Novel antimycin antibiotics, urauchimycins A and B, produced by marine actinomycete.
Two novel antimycin antibiotics, urauchimycins A and B, were isolated from a fermentation broth of a Streptomyces sp. Ni-80. The strain was isolated from an unidentified sponge. Their chemical structures were determined by 2D NMR analysis. They are the first antimycin antibiotics which possess a branched side chain moiety. They exhibited inhibitory activity against morphological differentiation of Candida albicans.
Imamura
N
N
Shimizu Institute, Marine Biotechnology Institute Co., Ltd., Japan.
Nishijima
M
M
Adachi
K
K
Sano
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000968:Antimycin A / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D011161:Porifera / Q000382:microbiology*; D013302:Streptomyces / Q000378:metabolism*; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; C080554:urauchimycin A; C080555:urauchimycin B; D000968:Antimycin A