title: Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.
abstract: The novel antifungal agents, calbistrins A, B, C and D have been isolated from a strain of Penicillium restrictum (AB 1875C-28). The four congeners were separated by bioactivity directed fractionation using countercurrent chromatography and preparative-HPLC. NMR studies revealed that the calbistrins each contain a carboxylic acid conjugated tetraene attached through an aliphatic ester linkage to a hexahydronaphthalene system.
authors.affiliation: Anti-infective Research, Abbott Laboratories, Abbott Park, IL 60064.
authors.forename: G M
authors.initials: GM
authors.lastname: Brill
authors.forename: R H
authors.initials: RH
authors.lastname: Chen
authors.forename: R R
authors.initials: RR
authors.lastname: Rasmussen
authors.forename: D N
authors.initials: DN
authors.lastname: Whittern
authors.forename: J B
authors.initials: JB
authors.lastname: McAlpine
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D011090:Polyenes