Structural-functional relationships in type I mesangiocapillary glomerulonephritis.
We quantitated glomerular and cortical interstitial structures in nine type I mesangiocapillary glomerulonephritis (MCGN) patients aged 6 to 20 years whose creatinine clearance (CCr) was 10 to 129 ml/min/1.73 m,2 as compared to age-matched normal controls. Mean glomerular volume and mesangial volume fraction [Vv(mes/glom)] were increased and the percentage of the capillary endothelial circumference which was defined as filtration surface was decreased in type I MCGN patients. Vv(mes/glom) was inversely related to filtration surface area per glomerulus (r = -0.73, P < 0.05) and directly to volume density of cortical interstitium [Vv(int/cortex)] (r = +0.90; P < 0.01). Vv(mes/glom) (r = -0.87; P < 0.01), filtration surface area per glomerulus (r = +0.83; P < 0.01) and Vv(int/cortex) (r = -0.86; P < 0.01) were correlated with CCr. Thus, in type I MCGN, measures both of glomerular and of cortical interstitial structure are highly correlated with glomerular function.
Hattori
M
M
Department of Pediatrics, Hyogo College of Medicine, Japan.
Kim
Y
Y
Steffes
M W
MW
Mauer
S M
SM
D000293:Adolescent; D000328:Adult; D001485:Basement Membrane / Q000473:pathology; D002648:Child; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005920:Glomerular Mesangium / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male
D003404:Creatinine