Characterization of the rhesus macaque (Macaca mulatta) equivalent of HLA-F.
Nucleotide sequence analysis of rhesus macaque major histocompatibility complex class I cDNAs allowed the identification of the orthologue of HLA-F, designated Mamu-F. Comparison of Mamu-F with earlier published human and chimpanzee orthologues demonstrated that these sequences share a high degree of similarity, both at the nucleotide and amino acid level, whereas a New World monkey (cotton-top tamarin) equivalent is more distantly related. Exon 7, encoding one of the cytoplasmatic domains, is absent for all primate Mhc-F cDNA sequences analyzed so far. In contrast to the human, chimpanzee, and rhesus macaque equivalents, the cotton-top tamarin Saoe-F gene seems to have accumulated far more nonsynonymous than synonymous differences.
Otting
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Department of Chronic and Infectious Diseases, ITRI-TNO, Rijswijk, The Netherlands.
Bontrop
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics* / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D006680:HLA Antigens; C062341:HLA-F antigens; D015395:Histocompatibility Antigens Class I