Effect of transdermally administered scopolamine on the vestibular system in humans.
In order to elucidate the effect of scopolamine on the vestibular system in humans, various experimentally-induced forms of nystagmus, i.e. caloric nystagmus, rotational nystagmus, optokinetic nystagmus, visual-vestibular interaction and optokinetic after nystagmus, were evaluated before and after the administration of two pieces of Scopoderm-TTS or placebo patches retro-auricularly. Scopolamine reduced the responses of both the caloric and optokinetic after nystagmus compared with the placebo. The possible action site of this drug is discussed.
Shojaku
H
H
Department of Otolaryngology, Toyama Medical and Pharmaceutical University, Japan.
Watanabe
Y
Y
Ito
M
M
Mizukoshi
K
K
Yajima
K
K
Sekiguchi
C
C
D000279:Administration, Cutaneous; D000328:Adult; D004584:Electronystagmography / Q000187:drug effects / Q000295:instrumentation; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy* / Q000503:physiopathology; D009760:Nystagmus, Physiologic / Q000187:drug effects* / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000187:drug effects* / Q000502:physiology; D012601:Scopolamine / Q000008:administration & dosage*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D014724:Vestibular Function Tests; D014725:Vestibular Nerve / Q000187:drug effects* / Q000503:physiopathology
D012601:Scopolamine