Assay of certain oral contraceptive formulations by gas chromatography-mass spectrometry-selected ion monitoring.
The combined technique of gas chromatography--mass spectrometry--selected ion monitoring (GC-MS-SIM) has been employed for the nanogram level determination of ethinyloestradiol, mestranol, norgestrel and norethisterone in various oral contraceptive formulations. Steroids were assayed as their DMES-or methoxime DMES ether derivatives in the presence of ethisterone as the internal standard. The method is accurate, specific and suitable for single tablet assay.
Brooks
C J
CJ
Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Walash
M I
MI
Rizk
M
M
Zakhari
N A
NA
Toubar
S S
SS
Watson
D G
DG
D003278:Contraceptives, Oral, Hormonal / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods
D003278:Contraceptives, Oral, Hormonal