The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain.
1. Using positron emission tomography and 11C-N-methylspiperone and 11C- SCH23390, dopamine D1 and D2 receptors, and serotonin 5-HT2 receptors in human brain were evaluated in living healthy age different subjects. 2. Dynamic analysis of PET data indicated that these receptor binding abilities decreased with aging in healthy humans.
Iyo
M
M
Division of Clinical Research, National Institute of Radiological Sciences, Chiba, Japan.
Yamasaki
T
T
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001552:Benzazepines / Q000378:metabolism; D001923:Brain Chemistry / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000031:analogs & derivatives / Q000378:metabolism; D014055:Tomography, Emission-Computed
D001552:Benzazepines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D013134:Spiperone; C039167:3-N-methylspiperone