title: Pradimicins L and FL: new pradimicin congeners from Actinomadura verrucosospora subsp. neohibisca.
abstract: Pradimicin L, a new congener of pradimicin A having the D-glucosyl-D-thomosamine moiety at the C-5 position, was isolated from Actinomadura verrucosospora subsp. neohibisca subsp. nov. The structure of pradimicin L was deduced to be N-[[(5S,6S)-5-O-[4,6-dideoxy-4-(methylamino)-3-O-(beta-D-glucopyranosyl) - beta-D-galactopyranosyl]-5,6,8,13-tetrahydro-1,5,6,9,14-pentahydroxy-11- methoxy-3-methyl-8,13-dioxobenzo[a]naphthacene-2-yl]carbonyl ]-D-alanine by MS and NMR spectrometry and degradation studies. Pradimicin FL which has the D-serine moiety instead of D-alanine was produced by directed biosynthesis in D-serine-supplemented medium. Pradimicins L and FL have a broad spectrum of in vitro antifungal activity. Pradimicin L was equiactive to pradimicin A and pradimicin FL was more active than pradimicin L.
authors: Bristol-Myers Squibb Research Institute, Tokyo, Japan.
authors: K
authors: K
authors: Saitoh
authors: Y
authors: Y
authors: Sawada
authors: K
authors: K
authors: Tomita
authors: T
authors: T
authors: Tsuno
authors: M
authors: M
authors: Hatori
authors: T
authors: T
authors: Oki
mesh_terms: D000191:Actinomycetaceae / Q000737:chemistry*; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D000095643:Pradimicins and Benanomicins
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C058036:pradimicin A; D000095643:Pradimicins and Benanomicins; C080892:pradimicin L; C080893:pradimicin FL