Severe hepatic failure occurring with T61 ingestion in an attempted suicide. Early recovery with the use of intravenous infusion of reduced glutathione.
A case of acute hepatic failure following ingestion of the veterinary euthanasia drug T61 is described. Presenting symptoms were drowsiness, disorientation, muscle hypertonia, and upper limb myoclonus, which faded within a few hours. Two days later, acute liver failure occurred, manifested as encephalopathy, jaundice, and a severe coagulopathy. The hepatic damage was thought to be due to the solvent dimethylformamide, which is the only known hepatotoxin included in the preparation utilized in the suicide attempt. High-dose (1.2 g/day) intravenous reduced glutathione was administered, with a rapid improvement of liver function. The patient was discharged after 17 days. Normalization of all liver function tests was achieved within two months. The favorable outcome in this case stands in contrast to the report of a previous case of lethal T61-induced hepatic failure. Although a different amount of dimethylformamide was ingested in each case (0.45 vs 0.60 ml/kg body wt) and individual differences in susceptibility to the effects of the hepatotoxic agent may have played a major role in these two cases, it is not unlikely that the infusion of high doses of glutathione to our patient contributed to her survival and hepatic recovery.
Trevisani
F
F
Patologia Speciale Medica e Metodologia Clinica I, University of Bologna, Italy.
Tamé
M R
MR
Bernardi
M
M
Tovoli
C
C
Gasbarrini
A
A
Panarelli
M
M
Gasbarrini
G
G
D000328:Adult; D000577:Amides / Q000506:poisoning*; D000777:Anesthetics / Q000506:poisoning*; D004338:Drug Combinations; D005260:Female; D005978:Glutathione / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D009466:Neuromuscular Blocking Agents / Q000506:poisoning*; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D000644:Quaternary Ammonium Compounds / Q000506:poisoning*; D013406:Suicide, Attempted; D013748:Tetracaine / Q000506:poisoning*; D013997:Time Factors
D000577:Amides; D000777:Anesthetics; D004338:Drug Combinations; D009466:Neuromuscular Blocking Agents; D000644:Quaternary Ammonium Compounds; D013748:Tetracaine; C059324:embutramide; C015591:T 61; C059325:mebezonium; D005978:Glutathione