Electrolytic stents to inhibit tumor growth. An experimental study in vitro and in rats.
Obstruction of metallic stents used in the management of malignant biliary strictures is common and in several cases due to tumor growth through the stent wall. In an experimental animal model in rats, a tumor was implanted subcutaneously adjacent to different metallic stents. Ingrowth of tumor through the wall of these stents was frequent. A stent generating direct electric current on the basis of electrolysis was developed and tested in vitro and in the experimental model. The study confirms that an "electrolytic" stent can inhibit ingrowth of tumor.
Cwikiel
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Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
Stridbeck
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Stenram
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U
D000818:Animals; D001650:Bile Duct Neoplasms / Q000517:prevention & control; D002455:Cell Division; D002779:Cholestasis / Q000628:therapy; D004572:Electrolysis; D004867:Equipment Design; D066298:In Vitro Techniques; D008670:Metals; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D011920:Rats, Inbred WF; D015607:Stents
D008670:Metals