The sensitizing potency of Euxyl K 400 and its components 1,2-dibromo-2,4-dicyanobutane and 2-phenoxyethanol.
Using a modified FCA (Freund's complete adjuvant) procedure, the sensitizing capacity of Euxyl K 400 and its ingredients, 1,2-dibromo-2,4-dicyanobutane and 2-phenoxyethanol, has been studied in guinea pigs. The experiments demonstrate that a distinct but weak sensitizing potency exists for Euxyl K 400 and dibromodicyanobutane. Phenoxyethanol remained almost negative. These results are in good accordance with the low number of cases of allergic contact dermatitis due to Euxyl K 400 and dibromodicyanobutane described since their introduction on the market. Cases of phenoxyethanol contact allergy have been published hitherto only 4x in the medical literature.
Hausen
B M
BM
Department of Dermatology, University Hospital, Hamburg, Germany.
D000485:Allergens / Q000009:adverse effects / Q000032:analysis / Q000276:immunology; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000032:analysis / Q000276:immunology; D017453:Dermatitis, Irritant / Q000276:immunology*; D005026:Ethylene Glycols / Q000009:adverse effects / Q000032:analysis / Q000737:chemistry / Q000276:immunology*; D006168:Guinea Pigs; D009570:Nitriles / Q000009:adverse effects / Q000032:analysis / Q000737:chemistry / Q000276:immunology*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects* / Q000737:chemistry
D000485:Allergens; D000891:Anti-Infective Agents, Local; D005026:Ethylene Glycols; D009570:Nitriles; D011310:Preservatives, Pharmaceutical; C005398:phenoxyethanol; C039411:1,2-dibromo-2,4-dicyanobutane