[Participation of non-major histocompatibility complex gene in experimental autoimmune uveitis].
It is known that the susceptibility of experimental autoimmune uveitis (EAU) is controlled by both major histocompatibility antigen complex (MHC) and non-MHC genes. In this report, we studied the role of non-MHC gene in the induction of EAU. LEW, WKAH, (LEW x WKAH) F1 and (LEW x WKAH) F2 rats were examined for their incidence and severity to develop EAU by immunization with bovine S-antigen (S-Ag). We found that all LEW rats developed severe EAU within 2 weeks after immunization, but no WKAH rat did. Most F1 rats developed mild inflammation in 3-4 weeks after immunization. A quarter of F2 rats developed EAU within 2 weeks, half of them developed it in 3-6 weeks after immunization, and the others did not. These findings suggest that only one non-MHC gene controls the susceptibility to S-Ag induced EAU in rats.
Yoshikawa
K
K
Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan.
Hirose
S
S
Sasamoto
Y
Y
Kotake
S
S
Matsuda
H
H
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics*; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D014605:Uveitis / Q000235:genetics* / Q000276:immunology
D006649:Histocompatibility Antigens