Sinus arrest associated with continuous-infusion cimetidine.
The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous-infusion cimetidine 50 mg/hour. The arrhythmias were temporally related to cimetidine administration, disappeared after dechallenge, and did not recur during ranitidine treatment. This is the first reported case of sinus arrest associated with continuous-infusion cimetidine.
Hulisz
D T
DT
Department of Pharmacy and Internal Medicine, Akron General Medical Center, OH 44307.
Welko
J R
JR
Heiselman
D E
DE
D000328:Adult; D001919:Bradycardia / Q000139:chemically induced*; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications; D008297:Male
D002927:Cimetidine