Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients.
OBJECTIVE
To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk.


METHODS
The study had a double-blind, cross-over design. Insulin sensitivity was measured with the euglycemic hyperinsulinemic glucose clamp technique at two different insulin infusion rates: 0.05 (clamp 1) and 0.10 U.kg-1.h-1 (clamp 2).


RESULTS
Subanalysis of the glucose infusion rate under steady-state conditions in the last 30 min of clamp 2 yielded a glucose infusion rate of 5.36 and 3.87 mmol.kg-1.min-1 after benfluorex and placebo, respectively (P = 0.018).


CONCLUSIONS
Benfluorex increases insulin sensitivity in obese type II diabetic patients.
Bianchi
R
R
Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.
Bongers
V
V
Bravenboer
B
B
Erkelens
D W
DW
D016632:Apolipoprotein A-I / Q000032:analysis; D001055:Apolipoproteins B / Q000097:blood; D001067:Appetite Depressants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015309:Glucose Clamp Technique; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity; D010919:Placebos; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D001067:Appetite Depressants; D001786:Blood Glucose; D002096:C-Peptide; D002784:Cholesterol; D005277:Fenfluramine; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; D010919:Placebos; D014280:Triglycerides; C001584:benfluorex