Dicyanogold (I) is a common human metabolite of different gold drugs.
Gold based drugs and their metabolites have been characterized using reversed phase, ion pairing chromatography with an inductively coupled plasma mass spectrometer as an element specific detector. For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood. The same compound is also identified in the urine and blood of a patient taking auranofin and in patients taking solganol. This represents the first identification of a specific gold metabolite in biological fluids taken from patients undergoing gold therapy and the first evidence that different gold drugs have common metabolites.
Elder
R C
RC
Department of Chemistry, University of Cincinnati, OH 45221-0172.
Zhao
Z
Z
Zhang
Y
Y
Dorsey
J G
JG
Hess
E V
EV
Tepperman
K
K
D000838:Anions; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D001310:Auranofin / Q000097:blood / Q000652:urine; D006051:Aurothioglucose / Q000097:blood / Q000652:urine; D003485:Cyanates / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006046:Gold / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006052:Gold Sodium Thiomalate / Q000097:blood / Q000652:urine; D006801:Humans
D000838:Anions; D003485:Cyanates; C043041:gold cyanide; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold