Treatment of vasculogenic sexual dysfunction with pentoxifylline.
OBJECTIVE
To evaluate the use of pentoxifylline to treat impotence in men with mild to moderate penile vascular insufficiency.


METHODS
Double-blind randomized clinical trial.


METHODS
Sexual Dysfunction Clinic at VA Medical Center, Sepulveda, CA.


METHODS
Convenience sample of couples.


METHODS
Twelve weeks of treatment with placebo or 400 mg tid of pentoxifylline.


METHODS
(1) Report of patient verified by partner as to number of coital episodes per month; (2) penile-brachial pressure index determinations.


RESULTS
Pentoxifylline therapy regularly increased the PBPI in impotent men in comparison with the placebo, frequently into the normal range. Pentoxifylline therapy was particularly useful in restoring the PBPI in men with the pelvic steal syndrome; six of seven such subjects improved into the normal range. During the pentoxifylline treatment period, in contrast with the control period, nine men were able to reestablish coital function and three had no improvement. Six couples did not attempt intercourse despite a professed interest in sexual activity; however five out of the six men experienced erections during episodes of fantasy or attempts at masturbation during treatment. There were no complications of therapy.


CONCLUSIONS
These promising preliminary results suggest a well tolerated alternative therapy for erectile dysfunction in patients with mild to moderate penile vascular disease.
Korenman
S G
SG
Department of Medicine, UCLA, School of Medicine 90024.
Viosca
S P
SP
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000175:diagnosis; D001161:Arteriosclerosis / Q000150:complications; D001794:Blood Pressure / Q000187:drug effects; D001916:Brachial Artery; D003075:Coitus; D015897:Comorbidity; D048909:Diabetes Complications; D004311:Double-Blind Method; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010413:Penis / Q000098:blood supply*; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D007986:Luteinizing Hormone; D010431:Pentoxifylline