title: Update on artificial sweeteners and bladder cancer.
abstract: Review of the most recent epidemiologic studies indicates there is no detectable association between artificial sweetener consumption and bladder cancer. The summary relative risk from a meta-analysis of all case-control studies approaches unity (RR .97). This analysis, in combination with new evidence for a unique mechanism of saccharin carcinogenicity in the male rat, leads to the conclusion that saccharin is not related to bladder cancer in humans.
authors.affiliation: Environmental Health Strategies, Inc., Redwood City, California 94065.
authors.forename: M
authors.initials: M
authors.lastname: Elcock
authors.forename: R W
authors.initials: RW
authors.lastname: Morgan
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D012307:Risk Factors; D012439:Saccharin / Q000009:adverse effects* / Q000031:analogs & derivatives; D012737:Sex Factors; D013045:Species Specificity; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D012439:Saccharin