Early-onset leukopenia and severe thrombocytopenia following doxorubicin chemotherapy for tonsillar squamous cell carcinoma in a dog.
Doxorubicin is reported to cause myelosuppression, with a white blood cell count nadir occurring between day 7 and day 10. Thrombocytopenia is less severe and occurs between days 3 and 8. This report presents an early onset of leukopenia (day 5) and a severe thrombocytopenia (4000 platelets/microliter) (day 6) associated with doxorubicin administration for treatment of recurrent tonsillar squamous cell carcinoma in a dog.
Henry
C J
CJ
Department of Small Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5522.
Brewer
W G
WG
Stutler
S A
SA
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use*; D007958:Leukocyte Count / Q000662:veterinary; D007970:Leukopenia / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000662:veterinary; D010976:Platelet Count / Q000662:veterinary; D013921:Thrombocytopenia / Q000139:chemically induced / Q000662:veterinary*; D013997:Time Factors; D014067:Tonsillar Neoplasms / Q000188:drug therapy / Q000662:veterinary*
D004317:Doxorubicin