title: Structure of chicken annexin V at 2.25-A resolution.
abstract: The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 A. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.
authors: Department of Biochemistry and Molecular Biology, University of Leeds, England.
authors: M C
authors: MC
authors: Bewley
authors: C M
authors: CM
authors: Boustead
authors: J H
authors: JH
authors: Walker
authors: D A
authors: DA
authors: Waller
authors: R
authors: R
authors: Huber
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017304:Annexin A5 / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002645:Chickens; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017386:Sequence Homology, Amino Acid; D013816:Thermodynamics; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D017304:Annexin A5; D002118:Calcium