Diclofenac and ketoprofen for pain treatment after elective caesarean section.
We have studied the effect of a constant infusion of diclofenac 150 mg/24 h, ketoprofen 200 mg/24 h or placebo on postoperative pain after elective Caesarean section performed under spinal or extradural block in 90 patients in a prospective, randomized and double-blind study. During the first 24 h after operation, patients in the treatment groups were more comfortable than the placebo group (P < 0.005); the diclofenac group needed a mean of oxycodone 21.6 mg/24 h and the ketoprofen group 21.2 mg/24 h, compared with 38.3 mg/24 in the placebo group (P < 0.001); the mean time to the first injection of oxycodone was 270.5 min in the diclofenac group, 270.2 min in the ketoprofen group and 161.2 min in the placebo group (P < 0.001). During the first 24 h after operation, the temperature increased in the control group by 0.7 degrees C compared with 0.1 degrees C in the diclofenac group and 0.3 degrees C in the ketoprofen group. One patient in the diclofenac group was eliminated from the study because of uterine relaxation during the first 30 min after start of the drug infusion; this improved after cessation of diclofenac and infusion of sulprostone. There were no other serious side effects.
Rorarius
M G
MG
Department of Anaesthesiology, University Hospital, Tampere, Finland.
Suominen
P
P
Baer
G A
GA
Romppanen
O
O
Tuimala
R
R
D000293:Adolescent; D000328:Adult; D001831:Body Temperature; D002585:Cesarean Section; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000627:therapeutic use*; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies; D014590:Uterine Contraction / Q000187:drug effects; D014592:Uterine Hemorrhage / Q000150:complications
D004008:Diclofenac; D007660:Ketoprofen