Toxicological and immune findings in workers exposed to pentachlorophenol (PCP).
Pentachlorophenol (PCP) is a pesticide used worldwide in industrial and domestic applications. Data available on the effects of technical-grade PCP on the immune system are insufficient and equivocal; some data indicate inhibitory effects, whereas others suggest stimulating effects. This study was performed to evaluate toxicological and immune findings in 32 subjects who had prolonged exposure to PCP in a wood factory and in 37 controls. PCP concentrations were determined in plasma and urine of all subjects. Lymphocyte subsets of CD3-, CD4-, and CD8-positive cells were evaluated, and the proliferative response of peripheral blood mononuclear cells (PBM) to mitogens was assessed. The results suggested the absence of major laboratory and clinical signs of PCP-dependent immune deficiency. A weak effect of long-term exposure to PCP on the functional immune response could not be ruled out because of the finding of a decreased response to 5% PHA in the high-exposure group. A weak effect against hepatocyte membrane was evidenced by the finding of raised serum concentration of glycocholic, taurodeoxycholic, and glycochenodeoxycholic acids in subjects directly exposed to PCP for more than 10 y.
Colosio
C
C
Institute of Occupational Health, University of Milan, Italy.
Maroni
M
M
Barcellini
W
W
Meroni
P
P
Alcini
D
D
Colombi
A
A
Cavallo
D
D
Foa
V
V
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects; D001647:Bile Acids and Salts / Q000097:blood; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007136:Immunoglobulins / Q000097:blood / Q000187:drug effects; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D010416:Pentachlorophenol / Q000009:adverse effects* / Q000032:analysis / Q000276:immunology*; D014934:Wood
D001323:Autoantibodies; D001647:Bile Acids and Salts; D007136:Immunoglobulins; D010416:Pentachlorophenol