Structural analysis of an extremely long 5'-noncoding region of rat brain argininosuccinate lyase mRNA: presence of multiple B1 repeats and multiple upstream AUG codons, and a possibility of translational control.
The present detailed analysis of the sequence of the extremely long (967 bp) 5'-noncoding region of a rat brain argininosuccinate lyase cDNA clone, reveals several features of interest. Multiple copies of partial and inverted (antisense) B1 repeats and multiple upstream ATG codons are present in the region, which suggests a possibility of translational control of the argininosuccinate lyase gene expression in rat brain.
Kawamoto
S
S
Department of Bacteriology, Yokohama City University School of Medicine, Japan.
Amaya
Y
Y
Hattori
S
S
Miyagi
Y
Y
Onishi
H
H
Okuda
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001123:Argininosuccinate Lyase / Q000235:genetics*; D001483:Base Sequence; D001921:Brain / Q000201:enzymology*; D003062:Codon; D008969:Molecular Sequence Data; D005810:Multigene Family; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats
D003062:Codon; D012333:RNA, Messenger; D001123:Argininosuccinate Lyase