[The role of estradiol and progesterone receptors in the selection of endocrine therapy fo patients with fibrocystic mastopathy].
Estradiol and progesterone receptors were analyzed in breast tissue of 100 women with mastopathy fibrocystic. Four groups were found according to the receptors detected: (R-E+, R-Pg+); (R-E+, R-Pg-); (R-E-; R-Pg+); (R-E-, R-Pg-). Ten percent were positive for both receptors, while 75 percent were negative for both estradiol and progesterone receptors. Ten percent were estradiol receptor positive (R-E+). Eight percent were progesterone receptor positive (R-Pg+). In this pathology type were considered "receptor positive" when specific binding was higher than 6 fmol/mg. protein. These "receptor positive" had specific binding in the range of 6.1-80 fmol/mg. protein and was considered "receptor negative" when specific binding was less than 6 fmol/mg. protein. While there was no correlation between the two receptors and patient age. We discuss the presence, type of estradiol and progesterone receptors for the hormonal treatment of patients with mastopathy fibrocystic.
Lucía Salazar
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Unidad de Investigación Clínica, Hospital de Gineco-Obstetricia No. 4 Luis Castelazo Ayala, IMSS, México, D.F.
Calzada
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L
D000328:Adult; D000367:Age Factors; D000075202:Contraindications; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005348:Fibrocystic Breast Disease / Q000737:chemistry / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D011485:Protein Binding; D011959:Receptors, Estradiol / Q000032:analysis / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000032:analysis / Q000378:metabolism*
D004967:Estrogens; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone
Receptores a estradiol y progesterona para la elección de la terapia endócrina en pacientes con mastopatía fibroquística.