title: Abnormalities of visual function in hereditary motor and sensory neuropathy.
abstract: Visual function was studied in a group of 15 patients with hereditary motor and sensory neuropathy (HMSN). Psychophysical measures of luminance and chromatic threshold and temporal contrast sensitivity were undertaken, together with visual evoked potentials (VEPs), visual fields and clinical neuro-ophthalmological examination. A patchy loss of visual function was found in individual cases of HMSN. In the group analysis there was evidence of a selective loss of luminance threshold and temporal contrast sensitivity at low temporal frequencies; the VEP P100 latency was not significantly prolonged. The losses of visual function in HMSN were discussed and compared with visual losses in multiple sclerosis, which had been detected using identical experimental techniques.
authors.affiliation: Department of Neurology, North Staffordshire Royal Infirmary, Hartshill, Stoke on Trent, UK.
authors.forename: W P
authors.initials: WP
authors.lastname: Honan
authors.forename: J R
authors.initials: JR
authors.lastname: Heron
authors.forename: D H
authors.initials: DH
authors.lastname: Foster
authors.forename: G K
authors.initials: GK
authors.lastname: Edgar
authors.forename: M O
authors.initials: MO
authors.lastname: Scase
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003118:Color Perception; D015350:Contrast Sensitivity; D005074:Evoked Potentials, Visual; D005260:Female; D015417:Hereditary Sensory and Motor Neuropathy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D012016:Reference Values; D014786:Vision Disorders / Q000209:etiology* / Q000503:physiopathology; D014796:Visual Perception