title: Developmental changes in seizure susceptibility in carbonic anhydrase II-deficient mice and normal littermates.
abstract: Mice deficient in carbonic anhydrase II (CA II) were tested along with their normal littermates for susceptibility to seizures induced by flurothyl and loud sound at ages 10-180 days. In the flurothyl seizure model, CA II-deficient mice displayed increased resistance to clonic seizures from 32 to 90 days of age, whereas tonic-clonic seizures were suppressed at all ages. The mortality of CA II-deficient mice was significantly decreased at ages 19-40 days. The incidence of sound-induced seizures was very low and no difference between CA II-deficient and normal mice was found. The anticonvulsant effect of CA II deficiency appears to be dependent on seizure model and seizure type and to have age-specific characteristics.
authors: Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461.
authors: L
authors: L
authors: Velíŝek
authors: S L
authors: SL
authors: Moshé
authors: W
authors: W
authors: Cammer
mesh_terms: D000161:Acoustic Stimulation; D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D002256:Carbonic Anhydrases / Q000172:deficiency*; D004198:Disease Susceptibility; D005481:Flurothyl; D051379:Mice; D011930:Reaction Time; D012016:Reference Values; D012640:Seizures / Q000139:chemically induced / Q000209:etiology*
chemical_list: D005481:Flurothyl; D002256:Carbonic Anhydrases