Investigation of possible metabolism of pigment yellow 17, a 3,3'-dichlorobenzidine-based pigment, after inhalation exposure in rats.
Rats were exposed by inhalation to the technically highest administrable concentration of 230 mg Pigment Yellow 17/m3 air for 4 h. Inhalability of the dust was guaranteed by a mass-median aerodynamic diameter of 1.0-1.1 microns. For 14 days after exposure, urine and serum samples were analysed for 3,3'-dichlorobenzidine, the parent carcinogenic amine of the test compound. No 3,3'-dichlorobenzidine could be detected either in urine or blood, the detection limit being 5 ng/ml for both media. Based on the results of this study there is no evidence for metabolic cleavage of Pigment Yellow 17 to 3,3'-dichlorobenzidine in the rat.
Hofmann
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Hoechst Aktiengesellschaft, Pharma Entwicklung Toxikologie, Frankfurt/Main, Germany.
Schmidt
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D
D015101:3,3'-Dichlorobenzidine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D000280:Administration, Inhalation; D000818:Animals; D001372:Aza Compounds / Q000378:metabolism* / Q000493:pharmacokinetics; D001682:Biological Availability; D005260:Female; D008297:Male; D010316:Particle Size; D010860:Pigments, Biological / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
D001372:Aza Compounds; D010860:Pigments, Biological; D015101:3,3'-Dichlorobenzidine; C080899:Pigment Yellow 17