Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites.
A total of 34 different apo(a) isoforms was identified in a population sample of 806 American Whites and 701 American Blacks by a high resolution SDS-agarose gel electrophoretic method followed by immunoblotting. Among the 1507 individuals tested, 79% revealed double-banded phenotypes and 21% single-banded phenotypes. The frequencies of the apo(a) isoforms differed between American Blacks and Whites (p < 0.001).
Marcovina
S M
SM
Department of Medicine, Northwest Lipid Research Laboratories, University of Washington, Seattle, WA.
Zhang
Z H
ZH
Gaur
V P
VP
Albers
J J
JJ
D000483:Alleles; D001053:Apolipoproteins / Q000235:genetics*; D053241:Apoprotein(a); D044383:Black People / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D006801:Humans; D017270:Lipoprotein(a); D014481:United States; D044465:White People / Q000235:genetics*; D001741:Black or African American
D001053:Apolipoproteins; D017270:Lipoprotein(a); D053241:Apoprotein(a)