Cytogenetic evidence of involvement of chromosome regions 15q12 and 12q15 in conditions with associated overgrowth.
Syndromes with associated overgrowth are poorly understood. Besides their mode of inheritance, nothing is known regarding the basic genetic alterations that lead to their abnormal phenotypic manifestations. The chromosome localization of the genes involved remains unknown for this group of syndromes, with the only exception being the Wiedemann-Beckwith syndrome.
Wajntal
A
A
Department of Biology, University of São Paulo, Brazil.
Moretti-Ferreira
D
D
De Souza
D H
DH
Koiffmann
C P
CP
D000015:Abnormalities, Multiple / Q000235:genetics*; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D005260:Female; D006130:Growth Disorders / Q000235:genetics*; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male