title: The expression of tropomyosin genes in pure cultures of rat neurons, astrocytes and oligodendrocytes is highly cell-type specific and strongly regulated during development.
abstract: Transcripts from the alpha-, beta- and delta-tropomyosin genes were studied during development of pure cultures of rat neurons, astrocytes and oligodendrocytes. The three cell types contained five alpha-tropomyosin messengers, produced using both alternative promoters and splicing; one was specific for mature neurons. The beta-tropomyosin gene is expressed only in astrocytes and the delta-tropomyosin gene in all three cell types, especially in immature cells. Most of the tropomyosin isoforms are highly cell-specific. Their developmental regulation involves either differential expression of genes, in neurons and oligodendrocytes, and/or changes in alternative splicing, in astrocytes, delta-Tropomyosin (TM-4) may be important during the growth of neuronal and glial cell processes, while specialized isoforms such as the neuron-specific alpha-tropomyosin TMBr-3 may be involved in the function or plasticity of the mature cells.
authors: Laboratoire de Neurobiologie Endocrinologique, URA 1197 CNRS, Université Montpellier II, Sciences et Techniques du Languedoc, France.
authors: L
authors: L
authors: Had
authors: C
authors: C
authors: Faivre-Sarrailh
authors: C
authors: C
authors: Legrand
authors: A
authors: A
authors: Rabié
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000378:metabolism*; D001483:Base Sequence; D001921:Brain / Q000166:cytology / Q000196:embryology*; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D005796:Genes; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*; D009928:Organ Specificity; D011401:Promoter Regions, Genetic; D012323:RNA Processing, Post-Transcriptional; D051381:Rats; D014335:Tropomyosin / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins; D014335:Tropomyosin