[Effect of medroxyprogesterone acetate on antitumor efficacies and side effect of 5-fluorouracil].
Effect of medroxyprogesterone acetate (MPA) on the lethal toxicity, bone marrow toxicity and antitumor efficacies of 5-fluorouracil (5-FU) was examined. The following results were obtained. In aged female ddY mice, the lethal toxicity and body weight loss caused by 5-FU were reduced by MPA. MPA also reduced the bone marrow toxicity of 5-FU in aged female ddY mice. These effects of MPA were not observed in young male ddY mice. Moreover, MPA did not affect the antitumor activity of 5-FU against MPA-insensitive mouse breast carcinoma FM3A, or rather augmented its antitumor activity against MPA-sensitive human breast carcinoma MCF-7. These results indicate that MPA reduces the side effects of 5-FU and augments the antitumor activity of 5-FU in female mice.
Ashizawa
T
T
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
Ishida
H
H
Okabe
M
M
Gomi
K
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D007928:Lethal Dose 50; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D051379:Mice; D008809:Mice, Inbred C3H
D017258:Medroxyprogesterone Acetate; D005472:Fluorouracil