title: Efficacy of 100 consecutive right ventricular endomyocardial biopsies in pediatric patients using the right internal jugular venous approach.
abstract: Indications for endomyocardial biopsy (EMB) in pediatric patients include cardiomyopathy and postheart transplant rejection surveillance. There have been few reports of the use of the internal jugular venous approach for right ventricular EMB in pediatric patients. In this study, we report our experience with 100 consecutive EMBs in pediatric patients using this approach. Indications for EMB were cardiomyopathy of unknown etiology in four patients, adriamycin cardiomyopathy in three patients, postheart transplant rejection surveillance in five patients, right ventricular outflow tract tumors in one patient, and sustained ventricular tachycardia in one patient. Histologic diagnoses of biopsy specimens included interstitial fibrosis, vasculopathy, hypertrophy, anthracycline cardiotoxicity, and various degrees of allograft rejection. All EMBs were performed successfully and without complications. We conclude that right ventricular EMB using the right internal jugular venous approach can be performed safely and successfully in pediatric patients as young as 2 months of age and repeatedly in patients as young as 8 years old.
authors.affiliation: Department of Pediatrics, University of Utah, Salt Lake City.
authors.forename: R E
authors.initials: RE
authors.lastname: Shaddy
authors.forename: E A
authors.initials: EA
authors.lastname: Bullock
mesh_terms: D000293:Adolescent; D001706:Biopsy / Q000379:methods; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004317:Doxorubicin / Q000009:adverse effects; D004699:Endocardium / Q000473:pathology*; D005260:Female; D006084:Graft Rejection / Q000473:pathology*; D016027:Heart Transplantation / Q000473:pathology*; D006801:Humans; D007223:Infant; D007601:Jugular Veins; D008297:Male; D009206:Myocardium / Q000473:pathology*
chemical_list: D004317:Doxorubicin