title: Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3.
abstract: The 70-kDa peroxisomal membrane protein (PXMP1) is a member of the ATP-binding cassette transporter family. In humans, mutations in this gene may be responsible for a subset of patients with Zellweger syndrome, a lethal inborn error of peroxisome assembly. The PXMP1 gene was assigned to human chromosome 1p21-p22 by in situ hybridization and its murine homologue (Pxmp-1) to chromosome 3 by interspecific backcross analysis.
authors.affiliation: Department of Pediatrics, Kennedy Krieger Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
authors.forename: J
authors.initials: J
authors.lastname: Gärtner
authors.forename: W
authors.initials: W
authors.lastname: Kearns
authors.forename: C
authors.initials: C
authors.lastname: Rosenberg
authors.forename: P
authors.initials: P
authors.lastname: Pearson
authors.forename: N G
authors.initials: NG
authors.lastname: Copeland
authors.forename: D J
authors.initials: DJ
authors.lastname: Gilbert
authors.forename: N A
authors.initials: NA
authors.lastname: Jenkins
authors.forename: D
authors.initials: D
authors.lastname: Valle
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007425:Intracellular Membranes / Q000737:chemistry*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008830:Microbodies / Q000737:chemistry*; D015211:Zellweger Syndrome / Q000235:genetics
chemical_list: D005819:Genetic Markers; D008565:Membrane Proteins; D004247:DNA