The role of lipid peroxidation and calcium in galactosamine induced toxicity in the rat liver.
Liver homogenate and subcellular fractional levels of lipid peroxides, homogenate glutathione (GSH) and calcium contents and hepatic plasma membrane Ca(2+)-ATPase activity were determined in rats, 12, 18, 24 and 48 hours after treatment with a single dose of 1 g/kg galactosamine. Lipid peroxides and calcium levels in liver homogenate and subcellular fractions were found to increase, but hepatic GSH content and Ca(2+)-ATPase activity were observed to decrease reversibly.
Seçkin
S
S
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Koçak-Toker
N
N
Uysal
M
M
Oz
B
B
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005688:Galactosamine / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D008315:Malondialdehyde; D005688:Galactosamine; D000252:Calcium-Transporting ATPases; D005978:Glutathione; D002118:Calcium