Urinary excretion of metals during treatment with D-penicillamine and 2-mercaptopropionylglycine in normal and cystinuric dogs.
Urinary excretion of metals during treatment with 2-mercaptopropionylglycine (2-MPG) was studied in 11 normal and 20 cystinuric male dogs. The results were compared with those obtained during D-penicillamine treatment. Twenty-four-h urine and morning samples of urine were taken for determination of 13 metals before and during treatment. After single intravenous and oral D-penicillamine treatment of the normal dogs, significant increases were found in the 24-h urinary excretion of Ca, Cu and Zn. Oral intake of D-penicillamine increased the excretion of Co, Cr, Fe and Mg as well. No effect on renal metal excretion was observed after single intravenous and up to 2 months of daily oral treatment with 2-MPG. In 14 cystinuric dogs no effect was found after single intravenous and oral administrations of 2-MPG. However, after oral treatment of six cystinuric dogs with 2-MPG for 2-4 months, significantly increased excretions of Ca and Mg were found. Fourteen of the cystinuric dogs were also investigated after 2-6 years of continuous 2-MPG treatment, and after this period no significant elevation in the urinary excretion of metals was found. The present study shows that in contrast to D-penicillamine, 2-MPG does not increase the urinary excretion of metals to any appreciable extent. Observed increases in the excretion of Ca and Mg seemed to be a temporary effect only.
Hoppe
A
A
Department of Medicine and Surgery, Swedish University of Agricultural Sciences, Uppsala.
Denneberg
T
T
Frank
A
A
Kågedals
B
B
Petersson
L R
LR
D000284:Administration, Oral; D000818:Animals; D003404:Creatinine / Q000652:urine; D003555:Cystinuria / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs / Q000652:urine*; D007275:Injections, Intravenous; D008137:Longitudinal Studies; D008297:Male; D008670:Metals / Q000652:urine; D010396:Penicillamine / Q000627:therapeutic use*; D008625:Tiopronin / Q000627:therapeutic use*
D008670:Metals; D003404:Creatinine; D008625:Tiopronin; D010396:Penicillamine