title: A 6-month home usage trial of a 1% chlorhexidine toothpaste (II). Effects on the oral microflora.
abstract: The effects of 1% chlorhexidine and 1% chlorhexidine/fluoride dentifrices on supragingival plaque flora were investigated in a 6-month home-usage study. 146 subjects were studied from whom plaque around 6 teeth was collected at baseline, 6 weeks and 24 weeks. Total anaerobic counts were reduced at 6 and 24 weeks in both active groups compared to control. No differences were seen in any other bacterial parameters. There was a significant decrease in the susceptibility to chlorhexidine of bacteria recovered from the subjects on the active treatments compared to control but, since the magnitude of effect was less than one dilution, this was not thought to be of any clinical significance.
authors.affiliation: Department of Periodontology, Dental School, University of Wales College of Medicine, Heath Park, Cardiff, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Maynard
authors.forename: S M
authors.initials: SM
authors.lastname: Jenkins
authors.forename: J
authors.initials: J
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Addy
authors.forename: R G
authors.initials: RG
authors.lastname: Newcombe
authors.forename: W G
authors.initials: WG
authors.lastname: Wade
mesh_terms: D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification*; D001420:Bacteria, Aerobic / Q000302:isolation & purification; D001421:Bacteria, Anaerobic / Q000302:isolation & purification; D001439:Bacteroides / Q000302:isolation & purification; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology* / Q000517:prevention & control; D004338:Drug Combinations; D016967:Fusobacterium nucleatum / Q000302:isolation & purification; D005891:Gingivitis / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D014100:Toothpastes
chemical_list: D004338:Drug Combinations; D014100:Toothpastes; D012969:Sodium Fluoride; C010882:chlorhexidine gluconate; D002710:Chlorhexidine