title: d-alpha-Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells.
abstract: Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.
authors: Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
authors: N K
authors: NK
authors: Ozer
authors: P
authors: P
authors: Palozza
authors: D
authors: D
authors: Boscoboinik
authors: A
authors: A
authors: Azzi
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002463:Cell Membrane Permeability; D006801:Humans; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000201:enzymology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D008077:Lipoproteins, LDL; D014810:Vitamin E; D011493:Protein Kinase C