title: Successful treatment of cystinuria with captopril.
abstract: Cystinuria is an autosomal recessive hereditary disorder associated with nephrolithiasis and its attendant complications. Traditional management aimed at increasing urinary cystine solubility using oral alkali, D-penicillamine, or mercaptopropionyglycine is often unsuccessful due to intolerable side effects. Two cystinuric patients intolerant of traditional therapy were treated with captopril for 1 year, resulting in a marked decline in urinary cystine excretion. Neither patient experienced recurrent nephrolithiasis or adverse drug effects. Captopril should be considered an alternative to traditional drug management of cystinuria.
authors: Yale-Waterbury Primary Care Residency Program, St Mary's Hospital, Waterbury, CT 06702.
authors: M A
authors: MA
authors: Perazella
authors: G K
authors: GK
authors: Buller
mesh_terms: D000328:Adult; D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D003555:Cystinuria / Q000188:drug therapy*; D006801:Humans; D008297:Male
chemical_list: D002216:Captopril