title: The anti-idiotypic response by cynomolgus monkeys to humanized anti-Tac is primarily directed to complementarity-determining regions H1, H2, and L3.
abstract: The anti-ld response developed by cynomolgus monkeys to the humanized anti-Tac antibody was analyzed by using 12 humanized anti-Tac variants differing in V region structure. The majority of the monkey response was directed against idiotopes composed wholly or in part of complementarity-determining regions H1, H2, and L3. There was no detectable response directed solely to five single complementarity-determining regions examined or solely to the modified human V region framework.
authors.affiliation: Protein Design Labs, Inc., Mountain View, CA 94043.
authors.forename: W P
authors.initials: WP
authors.lastname: Schneider
authors.forename: S M
authors.initials: SM
authors.lastname: Glaser
authors.forename: J A
authors.initials: JA
authors.lastname: Kondas
authors.forename: J
authors.initials: J
authors.lastname: Hakimi
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D008252:Macaca fascicularis; D051379:Mice; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D007135:Immunoglobulin Variable Region; D015375:Receptors, Interleukin-2; D011993:Recombinant Fusion Proteins