[Ischemic cerebrovascular accidents in homozygous sickle cell anemia. Two case reports].
Two cases of ischemic stroke in children of Tunisian descent with sickle cell anemia are reported. Patients were aged 3 years and 14 years, respectively. Periodic partial exchange transfusions with sedimented red blood cells of identical phenotype prevented further episodes of ischemic stroke. Transplantation of HLA-identical bone marrow from a family member offers a chance of complete cure of the hemoglobin disorder in these children who are at risk of recurrent stroke.
Mbonda
E
E
Département de Pédiatrie, Centre Universitaire des Sciences de la Santé, Yaounde, Cameroun.
Thuret
I
I
Pinsard
N
N
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics; D016026:Bone Marrow Transplantation; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D002675:Child, Preschool; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D014057:Tomography, X-Ray Computed