title: A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.
abstract: Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
authors.affiliation: Laboratoire d'Oncologie Moléculaire, URA 1158 CNRS, Institut Gustave Roussy, Villejuif, France.
authors.forename: J
authors.initials: J
authors.lastname: Feunteun
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
authors.forename: H T
authors.initials: HT
authors.lastname: Lynch
authors.forename: P
authors.initials: P
authors.lastname: Watson
authors.forename: T
authors.initials: T
authors.lastname: Conway
authors.forename: J
authors.initials: J
authors.lastname: Lynch
authors.forename: J
authors.initials: J
authors.lastname: Parboosingh
authors.forename: P
authors.initials: P
authors.lastname: O'Connell
authors.forename: R
authors.initials: R
authors.lastname: White
authors.forename: G M
authors.initials: GM
authors.lastname: Lenoir
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002170:Canada; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17; D005192:Family Health; D005260:Female; D015870:Gene Expression; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D014481:United States
chemical_list: D005819:Genetic Markers