title: Excretion of bupropion in breast milk.
abstract: OBJECTIVE
  To measure the excretion of bupropion and its metabolites in breast milk. A secondary objective was to determine whether the drug accumulated in the nursing infant.
  
  
  METHODS
  Milk and plasma samples were collected from a woman taking bupropion 300 mg/d in divided doses who was breastfeeding her 14-month-old son. A single plasma sample was collected from the infant.
  
  
  RESULTS
  After a 100-mg dose, the peak bupropion breast milk concentration measured at two hours was 0.189 micrograms/mL. Milk-to-plasma ratios ranged from 2.51 to 8.58 over a six-hour interval. Two of three metabolites also were measured in milk. Bupropion and its metabolites were not detected in the single plasma sample obtained from the infant.
  
  
  CONCLUSIONS
  Bupropion accumulates in human breast milk in concentrations much higher than in maternal plasma. Two metabolites are also excreted into the milk. Neither bupropion nor its metabolites were detected in the infant's plasma, indicating that accumulation did not occur in this infant.
authors: Pharmacy Department, Women's Hospital, Long Beach Memorial Hospital Medical Center, CA 90801.
authors: G G
authors: GG
authors: Briggs
authors: J H
authors: JH
authors: Samson
authors: P J
authors: PJ
authors: Ambrose
authors: D H
authors: DH
authors: Schroeder
mesh_terms: D000328:Adult; D001942:Breast Feeding; D016642:Bupropion / Q000097:blood / Q000493:pharmacokinetics*; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008895:Milk, Human / Q000378:metabolism*
chemical_list: D016642:Bupropion