c-myc oncogene expression in estrogen-dependent and -independent breast cancer.
We demonstrate that c-myc gene expression is essential for growth of breast cancer cells. It also plays an important role in the progression of human breast cancer. c-myc gene amplification may be important for cancer cell invasion, but perhaps not essential for nodal metastasis. We also provide compelling evidence that the c-myc oncogene is an estrogen target gene in hormone-responsive breast cancer. Hormonal progression of breast cancer could be brought about by the enhanced expression of the c-myc gene, with gene amplification and enhanced c-myc mRNA stability being two major mechanisms involved.
Shiu
R P
RP
Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Watson
P H
PH
Dubik
D
D
D001943:Breast Neoplasms / Q000235:genetics*; D004967:Estrogens / Q000494:pharmacology*; D005784:Gene Amplification; D015870:Gene Expression; D016259:Genes, myc / Q000235:genetics*; D006801:Humans
D004967:Estrogens