Mechanisms in immune recovery after bone marrow transplantation. Management of posttransplant immune deficiency.
OBJECTIVE
Bone marrow transplantation usually entails the ablation of the recipient's immune system. The recovery of immunity post-marrow transplantation is a complex process dependent on a number of pre- and posttransplant factors. This knowledge has led to the development of novel approaches to supportive care of the patient, as well as to methods of augmenting immunity.


METHODS
Hematopoietic growth factors are now used to speed neutrophil recovery. Certain lymphokines are being investigated for the enhancement of cell-mediated immunity, and gamma globulin preparations are used to support the deficiency in humoral immunity.


CONCLUSIONS
This review summarizes the basic concepts of immune reconstitution posttransplant and discusses some of the therapeutic interventions that have been investigated. In addition, some general recommendations are offered regarding supportive care.
Lenarsky
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Division of Research Immunology, Children's Hospital, Los Angeles, CA 90054-0700.
D000890:Anti-Infective Agents / Q000627:therapeutic use; D000938:Antigen-Presenting Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D016465:Bone Marrow Purging / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use; D006801:Humans; D007114:Immunization; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000628:therapy; D007155:Immunologic Factors / Q000627:therapeutic use; D017053:Infection Control; D007694:Killer Cells, Natural / Q000276:immunology; D008222:Lymphokines / Q000627:therapeutic use*; D009092:Mucous Membrane / Q000276:immunology; D010587:Phagocytosis; D011182:Postoperative Care; D012867:Skin / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology
D000890:Anti-Infective Agents; D016298:Hematopoietic Cell Growth Factors; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D008222:Lymphokines