Spastic quadriplegia in Western Australia. II: Pedigrees and family patterns of birthweight and gestational age.
Pedigrees were obtained for all 74 index children and for three controls for each case. Recurrence of similar spastic quadriplegic phenotypes occurred in two families. A karyotype of 46,XY,dup(13)(q14q34), resulting in a partial trisomy 13, was found in another case. Rates of miscarriages and stillbirths plus neonatal deaths were higher among siblings of index cases than in siblings of birth-year controls, but were similar to siblings of birthweight controls. Average birthweights and gestational ages were lower in index cases than in birth-year controls. Children with spastic quadriplegia had significantly lower birthweights and gestational ages than their siblings. However, they also tended to come from families with a pattern of low birthweight and preterm delivery. The differences between families remained after controlling for factors affecting birthweight.
Petterson
B
B
Department of Anatomy and Human Biology, University of Western Australia.
Stanley
F J
FJ
Garner
B J
BJ
D001315:Australia / Q000453:epidemiology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D005192:Family Health; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D009128:Muscle Spasticity; D010375:Pedigree; D011247:Pregnancy; D011782:Quadriplegia / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D014314:Trisomy / Q000235:genetics