title: Preservation of regional and global left ventricular function by intracoronary infusion with oxygenated fluorocarbon emulsion Therox in dogs.
abstract: We tested the oxygen transport and delivery capacity of the novel perfluorocarbon emulsion, Therox (F44E, 1,2-bis-perfluorobutyl-ethylene) by comparing left ventricular regional and global function in dogs during perfusion of the left anterior descending coronary artery (LAD) with oxygenated Krebs buffer and oxygenated Therox emulsion (20% w/v) at 20 ml/min for two separate 3 min periods. During LAD perfusion with oxygenated Krebs buffer, complete loss of systolic wall thickening in the LAD perfusion area was observed, dP/dt was significantly reduced and left ventricular end-diastolic pressure (LVEDP) was increased. In contrast, LAD perfusion with oxygenated Therox maintained regional wall thickening at 60-70% of control and completely preserved global function as measured by dP/dt and LVEDP. Thus, Therox is an effective oxygen carrier in this animal model.
authors: Du Pont Merck Pharmaceutical Company, Wilmington, DE 19898.
authors: M J
authors: MJ
authors: Thoolen
authors: D E
authors: DE
authors: Rasbach
authors: J H
authors: JH
authors: Shaw
authors: S
authors: S
authors: Raynolds
authors: P B
authors: PB
authors: Timmermans
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002021:Buffers; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D017202:Myocardial Ischemia / Q000517:prevention & control*; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D002021:Buffers; D005466:Fluorocarbons; C057576:bis(perfluorobutyl)ethene; D010100:Oxygen