title: Hypothesis: cartilage catabolic cofactors in human arthritis.
abstract: Cartilage degradation in rheumatoid arthritis (RA) and osteoarthritis (OA) is commonly thought to be mediated by interleukin 1 (IL-1) and tumor necrosis factor (TNF). However, recent new evidence suggests that IL-1 and TNF on their own do not mediate all the cartilage changes seen in RA and OA. We propose that cartilage degradation is mediated by a complex network of cytokines, including IL-1, TNF and at least one cofactor present in synovial fluid.
authors: Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, PQ, Canada.
authors: A P
authors: AP
authors: Hollander
authors: P A
authors: PA
authors: Dieppe
authors: R M
authors: RM
authors: Atkins
authors: C J
authors: CJ
authors: Elson
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D010003:Osteoarthritis / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha