Stability of cisplatin in sodium chloride 0.9% intravenous solution related to the container's material.
The stability of cisplatin in sodium chloride 0.9% intravenous solutions contained in glass bottles, polyvinyl chloride bags, polyethylene and polypropylene containers was studied over two weeks. The solubility of cisplatin at 4 degrees C was also studied for possible precipitation. The type of container had no effect on cisplatin decomposition. No precipitation at 4 degrees C was observed within the time period studied.
Pujol Cubells
M
M
Faculty of Pharmacy, Department of Pharmacy, Barcelona, Spain.
Prat Aixela
J
J
Girona Brumos
V
V
Duran Pou
S
S
Villaronga Flaque
M
M
D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000008:administration & dosage / Q000032:analysis*; D004349:Drug Packaging; D004355:Drug Stability; D007262:Infusions, Intravenous; D007700:Kinetics; D012965:Sodium Chloride; D012996:Solutions
D012996:Solutions; D012965:Sodium Chloride; D002945:Cisplatin