[The use of preparations of protozoan origin as agents for the prevention and early therapy of combined radiation-thermal injuries].
Radioprotective and therapeutic effects of astazian and astazilide, the drugs of protozoan origin, were studied in comparison with known modifiers of biological reactions (bacterial polysaccharides, synthetic polypeptides) in combined radiation-thermal injuries (CRTI). The efficiency of drugs under examination was found to be time- and dose-dependent. Application of the drugs of protozoan nature 24 hours prior to or 1 hour following CRTI provided 30 to 50% survival of experimental animals for 30 days as compared to 4.5% in the group of untreated mice. Administration of the drugs 3-7 days following CRTI exerted no therapeutic effect.
Khlopovskaia
E I
EI
Budagov
R S
RS
Sukhareva
N N
NN
Uriniuk
V M
VM
Kotova
I B
IB
D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D056890:Eukaryota; D005227:Fatty Acids / Q000627:therapeutic use*; D005936:Glucans / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000627:therapeutic use; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011134:Polysaccharides / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use; D011749:Pyrogens / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013997:Time Factors
D005227:Fatty Acids; D005936:Glucans; D008070:Lipopolysaccharides; D011134:Polysaccharides; D011749:Pyrogens; D011837:Radiation-Protective Agents; C009136:pyrogenal; C003045:paramylon; D011354:Prodigiozan; C052057:astasilid
Ispol'zovanie preparatov protozoĭnogo proiskhozhdeniia v kachestve sredstv profilaktiki i ranneĭ terapii kombinirovannykh radiatsionno-termicheskikh porazheniĭ.