title: Effects of gallopamil, a Ca2+ channel blocker in models of ventricular arrhythmia in dogs.
abstract: The antiarrhythmic effects of gallopamil on adrenaline-, digitalis- and two-stage coronary ligation-induced arrhythmias and on adrenaline-induced triggered arrhythmia were investigated. Gallopamil suppressed adrenaline-induced and adrenaline-induced triggered arrhythmias, and these antiarrhythmic effects of gallopamil were similar to those of verapamil. Gallopamil also showed some antiarrhythmic effect on the 48-h coronary ligation-induced arrhythmia. The plasma concentration of gallopamil which decreased the arrhythmic ratio for adrenaline-induced arrhythmia by 50% (IC50) was 32 ng/ml. These results indicate that gallopamil may be a clinically useful antiarrhythmic drug.
authors.affiliation: Department of Pharmacology, Yamanashi Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: A
authors.initials: A
authors.lastname: Haruno
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine / Q000633:toxicity; D005260:Female; D005711:Gallopamil / Q000097:blood / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male
chemical_list: D000889:Anti-Arrhythmia Agents; D005711:Gallopamil; D004837:Epinephrine