5'-Nor-anhydrovinblastine (Navelbine) has an anti-invasive effect on MO4 mouse fibrosarcoma cells in vitro and in vivo.
5'-nor-anhydrovinblastine (Navelbine) is a hemisynthetic Vinca alkaloid for which a selectivity for mitotic microtubules has been demonstrated. In previous studies, we have demonstrated an anti-invasive effect of other Vinca alkaloids. Here the results of in vitro and in vivo assays concerning the effect of 5'-nor-anhydrovinblastine on growth and invasion of MO4 cells are presented. It is demonstrated that at cytostatic concentrations, 5'-nor-anhydrovinblastine also has an anti-invasive effect.
Van den Berge
D
D
Oncologic Centre AZ-VUB, Department of Radiotherapy, Eenheid Kanker, Vrije Universiteit Brussel, Belgium.
Bruyneel
E
E
Distelmans
W
W
Van Belle
S
S
Krikonian
A
A
Breillout
F
F
Storme
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002464:Cell Migration Inhibition; D002642:Chick Embryo; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D009361:Neoplasm Invasiveness; D013778:Tetrazolium Salts; D013844:Thiazoles; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D014747:Vinblastine; C022616:thiazolyl blue; D000077235:Vinorelbine