Tear anti-Chlamydia antibodies in males with chlamydial urethritis.
Conjunctival Chlamydia trachomatis was studied in 50 males with chlamydial urethritis. Conjunctival samples from 49 patients were negative for chlamydial antigen by enzyme immunoassay. However, tear anti-Chlamydia IgA antibodies were found in high titers (> or = 400) in 20 out of the 50 patients. Secretory IgA against Chlamydia in corresponding titers was found in 8 patients. The titers differed significantly from those of the 22 negative control subjects. IgG antibodies were not detected. Tear anti-Chlamydia IgA antibodies are not diagnostic for chlamydial conjunctivitis, but occur concomitantly in patients with chlamydial urethritis.
Vaahtoranta-Lehtonen
H H
HH
Department of Ophthalmology, University of Turku, Finland.
Lehtonen
O P
OP
Forsten
Y
Y
Meurman
O H
OH
Saari
K M
KM
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000254:growth & development / Q000276:immunology*; D003231:Conjunctivitis / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000276:immunology*; D014526:Urethritis / Q000382:microbiology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G