Differential protein binding of ceftizoxime in cord versus maternal serum.
Ceftizoxime concentrations are higher in cord blood and amniotic fluid than in maternal blood. More avid binding to fetal serum proteins is a suggested mechanism. We measured ceftizoxime protein binding in fetal and maternal blood and documented significantly less protein binding to fetal proteins (21.9% vs 57.8%).
Fortunato
S J
SJ
Department of Obstetrics and Gynecology, Tulane University, School of Medicine, New Orleans, LA 70112.
Welt
S I
SI
Stewart
J T
JT
D000653:Amniotic Fluid / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D015296:Ceftizoxime / Q000097:blood* / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011485:Protein Binding
D001798:Blood Proteins; D015296:Ceftizoxime