title: [Ionization energy and glycoside bond rupture energy of nucleosides, suppressing the reproduction of the human immunodeficiency virus (HIV)].
abstract: By photoionization mass spectrometry the energy characteristics were investigated for a series of nucleosides whose triphosphates possess anti-HIV activity. The electron-donor ability (a value reciprocal to ionization energy) does not correlate with the biological activity of corresponding nucleotides. The energy of glycoside bond rupture depended on modification in deoxyribose.
authors: V M
authors: VM
authors: Orlov
authors: V N
authors: VN
authors: Pustobaev
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry*; D006678:HIV; D013058:Mass Spectrometry; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D006027:Glycosides; D009705:Nucleosides
vernacular_title: Energii ionizatsii i énergii razriva glikozidnoĭ sviazi nukleozidov, podavliaiushchikh reproduktsiiu virusa immunodefitsita cheloveka (VICh).