title: Chicken eggshell porphyrins and the glyoxalase pathway: its possible physiological role.
abstract: 1. The plasma 4,5-dioxovaleric acid (DOVA) levels of two different breeds of chicken were determined and found to be higher in the group with a higher porphyrin eggshell content. 2. The erythrocyte and uterus glyoxalase II activity, investigated by means of a new spectrophotometric method, was found to be significantly higher in the group with a low porphyrin eggshell content. 3. A comparative genetic study of two chicken populations, one with white and one with dark eggshells, showed different gene frequencies for the glyoxalase I polymorphism. 4. An interpretation of these data suggests that the glyoxalase pathway may be involved in the metabolism of early porphyrin precursors.
authors: Department of Chemical Pathology, University of Pretoria, South Africa.
authors: R
authors: R
authors: van Brummelen
authors: S
authors: S
authors: Bissbort
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics; D004528:Egg Shell / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005787:Gene Frequency; D007791:Lactoylglutathione Lyase / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011166:Porphyrins / Q000378:metabolism*; D013053:Spectrophotometry; D013869:Thiolester Hydrolases / Q000235:genetics / Q000378:metabolism*; D014599:Uterus / Q000201:enzymology; D014631:Valerates / Q000097:blood; D000099301:Hydroxyacylglutathione Hydrolase
chemical_list: D007791:Lactoylglutathione Lyase; D011166:Porphyrins; D013869:Thiolester Hydrolases; D014631:Valerates; D000099301:Hydroxyacylglutathione Hydrolase; C007509:4,5-dioxovaleric acid