Arthropathy secondary to ciprofloxacin in an adult cystic fibrosis patient.
OBJECTIVE
To report a case of possible ciprofloxacin-induced arthropathy in an adult patient with cystic fibrosis (CF).


METHODS
A 25-year-old man with CF received three separate courses of ciprofloxacin therapy at usual doses for acute pulmonary exacerbations of his disease. During the second and third courses, the patient experienced bilateral swelling of his knees between two to three weeks after initiation of each course. Both times symptoms markedly decreased after discontinuation of the drug. The patient had no prior history of arthropathy. Furthermore, during the last two acute exacerbations of his CF, he did not receive ciprofloxacin and did not experience any symptoms of arthropathy.


CONCLUSIONS
Prior cases of quinolone-induced arthropathy involving pediatric CF patients or adult patients without CF have been reported in the literature. We report the first case of such an arthropathy in an adult patient with CF. The findings are supported by a rechallenge with the drug.


CONCLUSIONS
It is likely that ciprofloxacin may produce arthropathy in adult as well as pediatric patients with CF. Quinolones should be considered as a possible cause of arthropathy in adult CF patients.
Samuelson
W M
WM
Department of Medicine, Duke University Medical Center, Durham, NC.
Pleasants
R A
RA
Whitaker
M S
MS
D000328:Adult; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000188:drug therapy*; D006801:Humans; D007592:Joint Diseases / Q000139:chemically induced*; D008297:Male
D002939:Ciprofloxacin