[Protooncogene c-myc amplification and cell cycle analysis in human malignant tumors].
As predictors of tumor response by radiotherapy, tumor with or without c-myc amplification and DNA histogram pattern were analyzed and evaluated for patients' prognosis. There was no relation between c-myc amplification and DNA ploidy pattern in this study. These factors also showed no relation to response rate and survival. But all of the tumors with c-myc amplification and aneuploid pattern exhibited a complete response by radiotherapy. The tumors with c-myc amplification and aneuploid pattern may be more radiosensitive than without amplification and diploid. These data suggested that c-myc amplification and ploidy pattern might be a predictive parameter before radiotherapy.
Kita
M
M
Dept. of Radiology, Tokyo Women's Medical College.
Okawa
T
T
Hasegawa
N
N
Maruyama
I
I
Karasawa
K
K
Kaneyasu
Y
Y
Tanaka
M
M
D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000532:radiotherapy; D011003:Ploidies; D011379:Prognosis
D004273:DNA, Neoplasm