Low-dose aspirin therapy to prevent preeclampsia.
OBJECTIVE
Our aim was to test the hypothesis that acetylsalicylate (aspirin) treatment reduces the incidence or severity of pregnancy-associated hypertension.


METHODS
Patients were nulliparous, healthy, and with a singleton gestation at between 20 and 22 weeks' gestation. A sample size of 600 patients was calculated on the basis of p < or = 0.05 and 90% power of observation. A 2-week placebo-controlled "run-in" was used to select compliant patients. Randomization occurred at 24 weeks, with 60 mg of aspirin or placebo treatment from randomization to delivery.


RESULTS
Follow-up was maintained on 99% of the patients. The randomized patients had a 94% pill compliance index. At randomization, serum thromboxane medians were similar in both groups. Thromboxane B2 levels in the aspirin group decreased significantly from baseline at 29 to 31 weeks, 34 to 36 weeks, and at delivery as compared with an overall increase in the placebo group. Preeclampsia developed in five of 302 women (1.7%) who received aspirin versus 17 of 302 (5.6%) who received the placebo (p = 0.009). Preeclampsia was severe in one aspirin and in six placebo recipients (p = 0.06).


CONCLUSIONS
Daily ingestion of 60 mg of aspirin beginning at 24 weeks' gestation significantly reduced the occurrence of preeclampsia.
Hauth
J C
JC
University of Alabama, Department of Obstetrics and Gynecology, Birmingham 35233-7333.
Goldenberg
R L
RL
Parker
C R
CR
Philips
J B
JB
Copper
R L
RL
DuBard
M B
MB
Cutter
G R
GR
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D004461:Eclampsia / Q000517:prevention & control; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D010298:Parity; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000517:prevention & control; D011256:Pregnancy Outcome; D011446:Prospective Studies; D013929:Thromboxane B2 / Q000097:blood
D013929:Thromboxane B2; D001241:Aspirin