The effect of halothane dose on striatal dopamine: an in vivo microdialysis study.
The relationship between a level of an anesthesia state and striatal dopamine concentration was investigated. The effect of halothane administration on dopamine level in rat striatal extracellular fluid was determined in tracheotomized rats, using an in vivo brain microdialysis method. The striatal dopamine was increased by halothane doses. The correlation coefficient between halothane and dopamine concentrations was 0.69.
Miyano
K
K
Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
Tanifuji
Y
Y
Eger
E I
EI
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D008846:Micromanipulation; D051381:Rats; D017207:Rats, Sprague-Dawley
D015102:3,4-Dihydroxyphenylacetic Acid; D006221:Halothane; D004298:Dopamine; D006719:Homovanillic Acid