title: An in vitro study of the effects of methylprednisolone on lesioned and uninjured mammalian spinal neurons.
abstract: Cultured spinal neurons were subjected to dendrite amputation 100 microns from the perikaryon and treated with methylprednisolone (MP). Survival was significantly increased by 30 micrograms/ml MP but not by 10, 20 or 60 micrograms/ml. Survival was reduced by 100 micrograms/ml MP. These results suggest: (1) MP protects neurons subjected to physical trauma, and (2) the effective dose range is very narrow. These findings may have implications for MP's observed bimodal effects in spinal cord injury.
authors: Department of Biological Sciences, University of North Texas, Denton 76203-5218.
authors: L J
authors: LJ
authors: Rosenberg-Schaffer
authors: J H
authors: JH
authors: Lucas
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D008322:Mammals; D008775:Methylprednisolone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D012016:Reference Values; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology
chemical_list: D008775:Methylprednisolone