The life span of naive alpha/beta T cells in secondary lymphoid organs.
We have determined the life span of naive CD4-8+ T cells in T cell receptor transgenic mice. We find that such cells do not divide in secondary lymphoid organs in both normal euthymic mice and T cell-deficient mice. By both continuous labeling and by chasing pulse-labeled cells, we find that the minimum life span of the naive T cells is in the order of 8 wk.
von Boehmer
H
H
Basel Institute for Immunology, Switzerland.
Hafen
K
K
D000818:Animals; D016827:CD8 Antigens; D016923:Cell Death; D002455:Cell Division; D005260:Female; D008221:Lymphoid Tissue / Q000166:cytology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology
D016827:CD8 Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta