title: Precocious puberty due to a lipid-cell tumour of the ovary.
abstract: A 4-year-old girl with a lipid cell tumour of the ovary showed isosexual precocious pseudopuberty. The endocrine activity of the tumour led to elevated plasma levels of dehydroepiandrosterone sulphate, oestradiol, testosterone and androstenedione. After tumour resection the clinical signs of abnormal hormonal stimulation disappeared within 10 months. The girl developed precocious puberty again 2 years later without any sign of relapse. Therapy with luteinizing hormone releasing hormone agonist was effective although premature activation of the hypothalamic-pituitary-gonadal axis could not clearly be demonstrated by hormonal investigations.
authors.affiliation: Department of Paediatrics, University of Innsbruck, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Dengg
authors.forename: F M
authors.initials: FM
authors.lastname: Fink
authors.forename: A
authors.initials: A
authors.lastname: Heitger
authors.forename: M
authors.initials: M
authors.lastname: Tabarelli
authors.forename: A
authors.initials: A
authors.lastname: Kreczy
authors.forename: J
authors.initials: J
authors.lastname: Glatzl
authors.forename: H
authors.initials: H
authors.lastname: Berger
mesh_terms: D002064:Buserelin / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications*; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D012008:Recurrence
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002064:Buserelin