Hemocompatibility of diamond-like carbon coating.
The new prosthetic heart valve that has been designed by FII Company and Pr. Baudet involves a new "composite" material: titanium alloy T16A14V coated with Diamond-like Carbon. The purpose of this study was to evaluate the in vitro hemocompatibility of this new material in terms of protein adsorption and platelet retention. The static protein adsorption test gave interesting results, particularly for the albumin assay (237%) compared to the results obtained with a silicone elastomer chosen as a reference; the fibrinogen quantity, adsorbed on the surface of the material was slightly higher than that adsorbed on the silicone surface. Platelets adhere quite twice as much as they do on the reference surface. Such investigations showed good hemocompatibility results and should initiate further studies.
Dion
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I
INSERM U.306, Université Bordeaux II 146, France.
Roques
X
X
Baquey
C
C
Baudet
E
E
Basse Cathalinat
B
B
More
N
N
D000327:Adsorption; D000497:Alloys / Q000592:standards*; D001672:Biocompatible Materials / Q000592:standards*; D002244:Carbon / Q000592:standards*; D006350:Heart Valve Prosthesis / Q000592:standards*; D006801:Humans; D008422:Materials Testing; D010973:Platelet Adhesiveness; D011506:Proteins; D011877:Radionuclide Imaging; D012826:Silicone Elastomers / Q000592:standards; D014025:Titanium / Q000592:standards*
D000497:Alloys; D001672:Biocompatible Materials; D011506:Proteins; D012826:Silicone Elastomers; C031462:titanium alloy (TiAl6V4); D002244:Carbon; D014025:Titanium