Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys.
The distribution of calcitonin gene-related peptide (CGRP) immunoreactivity in the cavernous tissue and the erectile response to intracavernous injection of CGRP was investigated in 7 monkeys. Intracavernous CGRP increased cavernous arterial flow and induced cavernous smooth muscle relaxation and venous outflow occlusion. Intracavernous injection of CGRP antibody did not significantly change the erectile response to cavernous nerve stimulation. Histologic staining for CGRP immunoreactivity showed nerve fiber-like staining within the cavernous arterial wall and the cavernous smooth muscles. These data suggest that CGRP may contribute to penile erection in monkeys.
Stief
C G
CG
Department of Urology, University of California, San Francisco.
Benard
F
F
Bosch
R
R
Aboseif
S
S
Wetterauer
U
U
Lue
T F
TF
Tanagho
E A
EA
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*; D008254:Macaca nemestrina; D008297:Male; D010410:Penile Erection / Q000187:drug effects / Q000502:physiology*; D010413:Penis / Q000098:blood supply / Q000737:chemistry; D012039:Regional Blood Flow / Q000187:drug effects
D015740:Calcitonin Gene-Related Peptide