Mapping of the KREV1 transformation suppressor gene and its pseudogene (KREV1P) to human chromosome 1p13.3 and 14q24.3, respectively, by fluorescence in situ hybridization.
The chromosomal location of the transformation suppressor gene KREV1 and its pseudogene (KREV1P) on R-banded human prometaphase chromosomes was determined by fluorescence in situ hybridization. The KREV1 gene mapped to chromosome 1p13.3, whereas the KREV1P pseudogene mapped to 14q24.3. Our results substantiate the previous mapping data of Rousseau-Merck et al. (1990) and further confine the position of the RAP1A/KREV1 gene to a narrower region.
Takai
S
S
Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
Nishino
N
N
Kitayama
H
H
Ikawa
Y
Y
Noda
M
M
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D019204:GTP-Binding Proteins / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D011905:Genes, ras; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D005810:Multigene Family; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011544:Pseudogenes; D020668:rap GTP-Binding Proteins
D011518:Proto-Oncogene Proteins; D019204:GTP-Binding Proteins; D020668:rap GTP-Binding Proteins