Radiation doses obtained from 99mTc-labelled human milk fat globule monoclonal antibodies.
Human milk fat globule (HMFG) monoclonal antibodies labelled with 123I and 111In are used for the diagnosis of ovarian and breast cancer. Methods have been developed to label HMFG with 99mTc and this study reports on the subsequent radiation dose delivered. The 99mTc HMFG1 distribution was obtained in 5 normal female baboons up to 71 h after administration. The liver, kidneys, bladder and whole body were identified as source organs and total absorbed doses for the target organs were 0.054 (kidneys), 0.013 (liver), 0.140 (bladder), 0.010 (ovaria), 0.004 (bone marrow), 0.002 (thyroid), 0.003 (heart wall), 0.017 (uterus) and 0.005 mGy/MBq (whole body). The effective dose was 0.014 mSv/MBq.
Calitz
M M
MM
Department of Biophysics, University of the Orange Free State, Bloemfontein, Republic of South Africa.
Van Aswegen
A
A
Van Der Merwe
M M
MM
Lötter
M G
MG
D000042:Absorption; D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D005260:Female; D006801:Humans; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010215:Papio; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D015609:Organotechnetium Compounds