title: Bioassay from two parabolas.
abstract: The paper deals with potency ratio estimation of parallel curve analytic dilution assays in case log dose-response relationship could be reasonably described by a parabola. It comprises: (1) testing the adequacy and validity of the quadratic model by the analysis of variance; and (2) estimation of the relative potency of an unknown in relation to a standard preparation, its standard deviation and fiducial limits for its true value. The method is applicable whenever successive doses of an unknown are a constant multiple of a standard in randomized blocks or completely randomized design. The method can be generalized to polynomial models of higher order.
authors: Department of Community Medicine, Faculty of Medicine & Health Sciences, Al-Ain, United Arab Emirates.
authors: M A
authors: MA
authors: Moussa
mesh_terms: D000704:Analysis of Variance; D015982:Bias; D001681:Biological Assay / Q000592:standards*; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D016014:Linear Models; D015203:Reproducibility of Results; D012986:Software Validation; D013810:Therapeutic Equivalency