title: Molecular characteristics of uronic-acid-rich protein, a strong inhibitor of calcium oxalate crystallization in vitro.
abstract: Uronic-acid-rich protein (UAP) is a new urinary macromolecule which strongly inhibits calcium oxalate crystal formation. It is a glycoprotein with a molecular weight of about 35,000 Da, and its carbohydrate content is 8.5%. This inhibitor is composed of two polypeptidic chains crosslinked by chondroitin sulfate. It exhibits partial structural homology with alpha 1-microglobulin. The inhibitory activity seems to be supported by peptidic chains as determined by enzymatic assay.
authors: INSERM Unité 90, Hôpital Necker-Enfants Malades, Paris, France.
authors: F
authors: F
authors: Atmani
authors: B
authors: B
authors: Lacour
authors: G
authors: G
authors: Strecker
authors: P
authors: P
authors: Parvy
authors: T
authors: T
authors: Drüeke
authors: M
authors: M
authors: Daudon
mesh_terms: D000595:Amino Acid Sequence; D002129:Calcium Oxalate / Q000737:chemistry*; D003461:Crystallography; D006023:Glycoproteins / Q000737:chemistry / Q000652:urine*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013329:Structure-Activity Relationship; D014574:Uronic Acids / Q000737:chemistry
chemical_list: D006023:Glycoproteins; D014574:Uronic Acids; D002129:Calcium Oxalate