Change of paraprotein from IgG lambda to lambda chain in myeloma.
We describe a unique case of IgG lambda myeloma in which a plasma cell leukemia developed and the paraprotein changed from IgG lambda to lambda chain, the latter inducing fatal renal failure. In addition, J-chain was detected in the cytoplasm of the plasma cell leukemia cells.
Sawamura
M
M
Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
Murayama
K
K
Tokizawa
S
S
Matsushima
T
T
Tamura
J
J
Murakami
H
H
Naruse
T
T
Tsuchiya
J
J
D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D007144:Immunoglobulin J-Chains / Q000378:metabolism*; D007146:Immunoglobulin lambda-Chains / Q000097:blood / Q000378:metabolism*; D007952:Leukemia, Plasma Cell / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000378:metabolism*
D007074:Immunoglobulin G; D007144:Immunoglobulin J-Chains; D007146:Immunoglobulin lambda-Chains