title: Comparison of enterotoxin production, cytotoxin production, serogrouping, and antimicrobial susceptibilities of Clostridium difficile strains isolated from AIDS and human immunodeficiency virus-negative patients.
abstract: We analyzed and compared Clostridium difficile strains isolated from diarrheic stools of 49 human immunodeficiency virus (HIV)-negative and 50 AIDS patients. Our results suggest that distribution patterns of serogroups are different in these two populations. Serogroup C (which has been previously reported to be very resistant to antimicrobial agents) represents 66.0 and 18.4% of the isolates from AIDS and HIV-negative patients, respectively (P < 0.001); the selection of serogroup C could be explained by multiple antibiotic pressure to which AIDS patients have been subjected.
authors.affiliation: Department of Microbiology, Saint-Antoine Hospital, Paris 12, France.
authors.forename: F
authors.initials: F
authors.lastname: Barbut
authors.forename: C
authors.initials: C
authors.lastname: Depitre
authors.forename: M
authors.initials: M
authors.lastname: Delmée
authors.forename: G
authors.initials: G
authors.lastname: Corthier
authors.forename: J C
authors.initials: JC
authors.lastname: Petit
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000382:microbiology*; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000032:analysis; D016360:Clostridioides difficile / Q000145:classification / Q000302:isolation & purification / Q000502:physiology*; D003967:Diarrhea / Q000150:complications / Q000382:microbiology*; D004768:Enterotoxins / Q000032:analysis; D006801:Humans; D008826:Microbial Sensitivity Tests; D012703:Serotyping
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile