[Prophylactic inhalation of amphotericin B in invasive aspergillosis: a distribution study].
Invasive pulmonary aspergillosis (IPA) during periods of immunosuppression or prolonged neutropenia is a serious condition with high mortality. Prophylaxis is unsatisfactory because of the low effectiveness of systemic administration of amphotericin B (AMB) and because of its side effects. Prophylactic inhalation of AMB by means of a nebulizing system may be able to reduce the incidence of IPA. Therefore, we studied the distribution of nebulized 99mTc-labeled AMB and estimated its particle size. AMB is homogeneously distributed in the lung and partly deposited in the terminal respiratory unit; it remains there with a half-life of at least 14 h. Therefore, prophylaxis of IPA with AMB nebulized as described can be recommended.
Barzen
G
G
Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow, FRG.
Beyer
J
J
Farshidfar
G
G
Kramp
W
W
Richter
W
W
Felix
R
R
D000280:Administration, Inhalation; D000666:Amphotericin B / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001228:Aspergillosis / Q000517:prevention & control*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000517:prevention & control*; D010316:Particle Size; D014018:Tissue Distribution
D000666:Amphotericin B
Prophylaktische Inhalation von Amphotericin B bei invasiver Aspergillose: Verteilungsstudie.