Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans.
The production of anti-tetanus toxoid (TT) antibody and anti-anti-TT (auto-anti-Id) antibody has been measured in three young and three old persons. Both antibodies were measured using ELISA. We found that: (i) the anti-TT response of old subjects was lower than that of young subjects, (ii) serum auto-anti-Id antibody concentration was higher in old compared with young humans before boosting with TT, and (iii) anti-TT antibodies from different humans shared Id cross-reactivity when tested with a rabbit anti-Id antibody. Thus, the serum anti-TT antibody response to boosting was inversely correlated with the serum level of auto-anti-Id. This conclusion is consistent with the view that the higher level of auto-anti-antibody in older subjects contributes to their impaired antibody response to TT.
Arreaza
E E
EE
Department of Medicine, Cornell University Medical College, New York 10021.
Gibbons
J J
JJ
Siskind
G W
GW
Weksler
M E
ME
D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology*; D003429:Cross Reactions; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007114:Immunization; D007117:Immunization, Secondary; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D008297:Male; D013745:Tetanus Toxoid / Q000276:immunology*; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007140:Immunoglobulin Fab Fragments; D013745:Tetanus Toxoid