Seizure exacerbation related to beta-lactam antibiotics in a child with cerebral dysgenesis.
A three-year-old boy with right hemimegalencephaly, developmental delay and left hemiparesis had well-controlled left focal seizures. Occasionally he had generalized seizures if he was given beta-lactam antibiotics. An EEG with simultaneous penicillin injection was performed to examine this apparent association: a secondarily generalized seizure was documented within two minutes of intravenous administration of the penicillin. This procedure confirmed the suspicion of a causal link between antibiotic treatment and seizures. The factors increasing susceptibility to beta-lactam antibiotic-induced seizures are reviewed.
Keskin
S
S
Cerrapasa University, Istanbul, Turkey.
Konkol
R J
RJ
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000503:physiopathology* / Q000601:surgery; D002675:Child, Preschool; D004569:Electroencephalography; D007839:Functional Laterality; D006801:Humans; D008297:Male; D011859:Radiography; D012640:Seizures / Q000139:chemically induced*; D017287:Ventriculoperitoneal Shunt; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams