title: Effect of running training on uncoupling protein mRNA expression in rat brown adipose tissue.
abstract: The effect was investigated of endurance training on the expression of uncoupling protein (UCP) mRNA in brown adipose tissue (BAT) of rats. The exercised rats were trained on a rodent treadmill for 5 days per week and a total of 9 weeks. After the training programme, a marked decrease in BAT mass was found in terms of weight or weight per unit body weight; there was a corresponding decrease in DNA content and a downward trend in RNA and glycogen levels. The UCP mRNA was present at a markedly decreased level in BAT of trained animals. In consideration of the reduced levels of mRNAs for hormone-sensitive lipase and acyl-CoA synthetase, the brown adipose tissue investigated appeared to be in a relatively atrophied and thermogenically quiescent state.
authors: Department of Hygiene, National Defense Medical College, Tokorozawa, Japan.
authors: H
authors: H
authors: Yamashita
authors: M
authors: M
authors: Yamamoto
authors: Y
authors: Y
authors: Sato
authors: T
authors: T
authors: Izawa
authors: T
authors: T
authors: Komabayashi
authors: D
authors: D
authors: Saito
authors: H
authors: H
authors: Ohno
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D015870:Gene Expression; D007473:Ion Channels; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D024101:Mitochondrial Proteins; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D012420:Running; D014475:Uncoupling Agents / Q000378:metabolism; D000071256:Uncoupling Protein 1
chemical_list: D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1