Regulation of hepatic and non-hepatic apolipoprotein A-I and E gene expression during liver regeneration.
In this study, we have determined what tissues other than liver express apolipoprotein (apo) A-I and apo E genes during liver regeneration at the level of the specific mRNAs, and have compared these findings with the serum values of high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL). Our results show that liver and intestine express most of the apo A-I mRNA during liver regeneration. Although apo E mRNA is expressed principally by the liver, its expression is reduced in liver during regeneration but is increased markedly in non-hepatic tissues, such as in intestine, kidney, lung and brain. These results suggest that humoral or circulating factors released during liver regeneration influence apolipoprotein E gene expression, not only in hepatic but also in non-hepatic tissue.
Panduro
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A
Department of Gastroenterology, Instituto Nacional de la Nutrición Salvador Zubiran, Tlalpan, Mexico City.
Castrillón
L
L
González
L
L
Shafritz
D A
DA
D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005786:Gene Expression Regulation; D007413:Intestinal Mucosa / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000502:physiology*; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration
D016632:Apolipoprotein A-I; D001057:Apolipoproteins E; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D012333:RNA, Messenger