Differences in the time course of the effects of oophorectomy in women on parameters of bone metabolism and interleukin-1 levels in the circulation.
Interleukin-1 is a cytokine with bone-resorbing activity which is claimed to play a role in the pathogenesis of osteoporosis and of post-oophorectomy bone loss. We measured plasma levels of interleukin-1 (IL-1) in 16 women who underwent hysterectomy and bilateral oophorectomy and in 12 women with hysterectomy alone before surgery and 7, 15, 30, 45 and 60 days after surgery. Only oophorectomized patients showed a significant increase of circulating interleukin-1 levels. This increase was significant only 30 days after surgery, whereas a rise at 7 days (P < 0.001) was observed for serum calcium and hydroxyproline/creatinine and calcium/creatinine ratios. These data do not indicate a definite role of IL-1 in promoting bone resorption in estrogen-deficient women in vivo.
Fiore
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CE
Instituto di Clinica Medica L. Condorelli, University of Catania, Italy.
Falcidia
E
E
Foti
R
R
Motta
M
M
Tamburino
C
C
D000328:Adult; D001862:Bone Resorption / Q000209:etiology / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007375:Interleukin-1 / Q000097:blood*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000378:metabolism; D010052:Ovariectomy / Q000009:adverse effects*; D010053:Ovary / Q000502:physiology; D013997:Time Factors
D004967:Estrogens; D007375:Interleukin-1