LINAC radiosurgery: an animal model.
Fifteen cats were irradiated with an animal LINAC (linear accelerator) radiosurgery device. After 6 months, they were studied with gadolinium-enhanced magnetic resonance (MR) imaging, gross pathology after Evans blue perfusion, and histopathology. The lesion size was relatively constant in the cats receiving a dose of 7500, 10,000, 12,500, or 15,000 cGy to the 84% isodose line of a 1-cm collimator. The composition of the lesion correlated with dose: the lower-dose lesions were found histologically to contain areas of edema, demyelination, reactive gliosis, and vascular proliferation; the higher-dose lesions contained increasing amounts of hemorrhage and coagulative necrosis. The borders of the lesions were sharply demarcated from surrounding normal brain. Gadolinium-enhanced MR studies correlated well with areas of blood-brain barrier breakdown, as confirmed by areas of Evans blue staining. This model could serve as the basis for further studies of the biological effects of LINAC radiosurgery.
Spiegelmann
R
R
Department of Neurosurgery, University of Florida, Gainesville.
Friedman
W A
WA
Bova
F J
FJ
Theele
D P
DP
Mickle
J P
JP
D000818:Animals; D001921:Brain / Q000473:pathology / Q000528:radiation effects / Q000601:surgery*; D002415:Cats; D004307:Dose-Response Relationship, Radiation; D008279:Magnetic Resonance Imaging; D016634:Radiosurgery / Q000379:methods*