title: Clinical outcome of cardiac patients with negative thallium-201 SPECT and positive rubidium-82 PET myocardial perfusion imaging.
abstract: In a previous comparison of 202 consecutive patients who underwent myocardial perfusion imaging with both 201Tl SPECT and 82Rb PET, 27 patients were identified as having true-positive 82Rb images, but false-negative 201Tl images. The purpose of this report is to determine the effect of correct image interpretation of coronary artery disease on the final management of those patients and compare it to the previous management scheme wherein a negative image was usually accepted as the end point unless clinical symptoms dictated otherwise. A follow-up study of the clinical course and outcome of these studies showed that 63% (17/27) of the patients with a true-positive 82Rb PET image were recommended for revascularization procedures. It is doubtful that this majority of patients would have received either surgical or interventional management based on the false-negative 201Tl SPECT procedure alone.
authors.affiliation: Department of Nuclear Medicine, Cleveland Clinic Foundation, OH 44195-5074.
authors.forename: W J
authors.initials: WJ
authors.lastname: MacIntyre
authors.forename: R T
authors.initials: RT
authors.lastname: Go
authors.forename: J L
authors.initials: JL
authors.lastname: King
authors.forename: S A
authors.initials: SA
authors.lastname: Cook
authors.forename: D R
authors.initials: DR
authors.lastname: Neumann
authors.forename: G B
authors.initials: GB
authors.lastname: Saha
authors.forename: M A
authors.initials: MA
authors.lastname: Antar
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005188:False Negative Reactions; D006801:Humans; D012414:Rubidium Radioisotopes; D013794:Thallium Radioisotopes; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D012414:Rubidium Radioisotopes; D013794:Thallium Radioisotopes