Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease.
99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietal-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demonstrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietal regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism.
Kwa
V I
VI
Department of Neurology, University of Amsterdam, The Netherlands.
Weinstein
H C
HC
Posthumus Meyjes
E F
EF
van Royen
E A
EA
Bour
L J
LJ
Verhoeff
P N
PN
Ongerboer de Visser
B W
BW
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D004569:Electroencephalography / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D015609:Organotechnetium Compounds; D010091:Oximes; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime