The effect of chlorothiazide on bone-related biochemical variables in normal post-menopausal women.
OBJECTIVE
To evaluate the effects of short-term administration of chlorothiazide on fasting urinary hydroxyproline, an index of bone resorption, and other bone-related biochemical parameters in normal post-menopausal women.


METHODS
Subjects served as their own control before and after chlorothiazide treatment.


METHODS
Subjects were recruited by advertisement.


METHODS
Thirteen healthy post-menopausal women with a mean age of 65 years.


METHODS
Each subject was given chlorothiazide 500 mg bd po for 7 days. Fasting blood and urine samples were obtained immediately before the commencement of chlorothiazide (day 1) and 2 and 7 days after starting chlorothiazide.


RESULTS
Chlorothiazide decreased the urinary calcium/creatinine (mean value day 1, 0.267; day 2, 0.143; day 7, 0.135; P < 0.001) and hydroxyproline/creatinine (day 1, 0.0192; day 2, 0.0145; day 7, 0.0139; P < 0.02) molar ratios.


CONCLUSIONS
Chlorothiazide decreases fasting urinary hydroxyproline, a marker of bone resorption in post-menopausal women. This observation supports a potential role for thiazide diuretics in the prevention of osteoporosis. The observed fall in urinary hydroxyproline is of the same order as that seen after treatment with estrogen or calcium supplements.
Peh
C A
CA
Department of Medicine, Royal Adelaide Hospital, Australia.
Horowitz
M
M
Wishart
J M
JM
Need
A G
AG
Morris
H A
HA
Nordin
B E
BE
D000136:Acid-Base Equilibrium; D000368:Aged; D015415:Biomarkers / Q000652:urine*; D001835:Body Weight; D001862:Bone Resorption / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D002118:Calcium / Q000097:blood / Q000652:urine; D002740:Chlorothiazide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood / Q000652:urine; D005215:Fasting; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000187:drug effects / Q000652:urine*; D008593:Menopause; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood / Q000652:urine; D014527:Uric Acid / Q000097:blood
D015415:Biomarkers; D014527:Uric Acid; D002740:Chlorothiazide; D012964:Sodium; D003404:Creatinine; D006909:Hydroxyproline; D011188:Potassium; D002118:Calcium