A prospective study of HIV-seropositive asymptomatic women of childbearing age in a developing country.
An observational study of 140 HIV-seropositive asymptomatic women of childbearing age was conducted in Haiti from 1984 to 1992 as part of a larger natural history study. Forty-four women were pregnant or became pregnant during the study period. The progression to HIV-related disease, AIDS, and mortality from AIDS was compared in the pregnant and nonpregnant cohorts. The mean follow-up time was 44 months. Overall, 32 of the 140 women (38%) developed AIDS, and 26 (19%) died from AIDS during the study period, with a cumulative AIDS incidence rate of 16% at 3 years after study entry. There was a trend toward earlier manifestation of HIV-related symptoms among the pregnant cohort, but no significant difference was observed in the rate of progression to AIDS or death between the pregnant and nonpregnant women.
Deschamps
M M
MM
Haitian Study Group on Kaposi's Sarcoma and Opportunistic Infection (GHESKIO), Port-au-Prince.
Pape
J W
JW
Desvarieux
M
M
Williams-Russo
P
P
Madhavan
S
S
Ho
J L
JL
Johnson
W D
WD
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001835:Body Weight; D005260:Female; D006679:HIV Seropositivity / Q000150:complications / Q000503:physiopathology*; D006205:Haiti; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology; D011446:Prospective Studies; D016019:Survival Analysis; D013997:Time Factors