Disseminated atypical blastomycosis in two patients with AIDS.
Two men with AIDS developed fungal infections and subsequently died as a result of dissemination of the fungal infection. Findings obtained by histologic examination, serological studies, and cultures suggested that the infections were caused by Blastomyces dermatitidis. Tissue sections showed polymorphic yeast-like cells 5-20 microns in diameter (some with broad and others with narrow single- or multiple-based buds), small yeasts, and hyphal elements. The exoantigen K positivity and exoantigen A negativity of one of the isolates indicated that the fungus was more like an African than a North American serotype.
Tan
G
G
Department of Pathology, University of California, Irvine, Orange 92668.
Kaufman
L
L
Peterson
E M
EM
de la Maza
L M
LM
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000328:Adult; D000946:Antigens, Fungal / Q000032:analysis; D001758:Blastomyces / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D001759:Blastomycosis / Q000382:microbiology*; D006801:Humans; D008168:Lung / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000382:microbiology; D008297:Male
D000946:Antigens, Fungal