title: Parenteral isradipine reduces blood pressure in hypertensive crisis.
abstract: The efficacy and tolerability of an infusion of isradipine, a calcium antagonist of the dihydropyridine type, were tested in patients in hypertensive crisis. Ten patients with symptomatic and significant elevations in blood pressure were infused for 12 h with isradipine at 1.2, 2.4, 4.8, and 7.2 micrograms/kg/h (3 h of each infusion level). No untoward effects or adverse reactions were noted. No alterations were observed on electrocardiographic tracings, and blood pressure was significantly reduced only at doses of 7.2 micrograms/kg/h. Thus, isradipine as an infusion is useful and safe for hypertensive crisis, starting at a rate of 7.2 micrograms/kg/h. Higher doses may yet prove to be safe, well tolerated, and even more efficacious.
authors: Hypertension-Nephrology Division, Paulista School of Medicine, São Paulo, Brazil.
authors: M A
authors: MA
authors: Saragoça
authors: R A
authors: RA
authors: Mulinari
authors: A F
authors: AF
authors: Oliveira
authors: J
authors: J
authors: Portela
authors: F L
authors: FL
authors: Plavnik
authors: D
authors: D
authors: Melegari
authors: O L
authors: OL
authors: Ramos
mesh_terms: D000208:Acute Disease; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007262:Infusions, Intravenous; D017275:Isradipine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D017275:Isradipine