Allopurinol and oxypurinol in human breast milk.
To pregnant or breast feeding women drugs should be given with caution. We report the case of a 5-week-old breast-fed infant whose mother was taking 300mg allopurinol/day for 4 weeks. Allopurinol and oxypurinol were detected by HPLC in maternal plasma and breast milk with a method first described here. In infant's plasma taken 2 h after breast feeding oxypurinol was found; allopurinol was below the limit of detection. The milk/plasma ratio in the mother 2 h (4 h) after drug ingestion was 0.9 (1.4) for allopurinol and 3.9 (2.4) for oxypurinol. The average daily dose for the baby of allopurinol was 0.14-0.20 mg/kg and that of oxypurinol 7.2-8.0 mg/kg by ingestion of breast milk after oral intake of allopurinol by the mother.
Kamilli
I
I
Purinlabor der Medizinischer Poliklinik, Universität München.
Gresser
U
U
D000328:Adult; D000493:Allopurinol / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000737:chemistry*; D010117:Oxypurinol / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011644:Puerperal Disorders / Q000097:blood / Q000188:drug therapy; D011704:Pyelonephritis / Q000097:blood / Q000188:drug therapy; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000493:Allopurinol; D010117:Oxypurinol