Quantification of prostaglandin E1 receptors in cavernous tissue of men, monkeys and dogs.
Prostaglandin E1 (PGE1) has been shown to relax the muscles of the corpora cavernosa and inhibit spontaneous activity, and clinical trials have proved its safety and effectiveness when given intracavernously to induce erection. Through use of a specific PGE1 receptor binding assay, we undertook this study to quantify its receptor density and measure binding affinity. The cavernous tissue of normal and impotent men as well as that of monkeys and dogs was studied in an attempt to understand their different responses to the intracavernous injection of PGE1. Our results showed a lower receptor density in impotent men than in normal men and monkeys and a complete absence of receptors in dogs. These findings correlated well with the clinical response to intracavernous injection of PGE1.
Aboseif
S
S
Department of Urology, University of California School of Medicine, San Francisco 94143-9738.
Riemer
R K
RK
Stackl
W
W
Lue
T
T
Tanagho
E
E
D000527:Alprostadil / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D004285:Dogs; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000378:metabolism; D000882:Haplorhini; D006801:Humans; D007267:Injections; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D011869:Radioligand Assay; D011982:Receptors, Prostaglandin / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism
D011982:Receptors, Prostaglandin; D000527:Alprostadil