Successful control of hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis using magnesium carbonate and calcium carbonate as phosphate binders.
To avoid the use of aluminium as a phosphate binder, patients on CAPD who were stable were dialysed against a peritoneal dialysis fluid which was magnesium free. A mixture of calcium and magnesium carbonate was used as a phosphate binder over a period in excess of 1 year. Vitamin D analogues were used in the majority. Results show satisfactory control of hyperparathyroidism with mean parathyroid hormone concentration for the group of 121 pg/ml (normal < 100 pg/ml), calcium concentration of 2.41 mmol/l, magnesium 0.97 mmol/l, phosphate 1.36 mmol/l and aluminium 0.35 mmol/l (normal < 0.2 mumol/l). These results were as good as and better in some respects than a minority using calcium carbonate alone or remaining on aluminium hydroxide, the latter remaining on Mg-containing CAPD fluid.
Parsons
V
V
Department of Renal Medicine, King's College, London, UK.
Baldwin
D
D
Moniz
C
C
Marsden
J
J
Ball
E
E
Rifkin
I
I
D002118:Calcium / Q000097:blood; D002119:Calcium Carbonate; D015314:Dialysis Solutions; D006801:Humans; D006934:Hypercalcemia / Q000517:prevention & control; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008274:Magnesium / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects / Q000379:methods*; D010710:Phosphates / Q000097:blood
D015314:Dialysis Solutions; D010281:Parathyroid Hormone; D010710:Phosphates; C005479:magnesium carbonate; D002119:Calcium Carbonate; D008274:Magnesium; D002118:Calcium