title: In vitro cytotoxic activity of an N-hydroxypyridine-2-thione derivative.
abstract: The in vitro antitumor activity of N-(1-adamantoyloxy)pyridine-2-thione (APT), an N-hydroxypyridine-2-thione derivative, was investigated against a panel of both murine and human tumor cell lines growing in vitro. To evaluate the cytotoxic activity of APT the MTT ((4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) in vitro assay was used, which is considered to have predictive value for drug chemosensitivity evaluation. The results demonstrate that APT has antitumor activity, thus confirming theoretical suppositions about its cytoreductive potential.
authors: Institute of Medical Pharmacology, University of Perugia, Italy.
authors: E
authors: E
authors: Lepri
authors: E
authors: E
authors: Castagnino
authors: L
authors: L
authors: Binaglia
authors: A
authors: A
authors: Giampietri
authors: S
authors: S
authors: Corsano
authors: M C
authors: MC
authors: Fioretti
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*; D013871:Thiones / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D013871:Thiones; C081029:N-(1-adamantoyloxy)pyridine-2-thione