title: Endothelin-1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase. Evidence for involvement in stimulation of mitogenesis.
abstract: The mechanism whereby endothelin stimulates mitogenesis of vascular smooth muscle cells is not understood. Here we show that endothelin-1 stimulates phospholipase D by a protein kinase C and tyrosine kinase dependent mechanism, and present evidence that implicate the phosphatidic acid formed by phospholipase D in the mitogenic response.
authors: Department of Pharmacology and Therapeutics, University of Leicester, UK.
authors: L C
authors: LC
authors: Wilkes
authors: V
authors: V
authors: Patel
authors: J R
authors: JR
authors: Purkiss
authors: M R
authors: MR
authors: Boarder
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D016232:Endothelins / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D010739:Phospholipase D / Q000378:metabolism*; D011493:Protein Kinase C / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
chemical_list: D016232:Endothelins; D014316:Tritium; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C; D010739:Phospholipase D; D013936:Thymidine