The pulmonary response of white and black adults to six concentrations of ozone.
Many early studies of respiratory responsiveness to ozone (O3) were done on healthy, young, white males. The purpose of this study was to determine whether gender or race differences in O3 response exist among white and black, males and females, and to develop concentration-response curves for each of the gender-race groups. Three hundred seventy-two subjects (n > 90 in each gender-race group), ages 18 to 35 yr, were exposed once for 2.33 h to 0.0 (purified air), 0.12, 0.18, 0.24, 0.30, or 0.40 ppm O3. Each exposure was preceded by baseline pulmonary function tests and a symptom questionnaire. The first 2 h of exposure included alternating 15-min periods of rest and exercise on a motorized treadmill producing a minute ventilation (VE) of 25 L/min/m2 body surface area (BSA). After exposure, subjects completed a set of pulmonary function tests and a symptom questionnaire. Lung function and symptom responses were expressed as percent change from baseline and analyzed using a nonparametric two factor analysis of variance. Three primary variables were analyzed: FEV1, specific airway resistance (SRaw), and cough. Statistical analysis demonstrated no significant differences in response to O3 among the individual gender-race groups. For the group as a whole, changes in the variables FEV1, SRaw, and cough were first noted at 0.12, 0.18, and 0.18 ppm O3, respectively. Adjusted for exercise difference, concentration-response curves for FEV1 and cough among white males were consistent with previous reports (1).
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Clinical Research Branch, U.S. Environmental Protection Agency, Chapel Hill, NC 27599-7315.
McDonnell
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WF
House
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Salaam
S A
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Dewitt
P J
PJ
Butler
S O
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Green
J
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Raggio
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D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D044383:Black People; D001830:Body Surface Area; D003371:Cough / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D010126:Ozone / Q000494:pharmacology*; D015656:Respiratory Mechanics / Q000187:drug effects*; D044465:White People
D010126:Ozone