title: Synthesis, characterization and biodistribution of new 99mTc Oxo and nitrido complexes of unsaturated tetradentate (N2S2)ligands.
abstract: Three unsaturated Schiff base tetradentate (N2S2 or N2SO) ligands were synthesized and characterized. Oxo and nitrido 99m-technetium complexes were obtained with these ligands. The nitrido complexes were formed using a new easy method available as a kit. When injected into rats and mice, these lipophilic complexes were able to cross the blood-brain barrier but brain perfusion imaging could not be performed due to the insufficient uptake and retention time.
authors: Laboratoire de Biophysique et de Médecine Nucléaire, Faculté de Médecine Toulouse-Purpan, France.
authors: Y
authors: Y
authors: Coulais
authors: G
authors: G
authors: Cros
authors: M H
authors: MH
authors: Darbieu
authors: P
authors: P
authors: Gantet
authors: J A
authors: JA
authors: Tafani
authors: D
authors: D
authors: Vende
authors: R
authors: R
authors: Pasqualini
authors: R
authors: R
authors: Guiraud
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012545:Schiff Bases / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D008024:Ligands; D015609:Organotechnetium Compounds; D012545:Schiff Bases