Congenital adrenal hyperplasia with testicular tumors, aggression, and gonadal failure.
Bilateral testicular tumors (adrenal rests) may occur in untreated or poorly controlled congenital adrenal hyperplasia. This case report describes two unique associated phenomena: (1) psychologic disturbances similar to those seen with exogenous androgen abuse, which resolved with appropriate glucocorticoid suppression of androgen over-production by this abnormal adrenal/adrenal rest tissue; and (2) testicular failure which showed a partial, delayed recovery with corticosteroid therapy. The need for a careful history and biochemical screening for all patients with bilateral testicular tumors is reinforced.
Keely
E J
EJ
Department of Medicine, University of Manitoba, Winnipeg, Canada.
Matwijiw
I
I
Thliveris
J A
JA
Faiman
C
C
D000312:Adrenal Hyperplasia, Congenital / Q000150:complications*; D000314:Adrenal Rest Tumor / Q000150:complications; D000328:Adult; D000374:Aggression; D006801:Humans; D008297:Male; D013736:Testicular Neoplasms / Q000150:complications*; D013737:Testis / Q000503:physiopathology*