title: Dicyanogold (I) is a common human metabolite of different gold drugs.
abstract: Gold based drugs and their metabolites have been characterized using reversed phase, ion pairing chromatography with an inductively coupled plasma mass spectrometer as an element specific detector. For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood. The same compound is also identified in the urine and blood of a patient taking auranofin and in patients taking solganol. This represents the first identification of a specific gold metabolite in biological fluids taken from patients undergoing gold therapy and the first evidence that different gold drugs have common metabolites.
authors: Department of Chemistry, University of Cincinnati, OH 45221-0172.
authors: R C
authors: RC
authors: Elder
authors: Z
authors: Z
authors: Zhao
authors: Y
authors: Y
authors: Zhang
authors: J G
authors: JG
authors: Dorsey
authors: E V
authors: EV
authors: Hess
authors: K
authors: K
authors: Tepperman
mesh_terms: D000838:Anions; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D001310:Auranofin / Q000097:blood / Q000652:urine; D006051:Aurothioglucose / Q000097:blood / Q000652:urine; D003485:Cyanates / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006046:Gold / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006052:Gold Sodium Thiomalate / Q000097:blood / Q000652:urine; D006801:Humans
chemical_list: D000838:Anions; D003485:Cyanates; C043041:gold cyanide; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold