Sequence of the cDNA encoding bovine uridine monophosphate synthase.
A 1869-bp cDNA encoding bovine UMP synthase (UMPS), including the 3'-untranslated and 34 bp of the 5'-untranslated regions, was isolated and sequenced. The deduced amino acid sequence shows a high degree of homology to UMPS sequences reported from other species, namely for regions corresponding to the putative catalytic sites. The sequence information will be used to analyse the molecular basis of the deficiency of UMPS (DUMPS) in cattle.
Schoeber
S
S
Institute for Animal Breeding and Genetics, Hannover School of Veterinary Sciences, Germany.
Simon
D
D
Schwenger
B
B
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics*; D009962:Orotate Phosphoribosyltransferase / Q000235:genetics*; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D009097:Multienzyme Complexes; C027157:uridine 5'-monophosphate synthase; D004247:DNA; D009962:Orotate Phosphoribosyltransferase; D009964:Orotidine-5'-Phosphate Decarboxylase