title: Minimal hypoxic pulmonary hypertension in normal Tibetans at 3,658 m.
abstract: Elevated pulmonary arterial pressure in high-altitude residents may be a maladaptive response to chronic hypoxia. If so, well-adapted populations would be expected to have pulmonary arterial pressures that are similar to sea-level values. Five normal male 22-yr-old lifelong residents of > or = 3,600 m who were of Tibetan descent were studied in Lhasa (3,658 m) at rest and during near-maximal upright ergometer exercise. We found that resting mean pulmonary arterial pressure [15 +/- 1 (SE) mmHg] and pulmonary vascular resistance (1.8 +/- 0.2 Wood units) were within sea-level norms and were little changed while subjects breathed a hypoxic gas mixture [arterial O2 pressure (PaO2) = 36 +/- 2 Torr]. Near-maximal exercise [87 +/- 13% maximal O2 uptake (VO2max)] increased cardiac output more than threefold to values of 18.3 +/- 1.2 l/min but did not elevate pulmonary vascular resistance. Breathing 100% O2 during near-maximal exercise did not reduce pulmonary arterial pressure or vascular resistance. We concluded that this small sample of healthy Tibetans with lifelong residence > or = 3,658 m had resting pulmonary arterial pressures that were normal by sea-level standards and exhibited minimal hypoxic pulmonary vasoconstriction, both at rest and during exercise. These findings are consistent with remarkable cardiac performance and high-altitude adaptation.
authors.affiliation: Department of Anthropology, University of Colorado, Denver.
authors.forename: B M
authors.initials: BM
authors.lastname: Groves
authors.forename: T
authors.initials: T
authors.lastname: Droma
authors.forename: J R
authors.initials: JR
authors.lastname: Sutton
authors.forename: R G
authors.initials: RG
authors.lastname: McCullough
authors.forename: R E
authors.initials: RE
authors.lastname: McCullough
authors.forename: J
authors.initials: J
authors.lastname: Zhuang
authors.forename: G
authors.initials: G
authors.lastname: Rapmund
authors.forename: S
authors.initials: S
authors.lastname: Sun
authors.forename: C
authors.initials: C
authors.lastname: Janes
authors.forename: L G
authors.initials: LG
authors.lastname: Moore
mesh_terms: D000328:Adult; D000531:Altitude; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D006328:Cardiac Catheterization; D002302:Cardiac Output / Q000187:drug effects; D002681:China; D015444:Exercise / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012146:Rest / Q000502:physiology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen