title: X-ray fluorescence determination of bromine traces in pharmaceutical formulations containing sodium diclofenac.
abstract: The X-ray fluorescence spectroscopy (XRF) on solid samples is applied to the organic bromine impurities assay on pharmaceutical formulations of sodium diclofenac (DCF). A wide range of Br contents (7-1564 ppm) in the tablets is obtained, depending on manufacturer source and batch preparation. As the impurities concern only the sodium diclofenac employed, and the presence of Br might be a toxicity index arising from the synthetic procedure, the assay of each DCF batch is suggested.
authors: Department of Pharmaceutical Sciences, University of Bologna, Italy.
authors: M A
authors: MA
authors: Raggi
authors: F
authors: F
authors: Lucchini
authors: P
authors: P
authors: Da Re
mesh_terms: D001966:Bromine / Q000032:analysis*; D004008:Diclofenac / Q000032:analysis*; D004340:Drug Contamination; D012015:Reference Standards; D013052:Spectrometry, X-Ray Emission
chemical_list: D004008:Diclofenac; D001966:Bromine