Bi- and multivariate analyses of diallel crosses: a tool for the genetic dissection of neurobehavioral phenotypes.
The genetic-correlational approach provides a very powerful tool for the analysis of causal relationships between phenotypes. It appears to be particularly appropriate for investigating the functional organization of behavior and/or causal relationships between brain and behavior. A method for the bivariate analysis of diallel crosses that permits the estimation of correlations due to environmental effects, additive-genetic effects, and/or dominance deviations is described, together with a worked-out example stemming from a five times replicated 4 x 4 diallel cross between inbred mouse strains. The phenotypes chosen to illustrate the analysis were locomotor activity and rearing frequency in an open field. Large, positive additive-genetic and dominance correlations between these two phenotypes were obtained. This finding was replicated in another, independently executed, diallel cross.
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URA 1294 CNRS, Université René Descartes, Paris, France.
D000483:Alleles; D000818:Animals; D001143:Arousal / Q000235:genetics*; D003433:Crosses, Genetic; D005106:Exploratory Behavior; D051379:Mice; D008815:Mice, Inbred Strains; D008957:Models, Genetic; D009043:Motor Activity / Q000235:genetics; D010641:Phenotype; D012931:Social Environment