title: Basal and histamine-induced gastric acid secretion in alloxan diabetic rats.
abstract: 1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach.
authors: Department of Pharmacology, Faculty of Pharmacy, University of Ankara, Turkey.
authors: A T
authors: AT
authors: Ozçelikay
authors: V M
authors: VM
authors: Altan
authors: N
authors: N
authors: Yildizoğlu-Ari
authors: O
authors: O
authors: Altinkurt
authors: F
authors: F
authors: Onur
authors: Y
authors: Y
authors: Oztürk
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006632:Histamine