title: Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.
authors: Department of Medicinal Chemistry, Molecular Biology, and Virus and Cell Biology, Merck Research Laboratories, West Point, Pennsylvania 19486.
authors: A K
authors: AK
authors: Ghosh
authors: W J
authors: WJ
authors: Thompson
authors: H Y
authors: HY
authors: Lee
authors: S P
authors: SP
authors: McKee
authors: P M
authors: PM
authors: Munson
authors: T T
authors: TT
authors: Duong
authors: P L
authors: PL
authors: Darke
authors: J A
authors: JA
authors: Zugay
authors: E A
authors: EA
authors: Emini
authors: W A
authors: WA
authors: Schleif
mesh_terms: D001665:Binding Sites; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D017320:HIV Protease Inhibitors; D006571:Heterocyclic Compounds; D008024:Ligands; D013450:Sulfones