title: Prognostic significance of the onset mode in parkinsonism.
abstract: Early recognition of the prognosis in parkinsonism is important for both the management and studies aimed at preventing progression of disease. Less favorable prognosis is reported in early-onset postural instability and gait difficulty (PIGD) than in the tremor-onset cases, but the reasons for this are unknown. In 70 autopsy-verified cases, 11 (15.7%) had PIGD, and 34 (49%) had tremor onset. Improvement on levodopa was more common in the tremor-than the PIGD-onset cases (p < 0.05). The majority of tremor-onset cases had Lewy body disease, while the majority of PIGD-onset cases had other forms of pathology. Survival was shorter in the PIGD- than the tremor-onset cases (p < 0.05).
authors: Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
authors: A H
authors: AH
authors: Rajput
authors: R
authors: R
authors: Pahwa
authors: P
authors: P
authors: Pahwa
authors: A
authors: A
authors: Rajput
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis*; D011379:Prognosis; D014202:Tremor / Q000209:etiology