Efficacy of the somatostatin analog octreotide in the treatment of two patients with refractory diabetic diarrhea.
Two patients with severe refractory diabetes-related diarrhea are described. One patient had steatorrhea. Both responded to octreotide during a mean follow-up period of 7 months. The pathophysiology of diabetic diarrhea and the potential mechanism of action of octreotide are discussed. The only adverse side effect reported was hypoglycemia in one of the patients, which required a reduction of the insulin dose. Octreotide is a safe and effective agent for the treatment of refractory diabetic diarrhea.
Walker
J J
JJ
Department of Medicine, University Hospital, State University of New York Health Science Center, Syracuse.
Kaplan
D S
DS
D000328:Adult; D002446:Celiac Disease / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003967:Diarrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D013997:Time Factors
D015282:Octreotide