Immunohistochemical staining for CA-125 in fallopian tube carcinomas.
From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.
Puls
L E
LE
Department of Obstetrics and Gynecology, University of Kentucky Medical Center, Lexington 40536.
Davey
D D
DD
DePriest
P D
PD
Gallion
H H
HH
van Nagell
J R
JR
Hunter
J E
JE
Pavlik
E J
EJ
D000230:Adenocarcinoma / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis* / Q000097:blood; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging
D015295:Antigens, Tumor-Associated, Carbohydrate