The association of Chiari type I malformation and neurofibromatosis type 1.
The association of neurofibromatosis type 1 (NF1) with Chiari malformations of the cerebellum and brain stem has been reported on only two previous occasions. The pathogenesis of both conditions has remained unclear, although the Chiari type I malformation is most likely due to hypoplasia of the posterior fossa with subsequent extension of the cerebellum through the foramen magnum. NF1 is also associated with a variety of cerebral dysplasias. We present a patient with both of these dysplastic lesions whose Chiari malformation was asymptomatic.
Dooley
J
J
Vaughan
D
D
Riding
M
M
Camfield
P
P
D000293:Adolescent; D001139:Arnold-Chiari Malformation / Q000150:complications*; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*