title: Telazol and xylazine anesthesia in sheep.
abstract: The analgesic and anesthetic effects of Telazol (13.2 mg/kg, IV) and xylazine (0.11 mg/kg, IV)-Telazol (13.2 mg/kg, IV) were evaluated in 6 sheep. Anesthesia was characterized by muscle relaxation and profound analgesia with both regimens, muscle relaxation appeared to be better in sheep receiving xylazine-Telazol. The duration of analgesia was significantly longer in sheep receiving xylazine-Telazol (101.7 +/- 26 minutes) than in sheep receiving Telazol alone (41.6 +/- 15 minutes). Changes in heart rate and respiration rate were transient with both regimens. Apnea occurred in 2 sheep immediately after xylazine-Telazol administration, requiring assisted ventilation, but both sheep resumed spontaneous breathing within 2 minutes. Arterial blood pressure decreased significantly at 45 and 60 minutes after xylazine-Telazol injection. Arousal to standing was smooth, but gradual with no significant difference between the two drug regimens. In conclusion, xylazine-Telazol combination produced better muscle relaxation and longer duration of anesthesia than Telazol alone. The adverse effects induced by xylazine-Telazol were similar to that of Telazol.
authors: Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, Alabama 36849-5522.
authors: H C
authors: HC
authors: Lin
authors: J W
authors: JW
authors: Tyler
authors: S S
authors: SS
authors: Wallace
authors: J C
authors: JC
authors: Thurmon
authors: D F
authors: DF
authors: Wolfe
mesh_terms: D000698:Analgesia / Q000662:veterinary*; D000768:Anesthesia, General / Q000662:veterinary*; D000777:Anesthetics / Q000009:adverse effects; D000818:Animals; D004338:Drug Combinations; D006339:Heart Rate / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012756:Sheep; D013992:Tiletamine / Q000009:adverse effects; D014991:Xylazine / Q000009:adverse effects; D015041:Zolazepam / Q000009:adverse effects
chemical_list: D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D014991:Xylazine; D013992:Tiletamine; D015041:Zolazepam