[Synthesis and biological activity of 1,5-diaryl-3-alkylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones and 1,5-diaryl-4-carboxymethyltetrahydropyrrol-2,3-diones].
By interaction of alpha-ketoglutaric acid with Schiff bases 1,5-diaryl-3-arylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones 1 were obtained. Hydrolysis of the latter, carried out with hydrochloride acid gave 1,5-diaryl-3-hydroxy-4-carboxymethyl-2,5-dihydropyrrol-2-ones 2. On treatment of 2 with aryl-amines the starting compounds 1 were yielded. All compounds were tested for their antiphlogistic activity.
Gein
V L
VL
Pharmazeutisches Institut, Perm, Russland.
Popov
A V
AV
Kolla
W E
WE
Popova
N A
NA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002351:Carrageenan; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D007928:Lethal Dose 50; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; D011760:Pyrrolidinones; D002351:Carrageenan
Synthese und biologische Aktivität von 1,5-Diaryl-3-alkylamino-4-carboxymethyl-2,5-dihydropyrrol-2-onen und 1,5-Diaryl-4-carboxymethyltetrahydropyrrol-2,3-dionen.