Ileo-caecal ulceration associated with the use of diclofenac slow release.
A 38-year-old man with seropositive arthropathy on long-standing treatment with diclofenac slow release presented with abdominal pain, diarrhoea and anaemia. Upper gastrointestinal endoscopy and barium series were unremarkable. Five months later he presented with a right iliac fossa mass. Investigations revealed discrete ulceration in the terminal ileum and caecum confirmed at laparotomy. Other possible causes of intestinal ulceration were excluded suggesting a diagnosis of non-steroidal anti-inflammatory drug associated intestinal ulceration.
Hudson
N
N
Department of Therapeutics, University Hospital, Queen's Medical Centre, Nottingham, UK.
Wilkinson
M J
MJ
Swannell
A J
AJ
Steele
R J
RJ
Hawkey
C J
CJ
D000328:Adult; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D007592:Joint Diseases / Q000188:drug therapy; D008297:Male; D014456:Ulcer / Q000139:chemically induced* / Q000175:diagnosis
D003692:Delayed-Action Preparations; D004008:Diclofenac