title: L-[2-18F]fluorophenylalanine and L-[U-14C]phenylalanine: a comparative study of their transport to rat brain.
abstract: The transport rates of L-[2-18F]fluorophenylalanine ([18F]Phe) and L-[U-14C]phenylalanine ([14C]Phe) across the blood-brain barrier were compared in saline, large neutral amino acids (NAA) and large basic amino acids (BAA) loaded rats. The fraction of transported tracer (FTT) was expressed as the ratio of brain radioactivity to integrated plasma radioactivity at 5 min after injection of the tracers. Cerebral FTTs of [18F]Phe and [14C]Phe in the control group were 0.042 and 0.045, respectively, and decreased to 0.016 and 0.019 in the NAA loaded group. The ratios of FTT of [18F]Phe and that of [14C]Phe were approx. 0.90, and did not differ among the three groups. These results indicate that the transport of [18F]Phe from the blood to the brain can be considered to be mediated by the NAA transport system and that its transport rate is almost the same as that of [14C]Phe.
authors: Department of Internal Medicine.
authors: H
authors: H
authors: Nakamichi
authors: M
authors: M
authors: Murakami
authors: S
authors: S
authors: Miura
authors: Y
authors: Y
authors: Kondoh
authors: S
authors: S
authors: Mizusawa
authors: Y
authors: Y
authors: Ono
mesh_terms: D000596:Amino Acids / Q000097:blood; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D002531:Cerebellum / Q000378:metabolism; D005461:Fluorine / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000596:Amino Acids; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D005461:Fluorine; D010649:Phenylalanine