title: Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.
abstract: Antifungal activity of three nagilactones isolated from the root bark of Podocarpus nagi (Podocarpaceae), alone and in combination with a variety of phenylpropanoids, was investigated against three fungi, Candida albicans, Saccharomyces cerevisiae, and Pityrosporum ovale. Nagilactone E [2], the most abundant norditerpene dilactone, showed moderate to weak activity against these fungi. This activity was dramatically enhanced by several naturally occurring phenylpropanoids such as anethole [5] and isosafrole. For example, anethole enhanced the activity of nagilactone E as much as 128-fold for C. albicans, decreasing the MIC of this nagilactone from 800 to 6.25 micrograms/ml.
authors: Division of Entomology and Parasitology, College of Natural Resources, University of California, Berkeley 94720.
authors: I
authors: I
authors: Kubo
authors: H
authors: H
authors: Muroi
authors: M
authors: M
authors: Himejima
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000840:Anisoles / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D003470:Culture Media; D004224:Diterpenes / Q000494:pharmacology*; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
chemical_list: D000840:Anisoles; D000935:Antifungal Agents; D003470:Culture Media; D004224:Diterpenes; C004552:nagilactone C; D000666:Amphotericin B