title: Acute effects of cicletanine in angina pectoris.
abstract: The anti-anginal properties of single doses of a new anti-hypertensive drug, cicletanine, were investigated in a double-blind, randomised, balanced, crossover comparison with placebo in sixteen patients with chronic stable angina pectoris. All subjects underwent treadmill exercise 2 h after drug administration and 24 h ambulatory ECG monitoring with ST scanning. Although there were significantly fewer episodes of ST depression on ambulatory monitoring after cicletanine, total exercise duration and time to 1 mm ST depression were unchanged. This report provides little evidence of an acute anti-anginal effect of cicletanine but longer term studies may be indicated to further evaluate this drug's potential role in the management of angina pectoris.
authors.affiliation: University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK.
authors.forename: D L
authors.initials: DL
authors.lastname: Murdoch
authors.forename: E
authors.initials: E
authors.lastname: Henderson
authors.forename: H J
authors.initials: HJ
authors.lastname: Dargie
authors.forename: G T
authors.initials: GT
authors.lastname: McInnes
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D017079:Exercise Tolerance / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000627:therapeutic use*
chemical_list: D011725:Pyridines; C038068:cicletanine