title: Antitumor effect of chemically synthesized (+)-goniopypyrone.
abstract: Chemically synthesized (+)-goniopypyrone was found to suppress the growth of cultured Ehrlich ascites tumor cells as well as PU5-1.8 cells. The ED50 values were found to be 35 and 30 micrograms/ml for the two cell lines used. An LD50 of 193 micrograms/ml was observed in the brine shrimp bioassay.
authors.affiliation: Department of Chemistry, Chinese University of Hong Kong, Shatin, N.T.
authors.forename: T K
authors.initials: TK
authors.lastname: Shing
authors.forename: M
authors.initials: M
authors.lastname: Look
authors.forename: Y M
authors.initials: YM
authors.lastname: Choy
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002460:Cell Line; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000494:pharmacology*; D013343:Styrenes / Q000138:chemical synthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D013343:Styrenes; C080434:goniopypyrone