Pharmacologic intervention in ischemia-induced reperfusion injury in the skeletal muscle.
This article provides a concise review on the potential causes of ischemia-induced reperfusion (I/R) injury and pharmacologic intervention in the skeletal muscle. Special emphasis is placed on the recent observation of the acute ischemic preconditioning phenomenon for prevention of I/R injury in skeletal muscle. Finally, the mechanism of ischemic preconditioning and its clinical applications for augmentation of skeletal muscle tolerance to prolonged ischemic insult are discussed.
Pang
C Y
CY
Division of Surgical Research, Hospital for Sick Children, Toronto, Ontario, Canada.
Forrest
C R
CR
Mounsey
R
R
D000818:Animals; D006801:Humans; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology / Q000637:transplantation*; D010600:Pharmacology; D015427:Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology*; D013524:Surgical Flaps