Therapeutic applications of photopheresis.
Photopheresis is a useful therapy for advanced cutaneous T-cell lymphoma, particularly for Sezary syndrome. Additional conditions in which clinical studies have suggested a therapeutic role for photopheresis include certain autoimmune diseases and reversal of rejection of solid organ allografts. Because photopheresis is extremely well tolerated and evidence is lacking for a direct immunosuppressive effect produced by this therapy, randomized trials should be pursued to determine the full spectrum of clinical benefit of this novel therapeutic modality.
Rook
A H
AH
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.
Cohen
J H
JH
Lessin
S R
SR
Vowels
B R
BR
D001327:Autoimmune Diseases / Q000188:drug therapy*; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy*; D011701:PUVA Therapy / Q000379:methods*; D012878:Skin Neoplasms / Q000188:drug therapy*