Regulation of serotonin-induced calcium uptake in Spisula oocytes by tricyclic antidepressants.
The effect of tricyclic antidepressants on 5-hydroxytryptamine (serotonin or 5-HT)-induced maturation and Ca2+ uptake in Spisula oocytes was determined. The drugs at a concentration of 20 microM completely blocked germinal vesicle breakdown and 45Ca2+ uptake by Spisula oocytes. The order of effectiveness of the antidepressants were imipramine > desipramine > clomipramine. The present findings suggest that the action of tricyclic antidepressants is to regulate Ca2+ uptake into 5-HT-responsive cells.
Juneja
R
R
Center for Biomedical Research, Population Council, New York, NY 10021.
Ueno
H
H
Segal
S J
SJ
Koide
S S
SS
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D049872:Bivalvia / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D009865:Oocytes / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology*
D000929:Antidepressive Agents, Tricyclic; D002132:Calcium Radioisotopes; D012701:Serotonin; D002118:Calcium