Secretion of IL-2, IL-4, and IFN-gamma for dust mite antigens in a patient with atopic dermatitis.
In a 21-year-old female with severe atopic dermatitis, the secretion of interleukin-2 (IL-2), interleukin-4 (IL-4), and interferon-gamma (IFN-gamma) by her peripheral blood mononuclear cells (PBMC) was measured after incubation with/without antigens extracted from Dermatophagoides pteronyssinus (Dp), to which the patient had developed a positive patch-test reaction. Incubation with Dp antigen produced marked secretion of IL-2 and IFN-gamma, but not IL-4. This may suggest that Dp-specific T lymphocytes present in the circulating blood cells are capable of producing IL-2 and IFN-gamma, which may be relevant to the delayed-type allergic reaction occurring in the skin lesion.
Kubota
Y
Y
Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Koga
T
T
Imayama
S
S
Hori
Y
Y
D000328:Adult; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D039741:Antigens, Dermatophagoides; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000378:metabolism*; D007376:Interleukin-2 / Q000097:blood / Q000378:metabolism*; D015847:Interleukin-4 / Q000097:blood / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008925:Mites; D010328:Patch Tests; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D000941:Antigens; D039741:Antigens, Dermatophagoides; D007376:Interleukin-2; D015847:Interleukin-4; D007371:Interferon-gamma