A non-lymphocyte-depleting monoclonal antibody to the adhesion molecule LFA-1 (CD11a) prevents sensitization to alloantigens and effectively prolongs the survival of heart allografts.
Nakakura
E K
EK
Department of Cardiothoracic Surgery, Stanford University Medical Center, California.
McCabe
S M
SM
Zheng
B
B
Shorthouse
R A
RA
Scheiner
T M
TM
Blank
G
G
Jardieu
P M
PM
Morris
R E
RE
D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use; D006085:Graft Survival / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology* / Q000502:physiology; D006789:Host vs Graft Reaction / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007519:Isoantigens / Q000276:immunology*; D008213:Lymphocyte Activation; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009200:Myocardial Contraction; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D007519:Isoantigens; D016169:Lymphocyte Function-Associated Antigen-1; D016572:Cyclosporine