Josamycin concentrations in radicular cysts following a single oral administration.
1. Josamycin concentrations in cyst wall (wall) and cyst fluid (fluid) of radicular cyst and serum following a single oral administration of josamycin (600 mg) were assayed by a paper disk method. 2. The mean peak josamycin concentrations in wall, fluid and serum occurred at 1.5, 2 and 1.5 hr, respectively, and were 1.33 micrograms/g, 0.53 and 0.74 micrograms/ml, respectively. 3. The mean concentration ratios of wall/serum, fluid/serum and fluid/wall at the peak times (1.5, 2 and 2 hr) were 1.80, 0.64 and 0.42, respectively. 4. Josamycin concentrations in wall and fluid at the peak time exceeded MIC for 80% for clinically isolated strains of alpha-hemolytic Streptococci.
Akimoto
Y
Y
Department of Oral Surgery, Nihon University School of Dentistry, Chiba, Japan.
Mochizuki
Y
Y
Uda
A
A
Omata
H
H
Saito
S
S
Kaneko
K
K
Fujii
A
A
Yamamoto
H
H
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D007568:Jaw / Q000378:metabolism*; D015570:Josamycin / Q000493:pharmacokinetics*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011842:Radicular Cyst / Q000378:metabolism* / Q000382:microbiology; D013290:Streptococcal Infections / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects
D015570:Josamycin