Antihypertensive effect of the calcium antagonist isradipine and lipid profile.
The hypothesis that plasma lipids may modulate the antihypertensive effect of the calcium antagonist isradipine was tested in 85 patients who had essential hypertension. Significant linear correlations were found between the antihypertensive effect of isradipine and plasma levels of total cholesterol and high-density lipoprotein (HDL2 or HDL3) in normotriglyceridemic (n = 63), but not in hypertriglyceridemic (n = 22), patients. From this, we conclude that normal levels of plasma lipids may modulate the function of calcium channels and their interaction with calcium antagonists.
Farsang
C
C
First Department of Medicine, St. Emeric Teaching Hospital, Budapest, Hungary.
Kiss
I
I
Kapocsi
J
J
Török
E
E
Maklári
E
E
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D017275:Isradipine / Q000494:pharmacology / Q000627:therapeutic use*; D016014:Linear Models; D008875:Middle Aged; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D002784:Cholesterol; D017275:Isradipine