The effects of liver and renal disease on stereoselective serum binding of flurbiprofen.
Stereoselectivity in the serum binding of flurbiprofen, a non-steroidal anti-inflammatory drug which is highly bound to albumin, was studied in patients with liver and renal disease. Subjects with renal disease or liver disease with ascites had significantly lower serum albumin concentrations than normals, resulting in higher free fractions of both the R(-) and S(+) enantiomers of flurbiprofen as determined by equilibrium dialysis. The ratio (+/- s.d.) of R/S-flurbiprofen free fractions was lower in the subjects with ascites (0.714 +/- 0.298) than in those without ascites (0.796 +/- 0.090) (P < 0.05).
Blouin
R
R
College of Pharmacy, University of Kentucky, Lexington 40536-0082.
Chaudhary
I
I
Nishihara
K
K
Cox
S
S
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism*; D005480:Flurbiprofen / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D013237:Stereoisomerism
D001798:Blood Proteins; D005480:Flurbiprofen