Systemic lupus erythematosus-like syndrome with focal proliferative glomerulonephritis during D-penicillamine therapy.
We report a patient with RA who developed serological evidence for lupus disease in the presence of a crescentic immune complex glomerulonephritis (GN). This occurred after 4 years therapy with penicillamine and resolved on withdrawal of this drug and following treatment with cyclophosphamide.
Donnelly
S
S
Department of Rheumatology, St Bartholomew's Hospital, London.
Levison
D A
DA
Doyle
D V
DV
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000150:complications; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D003520:Cyclophosphamide; D010396:Penicillamine