title: Endothelium releases more von Willebrand factor and tissue-type plasminogen activator upon venous occlusion in patients with liver cirrhosis than in normals.
abstract: Venous occlusion was used in 8 patients with liver cirrhosis and in 10 normals to investigate the pathomechanism of long-term elevation of plasma von Willebrand factor antigen (vWFAg) in liver cirrhosis. The following parameters were determined at baseline, and immediately, 60 min and 24 h after 10 min venous occlusion: vWFAg, ristocetin cofactor (RiCoF), in vitro platelet retention (Adeplat T), and tissue-type plasminogen activator (t-PA). Every baseline value in the liver cirrhosis group was significantly higher than in the controls. In both groups the 10-min values were significantly higher than their corresponding baseline results. Hence, comparing the two groups, in liver cirrhosis a significantly higher release of vWFAg and t-PA could be observed. These findings suggest on the one hand that the increased release contributes substantially to the sustained elevation of plasma vWF level in liver cirrhosis. On the other hand, the results indicate that not only the vascular surface of the diseased liver but most probably the total endothelium plays an important role in this phenomenon.
authors: 2nd Department of Medicine, University Medical School, Debrecen, Hungary.
authors: I
authors: I
authors: Tornai
authors: J
authors: J
authors: Hársfalvi
authors: Z
authors: Z
authors: Boda
authors: M
authors: M
authors: Udvardy
authors: G
authors: G
authors: Pfliegler
authors: K
authors: K
authors: Rak
mesh_terms: D000328:Adult; D003250:Constriction; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010959:Tissue Plasminogen Activator / Q000378:metabolism*; D014680:Veins; D014841:von Willebrand Factor / Q000032:analysis / Q000378:metabolism*
chemical_list: D014841:von Willebrand Factor; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator