Comparative effects of tetrandrine and berbamine on guineapig airway microvascular leakage induced by platelet-activating factor and other allergic mediators.
The bisbenzylisoquinoline analogues, tetrandrine and berbamine, were investigated for their effects on guineapig airway microvascular leakage, an animal model of asthma and allergic inflammation. Significant inhibition of microvascular leakage by tetrandrine was observed with all four allergic mediators used in these experiments. By contrast, berbamine was able to suppress microvascular leakage induced by platelet-activating factor and bradykinin, but not by leukotriene D4 or histamine. These results indicate that tetrandrine has broad-spectrum inhibitory activity on allergic mediators, and may have value for the therapy of diseases in which these mediators have a role in pathogenesis.
Wong
C W
CW
Department of Child Health, University of Queensland, Mater Childrens Hospital, South Brisbane, Australia.
Thong
Y H
YH
Seow
W K
WK
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy / Q000209:etiology; D044182:Benzylisoquinolines; D001920:Bradykinin / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006967:Hypersensitivity / Q000188:drug therapy / Q000209:etiology; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology; D012137:Respiratory System / Q000098:blood supply / Q000187:drug effects* / Q000276:immunology; D013189:SRS-A / Q000494:pharmacology
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D044182:Benzylisoquinolines; D010972:Platelet Activating Factor; D013189:SRS-A; C009438:tetrandrine; D006632:Histamine; D001920:Bradykinin; C027870:berbamine