title: Treatment of severe diabetes mellitus for more than one year using a vascularized hybrid artificial pancreas.
abstract: We report the successful application of a hybrid artificial pancreas device for the treatment of severe diabetes mellitus induced by total pancreatectomy in two dogs. Control of the blood sugar was achieved for more than 1 year in these two animals without any immunosuppressive therapy. Although exogenous insulin was required therapy. Although exogenous insulin was required during the latter part of the study period, removal of the devices resulted in a rapid increase in the fasting blood sugar levels and the exogenous insulin requirements (P < 0.001 versus weeks 1-52 in both dogs). Metabolic studies, postexplant in vitro studies, and histologic analyses confirmed islet cell survival and insulin production by the devices. This hybrid artificial pancreas has a clear clinical potential for islet cell transplantation without immunosuppression.
authors: Division of Organ Transplantation, New England Deaconess Hospital, Boston, Massachusetts.
authors: T
authors: T
authors: Maki
authors: J P
authors: JP
authors: Lodge
authors: M
authors: M
authors: Carretta
authors: H
authors: H
authors: Ohzato
authors: K M
authors: KM
authors: Borland
authors: S J
authors: SJ
authors: Sullivan
authors: J
authors: J
authors: Staruk
authors: T E
authors: TE
authors: Muller
authors: B A
authors: BA
authors: Solomon
authors: W L
authors: WL
authors: Chick
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D004285:Dogs; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D007332:Insulin Infusion Systems; D010180:Pancreatectomy; D013997:Time Factors
chemical_list: D001786:Blood Glucose