title: A case of cutaneous T-cell lymphoma expressing gamma delta T-cell receptors.
abstract: Cutaneous T-cell lymphoma expressing gamma delta T-cell receptors (TCRs) is rare; only a few cases have been reported. We report another case of the disease that had a fatal outcome and differs from two previously reported cases in its clinical, histologic, and immunohistochemical aspects. The patient had multiple skin tumors with central crusts; she showed no response to chemotherapy and died within 1 year. Histologic findings included perivascular infiltrates in the dermis and subcutaneous tissue with no epidermotropism; the large lymphoid cells had a phenotype of CD1-, CD3+, CD4-, CD8-, CD25-/+, CD30-, CD38-/+, HLA-DR+, and gamma delta TCR (beta F1-, TCR delta 1+, delta TCS1-, Ti gamma A+, BB3-). The differences in the phenotype of gamma delta T-cell malignancies may reflect the uniqueness of its clinical and histologic features. A study of gamma delta T-cell malignancies may disclose important biologic features of gamma delta TCR+ cells.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.forename: F
authors.initials: F
authors.lastname: Furukawa
authors.forename: E
authors.initials: E
authors.lastname: Toichi
authors.forename: I
authors.initials: I
authors.lastname: Furukawa
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
authors.forename: S
authors.initials: S
authors.lastname: Imamura
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D010641:Phenotype; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D016692:Receptors, Antigen, T-Cell, gamma-delta