Fatal disseminated adenovirus type 2 infection following bone marrow transplantation for Hurler's syndrome: a primary infection.
A 5-month-old girl given an allogeneic bone marrow transplant for Hurler's syndrome succumbed to fatal pneumonia 5 weeks after the transplant. Adenovirus type 2 was isolated from her urine before she died. Immunoperoxidase and electron microscopical studies of liver and lungs post mortem confirmed a disseminated adenovirus infection. The serological findings and the patient's young age suggested that the infection was a primary one. The importance of considering exogenous sources of adenovirus infection in bone marrow transplant recipients is discussed.
Morris
D J
DJ
Department of Virology, Booth Hall Children's Hospital, Manchester, U.K.
Corbitt
G
G
Bailey
A S
AS
Newbould
M
M
Smith
E
E
Picton
S
S
Stevens
R F
RF
D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000209:etiology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008059:Mucopolysaccharidosis I / Q000628:therapy*