title: Bone tumors other than osteosarcoma after retinoblastoma.
abstract: BACKGROUND
  The most frequent second malignant neoplasm after retinoblastoma is osteosarcoma, which may be associated with radiation therapy or arise de novo in patients with bilateral retinoblastoma.
  
  
  METHODS
  Clinical, pathologic, and diagnostic imaging findings in two patients with Ewing sarcoma (ES) and one with peripheral neuroepithelioma (PN) are presented.
  
  
  RESULTS
  Second malignant neoplasms located in the extremities or pelvis were seen 12-18 years after initial diagnosis of unilateral (two patients) or bilateral (one patient) retinoblastoma. The patients with unilateral retinoblastoma were treated by enucleation only; the other received ocular radiation therapy and chemotherapy. To the knowledge of the authors, this is the first documentation of round blue cell tumor after unilateral retinoblastoma.
  
  
  CONCLUSIONS
  ES and PN should be included in the differential diagnosis of malignant neoplasms occurring after treatment of unilateral or bilateral retinoblastoma.
authors: Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
authors: K J
authors: KJ
authors: Helton
authors: B D
authors: BD
authors: Fletcher
authors: L E
authors: LE
authors: Kun
authors: J J
authors: JJ
authors: Jenkins
authors: C B
authors: CB
authors: Pratt
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis*; D003131:Combined Modality Therapy; D015353:Eye Enucleation; D005134:Eye Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis*; D012175:Retinoblastoma / Q000628:therapy*; D012512:Sarcoma, Ewing / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed