Interleukin-6 biosynthesis is increased by histamine in human B-cell and glioblastoma cell lines.
An enhancing effect of histamine on the biosynthesis and gene expression of interleukin-6 (IL-6) by human cell lines, Epstein-Barr virus (EBV)-infected human B lymphoma line BMNH and the glioblastoma line SK-MG4 has been found. No similar effect of histamine has been detected on the IL-6 production by any other B-cell line, CESS or human peripheral monocytes. Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine.
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Department of Molecular Biology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
D001254:Astrocytoma / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D006632:Histamine / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000276:immunology
D007075:Immunoglobulin M; D015850:Interleukin-6; D006632:Histamine