Amino acids and peptides. XVII. Synthesis of peptides related to N-terminal portion of fibrin alpha-chain and their inhibitory effect on fibrinogen/thrombin clotting.
Various peptides related to N-terminal portion of fibrin alpha-chain were synthesized by the solution method and the solid-phase method, and their inhibitory effect on fibrinogen/thrombin clotting was examined. Extension of peptide chain from N-terminal tripeptide decreased the inhibitory effect. The most potent effect was shown by N-terminal decapeptide analog, H-Gly-Pro-Arg-Pro-Pro-Glu-Arg-His-Gln-Ser-NH2.
Kawasaki
K
K
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Tsuji
T
T
Hirase
K
K
Miyano
M
M
Inouye
S
S
Iwamoto
M
M
D000595:Amino Acid Sequence; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D005337:Fibrin / Q000737:chemistry*; D005340:Fibrinogen / Q000378:metabolism; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D013917:Thrombin / Q000378:metabolism
D000925:Anticoagulants; D009842:Oligopeptides; D010446:Peptide Fragments; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin