The antimicrobial actions of taurolin and other preparations on the pathogenic spectrum in dentoalveolar infections.
Bacteriological specimens from a total of 64 patients with six common, highly relevant clinical indications were collected for an in vitro investigation. By means of standard microbiological methods, 149 species of organism were differentiated, and their relative sensitivity to Taurolin, a broad spectrum chemotherapeutic and antitoxin, as well as 5 conventional finished pharmaceuticals were tested in agar diffusion tests. Taurolin, which was tested in 3 different galenic formulations, produced practically identical, but considerably wider zones of inhibition than all other compared products. In contrast to other substances which exhibited a failure rate of up to 24.8%, no gaps in the activity spectrum in the form of the lack of inhibition zone formation were observed.
Zimmermann
M
M
Clinic for Maxillofacial Surgery, Munich University, Germany.
Preac-Mursic
V
V
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001422:Bacterial Adhesion / Q000187:drug effects; D001424:Bacterial Infections / Q000382:microbiology*; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D002751:Chlortetracycline / Q000494:pharmacology; D004338:Drug Combinations; D010450:Endopeptidases / Q000494:pharmacology; D006801:Humans; D005779:Immunodiffusion; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology; D010510:Periodontal Diseases / Q000382:microbiology*; D011239:Prednisolone / Q000494:pharmacology; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013829:Thiadiazines / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013829:Thiadiazines; D013654:Taurine; C001122:neomycin, prednisolone, surfen, trypsin-chymotrypsin drug combination; C012566:taurolidine; D014508:Urea; D011239:Prednisolone; D010450:Endopeptidases; D009355:Neomycin; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; D002751:Chlortetracycline