Sheehan's syndrome: clinical profile, pituitary hormone responses and computed sellar tomography.
Twenty patients with the typical clinical presentation of Sheehan's syndrome were studied. All had a severe degree of hypopituitarism. The circulating mean basal levels of thyroid hormones, cortisol and prolactin were significantly lower (p < 0.05 to < 0.02) compared to those in 50 age matched controls. The provoked pituitary responses to combined pituitary stimulation in 13 patients were markedly lower (p < 0.02 to < 0.001) than those in ten age matched control subjects. Sellar computed tomography revealed an empty sella in all the patients; partial in five and complete in the remaining. A secondary empty sella is considered a characteristic finding in the classical form of Sheehan's syndrome.
Dash
R J
RJ
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Gupta
V
V
Suri
S
S
D000293:Adolescent; D000328:Adult; D004652:Empty Sella Syndrome / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D010901:Pituitary Function Tests; D014057:Tomography, X-Ray Computed
D006728:Hormones