Effects of gastrin-releasing peptide and analogues on guinea pig nasal mucosal secretion.
The effects of gastrin-releasing peptide (GRP), bombesin, GRP-(1-16) and GRP-(21-27) on guinea pig nasal mucosal secretion were studied in vivo. GRP, bombesin, and GRP-(21-27) induced significant secretion of total protein, albumin, and alkaline phosphatase. GRP induced significant secretion at lower concentrations (10(-11) and 10(-10) M) than were required for bombesin and GRP-(21-27) (10(-7) M). GRP-(1-16) did not stimulate secretion, indicating that the COOH-terminal region of GRP contained the secretagogic principle. Capsaicin, a stimulant of nociceptive sensory nerves, stimulated GRP release into nasal secretions. These data suggest that GRP is present in guinea pig nasal mucosa and that the COOH-terminal region of GRP may regulate mucosal macromolecule secretion.
Gawin
A Z
AZ
Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Baraniuk
J N
JN
Lundgren
J D
JD
Kaliner
M
M
D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019886:Gastrin-Releasing Peptide; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
D005768:Gastrointestinal Hormones; D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D011506:Proteins; C080749:gastrin releasing peptide (1-16); C080748:gastrin releasing peptide (21-27); D019886:Gastrin-Releasing Peptide; D001839:Bombesin