Production and regulation of gelatinase B by human T-cells.
Here we describe for the first time the production of gelatinase B (MMP 9; 92-kDa type IV collagenase) by human peripheral blood T-lymphocytes. Expression of this enzyme was found to be dependent on the activation status of these T-cells and to be regulated by Interleukin-2.
Montgomery
A M
AM
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
Sabzevari
H
H
Reisfeld
R A
RA
D002469:Cell Separation; D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000235:genetics* / Q000378:metabolism; D017077:Culture Media, Conditioned / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation; D020780:Matrix Metalloproteinase 9; D010641:Phenotype; D013601:T-Lymphocytes / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism
D017077:Culture Media, Conditioned; D007376:Interleukin-2; D003094:Collagen; D017364:Collagenases; D020780:Matrix Metalloproteinase 9