Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis.
Mesangial proliferative glomerulonephritis (mesPGN) is histologically characterized by proliferation of mesangial cells (MC), suggesting the involvement of a growth factor for MC in the pathogenesis of mesPGN. We have previously shown that interleukin-6 (IL-6) induces proliferation of cultured rat mesangial cells, and urine samples from patients with IgA nephropathy contain high level of IL-6 activity. We have also demonstrated that transgenic mice carrying a human IL-6 genomic gene showed severe mesangial proliferation and matrix enlargement. Urinary samples of patients with lupus nephritis as well as IgA nephropathy contain significant IL-6 activity. Over a ten month follow-up, a positive correlation between the urinary IL-6 and pathological score was observed. Hence, measurement of urinary IL-6 can be used as a good indicator for monitoring IgA nephropathy and lupus nephritis. Using RT-PCR methods, IL-6 mRNA was detected in the glomeruli of renal biopsy specimens obtained from patients with IgA nephropathy and lupus nephritis.
Horii
Y
Y
First Department of Internal Medicine, Nara Medical University, Japan.
Iwano
M
M
Hirata
E
E
Shiiki
M
M
Fujii
Y
Y
Dohi
K
K
Ishikawa
H
H
D000818:Animals; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000235:genetics / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000502:physiology* / Q000652:urine; D008181:Lupus Nephritis / Q000209:etiology / Q000235:genetics / Q000473:pathology; D051379:Mice; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics
D015850:Interleukin-6; D012333:RNA, Messenger