title: Cardiac geometry and mass changes associated with pacing-induced cardiomyopathy in the dog.
abstract: We evaluated the effects of chronic rapid pacing (240 beats/min) on ventricular geometry and function and on cardiac mass in a canine model. Forty dogs were studied by two-dimensional echocardiography before and after 45 days of pacing. Compared with sham-operated control animals, the paced animals had significant increases in end-diastolic and end-systolic volume and a decrease in ejection fraction. The increase in ventricular volume was primarily the result of dilation of the short axis of the ventricular lumen, without significant changes in the long-axis dimension. Paced animals had biatrial hypertrophy but no change in ventricular or total cardiac mass.
authors: Department of Internal Medicine, University of Iowa College of Medicine, Iowa City.
authors: B D
authors: BD
authors: Scott
authors: M K
authors: MK
authors: Sharma
authors: J M
authors: JM
authors: Levett
authors: C C
authors: CC
authors: Marinelli
authors: R A
authors: RA
authors: Kieso
authors: P G
authors: PG
authors: Schmid
authors: R E
authors: RE
authors: Kerber
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial / Q000379:methods; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D004285:Dogs; D004452:Echocardiography; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles