Effects of vitamin E on cadmium-induced locomotor dysfunctions in rats.
The effect of co-administration of vitamin E (VE) on cadmium (Cd)-induced locomotor deficits in growing rats was investigated. Intraperitoneal administration of 0.4 mg Cd/kg/d for 4 w resulted in significant decreases in time of ambulation and stereotype and numbers of stereotypic and vertical movements, but the resting time was enhanced. Administration of VE (5 mg alpha - tocopherol acetate/kg im on alternate days) to these rats effectively antagonised these locomotor deficits. The data support the hypothesis that Cd may induce oxidative stress in the CNS and that treatment with an antioxidant may be beneficial against such damage.
Ali
M M
MM
Neurotoxicology Division, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Shukla
G S
GS
Srivastava
R S
RS
Mathur
N
N
Chandra
S V
SV
D000818:Animals; D001921:Brain / Q000378:metabolism; D002104:Cadmium / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics / Q000633:toxicity; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology*
D002104:Cadmium; D014810:Vitamin E