title: Phosphorus magnetic resonance spectroscopy of the calf muscle in patients with peripheral arterial occlusive disease.
abstract: OBJECTIVE
  To investigate the potential of 31P magnetic resonance spectroscopy (MRS) in the management of severe peripheral ischemic disease, phosphocreatine:inorganic phosphate (PCr:Pi) and PCr:adenosine triphosphate (PCr:ATP) ratios were compared with a clinical ranking of arterial insufficiency.
  
  
  METHODS
  31P MR spectra of the muscles in the lower and upper leg were measured in a group of healthy volunteers (n = 21) and in a group of patients (n = 42) with arterial occlusive disease. The patients were graded according to the categories advised by the Ad Hoc Committee on Reporting Standards (AHCRS). Spectra were obtained 12 and 20 cm below and 15 cm above the knee joint.
  
  
  RESULTS
  The PCr:Pi ratio showed a significant decrease between measurements 12 and 20 cm below the knee joint for patients with severe arterial insufficiency (AHCRS 4-6), whereas this decrease was not found in patients with mild or moderate arterial insufficiency (AHCRS 1-3).
  
  
  CONCLUSIONS
  Although the observed spatial variation in PCr:Pi ratio measured at rest does not offer profound insight into muscle physiology, the authors' results suggest that MRS may be useful in assessing the severity of peripheral vascular disease.
authors.affiliation: Department of Radiodiagnosis, University Hospital of Utrecht, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: van der Grond
authors.forename: R M
authors.initials: RM
authors.lastname: Crolla
authors.forename: W
authors.initials: W
authors.lastname: Ten Hove
authors.forename: T J
authors.initials: TJ
authors.lastname: van Vroonhoven
authors.forename: W P
authors.initials: WP
authors.lastname: Mali
mesh_terms: D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D001157:Arterial Occlusive Diseases / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D007866:Leg; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D016491:Peripheral Vascular Diseases / Q000378:metabolism* / Q000601:surgery; D010758:Phosphorus
chemical_list: D010758:Phosphorus