Resistance to lipophilic cationic compounds in multidrug resistant leukemia cells.
Previously we have shown that multidrug resistant cells are cross-resistant to certain permanently charged cationic lipophilic compounds. In the present study we extend these observations to additional cationic lipophilic compounds with unrelated chemical structures. Study of the growth inhibitory activity of series of triphenylalkyl-phosphonium and alkyl-ammonium compounds revealed that cross-resistance to these compounds in multidrug resistant P-388 murine leukemia cells, was related to the presence of cationic charge but not to the molecular size/degree of lipophilicity.
Ramu
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Department of Oncology, Hadassah University Hospital, Jerusalem, Israel.
Ramu
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004351:Drug Resistance; D007941:Leukemia P388 / Q000473:pathology*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D012995:Solubility; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000644:Quaternary Ammonium Compounds