title: Effects of gastrin-releasing peptide and analogues on guinea pig nasal mucosal secretion.
abstract: The effects of gastrin-releasing peptide (GRP), bombesin, GRP-(1-16) and GRP-(21-27) on guinea pig nasal mucosal secretion were studied in vivo. GRP, bombesin, and GRP-(21-27) induced significant secretion of total protein, albumin, and alkaline phosphatase. GRP induced significant secretion at lower concentrations (10(-11) and 10(-10) M) than were required for bombesin and GRP-(21-27) (10(-7) M). GRP-(1-16) did not stimulate secretion, indicating that the COOH-terminal region of GRP contained the secretagogic principle. Capsaicin, a stimulant of nociceptive sensory nerves, stimulated GRP release into nasal secretions. These data suggest that GRP is present in guinea pig nasal mucosa and that the COOH-terminal region of GRP may regulate mucosal macromolecule secretion.
authors: Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
authors: A Z
authors: AZ
authors: Gawin
authors: J N
authors: JN
authors: Baraniuk
authors: J D
authors: JD
authors: Lundgren
authors: M
authors: M
authors: Kaliner
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019886:Gastrin-Releasing Peptide; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
chemical_list: D005768:Gastrointestinal Hormones; D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D011506:Proteins; C080749:gastrin releasing peptide (1-16); C080748:gastrin releasing peptide (21-27); D019886:Gastrin-Releasing Peptide; D001839:Bombesin