title: [Clinical utility of Gd-DTPA subtraction MR imaging for spinal bone metastasis].
abstract: Based on reports that Gd-DTPA contributes to the detection of tumors, we used it in 31 cases (97 lesions) of spinal bone metastases. The result was that Gd-DTPA increased the intensity of tumors and the surrounding bone marrow to almost the same level in 53%. To show the metastases clearly, an existing subtraction command system was utilized. The technique included the pixel-by-pixel method, to obtain a Gd-DTPA T1-weighted image (T1WI) subtracted by the original T1WI. The detectability of the subtraction image was improved up to 96%, but was less than the original T1WI (99%). Because of the different imaging rationale between two methods, a means to assess the quality of diagnosis must be proposed. To check the normal background, the same kind of postprocessing was performed in 21 patients without malignancy. Gd-DTPA perfusion was highest in the paravertebral veins, moderate in muscles and epidural fat, and lowest in the spinal cord, intervertebral disk and bone cortex. Gd-DTPA enhanced subtraction MR imaging provides a new diagnostic tool to detect and to assess bone metastasis.
authors: Department of Radiology, Tenri Hospital.
authors: K
authors: K
authors: Ando
authors: M
authors: M
authors: Murakami
authors: Y
authors: Y
authors: Kuroda
authors: A
authors: A
authors: Sano
authors: S
authors: S
authors: Nishizawa
authors: T
authors: T
authors: Masada
authors: S
authors: S
authors: Miyamoto
authors: Y
authors: Y
authors: Kigami
authors: S
authors: S
authors: Matsumoto
authors: Y
authors: Y
authors: Kojima
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D013382:Subtraction Technique
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA