title: Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival.
abstract: OBJECTIVE
  Our purpose was to determine whether the concentration of colony-stimulating factor in ascites of ovarian carcinoma is a prognostic factor for survival.
  
  
  METHODS
  Forty-four ascites samples from patients undergoing primary surgery for ovarian carcinoma were measured for colony-stimulating factor-1 by radioimmunoassay. Retrospective analysis of clinical data allowed comparison of accepted prognostic factors to ascites colony-stimulating factor-1 concentration for impact on survival by means of life-table analysis (Kaplan-Meier) by the Wilcoxon test and the Cox regression methods.
  
  
  RESULTS
  In patients with advanced disease (International Federation of Gynecology and Obstetrics stages III and IV, n = 37) ascites colony-stimulating factor-1 concentration levels below a critical cutoff of 8.59 ng/ml were associated with longer overall survival (p < 0.05) and were a better predictor of survival than any other prognostic factor except zero residual disease after cytoreduction. International Federation of Gynecology and Obstetrics stage, tumor histologic type, malignant cells in fluid, grade of tumor, age, and performance status at presentation were not predictive of outcome.
  
  
  CONCLUSIONS
  Colony-stimulating factor-1 in ascites may be an independent indicator of prognosis in patients with epithelial ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: F V
authors.initials: FV
authors.lastname: Price
authors.forename: S K
authors.initials: SK
authors.lastname: Chambers
authors.forename: J T
authors.initials: JT
authors.lastname: Chambers
authors.forename: M L
authors.initials: ML
authors.lastname: Carcangiu
authors.forename: P E
authors.initials: PE
authors.lastname: Schwartz
authors.forename: E I
authors.initials: EI
authors.lastname: Kohorn
authors.forename: E R
authors.initials: ER
authors.lastname: Stanley
authors.forename: B M
authors.initials: BM
authors.lastname: Kacinski
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D001201:Ascites / Q000209:etiology / Q000378:metabolism* / Q000401:mortality; D003115:Colony-Stimulating Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009994:Osmolar Concentration; D010051:Ovarian Neoplasms / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D011379:Prognosis; D012044:Regression Analysis; D016019:Survival Analysis
chemical_list: D003115:Colony-Stimulating Factors