Nuclear signaling by interleukin-6.
The molecular analysis of the regulation of nuclear proteins induced by interleukin-6 has provided new insights into this largely unknown signal transduction pathway. Transcription factors of the CCAAT/enhancer-binding protein and AP-1 families, as well as the octamer-binding proteins and the tumor suppressor gene product pRB, are regulated by interleukin-6 in a cell type specific manner, suggesting that they may play a role in the nuclear signaling by interleukin-6.
Chen-Kiang
S
S
Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York.
Hsu
W
W
Natkunam
Y
Y
Zhang
X
X
D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D016350:Leucine Zippers / Q000502:physiology; D005810:Multigene Family; D050813:Octamer Transcription Factor-2; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology; D016160:Retinoblastoma Protein / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology
D004268:DNA-Binding Proteins; D015850:Interleukin-6; D050813:Octamer Transcription Factor-2; C058435:POU2F2 protein, human; D016755:Proto-Oncogene Proteins c-jun; D016160:Retinoblastoma Protein; D014157:Transcription Factors