Quantitative electromyographic changes following modification of central dopaminergic transmission.
Muscle tone was assessed by measurement of quantitative electromyographic (EMG) activity recorded from electrodes chronically implanted in the gastrocnemius and anterior tibialis muscles of conscious, unrestrained rats. Following treatment with reserpine or denervation with 6-hydroxydopamine a significant increase in EMG activity of both muscles was observed, confirming the utility of the method for studying the effects of changes in central dopaminergic transmission on muscle tone.
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Department of Clinical Pharmacology, School of Medicine, Flinders University of South Australia, Bedford Park.
Crocker
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D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004576:Electromyography / Q000187:drug effects; D006614:Hindlimb; D008297:Male; D009121:Muscle Denervation; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology*; D009132:Muscles / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000494:pharmacology*
D012110:Reserpine; D016627:Oxidopamine; D001058:Apomorphine