Is aggressive heparinization necessary for elective PTCA?
The optimal level of heparin anticoagulation for elective PTCA is unknown. To determine if PTCA complications are related to the level of anticoagulation, serial ACT values were prospectively measured in 189 patients undergoing 201 elective PTCA procedures. The mean heparin dose before balloon inflation (pre-inflation) was 10,100 units, and the mean dose per procedure was 13,200 units. The mean pre-inflation ACT was 295 sec, but was < 300 sec in more than 50% of patients. Acute complications were not related to any ACT parameter and the development of new intracoronary thrombus was not observed. In elective PTCA procedures, the routine monitoring of ACT values is unnecessary when standard heparin doses are used.
Frierson
J H
JH
Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195.
Dimas
A P
AP
Simpfendorfer
C C
CC
Pearce
G
G
Miller
M
M
Franco
I
I
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D003328:Coronary Thrombosis / Q000097:blood / Q000453:epidemiology / Q000628:therapy; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D008991:Monitoring, Physiologic / Q000379:methods; D011446:Prospective Studies; D014914:Whole Blood Coagulation Time
D006493:Heparin