title: Sister chromatid exchange in Waldenström's macroglobulinemia.
abstract: Results on sister chromatid exchange (SCE) frequency and interchromosomal distribution in bone marrow and peripheral blood cultures from patients with Waldenström's macroglobulinemia are reported. PHA-stimulated bone marrow cultures showed increased SCE frequencies in all 12 patients examined. The increase was particularly high in two cases (17.07 and 16.77 SCE/cell, respectively) and, in one of them, a very high SCE level was found in PHA-stimulated peripheral blood culture (40.81 SCE/cell). In LPS-stimulated cultures, increased SCE levels were observed in some patients. Comparison between SCE frequency in bone marrow cell cultures with either mitogen showed a significant increase in PHA-stimulated cultures. Analysis of the interchromosomal SCE distribution revealed significant differences with respect to the control values; however, these differences were variable in the different patients. In pooled data of PHA-stimulated bone marrow cultures, there were differences between expected and observed SCEs in chromosomes 1 and 2 and in B, E, F, and G chromosome groups. Results of cell cycle modifications are also reported.
authors: Dipartimento di Biologia Cellulare e dello Sviluppo A. Monroy, Università di Palermo, Italy.
authors: P
authors: P
authors: Carbone
authors: F
authors: F
authors: Caradonna
authors: G
authors: G
authors: Granata
authors: G
authors: G
authors: Barbata
mesh_terms: D000328:Adult; D000368:Aged; D002453:Cell Cycle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012854:Sister Chromatid Exchange; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics*