[Surfactant therapy in severe neonatal respiratory failure--multicenter study--II. Surfactant therapy in 10 newborn infants with meconium aspiration syndrome].
As a part of a west german multicenter study (424 patients, 16 hospitals) 10 term neonates ventilated because of severe meconium aspiration syndrome were treated with 1-4 doses of 50 mg/kg/BW of a bovine surfactant (Alveofact). Before treatment respiratory distress was severe (median FiO2: 1.0, median MAD 9.9 mmHg, median OI: 20). Acute improvement ("responders") was shown in 4 patients. All patients survived. Time of mechanical ventilation was 6-26 d. High frequency ventilation was applied in two nonresponders, ECMO in one.
Blanke
J G
JG
Universitäts-Kinderklinik Münster.
Jorch
G
G
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000008:administration & dosage*; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000097:blood / Q000628:therapy*; D010100:Oxygen / Q000097:blood; D010743:Phospholipids; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012121:Respiration, Artificial
D008055:Lipids; D010743:Phospholipids; D011663:Pulmonary Surfactants; C078272:SF-RI 1, bovine surfactant preparation; D010100:Oxygen
Surfactanttherapie bei schwerer neonataler Ateminsuffizienz--Multizentrische Studie--II. Surfactanttherapie bei 10 Neugeborenen mit Mekoniumaspirationssyndrom.