Urinary level of L-fucose as a marker of alcoholic liver disease.
The urinary levels of L-fucose were measured in 93 alcoholics; 20 of these were without liver disease, 57 with noncirrhotic alcoholic liver disease, and 16 with alcoholic liver cirrhosis. In addition, patients with cirrhosis due to viral infection, and healthy subjects were evaluated. The mean urinary L-fucose concentration showed significantly higher values in patients with alcoholic liver disease and alcoholic liver cirrhosis when compared with the healthy subjects or the chronic alcoholics without liver disease (p < 0.001). The urinary L-fucose level was also significantly higher (p < 0.001) in cases of alcoholic liver cirrhosis than in noncirrhotic alcoholic liver disease (384 +/- 97 vs. 240 +/- 95 mumol/g of creatinine). No difference was observed between the healthy subjects and chronic alcoholics without liver disease (143 +/- 29 vs. 155 +/- 60 mumol/g of creatinine). The urinary level of L-fucose was significantly higher with alcoholic cirrhosis (384 +/- 97 mumol/g of creatinine) than with viral cirrhosis (265 +/- 42 mumol/g of creatinine) (p < 0.001). The measurement of urinary L-fucose may be a useful marker of alcoholic liver disease.
Yamauchi
M
M
First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Kimura
K
K
Maezawa
Y
Y
Ohata
M
M
Mizuhara
Y
Y
Hirakawa
J
J
Nakajima
H
H
Toda
G
G
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D001706:Biopsy; D005643:Fucose / Q000652:urine*; D006801:Humans; D008099:Liver / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis / Q000473:pathology / Q000652:urine; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis* / Q000473:pathology / Q000652:urine; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D005643:Fucose