[Factor XII (Hageman factor) deficiency: a risk factor for development of thromboembolism. Incidence of factor XII deficiency in patients after recurrent venous or arterial thromboembolism and myocardial infarction].
103 patients suffering from recurrent venous thrombosis, recurrent arterial thromboembolism and/or recurrent myocardial infarction and 50 healthy subjects were tested for Hageman factor (F XII) coagulant activity and antigen. Among the 103 patients we identified 15 subjects with F XII deficiency (15%), 3 with protein C deficiency (3%) and 3 with protein S deficiency (3%). Combined F XII and protein C, protein S or antithrombin III deficiency was not observed. The 103 patients were divided into subgroups according to the type of thrombotic complication. Among patients with exclusively recurrent venous thromboembolism 8% (p = 0.153) were deficient in F XII. Among patients suffering from recurrent arterial thromboembolism and/or myocardial infarction, the incidence of F XII deficiency was significantly higher (20%, p < 0.003). In 67% of the patients with F XII deficiency a positive family history of thrombosis could be established. In contrast, only 32% (p = 0.043) of all venous and 28% (p = 0.019) of all arterial thrombosis patients had a positive family history. We believe that reduced levels of F XII should be considered as a risk factor in the development of thromboembolism. Consequently, more attention should be payed to the measurement of F XII when evaluating thromboembolic risk factors especially in cases of recurrent arterial thromboembolism and/or myocardial infarction.
Halbmayer
W M
WM
Zentrallaboratorium, Krankenhauses, Stadt Wien-Lainz.
Mannhalter
C
C
Feichtinger
C
C
Rubi
K
K
Fischer
M
M
D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests; D005174:Factor XII / Q000032:analysis; D005175:Factor XII Deficiency / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics; D010375:Pedigree; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood* / Q000235:genetics; D013924:Thrombophlebitis / Q000097:blood* / Q000235:genetics
D005174:Factor XII
Faktor-XII- (Hageman-Faktor-) Mangel: ein Risikofaktor für die Entstehung von Thromboembolien. Inzidenz des Faktor-XII-Mangels bei Patienten nach rezidivierenden venösen oder arteriellen Thromboembolien und Myokardinfarkten.