Development of vaginal adenosis following combined 5-fluorouracil and carbon dioxide laser treatments for diffuse vaginal condylomatosis.
BACKGROUND
The management of vaginal human papillomavirus (HPV) lesions may be difficult. We report an unusual long-term consequence of treatment.


METHODS
A 40-year-old woman presented with vaginal adenosis following treatment of multiple vaginal condylomata by endovaginal applications of 5% 5-fluorouracil cream and vaporization of the remaining subclinical condylomata by CO2 laser.


CONCLUSIONS
The approach to the management of vaginal condylomatosis should take into consideration the possible later occurrence of adenosis.
Bornstein
J
J
Department of Obstetrics and Gynecology, Carmel Medical Center and Hatechnion-Rapapport School of Medicine, Haifa, Israel.
Sova
Y
Y
Atad
J
J
Lurie
M
M
Abramovici
H
H
D000328:Adult; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects*; D013997:Time Factors; D014621:Vagina / Q000473:pathology; D014623:Vaginal Diseases / Q000209:etiology* / Q000473:pathology; D014625:Vaginal Neoplasms / Q000628:therapy*
D005472:Fluorouracil