Thyroid hormone restores atrial stretch-induced secretion of atrial natriuretic peptide in hypophysectomized rats.
Acute blood volume expansion caused a rapid and profound release of atrial natriuretic peptides (ANP) from cardiac atria. The stimulated release of ANP was markedly blunted (more than 50%) in hypophysectomized rats (8 days after surgery). Daily subcutaneous injections of thyroxine (30 micrograms/kg) to hypophysectomized rats for 7 days, completely restored acute volume expansion induced release of ANP. Our data suggest that thyroid hormone is required for ANP secretion in response to acute volume expansion.
Zamir
N
N
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel.
Slover
M
M
Ohman
K P
KP
D000818:Animals; D016275:Atrial Function; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000502:physiology; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D007016:Hypophysectomy; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*
D009320:Atrial Natriuretic Factor; D013974:Thyroxine