title: HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease.
abstract: OBJECTIVE
  To examine the distribution of HLA class II alleles in clinically distinct juvenile rheumatoid arthritis (JRA) subsets.
  
  
  METHODS
  We typed 298 patients and 181 controls for HLA-DRB1, DQA1, DQB1, and DPB1 alleles using polymerase chain reaction and oligonucleotide probe techniques.
  
  
  RESULTS
  Each JRA subset was characterized by a distinct distribution of HLA class II alleles. For the persistently pauciarticular and rheumatoid factor-negative polyarticular JRA subsets, certain combinations of DRB1 and DPB1 alleles were characteristic. In patients without antinuclear antibodies and chronic iridocyclitis, there was an increase of DRB1*0101/02 and DQA1*0101.
  
  
  CONCLUSIONS
  Findings of HLA typing support clinical subdivisions of the disease and suggest the existence of a novel DRB1*0101/02 and DQA1*0101 associated disease subset.
authors.affiliation: Institute of Transplantation Immunology, Oslo Sanitetsforenings Rheumatism Hospital, University of Oslo, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Ploski
authors.forename: O
authors.initials: O
authors.lastname: Vinje
authors.forename: K S
authors.initials: KS
authors.lastname: Rønningen
authors.forename: A
authors.initials: A
authors.lastname: Spurkland
authors.forename: D
authors.initials: D
authors.lastname: Sørskaar
authors.forename: F
authors.initials: F
authors.lastname: Vartdal
authors.forename: O
authors.initials: O
authors.lastname: Førre
mesh_terms: D000375:Aging / Q000235:genetics; D000483:Alleles; D000974:Antibodies, Antinuclear / Q000097:blood; D001171:Arthritis, Juvenile / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D015863:Iridocyclitis / Q000097:blood / Q000276:immunology; D008297:Male; D012307:Risk Factors
chemical_list: D000974:Antibodies, Antinuclear; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II