title: [Caesarean section in a patient with past history of fulminant malignant hyperthermia].
abstract: Caesarean section in a 26 year old patient (50 kg, normal weight 36 kg) with past history of fulminant malignant hyperthermia (f-MH) is reported. Hyperthermia over 42 degrees C and subsequent cardiac arrest occurred during general anesthesia with nitrous oxide-oxygen-halothane and succinylcholine when she had been planned to perform hip joint arthroplasty at the age of 7. Prophylactic oral dantrolene administration started 4 days before the operation and the dose went up to 75 mg. Further 25 mg was given as premedication on the day of the operation. Intravenous dantrolene was administered 1.2 mg.kg-1 during the operation and 0.6 mg.kg-1 on the day after surgery. The Caesarean section was performed under spinal anesthesia with hyperbaric tetracaine 20 mg. No clinical symptoms of MH occurred during perioperative period. The delivered baby was a healthy female and no side effects of dantrolene were observed.
authors.affiliation: Department of Anesthesiology, Nagasaki University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Ogata
authors.forename: T
authors.initials: T
authors.lastname: Fujie
authors.forename: T
authors.initials: T
authors.lastname: Fujigaki
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Yukinari
authors.forename: O
authors.initials: O
authors.lastname: Shibata
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D002585:Cesarean Section; D003620:Dantrolene / Q000008:administration & dosage*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008305:Malignant Hyperthermia / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D013748:Tetracaine
chemical_list: D013748:Tetracaine; D003620:Dantrolene