The functional effects of gadolinium-DTPA on the isolated perfused rat kidney.
Clinical experience suggests that Gd-DTPA has no deleterious effect on renal function. We have evaluated the effects of a large dose (0.6 ml/kg body weight) of this contrast agent on the function of the isolated perfused rat kidney. Gd-DTPA led to a mild, transient increase in glomerular filtration rate with no subsequent fall during the 30 minute observation period. However, Gd-DTPA induced an increase in renal vascular resistance (+ 10%, P < 0.05) as a mild decrease in renal perfusate flow was observed during the experimental phase when compared to that of control kidneys. No significant effect was demonstrated on the fractional excretion of albumin or the fractional reabsorption of sodium. These data support, in an ex vivo experimental model, the clinical experience of the safety of this paramagnetic contrast agent in relation to renal function.
Brown
P W
PW
Department of Diagnostic Imaging, Sheffield Kidney Institute, University of Sheffield, UK.
Haylor
J L
JL
Morcos
S K
SK
el Nahas
A M
AM
D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D005682:Gadolinium / Q000633:toxicity*; D019786:Gadolinium DTPA; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000633:toxicity*; D004369:Pentetic Acid / Q000633:toxicity*; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA