title: Methylphenidate and desipramine in hospitalized children: I. Separate and combined effects on cognitive function.
abstract: OBJECTIVE
  The separate and combined effects of methylphenidate and desipramine on cognitive function were investigated in 16 psychiatrically hospitalized children with primary, secondary, and mixed features of attention-deficit hyperactivity disorder and mood disorder.
  
  
  METHODS
  A double-blind, placebo controlled, crossover design was used to investigate drug effects on vigilance, short-term memory, visual problem solving, and higher-order learning.
  
  
  RESULTS
  Methylphenidate alone improved vigilance, both drugs positively affected short-term memory and visual problem solving, and combined drugs affected learning of higher-order relationships.
  
  
  CONCLUSIONS
  Separate and combined drug effects are related to the specific cognitive domain assessed and have implications for neurotransmitter models of action.
authors.affiliation: Department of Psychology, University of Hawaii, Honolulu 96822.
authors.forename: M D
authors.initials: MD
authors.lastname: Rapport
authors.forename: G A
authors.initials: GA
authors.lastname: Carlson
authors.forename: K L
authors.initials: KL
authors.lastname: Kelly
authors.forename: C
authors.initials: C
authors.lastname: Pataki
mesh_terms: D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003891:Desipramine / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use*; D010153:Paired-Associate Learning / Q000187:drug effects; D011340:Problem Solving / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D008774:Methylphenidate; D003891:Desipramine