title: Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model.
abstract: A review of the structure-function relationships for normal articular cartilage is provided. This provides the foundation for understanding the roles played by collagen, proteoglycan and water in determining the material properties of the tissue. A summary of biomechanical and compositional changes in human osteoarthritic cartilage is also presented. Finally, the results from our recent interdisciplinary study on an experimental osteoarthritis model is described, and new hypotheses are proposed on the initiating factors responsible for the increase of tissue hydration. At present, it appears that microstructural alterations, rather than compositional changes, of the collagen-proteoglycan solid matrix are responsible for the early increase of hydration and the deterioration of biomechanical properties of articular cartilage.
authors.affiliation: Orthopaedic Research Laboratory, Columbia University, New York.
authors.forename: L A
authors.initials: LA
authors.lastname: Setton
authors.forename: V C
authors.initials: VC
authors.lastname: Mow
authors.forename: F J
authors.initials: FJ
authors.lastname: Muller
authors.forename: J C
authors.initials: JC
authors.lastname: Pita
authors.forename: D S
authors.initials: DS
authors.lastname: Howell
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D010003:Osteoarthritis / Q000473:pathology* / Q000503:physiopathology