d-alpha-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells.
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.
Ozer
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NK
Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
Palozza
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P
Boscoboinik
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D
Azzi
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A
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002463:Cell Membrane Permeability; D006801:Humans; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000201:enzymology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D008077:Lipoproteins, LDL; D014810:Vitamin E; D011493:Protein Kinase C