Biphenomycin C, a precursor of biphenomycin A in mixed culture.
A precursor of biphenomycin A in mixed culture of Streptomyces griseorubiginosus No. 43708 with Pseudomonas maltophilia No. 1928 was isolated and characterized. The structure of the precursor, designated biphenomycin C was determined to be a peptide which is composed of biphenomycin A and arginylserine residue (Fig. 1), on the basis of chemical and spectroscopic evidence.
Ezaki
M
M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Shigematsu
N
N
Yamashita
M
M
Komori
T
T
Umehara
K
K
Imanaka
H
H
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004151:Dipeptides / Q000378:metabolism; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011549:Pseudomonas / Q000378:metabolism*; D013291:Streptococcus / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001713:Biphenyl Compounds; D004151:Dipeptides; D010455:Peptides; D010456:Peptides, Cyclic; D011355:Prodrugs; C047536:biphenomycin A; C079816:biphenomycin C