title: [A case of complete remission of breast cancer with bilateral multiple lung metastases by combination therapy of MPA, THP, CPM and 5-FU].
abstract: A 55-year-old female was admitted for right breast tumor with multiple bilateral lung metastases. Modified radical mastectomy (Auchincloss method) was carried out. And the combination chemoendocrine therapy was undertaken using CPA 100 mg p.o. days 1-18, THP 40 mg i.v. days 1, 8, 5-FU 500 mg i.v. days 1, 8 and MPA 1,200 mg p.o. daily. One month later, the lung metastases completely disappeared on chest CT gram. Nine courses of chemotherapy with the same drugs were undertaken intravenously every four weeks. This therapy has been continuously effective for one and half years now. These results suggested the importance of a severe adjuvant therapy for the initial phase of advanced breast cancer.
authors.affiliation: Dept. of Surgery, Tokyo Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Kusama
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Koyanagi
authors.forename: H
authors.initials: H
authors.lastname: Kaise
authors.forename: M
authors.initials: M
authors.lastname: Arima
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: J
authors.initials: J
authors.lastname: Murata
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D015411:Mastectomy, Modified Radical; D008525:Medroxyprogesterone / Q000008:administration & dosage*; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; C027260:pirarubicin; D008525:Medroxyprogesterone; D005472:Fluorouracil