title: Mucosal immunity in primary glomerulonephritis. III. Study of intestinal permeability.
abstract: To study the specificity of gut hyperpermeability in primary glomerulonephritis, we investigated intestinal permeability by means of 51Cr-EDTA testing in 20 healthy individuals and in 30 patients with Immunoglobulin A nephropathy (IgA GN), 25 with idiopathic nephrotic syndrome (INS) and 20 with immune complex glomerulonephritis (IC-GN; membranous+membranoproliferative glomerulonephritis). Gut permeability was statistically increased in each patient group versus the controls [controls: 2% (0.4-3.9); IgA GN: 3.25% (0.7-17.70); INS: 3.71% (0.82-10); IC-GN: 3.40% (0.30-16); results are median (range); p < 0.005, nonparametric Mann-Whitney test]. An increase in intestinal permeability exceeding the upper limit of control values (95th percentile) was observed in 36% of IgA GN, 60% of INS and 50% of IC-GN patients. We conclude that intestinal permeability is frequently increased in primary glomerulonephritis and may also be increased in types of glomerulonephritis other than IgA GN.
authors.affiliation: Department of Nephrology, INSERM-U 139, Henri-Mondor Hospital, Créteil, France.
authors.forename: G
authors.initials: G
authors.lastname: Rostoker
authors.forename: V
authors.initials: V
authors.lastname: Wirquin
authors.forename: H
authors.initials: H
authors.lastname: Terzidis
authors.forename: M
authors.initials: M
authors.lastname: Petit-Phar
authors.forename: M T
authors.initials: MT
authors.lastname: Chaumette
authors.forename: J C
authors.initials: JC
authors.lastname: Delchier
authors.forename: D
authors.initials: D
authors.lastname: Belghiti
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.forename: J M
authors.initials: JM
authors.lastname: Dubert
authors.forename: M
authors.initials: M
authors.lastname: Meignan
mesh_terms: D000328:Adult; D005921:Glomerulonephritis / Q000276:immunology* / Q000503:physiopathology; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000503:physiopathology; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology / Q000503:physiopathology; D015433:Glomerulonephritis, Membranous / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000276:immunology*; D009404:Nephrotic Syndrome / Q000276:immunology / Q000503:physiopathology; D010539:Permeability