title: Methylene chloride exposure in industrial workers.
abstract: Methods of environmental and biological monitoring were applied in order to evaluate exposure to methylene chloride in workers operating in a factory where this substance was used as a solvent. For the measurement of methylene chloride in environmental concentration, the ambient air was sampled by using personal passive dosimeters. The activated charcoal was desorbed with CS2 and injected into a gas chromatograph connected with a mass spectrometer. The biological monitoring of exposed workers was performed by determining the concentration of CO in alveolar air (CA, ppm) and methylene chloride in urine (Cu, mu/L). Immediately after the end of the exposure, a urine sample was collected avoiding solvent loss and using gas-tight samplers. Excretion level in urine was determined by using headspace gas chromatography linked to a mass spectrometer. The CO was determined at the end of the shift by using a portable instrument. A group of 20 workers (12 smokers and 8 nonsmokers) in the manufacturing plant were monitored. No significant correlation was observed among the CO of all subjects and the concentration of methylene chloride in ambient air. When those workers who smoked were removed from the analysis, a correlation between the methylene chloride concentration in air and the CO concentration in alveolar air was found. Significant linear correlation was found between the environmental concentration of methylene chloride in the breathing zone and methylene chloride concentration in urine.
authors: Fondazionc Clinica del Lavoro, IRCCS, Medical Centre of Pavia, Italy.
authors: S
authors: S
authors: Ghittori
authors: P
authors: P
authors: Marraccini
authors: G
authors: G
authors: Franco
authors: M
authors: M
authors: Imbriani
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D001944:Breath Tests; D002248:Carbon Monoxide / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods / Q000592:standards*; D005069:Evaluation Studies as Topic; D006801:Humans; D016014:Linear Models; D008297:Male; D008752:Methylene Chloride / Q000009:adverse effects / Q000032:analysis* / Q000652:urine; D008875:Middle Aged; D015203:Reproducibility of Results; D012907:Smoking / Q000009:adverse effects
chemical_list: D000395:Air Pollutants, Occupational; D008752:Methylene Chloride; D002248:Carbon Monoxide