Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.
The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.
Brill
G M
GM
Anti-infective Research, Abbott Laboratories, Abbott Park, IL 60064.
Chen
R H
RH
Rasmussen
R R
RR
Whittern
D N
DN
McAlpine
J B
JB
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D011090:Polyenes