Nerve growth factor revisited.
Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase, as a receptor and (3) it shares homology with at least three other factors, now collectively called neurotrophins, which have a spectrum of target cells.
Bradshaw
R A
RA
Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717.
Blundell
T L
TL
Lapatto
R
R
McDonald
N Q
NQ
Murray-Rust
J
J
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation; D000090063:Proto-Oncogene Mas; D017475:Receptors, Nerve Growth Factor / Q000737:chemistry; D013329:Structure-Activity Relationship
C000715470:MAS1 protein, human; D009414:Nerve Growth Factors; D000090063:Proto-Oncogene Mas; D017475:Receptors, Nerve Growth Factor