title: Adjuvant chemotherapy for osteogenic sarcoma of the extremity with sequential adriamycin and cisplatin.
abstract: Twenty-nine patients with high-grade nonmetastatic osteogenic sarcoma of the extremities were treated with adjuvant chemotherapy following definitive surgery. Chemotherapy consisted of systemic intravenous Adriamycin and cisplatin in a sequential fashion given for six courses. Nineteen out of 29 patients are alive and continuously disease free over a follow-up period ranging from 9+ to 30+ months. The relapse-free survival was 72%, and overall survival for the entire group was 69%. Median survival is not reached yet. Six out of 29 patients relapsed, of which 1 patient is alive for 6+ months after relapse. Three patients died of chemotherapy toxicity. The results were superior to historical controls treated with surgery alone. The need for more aggressive treatment approaches is discussed.
authors.affiliation: Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
authors.forename: A B
authors.initials: AB
authors.lastname: Pathak
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
authors.forename: R S
authors.initials: RS
authors.lastname: Iyer
authors.forename: S K
authors.initials: SK
authors.lastname: Pai
authors.forename: R
authors.initials: R
authors.lastname: Gopal
authors.forename: K S
authors.initials: KS
authors.lastname: Nadkarni
authors.forename: T K
authors.initials: TK
authors.lastname: Saikia
authors.forename: P A
authors.initials: PA
authors.lastname: Kurkure
authors.forename: C N
authors.initials: CN
authors.lastname: Nair
authors.forename: V R
authors.initials: VR
authors.lastname: Pai
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001132:Arm; D001859:Bone Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007866:Leg; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy*; D016019:Survival Analysis
chemical_list: D004317:Doxorubicin; D002945:Cisplatin