title: Allergic contact reaction to dexpanthenol: lymphocyte transformation test and evidence for microsomal-dependent metabolism of the allergen.
abstract: In a patient with contact dermatitis, dexpanthenol was found to be the causative allergen. There was a positive reaction to dexpanthenol on patch testing. Controls did not show any positive reactions to dexpanthenol on patch testing. Additionally, an LTT was performed. After preincubation with dexpanthenol-modified microsomes, we observed an increase in lymphocyte proliferation to dexpanthenol, in comparison to dexpanthenol without microsomes, suggesting that microsomal metabolism plays a rôle in the pathogenesis of dexpanthenol sensitization, because microsomes are known to possess drug metabolizing enzymes such as cytochrome P450.
authors.affiliation: Department of Dermatology, University of Cologne, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hahn
authors.forename: S
authors.initials: S
authors.lastname: Röseler
authors.forename: R
authors.initials: R
authors.lastname: Fritzsche
authors.forename: R
authors.initials: R
authors.lastname: Schneider
authors.forename: H F
authors.initials: HF
authors.lastname: Merk
mesh_terms: D002455:Cell Division; D017449:Dermatitis, Allergic Contact / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008213:Lymphocyte Activation; D008861:Microsomes / Q000187:drug effects* / Q000378:metabolism; D010205:Pantothenic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000276:immunology / Q000378:metabolism; D010328:Patch Tests; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
chemical_list: D010205:Pantothenic Acid; C007288:dexpanthenol