Pradimicins FS and FB, new pradimicin analogs: directed production, structures and biological activities.
Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.
Saitoh
K
K
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Suzuki
K
K
Hirano
M
M
Furumai
T
T
Oki
T
T
D000191:Actinomycetaceae / Q000737:chemistry*; D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D000095643:Pradimicins and Benanomicins
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C080895:pradimicin FB; D000095643:Pradimicins and Benanomicins; C080894:pradimicin FS