title: Treatment of canine nasal aspergillosis with enilconazole.
abstract: Twenty-four dogs with nasal aspergillosis were treated with enilconazole (10 mg/kg bid for 7-14 days) administered topically through tubes surgically implanted into the nasal chambers. Aspergillosis was eliminated in 19 dogs over a median follow-up period of 18 months. Another dog died, but at necropsy there was no evidence of causative fungus. Two of the four dogs that were not cured had infection of periorbital soft tissues. An additional seven dogs received 6 weeks ketoconazole (5 mg/kg bid PO) and enilconazole therapy topically. Six of these dogs were disease-free over a median follow-up period of 35 months. The seventh dog responded to repeated treatment with enilconazole. Twenty-six of the 29 dogs (90%) without extranasal aspergillosis were cured.
authors.affiliation: Department of Companion Animal and Special Species Medicine, North Carolina State University, College of Veterinary Medicine, Raleigh 27606.
authors.forename: N J
authors.initials: NJ
authors.lastname: Sharp
authors.forename: M
authors.initials: M
authors.lastname: Sullivan
authors.forename: C E
authors.initials: CE
authors.lastname: Harvey
authors.forename: T
authors.initials: T
authors.lastname: Webb
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000946:Antigens, Fungal / Q000032:analysis; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary*; D001232:Aspergillus fumigatus / Q000276:immunology; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005500:Follow-Up Studies; D007093:Imidazoles / Q000627:therapeutic use*; D007654:Ketoconazole / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D009668:Nose Diseases / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000946:Antigens, Fungal; D007093:Imidazoles; C017435:enilconazole; D007654:Ketoconazole