Genetic models for the natural history of smoking: evidence for a genetic influence on smoking persistence.
We reanalyze data from the 1981 mailed questionnaire survey of the Australian twin register, to test for a genetic effect on smoking persistence (whether or not a smoker quits smoking). In the young cohort, aged 18-30 years, there are too few ex-smokers to permit resolution of genetic and non-genetic models. In the older cohort, we find a significant and substantial genetic effect on smoking persistence, accounting for 53% of the variance. This genetic effect on smoking persistence is independent of genetic effects on smoking initiation.
Heath
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AC
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Martin
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NG
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016739:Behavior, Addictive; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D012907:Smoking / Q000235:genetics*