title: Methazolamide-induced skin eruptions.
abstract: To our knowledge, this is the first histopathologic report of skin eruptions due to oral methazolamide. From the four cases studied, we conclude that there are at least two histopathologic types: one is characterized by perivascular lymphocytic infiltrate with a vacuolar alteration at the dermoepidermal junction, the other by perivascular eosinophils, lymphocytes, and scattered mast cells. There also seem to be at least two patterns of skin eruptions: one maculopapular and the other urticarial. The type of skin eruption and the histopathologic type appear to be related.
authors.affiliation: Glaucoma Service, Wills Eye Hospital, Philadelphia, Pa.
authors.forename: S B
authors.initials: SB
authors.lastname: Gandham
authors.forename: G L
authors.initials: GL
authors.lastname: Spaeth
authors.forename: M
authors.initials: M
authors.lastname: Di Leonardo
authors.forename: V P
authors.initials: VP
authors.lastname: Costa
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D008704:Methazolamide / Q000009:adverse effects* / Q000627:therapeutic use; D014581:Urticaria / Q000139:chemically induced / Q000473:pathology
chemical_list: D008704:Methazolamide