Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.
Ghosh
A K
AK
Department of Medicinal Chemistry, Molecular Biology, and Virus and Cell Biology, Merck Research Laboratories, West Point, Pennsylvania 19486.
Thompson
W J
WJ
Lee
H Y
HY
McKee
S P
SP
Munson
P M
PM
Duong
T T
TT
Darke
P L
PL
Zugay
J A
JA
Emini
E A
EA
Schleif
W A
WA
D001665:Binding Sites; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D017320:HIV Protease Inhibitors; D006571:Heterocyclic Compounds; D008024:Ligands; D013450:Sulfones