Immunoglobulin G immunosuppression of multiple sclerosis. Suppression of all three major lymphocyte subsets.
Six patients with relapsing chronic progressive multiple sclerosis were treated on 2 consecutive days with large amounts of IgG to induce immunosuppression. Peripheral blood lymphocyte subsets were monitored for 5 weeks after IgG treatment to determine immunosuppression. Decreased numbers of B, T, and natural killer lymphocytes were detected after treatment. Lymphocyte numbers were at a nadir 1 week after treatment, but an immunosuppressive effect continued to be present after 5 weeks. Although clinical efficacy was not evident in this brief open trial, the decrease of peripheral lymphocyte numbers and the apparent safety of the procedure warrant further study.
Tenser
R B
RB
Division of Neurology, Penn State University College of Medicine, Hershey.
Hay
K A
KA
Aberg
J A
JA
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D016756:Immunoglobulins, Intravenous; D007165:Immunosuppression Therapy; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy*; D010865:Pilot Projects; D013601:T-Lymphocytes; D050378:T-Lymphocytes, Regulatory
D015703:Antigens, CD; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous