title: Fatal disseminated adenovirus type 2 infection following bone marrow transplantation for Hurler's syndrome: a primary infection.
abstract: A 5-month-old girl given an allogeneic bone marrow transplant for Hurler's syndrome succumbed to fatal pneumonia 5 weeks after the transplant. Adenovirus type 2 was isolated from her urine before she died. Immunoperoxidase and electron microscopical studies of liver and lungs post mortem confirmed a disseminated adenovirus infection. The serological findings and the patient's young age suggested that the infection was a primary one. The importance of considering exogenous sources of adenovirus infection in bone marrow transplant recipients is discussed.
authors: Department of Virology, Booth Hall Children's Hospital, Manchester, U.K.
authors: D J
authors: DJ
authors: Morris
authors: G
authors: G
authors: Corbitt
authors: A S
authors: AS
authors: Bailey
authors: M
authors: M
authors: Newbould
authors: E
authors: E
authors: Smith
authors: S
authors: S
authors: Picton
authors: R F
authors: RF
authors: Stevens
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000209:etiology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008059:Mucopolysaccharidosis I / Q000628:therapy*