title: Prevalence of hepatitis B virus markers among intravenous drug abusers in Stockholm: impact of heterosexual transmission.
abstract: In order to study the importance of sexual transmission of hepatitis B virus (HBV) among intravenous drug abusers (IVDAs), and from IVDAs to others, we consecutively interviewed 171 IVDAs detained at the Stockholm Remand Prison during 4 months in 1990. Sexual histories revealed that 77% reported > or = 3 sexual partners during the last 3 years, 64% had had a sexual partner who did not inject drugs, and 61% reported a prior STD. The prevalence of HBV markers was 75%. In a multiple logistic regression analysis, a high risk for HBV markers was associated with an increasing duration of drug abuse, a high prevalence of hepatitis A markers, and an increasing number of drug injecting sexual partners during the last 3 years, indicating that sexual transmission, along with sharing of needles, may contribute to the high prevalence of HBV markers within this group. It is suggested that an adequate sexual history must be obtained from IVDAs with acute viral hepatitis in order to identify sexual partners who should be offered postexposure prophylaxis, and that non-immune IVDAs should be vaccinated against viral hepatitis A and B.
authors.affiliation: Department of Infectious Diseases, Karolinska Institute, Huddinge Hospital, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Struve
authors.forename: K
authors.initials: K
authors.lastname: Käll
authors.forename: P
authors.initials: P
authors.lastname: Stendahl
authors.forename: G
authors.initials: G
authors.lastname: Scalia-Tomba
authors.forename: J
authors.initials: J
authors.lastname: Giesecke
authors.forename: O
authors.initials: O
authors.lastname: Weiland
mesh_terms: D000328:Adult; D015415:Biomarkers; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology; D006506:Hepatitis A / Q000150:complications / Q000453:epidemiology; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D008297:Male; D012307:Risk Factors; D012725:Sexual Behavior; D012747:Sexual Partners; D015819:Substance Abuse, Intravenous / Q000150:complications*; D013548:Sweden / Q000453:epidemiology
chemical_list: D015415:Biomarkers