title: Common fragile site expression in lymphocytes from an individual mosaic for trisomy 8.
abstract: During the course of a survey of fragile site expression in lymphocytes from twins one member of a dizygotic pair was found to be mosaic for trisomy 8. One hundred fifty metaphases from this individual were analyzed (100 treated with aphidicolin and 50 untreated); 43% were 46,XY and 57% 46,XY,+8. No differences were observed between the treated and control cultures in either the proportions of normal and trisomic metaphases or the overall or specific fragile site expression in the normal and trisomic cells.
authors.affiliation: Department of Human Genetics, Virginia Commonwealth University, Medical College of Virginia, Richmond.
authors.forename: M J
authors.initials: MJ
authors.lastname: Austin
authors.forename: M C
authors.initials: MC
authors.lastname: Neale
authors.forename: L A
authors.initials: LA
authors.lastname: Corey
authors.forename: W E
authors.initials: WE
authors.lastname: Nance
authors.forename: R M
authors.initials: RM
authors.lastname: Schieken
authors.forename: J A
authors.initials: JA
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D009030:Mosaicism; D014314:Trisomy; D014429:Twins, Dizygotic