Utilization of pediatric donors salvaged by cardiopulmonary resuscitation.
The efficacy of using infant donors with an extended cardiopulmonary resuscitation (CPR) history was investigated. Eight heart transplantations with donors who had no or minimal (less than 10 minutes) history of CPR (group A) and seven heart transplantations with donors with extended CPR history (35 to 125 minutes; mean, 59 minutes; group B) were compared for peak myosin levels after transplantation, and systolic and diastolic cardiac function in the first week after transplantation. All donor hearts had normal hemodynamics in the early postoperative period. No significant differences were found between the groups with regard to age of donors, age of recipients, donor heart ischemic time, and cardiac function in the first week after transplantation. In group B, peak myosin levels were 1.4, 4.6, 7.0, 11.3, 14.8, 20.2, and 21.3 ng/ml. These values were significantly (p < 0.05) higher than those in group A but represented only minimal myocardial damage when compared with the values in previous myocardial infarction studies. Although donors with a history of protracted CPR had higher efflux of myosin light chains perioperatively, hemodynamic recovery suggests that use of pediatric donor heart grafts after prolonged CPR is safe and efficacious.
Kawauchi
M
M
Department of Surgery, School of Medicine, Loma Linda University Medical Center, Calif. 92354.
Gundry
S R
SR
de Begoña
J A
JA
Razzouk
A J
AJ
Bailey
L L
LL
D000367:Age Factors; D016887:Cardiopulmonary Resuscitation; D002675:Child, Preschool; D005260:Female; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009218:Myosins / Q000097:blood; D014019:Tissue Donors
D009218:Myosins