Immunopathology of alkaline phosphatase isozymes in seminoma.
An immunohistopathological study using monoclonal antibodies for alkaline phosphatases demonstrated placental alkaline phosphatase (PLAP)-like substance in the tumor cells of 11 pure seminomas, 1 seminoma with embryonal carcinoma and 1 seminoma metastasis. Liver alkaline phosphatase (LAP) could also be demonstrated in all seminomas but a third intestinal alkaline phosphatase (IAP) was not demonstrable in any tumor. The PLAP-like substance and LAP had considerable enzyme activities. This provides two tumor markers of seminomas detectable in histopathological specimens.
Yamamoto
H
H
Department of Urology, Kanazawa University, Japan.
Uchibayashi
T
T
Koshida
K
K
Hirano
K
K
Hisazumi
H
H
D000469:Alkaline Phosphatase / Q000032:analysis*; D004407:Dysgerminoma / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D007422:Intestines / Q000201:enzymology; D007527:Isoenzymes / Q000032:analysis*; D008099:Liver / Q000201:enzymology; D008297:Male; D010920:Placenta / Q000201:enzymology; D013736:Testicular Neoplasms / Q000201:enzymology*
D007527:Isoenzymes; D000469:Alkaline Phosphatase