Plasma fibrinogen and its correlates in children from a biracial community: the Bogalusa Heart Study.
Fibrinogen levels were measured in 5- to 17-y-old children (n = 3047; 40% black and 49% female), from a well-defined biracial community. No significant race and sex differences in fibrinogen levels were observed, but levels increased (p < 0.001) with age or sexual maturation in black females. Adjusted for age, fibrinogen concentrations were positively correlated with ponderal index (weight/height3) (0.09-0.22, p < 0.01), triceps skinfold thickness (0.10-0.23, p < 0.05), and subscapular skinfold thickness (0.13-0.24, p < 0.01) in all race-sex groups. Weak correlations were found between fibrinogen level and blood pressure and lipoprotein components for some of the race-sex groups, but these become nonsignificant or minimal after adjustment for ponderal index and skinfolds. A positive correlation (0.12-0.16, p < 0.01) was found between fibrinogen and white blood cell count for Caucasians, which still held after adjustment for ponderal index and skinfolds. In a stepwise regression, ponderal index, white blood cell count, and HDL cholesterol showed an independent association with fibrinogen.
Bao
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W
Department of Applied Health Sciences, Tulane University Medical Center, School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112-2824.
Srinivasan
S R
SR
Berenson
G S
GS
D000293:Adolescent; D000367:Age Factors; D044383:Black People; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D008074:Lipoproteins / Q000097:blood; D008145:Louisiana; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D012737:Sex Factors; D012885:Skinfold Thickness; D044465:White People; D001741:Black or African American
D008074:Lipoproteins; D005340:Fibrinogen