Reverse mismatch between perfusion and aerosol ventilation in transplanted lungs.
Thirty ventilation-perfusion pulmonary scintigraphic studies were performed in 13 patients who had undergone unilateral lung transplantation. Ventilation-perfusion mismatch (ventilation better than perfusion) was judged absent, mild, moderate, or severe in the transplanted and native lungs. Ventilation-perfusion mismatch was significantly worse in the transplanted lungs (p < .0001). Findings of lung biopsies and chest roentgenograms failed to correlate with the severity of ventilation-perfusion mismatch. Hypoxic pulmonary vasoconstriction appears to be significantly impaired in most unilateral lung transplants; the mechanism for this impairment is unclear.
Kuni
C C
CC
Department of Radiology, University of Minnesota Hospital and Clinic, Minneapolis 55455.
Ducret
R P
RP
Nakhleh
R E
RE
Boudreau
R J
RJ
D000328:Adult; D000336:Aerosols; D001706:Biopsy; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology / Q000502:physiology; D016040:Lung Transplantation / Q000000981:diagnostic imaging* / Q000473:pathology / Q000502:physiology; D008297:Male; D011667:Pulmonary Veins / Q000503:physiopathology; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D016284:Technetium Tc 99m Pentetate; D014661:Vasoconstriction / Q000502:physiology; D014692:Ventilation-Perfusion Ratio / Q000502:physiology
D000336:Aerosols; D016284:Technetium Tc 99m Pentetate