title: Cellular proliferation and/or differentiation can condition modifications in the expression of AgNORs in rat anterior pituitary cells during growth.
abstract: The expression of argyrophilic nucleolar organizer regions (AgNORs) was studied in the anterior lobe of the hypophysis of 1-, 7-, 14-, 28- and 80-day-old rats. Mean area and numbers of AgNORs per nucleus decreased during this period with a simultaneous increase of both nuclear area and mean AgNOR-particle area. Comparison of our data on AgNOR expression with previously reported data on the proliferative activity and cell maturation and differentiation of anterior pituitary cells during a similar period led us to conclude that, at least in our experimental model, variations in the expression of AgNORs are more related to phenomena of cellular maturation than to proliferative activity.
authors: Department of Human Anatomy and Histology, University of Salamanca, Spain.
authors: S
authors: S
authors: Carbajo
authors: J C
authors: JC
authors: Carvajal
authors: J
authors: J
authors: Rodríguez
authors: E
authors: E
authors: Carbajo-Pérez
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D005260:Female; D006651:Histocytochemistry; D009687:Nuclear Proteins / Q000096:biosynthesis*; D009697:Nucleolus Organizer Region / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D016622:Silver Staining
chemical_list: D009687:Nuclear Proteins