Flomoxef, a new oxacephem antibiotic, does not cause hemostatic defects.
Antibiotics of the beta-lactam class may cause coagulation defects and bleeding. It has been suggested that N-methyltetrazolethiol (NMTT), a common side chain group at the 3'-position of the cephem or 1-oxacephem frame, could be responsible for the hypoprothrombinemic effect of the antibiotics and that it could inhibit the liver vitamin K-epoxide reductase activity. Flomoxef (6315-S) is a new oxacephem antibiotic which differs from latamoxef because it has [1-(2-hydroxethyl)-1H-tetrazol-5-yl] thiomethyl (HTT) as a side chain at the 3'-position of cephem group instead of NMTT and an extensive modification of 7 beta-acylamino side chain. The present study was carried out to study its effects on vitamin K-dependent blood coagulation parameters in human volunteers. Ten adult patients (6 men and 4 women), suffering from chronic bronchitis, entered into the study. Each patient received ten 1 g i.m. injections of flomoxef at 12-hourly intervals. Apparently, the treatment with this oxacephem antibiotic had no significant effect. PT, PTT and fibrinogen remained in the normal range in all patients and factors II+VII+X, protein C, protein S and AT III were not depleted. The trend was similar both in men and women. Based on the results of the present study, we conclude that flomoxef is an antibiotic that does not exhibit an effect on blood coagulation, even in males.(ABSTRACT TRUNCATED AT 250 WORDS)
Cazzola
M
M
Institute of Pharmacology and Toxicology, Medical School, Secomo University, Naples, Italy.
Brancaccio
V
V
De Giglio
C
C
Paternò
E
E
Matera
M G
MG
Rossi
F
F
D000368:Aged; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001779:Blood Coagulation Factors / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001991:Bronchitis / Q000150:complications; D002511:Cephalosporins / Q000009:adverse effects* / Q000494:pharmacology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000187:drug effects; D017293:Protein S / Q000187:drug effects; D014812:Vitamin K / Q000378:metabolism
D001779:Blood Coagulation Factors; D002511:Cephalosporins; D011486:Protein C; D017293:Protein S; D014812:Vitamin K; C045693:flomoxef