title: Cyclin synthesis: who needs it?
abstract: Studies of the G2 to M transition in amphibian oocytes, in combination with in vitro mitotic systems and yeast genetic analysis, have significantly contributed to our understanding of the mechanisms by which M-phase is regulated. Historically, oocyte maturation has provided a number of valuable initial observations, but the biochemical elucidation of cell cycle control mechanisms has proved more tractable in cell-free extracts of frog eggs which reproduce aspects of early embryogenic mitosis. Recent experiments examining the importance of protein synthesis in the maturing oocyte have highlighted some important differences between mitosis and meiosis. Additional controls found in meiosis but not embryonic mitosis, are similar to controls found in somatic cells. This suggests that understanding the differences, as well as the similarities, between meiosis in the oocyte and mitosis in the early embryo will help us to learn more about the way in which cells enter and leave mitosis.
authors: Department of Physiology, University of California, San Francisco 94143-0444.
authors: J
authors: J
authors: Minshull
mesh_terms: D000818:Animals; D016213:Cyclins / Q000096:biosynthesis*; D016200:Maturation-Promoting Factor / Q000737:chemistry / Q000502:physiology; D008540:Meiosis / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D009865:Oocytes / Q000502:physiology
chemical_list: D016213:Cyclins; D016200:Maturation-Promoting Factor