Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase.
Palbinone, a novel terpenoid isolated from the roots of Paeonia albiflora, showed a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol. The structures of palbinone and a known compound, paeonilactone-B isolated from the active fraction of this plant were determined by the use of 2D NMR techniques (1H-1H COSY, 1H-13C COSY, 1H-13C long-range COSY, and HMBC).
Kadota
S
S
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Terashima
S
S
Basnet
P
P
Kikuchi
T
T
Namba
T
T
D042842:11-beta-Hydroxysteroid Dehydrogenases; D006913:Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
D013729:Terpenes; C080910:palbinone; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases