Pharmacokinetics of doxycycline after parenteral administration in the Houbara bustard (Chlamydotis undulata).
Fourteen adult Houbara bustards (Chlamydotis undulata) infected with Chlamydia psittaci were administered doxycycline at 100 mg/kg body weight in seven intramuscular or subcutaneous injections at intervals of 7, 7, 7, 6, 6, and 5 days. Blood levels of doxycycline were measured after the first and seventh injections at the following intervals: 0, 12, 24, 36, 48, 72, 96, 120, 144, 168, and 180 hours. During these two periods, most of the birds showed plasma doxycycline levels in excess of 1 micrograms/ml, demonstrating effective doxycycline levels for 45 days. A multifactorial analysis of variance revealed no significant differences between males and females, between the two routes of administration, or among all four factors.
Greth
A
A
National Wildlife Research Center, (National Commission for Wildlife Conservation and Development), Taif, Saudi Arabia.
Gerlach
H
H
Gerbermann
H
H
Vassart
M
M
Richez
P
P
D000818:Animals; D001715:Bird Diseases / Q000188:drug therapy*; D001717:Birds; D004318:Doxycycline / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D007263:Infusions, Parenteral / Q000662:veterinary; D008297:Male; D009956:Psittacosis / Q000188:drug therapy / Q000662:veterinary*
D004318:Doxycycline