Psychosis following readministration of diethyl proprion: a possible role for kindling?
The case of an organic psychosis following the readministration of an amphetamine-like anorexiant is described. Previous therapeutic use of the same drug 2 years earlier was without adverse effect. Similar phenomena have been reported with other drugs, and both behavioural sensitization and kindling are possible explanations. The latter, however, provides a parsimonious explanation, a therapeutic rationale, and brings together seemingly disparate laboratory and clinical phenomena.
Little
J D
JD
Department of Psychological Medicine, Dunedin Hospital, New Zealand.
Romans
S E
SE
D004053:Diethylpropion / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007696:Kindling, Neurologic; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000209:etiology* / Q000503:physiopathology
D004053:Diethylpropion