Lipid-bound sialic acid, prostaglandin E and histamine in head and neck cancer.
Blood concentration of lipid-bound sialic acid (LBSA), prostaglandin E (PGE) and histamine were determined in 37 patients with carcinoma of hypopharynx and larynx (supraglottic and glottic), in 12 non-cancer patients and in 10 healthy subjects. The concentration of LBSA was significantly increased in 94.4% cancer patients preoperatively and fell to somewhat lower levels within 1 month after tumour resection. In patients with complete tumour resection and no tumour recurrences within 2 years, it steadily decreased thereafter, reaching normal levels within 6-24 months after surgery, whereas in patients with tumour recurrences or incomplete tumour resection it rose again within 6 months after tumour resection. Similarly, the concentration of PGE was significantly increased in about two thirds of cancer patients (67.6%) preoperatively, dropped significantly within 1 month after tumour resection and rose again in patients with tumour recurrences. Preoperative histamine concentration was decreased in 24.3% of cancer patients and postoperatively it rose both in patients with or without tumour recurrences.
Klapan
I
I
ENT Department, School of Medicine, University of Zagreb, Croatia.
Katić
V
V
Culo
F
F
Sabolović
D
D
Cuk
V
V
Fumić
K
K
Simović
S
S
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000097:blood* / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000601:surgery; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D009364:Neoplasm Recurrence, Local / Q000097:blood; D011458:Prostaglandins E / Q000097:blood*; D012794:Sialic Acids / Q000097:blood*; D013997:Time Factors
D014408:Biomarkers, Tumor; D008055:Lipids; D011458:Prostaglandins E; D012794:Sialic Acids; C054080:lipid-associated sialic acid; D006632:Histamine; D019158:N-Acetylneuraminic Acid