title: Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I.
abstract: A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1 (89%) enzymes.
authors: Department of Pharmacology, Fujita Health University School of Medicine, Aichi, Japan.
authors: T
authors: T
authors: Nomura
authors: H
authors: H
authors: Ichinose
authors: C
authors: C
authors: Sumi-Ichinose
authors: H
authors: H
authors: Nomura
authors: Y
authors: Y
authors: Hagino
authors: K
authors: K
authors: Fujita
authors: T
authors: T
authors: Nagatsu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000201:enzymology; D003001:Cloning, Molecular; D004247:DNA; D006136:GTP Cyclohydrolase / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: D004247:DNA; D006136:GTP Cyclohydrolase