High-frequency phenotypic switching in Candida albicans.
Most strains of Candida albicans are capable of switching spontaneously and at high frequencies between a number of phenotypes distinguished by colony morphology. Unlike switching in many other microbial pathogens, switching in C. albicans is pleiotropic, affecting several morphological and physiological parameters. Recently, the first phase-specific genes were identified and shown to be regulated at the level of gene transcription.
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Department of Biological Sciences, University of Iowa, Iowa City 52242-1324.
Morrow
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Srikantha
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D000940:Antigenic Variation / Q000235:genetics*; D000946:Antigens, Fungal / Q000235:genetics*; D002176:Candida albicans / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity / Q000648:ultrastructure; D005656:Fungal Proteins / Q000096:biosynthesis / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D010641:Phenotype; D014158:Transcription, Genetic; D014774:Virulence
D000946:Antigens, Fungal; D005656:Fungal Proteins