title: [Amyloidosis as cause of severe abdominal symptoms in a young Somali immigrant?].
abstract: Extensive deposition of amyloid was detected in the digestive tract of a Somali woman aged 20 yr with abdominal pain, diarrhoea and cachexia. Immunohistochemical characterisation showed that the amyloid protein involved was of the AA type. Elevated levels were also found for serum amyloid A (SAA), an acute-phase protein which is the precursor of AA amyloid. The underlying inflammatory disease was peritoneal tuberculosis. The normalisation of the SAA levels and the recovery of the small intestine during tuberculostatic therapy showed that the tuberculosis was the cause of the enteropathy. This case report highlights the importance of early detection and effective treatment of the underlying inflammatory disease in case of AA amyloidosis.
authors: Academisch Ziekenhuis, Groningen.
authors: H T
authors: HT
authors: Heslinga
authors: B P
authors: BP
authors: Hazenberg
authors: F T
authors: FT
authors: Peters
authors: J D
authors: JD
authors: Elema
authors: J T
authors: JT
authors: Steensma
authors: M H
authors: MH
authors: van Rijswijk
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000995:Antitubercular Agents / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D006801:Humans; D007583:Jejunum / Q000473:pathology; D014395:Peritonitis, Tuberculous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000685:Serum Amyloid A Protein / Q000302:isolation & purification
chemical_list: D000995:Antitubercular Agents; D000685:Serum Amyloid A Protein
vernacular_title: Amyloidosis als oorzaak van ernstige buikklachten bij een jonge Somalische immigrante?