[Apolipoprotein E phenotyping--useful in the study of hyperlipoproteinemia type III].
Apolipoprotein E (apo E) is a protein constituent of several plasma lipoproteins. Its major physiological role is to mediate the interaction of these lipoproteins and receptors. Three common apo E alleles and six phenotypes are known. The phenotype E2/E2 is associated with type III hyperlipoproteinemia. As a consequence of the increasing clinical interest in apo E phenotypes, especially in relation to the diagnosis of type III hyperlipoproteinemia, we have established a method for apo E phenotyping. Allele frequencies from a population of 211 healthy individuals are presented. The results show that, like as in Finland and Sweden the e4 allele is more frequent than in non-Nordic countries.
Hagve
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TA
Institutt for klinisk biokjemi, Rikshospitalet, Oslo.
Furuset
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Christophersen
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Ose
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L
D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D015151:Immunoblotting; D007525:Isoelectric Focusing; D008297:Male; D010641:Phenotype; D014973:Xanthomatosis / Q000097:blood / Q000235:genetics / Q000473:pathology
D001057:Apolipoproteins E
Apolipoprotein E-fenotyping--nyttig ved utredning av hyperlipoproteinemi type III.