Response of "benign" metastasizing leiomyoma to progestin withdrawal. Case report.
We report a rare case of a benign metastasizing leiomyoma in which progestin therapy permitted or promoted pulmonary metastases, but progestin withdrawal induced a marked tumor regression. The significance of these observations is discussed relative to the estrogen and progesterone receptor positivity of this patient's tumor.
Cohen
J D
JD
Division of Hematology/Oncology Denver Veterans Administration Medical Center.
Robins
H I
HI
D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy* / Q000556:secondary; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000556:secondary; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects / Q000627:therapeutic use; D008535:Megestrol / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D019290:Megestrol Acetate; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000556:secondary; D045167:Progesterone Congeners / Q000009:adverse effects* / Q000627:therapeutic use; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000601:surgery
D045167:Progesterone Congeners; D017258:Medroxyprogesterone Acetate; D008535:Megestrol; D019290:Megestrol Acetate