Effects of etomidate on the adrenocortical and metabolic adaptation of the neonate.
The effects of etomidate on corticosteroid synthesis were compared with those of methohexitone. We studied 40 neonates, 22 delivered by elective and 18 by emergency Caesarean section. Apgar scores, blood sugar and plasma concentrations of cortisol and etomidate were evaluated at birth and 2 and 6 h postpartum. There was no difference in Apgar scores attributable to the induction agent. The median cortisol concentrations in cord blood were small (136 nmol litre-1; range 47-478 nmol litre-1, and 259 nmol litre-1; range 58-1504 nmol litre-1 after elective and emergency sections, respectively). During the study, cortisol concentrations increased in the infants in the methohexitone groups and decreased in those in the etomidate groups; this effect was most evident 2 h after delivery (methohexitone groups 245 nmol litre-1, range 70-959 nmol litre-1; etomidate groups 121 nmol litre-1, range 56-320 nmol litre-1). There was no difference at 6 h postpartum (methohexitone groups 183 nmol litre-1, range 25-756 nmol litre-1; etomidate groups 190 nmol litre-1, range 33-628 nmol litre-1). The concentration changes during the study period differed significantly (P < 0.005) with respect to the induction agent. Blood glucose concentrations were small (mean (SD) in all 40 neonates 2 h postpartum was 2.64 (0.77) mmol litre-1), and did not differ between the groups. There were 17 cases of moderate to severe hypoglycaemia (blood glucose concentrations less than 2.5 mmol litre-1): nine in the etomidate group and eight in the methohexitone group.(ABSTRACT TRUNCATED AT 250 WORDS)
Crozier
T A
TA
Department of Anaesthesiology, University of Göttingen, Federal Republic of Germany.
Flamm
C
C
Speer
C P
CP
Rath
W
W
Wuttke
W
W
Kuhn
W
W
Kettler
D
D
D000773:Anesthesia, Obstetrical; D001786:Blood Glucose / Q000378:metabolism*; D002585:Cesarean Section; D003864:Depression, Chemical; D005045:Etomidate / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007231:Infant, Newborn / Q000097:blood*; D008723:Methohexital / Q000494:pharmacology; D011247:Pregnancy; D013997:Time Factors
D001786:Blood Glucose; D008723:Methohexital; D006854:Hydrocortisone; D005045:Etomidate