title: Effects of long-term running exercise on canine femoral head articular cartilage.
abstract: After long-term running program (40 km/day) anterior and posterior tissue samples from canine femoral head were labeled ex vivo in the presence of 35S-SO4. Sulfate incorporation rates did not differ between runner and control groups. The statistically significant changes in runners included a decreased uronic acid concentration (p < or = 0.02) and proportion of extractable proteoglycans (p < or = 0.05) as well as increased concentration of tissue uronic acid after 4 M GuCl extraction (p < or = 0.05) in the posterior area. These results support an idea of strengthened cartilage tissue after this kind of motion and load.
authors.affiliation: Department of Anatomy, University of Kuopio, Finland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lammi
authors.forename: T P
authors.initials: TP
authors.lastname: Häkkinen
authors.forename: J J
authors.initials: JJ
authors.lastname: Parkkinen
authors.forename: M
authors.initials: M
authors.lastname: Hyttinen
authors.forename: M
authors.initials: M
authors.lastname: Jortikka
authors.forename: H J
authors.initials: HJ
authors.lastname: Helminen
authors.forename: M
authors.initials: M
authors.lastname: Tammi
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism / Q000502:physiology*; D002809:Chondroitin Sulfates / Q000378:metabolism; D002810:Chondroitinases and Chondroitin Lyases; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D019286:Endopeptidase K; D005260:Female; D005270:Femur Head / Q000502:physiology*; D005688:Galactosamine / Q000378:metabolism; D005944:Glucosamine / Q000378:metabolism; D006868:Hydrolysis; D007632:Keratan Sulfate / Q000378:metabolism; D010805:Physical Conditioning, Animal; D005082:Physical Exertion; D011453:Prostaglandins / Q000096:biosynthesis; D012697:Serine Endopeptidases / Q000378:metabolism; D014048:Tolonium Chloride; D014574:Uronic Acids / Q000378:metabolism
chemical_list: D011453:Prostaglandins; D014574:Uronic Acids; D014048:Tolonium Chloride; D005688:Galactosamine; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate; D012697:Serine Endopeptidases; D019286:Endopeptidase K; D002810:Chondroitinases and Chondroitin Lyases; D005944:Glucosamine