title: Abnormal cervical cytology following large loop excision of the transformation zone: a case controlled study.
abstract: OBJECTIVE
  To determine factors that may predict cytological outcome at 6 months following large loop excision of transformation zone (LLETZ) for cervical intra epithelial neoplasia (CIN) and to investigate the outcome in women with continuing cytological abnormality.
  
  
  METHODS
  Case controlled retrospective study.
  
  
  METHODS
  Dudley Road Hospital, Birmingham and Midland Hospital for Women.
  
  
  METHODS
  Fifty-eight women with abnormal follow up cytology and a control group of 116 women.
  
  
  METHODS
  The relation between pretreatment and treatment factors and cytological outcome, and the relation between cytology and histology in women who had biopsies for persistent abnormal cytology.
  
  
  RESULTS
  Univariate and stepwise logistic regression analysis showed that the number of sectors of atypical transformation zone (lesion size) and the excision margin status of the large loop excision specimen are of prognostic importance for the prediction of cytological abnormality at the 6 month follow up visit. Sixteen women have undergone further cervical biopsy. Of the five cases of persistent CIN, four had cytological changes showing moderate or severe dyskaryosis. Of the 11 women with koilocytosis or normal histology, 10 had mild dyskaryosis or borderline changes on their follow up cytology.
  
  
  CONCLUSIONS
  Lesion size and excision margin status are important correlates of follow up cytology when treating patients for CIN with LLETZ. All women with abnormal cervical cytology at follow up should undergo colposcopic assessment. Excision biopsy is indicated if follow up cytology shows moderate or severe dyskaryosis, especially if still present 12 months after treatment.
authors: Academic Department of Obstetrics and Gynaecology, Dudley Road Hospital, Birmingham, UK.
authors: M I
authors: MI
authors: Shafi
authors: J A
authors: JA
authors: Dunn
authors: E J
authors: EJ
authors: Buxton
authors: C B
authors: CB
authors: Finn
authors: J A
authors: JA
authors: Jordan
authors: D M
authors: DM
authors: Luesley
mesh_terms: D000367:Age Factors; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D004564:Electrocoagulation; D005260:Female; D006801:Humans; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D014626:Vaginal Smears