title: The combination of hydroxyurea and leucapheresis in the treatment of chronic myeloid leukaemia in pregnancy.
abstract: Treatment of malignancy during pregnancy is difficult because of the potential teratogenicity of chemotherapeutic agents. Leucapheresis was employed in the initial management of a pregnant patient with chronic myeloid leukaemia. It was subsequently replaced with oral hydroxyurea during the second trimester. Successful delivery of a live male infant was achieved and the child has normal growth and development to date.
authors: Department of Haematology, St. James's Hospital, Dublin, Republic of Ireland.
authors: J M
authors: JM
authors: Fitzgerald
authors: S R
authors: SR
authors: McCann
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use; D015994:Incidence; D007231:Infant, Newborn; D007370:Interferon Type I / Q000627:therapeutic use; D007937:Leukapheresis; D007938:Leukemia / Q000453:epidemiology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D011256:Pregnancy Outcome; D011994:Recombinant Proteins
chemical_list: D007155:Immunologic Factors; D007370:Interferon Type I; D011994:Recombinant Proteins; D006918:Hydroxyurea