A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin.
1. The participation of cholinergic and gamma amino butyric acid (GABA) neurotransmitter systems in the anti-nociceptive effect of gossypin was investigated using pharmacological tools. 2. Physostigmine potentiated its anti-nociceptive response while atropine failed to modify it significantly. 3. THIP (4,5,6,7-tetra hydroisoxazolo (5,4-C) pyridin-3-ol) and gossypin treatment produced an additive response while bicuculline attenuated the anti-nociceptive response of gossypin. Similar observations were recorded for morphine. 4. It is suggested that cholinergic and GABAergic systems play a role in gossypin-induced anti-nociception.
Viswanathan
S
S
Medicinal Chemistry Research Centre, Madras Medical College, India.
Thirugnanasambantham
P
P
Ramaswamy
S
S
Bapna
J S
JS
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010277:Parasympathomimetics / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000700:Analgesics; D005419:Flavonoids; D007555:Isoxazoles; D010277:Parasympathomimetics; D005680:gamma-Aminobutyric Acid; D009020:Morphine; C022944:gossypin; C015542:gaboxadol