[Evaluation of the possible ototoxicity of josamycin by high frequency audiometry].
Josamycin is an antibiotic macrolide similar to erythromycin, with some differences in its biologic behaviour. There have been no reports of ototoxic effects caused by this drug, but its similitudes with erythromycin have prompted us to undertake a study about its possible cochleo-toxicity. Most trials of this kind have been carried out using conventional audiometry (up to 8,000 Hz), thus not being able to detect threshold shifts above this frequency. Ototoxic lesions usually begin in the upper frequency limit. Twenty-eight patients without previous auditory impairment were studied with conventional (up to 8,000 Hz) and high-frequency audiometry (up to 20,000 Hz) before and after oral treatment with josamycin during eight days. No significant differences were found in auditory thresholds registered before and after treatment in any of the patients. These results suggest that josamycin is devoid of any cochleo-toxic effect in all the frequencies that a normal subject can hear.
Doménech
J
J
Catedra de O.R.L., Facultad de Medicina (Hospital Clinic), Universidad de Barcelona.
Cuchí
M A
MA
Fusté
J
J
Traserra Coderch
J
J
D000328:Adult; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D003051:Cochlea / Q000187:drug effects; D004917:Erythromycin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006309:Hearing / Q000187:drug effects*; D006801:Humans; D015570:Josamycin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy*
D004917:Erythromycin; D015570:Josamycin
Evaluacíon de la posible ototoxicidad de la josamicina mediante audiometría de alta frecuencia.