title: Response to intermittent RU486 in women.
abstract: OBJECTIVE
  To determine the effects of intermittent administration of the antiprogestin RU486 on ovarian function.
  
  
  METHODS
  Three different regimens of RU486 were tested.
  
  
  METHODS
  Nine healthy regularly menstruating volunteers protected by an intrauterine device or surgical sterilization.
  
  
  METHODS
  Two groups of three women each received 10 mg or 50 mg RU486 at weekly intervals for 5 weeks. Another three women received 50 mg RU486 for 3 consecutive days at 10-day intervals for 80 days.
  
  
  METHODS
  Serum E2, P and RU486 levels. Ovarian ultrasound (US) and serum LH and FSH in select subjects.
  
  
  RESULTS
  The predominant effect was partial inhibition of E2 secretion and suppressed P levels. During a total aggregate of 16 treatment months, there were seven episodes of elevated P levels; however, US did not always indicate the occurrence of normal ovulation.
  
  
  CONCLUSIONS
  Intermittent RU486 administration can interfere with normal follicular development and function, but its clinical application may require a more effective dose and/or timing of administration.
authors: Center for Biomedical Research, Population Council, New York, New York 10021.
authors: I M
authors: IM
authors: Spitz
authors: H B
authors: HB
authors: Croxatto
authors: A M
authors: AM
authors: Salvatierra
authors: O
authors: O
authors: Heikinheimo
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D015735:Mifepristone / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D010053:Ovary / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D015735:Mifepristone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone