title: Partial thyroarytenoid myectomy: an animal study investigating a proposed new treatment for adductor spasmodic dysphonia.
abstract: A new surgical procedure with potential application for the treatment of adductor spasmodic dysphonia was performed on ten rabbits to assess surgical effects on laryngeal function. Using an external approach, partial unilateral thyroarytenoid (TA) muscle excision was performed through a thyroplasty cartilage window. The contralateral side was left undisturbed as a control. The animals were studied acutely and at 3 months using videolaryngoscopy. Electrophysiologic measurements were recorded at 3 months. The procedure was well tolerated by all animals, with no postoperative infection or aspiration. At 3 months, spontaneous and evoked (recurrent laryngeal nerve stimulation) TA muscle electromyographic potentials were measurable bilaterally. TA compound muscle action potential amplitudes were reduced on the side of myectomy. The threshold of recurrent laryngeal nerve stimulation needed to produce observable vocal fold adduction was increased on the side operated on. Perioperative and long-term (3 months) videolaryngoscopy demonstrated preservation of laryngeal competence with good true vocal cord adduction. Histologic analysis with whole organ sections showed replacement of excised muscle with loose fibroareolar tissue. No evidence of muscle regeneration was observed. The vocal ligament and vocal fold mucosa were intact and undistorted in all specimens. This procedure is technically simple and appears to effectively result in a functional yet weakened TA muscle. Because myectomy includes motor unit end-plate excision, problems associated with reinnervation may be circumvented. TA myectomy may be applicable in patients with focal laryngeal dystonia to decrease muscle spasm.
authors: Department of Otolaryngology and Communication Sciences, State University of New York Health Science Center, Syracuse 13210.
authors: S H
authors: SH
authors: Genack
authors: P
authors: P
authors: Woo
authors: R H
authors: RH
authors: Colton
authors: D
authors: D
authors: Goyette
mesh_terms: D000818:Animals; D001193:Arytenoid Cartilage / Q000473:pathology / Q000601:surgery; D004558:Electric Stimulation; D004576:Electromyography; D004848:Epithelium / Q000473:pathology; D007820:Laryngeal Mucosa / Q000601:surgery; D007821:Laryngeal Muscles / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007828:Laryngoscopy; D011817:Rabbits; D012009:Recurrent Laryngeal Nerve / Q000503:physiopathology; D012684:Sensory Thresholds / Q000502:physiology; D013035:Spasm / Q000503:physiopathology / Q000601:surgery; D013957:Thyroid Cartilage / Q000473:pathology / Q000601:surgery; D014741:Video Recording; D014827:Vocal Cords / Q000473:pathology / Q000503:physiopathology; D014832:Voice Disorders / Q000503:physiopathology / Q000601:surgery*; D014945:Wound Healing