Effect of low intravaginal doses of prostaglandin E2 on the closure time of the ductus arteriosus in term newborn infants.
Seventeen term newborn infants (control subjects) and 17 whose mothers had been given intravaginal doses of prostaglandin E2 (PGE2) were examined serially by color Doppler echocardiography to determine whether maternal PGE2 prolonged ductal patency. No clinically relevant differences in closure times were found. Low-dose intravaginal PGE2 therapy was not associated with prolonged ductal patency in term infants.
Danford
D A
DA
Department of Pediatrics, University of Nebraska College of Medicine, Omaha.
Rayburn
W F
WF
Miller
A M
AM
Felix
G L
GL
Bussey
M E
ME
D000282:Administration, Intravaginal; D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology; D004373:Ductus Arteriosus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010120:Oxytocics; D011247:Pregnancy; D013997:Time Factors
D010120:Oxytocics; D015232:Dinoprostone