Case report: cyclosporin A-induced neurotoxicity.
Acute encephalopathy is a recognized toxic effect of Cyclosporin A (CsA) in organ transplantation recipients. A 16-year-old girl presented with acute encephalopathy 2 weeks after CsA and methylprednisolone medication for idiopathic uveitis. Magnetic resonance imaging showed cortical and white matter occipital changes, which were not visible 2 months later. With expanding indication for CsA use, an increasing number of neurotoxic cases are to be expected.
Monteiro
L
L
Department of Neurology, Hospital Geral de Santo António, Oporto, Portugal.
Almeida-Pinto
J
J
Rocha
N
N
Lopes
G
G
Rocha
J
J
D000293:Adolescent; D002540:Cerebral Cortex / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects*; D004828:Epilepsies, Partial / Q000139:chemically induced; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000627:therapeutic use; D015866:Uveitis, Posterior / Q000188:drug therapy
D016572:Cyclosporine; D008775:Methylprednisolone