title: Osteoinductive activity of composites of bone morphogenetic protein and pure titanium.
abstract: Titanium sponges were infused with bone morphogenetic protein (BMP-Ti), and the osteoinductivity of the resultant composite was measured. New bone formation occurred three weeks after implantation and was identified by soft x-ray analysis. Quantitative analysis showed no significant difference between BMP-Ti composites and control samples (BMP only). Consequently, pure titanium neither inhibited nor promoted BMP activity. Chondrocytes and new bone formation occurred in direct contact with the surfaces of the titanium. X-ray microanalysis demonstrated new bone formation inside the pores of the titanium sponges. The BMP-Ti composite has interesting properties as an osteoinductive implant and has potential practical clinical applications.
authors: Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
authors: T
authors: T
authors: Kawai
authors: A
authors: A
authors: Mieki
authors: Y
authors: Y
authors: Ohno
authors: M
authors: M
authors: Umemura
authors: H
authors: H
authors: Kataoka
authors: S
authors: S
authors: Kurita
authors: M
authors: M
authors: Koie
authors: T
authors: T
authors: Jinde
authors: J
authors: J
authors: Hasegawa
authors: M R
authors: MR
authors: Urist
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000033:anatomy & histology / Q000378:metabolism*; D004337:Drug Carriers; D006614:Hindlimb; D051379:Mice; D011506:Proteins / Q000378:metabolism*; D014025:Titanium / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D011506:Proteins; D014025:Titanium