Plasma concentration of endothelin-1 in women with cocaine-associated pregnancy complications.
OBJECTIVE
The purpose of this study was to determine if the plasma concentration of endothelin-1 is elevated in pregnant women abusing cocaine and to determine how these levels differ from those in patients with preeclampsia and in women with uncomplicated pregnancies.


METHODS
Plasma endothelin-1 levels were measured in 30 women with acute cocaine intoxication, 32 women with preeclampsia, 14 pregnant women with chronic hypertension, 26 women with uncomplicated pregnancies, and 16 nonpregnant individuals. Serial samples after delivery were obtained in 12 women with preeclampsia, 10 with cocaine abuse, 4 with chronic hypertension, and 7 with uncomplicated pregnancies.


RESULTS
The mean endothelin-1 concentration in those with cocaine abuse was 18.2 +/- 8.1 pg/ml (95% confidence interval 15.2 to 21.2). This was similar to that in women with preeclampsia (21.1 +/- 5.9 pg/ml, 95% confidence interval 19 to 23.3) (p = 0.2) but significantly different from that in women with chronic hypertension (11.5 +/- 3.6 pg/ml, 95% confidence interval 9.4 to 13.6) (p < 0.001) and women with uncomplicated pregnancies (6.7 +/- 3.9 pg/ml, 95% confidence interval 5.1 to 8.2) (p < 0.001).


CONCLUSIONS
Endothelin-1 levels in women abusing cocaine are comparable to those in women with preeclampsia and are significantly higher than those in gravid women with chronic hypertension and women with uncomplicated pregnancies. Elevated levels of endothelin-1 may contribute to some of the pregnancy-related complications in women abusing cocaine.
Samuels
P
P
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia.
Steinfeld
J D
JD
Braitman
L E
LE
Rhoa
M F
MF
Cines
D B
DB
McCrae
K R
KR
D000328:Adult; D003042:Cocaine / Q000009:adverse effects*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D009994:Osmolar Concentration; D049590:Postpartum Period / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000139:chemically induced*; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D012016:Reference Values
D016232:Endothelins; D003042:Cocaine