Tityus serrulatus scorpion venom toxins display a complex pattern of antigenic reactivity.
The antigenic properties of alpha-type and beta-type toxins purified from Tityus serrulatus (Ts) venom were analysed by radioimmunoassay, using rabbit antibodies raised against Ts VII, the main beta-type toxin in the venom, and against Ts IV, an alpha-type toxin. The anti-Ts VII serum did not recognize either the other beta-toxins Ts I and Ts II or the alpha-toxin Ts IV; the anti-Ts IV serum did not bind any of the three beta-toxins Ts I, Ts II or Ts VII. Thus, Tityus toxins display at least three distinct antigenic reactivity patterns.
De Lima
M E
ME
Departamento de Bioquimica e Immunologia, Instituto de Ciencias Biologicas, Belo Horizonte, M.G, Brazil.
Martin-Eauclaire
M F
MF
Chavez-Olortegui
C
C
Diniz
C R
CR
Granier
C
C
D000941:Antigens / Q000276:immunology*; D001667:Binding, Competitive; D003429:Cross Reactions; D011863:Radioimmunoassay; D012604:Scorpion Venoms / Q000276:immunology*
D000941:Antigens; D012604:Scorpion Venoms; C003609:tityustoxin