Gas chromatographic-mass spectrometric method for the determination of bifemelane in human plasma at therapeutic doses.
A gas chromatographic method with mass-selective detection for the determination of bifemelane in human plasma has been developed. The assay is based on a single hexane extraction and an efficient gas chromatographic separation on a capillary column. The assay has been validated and used to support clinical pharmacokinetic studies. The lowest limit of quantitation was found to be 1 ng/ml and allowed pharmacokinetic evaluation of the drug at doses down to 50 mg.
Dill
D N
DN
MERZ & Co. GmbH & Co. Research Laboratories, Frankfurt/Main 1 Germany.
Eilbacher
B
B
D000928:Antidepressive Agents / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results
D000928:Antidepressive Agents; D001559:Benzhydryl Compounds; C031906:bifemelane