title: Myasthenia gravis therapy: immunoadsorbent may eliminate need for plasma products.
abstract: This in vitro study assessed the effectiveness of a new immunoadsorbent (Asahi IM-TR 350) in removing anti-acetylcholine receptor antibody from plasma with minimal loss of albumin. Plasma procured from a myasthenia gravis patient undergoing routine plasma exchange was perfused through the immunoadsorbent and recirculated in vitro to simulate a clinical treatment. To assess the temperature dependency of sorption, perfusion was performed at various temperatures. Plasma solute concentrations were taken before and after perfusion to calculate solute rejection coefficients. The immunoadsorbent has a high sorption capacity for anti-acetylcholine receptor antibody, while allowing a minimum loss of albumin. For patients with myasthenia gravis, this immunoadsorbent can provide an alternative to plasma exchange that does not require the use of plasma products.
authors.affiliation: Department of Biomedical Engineering and Applied Therapeutics, Cleveland Clinic Foundation, OH 44195.
authors.forename: K
authors.initials: K
authors.lastname: Sawada
authors.forename: P S
authors.initials: PS
authors.lastname: Malchesky
authors.forename: A P
authors.initials: AP
authors.lastname: Koo
authors.forename: H
authors.initials: H
authors.lastname: Mitsumoto
mesh_terms: D000906:Antibodies / Q000097:blood; D001781:Blood Component Removal / Q000379:methods*; D006801:Humans; D007164:Immunosorbents / Q000627:therapeutic use*; D066298:In Vitro Techniques; D009157:Myasthenia Gravis / Q000628:therapy*; D010951:Plasma Exchange; D011142:Polyvinyl Alcohol; D011950:Receptors, Cholinergic / Q000276:immunology; D014364:Tryptophan
chemical_list: D000906:Antibodies; C080036:Asahi IM-TR 350; D007164:Immunosorbents; D011950:Receptors, Cholinergic; D014364:Tryptophan; D011142:Polyvinyl Alcohol