Mixed chimaerism; detection and significance following BMT.
Residual recipient haematopoietic cells may coexist with donor haemopoietic tissue following BMT. This is known as mixed chimaerism. The incidence of mixed chimaerism varies with the sensitivity of the detection system used; DNA based methodologies are the most sensitive. The influence of mixed chimaerism on leukaemia relapse and graft rejection is unclear. The lineages in which mixed chimaerism occurs may affect outcome.
McCann
S R
SR
Department of Haematology and Genetics, St James Hospital, Dublin, Ireland.
Lawler
M
M
D000741:Anemia, Aplastic / Q000473:pathology / Q000601:surgery; D016465:Bone Marrow Purging; D016026:Bone Marrow Transplantation / Q000473:pathology*; D002678:Chimera; D006085:Graft Survival; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000473:pathology / Q000601:surgery; D014411:Neoplastic Stem Cells / Q000473:pathology