Molecular cloning and complete nucleotide sequence of genomic RNA of the AIK-C strain of attenuated measles virus.
Twelve cDNA clones covering the entire genome of the AIK-C strain of a seed for live measles vaccine were obtained, and the nucleotide sequences were determined. The full viral genomic RNA consists of 15,894 nucleotides. Comparisons of the nucleotide sequence and the deduced amino acid sequence between the AIK-C and other Edmonston strains revealed the following changes: 56 nucleotide differences and one C residue insertion, 31 amino acid changes, and 19 silent mutations.
Mori
T
T
Department of Virology, Kitasato Institute, Tokyo, Japan.
Sasaki
K
K
Hashimoto
H
H
Makino
S
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000235:genetics; D006801:Humans; D007223:Infant; D008458:Measles Vaccine / Q000302:isolation & purification; D008459:Measles virus / Q000235:genetics*; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics*; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014613:Vaccines, Attenuated / Q000302:isolation & purification; D014764:Viral Proteins / Q000235:genetics
D004279:DNA, Viral; D008458:Measles Vaccine; D012367:RNA, Viral; D014613:Vaccines, Attenuated; D014764:Viral Proteins