title: Stress protein synthesis and accumulation after traumatic injury of crayfish CNS.
abstract: By several days after a crush injury of crayfish CNS, the wound site heals. Changes in protein synthesis and accumulation occur at the lesion site and nearby. During the first few hours, synthesis of 35, 70, 90, and 150 kDa proteins is induced in the injured tissue. By one day, the relative amounts of 70-90 kDa proteins increase dramatically, particularly at the crush site and adjacent to it. The 70 kDa proteins, which are related to mammalian stress proteins (SPs), remain elevated for at least one month in the traumatized region or nearby. The crushed tissue contains an SP70 isoform not present in its uncrushed counterpart. These biochemical changes may reflect the cellular changes that accompany wound healing and/or a cellular stress response to compensate for the lesion. Since similar adaptations occur in the mammalian CNS, they may represent a phylogenetically conserved attempt to retard or repair CNS tissue deterioration.
authors: Zoology Dept. North Carolina State University, Raleigh 27695-7617.
authors: Z Y
authors: ZY
authors: Xue
authors: R M
authors: RM
authors: Grossfeld
mesh_terms: D000818:Animals; D003400:Astacoidea / Q000378:metabolism*; D002490:Central Nervous System / Q000293:injuries / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000378:metabolism; D009409:Nerve Crush; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D006360:Heat-Shock Proteins; D009419:Nerve Tissue Proteins