Carbonic anhydrase inhibitors. Part 11. Coordination compounds of heterocyclic sulfonamides with lanthanides are potent inhibitors of isozymes I and II.
A number of 22 lanthanide-containing coordination compounds of sulfonamides 2 and 3 were prepared and characterized by elemental analysis and spectroscopic data. The new compounds proved to be highly potent inhibitors of isozymes I and II of carbonic anhydrase.
Supuran
C T
CT
University of Bucharest, Department of Chemistry, Roumania.
Manole
G
G
Andruh
M
M
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D002417:Cattle; D003217:Conductometry; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008674:Metals, Rare Earth / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D008674:Metals, Rare Earth; D013449:Sulfonamides; D002256:Carbonic Anhydrases