title: Clues to the pathogenesis of familial colorectal cancer.
abstract: A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of sporadic colon cancers. Neither the familial nor sporadic cancers showed loss of heterozygosity for chromosome 2 markers, and the incidence of mutations in KRAS, P53, and APC was similar in the two groups of tumors. Most of the familial cancers, however, had widespread alterations in short repeated DNA sequences, suggesting that numerous replication errors had occurred during tumor development. Thirteen percent of sporadic cancers had identical abnormalities and these cancers shared biologic properties with the familial cases. These data suggest a mechanism for familial tumorigenesis different from that mediated by classic tumor suppressor genes.
authors: Department of Medical Genetics, University of Helsinki, Finland.
authors: L A
authors: LA
authors: Aaltonen
authors: P
authors: P
authors: Peltomäki
authors: F S
authors: FS
authors: Leach
authors: P
authors: P
authors: Sistonen
authors: L
authors: L
authors: Pylkkänen
authors: J P
authors: JP
authors: Mecklin
authors: H
authors: H
authors: Järvinen
authors: S M
authors: SM
authors: Powell
authors: J
authors: J
authors: Jen
authors: S R
authors: SR
authors: Hamilton
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003110:Colonic Neoplasms / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D009154:Mutation; D010375:Pedigree; D011110:Polymorphism, Genetic; D012004:Rectal Neoplasms / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers