The role of reactive oxygen species, antioxidants and phytopharmaceuticals in human immunodeficiency virus activity.
Currently, several prominent researchers are investigating the role of reactive oxygen and free radicals in the activation of latent HIV in infected individuals. Early clinical applications of free radical scavengers and plant-based antioxidant systems have shown promise of efficacy in altering this process. This manuscript demonstrates a premise for the existence of 'oxidative stress' as an important element in HIV progression and a basis for the use of these phytopharmaceutical substances.
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D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D000975:Antioxidants / Q000627:therapeutic use*; D016207:Cytokines / Q000502:physiology; D016166:Free Radical Scavengers; D005609:Free Radicals; D006678:HIV / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014775:Virus Activation
D000975:Antioxidants; D016207:Cytokines; D016166:Free Radical Scavengers; D005609:Free Radicals; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D010100:Oxygen