Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene.
The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.
Shamaan
N A
NA
Jabatan Biokimia dan Mikrobiologi, Universiti Pertanian Malaysia.
Wan Ngah
W Z
WZ
Ibrahim
R
R
Jarien
Z
Z
Top
A G
AG
Abdul Kadir
K
K
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control; D051381:Rats; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology
D014810:Vitamin E; D015073:2-Acetylaminofluorene; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase