title: Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata.
abstract: An alkaloid extract derived from the roots of Cyclea barbata demonstrated cytotoxic and antimalarial activities, and five bisbenzylisoquinoline alkaloids, (+)-tetrandrine [1], (-)-limacine [2], (+)-thalrugosine [3], (+)-homoaromoline [4], and (-)-cycleapeltine [5], were isolated as the active principles. The complete and unambiguous assignments of the 1H- and 13C-nmr data of these substances were made by 1D and 2D nmr techniques (COSY, phase-sensitive ROESY, HETCOR, and FLOCK).
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Lin
authors.forename: H L
authors.initials: HL
authors.lastname: Shieh
authors.forename: C K
authors.initials: CK
authors.lastname: Angerhofer
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
authors.forename: L
authors.initials: L
authors.lastname: Xue
authors.forename: M E
authors.initials: ME
authors.lastname: Johnson
authors.forename: N
authors.initials: N
authors.lastname: Ruangrungsi
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D001208:Asia; D044182:Benzylisoquinolines; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D066298:In Vitro Techniques; D007624:KB Cells; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines; C009438:tetrandrine; C060802:fangchinoline