[The use of the organs of slaughtered animals for the testing of drugs: suitability of the bovine udder for the study of substances active through the skin].
Various in vitro models are used to study the transdermal penetration and absorption of test compounds. The isolated perfused bovine udder is described as a new in vitro model. Using bovine udders from slaughtered healthy cows, the percutaneous absorption of dexamethasone, benzoyl peroxide and isosorbide dinitrate was measured. For further validation of the described model, additional studies are necessary.
Kietzmann
M
M
Institut für Pharmakologie, Toxikologie, Tierärztlichen Hochschule, Hannover.
Löscher
W
W
D000826:Animal Testing Alternatives; D000818:Animals; D001585:Benzoyl Peroxide / Q000493:pharmacokinetics; D002417:Cattle; D003907:Dexamethasone / Q000493:pharmacokinetics; D005260:Female; D007548:Isosorbide Dinitrate / Q000493:pharmacokinetics; D008321:Mammary Glands, Animal / Q000378:metabolism*; D009924:Organ Culture Techniques; D012869:Skin Absorption
D003907:Dexamethasone; D007548:Isosorbide Dinitrate; D001585:Benzoyl Peroxide
Die Verwendung von Schlachttierorganen zur Prüfung von Arzneimitteln: Eignung des Rindereuters zur Untersuchung von hautwirksamen Stoffen.