Translocation (8;13) and T-cell lymphoma. A case report.
A patient with a myeloproliferative disorder is described with an eosinophilia together with T-cell lymphoma. A unique translocation t(8;13)(p11.2;q12) was present in all bone marrow cells examined at presentation. No evidence of this translocation was found in a peripheral blood lymphocyte culture. Chromosome analysis after 9 months revealed this same translocation as well as an extra chromosome 21 in all cells; 4.5% of cells also had an additional chromosome 9. The morphologic diagnosis at this stage was chronic myelomonocytic leukemia. Immunophenotyping 3 months later was consistent with a stem-cell leukemia.
Fagan
K
K
Cytogenetics Laboratory, John Hunter Hospital, Newcastle, New South Wales, Australia.
Hyde
S
S
Harrison
P
P
D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D002882:Chromosomes, Human, Pair 13; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D004802:Eosinophilia / Q000150:complications; D016391:Genes, src; D006801:Humans; D016130:Immunophenotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000209:etiology / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications; D014411:Neoplastic Stem Cells / Q000473:pathology; D011289:Preleukemia / Q000235:genetics; D014178:Translocation, Genetic; D014314:Trisomy