[Changes in the intensity of free-radical reactions in the organs of rats under hypokinetic stress and with protection by the delta sleep-inducing peptide and its tyrosine-containing analog].
Dynamics of the hypokinesia-induced changes of free radical and malonic dialdehyde content in brain, the changes of respiratory chain state and superoxide dismutase activity in liver of rats has been studied using ESR technique and biochemical methods. The effect of the preliminary injection of DSIP and its analogue ID-2 on these dynamics has also been studied. Using a model system constants of the interaction between DSIP or ID-2 and O2-. have been determined. The data point to the antioxidant effect of the administration of the peptides before hypokinesia. This suggests that the effect involves in mechanisms of the anti-stress action of these peptides.
Rikhireva
G T
GT
Makletsova
M G
MG
Mendzherkitskiĭ
A M
AM
Vartanian
L S
LS
Gurevich
S M
SM
Lozovskaia
E L
EL
Kopylovskiĭ
S A
SA
Rylova
A V
AV
Prudchenko
I A
IA
Mikhaleva
I I
II
D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004579:Electron Transport / Q000187:drug effects; D005609:Free Radicals; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007103:Immobilization / Q000502:physiology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
D005609:Free Radicals; C039556:delta sleep-inducing peptide, N-Tyr-; D003701:Delta Sleep-Inducing Peptide; D013482:Superoxide Dismutase
Izmeneniia intensivnosti svobodnoradikal'nykh reaktsiĭ v organakh krys pri gipokineticheskom stresse i zashchite del'ta-son-indutsiruiushchim peptidom i ego tirozinsoderzhashchim analogom.