Measurement of plaque thickness and evaporative water loss in psoriasis with PUVA and dithranol treatment.
Pre-treatment plaque thickness determined the rate at which psoriasis responded to PUVA treatment, taking longer with thicker plaques. For dithranol, the rate of response to treatment was independent of pre-treatment plaque thickness. Plaques of psoriasis that showed the greatest evaporative water loss before treatment took longest to clear with PUVA. At the time of clinical clearing the water loss had returned to that of adjacent, uninvolved skin. With dithranol the evaporative water loss did not return to normal levels but remained considerably elevated when the plaque was clinically clear.
Rogers
S
S
City of Dublin Skin and Cancer Hospital, Ireland.
D000875:Anthralin / Q000627:therapeutic use*; D006801:Humans; D011701:PUVA Therapy / Q000379:methods*; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000473:pathology; D014870:Water Loss, Insensible / Q000187:drug effects* / Q000502:physiology
D000875:Anthralin