Determination of thiol-containing drugs by chemiluminescence-flow injection analysis.
A flow injection analysis procedure with chemiluminescence detection for the determination of both thiol-containing drugs and the amino acid cysteine is described. Procedures are based on the inhibition by the drugs of the chemiluminescence generated in the copper-catalysed oxidation of luminol by hydrogen peroxide. The proposed methods were applied to the determination of cysteine, N-acetylcysteine, penicillamine, 2-mercaptopropionylglycine and thiouracil in pharmaceuticals.
Viñas
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P
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
Lopez Garcia
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Martinez Gil
J A
JA
D000111:Acetylcysteine / Q000032:analysis; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003545:Cysteine / Q000032:analysis; D017022:Flow Injection Analysis; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008163:Luminescent Measurements; D008165:Luminol / Q000737:chemistry; D010396:Penicillamine / Q000032:analysis; D013438:Sulfhydryl Compounds / Q000032:analysis*; D008625:Tiopronin / Q000032:analysis
D013438:Sulfhydryl Compounds; D008165:Luminol; D003300:Copper; D006861:Hydrogen Peroxide; D008625:Tiopronin; D010396:Penicillamine; D003545:Cysteine; D000111:Acetylcysteine