title: Sedation with propofol during surgery under local blockade. Assessment of a target-controlled infusion system.
abstract: The ability of a target-controlled propofol infusion system to provide sedation for 40 patients undergoing surgery under regional blockade was assessed. Eighty-eight per cent of the total infusion time was at the desired sedation level with little oversedation. This was achieved with a median blood propofol concentration of 0.93 micrograms.ml-1. The pharmacokinetic algorithm performed as well when used for sedation as for total intravenous anaesthesia. The predicted and measured blood propofol concentrations showed a bias of -12% and a precision of 34%.
authors: Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee.
authors: I G
authors: IG
authors: Skipsey
authors: J R
authors: JR
authors: Colvin
authors: N
authors: N
authors: Mackenzie
authors: G N
authors: GN
authors: Kenny
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D016292:Procedural Sedation / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009407:Nerve Block; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood; D011446:Prospective Studies
chemical_list: D015742:Propofol