title: Penetration of fusidic acid into human brain tissue and cerebrospinal fluid.
abstract: Penetration of fusidic acid into brain tissue in six patients and cerebrospinal fluid in seven patients was determined. Tissue samples, taken during surgery revealed drug levels at about 7% of simultaneous serum concentrations. In contrast, cerebrospinal fluid concentrations were below 1% of serum levels. Since serum- and tissue levels of fusidic acid were far above the minimal inhibitory concentration (MICs) of staphylococci and streptococci, and since it has a long serum half-life of about 10 hours, it is a promising candidate for prophylaxis in neurosurgery.
authors: Neurochirurgische Universitätsklinik, Kantonsspital Basel, Switzerland.
authors: T
authors: T
authors: Mindermann
authors: W
authors: W
authors: Zimmerli
authors: Z
authors: Z
authors: Rajacic
authors: O
authors: O
authors: Gratzl
mesh_terms: D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D001927:Brain Diseases / Q000097:blood / Q000601:surgery*; D001932:Brain Neoplasms / Q000097:blood / Q000601:surgery; D002540:Cerebral Cortex / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000097:blood / Q000517:prevention & control*
chemical_list: D005672:Fusidic Acid