[Ionization energy and glycoside bond rupture energy of nucleosides, suppressing the reproduction of the human immunodeficiency virus (HIV)].
By photoionization mass spectrometry the energy characteristics were investigated for a series of nucleosides whose triphosphates possess anti-HIV activity. The electron-donor ability (a value reciprocal to ionization energy) does not correlate with the biological activity of corresponding nucleotides. The energy of glycoside bond rupture depended on modification in deoxyribose.
Orlov
V M
VM
Pustobaev
V N
VN
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry*; D006678:HIV; D013058:Mass Spectrometry; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology
D000998:Antiviral Agents; D006027:Glycosides; D009705:Nucleosides
Energii ionizatsii i énergii razriva glikozidnoĭ sviazi nukleozidov, podavliaiushchikh reproduktsiiu virusa immunodefitsita cheloveka (VICh).