title: Ketoconazole administration in hypercortisolemic depression.
abstract: Ketoconazole, an antiglucocorticoid drug, was administered to 10 hypercortisolemic depressed patients for up to 6 weeks. Three patients dropped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cortisol levels and in depression ratings. Antiglucocorticoid agents may be useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.
authors: Department of Psychiatry, University of California, San Francisco.
authors: O M
authors: OM
authors: Wolkowitz
authors: V I
authors: VI
authors: Reus
authors: F
authors: F
authors: Manfredi
authors: J
authors: J
authors: Ingbar
authors: L
authors: L
authors: Brizendine
authors: H
authors: H
authors: Weingartner
mesh_terms: D000328:Adult; D000368:Aged; D003864:Depression, Chemical; D003866:Depressive Disorder / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000502:physiology; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index
chemical_list: D007654:Ketoconazole; D006854:Hydrocortisone