[Hyperandrogenism in hirsute and obese women. Effects of a low calorie diet].
To investigate the relationship between overweight and hyperandrogenism, a 1500 kcal/day diet was prescribed for 4 months to 23 hirsute and obese patients. This diet decreased body mass index from 29.9 +/- 4.9 to 27.2 +/- 4.4 kg/m2 (P < 0.008), but had no significant effect on fasting insulin levels (18.9 +/- 14.2 vs. 21.1 +/- 9.6 mlU/l). Weight lost increased significantly (P < 0.008) the plasma concentration of sex-hormone binding-globulin (SHBG) from 21.2 +/- 10.6 to 26.2 +/- 13.5 nmol/l and decreased significantly (P < 0.04) the SHBG-unbound testosterone concentration from 9.3 +/- 6.2 to 7.2 +/- 4.8 ng/dl, without changing the concentrations of the main androgens measured in this study. Moreover, during diet 5 patients in amenorrhea and 8 among 13 patients with irregular menstrual cycle recovered regular menses. We concluded that the control of excess body weight in hirsute women is effective but not sufficient to improve hyperandrogenism.
Nicolas
M H
MH
Laboratoire de la Clinique endocrinologique, Hôpital de l'Antiquaille, Lyon.
Crave
J C
JC
Fimbel
S
S
Siméan
A
A
Pugeat
M
M
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000178:diet therapy / Q000209:etiology; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D006628:Hirsutism / Q000150:complications / Q000178:diet therapy*; D006801:Humans; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000150:complications / Q000178:diet therapy*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*; D015431:Weight Loss
D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D003687:Dehydroepiandrosterone
Hyperandrogénie de la femme hirsute et obèse. Effets d'un régime hypocalorique.