title: [Acute lymphoblastic leukemia: comparison of traditional treatment with intensive therapy methods].
abstract: In this study we compare two different therapies for the treatment of non-B acute lymphoblastic leukemia (ALL). Forty-four children diagnosed as having non-B ALL were treated by one of two methods: 20 children were treated from 1981 to 1984 according to the PETHEMA 7/78 protocol and 24 children were treated from 1984 to 1987 following the BFM 83 protocol. These treatments differ in that BFM 83 includes a higher number of cytostatics, uses intravenous methotrexate at moderate doses as "reservoirs" treatment and a lower dose of holocranial radiotherapy. The BFM 83 treatment resulted in a significant improvement in survival (48% versus 92% p < 0.05), as well as in the absence of further events (45% versus 88%, p < 0.01).
authors: Departamento de Pediatría, Hospital 12 de Octubre, Madrid.
authors: J L
authors: JL
authors: Vivanco Martínez
authors: A
authors: A
authors: López Panero
authors: C
authors: C
authors: Melero Moreno
authors: J
authors: J
authors: López Pérez
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D013030:Spain; D016896:Treatment Outcome
vernacular_title: Leucemia linfoblástica aguda: comparación de los resultados del tratamiento clásico con terapias intensivas.