title: [Folic acid supply in pregnancy--results of a prospective longitudinal study].
abstract: After discussing the problem of folic acid requirements and supply during pregnancy, the results of a longitudinal study on 162 pregnant women are presented. By measuring biochemical and morphological changes in two subgroups (non-substituted vs unspecifically substituted), the necessity of a substitution with folic acid is discussed, as there might be additional requirements for the pregnant and the foetal organism. Concentrations of folic acid in the maternal plasma and in the erythrocytes as well as the segmentation rate and hypersegmentation of the granulocytes show a clear decrease in pregnancy. At the same time there was a significant difference between the subjects substituted and not substituted; the foetus and newborn levels were much higher than their mothers' concentrations. Moreover, there was a correlation between red cells folic acid levels in the last trimester and duration and outcome of pregnancy. These results indicate a substitution with folic acid for certain populations in pregnancy, which are highlighted.
authors: Universitätsfrauenklinik Bonn.
authors: P
authors: P
authors: Bung
authors: C
authors: C
authors: Stein
authors: R
authors: R
authors: Prinz
authors: K
authors: K
authors: Pietrzik
authors: H
authors: H
authors: Schlebusch
authors: O
authors: O
authors: Bauer
authors: D
authors: D
authors: Krebs
mesh_terms: D000293:Adolescent; D000328:Adult; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood*; D005494:Folic Acid Deficiency / Q000097:blood / Q000175:diagnosis*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D009751:Nutritional Requirements; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D011446:Prospective Studies; D012016:Reference Values
chemical_list: D005492:Folic Acid
vernacular_title: Folsäureversorgung in der Schwangerschaft--Ergebnisse einer prospektiven Longitudinalstudie.