title: Human reciprocal translocations: is the unbalanced mode at birth predictable?
abstract: Two methods of prediction for the risk of unbalance at birth were tested on a large data base of reciprocal translocation (1376 families): the pachytene diagram predictive method (PDP method) and the discriminant method (D method). These method succeeded in correctly predicting the segregation mode in 66% of the data for the PDP method and in 80% of the data for the D method. The quality of chromosome material (in particular R bands) must be taken into account for more accurate prediction. Some difficulties still exist in predicting the 3:1 tertiary segregation mode, which can frequently be incorrectly classified as the adjacent 1 mode.
authors: Genetics Laboratory, Medical School, Joseph Fourier University, Grenoble, La Tronche, France.
authors: C
authors: C
authors: Cans
authors: O
authors: O
authors: Cohen
authors: M A
authors: MA
authors: Mermet
authors: J
authors: J
authors: Demongeot
authors: P
authors: P
authors: Jalbert
mesh_terms: D006801:Humans; D011237:Predictive Value of Tests; D012306:Risk; D013223:Statistics as Topic / Q000379:methods; D014178:Translocation, Genetic