Growth factors in nutritional support.
Protein catabolism occurs in the severely stressed patient despite adequate protein supplementation. Supplementation of endogenous growth factors is one mechanism being evaluated to promote anabolism and improve nitrogen retention. Recombinant technology has provided a means to reproduce these endogenous growth factors. Both recombinant human growth hormone (rGH) and recombinant human insulin-like growth factor-1 (rhlGf-1) are undergoing clinical trials to establish their roles in nutritional support.
Hatton
J
J
Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington 40536-0082.
Luer
M S
MS
Rapp
R P
RP
D006133:Growth Substances / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology* / Q000502:physiology; D009748:Nutrition Disorders / Q000378:metabolism / Q000628:therapy; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D011994:Recombinant Proteins; D013312:Stress, Physiological / Q000378:metabolism*
D006133:Growth Substances; D011506:Proteins; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I