Changes in hepatic vitamin K1 levels after prophylactic administration to the newborn.
We undertook a study of hepatic concentrations of vitamin K (vitamin K1 or phylloquinone, vitamin K1-epoxide, and menaquinones) in 18 infants, ages 1-8 days, with or without vitamin K1 supplementation. The infants who had no supplementation had a total hepatic storage ranging between 0.1 and 0.9 micrograms. Also, hepatic storage of phylloquinone was poor (< 1 microgram) when compared with daily requirements. Moreover, we did not detect any menaquinone in the livers of these infants in our study. The prophylaxis applied to the other infants was very efficient. Hepatic vitamin K1 concentrations, obtained < 24 h after administration, were very high (62.8-93.5 micrograms/g). Vitamin K1-epoxide concentrations were high, which proved the efficiency of the vitamin K cycle. In contrast, the decrease in vitamin K1 concentrations was also very rapid, since the median value after 48 h was 8.4 micrograms/g and only 2.9 micrograms/g 5 days after administration. However, hepatic total storage after 5 days in one infant with vitamin K1 supplementation was much higher (112 micrograms) than in infants who had not received supplementation. In conclusion, hepatic phylloquinone storage at birth was poor (< 1 microgram). The newborn infant might be in a situation of potential deficiency. After prophylactic oral administration of phylloquinone, uptake by the liver was quite satisfactory, but concentrations dropped quickly. However, phylloquinone hepatic storage remained elevated (112 micrograms) after 5 days.
Guillaumont
M
M
Laboratory of Clinical Pharmacology, Hôpital Debrousse, Lyon, France.
Sann
L
L
Leclercq
M
M
Dostalova
L
L
Vignal
B
B
Frederich
A
A
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000378:metabolism*; D014812:Vitamin K / Q000378:metabolism; D010837:Vitamin K 1 / Q000031:analogs & derivatives / Q000378:metabolism / Q000493:pharmacokinetics*
D014812:Vitamin K; C016186:vitamin K1 oxide; D010837:Vitamin K 1