Blastomycosis in transplant recipients: report of a case and review.
Fungi cause serious, often fatal infections in immunocompromised hosts. Recipients of solid organ and bone marrow transplants are predisposed to invasive fungal infections with Candida species, Aspergillus species, and Cryptococcus neoformans. In contrast, infections with Blastomyces dermatitidis have rarely been diagnosed in transplant recipients. We describe a patient who received an orthotopic heart transplant and developed recurrent disseminated blastomycosis. Other reported cases of blastomycosis in transplant recipients are summarized. Clinical presentation, treatment options, and morbidity associated with infections with B. dermatitidis in transplant patients are reviewed.
Serody
J S
JS
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill 27599-7030.
Mill
M R
MR
Detterbeck
F C
FC
Harris
D T
DT
Cohen
M S
MS
D000666:Amphotericin B / Q000627:therapeutic use; D001759:Blastomycosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged
D000666:Amphotericin B