Pathogenic studies and antigenic and sequence comparisons of A/equine/Alaska/1/91 (H3N8) influenza virus.
An influenza virus, A/equine/Alaska/1/91 (H3N8), was isolated from horses from Alaska with an acute respiratory infection. Pathogenic and serologic studies revealed that this virus is similar to previously isolated equine H3N8 influenza viruses. Antigenic analyses utilizing hemagglutination inhibition and neuraminidase inhibition assays indicated an antigenic drift from the prototype equine H3N8 influenza virus, A/equine/Miami/1/63. Partial sequence analysis of the A/equine/Alaska influenza virus indicated that each of 8 gene sequences are of equine origin.
Alstad
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US Department of Agriculture, National Veterinary Services Laboratories, Ames, IA 50010.
Sahu
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Pedersen
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Saari
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Kawaoka
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Webster
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D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001717:Birds; D002642:Chick Embryo; D003429:Cross Reactions; D005289:Ferrets; D005814:Genes, Viral; D006386:Hemagglutination Tests; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses / Q000382:microbiology*; D053123:Influenza A Virus, H3N8 Subtype; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D009976:Orthomyxoviridae Infections / Q000382:microbiology / Q000662:veterinary*; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D013552:Swine
D000956:Antigens, Viral; D012367:RNA, Viral