Haemodynamic and hormonal responses to oral enalapril in salt depleted normotensive man.
A combination of dietary sodium restriction (40 mmol day-1) and frusemide pretreatment has been used to activate the renin angiotensin system (RAS) in order to characterise the haemodynamic and hormonal responses to enalapril in young normotensives. Enalapril significantly reduced supine blood pressure with a mean maximum fall of 19 +/- 7.6, compared with 6.5 +/- 6.8 mm Hg with placebo. Similar but greater responses were seen in erect blood pressure. Mean maximal plasma ACE inhibition (78 +/- 5.7%) was associated with a significant increase in PRA from 5.2 +/- 2.1 ngAI ml-1 h-1 to a peak of 29.1 +/- 6 ngAI ml-1 h-1. This simple well tolerated regimen produced consistent RAS activation and gave readily measurable falls in blood pressure following enalapril. This model may be used to undertake detailed assessments of ACE inhibition, renin inhibition and angiotensin receptor blockade.
MacFadyen
R J
RJ
University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow.
Elliott
H L
HL
Meredith
P A
PA
Reid
J L
JL
D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D004311:Double-Blind Method; D004656:Enalapril / Q000097:blood / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D011188:Potassium / Q000652:urine; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012964:Sodium / Q000172:deficiency*
D004656:Enalapril; D005665:Furosemide; D012964:Sodium; D012083:Renin; D011188:Potassium