The use of recombinant human granulocyte macrophage colony-stimulating factor in autologous and allogeneic bone marrow transplantation.
In order to determine the effect of recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF), it has been administered to patients undergoing autologous or allogeneic bone marrow transplant (BMT). Results in patients undergoing autologous or allogeneic BMT indicate that rhGM-CSF is minimally toxic and is associated with reduced morbidity. Trials also indicate that rhGM-CSF may be an acceptable therapy for patients with marrow graft failure since survival appears to improve substantially in patients who received rhGM-CSF compared with historical control patients.
Nemunaitis
J
J
Veterans Affairs Medical Center, Seattle, Washington.
Singer
J W
JW
D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor