Effect of anti-HLA antibodies on the long-term survival of heart and kidney allografts.
Study of anti-HLA antibodies in a population of 238 primary renal and 199 primary heart allograft recipients showed significant association between development of anti-HLA antibodies and that of chronic allograft rejection. The 5-year renal allograft survival was 70% in recipients without antibodies and 53% in recipients who developed anti-HLA alloantibodies during the first year following transplantation. Heart allograft survival at 5 years was 91% in patients without and 78% in patients with antibodies during the first 12 months posttransplantation. Development of antibodies is associated with acute rejection episodes and probably with the release of soluble HLA antigens.
Barr
M L
ML
Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
Cohen
D J
DJ
Benvenisty
A I
AI
Hardy
M
M
Reemtsma
K
K
Rose
E A
EA
Marboe
C C
CC
D'Agati
V
V
Suciu-Foca
N
N
Reed
E
E
D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000917:Antibody Formation; D001161:Arteriosclerosis / Q000209:etiology / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis; D016027:Heart Transplantation / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012189:Retrospective Studies; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D006680:HLA Antigens; D006681:HLA-D Antigens; D015395:Histocompatibility Antigens Class I