N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma).
Using nucleic acid analysis and in situ hybridization we have demonstrated N-myc amplification and expression in two children with a localized (stages I and II) stroma-rich neuroblastoma (NB) (ganglioneuroblastoma). The phenomenon was observed in both undifferentiated and mature ganglion-like cells. The two children are alive and disease-free without any treatment after 16 and 17 months. These observations suggest that morphologic differentiation in NB in vivo is not necessarily followed by a decrease in N-myc expression. Moreover, N-myc amplification does not represent an adverse prognostic factor. In contrast with what happens in undifferentiated NB, N-myc amplification does not have an adverse effect on prognosis when occurring in localized (stages I and II), stroma-rich NB with a favorable histology.
Fabbretti
G
G
Department of Pathology and Molecular Diagnostic Research Group, G. Gaslini Children's Hospital, Genova, Italy.
Valenti
C
C
Loda
M
M
Brisigotti
M
M
Cozzutto
C
C
Tonini
G P
GP
Callea
F
F
D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D005260:Female; D005729:Ganglioneuroma / Q000235:genetics* / Q000378:metabolism; D005784:Gene Amplification / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000235:genetics* / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism
D004273:DNA, Neoplasm; D016271:Proto-Oncogene Proteins c-myc