Compliance of the respiratory system in newborn infants pre- and postsurfactant replacement therapy.
Surfactant administration causes a rapid and dramatic improvement in gas exchange, but paradoxically, studies have failed to show an improvement in the mechanical properties of the lung. We have measured dynamic and static (passive flow-volume technique) compliance before and after a single dose of bovine lipid extract surfactant in 22 premature infants with RDS. This had no effect on the measured dynamic compliance. In contrast, surfactant significantly increased static compliance from 0.41 +/- 0.02 to 0.55 +/- 0.04 mL/cm H2O/kg. This improvement was the result of a substantial recruitment of lung volume after surfactant administration. This led us to reduce ventilator pressures, which produced an increase in both dynamic and static compliance, but did not recruit additional volume. We conclude that surfactant causes a substantial increase in static compliance due to volume recruitment, which is consistent with reports of increase in the measured FRC. However, despite this improvement, the compliance is still below our normal range.
Kelly
E
E
Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
Bryan
H
H
Possmayer
F
F
Frndova
H
H
Bryan
C
C
D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008170:Lung Compliance / Q000187:drug effects*; D008176:Lung Volume Measurements; D008297:Male; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000503:physiopathology
D011663:Pulmonary Surfactants