Protean causes of myocardial stunning in infants and adults.
Myocardial stunning can follow regional or global ischemia in the adult or immature heart. This report reviews some of our studies of the protean causes of stunning including energy and substrate depletion, inefficient oxygen utilization, calcium loading, acidosis, oxyradical damage, and summarizes studies and strategies to limit its occurrence. Data showing that reintroduction of molecular oxygen during reoxygenation of immature cyanotic hearts can cause stunning via a newly described biochemical pathway involving superoxide anion and nitric oxide are also included.
Buckberg
G D
GD
Department of Surgery, University of California, Los Angeles 90024-1741.
D000328:Adult; D001120:Arginine / Q000502:physiology; D009202:Cardiomyopathies / Q000378:metabolism / Q000503:physiopathology*; D005609:Free Radicals; D006801:Humans; D007223:Infant; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology*; D016276:Ventricular Function / Q000502:physiology
D005609:Free Radicals; D009569:Nitric Oxide; D001120:Arginine