Effect of ascorbic acid administration on B and E apoproteins in rats fed a cholesterol enriched diet.
The effect of ascorbic acid on cholesterol metabolism is very well documented; it is ascribed to the activation of this vitamin on cholesterol 7 alpha-hydroxylase (EC 1.14) that activates the catabolism of cholesterol. In this paper we have studied the effect of the administration of ascorbic acid on B and E apoproteins of rats fed a diet enriched with 1.5% of cholesterol. The results obtained show that ascorbic acid is able to affect cholesterol metabolism by modifying the serum levels of apo B in total serum and in lipoprotein classes of density less than 1.050 g/ml. Moreover the ascorbic acid treatment reduced the amount of cholesterol and triglycerides in all lipoprotein classes examined. No significant change of total serum apo E was observed following ascorbic acid administration.
Santillo
M
M
Institute of Human Physiology, Second Faculty of Medicine and Surgery, University of Naples, Italy.
Santangelo
F
F
Belfiore
A
A
Mastursi
M
M
Mondola
P
P
D000818:Animals; D001055:Apolipoproteins B / Q000097:blood / Q000187:drug effects*; D001057:Apolipoproteins E / Q000097:blood / Q000187:drug effects*; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D005779:Immunodiffusion / Q000379:methods; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D001055:Apolipoproteins B; D001057:Apolipoproteins E; D002791:Cholesterol, Dietary; D014280:Triglycerides; D002784:Cholesterol; D001205:Ascorbic Acid