Treatment of malaria in Vietnam with oral artemisinin.
In this study, 638 patients with either Plasmodium falciparum or P. vivax malaria were treated with artemisinin (qinghaosu) that was isolated and formulated into tablets and capsules in Vietnam. In all cases, artemisinin treatment resulted in a rapid clearance of parasitemia and fever. Recrudescence rates were highest in those groups receiving treatment for five or less days (50%), but were between 10% and 23% for those groups receiving the drug for 5-10 days. A low recrudescent rate (9.5%) was also found when patients were treated with a combination of artemisinin for three days and tetracycline for five days. Thus, artemisinin represents a useful and economically feasible component of the malaria control program in Vietnam.
Nguyen
D S
DS
Institute of Malaria, Parasitology and Entomology, Hanoi, Vietnam.
Dao
B H
BH
Nguyen
P D
PD
Nguyen
V H
VH
Le
N B
NB
Mai
V S
VS
Meshnick
S R
SR
D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D037621:Artemisinins; D002214:Capsules; D002648:Child; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D016780:Malaria, Vivax / Q000188:drug therapy*; D012189:Retrospective Studies; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets; D014744:Vietnam
D000962:Antimalarials; D037621:Artemisinins; D002214:Capsules; D012717:Sesquiterpenes; D013607:Tablets; C031327:artemisinin