Limited but evident protective effects of MK-801 and pentobarbital on neuronal damage following forebrain ischemia in the gerbil under normothermic conditions.
The purpose of this study was to examine the protective effects of an N-methyl-D-aspartate receptor antagonist, MK-801, and pentobarbital against neuronal damage in a global ischemia model under controlled body temperature. Gerbils were subjected to 3 and 5 min of bilateral common carotid artery occlusion. MK-801 (1 and 5 mg/kg, i.p.), administered 30 min before ischemia, significantly attenuated the degeneration of hippocampal CA1 pyramidal cells after 3 min of ischemia in a dose dependent manner, but had no such effects after 5 min of ischemia. Pentobarbital (40 mg/kg, i.p.) also protected against CA1 damage after 3 min of ischemia but not after 5 min of ischemia. Thus, we confirmed the protective effects of these agents under normothermic conditions, although these effects were limited to shorter periods of ischemia.
Murase
K
K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kato
H
H
Kogure
K
K
D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D017536:Carotid Artery, Common / Q000502:physiology; D016923:Cell Death / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology*
D016291:Dizocilpine Maleate; D000255:Adenosine Triphosphate; D010424:Pentobarbital