Tiapride versus metoclopramide: comparison after minor gynaecological surgery.
Tiapride (Tiapridal, Delagrange), a dopaminergic D2 receptor blocking agent having anxiolytic, sedative, antiemetic and analgesic properties was compared with metoclopramide and placebo in a randomized double-blind trial to determine its effects on post-operative nausea, vomiting, and sedation. The agents were given intravenously immediately before induction of anaesthesia to 75 women scheduled for minor elective gynaecological surgery. A standardized anaesthetic technique was used in all the patients. In the recovery room anti-emetic and sedative effects of tiapride and metoclopramide were similar and significantly better (P < 0.001) than placebo. In the ward at the end of 5 h anti-emetic (P < 0.05), and sedative (P < 0.01) effects of tiapride were significantly better than both metoclopramide and placebo.
Joshi
R
R
Department of Anaesthesia, Royal Hospital, Seeb, Sultanate of Oman.
Sivaganesanathan
A
A
D000027:Abortion, Incomplete / Q000601:surgery; D000030:Abortion, Missed / Q000601:surgery; D000293:Adolescent; D000328:Adult; D004107:Dilatation and Curettage / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008787:Metoclopramide / Q000627:therapeutic use*; D013511:Minor Surgical Procedures; D009325:Nausea / Q000517:prevention & control*; D010919:Placebos; D011183:Postoperative Complications / Q000517:prevention & control*; D011247:Pregnancy; D013976:Tiapamil Hydrochloride / Q000627:therapeutic use*; D014839:Vomiting / Q000517:prevention & control*
D006993:Hypnotics and Sedatives; D010919:Placebos; D008787:Metoclopramide; D013976:Tiapamil Hydrochloride