title: A case of epidermolysis bullosa hereditaria--dominant dystrophic type of Cockayne and Touraine.
abstract: We report a patient with the Cockayne and Touraine type epidermolysis bullosa dystrophica domains. A 6-year-old Japanese female developed blisters and erosions on the extremities 3 months after birth. Immunohistology showed a linear binding pattern of the monoclonal antibody against type VII collagen (LH:2) on the epidermal basement membrane. By means of electron microscopy and morphometric analysis, it became apparent that the anchoring fibrils were rudimentary in structure and reduced in number.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yotsumoto
authors.forename: M
authors.initials: M
authors.lastname: Setoyama
authors.forename: H
authors.initials: H
authors.lastname: Hisadome
authors.forename: M
authors.initials: M
authors.lastname: Tashiro
authors.forename: F
authors.initials: F
authors.lastname: Murata
mesh_terms: D001485:Basement Membrane / Q000473:pathology; D002648:Child; D003094:Collagen; D004817:Epidermis / Q000473:pathology; D016108:Epidermolysis Bullosa Dystrophica / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans
chemical_list: D003094:Collagen