title: Topical treatment of pulmonary aspergilloma by antifungals. Relationship between duration of the disease and efficacy of therapy.
abstract: Twelve patients with aspergilloma were treated with intracavitary or endobronchial administration of antifungals. Patients with successful therapy had significantly shorter mean duration of the disease course (3.6 months) than the less effective group (44.4 months, p < 0.01). Minimal inhibitory concentrations of antifungal agents against isolated strains of aspergilli were considerably lower than estimated intracavitary concentrations of the antifungals. A pathologic examination suggested that the old mycetoma was for the most part comprised of dead mycelial cells, against which antifungal agents were not effective. However, clinical improvement was obtained, regardless of the roentgenographic improvement. Our study suggested that early diagnosis and therapy are recommended to achieve better therapeutic effect.
authors: Second Department of Internal Medicine, School of Medicine, Nagasaki University, Japan.
authors: H
authors: H
authors: Yamada
authors: S
authors: S
authors: Kohno
authors: H
authors: H
authors: Koga
authors: S
authors: S
authors: Maesaki
authors: M
authors: M
authors: Kaku
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000494:pharmacology; D005437:Flucytosine / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007322:Instillation, Drug; D008168:Lung / Q000000981:diagnostic imaging; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011859:Radiography; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D008825:Miconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine