Small actin-binding proteins: the beta-thymosin family.
Thymosin beta 4 is a major actin monomer binding protein present at high concentration in many vertebrate cells and cell lines. The interactions of actin with thymosin beta 4, actobindin and profilin are compared. Nine beta-thymosins have been identified; six have been shown to bind to actin. Regulation of the synthesis of thymosin beta 10 and thymosin beta 4 has been found in brain development and after stimulation of several cell types, respectively. The extracellular effects of thymosin beta 4 still need clarification.
Nachmias
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Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia 19104-6058.
D000199:Actins / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D003285:Contractile Proteins; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D051304:Profilins; D015800:Protozoan Proteins; D051381:Rats; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D013947:Thymosin / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D000199:Actins; D002352:Carrier Proteins; D003285:Contractile Proteins; D008840:Microfilament Proteins; C495738:PFN1 protein, human; C495739:Pfn1 protein, mouse; C495740:Pfn1 protein, rat; D051304:Profilins; D015800:Protozoan Proteins; C050869:actobindin protein, Acanthamoeba; D013947:Thymosin