Anthelmintic activity of pyrazinothiadiazine dioxide derivatives.
In a search for new anthelmintic compounds, some pyrazinothiadiazine dioxide derivatives were synthesized. Their anthelmintic activity was tested against larva and preadult stages of Trichinella spiralis. The mode of action and acute toxicity of these compounds were investigated. Structure-activity relationships are discussed.
Herrero
A
A
Instituto de Química Médica, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
Ochoa
C
C
Pérez
C
C
Rodríguez-Caabeiro
F
F
Jiménez
A
A
de Armas
C
C
Criado
A
A
Font
M
M
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002645:Chickens; D003078:Colchicine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005493:Folic Acid Antagonists; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D011485:Protein Binding / Q000187:drug effects; D011719:Pyrazines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D013329:Structure-Activity Relationship; D014234:Trichinella / Q000187:drug effects; D014235:Trichinellosis / Q000188:drug therapy / Q000469:parasitology; D014404:Tubulin / Q000187:drug effects / Q000378:metabolism
D000871:Anthelmintics; D005493:Folic Acid Antagonists; D011719:Pyrazines; D014404:Tubulin; D003078:Colchicine