[The formation of T-suppressors that suppress the activity of alloreactive T-cells after lymphocyte interaction with 2 different thymus-derived mediators].
The data are presented on simultaneous interaction of thymocytes and T-cells from lymph nodes with two humoral factors produced by macrophages and epithelial cells, main stromal elements of the thymus. Such contact of T-cells with two mediators resulted in the formation of T-suppressors capable of inhibiting the activity of syngeneic allospecific T-lymphocytes. These T-suppressors did not alter the response to another antigen but inhibited proliferation of donor cells. Involvement of such mechanism of T-suppressor formation in regulation of the immune status is discussed.
Anfalova
T V
TV
Lutsan
N I
NI
D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology; D006087:Graft vs Host Reaction / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013947:Thymosin / Q000031:analogs & derivatives*; D013949:Thymus Extracts / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology*; D014185:Transplantation, Isogeneic
D006023:Glycoproteins; D010455:Peptides; D013949:Thymus Extracts; C065652:timoptin; D013947:Thymosin
Obrazovanioe T-supressorov, podavliaiushchikh aktivnost' alloreaktivnykh T-kletok, pri vzaimodeĭstvii limfotsitov s dvumia razlichnymi mediatorami timusa.