title: Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick.
abstract: The effects of feeding Fusarium moniliforme culture material, containing known concentrations of fumonisin B1 (FB1), were studied in broiler chicks. Day-old chicks were allotted randomly to dietary treatments containing 0, 1.02, 2.04, 3.06, 4.08, 5.10, 6.12, and 7.14% fumonisin culture material (FCM). These levels of FCM supplied 0, 75, 150, 225, 300, 375, 450, and 525 mg of FB1/kg of feed. Each dietary treatment was fed to four pen replicates of six birds each for 21 days. Chicks fed FCM that supplied 450 and 525 mg FB1/kg diet had lower (P < .05) feed intakes and BW gains; increased (P < .05) liver and kidney weights; and increased (P < .05) mean cell hemoglobin, and mean cell hemoglobin concentrations. Compared with controls, chicks fed FCM had increased (P < .05) free sphinganine levels and sphinganine:sphingosine ratios. Treatment-associated histological lesions were only observed in the liver of chicks fed diets containing FCM that supplied 225 mg FB1/kg or higher. Diets containing FCM that supplied levels as low as 75 mg FB1/kg affected the physiology of chicks by increasing free sphinganine levels and sphinganine:sphingosine ratios. Because inhibition of sphingolipid biosynthesis has been hypothesized as the mechanism of action of FB1, this suggests that diets containing 75 mg FB1/kg FCM may be toxic to young broiler chicks.
authors: Department of Animal Sciences, College of Veterinary Medicine, University of Missouri, Columbia 65211.
authors: T S
authors: TS
authors: Weibking
authors: D R
authors: DR
authors: Ledoux
authors: A J
authors: AJ
authors: Bermudez
authors: J R
authors: JR
authors: Turk
authors: G E
authors: GE
authors: Rottinghaus
authors: E
authors: E
authors: Wang
authors: A H
authors: AH
authors: Merrill
mesh_terms: D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D002274:Carcinogens, Environmental / Q000633:toxicity*; D002645:Chickens; D005247:Feeding Behavior; D005260:Female; D037341:Fumonisins; D005670:Fusarium / Q000254:growth & development*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006965:Hyperplasia; D007958:Leukocyte Count / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D009183:Mycotoxins / Q000633:toxicity*; D009336:Necrosis; D009929:Organ Size / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D002274:Carcinogens, Environmental; D037341:Fumonisins; D006454:Hemoglobins; D009183:Mycotoxins; C056933:fumonisin B1