Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease.
Three children with homozygous sickle cell disease, 22 months and 8 and 10 years of age, had clinical and hematologic manifestations of aplastic and splenic sequestration crisis simultaneously. They had an acute drop in hemoglobin level (16, 20, and 45 gm/L), reticulocytopenia (0.1%, 0.6%, and 0.3%), and sudden splenic enlargement. Evidence of recent parvovirus infection was demonstrated.
Mallouh
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Specialty Medical Services Department, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia.
Qudah
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D000741:Anemia, Aplastic / Q000382:microbiology*; D000755:Anemia, Sickle Cell / Q000235:genetics / Q000382:microbiology*; D002648:Child; D016731:Erythema Infectiosum / Q000150:complications*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006720:Homozygote; D006801:Humans; D007223:Infant; D008297:Male; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D012156:Reticulocytes; D013163:Splenomegaly / Q000382:microbiology*
D006454:Hemoglobins