title: Subclinical affection of liver and kidney function and solvent exposure.
abstract: The role of solvents as hepato- and nephrotoxic agents under present-day exposure levels is still unclear. The purpose of this study involving 99 metal degreasers was to examine dose-response relationships between long-term exposure of mainly trichloroethylene and a battery of liver function tests and one nephrotubular enzyme test. Serum gamma-glutamyltransferase and urinary N-acetyl-beta-glucosaminidase were elevated by increasing solvent exposure at bivariate level. The significance of this relationship, however, was not able to withstand a multiple regression analysis, with age and alcohol abuse as confounding variables. The conclusion is that of a nonsignificant association between solvent exposure and tests screening for early liver and kidney dysfunction.
authors.affiliation: Institute of Epidemiology and Social Medicine, University of Aarhus, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Rasmussen
authors.forename: C H
authors.initials: CH
authors.lastname: Brogren
authors.forename: S
authors.initials: S
authors.lastname: Sabroe
mesh_terms: D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008111:Liver Function Tests; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D014241:Trichloroethylene / Q000009:adverse effects*
chemical_list: D014241:Trichloroethylene