title: Chemotherapeutic trials with four drugs in crossbred calves experimentally infected with Theileria annulata.
abstract: Groups of calves were infected by the injection of ground-up-tick supernatant from ticks infected with ODE-Anand stock of Theileria annulata, the causative agent of tropical theileriosis. Treatment with long-acting oxytetracycline, at 20 mg kg-1, injected intramuscularly, had no effect against severe Theileria annulata infection when administered either as a single injection on the day of infection or as three injections given on days 8, 10 and 12 after infection. Halofuginone lactate, given orally at 1.2 mg kg-1 was effective but caused anorexia, diarrhoea and debility. Parvaquone at 20 mg kg-1 intramuscularly given on day 11 after infection, had a marked suppressive effect, while buparvaquone was highly effective. A single treatment with buparvaquone, either at 5 mg kg-1 or 2.5 mg kg-1 intramuscularly, rapidly eliminated schizonts and piroplasms of T annulata. At 5 mg kg-1 it resulted in rapid recovery of all the treated calves.
authors.affiliation: Animal Disease Research Laboratory, National Dairy Development Board, Anand, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: Thakur
authors.forename: P R
authors.initials: PR
authors.lastname: Raghav
authors.forename: B C
authors.initials: BC
authors.lastname: Varshney
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002417:Cattle; D008297:Male; D009285:Naphthoquinones / Q000627:therapeutic use; D010118:Oxytetracycline / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D052999:Quinazolinones; D016796:Theileria annulata / Q000187:drug effects*; D013801:Theileriasis / Q000188:drug therapy*; D010880:Piperidines
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones; D010118:Oxytetracycline; D011799:Quinazolines; D052999:Quinazolinones; C046326:buparvaquone; C028032:parvaquone; C010176:halofuginone; D010880:Piperidines