Novel sequences conserved on the human and mouse X chromosomes.
We have cloned and mapped 28 single-copy probes from a pool of cosmids derived from the human X chromosome. Four of the probes detected strongly conserved sequences in murine DNA; all have been localized to the proximal region of the human X chromosome short arm. Comparative mapping of these sequences in the mouse genome demonstrates that, while X linkage is conserved, this region of the human X chromosome is not maintained as a contiguous segment on the mouse X chromosome. The mapping of one novel conserved sequence between Plp and Pdha1 on the mouse X chromosome defines a previously unknown region of homology. The mapping of another probe that detects a novel sequence family (DXF34) close to the X chromosome centromere in both species suggests that a block of pericentromeric material is conserved between the X chromosomes of man and mouse.
Laval
S H
SH
Genetics Division, MRC Radiobiology Unit, Chilton, Didcot, Oxon, United Kingdom.
Boyd
Y
Y
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D017124:Conserved Sequence; D003433:Crosses, Genetic; D005260:Female; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014960:X Chromosome