title: [Long-term follow-up of patients with angina pectoris-like chest pain and normal coronary angiogram].
abstract: To determine the long-term prognosis of patients (pts) with angina-like chest pain and normal coronary arteriograms, 178 pts (61 women, 117 men; mean age 48.1 years) were followed for an average of 9.8 years (5.5-13.1 years). Eight pts (4.5%) died during follow-up: One pt from acute myocardial infarction, one pt suddenly, one pt from chronic cor pulmonale and 5 pts from non-cardiac diseases. Chest pain remained constant in 137/170 surviving pts (80.6%), but disappeared in 33 pts (19.4%). Nine of the 178 pts (5.1%) developed manifest coronary artery disease (CAD): four of them (2.2%) acute myocardial infarctions including one death, after an average of 7.2 years; in five pts (2.8%) with continued chest pain a second coronary angiogram showed typical CAD. These pts with manifest CAD averaged 2.1 risk factors: six pts were smokers, two pts had elevated cholesterol levels (> 7.5 mmol/l), three pts had elevated triglyceride levels (> 2.4 mmol/l), two pts had a diabetes mellitus type IIa and six pts were hypertensives. Patients without manifestation of CAD averaged only 1.4 risk factors (p < 0.05). Our data show that pts with angina-like chest pain and normal coronary angiograms have an excellent long-term prognosis (only 0.51% of patients with new manifestations of CAD per year). However, angina-like chest pain can persist over many years.
authors: Abteilung Kardiologie, Medizinische Hochschule Hannover.
authors: K
authors: K
authors: Bargheer
authors: H J
authors: HJ
authors: Trappe
authors: P
authors: P
authors: Wenzlaff
authors: P R
authors: PR
authors: Lichtlen
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000401:mortality* / Q000503:physiopathology; D001145:Arrhythmias, Cardiac / Q000401:mortality / Q000503:physiopathology; D002423:Cause of Death; D002637:Chest Pain / Q000401:mortality* / Q000503:physiopathology; D017023:Coronary Angiography; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000209:etiology; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality* / Q000503:physiopathology; D012307:Risk Factors
vernacular_title: Langzeitverlauf von Patienten mit Angina-pectoris-ähnlichen Brustschmerzen und normalem Koronarangiogramm.