Immunogenetics of familial rheumatoid arthritis: a study of 41 multicase families.
HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (chi 2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.
Taneja
V
V
Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.
Mehra
N K
NK
Singh
R R
RR
Anand
C
C
Malaviya
A N
AN
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens