Prevention of autoimmune inflammatory polyarthritis in male New Zealand black/KN mice by transplantation of bone marrow cells plus bone (stromal cells).
OBJECTIVE
To prevent polyarthritis in male New Zealand black/KN (NZB/KN) mice by transplantation of both bone marrow cells (BMC) and bone (to recruit stromal cells) from normal mice.


METHODS
Arthritic lesions in male NZB/KN mice injected intravenously with BMC plus bone from C57Bl/10 mice were compared with those in untreated male NZB/KN mice.


RESULTS
Male NZB/KN mice engrafted with BMC plus bone were both radiologically and histopathologically normal, and had decreased production of anti-single-stranded DNA antibodies and rheumatoid factors at 8-12 months of age.


CONCLUSIONS
Bone marrow transplantation prevented polyarthritis in male NZB/KN mice.
Nakagawa
T
T
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Nagata
N
N
Hosaka
N
N
Ogawa
R
R
Nakamura
K
K
Ikehara
S
S
D000818:Animals; D001168:Arthritis / Q000276:immunology / Q000517:prevention & control* / Q000601:surgery; D001175:Arthrography; D001327:Autoimmune Diseases / Q000517:prevention & control; D016026:Bone Marrow Transplantation; D016025:Bone Transplantation; D002678:Chimera; D004195:Disease Models, Animal; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D008934:Mitogens / Q000502:physiology; D013583:Synovial Membrane / Q000473:pathology
D008934:Mitogens