Possible selective effects of interferon alpha-2b on a malignant clone in a case of polycythemia vera.
A patient with polycythemia vera associated with chromosomal translocation (6;8) (q27;p11) and IgA monoclonal gammopathy was treated with interferon alpha-2b. Interferon alpha-2b induced good hematological control and reduced only IgA levels, but not IgG and IgM levels. In addition, cytogenetic improvement was obtained, the abnormal cells with chromosomal translocation declining from 100% to 50%. Interferon alpha may have selective effects on a malignant clone in polycythemia vera.
Hino
M
M
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Futami
E
E
Okuno
S
S
Miki
T
T
Nishizawa
Y
Y
Morii
H
H
D002871:Chromosome Banding; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D002999:Clone Cells / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D011994:Recombinant Proteins; D014178:Translocation, Genetic
D007070:Immunoglobulin A; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins