Two distinct unit activity responses to morphine in the rostral ventromedial medulla of awake rats.
Past research investigating the rostral ventromedial medulla (RVM) in anesthetized animals has found two distinct classes of cells, ON and OFF, noted for their distinct responses to noxious stimuli and to morphine. However, only one class (ON) has been found in the awake animal paradigm. We report in this paper that we have found both the ON and OFF cell responses to morphine in the awake rat.
McGaraughty
S
S
Department of Psychology, University of Waterloo, Ont., Canada.
Reinis
S
S
Tsoukatos
J
J
D000818:Animals; D004558:Electric Stimulation; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D014851:Wakefulness
D009270:Naloxone; D009020:Morphine