title: [Longitudinal study of bronchial hyperreactivity using the carbachol test with school children].
abstract: METHODS
  Bronchial hyperresponsiveness of 476 schoolchildren (10.8 +/- 2.3 years) was studied three times at 12 months' intervals. The cumulative dose of 400 micrograms carbachol was applied in 50 + 50 + 100 + 200 micrograms steps. A fall of FEV1 of at least 15% was regarded as positive reaction. The test was save, as no severe obstruction was observed, only three children withdrew because of unpleasant cough.
  
  
  RESULTS
  Reactivity was observed in 19.1, 10.0, and 5.2% of children at the occasion of the first, second and third test (sensitivity/specificity for prevalence of physician diagnosed asthma: 70/83, 35/91, and 24/96%, respectively). Reactivity was age dependent (7-11 years: 35%, 12-16 years: 18%), not influenced by sex, and the relative risk to be reactive was 1.9 in children 2-3 weeks after a respiratory tract infection.
  
  
  CONCLUSIONS
  For epidemiological purposes carbachol provocation test--like other unspecific bronchial provocation tests--is inappropriate as a single test to classify individuals as asthmatics.
authors: Universitätskinderklinik Freiburg im Breisgau.
authors: J
authors: J
authors: Forster
authors: A
authors: A
authors: Hendel-Kramer
authors: K
authors: K
authors: Weis
authors: J
authors: J
authors: Kühr
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology; D016535:Bronchial Hyperreactivity / Q000175:diagnosis* / Q000453:epidemiology; D001985:Bronchial Provocation Tests / Q000379:methods*; D002217:Carbachol; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male
chemical_list: D002217:Carbachol
vernacular_title: Längsschnittuntersuchung der bronchialen Hyperreaktivität im Carbacholtest bei Schulkindern.