title: [Osteosarcoma of the extremities metastatic at presentation. Results obtained with primary chemotherapy followed by simultaneous resection of the primary and metastatic lesion].
abstract: From September 1986 to September 1990 35 patients affected by osteosarcoma of the extremities with synchronous metastasis were treated with two cycles of high-dose methotrexate IV, cisplatin IA and adriamycin IV followed, in 22, by simultaneous resection of the primary and metastatic tumor. Six patients progressed and were not operated on, 7 patients with complete response of pulmonary nodules underwent surgical resection of the primary lesion. A complete histological examination of the resected specimens was always performed to evaluate the percentage of necrosis produced by chemotherapy on both the primary and metastatic tumor. After surgery the patients received 3 more cycles of the same drugs as used preoperatively plus ifosfamide. The histological response of the primary tumour was "good" (90% or more tumour necrosis) in 8 patients (27%) and "poor" (less than 90% of tumour necrosis) in 21 (73%) while in the 75 metastatic nodules the resulting necrosis was good in 18 (24%) and poor in 57 (74%). A good correlation between the histological response in the primary and metastatic tumour was observed. At an average follow-up of 30 months (R 12-60), 13 patients are alive, 10 disease-free, and 3 with uncontrolled disease. This data suggest that prognosis of osteosarcoma of the extremities with synchronous metastases remains poor even with a very aggressive treatment. Our results also seem to confirm the validity of the present strategy in the treatment of non metastatic osteosarcoma: to introduce new drugs postoperatively in patients poor responder can allows a better treatment of microscopic disease and can improve the prognosis for these patients.
authors: Sezione di Chemnioterapia dei Tumori, Istituto Ortopedico Rizzoli, Bologna.
authors: G
authors: G
authors: Bacci
authors: A
authors: A
authors: Briccoli
authors: S
authors: S
authors: Ferrari
authors: P
authors: P
authors: Ruggieri
authors: M
authors: M
authors: Avella
authors: R
authors: R
authors: Casadei
authors: A
authors: A
authors: Battistini
authors: P
authors: P
authors: Picci
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001132:Arm; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D006801:Humans; D007866:Leg; D008875:Middle Aged; D012516:Osteosarcoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome
vernacular_title: Osteosarcoma delle estremità con metastasi all'esordio. Risultati ottenuti con chemioterapia primaria seguita dall'intervento contemporaneo sulla lesione primitiva e metastatica.