title: Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.
abstract: 3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.
authors.affiliation: Lineberger Comprehensive Cancer Research Center, University of North Carolina, Chapel Hill 27599-7295.
authors.forename: M S
authors.initials: MS
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Kessler
authors.forename: C D
authors.initials: CD
authors.lastname: Rankin
authors.forename: J S
authors.initials: JS
authors.lastname: Pagano
authors.forename: J
authors.initials: J
authors.lastname: Kurtzberg
authors.forename: S G
authors.initials: SG
authors.lastname: Carter
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D015224:Dideoxynucleosides / Q000494:pharmacology*; D004357:Drug Synergism; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; C057503:carbovir; D015215:Zidovudine