Decreased bone mineral density in HLA-B27 positive members of a family with osteogenesis imperfecta.
We describe a family in which several members had osteogenesis imperfecta (OI) and/or were positive for HLA-B27. The proband, who had ankylosing spondylitis and OI, had severe osteoporosis with fractures continuing to occur in the late teens. Bone mineral density measurements in 5 family members and the proband, revealed more severe osteoporosis in those with positive HLA-B27.
Escalante
A
A
Arthritis Service of the Rancho Los Amigos Medical Center, Downey, CA.
Beardmore
T D
TD
D000293:Adolescent; D000328:Adult; D015519:Bone Density / Q000235:genetics* / Q000276:immunology*; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000235:genetics* / Q000276:immunology; D010024:Osteoporosis / Q000150:complications; D010375:Pedigree; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000235:genetics* / Q000276:immunology
D015796:HLA-B27 Antigen