title: Treatment of arteriosclerotic obstruction by LDL adsorption.
abstract: According to the authors' clinical analysis, about half of the patients who suffer from arteriosclerotic obstruction (ASO) in the lower extremity(-ies) with clinical manifestation are dyslipidemic (total cholesterol > or = 220 mg/dL or LDL cholesterol > or = 140 mg/dL). As suggested by clinical success in regression of ASO in the coronary arteries as a result of aggressive removal of LDL, LDL adsorption utilizing an extracorporeal circulation technique with a dextran sulfate/cellulose adsorbent column was applied in 33 patients (22 men and 11 women) with ASO. Clinical results obtained after a series of 10 LDL adsorption procedures as a standard showed encouraging success. Improvement in subjective symptoms was achieved as follows: 88.5% for cold lower extremity, 87.1% for intermittent claudication, 53.8% for leg/toe pain at rest, and 60% for disappearance/size diminution of ulcer/necrosis. Improvements in objective examination findings supported subjective ones: 85.7% by plethysmography, 81% by thermography and 70% by ankle pressure index. No serious complications or untoward effects were observed during or after the adsorption procedures. In conclusion, LDL adsorption appears to be a useful and safe tool in treatment of ASO patients with dyslipidemia.
authors.affiliation: Kidney Center, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Agishi
authors.forename: S
authors.initials: S
authors.lastname: Naganuma
authors.forename: S
authors.initials: S
authors.lastname: Nakasato
authors.forename: K
authors.initials: K
authors.lastname: Kitajima
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: K
authors.initials: K
authors.lastname: Ban
authors.forename: M
authors.initials: M
authors.lastname: Nomura
mesh_terms: D000327:Adsorption; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000150:complications / Q000628:therapy*; D001781:Blood Component Removal; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology; D007866:Leg / Q000098:blood supply; D008297:Male
chemical_list: D008078:Cholesterol, LDL