Effects of interleukin-8 on nonspecific resistance to infection in neutropenic and normal mice.
The effect of treatment with interleukin-8 (IL-8), a neutrophil-activating cytokine, was investigated in normal and neutropenic mice infected with a lethal dose of Pseudomonas aeruginosa, Klebsiella pneumoniae, or Plasmodium berghei. Intraperitoneal (i.p.) IL-8 treatment was associated with accelerated death when IL-8 was administered shortly before i.p. infection with P. aeruginosa or shortly after i.p. infection with P. aeruginosa and K. pneumoniae. Histopathological analyses demonstrated a tendency to more severe organ lesions in IL-8-treated mice. Only nonneutropenic mice that received IL-8 shortly before the infectious challenge and at the site of infection were protected by IL-8. Whether IL-8 is protective of or detrimental to the survival of infection appeared to depend on the presence of bacteria at the injection site and on the presence of neutropenia. IL-8 may be an important participant in the cascade of interacting cytokines that is induced by the lethal infectious challenge.
Vogels
M T
MT
Department of Medicine, University Hospital, Nijmegen, The Netherlands.
Lindley
I J
IJ
Curfs
J H
JH
Eling
W M
WM
van der Meer
J W
JW
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D001921:Brain / Q000382:microbiology / Q000473:pathology; D005260:Female; D016209:Interleukin-8 / Q000494:pharmacology*; D007710:Klebsiella Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D007711:Klebsiella pneumoniae; D007958:Leukocyte Count; D008288:Malaria / Q000276:immunology; D051379:Mice; D009503:Neutropenia / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D010962:Plasmodium berghei; D011552:Pseudomonas Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control
D016209:Interleukin-8