Coronary artery disease in patients with hearts from older donors: morphologic features and therapeutic implications.
Of 558 heart transplant recipients, 234 long-term survivors (more than 12 months) were studied by annual catheterization to evaluate the risk of postoperative coronary artery disease in hearts from older donors. No significant difference was found in graft function between hearts from younger and older donors (group I: n = 157, mean donor age 23 +/- 5 years, mean follow-up 45 +/- 22 months; group II: n = 77, mean donor age 43 +/- 5 years, mean follow-up 42 +/- 22 months) as indicated by left and right ventricular ejection fraction, pulmonary artery pressure, and pulmonary capillary wedge pressure. Two morphologic patterns of coronary artery disease were observed: a diffuse type of concentric narrowing of the arteries (type 1) and a focal type with proximal single-vessel stenosis (type 2). Type 1 occurred in eight patients (5%) in group I and in four patients in group II (5%) (p = not significant). Type 1 coronary artery disease led to graft failure in seven patients in group I and two patients in group II. Type 2 coronary artery disease occurred in seven patients (4%) in group I and in 14 (18%) in group II (p < 0.001). No death was related to graft failure in patients with type 2 coronary artery disease. Eight patients with type 2 coronary artery disease were successfully treated by percutaneous transluminal coronary angioplasty; one patient underwent coronary artery bypass grafting. Hearts from older donors provide normal graft function. The risk of diffuse coronary artery disease is not elevated in comparison to hearts from younger donors. The higher incidence of focal coronary artery disease suggests donor-transmitted disease that can successfully be treated by conventional therapy.
Schüler
S
S
German Heart Institute Berlin.
Matschke
K
K
Loebe
M
M
Hummel
M
M
Fleck
E
E
Hetzer
R
R
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015906:Angioplasty, Balloon, Coronary; D002648:Child; D002675:Child, Preschool; D017023:Coronary Angiography; D003327:Coronary Disease / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006084:Graft Rejection; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications; D014019:Tissue Donors; D016277:Ventricular Function, Left