title: Synthesis and antifungal activities of pradimicin A derivatives modification of the alanine moiety.
abstract: Chemical modifications of the carboxyl group in the alanine moiety of pradimicin A were performed and in vitro and in vivo antifungal activities of the derivatives were examined in comparison with those of pradimicin A. The amide derivatives showed activities comparable to pradimicin A, indicating that the free carboxyl group can be modified without impairing the antifungal activity.
authors: Bristol-Myers Squibb Research Institute, Tokyo, Japan.
authors: M
authors: M
authors: Nishio
authors: H
authors: H
authors: Ohkuma
authors: M
authors: M
authors: Kakushima
authors: S
authors: S
authors: Ohta
authors: S
authors: S
authors: Iimura
authors: M
authors: M
authors: Hirano
authors: M
authors: M
authors: Konishi
authors: T
authors: T
authors: Oki
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives; D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002177:Candidiasis / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D000095643:Pradimicins and Benanomicins
chemical_list: D000409:Alanine; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C058036:pradimicin A; D000095643:Pradimicins and Benanomicins