[Synthesis and biological properties of new analogs of delta-sleep peptide. I. Antiepileptic effect].
To study structure-functional relationship in the series of DSIP, eleven DSIP analogues varying in positions 1, 2 and 6 were synthesized by the solid-phase method using both Boc- and Fmoc-approaches. The antiepileptic action of these analogues was compared with that of DSIP. The seizure activity was induced by the corazol or picrotoxin i. p. injection. Some analogues proved more efficient as antiepileptic agents than DSIP after their central (50 micrograms/kg in rats) and peripheral (1.0 mg/kg in mice) administration.
Prudchenko
I A
IA
Stashevskaia
L V
LV
Mikhaleva
I I
II
Ivanov
V T
VT
Shandra
A A
AA
Godlevskiĭ
L S
LS
Mazarati
A M
AM
D000595:Amino Acid Sequence; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D003701:Delta Sleep-Inducing Peptide / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D003701:Delta Sleep-Inducing Peptide
Sintez i biologicheskie svoĭstva riada novykh analogov peptida del'ta-sna. I. Antiépilepticheskoe deĭstvie.