Polyautoimmunity in a young woman.
A young woman with the HLA phenotype A1, A2, B5, B8, DR3, DR4 developed RA, idiopathic thrombocytopenic purpura (ITP), pernicious anaemia (PA), Hashimoto's thyroiditis (HT), systemic sclerosis (SS), pancreatic exocrine insufficiency (PEI) and coeliac disease (CD) before dying from vasculitic complications. A family study revealed RA, PA and insulin-dependent diabetes mellitus (IDDM) amongst her first degree relatives. Her case emphasizes the clinical and immunogenetic links between the autoimmune diseases.
Sheehan
N J
NJ
Department of Rheumatology, Edith Cavell Hospital, Bretton Gate, Peterborough.
Stanton-King
K
K
D000328:Adult; D000752:Anemia, Pernicious / Q000150:complications / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity; D002446:Celiac Disease / Q000150:complications / Q000276:immunology; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D015994:Incidence; D010641:Phenotype; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000276:immunology; D012595:Scleroderma, Systemic / Q000150:complications / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology; D014657:Vasculitis / Q000150:complications / Q000276:immunology
D006680:HLA Antigens