title: Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus.
abstract: Tn551 inactivation of femA, a factor involved in methicillin resistance of Staphylococcus aureus, caused the production of peptidoglycan in which the fraction of monoglycyl- and serine-containing muropeptides was increased at the expense of pentaglycyl muropeptides. femA mutants have a specific block in the biosynthesis of pentaglycine cross bridges after the addition of the first glycine residue.
authors: Rockefeller University, New York, New York 10021.
authors: B L
authors: BL
authors: de Jonge
authors: T
authors: T
authors: Sidow
authors: Y S
authors: YS
authors: Chang
authors: H
authors: H
authors: Labischinski
authors: B
authors: B
authors: Berger-Bachi
authors: D A
authors: DA
authors: Gage
authors: A
authors: A
authors: Tomasz
mesh_terms: D000595:Amino Acid Sequence; D002473:Cell Wall / Q000737:chemistry* / Q000378:metabolism; D005798:Genes, Bacterial / Q000235:genetics; D005998:Glycine / Q000032:analysis; D008969:Molecular Sequence Data; D009112:Muramic Acids / Q000737:chemistry* / Q000378:metabolism; D016254:Mutagenesis, Insertional; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D010457:Peptidoglycan / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D012694:Serine / Q000032:analysis; D013211:Staphylococcus aureus / Q000737:chemistry* / Q000235:genetics
chemical_list: D009112:Muramic Acids; D009842:Oligopeptides; D010457:Peptidoglycan; D012694:Serine; D005998:Glycine