Properties of genes involved in the control of isocitrate lyase production in Aspergillus nidulans.
The interaction between genes of Aspergillus nidulans conferring constitutive synthesis of isocitrate lyase (iclc A and iclcB) and fluoroacetate resistance (facB) has been investigated. Although facB mutants are unable to induce the glyoxylate cycle enzyme isocitrate lyase in response to acetate as sole carbon source, this phenotype was suppressed in recombinants of the type iclc;facB. The iclcA and iclcB mutations do not alter significantly the activities of eight enzymes of intermediary metabolism assayed. We conclude that the iclc genes are probably bona fide isocitrate lyase regulatory genes.
McCullough
W
W
Department of Biological and Biomedical Sciences, University of Ulster, Jordanstown, Northern Ireland, UK.
Shanks
A
A
D001233:Aspergillus nidulans / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005463:Fluoroacetates / Q000494:pharmacology; D005800:Genes, Fungal; D005809:Genes, Regulator; D007522:Isocitrate Lyase / Q000096:biosynthesis* / Q000235:genetics*; D009154:Mutation
D005463:Fluoroacetates; C014815:fluoroacetic acid; D007522:Isocitrate Lyase