Treatment of mixed Oesophagostomum and hookworm infection: effect of albendazole, pyrantel pamoate, levamisole and thiabendazole.
Oesophagostomum bifurcum has recently been recognized as a common parasite of man in northern Togo and in Ghana. In a preliminary trial several anthelmintics were evaluated in the treatment of mixed Oesophagostomum and hookworm infections. Diagnosis was based on faecal culture, since the eggs of Oesophagostomum and hookworm cannot be distinguished morphologically. Of the anthelmintics tested, albendazole was most effective against both parasites. Pyrantel pamoate, 2 x 10 mg/kg, was effective against Oesophagostomum but not against hookworm. The cure rates for both parasites were moderate with thiabendazole and poor with levamisole.
Krepel
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Ministry of Health, Dapaong, Togo.
Haring
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Baeta
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Polderman
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AM
D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000469:parasitology; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy* / Q000469:parasitology; D006801:Humans; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D009814:Oesophagostomiasis / Q000188:drug therapy* / Q000469:parasitology; D010270:Parasite Egg Count; D011716:Pyrantel Pamoate / Q000627:therapeutic use*; D013827:Thiabendazole / Q000627:therapeutic use*; D014037:Togo; D016896:Treatment Outcome
D007978:Levamisole; D011716:Pyrantel Pamoate; D015766:Albendazole; D013827:Thiabendazole