IgA anti-dsDNA antibodies in systemic lupus erythematosus: occurrence, incidence and association with clinical and laboratory variables of disease activity.
The relationship between IgA anti-dsDNA antibodies and systemic lupus erythematosus (SLE) disease activity was investigated. IgA anti-dsDNA antibodies were measured using ELISA techniques. Elevated serum levels of IgA anti-dsDNA antibodies were detected in 51% of the patients with SLE (n = 57) and 8% of the diseased controls (n = 214). The presence of IgA anti-dsDNA antibodies was associated with kidney and joint abnormalities, with hypocomplementemia and with circulating immune complexes. We conclude that increased levels of IgA anti-dsDNA antibodies are associated with disease activity in patients with SLE.
Miltenburg
A M
AM
Department of Rheumatology, University Hospital Leiden, The Netherlands.
Roos
A
A
Slegtenhorst
L
L
Daha
M R
MR
Breedveld
F C
FC
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D004247:DNA / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012216:Rheumatic Diseases / Q000276:immunology
D000906:Antibodies; D007070:Immunoglobulin A; D004247:DNA