title: Immediate sealing of arterial puncture sites after cardiac catheterization and coronary angioplasty using a biodegradable collagen plug: results of an international registry.
abstract: OBJECTIVE
  The aim of this study was to evaluate the safety and efficacy of a biodegradable collagen plug that has been developed to reduce the arterial compression time required to achieve hemostasis at the arterial puncture site after diagnostic and interventional coronary procedures.
  
  
  BACKGROUND
  After diagnostic and interventional coronary catheterization procedures, local arterial compression is required to achieve hemostasis and complications may ensue, especially in patients on full anticoagulation.
  
  
  METHODS
  Between March 1991 and July 1991, 252 patients admitted for routine coronary angiography or angioplasty to four large hospitals received such a hemostatic device immediately after the procedure. Hemostasis was achieved with collagen in 87% of patients after a mean compression time of 4.8 min. Time to hemostasis was independent of the heparin load. A total of 54 hematomas (21%) was reported; all but 2 resolved without additional treatment. Two patients had a severe hematoma, requiring blood transfusion, and two patients required surgery to repair a pseudoaneurysm. During a follow-up period of 4 weeks no severe late complications were reported.
  
  
  CONCLUSIONS
  We conclude that the collagen plug appears to be a safe device to achieve hemostasis at the arterial puncture site, independent of anticoagulation.
authors.affiliation: Department of Cardiology of St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: S M
authors.initials: SM
authors.lastname: Ernst
authors.forename: R M
authors.initials: RM
authors.lastname: Tjonjoegin
authors.forename: R
authors.initials: R
authors.lastname: Schräder
authors.forename: M
authors.initials: M
authors.lastname: Kaltenbach
authors.forename: U
authors.initials: U
authors.lastname: Sigwart
authors.forename: T A
authors.initials: TA
authors.lastname: Sanborn
authors.forename: H W
authors.initials: HW
authors.lastname: Plokker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D006328:Cardiac Catheterization; D003094:Collagen; D005260:Female; D005263:Femoral Artery; D006406:Hematoma / Q000453:epidemiology / Q000209:etiology; D006489:Hemostatic Techniques / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011677:Punctures / Q000009:adverse effects; D012042:Registries; D016896:Treatment Outcome
chemical_list: D003094:Collagen