title: Lymphocytes from the site of disease suggest adenovirus is one cause of persistent or recurrent inflammatory arthritis.
abstract: The assessment of synovial lymphocyte reactivity to adenovirus antigen stimulation was undertaken in patients with persistent or recurrent inflammatory arthritis. The 3H-thymidine uptake procedure was employed, incorporating multiple microbiological antigens. Five patients were found with repeated maximal responses to adenovirus antigen; in one of these adenovirus nucleotide sequences were present in a synovial biopsy specimen. It is concluded that adenovirus may be one cause of persistent or recurrent inflammatory arthritis.
authors: Department of Medicine, University of British Columbia, Vancouver, Canada.
authors: D K
authors: DK
authors: Ford
authors: H B
authors: HB
authors: Stein
authors: M
authors: M
authors: Schulzer
authors: E D
authors: ED
authors: Bateman
authors: J C
authors: JC
authors: Hogg
authors: S
authors: S
authors: Hayashi
mesh_terms: D017500:Adenovirus E1A Proteins / Q000032:analysis; D000258:Adenovirus Infections, Human / Q000150:complications* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001170:Arthritis, Infectious / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D001483:Base Sequence; D002648:Child; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008969:Molecular Sequence Data; D012008:Recurrence
chemical_list: D017500:Adenovirus E1A Proteins