title: Extending the limits of lung cancer resection.
abstract: Patients with locally advanced bronchogenic carcinoma are often considered to have unresectable disease because of invasion into vital structures, or they undergo resection with questionable or involved margins, which results in local recurrence later. Brachytherapy (direct application of radioactive sources to the tumor bed) offers the potential to provide tumoricidal doses of radiation to the target area with minimal toxicity to surrounding structures. In this study, one of two different techniques of brachytherapy was utilized to treat 15 highly selected patients with histologically positive (n = 8) or suspicious (n = 7) margins after resection. The techniques were easy to apply and were not associated with any complications directly related to their use. One postoperative death resulted from a perforated peptic ulcer. In the remaining 14 patients, at a mean follow-up of 38 months, local control was complete in 12 (86%) patients, and 8 patients are alive, with 7 free of disease. Thoracic brachytherapy may offer the potential for cure to patients whose disease would otherwise be considered inoperable.
authors: Department of Surgery, Swedish Hospital Medical Center, Seattle, Washington.
authors: R W
authors: RW
authors: Aye
authors: T P
authors: TP
authors: Mate
authors: H N
authors: HN
authors: Anderson
authors: L P
authors: LP
authors: Johnson
authors: L
authors: L
authors: Hill
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D002283:Carcinoma, Bronchogenic / Q000532:radiotherapy* / Q000601:surgery; D002813:Chondrosarcoma / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007432:Intraoperative Period; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care; D011879:Radiotherapy Dosage
chemical_list: D007457:Iodine Radioisotopes; D007496:Iridium Radioisotopes