title: Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XIX: 4,4'-Phenylene-bis-sydnone imines.
abstract: Fourteen 4,4'-m-phenylene- and two 4,4'-p-phenylene-bis-sydnone imine hydrochlorides have been synthesized. All compounds exhibited good solubility in water. In the m-series the 3-(3-phenylpropyl)-derivative 5c and the 3-hexyl compound 5l showed antiplatelet activities at or below 10 mumol/L (IC50, Born-test with collagen). The corresponding p-compounds had the same (6l) or slightly lower (6c) activity. No effect on the fibrin formation (Quick-test) could be observed.
authors: Institut für Pharmazie der Freien Universität Berlin, Germany.
authors: K
authors: K
authors: Rehse
authors: M
authors: M
authors: Kämpfe
authors: A
authors: A
authors: Martens
mesh_terms: D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013558:Sydnones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D013558:Sydnones