title: Production of hyperimmune bovine colostrum against Campylobacter jejuni.
abstract: Serial immunization of dairy cows with Campylobacter jejuni resulted in an enhanced serum antibody response and production of hyperimmune colostrum in all vaccinated animals. An approximate 10-fold decrease in the Camp. jejuni-specific antibody titres in colostrum was observed within 2 d post-partum. The lyophilized colostral concentrate fed to newborn calves resulted in a rapid increase in serum antibody response. Specific Camp. jejuni immunoglobulins could be detected in these animals for a further 10 weeks. The lyophilized hyperimmunized colostrum was very stable in vitro at different storage temperatures. It could be used for passive immunization to campylobacteriosis.
authors: Department of Bacteriology and Serology, National Veterinary Institute, Helsinki, Finland.
authors: J
authors: J
authors: Husu
authors: E L
authors: EL
authors: Syväoja
authors: H
authors: H
authors: Ahola-Luttila
authors: H
authors: H
authors: Kalsta
authors: S
authors: S
authors: Sivelä
authors: T U
authors: TU
authors: Kosunen
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000276:immunology; D016123:Campylobacter jejuni / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D003126:Colostrum / Q000276:immunology*; D005260:Female; D005612:Freeze Drying; D007114:Immunization
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial