Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).
Mouse genomic clones encoding the epithelin/granulin gene and its 5'- and 3'-flanking regions have been isolated and sequenced. This gene was found to be a single-copy gene, and contained 13 exons interrupted by 12 introns. Eight out of the 12 introns are classified as phase 0, and are located within the central part of each of the tandem repeats in the amino acid sequence of the epithelin/granulin precursor. The first intron is unique because of the interruption of the 5'-untranslated region and its fairly large size (approximately 2.4 kbp). Consensus sequences for several of the potential regulatory elements are present in the 5'-flanking sequence, including a common CCAAT sequence.
Baba
T
T
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Nemoto
H
H
Watanabe
K
K
Arai
Y
Y
Gerton
G L
GL
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D005091:Exons; D015698:Genomic Library; D006023:Glycoproteins / Q000235:genetics*; D000077155:Granulins; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D000077153:Progranulins; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid
D006023:Glycoproteins; D000077155:Granulins; C120204:Grn protein, mouse; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins