Anticardiolipin syndrome, aspirin therapy and fetal malformation.
A patient with systemic lupus erythematosus and elevated cardiolipin antibody levels was given low-dose aspirin therapy prior to and throughout her third pregnancy to minimize the risk of miscarriage. She delivered a boy at 38 weeks with the skeletal deformity of two thoracic hemivertebrae. The putative role of aspirin causing this birth defect is discussed.
Chakravarty
K
K
Department of Rheumatology, Norfolk & Norwich Hospital, UK.
Merry
P
P
D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D001241:Aspirin / Q000009:adverse effects*; D005260:Female; D006053:Goldenhar Syndrome / Q000139:chemically induced / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007238:Infarction / Q000517:prevention & control; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D008297:Male; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011859:Radiography; D013131:Spine / Q000002:abnormalities*
D017153:Antibodies, Anticardiolipin; D001241:Aspirin