title: Investigations on the synthesis and properties of arylpiperazinylalkyl derivatives of some dihydro- and tetrahydropyrido[2,3-d]pyrimidines.
abstract: Synthesis of S- and N-arylpiperazinylalkyl derivatives of ethyl 2-thio-4-oxo-3,4-dihydro- and 2,4-dioxo-1,2,3,4-tetrahydropyrido [2,3-d] pyrimidine-5-carboxylate is described. Some of the obtained compounds are pharmacologically active.
authors.affiliation: Department of Chemistry of Drugs - School of Medicine, Wroclaw, Tamka, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sladowska
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D010879:Piperazines; D011619:Psychotropic Drugs; D011743:Pyrimidines; D006916:5-Hydroxytryptophan