Penetration of fusidic acid into human brain tissue and cerebrospinal fluid.
Penetration of fusidic acid into brain tissue in six patients and cerebrospinal fluid in seven patients was determined. Tissue samples, taken during surgery revealed drug levels at about 7% of simultaneous serum concentrations. In contrast, cerebrospinal fluid concentrations were below 1% of serum levels. Since serum- and tissue levels of fusidic acid were far above the minimal inhibitory concentration (MICs) of staphylococci and streptococci, and since it has a long serum half-life of about 10 hours, it is a promising candidate for prophylaxis in neurosurgery.
Mindermann
T
T
Neurochirurgische Universitätsklinik, Kantonsspital Basel, Switzerland.
Zimmerli
W
W
Rajacic
Z
Z
Gratzl
O
O
D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000097:blood / Q000601:surgery*; D001932:Brain Neoplasms / Q000097:blood / Q000601:surgery; D002540:Cerebral Cortex / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000097:blood / Q000517:prevention & control*
D005672:Fusidic Acid