The current role of small-bowel transplantation in intestinal failure.
Short bowel syndrome is the clinical manifestation of a fundamental reduction in the functional intestinal absorptive surface area and malabsorption. The development of total parenteral nutrition has improved the natural course of this disease. Home parenteral nutrition-related complications continue to generate significant morbidity and mortality for these patients. Small-bowel transplantation is an alternative to home parenteral nutrition. There are significant risks of graft rejection and the potential complications of long-term immunosuppression. Small-bowel transplantation is an option, but it should be reserved for patients no longer considered candidates for continued home parenteral nutrition.
Hiyama
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D006801:Humans; D007421:Intestine, Small / Q000637:transplantation*; D016331:Parenteral Nutrition, Home / Q000009:adverse effects / Q000379:methods*; D011788:Quality of Life; D012778:Short Bowel Syndrome / Q000523:psychology / Q000601:surgery* / Q000628:therapy; D015996:Survival Rate; D014184:Transplantation, Homologous / Q000276:immunology / Q000379:methods* / Q000401:mortality