Oral contraceptives and reproductive factors in multiple sclerosis incidence.
Data from the Oxford.FPA prospective study show that oral contraceptive use and pregnancy have no discernible effect on the risk of developing multiple sclerosis (MS). Women of parity 0-2 developed MS twice as often as women of parity 3 or more but the difference did not reach statistical significance. Smoking may be a risk factor for developing MS. A nested case-control analysis did not identify any associations between MS onset and preceding illnesses.
Villard-Mackintosh
L
L
Department of Public Health and Primary Care, Radcliffe Infirmary, Oxford, England.
Vessey
M P
MP
D000328:Adult; D000367:Age Factors; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005193:Family Planning Services; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D010298:Parity / Q000502:physiology*; D011247:Pregnancy / Q000502:physiology*; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D003276:Contraceptives, Oral