Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.
UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.
van Es
H H
HH
Department of Medicine, McGill University, Montréal, Québec, Canada.
Bout
A
A
Liu
J
J
Anderson
L
L
Duncan
A M
AM
Bosma
P
P
Oude Elferink
R
R
Jansen
P L
PL
Chowdhury
J R
JR
Schurr
E
E
D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization
D014453:Glucuronosyltransferase