title: The nude mouse as an in vivo model for human breast cancer invasion and metastasis.
abstract: Human breast cancer xenografts only rarely invade and metastasize in nude mice, and have therefore only had limited use as a model for studying mechanisms involved in breast cancer spreading. However, recent reports describe differences not only between various cell lines but also between strains of immune-deficient mice in terms of providing a model for studies of the invasive and metastatic capability of human breast cancer xenografts. Genetic labelling of human cancer cells with the lacZ gene is described as a specific and highly sensitive method for identification of micrometastases in such a model.
authors.affiliation: Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Brünner
authors.forename: B
authors.initials: B
authors.lastname: Boysen
authors.forename: J
authors.initials: J
authors.lastname: Rømer
authors.forename: M
authors.initials: M
authors.lastname: Spang-Thomsen
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005819:Genetic Markers; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D013045:Species Specificity; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
chemical_list: D005819:Genetic Markers