title: Chondrosarcoma of the skull base: a series of eight cases.
abstract: Chondrosarcomas of the skull base are indolent, locally invasive tumors with a marked tendency to recur. Surgery is the mainstay of treatment because these tumors are generally resistant to other forms of treatment. A surgical approach with wide access to the skull base and one that is easily repeatable is required, because recurrence is common. We have used the LeFort I maxillotomy or mobilization of the zygoma at the time of craniotomy to obtain wide access to the skull base in eight cases of chondrosarcoma. Three patients have undergone subsequent procedures by us for recurrent disease. One patient died 30 days after the operation, and one has required an open repair of a cerebrospinal fluid leak. Good palliation of symptoms has been achieved in all survivors. These approaches fulfill the criteria for the surgical management of these difficult tumors by allowing excellent exposure, safe repetition if required, satisfactory palliation, and acceptable morbidity.
authors.affiliation: Department of Neurosurgery, Atkinson Morley's Hospital, London, England.
authors.forename: S R
authors.initials: SR
authors.lastname: Stapleton
authors.forename: P R
authors.initials: PR
authors.lastname: Wilkins
authors.forename: D J
authors.initials: DJ
authors.lastname: Archer
authors.forename: D
authors.initials: D
authors.lastname: Uttley
mesh_terms: D000328:Adult; D002813:Chondrosarcoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy / Q000379:methods; D003952:Diagnostic Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery; D009915:Orbit / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D010256:Paranasal Sinuses / Q000473:pathology; D012886:Skull / Q000473:pathology; D012888:Skull Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate