title: Atrial natriuretic factor and changes in the aldosterone response to angiotensin II in sodium depleted dogs.
abstract: The effects of physiological shifts in plasma atrial natriuretic factor (ANF) concentrations on angiotensin II/aldosterone relationships during changes in sodium status were assessed in 6 conscious beagle dogs. Incremental infusions of angiotensin II (3, 9 and 27ng/kg/min) were administered on three occasions. The animals were studied in sodium replete and deplete states and on a third occasion, again while sodium deplete, with a background constant low-dose infusion of ANF (1.5pmol/kg/min) sufficient to enhance the low endogenous plasma ANF values observed in sodium depletion to match those observed in the sodium replete state. Sodium depletion caused a leftward shift and steepened the slope of the relationship between achieved arterial angiotensin II concentrations and the plasma aldosterone response. This effect was significantly attenuated (approximately 50%) by the low dose ANF infusions which tended to flatten the slope of the angiotensin II/aldosterone curve (ns) and shifted it significantly to the right (p < 0.05). These data suggest subtle shifts in endogenous levels of plasma ANF, accompanying changes in sodium status, are a major contributor to the associated alterations in angiotensin II/aldosterone relationships. Low dose ANF also significantly reduced the effect of angiotensin II on arterial pressures but did not alter natriuresis.
authors: MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
authors: A M
authors: AM
authors: Richards
authors: M
authors: M
authors: Tree
authors: G
authors: G
authors: Tonolo
authors: P
authors: P
authors: Montorsi
authors: J
authors: J
authors: Polonia
authors: J J
authors: JJ
authors: Morton
authors: R
authors: R
authors: Fraser
authors: C
authors: C
authors: Frampton
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D009318:Natriuresis / Q000187:drug effects / Q000502:physiology; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin