The influence of picrotoxin on the methylation of phospholipids of the olfactory cortex of the brain of rats.
It was demonstrated that a decrease in the intensity of methylation of phosphatidylethanolamine in sections of rat olfactory cortex is observed 15 min following the introduction of picrotoxin (10(-5) M) into the incubation medium. The decrease in the intensity of methylation of phospholipids may be closely linked to the opening of ion channels, since it is known that maximal depolarization of the membranes is observed during this period of the effect of the preparation.
Gerasimova
I A
IA
Laboratory of the Regulation of Functions of Brain Neurons, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, Leningrad.
Emel'yanov
M A
MA
Mokrushin
A A
AA
Pavlinova
L I
LI
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008745:Methylation; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012436:S-Adenosylmethionine / Q000494:pharmacology
D010714:Phosphatidylethanolamines; D010852:Picrotoxin; D012436:S-Adenosylmethionine