title: LA-1 oncogene. A possible new prognostic index for evaluating cervical squamous intraepithelial lesions.
abstract: Cervical biopsies from 96 patients referred to the Union Memorial Hospital Colposcopy Clinic were analyzed for the expression of the LA-1 oncogene by using an antibody directed against a 13 amino acid epitope of the oncogene product. The expression of the oncogene was found to correlate with the grade of the cervical intraepithelial lesion. A trend was suggested even though chi 2 analysis was not significant (P = .08). Further studies are warranted to determine whether the LA-1 test predicts persistence or progression of the disease.
authors: Department of Gynecology and Obstetrics, Union Memorial Hospital, Baltimore, Maryland.
authors: R
authors: R
authors: Sainz de la Cuesta
authors: T P
authors: TP
authors: Reed
authors: J C
authors: JC
authors: Brothman
authors: N H
authors: NH
authors: Dubin
mesh_terms: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000276:immunology; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000276:immunology; D015153:Blotting, Western; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D004564:Electrocoagulation; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015513:Oncogene Proteins / Q000096:biosynthesis* / Q000276:immunology; D011379:Prognosis; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C081121:LA-1 oncogene protein, human; D015513:Oncogene Proteins