title: A pilot controlled study of fluoxetine for obsessive-compulsive symptoms in children with Tourette's syndrome.
abstract: We carried out a double-blind, randomized, parallel-groups clinical trial of fluoxetine (20-40 mg/day) and placebo in 11 children with Tourette's syndrome (TS) and associated obsessive-compulsive symptoms (OCS). The treatment period lasted 4 months. No significant differences between treatment groups were observed for measures of OCS. Fluoxetine therapy, however, was associated with a trend toward some improvement in tic severity, attentional abilities, and social functioning. Given these observations and the limitations of this pilot study, which include selection biases, small sample size, and significant placebo effects, the efficacy of fluoxetine in children with TS deserves further larger-scale investigation.
authors: Department of Neurology, University of Rochester School of Medicine and Dentistry, New York.
authors: R
authors: R
authors: Kurlan
authors: P G
authors: PG
authors: Como
authors: C
authors: C
authors: Deeley
authors: M
authors: M
authors: McDermott
authors: M P
authors: MP
authors: McDermott
mesh_terms: D000293:Adolescent; D002648:Child; D004311:Double-Blind Method; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D005879:Tourette Syndrome / Q000150:complications / Q000523:psychology*
chemical_list: D005473:Fluoxetine