title: Immunohistochemical staining for CA-125 in fallopian tube carcinomas.
abstract: From 1981-1991, 15 patients with primary fallopian tube carcinomas were treated at the University of Kentucky Medical Center. Immunohistochemical staining for CA-125 was performed on tumor specimens from all cases. Thirteen tumors (87%) stained positively for CA-125. Antigen staining was most intense in the apical portions of carcinoma cells. Serum CA-125 levels were measured in 5 patients and were elevated in 4 (80%). There was a positive correlation between tumor and serum antigen expression in these cases. Serum CA-125 levels accurately reflected disease status in the patients studied. These data suggest that CA-125 is a useful marker in patients with fallopian tube carcinoma. Immunohistochemical localization of CA-125 in tumor tissue should predict which patients will benefit most from serial antigen determinations.
authors: Department of Obstetrics and Gynecology, University of Kentucky Medical Center, Lexington 40536.
authors: L E
authors: LE
authors: Puls
authors: D D
authors: DD
authors: Davey
authors: P D
authors: PD
authors: DePriest
authors: H H
authors: HH
authors: Gallion
authors: J R
authors: JR
authors: van Nagell
authors: J E
authors: JE
authors: Hunter
authors: E J
authors: EJ
authors: Pavlik
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis* / Q000097:blood; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate