Distribution of serine esterase activity in the lymphoid system of C57BL/6 mice, effect of aging on the enzymatic activity.
1. The activity of serine esterase (SE) was investigated in the lymphoid system of C57BL/6 mice. SE activity increased in the lymphoid tissues with their content of mature T-lymphocytes, except that high levels were also observed in various populations of bone marrow cells. 2. The maturation of T-lymphocytes in the thymus was accompanied by an increase in their SE activity. 3. Experiments on the influence of age on SE activity showed that while thymocytes were not affected, a three-fold increase in activity occurs in spleen lymphocytes between the ages of 26 and 78 wk.
Barja
P
P
Departamento de Bioquimica y Biologia Molecular, Facultad de Biologia, Universidad de Santiago de Compostela, Spain.
Freire
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology; D001853:Bone Marrow / Q000201:enzymology; D004950:Esterases / Q000378:metabolism*; D008214:Lymphocytes / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000201:enzymology; D013950:Thymus Gland / Q000166:cytology
D004950:Esterases; C022635:serine esterase