Osteoinductive activity of composites of bone morphogenetic protein and pure titanium.
Titanium sponges were infused with bone morphogenetic protein (BMP-Ti), and the osteoinductivity of the resultant composite was measured. New bone formation occurred three weeks after implantation and was identified by soft x-ray analysis. Quantitative analysis showed no significant difference between BMP-Ti composites and control samples (BMP only). Consequently, pure titanium neither inhibited nor promoted BMP activity. Chondrocytes and new bone formation occurred in direct contact with the surfaces of the titanium. X-ray microanalysis demonstrated new bone formation inside the pores of the titanium sponges. The BMP-Ti composite has interesting properties as an osteoinductive implant and has potential practical clinical applications.
Kawai
T
T
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Mieki
A
A
Ohno
Y
Y
Umemura
M
M
Kataoka
H
H
Kurita
S
S
Koie
M
M
Jinde
T
T
Hasegawa
J
J
Urist
M R
MR
D000818:Animals; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000033:anatomy & histology / Q000378:metabolism*; D004337:Drug Carriers; D006614:Hindlimb; D051379:Mice; D011506:Proteins / Q000378:metabolism*; D014025:Titanium / Q000378:metabolism / Q000494:pharmacology*
D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D011506:Proteins; D014025:Titanium