Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5.
A daunorubicin-blocked mutant strain RPM-5 derived from a new baumycin-producing Streptomyces sp. D788 accumulated a major precursor metabolite D788-1 (10-carboxyl-13-deoxocarminomycin) and nine minor metabolites in the culture broth. Five among them were new with a substituent at C-10 or the altered side chains at C-9. Isolation, purification and identification of all anthracycline metabolites produced by strain RPM-5 are described with their antitumor activities against L1210 cells.
Yoshimoto
A
A
Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
Fujii
S
S
Johdo
O
O
Kubo
K
K
Nishida
H
H
Okamoto
R
R
Takeuchi
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002360:Carubicin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D005285:Fermentation; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012334:RNA, Neoplasm / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; C015018:baumycins; C048661:10-carboxy-13-deoxocarminomycin; D002360:Carubicin; D003630:Daunorubicin