title: [Risk of hemorrhage with the use of fluoxetine (Prozac) or fluvoxamine (Fevarin)].
abstract: Fluoxetine (Prozac) and fluvoxamine (Fevarin) are nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitors prescribed for the treatment of depression. Since these drugs block serotonin reuptake in platelets also, they might under certain conditions lead to clinically significant platelet dysfunction. Four patients are described who developed bleeding during treatment with either fluoxetine or fluvoxamine.
authors.affiliation: Bureau Bijwerkingen Geneesmiddelen, Rijswijk.
authors.forename: J P
authors.initials: JP
authors.lastname: Ottervanger
authors.forename: P M
authors.initials: PM
authors.lastname: van den Bemt
authors.forename: G H
authors.initials: GH
authors.lastname: de Koning
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000328:Adult; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D016666:Fluvoxamine / Q000009:adverse effects*; D006406:Hematoma / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans
chemical_list: D005473:Fluoxetine; D016666:Fluvoxamine