title: [Synthesis of thiazolo[3,2-a]pyridine derivatives and their reactions].
abstract: By the reaction of 2-benzoylmethyl-4-methylthiazole (6) with polarized olefins (3, 4) in the presence of base (K2CO3 or NaH), the corresponding thiazolo[3,2-a]pyridine derivatives (7, 8) were obtained. Methylsulfinylthiazolopyridine derivative (11) obtained by the reaction of 8b with m-chloroperbenzoic acid (MCPBA), easily underwent nucleophilic substitution to give the corresponding substituted compounds (10, 12).
authors: School of Pharmaceutical Sciences, Nagasaki University, Japan.
authors: Y
authors: Y
authors: Matsuda
authors: H
authors: H
authors: Matsumoto
authors: S
authors: S
authors: Ide
authors: K
authors: K
authors: Furuno
authors: K
authors: K
authors: Torisu
authors: T
authors: T
authors: Itou
authors: C
authors: C
authors: Motokawa
mesh_terms: D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011725:Pyridines; D014230:Triazoles