Single-blind study of dystrophin staining in carriers of Duchenne muscular dystrophy.
A single-blind study of dystrophin staining in skeletal muscle was performed in 13 biopsies from carriers of Duchenne Muscular Dystrophy (DMD) and controls. The results indicate that immunohistochemical analysis of dystrophin staining is a valuable diagnostic test for DMD carriers when DNA for testing is unavailable from critical family members or is uninformative, when creatine kinase (CK) values are conflicting or when CK values must be used in isolation.
Bernier
F P
FP
Department of Pediatrics & Child Health, University of Manitoba, Winnipeg, Canada.
Greenberg
C R
CR
Halliday
W C
WC
Wrogemann
K
K
D000328:Adult; D003402:Creatine Kinase / Q000378:metabolism; D004247:DNA / Q000032:analysis / Q000235:genetics; D016189:Dystrophin / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism / Q000473:pathology; D009136:Muscular Dystrophies / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016037:Single-Blind Method
D016189:Dystrophin; D004247:DNA; D003402:Creatine Kinase