title: Uniparental inheritance of the mitochondrial gene cytochrome b in Plasmodium falciparum.
abstract: The inheritance of an extrachromosomal 6-kb element has been examined in the human malaria parasite Plasmodium falciparum. A single base pair difference in the cytochrome b gene from the 6-kb element of two different cloned lines of the parasite was identified, and used as a marker in a cross in the mosquito stage of the life cycle. Analysis of 59 individual hybrid oocysts resulting from this cross clearly demonstrated that inheritance of the cytochrome b gene was uniparental. This observation makes it possible to investigate the inheritance and evolution of cytoplasmic traits, including certain forms of drug resistance, in natural populations of this parasite.
authors: Institute of Cell Animal and Population Biology, University of Edinburgh, Scotland, UK.
authors: A M
authors: AM
authors: Creasey
authors: L C
authors: LC
authors: Ranford-Cartwright
authors: D J
authors: DJ
authors: Moore
authors: D H
authors: DH
authors: Williamson
authors: R J
authors: RJ
authors: Wilson
authors: D
authors: D
authors: Walliker
authors: R
authors: R
authors: Carter
mesh_terms: D000818:Animals; D001483:Base Sequence; D003573:Cytochrome b Group / Q000235:genetics*; D004277:DNA, Single-Stranded; D017125:Genes, Protozoan; D014644:Genetic Variation; D008928:Mitochondria / Q000201:enzymology*; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000201:enzymology / Q000235:genetics*
chemical_list: D003573:Cytochrome b Group; D004277:DNA, Single-Stranded