[Evaluation of lidocaine metabolite (monoethylglycinexylidide) as a liver function test].
In order to determine whether or not the lidocaine metabolism, monoethylglycinexylidide (MEGX) formation, could be used as a liver function test, we measured the serum levels of MEGX in 38 patients. There were significant correlations between values of MEGX (MEGX15, MEGX30, AUC15-30, AUC0-180) and conventional liver function tests (ICG R15, AT III, T. Bil). It appeared that value of MEGX 30 had maximum factor loading on conventional liver function tests by using principal component analysis. The advantage of adapting the MEGX formation as a liver function test of drug metabolism is simplicity of the method. MEGX formation could be useful index of the total liver function.
Shimanuki
K
K
Department of Surgery, Omiya Medical Center, Jichi Medical School.
Suzuki
W
W
Sakurabayashi
I
I
Kiyozaki
H
H
Shinohara
K
K
Soda
K
K
Kai
T
T
Satake
M
M
Miyata
M
M
D005069:Evaluation Studies as Topic; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D008107:Liver Diseases / Q000503:physiopathology; D008111:Liver Function Tests / Q000592:standards*; D008297:Male; D008875:Middle Aged
D008012:Lidocaine; C001173:monoethylglycinexylidide