Effects of neurotoxins on brain creatine kinase activity.
The effects of ethylene oxide (EO), acrylamide, N,N'-methylene-bis-acrylamide (bis-acrylamide), and methyl mercury chloride (MMC) on brain creatine kinase (CK) activity were examined in vivo. EO and acrylamide, both of which cause central-peripheral distal axonopathy, inhibited CK activity in the brain and spinal cord. On the other hand, neither bis-acrylamide, a nonneurotoxic analogue, nor MMC which causes neuronopathy affected brain CK activity significantly. The inhibition of CK may play a role in the pathogenesis of distal axonal degeneration in the central and peripheral nervous systems.
Matsuoka
M
M
Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Inoue
N
N
Igisu
H
H
Kohriyama
K
K
D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003402:Creatine Kinase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005027:Ethylene Oxide / Q000633:toxicity*; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology
D000178:Acrylamides; D008767:Methylmercury Compounds; D003402:Creatine Kinase; D005027:Ethylene Oxide