High-dose ketamine does not induce c-Fos protein expression in rat hippocampus.
The effects of high-dose ketamine on the c-fos protein (c-Fos) expression were investigated in rat by an immunohistochemical technique. The administration of 100 mg/kg ketamine i.p. induced seizure-like activity (limbic seizure). No c-Fos immunoreactivity was observed in hippocampus, piriform cortex and amygdala, while it was observed in neocortex and thalamus. These findings disagree with the reports that ketamine depresses the neuronal function of the neocortex and thalamus, while it stimulates the limbic system.
Nakao
S
S
Department of Anesthesia, Kyoto University Hospital, Japan.
Arai
T
T
Mori
K
K
Yasuhara
O
O
Tooyama
I
I
Kimura
H
H
D000679:Amygdala / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism
D016760:Proto-Oncogene Proteins c-fos; D016202:N-Methylaspartate; D007649:Ketamine; D007608:Kainic Acid