title: Cutaneous malignant melanoma of the head and neck. Analysis of treatment results and prognostic factors in 581 patients: a report from the Swedish Melanoma Study Group.
abstract: BACKGROUND
  Results of surgical treatment of cutaneous malignant melanoma (CMM) have been highly variable, probably because of patient selection. Therefore, a study of representative patients with this disease was performed.
  
  
  METHODS
  In a defined area of Sweden, 581 patients were analyzed. Clinical records and histopathologic findings were reviewed. The minimum follow-up time was 7 years. Prognostic factors were evaluated by the Cox proportional hazards model.
  
  
  RESULTS
  Evaluation of sex distribution, age, and anatomic site of the primary tumor showed that the patients were representative of all Swedish patients with CMM of the head and neck. The mean patient age at diagnosis was 64 years for both sexes. Fifty-three percent of the patients were women. Female patients had more tumors of the face than did male patients, whereas male patients were overrepresented among patients with tumors of the auricle-external ear canal and scalp-neck area. Localization to the face was observed in 68%, which is an overrepresentation of three to four times when skin surface is taken into consideration. Twenty-four percent of the patients had lentigo maligna melanoma. Only 33% of the patients had superficial spreading melanoma. In univariate analyses, sex, anatomic site of the primary tumor, histogenetic type, Clark level of invasion, and tumor thickness had prognostic power. In a multivariate analysis, tumor thickness, anatomic site of the primary tumor, and sex of the patient were independent prognostic factors.
  
  
  CONCLUSIONS
  In representative patients with CMM of the head and neck, tumor thickness, anatomic site of the primary tumor, and sex of the patients were independent prognostic factors.
authors.affiliation: Department of Oncology, Radiumhemmet, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Ringborg
authors.forename: L E
authors.initials: LE
authors.lastname: Afzelius
authors.forename: B
authors.initials: B
authors.lastname: Lagerlöf
authors.forename: H O
authors.initials: HO
authors.lastname: Adami
authors.forename: I
authors.initials: I
authors.lastname: Augustsson
authors.forename: E
authors.initials: E
authors.lastname: Blomqvist
authors.forename: B
authors.initials: B
authors.lastname: Boeryd
authors.forename: E
authors.initials: E
authors.lastname: Carlin
authors.forename: S
authors.initials: S
authors.lastname: Edström
authors.forename: J
authors.initials: J
authors.lastname: Eldh
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D012878:Skin Neoplasms / Q000556:secondary; D013548:Sweden / Q000453:epidemiology