title: Renal potassium wasting in the absence of aldosterone. Insights into the mechanism for the secretion of potassium.
abstract: This report focuses on the possible pathophysiology of a renal lesion that led to hypokalemia and the excessive excretion of potassium (K+) in a 2.5-year-old child. The rate of excretion of K+ was high, largely the result of forces leading to a very high concentration of K+ in the lumen of the terminal cortical collecting duct as revealed by very high values for the transtubular K+ concentration gradient (TTKG was 25 +/- 3). The TTKG was high despite undetectable levels of aldosterone in plasma and the absence of bicarbonaturia. The level of renin in plasma was not low and there was a tendency to contraction of the ECF volume when dietary intake was curtailed. These findings provided the basis to speculate that the underlying lesion might be a lower than normal 'permeability' of the cortical collecting duct for chloride.
authors.affiliation: Renal Divisions, Hospital for Sick Children, Toronto, Ont., Canada.
authors.forename: D
authors.initials: D
authors.lastname: Scolnik
authors.forename: M L
authors.initials: ML
authors.lastname: Halperin
mesh_terms: D000450:Aldosterone / Q000097:blood; D002675:Child, Preschool; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D007008:Hypokalemia / Q000209:etiology / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D002712:Chlorides; D000450:Aldosterone; D011188:Potassium