A neural network model for kindling of focal epilepsy: basic mechanism.
A simple neural network model is proposed for kindling--the phenomenon of generating epilepsy by means of repeated electrical stimulation. The model satisfies Dale's hypothesis, incorporates a Hebb-like learning rule and has low periodic activity in absence of shocks. Many of the experimental observations are reproduced and some new experiments are suggested. It is proposed that the main reason for kindling is the formation of a large number of excitatory synaptic connections due to learning.
Mehta
M R
MR
Department of Physics, Indian Institute of Science, Bangalore, India.
Dasgupta
C
C
Ullal
G R
GR
D000818:Animals; D003198:Computer Simulation; D003491:Cybernetics; D004558:Electric Stimulation; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D007696:Kindling, Neurologic / Q000502:physiology*; D007858:Learning / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D013569:Synapses / Q000502:physiology