Generalised giant-cell tumour of bone: successful treatment of pulmonary metastases with interferon alpha, a case report.
We report on a 37-year-old female patient with generalised giant-cell tumour of the bone, whose tumour was refractory to conventional chemotherapy. Subsequent treatment with interferon alpha 2a in increasing dosage from 4 x 10(6) IU (three times a week) to 9 x 10(6) IU (three times a week) led to a significant decrease of pulmonary metastases and a stabilisation of the disease after 12 months of treatment. In progressive chemotherapy refractory giant-cell tumour interferon alpha 2a may be of therapeutic benefit.
Kaiser
U
U
Philipps-Universität Marburg, Zentrum für Innere Medizin, Abteilung Hämatologie/Onkologie, Marburg, Federal Republic of Germany.
Neumann
K
K
Havemann
K
K
D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005870:Giant Cell Tumors / Q000188:drug therapy* / Q000556:secondary*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins