The effect of trospium chloride on oesophageal motility.
Trospium chloride is a muscarinergic antagonist acting on oesophageal smooth muscle and on ganglionic and/or myenteric neurons. The effect of this drug on oesophageal motility was tested in 16 healthy male subjects in a double-blind randomized cross-over examination of trospium chloride or placebo following phentolamine or placebo application. Each subject underwent two separate investigations at least one week apart. Trospium chloride was effective in the oesophagus to reduce contractile activity (amplitude and duration of peristalsis) in all parts of the oesophageal body, and this effect was not blocked by phentolamine. Its potent action and its minor side-effects appear to be promising for clinical use in patients with motility disorders such as the hypercontractile oesophagus.
Frieling
T
T
Heinrich Heine University Hospitals, Department of Gastroenterology, Duesseldorf, Germany.
Enck
P
P
Dohmann
R
R
Wienbeck
M
M
Lübke
H J
HJ
D000328:Adult; D000368:Aged; D001561:Benzilates; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004947:Esophagus / Q000187:drug effects* / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009662:Nortropanes / Q000009:adverse effects / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology
D001561:Benzilates; D009662:Nortropanes; C003330:trospium chloride; D010646:Phentolamine