title: Ileo-caecal ulceration associated with the use of diclofenac slow release.
abstract: A 38-year-old man with seropositive arthropathy on long-standing treatment with diclofenac slow release presented with abdominal pain, diarrhoea and anaemia. Upper gastrointestinal endoscopy and barium series were unremarkable. Five months later he presented with a right iliac fossa mass. Investigations revealed discrete ulceration in the terminal ileum and caecum confirmed at laparotomy. Other possible causes of intestinal ulceration were excluded suggesting a diagnosis of non-steroidal anti-inflammatory drug associated intestinal ulceration.
authors: Department of Therapeutics, University Hospital, Queen's Medical Centre, Nottingham, UK.
authors: N
authors: N
authors: Hudson
authors: M J
authors: MJ
authors: Wilkinson
authors: A J
authors: AJ
authors: Swannell
authors: R J
authors: RJ
authors: Steele
authors: C J
authors: CJ
authors: Hawkey
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D007592:Joint Diseases / Q000188:drug therapy; D008297:Male; D014456:Ulcer / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D003692:Delayed-Action Preparations; D004008:Diclofenac