Older donors and kidney transplantation.
Reluctance to use kidneys from older donors (> 50 years of age) is based on reports of inferior results. We reviewed our experience with 45 kidneys transplanted from older donors. Primary nonfunction, immediate graft function, and 1-, 2- and 3-year graft survival rates were similar to those obtained with kidneys transplanted from donors aged between 20 and 40 years. Renal function at 1 year (as measured by serum creatinine) was poorer in kidneys from older donors. No beneficial effect with respect to graft survival was noted with cyclosporin therapy compared to conventional immunosuppression; however, the numbers are small. We conclude that kidneys from older donors are a valuable source for transplantation.
Creagh
T A
TA
Department of Surgery, Beaumont Hospital, Dublin, Ireland.
McLean
P A
PA
Donovan
M G
MG
Walshe
J J
JJ
Murphy
D M
DM
D000328:Adult; D000367:Age Factors; D003524:Cyclosporins / Q000627:therapeutic use; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D014019:Tissue Donors
D003524:Cyclosporins