[Beta-carbolines (harman/norharman) are increased in heroin dependent patients].
Endogenous substances resulting from interactions between alcohol and possibly opioid metabolites and neurotransmitters (dopamine, indolamines) are mediators of the pathochemical process towards dependence. Beta-carbolines are increased in alcoholics and--according to our own results--in heroin-addicts. Still unclear is the impact of other psychopathological disturbances like states of anxiety or depression; unclear is also, if it has to be interpreted as state, trait or residual marker of the dependence syndrome.
Stohler
R
R
Psychiatrische Universitätsklinik, Basel.
Rommelspacher
H
H
Ladewig
D
D
Dammann
G
G
D000328:Adult; D002243:Carbolines; D005260:Female; D006247:Harmine / Q000031:analogs & derivatives* / Q000097:blood; D006556:Heroin Dependence / Q000097:blood* / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000097:blood
D002243:Carbolines; D006247:Harmine; C005010:harman; C010262:norharman; D008691:Methadone
Beta-Carboline (Harman/Norharman) sind bei Heroinabhängigen erhöht.