title: Juvenile gigantomastia: report of a case.
abstract: Juvenile gigantomastia in a 12-year-old girl was treated by a bilateral reduction mammoplasty with free transplantation of the areolae and nipples and the removal of 3,980 g of breast tissue. Regrowth of the residual breast tissue has been suppressed by the administration of tamoxifen, an antiestrogen drug, since the surgery. This case was positive for estrogen receptors (ER) by the dextran-coated charcoal method, while tissue staining for ER and estradiol resulted in a darker staining of the epithelial contents, especially of fibroadenoma-like nodules, using an immunocytochemical assay. It is thus suggested that the etiology of this disease might be related to a local hypersensitivity to estrogen.
authors: School of Medicine Science, University of Tokushima, Japan.
authors: T
authors: T
authors: Morimoto
authors: K
authors: K
authors: Komaki
authors: T
authors: T
authors: Mori
authors: M
authors: M
authors: Sasa
authors: H
authors: H
authors: Miki
authors: H
authors: H
authors: Inoue
authors: Y
authors: Y
authors: Monden
authors: H
authors: H
authors: Nakanishi
mesh_terms: D001941:Breast Diseases / Q000378:metabolism* / Q000601:surgery; D002648:Child; D066246:ErbB Receptors / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D007150:Immunohistochemistry; D016462:Mammaplasty; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol; D066246:ErbB Receptors