Pre-operative gonadotrophin-releasing hormone agonist treatment in surgery for uterine leiomyomata.
To determine whether pre-operative treatment with gonadotrophin-releasing hormone (GnRH) analogue may have a beneficial effect on surgery outcome, 53 patients with symptomatic fibroid uteri awaiting myomectomy or transabdominal hysterectomy (TAH), were randomly divided into a study group (n = 29) and a control group (n = 24). The study group of patients were treated by an i.m. injection of D-Trp6 LHRH microcapsules at 2 months and 1 month prior to surgery. The control group had no pre-operative treatment. Haemoglobin concentration and oestradiol, follicle-stimulating hormone and luteinizing hormone concentrations were measured at 2 months and 1 month prior to surgery, and at surgery. The duration of surgery was shorter in the study group (49 versus 70 min in the hysterectomy group) and intra-operative blood loss was less (208 versus 309 ml in the hysterectomies and 320 versus 476 ml in the myomectomies). Pre-operative treatment with GnRH-agonists which induces shrinkage of the uterus and fibroids is therefore efficient in shortening the duration of surgery, and diminishing the intra-operative blood loss in surgery for fibroid uteri. Such pre-operative treatment is therefore a useful addition to surgery in cases with symptomatic fibroid uteri.
Golan
A
A
Department of Obstetrics and Gynaecology, Assaf Harofeh Medical Centre, Zerifin, Israel.
Bukovsky
I
I
Pansky
M
M
Schneider
D
D
Weinraub
Z
Z
Caspi
E
E
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery*; D007986:Luteinizing Hormone / Q000097:blood; D011183:Postoperative Complications; D011300:Preoperative Care; D017329:Triptorelin Pamoate / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000601:surgery*
D006454:Hemoglobins; D017329:Triptorelin Pamoate; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone