title: Effect of ethanol on metabolic responses to treadmill running in well-trained men.
abstract: The metabolic effects of ethanol on treadmill performance were determined in four trained runners. Ethanol in doses of 25 mL in 150 mL of grapefruit juice (total volume) or grapefruit juice was randomly administered 10 minutes before and at 30 minutes of a 60-minute treadmill run. The speed and grade of the treadmill was adjusted to elicit an average oxygen consumption (VO2) of 80 to 85% of the subjects' VO2max. Three of the four subjects could not complete the treadmill run after the administration of ethanol. Administration of ethanol resulted in significant increases in the heart rate responses to treadmill running above those for the placebo grapefruit treatment. VO2 was higher after ethanol administration than the placebo grapefruit juice treatment, but these values were not significant. Blood glucose content rose significantly between 0 and 30 minutes of treadmill running for both the ethanol and placebo grapefruit juice treatments. Between 30 minutes of treadmill running and the termination of the exercise, the blood glucose level decreased significantly by 24% after the second ethanol treatment at 30 minutes of exercise. Plasma fatty acid, triglyceride, creatine phosphokinase, and renin contents followed expected exercise changes. It was concluded that the administration of ethanol adversely influenced treadmill exercise performance by eliciting a hypoglycemic effect between 30 minutes and the termination of the exercise.
authors.affiliation: Biokinetics Research Laboratory, HPERD College, Temple University, Philadelphia, Pennsylvania 19122.
authors.forename: Z V
authors.initials: ZV
authors.lastname: Kendrick
authors.forename: M B
authors.initials: MB
authors.lastname: Affrime
authors.forename: D T
authors.initials: DT
authors.lastname: Lowenthal
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005080:Exercise Test / Q000187:drug effects*; D005227:Fatty Acids / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D010101:Oxygen Consumption; D010809:Physical Fitness; D012083:Renin / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D014280:Triglycerides; D000431:Ethanol; D003402:Creatine Kinase; D012083:Renin