title: [Hypercalcemia as an emergency].
abstract: The hypercalcemic syndrome and the relation of serum calcium with the concentration of ionic calcium and albumin are shortly described. The pathogenetic significance of local, cytokine-induced bone destruction and of the osteoclast-stimulating effect by "parathyroid hormone related peptide" leading to "humoral hypercalcemia of malignancy" is underscored. In a hypercalcemic emergency the therapeutic strategy should combine adequate rehydration and induction of calciuresis by furosemide and the intravenous application of a rapid-onset, calcium lowering substance such as calcitonin and, simultaneously, of a slow-onset, long-acting bisphosphonate such as pamidromate, which may be infused as a single dose.
authors: Medizinische Universitätsklinik, Inselspital Bern.
authors: A
authors: A
authors: Rosenmund
mesh_terms: D002116:Calcitonin / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use; D004630:Emergencies; D005440:Fluid Therapy; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000628:therapy*; D006961:Hyperparathyroidism / Q000150:complications; D009369:Neoplasms / Q000150:complications; D000077268:Pamidronate
chemical_list: D004164:Diphosphonates; D005665:Furosemide; D002116:Calcitonin; D000077268:Pamidronate; D002118:Calcium
vernacular_title: Hyperkalzämie als Notfall.