title: Assay of certain oral contraceptive formulations by gas chromatography-mass spectrometry-selected ion monitoring.
abstract: The combined technique of gas chromatography--mass spectrometry--selected ion monitoring (GC-MS-SIM) has been employed for the nanogram level determination of ethinyloestradiol, mestranol, norgestrel and norethisterone in various oral contraceptive formulations. Steroids were assayed as their DMES-or methoxime DMES ether derivatives in the presence of ethisterone as the internal standard. The method is accurate, specific and suitable for single tablet assay.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
authors.forename: C J
authors.initials: CJ
authors.lastname: Brooks
authors.forename: M I
authors.initials: MI
authors.lastname: Walash
authors.forename: M
authors.initials: M
authors.lastname: Rizk
authors.forename: N A
authors.initials: NA
authors.lastname: Zakhari
authors.forename: S S
authors.initials: SS
authors.lastname: Toubar
authors.forename: D G
authors.initials: DG
authors.lastname: Watson
mesh_terms: D003278:Contraceptives, Oral, Hormonal / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods
chemical_list: D003278:Contraceptives, Oral, Hormonal