title: The role of lipid peroxidation and calcium in galactosamine induced toxicity in the rat liver.
abstract: Liver homogenate and subcellular fractional levels of lipid peroxides, homogenate glutathione (GSH) and calcium contents and hepatic plasma membrane Ca(2+)-ATPase activity were determined in rats, 12, 18, 24 and 48 hours after treatment with a single dose of 1 g/kg galactosamine. Lipid peroxides and calcium levels in liver homogenate and subcellular fractions were found to increase, but hepatic GSH content and Ca(2+)-ATPase activity were observed to decrease reversibly.
authors: Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
authors: S
authors: S
authors: Seçkin
authors: N
authors: N
authors: Koçak-Toker
authors: M
authors: M
authors: Uysal
authors: B
authors: B
authors: Oz
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005688:Galactosamine / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008315:Malondialdehyde; D005688:Galactosamine; D000252:Calcium-Transporting ATPases; D005978:Glutathione; D002118:Calcium