MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis.
Glutaminergic and cholinergic neuronal interactions were investigated by using the brain microdialysis method in freely-moving rats. Acute administration of (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5, 10-imine hydrogen maleate (MK-801) increased dose-dependently the extracellular acetylcholine (ACh) level in the rat parietal cortex. Significant increases in the extracellular ACh level were observed at doses of 0.4 and 0.5 mg/kg of MK-801, compared with the saline-treated group. The increase of extracellular ACh level was eliminated by infusion of 10(-2) M N-methyl-D-aspartate (NMDA). These results suggest that the glutaminergic neuronal system regulates functions of the cholinergic neuronal system.
Hasegawa
M
M
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Kinoshita
H
H
Amano
M
M
Hasegawa
T
T
Kameyama
T
T
Nabeshima
T
T
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D003956:Dialysis / Q000379:methods; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005110:Extracellular Space / Q000378:metabolism; D007700:Kinetics; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D000109:Acetylcholine