Comparison of surface fibroblastic cells in subcutaneous air pouch and synovial lining: differences in uridine diphosphoglucose dehydrogenase activity.
In contrast to synovial tissue, rat subcutaneous air pouch lining was found to lack cells showing high activity of uridine diphosphoglucose dehydrogenase, an enzyme involved in hyaluronan synthesis. This indicates that the properties of cells on the surface of synovium are not determined simply by tissue cavitation. Shearing forces may be more important in inducing the specialized behaviour of synovial surface fibroblasts.
Wilkinson
L S
LS
Department of Rheumatology Research, University College and Middlesex School of Medicine, London, UK.
Moore
A R
AR
Pitsillides
A A
AA
Willoughby
D A
DA
Edwards
J C
JC
D000388:Air; D000818:Animals; D003238:Connective Tissue / Q000201:enzymology; D005347:Fibroblasts / Q000201:enzymology; D008954:Models, Biological; D051381:Rats; D013583:Synovial Membrane / Q000201:enzymology*; D014533:Uridine Diphosphate Glucose Dehydrogenase / Q000378:metabolism*
D014533:Uridine Diphosphate Glucose Dehydrogenase