Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs.
We have investigated the effects of antipsychotic drugs on the expression of the two dopamine D2 receptor splicing variants using multiprobe oligonucleotide solution hybridisation. Both long and short mRNA variants were increased in abundance by approximately 2-fold by both haloperidol and loxapine after 32 days drug administration.
Buckland
P R
PR
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
O'Donovan
M C
MC
McGuffin
P
P
D017398:Alternative Splicing; D000704:Analysis of Variance; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D014644:Genetic Variation; D006220:Haloperidol / Q000494:pharmacology*; D008152:Loxapine / Q000494:pharmacology*; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D013997:Time Factors; D015854:Up-Regulation / Q000187:drug effects*
D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D006220:Haloperidol; D008152:Loxapine