Basal and histamine-induced gastric acid secretion in alloxan diabetic rats.
1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach.
Ozçelikay
A T
AT
Department of Pharmacology, Faculty of Pharmacy, University of Ankara, Turkey.
Altan
V M
VM
Yildizoğlu-Ari
N
N
Altinkurt
O
O
Onur
F
F
Oztürk
Y
Y
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D006632:Histamine