title: Age-dependent decline in cognitive information processing of HIV-positive individuals detected by event-related potential recordings.
abstract: Cognitive event-related potentials (ERP) were recorded in 100 HIV-positive patients of all CDC stages without clinical CNS deficits with an auditory oddball paradigm. Four latency peaks and three amplitudes were evaluated (N1, P2, N2 and P3 latencies, N1-P2, P2-N2 and N2-P3 amplitudes). In contrast to an age-matched control group of comparable education and social environment, a statistically significant N2-P3 amplitude reduction was found in the patient group deteriorating with the CDC stages. The physiological N2-P3 amplitude reduction with age in normals was found to be twice as fast in HIV-positive individuals. No group-statistically relevant EEG abnormalities were found in the patient group. In psychometric testing, there was no marked depressive syndrome in the HIV-positive individuals, but a mild slowing of speed-dependent abilities.
authors: Department of Neurology, University of Düsseldorf, Germany.
authors: G
authors: G
authors: Arendt
authors: H
authors: H
authors: Hefter
authors: H W
authors: HW
authors: Nelles
authors: F
authors: F
authors: Hilperath
authors: G
authors: G
authors: Strohmeyer
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D003071:Cognition; D004569:Electroencephalography; D004594:Electrophysiology; D005260:Female; D006679:HIV Seropositivity / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics / Q000379:methods