title: Genetically determined body weight loss in mice fed diets containing salmon oil.
abstract: Several reports describe adverse effects of dietary fish oil. We examined the influence of dietary salmon oil (138 g/kg diet) fed without or with 5 g supplemental cholesterol/kg diet on body weight and plasma lipid concentrations of inbred mice. Salmon oil contained 0.17 g naturally occurring cholesterol/kg diet. Mice used were BALB/c, C57BL/6 and seven recombinant inbred strains derived from BALB/c and C57BL/6 (CXB). Parental strains BALB/c and C57BL/6 maintained or gained body weight when fed both salmon oil diets. Mice of recombinant inbred strains showed weight gain except for CXB-E and -H mice. Although CXB-E mice lost approximately 12% of initial body weight after 10 d of consuming either salmon oil diet, no further reductions in body weight were seen. CXB-H mice maintained or gained weight when fed the salmon oil-high cholesterol diet but showed a steady decline in body weight (up to 30% of initial weight) while consuming the salmon oil-low cholesterol diet. The biochemical basis for weight loss in CXB-H mice was studied and results suggest effects of diet on satiety and/or lipid utilization. Because nonparental body weight phenotypes were observed among recombinant inbred strains, body weight response to salmon oil feeding is controlled by multiple genes.
authors: Department of Medicine, University of Washington, Seattle 98195.
authors: R C
authors: RC
authors: LeBoeuf
authors: M S
authors: MS
authors: Veldee
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004435:Eating; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000009:adverse effects; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012450:Safflower Oil / Q000008:administration & dosage; D015431:Weight Loss / Q000235:genetics*
chemical_list: D002791:Cholesterol, Dietary; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils; D008055:Lipids; C030341:salmon oil; D012450:Safflower Oil; D002784:Cholesterol