title: Correlation of lipophilicity to biodistribution of 99mTc-labelled aminothiols.
abstract: A series of 99mTc-DADT complexes substituted with heterocyclic amines were synthesized and tested for their ability to cross the BBB. Each 99mTc-DADT complex analysed by HPLC was found to consist of two epimers. The more lipophilic epimers were biodistributed in mice. The data demonstrated a significant brain uptake (3-12% dose/g whole brain) and a high lung accumulation (11-85% dose/g) at 2 min p.i. Between the partition coefficients of the technetium complexes, a linear correlation for lung accumulation was observed, while a parabolic curve for brain uptake was found.
authors: Radiopharmaceuticals Laboratory, Institute of Radioisotopes and Radiodiagnostics, NCSR Demokritos, Attiki, Greece.
authors: M
authors: M
authors: Papadopoulos
authors: E
authors: E
authors: Chiotellis
authors: A
authors: A
authors: Varvarigou
authors: S
authors: S
authors: Mastrostamatis
authors: C
authors: C
authors: Cotsyfakis
authors: H
authors: H
authors: Vavouraki
authors: S
authors: S
authors: Stathaki
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002851:Chromatography, High Pressure Liquid; D008055:Lipids; D051379:Mice; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D008055:Lipids; D015609:Organotechnetium Compounds; D013438:Sulfhydryl Compounds