title: Self-assembling properties of synthetic peptidic lipids.
abstract: Novel peptidic lipids were synthesized by the coupling of a linear oligopeptide as the hydrophilic moiety with a glutamic acid dialkylamide as the hydrophobic moiety. Their self-assembling properties were investigated. The critical aggregate concentrations (CAC) for the peptidic lipids with a double dodecyl group were in the range of 1.0 x 10(-5)-3.8 x 10(-5) M. The phase transition parameters and the aggregation morphologies in aqueous dispersion were largely dependent on the number and nature of the constitutive amino acid residues. Dark-field optical microscopy demonstrated that the present peptidic lipids can form four types of stable morphologies in water, i.e., tubular structures, twisted ribbons, vesicles, and amorphous crystals.
authors: Surface Engineering Laboratory, Research Institute for Polymers and Textiles, Ibaraki, Japan.
authors: T
authors: T
authors: Shimizu
authors: M
authors: M
authors: Hato
mesh_terms: D000595:Amino Acid Sequence; D002152:Calorimetry, Differential Scanning; D008055:Lipids / Q000737:chemistry*; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*
chemical_list: D008055:Lipids; D010455:Peptides