Radioprotective effect of N-acetylcysteine on granulocyte/macrophage colony-forming cells of human bone marrow.
N-Acetylcysteine, known as a radical scavenger, was examined for its influence on the radiotolerance of progenitor cells of granulocytopoiesis. Added before and after irradiation in a dose of 2 mg/ml to suspension cultures of non-adherent low-density human bone marrow cells N-acetylcysteine (AcCys) clearly improved the survival. The D0 value of the survival curve for granulocyte/macrophage colony-forming cells increased by a factor of 1.56 as compared to non-treated control suspensions. The improvement of radiation tolerance is probably not only based on the radical scavenger properties (radioprotective component) of AcCys, but also on the support of repair processes.
Selig
C
C
Institute of Occupational and Social Medicine, University of Ulm, Federal Republic of Germany.
Nothdurft
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W
Fliedner
T M
TM
D000111:Acetylcysteine / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006098:Granulocytes / Q000187:drug effects* / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects* / Q000528:radiation effects; D011837:Radiation-Protective Agents; D013997:Time Factors
D011837:Radiation-Protective Agents; D000111:Acetylcysteine