Glycogen synthesis in rat liver from a pool of free glucose.
Glycogen synthesis in isolated perfused livers or livers of anesthesized rats (in situ), was studied using radioactively labelled fructose, lactate, and inositol as substrates. The specific radioactivity of glucose and glycogen was measured at various times and compared with that of some intermediates. The results suggest that liver glycogen is formed from the pool of free glucose which in turn is fed by the so-called "direct and indirect pathway" of glycogen synthesis. This points to an important role of glucose-6-phosphatase, an enzyme complex subject to regulation by glucocorticoids, well known promoters of hepatic glycogen synthesis.
Schimassek
H
H
Institut für Biochemie I (Med. Fakultät), Universität Heidelberg, Bundesrepublik Deutschland.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002250:Carbon Radioisotopes; D005632:Fructose / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis*; D008297:Male; D011865:Radioisotope Dilution Technique; D051381:Rats; D017208:Rats, Wistar; D013403:Sugar Phosphates / Q000302:isolation & purification / Q000378:metabolism
D001786:Blood Glucose; D002250:Carbon Radioisotopes; D008112:Liver Glycogen; D013403:Sugar Phosphates; D005632:Fructose; D005934:Glucagon; D005947:Glucose