Nitrosation of the antimicrobial drug hexetidine: nitrosamines derived from a triamine decomposition product.
Five new nitrosamines were identified as nitrosation products of N1,N3-bis(2-ethylhexyl)-2-methyl-1,2,3-propantriamine, a hydrolysis product usually found in preparations of the antimicrobial drug hexetidine. All nitrosamines are formed after deamination of the primary amino group by nitrosation of one of the two secondary amino groups. The propantriamine derivative is very easily nitrosatable, with total nitrosamine yields in the upper range of a comparative scale of drug nitrosatability.
Mende
P
P
Department of Environmental Carcinogens, German Cancer Research Center, Heidelberg.
Wacker
C D
CD
Preussmann
R
R
Spiegelhalder
B
B
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006590:Hexetidine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009573:Nitrites / Q000737:chemistry; D009602:Nitrosamines / Q000737:chemistry*; D015538:Nitrosation; D011073:Polyamines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D009573:Nitrites; D009602:Nitrosamines; D011073:Polyamines; C003224:propoctamine; D006590:Hexetidine