title: B-type large-cell primary splenic lymphoma with massive involvement of the red pulp.
abstract: A B-type large-cell primary splenic lymphoma with massive red-pulp involvement was diagnosed in a 64-year-old woman presenting with malaise, fever, anemia, atypical lymphoid cells in peripheral blood, and splenomegaly. This case differs from most splenic lymphomas both macroscopically and microscopically. At macroscopic examination, the spleen was homogeneously red without tumoral nodules or masses. Microscopically, the cords of the red pulp were extensively invaded by tumor cells maintaining patient sinuses. The white pulp was reduced by expansion of the red pulp. To our knowledge only few additional cases of splenic lymphoma with similar features have been previously described. The differential diagnosis of this unusual form of lymphoma with other lymphoproliferative disorders is briefly discussed.
authors: Biological Hematology Department, Postgraduate School of Hematology, Farreras Valenti, Hospital Clinic, Barcelona, Spain.
authors: C
authors: C
authors: Salgado
authors: E
authors: E
authors: Feliu
authors: E
authors: E
authors: Montserrat
authors: N
authors: N
authors: Villamor
authors: J
authors: J
authors: Ordi
authors: J L
authors: JL
authors: Aguilar
authors: J L
authors: JL
authors: Vives-Corrons
authors: C
authors: C
authors: Rozman
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D013154:Spleen / Q000473:pathology; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013163:Splenomegaly; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone