IV bolus administration of subconvulsive doses of lignocaine to conscious sheep: myocardial pharmacokinetics.
Mass balance principles were used to study the myocardial pharmacokinetics of lignocaine in conscious sheep. After i.v. bolus doses of lignocaine 50, 75 or 100 mg, arterial lignocaine concentrations reached a peak in approximately 16 s and these increased linearly with dose. Coronary sinus concentrations reached a peak between 83 and 129 s and the values showed poor relationships with dose. Net myocardial lignocaine uptake lasted for approximately 60 s--this was much shorter than the reported initial distribution half-life of lignocaine. The maximum rate of uptake was proportional to both the dose and the peak arterial lignocaine concentrations. At 15 min, the myocardial lignocaine concentrations were 46 (SD 22)% of their peak values. Pseudo-equilibrium between blood and myocardial lignocaine concentrations was not observed. It is concluded that, despite the myocardium being very well perfused, lignocaine myocardial concentrations were not well represented by blood lignocaine concentrations for at least 15 min. A greater understanding of the determinants of myocardial drug concentrations is required.
Huang
Y F
YF
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, University of Adelaide, S.A., Australia.
Upton
R N
RN
Runciman
W B
WB
D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009206:Myocardium / Q000378:metabolism*; D012756:Sheep; D013997:Time Factors
D008012:Lidocaine