title: Positive association between serum zinc and apolipoprotein A-II concentrations in middle-aged males who regularly consume alcohol.
abstract: The relationship of serum zinc with serum concentrations of lipids and apolipoproteins was investigated in 464 male clerical workers aged 35-59 y. Subjects were divided into three groups, by drinking habits. Serum triglycerides, apolipoprotein (apo) A-I, and apo A-II in occasional (2-5 times/wk) and regular (> or = 6 times/wk) drinkers were higher than in non- or seldom (< 1 time/wk) drinkers, whereas serum zinc, total cholesterol (TC), and apo B were not different among groups. Significantly higher high-density-lipoprotein cholesterol (HDL-C) and HDL-C% (HDL-C/TC%) were observed in regular drinkers. Correlation analysis revealed that the serum zinc concentration was positively correlated with apo A-II only in the regular drinkers, and the relationship was significant even after body mass index, smoking habits, and frequency of physical exercise were adjusted for. The results suggest that the individual response of the apo A-II concentration to alcohol is associated with zinc nutritional status in regularly drinking middle-aged men.
authors: Department of Environmental Health Sciences, Tohoku University School of Medicine, Sendai, Japan.
authors: H
authors: H
authors: Koyama
authors: H
authors: H
authors: Hosokai
authors: S
authors: S
authors: Tamura
authors: H
authors: H
authors: Satoh
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D016633:Apolipoprotein A-II / Q000378:metabolism*; D003430:Cross-Sectional Studies; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D015032:Zinc / Q000097:blood*
chemical_list: D016633:Apolipoprotein A-II; D008055:Lipids; D015032:Zinc