title: Constitutive heterochromatin polymorphisms in children with acute lymphoblastic leukemia.
abstract: The C-band heterochromatin polymorphisms of chromosomes 1, 9, and 16 were studied on peripheral lymphocytes of 67 children with acute lymphoblastic leukemia (ALL) and 50 control individuals. A statistically significant difference between patients and controls was found for large heterochromatin regions (level 3) of chromosomes 1 and 9 (P < 0.001) and for small heterochromatin regions (level 1) of chromosome 16 (P < 0.001). The patients also showed a significant increase in chromosomes 1 and 9 heteromorphism with respect to controls (P < 0.001).
authors.affiliation: 2nd Department of Pediatrics, University of Athens, P & A Kyriakou Children's Hospital, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Tsezou
authors.forename: S
authors.initials: S
authors.lastname: Kitsiou-Tzeli
authors.forename: H
authors.initials: H
authors.lastname: Kosmidis
authors.forename: K
authors.initials: K
authors.lastname: Paidousi
authors.forename: K
authors.initials: K
authors.lastname: Katsouyanni
authors.forename: C
authors.initials: C
authors.lastname: Sinaniotis
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006570:Heterochromatin; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000166:cytology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012016:Reference Values
chemical_list: D006570:Heterochromatin