Association of glyceraldehyde-3-phosphate dehydrogenase expression with cell motility and metastatic potential of rat prostatic adenocarcinoma.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increased in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correlates with cell motility of Dunning prostate cancer cell lines and accurately distinguishes cell lines with high metastatic potential from those with low metastatic potential. Increased GAPDH expression in the cancer cell lines is not simply related to increased growth rate, since rapidly proliferating normal prostate tissue did not exhibit elevated GAPDH expression.
Epner
D E
DE
Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
Partin
A W
AW
Schalken
J A
JA
Isaacs
J T
JT
Coffey
D S
DS
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D002465:Cell Movement; D015870:Gene Expression; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics*; D066298:In Vitro Techniques; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases