Diminished hyperaemic response of the hepatic artery to portal venous occlusion (the buffer response) in Asian hybrid minipigs: a comparison of the response to that observed in dogs.
The hyperaemic response of the hepatic artery to portal vein occlusion (the buffer response) and the action of exogenous adenosine upon hepatic artery blood flow was studied in Asian hybrid minipigs as a potential alternative experimental model to that previously developed in dogs. Adenosine produced a dose-dependent hepatic artery vasodilatation, but of lesser extent than that observed in dogs. A greatly diminished buffer response was observed in the pigs compared to that seen in dogs, and could not be replicated consistently. The adenosine uptake inhibitor dipyridamole did not potentiate responses to adenosine or the buffer response. It is concluded that the minipig is an unsuitable alternative model for the study of the hepatic artery buffer response.
Alexander
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B
Department of Surgery, Royal Postgraduate Medical School, London, UK.
Mathie
R T
RT
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005240:Feasibility Studies; D005260:Female; D006499:Hepatic Artery / Q000187:drug effects / Q000502:physiology*; D006504:Hepatic Veno-Occlusive Disease / Q000503:physiopathology*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D013552:Swine; D013556:Swine, Miniature
D000241:Adenosine