A human vascular disorder, supravalvular aortic stenosis, maps to chromosome 7.
The pathogenesis of vascular disease is unclear, but genetic factors play an important role. In this study we performed linkage analyses in two families with supravalvular aortic stenosis, an inherited vascular disorder that causes narrowing of major arteries and may lead to cardiac overload and failure. DNA markers on the long arm of chromosome 7 (D7S371, D7S395, D7S448, and ELN) were linked to supravalvular aortic stenosis in both families with a combined logarithm of likelihood for linkage (lod score) of 5.9 at the ELN locus. These findings indicate that a gene for supravalvular aortic stenosis is located in the same chromosomal subunit as elastin, which becomes a candidate for the disease gene.
Ewart
A K
AK
Department of Human Genetics, University of Utah, Salt Lake City 84112.
Morris
C A
CA
Ensing
G J
GJ
Loker
J
J
Moore
C
C
Leppert
M
M
Keating
M
M
D001024:Aortic Valve Stenosis / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D004247:DNA / Q000235:genetics; D004549:Elastin / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D011995:Recombination, Genetic
D005819:Genetic Markers; D009838:Oligodeoxyribonucleotides; D004247:DNA; D004549:Elastin