Cyclosporine and rapamycin block protein kinase C-mediated induction of the activation signal, activator of DNA replication, in cell-free assay.
Kimball
P
P
Dept. of Surgery, University of Texas Medical School, Houston 77030.
Kerman
R H
RH
Williams
J
J
Kahan
B D
BD
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D002474:Cell-Free System; D016572:Cyclosporine / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects*; D004790:Enzyme Induction; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000276:immunology*; D010879:Piperazines / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020123:Sirolimus
D007166:Immunosuppressive Agents; D007546:Isoquinolines; D010879:Piperazines; D011090:Polyenes; D016572:Cyclosporine; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; C053177:N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide; D011493:Protein Kinase C; D020123:Sirolimus