title: Exercise tolerance is lower in type I diabetics compared with normal young men.
abstract: The present investigation was conducted to study metabolic and hormonal responses to prolonged exercise to exhaustion in insulin-dependent diabetic subjects. Sixteen healthy subjects (control) and 15 diabetics with no-insulin administration for 12 hours were studied. They were submitted to short-term exercise to exhaustion on a cycle ergometer at 55% to 60% of maximum oxygen consumption (VO2max). Exercise tolerance was significantly lower in diabetic subjects (66 +/- 6.7 v 117 +/- 9.4 minutes), and glucose concentration was significantly higher in these subjects. At exhaustion, only diabetic subjects showed a significant decrease in glycemia (142 +/- 20 v 111 +/- 16 mg/dL). Lactate concentration increased significantly during exercise up to 30 minutes, but at exhaustion only control subjects showed a reduction. No significant difference in free fatty acid (FFA) concentrations was observed between the groups during a 30-minute exercise period; however, at exhaustion levels were significantly higher in control subjects. Prolactin and C-peptide concentrations were significantly lower in diabetic subjects, whereas glucagon concentration was higher. No significant differences between the groups were observed for cortisol and growth hormone (GH) concentrations. We conclude that (1) diabetic subjects show reduced exercise tolerance when no insulin is administered for 12 hours, and (2) exercise to exhaustion reduces serum glucose concentrations in insulin-dependent diabetics.
authors: Physical Education School, Endocrinology Unit, University of São Paulo, Brazil.
authors: P R
authors: PR
authors: Ramires
authors: C L
authors: CL
authors: Forjaz
authors: M E
authors: ME
authors: Silva
authors: J
authors: J
authors: Diament
authors: W
authors: W
authors: Nicolau
authors: B
authors: B
authors: Liberman
authors: C E
authors: CE
authors: Negrão
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D017079:Exercise Tolerance; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006003:Glycogen / Q000032:analysis; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D009132:Muscles / Q000737:chemistry; D012119:Respiration
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D019344:Lactic Acid; D006003:Glycogen