Role of thermal trauma in experimental oral mucosal Candida infections in rats.
A model of candidosis in experimental rats was used to study the role of trauma in the aetiology of oral mucosal infections caused by Candida albicans. Standardised thermal trauma was delivered to the dorsum of the tongue of Sprague-Dawley rats and experimental candidosis was induced. Histologically, the site of trauma was invaded by hyphae earlier and more extensively than in control animals, leading to the conclusion that trauma facilitated the establishment of the C. albicans infections.
O'Grady
J F
JF
Section of Oral Medicine and Oral Surgery, School of Dental Science, University of Melbourne, Australia.
Reade
P C
PC
D000818:Animals; D002176:Candida albicans; D002180:Candidiasis, Oral / Q000209:etiology* / Q000473:pathology; D002455:Cell Division; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects*; D007249:Inflammation; D009061:Mouth Mucosa / Q000293:injuries*; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration; D014059:Tongue / Q000293:injuries / Q000382:microbiology; D014060:Tongue Diseases / Q000209:etiology / Q000382:microbiology / Q000473:pathology