A new pericentric inv(8) in acute nonlymphocytic leukemia.
Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX/46,XX,inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.
Santoro
A
A
Dipartimento di Ematologia, Ospedale V. Cervello, USL 60, Palermo, Italy.
Carbone
P
P
Caradonna
F
F
Fabbiano
F
F
Mirto
S
S
Caronia
F
F
D007446:Chromosome Inversion; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008875:Middle Aged