Different effects of CCK antagonists on gastric-acid response to CCK and pentagastrin.
The role of CCK receptor subtypes in peptide-stimulated acid secretion was assessed in six unanesthetized rats. The CCK-stimulated acid secretion was not blocked by L-365,260, a CCKB/gastrin receptor antagonist, and was significantly increased by devazepide, a CCKA receptor antagonist, given alone or together with L-365,260. L-365,260, but not devazepide, blocked pentagastrin-stimulated acid secretion, and, when given together, devazepide abolished the effect of L-365,260. We conclude: 1) pentagastrin stimulates acid secretion through a gastrin-type receptor, but CCK may not, and 2) pentagastrin and CCK can stimulate acid secretion despite simultaneous blockade of CCKB/gastrin and CCKA receptors.
Corwin
R L
RL
Department of Psychiatry, Cornell University Medical College, NY.
Smith
G P
GP
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D020109:Devazepide; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D010671:Phenylurea Compounds; D051381:Rats; D017207:Rats, Sprague-Dawley; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000145:classification / Q000502:physiology
D001570:Benzodiazepinones; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260; D002766:Cholecystokinin; D010418:Pentagastrin; D020109:Devazepide