title: Hypolipidemic activity of 1-acyl- and 1,2-diacyl-3,5-pyrazolidinediones.
abstract: A series of substituted 1-acyl- and 1,2-diacyl-3,5-pyrazolidinediones were found to have hypolipidemic properties lowering both serum cholesterol and triglyceride levels in rodents. For optimal activity of the pyrazolidinediones, both nitrogen atoms of the ring needed to be substituted preferentially with MeCO groups. This compound lowered rat VLDL but did not elevate HDL cholesterol content.
authors: Department of Chemistry, North Carolina Central University, Durham.
authors: R A
authors: RA
authors: Izydore
authors: J A
authors: JA
authors: Bernal-Ramirez
authors: W A
authors: WA
authors: Okwisa
authors: L V
authors: LV
authors: Yarborough
authors: O T
authors: OT
authors: Wong
authors: I H
authors: IH
authors: Hall
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D000960:Hypolipidemic Agents; D008055:Lipids; D011720:Pyrazoles; D014280:Triglycerides; D002784:Cholesterol