title: Elimination of cefmenoxime during continuous haemofiltration.
abstract: The elimination of cefmenoxime after single and repeated i.v. dosing was studied in 12 patients with severe renal failure and sepsis during continuous haemofiltration. More than 30% of the drug was found in the filtrate. The sieving coefficient (S) was 0.54. Vss% was unchanged 0.31 l.kg-1 in comparison with patients with normal renal function, whereas the mean t1/2ss was prolonged to about 16 h, and total clearance was reduced 20.8 ml.min-1.1.73 m-2. Once daily administration of 1 g cefmenoxime is suggested as the appropriate dose under such circumstances.
authors: Medizinische Klinik I, Stadt Köln-Merheim, Germany.
authors: J
authors: J
authors: Evers
authors: K
authors: K
authors: Borner
authors: P
authors: P
authors: Koeppe
mesh_terms: D000328:Adult; D000368:Aged; D015281:Cefmenoxime / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006440:Hemofiltration; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D015281:Cefmenoxime