The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus.
The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.
Hanratty
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WP
Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406.
Dearolf
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CR
D000818:Animals; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D005816:Genetic Complementation Test; D008297:Male; D009154:Mutation; D009857:Oncogenes; D011995:Recombination, Genetic; D013696:Temperature; D013997:Time Factors