title: Arterial hemodynamics and cardiac effects of enoximone, dobutamine, and their combination in severe heart failure.
abstract: The acute systemic and regional hemodynamic effects of dobutamine (5, 10, and 15 micrograms/kg/min intravenously), of enoximone (1, 1.5, and 2 mg/kg intravenously), and of the dobutamine-enoximone combination were compared in eight patients with severe congestive heart failure. Dobutamine and enoximone similarly and dose-dependently increased cardiac index and decreased systemic vascular resistance, right atrial pressure, and mean capillary wedge pressure. Dobutamine, but not enoximone, increased heart rate after 10 and 15 micrograms/kg/min. The combination of the two drugs caused a greater increase in cardiac index and a greater decrease in total peripheral resistance than did each drug alone. In the forearm vascular bed, brachial blood flow and brachial artery diameter were increased by enoximone significantly and dose-dependently and by dobutamine only at 5 micrograms/kg/min. Finally, the combination of the two drugs increased brachial blood flow but not brachial artery diameter to a larger extent than enoximone alone. Hepatosplanchnic and renal blood flows were not altered by any of the treatments. These results indicate that (1) enoximone exerts a significantly greater muscular vasodilator action than dobutamine; (2) the dobutamine-enoximone combination potentiates the systemic and brachial vasodilator effects of each drug; and (3) high doses of dobutamine (10 and 15 micrograms/kg/min) improve hemodynamics through their positive inotropic and chronotropic effects, whereas at low doses (5 micrograms/kg/min) a peripheral vasodilation also contributes.
authors.affiliation: Department of Clinical Pharmacology, Hôpital de Bicêtre, France.
authors.forename: C
authors.initials: C
authors.lastname: Thuillez
authors.forename: C
authors.initials: C
authors.lastname: Richard
authors.forename: J L
authors.initials: JL
authors.lastname: Teboul
authors.forename: D
authors.initials: D
authors.lastname: Annane
authors.forename: E
authors.initials: E
authors.lastname: Bellissant
authors.forename: P
authors.initials: P
authors.lastname: Auzepy
authors.forename: J F
authors.initials: JF
authors.lastname: Giudicelli
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D004280:Dobutamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D017335:Enoximone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004280:Dobutamine; D017335:Enoximone