title: Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.
abstract: UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.
authors: Department of Medicine, McGill University, Montréal, Québec, Canada.
authors: H H
authors: HH
authors: van Es
authors: A
authors: A
authors: Bout
authors: J
authors: J
authors: Liu
authors: L
authors: L
authors: Anderson
authors: A M
authors: AM
authors: Duncan
authors: P
authors: P
authors: Bosma
authors: R
authors: R
authors: Oude Elferink
authors: P L
authors: PL
authors: Jansen
authors: J R
authors: JR
authors: Chowdhury
authors: E
authors: E
authors: Schurr
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization
chemical_list: D014453:Glucuronosyltransferase