[The effect of low doses of ionizing radiation on intracellular pH, ATP content and synthetic activity in cultured Chinese hamster fibroblasts].
X irradiation of Chinese fibroblasts with doses of 0.05-0.15 Gy was shown to cause intracellular pH (pHi) changes: its diminishing during the first 40-60 min by 0.16-0.18 pH units, then the return to the control level 120 min after irradiation and, finally, the increase by 0.18-0.20 pH units. Simultaneously, the synthesizing activity of the cells changed in the same way. The ATP level changed in the opposite way: increased when pH fell and decreased when pH grew. It was shown that pHi changes were connected with the changes in Na+/H(+)-exchange system, and they seemed to be primary in the chain of the alterations observed.
Parkhomenko
I M
IM
Perishvili
G V
GV
Turovetskiĭ
V B
VB
Kudriashov
Iu B
IuB
Rubin
A B
AB
Brovko
L Iu
LIu
D000165:Acridine Orange; D000255:Adenosine Triphosphate / Q000378:metabolism / Q000528:radiation effects*; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000378:metabolism / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects*; D006863:Hydrogen-Ion Concentration; D013997:Time Factors
D000255:Adenosine Triphosphate; D000165:Acridine Orange
Vliianie malykh doz ioniziruiushcheĭ radiatsii na vnutrikletochnyĭ pH, soderzhanie ATF i sinteticheskuiu aktivnost' kul'tiviruemykh fibroblastov kitaĭskogo khomiachka.