[Krezatsin--a stimulant of the activity of regenerating liver cells].
In experiments with partial hepatectomy in rats, the application of cresacin was shown to potentiate processes of hepatocyte regeneration, to increase high-energy compounds therein, and to accelerate some phases of mitotic cycle. These processes occur along with an inhibition of lipid peroxidation in hepatocytes, a decrease in the rate of transmembrane oxygen transport in mitochondria, and a reduction of cytochrome oxidase amount. It was concluded that cresacin directly stimulates diverse links of metabolic pathway.
Rasulov
M M
MM
Kuznetsov
I G
IG
Belousov
A A
AA
Zabozlaev
A G
AG
Khvylia
S I
SI
Voronkov
M G
MG
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008115:Liver Regeneration / Q000187:drug effects* / Q000502:physiology; D008163:Luminescent Measurements; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013268:Stimulation, Chemical
D000085:Acetates; D004338:Drug Combinations; D004983:Ethanolamines; C047413:crezacin
Krezatsin--stimuliator aktivnosti regeneriruiushchikh kletok pecheni.