Hypoglycemic and insulin response to a continuous intravenous infusion of CGP-35126 recombinant human insulin-like growth factor-I (rhIGF-I) in healthy males.
Recombinant human insulin-like growth factor-I (rhIGF-I) produced by expression in a yeast vector was evaluated in seven normal men to determine effects on plasma glucose and insulin levels. Each subject received an initial intravenous infusion of normal saline and on the following day, rhIGF-I at a rate of 21.4 micrograms/kg/hour. Each infusion lasted for 7 hours. The subjects' fasting baseline glucose and insulin levels were not statistically different (P > .05) from their pre-dose levels. Compared with the saline (control) infusion, serum glucose levels were statistically lower (P < .05) 2 hours into the rhIGF-I infusion. These lower glucose levels were maintained until the subjects consumed a standard lunch (4 hours into the infusion). Insulin levels demonstrated a similar response to rhIGF-I, but decreases in insulin levels occurred after the rhIGF-I hypoglycemic effect. This observation suggests that suppression of insulin levels may be due to secondary hypoglycemia rather than to a direct rhIGF-I effect. This study demonstrated the desired rhIGF-I effect of lowering subjects' glucose levels without clinically significant hypoglycemia. This finding suggests that rhIGF-I may have potential clinical utility in hyperglycemic states.
Morgan
J M
JM
Department of Medicine and Pharmacology, Medical College of Pennsylvania, Philadelphia 19129.
Saris
S D
SD
Capuzzi
D M
DM
Good
W R
WR
John
V A
VA
Guler
H P
HP
Seaman
J
J
Piraino
A J
AJ
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005215:Fasting / Q000097:blood; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology; D016037:Single-Blind Method
D001786:Blood Glucose; D007328:Insulin; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I