Pituitary as a target organ for toxic effects of P4501A1 inducing chemicals.
We report here that cytochrome P4501A1 in the male rainbow trout pituitary is highly inducible by beta-naphthoflavone. Pituitary cells containing inducible P4501A1 were identified by double immunostaining as gonadotrophs containing gonadotropin II. Thus, the pituitary gonadotrophs may be target cells for polyaromatic hydrocarbons. Elevated plasma levels of gonadotropin II (GTH II) and testosterone in the induced fish indicated that the functioning of the pituitary was disturbed. Because GTH II regulate the final stage of sexual maturation the results implies that exposure to P4501A1 inducing compounds may disturb this development stage.
Andersson
T
T
Department of Zoophysiology, University of Göteborg, Sweden.
Förlin
L
L
Olsen
S
S
Fostier
A
A
Breton
B
B
D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology* / Q000633:toxicity; D015153:Blotting, Western; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006062:Gonadotropins / Q000097:blood; D008297:Male; D010088:Oxidoreductases / Q000096:biosynthesis*; D010902:Pituitary Gland / Q000201:enzymology*; D012741:Sexual Maturation; D013739:Testosterone / Q000097:blood; D014337:Trout / Q000378:metabolism*; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D006062:Gonadotropins; D013739:Testosterone; D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D019363:Cytochrome P-450 CYP1A1