title: Results of penetrating keratoplasty in aniridia.
abstract: Eight aniridic patients with bilateral corneal scarring, vascularization, or edema underwent corneal transplantation in one or both eyes (11 eyes). Follow-up ranged from eight months to 5 1/2 years (average, three years). Six of 11 eyes (55%) had at least a two-line improvement in visual acuity and eight of 11 (73%) had at least one line of improvement. Best-corrected visual acuity was 20/200 or worse in nine of 11 eyes (82%), however. Postoperative complications included whorl keratopathy, persistent epithelial defects, central subepithelial scarring, peripheral vascularization with pannus, and graft rejection. Glaucoma was well controlled medically but five of nine patients (56%) with preexisting glaucoma needed an increase in medication for intraocular pressure control. Graft rejection occurred in seven of 11 eyes (64%) and three of these eyes required repeat transplantation.
authors.affiliation: Cornea Service, Wills Eye Hospital, Philadelphia, Pennsylvania.
authors.forename: I
authors.initials: I
authors.lastname: Kremer
authors.forename: R K
authors.initials: RK
authors.lastname: Rajpal
authors.forename: C J
authors.initials: CJ
authors.lastname: Rapuano
authors.forename: E J
authors.initials: EJ
authors.lastname: Cohen
authors.forename: P R
authors.initials: PR
authors.lastname: Laibson
mesh_terms: D000293:Adolescent; D000328:Adult; D015783:Aniridia / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure; D015948:Keratoplasty, Penetrating; D008875:Middle Aged; D011183:Postoperative Complications; D016896:Treatment Outcome; D014792:Visual Acuity