Centrally administered ouabain aggravates central sleep apneas.
The presence of endogenous digitalis-like factors in the central nervous system suggests their functional significance in the central nervous system. Three-day infusions of three-stepped doses of the digitalis agent ouabain (1-100 ng.kg body wt-1.h-1) into the lateral cerebral ventricle of freely moving rats caused a dose-dependent increase in the number of central-apneic episodes during rapid-eye-movement sleep without affecting the time spent in rapid-eye-movement sleep or basic respiratory rate. These results suggest that endogenous digitalis-like factors may be involved in the genesis of central sleep apneas.
Sato
T
T
Department of Physiology, Kochi Medical School, Japan.
Tadokoro
M
M
Kaba
H
H
Saito
H
H
Seto
K
K
Takatsuji
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D004585:Electrooculography / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D010042:Ouabain / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D012891:Sleep Apnea Syndromes / Q000139:chemically induced* / Q000503:physiopathology; D012895:Sleep, REM / Q000187:drug effects
D010042:Ouabain