title: 5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners.
abstract: A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in tumor cells from the fermentation broth and mycelia of a strain of Aspergillus fischeri which we have designated var. brasiliensis. The structures of three components were determined employing 1-D and 2-D homonuclear and heteronuclear NMR spectroscopy and mass spectrometry. The structure of 5-N-acetylardeemin was confirmed by single crystal X-ray diffraction. These compounds are most closely structurally related to asperlicin E1).
authors: Abbott Laboratories, Abbott Park, Illinois 60064.
authors: J E
authors: JE
authors: Hochlowski
authors: M M
authors: MM
authors: Mullally
authors: S G
authors: SG
authors: Spanton
authors: D N
authors: DN
authors: Whittern
authors: P
authors: P
authors: Hill
authors: J B
authors: JB
authors: McAlpine
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D004352:Drug Resistance, Microbial; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011744:Pyrimidinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D006571:Heterocyclic Compounds; D011744:Pyrimidinones; C080891:5-N-acetylardeemin