Microbial reduction of aromatic carboxylic acids.
Several benzoic, cinnamic and phenylacetic acid derivatives were screened with 20 micro-organisms, mainly fungi, for the reduction of their carboxylic function. For all organisms several compounds were reduced in fairly good yields up to 80% to the corresponding alcohol. No general rule could be established, concerning the substitution pattern, as to which compounds were transformed to the alcohol. Generally the reactions were accomplished within 48-70 h. Only minor, if any, side products were detected. Dicarboxylic acids, such as phthalic or phenylglutaric acids and similar compounds could not be reduced by the microorganisms tested.
Arfmann
H A
HA
GBF, Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, Bundesrepublik Deutschland.
Abraham
W R
WR
D001231:Aspergillus flavus / Q000378:metabolism; D001234:Aspergillus niger / Q000378:metabolism; D001711:Biotransformation; D002934:Cinnamates / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000378:metabolism; D009168:Mycobacterium phlei / Q000378:metabolism*; D010084:Oxidation-Reduction; D010648:Phenylacetates / Q000378:metabolism*; D011124:Polyporaceae / Q000378:metabolism
D002934:Cinnamates; D010648:Phenylacetates