title: Hepatic vagotomy does not disrupt the normal satiation of NaCl appetite.
abstract: The necessity of the hepatic branch of the vagus nerve for the normal satiation of NaCl intake under the condition of sodium depletion was tested. Sham- or hepatic-vagotomized male, Long-Evans rats were sodium depleted by injection with Lasix (furosemide, 10 mg) and were maintained overnight on sodium-deficient diet and water. The intake of 0.3 M NaCl during a 2-h salt appetite test was not significantly different between the sham- and hepatic-vagotomized groups. In a second group of sham- or hepatic-vagotomized rats, a load of 7.5 ml of 0.5 M NaCl was given by gavage at 15 or 90 min prior to a 1-h NaCl appetite test. The preload decreased NaCl intake equivalently in both groups. Gastric emptying of a preload of NaCl at 15 and 90 min was also the same for sham- and hepatic-vagotomized rats. Thus, the hepatic branch of the vagus nerve is not necessary for the normal short-term satiation of NaCl intake under the condition of acute sodium depletion produced by furosemide.
authors.affiliation: New York Hospital-Cornell University Medical College, Bourne Laboratory, White Plains 10605.
authors.forename: S P
authors.initials: SP
authors.lastname: Frankmann
authors.forename: G P
authors.initials: GP
authors.lastname: Smith
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology*; D004326:Drinking / Q000502:physiology; D005746:Gastric Emptying / Q000502:physiology; D008099:Liver / Q000294:innervation*; D008297:Male; D051381:Rats; D012528:Satiety Response / Q000502:physiology*; D012965:Sodium Chloride / Q000008:administration & dosage; D014630:Vagus Nerve / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D012965:Sodium Chloride