Cardiovascular abnormalities in children with fragile X syndrome.
It has been suggested by several authors that the prevalence of mitral valve prolapse and aortic root dilation is increased in individuals with the fragile X syndrome. The prevalence of these abnormalities in young children with fragile X has not been established. Sixteen boys and 1 girl 13 years or younger were studied. Only 1 child (6%) had the typical examination findings of mitral valve prolapse, although his echocardiogram was normal. From this study it appears that cardiac abnormalities in fragile X syndrome develop in late childhood and adolescence. It seems important to follow these children carefully so that these cardiac abnormalities can be documented when they do develop.
Crabbe
L S
LS
Department of Pediatrics, Cincinnati Center for Developmental Disorders, OH 45229.
Bensky
A S
AS
Hornstein
L
L
Schwartz
D C
DC
D000293:Adolescent; D001011:Aorta / Q000002:abnormalities; D002648:Child; D002675:Child, Preschool; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D008945:Mitral Valve Prolapse / Q000209:etiology*