A Drosophila photoreceptor cell-specific protein, calphotin, binds calcium and contains a leucine zipper.
The calphotin protein, encoded by the calphotin (cap) gene, is expressed in the soma and axons of all Drosophila photoreceptor cells. It is expressed early in photo-receptor cell development, at the time when cell-type decisions are being made. Expression of calphotin is not altered by the glass mutation, which blocks photoreceptor cell development. The calphotin protein binds calcium and contains a long C-terminal leucine zipper. Potential implications of these properties are discussed.
Ballinger
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DG
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY.
Xue
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Harshman
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KD
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004330:Drosophila / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins; D004926:Escherichia coli / Q000235:genetics; D015151:Immunoblotting; D007301:Insect Hormones / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D019476:Insect Proteins; D016350:Leucine Zippers / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009838:Oligodeoxyribonucleotides; D010786:Photoreceptor Cells / Q000378:metabolism* / Q000648:ultrastructure; D017433:Protein Structure, Secondary; D015183:Restriction Mapping; D014158:Transcription, Genetic
D000911:Antibodies, Monoclonal; D002135:Calcium-Binding Proteins; C079658:Cpn protein, Drosophila; D029721:Drosophila Proteins; D007301:Insect Hormones; D019476:Insect Proteins; D009838:Oligodeoxyribonucleotides; D004247:DNA; D002118:Calcium