title: Successful donation and transplantation of multiple organs from a victim of cyanide poisoning.
abstract: Demand for viable human organs for transplantation continues to exceed the supply. To expand supply, the criteria for identification and management of suitable donors must continue to evolve. Poisoned patients are often excluded as potential organ donors due to perceived risks of transmittable agents and/or physiologically compromised organs. In this report, a patient succumbed after an intentional ingestion of cyanide and multiple pharmaceuticals. Donor organ viability was determined by lack of significant injury beyond the central nervous system. Following standard procurement procedures, the heart, liver, corneas, 16 skin grafts and 16 bone grafts were deemed suitable and successfully transplanted. All organ recipients were doing well eight months post transplantation. The focus of procurement personnel should be on tissue injury and not on the mere presence of clinical effect of a toxic agent. With the paucity of organs available, poison centers need to be cognizant of this dilemma when faced with a toxicologically compromised potential organ donor.
authors.affiliation: Pittsburgh Poison Center, Children's Hospital of Pittsburgh, PA 15213.
authors.forename: B
authors.initials: B
authors.lastname: Swanson-Biearman
authors.forename: E P
authors.initials: EP
authors.lastname: Krenzelok
authors.forename: J W
authors.initials: JW
authors.lastname: Snyder
authors.forename: D W
authors.initials: DW
authors.lastname: Unkle
authors.forename: H M
authors.initials: HM
authors.lastname: Nathan
authors.forename: S L
authors.initials: SL
authors.lastname: Yang
mesh_terms: D000328:Adult; D016025:Bone Transplantation; D016039:Corneal Transplantation; D003486:Cyanides / Q000506:poisoning*; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D011039:Poison Control Centers; D011247:Pregnancy; D016038:Skin Transplantation; D014022:Tissue Survival
chemical_list: D003486:Cyanides