Familial cases of gastroschisis in a population-based registry.
Only a few familial cases of gastroschisis have been reported. Consequently, the risk of a recurrence has been thought to be very small. In a population-based study of gastroschisis that included an extended pedigree of all probands, 6 (4.7%) out of 127 families had more than one affected relative. The relationships of the affected were: sib, half-sib (2), first cousin, second cousin once removed, and great uncle. Sib recurrence was 3.5%. Our results suggest that pregnancies occurring in a family with a history of gastroschisis may be at higher risk of recurrence than previously thought.
Torfs
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CP
California Birth Defects Monitoring Program, Emeryville 94608.
Curry
C J
CJ
D000009:Abdominal Muscles / Q000002:abnormalities*; D000328:Adult; D002648:Child; D004065:Digestive System Abnormalities; D005260:Female; D005828:Genetics, Population; D006801:Humans; D007223:Infant; D008297:Male; D008423:Maternal Age; D010375:Pedigree; D011247:Pregnancy; D012042:Registries; D012307:Risk Factors