title: Ganglioside distribution in the liver of inbred strains of rats and the cancerous liver of LEC rats.
abstract: The gangliosides in the livers of various inbred strains of rats and hepatoma of LEC rats were purified and analyzed by thin-layer chromatography. The patterns of ganglioside distribution in these rat livers were classified into three phenotypes depending on the strain, that is, a-type (ACI, LEA, LEW, BUF), b-type (WKAH, SHR/SP), and LEC type, which are characterized by dominance of a- or b-series of gangliosides, or a variation of a-type, respectively. A sex difference was also recognized in the molar ratio of GM3 which was much higher in males (60-75%) than in females (33-56%) except in LEC rats. In addition, the content of a-series gangliosides was lower and the content of b-series gangliosides was higher in a-type male rats than in a-type female rats. The opposite was true in b-type rats. LEC rats were an exception, characterized by no sex difference and a quite low content of b-series gangliosides. The LEC rat is a mutant strain that spontaneously develops fulminant hepatitis around 14 to 20 weeks of age and hepatoma at 1 to 1.5 years old. The gangliosides of the hepatoma were characterized by the appearance of the newly synthesized gangliosides, fucosyl-GM1 and alpha-galactosyl alpha-fucosyl GM1 (BGM1). In particular, BGM1 ganglioside accumulated in the hepatoma of female rats.
authors: Institute for Animal Experimentation, Hokkaido University School of Medicine.
authors: N
authors: N
authors: Kasai
authors: A
authors: A
authors: Kamimura
authors: I
authors: I
authors: Miyoshi
authors: T
authors: T
authors: Ariga
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D005260:Female; D005732:Gangliosides / Q000096:biosynthesis / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012727:Sex Characteristics; D013045:Species Specificity
chemical_list: D005732:Gangliosides