What is an idiotype?
Idiotypy is an important concept with significant practical implications for the manipulation of B- and T-cell clones. However, this potential depends on a correct identification of idiotypy and the development of appropriate reagents. Current knowledge of the structure and polymorphism within the Ig loci reveals that several idiotypic paradigms are based on isotypic or allotypic structures rather than supposed crossreactive idiotypes.
Jefferis
R
R
Dept of Immunology, Medical School, Edgbaston, Birmingham, UK.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D003429:Cross Reactions; D005803:Genes, Immunoglobulin; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D012217:Rheumatoid Factor / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D012217:Rheumatoid Factor