title: [Experimental studies on the development of residual stomach cancer--comparison of Billroth I and Billroth II].
abstract: The effects of duodenogastric reflex on the development of residual stomach cancer and cell proliferation kinetics were investigated in Wistar rats. Billroth II resection (B-II group) was performed on 24 rats and Billroth I resection (B-I group) was performed on 22 rats. The incidence of cancer in the B-II group was 20.8%, though no cancer was noted in the B-I group. The incidences of the pseudopyloric gland, dilated gland and gastritis cystica profunda in the B-II group were significantly higher than those in the B-I group. The degree of mucosal atrophy was greater in the B-II group than in the B-I group. The stomal area in the B-II group had expansion of proliferative zone as well as increased S-phase duration and turn over time, compared with those in the B-I group. The sequence of histological and proliferative events associated with duodenogastric reflux suggests that the residual stomach in the B-II group is susceptible to the development of cancer.
authors: Second Department of Surgery, Kanazawa University School of Medicine, Japan.
authors: T
authors: T
authors: Kamata
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004383:Duodenogastric Reflux / Q000209:etiology; D005743:Gastrectomy / Q000379:methods*; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery