Vav: a potential link between tyrosine kinases and ras-like GTPases in hematopoietic cell signaling.
The vav proto-oncogene encodes a 95 kDa protein which is expressed exclusively in hematopoietic cells. Analysis of the deduced amino acid sequence has revealed the presence of a src-homology 2 (SH2) domain, 2 SH3 domains, a cysteine-rich region with similarity to protein kinase C, and a region highly similar to proteins with guanine nucleotide exchange activity on ras-like GTPases. Recent work has shown that vav is tyrosine phosphorylated in response to stimulation of surface membrane receptors in a variety of hematopoietic cell lines. Vav may play a role in hematopoietic cell signaling by coupling tyrosine kinase pathways to ras-like GTPases through the regulation of guanine nucleotide exchange.
Hu
P
P
Department of Pharmacology, NYU Medical Center, New York 10016.
Margolis
B
B
Schlessinger
J
J
D000818:Animals; D018797:Cell Cycle Proteins; D020558:GTP Phosphohydrolases / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051567:Proto-Oncogene Proteins c-vav; D016283:Proto-Oncogene Proteins p21(ras); D015398:Signal Transduction
D018797:Cell Cycle Proteins; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D011505:Protein-Tyrosine Kinases; D020558:GTP Phosphohydrolases; D016283:Proto-Oncogene Proteins p21(ras)