[The effect of cytostatic and immunomodulator therapy on the morphology of the tumor and lymphoid organs and on the count of large granular lymphocytes in the blood of mice with Lewis carcinoma].
Effects of separate and combined therapy with nitrosomethylurea (NMU), methotrexate thymalin, and reaferon on tumor, thymus and spleen morphology as well as the content of large granular lymphocytes in blood were studied in mice with Lewis lung carcinoma. The study revealed different effects of methotrexate and NMU on tumor and lymphoid organs. The direct NMU damage to tumor was accompanied by a suppression of host immune system which was only slightly reversed with immunomodulators. The cytotoxic antitumor effect of methotrexate was probably related also with the stimulation of host immune system, its cells in turn affecting the size of proliferating tumor fraction.
Potapov
Iu I
IuI
Khaleev
D V
DV
Krutova
T V
TV
Pashkova
V S
VS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D007958:Leukocyte Count / Q000187:drug effects; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects*; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation
D000276:Adjuvants, Immunologic
Vliianie terapii tsitostatikami i immunomoduliatorami na morfologiiu opukholi, limfoidnykh organov i soderzhanie bol'shikh granuloarnykh limfotsitov v krovi mysheĭ s kartsinomoĭ L'iuis.