Delayed neurotoxic effect of sarin in mice after repeated inhalation exposure.
Delayed neurotoxicity of sarin in mice after repeated inhalation exposure has been studied. Female mice exposed to atmospheric sarin (5 mg m-3 for 20 min) daily for 10 days developed muscular weakness of the limbs and slight ataxia on the 14th day after the start of the exposure. These changes were accompanied by significant inhibition of neurotoxic esterase (NTE) activity in the brain, spinal cord and platelets. Histopathology of the spinal cord of exposed animals showed focal axonal degeneration. These changes were comparatively less than in animals treated with the neurotoxic organophosphate, mipafox. Results from this study indicate that sarin may induce delayed neurotoxic effects in mice following repeated inhalation exposure.
Husain
K
K
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.
Vijayaraghavan
R
R
Pant
S C
SC
Raza
S K
SK
Pandey
K S
KS
D000280:Administration, Inhalation; D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000473:pathology; D001792:Blood Platelets / Q000201:enzymology; D001921:Brain / Q000201:enzymology / Q000473:pathology; D002265:Carboxylic Ester Hydrolases / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D007531:Isoflurophate / Q000031:analogs & derivatives / Q000633:toxicity; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D009468:Neuromuscular Diseases / Q000139:chemically induced / Q000473:pathology; D012524:Sarin / Q000008:administration & dosage / Q000633:toxicity*; D013116:Spinal Cord / Q000201:enzymology / Q000473:pathology
D007531:Isoflurophate; C005238:mipafox; D012524:Sarin; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase