title: A method for testing the nonrandomness of chromosomal breakpoints.
abstract: Testing the nonrandomness of breakage at a chromosome band is an essential step fo identifying a fragile site. In this paper, we propose a method derived by using the relationship between the binomial and F distributions for testing nonrandomness. The method is simple in calculation. It was applied to the detection of fragile sites for Chinese patients with colorectal carcinoma.
authors: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan Republic of China.
authors: J J
authors: JJ
authors: Tai
authors: C D
authors: CD
authors: Hou
authors: S
authors: S
authors: Wang-Wuu
authors: C H
authors: CH
authors: Wang
authors: S Y
authors: SY
authors: Leu
authors: K D
authors: KD
authors: Wuu
mesh_terms: D002277:Carcinoma / Q000235:genetics; D002681:China; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D015179:Colorectal Neoplasms / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D008677:Metaphase; D011336:Probability
chemical_list: D004273:DNA, Neoplasm