The same fractions of Haemonchus contortus soluble antigen induce lymphocyte responses in naive lambs and immune sheep.
Soluble antigen extracted from third stage larvae of Haemonchus contortus was divided into fractions based on molecular weight by sodium dodecyl sulphate polyacrylamide gel electrophoresis and electrotransferred to nitrocellulose. Infection immunised adult sheep and H contortus naive lambs were used to examine the lymphocyte responses to these fractions in vitro. The results demonstrate that the same two fractions induced the strongest responses in both groups of animals.
Torgerson
P R
PR
Department of Clinical Veterinary Medicine, University of Cambridge.
Lloyd
S
S
D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis; D006188:Haemonchiasis / Q000276:immunology / Q000662:veterinary*; D006189:Haemonchus / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control
D000947:Antigens, Helminth