A case of epidermolysis bullosa hereditaria--dominant dystrophic type of Cockayne and Touraine.
We report a patient with the Cockayne and Touraine type epidermolysis bullosa dystrophica domains. A 6-year-old Japanese female developed blisters and erosions on the extremities 3 months after birth. Immunohistology showed a linear binding pattern of the monoclonal antibody against type VII collagen (LH:2) on the epidermal basement membrane. By means of electron microscopy and morphometric analysis, it became apparent that the anchoring fibrils were rudimentary in structure and reduced in number.
Yotsumoto
S
S
Department of Dermatology, Faculty of Medicine, Kagoshima University, Japan.
Setoyama
M
M
Hisadome
H
H
Tashiro
M
M
Murata
F
F
D001485:Basement Membrane / Q000473:pathology; D002648:Child; D003094:Collagen; D004817:Epidermis / Q000473:pathology; D016108:Epidermolysis Bullosa Dystrophica / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans
D003094:Collagen