title: Collectins: pattern recognition molecules involved in first line host defense.
abstract: A group of chimeric molecules comprising globular heads, which contain the carbohydrate recognition domain, and collagen tails are defined as collectins. The mannose-binding proteins, pulmonary surfactant apoproteins A and D and conglutinin all qualify as members of this family, whose function appears to be as pattern recognition molecules involved in the first line of defense in the pre-immune host.
authors.affiliation: Department of Pathology, Boston University School of Medicine, Massachusetts 02118.
authors.forename: K
authors.initials: K
authors.lastname: Sastry
authors.forename: R A
authors.initials: RA
authors.lastname: Ezekowitz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001059:Apoproteins; D001770:Blood Bactericidal Activity; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology*; D003094:Collagen / Q000378:metabolism; D037222:Collectins; D006801:Humans; D018960:Hyaluronan Receptors; D007249:Inflammation; D037241:Mannose-Binding Lectins; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D009895:Opsonin Proteins / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000502:physiology*; D011951:Receptors, Complement / Q000378:metabolism; D012712:Serum Globulins / Q000737:chemistry / Q000502:physiology*
chemical_list: D001059:Apoproteins; C087299:C1QBP protein, human; D002352:Carrier Proteins; D037222:Collectins; D018960:Hyaluronan Receptors; D037241:Mannose-Binding Lectins; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D009895:Opsonin Proteins; D011663:Pulmonary Surfactants; D011951:Receptors, Complement; D012712:Serum Globulins; C032402:complement 1q receptor; C024014:conglutinin; D003094:Collagen