Nonparametric estimation of potency ratio for dilution assays.
The paper considers the estimation of the potency of an unknown test preparation in relation to a standard in a dilution assay. The method utilizes the Mantel-Haenszel one degree of freedom chi-square approach to test consistency of the observed potency ratio with a range of alternative potency ratios. The method is nonparametric as it does not require any distributional assumptions. However, it requires the doses employed to be equally spaced logarithmically. The dose-response curve is also required to be monotone over the dose range used.
Moussa
M A
MA
Department of Community Medicine, Faculty of Medicine & Health Sciences, Al-Ain, United Arab Emirates.
D001681:Biological Assay / Q000592:standards*; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D012986:Software Validation; D013810:Therapeutic Equivalency