Assessment of genotoxicity of two anti-parkinsonian drugs (selegiline hydrochloride and bromocriptine mesylate) in vivo in mouse bone marrow cells.
Selegiline hydrochloride (1-deprenyl) and bromocriptine mesylate (2-bromo-alpha-ergocryptine) are two drugs that have shown considerable promise in the treatment of Parkinson's disease. The in vivo mouse bone marrow micronucleus assay was used to examine their clastogenic and cytotoxic potential in human clinical dose range. Our results indicate that both drugs failed to induce significant number of micronuclei and were not cytotoxic at any of the doses tested, in vivo in mouse bone marrow cells, at doses as high as 16-times the clinical dose used in humans.
Subramanya
K S
KS
Department of Chemistry, Massachusetts Institute of Technology, Cambridge.
Motimaya
A M
AM
Curry
P T
PT
Kitchin
R M
RM
D000704:Analysis of Variance; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D001971:Bromocriptine / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D012642:Selegiline / Q000633:toxicity*
D009153:Mutagens; D012642:Selegiline; D001971:Bromocriptine