title: Fibroblast growth factor influences the development and cycling of murine hair follicles.
abstract: The effects of basic fibroblast growth factor (bFGF) on the development of hair follicles in neonatal mouse skin were examined. Newborn mice (B6C3-based strain) were given daily subcutaneous injections of bFGF and bovine serum albumin (BSA) for 7 days. By Day 9, distinct areas of hairless, unpigmented skin were observed surrounding the sites treated with bFGF. This phenomenon persisted until about 14-16 days of age when the emergence of hair in the bald patches was first seen. Hair growth continued in the treated regions until they were mostly covered at 18-20 days of postnatal age. Control sites injected with BSA only were indistinguishable from the surrounding pigmented, hairy skin at all ages. Histological examination of skin from various ages of bFGF-treated mice suggested that the growth factor had affected both the initiation and the development of the hair follicles. This resulted in a significant delay in the first and subsequent hair cycles when compared to control animals injected with BSA only.
authors: Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195.
authors: D L
authors: DL
authors: du Cros
mesh_terms: D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006197:Hair / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D008815:Mice, Inbred Strains; D009024:Morphogenesis / Q000187:drug effects; D012710:Serum Albumin, Bovine / Q000494:pharmacology
chemical_list: D016222:Fibroblast Growth Factor 2; D012710:Serum Albumin, Bovine