title: Anterior corneal disease of epidermolysis bullosa simplex.
abstract: We report the histopathological findings of the anterior cornea from a patient with skin biopsy-proven epidermolysis bullosa simplex. As seen with light microscopy, the cornea had a fibrocellular pannus deep to a thickened epithelial basement membrane. Transmission electron microscopy of the anterior cornea demonstrated a nonhomogeneous basal epithelial layer with abnormal attachment complexes to an irregular, multilaminar basement membrane. The findings of transmission electron microscopy of the bulbar conjunctiva were normal.
authors: Cornea Service, Massachusetts Eye and Ear Infirmary, Boston 02114.
authors: A P
authors: AP
authors: Adamis
authors: O D
authors: OD
authors: Schein
authors: K R
authors: KR
authors: Kenyon
mesh_terms: D000328:Adult; D001485:Basement Membrane / Q000648:ultrastructure; D003315:Cornea / Q000648:ultrastructure*; D003316:Corneal Diseases / Q000473:pathology*; D016110:Epidermolysis Bullosa Simplex / Q000473:pathology*; D004848:Epithelium / Q000648:ultrastructure; D006801:Humans; D008297:Male