Radioprotective effects of the immunostimulating lauroylpeptide LtriP (RP 56142).
The lipopeptide lauroyl-L-Ala-gamma-D-Glu-L,L-A2pm (LtriP) increased the resistance of mice to the lethal effect of gamma-ray irradiation. The radioprotective effect was dependent on the doses of LtriP and of radiation. Maximum survival was observed when the lipopeptide was injected on two successive days before irradiation. This activity seems to be related to immunostimulating functions, since the non-immunostimulating analog lauroyl-L-Ala-gamma-D-Glu-D,D-A2pm-Gly, containing D,D-diaminopimelic acid, was not radioprotective. The protective activity might result from an induction of cytokines, such as IL-1, TNF and M-CSF, since LtriP induced the mRNA expression and the secretion of these immunomodulators.
Migliore-Samour
D
D
Laboratoire des protéines, CNRS URA 1188, Université de Paris V, France.
Bousseau
A
A
Caillaud
J M
JM
Naussac
A
A
Sedqi
M
M
Ferradini
C
C
Jollès
P
P
D000276:Adjuvants, Immunologic; D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D016207:Cytokines / Q000235:genetics; D005260:Female; D015870:Gene Expression; D006410:Hematopoiesis / Q000528:radiation effects; D007378:Interleukins / Q000235:genetics; D007958:Leukocyte Count / Q000528:radiation effects; D008213:Lymphocyte Activation; D016173:Macrophage Colony-Stimulating Factor / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D009842:Oligopeptides / Q000494:pharmacology*; D010867:Pimelic Acids / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D000276:Adjuvants, Immunologic; D016207:Cytokines; D007378:Interleukins; D009842:Oligopeptides; D010867:Pimelic Acids; D011837:Radiation-Protective Agents; D014409:Tumor Necrosis Factor-alpha; C024768:trimexautide; D016173:Macrophage Colony-Stimulating Factor