title: Physical mapping of the holoprosencephaly critical region on chromosome 7q36.
abstract: Holoprosencephaly (HPE) is a developmental field defect involving the brain and face. Cytogenetic deletions in patients with HPE have localized one of the HPE genes to chromosomal region 7q36. We have characterized the 7q deletions in thirteen HPE patients. The result is the construction of a high resolution physical map of 7q32-qter. As a first step towards cloning an HPE gene crucial for normal brain development, we have defined the HPE minimal critical region in 7q36 between D7S292 and D7S392.
authors: Children's Hospital of Philadelphia, Pennsylvania.
authors: F
authors: F
authors: Gurrieri
authors: B J
authors: BJ
authors: Trask
authors: G
authors: G
authors: van den Engh
authors: C M
authors: CM
authors: Krauss
authors: A
authors: A
authors: Schinzel
authors: M J
authors: MJ
authors: Pettenati
authors: D
authors: D
authors: Schindler
authors: J
authors: J
authors: Dietz-Band
authors: G
authors: G
authors: Vergnaud
authors: S W
authors: SW
authors: Scherer
mesh_terms: D000328:Adult; D002460:Cell Line; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D005333:Fetus; D017353:Gene Deletion; D016142:Holoprosencephaly / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction