Duration-dependent variability in the responses of diabetic rat aorta to noradrenaline and 5-hydroxytryptamine.
1. The responsiveness of isolated aortic rings from 1, 4 and 12 week streptozotocin-induced diabetic rats to noradrenaline (NA) and 5-hydroxytryptamine (5-HT) were compared with those of non-diabetic controls under standard organ bath procedure. 2. There were significant increases in the maximum contractile responses to both agents after 1 and 4 weeks but not after 12 weeks of diabetes mellitus. 3. The variable responses show that duration-dependent functional changes occur in the course of streptozotocin diabetes in rats.
Orie
N N
NN
Department of Physiology, College of Medicine, University of Benin, Nigeria.
Aloamaka
C P
CP
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D002122:Calcium Chloride / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D002122:Calcium Chloride; D002118:Calcium; D009638:Norepinephrine