Cardiac and skeletal muscle enzyme levels in hypertensive and aging rats.
1. The activities of glycolytic, fatty acid oxidation and citric acid cycle enzymes were measured in hypertensive and aging rat cardiac and skeletal muscles. 2. Lactate dehydrogenase and beta-hydroxyacyl-CoA dehydrogenase were significantly decreased in hypertensive, but not senescent, cardiac muscle. 3. Total phosphorylase activity was significantly increased in senescent, but not hypertensive, cardiac muscle. 4. In aging rat cardiac and skeletal muscles, calpain II titers increased significantly with age, but in normotensive and hypertensive muscles, the titers showed no significant difference.
Johnson
P
P
Department of Chemistry and College of Osteopathic Medicine, Ohio University, Athens 45701.
Hammer
J L
JL
D015094:3-Hydroxyacyl CoA Dehydrogenases / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002154:Calpain / Q000378:metabolism; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D005227:Fatty Acids / Q000378:metabolism; D006019:Glycolysis; D006973:Hypertension / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D010084:Oxidation-Reduction; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D002951:Citrates; D005227:Fatty Acids; D019343:Citric Acid; D015094:3-Hydroxyacyl CoA Dehydrogenases; D007770:L-Lactate Dehydrogenase; D006005:Phosphorylases; D002154:Calpain