The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin.
Six healthy male volunteers participated in a two-period, two-treatment study to determine the effect of chronic calcium carbonate administration on ciprofloxacin bioavailability. There was a mean reduction of 40% in Cmax and 43% in AUC when calcium carbonate was administered with ciprofloxacin, compared with ciprofloxacin alone (P < 0.05). There were no changes in either half-life or tmax. It is therefore recommended that patients being treated with ciprofloxacin for serious infections refrain from ingesting calcium supplements. If this is not possible, administration of ciprofloxacin 2 h before ingestion of the supplement is suggested.
Sahai
J
J
Department of Medicine, Ottawa General Hospital, Ontario, Canada.
Healy
D P
DP
Stotka
J
J
Polk
R E
RE
D000042:Absorption / Q000187:drug effects; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male
D002939:Ciprofloxacin; D002119:Calcium Carbonate