title: Material damping for monitoring of density and strength of bones.
abstract: The aim of this work was a preliminary assessment of the feasibility of using in vivo measurements of mechanical properties of bones to detect mineral loss and further to relate them to the tendency of the bone to fracture in the case of loss of minerals, such as in osteoporosis. Previous studies of bone strength in vitro have demonstrated that the decrease in bone strength in both the spine and the femur has strong correlation with the mineral content (BMC) measured with bone densitometry. It was demonstrated that loss of mineral in the bone is accompanied by substantial change of the main mechanical properties, decrease of the Young's modulus, and increase of the damping factor. The change in those properties is one order of magnitude greater than the change in bone density. Moreover, increase of bone density, by way of training, resulted in decrease of the damping factor that also was substantially greater than the change in density. The tests showed clearly that the change in mechanical properties was much greater than the change in bone mass density. This offers an attractive new alternative to the detection of bone mass loss as it appears that the change of the bone mass is well correlated to the change in these mechanical properties. In particular, the change in the damping factor of the material was found to be much more substantial than the bone density change. Therefore, the damping mechanism offers the vehicle for a direct assessment of the bone tendency to fracture due to the loss of mass, as tendency to fracture and mass loss are known to be related.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Mechanical Engineering, School of Engineering, Washington University, St. Louis, Missouri 63130.
authors: A D
authors: AD
authors: Dimarogonas
authors: S H
authors: SH
authors: Abbasi-Jahromi
authors: L V
authors: LV
authors: Avioli
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D002645:Chickens; D005269:Femur; D006851:Hydrochloric Acid; D066298:In Vitro Techniques; D008433:Mathematics; D010024:Osteoporosis / Q000503:physiopathology; D010805:Physical Conditioning, Animal; D051381:Rats; D013977:Tibia
chemical_list: D006851:Hydrochloric Acid