Evaluation of [11C]thymidine for measurement of cell proliferation in fast dividing tissues.
The purpose of this study was to investigate the possibility of using [11C]thymidine as a tumor marker for positron emission tomography studies. Biodistribution studies were set up to investigate the in vivo behavior of [11C]thymidine. Simultaneously, the DNA incorporation in fast dividing tissues and catabolism was studied. Our results confirm that [11C]thymidine can be used for detection of cell proliferation by positron emission tomography. As such, it can produce supplementary information in cancer research.
Poupeye
E M
EM
Laboratoria voor Medische Biochemie en voor Klinische Analyse, Rijksuniversiteit Gent, Belgium.
Goethals
P P
PP
Dams
R F
RF
De Leenheer
A P
AP
van Eijkeren
M E
ME
D000818:Animals; D002250:Carbon Radioisotopes; D002455:Cell Division / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013936:Thymidine / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D004247:DNA; D013936:Thymidine