title: Taking enzyme kinetics out of control; putting control into regulation.
abstract: The matrix formulation of metabolic control analysis, which states that multiplying the elasticity matrix for any system by the corresponding control matrix yields an identity matrix, can be transformed into a statement that multiplying a matrix expressing internal regulatory properties by a matrix expressing external regulatory properties also yields an identity matrix. This transformation supplies the formal basis for metabolic regulation analysis, and provides the key to determining the control structure of a system without the need to know the exact changes in enzyme activities that are made to measure control coefficients.
authors: Department of Biochemistry, University of Stellenbosch, South Africa.
authors: J H
authors: JH
authors: Hofmeyr
authors: A
authors: A
authors: Cornish-Bowden
authors: J M
authors: JM
authors: Rohwer
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D006706:Homeostasis; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological
chemical_list: D004798:Enzymes