Low-dose-rate irradiation of rat embryo cells containing the Ha-ras oncogene.
Rat embryo cells and derived transfectants containing the Ha-ras oncogenes were irradiated with 60Co gamma rays at dose rates of 0.72, 0.066, 0.035, and 0.018 Gy/min. The measured dose response of cell survival shows that the oncogene-containing cells exhibit higher survival levels at all doses than the parental cells at every dose rate. The response of the cells containing the ras oncogene also became dose-rate independent at a higher dose rate, perhaps indicative of a greater repair capability relative to that of the primary cells.
Ong
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A
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021.
Li
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WX
Ling
C C
CC
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian / Q000166:cytology / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D011905:Genes, ras; D011247:Pregnancy; D051381:Rats; D011916:Rats, Inbred F344; D014162:Transfection
D003037:Cobalt Radioisotopes