title: Effects of a controlled-release albendazole capsule on parasitism and production from grazing Merino ewes and lambs.
abstract: Effects of a controlled-release albendazole capsule (CRC) on nematode parasitism and production of Merino ewes and lambs were investigated in a replicated grazing experiment between August 1986 and July 1989. The experiment was conducted on a site where the naturally occurring parasites were benzimidazole-resistant, with double the recommended dose of oxfendazole reducing faecal egg counts of Trichostrongylus colubriformis by less than 50%. Two CRC treatments were compared with a minimal treatment control and the widely-used strategic control program, Wormkill. Egg counts and worm burdens of major parasite species of ewes and of lambs before and after weaning were significantly reduced by use of the CRC in ewes before lambing or in lambs at weaning. These parasitological effects were reflected in increased productivity of CRC ewes and lambs. Ewes given CRCs lost less weight and grew more wool during lactation than ewes given Wormkill or control treatments, while their lambs gained more weight and had heavier fleeces than lambs from Wormkill or control treatments. Where lambs were weaned by removing ewes from the lambing paddock, administration of the CRC at weaning to lambs whose dams had also been treated with the CRC did not result in improved production when compared with lambs from ewes dosed with CRCs and treated after weaning according to the Wormkill program. Some possible uses for the CRC in ewes and lambs were identified.
authors.affiliation: CSIRO Division of Animal Health, Pastoral Research Laboratory, Armidale, New South Wales.
authors.forename: I A
authors.initials: IA
authors.lastname: Barger
authors.forename: J W
authors.initials: JW
authors.lastname: Steel
authors.forename: B R
authors.initials: BR
authors.lastname: Rodden
mesh_terms: D015766:Albendazole / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002214:Capsules; D003692:Delayed-Action Preparations; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology; D005260:Female; D008297:Male; D009349:Nematode Infections / Q000517:prevention & control / Q000662:veterinary*; D010270:Parasite Egg Count; D011247:Pregnancy; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D014935:Wool / Q000254:growth & development
chemical_list: D001562:Benzimidazoles; D002214:Capsules; D003692:Delayed-Action Preparations; D015766:Albendazole; C011030:oxfendazole