Environmental regulation of virulence factors in Bordetella species.
Many bacteria respond in a coordinate manner to environmental changes. External stimuli, sensed by receptors, are transduced to regulatory proteins which participate in well defined pathways of gene expression by varying their structure and mode of action. The network of environmental signal transduction is responsible for a fine and continuous communication between the host and the pathogenic bacteria. As a result, the gene expression machinery of the pathogen is modified continuously, in order to establish the optimal conditions for bacterial survival and multiplication.
Scarlato
V
V
Immunobiological Research Institute Siena, Italy.
Aricó
B
B
Domenighini
M
M
Rappuoli
R
R
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001884:Bordetella / Q000235:genetics / Q000472:pathogenicity*; D004777:Environment; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; C065601:BvgA protein, Bacteria; D014157:Transcription Factors; C080662:bvgS protein, Bordetella pertussis