title: Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase.
abstract: Palbinone, a novel terpenoid isolated from the roots of Paeonia albiflora, showed a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol. The structures of palbinone and a known compound, paeonilactone-B isolated from the active fraction of this plant were determined by the use of 2D NMR techniques (1H-1H COSY, 1H-13C COSY, 1H-13C long-range COSY, and HMBC).
authors: Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
authors: S
authors: S
authors: Kadota
authors: S
authors: S
authors: Terashima
authors: P
authors: P
authors: Basnet
authors: T
authors: T
authors: Kikuchi
authors: T
authors: T
authors: Namba
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases; D006913:Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D013729:Terpenes; C080910:palbinone; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases