Propofol infusion and the incidence of emesis in pediatric outpatient strabismus surgery.
A prospective, randomized, double-blind study was conducted to examine the effect of a propofol infusion on the incidence of postoperative emesis in children undergoing outpatient strabismus surgery. Seventy-eight children, aged 3-12 yr, were allocated randomly to receive either nitrous oxide and halothane or nitrous oxide and a propofol infusion for the maintenance of anesthesia. The overall incidence of vomiting during the first 24 h was 64% in those receiving halothane and 41% in those receiving the propofol infusion; this difference was statistically significant (P < 0.05). In children who received no opioids postoperatively, the incidence of vomiting in the first 24 h was 71% in the halothane group and 24% in the propofol group; this difference was also significant (P = 0.001). We conclude that propofol was effective in reducing the incidence of postoperative emesis in pediatric outpatient strabismus surgery.
Weir
P M
PM
Section of Pediatric Anesthesiology, C.S. Mott Childrens Hospital, University of Michigan, Ann Arbor 48109.
Munro
H M
HM
Reynolds
P I
PI
Lewis
I H
IH
Wilton
N C
NC
D000758:Anesthesia; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006221:Halothane; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009609:Nitrous Oxide; D015742:Propofol / Q000627:therapeutic use; D011446:Prospective Studies; D013285:Strabismus / Q000601:surgery*; D014839:Vomiting / Q000209:etiology* / Q000517:prevention & control
D009609:Nitrous Oxide; D006221:Halothane; D015742:Propofol