Rat liver foci study on coexposure with 50 Hz magnetic fields and known carcinogens.
A study was performed to investigate possible interactions by magnetic fields (MF) with the processes of initiation and promotion of chemically induced preneoplastic lesions in rat liver. Male Sprague-Dawley rats were subjected to a 70% partial hepatectomy followed after 24 h by i.p. injection of diethylnitrosamine (DENA) as a tumour initiator. Starting one week after the DENA-treatment phenobarbital (PB) was given to promote growth of enzymatically altered foci of liver cells. MF was applied immediately after the partial hepatectomy and continued until sacrifice after 12 weeks of PB exposure. Homogenous horizontal AC magnetic fields with a frequency of 50 Hz and flux densities of 0.5 mu T or 0.5 mT were used. The rats coexposed with MF and DENA plus PB did not gain weight as much as the rats exposed to the chemical agents only. The MF-exposure also resulted in a slight reduction in size and numbers of the focal lesions. The results suggest an interaction of MF with the processes of chemical carcinogenesis either as a result of stress or depending on effects on the proliferation of preneoplastic cells.
Rannug
A
A
Department of Toxicology, National Institute of Occupational Health, Solna, Sweden.
Holmberg
B
B
Ekström
T
T
Mild
K H
KH
D000818:Animals; D002273:Carcinogens; D004574:Electromagnetic Fields / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens