title: Histologic evaluation of periodontal attachment apparatus following the insertion of a biodegradable copolymer barrier in humans.
abstract: The purpose of this study was to histologically evaluate the effectiveness of polylactide:polyglycolide 50:50 (DL-PLGA) as a barrier to prevent epithelial migration and to promote new connective tissue attachment. Mucoperiosteal flaps were performed on 17 human teeth. DL-PLGA membrane was placed over the roots and alveolar bone. DL-PLGA was not placed over control teeth. Ninety days following surgery, block sections were obtained and processed for histologic evaluation. All specimens revealed a mean length of epithelial attachment within physiologic limits and recession of the gingival margin. There was little or no reattachment of the connective tissue. It is concluded that this copolymer barrier did not prevent epithelial migration nor enhance connective tissue attachment to human roots with severe horizontal bone loss and active periodontal disease.
authors: Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
authors: S
authors: S
authors: Vuddhakanok
authors: C W
authors: CW
authors: Solt
authors: J C
authors: JC
authors: Mitchell
authors: D W
authors: DW
authors: Foreman
authors: F A
authors: FA
authors: Alger
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000503:physiopathology; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D004846:Epithelial Attachment / Q000502:physiology; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010510:Periodontal Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010513:Periodontal Ligament / Q000502:physiology; D011091:Polyesters; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D007773:Lactates; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)