Synthesis and some properties of two salsalate derivatives.
The synthesis of esters of 2-hydroxy benzoic acid-2-carboxyphenyl ester (salsalate) with guaiacol for the treatment of inflammatory bronchopneumopathies is reported. The antiinflammatory, analgesic and antipyretic activities of these derivatives were evaluated, together with their antioxidant, mucolytic and broncho-bacteriostatic properties in comparison to acetylsalicylic acid.
Galzigna
L
L
Department of Biological Chemistry - University of Padova.
Licit
L
L
De Pieri
G F
GF
Bonora
G M
GM
Signor
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D000996:Antitussive Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001241:Aspirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D002855:Chromatography, Thin Layer; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005100:Expectorants / Q000138:chemical synthesis / Q000494:pharmacology; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013056:Spectrophotometry, Ultraviolet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D000996:Antitussive Agents; D005100:Expectorants; D012459:Salicylates; C080457:guaiacol-salsalate; D006139:Guaiacol; D001241:Aspirin; C023557:guacetisal