[Synthesis of thiazolo[3,2-a]pyridine derivatives and their reactions].
By the reaction of 2-benzoylmethyl-4-methylthiazole (6) with polarized olefins (3, 4) in the presence of base (K2CO3 or NaH), the corresponding thiazolo[3,2-a]pyridine derivatives (7, 8) were obtained. Methylsulfinylthiazolopyridine derivative (11) obtained by the reaction of 8b with m-chloroperbenzoic acid (MCPBA), easily underwent nucleophilic substitution to give the corresponding substituted compounds (10, 12).
Matsuda
Y
Y
School of Pharmaceutical Sciences, Nagasaki University, Japan.
Matsumoto
H
H
Ide
S
S
Furuno
K
K
Torisu
K
K
Itou
T
T
Motokawa
C
C
D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D011725:Pyridines; D014230:Triazoles