title: Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment.
abstract: When methylazoxymethanol acetate is administered to pregnant rats at gestational day 19, the offspring are greatly impaired in the learning of a two-way active avoidance task and these behavioral changes are paralleled by a change in the phosphorylation of the protein B-50/GAP-43 in hippocampus but not in cortex. The expression of the protein is not altered, indicating that the phosphorylation of B-50 is a sensitive marker of alterations in synaptic plasticity associated with impairments of learning abilities in rats.
authors: Institute of Pharmacological Sciences, University of Milan, Italy.
authors: M
authors: M
authors: Di Luca
authors: F
authors: F
authors: Merazzi
authors: P N
authors: PN
authors: De Graan
authors: M
authors: M
authors: Cimino
authors: W
authors: W
authors: Balduini
authors: W H
authors: WH
authors: Gispen
authors: F
authors: F
authors: Cattabeni
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D019922:GAP-43 Protein; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008746:Methylazoxymethanol Acetate / Q000633:toxicity; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000187:drug effects; D010766:Phosphorylation; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019922:GAP-43 Protein; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D008746:Methylazoxymethanol Acetate