Immunobiological studies on experimental visceral leishmaniasis. III. Cytokine-mediated regulation of parasite replication.
The role of T-cell-derived cytokines in the regulation of Leishmania donovani replication was studied in a murine model. It was observed that in H-2d mice at the early and later stages of the disease IFN-gamma-secreting T cells predominate, whereas in between the above stages IL-4-secreting T cells predominate. Possibly, IL-4 abrogates the protective ability of IFN-gamma and thereby exponential parasite growth is ensured at the active stage of the disease. By contrast, H-2b mice were possibly incapable of inducing IL-4-secreting T cells and therefore parasite replication remains under control at any point post infection.
Saha
B
B
Leishmania Group, Indian Institute of Chemical Biology, Calcutta.
Basak
S K
SK
Roy
S
S
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D007893:Leishmania donovani / Q000254:growth & development*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010641:Phenotype; D013601:T-Lymphocytes / Q000378:metabolism
D016207:Cytokines; D015847:Interleukin-4; D007371:Interferon-gamma