Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats.
Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB binding sites, to the levels of those in a sham group, in a dose-dependent manner. Moreover, propentofylline (25 mg/kg, p.o.) significantly reduced the Bmax value of [3H]QNB binding sites compared with that in a vehicle-treated BF-lesioned group. These results suggest that successive administration of propentofylline ameliorates changes in muscarinic cholinergic receptors through improving presynaptic cholinergic dysfunction.
Fuji
K
K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Hiramatsu
M
M
Hayashi
S
S
Kameyama
T
T
Nabeshima
T
T
D000818:Animals; D001345:Autoradiography; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007051:Ibotenic Acid; D007700:Kinetics; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis; D010296:Parietal Lobe / Q000187:drug effects / Q000378:metabolism*; D016548:Prosencephalon / Q000502:physiology*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D014316:Tritium; D014970:Xanthines / Q000494:pharmacology*
D009414:Nerve Growth Factors; D011976:Receptors, Muscarinic; D014970:Xanthines; D014316:Tritium; D007051:Ibotenic Acid; C032114:propentofylline; D011813:Quinuclidinyl Benzilate