title: Quantitative microfocal radiography detects changes in erosion area in patients with early rheumatoid arthritis treated with myocrisine.
abstract: Patients with early rheumatoid arthritis (RA) were randomly divided into those receiving gold early (n = 13) or 6 months later (n = 10). They were followed 6 monthly over 18 months. Mean erosion area in gold and delayed gold, measured from macroradiographs, was comparable at baseline and increased significantly over the first 6 months. In the second 6 months, gold showed no increase and delayed gold an insignificant increase. By the third 6 months both groups showed a decrease. On comparing the second 6 months of gold therapy in gold and delayed gold with a group of patients with RA of similar disease duration (n = 34) not receiving gold, a lower proportion (p < 0.005) had erosion area progression and a higher proportion (p < 0.001) erosion repair.
authors: Division of Anatomy and Cell Biology, United Medical School of Guy's Hospital, London, UK.
authors: J C
authors: JC
authors: Buckland-Wright
authors: G S
authors: GS
authors: Clarke
authors: I C
authors: IC
authors: Chikanza
authors: R
authors: R
authors: Grahame
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000473:pathology; D006046:Gold / Q000008:administration & dosage / Q000627:therapeutic use; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D006225:Hand / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014955:Wrist Joint / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D006052:Gold Sodium Thiomalate; D006046:Gold