The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas.
The frequency of the GSTM1 0 polymorphism at the glutathione S-transferase M1 locus has been determined in controls and patients with pituitary adenomas by using the polymerase chain reaction to amplify genomic DNA in the exon 4-5 region of the gene. The frequency of the genotype in patients with prolactinomas, non-functional adenomas, corticotrophinomas and somatotrophinomas varied between 52-67% compared with 44% in the controls. In the patients with prolactinomas the frequency of the genotype (67%) was significantly greater than in controls with odds ratio analysis indicating that GSTM1 0 individuals have a 2.56-fold greater risk of developing this adenoma.
Fryer
A A
AA
Centre for Pathology and Molecular Medicine, University of Keele, North Staffordshire Hospital Centre, Stoke-on-Trent, UK.
Zhao
L
L
Alldersea
J
J
Boggild
M D
MD
Perrett
C W
CW
Clayton
R N
RN
Jones
P W
PW
Strange
R C
RC
D000236:Adenoma / Q000201:enzymology* / Q000235:genetics; D001483:Base Sequence; D004273:DNA, Neoplasm / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016017:Odds Ratio; D010911:Pituitary Neoplasms / Q000201:enzymology* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015175:Prolactinoma / Q000201:enzymology* / Q000235:genetics; D006113:United Kingdom
D004273:DNA, Neoplasm; D005982:Glutathione Transferase