Molecular characteristics of uronic-acid-rich protein, a strong inhibitor of calcium oxalate crystallization in vitro.
Uronic-acid-rich protein (UAP) is a new urinary macromolecule which strongly inhibits calcium oxalate crystal formation. It is a glycoprotein with a molecular weight of about 35,000 Da, and its carbohydrate content is 8.5%. This inhibitor is composed of two polypeptidic chains crosslinked by chondroitin sulfate. It exhibits partial structural homology with alpha 1-microglobulin. The inhibitory activity seems to be supported by peptidic chains as determined by enzymatic assay.
Atmani
F
F
INSERM Unité 90, Hôpital Necker-Enfants Malades, Paris, France.
Lacour
B
B
Strecker
G
G
Parvy
P
P
Drüeke
T
T
Daudon
M
M
D000595:Amino Acid Sequence; D002129:Calcium Oxalate / Q000737:chemistry*; D003461:Crystallography; D006023:Glycoproteins / Q000737:chemistry / Q000652:urine*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013329:Structure-Activity Relationship; D014574:Uronic Acids / Q000737:chemistry
D006023:Glycoproteins; D014574:Uronic Acids; D002129:Calcium Oxalate