title: Demyelinating neuropathy and acute lymphocytic leukemia.
abstract: We report a 67-year-old man with acute lymphocytic leukemia (ALL) who developed a rapidly progressive areflexic quadriparesis following chemotherapy. Electrophysiologic studies demonstrated an acute demyelinating polyneuropathy. Although peripheral nervous system dysfunction in ALL is often attributed to leukemic infiltration or chemotherapy, a diligent search with electrophysiologic evaluation should be considered and may suggest alternative diagnoses.
authors.affiliation: Department of Neurology, Tufts-New England Medical Center, Boston, MA 02111.
authors.forename: K C
authors.initials: KC
authors.lastname: Gorson
authors.forename: K B
authors.initials: KB
authors.lastname: Miller
authors.forename: D C
authors.initials: DC
authors.lastname: Preston
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000368:Aged; D003711:Demyelinating Diseases / Q000150:complications* / Q000503:physiopathology; D004594:Electrophysiology; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000503:physiopathology