C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.
Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.
Han
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Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347.
Golden
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Han
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Sternberg
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000166:cytology / Q000201:enzymology / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins; D002454:Cell Differentiation / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA; D005260:Female; D015801:Helminth Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019908:Proto-Oncogene Proteins c-raf; D017386:Sequence Homology, Amino Acid; D014844:Vulva / Q000166:cytology*; D018631:ras Proteins
D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; C066646:let-60 protein, C elegans; D004247:DNA; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf; D018631:ras Proteins