title: [Islet of Langerhans transplantation in humans].
abstract: Islet of Langerhans transplantation is an alternative to whole pancreas transplantation for type I diabetic patients, in whom exogenous insulin therapy has not prevented the occurrence of systemic complications. Thanks to a new isolation technique of human islets, 45 patients have been transplanted worldwide since 1988, of whom only 7 have become totally insulin-independent. Rejection and quality of the islet preparations are problems which remain to be solved. Autotransplantation of islets has been proposed in patients undergoing a pancreatectomy for benign disease. The present report concerns two of our patients who had a pancreatectomy with islet autotransplantation. Both patients are insulin-independent 3 and 11 months postoperatively, with satisfactory metabolic tests. Islet autotransplantation can be proposed when pancreatectomy for non-malignant disease is performed. This method may prevent the development of insulin-dependent diabetes, known to be particularly labile. Because of the sophisticated technical procedures required, human islet isolation is at present only performed in a small number of medical centers and still is in the field of medical experimentation.
authors: Département de chirurgie, Hôpital cantonal universitaire de Genève.
authors: P
authors: P
authors: Morel
authors: L
authors: L
authors: Bühler
authors: M
authors: M
authors: Marini
authors: S
authors: S
authors: Deng
authors: R
authors: R
authors: Mage
authors: G
authors: G
authors: Mentha
authors: A
authors: A
authors: Rohner
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005260:Female; D006801:Humans; D007515:Islets of Langerhans / Q000601:surgery; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
vernacular_title: Transplantation d'îlots de langerhans chez l'humain.