title: Diagnostic features and clinical outcome of ischemic-type biliary complications after liver transplantation.
abstract: The clinical significance and outcome of nonanastomotic strictures and dilatations involving only the biliary tree of the graft with a radiological appearance of biliary ischemia is unknown. Therefore we analyzed the grafts of 128 patients to evaluate the biochemical, radiological and histological features that prompted the diagnosis of ischemic-type biliary stricture and the clinical outcome of this complication. Ischemic-type biliary strictures were diagnosed in 25 patients (19%). Initial graft function was similar in all patients, whether or not this complication developed. Most ischemic-type biliary strictures occurred between 1 and 4 mo after orthotopic liver transplantation. However, the appearance of ischemic-type biliary stricture in the month after transplantation was predictive for a poor outcome in all six grafts with early onset of ischemic-type biliary strictures. Eighteen patients (72%) were treated with biliary stents and repeated dilatations. Long-term patency was achieved in 88% of these patients. Repeat transplantation was performed in six patients (24%); five survived. Finally, patients with ischemic-type biliary strictures spent more time in the hospital during the first year after orthotopic liver transplantation than did patients without the complication (62 +/- 27 days vs. 37 +/- 20 days; p < or = 0.001). This was due to repeated hospitalizations and a higher incidence of retransplantation. One-year graft survival was lower in patients with ischemic-type biliary strictures than in patients without ischemic-type biliary strictures (69% vs. 88%; p = 0.006). However, 1-yr patient survival was similar in the two groups (91% vs. 89%). In conclusion, early appearance of ischemic-type biliary stricture features is associated with poor graft prognosis.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Section of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota 55905.
authors: L
authors: L
authors: Sanchez-Urdazpal
authors: G J
authors: GJ
authors: Gores
authors: E M
authors: EM
authors: Ward
authors: T P
authors: TP
authors: Maus
authors: E G
authors: EG
authors: Buckel
authors: J L
authors: JL
authors: Steers
authors: R H
authors: RH
authors: Wiesner
authors: R A
authors: RA
authors: Krom
mesh_terms: D000206:Actuarial Analysis; D001652:Bile Ducts / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology; D011183:Postoperative Complications / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D015607:Stents; D016019:Survival Analysis; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome