title: [Is it possible to obtain a reduction of body weight exclusively via a loss in fat mass? Experience with d-fenfluramine].
abstract: Aim of the study was to observe if the administration of an anorectic drug, d-fenfluramine, in addition to hypocaloric diet, could influence the body composition and adipose mass distribution during a weight decrease programme in 17 obese women. Drug's effects plus diet on body weight changes were compared with those of a "only-diet programme" in another group of 18 obese subjects, sex and age matched. Both groups were observed for a 6-month period. All subjects were selected on the base of Index Body Weight % within 120-200 and without any therapy for other diseases. Blood samples were drawn before, during (3rd month) and after the period of observation for the measurement of OGTT, serum lipids, liver and kidney function parameters, blood cells count. Body weight and height, body composition, waist-to-hip ratio were also evaluated. Results documented: 1) significant reduction of body weight in the group kept on the combined therapy; 2) significant variation of body composition with increment of fat free mass and adipose mass decrease; 3) significant improvement of glucose tolerance, liver and kidney function parameters. In conclusion, our data show beneficial effects of d-fenfluramine on appetite reduction, influencing the carbohydrates assumption and the consequent fat mass loss with a good tolerability of the drug.
authors: Istituto di Medicina Interna, Università, Chieti.
authors: A
authors: A
authors: Del Ponte
authors: N
authors: N
authors: D'Orazio
authors: G
authors: G
authors: Di Giacomo
authors: T
authors: T
authors: Tritella
authors: G
authors: G
authors: Bitti
authors: G
authors: G
authors: Martines
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000328:Adult; D000886:Anthropometry; D001823:Body Composition / Q000187:drug effects; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D005277:Fenfluramine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D005277:Fenfluramine
vernacular_title: E possibile ottenere la riduzione del peso corporeo esclusivamente attraverso una perdita di massa adiposa? Esperienze con d-fenfluramina.