title: Cerebrovascular transit characteristics of DyDTPA-BMA and GdDTPA-BMA on normal and ischemic cat brain.
abstract: OBJECTIVE
  To compare the efficacy of two nonionic T2*-shortening contrast agents, DyDTPA-BMA dysprodiamide injection and GdDTPA-BMA gadodiamide injection, as perfusion-sensitive MR imaging agents in normal and acutely ischemic brain.
  
  
  METHODS
  The magnetic susceptibility effects of intravenous injections of 0.10-0.50 mmol/kg of each contrast agent were quantified on T2-weighted spin-echo images of cat brain before and after unilateral occlusion of the middle cerebral artery by measuring signal intensity changes in the same regions-of-interest in parietal cortex.
  
  
  RESULTS
  In normal brain, DyDTPA-BMA produced a significantly greater loss of signal intensity than equimolar doses of GdDTPA-BMA. The magnitude of the signal intensity attenuation was dosage-dependent and proportional to the square of the magnetic moments of the two contrast agents. Restoration of baseline image signal intensity was observed within 30 min after each injection. However, injection of GdDTPA-BMA also produced a delayed, persistent hyperintensity on T2-weighted images, presumably due to its underlying T1-shortening effect. Following unilateral occlusion of the middle cerebral artery, unenhanced T2-weighted images failed to show evidence of cerebral injury for 1.5-3 hours. Administration of 0.10-1.0 mmol/kg DyDTPA-BMA shortened the time for detection of perfusion deficits (residual hyperintensity) in 22 of 36 (61%) treated cats, often to within 30 min after arterial occlusion. DyDTPA-BMA enhancement also improved lesion conspicuity in 26 of 36 (72%) cases, and disclosed very small infarcts that were not visible on T2-weighted precontrast images. Perfusion deficits in areas of partial ischemia were seen more clearly on DyDTPA-BMA-enhanced images than after equimolar injections of GdDTPA-BMA.
  
  
  CONCLUSIONS
  Magnetic susceptibility contrast-enhanced MR imaging enables detection of perfusion deficits associated with acute cerebral ischemia well in advance of conventional T2-weighted spin-echo MR imaging without contrast. DyDTPA-BMA appears to delineate regions of ischemic damage better than GdDTPA-BMA.
authors.affiliation: Neuroradiology Section, University of California, San Francisco.
authors.forename: J
authors.initials: J
authors.lastname: Kucharczyk
authors.forename: H
authors.initials: H
authors.lastname: Asgari
authors.forename: J
authors.initials: J
authors.lastname: Mintorovitch
authors.forename: Z
authors.initials: Z
authors.lastname: Vexler
authors.forename: S
authors.initials: S
authors.lastname: Rocklage
authors.forename: A
authors.initials: A
authors.lastname: Watson
authors.forename: M
authors.initials: M
authors.lastname: Moseley
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis / Q000503:physiopathology*; D002415:Cats; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid; C064925:gadodiamide; D019786:Gadolinium DTPA