[Acute reversible liver necrosis after valproate therapy (immunologic hypersensitivity)].
We describe a case of a 9-year-old boy with the severe acute liver injury caused by idiosyncrasy after the administration of valproate. The liver biopsy performed during the first days after the onset of the disease revealed the necrosis of more than 50% of hepatocytes but the injury was almost fully reversible which was well demonstrated by the second biopsy five months later. After five years an evidence for the immunologic idiosyncrasy caused by valproate was still present, which was demonstrated in vitro by blastic transformation of lymphocytes from the patient. The boy is quite healthy and epilepsy is under control of suximide. The family was informed that the boy could be treated with valproate never more.
Nevoral
J
J
1. Universitäts-Kinderklinik Prag-Motol, Tschechien.
Janda
J
J
Hanika
J
J
Svec
M
M
Honzová
S
S
D002648:Child; D004342:Drug Hypersensitivity; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000201:enzymology / Q000276:immunology; D000637:Transaminases / Q000097:blood; D014635:Valproic Acid / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use
D014635:Valproic Acid; D000637:Transaminases
Akute Reversible Lebernekrose nach Valproat-Behandlung (immunologisch bedingte Idiosynkrasie).