title: Effects of acetazolamide on acid-base balance in the endolymphatic sac of the guinea pig.
abstract: The effects of acetazolamide, a carbonic anhydrase inhibitor, on acid-base parameters in the endolymphatic sac of the guinea pig were investigated using ion-selective microelectrodes. Bicarbonate concentration was reduced and pH shifted to being acidic immediately after administration of acetazolamide. Chloride concentration in the endolymphatic sac increased after carbonic anhydrase inhibition. These findings provide evidence of an active function of carbonic anhydrase in the endolymphatic sac and suggest that carbonic anhydrase activity is involved in the formation of endolymphatic sac fluid.
authors.affiliation: Department of Otorhinolaryngology, Kansai Medical University, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tsujikawa
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: K
authors.initials: K
authors.lastname: Tomoda
authors.forename: H
authors.initials: H
authors.lastname: Iwai
authors.forename: H
authors.initials: H
authors.lastname: Kumazawa
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: T
authors.initials: T
authors.lastname: Kumazawa
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology*; D000136:Acid-Base Equilibrium / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000502:physiology*; D002712:Chlorides / Q000378:metabolism; D004712:Endolymphatic Sac / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D002256:Carbonic Anhydrases; D000086:Acetazolamide