Increased leukocyte adhesiveness/aggregation and tissue leukostasis following surgical trauma.
The purpose of the present study was to document the increased leukocyte adhesiveness/aggregation (LAA) and tissue leukostasis that follow surgical trauma. We found that following major abdominal surgery, the percentage of aggregated leukocytes in the peripheral blood increased from 8.6 +/- 7 to 21.7 +/- 11.5 (p < 0.001), while the respective values for patients undergoing minor surgery were 3.7 +/- 2.4 and 19.7 +/- 7.6% (p < 0.001). The state of LAA was also determined in eight dogs after partial collectomy and four controls. A clear increment in the degree of tissue leukostasis (especially in the spleen, liver and lungs) was noted in the operated as compared to the control animals. In addition, a significant correlation was found between the state of LAA, determined in the venous (p = 0.0004) and arterial (p = 0.002) blood of these animals and the degree of tissue leukostasis. We conclude that a state of increased LAA in the peripheral blood is induced by surgical trauma and that this increased LAA correlates with tissue leukostasis.
Molad
I
I
Department of Internal Medicine D, Beilinson Medical Center, Petah Tiqva, Israel.
Berliner
S
S
Arber
N
N
Kidron
D
D
Sternberg
E
E
Ben-Bassat
M
M
Giler
S
S
Pinkhas
J
J
Aronson
M
M
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002449:Cell Aggregation / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D003082:Colectomy; D004285:Dogs; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007962:Leukocytes / Q000502:physiology*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000473:pathology; D013514:Surgical Procedures, Operative; D013997:Time Factors