Hepatic acylcoenzyme A:cholesterol acyltransferase activity is low in hamsters fed apples in addition to a standard diet.
The effect of consumption of apples as a supplement to a standard diet on hepatic acylcoenzyme A: cholesterol acyltransferase (ACAT) activity was investigated in adult golden hamsters (Mesocricetus auratus). The experimental diet was given for 2 months. IN response to the high-fruit intake, the level of cholesteryl esters was reduced in the liver, and hepatic ACAT activity, determined in vitro under various conditions of incubation, was lowered by about 30%. Moreover, plasma cholesterol was redistributed among the lipoproteins, with a decrease in the cholesterol transported in the ApoB-rich lipoproteins.
Sablé-Amplis
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Laboratoire des Régulations des Métabolismes et Nutrition, CNRS, Université Paul Sabatier, Toulouse, France.
Sicart
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D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D006224:Cricetinae; D005638:Fruit; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D002785:Sterol O-Acyltransferase / Q000378:metabolism*
D002784:Cholesterol; D002785:Sterol O-Acyltransferase