title: Toxicology of daily administration to mice of the radiation potentiator SR 4233 (WIN 59075).
abstract: We have investigated the feasibility of administration of an effective dose of the hypoxic cytotoxin, SR 4233, Monday-Friday daily for 6 weeks. From a thorough hematological, histopathological and clinical chemistry evaluation throughout the course and during a 3-week recovery period, we conclude that daily administration of a radiopotentiating dose of SR 4233 in mice is well tolerated and that bone marrow suppression is likely to be the dose-limiting toxicity.
authors.affiliation: Department of Radiation Oncology, Stanford University School of Medicine, CA 94305-5468.
authors.forename: J F
authors.initials: JF
authors.lastname: Spiegel
authors.forename: M A
authors.initials: MA
authors.lastname: Spear
authors.forename: J M
authors.initials: JM
authors.lastname: Brown
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000633:toxicity*; D000077704:Tirapazamine; D014227:Triazines / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D011838:Radiation-Sensitizing Agents; D014227:Triazines; D000077704:Tirapazamine