Synthesis and pharmacological activity of imidazo[2,1-b]benzothiazole acids.
We have prepared twelve imidazo[2,1-b]benzothiazole carboxylic and acetic acids by reaction of substituted 2-aminobenzothiazoles with ethyl bromopyruvate and 4-chloroacetoacetate, respectively. The acids, obtained from esters by hydrolysis, were tested for their antiinflammatory, analgesic and ulcerogenic activities.
Grandolini
G
G
Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Facoltà di Farmacia, Università di Perugia.
Ambrogi
V
V
Perioli
L
L
de Caprariis
P
P
Palagiano
F
F
Rimoli
M G
MG
Lampa
E
E
D'Amico
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D011247:Pregnancy; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D013844:Thiazoles