title: Serum placental protein 14 concentrations in the first trimester of ovum donation pregnancies.
abstract: The concentration of the endometrial glycoprotein placental protein 14 (PP14) has been measured at weekly intervals during the first trimester in serum obtained from women who had become pregnant naturally (n = 15, all singleton) or following ovum donation (n = 16, 15 singleton and one twin) after ovarian failure (n = 13), Turner's syndrome (n = 2) or post-chemotherapy (n = 1). The concentration of PP14 failed to rise in ovum donation pregnancies, and was significantly reduced compared to the concentration in natural conceptions from 5 to 13 weeks gestation (P < 0.05-0.01). These findings demonstrate that the corpus luteum is essential for the normal increase in serum PP14 in the first trimester. Furthermore, they suggest that progesterone is not the major stimulus to PP14 synthesis in early pregnancy.
authors: Department of Obstetrics and Gynaecology, Royal London Hospital, Whitechapel, UK.
authors: M R
authors: MR
authors: Johnson
authors: A
authors: A
authors: Brooks
authors: J Q
authors: JQ
authors: Norman-Taylor
authors: J G
authors: JG
authors: Grudzinskas
authors: M E
authors: ME
authors: Wren
authors: P
authors: P
authors: Murugni
authors: T
authors: T
authors: Chard
authors: H
authors: H
authors: Abdalla
mesh_terms: D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D010063:Ovum; D011247:Pregnancy / Q000097:blood*; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First; D014019:Tissue Donors
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins