Role of platelet activating factor in hemodialysis.
A complex array of inflammatory mediators are generated as a consequence of blood contact with hemodialysis (HD) membranes. Beside complement activation, other mediators are involved in cell activation, and are thought possibly to be responsible for early and long-term multiple changes in immunity infection, hypercatabolism, beta 2-microglobulin generation and hemostatic mechanisms. Previous studies from our laboratories have established platelet activating factor (PAF) as one of the mediators generated by complement-dependent or independent mechanisms of cell interaction with hemodialysis membranes. Recent studies on the production of PAF from endotoxin-primed polymorphonuclear neutrophils in a closed miniaturized circuit, and on the effect of PAF in mediating endotoxin- and cytokine-induced leukocyte adherence to HD membranes, highlight so far undescribed new roles of this mediator in biocompatibility.
Tetta
C
C
Bellco Laboratories, Bellco SpA, Mirandola (Mo), Italy.
David
S
S
Biancone
L
L
Canino
F
F
Cambi
V
V
Camussi
G
G
D001790:Blood Physiological Phenomena; D004731:Endotoxins / Q000009:adverse effects; D006801:Humans; D007688:Kidneys, Artificial / Q000009:adverse effects; D007962:Leukocytes / Q000502:physiology; D008567:Membranes, Artificial; D009504:Neutrophils / Q000502:physiology; D010972:Platelet Activating Factor / Q000502:physiology*; D006435:Renal Dialysis / Q000009:adverse effects*
D004731:Endotoxins; D008567:Membranes, Artificial; D010972:Platelet Activating Factor