title: Ethanol-induced changes in plasma proteins, angiotensin II, and salt appetite in rats.
abstract: Sodium depletion in rats elicits a sodium appetite that results from a cerebral action of angiotensin II (ANG II) and aldosterone. Alcohol also activates the renin-angiotensin system, but the mechanism is poorly understood and not related to sodium excretion. In this study, 2.5 g/kg ip ethanol produced a 20% decline in plasma volume and plasma protein concentration in 1-2 hr and elicited salt appetite beginning in 3-4 hr. Blockade of ANG II synthesis in the brain and periphery with the angiotensin-converting enzyme inhibitor captopril eliminated the thirst and salt appetite. Peripheral captopril alone enhanced fluid intake, which indicated that alcohol elevated renin secretion. Ethanol-induced suppression of hepatic plasma protein secretion and the consequent fall in plasma colloid osmotic pressure apparently resulted in hypovolemia and renin secretion, which then produced thirst and salt appetite through an action of ANG II on the brain.
authors: Department of Psychology, University of Washington, Seattle 98195.
authors: D A
authors: DA
authors: Fitts
authors: R G
authors: RG
authors: Hoon
mesh_terms: D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001798:Blood Proteins / Q000378:metabolism*; D001810:Blood Volume / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D012982:Sodium, Dietary / Q000008:administration & dosage*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D001798:Blood Proteins; D012982:Sodium, Dietary; D000804:Angiotensin II; D000431:Ethanol; D002216:Captopril