Aminoglutethimide (AG) and hydrocortisone (HC) in bone metastases: a retrospective study.
The response rate in bone metastases in 57 patients treated with aminoglutethimide and hydrocortisone was retrospectively assessed. All the X-rays were reviewed by two senior radiologists. A response was observed in 23% of the patients, a stabilization in 32%. The survival was not different whether a response or stabilization was observed. Conversely, survival was significantly worse in patients who experienced a progressive disease.
Bonneterre
J
J
Centre Oscar Lambret, Lille, France.
Adenis
A
A
Pion
J M
JM
Cambier
L
L
Kamus
E
E
Hecquet
B
B
D000328:Adult; D000368:Aged; D000616:Aminoglutethimide / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology / Q000556:secondary*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D011859:Radiography; D012189:Retrospective Studies; D013997:Time Factors
D000616:Aminoglutethimide; D006854:Hydrocortisone