Prediction and management of adverse events associated with the use of factor IX complex concentrates.
Among the adverse events that have been associated with the use of F IX CC in inhibitor patients, the likelihood of transmission of blood-borne pathogens is now greatly reduced. However, one must be aware of the possibility of thrombotic complications and acute myocardial infarction when using large, repetitive doses of F IX CC. A greater awareness of such potentially life-threatening complications, and avoidance of frequent, repetitive large doses, should decrease the risk. F IX CC are not always effective in achieving or maintaining hemostasis in hemophiliacs with inhibitors. Thus, in subjects who are responding suboptimally, in those in need of surgical intervention, or in those who have large intramuscular hemorrhages and/or will require a prolonged period of treatment, alternative therapeutic approaches should be considered.
Lusher
J M
JM
Wayne State University School of Medicine, Detroit, MI.
D001778:Blood Coagulation Disorders / Q000188:drug therapy; D005164:Factor IX / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000139:chemically induced; D013927:Thrombosis / Q000139:chemically induced; D014777:Virus Diseases / Q000635:transmission
D005164:Factor IX