Cloning and structural analysis of genomic DNA for human renal dipeptidase.
A genomic DNA for human renal dipeptidase was isolated from a human genomic library using probes for human renal dipeptidase cDNA. The human renal dipeptidase gene, containing ten exons and nine introns, had a total length of approx. 6 kbp. The DNA sequence of these exons was slightly different from that of the human renal dipeptidase cDNA reported by Adachi et al. [1]. From the results of a comparison of the deduced amino acid sequence of each exon with various mammalian renal dipeptidases, the fourth exon was found to be highly conserved (90%).
Satoh
S
S
Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
Kusunoki
C
C
Konta
Y
Y
Niwa
M
M
Kohsaka
M
M
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D004150:Dipeptidases / Q000235:genetics*; D005091:Exons; D015698:Genomic Library; D006801:Humans; D007668:Kidney / Q000201:enzymology*; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D016385:TATA Box
D004247:DNA; D004150:Dipeptidases