Is growth hormone associated with diabetic retinopathy?
The role of growth hormone (GH) in the pathogenesis of diabetic retinopathy was evaluated in 150 patients with non-insulin-dependent diabetes mellitus by measuring urinary GH excretion using a highly sensitive enzyme immunoassay. Urinary GH excretion was not significantly different among diabetic patients without retinopathy (mean, 2.4 ng/day; range, < 0.3-20.0 ng/day), with background retinopathy (2.7 ng/day; < 0.3-22.0 ng/day), and with proliferative retinopathy (3.1 ng/day, 0.9-15.6 ng/day). These data suggest that GH does not play a role for the pathogenesis of diabetic retinopathy through the increased physiological secretion.
Hattori
N
N
Department of Endocrinology, Kobe City General Hospital, Japan.
Moridera
K
K
Ishihara
T
T
Hino
M
M
Ikekubo
K
K
Kurahachi
H
H
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000652:urine; D003930:Diabetic Retinopathy / Q000209:etiology / Q000503:physiopathology* / Q000652:urine; D005260:Female; D013006:Growth Hormone / Q000502:physiology* / Q000652:urine; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D013006:Growth Hormone