Influence of cisplatinum on intestinal tolerance to photon and neutron irradiation in mice.
The hypothesis that cisplatinum (c-DDP) interacts with radiation by inhibiting the cellular repair capacities, was tested by comparing the interaction of c-DDP with low-LET (60Co gamma-rays) and high-LET radiation (d(50) + Be neutrons) in mice. The biological endpoint was lethality, 6 days after total body irradiation (early intestinal tolerance). The dose modifying factor was 1.80 +/- 0.25 for c-DDP plus 60Co gamma-rays, and 1.97 +/- 0.3 for c-DDP plus neutrons. As less repairable damage is induced by fast neutrons than by photons, this suggests that, in this system, the interaction between radiation and c-DDP is not explained by repair inhibition but is purely additive.
Lambin
P
P
Unité de Radiobiologie, Université Catholique de Louvain, Bruxelles, Belgium.
Scalliet
P
P
Coster
B
B
M'Vondo
J C
JC
Vynckier
S
S
Gueulette
J
J
Wambersie
A
A
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D007422:Intestines / Q000528:radiation effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009502:Neutrons; D011836:Radiation Tolerance / Q000187:drug effects*
D002945:Cisplatin