Some potential antitumor 2,2'-dipyridylamine Pt(II)/Pd(II) complexes with amino acids: their synthesis, spectroscopy, DNA binding, and cytotoxic studies.
Four new palladium(II) and platinum(II) complexes of formula [M(dipy)(AA)]+ (where dipy is 2,2'-dipyridylamine, AA is an anion of glycine or L-alanine, and M is Pd(II) or Pt(II)) have been synthesized and characterized with amino acids binding as bidentate ligands. These complexes are 1:1 electrolyte in conductivity water. Of the above four complexes, the two L-alanine complexes show ID50 values against P388 lymphocytic leukemia cells lower than cis-diamminedichloroplatinum(II), whereas the two glycine complexes show ID50 values higher than cisplatin. The interaction of calf thymus DNA with the above complexes shows significant spectral changes in the presence of [Pt(dipy)(gly)]Cl, [Pd(dipy)(ala)]Cl, and [Pt(dipy)(ala)]Cl and the mode of binding between these complexes and DNA seems to be noncovalent.
Paul
A K
AK
Department of Chemistry, Indian Institute of Technology, Bombay.
Mansuri-Torshizi
H
H
Srivastava
T S
TS
Chavan
S J
SJ
Chitnis
M P
MP
D015082:2,2'-Dipyridyl / Q000737:chemistry*; D000409:Alanine / Q000737:chemistry; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D002417:Cattle; D002945:Cisplatin / Q000627:therapeutic use; D004247:DNA / Q000378:metabolism*; D005998:Glycine / Q000737:chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D010984:Platinum / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D013053:Spectrophotometry
D000596:Amino Acids; D000970:Antineoplastic Agents; D010984:Platinum; D015082:2,2'-Dipyridyl; D010165:Palladium; D004247:DNA; D000409:Alanine; D002945:Cisplatin; D005998:Glycine