title: The effect of chlorothiazide on bone-related biochemical variables in normal post-menopausal women.
abstract: OBJECTIVE
  To evaluate the effects of short-term administration of chlorothiazide on fasting urinary hydroxyproline, an index of bone resorption, and other bone-related biochemical parameters in normal post-menopausal women.
  
  
  METHODS
  Subjects served as their own control before and after chlorothiazide treatment.
  
  
  METHODS
  Subjects were recruited by advertisement.
  
  
  METHODS
  Thirteen healthy post-menopausal women with a mean age of 65 years.
  
  
  METHODS
  Each subject was given chlorothiazide 500 mg bd po for 7 days. Fasting blood and urine samples were obtained immediately before the commencement of chlorothiazide (day 1) and 2 and 7 days after starting chlorothiazide.
  
  
  RESULTS
  Chlorothiazide decreased the urinary calcium/creatinine (mean value day 1, 0.267; day 2, 0.143; day 7, 0.135; P < 0.001) and hydroxyproline/creatinine (day 1, 0.0192; day 2, 0.0145; day 7, 0.0139; P < 0.02) molar ratios.
  
  
  CONCLUSIONS
  Chlorothiazide decreases fasting urinary hydroxyproline, a marker of bone resorption in post-menopausal women. This observation supports a potential role for thiazide diuretics in the prevention of osteoporosis. The observed fall in urinary hydroxyproline is of the same order as that seen after treatment with estrogen or calcium supplements.
authors: Department of Medicine, Royal Adelaide Hospital, Australia.
authors: C A
authors: CA
authors: Peh
authors: M
authors: M
authors: Horowitz
authors: J M
authors: JM
authors: Wishart
authors: A G
authors: AG
authors: Need
authors: H A
authors: HA
authors: Morris
authors: B E
authors: BE
authors: Nordin
mesh_terms: D000136:Acid-Base Equilibrium; D000368:Aged; D015415:Biomarkers / Q000652:urine*; D001835:Body Weight; D001862:Bone Resorption / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D002118:Calcium / Q000097:blood / Q000652:urine; D002740:Chlorothiazide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood / Q000652:urine; D005215:Fasting; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000187:drug effects / Q000652:urine*; D008593:Menopause; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood / Q000652:urine; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002740:Chlorothiazide; D012964:Sodium; D003404:Creatinine; D006909:Hydroxyproline; D011188:Potassium; D002118:Calcium