Prognostic factors in large-cell lymphomas.
A review of the most significant prognostic factors found in large cell lymphomas is presented. Prognostic factors are divided in four categories: (a) those related to the patient: age at diagnosis; (b) those related to the tumor: stage, tumor bulk, spreading of tumor, extranodal sites, LDH and beta 2-microglobulin levels; (c) those related to the host-tumor relationship: performance status, presence of B symptoms, serum albumin level, and interleukin secretion; and (d) those related to the physicians: type of treatment, dose intensity of this treatment. Most of these parameters are related to each others and only a few of them keep statistically significant correlation with outcome in multiparametric studies. New prospective studies with new therapeutic strategies should stratify patients before treatment on these most important prognostic factors.
Coiffier
B
B
Hematology Service, Hospices Civils de Lyon, France.
Lepage
E
E
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000401:mortality*; D008875:Middle Aged; D011379:Prognosis
D007770:L-Lactate Dehydrogenase