title: Crystal structure of artemisinic acid: a possible biogenetic precursor of antimalarial artemisinin from Artemisia annua.
abstract: Artemisinic acid [1], a possible biogenetic precursor of the antimalarial artemisinin [2], was isolated from the hexane extract of Artemisia annua. X-ray crystallography of the dimer of artemisinic acid shows that the cyclization during intermolecular hydrogen bonding occurs by the opposite orientation of the alpha, beta-methylene group in each molecule. Complete spectroscopic data of 1 are also given.
authors: Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
authors: L N
authors: LN
authors: Misra
authors: A
authors: A
authors: Ahmad
authors: R S
authors: RS
authors: Thakur
authors: H
authors: H
authors: Lotter
authors: H
authors: H
authors: Wagner
mesh_terms: D000962:Antimalarials / Q000737:chemistry*; D037621:Artemisinins; D003460:Crystallization; D003500:Cyclization; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C047721:artemisic acid; C031327:artemisinin