Hypothesis: cartilage catabolic cofactors in human arthritis.
Cartilage degradation in rheumatoid arthritis (RA) and osteoarthritis (OA) is commonly thought to be mediated by interleukin 1 (IL-1) and tumor necrosis factor (TNF). However, recent new evidence suggests that IL-1 and TNF on their own do not mediate all the cartilage changes seen in RA and OA. We propose that cartilage degradation is mediated by a complex network of cytokines, including IL-1, TNF and at least one cofactor present in synovial fluid.
Hollander
A P
AP
Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, PQ, Canada.
Dieppe
P A
PA
Atkins
R M
RM
Elson
C J
CJ
D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D010003:Osteoarthritis / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha