title: Metronidazole in the treatment of localized juvenile periodontitis.
abstract: Systemic metronidazole and tetracycline were compared as adjunctive agents in the treatment of localized juvenile periodontitis (LJP). 27 patients with Actinobacillus actinomycetemcomitans-positive (Aa) LJP were treated with scaling and rootplaning, control of oral hygiene and periodontal surgery if indicated. The patients were randomly divided into 3 equal groups: the 1st group had metronidazole 200 mg x 3 x 10 days, the 2nd tetracycline 250 mg x 4 x 12 days, the 3rd group received no medication and served as a control. 6 patients had periodontal surgery. 4 sites with the most advanced bone loss as determined on radiographs were selected in each subject for test sites. Gingival index, gingival bleeding after probing (GB), probing depth (PD), suppuration, and radiographic bone loss were registered, and subgingival Aa was selectively cultured. GB and PD > or = 4 mm were registered in the whole dentition as well. All parameters were monitored at baseline and at 6 and 18 months after treatment. By the end of the study, Aa was suppressed to below detection level at all test sites only in the metronidazole group, at 17/26 sites (4 patients) in the tetracycline group and at 19/26 sites (6 patients) in the control group. Clinically, all groups showed improvement. In conclusion, metronidazole was more effective than tetracycline in the suppression of Aa and the suppression of Aa appeared to produce better clinical results.
authors.affiliation: Department of Periodontology, University of Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Saxén
authors.forename: S
authors.initials: S
authors.lastname: Asikainen
mesh_terms: D000293:Adolescent; D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects / Q000302:isolation & purification; D010520:Aggressive Periodontitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000517:prevention & control; D003773:Dental Plaque / Q000382:microbiology; D005260:Female; D005884:Gingival Hemorrhage / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D011859:Radiography; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D008795:Metronidazole; D013752:Tetracycline