title: 5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activity.
abstract: The ardeemins are a new family of secondary metabolites produced by submerged fermentation of a fungus which was isolated from a soil sample collected in Brazil. Based on taxonomic studies, the producing culture was identified as Aspergillus fischeri var. brasiliensis strain AB 1826M-35. 5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent vinblastine in multidrug resistant human tumor cells.
authors: Abbott Laboratories, Abbott Park, Illinois 60064.
authors: J P
authors: JP
authors: Karwowski
authors: M
authors: M
authors: Jackson
authors: R R
authors: RR
authors: Rasmussen
authors: P E
authors: PE
authors: Humphrey
authors: J B
authors: JB
authors: Poddig
authors: W L
authors: WL
authors: Kohl
authors: M H
authors: MH
authors: Scherr
authors: S
authors: S
authors: Kadam
authors: J B
authors: JB
authors: McAlpine
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D005285:Fermentation; D006571:Heterocyclic Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D011744:Pyrimidinones / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D006571:Heterocyclic Compounds; D011744:Pyrimidinones; C080891:5-N-acetylardeemin; D014747:Vinblastine