Glycosylated derivatives of benzophenone, benzhydrol, and benzhydril as potential venous antithrombotic agents.
A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structure-activity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or benzhydrol moiety, and specifically those having the beta-D-xylopyranosyl structure in the sugar moiety, were good antithrombotic agents in a rat model of venous thrombosis.
Bellamy
F
F
Laboratoires Fournier S.A., Centre de Recherche, Daix, France.
Horton
D
D
Millet
J
J
Picart
F
F
Samreth
S
S
Chazan
J B
JB
D000284:Administration, Oral; D000818:Animals; D001559:Benzhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001577:Benzophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000627:therapeutic use; D006031:Glycosylation; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013924:Thrombophlebitis / Q000188:drug therapy
D001559:Benzhydryl Compounds; D001577:Benzophenones; D005343:Fibrinolytic Agents