Effect of Sairei-to on gentamicin nephrotoxicity in rats.
The effect of Sairei-to, an oriental traditional medicine, against gentamicin nephrotoxicity was examined in gentamicin nephrotoxicity rat models. Gentamicin nephrotoxicity was induced by s.c. injection of gentamicin (100 mg/kg/day, for 3 days) in male Sprague-Dawley rats. Renal functions of two rat groups were compared, one eating rat chow containing 2.5% Sairei-to, the other eating normal rat chow. Sairei-to administration reduced the increase of urinary N-acetyl-beta-D-glucosaminidase (NAG) and protein excretion, and decreased creatinine clearance induced by gentamicin. Gentamicin increased renal cortical malondialdehyde (MDA) concentration in normal diet group but not in the Sairei-to diet group. The renal cortical gentamicin concentration was not different between the two groups. In conclusion, Sairei-to shows reno-protective action against gentamicin nephrotoxicity, possibly through its anti-oxidant action.
Ohno
I
I
Shibasaki
T
T
Nakano
H
H
Matsuda
H
H
Matsumoto
H
H
Misawa
T
T
Ishimoto
F
F
Sakai
O
O
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D003404:Creatinine / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005839:Gentamicins / Q000378:metabolism / Q000633:toxicity*; D007672:Kidney Cortex / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D011507:Proteinuria / Q000188:drug therapy / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D005839:Gentamicins; C080903:sairei-to; D003404:Creatinine; D000118:Acetylglucosaminidase