A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region.
The human major histocompatibility complex (MHC) region is a genomic region spanning about 4000 kilobases (kb) including the class I, class II, and class III subregions. The class I subregion is larger than the two others but with fewer genes described to date. It includes a) classical human leucocyte antigen (HLA) class I genes (HLA-A, HLA-B, HLA-C) which are highly polymorphic and encode products presenting the endogenous antigenic peptides to the T-cell receptors, and b) non-classical class I genes (HLA-E, HLA-F, HLA-G) whose function is still unknown. In this study, we describe the first coding sequence which is not structurally related to the class I genes, although it is localized within the MHC class I region. This novel gene, P5-1, belongs to a multiple copy family, all members of which map within the MHC. Although the P5-1 sequence showed no similarity to sequences in different databanks, its transcription, which is restricted to lymphoid tissues, argues for an immunological function of its product.
Vernet
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C
CNRS CRPG-UPR 8291, CHR Purpan, Toulouse, France.
Ribouchon
M T
MT
Chimini
G
G
Jouanolle
A M
AM
Sidibé
I
I
Pontarotti
P
P
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D005796:Genes; D006801:Humans; D008285:Major Histocompatibility Complex; D008969:Molecular Sequence Data; D005810:Multigene Family; D011506:Proteins / Q000235:genetics*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D015183:Restriction Mapping
C080521:HCP5 long noncoding RNA, human; D011506:Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated