title: Metastatic vertebral disease in children.
abstract: We retrospectively reviewed 19 children with osseous vertebral metastases. The average age was 10.9 years at diagnosis of the primary tumor and 11.2 years at diagnosis of metastasis. The location of the multiple metastases was cervical (three), thoracic (14), and lumbar (10). Treatment consisted of chemotherapy (19), radiation therapy (12), and operation (seven). Ten children died at an average of 13 months after diagnosis of the primary tumor; nine are alive at an average of 72 months after diagnosis. All four children treated with chemotherapy, spinal radiation, and laminectomy, and who survived > 2 months, developed deformity. In this particular situation, we encourage consideration of spinal stabilization when it is appropriately coordinated with radiation and chemotherapy.
authors.affiliation: Section of Orthopaedic Surgery, University of Michigan Hospitals, Ann Arbor.
authors.forename: A A
authors.initials: AA
authors.lastname: Freiberg
authors.forename: G P
authors.initials: GP
authors.lastname: Graziano
authors.forename: R T
authors.initials: RT
authors.lastname: Loder
authors.forename: R N
authors.initials: RN
authors.lastname: Hensinger
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007796:Laminectomy; D008297:Male; D008824:Michigan / Q000453:epidemiology; D009360:Neoplastic Cells, Circulating; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000145:classification / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D015996:Survival Rate