LA-1 oncogene. A possible new prognostic index for evaluating cervical squamous intraepithelial lesions.
Cervical biopsies from 96 patients referred to the Union Memorial Hospital Colposcopy Clinic were analyzed for the expression of the LA-1 oncogene by using an antibody directed against a 13 amino acid epitope of the oncogene product. The expression of the oncogene was found to correlate with the grade of the cervical intraepithelial lesion. A trend was suggested even though chi 2 analysis was not significant (P = .08). Further studies are warranted to determine whether the LA-1 test predicts persistence or progression of the disease.
Sainz de la Cuesta
R
R
Department of Gynecology and Obstetrics, Union Memorial Hospital, Baltimore, Maryland.
Reed
T P
TP
Brothman
J C
JC
Dubin
N H
NH
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000276:immunology; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000276:immunology; D015153:Blotting, Western; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D004564:Electrocoagulation; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015513:Oncogene Proteins / Q000096:biosynthesis* / Q000276:immunology; D011379:Prognosis; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C081121:LA-1 oncogene protein, human; D015513:Oncogene Proteins