Eosinophilic synovitis following the intra-articular injection of bacterial antigen in horses.
Purified streptococcal M protein was injected into one intercarpal joint in three horses hyperimmunised with Streptococcus equi M protein vaccine. The contralateral joints were injected with pH adjusted polyionic solution. All antigen-injected joints developed a severe suppurative synovitis (mean synovial fluid nucleated cell count = 102,200 x 10(6) cells litre-1). Eosinophils were found in the synovial fluid and in synovial membrane biopsy specimens of two of the horses. Immune complexes were not demonstrated in the synovial membrane. Two horses are described that developed synovial fluid eosinophilia after the intra-articular injection of streptococcal antigen.
Madison
J B
JB
Department of Clinical Studies, New Bolton Center, Kennett Square, Pennsylvania 19348.
Ziemer
E L
EL
D000818:Animals; D000942:Antigens, Bacterial / Q000009:adverse effects*; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000009:adverse effects*; D002352:Carrier Proteins; D004802:Eosinophilia / Q000276:immunology / Q000662:veterinary*; D004804:Eosinophils / Q000166:cytology; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D007270:Injections, Intra-Articular / Q000662:veterinary; D007958:Leukocyte Count; D013582:Synovial Fluid / Q000166:cytology; D013585:Synovitis / Q000276:immunology / Q000662:veterinary*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein