The effect of nalbuphine and droperidol on spontaneous movements during induction of anesthesia with propofol in children.
OBJECTIVE
To investigate the effects of droperidol and nalbuphine on spontaneous movements during induction of anesthesia with propofol in children.


METHODS
Randomized, double-blind study.


METHODS
Inpatient ear, nose, and throat (ENT) surgical clinic at the University Hospital of Geneva.


METHODS
Forty-five children, ages 4 to 12 years, undergoing routine elective ENT surgery.


METHODS
Children were randomly assigned to receive either nalbuphine 0.1 mg/kg, droperidol 0.025 mg/kg, or isotonic saline 3 minutes before anesthesia induction. Induction was performed with a loading dose of propofol 3 mg/kg.


RESULTS
Spontaneous movements were observed in 33%, 87%, and 100% of patients in the nalbuphine, droperidol, and control groups, respectively. The movements were dystonic and choreiform in nature and were similar in all three groups. The frequency of spontaneous movements was significantly reduced (p < 0.05) in the nalbuphine group as compared with the droperidol and control groups.


CONCLUSIONS
Nalbuphine, but not droperidol, decreases the frequency of spontaneous movements induced by propofol during induction of anesthesia in children; neither quality of induction and recovery nor interval between the end of propofol administration and tracheal extubation were modified by nalbuphine as compared with the control group.
Borgeat
A
A
Department of Anesthesia, University Hospital of Geneva, Switzerland.
Fuchs
T
T
Wilder-Smith
O
O
Tassonyi
E
E
D000759:Adjuvants, Anesthesia / Q000009:adverse effects / Q000494:pharmacology*; D015760:Alfentanil / Q000627:therapeutic use; D000698:Analgesia; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004329:Droperidol / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D009068:Movement / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D009266:Nalbuphine / Q000009:adverse effects / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010919:Placebos; D015742:Propofol / Q000008:administration & dosage
D000759:Adjuvants, Anesthesia; D010919:Placebos; D015760:Alfentanil; D009266:Nalbuphine; D004329:Droperidol; D010100:Oxygen; D015742:Propofol