Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin.
The bactericidal/permeability increasing protein is a major element in the host defense against Gram-negative bacteria and endotoxin, acting intracellularly in the polymorphonuclear leukocyte. As an isolated protein, bactericidal/permeability increasing protein also acts as an extracellular bactericidal and endotoxin-neutralizing agent and, when injected, protects animals against lethal effects of Gram-negative bacteria and endotoxin.
Elsbach
P
P
Department of Medicine, New York University School of Medicine, New York 10016.
Weiss
J
J
D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001770:Blood Bactericidal Activity; D001798:Blood Proteins / Q000502:physiology*; D003165:Complement System Proteins / Q000502:physiology; D004731:Endotoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D006090:Gram-Negative Bacteria; D016905:Gram-Negative Bacterial Infections / Q000276:immunology; D006801:Humans; D008565:Membrane Proteins; D008954:Models, Biological; D009504:Neutrophils / Q000201:enzymology / Q000502:physiology*; D010740:Phospholipases / Q000502:physiology
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D004731:Endotoxins; D008565:Membrane Proteins; C021623:bactericidal permeability increasing protein; D003165:Complement System Proteins; D010740:Phospholipases