Variation in left ventricular regional wall stress with cine magnetic resonance imaging: normal subjects versus dilated cardiomyopathy.
We measured the variation of end-systolic wall stress and its relation to regional ejection fraction in short-axis planes through the left ventricle in normal subjects and in patients with dilated cardiomyopathy (DCM) by cine magnetic resonance imaging. There was a gradual increase in end-systolic wall stress but a gradual decrease in ejection fraction from apex to base in normal subjects (14 +/- 6 to 52 +/- 15 kdyne/cm2, 78% +/- 12% to 62% +/- 8%) and in patients with DCM (49 +/- 28 to 130 +/- 30 kdyne/cm2, 40 +/- 18 to 23% +/- 9%). The end-systolic wall stress in patients with DCM was higher than in normal subjects at every level (p < 0.01). We conclude that there is a variation in end-systolic wall stress in both normal subjects and patients with DCM with regional ejection fraction inversely related to regional end-systolic wall stress.
Fujita
N
N
Department of Radiology, University of California, San Francisco 94143-0628.
Duerinekx
A J
AJ
Higgins
C B
CB
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000473:pathology* / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D013314:Stress, Mechanical; D013318:Stroke Volume; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*