Immune modulation of biologic systems in renal somatic cells.
The various theories discussed here suggest that somatic renal cells are susceptible to biologic modulation by the immune system independent of an inflammatory effect. (1) The mode of repression of type IV collagen synthesis by novel, soluble antigen-binding proteins, the down-regulation of class II MHC expression with interruption of antigen presentation to epithelia after selective gene regulation by antibody, and the diverse interactions of antibody with renal glomerular cells producing functional disturbances in endocytosis and permselectivity; (2) modification of surface-antigen composition; (3) alteration of matrix deposition, remodeling and composition; (4) biophysical perturbation of cytoskeletal and cell membrane components; (5) and lastly, alterations in cell adhesion through cell-surface alterations, all lend testimony to the richness of the signal transduction pathways in somatic cells. Although the preceding examples represent only a small fraction of those which may take place within the glomerular and tubular microenvironments, these paradigms may nevertheless serve as new models upon which one can consider the multitude of potential communications between disparate biologic systems that connect in complex organisms.
Yee
J
J
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Neilson
E G
EG
D000818:Animals; D000906:Antibodies; D000941:Antigens / Q000378:metabolism; D002352:Carrier Proteins / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology / Q000473:pathology; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology; D007687:Kidney Tubules, Proximal / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000906:Antibodies; D000941:Antigens; D002352:Carrier Proteins