Effect of various dietary constituents on gastrointestinal absorption of aluminum from drinking water and diet.
The influence of some frequent dietary constituents on gastrointestinal absorption of aluminum from drinking water and diet was investigated in mice. Eight groups of male mice received lactic (57.6 mg/kg/day), tartaric (96 mg/kg/day), gluconic (125.4 mg/kg/day), malic (85.8 mg/kg/day), succinic (75.6 mg/kg/day), ascorbic (112.6 mg/kg/day), citric (124 mg/kg/day), and oxalic (80.6 mg/kg/day) acids in the drinking water for one month. At the end of this period, animals were killed and aluminum concentrations in liver, spleen, kidney, brain, and bone were determined. All the dietary constituents significantly increased the aluminum levels in bone, whereas brain aluminum concentrations were also raised by the intake of lactic, gluconic, malic, citric, and oxalic acids. The levels of aluminum found in spleen were significantly increased by gluconic and ascorbic acids, whereas gluconic and oxalic acids also raised the concentrations of aluminum found in kidneys. Because of the wide presence and consumption of the above dietary constituents, in order to prevent aluminum accumulation and toxicity we suggest a drastic limitation of human exposure to aluminum.
Domingo
J L
JL
Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Reus, Spain.
Gomez
M
M
Sanchez
D J
DJ
Llobet
J M
JM
Corbella
J
J
D000535:Aluminum / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D000544:Alzheimer Disease / Q000139:chemically induced; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002264:Carboxylic Acids / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D004032:Diet; D005744:Gastric Acid / Q000378:metabolism; D005942:Gluconates / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D008293:Malates / Q000494:pharmacology; D008297:Male; D051379:Mice; D010070:Oxalates / Q000494:pharmacology; D019815:Oxalic Acid; D014018:Tissue Distribution; D014881:Water Supply / Q000032:analysis
D002264:Carboxylic Acids; D002614:Chelating Agents; D002951:Citrates; D005942:Gluconates; D007773:Lactates; D008293:Malates; D010070:Oxalates; D019343:Citric Acid; D019344:Lactic Acid; C030298:malic acid; D019815:Oxalic Acid; D000535:Aluminum; C030691:gluconic acid