Telazol and xylazine anesthesia in sheep.
The analgesic and anesthetic effects of Telazol (13.2 mg/kg, IV) and xylazine (0.11 mg/kg, IV)-Telazol (13.2 mg/kg, IV) were evaluated in 6 sheep. Anesthesia was characterized by muscle relaxation and profound analgesia with both regimens, muscle relaxation appeared to be better in sheep receiving xylazine-Telazol. The duration of analgesia was significantly longer in sheep receiving xylazine-Telazol (101.7 +/- 26 minutes) than in sheep receiving Telazol alone (41.6 +/- 15 minutes). Changes in heart rate and respiration rate were transient with both regimens. Apnea occurred in 2 sheep immediately after xylazine-Telazol administration, requiring assisted ventilation, but both sheep resumed spontaneous breathing within 2 minutes. Arterial blood pressure decreased significantly at 45 and 60 minutes after xylazine-Telazol injection. Arousal to standing was smooth, but gradual with no significant difference between the two drug regimens. In conclusion, xylazine-Telazol combination produced better muscle relaxation and longer duration of anesthesia than Telazol alone. The adverse effects induced by xylazine-Telazol were similar to that of Telazol.
Lin
H C
HC
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, Alabama 36849-5522.
Tyler
J W
JW
Wallace
S S
SS
Thurmon
J C
JC
Wolfe
D F
DF
D000698:Analgesia / Q000662:veterinary*; D000768:Anesthesia, General / Q000662:veterinary*; D000777:Anesthetics / Q000009:adverse effects; D000818:Animals; D004338:Drug Combinations; D006339:Heart Rate / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012756:Sheep; D013992:Tiletamine / Q000009:adverse effects; D014991:Xylazine / Q000009:adverse effects; D015041:Zolazepam / Q000009:adverse effects
D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D014991:Xylazine; D013992:Tiletamine; D015041:Zolazepam