[The independent variability of different karyotypic characteristics during the spontaneous neoplastic evolution of mouse embryo fibroblasts].
The dynamics of some karyotype characteristics throughout the spontaneous neoplastic evolution of embryonal fibroblasts of different mouse strains was studied using a differential staining of chromosomes. The independent variability of chromosome modal numbers, the number of polyploid cells in the cell line, the number of chromosomal rearrangements within one cell, the activity of formation of different types of chromosomal rearrangements and the activity of interactions of the homologous chromosomes in 15 studied cell lines were revealed. Possible levels of variability regulations of different karyotype characteristics are discussed.
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D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure*; D002478:Cells, Cultured / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000648:ultrastructure; D014644:Genetic Variation; D007621:Karyotyping; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011123:Polyploidy
Nezavisimaia izmenchivost' razlichnykh kariotipicheskikh kharakteristik v protsesse spontannoĭ neoplasticheskoĭ évoliutsii émbrional'nykh fibroblastov mysheĭ.