The human gene for the zona pellucida glycoprotein ZP3 and a second polymorphic locus are located on chromosome 7.
Southern blot analysis of genomic DNA and gene-cloning experiments have recently shown that the human ZP3 gene is not a single-copy gene. The human genome harbors sequences encoding a protein of 424 amino acids and, in addition, a polymorphic locus with the potential to give rise to a probably nonfunctional polypeptide of 372 residues. In this report it is shown, by screening of a panel of human x hamster hybrid cell lines, that both the ZP3 and ZP3P loci are located on human chromosome 7.
van Duin
M
M
Department of Immunology, Organon International, Oss, The Netherlands.
Polman
J E
JE
Suikerbuijk
R F
RF
Geurts-van Kessel
A H
AH
Olijve
W
W
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D006224:Cricetinae; D004527:Egg Proteins; D006367:HeLa Cells; D006801:Humans; D006822:Hybrid Cells; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface; D015044:Zona Pellucida; D000072216:Zona Pellucida Glycoproteins
D004527:Egg Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C000606517:ZP3 protein, human; D000072216:Zona Pellucida Glycoproteins; C000606521:Zp3 protein, mouse