Epocarbazolins A and B, novel 5-lipoxygenase inhibitors. Taxonomy, fermentation, isolation, structures and biological activities.
New 5-lipoxygenase inhibitors, designated epocarbazolins A and B, were isolated from the culture broth of Streptomyces anulatus T688-8. These compounds showed potent rat 5-lipoxygenase inhibitory activity with weak antibacterial activity. Structural studies revealed that epocarbazolins are new carbazole antibiotics having a novel substitution pattern and an epoxide in the side chain.
Nihei
Y
Y
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Yamamoto
H
H
Hasegawa
M
M
Hanada
M
M
Fukagawa
Y
Y
Oki
T
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000145:classification*
D000900:Anti-Bacterial Agents; D002227:Carbazoles; D006893:Hydroxyeicosatetraenoic Acids; D016859:Lipoxygenase Inhibitors; C079808:epocarbazolin A; C079809:epocarbazolin B; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid