title: Structural modifications associated with the change in Ca2+ sensitivity on activation of m-calpain.
abstract: Autolysis of the Ca(2+)-dependent cysteine protease m-calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca2+ sensitivity. The appearance of increased Ca2+ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.
authors: Laboratory of Molecular Biophysics, University of Oxford, UK.
authors: N
authors: N
authors: Brown
authors: C
authors: C
authors: Crawford
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002154:Calpain / Q000737:chemistry / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D007668:Kidney / Q000201:enzymology; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013552:Swine
chemical_list: D002154:Calpain; D002118:Calcium