An evaluation of the biological significance of aluminium in plasma and hair of patients on long-term hemodialysis.
In hemodialyzed patients, the risk of toxicity attributed to the body accumulation of aluminium (Al) justifies the need for monitoring Al in various human media. In this study, Al concentrations in the hair and plasma of 78 hemodialyzed patients with chronic renal failure and of 351 healthy volunteers were measured by electrothermal atomic absorption spectrometry with Zeeman effect. Plasma Al concentrations in patients were significantly higher than in the controls and positively correlated with time on dialysis. Hair Al levels were widely distributed with no significant distinction between patients and controls. On the subject of establishing correlation, the authors stress the importance of taking into account the kinetics of the elimination of minerals from hair. Even when this was done, in the patient group there was no statistical link between plasma and hair Al levels. Hair Al analysis is of no value as an indicator of body Al accumulation.
Pineau
A
A
Laboratoire de Toxicologie, Faculté de Pharmacie, Nantes, France.
Guillard
O
O
Huguet
F
F
Speich
M
M
Gelot
S
S
Boiteau
H L
HL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000535:Aluminum / Q000097:blood / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D015203:Reproducibility of Results
D000535:Aluminum