Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors.
To investigate the dependence of the satiating action of cholecystokinin on serotonergic function in rats, we examined the effects of systemic pretreatment with serotonin (5-HT) antagonists of varying selectivity for 5-HT receptor subtypes on suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CCK-8). Mianserin, a 5-HT1C/2-selective antagonist, significantly attenuated the satiating action of CCK-8. Ketanserin, a 5-HT2 antagonist, and three 5-HT3 antagonists, MDL-72222, ICS 205-930, and ondansetron, however, had no effect on the satiating action of CCK-8. These results demonstrate that the satiating action of exogenous CCK depends on activation of 5-HT1 (probably 5-HT1C) receptors and that activation of 5-HT2 or 5-HT3 receptors is not required.
Poeschla
B
B
Department of Psychiatry, Cornell University Medical College, White Plains, New York.
Gibbs
J
J
Simansky
K J
KJ
Greenberg
D
D
Smith
G P
GP
D000818:Animals; D004435:Eating / Q000187:drug effects; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000502:physiology*; D012527:Satiation / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology; D012844:Sincalide / Q000494:pharmacology*; D014326:Tropanes / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; D008803:Mianserin; D007650:Ketanserin; D012844:Sincalide; C042253:bemesetron