title: Nerve growth factor revisited.
abstract: Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase, as a receptor and (3) it shares homology with at least three other factors, now collectively called neurotrophins, which have a spectrum of target cells.
authors: Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717.
authors: R A
authors: RA
authors: Bradshaw
authors: T L
authors: TL
authors: Blundell
authors: R
authors: R
authors: Lapatto
authors: N Q
authors: NQ
authors: McDonald
authors: J
authors: J
authors: Murray-Rust
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation; D000090063:Proto-Oncogene Mas; D017475:Receptors, Nerve Growth Factor / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: C000715470:MAS1 protein, human; D009414:Nerve Growth Factors; D000090063:Proto-Oncogene Mas; D017475:Receptors, Nerve Growth Factor