title: Bacterial-induced activation of erythrocyte T-antigen complicating necrotising enterocolitis: a case report.
abstract: Erythrocyte Thomsen-Friedenreich crypt antigen (T-antigen) activation is not an uncommon event in infants with severe necrotising enterocolitis (NEC). Transfusion of these infants with blood products containing plasma carries the risk of causing intravascular haemolysis. T-antigen activation is easily detected using a rapid simple lectin agglutination test. Early recognition of T-antigen activation ensures the correct choice of plasma free transfusion therapy. We describe an infant with severe NEC complicated by T-antigen activation and haemolysis.
authors: Department of Paediatrics, University of Western Ontario, London, Canada.
authors: R H
authors: RH
authors: Mupanemunda
authors: C F
authors: CF
authors: Kenyon
authors: M J
authors: MJ
authors: Inwood
authors: K
authors: K
authors: Leigh
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology*; D003016:Clostridium perfringens; D004761:Enterocolitis, Pseudomembranous / Q000276:immunology*; D006461:Hemolysis; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C016467:Thomsen-Friedenreich antigen