[An increase in the radioprotective effect of O-methyltyramine and mezaton by monoamine oxidase inhibitors].
Specific 2-propynylamine inhibitors of monoamine oxidase (MAO) pargyline and especially chlorgyline, a selective inhibitor of MAO A (but not deprenyl, a selective inhibitor of MAO B) increase the radioprotective effect of small doses of O-methyltyramine and phenylephrine and do not change the efficacy of large doses. This is consistent with the receptor theory of the mechanism of protective action of amines.
Kulinskiĭ
V I
VI
Gorkin
V Z
VZ
Klimova
A D
AD
Rumiantseva
N P
NP
D000818:Animals; D003010:Clorgyline / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D010293:Pargyline / Q000627:therapeutic use; D010656:Phenylephrine / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012642:Selegiline / Q000627:therapeutic use; D014439:Tyramine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D008996:Monoamine Oxidase Inhibitors; D011837:Radiation-Protective Agents; D010656:Phenylephrine; D012642:Selegiline; D010293:Pargyline; D003010:Clorgyline; C008510:O-methyltyramine; D014439:Tyramine
Uvelichenie ingibitorami monoaminoksidazy radiozashchitnogo éffekta O-metiltiramina i mezatona.