Bacterial-induced activation of erythrocyte T-antigen complicating necrotising enterocolitis: a case report.
Erythrocyte Thomsen-Friedenreich crypt antigen (T-antigen) activation is not an uncommon event in infants with severe necrotising enterocolitis (NEC). Transfusion of these infants with blood products containing plasma carries the risk of causing intravascular haemolysis. T-antigen activation is easily detected using a rapid simple lectin agglutination test. Early recognition of T-antigen activation ensures the correct choice of plasma free transfusion therapy. We describe an infant with severe NEC complicated by T-antigen activation and haemolysis.
Mupanemunda
R H
RH
Department of Paediatrics, University of Western Ontario, London, Canada.
Kenyon
C F
CF
Inwood
M J
MJ
Leigh
K
K
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology*; D003016:Clostridium perfringens; D004761:Enterocolitis, Pseudomembranous / Q000276:immunology*; D006461:Hemolysis; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male
D015295:Antigens, Tumor-Associated, Carbohydrate; C016467:Thomsen-Friedenreich antigen