The usefulness of cell surface markers in predicting the prognosis of non-Hodgkin's lymphomas.
The Working Formulation for classification of non-Hodgkin's lymphomas provides useful prognostic information. Since this scheme was published in 1982, many studies have investigated the prognostic significance of various cell surface markers in lymphoma cases. This article reviews the value of distinguishing T cells from B cells, CD5+ B cells, immunoglobulin light chain types, proliferation antigens such as Ki 67, other markers of B-cell differentiation, and chromosomal anomalies. Each of these contributes some further prognostic significance to that already determined by the Working Formulation.
Baird
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Laboratory Services, Department of Veterans Affairs Medical Center, San Diego, CA 92161.
D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor; D002462:Cell Membrane / Q000378:metabolism; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D005544:Forecasting; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D007130:Immunoglobulin Idiotypes; D011947:Receptors, Antigen, B-Cell