title: Primary and secondary microcirculatory disorders in essential hypertension.
abstract: In this prospective cross-sectional study blood fluidity and peripheral microcirculation were measured in patients suffering from essential hypertension with and without macroangiopathy. The cutaneous microcirculation was evaluated by intravital microscopy and the intramuscular by pO2 needle electrode. Disorders in the microcirculation without macroangiopathy in the system of the feeding arteries are defined as primary microangiopathy. Disturbed microcirculation with macroangiopathy in the feeding arteries in one area but no detectable microcirculatory disorder in another region is defined as a secondary microcirculatory disorder. Of the 57 patients in this study 27 had a primary microcirculatory disorder. It was remarkable that all 27 hypertension patients had a microcirculatory disorder in the area of the skin. Intramuscular microcirculatory disorder on its own without affection of the skin was not detected in any case. An exclusively secondary microcirculatory disorder occurred in 16 patients. This study shows that 93% of the patients with long-term essential arterial hypertension have microcirculatory disorders. It is most interesting that about one-half of these hypertension patients had a primary microcirculatory disorder, i.e., no indication of a hemodynamically active stenosis was found in the large vessels.
authors: Abteilung für Klinische Hämostaseologie und Transfusionsmedizin, Universität des Saarlandes, Homburg-Saar.
authors: F
authors: F
authors: Jung
authors: W
authors: W
authors: Kolepke
authors: S
authors: S
authors: Spitzer
authors: H
authors: H
authors: Kiesewetter
authors: K W
authors: KW
authors: Ruprecht
authors: R
authors: R
authors: Bach
authors: H
authors: H
authors: Schieffer
authors: E
authors: E
authors: Wenzel
mesh_terms: D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000150:complications; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply*; D009262:Nails / Q000098:blood supply; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012867:Skin / Q000098:blood supply*; D014741:Video Recording
chemical_list: D010100:Oxygen