[The protective effect of theophylline in exercise-induced asthma in childhood].
In order to study the protective effect of theophylline on exercise-induced asthma in children, we investigated the lung function of 16 children with documented bronchial asthma. Exercise provocation was performed by running on a treadmill for 6 minutes before and after two dose regimens of theophylline (10 and 20 mg/kg body weight). While for FEV1 the low dose regimen only showed a trend (p < 0.1), there was a slight but significant improvement in the high dose regimen (p < 0.05). Concerning sRaw both groups showed a small but significant improvement compared with the baseline values (p < 0.05). We conclude that in addition to its bronchodilatory effect theophylline may modulate exercise induced bronchospasm in asthmatic children.
Hoffmann-Streb
A
A
Universitätskinderklinik (KAVH), Berlin.
Niggemann
B
B
Büttner
P
P
Wahn
U
U
D000293:Adolescent; D000403:Airway Resistance / Q000187:drug effects; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D002648:Child; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D013806:Theophylline / Q000008:administration & dosage*
D013806:Theophylline
Untersuchungen zum protektiven Effekt von Theophyllin bei Anstrengungsasthma im Kindesalter.