title: Effects of transient coronary artery occlusion on canine intrinsic cardiac neuronal activity.
abstract: In order to further elucidate the regulatory function of canine epicardial neurons, the effects of transient coronary artery occlusion on their spontaneous activity was studied. Fifty-eight individual, spontaneously active units were identified by means of their action potential configurations in specific loci of atrial and ventricular epicardial fat of 10 anesthetized dogs. The activity of 49 of the units was modified by one minute of coronary artery occlusion. Twenty-four of the 49 responding units exhibited increased activity and 37 decreased activity during coronary artery occlusions. Activity changes were sometimes, but not always, associated with decreased left ventricular intramyocardial systolic pressure. During reperfusion, the activity of 6 units was increased compared to control levels, even though ventricular pressures remained the same. Following acute decentralization, 48% of previously active units generated spontaneous activity; the activity of 89% of these was altered during coronary artery occlusion despite the fact that overall cardiodynamics were unchanged. Following hexamethonium administration, the activity generated by 9 of 10 spontaneously active units was modified by coronary artery occlusion. It is concluded that transient coronary artery occlusion can modify the activity generated by intrinsic cardiac neurons, such modification involving central and peripheral neuronal interactions.
authors: Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
authors: M H
authors: MH
authors: Huang
authors: J L
authors: JL
authors: Ardell
authors: B D
authors: BD
authors: Hanna
authors: S G
authors: SG
authors: Wolf
authors: J A
authors: JA
authors: Armour
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology; D004285:Dogs; D004567:Electrodes, Implanted; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology; D006321:Heart / Q000294:innervation* / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D008297:Male; D008839:Microelectrodes; D009121:Muscle Denervation; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology; D018733:Nicotinic Antagonists
chemical_list: D018733:Nicotinic Antagonists