[A new skeletal muscle powered ventricle (SMPV) designed to work under physiologic preload].
To maximize pumping function the SMPV has been highly preloaded (over 30 mmHg); but the effects of pump size and configuration on the required preload have never been determined. A new double barrel dual chamber single layered (DCSL) SMPV having two SL small pumps in parallel was compared with a single chamber double layered small pump (SCDL). Stroke volume (SV) and stroke work (SW) were determined in acutely constructed SMPV using mongrel dog untrained latissimus dorsi: 10 DCSL and 12 SCDL. Under physiologic afterload (120 mmHg) and preload (15 mmHg), the DCSL displayed a significantly (p < 0.05) larger SV (9.9 +/- 1.2 ml) and SW (0.84 +/- 0.15 x 10(6) ergs) than the SCDL pumps (SV = 6.9 +/- 0.6 ml, and SW = 0.55 +/- 0.07 x 10(6) ergs). The DCSL pumps, requiring less muscle mass for its construction, indicated better performance under physiologic pre and afterload conditions than SCDL pumps.
Oda
T
T
Department of Cardiovascular Surgery, Kyoto University Faculty of Medicine, Japan.
Miyamoto
A
A
Okamoto
Y
Y
Ban
T
T
D000818:Animals; D002306:Cardiac Volume; D004285:Dogs; D005069:Evaluation Studies as Topic; D006321:Heart / Q000502:physiology*; D006353:Heart-Assist Devices / Q000592:standards*; D009200:Myocardial Contraction; D013318:Stroke Volume