title: Immaturity and chromosomal abnormalities in oocytes that fail to develop pronuclei following insemination in vitro.
abstract: A total of 293 oocytes that failed to develop pronuclei after insemination in vitro with apparently normal, fertile spermatozoa were obtained from 87 women undergoing therapeutic in-vitro fertilization. The oocytes were investigated cytogenetically to determine the incidence of immaturity and chromosomal abnormalities. Cytogenetic examination was possible in 81% of the preparations, in which immaturity and chromosomal abnormalities were present in 29.5 and 58.7% respectively.
authors: Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, Denmark Hill, London, UK.
authors: P A
authors: PA
authors: Almeida
authors: V N
authors: VN
authors: Bolton
mesh_terms: D002467:Cell Nucleus / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology; D002869:Chromosome Aberrations / Q000209:etiology*; D025063:Chromosome Disorders; D003593:Cytoplasm / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D015994:Incidence; D008297:Male; D009865:Oocytes / Q000166:cytology*; D011897:Random Allocation; D013094:Spermatozoa / Q000502:physiology