title: Sustained-release levodopa in parkinsonian patients with nocturnal disabilities.
abstract: It is now well recognized that poor quality of sleep, with fragmentation as the main characteristic, is a common problem in patients with Parkinson's disease. The effect of a sustained-release levodopa compound (Prolopa HBS) was assessed in a long-term (12 months) study of 15 patients presenting with distressing night time symptoms prolopa HBS was administered only ante noctem, without changing the usual daytime treatment. It appeared that alleviation of nighttime akinesia, reflected by the ability to turn around in bed, was perceived as the most worthwhile improvement.
authors.affiliation: Department of Neurology, Middelheim General Hospital, Antwerp, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Van den Kerchove
authors.forename: J
authors.initials: J
authors.lastname: Jacquy
authors.forename: M
authors.initials: M
authors.lastname: Gonce
authors.forename: P P
authors.initials: PP
authors.lastname: De Deyn
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003692:Delayed-Action Preparations; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage* / Q000009:adverse effects; D008137:Longitudinal Studies; D008875:Middle Aged; D009069:Movement Disorders / Q000150:complications; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D012893:Sleep Wake Disorders / Q000150:complications* / Q000188:drug therapy
chemical_list: D003692:Delayed-Action Preparations; D007980:Levodopa