title: Genetic mapping of a locus predisposing to human colorectal cancer.
abstract: Genetic linkage analysis was used to determine whether a specific chromosomal locus could be implicated in families with a history of early onset cancer but with no other unique features. Close linkage of disease to anonymous microsatellite markers on chromosome 2 was demonstrated in two large kindreds. The pairwise lod scores for linkage to marker D2S123 in these kindreds were 6.39 and 1.45 at zero recombination, and multipoint linkage with flanking markers resulted in lod scores of 6.47 and 6.01. These results prove the existence of a genetically determined predisposition to colorectal cancer that has important ramifications for understanding and preventing this disease.
authors: Department of Medical Genetics, University of Helsinki, Finland.
authors: P
authors: P
authors: Peltomäki
authors: L A
authors: LA
authors: Aaltonen
authors: P
authors: P
authors: Sistonen
authors: L
authors: L
authors: Pylkkänen
authors: J P
authors: JP
authors: Mecklin
authors: H
authors: H
authors: Järvinen
authors: J S
authors: JS
authors: Green
authors: J R
authors: JR
authors: Jass
authors: J L
authors: JL
authors: Weber
authors: F S
authors: FS
authors: Leach
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003110:Colonic Neoplasms / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D004276:DNA, Satellite / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D012004:Rectal Neoplasms / Q000235:genetics
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers