Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in neonatal rats.
Neuroprotective effects of basic fibroblast growth factor (bFGF) (200 mu/kg i.p.) were examined at different time points following intrastriatal injection of N-methyl-D-aspartate (NMDA) in seven-day-old rats. When administered 0.5 h before intrastriatal NMDA injection, 200 micrograms/kg of bFGF significantly reduced NMDA-induced lesion by 47% as compared with vehicle treatment. Posttreatment with the same dose of bFGF at 0, 0.5 or 1 h after NMDA injection also significantly reduced those lesions by 45, 35 or 26%, respectively, while no neuroprotective effects was observed when administered at 2 or 4 h after NMDA injection.
Nozaki
K
K
Stroke Research, Massachusetts General Hospital, Boston 02114.
Finklestein
S P
SP
Beal
M F
MF
D000818:Animals; D000831:Animals, Newborn; D003342:Corpus Striatum; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D007274:Injections, Intraperitoneal; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D009422:Nervous System Diseases / Q000139:chemically induced / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D016222:Fibroblast Growth Factor 2; D016202:N-Methylaspartate