Localization of HSP90 in rat brain.
1. In rats, HSP90 (90-kDa heat shock protein) was abundant in the brain compared with the liver and kidney. Immunohistochemical studies showed the presence of HSP90 in almost all neurons in the brain. 2. On immunoblotting using an anti-HSP90 antibody, HSP90 was present in a lower amount in the medulla oblongata and spinal cord. 3. In the pituitary gland, some of superficial cells of the anterior lobe adjacent to the middle lobe was specifically stained with anti-HSP90 antibody.
Itoh
H
H
Department of Biochemistry, Akita University School of Medicine, Japan.
Tashima
Y
Y
Eishi
Y
Y
Okeda
R
R
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001923:Brain Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D006360:Heat-Shock Proteins / Q000032:analysis*; D015151:Immunoblotting; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000906:Antibodies; D006360:Heat-Shock Proteins