Calprotectin in patients with systemic lupus erythematosus: relation to clinical and laboratory parameters of disease activity.
Calprotectin (L1) is a granulocyte and monocyte cytosolic protein released during activation of these cells. The plasma level of L1 has been shown to be a good marker of disease activity in rheumatoid arthritis. In this cross-sectional study of 100 patients with systemic lupus erythematosus (SLE), the serum level of L1 was found to be higher in patients than in matched controls (3661 micrograms/l versus 1051 micrograms/l; P < 0.001). The serum level of L1 was the only laboratory parameter with significant association to the disease activity index SLEDAI (r = 0.28; P < 0.01). Furthermore, the serum level of L1 was significantly higher in SLE patients with anti-DNA antibodies compared to patients without anti-DNA antibodies (4501 micrograms/l versus 3279 micrograms/l; P = 0.01). SLE patients with arthritis had higher serum levels of L1 than patients without arthritis (7652 micrograms/l versus 2811 micrograms/l; P < 0.01), indicating that the serum level of L1 also reflects arthritis activity in SLE.
Haga
H J
HJ
Department of Rheumatology, Haukeland Hospital, Bergen, Norway.
Brun
J G
JG
Berntzen
H B
HB
Cervera
R
R
Khamashta
M
M
Hughes
G R
GR
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000097:blood*; D005260:Female; D006801:Humans; D039841:Leukocyte L1 Antigen Complex; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D015415:Biomarkers; D015816:Cell Adhesion Molecules, Neuronal; D039841:Leukocyte L1 Antigen Complex; D002097:C-Reactive Protein