[Long term biokinetics of 169Yb following injection as citrate, hydroxyethylethylenediaminetetraacetate and nitrilotriacetate].
169Yb complexes with known biokinetics in tumour-bearing mice up to 48 h p.i. were injected into healthy mice to study the radionuclide biodistribution in various organs and tissues for 672 h after injection, in order to obtain reliable biokinetic data in an animal model, not affected by tumour-growth, as a basis for the calculation of biological half-life and dose distribution. The results demonstrated the existence of at least two components with different biological half-lives in the organs and tissues investigated. The effective half-lives of these components decreased with increasing stability of the complexes administered. The effective half-life of the fast component was a few hours and that of the slow one between about 200 and 800 h.
Schomäcker
K
K
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln.
Scheidhauer
K
K
Franke
W G
WG
Weiss
S
S
Lindner
L
L
Jantsch
K
K
Shukla
S K
SK
Limouris
G S
GS
D000818:Animals; D002951:Citrates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019343:Citric Acid; D004492:Edetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009571:Nitrilotriacetic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011868:Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution; D015018:Ytterbium / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002951:Citrates; D011868:Radioisotopes; D019343:Citric Acid; D004492:Edetic Acid; D009571:Nitrilotriacetic Acid; D015018:Ytterbium; C026060:N-(hydroxyethyl)ethylenediaminetriacetic acid
Langzeitbiokinetik des 169Yb nach Injektion als Zitrat, Hydroxyethylethylen-diamintetraazetat und Nitrilotriazetat.