title: Antimicrobial prophylaxis in surgery: microbiological factors.
abstract: Various aspects of prophylaxis in surgery are discussed. The timing of antibiotic doses is analysed in relation to the Burke laboratory model and the lag-phase of bacterial growth. Areas where further data is required: the effect of locally applied antibiotics, protection against sources of organisms and new approaches to prophylaxis are discussed. The ecological effects of antibiotics are described in relation to prophylaxis.
authors.affiliation: Edgware General Hospital, Middlesex, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Sanderson
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents