Mite asthma in childhood: a study of the relationship between exposure to house dust mites and disease activity.
BACKGROUND
Children with asthma are commonly sensitized to the house dust mite.


METHODS
We took monthly measurements from July to December of the amount of mites in the mattresses of asthmatic children and correlated them with symptom score, pulmonary function, and airway hyperreactivity to methacholine.


RESULTS
In spite of the high number of Dermatophagoides pteronyssinus throughout this period, symptom and treatment scores, as well as PC20 to methacholine, worsened during the months of September and October.


CONCLUSIONS
It is concluded that when asthmatic children allergic to mites are exposed to high levels of mite allergen, the number of mites in the mattress dust no longer correlate with increased symptoms, and that other factors are more likely to be associated with exacerbation.
Kivity
S
S
Allergy Unit, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Israel.
Solomon
A
A
Soferman
R
R
Schwarz
Y
Y
Mumcuoglu
K Y
KY
Topilsky
M
M
D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D004391:Dust / Q000009:adverse effects*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D008925:Mites / Q000276:immunology*
D004391:Dust; D016210:Methacholine Chloride