Pharmacokinetics of 14C-N-N'-dicyclopropyl-methyl-piperazine-dichlorhydrate. 1st Communication: balance of elimination, plasma and blood kinetics, metabolism in rats.
N-N'-Dicyclopropyl-methyl-piperazine-dichlorhydrate (Ino 2628-CZ) is a novel inotropic compound. The absorption, distribution, excretion and metabolism of radiochemically labelled 14C-Ino 2628-CZ has been studied in male and female rats after intravenous and oral administration. The compound was mainly excreted during the first 24 h after both administrations, although traces of radioactivity were still measured at 7 days post-dose. About 20% of the drug is excreted in the urine unchanged. Nine metabolites were separated, four of them being characterized.
Tufenkji
A E
AE
Laboratoire de Pharmacologie-Pharmacocinétique, Faculté des Sciences Pharmaceutiques, Toulouse, France.
Campistron
G
G
Malbosc
R
R
Declume
C
C
Dormard
Y
Y
Atabakhsh
F
F
Benard
P
P
Houin
G
G
D000284:Administration, Oral; D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005243:Feces / Q000737:chemistry; D005260:Female; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002316:Cardiotonic Agents; D010879:Piperazines; C059182:N,N'-dicyclopropylmethylpiperazine