title: Effect of 131I treatment on the calcitonin response to calcium infusion in hyperthyroid patients.
abstract: OBJECTIVE
  The objective was to evaluate the effect of 131I treatment for hyperthyroidism on calcitonin secretion by thyroid C-cells.
  
  
  METHODS
  Determination of basal calcitonin levels and calcitonin secretory reserve before and after 131I administration.
  
  
  METHODS
  Seventeen hyperthyroid patients (15 female, two male) were studied before, and 2 months after 131I treatment, and 12 of these patients were restudied 8 months after 131I treatment.
  
  
  METHODS
  Calcitonin response was assessed by measuring basal and post calcium infusion calcitonin levels. Basal TSH, T3, and T4 levels were also determined at each study.
  
  
  RESULTS
  The rise of plasma calcium resulted in statistically significant increase of plasma calcitonin levels before 131I treatment (10.9 +/- 2.4 pmol/l), while this response was significantly diminished 2 and 8 months after treatment (2.6 +/- 0.7 and 1.6 +/- 0.3 pmol/l, respectively). No correlation was found between the calcitonin response and age or plasma TSH.
  
  
  CONCLUSIONS
  Our results demonstrate that 131I treatment for hyperthyroidism may seriously damage thyroid C-cells and cause calcitonin deficiency.
authors.affiliation: Department of Endocrinology, Evangelismos Hospital, Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Tzanela
authors.forename: N C
authors.initials: NC
authors.lastname: Thalassinos
authors.forename: A
authors.initials: A
authors.lastname: Nikou
authors.forename: G
authors.initials: G
authors.lastname: Georgiadis
authors.forename: D
authors.initials: D
authors.lastname: Philokiprou
mesh_terms: D000328:Adult; D000368:Aged; D002116:Calcitonin / Q000097:blood / Q000378:metabolism*; D002118:Calcium / Q000008:administration & dosage / Q000097:blood; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000532:radiotherapy*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism* / Q000528:radiation effects
chemical_list: D007457:Iodine Radioisotopes; D002116:Calcitonin; D002118:Calcium