Diltiazem stimulates parathyroid hormone secretion in vivo whereas felodipine does not.
The impact of two calcium channel blockers of different structure, diltiazem and felodipine, on PTH secretion was studied under hyper- and hypocalcemic conditions. Six healthy volunteers were investigated before and after treatment with felodipine, then after treatment with diltiazem. Under each of these three conditions, they received first a calcium infusion (0.109 mmol/kg over 130 min). Blood was drawn every 5-10 min for measurements of Ca2+ and intact PTH concentrations, and urine was collected over the infusion periods for measurements of calcium and creatinine. Basal levels of Ca2+ and intact PTH concentrations were similar under the three conditions. During calcium infusion, Ca2+ increased linearly from 1.27 to 1.51 mmol/L during the control period. Based on the whole response curve, Ca2+/time, this rise was less marked (P < 0.002) during each of the calcium channel blocker periods than under control conditions, although the three values of urinary calcium excretion were similar. In addition, PTH secretion was less suppressed on diltiazem than on felodipine therapy or during the control period (P < 0.04). During EDTA infusion, Ca2+ decreased in a linear way from 1.27 to 1.07 mmol/L during the control period. Based on the whole response curve, Ca2+/time, this decrease was more marked during felodipine than during diltiazem treatment or in the control period (P < 0.001). Although Ca2+ concentrations did not differ between the control and diltiazem periods, PTH levels were 1.3-fold higher (P < 0.0001) during diltiazem, but similar in the control and felodipine periods. These data demonstrate that diltiazem, but not felodipine, stimulates PTH secretion in vivo in man, with a maximal effect observed under hypocalcemic conditions.
Villiger
L
L
Policlinic of Medicine, University Hospital, Bern, Switzerland.
Casez
J P
JP
Takkinen
R
R
Jaeger
P
P
D000328:Adult; D000704:Analysis of Variance; D002118:Calcium / Q000097:blood / Q000494:pharmacology; D004110:Diltiazem / Q000009:adverse effects / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology; D015736:Felodipine / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*
D010281:Parathyroid Hormone; D004492:Edetic Acid; D004110:Diltiazem; D015736:Felodipine; D002118:Calcium