Reproducibility of motor effects induced by successive subcutaneous apomorphine injections in Parkinson's disease.
We performed a crossover study of apomorphine-induced motor response reproducibility in 10 parkinsonian patients with the "on-off" phenomenon. On 2 separate days, each patient received two successive identical s.c. apomorphine injections, the second injection being randomly administered either 10 or 80 min after the end of the first apomorphine-induced motor benefit. Latency (12.3 +/- 4.5 min) and duration (61.9 +/- 13.3 min) of motor effects were similar in all tests. A transient worsening of the parkinsonian state after a motor improvement induced by apomorphine occurred in most of the patients. Therefore, the duration and severity of the "off" period after a motor improvement does not seem to influence the efficacy of a second apomorphine administration.
Gervason
C L
CL
Department of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology U 318, Joseph Fourier University of Grenoble, France.
Pollak
P R
PR
Limousin
P
P
Perret
J E
JE
D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D004294:Domperidone / Q000494:pharmacology; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology*
D004294:Domperidone; D001058:Apomorphine