Stroke morbidity in patients treated for hypertension--The Skaraborg Hypertension Project.
Stroke incidence was analysed in a Swedish cohort of male (n = 1428) and female (n = 1812) hypertensive patients in comparison with age- and sex-matched population controls (1:1) and with normotensive untreated subjects (1249 men and 1247 women). Mean follow-up was 8.3 years. Patients were aged 40-69 at the start of follow-up in 1977-1981. Relative risks (95% confidence interval [CI]) for stroke morbidity were 1.63 (1.16, 2.29) for men and 1.40 (0.94, 2.09) for women compared to population controls. Corresponding figures for stroke mortality were 1.96 (1.01-3.82) and 1.48 (0.71-3.06). Compared to the normotensive sample with adjustment for smoking and body mass index relative risks for stroke morbidity were 3.07 (1.96-4.80) for men and 2.56 (1.46-4.51) for women. The prognosis of treated hypertension with respect to stroke is better than anticipated from previous studies, a fact that should be considered when treatment guidelines are developed.
Lindblad
U
U
Department of Community Health Sciences, University of Lund, Malmö, Sweden.
Råstam
L
L
Ranstam
J
J
D000328:Adult; D000368:Aged; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000628:therapy*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012737:Sex Factors; D016019:Survival Analysis; D013548:Sweden / Q000453:epidemiology