title: Cluster B personality disorder characteristics predict outcome in the treatment of bulimia nervosa.
abstract: The Personality Disorders Examination (PDE) was administered to 71 bulimia nervosa patients at baseline assessment in a study comparing the effectiveness of cognitive-behavioral treatment with desipramine or the combination of both treatments. Personality disorder subscales were combined into single DSM-III-R cluster scores. A high cluster B score (consisting of antisocial, borderline, histrionic, and narcissistic features) significantly predicted poor outcome at 16 weeks and was a better predictor of outcome than borderline personality characteristics alone or any other DSM-III-R cluster score or combination of cluster scores. In contrast pretreatment depression level, self-esteem, degree of dietary restraint, frequency of purging, and history of anorexia nervosa were not significantly related to outcome. At 1-year follow-up there was still a trend toward high cluster B scores predicting poor treatment outcome. Cluster B score was not significantly correlated with percentage of sessions attended nor did subjects with higher cluster B scores have a better outcome with either specific treatment. These results suggest that further investigation of alternative treatments is warranted with high cluster B individuals to determine if treatment effectiveness can be improved.
authors: Department of Psychiatry, Stanford University School of Medicine, CA 94305.
authors: E M
authors: EM
authors: Rossiter
authors: W S
authors: WS
authors: Agras
authors: C F
authors: CF
authors: Telch
authors: J A
authors: JA
authors: Schneider
mesh_terms: D000293:Adolescent; D000328:Adult; D001828:Body Image; D001883:Borderline Personality Disorder / Q000523:psychology / Q000628:therapy; D002032:Bulimia / Q000523:psychology / Q000628:therapy*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy; D003891:Desipramine / Q000627:therapeutic use*; D005247:Feeding Behavior / Q000523:psychology; D005260:Female; D006801:Humans; D010552:Personality Assessment; D010554:Personality Disorders / Q000523:psychology / Q000628:therapy*; D012649:Self Concept
chemical_list: D003891:Desipramine