Isradipine and the coronary circulation.
Isradipine has been shown to be an effective vasodilator in different vascular beds. Experimental evidence suggests that isradipine is a potent coronary vasodilator, and this is supported by clinical studies in both cardiology and cardiac surgery. Furthermore, in these studies, coronary vasodilation was not accompanied by evidence of any significant effect on cardiac contractility or conduction. It can be concluded that the cardiac effects of isradipine will ultimately prove to be beneficial in patients undergoing myocardial revascularization.
Feneck
R O
RO
Department of Cardiothoracic Anaesthesia, London Chest Hospital, UK.
Underwood
S M
SM
Walesby
R K
RK
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D017275:Isradipine / Q000627:therapeutic use*
D017275:Isradipine