title: Microbial hydroxylation of (-)-eburnamonine by Mucor circinelloides and Streptomyces violens.
abstract: (6R)-6-Hydroxy-, (6S)-6-hydroxy- and (18S)-18-hydroxyeburnamonines were obtained by microbial conversion of (-)-eburnamonine using Mucor circinelloides and Streptomyces violens. Their structures were determined by analyses of the mass, 1H- and 13C-NMR spectra. (-)-Eburnamonine and the three hydroxylated compounds showed cerebral protecting effects against potassium cyanide intoxication in mice.
authors: Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors: T
authors: T
authors: Adachi
authors: M
authors: M
authors: Saito
authors: J
authors: J
authors: Sasaki
authors: Y
authors: Y
authors: Karasawa
authors: H
authors: H
authors: Araki
authors: K
authors: K
authors: Hanada
authors: S
authors: S
authors: Omura
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009089:Mucor / Q000378:metabolism*; D011190:Potassium Cyanide / Q000633:toxicity; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*; D014665:Vasodilator Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D014748:Vinca Alkaloids; D011190:Potassium Cyanide; C016422:eburnamonine