Fate of beta-cyclodextrin in the human intestine.
We assessed the fate of beta-cyclodextrin, which is composed of seven alpha(1-->4)-linked glucose units in ring structure, in the human gastrointestinal tract. In four healthy ileostomists, ileal effluent was collected after oral administration of beta-cyclodextrin during fasting (10 g of beta-cyclodextrin) and postprandially (10 g of beta-cyclodextrin three times daily with meals). In 10 healthy volunteers, the amount of beta-cyclodextrin passing into the colon was determined by means of the breath hydrogen technique using lactulose as a standard, and stools were collected after oral administration of beta-cyclodextrin during fasting (10 g of beta-cyclodextrin) and postprandially (10 g of beta-cyclodextrin three times daily with meals). In ileostomists, we recovered from the small intestine 91 +/- 5% and 97 +/- 10% (mean +/- SD) of beta-cyclodextrin ingested during fasting and with meals, respectively. In healthy volunteers, H2 excretion in breath after beta-cyclodextrin ingestion was low compared with excretion after lactulose, but only traces of beta-cyclodextrin were recovered in stools. We conclude that beta-cyclodextrin is poorly hydrolyzed in the human small intestine but that it is fermented by the colonic flora with apparent minimal H2 production.
Flourié
B
B
INSERM U290, Hôpital Saint-Lazare, Paris, France.
Molis
C
C
Achour
L
L
Dupas
H
H
Hatat
C
C
Rambaud
J C
JC
D000284:Administration, Oral; D000328:Adult; D001944:Breath Tests; D003106:Colon / Q000378:metabolism*; D003505:Cyclodextrins / Q000008:administration & dosage / Q000378:metabolism*; D005215:Fasting; D005243:Feces / Q000737:chemistry; D005260:Female; D005502:Food; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007081:Ileostomy; D007082:Ileum / Q000378:metabolism*; D007792:Lactulose / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D007792:Lactulose; D006859:Hydrogen; C031215:betadex