Glucocorticoids, lipocortins and the immune response.
Glucocorticoids are immunosuppressive and antiinflammatory agents that act through multiple mechanisms. This review highlights recent evidence that lipocortin-1, a member of the annexin family of calcium-binding proteins, can be induced by glucocorticoids, and may mediate some of the effects of glucocorticoids through putative lipocortin-1 receptors, which have been found on the surface of phagocytic cells. Recent advances in annexin biology have been drawn together to formulate a novel hypothesis for the regulation of inflammation.
Goulding
N J
NJ
Department of Rheumatology, Medical College of St. Bartholomew's Hospital, London, UK.
Guyre
P M
PM
D000818:Animals; D017305:Annexin A1 / Q000096:biosynthesis / Q000502:physiology*; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007111:Immunity, Cellular / Q000502:physiology*; D007249:Inflammation / Q000503:physiopathology*; D008954:Models, Biological; D010586:Phagocytes / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011961:Receptors, Fc / Q000037:antagonists & inhibitors; D011994:Recombinant Proteins / Q000494:pharmacology
D017305:Annexin A1; D005938:Glucocorticoids; D011961:Receptors, Fc; D011994:Recombinant Proteins