Ceruletide therapy in action tremor following thalamic hemorrhage.
Two men, aged 63 and 71 years, developed a gross action tremor and dysesthesias several months after an intracerebral hemorrhage. CT and MRI showed a small hemorrhage in the posterior region of the lateral nucleus of the thalamus in each patient. The tremor occurred on movement, had frequencies of 2.5-4.5 Hz and the amplitude varied depending on the joint position of the limb. Ceruletide (a cholecystokinin analog) 0.8 micrograms/kg i.m. produced a marked reduction in the action tremor and improved motor function. This effect appeared 10-15 min after the injection, and lasted for up to 4 weeks. It is suggested that ceruletide may be of value in the treatment of action tremors following a thalamic lesion.
Mano
Y
Y
Department of Neurology, Nara Medical University, Japan.
Nakamuro
T
T
Takayanagi
T
T
Mayer
R F
RF
D000368:Aged; D002543:Cerebral Hemorrhage / Q000150:complications*; D002108:Ceruletide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013787:Thalamic Nuclei; D014202:Tremor / Q000188:drug therapy* / Q000209:etiology
D002108:Ceruletide