title: Is serum anhydroglucitol an alternative to the oral glucose tolerance test for diabetes screening? The Mauritius Noncommunicable Diseases Study Group.
abstract: The oral glucose tolerance test is inconvenient for diabetes screening. In clinical studies a reduced serum anhydroglucitol level has proved to be a sensitive and specific test for diabetes. A new minicolumn enzymatic method which is simple and robust makes use in population screening feasible. The aim of our study was to assess the usefulness of a single measurement of anhydroglucitol to screen for diabetes and impaired glucose tolerance. Assays were performed on samples taken from 227 Mauritian Chinese subjects at the time of glucose tolerance testing. Subjects had normal glucose tolerance (n = 82), impaired glucose tolerance (n = 76), newly diagnosed diabetes (n = 38), and known diabetes (n = 31). Anhydroglucitol concentrations (mean +/- SD) were similar for normal and impaired glucose tolerance subjects (23.7 +/- 8.2 vs 23.4 +/- 8.6 mg l-1). Although the differences between normal and newly diagnosed diabetes (15.0 +/- 11.0 mg l-1) and known diabetic subjects (11.8 +/- 10.6 mg l-1) were significant (p < 0.001), diagnostic sensitivity and specificity were poor. We conclude that measurement of serum anhydroglucitol is not suitable for screening for the diagnoses of impaired glucose tolerance and diabetes.
authors.affiliation: Human Diabetes and Metabolism Research Centre, Newcastle upon Tyne, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Robertson
authors.forename: K G
authors.initials: KG
authors.lastname: Alberti
authors.forename: G K
authors.initials: GK
authors.lastname: Dowse
authors.forename: P
authors.initials: P
authors.lastname: Zimmet
authors.forename: J
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: H
authors.initials: H
authors.lastname: Gareeboo
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D003847:Deoxyglucose / Q000097:blood*; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D019270:Fructosamine; D005951:Glucose Tolerance Test; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007536:Isomerism; D008297:Male; D008403:Mass Screening / Q000379:methods; D008436:Mauritius / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012016:Reference Values
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006595:Hexosamines; D019270:Fructosamine; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose