Mapping on human and mouse chromosomes of the gene for the beta-galactoside-binding protein, an autocrine-negative growth factor.
The structural gene for beta-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cystostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously suggested from comparative mapping of several loci. These include the murine SIS oncogene (Pdgfb) and its human homolog, the platelet-derived growth factor-beta polypeptide, PDGFB. The findings presented here extend the genetic homology of the two regions.
Baldini
A
A
CNR Institute of Molecular Genetics, Porto Conte Research and Training Laboratories, Alghero, Italy.
Gress
T
T
Patel
K
K
Muresu
R
R
Chiariotti
L
L
Williamson
P
P
Boyd
Y
Y
Casciano
I
I
Wells
V
V
Bruni
C B
CB
D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D005697:Galactosides; D037161:Galectins; D006388:Hemagglutinins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics; D020574:Proto-Oncogene Proteins c-sis
D005697:Galactosides; D037161:Galectins; D006388:Hemagglutinins; D010982:Platelet-Derived Growth Factor; D011518:Proto-Oncogene Proteins; D020574:Proto-Oncogene Proteins c-sis; D011505:Protein-Tyrosine Kinases