title: Surgical treatment of corneal pathology in patients with Down's syndrome.
abstract: Keratoconus is a major cause of blindness in patients with Down's syndrome. A retrospective study of 30 corneal grafts for keratoconus in these patients revealed a 5-year graft survival of 67%. Postoperative trauma and/or infection was the main cause for graft failure. Conditions that should be met before the indication for corneal transplantation in a patient with Down's syndrome are formulated as a result of 15 years experience with that patient population. In appropriate cases, corneal transplantation may undoubtedly improve the quality of life in these patients.
authors: Diaconessenhuis, Leiden, The Netherlands.
authors: H J
authors: HJ
authors: Völker-Dieben
authors: M T
authors: MT
authors: Odenthal
authors: J
authors: J
authors: D'Amaro
authors: P J
authors: PJ
authors: Kruit
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003315:Cornea / Q000503:physiopathology / Q000601:surgery*; D016039:Corneal Transplantation; D004314:Down Syndrome / Q000150:complications*; D005128:Eye Diseases / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007640:Keratoconus / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged