The long-term observation of the transplantation of encapsulated rat islets to the diabetic mice.
Rat islets encapsulated in the immuno-isolated membrane were transplanted intraperitoneally into 11 streptozotocin induced diabetic mice. The effective rate was 91% while all rejected in the 11 nonencapsulated xenograft group. 4 mice showed complete remission and longest normoglycemic period in those mice was 360 days. The pathological changes of islets of the long-term successful xenograft group were studied and showed atrophy. It proved that the immuno-isolated membrane can protect rejection during xeno-transplantation.
Shu
C
C
Artificial Cells Research Lab, First Affiliated Hospital, Chongqing University of Medical Sciences, Sichuan, China.
He
J
J
D000464:Alginates; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D004339:Drug Compounding; D005260:Female; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D016381:Islets of Langerhans Transplantation; D051379:Mice; D011107:Polylysine; D051381:Rats; D017207:Rats, Sprague-Dawley
D000464:Alginates; D006603:Hexuronic Acids; D011107:Polylysine; D020723:Glucuronic Acid