title: Long-term results and biocompatibility of heparin-surface-modified intraocular lenses.
abstract: A prospective in vivo study of 50 intraocular lenses was done to document the long-term results and biocompatibility of heparin-surface-modified poly(methyl methacrylate) posterior chamber lenses. Continuous curvilinear capsulorhexis and phacoemulsification were performed throughout and examinations were by slit-lamp and specular microscopy. Decentrations of more than 1 mm were seen in 4% of eyes. Stress folds from the haptic traction forces were detected in 16%. A posterior capsulotomy was performed in 10% because of fibrosis or Elschnig pearl formation. Fine fibers were found on the lens surface in 76%. During the first postoperative days only a moderate number of fibroblast-like cells was observed. Foreign-body giant cells were seen in 8%. All cases with foreign-body giant cells had posterior synechias. Visual performance and clinical results were comparable to those of other well-approved intraocular lenses. The low percentage of cellular reaction on the lens surface suggests good biocompatibility.
authors: 1. Universität Augenklinik Wien, Vienna, Austria.
authors: M
authors: M
authors: Amon
authors: R
authors: R
authors: Menapace
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials; D002387:Cataract Extraction; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005549:Foreign-Body Reaction / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D006493:Heparin; D006801:Humans; D007910:Lenses, Intraocular; D008137:Longitudinal Studies; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D008875:Middle Aged; D011446:Prospective Studies; D011474:Prosthesis Design; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D001672:Biocompatible Materials; D008768:Methylmethacrylates; D020366:Methylmethacrylate; D006493:Heparin