title: Primary parathyroid gland hyperplasia in dogs: six cases (1982-1991).
abstract: Persistent hypercalcemia attributable to parathyroid gland hyperplasia was identified in 6 dogs with primary hyperparathyroidism. Clinical signs included polydipsia (n = 4), polyuria (n = 4), and signs caused by cystic calculi (n = 3). Abnormal clinical pathologic findings included hypercalcemia (mean, 13.6 mg/dl; range, 12.6 to 14.7 mg/dl; n = 6), hypophosphatemia (mean, 2.2 mg/dl; range, 1.4 to 2.9 mg/dl; n = 6), high serum alkaline phosphatase activity (mean, 222 IU/L; range, 161 to 286 IU/L; n = 3), and isosthenuria (mean, 1.012; range, 1.006 to 1.017; n = 6). Serum parathyroid hormone concentration was within the reference range or high (mean, 23 pmol/L; range, 7 to 119 pmol/L; reference range, 1.5 to 13 pmol/L) in all dogs. At surgery, the number of large parathyroid glands was variable, being limited to 1 gland in 3 dogs, 2 glands in 2 dogs, and 4 glands in 1 dog. All visibly large parathyroid glands were surgically removed from each dog. Serum calcium concentration decreased into or below the reference range within 72 hours of surgery in all dogs, confirming the diagnosis of primary parathyroid disease. Multiple nodules of adenomatous hyperplasia were identified in each dog. All 6 dogs were treated with vitamin D and calcium carbonate following surgery. The dog from which all 4 parathyroid glands were removed has remained eucalcemic for more than 1 year with vitamin D supplementation. Vitamin D and calcium administration was discontinued within 4 to 12 weeks of surgery in the remaining 5 dogs. These dogs remained eucalcemic without vitamin D supplementation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616.
authors: S E
authors: SE
authors: DeVries
authors: E C
authors: EC
authors: Feldman
authors: R W
authors: RW
authors: Nelson
authors: P C
authors: PC
authors: Kennedy
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D004283:Dog Diseases / Q000209:etiology* / Q000601:surgery; D004285:Dogs; D005260:Female; D006934:Hypercalcemia / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D006961:Hyperparathyroidism / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D006965:Hyperplasia; D008297:Male; D010280:Parathyroid Glands / Q000473:pathology* / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011141:Polyuria / Q000662:veterinary; D012189:Retrospective Studies; D013577:Syndrome; D013894:Thirst; D001744:Urinary Bladder Calculi / Q000209:etiology / Q000662:veterinary; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D000469:Alkaline Phosphatase; D002118:Calcium