title: High-frequency tone burst-evoked ABR latency-intensity functions.
abstract: High-frequency tone burst stimuli (8, 10, 12, and 14 kHz) have been developed and demonstrated to provide reliable and valid auditory brainstem responses (ABRs) in normal-hearing subjects. In this study, latency-intensity functions (LIFs) were determined using these stimuli in 14 normal-hearing individuals. Significant shifts in response latency occurred as a function of stimulus intensity for all tone burst frequencies. For each 10 dB shift in intensity, latency shifts for waves I and V were statistically significant except for one isolated instance. LIF slopes were comparable between frequencies, ranging from 0.020 to 0.030 msec/dB. These normal LIFs for high-frequency tone burst-evoked ABRs suggest the degree of response latency change that might be expected from, for example, progressive hearing loss due to ototoxic insult, although these phenomena may not be directly related.
authors: Auditory Research Laboratory, Department of Veterans Affairs Medical Center, Portland, Oregon 97207.
authors: S A
authors: SA
authors: Fausti
authors: D J
authors: DJ
authors: Olson
authors: R H
authors: RH
authors: Frey
authors: J A
authors: JA
authors: Henry
authors: H I
authors: HI
authors: Schaffer
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000617:Aminoglycosides / Q000633:toxicity; D001299:Audiometry; D001309:Auditory Threshold; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006309:Hearing / Q000502:physiology*; D006311:Hearing Disorders / Q000139:chemically induced / Q000175:diagnosis*; D006801:Humans; D008297:Male; D012022:Reflex, Acoustic / Q000502:physiology
chemical_list: D000617:Aminoglycosides