In vivo evidence of all-trans retinoic acid inducing maturation in acute promyelocytic leukaemia.
All-trans retinoic acid therapy induces maturation in acute promyelocytic leukaemia. We document in vivo evidence of differentiation by all-trans retinoic acid in a case of acute promyelocytic leukaemia which was characterized by cytoplasmic vacuolations.
Hamidah
H N
HN
Haematology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
Cheong
S K
SK
Ainoon
O
O
D001853:Bone Marrow / Q000648:ultrastructure; D002454:Cell Differentiation; D005260:Female; D006098:Granulocytes / Q000648:ultrastructure; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D014212:Tretinoin / Q000627:therapeutic use*; D014617:Vacuoles / Q000473:pathology
D014212:Tretinoin