[The effect of x-ray irradiation on the production of interleukin-6 and tumor necrosis factor-alpha by mononuclear cells of the peripheral blood].
The influence of X-radiation on production of interleukin-6 (IL-6) and alpha-tumor necrosis factor (TNF) has been investigated. Irradiation with doses of 45, 90 and 900 cGy was shown to increase considerably TNF and IL-6 production both in intact mononuclear cultures of human peripheral blood and in cultures stimulated by phytohemagglutinin. In addition to an absolute increase in the production, the stimulatory effect was manifested by earlier accumulation of IL-6 and TNF activities in supernatant fractions of the cultures under study.
Komarovskaia
M E
ME
Dryk
S I
SI
Krivenko
S I
SI
Karkanitsa
L V
LV
D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000096:biosynthesis / Q000528:radiation effects*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects*
D015850:Interleukin-6; D010835:Phytohemagglutinins; D014409:Tumor Necrosis Factor-alpha
Vliianie rentgenovskogo oblucheniia na produktsiiu interleĭkina-6 i faktor nekroza opukholeĭ-al'fa mononuklearami perifericheskoĭ krovi.