HLA antigen frequencies in renal transplant recipients and non-immunosuppressed patients with non-melanoma skin cancer.
An increased frequency of human leukocyte antigen (HLA)-DR1 was found in 49 non-immunosuppressed patients with non-melanoma skin cancer (NMSC), being highest in patients under the age of 60 with multiple squamous cell carcinomas (SCC). Of 266 patients receiving long-term immunosuppression following renal transplantation 46 (17%) were found to have NMSC. No increase in HLA-DR1 was found in renal transplant recipients (RTR) with non-melanoma skin cancer (RTR+C) when compared with matched renal transplant recipients without skin cancer (matched RTR-C), or when compared with healthy controls. There was an increased frequency of DQw2 in RTR+C, most pronounced in RTR with SCC (61.9% compared with 18.75% in matched RTR-C), giving a relative risk of 13.98. We found statistically significant differences in the frequency of a number of HLA antigens on comparing RTR+C with healthy controls, but none of these differences were found when we compared RTR+C against matched RTR-C.
Glover
M T
MT
Department of Dermatology, Royal London Hospital, U.K.
Bodmer
J
J
Bodmer
W
W
Kennedy
L J
LJ
Brown
J
J
Navarrete
C
C
Kwan
J T
JT
Leigh
I M
IM
D000951:Antigens, Neoplasm / Q000032:analysis*; D002280:Basal Cell Carcinoma / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis; D015798:HLA-DR1 Antigen / Q000032:analysis; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology / Q000276:immunology*
D000951:Antigens, Neoplasm; D006680:HLA Antigens; D006683:HLA-DQ Antigens; D015798:HLA-DR1 Antigen