title: Bronchodilating effects of the novel potassium channel opener HOE 234 in human airways in vitro.
abstract: Bronchodilating effects of the novel potassium channel opener HOE 234 were examined in human bronchi in vitro and compared with those of BRL 38227. HOE 234 produced concentration-dependent relaxations of spontaneous tone and of tone increased by methacholine (10(-6) M), with mean EC50 values of 11 nM and 47 nM, respectively (n = 5). The relaxation produced by HOE 234 was 7 and 3.5 fold more potent than that by BRL 38227 on spontaneous and induced tone, respectively, and was inhibited by glibenclamide (10(-5) M). These results suggest that HOE 234 is a potent bronchodilator which activates ATP-sensitive potassium channels in human airways.
authors: Department of Thoracic Medicine, National Heart & Lung Institute, London, UK.
authors: M
authors: M
authors: Miura
authors: M G
authors: MG
authors: Belvisi
authors: J K
authors: JK
authors: Ward
authors: S
authors: S
authors: Tadjkarimi
authors: M H
authors: MH
authors: Yacoub
authors: P J
authors: PJ
authors: Barnes
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D001578:Benzopyrans / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002839:Chromans / Q000494:pharmacology*; D019806:Cromakalim; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D015221:Potassium Channels / Q000187:drug effects*; D011758:Pyrroles / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*
chemical_list: D001578:Benzopyrans; D001993:Bronchodilator Agents; D002839:Chromans; D009125:Muscle Relaxants, Central; D015221:Potassium Channels; D011758:Pyrroles; D011759:Pyrrolidines; D019806:Cromakalim; C075012:rilmakalim; D000255:Adenosine Triphosphate