title: Sinus arrest associated with continuous-infusion cimetidine.
abstract: The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous-infusion cimetidine 50 mg/hour. The arrhythmias were temporally related to cimetidine administration, disappeared after dechallenge, and did not recur during ranitidine treatment. This is the first reported case of sinus arrest associated with continuous-infusion cimetidine.
authors.affiliation: Department of Pharmacy and Internal Medicine, Akron General Medical Center, OH 44307.
authors.forename: D T
authors.initials: DT
authors.lastname: Hulisz
authors.forename: J R
authors.initials: JR
authors.lastname: Welko
authors.forename: D E
authors.initials: DE
authors.lastname: Heiselman
mesh_terms: D000328:Adult; D001919:Bradycardia / Q000139:chemically induced*; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications; D008297:Male
chemical_list: D002927:Cimetidine