title: Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats.
abstract: Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB binding sites, to the levels of those in a sham group, in a dose-dependent manner. Moreover, propentofylline (25 mg/kg, p.o.) significantly reduced the Bmax value of [3H]QNB binding sites compared with that in a vehicle-treated BF-lesioned group. These results suggest that successive administration of propentofylline ameliorates changes in muscarinic cholinergic receptors through improving presynaptic cholinergic dysfunction.
authors: Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
authors: K
authors: K
authors: Fuji
authors: M
authors: M
authors: Hiramatsu
authors: S
authors: S
authors: Hayashi
authors: T
authors: T
authors: Kameyama
authors: T
authors: T
authors: Nabeshima
mesh_terms: D000818:Animals; D001345:Autoradiography; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007051:Ibotenic Acid; D007700:Kinetics; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis; D010296:Parietal Lobe / Q000187:drug effects / Q000378:metabolism*; D016548:Prosencephalon / Q000502:physiology*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D014316:Tritium; D014970:Xanthines / Q000494:pharmacology*
chemical_list: D009414:Nerve Growth Factors; D011976:Receptors, Muscarinic; D014970:Xanthines; D014316:Tritium; D007051:Ibotenic Acid; C032114:propentofylline; D011813:Quinuclidinyl Benzilate