Analysis of multivariate parallel-line bioassay with composite responses and composite doses, using canonical correlations.
The use of a composite response to estimate the relative potency in a multivariate parallel-line bioassay is described by Finney. Occasionally a multivariate bioassay has multiple drugs also. Such a situation arises, for example, when a treatment contains several drugs. A procedure for combining multiple responses and combining multiple drugs is proposed in this paper, in order to obtain point and interval estimates of the relative potency. A composite response and a composite dose level for this purpose are obtained by using canonical analysis.
Yuan
W
W
Department of Biostatistics, University of Michigan, Ann Arbor.
Kshirsagar
A M
AM
D001681:Biological Assay / Q000379:methods / Q000706:statistics & numerical data*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D008432:Mathematical Computing; D015999:Multivariate Analysis; D010600:Pharmacology / Q000379:methods / Q000706:statistics & numerical data*