Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis.
Allergic bronchopulmonary aspergillosis (ABPA) may complicate 1% to 2% of all cases of chronic asthma. Twenty-eight patients fulfilling the diagnostic criteria for ABPA but without evidence of proximal bronchiectasis [ABPA-S (seropositive)] were identified over a 12-year period and classified by stage. The majority of patients were in remission but all had chronic asthma. Serum anti-Aspergillus fumigatus (Af) IgG was lower in ABPA-S (n = 28) versus ABPA-CB (central bronchiectasis) (n = 58) at the time of initial presentation (IgG-Af index 3.62 versus 7.80, t = 3.46, P < or = .001). Serum IgG1-Af was significantly lower in ABPA-S as compared with ABPA-CB (t = 2.37, P = .011), as was serum IgG2-Af (t = 1.91, P = .031) and serum IgG4-Af (t = 1.78, P = .041). There were trends toward lower concentrations of total serum IgE, serum anti-Af-IgE, and anti-Af-IgA in ABPA-S. Eleven patients with ABPA-S were evaluated closely for a total of 63 patient-years and only four exacerbations with pulmonary infiltrates were identified. No patient in either group was observed to progress to end-stage or irreversible lung disease when early recognition and treatment were instituted. We conclude that ABPA-S represents the earliest stage or apparently a less aggressive form of ABPA.
Greenberger
P A
PA
Department of Medicine, Northwestern University Medical School, Chicago, Illinois.
Miller
T P
TP
Roberts
M
M
Smith
L L
LL
D000293:Adolescent; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D001249:Asthma / Q000188:drug therapy; D001987:Bronchiectasis / Q000150:complications*; D002675:Child, Preschool; D005540:Forced Expiratory Flow Rates; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008875:Middle Aged; D011233:Precipitin Tests; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography
D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D011241:Prednisone