Serum albumin and prealbumin as predictors of clinical outcomes of hospitalized elderly nursing home residents.
OBJECTIVE
To investigate the prevalence of hypoalbuminemia and hypoprealbuminemia in hospitalized, elderly, skilled nursing facility residents and to correlate these findings with clinical outcomes.


METHODS
Prospective cohort study.


METHODS
A 300-bed community hospital.


METHODS
Eighty-one hospitalized, skilled nursing facility patients, average age 83.1 years.


METHODS
None.


METHODS
Serum albumin and prealbumin (transthyretin) were measured at admission, mid-week, 1 week, and 1 month. Patients were followed for 90 days for the outcomes of length of hospitalization and mortality.


RESULTS
The prevalence of hypoalbuminemia was 99% and of hypoprealbuminemia, 79%. Both means dropped significantly from admission to midweek nadirs of 25 g/L for albumin and 14 mg/L for prealbumin. Severe hypoalbuminemia at mid-week predicted mortality (RR = 4.1 95%, CI 2.0-8.5) and extended length of hospitalization (RR = 5.2 95%, CI 2.8-9.8). Severe hypoprealbuminemia predicted extended hospitalization (RR = 3.2, CI 1.5-6.7) but not mortality.


CONCLUSIONS
Hypoalbuminemia and hypoprealbuminemia are very common in this clinical setting and vary in parallel fashion over time. Severe hypoalbuminemia was a stronger predictor than hypoprealbuminemia of 90-day mortality and extended length of stay. Serum albumin on admission was not as strong a predictor of outcomes as serum albumin at mid-week.
Ferguson
R P
RP
Mount Sinai Hospital, Hartford, CT.
O'Connor
P
P
Crabtree
B
B
Batchelor
A
A
Mitchell
J
J
Coppola
D
D
D000368:Aged; D000369:Aged, 80 and over; D003237:Connecticut / Q000453:epidemiology; D005260:Female; D006745:Hospital Bed Capacity, 300 to 499; D017052:Hospital Mortality; D006764:Hospitals, Community / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male; D017063:Outcome Assessment, Health Care / Q000592:standards*; D010343:Patient Admission; D011228:Prealbumin / Q000032:analysis*; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D012709:Serum Albumin / Q000592:standards*; D012866:Skilled Nursing Facilities
D011228:Prealbumin; D012709:Serum Albumin