title: Use of cocaine during the immediate prepartum period by childbearing women in Ohio.
abstract: Despite widespread concern about exposure of infants in utero to cocaine, population-based data regarding the prevalence of such exposures are limited. An official task force in Ohio called for studies to generate such data for that state. During three weeks in late 1990, urine was obtained within 48 hours of birth from 1,819 infants born in 25 Ohio hospitals randomly selected from a pool of hospitals accounting for over 80% of Ohio births. Maternal age, race/ethnicity, and residence information were collected so that results could not be linked to individual mothers or infants. Urines were screened for benzoylecgonine (BZE), a cocaine metabolite, using a commercially available immunoassay. The crude prevalence of BZE positivity was 2.0%. When adjusted for unequal cluster sizes and race/ethnicity, the prevalence was 1.4%. The adjusted prevalence for infants born to black mothers was 7.2%, for infants born to white mothers, 0.3%. Ninety-seven percent of the mothers whose infants tested positive were residents of a city of 20,000 or more people. The use of hospital maternity units as a basis for anonymous sampling, as demonstrated in this study, may be a useful model for other jurisdictions seeking population-based data concerning perinatal drug exposures. Such methods may be especially useful for trend studies and program evaluation. In this study, we found widely distributed prepartal cocaine usage in Ohio. Black newborns were significantly more likely than white newborns to show evidence of recent cocaine exposure.
authors: Division of Preventive Medicine, Ohio Department of Health.
authors: J M
authors: JM
authors: Moser
authors: V H
authors: VH
authors: Jones
authors: M L
authors: ML
authors: Kuthy
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D003042:Cocaine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D007118:Immunoassay; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D009820:Ohio / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000208:ethnology; D015995:Prevalence; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000208:ethnology; D044465:White People
chemical_list: C005618:benzoylecgonine; D003042:Cocaine