A study on the effect of lesions of area 7 of the parietal cortex on the short-term visual spatial memory of rhesus monkeys (Macaca mulatta).
This research is focused on the contribution of area 7 to the short-term visual spatial memory. Three rhesus monkeys (Macaca mulatta) were trained in the direct delayed response task in which 5 delay intervals were used in each session. When each monkey reached the criterion of 90% correct responses in 5 successive sessions, two monkeys underwent a surgery while the other one received a sham operation as a control. In the first stage of the surgery, bilateral areas 7a, 7b and 7ip of the parietal cortex of two monkeys were precisely lesioned. After 7 days of recuperation, the monkeys were required to do the same task. The average percentage of correct responses in the lesioned animals decreased from 94.7% to 89.3% and 93.3% to 82.0% respectively (no significance, P > 0.05, n = 2). In addition, the monkeys' complex movements were mildly impaired. The lesioned monkeys were found to have difficulty picking up food from the wells. In the second stage, bilateral area 7m was lesioned. In the 5 postoperative sessions, the average percentage of correct responses in one monkey, with a relatively precise 7m lesion, decreased from 94.7% to 92.2% (no significance, P > 0.05), while the other monkey, with widely spread necrosis of lateral parietal cortex, showed an obvious decline in performance, but still over the chance level. After 240 trials this monkey reattained the normal criterion.(ABSTRACT TRUNCATED AT 250 WORDS)
Pu
X
X
Kunming Institute of Zoology, Academia Sinica, Yunnan, People's Republic of China.
Ma
Y
Y
Cai
J
J
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology / Q000502:physiology*; D004594:Electrophysiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D008568:Memory / Q000502:physiology*; D009069:Movement Disorders / Q000473:pathology / Q000503:physiopathology; D010296:Parietal Lobe / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*