Benzodiazepines and their solvents influence neutrophil granulocyte function.
We have examined the effects of commercially available preparations and drug-free solvents of diazepam (Valium, Diazepam-Lipuro) and midazolam (Dormicum) by N-formylmethionyl-leucylphenylalanine (FMLP)- and zymosan-induced polymorphonuclear cell (PMN) chemiluminescence and in a cell-free chemiluminescence system. In the case of Valium, drug-free solvent and diazepam suppressed PMN chemiluminescence. With Diazepam-Lipuro, the solvent stimulated and diazepam inhibited PMN chemiluminescence. With midazolam (Dormicum), only the active drug depressed PMN chemiluminescence. FMLP-induced PMN chemiluminescence was depressed 10-100 fold more by diazepam and midazolam than zymosan-induced chemiluminescence.
Weiss
M
M
Department of Anaesthesia, Heinrich-Heine-University, Düsseldorf, Germany.
Mirow
N
N
Birkhahn
A
A
Schneider
M
M
Wernet
P
P
D003975:Diazepam / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008874:Midazolam / Q000494:pharmacology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000037:antagonists & inhibitors; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D012997:Solvents / Q000494:pharmacology; D015054:Zymosan
D012997:Solvents; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015054:Zymosan; D003975:Diazepam; D008874:Midazolam