Phenol anesthesia of the tympanic membrane in purulent otitis media: a structural analysis in the rat.
In the present study, local anesthetics were applied to the tympanic membrane (TM) of rats following experimentally evoked purulent otitis media (POM). The structure of the TM was evaluated 24 h, 2 weeks and 3 months after application of phenol to a discrete are of the right TM. The left ear was used as a control. POM induced swelling of all tissue layers of the pears tensa. The tissues were invaded by inflammatory cells and disintegrated. The fibrous layer also dissolved, leaving spontaneous perforations. However, phenol on inflamed TMs did not further alter the TM structure. These findings infer that the injurious effect of topical anesthesia on the intact TM is more or less negligible when applied to diseased TMs.
Schmidt
S H
SH
Department of Otorhinolaryngology & Head and Neck Surgery, University of Umeå, Sweden.
Hellström
S
S
D000772:Anesthesia, Local; D000818:Animals; D008297:Male; D010035:Otitis Media, Suppurative / Q000473:pathology*; D019800:Phenol; D010636:Phenols / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014432:Tympanic Membrane / Q000187:drug effects / Q000473:pathology*
D010636:Phenols; D019800:Phenol