[DNA analysis in stomach cancer--correlation of aneuploidy with tumor site].
The DNA status and the proliferative activity was determined in 37 gastric carcinomas applying computerized image analysis. Aneuploidy was found in 51.4% (n = 19) of the tumors. Comparing diploid and aneuploid lesions the latter ones had statistically significant increased DNA amount, DNA index and proliferative rate (7.4 pg, 1.03 and 16.4% versus 12.8 pg, 1.78 and 30.7%; p < 0.05). Aneuploidy occurred more frequently in tumors at proximal sites (p < 0.05), but was not associated with histological type, differentiation and tumor stage. The prognostic impact of DNA aneuploidy remains controversial, since tumor aggressiveness per se is not directly related to aneuploidy.
Jähne
J
J
Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover.
Urmacher
C
C
Cordon-Cardo
C
C
Meyer
H J
HJ
Pichlmayr
R
R
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002453:Cell Cycle / Q000502:physiology; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
D004273:DNA, Neoplasm
DNA-Analyse beim Magencarcinom--Korrelation von Aneuploidie mit der Tumorlokalisation.