Thrombendarteriitis pulmonalis carcinomatosa Ceelen: an immunohistological investigation.
A 65-year-old woman died in sudden right heart failure caused by thrombendarteriitis pulmonalis carcinomatosa Ceelen 16 months after resection of a rectal carcinoma. Autopsy disclosed a complex picture of multiple tumour cell emboli in small pulmonary arteries associated with local thrombosis and thrombus-associated vessel wall reaction. This was characterized by movement of medial muscle cells into the thrombus. In addition, affected vessels showed a prominent perivascular tumour-related infiltration by lymphocytes which are identified immunohistochemically as CD3-reactive T-cells.
Bohle
W
W
Department of Pathology, University of Freiburg, Germany.
Schaefer
H E
HE
D000368:Aged; D001344:Autopsy; D017252:CD3 Complex / Q000032:analysis / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D004692:Endarteritis / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D011655:Pulmonary Embolism / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D017252:CD3 Complex