Rat intestinal epithelial cell line IEC-6 is activated by recombinant interferon-gamma to inhibit replication of the coccidian Toxoplasma gondii.
Toxoplasma gondii tachyzoites invaded and replicated in cultured rat small intestine cells of the line IEC-6. Treatment of rat small intestine cells with murine recombinant interferon-gamma resulted in a dose-dependent inhibition of intracellular T. gondii replication. This could be of relevance as a first line defense against Toxoplasma infection.
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Unité de Recherche Université-INRA d'Immunologie Parasitaire, UFR des Sciences Pharmaceutiques de Tours, France.
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D000818:Animals; D002460:Cell Line; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000469:parasitology*; D051381:Rats; D011994:Recombinant Proteins; D014122:Toxoplasma / Q000254:growth & development* / Q000276:immunology
D011994:Recombinant Proteins; D007371:Interferon-gamma