[The microcirculatory dynamics of prostaglandin E1 and/or nicardipine and their different reactions in the hyper- and hypodynamic state of septic shock in a rat model].
The reactions of the mesenteric microcirculation dynamics to prostaglandin E1(PGE1) and nicardipine were investigated under continuous biomicroscopy with a high speed video analyzer in septic shock models using rats. Both of the drugs induced similar reactions. In the hyperdynamic state, the vasodilation and increasing velocity of red blood cells (RBC) stimulated by both of these vasodilators were similar to those in normal control state. However, in the hypodynamic state the vasodilators especially PGE1 had little effect on increasing the velocity of RBC in spite of their vasodilating action. Therefore these vasodilators are useful in order to improve the microcirculatory blood flow in states such as early septic-shock state.
Takakura
K
K
Department of Anesthesiology & Reanimatology, Fukui Medical School.
Sugiura
Y
Y
Nakajima
K
K
Goto
Y
Y
D000527:Alprostadil / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D009529:Nicardipine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000188:drug therapy / Q000503:physiopathology*; D013152:Splanchnic Circulation / Q000187:drug effects*
D009529:Nicardipine; D000527:Alprostadil