title: Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
abstract: Receptors for the major excitatory neurotransmitter glutamate may play key roles in neurodegeneration. The mouse Glur-5 gene maps to chromosome 16 between App and Sod-1. The homologous human GLUR5 gene maps to the corresponding region of human chromosome 21, which contains the locus for familial amyotrophic lateral sclerosis. This location, and other features, render GLUR5 a possible candidate gene for familial amyotrophic lateral sclerosis. In addition, dosage imbalance of GLUR5 may have a role in the trisomy 21 (Down syndrome). Further characterization of the murine glutamate receptor family includes mapping of Glur-1 to the same region as neurological mutants spasmodic, shaker-2, tipsy, and vibrator on chromosome 11; Glur-2 near spastic on chromosome 3; Glur-6 near waltzer and Jackson circler on chromosome 10; and Glur-7 near clasper on chromosome 4.
authors: Molecular Neurobiology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224.
authors: P
authors: P
authors: Gregor
authors: R H
authors: RH
authors: Reeves
authors: E W
authors: EW
authors: Jabs
authors: X
authors: X
authors: Yang
authors: W
authors: W
authors: Dackowski
authors: J M
authors: JM
authors: Rochelle
authors: R H
authors: RH
authors: Brown
authors: J L
authors: JL
authors: Haines
authors: B F
authors: BF
authors: O'Hara
authors: G R
authors: GR
authors: Uhl
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D003433:Crosses, Genetic; D015342:DNA Probes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D008969:Molecular Sequence Data; D009115:Muridae; D009422:Nervous System Diseases / Q000235:genetics*; D009838:Oligodeoxyribonucleotides; D017470:Receptors, Glutamate / Q000235:genetics*; D011995:Recombination, Genetic; D015183:Restriction Mapping
chemical_list: D015342:DNA Probes; D009838:Oligodeoxyribonucleotides; D017470:Receptors, Glutamate