[Folic acid and vitamin B12 in children under long-term anticonvulsant therapy].
Folic acid (FA) and vitamin B12 have been measured prospectively in 110 children that were under treatment with anticonvulsants. The control group consisted of 59 healthy children. A statistically significant difference in levels of serum FA and mean corpuscular volume (MCV) was observed between groups. Children under anticonvulsant treatment had lower serum FA levels and higher MCV. No significant difference was observed between the two groups in levels of serum vitamin B12. All children with serum FA levels lower than 3 ng/ml were given folate and no adverse side effects were observed due to treatment. Anticonvulsant drugs decrease serum FA levels; therefore, FA should be determined periodically in children under long-term anticonvulsant treatment.
Porras Tejero
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Departamento de Pediatría, Hospital Universitario Virgen Macarena, Sevilla.
Lluch Fernández
M D
MD
D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood*; D005494:Folic Acid Deficiency / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008134:Long-Term Care; D008297:Male; D014805:Vitamin B 12 / Q000097:blood*
D000927:Anticonvulsants; D005492:Folic Acid; D014805:Vitamin B 12