title: Spastic quadriplegia in Western Australia. II: Pedigrees and family patterns of birthweight and gestational age.
abstract: Pedigrees were obtained for all 74 index children and for three controls for each case. Recurrence of similar spastic quadriplegic phenotypes occurred in two families. A karyotype of 46,XY,dup(13)(q14q34), resulting in a partial trisomy 13, was found in another case. Rates of miscarriages and stillbirths plus neonatal deaths were higher among siblings of index cases than in siblings of birth-year controls, but were similar to siblings of birthweight controls. Average birthweights and gestational ages were lower in index cases than in birth-year controls. Children with spastic quadriplegia had significantly lower birthweights and gestational ages than their siblings. However, they also tended to come from families with a pattern of low birthweight and preterm delivery. The differences between families remained after controlling for factors affecting birthweight.
authors: Department of Anatomy and Human Biology, University of Western Australia.
authors: B
authors: B
authors: Petterson
authors: F J
authors: FJ
authors: Stanley
authors: B J
authors: BJ
authors: Garner
mesh_terms: D001315:Australia / Q000453:epidemiology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D005192:Family Health; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D009128:Muscle Spasticity; D010375:Pedigree; D011247:Pregnancy; D011782:Quadriplegia / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D014314:Trisomy / Q000235:genetics