Prolonged QT interval and torsade de pointes following astemizole overdose.
A 26 year-old woman was admitted to the hospital two hours after astemizole overdose. Electrocardiograph showed a prolonged QT interval. Torsade de pointes occurred 13 h after ingestion. Plasma levels of astemizole plus hydroxylated metabolites showed an apparent plasma half-life of 17 h. The possible occurrence of torsade de pointes in astemizole overdose, and the long elimination time of astemizole and hydroxylated metabolites, makes it necessary to maintain ECG monitoring until QT interval has returned to normal.
Saviuc
P
P
Toxicologie Clinique, Centre Hospitalier de Grenoble, France.
Danel
V
V
Dixmerias
F
F
D000328:Adult; D016589:Astemizole / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005751:Gastric Lavage; D006207:Half-Life; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy
D016589:Astemizole; D007545:Isoproterenol