[Cytogenetic study of 22 adults and 3 children with acute lymphoblastic leukemia].
Between 1987 and 1990 cytogenetic studies of bone marrow and lymphocytes from peripheral blood from 25 patients with de novo ALL were performed. All cases had chromosomal aberrations; however in 23 patients a normal cell line was also present. The most important structural aberrations found were: t(17;19)(q11;p13), t(2;9;22)(q34;q34;11), t(1;7)(p13;q33), t(6;11)(q26;p16), t(3;4)(q24-25;q26), t(1;12)(q23;q34), t(2;18)(q15;p12), t(2;4)(q23;q35) and t(4;11)(q21;q23). These chromosome abnormalities correlate with the response to treatment and survival and improve the identification of high-risk patients. Our study shows the presence of some chromosomal abnormalities different to those reported in the literature; however the breakpoints involved seem to be the same which suggests that these critical regions may be directly involved in the pathogenesis of these disorders.
Arana-Trejo
R M
RM
Servicio de Genética, Hospital General de México SSa, D.F.
Cervantes-Peredo
A
A
Rozen
E
E
Kassack
J J
JJ
Gutiérrez
M
M
Kofman-Alfaro
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D014178:Translocation, Genetic
Estudio citogenético en 22 adultos y tres niños con leucemia linfoblástica aguda.