Carnitine action on neuromuscular disturbances in the fasting rat: potentiation by L-lysine.
L-Carnitine (oral route) significantly corrects the muscle hypocontractility and hypoexcitability induced in the rat after 5 consecutive days of fasting. This effect is interpreted on the basis of the dual role of L-carnitine as cofactor in the transport of long-chain fatty acids into the mitochondria and as a detoxifying agent of intracellular acyl-CoA. The activity of L-carnitine is increased with the concomitant administration (oral route) of an equimolar dose of L-lysine. In the present experimental conditions, there is a threefold potentiation by comparison with L-carnitine alone. This result is discussed on the basis of the combined effects of an exogenous supply of L-carnitine and endogenous synthesis of L-carnitine from the L-lysine administered at the same time.
Pierrefiche
G
G
Laboratoire d'Eutonologie, Hôpital Boucicaut, Paris, France.
Reynier
M
M
Laborit
H
H
D000284:Administration, Oral; D000818:Animals; D002331:Carnitine / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D005215:Fasting; D005227:Fatty Acids / Q000378:metabolism; D008239:Lysine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects
D005227:Fatty Acids; D008239:Lysine; D002331:Carnitine