Lectin histochemical study on the kidney of normal and streptozotocin-induced diabetic hamsters.
Lectin histochemical characteristics of the kidney of normal and streptozotocin (SZ)-induced diabetic APA hamsters were investigated. Paraffin sections of the kidney of animals killed at 1 and 3 months after SZ-injection were stained with the following 10 lectins: PNA, BPA, DBA, SBA, GSA-I, GSA-II, MPA, WGA, UEA-1 and Con A. Renal lectin binding characteristics of normal APA hamsters differed in some aspects from those in other species reported previously. In the kidney of SZ-induced diabetic APA hamsters, binding activities of some lectins increased in the affected Bowman's capsules and glomeruli as well as in degenerated epithelial cells of uriniferous tubules. Among them, GSA-II in particular exhibited strong binding activity to the degenerated epithelial cells of Bowman's capsules, distal convoluted tubules and collecting ducts.
Aguirre
J I
JI
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Han
J S
JS
Itagaki
S
S
Doi
K
K
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006651:Histocytochemistry; D007668:Kidney / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D037102:Lectins / Q000378:metabolism*; D008138:Loop of Henle / Q000378:metabolism; D008297:Male; D008647:Mesocricetus
D001786:Blood Glucose; D037102:Lectins