Identification of nonsteroidal antiinflammatory drug-induced gastroduodenal injury in children with juvenile rheumatoid arthritis.
In a cohort of children with juvenile rheumatoid arthritis treated with nonsteroidal antiinflammatory drugs and referred for gastrointestinal complaints, more than 75% had gastritis, antral erosions, or ulcers. Epigastric pain strongly correlated with documented gastroduodenal injury. Therapy with ranitidine or misoprostol led to clinical improvement. Nonsteroidal antiinflammatory drugs are associated with significant gastrointestinal abnormalities in children.
Mulberg
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AE
Division of Pediatric Gastroenterology and Nutrition, Boston Floating Hospital for Infants and Children, New England Medical Center, MA 02111.
Linz
C
C
Bern
E
E
Tucker
L
L
Verhave
M
M
Grand
R J
RJ
D015746:Abdominal Pain / Q000209:etiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D015331:Cohort Studies; D004382:Duodenitis / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D005756:Gastritis / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D010865:Pilot Projects; D011899:Ranitidine / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016595:Misoprostol; D011899:Ranitidine