title: [3 families with a congenital factor X deficiency, one of them with an associated factor XII deficiency].
abstract: Factor X deficiency constitutes one of the most uncommon congenital bleeding disorders. Here we report three families with Factor X deficiency, one of them with an associated deficit of Factor XII. Family I presented Red variant deficiency (low functional and antigenic activity, the latter in higher levels than the former). In Family II functional activity was low but antigenic one was normal (Prower defect). Besides, an heterozygous deficiency of factor XII was diagnosed. Although genetic analysis supports the hypothesis of combined deficiency, the study was possible in only two generations of the propositus, so a multiple familial deficiency could not be discarded. Finally, Family III suffered from a "classic" or Mr. Stuart deficiency (low levels in functional and immunological assays). Besides, crossed immunoelectrophoresis showed a grossly pathological pattern.
authors: Servicio de Hematología, Hospital de la Princesa, Madrid.
authors: M
authors: M
authors: Pérez Sánchez
authors: J
authors: J
authors: López
authors: J L
authors: JL
authors: López
authors: S
authors: S
authors: Haya
authors: E
authors: E
authors: Lavilla
authors: M C
authors: MC
authors: Cárdenas
authors: L
authors: L
authors: Rey
authors: N
authors: N
authors: Gómez
authors: J M
authors: JM
authors: Fernández-Rañada
mesh_terms: D000328:Adult; D005171:Factor X Deficiency / Q000150:complications / Q000151:congenital / Q000235:genetics*; D005175:Factor XII Deficiency / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
vernacular_title: Estudio de tres familias con déficit congénito de factor X, una de ellas con déficit asociado de factor XII.