Erythroderma, hair loss, and sinus histiocytosis with massive lymphadenopathy in a XYY-male.
This paper presents a case of sinus histiocytosis with massive lymphadenopathy (SHML) presenting as erythroderma in an XYY-male aged 27. The patient had little or no scalp, axillary, or pubic hair. Histologically, lymph nodes indicated dilatation of the sinuses with proliferation of benign-appearing histiocytes possessing abundant clear cytoplasm, admixed with giant cells and pericapsular fibrosis. Infiltrating histiocytes in the lymph nodes were OKM-1 (CD11b) positive, which is characteristic of monocyte-granulocyte lineages. In the present case, the abnormal presence of erythroderma, hair loss, SHML, and a chromosomal abnormality, XYY, were thought to be incidental features.
Tsukahara
T
T
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
Horiuchi
Y
Y
Ohkawa
T
T
Masuzawa
M
M
Nishiyama
S
S
Ohida
M
M
D000328:Adult; D000505:Alopecia / Q000150:complications* / Q000473:pathology; D003873:Dermatitis, Exfoliative / Q000150:complications* / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000473:pathology; D006801:Humans; D008199:Lymphadenitis / Q000150:complications* / Q000473:pathology; D008297:Male; D014997:XYY Karyotype