[Improvement of coronary reserve following regression of hypertrophy resulting from blood pressure lowering therapy with a beta-receptor blocker].
The coronary microcirculation was investigated by the argon gas method in ten patients (eight men, two women; mean age 56 [44-63] years) before and after an average of 12.9 (9-18) months of treatment with the cardioselective beta-receptor blocker bisoprolol. Left ventricular muscle mass was measured echocardiographically, before and after the treatment. All these patients were known to have hypertension, with exercise-related angina and ischaemic signs in the resting ECG, but normal coronary angiograms. After the treatment period both maximal coronary perfusion and coronary reserve had increased by 22%. At the same time, left ventricular muscle mass had decreased from 161 +/- 18 to 146 +/- 21 g/m2. These results demonstrate that blood pressure reducing treatment can bring about not only a regression of left ventricular hypertrophy, but also an improvement in coronary reserve.
Motz
W
W
Abteilung für Kardiologie, Pneumologie und Angiologie, Universität Düsseldorf.
Vogt
M
M
Scheler
S
S
Schwartzkopff
B
B
Strauer
B E
BE
D000328:Adult; D001128:Argon / Q000032:analysis; D017298:Bisoprolol / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000503:physiopathology*; D002849:Chromatography, Gas; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged
D001128:Argon; D017298:Bisoprolol
Verbesserung der Koronarreserve nach Hypertrophieregression durch blutdrucksenkende Therapie mit einem beta-Rezeptorenblocker.