Bioactive polymers 68--controlled release of neomycin-furazolidone bicomponent system from xanthan hydrogel.
The neomycin-furazolidone-xanthan complex has been synthesized. Neomycin is covalently linked to xanthan, while furazolidone is inserted in the hydrogel formed by the reaction between neomycin and xanthan. The content of neomycin and furazolidone depends on the drug rate in the reaction medium. Thus, a zero-order kinetics is obtained for the release of both neomycin and furazolidone in basic medium. The complex's antimicrobial activity is intensified.
Dumitriu
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Polytechnic Institute of Jassy, Department of Macromolecular Chemistry, Romania.
Popa
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Dumitriu
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Dumitriu
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Tara
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D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005664:Furazolidone / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005782:Gels; D006863:Hydrogen-Ion Concentration; D009355:Neomycin / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000737:chemistry; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D011135:Polysaccharides, Bacterial; D012996:Solutions; D005664:Furazolidone; D009355:Neomycin; C002563:xanthan gum