[Chemical modification of nucleic acids and the mutagenicity of modified bases, with special reference to permanganate- and bisulfite-mediated modifications].
Methods for modifying nucleic acids and their components with permanganate and with bisulfite are reviewed, with emphasis on work developed by the author's group of investigators. N(4)Aminocytidine, a nucleoside analog obtainable on bisulfite-hydrazine modification of cytidine, is a potent mutagen, and the mechanism of its action in the mutagenesis is discussed.
Hayatsu
H
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Faculty of Pharmaceutical Sciences, Okayama University, Japan.
D008345:Manganese / Q000737:chemistry*; D017895:Manganese Compounds; D016296:Mutagenesis; D009696:Nucleic Acids / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D013447:Sulfites / Q000737:chemistry*
D017895:Manganese Compounds; D009696:Nucleic Acids; D010087:Oxides; D013447:Sulfites; C048856:permanganic acid; D008345:Manganese; C042345:hydrogen sulfite