A prototype erodible mask delivery system for the excimer laser.
OBJECTIVE
The authors developed an erodible mask delivery system for the argon-fluoride 193-nm excimer laser, which offers the possibility of correcting hyperopia and astigmatism as well as myopia.


METHODS
Masks were made of polymethylmethacrylate on a quartz window, with intended corrections for myopia and hyperopia of 2.5 and 5 diopters (D). Ablations using the mask and control ablations using an expanding diaphragm were performed in 30 eyes of 15 pigmented rabbits with an Excimed UV200 laser (Summit Technology, Inc, Waltham, MA). The rabbits were followed for 134 days with regular biomicroscopy and retinoscopic examination by two observers.


RESULTS
Ablations with the mask to correct myopia were successful and produced stable corrections, although the higher-power mask produced undercorrections. Hyperopic masks produced paradoxic myopic corrections, possibly due to the lack of a transition zone at the edge of the mask. Corneas ablated with the mask had less sub-epithelial haze than those ablated with the diaphragm at all examinations. Results of histopathologic examination showed epithelial hyperplasia over the ablation zone in all eyes. Dichlorotriazinyl aminofluorescein collagen staining showed subepithelial new collagen in all eyes, but there was no relation between the depth of ablation at any point on the cornea and the amount of new collagen deposited there.


CONCLUSIONS
Myopic ablations are feasible with the erodible mask, although additional calibration is needed. Hyperopic ablations were unsuccessful with the current design. Corneas ablated with the mask may be clearer than corneas ablated with the diaphragm, possibly due to a smoother ablated surface. Regression of effect after laser ablation in the rabbit model is likely due more to epithelial hyperplasia than to stromal remodeling.
Maloney
R K
RK
Emory University, Department of Ophthalmology, Atlanta, GA 30322.
Friedman
M
M
Harmon
T
T
Hayward
M
M
Hagen
K
K
Gailitis
R P
RP
Waring
G O
GO
D000818:Animals; D003315:Cornea / Q000473:pathology; D005452:Fluoresceins; D005500:Follow-Up Studies; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods*; D008397:Masks; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D008856:Microscopy, Fluorescence; D009216:Myopia / Q000473:pathology / Q000601:surgery*; D009885:Ophthalmology / Q000295:instrumentation; D011817:Rabbits; D014945:Wound Healing
D005452:Fluoresceins; D008768:Methylmethacrylates; D020366:Methylmethacrylate; C039083:5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)fluorescein