Role of the CD45 tyrosine phosphatase in signal transduction in the immune system.
CD45, a family of hematopoietic cell specific surface antigens, is the best characterized protein tyrosine phosphatase described to date. Considerable evidence from a number of laboratories suggests that surface expression of this molecule is required for normal signaling events to occur in T lymphocytes, B lymphocytes, and natural killer cells. In this paper, data supporting this contention are reviewed and a model proposing how CD45 may exert its regulatory function on signal transduction via the T cell antigen receptor is presented.
Koretzky
G A
GA
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
D000818:Animals; D006801:Humans; D007107:Immune System / Q000502:physiology*; D017493:Leukocyte Common Antigens / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
D017493:Leukocyte Common Antigens