Mathematical modelling of the human cardiovascular system in the presence of stenosis.
This paper reports a theoretical study on the distribution of blood flow in the human cardiovascular system when one or more blood vessels are affected by stenosis. The analysis employs a mathematical model of the entire system based on the finite element method. The arterial-venous network is represented by a large number of interconnected segments in the model. Values for the model parameters are based upon the published data on the physiological and rheological properties of blood. Computational results show how blood flow through various parts of the cardiovascular system is affected by stenosis in different blood vessels. No significant changes in the flow parameters of the cardiovascular system were found to occur when the reduction in the lumen diameter of the stenosed vessels was less than 65%.
Sud
V K
VK
Biophysics Department, All India Institute of Medical Sciences, New Delhi.
Srinivasan
R S
RS
Charles
J B
JB
Bungo
M W
MW
D001775:Blood Circulation / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D003251:Constriction, Pathologic / Q000503:physiopathology; D006801:Humans; D008433:Mathematics; D008955:Models, Cardiovascular