N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist.
Forbes
I T
IT
Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex, England.
Kennett
G A
GA
Gadre
A
A
Ham
P
P
Hayward
C J
CJ
Martin
R T
RT
Thompson
M
M
Wood
M D
MD
Baxter
G S
GS
Glen
A
A
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology
D007211:Indoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C080864:N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea; D014508:Urea