title: Severe limb abnormalities: analysis of a cluster of five cases born during a period of 45 days.
abstract: We report on 5 individuals with severe limb abnormalities born in our hospital within a period of 45 days. Detailed clinical descriptions, photographs, and radiographs are presented. Etiological evaluations included genetic background, obstetric history, invasive procedures during pregnancy, maternal infectious diseases or maternal hyperthermia, drug use before and during pregnancy, and occupational or recreational exposures of both parents.
authors.affiliation: Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands.
authors.forename: J N
authors.initials: JN
authors.lastname: van den Anker
authors.forename: E E
authors.initials: EE
authors.lastname: van Vught
authors.forename: G R
authors.initials: GR
authors.lastname: Zandwijken
authors.forename: T E
authors.initials: TE
authors.lastname: Cohen-Overbeek
authors.forename: D
authors.initials: D
authors.lastname: Lindhout
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000209:etiology; D015193:Chorionic Villi Sampling / Q000009:adverse effects; D016000:Cluster Analysis; D003042:Cocaine; D015331:Cohort Studies; D005145:Face / Q000002:abnormalities; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects; D007223:Infant; D017880:Limb Deformities, Congenital; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D019966:Substance-Related Disorders / Q000150:complications
chemical_list: D007093:Imidazoles; D003042:Cocaine; C009695:xylometazoline