Complement activation by polymethyl methacrylate minimized by end-point heparin attachment.
After intraocular lens implantation, despite good clinical results, many cataract patients develop a chronic uveitis, caused by an inflammatory response to the implant. One way to improve the biocompatibility of the intraocular lens is to modify the surface by end-point heparin attachment. This study shows that complement activation caused by poly(methyl methacrylate) can be diminished by end-point heparin attachment, as demonstrated by a significant reduction in the generation of C3a and fluid phase terminal complement complexes. It suggests that assessment of complement activation is a good indicator of the biocompatibility of intraocular lenses.
Pekna
M
M
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.
Larsson
R
R
Formgren
B
B
Nilsson
U R
UR
Nilsson
B
B
D001672:Biocompatible Materials; D015153:Blotting, Western; D003167:Complement Activation; D015932:Complement C3c / Q000276:immunology; D015938:Complement Membrane Attack Complex; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006493:Heparin / Q000276:immunology*; D006801:Humans; D007910:Lenses, Intraocular; D008768:Methylmethacrylates
D001672:Biocompatible Materials; D015938:Complement Membrane Attack Complex; D008768:Methylmethacrylates; D015932:Complement C3c; D006493:Heparin