Concentrations of albendazole in serum, cerebrospinal fluid and hydatidous brain cyst.
A young girl with cerebral echinococcosis was treated with albendazole (13 mg/kg/d, p.o.). The concentrations of albendazole sulphoxide were determined in serum, cerebrospinal fluid and hydatidous cyst over a month. The mean ratios of concentration were: CSF/serum = 50%, cyst/serum = 40%, cyst/CSF = 80%.
Moskopp
D
D
Neurosurgical Department, University of Münster, Fed. Rep. of Germany.
Lotterer
E
E
D015766:Albendazole / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000601:surgery; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D003131:Combined Modality Therapy; D003399:Craniotomy; D004443:Echinococcosis / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D012008:Recurrence
D015766:Albendazole