[Disodium pamidronate (APD) in the treatment of bone metastases].
Diphosphonates are potent inhibitors of bone resorption, they have been evaluated in several clinical trials for bone metastases. We performed a clinical study to evaluate the therapeutic effect of Disodium Pamidronate over pain and radiologic evolution in bone metastases (Breast Cancer and Multiple Myeloma patients). The results regarding the first 10 patients concluded that there is good drug tolerability and significant analgesic activity in 6 patients, with sclerosis of lytic skull lesions in one breast cancer patient.
Costa
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L
Serviço de Medicina I, Hospital de Santa Maria, Lisboa.
Moreira
C
C
da Costa
E B
EB
D000328:Adult; D001859:Bone Neoplasms / Q000150:complications* / Q000209:etiology / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D000077268:Pamidronate
D004164:Diphosphonates; D000077268:Pamidronate
Pamidronato dissódico (APD) no tratamento das metástases ósseas.