Experimental transmission of an apparent viral pneumonia in conventional and gnotobiotic pigs.
Endemic pneumonia in five- to eight-week-old pigs induced microscopic lesions of proliferative interstitial pneumonia which were compatible with a viral aetiology. The disease was transmitted experimentally to conventional and gnotobiotic pigs by means of a lung homogenate filtered through a 0.22 micron filter. No common viral respiratory pathogens of pigs were isolated. Two types of virus particles were observed in cell culture by electron microscopy; one was about 70 nm in diameter and had an envelope and short surface spicules, the other also had an envelope, was elongated, pleomorphic, measured 80 x 320 nm and was coated by antibodies.
Halbur
P G
PG
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Iowa State University, Ames 50011.
Paul
P S
PS
Andrews
J J
JJ
Sanderson
T P
TP
Ross
R F
RF
Schwartz
K J
KJ
Frey
M L
ML
Erickson
B J
BJ
Hill
H T
HT
Hoffman
L J
LJ
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002460:Cell Line; D002478:Cells, Cultured; D005856:Germ-Free Life; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008854:Microscopy, Electron; D011024:Pneumonia, Viral / Q000382:microbiology / Q000635:transmission / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000635:transmission*; D014771:Virion / Q000648:ultrastructure