title: Accuracy and reproducibility in volumetric analysis of multiple sclerosis lesions.
abstract: The accuracy and reproducibility of dual-contrast segmentation based on nonparametric feature map analysis have been investigated in a multicomponent gelatin phantom. The root mean square errors in volume ranged from 0.02 cm3 for small volumes to 3.8 cm3 for larger volumes, with a mean error of 0.97 cm3. Average inter- and intraobserver coefficients of variation were found to be < 7% for all compartments. To evaluate the reproducibility of segmentation of clinical image data, volumes of total brain, CSF, and multiple sclerosis (MS) lesions were obtained from five image sets of MS patients. Inter- and intraobserver coefficients of variations were computed for the patient data and were found to be < 5% for brain, 17% for CSF, and 20% for MS lesions. Such variations were found to be reduced by appropriate preprocessing of the images.
authors.affiliation: Department of Radiology, University of Texas Medical School, Houston 77030.
authors.forename: E F
authors.initials: EF
authors.lastname: Jackson
authors.forename: P A
authors.initials: PA
authors.lastname: Narayana
authors.forename: J S
authors.initials: JS
authors.lastname: Wolinsky
authors.forename: T J
authors.initials: TJ
authors.lastname: Doyle
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D002555:Cerebrospinal Fluid; D019855:Ethylene Glycol; D005026:Ethylene Glycols; D005260:Female; D005539:Foramen Magnum / Q000473:pathology; D005780:Gelatin; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008961:Models, Structural; D009103:Multiple Sclerosis / Q000473:pathology*; D015588:Observer Variation; D015203:Reproducibility of Results
chemical_list: D005026:Ethylene Glycols; D005780:Gelatin; D019855:Ethylene Glycol