title: [Captopril in a single daily dose in arterial hypertension in the elderly. The Badajoz cooperative study. The Badajoz Cooperative Group].
abstract: The response to the therapy with captopril administered in one daily dose (between 25 and 100 mg) to a group of 468 old patients with arterial hypertension has been studied. In 87% of the cases, normalization of the arterial pressure was achieved at six months (values lower than 160/95 mmHg). The therapy resulted in a progressive reduction during the follow-up period, with a significant initial reduction (p < 0.001). Just 7.5% of the patients needed the administration of diuretics in addition to the therapy. Just nine patients had to discontinue the follow-up due to side effects (dry cough in 4; gastrointestinal disorders in 4; postural hypertension in 1 case). We conclude that captopril administered in one daily dose is a safe and effective therapy for the treatment of mild to moderate arterial hypertension among the elderly.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage* / Q000009:adverse effects; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002216:Captopril
vernacular_title: Captopril en dosis única diaria en la hipertensión arterial del anciano. Estudio cooperativo de Badajoz. Grupo Cooperativo de Badajoz.