title: Older donors and kidney transplantation.
abstract: Reluctance to use kidneys from older donors (> 50 years of age) is based on reports of inferior results. We reviewed our experience with 45 kidneys transplanted from older donors. Primary nonfunction, immediate graft function, and 1-, 2- and 3-year graft survival rates were similar to those obtained with kidneys transplanted from donors aged between 20 and 40 years. Renal function at 1 year (as measured by serum creatinine) was poorer in kidneys from older donors. No beneficial effect with respect to graft survival was noted with cyclosporin therapy compared to conventional immunosuppression; however, the numbers are small. We conclude that kidneys from older donors are a valuable source for transplantation.
authors.affiliation: Department of Surgery, Beaumont Hospital, Dublin, Ireland.
authors.forename: T A
authors.initials: TA
authors.lastname: Creagh
authors.forename: P A
authors.initials: PA
authors.lastname: McLean
authors.forename: M G
authors.initials: MG
authors.lastname: Donovan
authors.forename: J J
authors.initials: JJ
authors.lastname: Walshe
authors.forename: D M
authors.initials: DM
authors.lastname: Murphy
mesh_terms: D000328:Adult; D000367:Age Factors; D003524:Cyclosporins / Q000627:therapeutic use; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D014019:Tissue Donors
chemical_list: D003524:Cyclosporins