Fenfluramine-induced place aversion in a three-choice apparatus.
The hedonic properties of the anorectic agent fenfluramine (0.25, 1.0, 2.5, 5.0, and 10.0 mg/kg) were assessed in two experiments in a place conditioning paradigm. After four conditioning trials, rats were tested for their preference for a drug-paired chamber, saline-paired chamber, and a novel chamber. Fenfluramine produced a place aversion at doses of 2.5-10 mg/kg.
Davies
A M
AM
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Parker
L A
LA
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002755:Choice Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D005277:Fenfluramine