title: Parathyroid carcinoma presenting with a brown tumour of the mandible in a young man.
abstract: A 27-year-old man presented to his dentist with a swelling in his lower jaw. Histology revealed this to be a brown tumour associated with primary hyperparathyroidism and severe but asymptomatic hypercalcaemia. A large parathyroid adenoma was removed and the serum calcium fell to normal. Hypercalcaemia recurred and re-exploration of the neck revealed parathyroid metastases in cervical lymph nodes. A modified radical neck dissection was performed and he has remained normocalcaemic on Vitamin D analogues for 2 years. Bone disease of the mandible is a very rare presentation of primary hyperparathyroidism. The diagnosis of parathyroid malignancy is often difficult histologically, and the optimum treatment is uncertain.
authors: Department of Medicine, University of Liverpool.
authors: E A
authors: EA
authors: Masson
authors: I A
authors: IA
authors: MacFarlane
authors: C W
authors: CW
authors: Bodmer
authors: E D
authors: ED
authors: Vaughan
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D000328:Adult; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006961:Hyperparathyroidism / Q000209:etiology / Q000473:pathology / Q000628:therapy; D008297:Male; D008339:Mandibular Neoplasms / Q000556:secondary* / Q000601:surgery; D037981:Neck Dissection; D010282:Parathyroid Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008926:Plicamycin / Q000627:therapeutic use
chemical_list: D008926:Plicamycin