[Blood gas changes during hypotensive anesthesia induced by prostaglandin E1].
The influence of prostaglandin E1 (PGE1) on PaO2 at doses that produced slight hypotension was evaluated in 176 patients scheduled for surgery. When systolic blood pressure was stabilized after induction of anesthesia, PGE1 infusion was started until 20% reduction of systolic blood pressure was achieved. Arterial blood gases were analyzed before infusion of PGE1 and 30 min after the completion of this hypotensive level respectively. The reductions in both PaO2 [from 177 +/- 64 mmHg to 164 +/- 65 mmHg (mean +/- SD) (P < 0.01)] and PaO2/FIO2 [from 486.5 +/- 144.4 to 437.6 +/- 121.6 (P < 0.01)] were observed with PGE1 infusion of 0.079 +/- 0.068 micrograms.kg-1.min-1. The results of this study show that PaO2 decreases during induced hypotension with PGE1 infusion, but this decrease is not clinically significant.
Yasuda
S
S
Department of Anesthesiology, Keio University, School of Medicine, Tokyo.
Takahashi
J
J
Takeda
J
J
Sekiguchi
H
H
Fukushima
K
K
D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000494:pharmacology*; D006801:Humans; D007023:Hypotension, Controlled; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure
D000527:Alprostadil; D010100:Oxygen