Comparison of taurine, alpha-tocopherol, retinol, selenium, and total triglycerides and cholesterol concentrations in cats with cardiac disease and in healthy cats.
Epidemiologic relations were evaluated between plasma concentrations of nutrients and cardiovascular diseases. A total of 220 cats were assessed: 144 cats with noninduced acquired heart disease and 76 clinically normal cats. Plasma was assayed for taurine, alpha-tocopherol, selenium, retinol, and total cholesterol and triglycerides concentrations. Cardiovascular disease groups included dilated cardiomyopathy (n = 53), left ventricular hypertrophy (n = 28), hyperthyroidism (n = 11), and uncertain classification (n = 52). In cats with dilated cardiomyopathy, mean plasma taurine concentration was the lowest of that in cats of any group, being only 38% of the value in healthy cats; females had less than half the mean value of males. Tocopherol concentration was 20% lower than normal, and retinol concentration was 40% higher than normal. Total cholesterol concentration was 36% lower than normal. Triglycerides concentration was higher in these cats than in any other group--twice the value recorded in healthy cats and 67% higher than that in hyperthyroid cats. In cats with hypertrophic cardiomyopathy, almost 15% had mean plasma taurine concentration < 30 mumol/L. Retinol concentration was 15% higher, and triglycerides concentration was 54% higher than normal. Approximately 27% of hyperthyroid cats had mildly decreased plasma taurine concentration. Hyperthyroid cats had the lowest tocopherol and cholesterol values; both were at least 30% lower than normal. Retinol concentration was 30% higher than normal. Approximately 14% of cats with uncertain classification had mildly decreased plasma taurine concentration. Plasma retinol and triglycerides concentrations were higher than normal in 25 and 38% of these cats, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Fox
P R
PR
Department of Medicine, Animal Medical Center, New York, NY 10021.
Trautwein
E A
EA
Hayes
K C
KC
Bond
B R
BR
Sisson
D D
DD
Moise
N S
NS
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000662:veterinary; D002318:Cardiovascular Diseases / Q000097:blood / Q000662:veterinary*; D002371:Cat Diseases / Q000097:blood*; D002415:Cats / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006980:Hyperthyroidism / Q000097:blood / Q000662:veterinary; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000662:veterinary; D008297:Male; D012016:Reference Values; D012643:Selenium / Q000097:blood; D012737:Sex Factors; D013654:Taurine / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
D014280:Triglycerides; D014801:Vitamin A; D014810:Vitamin E; D013654:Taurine; D002784:Cholesterol; D012643:Selenium