[The use of picotamide in nephropathy with mesangial IgA deposits. The effect on thromboxane generation].
IgA nephropathy (Berger's disease) is one of the commonest forms of glomerular disease, not rarely progressing to renal failure. Hemostatic system activation may play a role in the development of glomerular injury. In a series of 12 adult patients affected with IgA nephropathy we have observed increased plasma levels of D-dimer, a stable end-product of cross-linked fibrin degradation that is considered a reliable index of blood clotting activation, as well as "in vitro" raised generation of thromboxane, the main platelet product of arachidonic acid metabolism that seems to play an important role in glomerulosclerosis. Picotamide, a novel antiplatelet drug acting as thromboxane synthase inhibitor as well as thromboxane receptor antagonist, administered for 8-12 weeks, was effective in reducing thromboxane generation. We conclude that picotamide may be useful in the management of glomerular nephropathy.
Sagripanti
A
A
Istituto di Clinica Medica I, Università degli Studi di Pisa.
Cupisti
A
A
Giannessi
D
D
Baicchi
U
U
Bernini
W
W
de Caterina
R
R
Barsotti
G
G
D000293:Adolescent; D000328:Adult; D004341:Drug Evaluation; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000187:drug effects; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010795:Phthalic Acids / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000096:biosynthesis* / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis / Q000187:drug effects
D005338:Fibrin Fibrinogen Degradation Products; D010795:Phthalic Acids; D010975:Platelet Aggregation Inhibitors; C036309:fibrin fragment D; D014841:von Willebrand Factor; D013929:Thromboxane B2; C011581:picotamide
L'impiego della picotamide nella nefropatia a depositi mesangiali di IgA. Effetto sulla generazione del trombossano.