Steroid metabolism with intestinal microorganisms.
As a result of the metabolic activities of numerous anaerobic microorganisms with sterols, bile acids and steroid hormones as substrates in connection with the enterohepatic circulation of these compounds, the intestine may be considered as an "endocrine" active site or organ. The review summarizes transformations of steroids by anaerobic intestinal bacteria, the physiological and supposed pathophysiological meaning thereof. The aim is to recommend further investigation in this field with respect to both the elucidation of the reactions and biological responses.
Groh
H
H
Jenaer Beutenberg-Institute, Wissenschaftler-Integrations-Programm der KAI e.V. Berlin, Jena, Germany.
Schade
K
K
Hörhold-Schubert
C
C
D000818:Animals; D001421:Bacteria, Anaerobic / Q000378:metabolism*; D001439:Bacteroides / Q000378:metabolism; D001711:Biotransformation; D003013:Clostridium / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D005051:Eubacterium / Q000378:metabolism; D006801:Humans; D006865:Hydrogenation; D006868:Hydrolysis; D006900:Hydroxylation; D007422:Intestines / Q000382:microbiology*; D013256:Steroids / Q000493:pharmacokinetics*
D013256:Steroids