Cyclosporin A prolongs human hair growth in vitro.
We studied the effect of cyclosporin A on human hair growth using a recently described model in which isolated hair follicles are grown in vitro. Cyclosporin A had no effect on the rate of hair growth, but at 10(-7) M, a dose within the therapeutic blood range, it maintained hair growth for longer than control to give a 42% greater mean follicle elongation after 15 d (p < 0.05). Eighteen of 42 cyclosporin-treated follicles (43%) were still growing after 15 d compared with one of 42 control follicles (2%). These results suggest that the hypertrichotic action of cyclosporin A may be due to prolongation of the anagen phase of the hair-growth cycle.
Taylor
M
M
Department of Dermatology, Royal Hallamshire Hospital, University of Sheffield, U.K.
Ashcroft
A T
AT
Messenger
A G
AG
D016572:Cyclosporine / Q000494:pharmacology*; D006197:Hair / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D009924:Organ Culture Techniques; D012535:Scalp
D016572:Cyclosporine