title: Bronchocentric granulomatosis, acute renal failure, and high titer antineutrophil cytoplasmic antibodies: possible variants of Wegener's granulomatosis.
abstract: We describe 2 patients with clinical syndromes suggestive of Wegener's granulomatosis: elevated titers of cytoplasmic antineutrophil cytoplasmic antibodies (cANCA), bronchocentric granulomatosis, and acute renal failure. A renal biopsy in one case showed crescentic glomerulonephritis and in the other case showed interstitial nephritis. These cases may reflect bronchocentric granulomatosis among a spectrum of diseases associated with cANCA. Use of cANCA may identify those patients with bronchocentric granulomatosis who require immunosuppressive therapy.
authors: Department of Medicine, Akron City Hospital, OH 44309.
authors: S W
authors: SW
authors: Fannin
authors: M T
authors: MT
authors: Hagley
authors: J D
authors: JD
authors: Seibert
authors: T J
authors: TJ
authors: Koenig
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers; D001706:Biopsy; D001982:Bronchial Diseases / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000473:pathology; D006099:Granuloma / Q000175:diagnosis / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers