Agglutinins from aquatic insects--tumor cell agglutination activity.
Agglutinins were identified in whole body extracts of aquatic insects by means of murine tumor cell agglutination, using sarcoma 180 ascites, Ehrlich, and MM-46 cells. Screening revealed agglutinins in 5 of 10 of the larvae tested, and in 2 of 6 of the water-dwelling adult insects; Gerris paludum insularis and Gyrinus japonicus. Only the agglutinin from adult G. paludum also agglutinated human erythrocytes. An ascites tumor was converted into a solid form in vivo after administration of G. paludum agglutinin. The observation that these aquatic insect agglutinins preferentially agglutinate tumor cells has considerable implications in terms of anti-tumor effects such as inhibition of cell proliferation and metastasis.
Kawauchi
H
H
Cancer Research Institute, Tohoku College of Pharmaceutical Sciences, Sendai, Japan.
Hosono
M
M
Takayanagi
Y
Y
Nitta
K
K
D000371:Agglutination; D000373:Agglutinins / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006384:Hemagglutination; D006801:Humans; D007313:Insecta / Q000737:chemistry*; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D012510:Sarcoma 180 / Q000276:immunology / Q000473:pathology / Q000628:therapy
D000373:Agglutinins