Relationship of regression pattern to recurrence in retinoblastoma.
A retrospective analysis has been conducted of regression patterns following treatment of retinoblastoma by external beam irradiation. There were 180 tumours in 105 eyes of 83 patients. Type I regression was found to be the commonest pattern and occurred in 50% of cases. Initial tumour size was found to be the only statistically significant determinant of regression pattern (p < 0.01). Thirteen tumours (7%) recurred within a median interval to recurrence of 12 months. All recurrences occurred within 40 months of completion of treatment and none occurred after age 4 years. No tumour less than 6 mm in diameter recurred. Although 10 out of 13 recurrences were of Type I, Cox model regression analysis showed initial tumour size to be the only independent predictor of recurrence (p < 0.01).
Singh
A D
AD
Department of Ophthalmology, St Bartholomew's Hospital, West Smithfield, London.
Garway-Heath
D
D
Love
S
S
Plowman
P N
PN
Kingston
J E
JE
Hungerford
J L
JL
D002675:Child, Preschool; D005134:Eye Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007223:Infant; D008297:Male; D009364:Neoplasm Recurrence, Local; D012160:Retina / Q000473:pathology; D012175:Retinoblastoma / Q000473:pathology / Q000532:radiotherapy*; D012189:Retrospective Studies; D013997:Time Factors