Cisplatin and carboplatin induced changes in the neurohypophysis and parathyroid, and their role in nephrotoxicity.
Cytochemical and ultrastructural studies in Wistar rats [Crl: (WI)BR] show that cisplatin treatment (5-9 mg/kg) induces a release of neurosecretory granules from the neurohypophysis with a corresponding decrease in the urine output in a time and dose dependent fashion. Cisplatin induces low blood calcium and phosphate levels with a corresponding increase in the dark cells of the parathyroid gland. Injections of calcium before and during the treatment of cisplatin are effective in combating hypocalcemia, nephrotoxicity and gastrointestinal toxicity due to cisplatin. Carboplatin, a less nephrotoxic agent, does not demonstrate any of these changes.
Aggarwal
S K
SK
Department of Zoology, Michigan State University, East Lansing 48824-1115.
Fadool
J M
JM
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D016190:Carboplatin / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D004231:Diuresis / Q000187:drug effects; D006651:Histocytochemistry; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D010279:Parathyroid Diseases / Q000139:chemically induced / Q000473:pathology; D010280:Parathyroid Glands / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010900:Pituitary Diseases / Q000139:chemically induced / Q000473:pathology; D010904:Pituitary Gland, Posterior / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D016190:Carboplatin; D000469:Alkaline Phosphatase; D002945:Cisplatin; D002118:Calcium