Diagnostic significance of skin immunolabelling with antibody against native cerebral amyloid in Alzheimer's disease.
Skin taken from patients with Alzheimer's disease (AD) and control patient groups were immunolabelled using antisera against either purified native cerebral beta protein or synthetic beta peptide. Native amyloid antiserum frequently labelled vascular walls in AD skin but rarely in control skin. Semi-quantitative analysis of the positive vessels showed a significant difference between the two groups. Sweat glands and dermal nerves were labelled in both groups. However, synthetic beta peptide antiserum showed no significant difference. Vascular wall labelling in skin with native amyloid antiserum is useful in the differential diagnosis of AD.
Ikeda
M
M
Department of Neurology, Gunma University School of Medicine, Maebashi, Japan.
Shoji
M
M
Yamaguchi
H
H
Matsubara
E
E
Amari
M
M
Ishiguro
K
K
Kawarabayashi
T
T
Harigaya
Y
Y
Hirai
S
S
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016612:Paraffin Embedding; D012867:Skin / Q000276:immunology*; D013545:Sweat Glands / Q000473:pathology
D016229:Amyloid beta-Peptides