Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation.
Pharmacological modulation of ATP sensitive potassium channels (K+ATP channels) in vivo may influence ischemia and reperfusion injury of myocardium. The purpose of this investigation was to ascertain the actions of multiple K+ATP channel openers and interactions with a K+ATP channel antagonist in a model of stunned myocardium in anesthetized and conscious dogs. The results indicate that the K+ATP channel openers, aprikalim and nicorandil, enhance recovery of regional contractile function of stunned myocardium. This action was blocked by the selective K+ATP antagonist, glyburide. The beneficial effects of K+ATP channel openers were not related to changes in systemic hemodynamics or coronary collateral perfusion, but instead may be a manifestation of direct cardioprotective actions of these compounds.
Warltier
D C
DC
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
Auchampach
J A
JA
Gross
G J
GJ
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D005905:Glyburide / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology*; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D020108:Nicorandil; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
D015221:Potassium Channels; D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil; D000255:Adenosine Triphosphate; D005905:Glyburide