[Maternal deficiency of IgG 2 and IgG 4 and neonatal infection caused by B-streptococci].
We describe here an newborn infant born in the 39th week of gestation with an early onset sepsis caused by group B streptococci. The intravenous administration of antibiotics and immunoglobulin preparation was unable to prevent the fatal outcome. The boy died after 16 hours of life. In the maternal serum a marked deficiency of IgG 2 and IgG 4 could be demonstrated. According to the results from the literature it seems possible that partial immunodeficiencies are important factors in the pathogenesis of the B-streptococcal disease of the newborn.
Maak
B
B
Kinderklinik, Thüringen-Klinik Georgius Agricola, Saalfeld GmbH.
Müller
E
E
Berbig
H
H
Estel
C
C
D016470:Bacteremia / Q000276:immunology*; D006801:Humans; D017099:IgG Deficiency / Q000276:immunology*; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis / Q000145:classification*; D007231:Infant, Newborn; D008297:Male; D013290:Streptococcal Infections / Q000276:immunology*; D013292:Streptococcus agalactiae / Q000276:immunology*
D007074:Immunoglobulin G
Mütterlicher Mangel an IgG 2 und IgG 4 und neonatale Infektion durch B-Streptokokken.