Solid-state nuclear magnetic resonance (NMR) spectra of pharmaceutical dosage forms.
Solid-state 13C NMR spectra of tablets or capsules of prednisolone, enalapril maleate, lovastatin, simvastatin, ibuprofen, flurbiprofen, mefenamic acid, indomethacin, diflunisal, sulindac, and piroxicam were obtained in the CP/MAS mode at 50 MHz. These studies show that (1) solid-state NMR spectroscopy can detect the active ingredients in low-dose tablets and capsules; (2) the use of interrupted decoupling often results in suppression of resonances due to excipients, thereby allowing better detection of resonances from the drug; and (3) the technique permits discrimination between two prednisolone polymorphs present in tablets obtained from various manufacturers even though the tablets contain only approximately 5% (w/w) of the drug.
Saindon
P J
PJ
Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907.
Cauchon
N S
NS
Sutton
P A
PA
Chang
C J
CJ
Peck
G E
GE
Byrn
S R
SR
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis; D002214:Capsules / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004656:Enalapril / Q000032:analysis; D008148:Lovastatin / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D011239:Prednisolone / Q000032:analysis; D012995:Solubility; D013607:Tablets / Q000032:analysis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D013607:Tablets; D004656:Enalapril; D008148:Lovastatin; D011239:Prednisolone