Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs.
Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally 'brown', and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path--from 'brown' to 'white'.
Trayhurn
P
P
Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, Scotland, UK.
Thomas
M E
ME
Duncan
J S
JS
Nicol
F
F
Arthur
J R
JR
D000273:Adipose Tissue / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D002352:Carrier Proteins / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000378:metabolism*; D007473:Ion Channels; D008565:Membrane Proteins / Q000378:metabolism*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D012756:Sheep; D014475:Uncoupling Agents / Q000378:metabolism*; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D009838:Oligodeoxyribonucleotides; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1; D007453:Iodide Peroxidase