Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis.
Fucoxanthin was shown to inhibit chemical carcinogenesis. Fucoxanthin is a natural carotenoid prepared from brown algae which is an ingredient used daily in Japanese food. In this study, all mice were given 0.01% N-ethyl-N'-nitro-N-nitrosoguanidine in their drinking water for 4 weeks. This was followed by 0.005% fucoxanthin in dimethylsulfoxide or the vehicle alone in the drinking water. In the 16-week fucoxanthin-treated group both the percentage of tumor-bearing mice and the average number of tumors per mouse were significantly lower than those of the control group. The results indicate that fucoxanthin inhibited duodenal carcinogenesis induced by N-ethyl-N'-nitro-N-nitrosoguanidine in mice.
Okuzumi
J
J
1st Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Yamane
T
T
Kitao
Y
Y
Inagake
M
M
Ohya
K
K
Nishino
H
H
Tanaka
Y
Y
D000818:Animals; D001835:Body Weight; D002273:Carcinogens; D002338:Carotenoids / Q000031:analogs & derivatives* / Q000494:pharmacology; D004379:Duodenal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives; D051379:Mice; D024341:Xanthophylls
D002273:Carcinogens; D024341:Xanthophylls; C025164:fucoxanthin; D008769:Methylnitronitrosoguanidine; D002338:Carotenoids; C013525:ENNG