Arthritis in hemochromatosis.
We reviewed the clinical and radiographic features of arthropathy in 25 subjects with hemochromatosis, 16 probands and 9 discovered homozygous relatives. Clinical arthritis was present in 15/16 probands and 1/9 discovered homozygotes (p < 0.005). Radiologic evidence of arthropathy was seen additionally in 2 asymptomatic discovered homozygotes. The metacarpophalangeal joints and wrists were most commonly involved; severe hip disease occurred in 6. Patients with clinical or radiologic arthropathy were older than patients without. Arthropathy occurred in all 4 female probands, but in none of the 3 female discovered homozygotes. Chondrocalcinosis was seen in 9 subjects but was usually asymptomatic. The arthritis of hemochromatosis may be difficult to differentiate from several other joint diseases, especially calcium pyrophosphate dihydrate deposition disease.
Faraawi
R
R
University Hospital, Department of Medicine, University of Western Ontario, London, Canada.
Harth
M
M
Kertesz
A
A
Bell
D
D
D000328:Adult; D000368:Aged; D001168:Arthritis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006432:Hemochromatosis / Q000150:complications* / Q000235:genetics / Q000473:pathology; D006720:Homozygote; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011859:Radiography; D014955:Wrist Joint / Q000000981:diagnostic imaging / Q000473:pathology