title: Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.
abstract: Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a lesser extent than aldehyde dehydrogenase, aldehyde reductase and glutathione-S-transferase also increase during carcinogenesis. Of the latter two enzymes, aldehyde reductase increases more markedly in a progressive fashion during the months of development of nodules and hepatoma. The increase of enzymes able to metabolize 4-hydroxynonenal, as well as other aldehydes, is certainly important in protecting tumour cells against cytotoxic effect of aldehydes.
authors.affiliation: Department of Experimental Oncology and Medicine, University of Turin, Italy.
authors.forename: R A
authors.initials: RA
authors.lastname: Canuto
authors.forename: G
authors.initials: G
authors.lastname: Muzio
authors.forename: M
authors.initials: M
authors.lastname: Maggiora
authors.forename: M E
authors.initials: ME
authors.lastname: Biocca
authors.forename: M U
authors.initials: MU
authors.lastname: Dianzani
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000449:Aldehyde Reductase / Q000378:metabolism*; D000818:Animals; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000426:Alcohol Dehydrogenase; D000449:Aldehyde Reductase; D005982:Glutathione Transferase