title: Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2-receptor antagonists.
abstract: In a randomised placebo controlled study, two groups of six maturity onset diabetic patients stabilised on glipizide were given cimetidine (400 mg) or ranitidine (150 mg) 3 h before a standardised meal. In comparison with placebo, both cimetidine and ranitidine significantly reduced the post-prandial rise in blood glucose by a mean of 40% and 25% respectively producing glucose levels of less than 3 mmol l-1 (lowest 1.5 mmol l-1) in four patients. Both drugs also significantly increased plasma glipizide AUC by approximately 20%. Caution should be exercised when initiating treatment with H2-receptor antagonists in diabetics receiving sulphonylurea hypoglycaemic agents.
authors: Department of Therapeutics, Trinity College, Dublin.
authors: J
authors: J
authors: Feely
authors: W C
authors: WC
authors: Collins
authors: M
authors: M
authors: Cullen
authors: A H
authors: AH
authors: el Debani
authors: R S
authors: RS
authors: MacWalter
authors: N R
authors: NR
authors: Peden
authors: I H
authors: IH
authors: Stevenson
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D002927:Cimetidine / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004357:Drug Synergism; D005913:Glipizide / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011899:Ranitidine / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D002927:Cimetidine; D011899:Ranitidine; D005913:Glipizide