Effects of D-glucose, L-glucose and D-mannitol on renal calcium handling and general renal function in the rat.
Standard renal clearance techniques were used to compare the effects of D-glucose, L-glucose and D-mannitol on renal calcium handling and general renal function in the anaesthetized rat. A significant (P < 0.01) calciuresis was seen in animals infused with D-glucose. This resulted from a decreased tubular reabsorption of calcium. A similar response was not seen with L-glucose or D-mannitol. The contrasting actions of the three sugars on tubular calcium transport may relate to their different transport characteristics, since only D-glucose is actively reabsorbed. Responses of the three sugars also differed with respect to fractional fluid and sodium reabsorption which were significantly (P < 0.001) lower in animals infused with L-glucose and D-mannitol, and plasma insulin concentrations which were significantly (P < 0.01) elevated only in the D-glucose group. An unexpected finding was a highly significant (P < 0.001) and progressive fall in glomerular filtration rate (GFR) in animals infused with L-glucose. The reasons for this are not known.
Boland
P S
PS
Department of Physiological Sciences, University of Manchester.
Garland
H O
HO
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005947:Glucose / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D017136:Ion Transport / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism; D013237:Stereoisomerism
D007328:Insulin; D008353:Mannitol; D012964:Sodium; D005947:Glucose; D002118:Calcium