Topical treatment of acute hindlimb lymphedema of the rat using a troxerutin-phosphatidylcholine complex in liposomal-like microdispersion.
A new reversible complex between troxerutin and phosphatidylcholine (85-90mg/kg per day), in the form of a liposome-like water microdispersion, was topically applied to the rat thigh in an experimental counterpart of acute lymphedema. After four days there was 75% less hindlimb edema (mean decrease 40% of normal compared to control 10% of normal) in the treated compared with the untreated rats. These findings suggest that this drug preparation may be useful to minimize acute peripheral lymphedema in patients.
Casley-Smith
J R
JR
Henry Thomas Lab, University of Adelaide, Australia.
Casley-Smith
J R
JR
Curri
S
S
Földi
M
M
D000287:Administration, Topical; D000818:Animals; D004337:Drug Carriers; D006614:Hindlimb; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008081:Liposomes; D008209:Lymphedema / Q000188:drug therapy*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
D004337:Drug Carriers; D006896:Hydroxyethylrutoside; D008081:Liposomes; D010713:Phosphatidylcholines; C005865:troxerutin