title: Double-blind placebo controlled randomized trial of indomethacin on urodynamic values measured by radionuclide imaging.
abstract: The effect of the prostaglandin synthetase inhibitor, indomethacin on urodynamic values measured by radionuclide imaging was studied in 17 men in a double-blind placebo controlled randomized trial. Measurements were made of voiding time, time for 50% emptying, average flow rate, ejection fraction, post-void residual urine volume, voided volume, and total bladder volume. Statistical analyses indicated no placebo-indomethacin differences between the two groups. Although prostaglandins are thought to contribute to the act of micturition by maintenance of bladder tone and contractility, our studies indicate that a standard dose of the prostaglandin inhibitor, indomethacin, did not affect the voiding component of bladder function. Patients need not discontinue prostaglandin inhibitors and other non-steroidal anti-inflammatory drugs with such effects prior to urodynamic testing.
authors: Nuclear Medicine Service, VA Medical Center, Hampton, Virginia.
authors: T K
authors: TK
authors: Chaudhuri
authors: S
authors: S
authors: Fink
authors: I C
authors: IC
authors: Netto
authors: S K
authors: SK
authors: Wilson
authors: P
authors: P
authors: Kolm
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D001743:Urinary Bladder / Q000000981:diagnostic imaging; D014554:Urination / Q000187:drug effects; D014563:Urodynamics / Q000187:drug effects*
chemical_list: D007213:Indomethacin