The influence of lorazepam medication upon the transfer properties of the brain during sleep in man.
In order to get better insight into the principles of information processing by the brain during sleep and its alterations under the influence of drugs we applied some tools from linear system theory to sleep EEG data. We investigated late components of auditory and visually evoked potentials (AEPs and VEPs) during different sleep stages and calculated from these the so-called amplitude-frequency characteristics (AFC). The main advantage of this analysis is that it enables one to detect functional differences during different sleep stages. This information can hardly be obtained by conventional spectral analysis. The result of our investigation was that the transfer properties of the brain during sleep were extremely different and that lorazepam medication not only resulted in quantitative alterations of the sleep profile but mainly in highly significant alterations of the functional properties of sleep.
Röschke
J
J
Department of Psychiatry, University of Mainz, Germany.
Wagner
P
P
Aldenhoff
J B
JB
D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D010775:Photic Stimulation; D017286:Polysomnography; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000187:drug effects*
D008140:Lorazepam