The effects of chronic administration of captopril on the mouse subfornical organ and area postrema.
We have studied by morphometric procedures the chronic effect of captopril on the subfornical organ (SFO) and area postrema (AP) of the adult mouse. Oral administration of captopril does not produce any change in the size of individual nuclei of the ependymocytes and neurons in both centers. However, there are other quantitative effects of captopril on the global volume of the SFO and on the neuropil and vascular elements of both the SFO and AP which present a significant increase. It is suggested that this increase is due to metabolic processes at the level of both circumventricular organs.
Castañeyra-Perdomo
A
A
Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, Tenerife, Spain.
Meyer
G
G
Carmona-Calero
E
E
Perez-Gonzalez
H
H
Perez-Delgado
M M
MM
Bañuelos-Pineda
J
J
Ferres-Torres
R
R
D000284:Administration, Oral; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D002467:Cell Nucleus / Q000648:ultrastructure; D002552:Cerebral Ventricles / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D009415:Nerve Net / Q000648:ultrastructure; D013356:Subfornical Organ / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors
D002216:Captopril