Adenine dinucleotide-mediated cytosolic free Ca2+ oscillations in single hepatocytes.
Single rat hepatocytes microinjected with aequorin respond to Ca(2+)-mobilizing agonists, including ADP and ATP, with oscillations in cytosolic free Ca2+. We show here that single rat hepatocytes also respond to the adenine dinucleotides Ap3A and Ap4A with Ca2+ oscillations which resemble those induced by ADP and ATP.
Green
A K
AK
Department of Human Anatomy and Cell Biology, University of Liverpool, UK.
Dixon
C J
CJ
McLennan
A G
AG
Cobbold
P H
PH
Fisher
M J
MJ
D000331:Aequorin; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015226:Dinucleoside Phosphates / Q000502:physiology*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D015226:Dinucleoside Phosphates; D000331:Aequorin; C020733:diadenosine tetraphosphate; C011440:diadenosine triphosphate; D002118:Calcium