Yersinia associated arthritis in SHR rats: effect of the microbial status of the host.
Following the intravenous injection of live Yersinia enterocolitica O:8, 50-69% of SHR rats developed arthritis; these rats were antibody free against all rat pathogens tested. In contrast, only 20-25% of SHR rats which had serum antibodies against Bacillus piliformis, Kilham rat virus, and Toolan H-1 virus developed arthritis. The results indicate that the microbial load of the host has a profound effect on the susceptibility to experimental arthritis.
Gripenberg-Lerche
C
C
Department of Medical Microbiology, Turku University, Finland.
Toivanen
P
P
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D016918:Arthritis, Reactive / Q000382:microbiology*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000382:microbiology*; D013045:Species Specificity; D014777:Virus Diseases / Q000382:microbiology; D015009:Yersinia Infections / Q000276:immunology / Q000382:microbiology*
D000907:Antibodies, Bacterial