title: Effect of fibrin glue on postlaminectomy scar formation.
abstract: An experimental study in rats has been carried out with the aim of studying the scar formation over the spinal dura in the presence of fibrin glue. Although the main action of fibrin glue is the enhancement of wound healing by increasing the fibrous tissue, our present data suggest that this re-absorbable biomaterial diminishes the epidural scar formation, at least the first two weeks after laminectomy. This finding leads us to consider the use of fibrin glue over spinal duramater when it is likely that reoperation may become necessary in a short period of time after a laminectomy.
authors.affiliation: Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: A
authors.initials: A
authors.lastname: Arias
authors.forename: S
authors.initials: S
authors.lastname: Oya
authors.forename: R
authors.initials: R
authors.lastname: Martinez
authors.forename: M
authors.initials: M
authors.lastname: Zurita
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology*; D004388:Dura Mater / Q000187:drug effects / Q000473:pathology; D004824:Epidural Space; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D007796:Laminectomy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D015718:Fibrin Tissue Adhesive