Bombesin acts in the brain to decrease gastric vagal efferent discharge in rats.
The central nervous system action of bombesin to influence basal gastric vagal efferent discharge (GVED) was investigated in urethane-anesthetized rats. Bombesin (62, 620, and 6200 pmol) injected intracisternally (IC) decreased GVED to 78 +/- 10%, 50 +/- 4%, and 43 +/- 3% of preinjection levels, respectively. Bombesin (620 pmol) injected IV also reduced GVED to 36 +/- 6%. Pretreatment with bombesin monoclonal antibody 2A11 completely prevented the decrease in GVED induced by bombesin (620 pmol) given IV but not IC. These data indicate that both IC and IV injections of bombesin decrease basal GVED, and that the inhibitory effect of IC injection represents a central nervous system-mediated action.
Yoshida-Yoneda
E
E
Center for Ulcer Research and Education, VA Wadsworth Medical Center, Los Angeles, CA 90073.
Wei
J Y
JY
Taché
Y
Y
D000818:Animals; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D004594:Electrophysiology; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D001839:Bombesin