Immunosuppressive activity in the series of cycloamanide peptides from mushrooms.
The immunosuppressor activity of the cycloamanides A, B, C, and D, and two of their D-amino acid residue-containing analogues, was examined using PFC (plaque forming cell) and DTH (delayed type hypersensitivity) tests. It was found that cycloamanide A (CyA A, II) [c-(Phe-Phe-Ala-Gly-Pro-Val-)] and its D-Phe-containing analogue III [c-(Phe-D-Phe-Ala-Gly-Pro-Val-)] are the most potent immunosuppressors of the whole series. The retroanalogue of III [c-(D-Phe-Val-Pro-Gly-Ala-)] was found to be less active than III. The immunosuppressor activity of O-carboxymethyl-Tyr6-antamanide (I) was also tested. It was found that the substitution of one of the Phe residues of ANT by O-carboxymethyl-Tyr does not substantially affect the immunosuppressor activity.
Wieczorek
Z
Z
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Siemion
I Z
IZ
Zimecki
M
M
Bolewska-Pedyczak
E
E
Wieland
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001487:Basidiomycota / Q000737:chemistry; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic; C055018:cyclolinopeptide A; C100265:antamanide