Accumulation of acetone in blood during long-term anaesthesia with closed systems.
During closed system anaesthesia with isoflurane, patients with a preoperative increase in blood concentration of acetone (> 10 mg litre-1) had a significantly greater concentration of acetone than patients with an initial normal blood concentration of acetone (P < 0.01). Flushing the closed system with a high flow of fresh gas had no effect on the blood concentration of acetone. Using a large fresh gas flow, there was no increase in blood acetone concentration. Acetone concentrations of about 50 mg litre-1 cause problems such as nausea and vomiting in the postoperative period. These symptoms occurred more frequently after closed system anaesthesia.
Strauss
J M
JM
Department of Anaesthesia III, Medizinische Hochschule Hannover, Germany.
Hausdörfer
J
J
D000096:Acetone / Q000097:blood*; D000764:Anesthesia, Closed-Circuit; D006801:Humans; D007530:Isoflurane; D011183:Postoperative Complications / Q000139:chemically induced; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D000096:Acetone; D007530:Isoflurane