Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma.
A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.
Kanazawa
H
H
Kyoritsu College of Pharmacy, Tokyo, Japan.
Nagata
Y
Y
Matsushima
Y
Y
Takai
N
N
Uchiyama
H
H
Nishimura
R
R
Takeuchi
A
A
D000777:Anesthetics / Q000097:blood*; D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods*; D004285:Dogs; D007093:Imidazoles / Q000097:blood*; D013058:Mass Spectrometry / Q000379:methods*; D020926:Medetomidine
D000777:Anesthetics; D007093:Imidazoles; D020926:Medetomidine