Two color flow cytometric analysis of lymphocytes in HTLV-I carrier children.
Phenotypic changes in lymphocytes from healthy children with antibody for human T lymphotrophic virus type I (HTLV-I) were studied using two color flow cytometry. The subjects were high school students within a small district of Kyushu, Japan. In the carrier group, a subset of lymphocytes which expressed CD8+CD57+ was significantly lower in percentage (P < 0.01) and in number (P < 0.05). There was no significant difference between carriers and non-carriers in the percentage and number of CD4+Leu8+ cells or CD4+HLA-DR+ cells. The IgG levels were slightly higher in carriers than in non-carriers (P < 0.05). These findings suggest that HTLV-I-infected cells may affect the immune system in healthy carrier children.
Sato
T
T
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Yanagisawa
M
M
Muchi
H
H
D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000276:immunology*; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D015490:HTLV-I Infections / Q000276:immunology*; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male