title: Acute hemodynamic and respiratory effects of amniotic fluid embolism in the pregnant goat model.
abstract: OBJECTIVE
  Our purpose was to determine the acute-phase central hemodynamic and respiratory effects of raw, filtered, filtered and boiled, and meconium-containing amniotic fluid.
  
  
  METHODS
  Pregnant goats (Capra hircus) in the last one third of pregnancy were given freshly collected autologous amniotic fluid in a volume of 2.5 ml/kg of body weight. Observations were then made at 10, 30, 60, 120, and 180 minutes after amniotic fluid embolism. Pulmonary artery catheters and femoral artery lung water catheters were placed for specimen and data collection.
  
  
  RESULTS
  Marked pressor responses were observed in both the pulmonary and systemic circulations with all amniotic fluid infusions. The pressor response was similar with raw, filtered, and filtered and boiled amniotic fluid. The pressor response seen with amniotic fluid containing meconium was significantly greater than that seen with the other forms. No significant effects were observed on cardiac or respiratory function except in the meconium group, where transient left ventricular dysfunction was accompanied by an acute increase in extravascular lung water and dysoxia.
  
  
  CONCLUSIONS
  The Capra hircus model is appropriate for the further study of amniotic fluid embolism. The acute pressor effects are transient and involve both the systemic and pulmonary circulations. Left ventricular dysfunction and dysoxia were observed only with embolism of amniotic fluid containing meconium.
authors: Department of Obstetrics and Gynecology, Wilford Hall USAF Medical Center SGHO, Lackland AFB, TX 78236-5300.
authors: G D
authors: GD
authors: Hankins
authors: R R
authors: RR
authors: Snyder
authors: S L
authors: SL
authors: Clark
authors: L
authors: L
authors: Schwartz
authors: W R
authors: WR
authors: Patterson
authors: C A
authors: CA
authors: Butzin
mesh_terms: D000653:Amniotic Fluid; D000818:Animals; D004195:Disease Models, Animal; D004617:Embolism / Q000503:physiopathology*; D005260:Female; D006041:Goats; D006439:Hemodynamics; D008470:Meconium; D011247:Pregnancy; D015656:Respiratory Mechanics