Brominated indole alkaloids from the marine tunicate Pseudodistoma arborescens.
Chemical investigation of the cytotoxic CH2Cl2-soluble extract of the marine tunicate Pseudodistoma arborescens led to the isolation of four brominated indole alkaloids, arborescidines A [1], B [2], C [3], and D [4], which were characterized by their spectral data, especially 2D nmr. Only arborescidine D [4] showed moderate activity (IC50 3 micrograms/ml) in vitro against the growth of KB human buccal carbinoma cells.
Chbani
M
M
Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
Païs
M
M
Delauneux
J M
JM
Debitus
C
C
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D014561:Urochordata / Q000737:chemistry*
D000470:Alkaloids; D000970:Antineoplastic Agents; D007211:Indoles