Cytokines and cancer cachexia.
A by-product of cancer (and of other chronic diseases or severe trauma), cachexia appears to be mediated by various cytokines. The first to be identified--tumor necrosis factor--may be a principal mediator. With molecular cloning techniques, future treatment strategies could include blockade of TNF activity using highly specific reagents.
Beutler
B
B
University of Texas, Dallas.
D000818:Animals; D002100:Cachexia / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha