[The radioprotective effect of GABA-tropic substances, gamma-hydroxybutyrate and piracetam].
From experiments in mice, it is shown that with a radiation dose of 8 Gy (LD96) the radioprotective effect was exerted by gamma-aminobutyric acid (GABA), substances that increase its concentration in tissues (progabide and valproate), and synthetic agonists of both receptor types, particularly baclofen, a GABA-receptor agonist. The radioprotective effect is also exerted by gamma-hydroxybutyrate, not piracetam.
Kulinskiĭ
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Klimova
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D000818:Animals; D016009:Chi-Square Distribution; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010889:Piracetam / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012978:Sodium Oxybate / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000528:radiation effects*
D011837:Radiation-Protective Agents; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D010889:Piracetam
Issledovanie radiozashchitnogo éffekta GAMK-tropnykh veshchestv, gamma-gidroksibutirata i piratsetama.