title: Evidence for a role of noradrenergic neurons in the increase in concentration of preprocholecystokinin-mRNA after cerebral cortex injury in rats.
abstract: A knife cut injuring the meninges and the upper layers of rat neocortex transiently increases the levels of preprocholecystokinin-mRNA in the whole ipsilateral cortex. 48 h after the injury, the rise in gene expression was reduced by the edema-induced increase in tissue pressure which develops after the trauma. The beta-adrenoceptor antagonists alprenolol (4 mg/kg) and propranolol (1 mg/kg), given i.m. 30 min prior to the injury, reduced the increase by 75.6 and 100%, respectively. In contrast, blockade of alpha-adrenoceptors as well as of dopamine and serotonin receptors by respective antagonists did not affect the injury-induced increase in levels of preprocholecystokinin-mRNA. These results suggest that noradrenergic neurons can contribute via stimulation of beta-adrenoceptors to the initiation of the injury-induced increase in preprocholecystokinin gene expression.
authors: Department of Pharmacology, University of Freiburg, Germany.
authors: C
authors: C
authors: Olenik
authors: E
authors: E
authors: Götz
authors: A
authors: A
authors: Uhl
authors: J D
authors: JD
authors: Mondeh
authors: D K
authors: DK
authors: Meyer
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000293:injuries*; D002766:Cholecystokinin / Q000235:genetics*; D008297:Male; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011498:Protein Precursors; D012333:RNA, Messenger; C042082:preprocholecystokinin; D002766:Cholecystokinin; D009638:Norepinephrine