Biochemical markers of nutrition in osteoporosis.
Thirty-six women with vertebral osteoporosis showed significantly decreased levels of biochemical markers of nutrition, transferrin (P < 0.001), prealbumin (P < 0.001), retinol binding-protein (P < 0.001), and fibronectin (P < 0.001), compared with 40 healthy women of similar age. Multiple regression analysis showed a significant (R2 = 0.509; P = 0.0068) correlation between bone mineral content and biochemical markers of nutrition in the osteoporotic patients but not in the control group. These data suggest that postmenopausal osteoporosis may be associated with a nutritional deficiency.
Rico
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H
Department of Medicine, Principe de Asturias University Hospital, Alcaldá de Henares University, Madrid, Spain.
Relea
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Revilla
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Hernandez
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ER
Arribas
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Villa
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LF
D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008159:Lumbar Vertebrae; D009747:Nutritional Physiological Phenomena; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D011228:Prealbumin / Q000378:metabolism*; D012044:Regression Analysis; D012177:Retinol-Binding Proteins / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
D015415:Biomarkers; D005353:Fibronectins; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D014168:Transferrin