title: Evaluation of brain function in acute carbon monoxide poisoning with multimodality evoked potentials.
abstract: The median nerve somatosensory evoked potentials (SEP), pattern reversal visual evoked potentials (VEP), and brain stem auditory evoked potentials (BAEP) were studied in 109 healthy adults and in 88 patients with acute carbon monoxide (CO) poisoning. The upper limits for normal values of peak and interpeak latencies of multimodalities of evoked potentials in the reference group were established by a stepwise multiple regression analysis. SEP changes selectively affecting N32 and N60 were found in 78.8% of patients. There was prolonged P100 latency of VEP in 58.2% of the cases examined. The prevalence of BAEP abnormalities in comatose patients (36%) was significantly higher than that (8.6%) in conscious patients. BAEP abnormalities were most frequently seen in comatose patients who had diminished brain stem reflexes (77.8%). It has been found that a consistent abnormality involving N20 and subsequent peaks in SEP, a remarkable prolongation of P100 latency in VEP, or a prolongation of III-V interpeak latency in BAEP as well as the reoccurrence of evoked potential abnormalities after initial recovery all indicate unfavorable outcomes in patients with acute CO poisoning. The multimodality evoked potentials have proved to be sensitive indicators in the evaluation of brain dysfunction and in the prediction of prognosis of acute CO poisoning and the development of delayed encephalopathy.
authors: Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
authors: F
authors: F
authors: He
authors: X
authors: X
authors: Liu
authors: S
authors: S
authors: Yang
authors: S
authors: S
authors: Zhang
authors: G
authors: G
authors: Xu
authors: G
authors: G
authors: Fang
authors: X
authors: X
authors: Pan
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology; D002249:Carbon Monoxide Poisoning / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis