title: [Development of endocrine orbitopathy in pregnancy].
abstract: A report is given on an endocrine orbitopathy in a 24-year-old female in which the disease deteriorated from the 3rd month of pregnancy, with a severe restriction of motility, exophthalmia (Hertel exophthalmometer both eyes 28 mm), severe visual field defects and a decrease of visual acuity to 20/200 both eyes. Therefore--despite of certain restraints of the pharmacologic therapy during pregnancy--glucocorticoid-treatment was started. After delivery, the condition deteriorated, despite of a higher steroid dose. Therefore, a retrobulbar irradiation was begun on the 12th day post partum (telecobalt 10 Gy). From that time on all signs improved over the next months (visual acuity 20/25; exophthalmometer both eyes 20 mm, normal visual field). In the literature, endocrine orbitopathy (Graves' ophthalmopathy) during pregnancy has been mentioned sporadically, but to our knowledge such a severe case, as reported here, has not been described before.
authors: Universitäts-Augenklinik Bonn.
authors: Z
authors: Z
authors: Nüssgens
authors: P
authors: P
authors: Roggenkämper
authors: H U
authors: HU
authors: Schweikert
mesh_terms: D000328:Adult; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005448:Fluocortolone / Q000008:administration & dosage; D005500:Follow-Up Studies; D006111:Graves Disease / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000628:therapy*; D011644:Puerperal Disorders / Q000175:diagnosis / Q000628:therapy; D011867:Radioisotope Teletherapy
chemical_list: D003037:Cobalt Radioisotopes; D005448:Fluocortolone
vernacular_title: Entwicklung einer endokrinen Orbitopathie während einer Schwangerschaft.