title: Pathology of experimentally-induced, acute toxoplasmosis in macropods.
abstract: Thirteen Tammar wallabies (Macropus eugenii) were dosed orally with 500, 1000 or 10,000 oocysts of Toxoplasma gondii, as part of a vaccination trial. Eleven animals died of acute toxoplasmosis 9 to 15 days after challenge. The lesions were similar in all animals, consisting of foci of necrosis and inflammation in the intestines, lymphoid tissue, adrenal cortex, heart, skeletal muscle and brain, and severe generalised pulmonary congestion and oedema. Free and intracellular tachyzoites of Toxoplasma were associated with the lesions. The remaining 2 animals had shown no signs of disease when euthanased four months after challenge. Small, focal, non-suppurative inflammatory lesions were seen in brain, heart and skeletal muscle of these animals and chronic Toxoplasma infection was confirmed by mouse inoculation.
authors: Elizabeth Macarthur Agricultural Institute, Menangle, New South Wales.
authors: G L
authors: GL
authors: Reddacliff
authors: W J
authors: WJ
authors: Hartley
authors: J P
authors: JP
authors: Dubey
authors: D W
authors: DW
authors: Cooper
mesh_terms: D000818:Animals; D005260:Female; D007614:Macropodidae / Q000469:parasitology*; D008297:Male; D051379:Mice; D014124:Toxoplasmosis, Animal / Q000473:pathology*