Acanthosis nigricans and hyperandrogenism in a pregnancy complicated by diabetes.
BACKGROUND
Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy.


METHODS
A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery.


CONCLUSIONS
This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.
Gemer
O
O
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
Segal
S
S
Segal
O
O
Zohav
E
E
Sassoon
E
E
D000052:Acanthosis Nigricans / Q000209:etiology*; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D007333:Insulin Resistance / Q000502:physiology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood*
D007328:Insulin; D013739:Testosterone