[Molecular biology in development of fatty liver--regulation of apolipoprotein B synthesis].
Apolipoprotein B (apo B) synthesis in fatty liver was described in this review. Apo B synthesis has not been intensively studied in fatty liver. Recently, we demonstrated that hepatic apo B mRNA level increased in two experimental models of fatty liver. Davidson et al. reported that apo B mRNA editing was enhanced in fatty liver induced by refeeding after fasting. However, further investigation is needed to clarify whether alteration in apo B gene regulation participates in development of fatty liver.
Kawata
S
S
Second Department of Internal Medicine, Osaka University Medical School.
Fukuda
K
K
Inui
Y
Y
Matsuzawa
Y
Y
D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics / Q000378:metabolism*; D015243:Cholesterol, VLDL / Q000096:biosynthesis / Q000378:metabolism; D002796:Choline Deficiency / Q000150:complications; D005234:Fatty Liver / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008099:Liver / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology
D001055:Apolipoproteins B; D015243:Cholesterol, VLDL; D012333:RNA, Messenger