title: Volumetric and functional liver blood flow are both increased in the human transplanted liver.
abstract: This study measured volumetric liver blood flow and galactose clearance concurrently during orthotopic liver transplant in human subjects. Ultrasound transit time flowmeters measured hepatic artery and portal vein flow 1-3 h after reperfusion. Galactose (100 mg/min) was infused over 45-60 min to steady state for calculation of clearance. Mean +/- S.D. total volumetric flow was 1966 +/- 831 ml/min with portal flow contributing 86%. Mean galactose clearance was 1988 +/- 641 ml/min. There was a significant correlation (p < 0.05, r = 0.61) between volumetric total liver blood flow and galactose clearance. The data show that: (i) the newly transplanted liver is capable of metabolizing galactose within 1-3 h of reperfusion; and (ii) liver blood flow is high in the newly implanted liver. The clinical importance of this observation is that there is increased clearance of high first pass substances by the transplanted liver which may be of importance in patient management.
authors.affiliation: Emory University School of Medicine, Department of Surgery, Atlanta, GA.
authors.forename: J M
authors.initials: JM
authors.lastname: Henderson
authors.forename: G J
authors.initials: GJ
authors.lastname: Mackay
authors.forename: M H
authors.initials: MH
authors.lastname: Kutner
authors.forename: B
authors.initials: B
authors.lastname: Noe
mesh_terms: D001810:Blood Volume / Q000502:physiology*; D005690:Galactose / Q000493:pharmacokinetics*; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D008102:Liver Circulation / Q000502:physiology*; D016031:Liver Transplantation / Q000502:physiology*; D008657:Metabolic Clearance Rate; D011169:Portal Vein / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D005690:Galactose