title: Influence of elastic recoil on restenosis after successful coronary angioplasty in unstable angina pectoris.
abstract: The elastic behavior of the dilated coronary vessel has been reported to affect the immediate results of coronary angioplasty. To determine whether elastic recoil may also influence the long-term restenosis process, 98 consecutive patients with unstable angina and 1-vessel disease were studied. An automated coronary quantitative program was used for the assessment of balloon and coronary luminal diameters. Elastic recoil was defined as the percent reduction between minimal balloon diameter at the highest inflation pressure and minimal lesion diameter immediately after coronary angioplasty. Follow-up coronary arteriography was performed 8 to 12 months after the procedure in all patients. The mean elastic recoil averaged 17.7 +/- 16% and was correlated to the degree of residual stenosis immediately after coronary angioplasty (r = 0.64; p < 0.001). Restenosis, defined as > 50% diameter stenosis at follow-up, developed in 53 patients (54%). There was no correlation between the degree of elastic recoil and the changes in minimal lesion diameter observed during follow-up, whereas a positive correlation between the amount of elastic recoil and the incidence of restenosis was documented (r = 0.84; p < 0.05). Thus, the elastic properties of the dilated vessel do not influence the active process of restenosis. However, because elastic recoil negatively influences the initial results of angioplasty, it is more likely that further reductions in lumen diameter during follow-up can reach a threshold of obstruction considered critical for a binary definition of restenosis.
authors.affiliation: Divisione di Cardiologia, Policlinico S. Matteo, Universita' di Pavia, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Ardissino
authors.forename: S
authors.initials: S
authors.lastname: Di Somma
authors.forename: J
authors.initials: J
authors.lastname: Kubica
authors.forename: P
authors.initials: P
authors.lastname: Barberis
authors.forename: P A
authors.initials: PA
authors.lastname: Merlini
authors.forename: E
authors.initials: E
authors.lastname: Eleuteri
authors.forename: S
authors.initials: S
authors.lastname: De Servi
authors.forename: E
authors.initials: E
authors.lastname: Bramucci
authors.forename: G
authors.initials: G
authors.lastname: Specchia
authors.forename: C
authors.initials: C
authors.lastname: Montemartini
mesh_terms: D000328:Adult; D000789:Angina, Unstable / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D003331:Coronary Vessels / Q000503:physiopathology*; D004548:Elasticity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence