Gastroprotective effect of zinc acexamate against damage induced by nonsteroidal antiinflammatory drugs. A morphological study.
The gastroprotective effect of zinc acexamate against gastric damage induced by different nonsteroidal antiinflammatory drugs (indomethacin, diclofenac, and piroxicam) was morphologically assessed in the rat glandular stomach by light and scanning electron microscopy. In addition, the capability of these antiinflammatory drugs to inhibit gastric prostaglandin E2 production was compared with their ability to induce gastric lesions. Microscopically, disappearance of mucus glycoprotein and exfoliation of the mucosal surface were the most common findings. Surface ultrastructural lesions varied from minimal lesions of the surface epithelial cells to deep erosions of the gastric mucosa with release of associated cellular elements and sloughing of the denuded lamina propria. Diclofenac elicited the most powerful inhibitory activity on mucosal prostaglandin E2 (98% inhibition vs control), closely followed by piroxicam (97.8%) and indomethacin (91.05%). Pretreatment of animals with zinc acexamate significantly increased the presence of mucus glycoprotein, maintained the continuity of the surface epithelial cells, and decreased the depth of the mucosal erosions. The degree of protection exerted by zinc acexamate varied with the antiinflammatory, but was always evident.
Bulbena
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O
Departamento de Farmacología, Laboratorios Viñas, S.A., Barcelona, Spain.
Escolar
G
G
Navarro
C
C
Bravo
L
L
Pfeiffer
C J
CJ
D000614:Aminocaproates; D015119:Aminocaproic Acid / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004008:Diclofenac / Q000633:toxicity; D015232:Dinoprostone / Q000032:analysis / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007213:Indomethacin / Q000633:toxicity; D008855:Microscopy, Electron, Scanning; D009336:Necrosis; D010894:Piroxicam / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties
D000614:Aminocaproates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010894:Piroxicam; D004008:Diclofenac; C018802:6-acetylaminocaproic acid; D015232:Dinoprostone; D015119:Aminocaproic Acid; D007213:Indomethacin