[Suppression of macrophage subpopulations in post-traumatic osteomyelitis].
Similar to other chronic inflammatory diseases such as rheumatoid arthritis the distribution of macrophage subtypes seems to be disturbed in post-traumatic osteomyelitis. This atypical distribution is clearly locally restricted in osteomyelitis. 27E10-positive macrophages found only during the acute phase of inflammation were reduced in 39%, the 25F9-positive subtype, predominating in the late stage of inflammation, was missing in 33%. The antiinflammatory macrophage RM3/1 was decreased in 40% of the osteomyelitis biopsies. Local suppression of macrophage subsets has to be discussed as one of the reasons for the persistence of chronic inflammatory processes in osteomyelitis.
Peters
K M
KM
Orthopädische Klinik, RWTH Aachen.
Zwadlo-Klarwasser
G
G
Koberg
K
K
Rosendahl
T
T
Zilkens
K W
KW
Schmutzler
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000473:pathology*
Verminderung von Makrophagensubpopulationen bei der posttraumatischen Osteomyelitis.