[The behavior of the fibrinogen polymerization curve in hypercholesterolemic subjects].
Several epidemiological and clinical studies performed in subjects with risk factors for atherosclerotic cardiovascular events, have shown changes in plasma levels and/or activities of coagulation factors that could suggest a prothrombotic state. We studied the behaviour of the fibrinogen polymerization curve (FPC), a spectrophotometric technique evaluating the kinetics of fibrinogen transformation into fibrin, in 68 subjects with and without hypercholesterolemia. Significant differences were found between FPCs of subjects with serum cholesterol > 240 mg/dl and < or = 240 mg/dl respectively. In fact, FPCs of the first group showed high reaction velocity rate, short latency time and higher optical density rate, final readings; besides, the behaviour of FPCs was not correlated to plasma fibrinogen concentrations. Therefore, FPC could be a useful test to identify a thrombophilic condition in hypercholesterolemic patients.
Alessandri
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Istituto di Terapia Medica Sistematica, Università degli Studi di Roma La Sapienza.
Bucci
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Pacillo
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Ricci
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D000328:Adult; D001161:Arteriosclerosis / Q000097:blood / Q000453:epidemiology; D005260:Female; D005337:Fibrin / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014680:Veins
D005337:Fibrin; D005340:Fibrinogen
Comportamento della curva di polimerizzazione del fibrinogeno in soggetti ipercolesterolemici.