Drug-induced dystonia in a patient with C4 quadriplegia. Case report.
Prochlorperazine, a piperazine phenothiazine, is a commonly used anti-emetic that blocks dopamine receptors in the central nervous system. Prochlorperazine causes various extrapyramidal syndromes, with the incidence in the inpatient population estimated to be 0.5 to 0.8%. These side effects are typically manifested by motor dysfunction and easily observed on physical examination. We report the case of an 18-year-old male with C4 complete quadriplegia who developed an acute dystonic reaction isolated to the tongue during short-term treatment with prochlorperazine. This case demonstrates the importance of maintaining a high level of suspicion in the spinal cord population, considering that many key physical findings may be absent below the level of function.
Reecer
M V
MV
Department of Physical Medicine and Rehabilitation, Ohio State University, Columbus 43210-1290.
Clinchot
D M
DM
Tipton
D B
DB
D000293:Adolescent; D004155:Diphenhydramine / Q000627:therapeutic use; D004421:Dystonia / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D011346:Prochlorperazine / Q000009:adverse effects*; D011782:Quadriplegia / Q000534:rehabilitation*; D014059:Tongue
D004155:Diphenhydramine; D011346:Prochlorperazine