Increased specificity of antibody detection in surgical patients with invasive candidiasis with cytoplasmic antigens depleted of mannan residues.
In this study, it was shown that the diagnostic accuracy of antibody detection by a counterimmunoelectrophoresis technique could be improved by using cytoplasmic antigens depleted of mannan residues. The specificity of the counterimmunoelectrophoresis increased from 28.6 to 78.6% when cytoplasmic antigens depleted of mannan were used, while the sensitivity slightly decreased from 80 to 70%.
van Deventer
A J
AJ
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands.
van Vliet
H J
HJ
Voogd
L
L
Hop
W C
WC
Goessens
W H
WH
D000908:Antibodies, Fungal / Q000097:blood*; D000946:Antigens, Fungal / Q000737:chemistry / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis*; D003378:Counterimmunoelectrophoresis; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D008351:Mannans / Q000276:immunology; D012680:Sensitivity and Specificity
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D008351:Mannans