Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts.
Mutagenic and antimutagenic activities of extracts and chromatographic fractions of Uncaria tomentosa bark are reported. The plant extracts and fractions show no mutagenic effect in different strains of Salmonella typhimurium with and without metabolic activation. However, the plant extracts and fractions show a protective antimutagenic effect in vitro against photomutagenesis induced by 8-methoxy-psoralen (8-MOP) plus UVA in S. typhimurium TA 102. A decoction of U. tomentosa ingested daily for 15 days by a smoker decreased the mutagenicity induced in S. typhimurium TA98 and TA100 by the subject's urine.
Rizzi
R
R
Departmento di Farmacologia, Chemioterapia e Tossicologia Medica, Università degli Studi di Milano, Italy.
Re
F
F
Bianchi
A
A
De Feo
V
V
de Simone
F
F
Bianchi
L
L
Stivala
L A
LA
D000328:Adult; D000818:Animals; D016587:Antimutagenic Agents / Q000378:metabolism / Q000494:pharmacology*; D002725:Chloroform / Q000737:chemistry; D006801:Humans; D008297:Male; D000432:Methanol / Q000737:chemistry; D008730:Methoxsalen; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity / Q000652:urine; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000528:radiation effects; D012907:Smoking / Q000652:urine; D012995:Solubility; D014466:Ultraviolet Rays
D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts; D002725:Chloroform; D008730:Methoxsalen; D000432:Methanol