Simultaneous measurements of twenty-four-hour whole-body retention of 47Ca-chloride and 99mTc-MDP: early differentiation of metabolic bone diseases in rat models.
The 24-h whole-body retention (24-h WBR) of 47Ca-chloride and 99mTc-MDP was measured in four rat models over a 6-week period at 2 week intervals. Fine detail bone radiographs of the femurs and histologic bone specimens were also obtained simultaneously. In the osteomalacic (M) and steroid-induced osteoporotic (S) groups the 24-h WBR values of 47Ca were significantly lower, and in the osteoporotic (P) group were higher than in the control (C) group from the second week. The 24-h WBR values of 99mTc-MDP were significantly higher in the M group and were lower in the S group from the second week. Simultaneous measurements of 24-h WBR of these two radiopharmaceuticals facilitated the early differentiation of metabolic bone diseases in the animal models prior to the detection of radiologic bone changes.
Seto
H
H
Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Ihara
F
F
Futatsuya
R
R
Kamei
T
T
Kakishita
M
M
Noda
M
M
D000818:Animals; D001345:Autoradiography; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002122:Calcium Chloride / Q000493:pharmacokinetics*; D002132:Calcium Radioisotopes; D004195:Disease Models, Animal; D008297:Male; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D012588:Scintillation Counting; D013669:Technetium Tc 99m Medronate
D002132:Calcium Radioisotopes; D002122:Calcium Chloride; D013669:Technetium Tc 99m Medronate