title: Rapid and sensitive pre-column extraction high-performance liquid chromatographic assay for propofol in biological fluids.
abstract: A completely automated high-performance liquid chromatographic system is described for the determination of the phenolic anaesthetic propofol. The method is based on pre-column extraction in a closed system allowing direct injection of biological samples without any sample pretreatment. The assay is sensitive (limit of quantification is 5 ng/ml serum), reliable (the variability within a series is 2%) and rapid (results are available after 6 min).
authors: Klinik für Anaesthesiologie und Intensivmedizin, Universität des Saarlandes, Homburg/Saar, Germany.
authors: P
authors: P
authors: Altmayer
authors: U
authors: U
authors: Büch
authors: H P
authors: HP
authors: Büch
authors: R
authors: R
authors: Larsen
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015742:Propofol / Q000032:analysis* / Q000097:blood / Q000652:urine; D011485:Protein Binding; D013056:Spectrophotometry, Ultraviolet
chemical_list: D015742:Propofol