Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter.
The neuronal Na(+)- and Cl(-)-dependent transporter for the neurotransmitter noradrenaline (NA) is the primary target for the tricyclic antidepressant desipramine. The NA-transporter belongs to a new gene family of structurally related Na(+)- and Cl(-)-dependent neurotransmitter transporters. In this study, the chromosomal localization for the gene encoding the human NA-transporter (h-NAT) was determined. By hybridization of a panel of somatic cell hybrids and by fluorescent in situ hybridization to metaphase chromosomes, the hNAT gene was localized on chromosome 16q12.2. In addition, evidence is presented for an intron-exon structure of the gene.
Brüss
M
M
Institut für Pharmakologie und Toxikologie, Universität Bonn, Germany.
Kunz
J
J
Lingen
B
B
Bönisch
H
H
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D002352:Carrier Proteins / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D009638:Norepinephrine / Q000378:metabolism*; D050484:Norepinephrine Plasma Membrane Transport Proteins; D012377:Rodentia; D027981:Symporters; D014407:Tumor Cells, Cultured
D000929:Antidepressive Agents, Tricyclic; D002352:Carrier Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters; D009638:Norepinephrine