title: Steroid-responsive sensorineural hearing loss: combination therapy with prednisolone and Sairei-to.
abstract: We observed cases of hearing loss in which hearing deteriorated when steroid therapy was discontinued and improved upon re-administration. We identified these as cases of steroid-responsive sensorineural hearing loss (SNHL). The diagnostic criteria for determining steroid-responsive SNHL were stated, and 10 cases were examined. The 10 cases of steroid-responsive SNHL were divided into two groups: 3 cases associated with aortitis syndrome (systemic type) and 7 cases with no known systemic disease (localized type). Relatively satisfactory hearing was maintained in these cases by long-term oral administration of prednisolone (PSL). The combined use of Sairei-to made it possible to decrease the necessary maintenance dose of PSL. While the pathology of steroid-responsive SNHL is still unclear, it is suspected that immune complex disease or vasculitis may be involved.
authors.affiliation: Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kanzaki
authors.forename: T
authors.initials: T
authors.lastname: O-uchi
authors.forename: N
authors.initials: N
authors.lastname: Tsuchihashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001015:Aortic Arch Syndromes / Q000150:complications; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D011239:Prednisolone