Oligomers of 4-chloroaniline are intermediates formed during its biodegradation by Phanerochaete chrysosporium.
Lignin peroxidase H2 (LP-H2) from Phanerochaete chrysosporium oxidized 4-chloroaniline to form several oligomers. Included among the compounds identified were: 4,4'-dichloroazobenzene, 2-(4-chloroanilino)-5-hydroxybenzoquinone-di-4-chloroanil and 2-amino-5-(4-chloroanilino) benzoquinone-di-4-chloroanil. In contrast to results by others, we showed that oligomers of 4-chloroaniline were also formed by the fungus in vivo. It was also demonstrated that, although these potentially toxic intermediates are made, they are also degraded.
Chang
C W
CW
Interdisciplinary Program in Toxicology, Utah State University, Logan.
Bumpus
J A
JA
D000814:Aniline Compounds / Q000737:chemistry / Q000378:metabolism*; D001487:Basidiomycota / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002851:Chromatography, High Pressure Liquid; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism
D000814:Aniline Compounds; D010544:Peroxidases; C042858:lignin peroxidase; C004658:4-chloroaniline