The use of angiostatic steroids to inhibit cartilage destruction in an in vivo model of granuloma-mediated cartilage degradation.
Angiogenesis is an important component of the development of chronic inflammatory diseases such as rheumatoid arthritis. It is known that clinically used anti-rheumatic drugs exert, in part, effects on the angiogenic response. Little work, however, has investigated the potential of experimental angiostatic therapies in chronic inflammatory disease models. The effect of one such angiostatic treatment, cortisone combined with heparin, was tested in an in vivo model of granuloma-mediated cartilage degradation. Angiostatic treatment significantly retarded the growth of granulomatous tissue, mononuclear cell influx into the granuloma, and the degradation of juxtaposed cartilage. This correlated with a decrease in the vascularity of the granulomatous tissue. Modulation of this component of pathogenesis of "angiogenesis-dependent disease" may be useful as a new therapeutic approach.
Colville-Nash
P R
PR
Department of Experimental Pathology, Medical College of St. Bartholomew's Hospital, London, UK.
el-Ghazaly
M
M
Willoughby
D A
DA
D000818:Animals; D002356:Cartilage / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D003348:Cortisone / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006493:Heparin / Q000494:pharmacology* / Q000627:therapeutic use; D006909:Hydroxyproline / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar
D006493:Heparin; D006909:Hydroxyproline; D003348:Cortisone