The difference in miscarriage rates between menotropin-induced and natural cycle pregnancies is not surveillance related.
OBJECTIVE
To assess the reportedly higher miscarriage rate during menotropin-induced cycle pregnancies as compared with natural cycle.


METHODS
Prospective cohort groups were selected, and pregnancies were identified 16 to 18 days after insemination and followed through to outcome.


METHODS
Three hundred twelve patients were studied: 251 women receiving human menopausal gonadotropin and 61 requiring donor insemination without medication.


RESULTS
A significant difference between the spontaneous abortion rate of gonadotropin-treated women (28.5%) and women conceiving during natural cycles (11.7%) was demonstrated.


CONCLUSIONS
The opinion that higher miscarriage rates in menotropin-treated women are related to a surveillance bias compared with natural cycle conceptions should be reconsidered.
Ransom
M X
MX
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick.
Bohrer
M
M
Blotner
M B
MB
Kemmann
E
E
D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008423:Maternal Age; D008596:Menotropins / Q000494:pharmacology*; D008597:Menstrual Cycle / Q000187:drug effects*; D011247:Pregnancy
D008596:Menotropins