Propofol and fentanyl act additively for induction of anaesthesia.
The induction dose-response of propofol was compared with the dose-response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose-response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty-three percent of the ED50 of fentanyl was required in combination with 75% of the ED50 for propofol to achieve the ED50 of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.
Ben-Shlomo
I
I
Department of Anaesthesia, Rebecca Sieff Hospital, Safed, Israel.
Finger
J
J
Bar-Av
E
E
Perl
A Z
AZ
Etchin
A
A
Tverskoy
M
M
D000328:Adult; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D005283:Fentanyl; D006801:Humans; D008875:Middle Aged; D015742:Propofol
D005283:Fentanyl; D015742:Propofol