Derivative (11)t(7;11)(q11;q24) in a child with acute megakaryoblastic leukemia.
We document the clinical, morphologic, and cytogenetic findings in a 2 1/2-year-old patient with acute megakaryoblastic leukemia. Cytogenetic analysis of peripheral blood leukemic cells revealed the presence of a der(11)t(7;11)(q11;q24). Chromosome 7 involvement is observed in nearly half of all cases of megakaryoblastic leukemias, however, the type of abnormality differs widely from one case to another. The der(11)t(7;11)(q11;q24) described here is the first reported to our knowledge.
Willem
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Department of Hematology, School of Pathology, University of the Witwatesrand Medical School, Parktown, South Africa.
Saragas
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D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D014178:Translocation, Genetic