Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system.
This is the third part of a review on the transport of drugs across the blood-brain barrier. In the first two parts, the anatomical and physiological aspects and the various techniques that can be used to study blood-brain transport have been discussed and reviewed. This third part focuses specifically on the mechanisms that are involved in drug transport across the blood-brain barrier. In addition, the opportunities to improve drug transport into the brain will be reviewed. Emphasis is on the transport of peptides.
Van Bree
J B
JB
Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Leiden University, The Netherlands.
De Boer
A G
AG
Danhof
M
M
Breimer
D D
DD
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*
D004364:Pharmaceutical Preparations