Environmental strains of Enterococcus faecium with inducible high-level resistance to glycopeptides.
High-level resistance to glycopeptides in Enterococcus faecium is associated with an inducible 39-kDa cytoplasmic membrane protein. The present paper shows that such glycopeptide-resistant E. faecium strains can not only be isolated in a definite clinical setting but also from waste water of sewage treatment plants. Nearer characterization of these and of clinical isolates by resistance pattern, biotyping, and genotyping (DNA-fingerprinting with pulsed-field gel electrophoresis) has shown that different glycopeptide-resistant E. faecium strains have been isolated from clinical sources and from waste water.
Klare
I
I
Robert Koch-Institute of the Federal Office of Health, Wernigerode, FRG.
Heier
H
H
Claus
H
H
Witte
W
W
D016172:DNA Fingerprinting; D004352:Drug Resistance, Microbial; D016984:Enterococcus faecium / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D006020:Glycopeptides / Q000494:pharmacology; D008506:Medical Waste; D012722:Sewage
D006020:Glycopeptides; D008506:Medical Waste; D012722:Sewage