title: Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients.
abstract: OBJECTIVE
  To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk.
  
  
  METHODS
  The study had a double-blind, cross-over design. Insulin sensitivity was measured with the euglycemic hyperinsulinemic glucose clamp technique at two different insulin infusion rates: 0.05 (clamp 1) and 0.10 U.kg-1.h-1 (clamp 2).
  
  
  RESULTS
  Subanalysis of the glucose infusion rate under steady-state conditions in the last 30 min of clamp 2 yielded a glucose infusion rate of 5.36 and 3.87 mmol.kg-1.min-1 after benfluorex and placebo, respectively (P = 0.018).
  
  
  CONCLUSIONS
  Benfluorex increases insulin sensitivity in obese type II diabetic patients.
authors: Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.
authors: R
authors: R
authors: Bianchi
authors: V
authors: V
authors: Bongers
authors: B
authors: B
authors: Bravenboer
authors: D W
authors: DW
authors: Erkelens
mesh_terms: D016632:Apolipoprotein A-I / Q000032:analysis; D001055:Apolipoproteins B / Q000097:blood; D001067:Appetite Depressants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015309:Glucose Clamp Technique; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity; D010919:Placebos; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D001067:Appetite Depressants; D001786:Blood Glucose; D002096:C-Peptide; D002784:Cholesterol; D005277:Fenfluramine; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; D010919:Placebos; D014280:Triglycerides; C001584:benfluorex