Calbistrins, novel antifungal agents produced by Penicillium restrictum. I. Production, taxonomy of the producing organism and biological activity.
A novel antibiotic complex, named the calbistrins, has been discovered in the culture broth of a soil fungus. The producing organism, designated AB 1875C-28, was identified as a strain of Penicillium restrictum. Calbistrin A, the most potent of the 4-membered complex, has MICs of 0.78 micrograms/ml against Candida albicans. Only poor activity is observed against non-candida yeasts, filamentous fungi and bacteria.
Jackson
M
M
Anti-infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064.
Karwowski
J P
JP
Humphrey
P E
PE
Kohl
W L
WL
Barlow
G J
GJ
Tanaka
S K
SK
D000818:Animals; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D005285:Fermentation; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D010407:Penicillium / Q000737:chemistry* / Q000145:classification; D011090:Polyenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000935:Antifungal Agents; D011090:Polyenes