title: Isolation of <Glu-Asn-Phe-His-Leu-Arg-Pro-NH2 (Antho-RPamide II), a novel, biologically active neuropeptide from sea anemones.
abstract: Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide) we have isolated the neuropeptide <Glu-Asn-Phe-His-Leu-Arg-Pro-NH2 (Antho-RPamide II) from extracts of the sea anemone Anthopleura elegantissima. Addition of low concentrations of Antho-RPamide II to a tentacle preparation of sea anemones inhibited the spontaneous, rhythmic contractions, suggesting that the peptide is a neurotransmitter or neuromodulator.
authors: Center for Molecular Neurobiology (ZMNH), University of Hamburg, Germany.
authors: K
authors: K
authors: Carstensen
authors: I D
authors: ID
authors: McFarlane
authors: K L
authors: KL
authors: Rinehart
authors: D
authors: D
authors: Hudman
authors: F
authors: F
authors: Sun
authors: C J
authors: CJ
authors: Grimmelikhuijzen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D009068:Movement / Q000187:drug effects; D009479:Neuropeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011863:Radioimmunoassay; D012615:Sea Anemones / Q000737:chemistry*
chemical_list: D009479:Neuropeptides; C080964:Antho-RPamide II