Prevention of galactosamine-induced hepatic damage by picroliv: study on bile flow and isolated hepatocytes (ex vivo).
Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3-12 mg/kg p.o. x 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the percentage of viability of hepatocytes. It also restored the galactosamine-induced changes in the levels of enzymes (GOT, GPT and alkaline phosphatase) both in isolated hepatic cells as well as in serum. In addition, picroliv possessed a marked anticholestatic effect. Picroliv was found to be more potent than silymarin, a standard hepatoprotective agent.
Visen
P K
PK
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow, India.
Shukla
B
B
Patnaik
G K
GK
Dhawan
B N
BN
D000818:Animals; D001646:Bile / Q000187:drug effects*; D056486:Chemical and Drug Induced Liver Injury; D002934:Cinnamates / Q000494:pharmacology*; D005260:Female; D005688:Galactosamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012838:Silymarin / Q000494:pharmacology; D014641:Vanillic Acid / Q000494:pharmacology*
D002934:Cinnamates; D006027:Glycosides; D010936:Plant Extracts; D012838:Silymarin; C057463:kutkin; D005688:Galactosamine; D014641:Vanillic Acid