Peripheral expansion of gamma delta T cell receptor-positive cells in a patient with Crohn's disease.
A 13 year old boy with Crohn's disease had a prominent expansion (over 40%) of gamma delta T cell receptor-positive cells (gamma delta T cells) in the peripheral blood. The gamma delta T cells were gradually decreased from 48 to 22% in 18 months. Anti-gamma delta T cell receptor-triggered cytotoxicity was evident at onset and after 1 year. The significance of peripheral expansion of gamma delta T cells in a patient with Crohn's disease is discussed.
Hara
T
T
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Matsumoto
T
T
Mizuno
Y
Y
Nishizaki
M
M
Ueda
K
K
Motooka
M
M
Kimura
N
N
Oshimi
K
K
Ohga
S
S
Yoshikai
Y
Y
D000293:Adolescent; D003424:Crohn Disease / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta