title: Control of brain volume during hyperosmolar and hypoosmolar conditions.
abstract: The brain is particularly vulnerable to disturbances of body fluid osmolality. Studies in animals indicate that brain adaptation to osmotic stresses is a very complex process involving transient changes in water content and sustained changes in electrolyte and organic osmolyte contents. Appreciation of the nature of the adaptation process enables a better understanding of the marked variations in neurological sequelae that characterize hyper- and hypoosmolar states and provides a basis for more rational therapy.
authors: Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors: S R
authors: SR
authors: Gullans
authors: J G
authors: JG
authors: Verbalis
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000517:prevention & control*; D006801:Humans; D006955:Hypernatremia / Q000150:complications / Q000378:metabolism; D007010:Hyponatremia / Q000150:complications / Q000378:metabolism; D009994:Osmolar Concentration; D014883:Water-Electrolyte Imbalance / Q000150:complications* / Q000378:metabolism*