The effect of oral ondansetron in the prevention of postoperative nausea and vomiting after major gynaecological surgery performed under general anaesthesia.
The efficacy and safety of ondansetron in preventing postoperative nausea and vomiting following major gynaecological surgery was evaluated in this multicentre, double-blind study. A total of 243 patients were randomised to receive three doses of oral ondansetron 8 mg or matching placebo at 8-hourly intervals, with the first dose being given an hour before surgery. A standard general anaesthetic technique was employed throughout. Nausea, vomiting and safety assessments were performed continuously during the 24 h postrecovery period. Of the 237 patients evaluated for efficacy, significantly fewer ondansetron 8 mg treated patients (65/117; 56%) experienced postoperative nausea and/or vomiting compared with placebo-treated patients (94/120; 78%) during the study period (p < 0.001). In addition, ondansetron 8 mg reduced the severity of nausea (p < 0.001) and the total number of vomiting episodes experienced (p < 0.001). Overall, ondansetron 8 mg was well tolerated and effective in preventing postoperative nausea and vomiting in this surgical setting.
Dupeyron
J P
JP
Département d'Anesthésie, CHU, Strasbourg, France.
Conseiller
C
C
Levarlet
M
M
Hemmingsen
C
C
Schoeffler
P
P
Pedersen
F M
FM
Gribomont
B
B
Kaplan
L A
LA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001530:Belgium; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D017294:Ondansetron / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control*; D014839:Vomiting / Q000517:prevention & control*
D017294:Ondansetron