title: A sclerodermatous syndrome with unusual features following prolonged occupational exposure to organic solvents.
abstract: We describe a sclerodermatous syndrome in a middle-aged man who had worked with a wide variety of organic solvents over a prolonged period. Associated changes included cold sensitivity, a restrictive lung defect, peripheral neuropathy, oesophageal dysfunction, labile hypertension and a monoclonal paraproteinaemia. This unique syndrome is discussed in relation to other disorders associated with exposure to organic solvents.
authors.affiliation: Department of Dermatology, General Infirmary, Leeds, U.K.
authors.forename: W W
authors.initials: WW
authors.lastname: Bottomley
authors.forename: R A
authors.initials: RA
authors.lastname: Sheehan-Dare
authors.forename: P
authors.initials: P
authors.lastname: Hughes
authors.forename: W J
authors.initials: WJ
authors.lastname: Cunliffe
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D002617:Chemical Industry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000188:drug therapy; D012997:Solvents / Q000009:adverse effects*
chemical_list: D012997:Solvents; D011239:Prednisolone; D001379:Azathioprine