title: Time course of dimension and function of the autologous pulmonary root in the aortic position.
abstract: Although the autologous, fully vital, and compatible pulmonary root theoretically offers the prospect of an ideal aortic valve substitute, this type of replacement is performed in only a few centers. Major concern relates to the fate of root dimension and function in the systemic circulation and is largely unknown. To investigate the fate of the aortic root, we conducted echocardiographic examinations of eight freestanding pulmonary roots used for aortic valve replacement in adults. The studies were performed at discharge from the hospital and up to 21 months (mean 12.5 +/- 6.6 months) after the operation, as well as in 26 matched control subjects. There were no significant differences between the first and second postoperative studies regarding the root diameter (mean 26.6 +/- 2.1 mm and 27.6 +/- 2.6 mm, respectively), which was within control limits, the maximum transvalvular pressure gradient (mean 4.6 +/- 1.2 mm Hg and 6.6 +/- 2.1 mm Hg, respectively), the maximum leaflet separation (mean 22.1 +/- 1.4 mm and 22.1 +/- 1.8 mm, respectively), and the degree of insufficiency. At the first study, grade I aortic regurgitation was found in four patients and grade I-II in one patient. Regurgitation increased slightly in one patient with an abnormal leaflet. In three patients primary grade I regurgitation disappeared. These data suggest that the pulmonary root in the aortic position can withstand systemic circulation without changes in dimension and function for up to 21 months. Furthermore, some evidence is provided to indicate that in certain cases the viable autograft may adapt to systemic pressure, as indicated by the disappearance of primary regurgitation.
authors: Department of Cardiovascular Surgery, University of Kiel, Germany.
authors: H H
authors: HH
authors: Sievers
authors: R
authors: R
authors: Leyh
authors: R
authors: R
authors: Loose
authors: M
authors: M
authors: Guha
authors: A
authors: A
authors: Petry
authors: A
authors: A
authors: Bernhard
mesh_terms: D001022:Aortic Valve Insufficiency / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D015150:Echocardiography, Doppler; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011664:Pulmonary Valve / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000637:transplantation*; D013997:Time Factors; D014182:Transplantation, Autologous