Mycobacterial infection in HIV+ patients detected with a new immunological method (TB test).
Antibody response to antigen A60 (a mycobacterial antigen) was evaluated in ELISA in 18 HIV+ subjects with clinical and cultural evidences of mycobacterial infections, in 10 HIV+ subjects without Mycobacterial infections and in 22 healthy donors. We found higher levels of specific IgG in the HIV+ patients with Mycobacterial infections (mean 179.2 +/- 83 U) compared to the values of the donors (mean 92.5 +/- 35.5 U: p < 0.01). This test may be useful in the diagnosis of tuberculosis, but it needs clinical validation.
Vanacore
R
R
Clinica Medica 1, Università di Pisa.
Paladini
A
A
Ceretelli
S
S
Savalli
E
E
Sbrana
S
S
Falsini
R
R
Scasso
A
A
Ambrogi
F
F
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008562:Membrane Glycoproteins / Q000276:immunology*; D009164:Mycobacterium Infections / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000302:isolation & purification*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000382:microbiology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; C055539:mycobacterial A60 antigen