title: Cortisol levels in children with haemoglobinopathies in north Jordan.
abstract: Serum cortisol levels of 100 children 3-10 years old with various haemoglobinopathies were measured. The mean cortisol levels of sickle cell trait, sickle cell disease, beta-thalassemia minor and alpha 2-thalassemia were significantly (P < 0.05) lower than those of normal subjects. The decrease in cortisol levels varied from 25 (in the sickle cell trait group) to 57 per cent (in the alpha 2-thalassemia group) of the mean cortisol levels of the control group. These results suggest the presence of hypoadrenalism and its possible association with the indicated haemoglobinopathies.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid-Jordan.
authors.forename: N
authors.initials: N
authors.lastname: Bashir
authors.forename: A F
authors.initials: AF
authors.lastname: al-Hader
authors.forename: L
authors.initials: L
authors.lastname: al-Shareef
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006453:Hemoglobinopathies / Q000097:blood* / Q000145:classification / Q000453:epidemiology; D006784:Hospitals, Teaching; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007597:Jordan / Q000453:epidemiology; D008297:Male; D010044:Outpatient Clinics, Hospital
chemical_list: D006854:Hydrocortisone