title: Synthesis and pharmacological activity of imidazo[2,1-b]benzothiazole acids.
abstract: We have prepared twelve imidazo[2,1-b]benzothiazole carboxylic and acetic acids by reaction of substituted 2-aminobenzothiazoles with ethyl bromopyruvate and 4-chloroacetoacetate, respectively. The acids, obtained from esters by hydrolysis, were tested for their antiinflammatory, analgesic and ulcerogenic activities.
authors.affiliation: Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Facoltà di Farmacia, Università di Perugia.
authors.forename: G
authors.initials: G
authors.lastname: Grandolini
authors.forename: V
authors.initials: V
authors.lastname: Ambrogi
authors.forename: L
authors.initials: L
authors.lastname: Perioli
authors.forename: P
authors.initials: P
authors.lastname: de Caprariis
authors.forename: F
authors.initials: F
authors.lastname: Palagiano
authors.forename: M G
authors.initials: MG
authors.lastname: Rimoli
authors.forename: E
authors.initials: E
authors.lastname: Lampa
authors.forename: M
authors.initials: M
authors.lastname: D'Amico
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D011247:Pregnancy; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D013844:Thiazoles