title: Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice.
abstract: Despite extensive study, the immunologic mechanisms mediating allograft rejection have not been completely defined. In the current study, we evaluated the T cell subsets important in islet allograft, skin allograft, and islet xenograft rejection using a genetically engineered line of mice deficient in beta 2-microglobulin expression. Because these mice lack cell surface MHC class I expression, they are deficient in T cells of the CD8 subset (class I-restricted cytotoxic T cells). Pancreatic islet allografts transplanted to CD8+ T cell-deficient recipients showed prolonged survival compared with controls. No prolongation was observed in the survival of pancreatic islet xenografts or in the survival of skin allografts transplanted to the CD8+ T cell--deficient hosts. We conclude that CD8+ T cells play a prominent role in islet allograft, but not islet xenograft or skin allograft, rejection in mice.
authors: Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.
authors: N M
authors: NM
authors: Desai
authors: H
authors: H
authors: Bassiri
authors: J
authors: J
authors: Kim
authors: B H
authors: BH
authors: Koller
authors: O
authors: O
authors: Smithies
authors: C F
authors: CF
authors: Barker
authors: A
authors: A
authors: Naji
authors: J F
authors: JF
authors: Markmann
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000032:analysis*; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000502:physiology; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D008297:Male; D051379:Mice; D016038:Skin Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014183:Transplantation, Heterologous / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology*
chemical_list: D016827:CD8 Antigens