title: [Cefuroxime and cefoxitin in perioperative preventive use of antibiotics. A randomized study].
abstract: In a prospectively randomized study 243 patients scheduled for gynaecologic surgery received either 2 g Cefoxitin or 1.5 g Cefuroxim at induction of anaesthesia. Both drugs were well tolerated by all study patients. Post-operative fever was seen in seven women in the Cefuroxim group (n = 121) vs. three women in the Cefoxitin group (n.s., x2-test). Wound infection occurred in two women in each group. In result Cefuroxim probably can be recommended as an alternative replacing Cefoxitin in prophylaxis, so Cefoxitin can be reserved as potent antimicrobial substance for therapy of gynaecologic infections.
authors.affiliation: Abteilung für Gynäkologie insbesondere gynäkologische Onkologie, Universitätsklinikum Essen.
authors.forename: U B
authors.initials: UB
authors.lastname: Hoyme
authors.forename: K
authors.initials: K
authors.lastname: Bühler
authors.forename: A E
authors.initials: AE
authors.lastname: Schindler
mesh_terms: D000328:Adult; D002440:Cefoxitin / Q000008:administration & dosage*; D002444:Cefuroxime / Q000008:administration & dosage*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D005833:Genital Neoplasms, Female / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002440:Cefoxitin; D002444:Cefuroxime