title: Immunogenetics of familial rheumatoid arthritis: a study of 41 multicase families.
abstract: HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (chi 2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.
authors: Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.
authors: V
authors: V
authors: Taneja
authors: N K
authors: NK
authors: Mehra
authors: R R
authors: RR
authors: Singh
authors: C
authors: C
authors: Anand
authors: A N
authors: AN
authors: Malaviya
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens