title: Biochemical and immunological properties of two forms of pertactin, the 69,000-molecular-weight outer membrane protein of Bordetella pertussis.
abstract: Two apparent isoforms of the virulence-associated 69,000-molecular-weight protein pertactin were purified from Bordetella pertussis. Mass spectrometry showed a difference of 2,060 Da, which may result from differential C-terminal cleavage of a larger precursor. Both forms were protective in a mouse model, eliciting bactericidal antibodies and reducing respiratory tract colonization.
authors: Lederle-Praxis Biologicals, American Cyanamid Company, Pearl River, New York 10965.
authors: J W
authors: JW
authors: Gotto
authors: T
authors: T
authors: Eckhardt
authors: P A
authors: PA
authors: Reilly
authors: J V
authors: JV
authors: Scott
authors: J L
authors: JL
authors: Cowell
authors: T N
authors: TN
authors: Metcalf
authors: K
authors: K
authors: Mountzouros
authors: J J
authors: JJ
authors: Gibbons
authors: M
authors: M
authors: Siegel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000942:Antigens, Bacterial / Q000737:chemistry; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology; D015153:Blotting, Western; D001886:Bordetella pertussis / Q000737:chemistry* / Q000276:immunology; D007114:Immunization; D013058:Mass Spectrometry; D051379:Mice; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010566:Virulence Factors, Bordetella
chemical_list: D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D010566:Virulence Factors, Bordetella; C068929:pertactin