title: Magnetic resonance and the diagnosis of short stature of hypothalamic-hypophyseal origin.
abstract: Magnetic resonance imaging was performed in 23 patients with short stature (7 had multiple pituitary hormone defect, 11 had isolated growth hormone deficiency and 5 had normal variant short stature) to investigate if there is a relation between magnetic resonance findings and results of endocrine tests. Magnetic resonance imaging of patients with multiple pituitary hormone deficiency or with serious isolated growth hormone deficiency (growth hormone < 3 micrograms/l) revealed an interrupted pituitary stalk and ectopic neurohypophysis or a mass. In patients with less serious isolated growth hormone deficiency (growth hormone > 3 micrograms/l) or with normal variant short stature, the technique revealed a normal or hypoplastic hypophysis. Magnetic resonance appears to be a useful second-level diagnostic tool in defining the type of alteration in growth defects of endocrine origin.
authors: Centro di Auxopatologia, Università di Torino, Italy.
authors: S
authors: S
authors: Vannelli
authors: T
authors: T
authors: Avataneo
authors: L
authors: L
authors: Benso
authors: F
authors: F
authors: Potenzoni
authors: S
authors: S
authors: Cirillo
authors: M
authors: M
authors: Mostert
authors: G
authors: G
authors: Bona
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000175:diagnosis* / Q000503:physiopathology; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis* / Q000503:physiopathology; D007031:Hypothalamus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010900:Pituitary Diseases / Q000175:diagnosis* / Q000503:physiopathology; D010902:Pituitary Gland / Q000473:pathology; D010907:Pituitary Hormones / Q000172:deficiency
chemical_list: D010907:Pituitary Hormones; D013006:Growth Hormone