Failure of iron chelators to protect against cerebral infarction in hypoxia-ischemia.
In this study the ability of iron chelators to attenuate hypoxic-ischemic brain damage was assessed in hyperglycemic rats that were exposed to 1% carbon monoxide and right carotid occlusion. The animals received deferoxamine (50 mg/kg), manganese-deferoxamine (50 mg/kg) or vehicle i.p. 0.5 h prior to hypoxemic-ischemic exposure and at 0.5, 3 and 24 h post-exposure; with subsequent histological examination of the brain at 7 days recovery. The area of cerebral infarction was measured at three levels using video imaging methods. The mean percentage of total hemisphere that was infarcted in the three groups was: vehicle--28.5 +/- 5.0; deferoxamine--31.7 +/- 12.1; and manganese deferoxamine--30.6 +/- 6.8 (p-n.s.). The results as obtained in this preliminary study indicate that aggressive pre- and post-treatment with iron chelators has no ability to attenuate cerebral infarction in this model.
MacMillan
V
V
Division of Neurology, University of Toronto, Ontario, Canada.
Fridovich
I
I
Davis
J
J
D000818:Animals; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications*; D002248:Carbon Monoxide; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003676:Deferoxamine / Q000627:therapeutic use; D002534:Hypoxia, Brain / Q000150:complications*; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D007502:Iron Chelating Agents; D002248:Carbon Monoxide; D003676:Deferoxamine