title: The relationship of arterial compliance with endothelial-derived proteins of the hemostatic system.
abstract: Cardiovascular risk factors associated with hypertension include alterations in arterial compliance and an increased tendency to thrombosis. In this study we examined the relationship between arterial compliance and endothelial derived components of the hemostatic system: von Willebrand factor (vWF) and tissue plasminogen activator (t-PA). Ten males (4 normal and 6 untreated hypertensives, 41 +/- 12 years) were studied. Compliance of proximal (large vessel) and distal (small vessel) arteries was measured by intraarterial pulse wave analysis; left ventricular wall thickness by echocardiography; and vWF and t-PA by immunoassay of plasma obtained before and immediately after maximum treadmill exercise. Baseline t-PA and vWF correlated inversely with distal compliance (r = -0.74, p = 0.01; r = -0.56, p = 0.09). Exercise strengthened the relationship between vWF and both distal compliance (r = -0.56 to r = -0.86) and proximal compliance (r = -0.44 to r = -0.70). Moreover, post-exercise levels of vWF and t-PA were each significantly related to left ventricular posterior wall and septal thickness. Of note, these protein concentrations correlated more strongly with arterial compliance and left ventricular wall thickness than with blood pressure. Thus, arterial compliance and left ventricular wall thickness appear to be more powerful than blood pressure as predictors of the endothelial release of vWF and t-PA in response to exercise. These findings indicate that some of the key cardiac and arterial characteristics of hypertension might be linked to increased endothelial reactivity to hemodynamic stress.
authors.affiliation: Hypertension Center, Veterans Affairs Medical Center, Long Beach, California 90822.
authors.forename: D H
authors.initials: DH
authors.lastname: Smith
authors.forename: N D
authors.initials: ND
authors.lastname: Vaziri
authors.forename: R L
authors.initials: RL
authors.lastname: Winer
authors.forename: J M
authors.initials: JM
authors.lastname: Neutel
authors.forename: W F
authors.initials: WF
authors.lastname: Graettinger
authors.forename: E
authors.initials: E
authors.lastname: Gonzales
authors.forename: M A
authors.initials: MA
authors.lastname: Weber
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001916:Brachial Artery / Q000502:physiology* / Q000503:physiopathology; D004452:Echocardiography; D006339:Heart Rate; D006487:Hemostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000502:physiology* / Q000503:physiopathology; D005082:Physical Exertion; D011674:Pulse; D012016:Reference Values; D010959:Tissue Plasminogen Activator / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor; D010959:Tissue Plasminogen Activator