Suppression of macrophage function by suture materials and anastomotic recurrence of Crohn's disease.
After surgical excision of bowel, Crohn's disease is likely to recur around the anastomosis. It is suggested that this may indicate a biological effect of suture materials on gastrointestinal immunology. To investigate this, the influence of six suture materials on the function of macrophages obtained from the rat peritoneal cavity and human intestinal mucosa was assessed. All materials significantly impaired macrophage function.
Scott
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Professorial Surgical Unit, St Bartholomew's Hospital, London, UK.
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Phillips
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D000714:Anastomosis, Surgical; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002478:Cells, Cultured; D003106:Colon / Q000601:surgery; D003424:Crohn Disease / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008264:Macrophages / Q000201:enzymology / Q000502:physiology*; D008297:Male; D009113:Muramidase / Q000378:metabolism; D010587:Phagocytosis; D051381:Rats; D012008:Recurrence; D013537:Sutures
D007770:L-Lactate Dehydrogenase; D009113:Muramidase