Renin and prorenin in reproductive tissues during gestation in pigs and cattle.
1. High concentrations of prorenin and active renin were previously found in ovarian follicular fluid from cattle but not from pigs. In the present study female reproductive tissues and fluids from cattle and pigs during gestation were investigated to clarify a possible species difference in active renin and prorenin concentrations. 2. Very high concentrations of active renin but no prorenin were found in corpus luteum from both species. 3. Relatively low concentrations of active renin, in the same order as in maternal blood plasma, were found in myometrium, endometrium, placenta and fetal membranes from both species. Prorenin was undetectable in these tissues except for bovine myometrium and porcine endometrium in some animals. 4. The concentrations of active renin and prorenin in amnionic fluid from both species were below the maternal plasma values. In allantoic fluid the concentrations were higher than in amnionic fluid. 5. The plasma concentrations of active renin and prorenin did not change during gestation in pigs. This finding is in contrast to the observations in humans and does not support a systemic effect of prorenin during gestation. 6. The presence of renin in the reproductive tissues, especially the very high concentrations in the corpus luteum, indicates a local function of the renin-angiotensin system during gestation.
Hagemann
A
A
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Dantzer
V
V
Nielsen
A H
AH
Poulsen
K
K
D000482:Allantois / Q000378:metabolism; D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000378:metabolism; D004792:Enzyme Precursors / Q000097:blood / Q000378:metabolism*; D005321:Extraembryonic Membranes / Q000378:metabolism; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000378:metabolism*; D012083:Renin / Q000097:blood / Q000378:metabolism*; D013045:Species Specificity; D013552:Swine; D014599:Uterus / Q000378:metabolism
D004792:Enzyme Precursors; D012083:Renin