title: Synthesis of the metabolite N-hydroxy-desferrioxamine B.
abstract: N-Hydroxy-desferrioxamine B (5), a postulated metabolite of the microbial product desferrioxamine B (1), has been prepared by reduction of the intermediate oxime 6 with sodium cyanoborohydride. The oxime was obtained by selective oxidation of desferrioxamine B with hydrogen peroxide and a catalytic amount of sodium tungstate dihydrate. The iron complex derived from 5 enabled definite proof of the structure of one of four metabolites of desferrioxamine B found in urine samples of patients treated with this drug.
authors: Biotechnology Research Laboratories, CIBA-GEIGY Limited, Basel, Switzerland.
authors: B E
authors: BE
authors: Roggo
authors: H H
authors: HH
authors: Peter
mesh_terms: D003676:Deferoxamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism*
chemical_list: C080564:N-hydroxydesferrioxamine B; D003676:Deferoxamine