Rhabdomyosarcoma. A cytogenetically interesting case report.
Chromosomal analysis was performed on the tumor tissue in a case of ocular rhabdomyosarcoma. Cytogenetic analysis revealed multiple clonal abnormalities. Derivative(5)t(1;5)(q21;q35) and t(2;11) (q21;q23) were present in all the metaphases analyzed (100%). Translocation(1;19)(q21;q13) was observed in 61% of the metaphases. Other clonal abnormalities present included +i(6p)(85%),i(17q)(38%),18q+(57%), 4p+ (38%), loss of the Y chromosome (33%), and presence of double minutes (12.8%).
Gladstone
B
B
Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
Parikh
P M
PM
Balsara
B
B
Kadam
P R
PR
Rao
S R
SR
Nair
C N
CN
Jambekar
N A
NA
Advani
S H
SH
D002675:Child, Preschool; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D005134:Eye Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D012208:Rhabdomyosarcoma / Q000235:genetics*; D014178:Translocation, Genetic