[Modification of maximal binding capacity and radio-T3/T4 distribution by carbamazepine and diclofenac].
Marked changes in plasma thyroid function parameters due to medication have been described in literature. We, therefore, studied the influence of routine administration of carbamazepine and diclofenac upon the radio T3/T4 distribution to specific thyroid transport proteins as well as their maximal binding capacity (MBC) for T4. Both drugs have been found to lead to changes in T3 and T4 distribution but not to any influence upon MBC. The parameters of thyroid function mostly revealed reduced FT3 and FT4 values while bTSH was affected only by carbamazepine administration.
Sternad
H
H
Internen Abteilung, Krankenhauses der Barmherzigen Brüder Graz-Eggenberg.
Albrecher
B
B
Langsteger
W
W
Eber
O
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002220:Carbamazepine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004008:Diclofenac / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000378:metabolism*; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood*; D013975:Thyroxine-Binding Proteins / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood*
D011228:Prealbumin; D012709:Serum Albumin; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D004008:Diclofenac; D002220:Carbamazepine; D013972:Thyrotropin; D013974:Thyroxine
Beeinflussung der maximalen Bindungskapazität und der Radio-T3/T4-Verteilungen durch Carbamazepin und Diclofenac.