title: Holzgreve syndrome: recurrence in sibs.
abstract: We report on 2 sibs with cardiac and renal abnormalities. The first had hypoplastic left heart sequence and renal hypoplasia; the second had a complex congenital heart defect, renal agenesis, and cleft lip and palate. We suggest that these cases represent the first familial examples of the Holzgreve syndrome. As such, they demonstrate the phenotypic variability seen in sibs, and may serve to further delineate the syndrome.
authors.affiliation: Department of Pediatrics, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157.
authors.forename: I T
authors.initials: IT
authors.lastname: Thomas
authors.forename: G M
authors.initials: GM
authors.lastname: Honore
authors.forename: T
authors.initials: T
authors.lastname: Jewett
authors.forename: H
authors.initials: H
authors.lastname: Velvis
authors.forename: P
authors.initials: P
authors.lastname: Garber
authors.forename: C
authors.initials: C
authors.lastname: Ruiz
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics* / Q000473:pathology; D002971:Cleft Lip / Q000235:genetics; D002972:Cleft Palate / Q000235:genetics; D005260:Female; D005333:Fetus / Q000473:pathology; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D008297:Male; D013577:Syndrome