111In-labeled Mn-metalloporphyrin for tumor imaging.
We synthesized and developed a new tumor imaging agent, 111In-labeled metalloporphyrin (111In-ATN-10) which consists of a carrier (ATN-10) of the tumor imaging possessing both a non-radioactive manganese complex in the porphyrin ring and a bifunctional chelating group (DTPA) attached to its side chain. The images of the three kinds of tumors were delineated more clearly by 111In-ATN-10 than 67Ga-citrate. Moreover, there was no photosensitivity in ATN-10. 111In-ATN-10 is studied as a new tumor positive scintigraphic agent instead of 67Ga-citrate.
Nakajima
S
S
Division of Surgical Operation, Asahikawa Medical College, Japan.
Yamauchi
H
H
Sakata
I
I
Hayashi
H
H
Yamazaki
K
K
Maeda
T
T
Kubo
Y
Y
Samejima
N
N
Takemura
T
T
D000818:Animals; D002951:Citrates / Q000493:pharmacokinetics*; D019343:Citric Acid; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D003905:Deuteroporphyrins / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D005260:Female; D007205:Indium Radioisotopes / Q000493:pharmacokinetics*; D007941:Leukemia P388 / Q000000981:diagnostic imaging* / Q000378:metabolism; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D011877:Radionuclide Imaging; D051381:Rats; D011918:Rats, Inbred SHR; D014018:Tissue Distribution
D002951:Citrates; D003905:Deuteroporphyrins; D007205:Indium Radioisotopes; C080234:ATN 10; D019343:Citric Acid