title: Alterations of glial fibrillary acidic protein mRNA level in the aging brain and in senile dementia of the Alzheimer type.
abstract: The GFAP mRNA levels were compared to the density of the senile plaques (SP) in postmortem brain samples of 8 cases, either non-demented or affected by senile dementia of the Alzheimer type. In the frontal neocortex, the GFAP mRNA level is not affected, even if SP are present. In the temporal neocortex, a positive correlation between GFAP mRNA level and SP density was highly significant. This shows that in this area, astrocytes are altered at transcriptional or post-transcriptional levels, or both. The different responses of this astrogliosis marker in each area may be related to the loss of specific neurotransmitter system.
authors: INSERM U 282, Hôpital Henri Mondor, Creteil, France.
authors: G
authors: G
authors: Le Prince
authors: P
authors: P
authors: Delaere
authors: C
authors: C
authors: Fages
authors: C
authors: C
authors: Duyckaerts
authors: J J
authors: JJ
authors: Hauw
authors: M
authors: M
authors: Tardy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D001345:Autoradiography; D015152:Blotting, Northern; D001923:Brain Chemistry / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis*; D013702:Temporal Lobe / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D012333:RNA, Messenger