Graft failure following neutrophil-specific alloantigen mismatched allogeneic BMT.
We report a case of unexplained graft failure in a 33-year-old man who received an allogeneic bone marrow graft that contained a donor-recipient mismatch involving the highly immunogenic NA1 neutrophil-specific alloantigen system. Laboratory and clinical data suggest that an alloimmune process related to the neutrophil alloantigen mismatch played a role in the development of the graft failure.
Klumpp
T R
TR
Bone Marrow Transplantation Program, Temple University Comprehensive Cancer Center, Philadelphia, PA 19140.
Herman
J H
JH
Mangan
K F
KF
Macdonald
J S
JS
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007519:Isoantigens; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008297:Male; D009503:Neutropenia / Q000209:etiology / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D010641:Phenotype; D014019:Tissue Donors
D007519:Isoantigens; C067704:neutrophil-specific antigen NA1, human