title: [A study of crossed cerebellar diaschisis on 123I-IMP SPECT images and its redistribution phenomenon].
abstract: Crossed cerebellar diaschisis (CCD) is interpreted as a functional deactivation, presumably caused by a loss of excitatory or inhibitory afferent inputs on the corticopontocerebellar pathway and others. A redistribution phenomenon (RD) is usually observed in the contralateral cerebellum with CCD on delayed images of 123I-IMP SPECT. This phenomenon was analyzed in a view point of rCBF measurement in 24 patients with brain tumor, infarction and so forth. Regional CBF was measured by the microsphere method with 123I-IMP and a delayed-to-early counts ratio (D/E ratio) was used. As a result, there was no relation between rCBF and the D/E ratio in the cerebellum, which means that RD is occurred by other factors except for rCBF in the cerebellum. Regional CBF and the D/E ratio in the contralateral and ipsilateral cerebellum was 46.3 ml/100 g/min, 1.01 and 57.0 ml/100 g/min, 0.86, respectively. These results mean that the high activity of IMP gradually decreased in the ipsilateral cerebellum, while, the low activity in the contralateral cerebellum was almost stable, and the difference of both activity reduced after 5 hours and RD was observed on the delayed image. The data indicate that retention mechanism of IMP and vascular permeability are not affected in the cerebellum with CCD.
authors: Department of Radiology, Niigata University School of Medicine.
authors: I
authors: I
authors: Odano
authors: N
authors: N
authors: Takahashi
authors: M
authors: M
authors: Nishihara
authors: M
authors: M
authors: Okubo
authors: H
authors: H
authors: Otaki
authors: E
authors: E
authors: Noguchi
authors: Y
authors: Y
authors: Yamazaki
authors: M
authors: M
authors: Kimura
authors: K
authors: K
authors: Sakai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000662:Amphetamines / Q000493:pharmacokinetics; D002526:Cerebellar Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002531:Cerebellum / Q000098:blood supply* / Q000378:metabolism; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine