Seizures due to lidocaine toxicity in a child during cardiac catheterization.
A 17-month-old boy developed grand mal seizures secondary to lidocaine toxicity during balloon dilatation of a congenital pulmonary valve stenosis. Lidocaine at 38 mg/kg (nine times the recommended maximum dose of 4.5 mg/kg) was administered during a 90-min period in order to optimize local anesthesia. This resulted in toxic serum lidocaine levels (8.7 mg/L; therapeutic range, 1.5-5 mg/L) at the time of seizures. Caution should be exercised with local anesthetics during invasive cardiac catheterizations. Hypercarbia (which lowers the seizure threshold to local anesthetics) should be avoided and the temptation to exceed the maximum recommended dose resisted.
Ryan
C A
CA
Pediatric Intensive Care Unit, University of Alberta Hospitals, University of Alberta, Edmonton, Canada.
Robertson
M
M
Coe
J Y
JY
D000772:Anesthesia, Local; D006328:Cardiac Catheterization; D002404:Catheterization; D004305:Dose-Response Relationship, Drug; D004830:Epilepsy, Tonic-Clonic / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D008297:Male; D011666:Pulmonary Valve Stenosis / Q000097:blood / Q000628:therapy*
D008012:Lidocaine