Acute myeloblastic leukemia (ANLL-M2) with t(8;21)(q22;q22) variant expressing lymphoid but not myeloid surface antigens with a high number of G-CSF receptors.
Leukemic cells from an 8-year-old girl with ANLL-M2 expressed precursor B-cell antigen CD19, but none of the myeloid antigens CD11b, CD13, CD14 and CD33. After culture, the cells expressed CD11b and CD13. The cells carried a high number of granulocyte colony-stimulating factor (G-CSF) receptors. In chromosome analysis, metaphase cells were obtained only in the case of culture with G-CSF. The karyotype was a variant of t(8;21)(q22;q22). Southern blot analysis revealed rearrangement of the AMLI gene located on chromosome 21. These observations may suggest that even without myeloid surface antigens and with precursor B-cell antigen, ANLL-M2 with t(8;21)(q22;q22) has apparent myeloid characteristics.
Tsuchiya
H
H
Department of Pediatrics, Kumamoto University School of Medicine, Japan.
ElSonbaty
S S
SS
Nagano
K
K
Watanabe
M
M
Migita
M
M
Mitsubuchi
H
H
Kaneko
Y
Y
Matsuda
I
I
D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology; D002648:Child; D002891:Chromosomes, Human, Pair 21 / Q000502:physiology*; D002898:Chromosomes, Human, Pair 8 / Q000502:physiology*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000032:analysis*; D014178:Translocation, Genetic / Q000235:genetics*
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D016188:Receptors, Granulocyte Colony-Stimulating Factor