title: [A case report of central pontine myelinolysis associated with serum hyperosmolality after open heart surgery].
abstract: A 65-year-old man was admitted with a sudden onset of dyspnea. Severe mitral regurgitation due to torn chordae tendinae was revealed on UCG. Mitral valve replacement was undergone. The postoperative course was complicated with a low cardiac output syndrome which was successfully treated with IABP, catecholamines and vasodilators. However, stupor developed on the 4 th postoperative day, following by tetrapregia on the 8 th day, and deep coma on the 15 th day respectively. Laboratory studies of the 4 th day disclosed the following values, serum sodium 150 mEq/l, blood urea nitrogen 84.7 mg/dl, blood sugar 184 mg/dl and calculated serum osmolality 354 mOsm/l. Cranial CT of the 15 th day showed an obscure low density area in the central pons which was strongly suggestive of central pontine myelinolysis (CPM). His CNS symptoms improved dramatically after administration of thyrotropin-releasing hormone tartrate (TRH-T). A diagnosis of CPM was made on MRI of the 41 st day. He discharged without any neurological deficit on the 62 nd day.
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Metropolitan Hiroo General Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Konno
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashibe
authors.forename: T
authors.initials: T
authors.lastname: Maemura
authors.forename: K
authors.initials: K
authors.lastname: Goto
authors.forename: M
authors.initials: M
authors.lastname: Kamaki
mesh_terms: D000368:Aged; D001806:Blood Urea Nitrogen; D006348:Cardiac Surgical Procedures; D003244:Consciousness Disorders / Q000209:etiology*; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D006955:Hypernatremia / Q000150:complications*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000601:surgery; D009994:Osmolar Concentration; D011149:Pons; D011183:Postoperative Complications; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use
chemical_list: D013973:Thyrotropin-Releasing Hormone