Comparison of sequences of the 78 kDa gastrin-binding protein and some enzymes involved in fatty acid oxidation.
1. The amino acid sequences of enzymes possessing enoyl-CoA hydratase activity have been aligned with each other and with the sequences of related proteins. 2. The amino acid sequences of enzymes possessing 3-hydroxyacyl-CoA dehydrogenase activity have been similarly aligned. 3. The N-terminal half of the 78 kDa gastrin-binding protein (Baldwin et al., J. biol. Chem. 261, 12,252-12,257, 1986) is related to the enoyl-CoA hydratase family, while the C-terminal half is related to the 3-hydroxyacyl-CoA dehydrogenase family. 4. Evolutionary trees for the two families are presented.
Baldwin
G S
GS
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, P.O. Royal Melbourne Hospital, Victoria, Australia.
D015094:3-Hydroxyacyl CoA Dehydrogenases / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002175:Candida / Q000201:enzymology; D002352:Carrier Proteins / Q000737:chemistry*; D004746:Enoyl-CoA Hydratase / Q000737:chemistry*; D004926:Escherichia coli / Q000201:enzymology; D005227:Fatty Acids / Q000378:metabolism*; D063991:Mitochondrial Trifunctional Protein; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes; D010084:Oxidation-Reduction; D010802:Phylogeny; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013552:Swine
D002352:Carrier Proteins; D005227:Fatty Acids; D009097:Multienzyme Complexes; D015094:3-Hydroxyacyl CoA Dehydrogenases; D063991:Mitochondrial Trifunctional Protein; D004746:Enoyl-CoA Hydratase