title: Association of nonsuppression of cortisol on the DST with primary polydipsia in chronic schizophrenia.
abstract: Thirteen polydipsic and 40 nonpolydipsic chronic schizophrenic patients received the dexamethasone suppression test while stabilized on psychotropic medication regimens. Thirty-eight percent (N = 5) of those with polydipsia but only 5% (N = 2) of those without polydipsia were nonsuppressors of cortisol (i.e., had an abnormal response). It is suggested that hippocampal dysfunction could cause both polydipsia and cortisol dysregulation in these patients.
authors: Department of Psychiatry, University of Chicago, IL 60637.
authors: M B
authors: MB
authors: Goldman
authors: L
authors: L
authors: Blake
authors: R C
authors: RC
authors: Marks
authors: D
authors: D
authors: Hedeker
authors: D J
authors: DJ
authors: Luchins
mesh_terms: D000293:Adolescent; D000328:Adult; D003907:Dexamethasone; D004326:Drinking; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology; D014883:Water-Electrolyte Imbalance / Q000097:blood* / Q000503:physiopathology
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone