Myocardial ischemia after treatment with methotrexate, etoposide and cisplatin.
Cisplatin exerts an additional influence on myocardial ischemia induced by the cardiovascular effects of etoposide. Two cases of myocardial ischemia related to combination chemotherapy with methotrexate, etoposide and cisplatin are reported. While the major toxicity associated with systemic chemotherapy is hematologic, it is suggested that, in elderly patients with increased incidence of atherosclerotic disease, special attention be given to vascular complications of antineoplastic agents.
Igawa
M
M
Department of Urology, Hiroshima University School of Medicine, Japan.
Kadena
H
H
Ohkuchi
T
T
Ueda
M
M
Usui
T
T
Matsuura
H
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced* / Q000175:diagnosis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D005047:Etoposide; D002945:Cisplatin; D008727:Methotrexate