Circannual and menstrual rhythm characteristics in manic episodes and body temperature.
Most reports in the literature deal with groups when summarizing the timing of affective disorders along the scale of the year and the menstrual cycle. In order to look for any regularity in timing of manic episodes in a single individual along these two time scales, a woman with a history of mania only, caused by schizoaffective disorder and on maintenance therapy with thioridazine hydrochloride self-measured basal body temperature daily and recorded onset and duration of manic episodes for 11 years. Statistically significant rhythms were found in body temperature with periods equal to the menstrual cycle and the year, with acrophase (highest values) during the luteal phase and winter, respectively. The timing of 11 manic episodes was not random but occurred during distinct portions of the menstrual cycle and the year. Most manic days occurred near menstruation or during the follicular phase of the menstrual cycle (up to ovulation) and between December and May (winter-spring). A temporal schedule for psychopharmacological treatment designed from individualized, longitudinal records that adjusts daily dosages according to both time of year and stage of menstrual cycle might alleviate or minimize the occurrence, magnitude and/or duration of mania and possibly other affective disorders that are found to be associated with underlying biological periodicities.
Sothern
R B
RB
Department of Medicine, University of Minnesota, Minneapolis 55455.
Slover
G P
GP
Morris
R W
RW
D000328:Adult; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology; D001833:Body Temperature Regulation / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D008875:Middle Aged; D010507:Periodicity; D011603:Psychophysiology; D011618:Psychotic Disorders / Q000503:physiopathology* / Q000523:psychology; D012621:Seasons