Liposomes as carriers of antimicrobial agents or immunomodulatory agents in the treatment of infections.
Targeting of antimicrobial agents by means of liposomes is under investigation and may be of importance in the treatment of infections that prove refractory to conventional forms of antimicrobial treatment. The ability to achieve a significantly longer residence time of liposomes in plasma and limited uptake of liposomes by the mononuclear phagocyte system opens up new areas of investigation and potential therapeutic application. By manipulating the liposomal composition, rates of uptake and intracellular degradation can be influenced and thereby the rates at which liposome-encapsulated agents are released and become available to exert their therapeutic action. With respect to the targeting of macrophage modulators at the mononuclear phagocyte system by means of liposomes for maximal stimulation of the nonspecific antimicrobial resistance, experimental evidence is now available of the potential usefulness of liposomes as carriers of these agents. This approach may also be of importance for the potentiation of treatment of severe infections.
Bakker-Woudenberg
I A
IA
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands.
Lokerse
A F
AF
ten Kate
M T
MT
Melissen
P M
PM
van Vianen
W
W
van Etten
E W
EW
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D006801:Humans; D007113:Immunity, Innate; D008081:Liposomes / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D008262:Macrophage Activation; D009000:Monocytes / Q000378:metabolism / Q000502:physiology; D009181:Mycoses / Q000188:drug therapy; D013997:Time Factors
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D008081:Liposomes