Effects of cetirizine versus terfenadine in seasonal allergic rhinitis.
The purpose of this study was to compare the efficacy and safety of cetirizine, 10 mg, once daily in the morning to terfenadine, 60 mg, BID in the treatment of seasonal allergic rhinitis. The multicenter, single-blind, parallel study involved 160 patients, who were all included in the safety and efficacy analysis. The results of the study showed that both cetirizine, 10 mg, QD and terfenadine, 60 mg, BID used for 1 week are safe and effective in the management of allergic rhinitis. By repeated measures analysis, cetirizine improved symptoms more than terfenadine for the treatment period of days four to seven. Standard Cochran-Mantel-Haenszel statistics test showed the relative degree of patient satisfaction to be higher in the cetirizine group.
Lockey
R F
RF
Division of Allergy and Immunology, University of South Florida, College of Medicine.
Findley
S
S
Mitchell
D Q
DQ
Woehler
T
T
Lieberman
P
P
Nicodemus
C F
CF
D000328:Adult; D017332:Cetirizine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D016037:Single-Blind Method; D016593:Terfenadine / Q000009:adverse effects / Q000627:therapeutic use*
D016593:Terfenadine; D017332:Cetirizine