title: [Medulloblastomas--the results after postoperative radiotherapy with and without adjuvant chemotherapy].
abstract: Between 1975 and 1991, 40 patients with newly diagnosed medulloblastoma were treated at the authors' institutions. After aggressive surgical resection 39/40 (98%) received craniospinal radiation therapy with a local boost to the posterior fossa and other macroscopically involved areas. A group of 29 patients was treated with adjuvant chemotherapy. The five-year actuarial survival and event-free survival were 75% and 65%, respectively. Survival was significantly better for patients treated after 1981 as compared to those treated between 1975 and 1980 (p = .02). Younger age (two to four years) was associated with a better prognosis (p = .02). The extend of resection, Chang-stage, radiation dose to posterior fossa and the use of chemotherapy did not significantly impact on survival and relapse-free survival.
authors: Strahlentherapeutische Klinik, Universität Erlangen-Nürnberg.
authors: G G
authors: GG
authors: Grabenbauer
authors: C
authors: C
authors: Löhnert
authors: J
authors: J
authors: Erhardt
authors: M
authors: M
authors: Buchfelder
authors: U
authors: U
authors: Neubauer
authors: J D
authors: JD
authors: Beck
authors: S
authors: S
authors: Reitz
authors: H
authors: H
authors: Seyer
authors: P
authors: P
authors: Thierauf
authors: R
authors: R
authors: Fietkau
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002528:Cerebellar Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005860:Germany, West; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D002955:Leucovorin / Q000008:administration & dosage; D008130:Lomustine / Q000008:administration & dosage; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D008727:Methotrexate / Q000008:administration & dosage; D011182:Postoperative Care / Q000379:methods*; D011344:Procarbazine / Q000008:administration & dosage; D011379:Prognosis; D011879:Radiotherapy Dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D014750:Vincristine; D008130:Lomustine; D003520:Cyclophosphamide; D002955:Leucovorin; D007069:Ifosfamide; D008727:Methotrexate
vernacular_title: Medulloblastome--Ergebnisse nach postoperativer Radiotherapie mit und ohne adjuvante Chemotherapie.