title: Radiobiological intercomparison of p(45)+Be and p(65)+Be neutron beams for lung tolerance in mice after single and fractionated irradiation.
abstract: The lung tolerance in mice after single and fractionated irradiations with p(45)+Be and p(65)+Be neutrons produced at the isochronous cyclotron "CYCLONE" of Louvain-la-Neuve (Belgium) was studied. Cobalt-60 gamma rays were used for control irradiations. The end point was the dose which was lethal to 50% of the mice by 180 days (LD50/180). On a log-log plot, the slope (+/- SE) of the relationship between total isoeffect dose and fraction number decreases from 0.34 +/- 0.01 for gamma rays to 0.19 +/- 0.01 for p(65)+Be and 0.12 +/- 0.01 for p(45)+Be neutrons. The data have been analyzed using the linear-quadratic (LQ) model. The alpha/beta ratio (+95% confidence interval) increases from 5.3 (4.3-6.4) for gamma rays to 20.7 (16.7-24.9) for p(65)+Be and 37.9 (25.8-65.8) for p(45)+Be. The RBEs of neutrons relative to gamma rays were estimated from the LQ parameters, to 1.15 and 1.19 for a dose of 14 Gy gamma rays and 2.02 and 2.47 for a dose of 2 Gy gamma rays for p(65)+Be and p(45)+Be neutrons, respectively. The neutron RBE of the p(45)+Be relative to the p(65)+Be calculated from the ratio of their respective RBEs relative to gamma rays reaches 1.03 and 1.23 for doses of 14 and 2 Gy gamma-ray equivalent, respectively. These data are compared with other published data on lung tolerance after irradiation with lower-energy neutrons and with data obtained previously in our laboratory on mouse jejunum and Vicia faba.
authors.affiliation: Université Catholique de Louvain, Laboratoire de Radiobiologie, Bruxelles, Belgium.
authors.forename: V
authors.initials: V
authors.lastname: Grégoire
authors.forename: M
authors.initials: M
authors.lastname: Beauduin
authors.forename: J
authors.initials: J
authors.lastname: Gueulette
authors.forename: B M
authors.initials: BM
authors.lastname: De Coster
authors.forename: M
authors.initials: M
authors.lastname: Octave-Prignot
authors.forename: S
authors.initials: S
authors.lastname: Vynckier
authors.forename: A
authors.initials: A
authors.lastname: Wambersie
mesh_terms: D000818:Animals; D001608:Beryllium; D017357:Cyclotrons; D005214:Fast Neutrons; D005260:Female; D008168:Lung / Q000528:radiation effects*; D051379:Mice; D011829:Radiation Dosage; D011836:Radiation Tolerance; D012062:Relative Biological Effectiveness
chemical_list: D001608:Beryllium