Treatment of therapy-related acute myelogenous leukemia and myelodysplastic syndromes.
The number of cases of therapy-related acute myelogenous leukemia and myelodysplastic syndromes has risen with the advances of successful combination chemotherapy. Unfortunately, the therapy-related diseases are difficult to treat. Aggressive induction chemotherapy can induce a complete remission, but the remission duration is short. Differentiating agents, hormonal agents, and growth factors have all been disappointing. Allogeneic bone marrow transplantation remains the only curative approach.
Ballen
K K
KK
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Antin
J H
JH
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced / Q000628:therapy*; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000628:therapy*