The transfer of cocaine and its metabolites across the term human placenta.
This study defines human placental transport of cocaine and its two minor, but pharmacologically active, metabolites--norcocaine and cocaethylene. The experimental system was the single, isolated perfused cotyledon of a normal term human placenta, and antipyrine served as a freely diffusible marker. Cocaine was transferred rapidly by the placenta at a rate about 80% that of antipyrine. The transfer had characteristics of passive transport consistent with the high lipid solubility of the drug. We found no evidence of significant placental metabolism of cocaine during its rapid placental transfer. Ethanol did not alter the cocaine transfer rate. Norcocaine and cocaethylene were equally as rapidly transferred. Thus the placenta is no barrier to the transfer of cocaine and its derivatives to the fetus.
Schenker
S
S
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7878.
Yang
Y
Y
Johnson
R F
RF
Downing
J W
JW
Schenken
R S
RS
Henderson
G I
GI
King
T S
TS
D001692:Biological Transport; D003042:Cocaine / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
C008671:norcocaine; C066444:cocaethylene; D003042:Cocaine