Fluoroscopically guided incision of ureteral strictures in pigs with the cautery-wire balloon catheter: a phase 1 study.
We investigated a catheter that can longitudinally incise ureteral strictures under fluoroscopic guidance without the need for ureteroscopy and its attendant risks. The catheter consists of a low-pressure balloon and an overlying cautery wire; the balloon allows precise localization of the stricture, seen as a waist in the balloon, and the overlying cautery wire can be fluoroscopically oriented at the stricture. One to two centimeter ureteral strictures were created in 6 swine. Two to four weeks later strictures were incised in a retrograde or antegrade fashion with the cautery-wire balloon catheter, and double J stents placed for a duration of three weeks. In 5 of 6 renal units strictures improved anatomically with resolution of hydronephrosis at 3 to 4 months' follow-up. Urodynamic absence of obstruction was verified by Whitaker testing. In one animal, the tip of the catheter dislodged in the ureter with subsequent loss of the renal unit. The engineering error that lead to this complication has since been rectified. With correction of the aforementioned problem, this Phase 1 study has demonstrated the feasibility, safety and preliminary efficacy of the cautery-wire balloon catheter for endourologic management of ureteral strictures.
Aronson
W J
WJ
Division of Urology, UCLA Medical Center 90024.
Barbaric
Z L
ZL
Fain
J S
JS
Fuchs
G J
GJ
D000818:Animals; D002404:Catheterization; D005260:Female; D005471:Fluoroscopy; D013552:Swine; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging / Q000601:surgery*