Paracetamol poisoning and the kidney.
Nephrotoxicity is less common than hepatotoxicity in paracetamol overdose but renal tubular damage and acute renal failure occur even in the absence of hepatotoxicity. It is possible that antidotal therapy with agents such as N-acetylcysteine may not prevent renal toxicity and, indeed, on the basis of animal work, may actually potentiate tubular damage. Careful clinical attention should be paid to renal function in patients poisoned with paracetamol.
Jones
A F
AF
West Midlands Poisons Unit, Dudley Road Hospital, Birmingham, U.K.
Vale
J A
JA
D000082:Acetaminophen / Q000378:metabolism / Q000506:poisoning*; D000111:Acetylcysteine / Q000009:adverse effects; D058186:Acute Kidney Injury / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury; D062787:Drug Overdose; D006801:Humans; D007668:Kidney
D000082:Acetaminophen; D000111:Acetylcysteine