Comparative effect of nifedipine and S-adenosylmethionine, singly and in combination on experimental rat liver cirrhosis.
An experimental rat liver cirrhosis, by means of carbon tetrachloride and ethanol during 8 weeks, was employed to assay the effect of Nifedipine (a calcium antagonist blocker), S-Adenosylmethionine (a precursor of glutathione); singly and in combination on rat liver cirrhosis. A slight decrease of cirrhosis (N.S.) was observed with the pharmacological therapy employed singly. The combination therapy (Nifedipine+S-Adenosylmethionine) significantly inhibited liver cirrhosis (p < 0.01).
Barrio
E
E
Department of Medicine, Faculty of Medicine, University of Santiago de Compostela, Galicia, Spain.
Cutrín
C
C
Meniño
M J
MJ
Pérez-Becerra
E
E
D000818:Animals; D004359:Drug Therapy, Combination; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy*; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012436:S-Adenosylmethionine / Q000008:administration & dosage / Q000627:therapeutic use*
D012436:S-Adenosylmethionine; D009543:Nifedipine