title: Portal vein thrombosis after elective splenectomy. An underappreciated, potentially lethal syndrome.
abstract: We describe seven cases of thrombosis of the portal and splenic vein after elective splenectomy. The diagnosis was initially unrecognized in all patients and was confused with biliary sepsis (three cases), postoperative pancreatitis (three cases), or pulmonary emboli (one case). Two patients in whom the diagnosis of portal vein thrombosis was not made within 3 days of disease onset died. In the five survivors, the diagnosis was based on clinical suspicion, confirmed with color flow Doppler ultrasonography or computed tomography with intravenous contrast material, and treated with thrombolytic agents, anticoagulants, and antibiotics. In two patients, splenic vein thrombus was visualized on initial postoperative imaging studies and the thrombus subsequently extended into the portal vein. Portal vein thrombosis should be considered in patients with fever and abdominal complaints after splenectomy. Urgent treatment with thrombolysis and anticoagulants may preserve bowel integrity and be lifesaving.
authors: Department of Surgery, Massachusetts General Hospital, Boston 02114.
authors: D W
authors: DW
authors: Rattner
authors: L
authors: L
authors: Ellman
authors: A L
authors: AL
authors: Warshaw
mesh_terms: D000368:Aged; D000740:Anemia / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008642:Mesenteric Veins / Q000000981:diagnostic imaging; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis; D010198:Pancytopenia / Q000601:surgery; D011169:Portal Vein / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D013156:Splenectomy / Q000009:adverse effects*; D013162:Splenic Vein / Q000000981:diagnostic imaging; D013300:Streptokinase / Q000627:therapeutic use; D015996:Survival Rate; D013577:Syndrome; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D013300:Streptokinase