title: [Two cases of anaphylactoid reactions after intravenous methylprednisolone sodium succinate administration].
abstract: We have experienced two cases of anaphylactoid reactions following intravenous methylprednisolone sodium succinate administration. They had neither asthmatic nor other allergic histories. The first case was a 45-yr-old man. In addition to the antigenicity of hydrocortisone itself, it is suggested that administration speed was so fast that its side effects were intensified. The second case was a 10-yr old girl. Succinate ester was thought to be the cause of her allergic reaction (urticaria). It is also possible that her hypersensitivity to steroids was dose-dependent.
authors.affiliation: Department of Anesthesia, Niigata City Hospital.
authors.forename: I
authors.initials: I
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Ebine
authors.forename: C
authors.initials: C
authors.lastname: Koide
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D002648:Child; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D008776:Methylprednisolone Hemisuccinate