title: Crude extracts and two linear diterpenes from Cystoseira balearica and their activity.
abstract: Crude extracts of Cystoseira balearica were submitted to pharmacological investigations. The chloroform-methanol residue caused relaxation of the rat aortic musculature and an inhibitory action on the guinea pig atria. The fractionation of this crude extract gave two active diterpenoids, eleganolone (1) and elegandiol (2), the latter has not previously been isolated from this alga. These pure components, never before tested, showed a higher activity when compared with the crude residue.
authors: Dipartimento di Scienze dell' Ambiente e del Territorio, Università degli Studi di Pisa, Italy.
authors: F
authors: F
authors: Della Pietá
authors: A R
authors: AR
authors: Bilia
authors: M C
authors: MC
authors: Breschi
authors: F
authors: F
authors: Cinelli
authors: I
authors: I
authors: Morelli
authors: R
authors: R
authors: Scatizzi
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D000459:Phaeophyceae / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014132:Trachea / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D004224:Diterpenes; C027930:eleganolone; C081083:elegandiol