[The effect of bone-seeking metal salts on the biodistribution of tumor-seeking heavy metal complexes].
This work attempted to overcome the problem of unwanted bone radioactivity after injection of tumour-affine heavy-metal compounds (prototype 169Yb-citrate) by pre-application of stable yttrium- and calcium-compounds into tumour-bearing mice in doses of 1 mg metal/kg body weight. The pre-application of stable yttrium and calcium resulted in a smaller bone radioactivity. The most favourable results were achieved by injecting the metal salts simultaneously at or within 5 h before the 169Yb-citrate. On the other hand a strong radioactivity increase in the RES (liver and spleen) by a factor of 2 to 4 was observed after yttrium-preapplication.
Schomäcker
K
K
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln.
Franke
W G
WG
Weiss
S
S
Lindner
L
L
Jantsch
K
K
Shukla
S K
SK
Limouris
G S
GS
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002125:Calcium Gluconate / Q000627:therapeutic use*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy; D051379:Mice; D009368:Neoplasm Transplantation; D011868:Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011877:Radionuclide Imaging; D015018:Ytterbium / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015019:Yttrium / Q000627:therapeutic use*
D011868:Radioisotopes; D015019:Yttrium; D015018:Ytterbium; D002125:Calcium Gluconate
Der Einfluss von knochenaffinen Metallsalzen auf die Bioverteilung tumoraffiner Schwermetallkomplexe.