[Myelodysplastic syndrome associated with clonal proliferation of B lymphocytes].
We present an unusual case of the myelodysplastic syndrome (subtype refractory anemia with the excess of blasts in transformation--RAEB-t) associated with significant increase of IgG (4,700 mg/dl), lambda (160 U/dl) in blood serum and circulating clone of B lymphocytes SIgG, lambda, manifesting clonal rearrangement of JH domain. Peripheral blood cells of the patient showed two different chromosomal abnormalities: 47,XY, + del/8/p? and 47,XY, +22, +14, -19. We suppose that two independent neoplastic clones are developed in the described case, i.e. a population displaying markers of myeloblasts and monoblasts, and a clone of B lymphocytes.
Rupniewska
Z M
ZM
Kliniki Hematologii A.M., Lublinie.
Roliński
J
J
Siedlecki
J A
JA
Kulik
J
J
Bieganowski
P
P
Pieńkowska
B
B
Rygier
J
J
Rozynkowa
D
D
Wach
M
M
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002999:Clone Cells; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007621:Karyotyping; D008213:Lymphocyte Activation; D008297:Male
D007074:Immunoglobulin G
Zespół mielodysplastyczny przebiegajacy z klonalna proliferacja limfocytów B.