Polyneuropathy due to ethylene oxide, propylene oxide, and butylene oxide.
Axonal neuropathy occurs due to occupational ethylene oxide (EtO) exposure. The experimental model of human EtO neuropathy was established. In addition, the neurotoxic effects of propylene oxide (PpO) and butylene oxide (BtO) were demonstrated in rats. Although no human neuropathy due to PpO or BtO is reported, both chemicals must be considered to be neurotoxic, based on this study.
Ohnishi
A
A
Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Murai
Y
Y
D000818:Animals; D004195:Disease Models, Animal; D004852:Epoxy Compounds / Q000009:adverse effects* / Q000506:poisoning; D005027:Ethylene Oxide / Q000009:adverse effects* / Q000506:poisoning; D006801:Humans; D009410:Nerve Degeneration / Q000187:drug effects / Q000502:physiology; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D016273:Occupational Exposure; D051381:Rats; D017208:Rats, Wistar
D004852:Epoxy Compounds; C027488:1,2-epoxybutane; D005027:Ethylene Oxide; C009068:propylene oxide