Treatment of idiopathic infertility with testosterone undecanoate. A double blind study.
This study refers to 50 couples treated for subfertility. Twenty five of these patients were treated with TU (Testosterone Ur econoate), the remaining 25 received placebo. Sperm characteristics, including ejaculate volume, pH, sperm density, morphology, motility, total testosterone, FSH, LH, DHT and E2 were evaluated both before and after treatment. A statistically significant increase of DHT levels was noticed after TU administration, whereas a marginally significant improvement of sperm morphology was present. Serum FSH concentrations, decreased significantly in the TU group whereas serum LH presented a slight but not statistically significant decrease; 4 pregnancies were achieved by the TU group whereas none were achieved by the patients belonging to the placebo group. The administration of TU per os to patients with idiopathic oligospermia presents a demonstrably positive effect.
Gregoriou
O
O
Second Department of Obstetrics and Gynecology, University of Athens.
Papadias
C
C
Gargaropoulos
A
A
Konidaris
S
S
Kontogeorgi
Z
Z
Kalampokas
E
E
D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
D012739:Gonadal Steroid Hormones; D013739:Testosterone; C010792:testosterone undecanoate