Isolation and characterization of four polyether antibiotics, X-14889A, B, C, and D, closely related to lysocellin and the ferensimycins.
Streptomyces sp. X-14889 (NRRL 15517) has been found to produce a number of novel polyether antibiotics and an orange pigment. One of the antibiotics, X-14889B (3) was identified as ferensimycin A, which in turn is an isomer of the well-studied polyether antibiotic, lysocellin (1). Of the three other antibiotics, X-14889C (4) is a lower homolog of ferensimycin A and antibiotics X-14889A (2) and D (5) which are respectively the descarboxy and anhydro-descarboxy forms of this same molecule. The latter compound, X-14889D is of interest as it contains an ether bridge across the terminal tetrahydrofuranyl ring in an analogous relationship to that reported earlier for antibiotics X-14873A (6) and G.
Westley
J W
JW
Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110.
Liu
C M
CM
Blount
J F
JF
Todaro
L
L
Sello
L H
LH
Troupe
N
N
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D008968:Molecular Conformation; D013302:Streptomyces / Q000378:metabolism*; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D005663:Furans; C009818:lysocellin; C036272:ferensimycin A; C080563:X 14889D; C080562:X 14889C; C080561:X 14889A