title: Three-year neuropsychological follow-up in a selected group of HIV-infected homosexual/bisexual men.
abstract: OBJECTIVE
  To evaluate changes in cognition in a selected group of asymptomatic homosexual/bisexual men over a 3-year period.
  
  
  METHODS
  Sixty HIV-infected (Centers for Disease Control stage II) subjects and 60 controls (individually matched for age and years in education) were administered neuropsychological tests evaluating attention, language, memory, logic and visuo-motor abilities. None of the patients had a history of alcohol or drug abuse, and all received the baseline cognitive evaluation within 18-24 months of seroconversion.
  
  
  RESULTS
  The HIV-infected subjects differed from controls in only one of the six memory tests (P < 0.01). Follow-up evaluation after 18 and 36 months (available for 51 and 36 subjects, respectively) demonstrated a significant deterioration in visuo-motor ability (P < 0.01) only in subjects who had progressed to AIDS, without signs or symptoms of central nervous system involvement.
  
  
  CONCLUSIONS
  The data suggest that cognitive alterations in asymptomatic stages of HIV infection are in most subjects minor and do not develop. Percentage rates of CD4 lymphocyte decline appear to be significantly related to deterioration in visuo-motor abilities.
authors: Neuro AIDS-Unit, IRCCS C. Mondino, University of Pavia, Italy.
authors: M
authors: M
authors: Mauri
authors: E
authors: E
authors: Sinforiani
authors: S
authors: S
authors: Muratori
authors: R
authors: R
authors: Zerboni
authors: G
authors: G
authors: Bono
mesh_terms: D000328:Adult; D001727:Bisexuality; D003071:Cognition; D015658:HIV Infections / Q000503:physiopathology / Q000523:psychology*; D006716:Homosexuality; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D013997:Time Factors