Modulation of biological responses of normal human mononuclear cells by antiestrogens.
The effect of three non-steroidal antiestrogens, Tamoxifen, Toremifene and ICI 164, 384, on various aspects of the immune response was studied in cultures of normal peripheral mononuclear blood cells. The drugs differ somewhat in their effect on the functions tested (pokeweed mitogen-induced immunoglobulin synthesis and cell proliferation, mixed lymphocyte reaction, Interleukin 2 (IL 2) synthesis, IL 2 receptor expression and Tumor Necrosis Factor (TNF alpha) synthesis). However, all three are immunosuppressive. On the other hand, ICI 164, 384 and Tamoxifen were stimulatory for TNF alpha production by adherent cells which may prove as an additional feature in antiestrogen treatment.
Teodorczyk-Injeyan
J
J
Department of Surgery, University of Toronto, Sunnybrook Health Science Centre, Ontario, Canada.
Cembrzynska-Nowak
M
M
Lalani
S
S
Kellen
J A
JA
D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology; D007155:Immunologic Factors / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D053284:Polyunsaturated Alkamides; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013629:Tamoxifen / Q000494:pharmacology; D017312:Toremifene / Q000494:pharmacology
D004965:Estrogen Antagonists; D007136:Immunoglobulins; D007155:Immunologic Factors; D053284:Polyunsaturated Alkamides; D013629:Tamoxifen; D004958:Estradiol; D017312:Toremifene; C051781:ICI 164384