Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus.
Tn551 inactivation of femA, a factor involved in methicillin resistance of Staphylococcus aureus, caused the production of peptidoglycan in which the fraction of monoglycyl- and serine-containing muropeptides was increased at the expense of pentaglycyl muropeptides. femA mutants have a specific block in the biosynthesis of pentaglycine cross bridges after the addition of the first glycine residue.
de Jonge
B L
BL
Rockefeller University, New York, New York 10021.
Sidow
T
T
Chang
Y S
YS
Labischinski
H
H
Berger-Bachi
B
B
Gage
D A
DA
Tomasz
A
A
D000595:Amino Acid Sequence; D002473:Cell Wall / Q000737:chemistry* / Q000378:metabolism; D005798:Genes, Bacterial / Q000235:genetics; D005998:Glycine / Q000032:analysis; D008969:Molecular Sequence Data; D009112:Muramic Acids / Q000737:chemistry* / Q000378:metabolism; D016254:Mutagenesis, Insertional; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D010457:Peptidoglycan / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D012694:Serine / Q000032:analysis; D013211:Staphylococcus aureus / Q000737:chemistry* / Q000235:genetics
D009112:Muramic Acids; D009842:Oligopeptides; D010457:Peptidoglycan; D012694:Serine; D005998:Glycine