Interleukin-3 immunoassay in systemic lupus erythematosus patients: preliminary data.
Systemic lupus erythematosus (SLE) may be associated with thrombocytopenia on one hand and lymphoma on the other. Interleukin-3 (IL-3) may contribute to both conditions. IL-3 is a pleotrophic growth factor affecting the proliferation and differentiation of stem cells to committed progenitors of several hematopoietic lineages including megakaryocytes and lymphocytes. The serum level of IL-3 determined by ELISA was found to be higher in a cohort of 16 patients with SLE in comparison to health controls. The IL-3 levels were highest in 2 patients with SLE and lymphoma. Interestingly, low serum levels were detected in SLE patients with thrombocytopenia. Our preliminary results may point to the role of IL-3 in the hematopoietic changes observed in SLE.
Fishman
P
P
Research Institute, Golda Medical Center, Hasharon Hospital, Petach Tiqva, Israel.
Kamashta
M
M
Ehrenfeld
M
M
Vianna
J
J
Hughes
G R
GR
Sredni
D
D
Zigelman
R
R
Sabo
G
G
Shoenfeld
Y
Y
D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007377:Interleukin-3 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications; D008223:Lymphoma / Q000097:blood / Q000150:complications; D013921:Thrombocytopenia / Q000097:blood
D007377:Interleukin-3