The in vivo and in vitro postantibiotic effect of aminoglycosides using a clinically isolated micro-organism.
We reported a case of abscess in which Serratia marcescens was isolated as the causative organism. We measured the postantibiotic effect (PAE) of dibekacin (DKB) and gentamicin (GM) against S. marcescens and studied the relationship between the clinical effect and the PAE. The minimal inhibitory concentration (MIC) of DKB against S. marcescens was 6.25 micrograms/mL and the serum concentration 30 min after infusion of 100 mg DKB was 5.99 micrograms/mL. The abscess was cured by the administration of DKB every 12 h. The PAE in vivo was 2.5, 2.9 and 3.3 h when DKB was administered at 50 mg/kg, 100 mg/kg and 200 mg/kg, respectively. This PAE is one of the reasons that infection can be effectively treated with intermittent administration, even if the serum concentration is below the MIC.
Arai
S
S
Department of Pediatrics, Mie University School of Medicine, Japan.
Kawamura
R
R
Kamiya
H
H
Ishii
T
T
Sakurai
M
M
D000038:Abscess / Q000188:drug therapy* / Q000382:microbiology; D000293:Adolescent; D000667:Ampicillin / Q000008:administration & dosage / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002513:Cephamycins / Q000008:administration & dosage / Q000494:pharmacology; D003023:Cloxacillin / Q000008:administration & dosage / Q000494:pharmacology; D003982:Dibekacin / Q000008:administration & dosage* / Q000494:pharmacology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008297:Male; D016868:Serratia Infections / Q000188:drug therapy*; D012706:Serratia marcescens / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002513:Cephamycins; D005839:Gentamicins; D003982:Dibekacin; D000667:Ampicillin; D003023:Cloxacillin; C046079:cefminox