title: Results of salvage mastectomy for local recurrence after breast-conserving surgery without radiation therapy.
abstract: BACKGROUND
  Between 1975 and 1987, 128 patients with infiltrating breast cancer, categorized as clinical Stage I and II disease, were treated by breast conservation surgery without radiation therapy.
  
  
  METHODS
  After a median disease-free interval of 20 months (range, 8-64 months), 25 of 128 patients had local recurrence, for which salvage mastectomy was performed. The results of modified radial mastectomy as a salvage procedure were analyzed in these 25 patients.
  
  
  RESULTS
  After a median disease-free interval of 52 months (range, 8-75 years) after the salvage procedure, 12 patients had chest wall and distant recurrences, whereas 13 patients remained free of disease. The 5-year actuarial disease-free and overall survival rates after the salvage mastectomy were 51% and 65%, respectively.
  
  
  CONCLUSIONS
  Univariate analyses of factors affecting disease-free survival and overall survival showed that the size of the local recurrence (< or = 2 cm) (P = 0.009) and the number of pathologically positive axillary nodes at the time of the salvage procedure (fewer than four nodes) (P = 0.002) were associated with a better prognosis.
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263.
authors.forename: C C
authors.initials: CC
authors.lastname: Cajucom
authors.forename: T N
authors.initials: TN
authors.lastname: Tsangaris
authors.forename: T
authors.initials: T
authors.lastname: Nemoto
authors.forename: D
authors.initials: D
authors.lastname: Driscoll
authors.forename: R B
authors.initials: RB
authors.lastname: Penetrante
authors.forename: E D
authors.initials: ED
authors.lastname: Holyoke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D015411:Mastectomy, Modified Radical / Q000401:mortality; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011379:Prognosis; D011878:Radiotherapy; D016879:Salvage Therapy; D015996:Survival Rate