Effects of gallopamil, a Ca2+ channel blocker in models of ventricular arrhythmia in dogs.
The antiarrhythmic effects of gallopamil on adrenaline-, digitalis- and two-stage coronary ligation-induced arrhythmias and on adrenaline-induced triggered arrhythmia were investigated. Gallopamil suppressed adrenaline-induced and adrenaline-induced triggered arrhythmias, and these antiarrhythmic effects of gallopamil were similar to those of verapamil. Gallopamil also showed some antiarrhythmic effect on the 48-h coronary ligation-induced arrhythmia. The plasma concentration of gallopamil which decreased the arrhythmic ratio for adrenaline-induced arrhythmia by 50% (IC50) was 32 ng/ml. These results indicate that gallopamil may be a clinically useful antiarrhythmic drug.
Matsuzaki
T
T
Department of Pharmacology, Yamanashi Medical College, Japan.
Haruno
A
A
Hashimoto
K
K
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine / Q000633:toxicity; D005260:Female; D005711:Gallopamil / Q000097:blood / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male
D000889:Anti-Arrhythmia Agents; D005711:Gallopamil; D004837:Epinephrine