Study of the neurobehavioural toxicity of styrene at low levels of exposure.
Thirty workers in a dockyard exposed to concentrations of styrene lower than the TLV-TWA of 50 ppm and 30 control workers not subject to exposure but employed by the same company were subjected to three psychometric tests on one Monday morning and evening. The results were usually better in the evening than in the morning in both groups, which proves the lack of acute intoxication at the end of the day at this level of exposure. On the other hand, all of the tests conducted on the exposed subjects are significantly less good than those on the controls. The results suggest the existence of minor but significant organic mental disorders in the subjects exposed to a mean dose of 30 ppm in this study. These results are inconsistent with those of several recent studies. The advisability of lowering the TLV of 50 ppm in discussed.
Jégaden
D
D
Service de Médecine du Travail, DCN Lorient, Délégation Générale pour l'Armement, France.
Amann
D
D
Simon
J F
JF
Habault
M
M
Legoux
B
B
Galopin
P
P
D000328:Adult; D001921:Brain / Q000187:drug effects; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D010468:Perceptual Disorders / Q000139:chemically induced*; D011594:Psychometrics; D020058:Styrene; D013343:Styrenes / Q000009:adverse effects* / Q000032:analysis; D014785:Vision, Ocular / Q000187:drug effects
D013343:Styrenes; D020058:Styrene