title: Pulmonary pseudolymphoma presented with a mass lesion in a patient with primary Sjögren's syndrome: beneficial effect of intermittent intravenous cyclophosphamide.
abstract: A 61-year-old woman with primary Sjögren's syndrome (SS) presented with fever, dry cough, dyspnea on exertion, and a mass lesion with reticular shadowing at both bases on her chest X-ray. Pulmonary pseudolymphoma was diagnosed by transbronchial lung biopsy which revealed infiltration of T cell-like slightly atypical lymphoid cells. After three infusions of cyclophosphamide (750 mg every 4 weeks) combined with prednisolone, the pulmonary mass lesion was diminished and her symptoms improved. Evaluation of the 12 reported cases of pulmonary pseudolymphoma with SS that presented with mass lesions showed an increase in IgM level, frequent pulmonary fibrosis, precedence of SS, and better prognosis with immunosuppressants in those patients.
authors: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors: K
authors: K
authors: Tsuzaka
authors: H
authors: H
authors: Akama
authors: H
authors: H
authors: Yamada
authors: M
authors: M
authors: Akizuki
authors: T
authors: T
authors: Tojo
authors: M
authors: M
authors: Homma
mesh_terms: D001706:Biopsy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D013902:Radiography, Thoracic; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D003520:Cyclophosphamide