title: Preservation of renal function in juxtarenal and suprarenal abdominal aortic aneurysm repair.
abstract: OBJECTIVE
  Deterioration in renal function is a common cause of morbidity in patients treated surgically for juxtarenal and suprarenal abdominal aortic aneurysms. We reviewed our experience over the last 8 years with 65 consecutive patients undergoing juxtarenal (n = 31) or suprarenal (n = 34) abdominal aortic aneurysm repair.
  
  
  METHODS
  The aneurysms were repaired with a transabdominal (n = 8), thoracoabdominal (n = 4), retroperitoneal (n = 22), or thoracoretroperitoneal (n = 31) approach. Proximal aortic clamps were placed at the suprarenal, supra-superior mesenteric artery, or supraceliac level. Renal hypothermia with cold heparinized saline solution renal artery perfusion was used to protect renal function in 38 patients with either preoperative renal insufficiency or with anticipated prolonged renal ischemia (> 30 minutes). Concomitant renal artery reconstruction was required in 30 patients.
  
  
  RESULTS
  Significant operative morbidity developed in 23 (35.3%) patients. There was one (1.53%) perioperative death (0 to 90 days). Temporary dialysis was necessary in two patients. Preoperative renal insufficiency was a significant risk factor on multivariate analysis for a decline in renal function during the first postoperative week. However, serum creatinine concentration had returned to baseline or improved in all patients but two (3.1%) at the time of discharge. In spite of significantly longer renal ischemia, discharge creatinine levels were, on univariate analysis, statistically less than baseline creatinine levels in patients with suprarenal aneurysms, patients requiring renal reconstruction, and patients treated with renal hypothermia. The location of the proximal aortic clamp was not a factor in postoperative morbidity. There was no significant difference between juxtarenal and suprarenal aneurysms with respect to operating room time, transfusion requirements, days intubated, resumption of oral diet, or the length of hospitalization.
  
  
  CONCLUSIONS
  Careful consideration of the route of exposure, location of the proximal aortic clamp, and the preservation of renal function with renal hypothermia and with the repair of significant renal artery lesions will result in minimal morbidity and mortality in patients requiring surgery for juxtarenal or suprarenal abdominal aortic aneurysms.
authors: Department of Surgery, Washington University School of Medicine, St. Louis.
authors: B T
authors: BT
authors: Allen
authors: C B
authors: CB
authors: Anderson
authors: B G
authors: BG
authors: Rubin
authors: M W
authors: MW
authors: Flye
authors: D S
authors: DS
authors: Baumann
authors: G A
authors: GA
authors: Sicard
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000601:surgery; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D003250:Constriction; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D015994:Incidence; D007430:Intraoperative Care / Q000379:methods; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009017:Morbidity; D011183:Postoperative Complications / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D012077:Renal Artery / Q000601:surgery; D051437:Renal Insufficiency / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control