title: Dental extractions in patients with bleeding disorders. The use of fibrin glue.
abstract: Eighty patients with various bleeding disorders underwent 135 extractions without preventive replacement hematologic therapy. The local hemostatic control involved the use of fibrin glue Beriplast. Secondary bleeding occurred in 9 of 12 patients with severe hemophilia when the concentration of the aprotinin in the fibrin glue was 1,000 KIU/ml. When it was increased to 10,000 KIU/ml and swish and swallow rinses of tranexamic acid before and after the dental extractions were added, only 3 of 25 hemophilia patients suffered from secondary bleeding. Local use of fibrin glue is a safe and cost-effective tool to treat patients with severe bleeding disorders. None of the 43 patients with coagulopathies other than severe hemophilia suffered bleeding after extractions.
authors: Division of Pediatric and Hospital Dentistry, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors: M
authors: M
authors: Rakocz
authors: A
authors: A
authors: Mazar
authors: D
authors: D
authors: Varon
authors: S
authors: S
authors: Spierer
authors: D
authors: D
authors: Blinder
authors: U
authors: U
authors: Martinowitz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D003730:Dental Care for Persons with Disabilities; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D014081:Tooth Extraction
chemical_list: D015718:Fibrin Tissue Adhesive