DXS539, a polymorphic DNA marker proximal of the fragile-X gene.
We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkage analysis and physical mapping studies indicate that the pJH89 probe is located within in the interval defined by the markers DXS369 and DXS548.
Dreesen
J C
JC
Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
van den Hurk
J A
JA
Smits
A P
AP
van den Ouweland
A M
AM
Markslag
P W
PW
van Oost
B A
BA
D002873:Chromosome Fragility; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
D005819:Genetic Markers