Technique for the continuous infusion of high doses of cocaine by osmotic minipump.
The present article describes a procedure for modifying osmotic minipumps to avoid the local, toxic, necrotic effects of high concentrations of drug at the exit portal during the chronic, continuous infusion of cocaine. The present procedure eliminates the occurrence of necrotic skin lesions otherwise produced by SC administration of cocaine and/or other vasoconstrictive agents. The method of administration will therefore be useful for administration of other chronic drug regimens.
Joyner
C
C
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
King
G
G
Lee
T H
TH
Ellinwood
E H
EH
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D003956:Dialysis; D004343:Drug Implants; D009336:Necrosis; D051381:Rats; D012867:Skin / Q000473:pathology
D004343:Drug Implants; D003042:Cocaine