title: Renal dysplasia, megalocystis, and sirenomelia in four siblings.
abstract: First degree relatives of infants with bilateral renal agenesis or dysplasia have an increased risk of renal abnormalities including renal agenesis. We report a family in which four successive offspring exhibited a previously undescribed combination of congenital lethal renal disorders: bilateral renal dysplasia, megalocystis secondary to urethral obstruction and, sirenomelia with associated renal agenesis.
authors: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
authors: A M
authors: AM
authors: Selig
authors: B
authors: B
authors: Benacerraf
authors: M F
authors: MF
authors: Greene
authors: M F
authors: MF
authors: Garber
authors: D R
authors: DR
authors: Genest
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002675:Child, Preschool; D004480:Ectromelia / Q000235:genetics*; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities*; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D014524:Urethral Obstruction / Q000235:genetics; D001743:Urinary Bladder / Q000002:abnormalities*