[Basic reproductive toxicological studies of the effect of furazolidone on the hypothalamo-hypophyseo-gonadal axis of male rats].
The reproductive-toxic effects of furazolidone on testis, epididymis and selected nuclei of the hypothalamus of male wistar rats were investigated. After a dosage of 50 mg/kg b.w. daily over five days no changes of testis and epididymis were detected in relation to controls by means of light microscope. Using morphometric methods a significant increase of the nucleus volume of the measured nuclei of the hypothalamus (Ncl. ventromedialis, Ncl. praeopticus medialis, Ncl. infundibularis) could be shown. After the high dosage of 200 mg/kg b.w. daily for five days testis and epididymis showed marked signs of atrophy and the volume of the investigated nuclei of the hypothalamus was significantly increased. These results suggest that--contrary to the wide spread opinion the testis would react most sensitive to chemical agents--more attention should be directed to the hypothalamus in reproductive-toxicological studies.
Zimmermann
H
H
Veterinärmedizinische Fakultät, Universität Leipzig.
Gutte
G
G
Kern
M
M
Golbs
S
S
Ludewig
T
T
D000818:Animals; D004822:Epididymis / Q000187:drug effects*; D005664:Furazolidone / Q000633:toxicity*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects*
D005664:Furazolidone
Reproduktionstoxikologische Grundlagenuntersuchungen zur Wirkung von Furazolidon auf die Achse Hypothalamus--Hypophyse-Gonaden der männlichen Ratte.