title: Female genito-urethroplasty and submucosal periurethral collagen injection as adjunctive procedures for continence in the exstrophy-epispadias complex. Preliminary results.
abstract: Continence is the main goal in the treatment of patients with bladder exstrophy and prognosis is necessarily long-term. Over an 8-year period, 44 patients presented with bladder exstrophy and/or incontinent epispadias. Twenty-five bladder closures (7 secondary), 23 male urethroplasties, 19 bladder neck (BN) reconstructions and 6 bladder augmentations were performed in these patients. In 18 children 2 additional procedures were employed in the last 3 years: female genito-urethroplasty (15) and submucosal periurethral collagen injection (11). Eight children underwent both procedures. Genito-urethroplasty and collagen injection were performed before BN reconstruction in 6 and 5 cases respectively, in order to increase bladder outlet resistance. The submucosal injection was performed at 3, 9 and 12 o'clock in the BN or sphincteric urethra, using 0.75 to 2.5 ml of cross-linked bovine collagen. Continence in the children who underwent the complete staged reconstruction was good in 58%, fair in 32% and poor in 11%. Following female genito-urethroplasty and periurethral collagen injection, bladder capacities increased by 25%. These complementary procedures are effective in increasing outlet resistance and bladder capacity in patients with exstrophy and/or epispadias; they may improve continence and lessen the need for further bladder augmentation.
authors: Department of Paediatric Surgery, Bambino Gesú Children's Hospital, Rome, Italy.
authors: P
authors: P
authors: Caione
authors: N
authors: N
authors: Capozza
authors: A
authors: A
authors: Lais
authors: G
authors: G
authors: Creti
authors: M
authors: M
authors: De Gennaro
mesh_terms: D001746:Bladder Exstrophy / Q000601:surgery / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004842:Epispadias / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D014521:Urethra / Q000601:surgery*
chemical_list: D003094:Collagen