Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes.
Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.
Tanaka
Y
Y
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Adams
D H
DH
Shaw
S
S
D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000378:metabolism; D008954:Models, Biological; D011509:Proteoglycans / Q000502:physiology*; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism; D015398:Signal Transduction
D016207:Cytokines; D006025:Glycosaminoglycans; D011509:Proteoglycans; D016201:Receptors, Lymphocyte Homing