A review of the toxicology of the antibiotic MICOTIL 300.
MICOTIL 300 is a new macrolide antibiotic for the treatment of Bovine Respiratory Disease complex. As with other macrolides used in human and veterinary medicine, overdoses of MICOTIL do not produce pathognomonic lesions. The toxicity dose response varies among laboratory animal and domestic livestock species. However, clinical evidence of MICOTIL toxicity due to large doses is generally a manifestation of the positive chronotropic and negative inotropic cardiovascular effects. No adverse environmental effects are expected from the use of MICOTIL in cattle.
Jordan
W H
WH
Lilly Research Laboratories, Greenfield, Indiana 46140.
Byrd
R A
RA
Cochrane
R L
RL
Hanasono
G K
GK
Hoyt
J A
JA
Main
B W
BW
Meyerhoff
R D
RD
Sarazan
R D
RD
D000818:Animals; D000900:Anti-Bacterial Agents; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D004350:Drug Residues; D018942:Macrolides; D016978:Mannheimia haemolytica; D010326:Pasteurella Infections / Q000188:drug therapy / Q000662:veterinary; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000662:veterinary; D013997:Time Factors; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity
D000900:Anti-Bacterial Agents; D018942:Macrolides; C052319:tilmicosin; D015645:Tylosin