Screening for thyroid disorders in a working population.
Subclinical thyroid disorders have received increasing attention in recent years due to refined laboratory methods and a stronger emphasis on the role of preventive medicine. We performed a screening for thyroid-stimulating hormone (TSH) on 6884 persons in a working population. In cases in which TSH was not within the normal range we also measured the levels of triiodothyronine (T3), thyroxine (T4), and thyroxine-binding globulin (TBG). All persons who did not present with exclusion criteria or other nonthyroidal illnesses (n = 59) and the controls (n = 39) were submitted to thyrotropin-releasing hormone (TRH)-testing. Additionally, sonography of the thyroid was performed on 120 persons (59 subjects with abnormal hormone levels and 61 controls) to determine thyroid size and rule out morphological abnormalities. Based on the TRH test and T3, T4, and TBG measurements we found a prevalence of 0.03% (2/6884) for overt hyperthyroidism, 0.33% (23/6884) for subclinical hypothyroidism, 0.09% (6/6884) for subclinical hypothyroidism, and 0.015% (1/6884) for overt hypothyroidism in the healthy population. In subjects with overt or subclinical hyperthyroidism the prevalence of goiters (thyroid volume > 18 ml in women, > 25 ml in men) was 28%. Of this group 48% had structural abnormalities. All persons with goiters and/or structural abnormalities were over 35 years of age. Among the euthyroid, 20% had thyroid enlargement, and the same proportion presented with structural abnormalities. There were no differences between the two age groups. In the group with overt/subclinical hypothyroidism 47% presented with structural abnormalities of the thyroid; however, none presented with thyroid enlargement. Thyroid nodules were found only in older persons (> 35 years) with euthyroidism or hypothyroidism.(ABSTRACT TRUNCATED AT 250 WORDS)
Schaaf
L
L
Zentrum der Inneren Medizin, Abteilung für Endokrinologie, Johann-Wolfgang Goethe Universität Frankfurt/Main.
Pohl
T
T
Schmidt
R
R
Vardali
I
I
Teuber
J
J
Schlote-Sauter
B
B
Nowotny
B
B
Schiebeler
H
H
Zober
A
A
Usadel
K H
KH
D000328:Adult; D016477:Artifacts; D005260:Female; D005858:Germany / Q000453:epidemiology; D006042:Goiter / Q000453:epidemiology; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology; D007037:Hypothyroidism / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008487:Medical History Taking; D008875:Middle Aged; D015995:Prevalence; D013959:Thyroid Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000517:prevention & control; D013963:Thyroid Hormones / Q000097:blood; D016606:Thyroid Nodule / Q000453:epidemiology; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014463:Ultrasonography
D013963:Thyroid Hormones; D013975:Thyroxine-Binding Proteins; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin