title: The effect of continuous interscalene brachial plexus block with 0.125% bupivacaine plus fentanyl on diaphragmatic motility and ventilatory function.
abstract: OBJECTIVE
  Continuous interscalene brachial plexus block with 0.25% bupivacaine decreases diaphragmatic motility and ventilatory function. The author studied the effects of 0.125% bupivacaine with and without fentanyl.
  
  
  METHODS
  Forty patients who were to undergo shoulder surgery were given an interscalene brachial plexus block using 20-28 ml 0.75% bupivacaine plus epinephrine. In random order, 10 patients then had a 24-hour continuous block with 0.125% bupivacaine (BUPI) (5-9 ml/h). Nine patients had an additional s.c. infusion of fentanyl (F-SC) (15-27 micrograms/h) and 10 the same dose of fentanyl with the bupivacaine infusion (F-PLX). Ten patients had a single block (PLX) for minor surgery. Spirometry, double-exposure chest radiography, pulse oximetric hemoglobin saturation and maximal airway pressures were measured.
  
  
  RESULTS
  Postoperatively, BUPI patients were given, on average, 1.2, F-SC patients 0.7, and F-PLX patients 0.4 doses of oxycodone in 24 hours (not significant). Average ipsilateral diaphragmatic motility was reduced to 8% in F-PLX group (p < 0.01) and to 19-30% in the other groups (p < 0.05). At 24 hours, average motility in BUPI, F-SC, F-PLX and PLX groups was 54, 48, 31 and 91%, respectively. In all groups FVC, FEV1 and PEF were reduced by 20-40% at 3 hours (p < 0.001). At 8 and 24 hours, FVC and FEV1 were in F-SC and F-PLX groups significantly lower (p < 0.05) than in PLX group.
  
  
  CONCLUSIONS
  Use of 0.125% bupivacaine for continuous interscalene block did not prevent a deterioration of diaphragmatic motility and ventilatory function. Co-infusion of fentanyl did not significantly potentiate the block.
authors: Department of Anesthesia, Helsinki University Central Hospital, Finland.
authors: P
authors: P
authors: Pere
mesh_terms: D000328:Adult; D001917:Brachial Plexus; D002045:Bupivacaine; D003964:Diaphragm / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005283:Fentanyl; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D012782:Shoulder / Q000601:surgery*
chemical_list: D005283:Fentanyl; D002045:Bupivacaine