The effect of cyclosporin A on rabbit nephrotoxic glomerulonephritis.
The effect of cyclosporin A on the development of the autologous phase of experimental rabbit glomerulonephritis was assessed. The glomerulonephritis was induced by a single intravenous injection of duck anti-rabbit glomerular basement membrane globulin (molecular weight: 115 kDa) into adult rabbits. After 5-7 days, diffuse proliferative glomerulonephritis with proteinuria was observed in all the animals not treated with cyclosporin A (control group). The cyclosporin A treatment was started simultaneously with the injection of duck globulin. This attenuated the glomerular lesion, resulting in a normal urinary protein excretion. The serum level of autologous anti-duck IgG was reduced. In the group of rabbits which received an injection of duck anti-rabbit glomerular basement membrane globulin, cyclosporin A treatment and an additional high dose rabbit anti-duck globulin 8 days later again no glomerulonephritis was observed. However, cyclosporin A treatment had no effect on the observed duck immunoglobulin-induced passive Arthus phenomenon.
Kurunczi
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S
St Josef-Hospital, Children's Hospital of University Bochum, Germany.
Mark
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I
D000818:Animals; D001327:Autoimmune Diseases / Q000473:pathology / Q000517:prevention & control*; D001485:Basement Membrane / Q000276:immunology; D002455:Cell Division; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000473:pathology / Q000517:prevention & control*; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D011507:Proteinuria / Q000517:prevention & control; D011817:Rabbits
D016572:Cyclosporine