Growth hormone treatment after abdominal surgery decreased carbohydrate oxidation and increased fat oxidation in patients with total parenteral nutrition.
Patients undergoing elective abdominal surgery were double-blindly randomized for treatment with growth hormone (GH) 24 IU (n = 9) or placebo (n = 10) the first 5 postoperative days while receiving total parenteral nutrition (nitrogen, 5.7 +/- .1 g/m2; energy, 1,018 +/- 12 kcal/m2, ie, 125% +/- .7% of basal metabolic rate [BMR]). Carbohydrate and fat metabolism were evaluated from indirect calorimetry, daily blood samples, and forearm substrate-flux studies. Hormone levels in plasma or blood were also determined. GH decreased carbohydrate oxidation, increased fat oxidation, and increased resting energy expenditure (REE). Free fatty acids (FFA), glycerol, and beta-hydroxybutyrate (beta-OH-B) levels increased in both arterial and venous plasma, and forearm release of FFA and glycerol increased. GH, insulin-like growth factor 1 (IGF-1), and glucagon levels in venous blood were also increased in GH-treated patients. Thus, GH induced mobilization and utilization of fat, and fat was preferred to glucose for energy requirements in patients after abdominal surgery with nutritional support.
Mjaaland
M
M
Department of Surgery, Tromsø University Hospital, Norway.
Unneberg
K
K
Bjøro
T
T
Revhaug
A
A
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002151:Calorimetry; D013505:Digestive System Surgical Procedures; D004311:Double-Blind Method; D005260:Female; D005542:Forearm / Q000098:blood supply; D005947:Glucose / Q000378:metabolism*; D013006:Growth Hormone / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010289:Parenteral Nutrition, Total; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D011994:Recombinant Proteins / Q000627:therapeutic use
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D011994:Recombinant Proteins; D019344:Lactic Acid; D019289:Pyruvic Acid; D013006:Growth Hormone; D005947:Glucose