Elevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosis.
Two infants with subcutaneous fat necrosis had hypercalcemia that normalized during glucocorticoid treatment. The combination of hypercalcemia, normal concentration of 25-hydroxyvitamin D, an elevated concentration of 1,25-dihydroxyvitamin D, a suppressed parathyroid hormone level, and low-normal bone turnover indicated abnormal 1,25-dihydroxyvitamin D production with increased intestinal absorption of calcium. Unregulated production of 1,25-dihydroxyvitamin D by the granulomatous cells of fat necrosis may cause hypercalcemia.
Kruse
K
K
Department of Pediatrics, University of Lübeck, Bremen-Nord, Federal Republic of Germany.
Irle
U
U
Uhlig
R
R
D000273:Adipose Tissue; D001842:Bone and Bones / Q000378:metabolism; D002117:Calcitriol / Q000097:blood*; D005218:Fat Necrosis / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007231:Infant, Newborn; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone; D002117:Calcitriol