Effects of isosorbide in patients with Menière's disease.
The effects of isosorbide on vertigo, disability, hearing loss and tinnitus in 32 patients with Menière's disease were evaluated after a 24-month observation period. Vestibular symptoms in 80% of patients were assessed as improved according to the 1985 AAO-HNS post-treatment reporting criteria. In contrast, the effect of this osmotic diuretic on cochlear symptoms was limited.
Kanda
K
K
Department of Otolaryngology, Toyama Medical and Pharmaceutical University, Japan.
Watanabe
Y
Y
Shojaku
H
H
Ito
M
M
Mizukoshi
K
K
D000284:Administration, Oral; D001301:Audiometry, Pure-Tone; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007547:Isosorbide / Q000627:therapeutic use*; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D004856:Postural Balance / Q000187:drug effects; D014012:Tinnitus / Q000188:drug therapy
D007547:Isosorbide