Transplacental transfer of cefuroxime in uncomplicated pregnancies and those complicated by hydrops or changes in amniotic fluid volume.
The transplacental transfer of cefuroxime was determined at antenatal fetal blood sampling in a cross sectional study of 78 patients between 15-35 weeks' gestation, 8-138 minutes after a maternal intravenous dose of 750 mg. Mean serum cefuroxime concentration, measured by high performance liquid chromatography, was 7.4 (95% confidence interval (CI) 6.8 to 8.1) mg/l in control fetuses; concentrations in hydropic fetuses were similar (6.2 mg/l, CI 4.7 to 7.7) but in fetuses with oligohydramnios they were significantly lower, (4.9 mg/l, CI 3.6 to 6.2). Antibiotic concentration did not correlate with gestational age and remained unchanged by transfusion of packed red cells. We conclude that (i) fetal serum concentrations of cefuroxime obtained after a maternal dose of 750 mg are only adequate for prophylaxis against organisms with a minimum inhibitory concentration of < 4 mg/l and (ii) transplacental passage of cefuroxime is significantly reduced in the presence of oligohydramnios.
Holt
D E
DE
Royal Postgraduate Medical School's Institute of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, London.
Fisk
N M
NM
Spencer
J A
JA
de Louvois
J
J
Hurley
R
R
Harvey
D
D
D000653:Amniotic Fluid / Q000737:chemistry; D002444:Cefuroxime / Q000032:analysis / Q000493:pharmacokinetics*; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D015160:Hydrops Fetalis / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D016104:Oligohydramnios / Q000378:metabolism*; D011247:Pregnancy / Q000378:metabolism*
D002444:Cefuroxime