Steroids 51. An improved synthesis of ORG 2058 and the synthesis of [3H]ORG 2058.
16 alpha-Ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione (ORG 2058) is a ligand widely used in progesterone receptor assays. An improved synthesis of the compound is reported, starting from norethisterone acetate. The preparation of the tritiated radioligand [3H]ORG 2058 is also described.
Bakos
T
T
Department of Organic Chemistry, Attila József University, Szeged, Hungary.
Lökös
M
M
Vincze
I
I
Volford
J
J
D007553:Isotope Labeling; D015394:Molecular Structure; D009640:Norethindrone / Q000031:analogs & derivatives / Q000737:chemistry; D000077563:Norethindrone Acetate; D011282:Pregnenediones / Q000138:chemical synthesis*; D045167:Progesterone Congeners / Q000138:chemical synthesis*; D014316:Tritium
D011282:Pregnenediones; D045167:Progesterone Congeners; D014316:Tritium; C020175:16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione; D000077563:Norethindrone Acetate; D009640:Norethindrone