A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue.
The gene encoding a cysteine proteinase of the murine malaria parasite Plasmodium vinckei has been identified and characterized. The gene encodes a papain-family proteinase that shares unique features with a previously described P. falciparum cysteine proteinase. We hypothesize that both enzymes mediate the hydrolysis of hemoglobin, and perhaps other Plasmodium-specific functions.
Rosenthal
P J
PJ
Department of Medicine, San Francisco General Hospital, University of California 94143.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003546:Cysteine Endopeptidases / Q000235:genetics* / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D008969:Molecular Sequence Data; D010961:Plasmodium / Q000201:enzymology*; D010963:Plasmodium falciparum / Q000201:enzymology*; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment
D006454:Hemoglobins; D003546:Cysteine Endopeptidases