The novel 5-HT4 receptor antagonist DAU 6285 antagonizes 5-hydroxytryptamine-induced tachycardia in pigs.
The 5-HT4 receptor antagonist action of DAU 6285 was investigated in vivo in anesthetized pigs. DAU 6285 (0.3-3 mg/kg i.v.) dose dependently antagonized 5-hydroxytryptamine (5-HT)-induced tachycardiac responses. In contrast, the 5-HT3 receptor antagonist, ondansetron (0.3-3 mg/kg i.v.) did not influence the tachycardia induced by 5-HT. These results indicate that DAU 6285 is a potent antagonist of 5-HT4 receptor-mediated responses in vivo.
Van Meel
J C
JC
Department of Pharma Research, Dr. Karl Thomae GmbH, Biberach/Riss, Germany.
Diederen
W
W
Haigh
R
R
Wienen
W
W
Pairet
M
M
Turconi
M
M
Doods
H N
HN
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004305:Dose-Response Relationship, Drug; D008297:Male; D012701:Serotonin / Q000633:toxicity*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013552:Swine; D013610:Tachycardia / Q000139:chemically induced* / Q000517:prevention & control*
D001562:Benzimidazoles; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D012702:Serotonin Antagonists; C074390:DAU 6285; D012701:Serotonin