title: Systemic sclerosis following anti-androgenic treatment for prostatic adenocarcinoma.
abstract: We describe a male patient who developed systemic sclerosis following orchiectomy, radiotherapy and anti-androgenic treatment for prostatic adenocarcinoma. This case appears interesting as it further supports the possibility of a relationship between neoplasia and systemic sclerosis. The concurrence of scleroderma and iatrogenic hypoandrogenism suggests that hormonal influences may also play a role in the pathogenesis of this connective tissue disorder.
authors: Institute of Rheumatology, University of Siena, Italy.
authors: N
authors: N
authors: Giordano
authors: L
authors: L
authors: Magaro
authors: L
authors: L
authors: Fattorini
authors: P
authors: P
authors: Marcucci
authors: E
authors: E
authors: Battisti
authors: A
authors: A
authors: Fioravanti
authors: R
authors: R
authors: Marcolongo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000726:Androgen Antagonists / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D017373:Cyproterone Acetate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy
chemical_list: D000726:Androgen Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D017373:Cyproterone Acetate; D008775:Methylprednisolone