title: Response of psoriasis to psoralen-UVB photochemotherapy.
abstract: The effect of psoralen in combination with 311 nm (UVB) radiation was studied in five subjects with normal skin and 10 patients with psoriasis involving both forearms. Treatment with oral 8-methoxypsoralen augmented the UVB erythemal response at 6 h after irradiation, but had no effect at 24-72 h. In eight of the nine patients who completed the trial, lesions of psoriasis on the arms treated with psoralen-UVB cleared before lesions on the arms treated with UVB alone. This study has shown that psoralen in combination with UVB has an erythemal effect on normal skin, and a therapeutic effect in psoriasis which is greater than the response to UVB alone.
authors: Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
authors: A
authors: A
authors: Sakuntabhai
authors: B L
authors: BL
authors: Diffey
authors: P M
authors: PM
authors: Farr
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors
chemical_list: D008730:Methoxsalen