title: Cerebrovascular NADPH diaphorase-containing nerve fibers in the rat.
abstract: Recently, neuronal nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase has been elucidated to be the nitric oxide synthase (NOS) per se. In order to examine the existence and distribution of cerebrovascular nerve fibers containing these substances, NADPH-diaphorase histochemistry was applied to the cerebral blood vessels and the cranial ganglia known to innervate the cerebral vessels in the rat. Numerous nerve fibers with varicosities forming plexuses were observed in the circle of Willis and its branches. In addition, thick nerve bundles were seen to run along the wall of the internal ethmoidal artery. NADPH-diaphorase reaction was prominent in neurons of the sphenopalatine, otic and internal carotid ganglia. This study demonstrated, for the first time, the NADPH-diaphorase-containing nerve fibers in the cerebral vessels and ganglion cells in the parasympathetic and sensory ganglia known to innervate the cerebral vessels.
authors: Department of Neurology, Keio University, Tokyo, Japan.
authors: N
authors: N
authors: Suzuki
authors: Y
authors: Y
authors: Fukuuchi
authors: A
authors: A
authors: Koto
authors: Y
authors: Y
authors: Naganuma
authors: K
authors: K
authors: Isozumi
authors: S
authors: S
authors: Matsuoka
authors: J
authors: J
authors: Gotoh
authors: T
authors: T
authors: Shimizu
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000201:enzymology / Q000294:innervation; D001921:Brain / Q000166:cytology* / Q000201:enzymology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002941:Circle of Willis / Q000201:enzymology; D005724:Ganglia / Q000166:cytology / Q000201:enzymology; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000201:enzymology; D006651:Histocytochemistry; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009412:Nerve Fibers / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014278:Trigeminal Nuclei / Q000166:cytology / Q000201:enzymology
chemical_list: D009252:NADPH Dehydrogenase