Suppression of ADCC by immune complexes formed in vitro in Mycobacterium leprae-infected mice.
Antibody-dependent cellular cytotoxicity (ADCC) was assessed in mice infected experimentally with Mycobacterium leprae and injected simultaneously with in vitro-formed immune complexes (IC). Significant decrease in the ADCC function was observed in animals given IC at zero day (0dIC) and 3 months (3mIC) post inoculation with M. leprae, when ADCC activity was assessed at 3, 6 and 9 months period. From the data obtained we believe that ADCC is suppressed by IC formed in vitro.
Vaishnavi
C
C
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ganguly
N K
NK
Kaur
S
S
Kumar
B
B
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D000936:Antigen-Antibody Complex / Q000096:biosynthesis*; D015169:Colony Count, Microbial; D007108:Immune Tolerance; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology; D007918:Leprosy / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D009166:Mycobacterium leprae / Q000276:immunology / Q000302:isolation & purification; D013997:Time Factors
D000936:Antigen-Antibody Complex