title: Metformin and liver glycogen synthase activity in obese Zucker rats.
abstract: The effect of chronic treatment with metformin (320 mg/kg/day) on plasma glucose and insulin as well as liver glycogen synthase activity and hepatic glycogen content was studied in obese hyperinsulinemic Zucker rats. Metformin significantly reduced both plasma glucose (by 10%) and insulin levels (by 39%) at fasting but had no effect on hepatic glycogen content or on the basal activity of liver glycogen synthase.
authors.affiliation: Department of Clinical Pharmacology, University of Turku, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Huupponen
authors.forename: K
authors.initials: K
authors.lastname: Pyykkö
authors.forename: M
authors.initials: M
authors.lastname: Koulu
authors.forename: J
authors.initials: J
authors.lastname: Rouru
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism*; D006946:Hyperinsulinism / Q000188:drug therapy / Q000201:enzymology*; D007333:Insulin Resistance; D008099:Liver / Q000201:enzymology*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D009765:Obesity / Q000201:enzymology*; D051381:Rats; D011924:Rats, Zucker
chemical_list: D001786:Blood Glucose; D008112:Liver Glycogen; D008687:Metformin; D006006:Glycogen Synthase