Lack of effect of nasal salmon calcitonin on cell-mediated immunity.
The calcium lowering hormone, calcitonin, also affects the immune system. The effect of nasal salmon calcitonin on lymphocyte transformation tests and on serum-ionised calcium was investigated in a randomised, double-blind and placebo-controlled study including 24 healthy adult volunteers. The participants received a single dose of either 200 IU of nasal salmon calcitonin or nasal placebo in the morning and measurements were done before and 3 h after administration of the spray. Nasal salmon calcitonin exerted a significant hypocalcemic effect, but did not interfere with antigen- or mitogen-induced expansion of T-lymphocytes. It is unlikely that nasal salmon calcitonin affects cell-mediated immunity in healthy subjects.
Thamsborg
G
G
Department of Medicine, Sundby Hospital, Copenhagen, Denmark.
Møller
T
T
Kollerup
G
G
Sørensen
O H
OH
D000281:Administration, Intranasal; D000328:Adult; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male
C028815:salmon calcitonin; D002116:Calcitonin; D002118:Calcium