Pemphigus vulgaris precipitated by glibenclamide therapy.
Pemphigus vulgaris (PV) is a rare but potentially fatal autoimmune bullous disorder which frequently affects the oral mucosa. Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine. The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.
Paterson
A J
AJ
Department of Oral Medicine and Pathology, University of Glasgow, Scotland.
Lamey
P J
PJ
Lewis
M A
MA
Nolan
A
A
Rademaker
M
M
D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000209:etiology*; D015725:Fluconazole / Q000627:therapeutic use; D005905:Glyburide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D010392:Pemphigus / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use
D015725:Fluconazole; D008687:Metformin; D011239:Prednisolone; D001379:Azathioprine; D005905:Glyburide