Alterations to the pattern of ultrasonic calling after prenatal exposure to aluminium sulfate.
Pregnant CBA mice were exposed to aluminium sulfate at a dose of 200 mg/kg body wt injected intraperitoneally during Days 10 to 13 of gestation. We used a variety of ethological measures, which have been shown to be sensitive indicators of toxicants, to assess effects on the mother and the behavioral development of pups. Prenatal aluminium resulted in a reduction in the rate of ultrasonic calling by pups accompanied by a shift in the timing of peak calling; treated pups exhibited decreased growth and delays in neurobehavioral development. The treatment received by a pup's foster mother was also found to influence development. We recommend ultrasonic calling as a sensitive measure in studies of behavioral teratogenicity.
Rankin
J
J
Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom.
Manning
A
A
D000014:Abnormalities, Drug-Induced; D000534:Alum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011297:Prenatal Exposure Delayed Effects; D014828:Vocalization, Animal / Q000187:drug effects*
D000534:Alum Compounds