The use of magnetic resonance imaging to track controlled drug release and transport in the brain.
A method has been developed to track controlled drug release and transport in the brain. This method entails the use of a polymeric implant to release, over time, a paramagnetically labelled compound into the brain. Magnetic resonance imaging is used to determine the evolving concentration distribution. This method is well suited to other types of intracranial drug delivery systems as well as to track transport in other organs of the body.
Reisfeld
B
B
Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Blackband
S
S
Calhoun
V
V
Grossman
S
S
Eller
S
S
Leong
K
K
D000362:Agar; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003287:Contrast Media; D003692:Delayed-Action Preparations; D004058:Diffusion; D004343:Drug Implants; D005682:Gadolinium / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D008956:Models, Chemical; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011108:Polymers; D011817:Rabbits
D003287:Contrast Media; D003692:Delayed-Action Preparations; D004343:Drug Implants; D009942:Organometallic Compounds; D011108:Polymers; D004369:Pentetic Acid; D000362:Agar; D005682:Gadolinium; D019786:Gadolinium DTPA; C038958:gadolinium chloride