title: A polymorphic system related to but genetically independent of the chicken major histocompatibility complex.
abstract: Analyses of the major histocompatibility complex (Mhc) in chickens have shown inconsistencies between serologically defined haplotypes and haplotypes defined by the restriction fragment patterns of Mhc class I and class II genes in Southern hybridizations. Often more than one pattern of restriction fragments for Mhc class I and/or class II genes has been found among DNA samples collected from birds homozygous for a single serologically defined B haplotype. Such findings have been interpreted as evidence for variability within the Mhc haplotypes of chickens not detected previously with serological methods. In this study of a fully pedigreed family over three generations, the heterogeneity observed in restriction fragment patterns was found to be the result of the presence of a second, independently segregating polymorphic Mhc-like locus, designated Rfp-Y. Three alleles (haplotypes) are identified in this new system.
authors.affiliation: Department of Biological Sciences, Northern Illinois University, DeKalb 60115.
authors.forename: W E
authors.initials: WE
authors.lastname: Briles
authors.forename: R M
authors.initials: RM
authors.lastname: Goto
authors.forename: C
authors.initials: C
authors.lastname: Auffray
authors.forename: M M
authors.initials: MM
authors.lastname: Miller
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics*; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006239:Haplotypes; D015183:Restriction Mapping