[Protection by zinc acexamate against gastric lesions induced by non-steroid anti-inflammatory agents].
The ability of different non-steroidal anti-inflammatory drugs (diclofenac, indomethacin, ketoprofen, naproxen and piroxicam) to inhibit gastric prostaglandin E2 production in the rat was compared with their damaging potential on gastric mucosa. The influence of treatment with zinc acexamate (ZAC) on these two parameters was also determined. ZAC treatment significantly decreased the degree of gastric damage elicited by all the antiinflammatories tested. The experimental data confirm the complexity of the gastrolesive effect exerted by anti-inflammatory drugs and that only part of such effect would be related with their inhibition of prostaglandin synthesis. These results indicate that the gastroprotection of ZAC does not exclusively depend on the effect on the synthesis of prostaglandins by the gastric mucosa, yet it can additionally be exerted through alternative mechanisms.
Navarro
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Departamento de Farmacología, Laboratorios Viñas, S.A., Barcelona.
Bravo
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L
Bulbena
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O
D000614:Aminocaproates; D015119:Aminocaproic Acid / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D005260:Female; D005753:Gastric Mucosa / Q000000981:diagnostic imaging / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014463:Ultrasonography
D000614:Aminocaproates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; C018802:6-acetylaminocaproic acid; D015232:Dinoprostone; D015119:Aminocaproic Acid
Protección del acexamato de zinc frente a lesiones gástricas inducidas por antiinflamatorios no esteroideos.