title: Effects of felbamate and other anticonvulsant drugs in two models of status epilepticus in the rat.
abstract: Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus. Felbamate was ten times more potent against pilocarpine-induced seizures in lithium-treated rats than in lithium-free animals. Diazepam, valproate and phenobarbital were effective in both the high dose pilocarpine and lithium-pilocarpine models. On the other hand, phenytoin was ineffective in both models, whereas carbamazepine displayed protective effects only in the lithium-pilocarpine model.
authors: Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, New Jersey 08512.
authors: R D
authors: RD
authors: Sofia
authors: R
authors: R
authors: Gordon
authors: M
authors: M
authors: Gels
authors: W
authors: W
authors: Diamantis
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D000078328:Felbamate; D008094:Lithium; D008297:Male; D048448:Phenylcarbamates; D010862:Pilocarpine; D011409:Propylene Glycols / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D013226:Status Epilepticus / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D010862:Pilocarpine; D008094:Lithium; D000078328:Felbamate