title: Cholecystokinin receptor density in the striatum of the spontaneously hypertensive rat.
abstract: The possibility that cholecystokinin in the striatum may be involved in hypertension was investigated using in vitro receptor autoradiography. The binding density of 125I-Bolton Hunter labeled cholecystokinin octapeptide (125I-BH-CCK8) was determined using computer-assisted densitometry in the striatum of the spontaneously hypertensive rat (SHR) and its control the Wistar-Kyoto rat (WKY). A significant increase in 125I-BH-CCK8 binding density was found in the lateral part of the caudate-putamen of the SHR. In contrast, a significant decrease in 125I-BH-CCK8 binding density was found in the posteromedial nucleus accumbens of the SHR. These results indicate that CCK8 receptor density is altered in the striatum of the SHR and suggest a role for CCK8 receptors in the pathophysiology of hypertension.
authors.affiliation: Division of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: G J
authors.initials: GJ
authors.lastname: Kirouac
authors.forename: P K
authors.initials: PK
authors.lastname: Ganguly
mesh_terms: D000818:Animals; D001345:Autoradiography; D002421:Caudate Nucleus / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D007457:Iodine Radioisotopes; D009474:Neurons / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011921:Rats, Inbred WKY; D011949:Receptors, Cholecystokinin / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D011949:Receptors, Cholecystokinin