title: Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS).
abstract: Eosinophilia-myalgia syndrome (EMS) is thought to be caused by the intake of contaminated L-tryptophan products. 1,1'-Ethyliden bis[L-tryptophan] (EBT) is one of the contaminants in the L-tryptophan products and is thought to be a possible cause of EMS. In the present study we report that anti-EBT antibodies are generated by immunizing rabbits with the low molecular weight substance, EBT (molecular weight 434). These antibodies may be available tools for elucidating the mechanisms responsible for the outbreak and/or development of EMS.
authors: Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan.
authors: N
authors: N
authors: Kurihara
authors: H
authors: H
authors: Yanagisawa
authors: Z
authors: Z
authors: Jin
authors: O
authors: O
authors: Wada
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001665:Binding Sites; D016603:Eosinophilia-Myalgia Syndrome / Q000139:chemically induced*; D007114:Immunization; D008297:Male; D008970:Molecular Weight; D011817:Rabbits; D012710:Serum Albumin, Bovine; D013056:Spectrophotometry, Ultraviolet; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000276:immunology / Q000633:toxicity
chemical_list: C070372:1,1'-ethylidene bis(tryptophan); D012710:Serum Albumin, Bovine; D014364:Tryptophan