[Synthesis of platelet activation factor analogs].
Novel structural analogues of the platelet activating factor (PAF), rac-1-octadecyl-2-allyl-glycerol-3-phosphocholine and rac-1-octadecyl-2-allyl-1-thioglycerol-3-phosphocholine , have been synthesized. The phospholipids obtained showed neither PAF-agonistic nor PAF-antagonistic activity at the concentration of 10(-5) to 10(-7) M.
Sablina
M A
MA
Ushakova
I P
IP
Dement'eva
E V
EV
Dergousov
A A
AA
Serebrennikova
G A
GA
D006801:Humans; D010767:Phosphorylcholine / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
D010972:Platelet Activating Factor; D010767:Phosphorylcholine
Sintez analogov faktora aktivatsii trombotsitov.