[Diffuse idiopathic skeletal hyperostosis (DISH) and pseudo-coxarthritis following long-term etretinate therapy].
A 51-year old patient with congenital basal cell naevus syndrome was treated with etretinate (50-100 mg/daily) over a period of 5 years (cumulative dose 110 g). Clinically he developed a stiff back with pronounced disability of both hips. Radiologically, axial involvement of the spine with severe diffuse idiopathic skeletal hyperostosis especially of the lumbar spine, and ossifications of both hips were documented. Rheumatological implications of long-term therapy with etretinate are discussed.
Theiler
R
R
Universitätsspital Zürich, Rheumaklinik.
Hübscher
E
E
Wagenhäuser
F J
FJ
Panizzon
R
R
Michel
B
B
D001478:Basal Cell Nevus Syndrome / Q000188:drug therapy; D005050:Etretinate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D013997:Time Factors
D005050:Etretinate
Diffuse idiopathische skelettale Hyperostose (DISH) und Pseudocoxarthrose nach Langzeit-Etretinat-Therapie.