Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2-receptor antagonists.
In a randomised placebo controlled study, two groups of six maturity onset diabetic patients stabilised on glipizide were given cimetidine (400 mg) or ranitidine (150 mg) 3 h before a standardised meal. In comparison with placebo, both cimetidine and ranitidine significantly reduced the post-prandial rise in blood glucose by a mean of 40% and 25% respectively producing glucose levels of less than 3 mmol l-1 (lowest 1.5 mmol l-1) in four patients. Both drugs also significantly increased plasma glipizide AUC by approximately 20%. Caution should be exercised when initiating treatment with H2-receptor antagonists in diabetics receiving sulphonylurea hypoglycaemic agents.
Feely
J
J
Department of Therapeutics, Trinity College, Dublin.
Collins
W C
WC
Cullen
M
M
el Debani
A H
AH
MacWalter
R S
RS
Peden
N R
NR
Stevenson
I H
IH
D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D002927:Cimetidine / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004357:Drug Synergism; D005913:Glipizide / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011899:Ranitidine / Q000494:pharmacology*
D001786:Blood Glucose; D002927:Cimetidine; D011899:Ranitidine; D005913:Glipizide