Noninvasive analysis of aldose reductase activities in rat testis: 3-FDG NMR spectroscopy and imaging.
Noninvasive investigation of aldose reductase activities in rat testis was performed using 3-fluoro-3-deoxy-D-glucose (3-FDG) and nuclear magnetic resonance (NMR) spectroscopy/imaging. Quantitative determination of testis aldose reductase activities, expressed as the sorbitol index, showed a value similar to that of brain. Sorbitol imaging demonstrated aldose reductase activities in testis to be confined primarily to the central region of this organ. The 3-FDG 19F NMR method appears to have clinical potential in the evaluation of testicular function, especially that of spermatogenesis, noninvasively.
Nakada
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Neurochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California.
Kwee
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IL
D000449:Aldehyde Reductase / Q000378:metabolism*; D000818:Animals; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013012:Sorbitol; D013737:Testis / Q000033:anatomy & histology / Q000201:enzymology*
D005462:Fluorine Radioisotopes; C007253:3-deoxy-3-fluoro-D-glucose; D013012:Sorbitol; D003847:Deoxyglucose; D000449:Aldehyde Reductase