Do superantigens play a role in autoimmunity?
Mycoplasma arthritidis produces a typical soluble superantigen (SAg) which shares many characteristics with bacterial toxins and Mouse Mammary Tumor Virus SAg. However, this microbe is associated with an autoimmune-like disorder and this disease may therefore serve as a model to investigate the potential role of a SAg in autoimmune disease pathogenesis.
Posnett
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Cornell University Medical College, New York, NY 10021.
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens; D000942:Antigens, Bacterial; D001168:Arthritis / Q000209:etiology; D015551:Autoimmunity; D006801:Humans; D066298:In Vitro Techniques; D008934:Mitogens / Q000276:immunology; D008969:Molecular Sequence Data; D009174:Mycoplasma / Q000276:immunology; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D018089:Superantigens; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D000942:Antigens, Bacterial; D008934:Mitogens; C052996:Mycoplasma arthritidis mitogen; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens