title: Absence of a capnogram after positive end-expiratory pressure.
abstract: OBJECTIVE
  The objective of this study was to evaluate the effect of positive end-expiratory pressure (PEEP) on capnography.
  
  
  METHODS
  The study design was experimental and open, and it was performed in the Anesthesiology Experimental Research Laboratory.
  
  
  METHODS
  Six dogs (9.8 +/- 0.8 kg) were anesthetized and intubated. The animals' lungs were ventilated with a tidal volume of 137 +/- 34 ml and a respiratory frequency of 34 +/- 10 breaths/min to produce a PaCO2 of 35 to 45 mm Hg. Application of 20 cm H2O of PEEP was initiated for 1 minute, then repeated twice after 10-minute stabilization periods. Arterial pH and gas tensions were measured, and capnogram, airway gas flow, and airway pressure were recorded continuously. Airway gas flow was electronically integrated to calculate tidal volume.
  
  
  RESULTS
  Mean values before application of PEEP were as follows: pHa, 7.37 +/- 0.04 mm Hg; PaCO2, 37.1 +/- 3.2 mm Hg; PaO2, 93.4 +/- 1.6 mm Hg; and PETCO2, 32.0 +/- 3.5 mm Hg. Compliance of the ventilator circuit was 3.3 ml/cm H2O. Mean deflation lung-thorax compliance was 41.5 +/- 10.3 ml/cm H2O. After application of PEEP, no capnogram was reported for 1 to 6 breaths, an average of 2.7 +/- 1.8 breaths.
  
  
  CONCLUSIONS
  These results demonstrated that absence of gas flow immediately after the application of PEEP may transiently abolish a capnogram when the lung volume increases.
authors: Department of Anesthesiology, University of South Florida College of Medicine, Tampa 33612-4799.
authors: J R
authors: JR
authors: Bowie
authors: R A
authors: RA
authors: Smith
authors: J B
authors: JB
authors: Downs
mesh_terms: D000769:Anesthesia, Inhalation; D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis* / Q000097:blood; D004285:Dogs; D005652:Functional Residual Capacity; D006863:Hydrogen-Ion Concentration; D007442:Intubation, Intratracheal; D008170:Lung Compliance; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D011312:Pressure; D012123:Pulmonary Ventilation; D012119:Respiration; D013909:Thorax / Q000502:physiology; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen