title: Clinical trials for removal of bilirubin by high-capacity nonionic adsorbent.
abstract: To remove bilirubin from patients with hyperbilirubinemia, nonionic macroporous adsorbent NK-110 was tailor-made from styrene and divinyl benzene at Nankai University. Five patients were perfused through shunts filled with 500 ml of the above adsorbent. After 2 h of hemoperfusion, total bilirubin decreased within the range of 22-51%. During the treatment, no noticeable changes in electrolytes, urea nitrogen, serum glutamicpyruvic transaminase (SGPT), TTT, and amino acid concentrations were observed. Platelet depletion was satisfactory. Hemoglobin, white cell count, globulin, and albumin showed no remarkable changes. The nonionic adsorbent shows a high efficacy for bilirubin removal and has a great potential for future clinical applications.
authors.affiliation: Institute for Molecular Biology, Nankai University, Tianjin, China.
authors.forename: C Z
authors.initials: CZ
authors.lastname: Chen
authors.forename: Y T
authors.initials: YT
authors.lastname: Yu
authors.forename: J C
authors.initials: JC
authors.lastname: Song
authors.forename: P
authors.initials: P
authors.lastname: Yuan
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Du
mesh_terms: D000327:Adsorption; D000328:Adult; D001663:Bilirubin / Q000097:blood*; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D006932:Hyperbilirubinemia / Q000628:therapy*; D007475:Ion Exchange Resins; D008297:Male; D008875:Middle Aged; D011137:Polystyrenes; D016062:Porosity
chemical_list: D007475:Ion Exchange Resins; D011137:Polystyrenes; C051007:NK 110 resin; D001663:Bilirubin