A foreshortened method of measuring liquid gastric emptying in normal volunteers.
The purpose of this study was to compare the cumulative fraction absorbed-time profile method of paracetamol with the shorter proportional area under the curve method of paracetamol by pretreating normal volunteers with cisapride, codeine and metoclopramide with and without neostigmine. Both methods are sensitive and comparable in defining early phase liquid gastric emptying, with the proportional area under the curve method having the advantage of providing the relevant information with a two-hour study period.
van Wyk
M
M
Department of Pharmacology, University of Pretoria, South Africa.
Sommers
D K
DK
Snyman
J R
JR
Moncrieff
J
J
D000082:Acetaminophen / Q000493:pharmacokinetics; D000328:Adult; D020117:Cisapride; D003061:Codeine / Q000494:pharmacology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D008875:Middle Aged; D009388:Neostigmine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology
D010880:Piperidines; D012702:Serotonin Antagonists; D000082:Acetaminophen; D009388:Neostigmine; D008787:Metoclopramide; D020117:Cisapride; D003061:Codeine