Characteristics and mechanisms of nocturnal asthma.
Nocturnal worsening of asthma is a very common and significant problem for the vast majority of all asthmatic patients. The involved mechanisms are multiple and interactive. These include circadian alterations in inflammation/mediators, epinephrine, beta 2 receptor function, vagal tone, and body temperature. Other factors may include aspiration, sinusitis, and sleep apnea. Understanding of the mechanisms involved in nocturnal asthma directs the therapeutic approach of these patients.
Martin
R J
RJ
University of Colorado Health Sciences Center, National Jewish Center for Immunology and Respiratory Medicine, Denver.
D000403:Airway Resistance; D001249:Asthma / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D001831:Body Temperature; D001980:Bronchi / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology; D002940:Circadian Rhythm; D005541:Forced Expiratory Volume; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology; D012137:Respiratory System / Q000378:metabolism; D014630:Vagus Nerve / Q000503:physiopathology