Effect of a high-carbohydrate diet intake on muscle glycogen repletion after exercise in rats previously fed a high-fat diet.
The effect of a high-carbohydrate (C) diet intake on muscle glycogen repletion during the early period of recovery from exercise was studied in rats previously fed a high-fat (F) diet. In experiment 1, 3 week-old male and in experiment 2, 3 week-old female rats were used. Rats were fed either the F or the C diet for 2-10 weeks ad libitum and then were meal-fed regularly twice a day for 25 days in experiment 1, or for 5 weeks in experiment 2. During the period of regular feeding, half of the rats in both dietary groups continued to eat as before (F-F and C-C) but the other half of the rats were switched to the counterpart diets (F-C and C-F) in experiment 1. In experiment 2, half of the F-F group were switched to the C diet (F-C) for 3, 7, and 14 days after the period of regular feeding. Pre-exercise glycogen content in soleus, red gastrocnemius, and heart muscles and liver was higher in rats fed the C diet (C-C and F-C) than in rats fed the F diet (F-F and C-F) in experiment 1. Glycogen repletion in red muscle 2 h after the ingestion of a glucose and citrate (3.0 and 0.5 g, respectively, per kg body mass) drink was also higher in the former than in the latter. There was a positive relationship in skeletal muscles between pre-exercise glycogen content and the rate of glycogen repletion.(ABSTRACT TRUNCATED AT 250 WORDS)
Saitoh
S
S
Laboratory of Biochemistry of Exercise and Nutrition, University of Tsukuba, Ibaraki, Japan.
Shimomura
Y
Y
Suzuki
M
M
D020155:3-Hydroxybutyric Acid; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D006006:Glycogen Synthase / Q000378:metabolism; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000201:enzymology / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007328:Insulin; D008112:Liver Glycogen; D006003:Glycogen; D006006:Glycogen Synthase; D020155:3-Hydroxybutyric Acid