Studies on T. spiralis and T pseudospiralis larvae recovered from mice immunized with heterologous Trichinella antigen.
In this study, S3 antigen of T. spiralis and T. pseudospiralis was given to the heterologous infection in albino mice. The recovered larvae were studied as regards: their number, length and steroscan examination. It was found that vaccination of mice with T. spiralis (S3) antigen induced reduction in T. pseudospiralis larval count by 66.43% and significant reduction in length. Using T. pseudospiralis (S3) antigen reduction of 74.77% in T. spiralis larval count was detected as well as significant reduction in length. Scanning electron microscopic (SEM) examination revealed more or less similar finding in both species: loss of integrity of the cuticle, some of the larvae were attacked by granulocytes mainly eosinophils and few larvae appeared completely destructed with loss of normal architecture. A peculiar finding was noticed in case of T. pseudospiralis larvae in form of fine electron dense deposits giving the cuticular surface a motling appearance.
Boulos
L M
LM
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
Abou Samra
L M
LM
Hegazy
I H
IH
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D007814:Larva / Q000276:immunology / Q000648:ultrastructure; D051379:Mice; D008855:Microscopy, Electron, Scanning; D014234:Trichinella / Q000276:immunology / Q000648:ultrastructure*; D017160:Trichinella spiralis / Q000276:immunology / Q000648:ultrastructure*; D014235:Trichinellosis / Q000469:parasitology* / Q000517:prevention & control; D014611:Vaccination
D000947:Antigens, Helminth