Pharmacokinetics of cefotaxime in neonatal pony foals.
Serum concentrations of cefotaxime and desacetylcefotaxime were measured in 1-week-old pony foals after IV administration of a single dose of cefotaxime. The cefotaxime disposition data conformed to a two-compartment model with elimination half-life of 0.60 hour. The combined cefotaxime and desacetylcefotaxime data was best described by a four-compartment model. The apparent half-life describing the disappearance of desacetylcefotaxime was 1.69 hours. Dosage of 40 mg/kg of body weight given IV every 4 to 6 hours for neonatal foals with gram-negative septicemia and every 2 hours for foals with meningitis is recommended for further study.
Gardner
S Y
SY
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
Sweeney
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RW
Divers
T J
TJ
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D006736:Horses; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D013997:Time Factors
C029281:desacetylcefotaxime; D002439:Cefotaxime