Effects of p-chloroamphetamine (PCA) on ejaculation in aged rats.
In general, sexual activity in normal animals declines with increasing age. In aged male rats, for example, no ejaculation occurs when paired with receptive females. The ejaculatory response induced by p-chloroamphetamine (PCA) in aged adult rats, 14 to 18 months of age, was observed. The animals were treated intraperitoneally with PCA. The ejaculation rates were 0.28.6, 57.1 and 100% at doses of 0.3125, 0.625, 1.25 and 2.5 mg/kg, respectively. These animals, with a few exceptions, showed an ejaculation within 2 hrs of PCA injection. These data for aged adults are similar to those for young adults.
Saito
T R
TR
Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Hokao
R
R
Aoki
S
S
Wakafuji
Y
Y
Takahashi
K W
KW
D000375:Aging / Q000502:physiology*; D000818:Animals; D000830:Animals, Laboratory; D004542:Ejaculation / Q000187:drug effects*; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D010133:p-Chloroamphetamine