title: Effects of sodium valproate on various intestinal motor functions after ileal J pouch-anal anastomosis.
abstract: BACKGROUND
  We investigate the effects of sodium valproate, a gamma-aminobutyric acid transaminase inhibitor, on the clinico-physiologic state after ileoanal anastomosis.
  
  
  METHODS
  Twelve patients (five with ulcerative colitis and seven with familial adenomatous polyposis coli) were studied in a placebo-controlled trial.
  
  
  RESULTS
  Placebo had no effect, but valproate increased the resting anal pressure by 22.4% and the maximum tolerable pouch volume by 20.7%. It also prolonged pouch emptying by 47.3%, with an associated improvement in stool frequency and incontinence. These results suggested that valproate improved both reservoir continence and sphincter continence.
  
  
  CONCLUSIONS
  Only minimal side effects were noted, so the administration of sodium valproate appears to be a safe and useful adjunct for patients with ileoanal anastomosis in the early postoperative period.
authors: Second Department of Surgery, Hyogo College of Medicine, Japan.
authors: Y
authors: Y
authors: Shoji
authors: M
authors: M
authors: Kusunoki
authors: H
authors: H
authors: Yanagi
authors: Y
authors: Y
authors: Sakanoue
authors: J
authors: J
authors: Utsunomiya
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000328:Adult; D003093:Colitis, Ulcerative / Q000601:surgery; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D007422:Intestines / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D014635:Valproic Acid / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014635:Valproic Acid; D000612:4-Aminobutyrate Transaminase