Radiotherapy after ovarian transposition: ovarian function and fertility preservation.
The outcome of ovarian function preservation and fertility after ovarian transposition was examined in women treated for cancer. Of 134 patients, 126 were treated with radiotherapy and 72 with chemotherapy. In a multivariate analysis, three factors appeared to be prognostic of ovarian castration: the age over 25, MOPP chemotherapy and a total dose to the ovaries higher than 5 Gy. The incidence of birth was lower in the general population but no abnormality was observed.
Haie-Meder
C
C
Institut Gustave Roussy, Service de Curiethérapie, Villejuif, France.
Mlika-Cabanne
N
N
Michel
G
G
Briot
E
E
Gerbaulet
A
A
Lhomme
C
C
Cosset
J M
JM
Sarrazin
D
D
Flamant
F
F
Hayat
M
M
D000293:Adolescent; D000328:Adult; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005298:Fertility / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies