title: Effects of dietary protein restriction on hemodynamics in chronic renal failure.
abstract: To elucidate the effect of protein and phosphorus restriction on hemodynamics in chronic renal failure, 14 patients were placed on a low-protein very-low-phosphorus diet (LPVLPD) and observed for metabolic and hemodynamic changes. For three weeks after initiation of the LPVLPD, the patients displayed a positive sodium balance in spite of dietary sodium restriction. During the fourth week, sodium balance decreased and approached zero. Sodium retention was accompanied by a significant decrease in plasma renin activity (P < 0.05) and mean blood pressure (P < 0.01), an increase in body weight (P < 0.05), a slight temporary decrease in hemoglobin (P < 0.05), hematocrit (P < 0.05) and total protein (P < 0.005), a negative nitrogen balance, and an increase in left ventricular ejection fraction (P < 0.01) and peak filling rate (P < 0.05). Serum creatinine concentration and endogenous creatinine clearance did not change during the experiment. These data indicate a role of dietary protein and phosphorus restriction in cardiac and fluid homeostasis in the pathophysiology of chronic renal failure.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shichiri
authors.forename: Y
authors.initials: Y
authors.lastname: Nishio
authors.forename: M
authors.initials: M
authors.lastname: Ogura
authors.forename: M
authors.initials: M
authors.lastname: Suenaga
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004039:Diet, Sodium-Restricted; D004044:Dietary Proteins / Q000008:administration & dosage*; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D016226:Phosphorus, Dietary / Q000008:administration & dosage; D012964:Sodium / Q000378:metabolism
chemical_list: D004044:Dietary Proteins; D016226:Phosphorus, Dietary; D012964:Sodium; D009584:Nitrogen