title: [Prophylactic inhalation of amphotericin B in invasive aspergillosis: a distribution study].
abstract: Invasive pulmonary aspergillosis (IPA) during periods of immunosuppression or prolonged neutropenia is a serious condition with high mortality. Prophylaxis is unsatisfactory because of the low effectiveness of systemic administration of amphotericin B (AMB) and because of its side effects. Prophylactic inhalation of AMB by means of a nebulizing system may be able to reduce the incidence of IPA. Therefore, we studied the distribution of nebulized 99mTc-labeled AMB and estimated its particle size. AMB is homogeneously distributed in the lung and partly deposited in the terminal respiratory unit; it remains there with a half-life of at least 14 h. Therefore, prophylaxis of IPA with AMB nebulized as described can be recommended.
authors: Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow, FRG.
authors: G
authors: G
authors: Barzen
authors: J
authors: J
authors: Beyer
authors: G
authors: G
authors: Farshidfar
authors: W
authors: W
authors: Kramp
authors: W
authors: W
authors: Richter
authors: R
authors: R
authors: Felix
mesh_terms: D000280:Administration, Inhalation; D000666:Amphotericin B / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001228:Aspergillosis / Q000517:prevention & control*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000517:prevention & control*; D010316:Particle Size; D014018:Tissue Distribution
chemical_list: D000666:Amphotericin B
vernacular_title: Prophylaktische Inhalation von Amphotericin B bei invasiver Aspergillose: Verteilungsstudie.