title: Membrane traffic wardens and protein secretion in gram-negative bacteria.
abstract: Recent progress in the genetic analysis of protein secretion in diverse Gram-negative bacteria has revealed three major, highly conserved but functionally independent pathways that involve accessory apparatus proteins. Protein secretion via the Type I pathway is signal sequence-independent with no free periplasmic intermediate. Secretion by the Type II pathway is signal sequence-dependent and via the periplasm. Recent results also suggest that a third (Type III) secretory pathway exists in which protein secretion is signal sequence-independent.
authors.affiliation: Department of Biological Sciences, University of Warwick, Coventry, UK.
authors.forename: G P
authors.initials: GP
authors.lastname: Salmond
authors.forename: P J
authors.initials: PJ
authors.lastname: Reeves
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins