T-cell receptor beta-chain binding to enterotoxin superantigens.
The last few years have seen an enormous jump in our knowledge and understanding of T-cell activation by superantigens. Clearly, a great number of infectious and parasitic organisms utilize superantigens as part of a strategy to evade the immune response of their host. The ability to modulate superantigen effects will give us new means to fight infections, and the knowledge of T-cell activation that we have gained from study of superantigens will, in turn, allow us to modulate the immune system in new ways.
Irwin
M J
MJ
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
Hudson
K R
KR
Ames
K T
KT
Fraser
J D
JD
Gascoigne
N R
NR
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D004768:Enterotoxins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006684:HLA-DR Antigens / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D009154:Mutation; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000235:genetics / Q000276:immunology
D000942:Antigens, Bacterial; D004768:Enterotoxins; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta