In vivo use of rapamycin suppresses neither IL-2 production nor IL-2 receptor expression in rat transplant model.
Hamashima
T
T
Second Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Yoshimura
N
N
Ohsaka
Y
Y
Oka
T
T
Stepkowski
S M
SM
Kahan
B D
BD
D000818:Animals; D001803:Blood Transfusion; D002478:Cells, Cultured; D005434:Flow Cytometry; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D011090:Polyenes / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis* / Q000187:drug effects; D020123:Sirolimus; D013154:Spleen / Q000276:immunology; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D007376:Interleukin-2; D011090:Polyenes; D015375:Receptors, Interleukin-2; D020123:Sirolimus