Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers.
Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.
Tsuchida
E
E
Department of Polymer Chemistry, Waseda University, Tokyo, Japan.
Nishide
H
H
Hasegawa
E
E
Chika
Y
Y
Fukuzumi
M
M
Komatsu
T
T
D002248:Carbon Monoxide / Q000378:metabolism; D006418:Heme / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D015394:Molecular Structure; D010100:Oxygen / Q000378:metabolism*; D013053:Spectrophotometry
D008051:Lipid Bilayers; D008081:Liposomes; D006418:Heme; D002248:Carbon Monoxide; D010100:Oxygen