The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes.
CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a subpopulation of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12.
Virtaneva
K I
KI
Department of Genetics, University of Helsinki, Finland.
Angelisová
P
P
Baumruker
T
T
Horejsí
V
V
Nevanlinna
H
H
Schröder
J
J
D015703:Antigens, CD / Q000235:genetics*; D000943:Antigens, Differentiation / Q000235:genetics*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D000951:Antigens, Neoplasm; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins / Q000235:genetics*; D005810:Multigene Family; D011518:Proto-Oncogene Proteins; D060265:Tetraspanin 25; D059470:Tetraspanins
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; C059071:CD37 protein, human; C554894:CD53 protein, human; C497688:CD82 protein, human; D006023:Glycoproteins; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D060265:Tetraspanin 25; D059470:Tetraspanins