Protection of Pasteurella multocida dermonecrotic toxin-challenged rats by toxoid-induced antibody.
Two different doses of glutaraldehyde-treated Pasteurella multocida dermonecrotic toxin (PMDT) were used to immunize rats. Rats developed serum IgG antibodies specific for native PMDT, and IgG titers increased with dose and number of toxoid immunizations. Survival rates in both active immunization and passive serum neutralization experiments were dependent on dose of toxoid vaccination and serum levels of anti-PMDT IgG. Vaccination with toxoid prevented weight loss but not leukocytosis and increased complement titers in toxin-challenged rats. Toxoid, itself, induced minimal leukocytosis but no alterations in complement titers or weight gain.
Pettit
R K
RK
U.S. Department of Agriculture, National Animal Disease Center, Avian Diseases Research Unit, Ames, IA.
Rimler
R B
RB
Ackermann
M R
MR
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D008297:Male; D010326:Pasteurella Infections / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000276:immunology*; D051381:Rats; D012222:Rhinitis, Atrophic / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014121:Toxoids / Q000008:administration & dosage / Q000276:immunology*
D000907:Antibodies, Bacterial; D014121:Toxoids