A method for testing the nonrandomness of chromosomal breakpoints.
Testing the nonrandomness of breakage at a chromosome band is an essential step fo identifying a fragile site. In this paper, we propose a method derived by using the relationship between the binomial and F distributions for testing nonrandomness. The method is simple in calculation. It was applied to the detection of fragile sites for Chinese patients with colorectal carcinoma.
Tai
J J
JJ
Institute of Statistical Science, Academia Sinica, Taipei, Taiwan Republic of China.
Hou
C D
CD
Wang-Wuu
S
S
Wang
C H
CH
Leu
S Y
SY
Wuu
K D
KD
D002277:Carcinoma / Q000235:genetics; D002681:China; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D015179:Colorectal Neoplasms / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D008677:Metaphase; D011336:Probability
D004273:DNA, Neoplasm