title: Possible interaction between fluoxetine and pimozide causing sinus bradycardia.
abstract: Fluoxetine has been reported to have interactions with antipsychotics and other antidepressants with symptoms of toxicity of these drugs. We report a case of a possible interaction with pimozide which led to a potentially life threatening bradycardia. Careful monitoring should be done when these two drugs are prescribed at the same time, especially in the elderly and in patients with cardiac disease.
authors.affiliation: Department of Psychiatry, John A. Burns School of Medicine, University of Hawaii.
authors.forename: I
authors.initials: I
authors.lastname: Ahmed
authors.forename: P G
authors.initials: PG
authors.lastname: Dagincourt
authors.forename: L G
authors.initials: LG
authors.lastname: Miller
authors.forename: R I
authors.initials: RI
authors.lastname: Shader
mesh_terms: D000368:Aged; D001146:Arrhythmia, Sinus / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced*; D003702:Delusions / Q000188:drug therapy / Q000523:psychology; D003704:Dementia / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D010259:Paranoid Disorders / Q000188:drug therapy / Q000523:psychology; D010868:Pimozide / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005473:Fluoxetine; D010868:Pimozide