title: Periodic respiration in patients with heart failure.
abstract: Patients with heart failure are known to demonstrate periodic respiration (PR) during sleep. The factors causing PR are not well known. We therefore studied 20 patients (aged 18-66 years) with idiopathic dilated cardiomyopathy. Full-night polysomnography and evaluation of respiration and transcutaneous oxygen saturation were performed. Hypercapnic ventilatory response (HCVR) was evaluated during daytime. The patients showed PR for 25 +/- 26% (mean +/- standard deviation) of total sleep time. During PR, oxygen desaturated 7.1 +/- 4.6%. Sleep was impaired. HCVR was normal. Oxygen desaturation during PR was predicted by HCVR (r = 0.47, P < 0.05) and left atrial diameter (r = 0.60, P < 0.05). The time period of PR expressed as a fraction of total sleep time was correlated with HCVR (r = 0.45, P < 0.05) and left atrial diameter (r = 0.51, P < 0.05). In conclusion, PR with oxygen desaturation, arousals, and impaired sleep was observed in stable heart failure. HCVR and left heart dimensions were related to PR. These findings confirm the concept of a feedback loop describing respiratory control in PR.
authors: Abteilung für Kardiologie und Pneumologie, Universität Göttingen.
authors: S
authors: S
authors: Andreas
authors: B
authors: B
authors: von Breska
authors: E
authors: E
authors: Kopp
authors: H R
authors: HR
authors: Figulla
authors: H
authors: H
authors: Kreuzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000503:physiopathology*; D005246:Feedback; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000209:etiology; D006985:Hyperventilation / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012123:Pulmonary Ventilation; D012044:Regression Analysis; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology; D013147:Spirometry