Different immunomodulator regulated patterns of effector-target cell interactions: a novel application of microcalorimetry.
Microcalorimetric studies of target/effector cell interactions are reported. Significant changes in the observed thermal profiles are seen upon pre-incubation of the effector cells with chemical immunomodulators. The results of these latter studies indicate that the microcalorimetric technique can reveal differences in the modes of action of different groups of immunomodulators. It is proposed that the technique can be used to screen drug activities and, following further analytical work, to contribute to an understanding of modes of action.
Beezer
A E
AE
Chemical Laboratory, University of Kent, Canterbury, Great Britain.
Navratil
J
J
Fiserova
A
A
Pospisil
M
M
D002151:Calorimetry / Q000379:methods*; D002450:Cell Communication / Q000187:drug effects*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute; D008237:Lysergic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D011043:Pokeweed Mitogens; C074961:10-methoxy-9,10-dihydrolysergol; D008237:Lysergic Acid