Effects of hepatic vagotomy on suppression of water intake induced by hepatic portal infusion of water in water-deprived rats.
We investigated the effects of hepatic vagotomy on the suppression of water intake induced by hepatic portal infusion of water by 24-h water-deprived rats. In sham-operated rats, water intake of the portal infusion group was significantly less than that of the jugular infusion group during and after the infusion of deionized water for 3.5 h at a rate of 52 microliters/min. This result reconfirmed our previous findings. On the other hand, in hepatic-vagotomized rats, the suppression during the portal infusion of water was not observed, but the suppression after portal infusion was observed. It is concluded that the suppression, at least during the portal infusion of water, was mediated by hepatoportal osmo-receptive (or sodium-receptive) afferent signals contained in the hepatic branch of the vagus nerve.
Kobashi
M
M
Department of Physiology, Okayama University Dental School, Japan.
Adachi
A
A
D000818:Animals; D004327:Drinking Behavior; D007262:Infusions, Intravenous; D008099:Liver / Q000294:innervation*; D008297:Male; D011168:Portal System / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013997:Time Factors; D014628:Vagotomy; D014867:Water / Q000008:administration & dosage; D014868:Water Deprivation
D014867:Water