[The prevention of congenital developmental anomalies in rats].
Preventive administration of Eleutherococcus XXX extract during prenatal and pre-embryonic periods of development prevents embryotoxic effect of subsequent treatment of pregnant rats with ethanol and sodium salicylate. Eleutherococcus abolishes embryotoxic and teratogenic effects of ethanol manifested against the background of experimental syndrome of iron deficit in pregnant females. Mechanism of its antiteratogenic action is probably based on stimulation of cell detoxification mechanisms, increase in energy potential of cells, as well as on stabilization of structural and functional state of cell membranes.
Gordeĭchuk
T N
TN
Chebotar'
N A
NA
Konopistseva
L A
LA
Puchkov
V F
VF
D015082:2,2'-Dipyridyl / Q000633:toxicity; D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000517:prevention & control; D000435:Alcoholic Intoxication / Q000150:complications / Q000378:metabolism; D000747:Anemia, Hypochromic / Q000139:chemically induced / Q000150:complications / Q000378:metabolism; D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012980:Sodium Salicylate / Q000633:toxicity
D010743:Phospholipids; D010936:Plant Extracts; D015082:2,2'-Dipyridyl; D012980:Sodium Salicylate
Profilaktika vrozhdennykh anomaliĭ razvitiia u krys.