[Synthesis of nucleoside analogs containing a cis-2-pentene fragment and their triphosphates].
Acyclic analogs of thymidine, adenine, and cytosine where the ribose moiety is replaced with cis-5-hydroxypenthene, were obtained via condensation of cis-5-acetoxy-1-bromo-2-pentene with nucleic acid bases. Triphosphate derivatives of the new nucleosides were also synthesized to evaluate their action as terminators of DNA synthesis catalyzed by DNA polymerases.
Mitsner
B I
BI
Kochetkov
M V
MV
Filippov
D V
DV
Tsytovich
A V
AV
Diatkina
N B
NB
D002384:Catalysis; D004247:DNA / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry; D009696:Nucleic Acids / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013728:Terminator Regions, Genetic
D009696:Nucleic Acids; D009705:Nucleosides; D004247:DNA; D004259:DNA-Directed DNA Polymerase
Sintez analogov nukleozidov, soderzhashchikh tsis-2-pentenovyĭ fragment, i ikh trifosfatov.