Synergy of cefotaxime and fosfomycin against penicillin-resistant pneumococci.
The killing kinetics of cefotaxime and fosfomycin, alone and in combination, against seven clinical isolates of penicillin-resistant pneumococci were studied. The antibiotics were tested at 1 x, 2 x and 4 x the MIC for each individual isolate. The results showed a synergic interaction of the two antibiotics for three of the seven strains. This strategy may be useful clinically.
Barakett
V
V
Laboratoire Central de Microbiologie, CHU Saint-Antoine, Paris, France.
Lesage
D
D
Delisle
F
F
Burghoffer
B
B
Richard
G
G
Vergez
P
P
Petit
J C
JC
D002439:Cefotaxime / Q000494:pharmacology*; D004357:Drug Synergism; D005578:Fosfomycin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D005578:Fosfomycin; D002439:Cefotaxime