Biocompatibility of polyoxymethylene (Delrin) in bone.
The bone tissue reaction to bulk polyoxymethylene (Delrin) was studied in eight adult albino rabbits followed for up to 5 months after insertion of implants into the tibial metaphyses. Each animal received two implants, one of pure Delrin, the other a 'mosaic' plug with alternating areas of commercially pure titanium and Delrin. At the passage through the cortex, a direct bone-Delrin contact was seen in more than half of the cases, but the contact was usually limited in extent. At the same time, in virtually all sections, a foreign-body reaction with macrophages and giant cells was prominent. It was concluded that bulk Delrin has inferior biocompatibility to titanium, and the advisability of using Delrin as a biomaterial for bone anchorage is questionable.
Ohlin
A
A
Department of Orthopaedic Surgery, Malmö General Hospital, Sweden.
Linder
L
L
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D001842:Bone and Bones; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology*; D015726:Giant Cells; D008264:Macrophages; D008297:Male; D016348:Osseointegration; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D012117:Resins, Synthetic / Q000009:adverse effects; D013977:Tibia
D001672:Biocompatible Materials; D012117:Resins, Synthetic; C010102:delrin