Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L.
Scopadulcic acid B (SDB), a tetracyclic diterpenoid isolated from a medicinal plant, Scoparia dulcis L., inhibited the effects of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro and in vivo; SDB inhibited TPA-enhanced phospholipid synthesis in cultured cells, and also suppressed the promoting effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. The potency of SDB proved to be stronger than that of other natural antitumor-promoting terpenoids, such as glycyrrhetinic acid.
Nishino
H
H
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Hayashi
T
T
Arisawa
M
M
Satomi
Y
Y
Iwashima
A
A
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D004224:Diterpenes / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D004224:Diterpenes; D010743:Phospholipids; C058658:scopadulcic acid B; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate