[Heterogeneity of delta virus RNA sequences in Japan].
Hepatitis delta virus RNA sequences were determined in isolates from two Japanese patients, M and S, by polymerase chain reaction and direct nucleotide sequencing and compared with three isolates from Italy, USA and Taiwan. The sequence obtained for hepatitis delta virus RNA from patient M was 92-96% identical to the sequences obtained for three other strains of hepatitis delta virus, whereas the sequence of hepatitis delta virus RNA obtained from patient S was approximately 80% identical to the other sequenced strains. This suggests that the delta agent in Japan has a heterogeneous origin and the delta virus RNA sequence from Japanese patient S is the most divergent delta virus isolate yet analyzed.
Imazeki
F
F
First Department of Medicine, Chiba University School of Medicine.
Omata
M
M
D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D016679:Genome, Viral; D003699:Hepatitis D / Q000235:genetics / Q000382:microbiology; D003698:Hepatitis Delta Virus / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D012367:RNA, Viral