Relief of severe pulmonary hypertension after closure of a large ventricular septal defect using low dose inhaled nitric oxide.
A 16-month-old girl developed severe pulmonary hypertension after closure of a large ventricular septal defect. All conventional therapeutic measures failed; an attempt to add nitric oxide at a continuous low dose to the inspired gas allowed resolution of pulmonary hypertension and low cardiac output. This report documents that continuous inhalation of low dose nitric oxide is capable of selective resolution of pulmonary hypertension following cardiac surgery for a large septal defect in a child. This suggests that a transient dysfunction in the release of nitric oxide by the pulmonary endothelial cell is responsible for the vasoconstriction.
Berner
M
M
Unité de Soins Intensifs, Clinique de Pédiatrie, Genève, Switzerland.
Beghetti
M
M
Ricou
B
B
Rouge
J C
JC
Prêtre
R
R
Friedli
B
B
D000280:Administration, Inhalation; D001784:Blood Gas Analysis; D004452:Echocardiography; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging / Q000601:surgery*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D007223:Infant; D009569:Nitric Oxide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D011659:Pulmonary Gas Exchange / Q000187:drug effects
D009569:Nitric Oxide