A direct interview family study of social phobia.
Risks for DSM-III-R anxiety and affective disorders and "subdisorder" (nonimpairing) irrational social fears, among directly interviewed first-degree relatives (n = 83) of probands who met criteria for social phobia but for no other lifetime anxiety disorder diagnosis, were contrasted to risks for disorder among similarly evaluated relatives (n = 231) of never mentally ill controls. Relatives of social phobia probands had a significantly increased risk for social phobia (16% vs 5%, relative risk = 3.12) but not for other anxiety disorders. These results suggest a familial contribution to the development of some cases of social phobia. The specificity of the pattern of intergenerational transmission is consistent with the current nosologic distinction between social phobia and other anxiety disorders.
Fyer
A J
AJ
Department of Therapeutics, New York State Psychiatric Institute, NY 10032.
Mannuzza
S
S
Chapman
T F
TF
Liebowitz
M R
MR
Klein
D F
DF
D000328:Adult; D001008:Anxiety Disorders / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D003937:Diagnosis, Differential; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000145:classification / Q000175:diagnosis* / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D012306:Risk; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000235:genetics