Magnetic resonance and the diagnosis of short stature of hypothalamic-hypophyseal origin.
Magnetic resonance imaging was performed in 23 patients with short stature (7 had multiple pituitary hormone defect, 11 had isolated growth hormone deficiency and 5 had normal variant short stature) to investigate if there is a relation between magnetic resonance findings and results of endocrine tests. Magnetic resonance imaging of patients with multiple pituitary hormone deficiency or with serious isolated growth hormone deficiency (growth hormone < 3 micrograms/l) revealed an interrupted pituitary stalk and ectopic neurohypophysis or a mass. In patients with less serious isolated growth hormone deficiency (growth hormone > 3 micrograms/l) or with normal variant short stature, the technique revealed a normal or hypoplastic hypophysis. Magnetic resonance appears to be a useful second-level diagnostic tool in defining the type of alteration in growth defects of endocrine origin.
Vannelli
S
S
Centro di Auxopatologia, Università di Torino, Italy.
Avataneo
T
T
Benso
L
L
Potenzoni
F
F
Cirillo
S
S
Mostert
M
M
Bona
G
G
D000293:Adolescent; D001827:Body Height; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000175:diagnosis* / Q000503:physiopathology; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis* / Q000503:physiopathology; D007031:Hypothalamus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010900:Pituitary Diseases / Q000175:diagnosis* / Q000503:physiopathology; D010902:Pituitary Gland / Q000473:pathology; D010907:Pituitary Hormones / Q000172:deficiency
D010907:Pituitary Hormones; D013006:Growth Hormone