Solid-state nuclear magnetic resonance spectroscopy: theory and pharmaceutical applications.
The theory of solid-state nuclear magnetic resonance (NMR) spectroscopy is reviewed, with specific discussions of magnetic interactions in the solid state. Each magnetic interaction (Zeeman, dipole-dipole, chemical-shift, spin-spin, and quadrupolar) is addressed and manifestations of these interactions in the solid state NMR spectrum are explained. The techniques of high-power decoupling, magic-angle spinning, and cross-polarization, used to acquire highly resolved solid-state NMR spectra, are also illustrated. Application of solid-state NMR to pharmaceutical problem solving and methods development is then briefly reviewed.
Bugay
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Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey 08903-0191.
D002626:Chemistry, Pharmaceutical; D009682:Magnetic Resonance Spectroscopy; D004364:Pharmaceutical Preparations / Q000032:analysis*
D004364:Pharmaceutical Preparations