Influence of oral calcium medication on nasal resistance in the nasal allergen provocation test.
Although calcium has been used for several decades to treat allergic diseases of the skin and respiratory tract, controlled studies demonstrating the action of oral preparations in allergic rhinitis are lacking. This placebo-controlled, double-blind, crossover study shows that 1000 mg calcium administered orally significantly inhibits the allergen-induced swelling of the nasal mucosa in the allergen provocation test. Sneezing and secretion, which are allergic symptoms, were not reduced. This study is the first to confirm the positive effect of oral calcium on a symptom of allergic rhinitis.
Bachert
C
C
Medical Department of Heinrich-Heine-University, Düsseldorf, Germany.
Drechsler
S
S
Hauser
U
U
Imhoff
W
W
Welzel
D
D
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D000485:Allergens / Q000276:immunology*; D002118:Calcium / Q000008:administration & dosage* / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects*; D009299:Nasal Provocation Tests; D012123:Pulmonary Ventilation / Q000187:drug effects
D000485:Allergens; D002118:Calcium