The anti-idiotypic response by cynomolgus monkeys to humanized anti-Tac is primarily directed to complementarity-determining regions H1, H2, and L3.
The anti-ld response developed by cynomolgus monkeys to the humanized anti-Tac antibody was analyzed by using 12 humanized anti-Tac variants differing in V region structure. The majority of the monkey response was directed against idiotopes composed wholly or in part of complementarity-determining regions H1, H2, and L3. There was no detectable response directed solely to five single complementarity-determining regions examined or solely to the modified human V region framework.
Schneider
W P
WP
Protein Design Labs, Inc., Mountain View, CA 94043.
Glaser
S M
SM
Kondas
J A
JA
Hakimi
J
J
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D008252:Macaca fascicularis; D051379:Mice; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D007135:Immunoglobulin Variable Region; D015375:Receptors, Interleukin-2; D011993:Recombinant Fusion Proteins