Studies of the hormonal control of postnatal testicular descent in the rat.
Dihydrotestosterone is believed to control the transinguinal phase of testicular descent based on hormonal manipulation studies performed in postnatal rats. In the present study, these hormonal manipulation experiments were repeated, and the results were compared with those obtained using the antiandrogens flutamide and cyproterone acetate. 17 beta-estradiol completely blocked testicular descent, but testosterone and dihydrotestosterone were equally effective in reversing this inhibition. Neither flutamide nor cyproterone acetate prevented testicular descent in postnatal rats despite marked peripheral antiandrogenic action. Further analysis of the data revealed a correlation between testicular size and descent. Androgen receptor blockade did not produce a marked reduction in testicular size and consequently did not prevent testicular descent, whereas estradiol alone caused marked testicular atrophy and testicular maldescent. Reduction of the estradiol dosage or concomitant administration of androgens or human chorionic gonadotropin resulted in both increased testicular size and degree of descent. These data suggest that growth of the neonatal rat testis may contribute to its passage into the scrotum.
Spencer
J R
JR
James Buchanan Brady Foundation, Department of Surgery, New York Hospital/Cornell University Medical College, New York.
Vaughan
E D
ED
Imperato-McGinley
J
J
D000726:Androgen Antagonists / Q000494:pharmacology; D000728:Androgens / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D004958:Estradiol / Q000494:pharmacology; D008297:Male; D009929:Organ Size; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000254:growth & development*
D000726:Androgen Antagonists; D000728:Androgens; D004958:Estradiol