title: Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease.
abstract: 99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietal-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demonstrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietal regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism.
authors.affiliation: Department of Neurology, University of Amsterdam, The Netherlands.
authors.forename: V I
authors.initials: VI
authors.lastname: Kwa
authors.forename: H C
authors.initials: HC
authors.lastname: Weinstein
authors.forename: E F
authors.initials: EF
authors.lastname: Posthumus Meyjes
authors.forename: E A
authors.initials: EA
authors.lastname: van Royen
authors.forename: L J
authors.initials: LJ
authors.lastname: Bour
authors.forename: P N
authors.initials: PN
authors.lastname: Verhoeff
authors.forename: B W
authors.initials: BW
authors.lastname: Ongerboer de Visser
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D004569:Electroencephalography / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D015609:Organotechnetium Compounds; D010091:Oximes; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime