Arterial intimal flaps: a comparison of primary repair, aspirin, and endovascular excision in an experimental model.
The optimal management for traumatic arterial intimal injuries is unresolved. Three therapeutic options were compared in an experimental model employing a standard intimal flap created in 51 canine superficial femoral arteries. Group 1 (14 arteries) underwent resection with end-to-end repair. Group 2 (19 arteries) received acetylsalicylic acid (ASA) and observation only. Group 3 (21 arteries) underwent endovascular excision of the flap with angioscopic guidance. Control intimal flaps (18 arteries) were created and observed without further intervention. Patency in group 1 (primary repair) and group 2 (ASA) was 100%; the patency in both was significantly (p < 0.05) greater than in the controls, which was 67%. Patency in group 3 (endovascular excision) was 79%. Residual luminal defects were observed in only 8% of the arteries repaired primarily, but in 76% of the aspirin-treated arteries. Residual luminal defects following endovascular excision were present in 53% of the arteries remaining patent. Although resection and primary repair (group 1) provided better results than observation alone (control), addition of ASA (group 2) also sustained patency. However, a high incidence of residual intimal defects occurred, the natural history of which is unknown. While endovascular excision (group 3) may become a feasible alternative, current technology provided inferior patency with frequent residual intimal defects. These results suggest that observation alone supplemented with antiplatelet medication (ASA) may be adequate treatment, but longer follow-up is necessary for confirmation.
Hernández-Maldonado
J J
JJ
Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103-6601.
Padberg
F T
FT
Teehan
E
E
Neville
R
R
DeFouw
D
D
Durán
W N
WN
Hobson
R W
RW
D017546:Angioscopy; D000818:Animals; D001158:Arteries / Q000293:injuries* / Q000601:surgery; D001241:Aspirin / Q000627:therapeutic use*; D004285:Dogs; D004730:Endothelium, Vascular / Q000601:surgery*; D005069:Evaluation Studies as Topic; D005260:Female; D005263:Femoral Artery / Q000293:injuries / Q000601:surgery; D008297:Male; D016896:Treatment Outcome; D017539:Tunica Intima / Q000293:injuries* / Q000601:surgery; D014654:Vascular Patency; D014947:Wounds and Injuries / Q000188:drug therapy / Q000601:surgery
D001241:Aspirin