title: Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice.
abstract: Effects of moniliformin on the ultrastructure of the myocardium of mice and rats were studied. Mice were given moniliformin orally at a dose of 29.46 mg.kg-1 the LD50. One h after dosing, lesions of the mitochondria of the myocardial cells were found which became more severe in 2 and 3 h. Ultrastructural lesions were also observed in the myofibrils and sarcolemma. Rats were given moniliformin orally at the dosage of 6 mg.kg-1 once daily for 56 d. Lesions of mitochondria and myofibrils were relatively mild. In the myocardiac specimens taken from the 21d post-toxin administration, lesions of the sarcolemma became more obvious. These moniliformin-induced lesions were similar to the ultrastructural changes in the myocardium of patients with Keshan disease. Our findings indicate that there may be a close and important relationship between moniliformin intoxication and Keshan disease.
authors: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
authors: D
authors: D
authors: Zhao
authors: Q
authors: Q
authors: Feng
authors: X
authors: X
authors: Yan
authors: C
authors: C
authors: Li
authors: Y
authors: Y
authors: Pan
authors: Q
authors: Q
authors: Cui
mesh_terms: D000818:Animals; D003503:Cyclobutanes / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects / Q000648:ultrastructure*; D009206:Myocardium / Q000648:ultrastructure*; D009210:Myofibrils / Q000187:drug effects / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D012508:Sarcolemma / Q000187:drug effects / Q000648:ultrastructure*
chemical_list: D003503:Cyclobutanes; C008539:moniliformin