[PGI2-like activity of the internal mammary artery and the saphenous vein used in coronary bypass surgery].
The best graft in coronary bypass operations is the internal mammary artery as its rate of staying open for long term is better than that of saphenous vein. The prostacyclin-producing capacity of these human blood vessels was studied using platelet aggregation bioassay. The synthesis of prostacyclin-analogous was significant higher in internal mammary artery than that was in saphenous vein (in 10 min of incubation time internal mammary artery: 73.33; saphenous vein: 42.27 pg/mg). Based on our results we conclude that the difference of "prostacyclin-like" activity between artery and vein might play a role, at least partly, in the more successful operations performed with internal mammary artery.
Homolay
P
P
Debreceni Orvostudományi Egyetem, II. sz. Sebészeti Klinika.
Bordánné Jenes
E
E
Takács
E I
EI
Péterffy
A
A
D000328:Adult; D000818:Animals; D001026:Coronary Artery Bypass; D011464:Epoprostenol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000737:chemistry* / Q000637:transplantation; D008875:Middle Aged; D010974:Platelet Aggregation; D051381:Rats; D012501:Saphenous Vein / Q000737:chemistry* / Q000637:transplantation
D011464:Epoprostenol
Coronaria bypass mütéteknél alkalmazott arteria mammaria interna és a vena saphena PGI2-analóg aktivitásának tanulmányozása.