title: Influence of the estrous cycle on the development of upper genital tract pathology as a result of chlamydial infection in the guinea pig model of pelvic inflammatory disease.
abstract: Guinea pigs were infected intravaginally with the chlamydial agent of guinea pig inclusion conjunctivitis at varying times during the estrous cycle. Genital tract tissues were collected 30 days after infection and processed for histopathological analysis. No difference was seen in the course of lower genital tract infection. However, a significantly greater percentage of tissues from animals infected on day 11 of the cycle were found to have chronic inflammation and fibrosis in the mesosalpinx compared to those from animals infected on day 6 or day 16. In addition, a significantly greater percentage of oviduct tissues from day 11-infected guinea pigs had marked tubal dilatation when compared to oviducts from day 6-or day 16-infected animals. The increased incidence of pathological changes was also noted in the endocervix, uterine fundus, and uterine horns but not the exocervix. These data indicate that the time of the estrous cycle and the corresponding hormonal influences may be an important influence on the development of upper genital tract disease.
authors: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
authors: R G
authors: RG
authors: Rank
authors: M M
authors: MM
authors: Sanders
authors: A T
authors: AT
authors: Kidd
mesh_terms: D000818:Animals; D002690:Chlamydia Infections / Q000150:complications*; D004971:Estrus; D005187:Fallopian Tubes / Q000473:pathology; D005260:Female; D005355:Fibrosis; D005831:Genital Diseases, Female / Q000209:etiology* / Q000473:pathology; D006168:Guinea Pigs; D000292:Pelvic Inflammatory Disease / Q000209:etiology* / Q000473:pathology