title: Neoplastic association of enhanced type V collagen production in rat fibrosarcoma.
abstract: Collagens present in the connective tissues of the extracellular matrix of fibrosarcoma were isolated and characterized. The fibrosarcoma was induced in rats by the administration of 3-methylcholanthrene. The results obtained were compared with normal muscle. An excess amount of type V collagen was found to be produced by the fibrosarcoma tissue compared to the normal muscle. Type V collagen from fibrosarcoma was characterized on the basis of solubility behavior in sodium chloride solutions, electrophoretic mobility on SDS-polyacrylamide gels, elution pattern of phosphocellulose chromatography and amino acid composition.
authors.affiliation: Department of Biochemistry, Central Leather Research Institute, Madras, India.
authors.forename: R
authors.initials: R
authors.lastname: Asokan
authors.forename: G K
authors.initials: GK
authors.lastname: Reddy
authors.forename: S C
authors.initials: SC
authors.lastname: Dhar
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002850:Chromatography, Gel; D003094:Collagen / Q000096:biosynthesis* / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005109:Extracellular Matrix / Q000378:metabolism; D005354:Fibrosarcoma / Q000139:chemically induced / Q000378:metabolism*; D008748:Methylcholanthrene; D009132:Muscles / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000596:Amino Acids; D008748:Methylcholanthrene; D003094:Collagen