Human B cell lymphomas: in vitro and in vivo studies on growth factors and cell growth.
The B cell non-Hodgkin's lymphomas (NHL-B) are a common, but heterogeneous group of human lymphoid neoplasms, consisting of monoclonal populations of neoplastic B lymphocytes demonstrating non-random chromosomal abnormalities, often associated with proto-oncogene translocations. Clinically and pathologically, these lymphomas are classified as low, intermediate, or high grade, according to the clinical aggressiveness of the NHL-B subtype. The clinical behavior can also be correlated with biological function regarding proliferative capabilities of the tumor cells. Our studies have shown that the low grade B cell lymphomas have low constitutive proliferative capacity in vitro and do not respond to cytokine growth factors (CGF), while the high grade NHL-B respond to the B cell growth factor (BCGF) family of CGFs. The high grade NHL-B also secrete BCGFs both in vitro and in vivo, as autocrine growth factors that may provide a target for new therapeutic approaches to therapy.
Ford
R J
RJ
Department of Molecular Pathology, MD Anderson Cancer Center, Houston, Texas 77030.
Tamayo
A
A
Li
D J
DJ
Cabanillas
F
F
D000818:Animals; D002455:Cell Division; D006801:Humans; D015847:Interleukin-4 / Q000502:physiology*; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000628:therapy; D000090063:Proto-Oncogene Mas; D014407:Tumor Cells, Cultured
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D015847:Interleukin-4