title: [Local immune response in neurofibromatosis type 1 and type 2].
abstract: Neurofibromatosis, in all its variant forms, is a hereditary disease characterized by dysplasia, neoplasia, and the tendency to expand and undergo malignant transformation. We underline the presence of chronic inflammation and of immunologic interdependency. The immune reactions against the non-self have been investigated histologically in light of the concepts of immunosurveillance and immunotolerance. Such investigations would ameliorate subsequent studies and favour the employment of immunomodulatory treatments.
authors: Reparto Ortopedia e Traumatologia II, Ospedale Niguarda, Milano.
authors: P L
authors: PL
authors: Gerosa
authors: C
authors: C
authors: Vai
authors: L
authors: L
authors: Bizzozero
authors: A
authors: A
authors: Fontana
authors: G
authors: G
authors: Giussani
authors: M
authors: M
authors: Spinelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016518:Neurofibromatosis 2 / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009418:S100 Proteins
vernacular_title: L'immunoreazione locale nelle neurofibromatosi di von Recklinghausen e del neurinoma bilaterale del nervo acustico.