Treatment of toxic epidermal necrolysis and Stevens-Johnson syndrome in children.
A retrospective study was carried out on eight consecutively treated children, 2 to 14 years of age, seven with toxic epidermal necrolysis and one with transitional-type Stevens-Johnson syndrome. The body surfaces affected ranged from 40% to 100%. Seven of the patients were taking a sulfonamide or anticonvulsant before the onset of their disease. Complete reepithelialization took an average of 15 days, but newly evolving lesions of the lips and oropharynx continued for approximately 4 more weeks. These lesions took an additional 2 to 4 weeks to heal. Only one of the children died.
Barone
C M
CM
George David Peak Memorial Burn Care Center, University of Missouri, Hospital and Clinics, Division of Plastic Surgery, Columbia 65212.
Bianchi
M A
MA
Lee
B
B
Mitra
A
A
D000293:Adolescent; D001414:Bacitracin / Q000627:therapeutic use; D001458:Bandages; D001830:Body Surface Area; D002648:Child; D002675:Child, Preschool; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D009059:Mouth Diseases / Q000473:pathology / Q000628:therapy*; D010636:Phenols / Q000627:therapeutic use; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing
D010636:Phenols; D001414:Bacitracin; D008012:Lidocaine; C004554:2,4,6-tribromophenol