Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene.
We have isolated and characterized genomic clones of the 5' region of the human PDGF A-chain gene. The putative "TATAA" box was identified 876 bp upstream of the translation initiation site. A significant number of potential regulatory elements were identified in DNA sequences upstream of the "TATAA" box and were also found within the introns sequenced. The DNA sequence results differ significantly from those reported for the PDGF B-chain gene, suggesting a basis for the expression of the PDGF A-chain gene and the B-chain gene under very different conditions.
Takimoto
Y
Y
Department of Medicine, Jewish Hospital, Washington University Medical Center, St. Louis, MO 63110.
Li
W Y
WY
Wang
Z Y
ZY
Tong
B D
BD
Deuel
T F
TF
D000595:Amino Acid Sequence; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D010982:Platelet-Derived Growth Factor / Q000737:chemistry* / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics; D020574:Proto-Oncogene Proteins c-sis; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D016385:TATA Box
D010982:Platelet-Derived Growth Factor; D011518:Proto-Oncogene Proteins; D020574:Proto-Oncogene Proteins c-sis; C075278:platelet-derived growth factor A