Effect of insulin therapy on progression of retinopathy in noninsulin-dependent diabetes mellitus.
In a six-month prospective study involving 60 noninsulin-dependent diabetics, we evaluated the effect of change to conventional insulin therapy on the pre-existing retinopathy. Ten of 15 patients in group 1 (background or preproliferative diabetic retinopathy treated with insulin) compared to one of 15 patients in group 2 (background or preproliferative diabetic retinopathy treated with hypoglycemic agents) had progression of retinopathy. Worsening of retinopathy was related significantly only to the age of the patients (r = .752, P < .001). None of the 15 patients each in groups 3 and 4 (no retinopathy treated with insulin injections [group 3] or oral hypoglycemic agents [group 4]) developed retinopathy.
Roysarkar
T K
TK
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Gupta
A
A
Dash
R J
RJ
Dogra
M R
MR
D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003930:Diabetic Retinopathy / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin