Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.
The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.
Neyfakh
A A
AA
Department of Medicinal Chemistry and Pharmacognosy (M/C 781), University of Illinois, Chicago 60680.
Borsch
C M
CM
Kaatz
G W
GW
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000201:enzymology / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D001693:Biological Transport, Active; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012110:Reserpine / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D024841:Fluoroquinolones; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012110:Reserpine; C075040:NorA protein, Staphylococcus