Sex-linkage of the chicken ornithine transcarbamylase gene.
The chicken ornithine transcarbamylase gene has been mapped to the short arm of the Z chromosome, near the centromere. Radioactive in situ hybridization was performed using a human cDNA clone, and chromosomes were scored for silver grain accumulation. This represents the first documented case of a mammalian X-linked gene also being sex-linked in an avian species. The significance of this finding in the context of sex chromosome evolution is briefly discussed. Further, differential sex-related OTC expression, whereby females (ZW) consistently produce higher levels of the enzyme than males (ZZ), must imply a peculiar mode of OTC transcription regulation.
Dominguez-Steglich
M
M
Department of Human Genetics, University of Würzburg, Germany.
Schmid
M
M
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007621:Karyotyping; D008297:Male; D009954:Ornithine Carbamoyltransferase / Q000235:genetics* / Q000378:metabolism; D014960:X Chromosome
D009954:Ornithine Carbamoyltransferase