title: Production and regulation of gelatinase B by human T-cells.
abstract: Here we describe for the first time the production of gelatinase B (MMP 9; 92-kDa type IV collagenase) by human peripheral blood T-lymphocytes. Expression of this enzyme was found to be dependent on the activation status of these T-cells and to be regulated by Interleukin-2.
authors: Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
authors: A M
authors: AM
authors: Montgomery
authors: H
authors: H
authors: Sabzevari
authors: R A
authors: RA
authors: Reisfeld
mesh_terms: D002469:Cell Separation; D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000235:genetics* / Q000378:metabolism; D017077:Culture Media, Conditioned / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation; D020780:Matrix Metalloproteinase 9; D010641:Phenotype; D013601:T-Lymphocytes / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism
chemical_list: D017077:Culture Media, Conditioned; D007376:Interleukin-2; D003094:Collagen; D017364:Collagenases; D020780:Matrix Metalloproteinase 9