title: The effect of insulin growth factor-1 on calvarial sutures in a Sprague-Dawley rat.
abstract: Early investigations attempting to determine the exact pathogenesis of premature closure of the cranial sutures were limited by the untoward sequelae caused by surgical procedures in animal models to simulate the development of craniosynostosis. In an attempt to create a model for evaluating the effects of manipulating the craniofacial sutures without the limitations of associated scarring, we conceived an animal prototype dependent on the effects of insulin growth factor-1 on the anterior frontal suture in a Sprague-Dawley rat model. The experimental group received 2 mg of IGF-1 over a 14-day period via a subcutaneously placed osmotic infusion pump, whereas the age-matched control group received no treatment. We present our preliminary histological results describing the effect of IGF-1 on calvarial sutures.
authors: Department of Surgery, Division of Plastic Surgery, University of California, Davis, Medical Center, Sacramento.
authors: S R
authors: SR
authors: Thaller
authors: J
authors: J
authors: Hoyt
authors: H
authors: H
authors: Tesluk
authors: R
authors: R
authors: Holmes
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D003393:Cranial Sutures / Q000187:drug effects*; D003398:Craniosynostoses / Q000601:surgery; D004195:Disease Models, Animal; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007334:Insulin-Like Growth Factor I