Results of salvage mastectomy for local recurrence after breast-conserving surgery without radiation therapy.
BACKGROUND
Between 1975 and 1987, 128 patients with infiltrating breast cancer, categorized as clinical Stage I and II disease, were treated by breast conservation surgery without radiation therapy.


METHODS
After a median disease-free interval of 20 months (range, 8-64 months), 25 of 128 patients had local recurrence, for which salvage mastectomy was performed. The results of modified radial mastectomy as a salvage procedure were analyzed in these 25 patients.


RESULTS
After a median disease-free interval of 52 months (range, 8-75 years) after the salvage procedure, 12 patients had chest wall and distant recurrences, whereas 13 patients remained free of disease. The 5-year actuarial disease-free and overall survival rates after the salvage mastectomy were 51% and 65%, respectively.


CONCLUSIONS
Univariate analyses of factors affecting disease-free survival and overall survival showed that the size of the local recurrence (< or = 2 cm) (P = 0.009) and the number of pathologically positive axillary nodes at the time of the salvage procedure (fewer than four nodes) (P = 0.002) were associated with a better prognosis.
Cajucom
C C
CC
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263.
Tsangaris
T N
TN
Nemoto
T
T
Driscoll
D
D
Penetrante
R B
RB
Holyoke
E D
ED
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D015411:Mastectomy, Modified Radical / Q000401:mortality; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011379:Prognosis; D011878:Radiotherapy; D016879:Salvage Therapy; D015996:Survival Rate