Nifedipine attenuates the hypertensive response to tracheal intubation in pregnancy-induced hypertension.
Thirty women with pregnancy-induced hypertension (PIH) scheduled for Caesarean section under general anaesthesia were studied to evaluate the efficacy of sublingual nifedipine in attenuating the pressor response to laryngoscopy and tracheal intubation. The patients were randomly given either the contents of a nifedipine capsule 10 mg or placebo sublingually 20 min before induction of anaesthesia. Blood pressure and heart rate were recorded at various time intervals. There was a decrease in mean arterial blood pressure (MAP) after pretreatment with nifedipine (P < 0.01). The increase in MAP during laryngoscopy and intubation was higher in the control group compared with nifedipine pretreatment group (P < 0.01). During laryngoscopy and intubation, MAP decreased by 3 mmHg in the nifedipine pretreatment group, while there was an increase of 14 mmHg in the control group. Heart rate increased in both the groups during the laryngoscopy and tracheal intubation (P < 0.01) but the increase was higher in the nifedipine group than in the control group (P < 0.05). Neonatal Apgar scores in both the groups were comparable. These results suggest that sublingual nifedipine is effective in attenuating the hypertensive response to laryngoscopy and intubation but not the tachycardiac response in parturients with PIH.
Kumar
N
N
Department of Anaesthesiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Batra
Y K
YK
Bala
I
I
Gopalan
S
S
D000286:Administration, Sublingual; D000328:Adult; D000771:Anesthesia, Intravenous; D001034:Apgar Score; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects*; D002585:Cesarean Section; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000517:prevention & control; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007828:Laryngoscopy / Q000009:adverse effects*; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D013874:Thiopental; D013997:Time Factors
D010919:Placebos; D009543:Nifedipine; D013874:Thiopental