title: [Multicenter study of HTLV-I and HTLV-II infection in Spain. Spanish Group for the Study of HTLV-II/II Infection].
abstract: BACKGROUND
  Human T-lymphotropic viruses type I (HTLV-I) and type II (HTLV-II) infections have been related to lymphoproliferative disorders and subacute neurological diseases. Screening blood donors for specific HTLV-I/II antibody has been implemented in Japan, United States, and recently in France. Should be it recommended in Spain?
  
  
  METHODS
  Antibodies to HTLV-I/II were investigated in sera from 7,884 individuals living in Spain. They were classified in four major groups: 1) subjects at high-risk for retrovirus infection, as drug addicts, homosexuals, and polytransfused individuals (n = 4,740), 2) patients suffering HTLV-like symptoms (n = 760), 3) immigrants from or travellers to endemic areas (n = 1,427), and 4) blood donors (n = 957).
  
  
  RESULTS
  Eighteen (0.22%) subjects were HTLV-I positive and 11 (0.12%) were classified as HTLV-II reactive. Five (71.5%) of 7 immigrants or travelers to endemic areas reacting against HTLV were typed as HTLV-I. Six (60%) of 10 drug addicts HTLV-reactive were typed as HTLV-II carriers.
  
  
  CONCLUSIONS
  Both HTLV-I and HTLV-II infections are present in Spain, although in a low rate and mostly restricted to drug addicts (HTLV-II), and people coming from endemic regions (HTLV-I). All tested blood donors were negative. In this view, HTLV-I/II screening in Spanish blood banks seems to be non urgent, although alternative strategies should be considered.
authors: Servicio de Enfermedades Infecciosas, Centro de Investigaciones Clínicas, Instituto de Salud Carlos III, Madrid.
authors: V
authors: V
authors: Soriano
authors: E
authors: E
authors: Calderón
authors: G
authors: G
authors: Cilla
authors: A
authors: A
authors: Aguilera
authors: F
authors: F
authors: Merino
authors: M
authors: M
authors: Gutiérrez
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000097:blood / Q000453:epidemiology*; D015482:HTLV-II Antibodies / Q000097:blood; D015491:HTLV-II Infections / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies
vernacular_title: Análisis multicéntrico de la infección por HTLV-I y HTLV-II en España. Grupo Español para el Estudio de la Infección HTLV-I/II.