title: Localization of E-cadherin adhesion molecules in human gingiva and gingival carcinoma.
abstract: Immunohistochemical investigations were carried out on the localization and expression of the Ca(2+)-dependent intercellular adhesion molecule E-cadherin in human gingiva and gingival carcinoma. Although E-cadherin did not appear in the parakeratinized layer of either clinically healthy or inflamed gingiva, it did appear strongly in the prickle layer and somewhat more weakly in the basal layer. Immunogold particles reactive to anti-E-cadherin monoclonal antibody in the electron microscopic findings were localized only in the vicinity of the desmosomes of the prickle and basal layers. In the case of gingival carcinoma, although E-cadherin was strongly expressed in the cells surrounding the keratinized region in the cancer nests, the expression decreased towards the marginal portion of the cancer nests. The distribution of E-cadherin in these cells may be dependent on the condition of the cancer cells that are potentially invasive. These findings suggest that cells of the parakeratinized layer of gingiva and cells of the marginal portion of the gingival carcinoma nests may easily detach or invade. In addition, the findings suggest that the gingival carcinoma used in this study tended to be invasive.
authors: First Department of Oral and Maxillofacial Surgery, Osaka Dental University, Japan.
authors: T
authors: T
authors: Sakaki
authors: M
authors: M
authors: Wato
authors: S
authors: S
authors: Otake
authors: R
authors: R
authors: Shirasu
authors: A
authors: A
authors: Tanaka
mesh_terms: D000368:Aged; D015820:Cadherins / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D005260:Female; D005881:Gingiva / Q000737:chemistry* / Q000166:cytology; D005887:Gingival Neoplasms / Q000737:chemistry*; D006801:Humans; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D010518:Periodontitis
chemical_list: D015820:Cadherins