Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.
Supporting cells in the vestibular sensory epithelia from the ears of mature guinea pigs and adult humans proliferate in vitro after treatments with aminoglycoside antibiotics that cause sensory hair cells to die. After 4 weeks in culture, the epithelia contained new cells with some characteristics of immature hair cells. These findings are in contrast to expectations based on previous studies, which had suggested that hair cell loss is irreversible in mammals. The loss of hair cells is responsible for hearing and balance deficits that affect millions of people.
Warchol
M E
ME
Department of Otolaryngology-Head and Neck Surgery, University of Virginia School of Medicine, Charlottesville 22908.
Lambert
P R
PR
Goldstein
B J
BJ
Forge
A
A
Corwin
J T
JT
D000328:Adult; D000375:Aging / Q000502:physiology; D000818:Animals; D001345:Autoradiography; D001973:Bromodeoxyuridine; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D004261:DNA Replication; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D005839:Gentamicins / Q000494:pharmacology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009355:Neomycin / Q000494:pharmacology; D012038:Regeneration; D012444:Saccule and Utricle / Q000166:cytology / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism
D005839:Gentamicins; D001973:Bromodeoxyuridine; D009355:Neomycin; D013936:Thymidine