title: Hodgkin disease in Iranian children.
abstract: The epidemiological pattern of Hodgkin disease (HD) was studied in 139 Iranian children with an age range of 2.5-15 years (mean age 8.3) over a 17-year period (1972-1989). The main features observed were: a high male to female ratio of 3.2:1, a high frequency of HD in toddlers and young school children (73%), the prevalence of mixed cellularity subtype (74.5%) and rare occurrence of lymphocyte depletion subtype (2%) the high occurrence of constitutional symptoms (57%) and the high rate of stage III and IV patients (73.5%). Response to the treatment consisting mainly of chemotherapy and/or radiotherapy was favourable and overall and disease-free survival rates of 91.4% and 74.2% were achieved over a follow up period of 6 months-17 years. According to these findings the epidemiological pattern of Iranian children with HD is similar to that occurring in rural areas of developed countries.
authors.affiliation: Department of Paediatric Haematology/Oncology Shohada Medical Centre, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Alebouyeh
authors.forename: P
authors.initials: P
authors.lastname: Vossough
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D009367:Neoplasm Staging; D015996:Survival Rate