title: Spectrum of poisoning requiring haemodialysis in a tertiary care hospital in India.
abstract: We report our experience in 66 cases of acute poisoning requiring haemodialysis (HD) in the last 17 years. Barbiturate poisoning was the commonest poisoning (30 cases). Mean blood barbiturate level was 8.9 mg%. Twenty four were in grade IV coma at the time of presentation. Twenty five required one HD and 5 cases needed 2 HD. Four died due to respiratory infection or hypotension. Copper sulphate poisoning was encountered in 19 cases. Common features in this group were: acute renal failure (ARF) (19), haematuria (3), gastrointestinal bleeding (7), intravascular haemolysis (9), jaundice (11), hepatocellular toxicity (8), methaemoglobinuria (8) and circulatory collapse (5). The indication for HD in all these cases was ARF. Seven patients died. There were 9 cases of mercuric chloride poisoning requiring 2-5 HD. Common features in this group were; ARF (9), gastrointestinal bleeding (9), anaemia (8), jaundice (2). Two patients died. Other patients had Mandrax, Naphthalene, Tincture Iodine, Ethylene Bromide and Lithium poisoning. Overall mortality in our study was 24.2%. It is concluded that HD is not the primary mode of therapy for drug intoxication. Adequate supportive management is most important in determining final outcome of these patients.
authors.affiliation: Department of Nephrology, All India Institute of Medical Sciences, New Delhi.
authors.forename: S K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: S C
authors.initials: SC
authors.lastname: Tiwari
authors.forename: S C
authors.initials: SC
authors.lastname: Dash
mesh_terms: D001463:Barbiturates / Q000506:poisoning*; D003300:Copper / Q000506:poisoning; D019327:Copper Sulfate; D004155:Diphenhydramine / Q000506:poisoning; D004338:Drug Combinations; D015946:Ethylene Dibromide; D006801:Humans; D007194:India; D007455:Iodine / Q000506:poisoning; D008094:Lithium / Q000506:poisoning; D008627:Mercuric Chloride / Q000506:poisoning; D008702:Methaqualone / Q000506:poisoning; D009281:Naphthalenes / Q000506:poisoning; D011041:Poisoning / Q000628:therapy*; D006435:Renal Dialysis
chemical_list: D001463:Barbiturates; D004338:Drug Combinations; D009281:Naphthalenes; D015946:Ethylene Dibromide; C031721:naphthalene; D008627:Mercuric Chloride; D003300:Copper; D008702:Methaqualone; C005188:Mandrax; D004155:Diphenhydramine; D007455:Iodine; D008094:Lithium; D019327:Copper Sulfate