Ferrocins, new iron-containing peptide antibiotics produced by bacteria. Isolation, characterization and structure elucidation.
Novel iron-containing peptide antibiotics, ferrocins A, B, C and D, have been isolated from the culture filtrate of Pseudomonas fluorescens YK-310. These antibiotics were purified by butanol extraction, followed by column chromatography using adsorption resin, silica gel and preparative reverse-phase HPLC. The structures of ferrocins were elucidated using spectroscopic and degradative methods. Ferrocins contain three hydroxamate moieties per ferric ion which forms an octahedral iron complex.
Tsubotani
S
S
Discovery Research Laboratories II, Takeda Chemical Industries, Ltd., Osaka, Japan.
Katayama
N
N
Funabashi
Y
Y
Ono
H
H
Harada
S
S
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D005290:Ferric Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007501:Iron / Q000032:analysis; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011549:Pseudomonas / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D005290:Ferric Compounds; D010455:Peptides; D010456:Peptides, Cyclic; C079812:ferrocin A; C079813:ferrocin B; C079814:ferrocin C; C079815:ferrocin D; D007501:Iron