[Olive oil dietary supplementation decreases susceptibility of LDL to oxidation and its uptake by macrophages].
In atherogenesis, both peroxidation of low density lipoprotein (LDL) and accumulation of cholesterol in macrophages are involved. An oleic acid-rich diet was recently shown to reduce the susceptibility of rabbit and human LDL to in vitro oxidation. We therefore supplemented the diet of 10 normal men for 2 weeks with 50 g/d of olive oil, which is rich in oleic acid. This resulted in enrichment of their LDL with oleic acid (C18:1) and with sitosterol. After only 1 week LDL susceptibility to in vitro oxidation was significantly reduced, by 30% (p < 0.01). Macrophage uptake of LDL by the J-774A.1 macrophage-like cell line was reduced by 61%. We conclude that an olive oil-enriched diet possesses antiatherogenic properties, since it reduces the susceptibility of LDL to in vitro oxidation and inhibits uptake of LDL by macrophages.
Aviram
M
M
Lipid Research Laboratory, Rambam Medical Center, Rappaport Faculty of Medicine, Haifa.
Kassem
E
E
D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology; D010084:Oxidation-Reduction; D010938:Plant Oils / Q000008:administration & dosage* / Q000494:pharmacology
D004042:Dietary Fats, Unsaturated; D008077:Lipoproteins, LDL; D009829:Oleic Acids; D010938:Plant Oils