Transient hyperemia succeeds oligemia in the wake of cortical spreading depression.
Regional cerebral blood flow (rCBF) was examined following single episodes of cortical spreading depression (CSD) in rat brain after an intravenous bolus injection of [14C]iodoantipyrine. Cortical rCBF decreased to approximately 75% of control values during the first 60 min after CSD. This change was succeeded at 90-105 min by a small, transient flow increase. rCBF returned to normal at 120 min after CSD, and remained normal for the following 2 h. The same sequence of rCBF changes has been recorded in patients during migraine attacks. This study therefore supports the notion that CSD may serve as an animal model of migraine.
Fabricius
M
M
Department of General Physiology and Biophysics, University of Copenhagen, Denmark.
Lauritzen
M
M
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D013181:Cortical Spreading Depression / Q000502:physiology*; D004594:Electrophysiology; D005947:Glucose / Q000378:metabolism; D006940:Hyperemia / Q000503:physiopathology*; D008297:Male; D008839:Microelectrodes; D010101:Oxygen Consumption / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D005947:Glucose