Properties of single Na(+)-activated K+ channels in cultured central neurons of the chick embryo.
Na(+)-activated K+ channels (IK[Na]) of cultured chick brainstem neurons do not run down following excision of inside-out patches, but this occurs within seconds to minutes in cultured chick olfactory bulb neurons. IK[Na] channels of chick brainstem neurons exhibit a main conductance state of 95-105 pS, and also express multiple sub-conductance states. These channels have complex kinetics, with multiple closed and main conductance states. The average lifetime of the main conductance state is not dependent on the Na+ concentration used to activate the channels.
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Department of Biological Science, Florida State University, Tallahassee 32306.
D000818:Animals; D001933:Brain Stem / Q000378:metabolism / Q000502:physiology; D002478:Cells, Cultured; D002642:Chick Embryo; D015640:Ion Channel Gating / Q000502:physiology; D007700:Kinetics; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D009830:Olfactory Bulb / Q000196:embryology / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism* / Q000502:physiology; D012964:Sodium / Q000502:physiology*
D015221:Potassium Channels; D012964:Sodium