Cutaneous leishmaniasis in mast cell-deficient W/Wv mice.
Genetically mast cell-deficient W/Wv mice infected with Leishmania amazonensis showed progressive development of ulcerative skin lesions. However, no significant differences between the W/Wv mice and the normal littermates with respect to size of the lesions, anti-Leishmania immunoglobulin E antibody, and the number of eosinophils accumulated in the lesions were observed.
Katakura
K
K
Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan.
Saito
S
S
Hamada
A
A
Matsuda
H
H
Watanabe
N
N
D000818:Animals; D004804:Eosinophils / Q000276:immunology; D005260:Female; D007891:Leishmania / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology* / Q000473:pathology; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D012867:Skin / Q000276:immunology / Q000473:pathology