Tissue-specific modulation of rat glucocorticoid receptor binding activity by melatonin.
The effect of melatonin and 2-Iodo-melatonin on nuclear and cytosolic glucocorticoid receptors in the brain, pituitary, thymus and liver has been examined. The results indicate that both melatonin and 2-Iodo-melatonin administration is associated with marked changes in the density and the affinity of cytosolic and nuclear forms of glucocorticoid receptors. These observations are discussed in the context of a possible involvement of pineal melatonin in the mechanisms regulating the behaviour and metabolism of steroid receptors.
Persengiev
S P
SP
Department of Immunoneuroendocrinology, Bulgarian Academy of Sciences, Sofia.
Kondova
I I
II
D000818:Animals; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000187:drug effects* / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D008550:Melatonin