Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians.
Debrisoquine and S-mephenytoin hydroxylation polymorphisms were studied in 156 unrelated native Estonians. The hydroxylation phenotypes were assessed by coadministration of mephenytoin with debrisoquine or dextromethorphan. The frequency of the poor metaboliser phenotype of debrisoquine/dextromethorphan was 4.5% (95% confidence interval 1.2-7.8%), and that of mephenytoin was 3.9% (95% confidence interval 0.9-6.9%) among Estonians, which is very similar to what has been reported in other Caucasian populations.
Kiivet
R A
RA
Department of Pharmacology, Tartu University, Estonia.
Svensson
J O
JO
Bertilsson
L
L
Sjöqvist
F
F
D000328:Adult; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003647:Debrisoquin / Q000378:metabolism* / Q000652:urine; D003915:Dextromethorphan / Q000378:metabolism / Q000652:urine; D004957:Estonia; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008617:Mephenytoin / Q000378:metabolism* / Q000652:urine; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*
D003915:Dextromethorphan; D008617:Mephenytoin; D003647:Debrisoquin