The non-depolarizing D-form of bromohomoibotenic acid enhances depolarizations evoked by the L-form or quisqualate.
The D-enantiomer of bromohomoibotenic acid (Br-HIBO) was inactive in electrophysiological experiments when administered alone, but enhanced depolarizations evoked by L-Br-HIBO or quisqualate when co-administered with these agonists. In addition, quisqualate induced a long-lasting (> 120 min) sensitization of cortical wedge neurons to D-Br-HIBO. This latter effect of D-Br-HIBO was similar to, but significantly more potent and selective, than the earlier observed quisqualate-induced sensitization of cortical neurones to depolarization by (S)-2-amino-4-phosphonobutyric acid (L-AP4).
Madsen
U
U
Department of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen.
Ebert
B
B
Hansen
J J
JJ
Krogsgaard-Larsen
P
P
D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects; D004594:Electrophysiology; D007051:Ibotenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D016318:Quisqualic Acid / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism
D000613:Aminobutyrates; C023366:4-bromohomoibotenic acid; D007051:Ibotenic Acid; D016318:Quisqualic Acid; C012729:2-amino-4-phosphonobutyric acid