The prolactin response to d- and l-fenfluramine and to d-amphetamine in human subjects.
Twelve normal male volunteers took part in a double-blind placebo-controlled study to measure the effects of d- and l-fenfluramine singly and in combination with d-amphetamine on plasma prolactin levels. Both isomers of fenfluramine were found to differ significantly in their effects from d-amphetamine, and from placebo, causing prolactin levels to rise. d-Fenfluramine produced the greatest change. There were minor differences between the level of activity of the two drugs when given in conjunction with d-amphetamine. d-Amphetamine produced a non-significant reduction in prolactin secretion. The neurochemical basis for the experimental findings reported is considered, with special reference to the use of d-fenfluramine as a specific serotonergic probe.
Feeney
S
S
Academic Unit of Human Psychopharmacology, Medical College of St Bartholomew's Hospital, London, UK.
Goodall
E
E
Silverstone
T
T
D000328:Adult; D000704:Analysis of Variance; D002849:Chromatography, Gas; D003913:Dextroamphetamine / Q000097:blood / Q000494:pharmacology*; D004311:Double-Blind Method; D004347:Drug Interactions; D005277:Fenfluramine / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay; D013237:Stereoisomerism
D005277:Fenfluramine; D011388:Prolactin; D003913:Dextroamphetamine