title: Variable rejection patterns of cultured keratinocyte allografts in the rabbit.
abstract: There are many conflicting reports on the survival of cultured keratinocyte allografts (CKAs). Studies were performed in the rabbit model to elucidate further the fate of CKAs. Of 24 CKAs, 7 were identified as technical failures, 13 displayed classical macroscopic evidence of rejection with a prolonged mean survival time of 2.8 days, compared to non-cultured allograft controls (p < 0.01), and 4 failed to display typical macroscopic evidence of rejection. Furthermore, the time to eventual wound healing of the classically rejected CKAs were delayed by 6.0 days (p < 0.0001), compared to identical non-grafted control wounds.
authors: Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia.
authors: A F
authors: AF
authors: Breidahl
authors: R T
authors: RT
authors: Judson
authors: L J
authors: LJ
authors: Dumble
authors: G J
authors: GJ
authors: Clunie
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000473:pathology*; D006085:Graft Survival; D015603:Keratinocytes / Q000637:transplantation*; D011184:Postoperative Period; D011817:Rabbits; D012867:Skin / Q000293:injuries* / Q000473:pathology; D014184:Transplantation, Homologous; D014945:Wound Healing; D014947:Wounds and Injuries / Q000601:surgery