title: Reverse mismatch between perfusion and aerosol ventilation in transplanted lungs.
abstract: Thirty ventilation-perfusion pulmonary scintigraphic studies were performed in 13 patients who had undergone unilateral lung transplantation. Ventilation-perfusion mismatch (ventilation better than perfusion) was judged absent, mild, moderate, or severe in the transplanted and native lungs. Ventilation-perfusion mismatch was significantly worse in the transplanted lungs (p < .0001). Findings of lung biopsies and chest roentgenograms failed to correlate with the severity of ventilation-perfusion mismatch. Hypoxic pulmonary vasoconstriction appears to be significantly impaired in most unilateral lung transplants; the mechanism for this impairment is unclear.
authors: Department of Radiology, University of Minnesota Hospital and Clinic, Minneapolis 55455.
authors: C C
authors: CC
authors: Kuni
authors: R P
authors: RP
authors: Ducret
authors: R E
authors: RE
authors: Nakhleh
authors: R J
authors: RJ
authors: Boudreau
mesh_terms: D000328:Adult; D000336:Aerosols; D001706:Biopsy; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology / Q000502:physiology; D016040:Lung Transplantation / Q000000981:diagnostic imaging* / Q000473:pathology / Q000502:physiology; D008297:Male; D011667:Pulmonary Veins / Q000503:physiopathology; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D016284:Technetium Tc 99m Pentetate; D014661:Vasoconstriction / Q000502:physiology; D014692:Ventilation-Perfusion Ratio / Q000502:physiology
chemical_list: D000336:Aerosols; D016284:Technetium Tc 99m Pentetate