title: [Optic neuropathy in type-1 diabetes and acetylsalicylic acid-refractory thrombocyte activation].
abstract: A 26-year-old female with severe complications from type I diabetes mellitus of 17 years' duration (proliferative retinopathy, nephropathy with renal failure and nephrotic syndrome) developed rapid deterioration of vision in the right eye to 6/60 over a period of several weeks. There were no other neurological signs. Ophthalmological examination showed no worsening of the diabetic retinopathy, but the presence of bilateral optic atrophy, confirmed by visual evoked potentials. CT scan did not reveal any retrobulbar process, and MR scans of both the optic nerves and the visual pathways were unremarkable. The clinical features and the investigations pointed towards ischaemic optic atrophy. Detailed platelet studies showed intravascular platelet activation and an ADP-inducible increase in aggregation, although thromboxane formation was almost absent because of cyclooxygenase inhibition by acetylsalicylic acid. These findings suggest that the ischaemia was due to microcirculatory disturbances secondary to diabetic microangiopathy and platelet hyperreactivity.
authors.affiliation: Klinische Abteilung des Diabetes-Forschungsinstitutes, Universität Düsseldorf.
authors.forename: M
authors.initials: M
authors.lastname: Homberg
authors.forename: D
authors.initials: D
authors.lastname: Tschöpe
authors.forename: H
authors.initials: H
authors.lastname: Greber
authors.forename: T
authors.initials: T
authors.lastname: Hackländer
authors.forename: B
authors.initials: B
authors.lastname: Schwippert
authors.forename: F A
authors.initials: FA
authors.lastname: Gries
authors.forename: U
authors.initials: U
authors.lastname: Mödder
mesh_terms: D000328:Adult; D001241:Aspirin; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D003928:Diabetic Nephropathies / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D003929:Diabetic Neuropathies / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D003930:Diabetic Retinopathy / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D009896:Optic Atrophy / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D009900:Optic Nerve / Q000098:blood supply; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D001241:Aspirin