Intestinal parasites and HIV infection in Tanzanian children with chronic diarrhea.
OBJECTIVE
To determine whether specific intestinal parasites are associated with HIV infection in Tanzanian children with chronic diarrhea.


METHODS
A prospective, cross-sectional study.


METHODS
Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.


METHODS
All children aged 15 months to 5 years admitted with chronic diarrhea, and age-matched controls.


METHODS
Standardized history, physical examination, HIV serology, and stool parasitology were evaluated for all subjects. We compared three groups: HIV-infected and non-HIV-infected children with chronic diarrhea and controls without diarrhea.


METHODS
Fecal parasites and nutritional status.


RESULTS
Chronic diarrhea accounted for one-quarter of all cases of diarrheal disease in the defined age range, and children with chronic diarrhea were severely malnourished. Forty per cent of subjects with chronic diarrhea were HIV-seropositive. Although intestinal parasites were detected in approximately 50% of all three groups, diarrheagenic parasites were detected in up to 40% of children with chronic diarrhea. Blastocystis hominis was detected only in HIV-infected patients.


CONCLUSIONS
HIV infection was common in children with chronic diarrhea, and parasitic agents of diarrhea may be important in children with chronic diarrhea both with and without HIV infection in this setting. B. hominis was more frequent in HIV-infected children. The immunocompromising effects of severe malnutrition may have diminished the difference between HIV-infected and non-HIV-infected children.
Cegielski
J P
JP
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Msengi
A E
AE
Dukes
C S
CS
Mbise
R
R
Redding-Lallinger
R
R
Minjas
J N
JN
Wilson
M L
ML
Shao
J
J
Durack
D T
DT
D002675:Child, Preschool; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003967:Diarrhea / Q000150:complications* / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007411:Intestinal Diseases, Parasitic / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D013636:Tanzania / Q000453:epidemiology