Effect of plasma exchange in a patient with prolonged deep coma from thrombotic thrombocytopenic purpura.
The clinical, laboratory and instrumental data of a patient with thrombotic thrombocytopenic purpura (TTP) are reported in detail, with reference to an articulated therapeutic regimen including plasma exchange, high-dose methylprednisolone and dipiridamole. Particular emphasis is placed on the dramatic improvement obtained with this treatment despite a very delayed diagnosis and prolonged, severe neurological involvement. A short discussion and review of the literature concerning the role of plasma-exchange in the treatment of TTP is reported.
Mascaro
G
G
Servizio di Immunoematologia e Trasfusionale, Ospedale Maggiore di Novara.
Alleva
S
S
Airoldi
G
G
Antonini
C
C
Pelosi
G
G
Mancini
S
S
D000208:Acute Disease; D001241:Aspirin / Q000008:administration & dosage; D003128:Coma / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy; D004176:Dipyridamole / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications / Q000628:therapy*
D004176:Dipyridamole; D001241:Aspirin; D008775:Methylprednisolone