[Microbial saprotrophic pharmacotherapy: the possible indications, the conditions for its realization and the overall strategy].
Potential indications for bacterial strains-producers of biologically active substances to be utilized for microbial saprotrophic pharmacotherapy are presented. These indications include some infectious diseases and tumors, a number of noninfectious diseases, transplantation and contraception. The cardinal problem of microbial pharmacotherapy, the capacity of strains-producers of getting acclimatized to the patient organism, is discussed. For its solution, a "microbiological passportization of a patient" ("saprotrophic mapping"), that is drawing up a map of patient microbiological status, is proposed. This "saprotrophic secretory passportization (mapping)" of strains-producers is first submitted for consideration. A strategy of future microbial pharmacotherapy is stated. The necessity of careful approbation of this kind of therapy is emphasized.
Piruzian
L A
LA
Mikhaĭlovskiĭ
E M
EM
D000375:Aging; D000818:Animals; D018407:Bacterial Physiological Phenomena; D001685:Biological Factors / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity; D003141:Communicable Diseases / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008722:Methods
D001685:Biological Factors
Mikrobnaia saprotrofnaia farmakoterapiia: vozmozhnye pokazaniia, usloviia realizatsii i obshchaia strategiia.