Selenium lethality: role of glutathione and metallothionein.
Male Sprague-Dawley rats (200-300 g) were pretreated (i.p.) with diethylmaleate (DEM; 3.1 mmol/kg) or propylene glycol (PG). After 1 h, three PG and three DEM groups received saline or sodium selenite (Se: 0.8 or 1.6 mg/kg) i.p. Eighty to one hundred percent mortality occurred within 3 h after Se in DEM-pretreated groups. Except for one PG and one DEM group, which were sacrificed after 1 h, the remaining groups received saline or Se (1.6 mg/kg) 25 h after pretreatment. No mortality occurred within 3 h after Se. Liver and kidney GSH decreased at 1 h, while liver MT increased at 28 h. The changes are related to Se-induced lethality.
Nonavinakere
V K
VK
Florida A&M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, FL 32307.
Potmis
R A
RA
Rasekh
H R
HR
Bell
R R
RR
Early
J L
JL
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008668:Metallothionein / Q000378:metabolism*; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000633:toxicity*
D008298:Maleates; D011409:Propylene Glycols; D019946:Propylene Glycol; D008668:Metallothionein; C014476:diethyl maleate; D005978:Glutathione; D012643:Selenium