Sequence of a newly identified Mycobacterium tuberculosis gene encoding a protein with sequence homology to virulence-regulating proteins.
Analysis of the nucleotide sequence of a gene cloned from a Mycobacterium tuberculosis H37Rv genomic library predicted a 339-amino-acid protein with an M(r) of 37,656. The protein exhibited significant homology with the Cfad, FapR and Rns proteins from different enterotoxigenic strains of Escherichia coli, VirF protein of Shigella and VirFy protein of Yersinia, all of which regulate virulence-associated genes.
Gupta
S
S
Department of Biochemistry, University of Delhi South Campus, India.
Tyagi
A K
AK
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D008074:Lipoproteins; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors
C075966:Ag38 antigen, Mycobacterium tuberculosis; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C069375:CfaD protein, E coli; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C067955:FAPR protein, E coli; D008074:Lipoproteins; D015534:Trans-Activators; D014157:Transcription Factors; D037521:Virulence Factors