title: In vitro-in vivo correlation for modified-release formulations.
abstract: A correlation of in vitro dissolution rate measurements with in vivo pharmacokinetic results in a human study was obtained for a sustained-release formulation of bromocriptine. Different methods were applied to reach this correlation, and the various outcomes were compared.
authors.affiliation: Department of Anesthesia, University Hospital, University of Basel/Kantonsspital, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Drewe
authors.forename: P
authors.initials: P
authors.lastname: Guitard
mesh_terms: D000328:Adult; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002214:Capsules; D003692:Delayed-Action Preparations; D006207:Half-Life; D006801:Humans; D008297:Male; D008954:Models, Biological; D011674:Pulse / Q000187:drug effects; D011786:Quality Control; D012995:Solubility
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D001971:Bromocriptine