Effect of dietary T-2 toxin on biogenic monoamines in discrete areas of the rat brain.
Acute T-2 toxin treatments alter biogenic monoamine concentrations in the brain; however, these perturbations have not been well documented or demonstrated in feeding trials. In this study, the effect of dietary T-2 toxin on regional brain concentrations of biogenic monoamines and their metabolites was investigated in male rats fed a semi-synthetic diet containing 0, 2.5 or 10 ppm T-2 toxin for either 7 or 14 days. Reduction in feed consumption, feed efficiency and weight gain was observed in rats fed either 2.5 or 10 ppm T-2 toxin. This effect was transient in animals fed the 10 ppm T-2 toxin diet, with feed consumption, feed efficiency and weight gain improving significantly during wk 2. T-2 toxin affected brain biogenic monoamine concentrations. In the nucleus raphe magnus, serotonin, 5-hydroxy-3-indoleacetic acid and norepinephrine increased in a dose-dependent manner, and dopamine increased transiently. In the substantia nigra of rats fed 10 ppm T-2, epinephrine increased after 7 days and norepinephrine decreased after 14 days, when compared with controls. Dihydroxyphenylacetic acid concentrations in the paraventricular nucleus and medial forebrain bundle were lower in T-2 toxin-treated rats than in control animals. The observed effects of T-2 toxin on brain monoamines and the resulting neurochemical imbalance may account for the physiological manifestation of trichothecene intoxication.
Wang
J
J
Department of Food and Nutrition, University of Manitoba, Winnipeg, Canada.
Fitzpatrick
D W
DW
Wilson
J R
JR
D000284:Administration, Oral; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004032:Diet; D004435:Eating / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013605:T-2 Toxin / Q000008:administration & dosage / Q000633:toxicity*
D015306:Biogenic Monoamines; D013605:T-2 Toxin