Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25-->p24.
Thyroid peroxidase (TPO), the enzyme responsible for thyroid hormone synthesis, is a key autoantigen in autoimmune thyroid disease. Based on the results of a study using both isotopic and nonisotopic in situ hybridization, we assign the gene coding for human TPO to chromosome region 2p25-->p24.
Barnett
P S
PS
Department of Medicine, King's College School of Medicine and Dentistry, London, UK.
Jones
T A
TA
McGregor
A M
AM
Banga
J P
JP
Sheer
D
D
D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D015342:DNA Probes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007453:Iodide Peroxidase / Q000235:genetics*
D015342:DNA Probes; D007453:Iodide Peroxidase