title: Kinetic behaviour of zymogen activation processes in the presence of an inhibitor.
abstract: A global kinetic analysis of a general zymogen activation model, where not only the activating but also the activated enzyme suffer an irreversible inhibition is presented. A reaction in which the enzyme acts upon a substrate is coupled to monitor the process. In addition, we determined the corresponding kinetic equations for a number of particular cases of the general model studied. Finally, a kinetic data analysis and a procedure to discriminate among the different mechanisms considered, which are based on the kinetic equations obtained, are suggested.
authors.affiliation: Departamento de Química-Física, Escuela Universitaria Politécnica, Universidad de Castilla-La Mancha, Albacete, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Varón
authors.forename: M C
authors.initials: MC
authors.lastname: Manjabacas
authors.forename: M
authors.initials: M
authors.lastname: García-Moreno
authors.forename: E
authors.initials: E
authors.lastname: Valero
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Canovas
mesh_terms: D000595:Amino Acid Sequence; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007700:Kinetics; D008956:Models, Chemical; D008969:Molecular Sequence Data
chemical_list: D004792:Enzyme Precursors