title: Hyperadrenocorticism caused by bilateral adrenocortical neoplasia in dogs: four cases (1983-1988).
abstract: Hyperadrenocorticism caused by bilateral adrenocortical neoplasia was diagnosed in 4 dogs. Three dogs had bilateral adrenocortical adenomas, and 1 dog had bilateral adrenocortical carcinomas. The history, physical findings, clinicopathologic abnormalities, and results of ACTH stimulation and low-dose dexamethasone suppression tests were compatible with diagnosis of hyperadrenocorticism. Adrenocortical neoplasia was differentiated from pituitary-dependent hyperadrenocorticism on the basis of a combination of test results, including lack of suppression of plasma cortisol after being given a high dose dexamethasone (n = 4), undetectable (< 20 pg/ml) plasma endogenous ACTH concentration (n = 4), identification of a single mineralized adrenal mass by abdominal radiography (n = 2) and abdominal ultrasonography (n = 1), and identification of bilateral nonmineralized adrenal masses by ultrasonography (n = 1). A left adrenal mass was excised from 1 dog. Clinical signs persisted and administration of mitotane was initiated. One dog was treated only with mitotane. Treatment with ketoconazole was attempted in 2 dogs. All dogs died or were euthanatized because of persistent hyperadrenocorticism. Necropsy and histologic evaluation of the pituitary and adrenal tissue confirmed bilateral adrenocortical neoplasia in all dogs. Bilateral adrenocortical neoplasia should be considered as an uncommon, but possible, cause of bilaterally large adrenal glands in dogs with hyperadrenocorticism.
authors.affiliation: Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: S L
authors.initials: SL
authors.lastname: Ford
authors.forename: E C
authors.initials: EC
authors.lastname: Feldman
authors.forename: R W
authors.initials: RW
authors.lastname: Nelson
mesh_terms: D000236:Adenoma / Q000150:complications / Q000662:veterinary*; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D002277:Carcinoma / Q000150:complications / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D008297:Male; D012189:Retrospective Studies