Proton pump inhibitors, enterochromaffin-like cell growth and Helicobacter pylori gastritis.
In both rodents and humans the development of gastrin-promoted gastric argyrophil enterochromaffin-like cell carcinoids requires the involvement of a genetic factor inherent to multiple endocrine neoplasia syndrome or of type A autoimmune chronic atrophic gastritis. Prolonged severe hypergastrinaemia acting on non-gastritic mucosa, as in Zollinger-Ellison syndrome patients, results in diffuse argyrophil enterochromaffin-like cell hyperplasia but, as a rule, does not produce tumours. Combination of chronic atrophic gastritis (mostly related to Helicobacter pylori infection) with hypergastrinaemia frequently causes linear and micronodular hyperplasia of argyrophil cells, whereas carcinoids are exceptional. No tumours or pre-neoplastic lesions have been observed in patients treated long-term with proton pump inhibitors, apart from rare cases in patients with combined Zollinger-Ellison and multiple endocrine neoplasia syndromes. A moderate increase in the incidence of argyrophil cell clustering, with or without hyperplasia, probably results from the parallel evolution of ulcer-associated Helicobacter gastritis into chronic atrophic gastritis. Eradication of H. pylori with a combination of proton pump inhibitors and antibiotics suppresses gastritis and prevents ulcer recurrence.
Solcia
E
E
Department of Human Pathology and Genetics, University of Pavia, Italy.
Villani
L
L
Luinetti
O
O
Fiocca
R
R
D000818:Animals; D002276:Carcinoid Tumor / Q000139:chemically induced / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004759:Enterochromaffin Cells / Q000166:cytology* / Q000187:drug effects; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D017494:Proton Pumps / Q000187:drug effects*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology
D017494:Proton Pumps