title: Coeliac plexus block with bupivacaine reduces intestinal dysfunction in neurosurgical ICU patients.
abstract: Coeliac plexus block, an established method of treatment for pain associated with pancreatitis and cancer, was used in neurosurgical patients with gastrointestinal dysfunction. The study was performed in 16 patients whose gastric reflux volume exceeded 600 ml per day for 3 consecutive days. Patients were allocated to a block group (n = 8) or a control group (n = 8). Coeliac plexus block was accomplished with a modified Moore technique using 50 ml bupivacaine 0.25%. In the block group, gastric reflux volumes for 3 days preceding coeliac plexus block and 3 consecutive days following coeliac plexus block were analysed. In the control group, gastric reflux volumes were observed over a period of 6 days. Mean (SEM) gastric reflux volume decreased significantly following coeliac plexus block from 770 (50) ml to 60 (30) ml (p < 0.01). In the control group, gastric reflux remained unchanged over the corresponding periods (730 (60) ml c.f. 670 (50) ml). The response of gastric reflux volume to coeliac plexus block suggests that the mechanism is related to inhibition of sympathetic activity in patients whose sympathetic drive is increased due to the underlying neurological disease, and possibly due to sedation withdrawal symptoms.
authors: Department of Anaesthesia and General Intensive Care, University of Vienna, Austria.
authors: C
authors: C
authors: Weinstabl
authors: P
authors: P
authors: Porges
authors: B
authors: B
authors: Plainer
authors: A
authors: A
authors: Werba
authors: C K
authors: CK
authors: Spiss
authors: H
authors: H
authors: Seitz
mesh_terms: D000328:Adult; D000368:Aged; D001340:Autonomic Nerve Block; D001921:Brain / Q000601:surgery; D002045:Bupivacaine; D002447:Celiac Plexus; D006259:Craniocerebral Trauma / Q000601:surgery; D005260:Female; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009493:Neurosurgery; D011183:Postoperative Complications / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D002045:Bupivacaine