Antibody-mediated neutropenia following bone marrow transplantation.
Unexpected neutropenia following allogeneic or autologous bone marrow transplantation may be caused by graft rejection, intrinsic stem cell failure, infection, graft-versus-host disease, relapse of the underlying neoplasm, or drug-induced myelosuppression. Over the past decade an increasing number of reports have documented that the differential diagnosis also includes antibody-mediated neutropenia, a syndrome distinct from conventional graft rejection. In contrast to many of the other common causes of unexpected post-transplant neutropenia, antibody-mediated neutropenia usually responds well to treatment with corticosteroids, plasma exchange, intravenous immunoglobulin, splenectomy, or other similar measures.
Klumpp
T R
TR
Comprehensive Cancer Center, Temple University, Philadelphia, PA 19140.
D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000503:physiopathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D009503:Neutropenia / Q000276:immunology* / Q000503:physiopathology
D001323:Autoantibodies; D007518:Isoantibodies