[The connection between the content of metallothioneins in the bone marrow and liver and the survivability of irradiated mice after cadmium chloride administration].
The survival rate of mice gamma-irradiated at different times after administration of Cd2+ (0.75 mg/kg) was shown to be tightly connected with the amount of metallothioneins induced by this heavy metal in the bone marrow (r = 0.96). The connection between the amount of metallothioneins in the liver and the survival rate was less pronounced.
Koterov
A N
AN
Sazykin
A Iu
AIu
Filippovich
I V
IV
D000818:Animals; D001853:Bone Marrow / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects*; D002104:Cadmium / Q000008:administration & dosage*; D019256:Cadmium Chloride; D002712:Chlorides / Q000008:administration & dosage*; D003609:Dactinomycin / Q000008:administration & dosage; D005720:Gamma Rays; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D008668:Metallothionein / Q000032:analysis / Q000187:drug effects* / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000378:metabolism* / Q000401:mortality; D013997:Time Factors
D002712:Chlorides; D002104:Cadmium; D003609:Dactinomycin; D008668:Metallothionein; D019256:Cadmium Chloride
Sviaz' mezhdu soderzhaniem metallotioneinov v kostnom mozge, pecheni i vyzhivaemost'iu obluchennykh mysheĭ posle vvedeniia khloristogo kadmiia.