title: Thymic carcinoma. A distinct clinical entity responsive to chemotherapy.
abstract: BACKGROUND
  Thymic carcinomas are rare tumors of the anterior mediastinum. These tumors are distinct thymic neoplasms that differ from their more common counterpart, thymoma. As opposed to thymomas, thymic carcinomas are histologically malignant neoplasms with a clinical course that tends to be much more aggressive than that of patients with thymoma.
  
  
  METHODS
  Between 1984 and 1990, five patients with thymic carcinoma treated with cisplatin-based combination chemotherapy were seen at Indiana University Hospital. These patients' diagnoses, courses, and treatments were reviewed.
  
  
  RESULTS
  Three patients responded (two completely) to cisplatin-based chemotherapy.
  
  
  CONCLUSIONS
  This form of chemotherapy merits additional study in such patients, and our experience indicates that at least some will have clinically meaningful responses. The optimum regimen is unclear, but would contain cisplatin and probably should be similar to that used in germ cell tumors.
authors.affiliation: Department of Medicine, Indiana University, Indianapolis.
authors.forename: L G
authors.initials: LG
authors.lastname: Weide
authors.forename: T M
authors.initials: TM
authors.lastname: Ulbright
authors.forename: P J
authors.initials: PJ
authors.lastname: Loehrer
authors.forename: S D
authors.initials: SD
authors.lastname: Williams
mesh_terms: D000328:Adult; D000708:Anaplasia; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002945:Cisplatin / Q000008:administration & dosage*; D003593:Cytoplasm / Q000648:ultrastructure; D003896:Desmosomes / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D007382:Intermediate Filaments / Q000648:ultrastructure; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D013945:Thymoma / Q000188:drug therapy* / Q000473:pathology*; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D002945:Cisplatin