Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig.
The i.v. bolus application of 1 nmol/kg endothelin-1 (ET-1) in anaesthetized and ventilated guinea-pigs caused an increase in mean arterial blood pressure (BP) and a bronchoconstriction. Both have been reduced or abolished by COX inhibition (ASA) or substances specifically reducing the thromboxane A2 (TXA2) generation (HOE 944) or receptor binding (BM 13177). The significant increase in TXB2 concentrations in plasma and bronchoalveolar lavage (BAL) after ET-1 challenge (15-fold and 4-fold, respectively) have been reduced or abolished by ASA as well as HOE 944 and not altered by BM 13177.
Lueddeckens
G
G
Martin Luther University Halle-Wittenberg, School of Medicine, Department of Pharmacology and Toxicology, Germany.
Bigl
H
H
Sperling
J
J
Becker
K
K
Braquet
P
P
Förster
W
W
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D016084:Bronchoconstriction / Q000187:drug effects* / Q000502:physiology; D016232:Endothelins / Q000494:pharmacology*; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors; D013449:Sulfonamides / Q000494:pharmacology; D013928:Thromboxane A2 / Q000378:metabolism*; D013929:Thromboxane B2 / Q000097:blood / Q000378:metabolism; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors; D014667:Vasopressins / Q000502:physiology
D016232:Endothelins; D007093:Imidazoles; D009281:Naphthalenes; D017482:Receptors, Thromboxane; D013449:Sulfonamides; C059526:6-(5-methylimidazol-1-yl)methyl-2-naphthoic acid hydrochloride; D014667:Vasopressins; D013929:Thromboxane B2; D013928:Thromboxane A2; C040624:sulotroban; D011451:Prostaglandin-Endoperoxide Synthases; D013930:Thromboxane-A Synthase; D001241:Aspirin