Effects of nisoldipine on hypertension and glomerulosclerosis in Cohen diabetic rat with Goldblatt hypertension.
Nisoldipine treatment for five months prevented a rise in blood pressure in Cohen diabetic rats with Goldblatt hypertension, compared to a significant elevation in untreated controls. Blood creatinine and urea also decreased significantly in the treated animals, and renal lesions were less severe. The prevalence of glomerulosclerosis, however, remained unaltered in both the treated and control groups. These findings indicate that increased blood pressure aggravates renal changes, while reducing it eliminates the aggravation.
Rosenthal
T
T
Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Rosenmann
E
E
Cohen
A M
AM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D006978:Hypertension, Renovascular / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D015737:Nisoldipine / Q000627:therapeutic use*; D010758:Phosphorus / Q000097:blood; D051381:Rats
D010758:Phosphorus; D015737:Nisoldipine; D003404:Creatinine