Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
Receptors for the major excitatory neurotransmitter glutamate may play key roles in neurodegeneration. The mouse Glur-5 gene maps to chromosome 16 between App and Sod-1. The homologous human GLUR5 gene maps to the corresponding region of human chromosome 21, which contains the locus for familial amyotrophic lateral sclerosis. This location, and other features, render GLUR5 a possible candidate gene for familial amyotrophic lateral sclerosis. In addition, dosage imbalance of GLUR5 may have a role in the trisomy 21 (Down syndrome). Further characterization of the murine glutamate receptor family includes mapping of Glur-1 to the same region as neurological mutants spasmodic, shaker-2, tipsy, and vibrator on chromosome 11; Glur-2 near spastic on chromosome 3; Glur-6 near waltzer and Jackson circler on chromosome 10; and Glur-7 near clasper on chromosome 4.
Gregor
P
P
Molecular Neurobiology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
Reeves
R H
RH
Jabs
E W
EW
Yang
X
X
Dackowski
W
W
Rochelle
J M
JM
Brown
R H
RH
Haines
J L
JL
O'Hara
B F
BF
Uhl
G R
GR
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D003433:Crosses, Genetic; D015342:DNA Probes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D008969:Molecular Sequence Data; D009115:Muridae; D009422:Nervous System Diseases / Q000235:genetics*; D009838:Oligodeoxyribonucleotides; D017470:Receptors, Glutamate / Q000235:genetics*; D011995:Recombination, Genetic; D015183:Restriction Mapping
D015342:DNA Probes; D009838:Oligodeoxyribonucleotides; D017470:Receptors, Glutamate