Oxidized LDL and atherogenesis: relation to risk factors for coronary heart disease.
According to a new theory, a critical step in atherogenesis is oxidation of low-density lipoprotein (LDL) within the arterial wall. Direct data supporting this theory are limited, but indirect evidence suggests that oxidized LDL plays a role in atherogenesis. An important question is whether the LDL-oxidation hypothesis conforms to what is known about other risk factors for coronary heart disease (CHD), such as hypertension, smoking, low high-density lipoprotein (HDL) levels, and diabetes mellitus. Perhaps a unified theory of atherogenesis could be formulated if these risk factors exert their atherogenic actions in part by promoting, facilitating, or permitting the oxidation of LDL.
Grundy
S M
SM
Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9052.
D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood; D015227:Lipid Peroxidation / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D011973:Receptors, LDL / Q000502:physiology; D012307:Risk Factors
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D002784:Cholesterol