Three novel polyether antibiotics X-14889A, C, and D from a streptomycete. Taxonomy of the producing organism, fermentation production and biological properties of the antibiotics.
Antibiotic X-14889A, C, and D are novel polyether antibiotics related to lysocellin and antibiotic X-14873A. They are produced by a streptomycete isolated from a soil of Wisconsin. The antibiotic X-14889C is active against Gram-positive bacteria and exhibits ionophore property.
Liu
C M
CM
Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110.
Westley
J W
JW
Chu
J
J
Hermann
T E
TE
Liu
M
M
Palleroni
N
N
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D005663:Furans / Q000378:metabolism / Q000494:pharmacology; D007476:Ionophores / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005663:Furans; D007476:Ionophores; C080563:X 14889D; C080562:X 14889C; C080561:X 14889A