Extended follow-up in 212 long-term allogeneic bone marrow transplant survivors. Issues of quality of life.
A group of 235 allogeneic marrow recipients were contacted at least one year following their BMT to obtain information on their quality of life; 212 (90%) agreed to participate in this survey. A total of 162 adults and 50 pediatric survivors were interviewed during clinic visits (5%) or over the telephone (95%). Changes in productive activity and marital status at the time of interview were studied, as well as the presence of physical symptoms and perception of a general sense of well-being. Older transplant recipients were observed to have a significantly higher incidence of chronic graft-versus-host disease, common colds, and skin changes when compared with pediatric transplant recipients (P < 0.01). Older subjects were also more likely to require any type of regular medication. Younger survivors were rated with a higher Karnofsky performance status and global subjective score. There were no significant differences between patients who received TBI as part of the conditioning regimen and those who did not, with the exception of increased cataract development in pediatric patients receiving TBI (P < 0.008). We conclude that most allogeneic marrow transplant survivors, especially those individuals of younger age at the time of their transplants, are doing well in the domains tested.
Schmidt
G M
GM
Department of Hematology and Bone Marrow Transplantation, City of Hope Medical Center, Duarte, CA 91010.
Niland
J C
JC
Forman
S J
SJ
Fonbuena
P P
PP
Dagis
A C
AC
Grant
M M
MM
Ferrell
B R
BR
Barr
T A
TA
Stallbaum
B A
BA
Chao
N J
NJ
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000401:mortality* / Q000523:psychology / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D015996:Survival Rate; D013997:Time Factors; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation