The unusual UVA-dependent antiviral properties of the furoisocoumarin, coriandrin.
The novel furoisocoumarin, coriandrin, which was found recently to possess an interesting combination of photobiological properties, was investigated for antiviral activity in the presence and absence of UVA (long-wavelength ultraviolet radiation). In contrast to results obtained with other antiviral furocoumarins, such as 8-MOP (8-methoxypsoralen), coriandrin was much more phototoxic to the RNA-virus Sindbis virus than to the DNA-virus murine cytomegalovirus, although both viruses were substantially more sensitive to this compound than they were to 8-MOP. Human immunodeficiency virus, HIV-1, was also susceptible to coriandrin + UVA. Another unexpected finding was that viruses without membranes were completely resistant to coriandrin. This suggests that a membrane component was a target for the compound. The antiviral activity of coriadrin was profoundly inhibited by serum components in the reaction mixtures, which suggests that the compound may have a strong affinity for certain protein or lipid materials, although maximal interference was only obtained when all components of the reaction mixture, virus, coriandrin and serum, were irradiated simultaneously. Thus it appears that coriandrin has unusual antiviral properties that would not be predicted from its chemical similarity to furocoumarins.
Hudson
J B
JB
Division of Medical Microbiology, University of British Columbia, Vancouver, Canada.
Graham
E A
EA
Harris
L
L
Ashwood-Smith
M J
MJ
D016475:3T3 Cells; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D011564:Furocoumarins / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D008730:Methoxsalen / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects* / Q000528:radiation effects
D000998:Antiviral Agents; D011564:Furocoumarins; D011838:Radiation-Sensitizing Agents; C063218:coriandrin; D008730:Methoxsalen