Changes in auditory evoked responses during intravenous lidocaine.
Auditory evoked responses in 21 cases with tinnitus were recorded before and after the administration of intravenous lidocaine. A dosage of 1 mg/kg body weight was diluted with 20% glucose (20 ml) and administered intravenously over a one-min period. The loudness of tinnitus was evaluated during electrocochleography (ECochG) or auditory brain-stem response (ABR) recordings using a score between 0 and 11. The stimulus sound was a tone burst in a frequency that corresponded to the pitch of tinnitus. AP latency on ECochG and the inter peak latency (IPL) of wave I-III and wave III-V on ABR were prolonged momentarily and tinnitus was reduced. These findings reveal that the sites of action for lidocaine are both the inner ear and the brain-stem.
Ueda
S
S
Department of Otolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Aso
S
S
Watanabe
Y
Y
Mizukoshi
K
K
D001300:Audiometry, Evoked Response; D001933:Brain Stem / Q000187:drug effects; D003056:Cochlear Nerve / Q000187:drug effects; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000187:drug effects; D014012:Tinnitus / Q000188:drug therapy*
D008012:Lidocaine