Coronary risk factors in children of parents with premature coronary artery disease.
In order to assess the value of family history of premature coronary artery disease as a criterion for coronary risk factor screening, a group of 53 children with such a family history was selected. We determined various coronary risk factors in these children in comparison to 33 controls. Statistically significant differences were observed in apoprotein concentrations but not in concentrations of lipids, lipoproteins or glucose, or in blood pressure or body mass index. The ratio between apoprotein B and apoprotein AI was the best discriminator between the two groups. The predictive value of family history is more reliable for detecting abnormal apoprotein ratio than for detection of hypercholesterolemia. We conclude that if abnormal apoprotein levels during childhood are found to be a valued predictor of premature coronary artery disease, then family history of premature coronary artery disease can be used to select children for determination and assessment of their coronary risk.
Beigel
Y
Y
Department of Internal Medicine, Beilinson Medical Center, Petah Tiqva, Israel.
George
J
J
Leibovici
L
L
Mattityahu
A
A
Sclarovsky
S
S
Blieden
L
L
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016632:Apolipoprotein A-I / Q000032:analysis; D001055:Apolipoproteins B / Q000097:blood; D002648:Child; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D011237:Predictive Value of Tests; D012307:Risk Factors
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B