HLA antigens in anti-Ro(SS-A)-positive patients with recurrent annular erythema.
BACKGROUND
Recurrent annular erythema associated with the anti-Ro(SS-A) antibody response has recently been reported in Orientals. The association is assumed to represent a distinct clinical entity.


OBJECTIVE
Our purpose was to extend knowledge on the immunogenetic spectrum of the disease.


METHODS
Sixteen anti-Ro(SS-A)-positive Japanese patients with recurrent annular erythema and Sjögren's syndrome were studied. The standard complement-dependent microcytotoxicity assay was used to type the HLA-A, -B, -C, -DR, and -DQ, as well as the HLA-DRw52 and -DRw53 antigens.


RESULTS
All 16 patients were positive for HLA-DRw52 antigens as compared with 52% of control subjects (p < 0.01 relative risk 14.8). No significant deviations were noted in the phenotype frequencies for HLA-A, -B, -C, and -DQ antigens.


CONCLUSIONS
HLA-DRw52 is closely related to annular erythema in anti-Ro(SS-A)-positive Japanese patients with Sjögren's syndrome.
Miyagawa
S
S
Department of Dermatology, Nara Medical University, Japan.
Dohi
K
K
Shima
H
H
Shirai
T
T
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D002648:Child; D004890:Erythema / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D012261:Ribonucleoproteins / Q000032:analysis*; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology*
D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D012261:Ribonucleoproteins; C035356:SS-A antibodies