Different clearance of intravenously administered olive oil and soybean-oil emulsions: role of hepatic lipase.
The elimination of two intravenously administered fat emulsions consisting of either 20% (wt:vol) soybean oil or 17% olive oil plus 3% soybean oil was studied in six normolipidemic young men according to a randomized crossover protocol. Slower elimination was found with the olive oil emulsion. A significantly lower maximal removal capacity (K1) and fractional catabolic rate (K2) were measured with olive oil emulsion (P < 0.05). Removal of olive oil emulsion was inversely related to hepatic lipase activity (r = -0.85; P < 0.05). Removal of soybean-oil emulsion was related to the initial plasma triglyceride concentration (r = -0.84; P < 0.05) but not to lipolytic activity. In vivo apolipoprotein C-II binding was similar for both emulsions. Therefore, hepatic lipase activity is more important in the elimination of olive oil emulsions than soybean-oil emulsions. The faster elimination of soybean-oil emulsions suggests an additional elimination pathway, such as the reticuloendothelial system.
Brouwer
C B
CB
Department of Endocrinology, University Hospital, Rotterdam, The Netherlands.
de Bruin
T W
TW
Jansen
H
H
Erkelens
D W
DW
D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008049:Lipase / Q000502:physiology; D008099:Liver / Q000201:enzymology; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D009391:Nephelometry and Turbidimetry; D000069463:Olive Oil; D010743:Phospholipids / Q000097:blood; D010938:Plant Oils / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013024:Soybean Oil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D005217:Fat Emulsions, Intravenous; D000069463:Olive Oil; D010743:Phospholipids; D010938:Plant Oils; D014280:Triglycerides; D013024:Soybean Oil; D002784:Cholesterol; D008049:Lipase