title: Immune response against lipopolysaccharide and invasion plasmid-coded antigens of shigellae in Vietnamese and Swedish dysenteric patients.
abstract: The peripheral immune responses of adult Vietnamese patients infected with Shigella dysenteriae 1 and Shigella flexneri 1b and 2a and those of S. flexneri-infected Swedish patients were studied against various lipopolysaccharide and invasion plasmid-coded antigens (Ipa-s) and compared with the titers for the corresponding local healthy populations. Both Vietnamese and Swedish patients reacted with significant (P, < 0.05) titer increases in the immunoglobulin A and G classes against the homologous lipopolysaccharide antigen. However, significant titer responses against the Ipa-s were seen among only the Swedish patients. We surmise that the weak-to-moderate responses against the Ipa-s in Vietnamese patients are due to the fact that the high level of titers induced by previous infections in the local population could not be considerably increased further by a recent infection.
authors.affiliation: Department of Clinical Bacteriology, Karolinska Institute, Huddinge Hospital, Sweden.
authors.forename: P D
authors.initials: PD
authors.lastname: Cam
authors.forename: T
authors.initials: T
authors.lastname: Pál
authors.forename: A A
authors.initials: AA
authors.lastname: Lindberg
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000235:genetics; D004405:Dysentery, Bacillary / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D010957:Plasmids; D012760:Shigella / Q000235:genetics / Q000276:immunology*; D013548:Sweden; D014744:Vietnam
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D008070:Lipopolysaccharides