title: Primary adenocarcinoma arising in the jejunal limb of a Roux-en-Y esophagojejunostomy: a case report.
abstract: Adenocarcinoma of the small bowel is uncommon. Due to the paucity and lack of specificity of symptoms, patients are usually seen late in the course of their illness when curative therapy, mainly represented by wide surgical resection, is unlikely. The authors report a case of primary adenocarcinoma arising in the jejunal limb transposed for a Roux-en-Y esophagojejunostomy reconstruction eight years after a total gastrectomy performed for an advanced gastric cancer (pT2N1M0), with mixed histological pattern (tubular-mucinous) and negative CEA staining of cancer cells. Evidence for excluding the possibility of a recurrence of the primitive gastric cancer was based on the different histologic pattern, positive CEA staining of cancer cells and other features of the second neoplasm. Early diagnosis of the neoplasm was made possible by its favorable anatomic location and the early onset of symptoms, which prompted effective surgical therapy (wide resection). The authors, furthermore, analyze and discuss the possible pathogenesis of the neoplasm, based on the evidence of slow jejunal limb emptying, elevated concentration of N-Nitroso compounds and contamination by N-nitrosating bacteria in the jejunal limb juice, suggesting that each of these factors could have had a role to play in the development of the jejunal malignancy.
authors.affiliation: Department of Surgery, L'Aquila University Medical School, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Guadagni
authors.forename: M
authors.initials: M
authors.lastname: Catarci
authors.forename: T
authors.initials: T
authors.lastname: Ventura
authors.forename: P
authors.initials: P
authors.lastname: Leocata
authors.forename: M
authors.initials: M
authors.lastname: Carboni
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D000713:Anastomosis, Roux-en-Y; D004947:Esophagus / Q000601:surgery*; D005743:Gastrectomy; D006801:Humans; D007580:Jejunal Neoplasms / Q000473:pathology*; D007583:Jejunum / Q000601:surgery*; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D013274:Stomach Neoplasms / Q000601:surgery