due to an acute protein load.
De Santo
N G
NG
Department of Pediatrics University Federico II, Naples, Italy.
Calò
L
L
Coppola
S
S
Anastasio
P
P
Cantaro
S
S
Favaro
S
S
Capasso
G
G
Borsatti
A
A
D000328:Adult; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology*; D015237:Dinoprost / Q000502:physiology / Q000652:urine; D015232:Dinoprostone / Q000502:physiology / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006940:Hyperemia / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology / Q000503:physiopathology*; D011453:Prostaglandins / Q000502:physiology* / Q000652:urine*; D013928:Thromboxane A2 / Q000502:physiology* / Q000652:urine*
D001095:Arachidonic Acids; D004044:Dietary Proteins; D011453:Prostaglandins; D013928:Thromboxane A2; D015237:Dinoprost; D015232:Dinoprostone; D001241:Aspirin