HTLV-1 sequences in lymphocytes of a patient with non-tropical spastic tetraparesis and her asymptomatic husband.
We describe a 65-year-old woman born and living in Northern Italy affected by non tropical spastic tetraparesis and her asymptomatic husband presenting HTLV-1 sequences in their lymphocytes detected by polymerase chain reaction (PCR). We discuss the significance of the case and the mechanism involved in HTLV-1 infection and the relationship with neurological disorders, stressing that this case is the first reported in Italy.
Manca
N
N
Institute of Microbiology, University of Brescia, Italy.
Gelmi
M
M
Mattioli
F
F
Gargiulo
F
F
Terlenghi
L
L
Pirali
F
F
Turano
A
A
D015139:Blotting, Southern; D015153:Blotting, Western; D002478:Cells, Cultured; D015342:DNA Probes; D004279:DNA, Viral / Q000097:blood / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015752:Genes, env; D016355:Genes, pX; D015751:Genes, pol; D015481:HTLV-I Antibodies / Q000097:blood; D015486:HTLV-I Antigens / Q000097:blood; D015490:HTLV-I Infections / Q000175:diagnosis / Q000382:microbiology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D010243:Paralysis / Q000175:diagnosis / Q000382:microbiology*; D016133:Polymerase Chain Reaction
D015342:DNA Probes; D004279:DNA, Viral; D015481:HTLV-I Antibodies; D015486:HTLV-I Antigens