[Metabolic regulation on retinoic acid and vitamin E function].
1. Retinoic acid is an oxidative metabolite which is produced intracellularly and plays role in gene expression via nuclear retinoic acid receptor (RAR), a family of steroid receptor. Recently, clinical use of retinoic acid in acute pro-myelocytic leukemia (APL) was proposed to induce complete remission in the leukemic cells, which have the t(15:17) of chromosomal anomaly producing a different protein from the normal RAR. From this clinical view, the regulatory role of retinoic acid is becoming clear in the cells. 2. Vitamin E is an antioxidant in biological membranes to prevent from their oxidative chain reaction occurring near the location of vitamin E in the lipid layer of the membranes. Thus, the location of vitamin E, especially alpha-tocopherol differing from the other analogues, in the living body is important to assess its function. From the standpoint of view, absorption of vitamin E from the gut, its circulation in the blood, and transportation to tissues and cells will be discussed in this paper.
Mino
M
M
Osaka Medical College.
D006801:Humans; D014212:Tretinoin / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism / Q000502:physiology*
D014810:Vitamin E; D014212:Tretinoin