5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activity.
The ardeemins are a new family of secondary metabolites produced by submerged fermentation of a fungus which was isolated from a soil sample collected in Brazil. Based on taxonomic studies, the producing culture was identified as Aspergillus fischeri var. brasiliensis strain AB 1826M-35. 5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent vinblastine in multidrug resistant human tumor cells.
Karwowski
J P
JP
Abbott Laboratories, Abbott Park, Illinois 60064.
Jackson
M
M
Rasmussen
R R
RR
Humphrey
P E
PE
Poddig
J B
JB
Kohl
W L
WL
Scherr
M H
MH
Kadam
S
S
McAlpine
J B
JB
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D005285:Fermentation; D006571:Heterocyclic Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D011744:Pyrimidinones / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014747:Vinblastine / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D006571:Heterocyclic Compounds; D011744:Pyrimidinones; C080891:5-N-acetylardeemin; D014747:Vinblastine