title: Sex-linkage of the chicken ornithine transcarbamylase gene.
abstract: The chicken ornithine transcarbamylase gene has been mapped to the short arm of the Z chromosome, near the centromere. Radioactive in situ hybridization was performed using a human cDNA clone, and chromosomes were scored for silver grain accumulation. This represents the first documented case of a mammalian X-linked gene also being sex-linked in an avian species. The significance of this finding in the context of sex chromosome evolution is briefly discussed. Further, differential sex-related OTC expression, whereby females (ZW) consistently produce higher levels of the enzyme than males (ZZ), must imply a peculiar mode of OTC transcription regulation.
authors: Department of Human Genetics, University of Würzburg, Germany.
authors: M
authors: M
authors: Dominguez-Steglich
authors: M
authors: M
authors: Schmid
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007621:Karyotyping; D008297:Male; D009954:Ornithine Carbamoyltransferase / Q000235:genetics* / Q000378:metabolism; D014960:X Chromosome
chemical_list: D009954:Ornithine Carbamoyltransferase