Effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema in the rat.
The effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema was studied in rats. The chloromethylketone human neutrophil elastase inhibitor, ICI 200,355, blunted rat leukocyte elastase activity in rat lung tissue. Administration of thrombin produced a significant increase (p < .01) in lung weight. The wet weight to dry weight ratio (WW/DW) and relative water contents were also significantly elevated (p < .01). Pretreatment with ICI 200,355 (200 micrograms/kg h-1) resulted in significant reductions (p < .05) in lung weight and a tendency to decrease WW/DW and water content compared with animals given thrombin alone. It is possible that the elastase inhibitor effectively reduced the rate of thrombin-induced pulmonary edema by attenuation of increased vascular permeability.
Ahn
C M
CM
Department of Internal Medicine, Yongsei University College of Medicine, Seoul Korea.
Sandler
H
H
Glass
M
M
Saldeen
T
T
D000595:Amino Acid Sequence; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000502:physiology*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000188:drug therapy*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D015843:Serpins; D013917:Thrombin
D009842:Oligopeptides; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C069366:ICI 200355; D010196:Pancreatic Elastase; D013917:Thrombin