Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.
We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.
Taillan
B
B
Service de Médecine Interne, Hôpital de Cimiez, Nice, France.
Garnier
G
G
Castanet
J
J
Ferrari
E
E
Pesce
A
A
Dujardin
P
P
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*
D008727:Methotrexate