title: Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man.
abstract: Changes in the oxygenation state of brain hemoglobin during mental work were monitored in real time (time resolution: 1 s) using near-infrared spectrophotometry in 14 healthy volunteers. In a younger group (age range 22-30 years, n = 12), the subjects finding difficulty in solving a problem were accompanied by significant increases in both oxygenated hemoglobin and total hemoglobin, while the subjects making a correct answer without difficulty showed no significant changes in hemoglobin oxygenation. When compared with those younger subjects, observations on the older subject demonstrated a decrease in oxygenated hemoglobin and a reciprocal increase in deoxygenated hemoglobin, unaccompanied by changes in total hemoglobin.
authors: Department of Pediatrics, School of Medicine, Hokkaido University, Sapporo, Japan.
authors: Y
authors: Y
authors: Hoshi
authors: M
authors: M
authors: Tamura
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D004569:Electroencephalography; D005260:Female; D006339:Heart Rate; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000032:analysis; D011340:Problem Solving; D013055:Spectrophotometry, Infrared; D013850:Thinking / Q000502:physiology*; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins