title: Effect of dietary hydrogenated corn oil (trans-octadecenoate rich oil) on plasma and hepatic cholesterol metabolism in the hamster.
abstract: The effect of dietary hydrogenated corn oil (trans-octadecenoate-rich oil) on plasma cholesterol and triglyceride concentrations was compared with dietary palmitic acid in hamsters given a cholesterol-rich diet. The addition of dietary palmitic acid and hydrogenated corn oil accelerated the increase in plasma VLDL- and LDL-cholesterol levels and plasma triglyceride level induced by dietary cholesterol loading. Dietary cholesterol, palmitic acid and hydrogenated corn oil showed no effect on plasma HDL-cholesterol concentration. A decrease in hepatic LDL receptor activity was seen in animals fed a diet supplemented with cholesterol in combination with palmitic acid or hydrogenated corn oil in comparison with animals fed a diet supplemented with cholesterol alone. Hydrogenated corn oil (trans-octadecenoate-rich oil) appears to potentiate the effect of dietary cholesterol in elevating the plasma VLDL- and LDL-cholesterol levels through the suppression of hepatic LDL receptor activity. trans-Octadecenoate in dietary hydrogenated corn oil may be as atherogenic as dietary palmitic acid due to a suppression of hepatic LDL receptors in the presence of dietary cholesterol loading.
authors: First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
authors: K
authors: K
authors: Hayashi
authors: Y
authors: Y
authors: Hirata
authors: H
authors: H
authors: Kurushima
authors: M
authors: M
authors: Saeki
authors: H
authors: H
authors: Amioka
authors: S
authors: S
authors: Nomura
authors: Y
authors: Y
authors: Kuga
authors: Y
authors: Y
authors: Ohkura
authors: H
authors: H
authors: Ohtani
authors: G
authors: G
authors: Kajiyama
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D003314:Corn Oil / Q000008:administration & dosage*; D006224:Cricetinae; D006865:Hydrogenation; D008099:Liver / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism; D013228:Stearates; D014280:Triglycerides / Q000378:metabolism
chemical_list: D002788:Cholesterol Esters; D010169:Palmitic Acids; D010743:Phospholipids; D013228:Stearates; D014280:Triglycerides; D019308:Palmitic Acid; D003314:Corn Oil; D002784:Cholesterol