Anti-inflammatory effect of diclofenac drops after argon laser trabeculoplasty.
Using a laser flare-cell meter, the anti-inflammatory effect of diclofenac sodium drops was evaluated after argon laser trabeculoplasty in a double-masked placebo-controlled study. Fifty-three eyes with pseudoexfoliative (43 eyes) or pigmentary glaucoma (10 eyes) were randomly assigned to treatment (n = 27) or placebo (n = 26) groups. Diclofenac (0.1%) or placebo drops were administered once before and after trabeculoplasty and then four times daily for a total of 4 days. Visual acuity, intraocular pressure, and anterior chamber flare, measured with the laser flare-cell meter, were evaluated before trabeculoplasty, 3 and 6 hours after trabeculoplasty, and 1, 2, 4, 7, and 14 days after trabeculoplasty. Flare increase after argon laser trabeculoplasty was completely blocked by 0.1% topical diclofenac and the mean of maximal flare increases was reduced significantly in the diclofenac group. Therefore, 0.1% diclofenac drops represent a very efficient anti-inflammatory therapy after argon laser trabeculoplasty.
Herbort
C P
CP
Department of Ophthalmology, Hôpital Jules Gonin, University of Lausanne, Switzerland.
Mermoud
A
A
Schnyder
C
C
Pittet
N
N
D000368:Aged; D000869:Anterior Eye Segment / Q000601:surgery*; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D009877:Endophthalmitis / Q000209:etiology / Q000517:prevention & control*; D005128:Eye Diseases / Q000175:diagnosis; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D053685:Laser Therapy / Q000009:adverse effects*; D008297:Male; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D011292:Premedication; D011446:Prospective Studies; D014130:Trabeculectomy / Q000009:adverse effects*; D014792:Visual Acuity
D009883:Ophthalmic Solutions; D004008:Diclofenac