Suppression of tuftsin activity by the partial sequences of adenovirus type 2 proteins.
The synthesis of tuftsin inhibitor-like partial sequences of adenovirus type 2 proteins: TVPPR (1), TRPPR (2), TGPPT (3), PRPPT (4), FVPPR (5), ARPPA (6) and YGPPK (7) are described. The choice of peptides for synthesis was performed by using a simple computer-aided method for predicting antigenic determinants of proteins. For all these peptides an inhibitory activity against tuftsin was found.
Siemion
I Z
IZ
Institute of Chemistry, Wrocław University, Poland.
Słoń
J J
JJ
Wieczorek
Z
Z
D000260:Adenoviruses, Human / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D013329:Structure-Activity Relationship; D014405:Tuftsin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015678:Viral Structural Proteins / Q000737:chemistry / Q000494:pharmacology*
D009842:Oligopeptides; D015678:Viral Structural Proteins; D014405:Tuftsin