The glycosides of hydroxylysine are final products of collagen degradation in humans.
Glucosyl-galactosyl-hydroxylysine (GGHYL) and galactosyl-hydroxylysine (GHYL) are metabolites derived from collagen degradation. They are useful biochemical markers provided they are not further processed. Experiments were run to test the activity of alpha- and beta-glycosidases in human kidney cortex preparations. Results allow to exclude the presence of the specific enzymes, in contrast with what is reported for the rat kidney tissue.
Moro
L
L
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università degli Studi di Trieste, Italy.
Noris-Suarez
K
K
Michalsky
M
M
Romanello
M
M
de Bernard
B
B
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000378:metabolism; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley
D006901:Hydroxylysine; C001295:glucosylgalactosylhydroxylysine; C007817:galactosylhydroxylysine; D003094:Collagen; D006026:Glycoside Hydrolases