Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis.
Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC90 of ofloxacin against Pseudomonas aeruginosa.
Himmelfarb
M Z
MZ
Department of Otorhinolaryngology, Tel Aviv-Elias Sourasky Medical Center, Faculty of Medicine, University of Tel Aviv, Israel.
Zikk
D
D
Rapoport
Y
Y
Redianu
C
C
Shalit
I
I
D000284:Administration, Oral; D000368:Aged; D005260:Female; D006097:Granulation Tissue / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D010032:Otitis Externa / Q000378:metabolism* / Q000382:microbiology; D011552:Pseudomonas Infections
D015242:Ofloxacin