title: Subjective reward magnitude of medial forebrain stimulation as a function of train duration and pulse frequency.
abstract: The growth of the subjective reward magnitude of medial forebrain bundle stimulation in the rat (Sprague-Dawley) as a function of train duration and pulse frequency was measured in 2 ways: (a) a titration method, which used differences in rate of reward on 2 levers to compensate for differences in the magnitude of the rewards; and (b) a direct method, in which the ratio of the reward magnitudes at the 2 levers was assumed to be given by the ratio of times spent on each lever. The results of the 2 methods agree. Reward magnitude grows as approximately a power function of train duration up to train durations of about 1 s, then declines somewhat over the interval from 2-20 s. The exponent of growth varies from 0.4 to 2.3. With stronger stimulation (higher pulse frequency), peak reward magnitude is bigger, but the saturating train duration is approximately the same.
authors: Department of Psychology, University of California, Los Angeles 90024-1563.
authors: T A
authors: TA
authors: Mark
authors: C R
authors: CR
authors: Gallistel
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001931:Brain Mapping; D004558:Electric Stimulation / Q000379:methods; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology*; D009042:Motivation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D012653:Self Stimulation / Q000502:physiology*