title: A comparison of newborn versus old skin fibroblasts, their potential for tissue repair.
abstract: An assessment was made of the ability of human skin fibroblasts from newborn and old subjects to produce intracellular urokinase inhibitor and urokinase-plasminogen activator when exposed to phorbol myristate acetate. Urokinase inhibitor produced by human skin fibroblasts may be essential for cell growth regulation. The expression of urokinase inhibitor and/or urokinase-plasminogen activator may possibly be age-related. The principal observation that newborn skin fibroblasts show a low level and poorly sustained production of intracellular inhibitors of urokinase could help to explain the flexibility of the wound healing process in the foetus.
authors: Department of Dermatology, Slade Hospital, Oxford, UK.
authors: Y
authors: Y
authors: Horiuchi
authors: T J
authors: TJ
authors: Ryan
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
chemical_list: D001798:Blood Proteins; C031220:urokinase inhibitor; D014568:Urokinase-Type Plasminogen Activator; D013755:Tetradecanoylphorbol Acetate