title: Unravelling the tangled web at the microtubule-organizing center.
abstract: The last year has seen dramatic progress in the use of genetic and biochemical approaches to identify microtubule-organizing center components. The use of vertebrate and invertebrate egg extracts has allowed the development of novel assays for centrosome duplication and activation. A variety of mutations in fungi are being used to sort out the pathway of spindle pole body duplication.
authors.affiliation: Department of Molecular Biology, Princeton University, New Jersey 08455-1014.
authors.forename: M D
authors.initials: MD
authors.lastname: Rose
authors.forename: S
authors.initials: S
authors.lastname: Biggins
authors.forename: L L
authors.initials: LL
authors.lastname: Satterwhite
mesh_terms: D000818:Animals; D002455:Cell Division; D016213:Cyclins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000648:ultrastructure; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005658:Fungi / Q000235:genetics / Q000648:ultrastructure; D007448:Invertebrates / Q000235:genetics / Q000378:metabolism; D008868:Microtubule Proteins / Q000235:genetics / Q000378:metabolism; D008870:Microtubules / Q000648:ultrastructure*; D008938:Mitosis; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D008941:Spindle Apparatus / Q000648:ultrastructure*
chemical_list: D016213:Cyclins; D005656:Fungal Proteins; D008868:Microtubule Proteins