Reduction of bacterial titers by low-dose aspirin in experimental aortic valve endocarditis.
Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial titer of the vegetations.
Nicolau
D P
DP
Department of Pharmacy, Hartford Hospital, Connecticut 06115.
Freeman
C D
CD
Nightingale
C H
CH
Quintiliani
R
R
Coe
C J
CJ
Maderazo
E G
EG
Cooper
B W
BW
D000818:Animals; D001021:Aortic Valve / Q000382:microbiology; D001241:Aspirin / Q000627:therapeutic use*; D001422:Bacterial Adhesion / Q000187:drug effects; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D011817:Rabbits; D013211:Staphylococcus aureus
D001241:Aspirin