title: Effects of tibolone on serum concentrations of lipoprotein(a) in postmenopausal women.
abstract: OBJECTIVE
  To evaluate the effects of tibolone (Org OD14), a synthetic steroid used for the relief of postmenopausal symptoms, on serum concentrations of lipoprotein(a) (Lp(a)), an independent risk marker for coronary heart disease.
  
  
  METHODS
  Subset of women participating in a non-randomized prospective trial of tibolone therapy. Twenty-seven women requesting relief of menopausal symptoms were treated with tibolone 2.5 mg/day for six months; 27 women who did not request treatment acted as controls.
  
  
  RESULTS
  Tibolone induced a substantial fall (p < 0.001) in serum Lp(a) levels (median change -48%, range -100% to +3%).
  
  
  CONCLUSIONS
  In terms of cardiovascular risk, the ability of tibolone to lower serum concentrations of Lp(a) may be advantageous in view of the unwanted reduction in high density lipoprotein concentrations which has previously been demonstrated in users of this steroid.
authors: Division of Obstetrics and Gynaecology, United Guy's Medical and Dental School, London, UK.
authors: J
authors: J
authors: Rymer
authors: D
authors: D
authors: Crook
authors: M
authors: M
authors: Sidhu
authors: M
authors: M
authors: Chapman
authors: J C
authors: JC
authors: Stevenson
mesh_terms: D045930:Anabolic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008593:Menopause / Q000097:blood / Q000187:drug effects*; D008875:Middle Aged; D009652:Norpregnenes / Q000494:pharmacology*; D011446:Prospective Studies; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D045930:Anabolic Agents; D017270:Lipoprotein(a); D009652:Norpregnenes; D014280:Triglycerides; D002784:Cholesterol; C027385:tibolone