title: [The drug treatment of postoperative pain].
abstract: The study, conducted on 40 patients with pain resulting from "minor" general surgery, for the purpose of evaluating the efficacy and tolerability of ST-679 (administered in a single oral dose of 1200 mg in 20 patients) and to compare them with those of paracetamol (administered in a single oral dose of 1000 mg in 20 patients), demonstrated that the new drug was active on all recorded parameters and superior to the reference drug. The evaluation of the evolution of pain, performed using the Scott-Huskisson visual analog scale, evidenced that the maximum analgesic efficacy of ST-679 is reached after 1 hour and 15 minutes from assumption and remains unaltered until the final observation (6 hours). The paracetamol registers maximum analgesic efficacy after 30 minutes, but does not remain constant for the entire observation period. All the other parameters evaluated (variation in pain intensity, peak of analgesic activity and total remission of pain) are significantly favorable to ST-679. The tolerability of ST-679 was very good and better than the reference drug.
authors: Divisione di Chirurgia Generale, USSL 72, Ospedale G. Fornaroli, Magenta (MI).
authors: G
authors: G
authors: Nanni
authors: G
authors: G
authors: Sarro
authors: G
authors: G
authors: Antoci
authors: P
authors: P
authors: Bianchi
authors: F
authors: F
authors: Gossetti
authors: M
authors: M
authors: Catarci
authors: M
authors: M
authors: La Pinta
authors: P
authors: P
authors: Negro
authors: G
authors: G
authors: Nolfe
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D013511:Minor Surgical Procedures; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011758:Pyrroles / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; C065762:ST 679; D000082:Acetaminophen; D005998:Glycine
vernacular_title: Trattamento farmacologico del dolore postoperatorio.