Reduction of liver taurine in rats by beta-alanine treatment increases carbon tetrachloride toxicity.
Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of animals with beta-alanine increases the hepatotoxicity of single doses of CCl4 as determined histologically and by measurement of serum alanine transaminase (ALT) and aspartate transaminase (AST) levels. Urinary creatine is also raised significantly after the administration of CCl4 in beta-alanine-treated animals. However, the accumulation of triglycerides (TRIG) in the liver caused by dosing with CCl4 was not influenced by beta-alanine treatment. The data suggest that liver taurine levels may be an important factor in determining the degree of CCl4-induced cellular necrosis but not hepatic triglyceride accumulation.
Waterfield
C J
CJ
Department of Toxicology, School of Pharmacy, University of London, UK.
Turton
J A
JA
Scales
M D
MD
Timbrell
J A
JA
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity*; D003401:Creatine / Q000652:urine; D004435:Eating; D008099:Liver / Q000737:chemistry* / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000032:analysis* / Q000652:urine; D014280:Triglycerides / Q000032:analysis; D015091:beta-Alanine / Q000494:pharmacology*
D014280:Triglycerides; D015091:beta-Alanine; D013654:Taurine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003401:Creatine