Future directions of vitamin E and its analogues in minimizing myocardial ischemia-reperfusion injury.
Oxidant injury contributes to myocardial stunning, and cardiac ischemic and reperfusion injury. Vitamin E is the major--and perhaps the only--lipid soluble, chain-breaking antioxidant in the heart. Vitamin E and its analogues potentially offer significant advantages for the prevention of ischemic and reperfusion injury. Recent investigations have suggested that modified vitamin E analogues may be more efficacious than vitamin E and may permit myocardial salvage from acute myocardial ischemic injury.
Mickle
D A
DA
Department of Clinical Biochemistry, Toronto Hospital, Ontario.
Weisel
R D
RD
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002839:Chromans / Q000627:therapeutic use*; D016166:Free Radical Scavengers; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000975:Antioxidants; D002839:Chromans; D016166:Free Radical Scavengers; C067190:MDL 73404; D014810:Vitamin E; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid