A possible mechanism for increased cerebrovascular permeability in diabetic rats: effects of insulin and 2-deoxy-glucose.
1. Cerebrovascular permeability estimated as Evans blue extravasation significantly increased during insulin-induced hypoglycemia in both non-diabetic and diabetic rat groups. 2. Cerebrovascular permeability also increased significantly during 2-deoxy-glucose-induced intracellular glycopenia in both groups. 3. When a blood glucose level was fixed, cerebrovascular permeability showed no more significant change despite the hyperinsulinemic state in both groups. 4. Results suggest that hypoglycemia and/or intracellular glycopenia seems to be the major factor for increases in cerebrovascular permeability.
Uezu
Y
Y
Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Murakami
K
K
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D003847:Deoxyglucose / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005070:Evans Blue; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007328:Insulin; D005070:Evans Blue; D003847:Deoxyglucose