Ketoconazole administration in hypercortisolemic depression.
Ketoconazole, an antiglucocorticoid drug, was administered to 10 hypercortisolemic depressed patients for up to 6 weeks. Three patients dropped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cortisol levels and in depression ratings. Antiglucocorticoid agents may be useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.
Wolkowitz
O M
OM
Department of Psychiatry, University of California, San Francisco.
Reus
V I
VI
Manfredi
F
F
Ingbar
J
J
Brizendine
L
L
Weingartner
H
H
D000328:Adult; D000368:Aged; D003864:Depression, Chemical; D003866:Depressive Disorder / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000502:physiology; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index
D007654:Ketoconazole; D006854:Hydrocortisone