Constitutive heterochromatin polymorphisms in children with acute lymphoblastic leukemia.
The C-band heterochromatin polymorphisms of chromosomes 1, 9, and 16 were studied on peripheral lymphocytes of 67 children with acute lymphoblastic leukemia (ALL) and 50 control individuals. A statistically significant difference between patients and controls was found for large heterochromatin regions (level 3) of chromosomes 1 and 9 (P < 0.001) and for small heterochromatin regions (level 1) of chromosome 16 (P < 0.001). The patients also showed a significant increase in chromosomes 1 and 9 heteromorphism with respect to controls (P < 0.001).
Tsezou
A
A
2nd Department of Pediatrics, University of Athens, P & A Kyriakou Children's Hospital, Greece.
Kitsiou-Tzeli
S
S
Kosmidis
H
H
Paidousi
K
K
Katsouyanni
K
K
Sinaniotis
C
C
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006570:Heterochromatin; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000166:cytology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012016:Reference Values
D006570:Heterochromatin