Acute urinary retention after gonadotropin-releasing hormone agonist treatment for leiomyomata uteri.
A case of rapid uterine enlargement and subsequent urinary retention occurring 7 days after GnRH-a administration in a 53-year-old premenopausal woman with myomas is presented. Rapid uterine enlargement was presumed to be caused by hyperestrogenism shortly after GnRH-a administration. The patient was treated with an indwelling Foley catheter for 2 weeks until the uterus decreased to near baseline dimensions. The patient's uterus continued to decrease in size during the 12 weeks she received GnRH-a, and she underwent an uneventful total abdominal hysterectomy and bilateral salpingectomy/oophorectomy after donating 2 units of autologous blood. This case illustrates that adverse effects from GnRH-a treatment may be caused by the transient increase in ovarian steroid secretion shortly after drug administration.
Friedman
A J
AJ
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
D000208:Acute Disease; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D016729:Leuprolide / Q000009:adverse effects*; D008875:Middle Aged; D016055:Urinary Retention / Q000139:chemically induced*; D014594:Uterine Neoplasms / Q000188:drug therapy*; D014599:Uterus / Q000187:drug effects / Q000473:pathology
D016729:Leuprolide