Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil.
We examined the effects of treatment with basic fibroblast growth factor (b-FGF) on hippocampal CA1 neuronal damage following 3 min of forebrain ischemia in the gerbil. Continuous infusion of b-FGF (24 or 240 ng/day over 4 days) using an implanted osmotic minipump into the lateral ventricle prevented CA1 neuronal damage in a dose-dependent manner.
Nakata
N
N
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kato
H
H
Kogure
K
K
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects*; D015918:Infusion Pumps, Implantable; D007276:Injections, Intraventricular; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D016548:Prosencephalon / Q000098:blood supply*
D016222:Fibroblast Growth Factor 2