[Effect of the administration of intralipid on liquid filtration rate and pressure of the pulmonary artery in isolated lung of rabbits].
BACKGROUND
We study the effect on Intralipid on pulmonary circulation.


METHODS
A 10% infusion of Intralipid was administered at a dose of 0.5/kg in 14 isolated rabbit lungs in which constant blood flow infusion was carried out principally in zone 3. The liquid filtration rate (LFR) and the mean pressure of the pulmonary artery were measured.


RESULTS
A constant increase of mean pressure of the pulmonary artery was observed following the infusion (from 12.32 +/- 3.66 cm of H2O to 39.92 +/- 07.68 cmH2O (p < 0.01) which was associated to a significant increase in the rate of liquid filtration (from 0.018 +/- 0.01 g/min to 0.198 +/- 0.04 g/min; p < 0.01).


CONCLUSIONS
The administration of Intralipid produces a statistically significant increase of mean pressure of the pulmonary artery and the rate of liquid filtration. This is probably caused by vasoconstriction due to metabolic changes produced by Intralipid on pulmonary circulation.
Pozo-Parilli
J C
JC
Unidad de Fisiología Respiratoria, Instituto de Medicina Experimental, Facultad de Medicina, Venezuela.
Pinto-Plata
V M
VM
Martínez-Ruiz
R
R
Guevara
M E
ME
Sánchez de León
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002199:Capillary Permeability / Q000187:drug effects / Q000502:physiology; D005110:Extracellular Space / Q000187:drug effects* / Q000502:physiology; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits
D005217:Fat Emulsions, Intravenous