title: Future approaches to vaccine development: single-dose vaccines using controlled-release delivery systems.
abstract: The development of single-dose vaccines, mainly those administered during childhood, which would effectively protect against certain diseases, would be a very important advance towards better immunization coverage and protection against the respective pathogens. Biodegradable polymeric microspheres which are 'programmed' to deliver the antigen when a boost of the immune response is required, may be a possible way of achieving this goal.
authors: M T
authors: MT
authors: Aguado
mesh_terms: D000818:Animals; D003140:Communicable Disease Control; D003692:Delayed-Action Preparations; D006801:Humans; D007115:Immunization Schedule; D008863:Microspheres; D013745:Tetanus Toxoid / Q000008:administration & dosage; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D013745:Tetanus Toxoid; D014612:Vaccines