[Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study].
BACKGROUND
Among travellers to distant countries with a low socioeconomic status and poor hygiene, traveller's diarrhea is a major problem. Once this epidemiological fact had been recognized, intensive efforts were made to reduce the incidence of this illness by prophylactic medication. Among non-antibiotic substances investigated, Saccharomyces boulardii (SB) appeared to show promising results in earlier studies.


METHODS
In a placebo-controlled, double-blind study, various dosages (250 mg and 1,000 mg SB) were administered prophylactically to 3,000 Austrian travellers to distant regions.


RESULTS
A significant reduction in the incidence of diarrhea was observed, with success depending directly on the rigorous use of the preparation. A tendency was noted for SB to have a varying regional effect, which was particularly marked in North Africa and in the Near-east (Turkey!); in addition, the effect also proved to be dose-dependent. The medication can be classified as low on side effects.
Kollaritsch
H
H
Institut für Spezifische Prophylaxe und Tropenmedizin, Universität Wien.
Holst
H
H
Grobara
P
P
Wiedermann
G
G
D000328:Adult; D003906:Developing Countries; D003967:Diarrhea / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012959:Socioeconomic Factors; D014195:Travel; D015002:Yeast, Dried / Q000008:administration & dosage*
C009786:perenterol
Prophylaxe der Reisediarrhöe mit Saccharomyces boulardii. Ergebnisse einer plazebokontrollierten Doppelblindstudie.