Antitumor activity and interleukin-1 induction by tannins.
The relationships between structures, antitumor activities and interleukin-1 (IL-1) induction by fifteen tannins were studies. When tannins (10 mg/kg) were intraperitoneally injected into mice once, 4 days before intraperitoneal inoculation of S-180 cells, tellimagrandin II, rugosin A, hirtellin B, oenothein B and oenothein A, which have only tellimagrandins I or II units in their molecules, had significant antitumor activity. Although casuarictin and its related tannins were ineffective, agrimonin, which is a dimer, had a strong effect, as previously reported. On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction. Other tannins having no antitumor activity induced less IL-beta. This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1 beta.
Miyamoto
K
K
Research Laboratory for Development of Medicine, Hokuriku University, School of Pharmacy, Kanazawa, Japan.
Murayama
T
T
Nomura
M
M
Hatano
T
T
Yoshida
T
T
Furukawa
T
T
Koshiura
R
R
Okuda
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology; D013329:Structure-Activity Relationship; D013634:Tannins / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007375:Interleukin-1; D013634:Tannins