[The treatment of infectious endocarditis. Cefotaxime versus "traditional" medical management].
We performed an open study to compare efficacy and renal toxicity of cephotaxime versus the usual beta lactam plus aminoglucoside treatment of infectious endocarditis. Twenty cases were studied, 10 treated with cephotaxime 4 g/day per 21 days and aminoglucoside for only 10 days. Comparison group received a combination of different beta lactam antibiotic plus aminoglucoside for 21 to 50 days, these patients were under care of nonparticipant physicians. Although cephotaxime treatment was as good as conventional antimicrobial scheme for control of infectious endocarditis, the treatment cost increases, and there is only marginal benefit in regard renal toxicity.
Felipe Flores
L
L
Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
León
S
S
Casanova
J M
JM
Reyes
P A
PA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002439:Cefotaxime / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002648:Child; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D002439:Cefotaxime
El tratamiento de la endocarditis infecciosa. Cefotaxima versus manejo médico "tradicional".