[Coronary vasodilation during intracoronary injection of papaverine and acetylcholine in syndrome X: evaluation by coronary arteriograms and coronary venous oxygen saturation dynamics].
To evaluate coronary vasodilatory reserve in syndrome X, left coronary arteriography and continuous measurement of coronary venous oxygen saturation (CSO2-Sat) were performed during intracoronary injection of papaverine (PAP) and acetylcholine (ACh) in 11 patients of syndrome X and 13 control subjects. Coronary diameter after PAP increased 10.2% in the control group and 9.8% in the syndrome X group, but after ACh decreased 1.7% in the control group and decreased 2.3% in the syndrome X group. These changes in coronary diameter by PAP and ACh in the two groups were not significantly different. However, coronary vasodilatory responses estimated by CSO2-Sat dynamics to ACh and to ACh/PAP were significantly lower in the syndrome X group than those in the control group (p < 0.05), although coronary response to PAP in the 2 groups was not significantly different. These findings suggest that endothelial-dependent vasodilation of coronary microcirculation is decreased in syndrome X.
Fujino
Y
Y
Second Department of Internal Medicine, Hirosaki University School of Medicine.
Mikuniya
A
A
Narita
T
T
Takahashi
M
M
Satoh
M
M
Mori
Y
Y
Wada
K
K
Miura
T
T
Hanadate
Y
Y
Onodera
K
K
D000109:Acetylcholine / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010208:Papaverine / Q000494:pharmacology*; D013577:Syndrome; D014664:Vasodilation / Q000187:drug effects*
D010208:Papaverine; D000109:Acetylcholine; D010100:Oxygen