[The biological activity of vitamin E].
The relative biopotency of alpha-(RRR(d)-, 2-ambo (dl)-and all-rac (dl)), beta-, gamma- and delta-tocopherol, tocotrienol homologues and tocopherol derivatives are summarized in the tables. The new United States Pharmacopoeia [USP] XXII-NFXVII (1990) does not mention the USP (International) Unit of the six different forms of alpha-tocopherol that has indicated the difference in biopotency between d-alpha-tocopherol and dl-(2- ambo)-alpha-tocopherol and been used for 40 years from 1950. Metabolic and bio-discrimination studies of tocopherols are necessary to determine the precise relative biopotency of d-(RRR)-and dl-(all-rac)-alpha tocopherol. The synergistic effect of all-rac-alpha- tocopherol with its 8 stereoisomers and the biotransformation from beta-, gamma-and delta-to alpha-tocopherol are also subjects for further study of the biological activity of tocopherols.
Kijima
S
S
Department of Research and Development, Eisai Co. Ltd.
D000818:Animals; D006801:Humans; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E