title: DXS539, a polymorphic DNA marker proximal of the fragile-X gene.
abstract: We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkage analysis and physical mapping studies indicate that the pJH89 probe is located within in the interval defined by the markers DXS369 and DXS548.
authors.affiliation: Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Dreesen
authors.forename: J A
authors.initials: JA
authors.lastname: van den Hurk
authors.forename: A P
authors.initials: AP
authors.lastname: Smits
authors.forename: A M
authors.initials: AM
authors.lastname: van den Ouweland
authors.forename: P W
authors.initials: PW
authors.lastname: Markslag
authors.forename: B A
authors.initials: BA
authors.lastname: van Oost
mesh_terms: D002873:Chromosome Fragility; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D005819:Genetic Markers