title: [Pityriasis-lichenoides-et-varioliformis-acuta-like drug exanthema caused by astemizole].
abstract: We report on a 40-year-old male patient who developed an unusual generalized drug eruption taking the form of a histologically confirmed pityriasis lichenoides et varioliformis acuta (PLEVA) after oral intake of the H1-antagonist astemizole. On two occasions, independently repeated medication with astemizole exacerbated the typical rash again. Oral exposure and the specific lymphocyte transformation test confirmed the suspected causal connection between astemizole and PLEVA.
authors: Universitäts Hautklinik Erlangen.
authors: N
authors: N
authors: Stosiek
authors: K P
authors: KP
authors: Peters
authors: P
authors: P
authors: von den Driesch
mesh_terms: D000284:Administration, Oral; D000328:Adult; D016589:Astemizole / Q000008:administration & dosage / Q000009:adverse effects*; D001706:Biopsy; D003875:Drug Eruptions / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D017514:Pityriasis Lichenoides / Q000139:chemically induced* / Q000473:pathology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D012867:Skin / Q000473:pathology
chemical_list: D016589:Astemizole
vernacular_title: Pityriasis-lichenoides-et-varioliformis-acutaähnliches Arzneiexanthem durch Astemizol.