title: Contraception in older woman.
abstract: Oral contraception (OC) in the premenopause has been recently proposed as treatment for control and prevention of the putative symptoms typical of this period of life. Indeed, menstrual cycle disturbances and climacteric symptoms frequently occur at this age. The major aim of normal contraception is resultant maintenance of normal sexual activity. The effects of one OC containing 20 mcg ethinylestradiol and 150 mcg desogestrel (EE/DOG) were studied. Treatment did not significantly modify both lipid metabolism (triglycerides, total cholesterol, HDL, LDL, Apo A, Apo B) and clotting system (fibrinogen, PT, PTT, antithrombin III, fibrinopeptide A). No significant modifications of oral glucose tolerance test (OGGT) occurred after EE/DOG treatment. Also, bone density was not modified during estro-progestinic administration. From our experience, if there are no risk factors such as smoking, obesity or hypertension, the OCs could be used until menopause for absolute contraceptive efficacy, good tolerance and lack of side effects.
authors: Department of Obstetrics and Gynecology, University of Cagliari, Italy.
authors: A
authors: A
authors: Volpe
authors: M
authors: M
authors: Silferi
authors: A D
authors: AD
authors: Genazzani
authors: A R
authors: AR
authors: Genazzani
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001940:Breast / Q000187:drug effects; D002979:Climacteric / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000494:pharmacology*; D017135:Desogestrel / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008597:Menstrual Cycle / Q000187:drug effects*; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
chemical_list: D001779:Blood Coagulation Factors; D003277:Contraceptives, Oral, Combined; D008055:Lipids; D012738:Sex Hormone-Binding Globulin; D004997:Ethinyl Estradiol; D017135:Desogestrel; D005947:Glucose