title: Increased specificity of antibody detection in surgical patients with invasive candidiasis with cytoplasmic antigens depleted of mannan residues.
abstract: In this study, it was shown that the diagnostic accuracy of antibody detection by a counterimmunoelectrophoresis technique could be improved by using cytoplasmic antigens depleted of mannan residues. The specificity of the counterimmunoelectrophoresis increased from 28.6 to 78.6% when cytoplasmic antigens depleted of mannan were used, while the sensitivity slightly decreased from 80 to 70%.
authors: Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands.
authors: A J
authors: AJ
authors: van Deventer
authors: H J
authors: HJ
authors: van Vliet
authors: L
authors: L
authors: Voogd
authors: W C
authors: WC
authors: Hop
authors: W H
authors: WH
authors: Goessens
mesh_terms: D000908:Antibodies, Fungal / Q000097:blood*; D000946:Antigens, Fungal / Q000737:chemistry / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis*; D003378:Counterimmunoelectrophoresis; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D008351:Mannans / Q000276:immunology; D012680:Sensitivity and Specificity
chemical_list: D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D008351:Mannans