Pharmacologic management of neonatal cerebral ischemia and hemorrhage: old and new directions.
New developments in pharmacologic management of cerebral ischemia and hemorrhage are reviewed. A number of agents with diverse modes of action have now been shown to be neuroprotective in adult and neonatal animal models when administered either before or after a hypoxic-ischemic insult. As experience improves with these agents in hypoxic-ischemic injury and periventricular-intraventricular hemorrhage in human neonates, there is reason to be optimistic that effective neuroprotective strategies will soon be clinically available.
Miller
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VS
Division of Pediatric Neurology, University of Texas Southwestern Medical School, Dallas 75235.
D001925:Brain Damage, Chronic / Q000401:mortality / Q000517:prevention & control; D002545:Brain Ischemia / Q000188:drug therapy* / Q000401:mortality; D002491:Central Nervous System Agents / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy / Q000401:mortality; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000401:mortality
D002491:Central Nervous System Agents