Persistent catheter-related bacteremia: clearance with antibiotics and urokinase.
A patient with terminal osteogenic sarcoma and catheter-related coagulase-negative staphylococcal bacteremia was treated with vancomycin and blood cultures were positive for 4 days documented with quantitative colony counts. Urokinase therapy was initiated and was associated with a transient bacteremia with markedly increased colony counts of coagulase-negative Staphylococcus prior to eradication of the catheter-related infection. We feel that the combination of urokinase and appropriate antibiotics may be an effective method to eradicate line-associated coagulase-negative staphylococcal infection in selected patients.
Ascher
D P
DP
Department of Pediatric Infectious Disease, Uniformed Services University of the Health Sciences, Bethesda, MD.
Shoupe
B A
BA
Maybee
D
D
Fischer
G W
GW
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000188:drug therapy* / Q000209:etiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012516:Osteosarcoma / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D014568:Urokinase-Type Plasminogen Activator