Induction of c-Fos-like protein in the lateral habenular nucleus by persistent noxious peripheral stimulation.
Persistent noxious peripheral stimulation by formalin injection into the unilateral hindpad of anaesthetized rats induced c-Fos-like protein immunoreactivity (c-Fos-LI) in neurons within the lateral habenular nucleus (LHb) bilaterally. Formalin injection after the transection of spinal cords also induced c-Fos-LI in many neurons within the LHb, though the number of labeled cells changed depending on the post-transection period. These results suggest that the LHb modulates nociceptive information, but that it receives nociceptive information via extraspinal pathways as well as intraspinal ascending noxious pathways.
Nagao
M
M
Department of Neurology, University of Kyoto, Japan.
Kamo
H
H
Akiguchi
I
I
Kimura
J
J
D000818:Animals; D003655:Decerebrate State / Q000503:physiopathology; D005557:Formaldehyde / Q000494:pharmacology; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D013268:Stimulation, Chemical; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos; D005557:Formaldehyde