title: Evaluation of parametric and nonparametric two one-sided tests procedures for assessing bioequivalence of average bioavailability.
abstract: A simulation study was conducted to compare the levels of significance and power between Schuirmann's and nonparametric two one-sided tests procedures for a 2 x 2 crossover design under different combinations of sample sizes, intrasubject variabilities, and underlying distributions. Empirical results suggest that Schuirmann's two one-sided tests procedure is robust to minor departure from the assumption of normality.
authors: Berlex Laboratories, Inc., Wayne, New Jersey 07470.
authors: J P
authors: JP
authors: Liu
authors: C S
authors: CS
authors: Weng
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000706:statistics & numerical data*; D010599:Pharmacokinetics; D013810:Therapeutic Equivalency