title: (2R), (1'R) and (2R), (1'S)-2-amino-3-(1,2-dicarboxyethylthio)propanoic acids from Amanita pantherina. Antagonists of N-methyl-D-aspartic acid (NMDA) receptors.
abstract: An antagonist of NMDA-sensitive glutamate receptors in rat brain membrane and rat spinal motoneurones was isolated from Amanita pantherina and identified as a diastereoisomeric mixture of 2-amino-3-(1,2-dicarboxyethylthio)propanoic acids. The mixture was separated and the absolute configurations of the components were determined as (2R), (1'R) and (2R), (1'S), by analysis of the optical properties.
authors: Pharmaceutical Institute, Tohoku University, Sendai, Japan.
authors: S
authors: S
authors: Fushiya
authors: Q Q
authors: QQ
authors: Gu
authors: K
authors: K
authors: Ishikawa
authors: S
authors: S
authors: Funayama
authors: S
authors: S
authors: Nozoe
mesh_terms: D000545:Amanita / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; C017212:S-(1,2-dicarboxyethyl)cysteine; D003545:Cysteine