[The significance of arterial redox potential measurement by Vincent's method in evaluating the hemorrhagic shock state of rabbits].
Previously we suggested that the arterial redox potential (ARp) is one of the most reliable indicators to evaluate the severity and outcome of the acutely-ill patients. In this study we attempted to clarify which redox system, intracellular or extracellular, is mainly represented by redox potentials measured from arterial blood in the hemorrhagic shock state rabbits. The arterial pyruvate/lactate, acetoacetate/beta-hydroxybutyrate and oxidized glutathione/reduced glutathione (GSSG/GSH) ratios were measured in hemorrhagic shock rabbits, and correlations between ARp and each of these factors were analyzed. The best correlation was found between ARp and P/L ratio. This indicates that ARp well reflects the cytosolic redox state, i.e. cytosolic [NAD+]/[NADH], and also [ATP]/[ADP][Pi] theoretically. The ARp is a valuable index in evaluating the shock state and can be easily measured with Vincent's method.
Taniguchi
S
S
Department of Surgical Operation Theater, Faculty of Medicine, Kyushu University, Fukuoka.
D000818:Animals; D010084:Oxidation-Reduction; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000097:blood*