Effect of nifedipine on kidney and ureteral function after experimental acute unilateral ureteral obstruction.
Nifedipine, a calcium channel blocker, was tested for its in vivo effect on the ureter and kidney during acute obstruction. There was no discernible effect on peristalsis but glomerular filtration rate was improved. Thus, nifedipine would not be expected to decrease renal colic from obstruction.
Ghoniem
G M
GM
Department of Urology, Tulane University School of Medicine, New Orleans.
Dilworth
J P
JP
Roberts
J A
JA
D000818:Animals; D003085:Colic / Q000188:drug therapy; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000503:physiopathology; D009543:Nifedipine / Q000494:pharmacology*; D010215:Papio; D011866:Radioisotope Renography; D012079:Renal Circulation / Q000187:drug effects; D014513:Ureter / Q000187:drug effects* / Q000503:physiopathology; D014517:Ureteral Obstruction / Q000503:physiopathology*
D009543:Nifedipine