title: Use of metyrapone to treat pituitary-dependent hyperadrenocorticism in a cat with large cutaneous wounds.
abstract: Metyrapone, a drug that inhibits cortisol production, was used to lower plasma cortisol concentration and alleviate skin lesions caused by pituitary-dependent hyper-adrenocorticism in a cat. Plasma cortisol concentration was documented by ACTH stimulation test results. During metyrapone treatment, alopecia, thin skin, and large cutaneous wounds resolved. Metyrapone was administered orally at a dosage of 65 mg/kg of body weight, every 12 hours. Metyrapone may be used in conjunction with surgery in the management of pituitary-dependent hyperadrenocorticism in cats.
authors: Department of Small Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5523.
authors: C A
authors: CA
authors: Daley
authors: C A
authors: CA
authors: Zerbe
authors: R O
authors: RO
authors: Schick
authors: R D
authors: RD
authors: Powers
mesh_terms: D000315:Adrenalectomy / Q000662:veterinary; D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D002415:Cats; D003131:Combined Modality Therapy; D003480:Cushing Syndrome; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008797:Metyrapone / Q000627:therapeutic use*; D012867:Skin / Q000293:injuries*; D014947:Wounds and Injuries / Q000209:etiology / Q000662:veterinary*
chemical_list: D006854:Hydrocortisone; D008797:Metyrapone